LiteFold/InterPro · Datasets at Hugging Face

IPR018583

18,583

Cotton leaf-curl disease, DNA-betaC1

CLCuD_DNA-betaC1

Domain

1,110

false

Cotton leaf-curl disease - CLCuD - is of major economic importance in cotton-growing areas of the far-east. The infectious agent appears to be a single-stranded DNA molecule of approx 1350 nucleotides in length, which, when inoculated with the Begomovirus into cotton, induces symptoms typical of CLCuD. This molecule re...

[]

0

[ "PFAM" ]

[ "PF09593" ]

[ "Pathogen_betaC1" ]

[ 1110 ]

1

[]

0

[]

0

[ "PUB00044423", "PUB00044424" ]

[ "11437658", "17872543" ]

[ "Identification of dna components required for induction of cotton leaf curl disease.", "A monopartite begomovirus-associated DNA beta satellite substitutes for the DNA B of a bipartite begomovirus to permit systemic infection." ]

[ 2001, 2007 ]

2

[]

0

null

[ "Viruses" ]

[ 1110 ]

1

[]

0

true

Domain

Cotton leaf-curl disease, DNA-betaC1

CLCuD_DNA-betaC1

3

IPR018584

18,584

Glycosyltransferase family 87

GT87

Family

19,763

false

The enzymes in this family are glycosyltransferases. PimE is involved in phosphatidylinositol mannoside (PIM) synthesis, a major class of glycolipids in all mycobacteria. PimE is a polyprenol-phosphate-mannose-dependent mannosyltransferase that transfers the fifth mannose of PIM [ ]. The family also includes alpha(1-->...

[ "GO:0016758" ]

[ "hexosyltransferase activity" ]

[ "molecular_function" ]

1

[ "PFAM" ]

[ "PF09594" ]

[ "GT87" ]

[ 19763 ]

1

[ "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC"...

[ "2.4.1.-", "PWY-1901", "PWY-1961", "PWY-1981", "PWY-2021", "PWY-2881", "PWY-2901", "PWY-2902", "PWY-4421", "PWY-4801", "PWY-5094", "PWY-5105", "PWY-5129", "PWY-5139", "PWY-5160", "PWY-5161", "PWY-5268", "PWY-5284", "PWY-5286", "PWY-5310", "PWY-5312", "PWY-5313", "PWY-5317...

[ "EC:2.4.1.-", "METACYC:PWY-1901", "METACYC:PWY-1961", "METACYC:PWY-1981", "METACYC:PWY-2021", "METACYC:PWY-2881", "METACYC:PWY-2901", "METACYC:PWY-2902", "METACYC:PWY-4421", "METACYC:PWY-4801", "METACYC:PWY-5094", "METACYC:PWY-5105", "METACYC:PWY-5129", "METACYC:PWY-5139", "METACYC:PWY-5...

200

[ "9dm5", "9dm7", "9mjb" ]

3

[ "PUB00075385", "PUB00075386" ]

[ "16803893", "18627460" ]

[ "PimE is a polyprenol-phosphate-mannose-dependent mannosyltransferase that transfers the fifth mannose of phosphatidylinositol mannoside in mycobacteria.", "Biosynthesis of mycobacterial arabinogalactan: identification of a novel alpha(1-->3) arabinofuranosyltransferase." ]

[ 2006, 2008 ]

2

[]

[ "IPR016570" ]

0

1

0

[ "Archaea", "Bacteria", "Eukaryota", "Methanophagales virus PBV082", "unclassified sequences" ]

[ 176, 19411, 10, 1, 165 ]

5

[]

0

true

Family

Glycosyltransferase family 87

GT87

9

IPR018585

18,585

Metaviral G glycoprotein

Metaviral_G_glycop

Domain

2,011

false

This is a viral attachment glycoprotein from region G of metaviruses. It is high in serine and threonine suggesting it is highly glycosylated [ ].

[]

0

[ "PFAM" ]

[ "PF09595" ]

[ "Metaviral_G" ]

[ 2011 ]

1

[]

0

[]

0

[ "PUB00044359" ]

[ "16555281" ]

[ "Genetic heterogeneity of G and F protein genes from Argentinean human metapneumovirus strains." ]

[ 2006 ]

1

[]

0

null

[ "Metapneumovirus hominis" ]

[ 2011 ]

1

[]

0

true

Domain

Metaviral G glycoprotein

Metaviral_G_glycop

6

IPR018587

18,587

White spot syndrome virus (WSSV), Orf116/126, N-terminal

WSSV_Orf116/126_N

Domain

43

false

VP9 is a protein containing a ferredoxin fold. Two dimers come together to form one asymmetric unit which possesses a DNA recognition fold and specific metal binding sites possibly for zinc. It is postulated that being a non-structural protein VP9 is involved in the transcriptional regulation of the White spot syndrome...

[]

0

[ "PFAM" ]

[ "PF09625" ]

[ "VP9" ]

[ 43 ]

1

[]

0

[ "2gj2", "2gji", "2zug" ]

3

[ "PUB00041073", "PUB00050445" ]

[ "16956937", "19095797" ]

[ "Identification of a novel nonstructural protein, VP9, from white spot syndrome virus: its structure reveals a ferredoxin fold with specific metal binding sites.", "White spot syndrome virus protein ICP11: A histone-binding DNA mimic that disrupts nucleosome assembly." ]

[ 2006, 2008 ]

2

[]

0

null

[ "White spot syndrome virus" ]

[ 43 ]

1

[]

0

true

Domain

White spot syndrome virus (WSSV), Orf116/126, N-terminal

WSSV_Orf116/126_N

9

IPR018588

18,588

Dihaem cytochrome c

Dihaem_cytochrome-c

Family

1,375

false

Dihaem cytochrome c (DHC) is a soluble c-type cytochrome that folds into two distinct domains, each binding a single haem group and connected by a small linker region. Despite little sequence similarity, the N-terminal domain (residues 12-75) is a class I type cytochrome c, that binds one of the haems, but the domain s...

[]

0

[ "PFAM" ]

[ "PF09626" ]

[ "DHC" ]

[ 1375 ]

1

[]

0

[ "2fw5", "2fwt", "3u99" ]

3

[ "PUB00040838" ]

[ "16700547" ]

[ "Structural and functional studies on DHC, the diheme cytochrome c from Rhodobacter sphaeroides, and its interaction with SHP, the sphaeroides heme protein." ]

[ 2006 ]

1

[]

0

null

[ "Bacteria", "Opisthokonta", "metagenomes" ]

[ 1331, 2, 42 ]

3

[]

0

true

Family

Dihaem cytochrome c

Dihaem_cytochrome-c

6

IPR018589

18,589

Pheromone response, PrgU-like domain

Pheromone_resp_PrgU-like

Domain

37

false

PrgU is a protein of plasmid in origin expressed mainly in Enterococcus bacteria. It forms a six β-strand barrel with three accompanying α helices and is probably a homo-dimer in the cell [ ]. PrgU probably acts as a RNA-binding regulator that mitigates toxicity accompanying overproduction of PrgB-like adhesins, which ...

[]

0

[ "PFAM" ]

[ "PF09627" ]

[ "PrgU" ]

[ 37 ]

1

[]

0

[ "2gmq" ]

1

[ "PUB00044448", "PUB00088212" ]

[ "17302827", "27785854" ]

[ "Specificity determinants of conjugative DNA processing in the Enterococcus faecalis plasmid pCF10 and the Lactococcus lactis plasmid pRS01.", "PrgU: a suppressor of sex pheromone toxicity in Enterococcus faecalis." ]

[ 2007, 2017 ]

2

[]

0

null

[ "Lactobacillales", "human gut metagenome" ]

[ 35, 2 ]

2

[]

0

true

Domain

Pheromone response, PrgU-like domain

Pheromone_resp_PrgU-like

6

IPR018590

18,590

Uncharacterised protein YvfG

Uncharacterised_YvfG

Family

121

false

Yvfg is a hypothetical protein of 71 residues expressed in some bacteria. The monomer consists of two parallel α-helices, and the protein crystallises as a homodimer.

[]

0

[ "PFAM" ]

[ "PF09628" ]

[ "YvfG" ]

[ 121 ]

1

[]

0

[ "2gsv", "2js1" ]

2

[]

0

[]

0

null

[ "Bacillales" ]

[ 121 ]

1

[]

0

true

Family

Uncharacterised protein YvfG

Uncharacterised_YvfG

7

IPR018591

18,591

YorP protein

YorP

Family

26

false

YorP is a 71 residue protein found in bacteria. As it is also found in a bacteriophage it might be of viral origin. The structure is of an α helix between two of five β strands. The function is unknown.

[]

0

[ "PFAM" ]

[ "PF09629" ]

[ "YorP" ]

[ 26 ]

1

[]

0

[ "2heq" ]

1

[]

0

[]

0

null

[ "Bacillaceae", "Bacillus phage SPbeta" ]

[ 25, 1 ]

2

[]

0

true

Family

YorP protein

YorP

4

IPR018592

18,592

Protein of unknown function DUF2024

DUF2024

Family

557

false

This protein of 86 residues is expressed in bacteria. It consists of two α helices and four β strands. Its function is unknown.

[]

0

[ "PFAM" ]

[ "PF09630" ]

[ "DUF2024" ]

[ 557 ]

1

[]

0

[ "2hfq" ]

1

[]

0

[]

0

null

[ "Nitrososphaerota", "Pseudomonadati", "ecological metagenomes" ]

[ 84, 462, 11 ]

3

[]

0

true

Family

Protein of unknown function DUF2024

DUF2024

9

IPR018593

18,593

tRNA-splicing endonuclease subunit Sen15

tRNA-endonuc_su_Sen15

Domain

2,989

false

The Sen15 subunit of the tRNA intron-splicing endonuclease is one of the two structural subunits of this heterotetrameric enzyme. Residues 36-157 of this subunit possess a novel homodimeric fold. Each monomer consists of three α-helices and a mixed antiparallel/parallel β-sheet. Two monomers of Sen15 fold with two mono...

[]

0

[ "PFAM" ]

[ "PF09631" ]

[ "Sen15" ]

[ 2989 ]

1

[ "REACTOME" ]

[ "R-HSA-6784531" ]

[ "REACTOME:R-HSA-6784531" ]

1

[ "2gw6", "6z9u", "7uxa", "7zrz", "8hmy", "8hmz", "8iss" ]

7

[ "PUB00045130" ]

[ "17166513" ]

[ "Three-dimensional structure determined for a subunit of human tRNA splicing endonuclease (Sen15) reveals a novel dimeric fold." ]

[ 2007 ]

1

[]

0

null

[ "Eukaryota", "Pyrobaculum calidifontis (strain DSM 21063 / JCM 11548 / VA1)" ]

[ 2988, 1 ]

2

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 2, 1, 13, 3, 1, 4, 1, 1 ]

8

true

Domain

tRNA-splicing endonuclease subunit Sen15

tRNA-endonuc_su_Sen15

4

IPR018597

18,597

Bacteriophage Tuc2009, YjcQ

Phage_Tuc2009_YjcQ

Family

368

false

YjcQ is a protein of approx. 100 residues containing four α helices and three β strands. It is found in bacteria and also in the Lactococcus phage Tuc2009. In bacteria it appears to be under the regulation of SigD RNA polymerase which is responsible for the expression of many genes encoding cell-surface proteins relate...

[]

0

[ "PFAM" ]

[ "PF09639" ]

[ "YjcQ" ]

[ 368 ]

1

[]

0

[ "2hgc" ]

1

[ "PUB00044231", "PUB00044550" ]

[ "15016546", "15033535" ]

[ "The prophages of Lactobacillus johnsonii NCC 533: comparative genomics and transcription analysis.", "Systematic analysis of SigD-regulated genes in Bacillus subtilis by DNA microarray and Northern blotting analyses." ]

[ 2004, 2004 ]

2

[]

0

null

[ "Bacteria", "Viruses", "bioreactor metagenome" ]

[ 336, 29, 3 ]

3

[]

0

true

Family

Bacteriophage Tuc2009, YjcQ

Phage_Tuc2009_YjcQ

6

IPR018598

18,598

Domain of unknown function DUF2027

DUF2027

Domain

755

false

Proteins with this domain are uncharacterised, but may be involved in DNA mismatch repair. The domain is similar to the Smr domain ( ).

[]

0

[ "PFAM" ]

[ "PF09640" ]

[ "DUF2027" ]

[ 755 ]

1

[]

0

[ "2huh" ]

1

[]

0

[]

0

null

[ "Bacteria", "metagenomes" ]

[ 725, 30 ]

2

[]

0

true

Domain

Domain of unknown function DUF2027

DUF2027

4

IPR018599

18,599

Protein of unknown function DUF2026

DUF2026

Family

185

false

This protein of approx. 100 residues is found in bacteria. It contains up to five α helices and up to seven β strands and is probably monomeric. Its function is unknown.

[]

0

[ "PFAM" ]

[ "PF09641" ]

[ "DUF2026" ]

[ 185 ]

1

[]

0

[ "2hly" ]

1

[]

0

[]

0

null

[ "Bacteria", "unclassified sequences" ]

[ 182, 3 ]

2

[]

0

true

Family

Protein of unknown function DUF2026

DUF2026

4

IPR018600

18,600

Bacillus phage SPbeta, YonK

Phage_SP-beta_YonK

Domain

104

false

YonK protein is expressed by the bacterial prophage SPbetaC [ ]. It is a 63 residue protein that associates into a homo-octamer in the form of a β-stranded barrel with four outer helical features at points of the compass. Its function is unknown.

[]

0

[ "PFAM" ]

[ "PF09642" ]

[ "YonK" ]

[ 104 ]

1

[]

0

[ "2h4o" ]

1

[ "PUB00044553" ]

[ "10376821" ]

[ "Nucleotide sequence of the Bacillus subtilis temperate bacteriophage SPbetac2." ]

[ 1999 ]

1

[]

0

null

[ "Bacillota", "Viruses" ]

[ 80, 24 ]

2

[]

0

true

Domain

Bacillus phage SPbeta, YonK

Phage_SP-beta_YonK

9

IPR018601

18,601

Sulfolobus spindle-shape virus 1 F-112 protein-like

SSV1_F112-like

Family

8

false

This entry is represented by Sulfolobus spindle-shape virus 1 (SSV1), F112 protein [ , ]. This protein adopts a winged helix DNA binding fold containing an intrachain disulfide bond [ ]. The characteristics of the protein distribution suggest prophage matches in addition to the phage matches.

[]

0

[ "PFAM" ]

[ "PF09645" ]

[ "F-112" ]

[ 8 ]

1

[]

0

[ "2vqc" ]

1

[ "PUB00046115", "PUB00049853" ]

[ "10430570", "18471851" ]

[ "Genetic requirements for the function of the archaeal virus SSV1 in Sulfolobus solfataricus: construction and testing of viral shuttle vectors.", "Cysteine usage in Sulfolobus spindle-shaped virus 1 and extension to hyperthermophilic viruses in general." ]

[ 1999, 2008 ]

2

[]

0

null

[ "Sulfolobaceae", "Viruses incertae sedis" ]

[ 5, 3 ]

2

[]

0

true

Family

Sulfolobus spindle-shape virus 1 F-112 protein-like

SSV1_F112-like

1

IPR018602

18,602

Gp37/putative cytoplasmic protein STM4215

Gp37/STM4215

Family

684

false

This protein consists of a unit of helices and β-sheets that crystallises into a beautiful asymmetrical dodecameric barrel-structure, of two six-membered rings one on top of the other. It is expressed in bacteria but is of viral origin, as it is found in phage BcepMu and is probably a pathogenesis factor [ ]. This entr...

[]

0

[ "PFAM" ]

[ "PF09646" ]

[ "Gp37" ]

[ 684 ]

1

[]

0

[ "2gjv" ]

1

[ "PUB00044286" ]

[ "15184022" ]

[ "Burkholderia cenocepacia phage BcepMu and a family of Mu-like phages encoding potential pathogenesis factors." ]

[ 2004 ]

1

[]

0

null

[ "Bacteria", "Caudoviricetes", "Glossina brevipalpis" ]

[ 668, 15, 1 ]

3

[]

0

true

Family

Gp37/putative cytoplasmic protein STM4215

Gp37/STM4215

5

IPR018604

18,604

Regulatory protein YycH-like

YycI-like

Domain

2,816

false

The YycFG two-component system is the only signal transduction system in Bacillus subtilis known to be essential for cell viability. This system is highly conserved in low-G+C Gram-positive bacteria, regulating important processes such as cell wall homeostasis, cell membrane integrity, and cell division. Four other gen...

[ "GO:0016020" ]

[ "membrane" ]

[ "cellular_component" ]

1

[ "PFAM" ]

[ "PF09648" ]

[ "YycI" ]

[ 2816 ]

1

[]

0

[ "2o3o" ]

1

[ "PUB00042101", "PUB00045177" ]

[ "17307848", "17307850" ]

[ "The crystal structure of Bacillus subtilis YycI reveals a common fold for two members of an unusual class of sensor histidine kinase regulatory proteins.", "YycH and YycI interact to regulate the essential YycFG two-component system in Bacillus subtilis." ]

[ 2007, 2007 ]

2

[]

0

null

[ "Bacteria", "Methanofollis liminatans", "Trichuris trichiura", "bioreactor metagenome" ]

[ 2809, 2, 1, 4 ]

4

[]

0

true

Domain

Regulatory protein YycH-like

YycI-like

5

IPR018605

18,605

Sororin protein

Sororin

Family

559

false

Sororin is an essential, cell cycle-dependent mediator of sister chromatid cohesion [ ]. The protein is nuclear in interphase cells, dispersed from the chromatin in mitosis, and interacts with the cohesin complex [ ]. This protein protects cohesin from WAPL, which otherwise releases cohesin from DNA [ ]. Also included ...

[]

0

[ "PANTHER" ]

[ "PTHR31092" ]

[ "" ]

[ 559 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-2467813", "R-HSA-2468052", "R-HSA-2500257", "R-MMU-2467813", "R-MMU-2468052", "R-MMU-2500257" ]

[ "REACTOME:R-HSA-2467813", "REACTOME:R-HSA-2468052", "REACTOME:R-HSA-2500257", "REACTOME:R-MMU-2467813", "REACTOME:R-MMU-2468052", "REACTOME:R-MMU-2500257" ]

6

[]

0

[ "PUB00044494", "PUB00158890" ]

[ "15837422", "38830897" ]

[ "Sororin, a substrate of the anaphase-promoting complex, is required for sister chromatid cohesion in vertebrates.", "Sororin is an evolutionary conserved antagonist of WAPL." ]

[ 2005, 2024 ]

2

[]

0

null

[ "Chordata" ]

[ 559 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 3, 1, 5 ]

4

true

Family

Sororin protein

Sororin

7

IPR018607

18,607

Chromosome transmission fidelity protein 8

Ctf8

Family

3,428

false

Ctf8 is a component of the RFC-like complex CTF18-RFC which is required for efficient establishment of chromosome cohesion during S-phase and may load or unload POL30/PCNA. During a clamp loading circle, the RFC:clamp complex binds to DNA and the recognition of the double-stranded/single-stranded junction stimulates AT...

[ "GO:0007064", "GO:0031390" ]

[ "mitotic sister chromatid cohesion", "Ctf18 RFC-like complex" ]

[ "biological_process", "cellular_component" ]

2

[ "PFAM" ]

[ "PF09696" ]

[ "Ctf8" ]

[ 3428 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-174411", "R-HSA-174411", "R-MMU-174411", "R-RNO-174411" ]

[ "REACTOME:R-BTA-174411", "REACTOME:R-HSA-174411", "REACTOME:R-MMU-174411", "REACTOME:R-RNO-174411" ]

4

[ "5msm", "5okc", "5oki", "6s1c", "6s2e", "6s2f", "8tw9", "8twa" ]

8

[ "PUB00045276", "PUB00045277" ]

[ "11389843", "15964801" ]

[ "Identification of RFC(Ctf18p, Ctf8p, Dcc1p): an alternative RFC complex required for sister chromatid cohesion in S. cerevisiae.", "Replication protein A-directed unloading of PCNA by the Ctf18 cohesion establishment complex." ]

[ 2001, 2005 ]

2

[]

0

null

[ "Eukaryota", "bird metagenome" ]

[ 3427, 1 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 6, 1, 1, 4, 2, 2, 1, 2, 1, 1, 1, 4 ]

12

true

Family

Chromosome transmission fidelity protein 8

Ctf8

6

IPR018608

18,608

Global transcription regulator

Gti1/Pac2

Family

5,431

false

This entry represents global transcription factors found in fungi. In Schizosaccharomyces pombe the Gti1 protein promotes the onset of gluconate uptake upon glucose starvation [ ]. The Pac2 protein controls the onset of sexual development by inhibiting the expression of ste11 in a pathway that is independent of the cAM...

[]

0

[ "PFAM", "PANTHER" ]

[ "PF09729", "PTHR28027" ]

[ "Gti1_Pac2", "" ]

[ 5396, 5297 ]

2

[]

0

[ "4m8b", "4qtj", "4qtk" ]

3

[ "PUB00044289", "PUB00044290", "PUB00163265" ]

[ "9372449", "8536311", "19851506" ]

[ "Onset of gluconate-H+ symport in Schizosaccharomyces pombe is regulated by the kinases Wis1 and Pka1, and requires the gti1+ gene product.", "Schizosaccharomyces pombe pac2+ controls the onset of sexual development via a pathway independent of the cAMP cascade.", "The nuclear protein Sge1 of Fusarium oxysporum...

[ 1997, 1995, 2009 ]

3

[]

0

null

[ "Eukaryota" ]

[ 5431 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 2, 2 ]

3

true

Family

Global transcription regulator

Gti1/Pac2

3

IPR018609

18,609

Bud13

Family

4,488

false

Bud site selection protein 13, also known as pre-mRNA-splicing factor CWC26, belongs to the pre-mRNA retention and splicing (RES) complex. May also be involved in positioning the proximal bud pole signal [ , , ]. The presence of RES subunit homologues in numerous eukaryotes suggests that its function is evolutionarily ...

[]

0

[ "PFAM" ]

[ "PF09736" ]

[ "Bud13" ]

[ 4488 ]

1

[ "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-72163", "R-MMU-72163", "R-RNO-72163" ]

[ "REACTOME:R-HSA-72163", "REACTOME:R-MMU-72163", "REACTOME:R-RNO-72163" ]

3

[ "2mkc", "2my2", "4uqt", "5gm6", "5lqw", "5z56", "5z57", "5z58", "5zwm", "5zwo", "6ff4", "6ff7", "7abi", "7dco", "7dvq", "7qtt", "8ch6", "8i0p", "8i0r" ]

19

[ "PUB00035364", "PUB00042559", "PUB00053889", "PUB00053890" ]

[ "11452010", "15565172", "8657162", "12871902" ]

[ "A genomic study of the bipolar bud site selection pattern in Saccharomyces cerevisiae.", "Proteomic analysis identifies a new complex required for nuclear pre-mRNA retention and splicing.", "Genetic analysis of the bipolar pattern of bud site selection in the yeast Saccharomyces cerevisiae.", "Genetic intera...

[ 2001, 2004, 1996, 2003 ]

4

[]

0

null

[ "Eukaryota" ]

[ 4488 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 5, 1, 1, 1, 2, 2, 1, 5, 4, 1, 1, 5 ]

12

true

Family

Bud13

3

IPR018610

18,610

UV-stimulated scaffold protein A

UVSSA

Family

2,483

false

UV-stimulated scaffold protein A (UVSSA) is part of a UV-induced ubiquitinated protein complex involved in transcription-coupled nucleotide excision repair (TC-NER) in response to UV damage. It stabilise the TC-NER master organising protein ERCC6 (also known as CSB) by delivering the deubiquitinating enzyme USP7 to TC-...

[ "GO:0009411" ]

[ "response to UV" ]

[ "biological_process" ]

1

[ "PANTHER" ]

[ "PTHR28670" ]

[ "" ]

[ 2483 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-CEL-6781823", "R-CEL-6782135", "R-CEL-6782210", "R-DRE-6781823", "R-DRE-6782135", "R-HSA-6781823", "R-HSA-6781827", "R-HSA-6782135", "R-HSA-6782210", "R-MMU-6781823", "R-MMU-6782135", "R-MMU-6782210", "R-RNO-6781823", "R-RNO-6782135", "R-RNO-6782210", "R-XTR-6781823", "R-XTR-67821...

[ "REACTOME:R-CEL-6781823", "REACTOME:R-CEL-6782135", "REACTOME:R-CEL-6782210", "REACTOME:R-DRE-6781823", "REACTOME:R-DRE-6782135", "REACTOME:R-HSA-6781823", "REACTOME:R-HSA-6781827", "REACTOME:R-HSA-6782135", "REACTOME:R-HSA-6782210", "REACTOME:R-MMU-6781823", "REACTOME:R-MMU-6782135", "REACTOM...

18

[ "7oo3", "7oop", "7opc", "7opd", "8b3d", "8b3g", "8qh5", "9bz0", "9er2", "9fd2", "9hwg" ]

11

[ "PUB00090439", "PUB00152779", "PUB00152780", "PUB00152782" ]

[ "22466611", "22466610", "22466612", "32142649" ]

[ "UV-sensitive syndrome protein UVSSA recruits USP7 to regulate transcription-coupled repair.", "Mutations in UVSSA cause UV-sensitive syndrome and impair RNA polymerase IIo processing in transcription-coupled nucleotide-excision repair.", "Mutations in UVSSA cause UV-sensitive syndrome and destabilize ERCC6 in ...

[ 2012, 2012, 2012, 2020 ]

4

[]

0

null

[ "Eukaryota" ]

[ 2483 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 4, 1, 1, 6, 2, 5, 3, 8 ]

8

true

Family

UV-stimulated scaffold protein A

UVSSA

9

IPR018611

18,611

E3 UFM1-protein ligase 1

Ufl1

Family

3,368

false

This entry represents E3 UFM1-protein ligase 1 (Ufl1). The ubiquitin fold modifier 1 (Ufm1) is the most recently discovered ubiquitin-like modifier whose conjugation (ufmylation) system is conserved in multicellular organisms. Ufm1 is known to covalently attach with cellular protein(s) via a specific E1-activating enzy...

[ "GO:0061666", "GO:0071569" ]

[ "UFM1 ligase activity", "protein ufmylation" ]

[ "molecular_function", "biological_process" ]

2

[ "PANTHER" ]

[ "PTHR31057" ]

[ "" ]

[ 3368 ]

1

[ "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "2.3.2.-", "PWY-6289", "PWY-6462", "PWY-6463", "PWY-6682", "PWY-6841", "PWY-7815", "PWY-7816", "PWY-7817", "PWY-7818", "PWY-7887", "R-BTA-983168", "R-CEL-983168", "R-DDI-983168", "R-DME-983168", "R-DRE-983168", "R-HSA-983168", "R-MMU-983168", "R-RNO-983168" ]

[ "EC:2.3.2.-", "METACYC:PWY-6289", "METACYC:PWY-6462", "METACYC:PWY-6463", "METACYC:PWY-6682", "METACYC:PWY-6841", "METACYC:PWY-7815", "METACYC:PWY-7816", "METACYC:PWY-7817", "METACYC:PWY-7818", "METACYC:PWY-7887", "REACTOME:R-BTA-983168", "REACTOME:R-CEL-983168", "REACTOME:R-DDI-983168", ...

19

[ "8b9x", "8c0d", "8ohd", "8oj0", "8oj5", "8oj8", "8qfc", "8qfd", "9gy4" ]

9

[ "PUB00054168", "PUB00086011", "PUB00088961", "PUB00095670", "PUB00095671", "PUB00159944" ]

[ "20018847", "20228063", "25219498", "32160526", "20164180", "38383789" ]

[ "A novel type of E3 ligase for the Ufm1 conjugation system.", "A novel C53/LZAP-interacting protein regulates stability of C53/LZAP and DDRGK domain-containing Protein 1 (DDRGK1) and modulates NF-kappaB signaling.", "Modification of ASC1 by UFM1 is crucial for ERα transactivation and breast cancer development."...

[ 2010, 2010, 2014, 2020, 2010, 2024 ]

6

[]

0

null

[ "Eukaryota" ]

[ 3368 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 8, 1, 1, 2, 2, 1, 1, 3, 9 ]

9

true

Family

E3 UFM1-protein ligase 1

Ufl1

6

IPR018612

18,612

Nuclear speckle splicing regulatory protein 1, N-terminal

NSRP1_N

Domain

4,350

false

This domain is found at the N-terminal of Nuclear speckle splicing regulatory protein 1 (NRP1, also known as Nuclear speckle-related protein 70 and Coiled-coil domain-containing protein 55) and contains a coiled-coil domain that plays a critical role in NRP1 alternative splicing activity and self-oligomerization. NRP1 ...

[ "GO:0000381" ]

[ "regulation of alternative mRNA splicing, via spliceosome" ]

[ "biological_process" ]

1

[ "PFAM" ]

[ "PF09745" ]

[ "NSRP1_N" ]

[ 4350 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-72163", "R-CEL-72163", "R-DRE-72163", "R-HSA-72163", "R-MMU-72163", "R-RNO-72163" ]

[ "REACTOME:R-BTA-72163", "REACTOME:R-CEL-72163", "REACTOME:R-DRE-72163", "REACTOME:R-HSA-72163", "REACTOME:R-MMU-72163", "REACTOME:R-RNO-72163" ]

6

[]

0

[ "PUB00093375", "PUB00093376" ]

[ "26797131", "21296756" ]

[ "Nuclear Speckle-related Protein 70 Binds to Serine/Arginine-rich Splicing Factors 1 and 2 via an Arginine/Serine-like Region and Counteracts Their Alternative Splicing Activity.", "NSrp70 is a novel nuclear speckle-related protein that modulates alternative pre-mRNA splicing in vivo." ]

[ 2016, 2011 ]

2

[]

0

null

[ "Eukaryota" ]

[ 4350 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Schizosaccharomyces pombe (stra...

[ 12, 1, 2, 3, 10, 6, 1, 4, 5, 1, 3 ]

11

true

Domain

Nuclear speckle splicing regulatory protein 1, N-terminal

NSRP1_N

7

IPR018613

18,613

Ccdc97-like

Family

3,187

false

This family includes coiled-coil domain-containing proteins of unknown function.

[]

0

[ "PANTHER" ]

[ "PTHR31840" ]

[ "" ]

[ 3187 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Eukaryota", "bird metagenome" ]

[ 3186, 1 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 5, 3, 1, 1, 2, 2, 1, 5, 2, 3 ]

10

true

Family

Ccdc97-like

6

IPR018614

18,614

Keratinocyte-associated protein 2

KRTCAP2

Family

2,017

false

Members of this family comprise various keratinocyte-associated proteins, including human Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit KCP2 (also known as Keratinocyte-associated protein 2), a subunit of the oligosaccharyl transferase complex that catalyses the initial in protein N-glycosylati...

[]

0

[ "PFAM", "PANTHER" ]

[ "PF09775", "PTHR32001" ]

[ "Keratin_assoc", "" ]

[ 2015, 1947 ]

2

[]

0

[]

0

[ "PUB00155431" ]

[ "22467853" ]

[ "The oligosaccharyltransferase subunits OST48, DAD1 and KCP2 function as ubiquitous and selective modulators of mammalian N-glycosylation." ]

[ 2012 ]

1

[]

0

null

[ "Eukaryota" ]

[ 2017 ]

1

[ "Arabidopsis thaliana", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 2, 1, 2, 5, 2, 4, 6, 4 ]

8

true

Family

Keratinocyte-associated protein 2

KRTCAP2

8

IPR018615

18,615

Large ribosomal subunit protein mL55

Ribosomal_mL55

Family

1,358

false

This entry represents the large ribosomal subunit protein mL55 from animals. Members of this family are involved in mitochondrial biogenesis and G2/M phase cell cycle progression. They form a component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins [ ].

[ "GO:0003735", "GO:0005762" ]

[ "structural constituent of ribosome", "mitochondrial large ribosomal subunit" ]

[ "molecular_function", "cellular_component" ]

2

[ "PFAM", "PANTHER" ]

[ "PF09776", "PTHR34095" ]

[ "Mitoc_L55", "" ]

[ 1358, 1288 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-DME-5389840", "R-DME-5419276", "R-DME-9937383", "R-HSA-5368286", "R-HSA-5389840", "R-HSA-5419276", "R-HSA-9937383", "R-MMU-5389840", "R-MMU-5419276", "R-MMU-9937383" ]

[ "REACTOME:R-DME-5389840", "REACTOME:R-DME-5419276", "REACTOME:R-DME-9937383", "REACTOME:R-HSA-5368286", "REACTOME:R-HSA-5389840", "REACTOME:R-HSA-5419276", "REACTOME:R-HSA-9937383", "REACTOME:R-MMU-5389840", "REACTOME:R-MMU-5419276", "REACTOME:R-MMU-9937383" ]

10

[ "3j9m", "4v19", "5aj4", "5ool", "5oom", "6gaw", "6gb2", "6i9r", "6nu2", "6nu3", "6vlz", "6vmi", "6ydp", "6ydw", "6zm5", "6zm6", "6zs9", "6zsa", "6zsb", "6zsc", "6zsd", "6zse", "6zsg", "7a5f", "7a5g", "7a5h", "7a5i", "7a5j", "7a5k", "7l08", "7l20", "7nqh"...

85

[ "PUB00045030" ]

[ "15894314" ]

[ "The mitochondrial ribosome-specific MrpL55 protein is essential in Drosophila and dynamically required during development." ]

[ 2005 ]

1

[]

0

null

[ "Metazoa" ]

[ 1358 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 1, 2, 4, 1, 4 ]

6

true

Family

Large ribosomal subunit protein mL55

Ribosomal_mL55

1

IPR018616

18,616

Protein GUCD1

GUCD1

Family

2,714

false

GUCD1 contains a guanylyl cyclase domain and is found highly expressed in liver during regeneration [ ].

[]

0

[ "PFAM", "PANTHER" ]

[ "PF09778", "PTHR31400" ]

[ "Guanylate_cyc_2", "" ]

[ 2710, 2664 ]

2

[]

0

[]

0

[ "PUB00086690" ]

[ "24743017" ]

[ "NEDD4 controls the expression of GUCD1, a protein upregulated in proliferating liver cells." ]

[ 2014 ]

1

[]

0

null

[ "Candidatus Iainarchaeum sp.", "Eukaryota", "marine metagenome" ]

[ 2, 2711, 1 ]

3

[ "Arabidopsis thaliana", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 10, 2, 3, 8, 9, 3, 9, 29 ]

8

true

Family

Protein GUCD1

GUCD1

3

IPR018617

18,617

Ima1, N-terminal domain

Ima1_N

Domain

2,907

false

This domain occurs at the N terminus of the Schizosaccharomyces pombe inner nuclear membrane protein, Ima1. Ima1 interacts with other inner nuclear membrane proteins [ , ].

[]

0

[ "PFAM" ]

[ "PF09779" ]

[ "Ima1_N" ]

[ 2907 ]

1

[]

0

[]

0

[ "PUB00066721", "PUB00066722" ]

[ "21880100", "22156748" ]

[ "Inner nuclear membrane protein Ima1 is dispensable for intranuclear positioning of centromeres.", "The inner nuclear membrane proteins Man1 and Ima1 link to two different types of chromatin at the nuclear periphery in S. pombe." ]

[ 2011, 2012 ]

2

[]

0

null

[ "Eukaryota" ]

[ 2907 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 4, 3, 2, 3, 1, 3, 1 ]

8

true

Domain

Ima1, N-terminal domain

Ima1_N

9

IPR018619

18,619

Hyccin

Family

4,802

false

This family hyccin proteins (HYCC1/2) which are a component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane and it also regulates phosphatidylinositol 4-phosphate (PtdIns4P) synthesis [ ]. HYCC1 plays a key role in oligodendrocytes formation [ ] which may explain its import...

[]

0

[ "PFAM", "PANTHER" ]

[ "PF09790", "PTHR31220" ]

[ "Hyccin", "" ]

[ 4778, 4669 ]

2

[]

0

[ "5dse", "6bq1", "9b9g", "9bax" ]

4

[ "PUB00044307", "PUB00044308", "PUB00090096" ]

[ "16951682", "10910037", "26571211" ]

[ "Deficiency of hyccin, a newly identified membrane protein, causes hypomyelination and congenital cataract.", "Isolation and characterization of a novel human gene, DRCTNNB1A, the expression of which is down-regulated by beta-catenin.", "The leukodystrophy protein FAM126A (hyccin) regulates PtdIns(4)P synthesis...

[ 2006, 2000, 2016 ]

3

[]

0

null

[ "Eukaryota" ]

[ 4802 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 7, 1, 9, 1, 15, 5, 7, 11, 10 ]

9

true

Family

Hyccin

8

IPR018620

18,620

Ubiquitin 3 binding protein But2, C-terminal

Ubiquitin3-bd_protein_But2_C

Domain

2,195

false

This entry represents a presumed C-terminal domain of ubiquitin 3 binding proteins (But2). But2 is conserved in yeasts. It binds to Uba3 and is involved in the NEDD8 signalling pathway [ ].

[]

0

[ "PFAM" ]

[ "PF09792" ]

[ "But2" ]

[ 2195 ]

1

[]

0

[]

0

[ "PUB00044177" ]

[ "14623327" ]

[ "But1 and But2 proteins bind to Uba3, a catalytic subunit of E1 for neddylation, in fission yeast." ]

[ 2003 ]

1

[]

0

null

[ "Eukaryota" ]

[ 2195 ]

1

[ "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 3 ]

1

true

Domain

Ubiquitin 3 binding protein But2, C-terminal

Ubiquitin3-bd_protein_But2_C

6

IPR018621

18,621

Autophagy-related protein 31

Atg31

Family

63

false

Autophagy is an intracellular degradation system that responds to nutrient starvation. Atg31 has been shown to be required for autophagosome formation in Saccharomyces cerevisiae [ ]. It functions with Atg17 and Atg29 at the preautophagosomal structure (PAS) in order to form normal autophagosomes under starvation condi...

[ "GO:0006914", "GO:0000407" ]

[ "autophagy", "phagophore assembly site" ]

[ "biological_process", "cellular_component" ]

2

[ "PFAM" ]

[ "PF09795" ]

[ "ATG31" ]

[ 63 ]

1

[]

0

[ "4hpq", "4p1w", "5jhf" ]

3

[ "PUB00044160", "PUB00078783" ]

[ "17362880", "18287526" ]

[ "Cis1/Atg31 is required for autophagosome formation in Saccharomyces cerevisiae.", "Organization of the pre-autophagosomal structure responsible for autophagosome formation." ]

[ 2007, 2008 ]

2

[]

0

null

[ "Chryseobacterium ginsengisoli", "Saccharomycotina" ]

[ 1, 62 ]

2

[ "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)" ]

[ 1 ]

1

true

Family

Autophagy-related protein 31

Atg31

9

IPR018622

18,622

DNA damage checkpoint protein, Lcd1

DNA_damage_chkpnt_Lcd1

Family

179

false

This is a family of proteins which regulate checkpoint kinases. In Schizosaccharomyces pombe (Fission yeast) this protein is called Rad26 [ ] and in Saccharomyces cerevisiae (Baker's yeast) it is called LCD1 [ ].

[ "GO:0000077" ]

[ "DNA damage checkpoint signaling" ]

[ "biological_process" ]

1

[ "PFAM" ]

[ "PF09798" ]

[ "LCD1" ]

[ 179 ]

1

[]

0

[ "5omb", "5omc", "5omd", "5x6o", "6z2w", "6z2x", "6z3a", "7wzr", "7wzw" ]

9

[ "PUB00044330", "PUB00074970" ]

[ "11060031", "12697061" ]

[ "LCD1: an essential gene involved in checkpoint control and regulation of the MEC1 signalling pathway in Saccharomyces cerevisiae.", "Fission yeast Rad26 responds to DNA damage independently of Rad3." ]

[ 2000, 2003 ]

2

[]

0

null

[ "Eukaryota" ]

[ 179 ]

1

[ "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 1 ]

2

true

Family

DNA damage checkpoint protein, Lcd1

DNA_damage_chkpnt_Lcd1

8

IPR018624

18,624

Translocation protein Sec66

Sec66

Family

1,939

false

Members of this family of proteins are a component of the heterotetrameric Sec62/63 complex composed of SEC62, SEC63, SEC66 and SEC72. The Sec62/63 complex associates with the Sec61 complex to form the Sec complex. Sec 66 is involved in SRP-independent post-translational translocation across the endoplasmic reticulum a...

[ "GO:0031204", "GO:0031207" ]

[ "post-translational protein targeting to membrane, translocation", "Sec62/Sec63 complex" ]

[ "biological_process", "cellular_component" ]

2

[ "PFAM", "PANTHER" ]

[ "PF09802", "PTHR28229" ]

[ "Sec66", "" ]

[ 1933, 1765 ]

2

[]

0

[ "5l0w", "6n3q", "6nd1", "7aft", "7kah", "7kai", "7kaj", "7kak", "7kal", "7kam", "7kan", "7kao", "7kap", "7kaq", "7kar", "7kas", "7kat", "7kau", "7kb5" ]

19

[ "PUB00044482", "PUB00044483", "PUB00044484", "PUB00044485" ]

[ "8257795", "8257794", "2000150", "7758110" ]

[ "Structural and functional characterization of Sec66p, a new subunit of the polypeptide translocation apparatus in the yeast endoplasmic reticulum.", "Suppression of a sec63 mutation identifies a novel component of the yeast endoplasmic reticulum translocation apparatus.", "Assembly of yeast Sec proteins involv...

[ 1993, 1993, 1991, 1995 ]

4

[]

0

null

[ "Eukaryota", "Plebeiibacterium sediminum" ]

[ 1938, 1 ]

2

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 1, 1 ]

3

true

Family

Translocation protein Sec66

Sec66

7

IPR018625

18,625

Protein Pet100

Pet100

Family

3,047

false

Pet100 is a chaperone required for the assembly of cytochrome c oxidase [ ]. The human Pet100 homologue (also known as C19orf79) has been shown to be located in the mitochondrial inner membrane and forms a ~300kDa subcomplex with mitochondrial complex IV subunits [ ].

[ "GO:0033617", "GO:0005739" ]

[ "mitochondrial respiratory chain complex IV assembly", "mitochondrion" ]

[ "biological_process", "cellular_component" ]

2

[ "PFAM", "PANTHER" ]

[ "PF09803", "PTHR33968" ]

[ "Pet100", "" ]

[ 3020, 2306 ]

2

[ "REACTOME" ]

[ "R-HSA-9864848" ]

[ "REACTOME:R-HSA-9864848" ]

1

[]

0

[ "PUB00075399", "PUB00075400" ]

[ "11498004", "24462369" ]

[ "Structure and function of Pet100p, a molecular chaperone required for the assembly of cytochrome c oxidase in Saccharomyces cerevisiae.", "A founder mutation in PET100 causes isolated complex IV deficiency in Lebanese individuals with Leigh syndrome." ]

[ 2001, 2014 ]

2

[]

0

null

[ "Eukaryota" ]

[ 3047 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 7, 1, 1, 1, 9, 3, 1, 2, 5, 1, 3 ]

11

true

Family

Protein Pet100

Pet100

2

IPR018626

18,626

Protein LCHN/Anr2

LCHN/Anr2

Family

3,057

false

This entry include LCHN (also known as DENN domain-containing protein 11) from animals and Anr2 from budding yeasts. LCHN may play a role in neuritogenesis, as well as in neuronal recovery and/or restructuring in the hippocampus following transient cerebral ischemia [ ]. The function of Anr2 is not clear.

[]

0

[ "PFAM" ]

[ "PF09804" ]

[ "DENND11" ]

[ 3057 ]

1

[]

0

[]

0

[ "PUB00092489" ]

[ "17394467" ]

[ "Isolation and characterization of LCHN: a novel factor induced by transient global ischemia in the adult rat hippocampus." ]

[ 2007 ]

1

[]

0

null

[ "Eukaryota" ]

[ 3057 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 2, 2, 1, 2, 1, 1 ]

7

true

Family

Protein LCHN/Anr2

LCHN/Anr2

8

IPR018627

18,627

Elongator complex protein 6

ELP6

Family

3,760

false

This entry represents Elongator complex protein 6 (ELP6). Elongator is a 6 subunit protein complex highly conserved in eukaryotes. The human Elongator six-subunit complex, known as holo-Elongator, has histone acetyltransferase activity directed against histone H3 and H4 [ , ]. It consists of two subcomplexes, a core su...

[ "GO:0002098", "GO:0033588" ]

[ "tRNA wobble uridine modification", "elongator holoenzyme complex" ]

[ "biological_process", "cellular_component" ]

2

[ "PFAM", "PANTHER" ]

[ "PF09807", "PTHR16184" ]

[ "ELP6", "" ]

[ 2802, 3681 ]

2

[ "REACTOME" ]

[ "R-HSA-3214847" ]

[ "REACTOME:R-HSA-3214847" ]

1

[ "4a8j", "4ejs", "8asv", "8at6" ]

4

[ "PUB00008616", "PUB00019998", "PUB00043577", "PUB00043578", "PUB00074321", "PUB00074325", "PUB00086633", "PUB00086635" ]

[ "10024884", "11689709", "11904415", "15769872", "11714725", "22556426", "22889844", "23165209" ]

[ "Elongator, a multisubunit component of a novel RNA polymerase II holoenzyme for transcriptional elongation.", "Characterization of a six-subunit holo-elongator complex required for the regulated expression of a group of genes in Saccharomyces cerevisiae.", "Elongator is a histone H3 and H4 acetyltransferase im...

[ 1999, 2001, 2002, 2005, 2002, 2012, 2012, 2012 ]

8

[]

0

null

[ "Eukaryota" ]

[ 3760 ]

1

[ "Arabidopsis thaliana", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "...

[ 7, 1, 2, 10, 4, 1, 5, 3, 1, 1, 8 ]

11

true

Family

Elongator complex protein 6

ELP6

4

IPR018628

18,628

Cytochrome c oxidase assembly factor 3, mitochondrial, coiled-coil domain

Coa3_CC

Domain

3,060

false

This entry represents a coiled-coil domain found in cytochrome c oxidase assembly factor 3 and homologues. Cytochrome c oxidase assembly factor 3, previously known as coiled coil domain-containing protein 56 (CCDC56), plays a critical role in the biogenesis and activity of cytochrome c oxidase (COX) [ ].

[]

0

[ "PFAM" ]

[ "PF09813" ]

[ "Coa3_cc" ]

[ 3060 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-9864848", "R-DME-9864848", "R-DRE-9864848", "R-HSA-9864848", "R-MMU-9864848" ]

[ "REACTOME:R-BTA-9864848", "REACTOME:R-DME-9864848", "REACTOME:R-DRE-9864848", "REACTOME:R-HSA-9864848", "REACTOME:R-MMU-9864848" ]

5

[]

0

[ "PUB00075670" ]

[ "22610097" ]

[ "Coiled coil domain-containing protein 56 (CCDC56) is a novel mitochondrial protein essential for cytochrome c oxidase function." ]

[ 2012 ]

1

[]

0

null

[ "Eukaryota", "Pseudomonadota" ]

[ 3038, 22 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Schizosaccharomyces pombe (stra...

[ 4, 1, 4, 1, 1, 2, 1, 6, 2, 1, 5 ]

11

true

Domain

Cytochrome c oxidase assembly factor 3, mitochondrial, coiled-coil domain

Coa3_CC

5

IPR018629

18,629

XK-related protein

XK-rel

Family

11,004

false

This family is represented by the multipass membrane protein XK, which may be involved in sodium-dependent transport of neutral amino acids or oligopeptides. It forms a heterodimer with Kell. In humans, Kell is an 93kDa type II membrane glycoprotein with endothelin-3-converting enzyme activity that is linked by a singl...

[ "GO:0016020" ]

[ "membrane" ]

[ "cellular_component" ]

1

[ "PFAM" ]

[ "PF09815" ]

[ "XK-related" ]

[ 11004 ]

1

[ "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-375276", "R-MMU-375276", "R-RNO-375276" ]

[ "REACTOME:R-HSA-375276", "REACTOME:R-MMU-375276", "REACTOME:R-RNO-375276" ]

3

[ "7dce", "7p14", "7p16", "8xej", "9boj" ]

5

[ "PUB00044544", "PUB00044545", "PUB00081187", "PUB00081188", "PUB00100790", "PUB00100791" ]

[ "8004674", "7737196", "25231987", "23845944", "32845802", "28881496" ]

[ "Isolation of the gene for McLeod syndrome that encodes a novel membrane transport protein.", "Purification and partial characterization of the erythrocyte Kx protein deficient in McLeod patients.", "Exposure of phosphatidylserine by Xk-related protein family members during apoptosis.", "Xk-related protein 8 ...

[ 1994, 1995, 2014, 2013, 2020, 2017 ]

6

[]

0

null

[ "Eukaryota", "bird metagenome" ]

[ 11003, 1 ]

2

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 28, 5, 30, 16, 22 ]

6

true

Family

XK-related protein

XK-rel

6

IPR018630

18,630

RZZ complex, subunit Zwilch

Zwilch

Family

1,727

false

The protein Zwilch is an essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. It is required for the assembly of the dynein-dynactin, Mad2 complexes and spindly/CG15415 onto kinetochores [ , , ].

[ "GO:0007093", "GO:1990423" ]

[ "mitotic cell cycle checkpoint signaling", "RZZ complex" ]

[ "biological_process", "cellular_component" ]

2

[ "PFAM", "PANTHER" ]

[ "PF09817", "PTHR15995" ]

[ "Zwilch", "" ]

[ 1693, 1694 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-141444", "R-BTA-2467813", "R-BTA-2500257", "R-BTA-5663220", "R-BTA-68877", "R-BTA-9648025", "R-HSA-141444", "R-HSA-2467813", "R-HSA-2500257", "R-HSA-5663220", "R-HSA-68877", "R-HSA-9648025", "R-MMU-141444", "R-MMU-2467813", "R-MMU-2500257", "R-MMU-5663220", "R-MMU-68877", "R...

[ "REACTOME:R-BTA-141444", "REACTOME:R-BTA-2467813", "REACTOME:R-BTA-2500257", "REACTOME:R-BTA-5663220", "REACTOME:R-BTA-68877", "REACTOME:R-BTA-9648025", "REACTOME:R-HSA-141444", "REACTOME:R-HSA-2467813", "REACTOME:R-HSA-2500257", "REACTOME:R-HSA-5663220", "REACTOME:R-HSA-68877", "REACTOME:R-HS...

24

[ "3if8", "7qpg" ]

2

[ "PUB00044111", "PUB00054075", "PUB00054076" ]

[ "17576797", "12686595", "15886105" ]

[ "Spindly, a novel protein essential for silencing the spindle assembly checkpoint, recruits dynein to the kinetochore.", "Zwilch, a new component of the ZW10/ROD complex required for kinetochore functions.", "Recruitment of Mad2 to the kinetochore requires the Rod/Zw10 complex." ]

[ 2007, 2003, 2005 ]

3

[]

0

null

[ "Eukaryota" ]

[ 1727 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 1, 2, 5, 10, 3 ]

6

true

Family

RZZ complex, subunit Zwilch

Zwilch

8

IPR018632

18,632

C-terminal AAA-associated domain

AAA-associated_dom_C

Family

2,566

false

This had been thought to be an ATPase domain of ABC-transporter proteins. However, only one member has any trans-membrane regions. It is associated with an upstream ATP-binding cassette family .

[]

0

[ "PFAM" ]

[ "PF09821" ]

[ "AAA_assoc_C" ]

[ 2566 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "ecological metagenomes" ]

[ 149, 2381, 17, 19 ]

4

[]

0

true

Family

C-terminal AAA-associated domain

AAA-associated_dom_C

4

IPR018633

18,633

Domain of unknown function DUF2357

DUF2357

Domain

1,492

false

This entry was previously the N-terminal portion of DUF524 ( ) before it was split into two. This domain has no known function. It is predicted to adopt an all β secondary structure pattern followed by mainly α-helical structures [ ].

[]

0

[ "PFAM" ]

[ "PF09823" ]

[ "DUF2357" ]

[ 1492 ]

1

[]

0

[]

0

[ "PUB00044133" ]

[ "17584917" ]

[ "Realm of PD-(D/E)XK nuclease superfamily revisited: detection of novel families with modified transitive meta profile searches." ]

[ 2007 ]

1

[]

0

null

[ "Bacteria", "Methanobacteriota", "unclassified sequences" ]

[ 1440, 40, 12 ]

3

[]

0

true

Domain

Domain of unknown function DUF2357

DUF2357

8

IPR018635

18,635

Uncharacterised protein family UPF0319

UPF0319

Family

3,400

false

The proteins in this entry are functionally uncharacterised.

[]

0

[ "HAMAP", "PFAM", "PANTHER" ]

[ "MF_00789", "PF09829", "PTHR38108" ]

[ "UPF0319", "DUF2057", "" ]

[ 1552, 3396, 3118 ]

3

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "metagenomes" ]

[ 3393, 7 ]

2

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Uncharacterised protein family UPF0319

UPF0319

6

IPR018636

18,636

Protein of unknown function DUF2058

DUF2058

Family

4,360

false

This protein family represents various prokaryotic proteins, including Uncharacterized protein YaiL fom Escherichia coli (strain K12). It has no known function.

[]

0

[ "PFAM" ]

[ "PF09831" ]

[ "DUF2058" ]

[ 4360 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 4311, 9, 40 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Protein of unknown function DUF2058

DUF2058

8

IPR018637

18,637

Domain of unknown function DUF2059

DUF2059

Domain

6,389

false

This entry represents a domain predominantly found in bacterial proteins, including PA0856 from Pseudomonas aeruginosa ( ). It shows an all-α structure.

[]

0

[ "PFAM" ]

[ "PF09832" ]

[ "DUF2059" ]

[ 6389 ]

1

[]

0

[ "2x3o", "3oao", "6f03" ]

3

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 6278, 61, 50 ]

3

[ "Homo sapiens" ]

[ 1 ]

1

true

Domain

Domain of unknown function DUF2059

DUF2059

2

IPR018638

18,638

Domain of unknown function DUF2061, membrane

DUF2061_membrane

Domain

3,708

false

This domain, found in various prokaryotic proteins, has no known function.

[]

0

[ "PFAM" ]

[ "PF09834" ]

[ "DUF2061" ]

[ 3708 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 145, 3366, 84, 19, 94 ]

5

[]

0

true

Domain

Domain of unknown function DUF2061, membrane

DUF2061_membrane

8

IPR018639

18,639

Domain of unknown function DUF2062

DUF2062

Domain

8,691

false

This domain, found in various prokaryotic proteins, has no known function. It is found at the C-terminal of family 2 glycosyltransferase proteins, in addition to proteins of unknown function.

[]

0

[ "PFAM" ]

[ "PF09835" ]

[ "DUF2062" ]

[ 8691 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Halobacteriales", "unclassified sequences" ]

[ 7862, 555, 146, 128 ]

4

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 7, 2, 8 ]

3

true

Domain

Domain of unknown function DUF2062

DUF2062

3

IPR018640

18,640

HvfC, N-terminal domain

HvfC_N

Domain

6,675

false

This entry describes the N-terminal domain in HvfC ( ), NGO_1945 ( , ), BufC1 and various other proteins partnered with MNIO family peptide modification enzymes. HvfC, as described in Haemophilus influenzae, is a partner protein to the multinuclear nonheme iron-dependent oxidase (MNIO) enzyme HvfB , and participates in...

[]

0

[ "PFAM" ]

[ "PF09836" ]

[ "DUF2063" ]

[ 6675 ]

1

[]

0

[ "3dee" ]

1

[ "PUB00057687", "PUB00161749", "PUB00161768", "PUB00161769" ]

[ "20944208", "39602266", "31427451", "38968106" ]

[ "The structure of the first representative of Pfam family PF09836 reveals a two-domain organization and suggests involvement in transcriptional regulation.", "A widespread family of ribosomal peptide metallophores involved in bacterial adaptation to metal stress.", "Discovery and Contribution of Nontypeable Hae...

[ 2010, 2024, 2019, 2024 ]

4

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 6614, 6, 55 ]

3

[]

0

true

Domain

HvfC, N-terminal domain

HvfC_N

1

IPR018641

18,641

Transferase 1, rSAM/selenodomain-associated

Trfase_1_rSAM/seldom-assoc

Family

6,910

false

Many members of this protein family show strongly correlated phylogenetic distribution, and in most cases co-clustering, with an unusual radical SAM enzyme ( ) involved in arsenosugar biosynthesis [ ] whose C-terminal domain often contains a selenocysteine residue. Other members of the conserved gene neighbourhood incl...

[]

0

[ "PFAM", "PANTHER", "NCBIFAM" ]

[ "PF09837", "PTHR36529", "TIGR04282" ]

[ "DUF2064", "", "glyco_like_cofC" ]

[ 6642, 6638, 3539 ]

3

[ "GP" ]

[ "GenProp1053" ]

[ "GP:GenProp1053" ]

1

[ "3cgx" ]

1

[ "PUB00105561" ]

[ "30525501" ]

[ "Identification of Steps in the Pathway of Arsenosugar Biosynthesis." ]

[ 2019 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "Methanobacteriati", "unclassified sequences" ]

[ 6262, 201, 332, 115 ]

4

[]

0

true

Family

Transferase 1, rSAM/selenodomain-associated

Trfase_1_rSAM/seldom-assoc

1

IPR018643

18,643

Protein of unknown function DUF2069, membrane

DUF2069_membrane

Family

3,974

false

This family of prokaryotic proteins has no known function but is thought to be a membrane protein.

[]

0

[ "PFAM" ]

[ "PF09842" ]

[ "DUF2069" ]

[ 3974 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Knufia peltigerae", "unclassified sequences" ]

[ 3930, 1, 43 ]

3

[]

0

true

Family

Protein of unknown function DUF2069, membrane

DUF2069_membrane

1

IPR018644

18,644

Protein of unknown function DUF2071

DUF2071

Family

5,319

false

This conserved protein, similar to YgjF, has no known function.

[]

0

[ "PFAM", "PANTHER" ]

[ "PF09844", "PTHR39186" ]

[ "DUF2071", "" ]

[ 5319, 4264 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "metagenomes" ]

[ 487, 4726, 44, 62 ]

4

[]

0

true

Family

Protein of unknown function DUF2071

DUF2071

8

IPR018645

18,645

Origin-associated protein OapC-like

OapC-like

Family

545

false

This entry includes archaeal Zinc-ribbon containing proteins which are mostly uncharacterised. Some members of this entry have been described as OapC/ArvC, encoded by oapC gene which is part of the three-gene cluster oapABC (origin-associated proteins), involved in generation of extracellular vesicles (arv, archaeal ve...

[]

0

[ "PFAM" ]

[ "PF09845" ]

[ "OapC" ]

[ 545 ]

1

[]

0

[]

0

[ "PUB00154442", "PUB00154443" ]

[ "31769790", "38408251" ]

[ "Bioinformatic and genetic characterization of three genes localized adjacent to the major replication origin of Haloferax volcanii.", "Extracellular vesicle formation in <i>Euryarchaeota</i> is driven by a small GTPase." ]

[ 2019, 2024 ]

2

[]

0

null

[ "Archaea", "Bacteria", "Rhizophagus irregularis", "ecological metagenomes" ]

[ 528, 6, 1, 10 ]

4

[]

0

true

Family

Origin-associated protein OapC-like

OapC-like

6

IPR018646

18,646

Membrane protein of 12 TMs

12TM_1

Family

802

false

This family carries twelve transmembrane regions. It does not have any characteristic nucleotide-binding-domains of the GxSGSGKST type, so it may not be an ATP-binding cassette transporter. However, it may well be a transporter of some description. ABC transporters always have two nucleotide binding domains; this has t...

[]

0

[ "PFAM" ]

[ "PF09847" ]

[ "12TM_1" ]

[ 802 ]

1

[]

0

[]

0

[]

0

[]

[ "IPR054100" ]

0

1

0

[ "Archaea", "Bacteria", "ecological metagenomes" ]

[ 113, 670, 19 ]

3

[]

0

true

Family

Membrane protein of 12 TMs

12TM_1

2

IPR018647

18,647

Schlafen group 3-like, DNA/RNA helicase domain

SLFN_3-like_DNA/RNA_helicase

Domain

5,895

false

This domain, found in group 3 of Schlafen proteins from mammals, including Schlafen 5, 8, 9, 11 and 13, represents the helicase domain. Schlafen proteins are involved in the control of cell proliferation, induction of immune responses, and in the regulation of viral replication [ , , , ]. These proteins inhibit DNA rep...

[]

0

[ "PFAM" ]

[ "PF09848" ]

[ "SLFN-g3_helicase" ]

[ 5895 ]

1

[]

0

[ "7zel", "7zep", "7zes", "9erd", "9ere", "9erf", "9gmw", "9gmx" ]

8

[ "PUB00055954", "PUB00070625", "PUB00070629", "PUB00098266" ]

[ "15351786", "23570387", "18355440", "31504772" ]

[ "Modulation of T cell development and activation by novel members of the Schlafen (slfn) gene family harbouring an RNA helicase-like motif.", "The schlafen family of proteins and their regulation by interferons.", "Subcellular localization of the Schlafen protein family.", "A protein architecture guided scree...

[ 2004, 2013, 2008, 2019 ]

4

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Siphoviridae sp. ctQLz13", "unclassified sequences" ]

[ 70, 5064, 701, 1, 59 ]

5

[ "Homo sapiens", "Mus musculus", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)" ]

[ 5, 12, 5, 1 ]

4

true

Domain

Schlafen group 3-like, DNA/RNA helicase domain

SLFN_3-like_DNA/RNA_helicase

3

IPR018649

18,649

SHOCT domain

SHOCT

Domain

17,971

false

The Short C-terminal (SHOCT) domain is widespread in bacteria but is missing from the most commonly studied model organisms, despite being present in closely related species. It's predominantly C-terminal location, co-occurrence with numerous other domains and short size is reminiscent of the Gram-positive anchor motif...

[]

0

[ "PFAM" ]

[ "PF09851" ]

[ "SHOCT" ]

[ 17971 ]

1

[]

0

[]

0

[ "PUB00072411" ]

[ "23451277" ]

[ "The SHOCT domain: a widespread domain under-represented in model organisms." ]

[ 2013 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 1931, 15432, 237, 56, 315 ]

5

[]

0

true

Domain

SHOCT domain

SHOCT

8

IPR018650

18,650

Sulfolobus virus STSV1, Orf64

STSV1_Orf64

Family

2,987

false

This entry is represented by Sulfolobus virus STSV1, Orf64. The characteristics of the protein distribution suggest prophage matches in addition to the phage matches. This entry contains a family of various integral membrane proteins with no known function.

[]

0

[ "PFAM" ]

[ "PF09852" ]

[ "DUF2079" ]

[ 2987 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "metagenomes" ]

[ 130, 2769, 2, 86 ]

4

[]

0

true

Family

Sulfolobus virus STSV1, Orf64

STSV1_Orf64

2

IPR018653

18,653

Short-chain fatty acyl coenzyme A regulators, C-terminal

ScfR_C

Domain

6,632

false

This domain is found at the C-terminal end of various short-chain fatty acyl coenzyme A regulators (ScfRs) from bacteria [ ], including HTH-type transcriptional regulators PrpR and RamB from Mycobacterium tuberculosis. PrpR (propionate regulator) plays a key role in the regulation of the expression of enzymes involved ...

[]

0

[ "PFAM" ]

[ "PF09856" ]

[ "ScfRs" ]

[ 6632 ]

1

[]

0

[ "6cyj", "6cyy", "6cz6", "6d2s" ]

4

[ "PUB00074927", "PUB00074929", "PUB00076849", "PUB00100702", "PUB00100703" ]

[ "19767422", "22916289", "26170412", "31504787", "24705740" ]

[ "Role of the transcriptional regulator RamB (Rv0465c) in the control of the glyoxylate cycle in Mycobacterium tuberculosis.", "A novel role of the PrpR as a transcription factor involved in the regulation of methylcitrate pathway in Mycobacterium tuberculosis.", "Transcriptional Regulation by the Short-Chain Fa...

[ 2009, 2012, 2015, 2019, 2014 ]

5

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 6592, 6, 34 ]

3

[]

0

true

Domain

Short-chain fatty acyl coenzyme A regulators, C-terminal

ScfR_C

6

IPR018654

18,654

Putative toxin of bacterial toxin-antitoxin pair

YjhX_toxin

Family

1,542

false

YjhX_toxin is a putative toxin of a bacterial toxin-antitoxin pair [ ].

[]

0

[ "HAMAP", "NCBIFAM", "PFAM" ]

[ "MF_00827", "NF010240", "PF09857" ]

[ "UPF0386", "PRK13687.1", "YjhX_toxin" ]

[ 1415, 1506, 1542 ]

3

[]

0

[]

0

[ "PUB00075651" ]

[ "21927020" ]

[ "Regulation of growth and death in Escherichia coli by toxin-antitoxin systems." ]

[ 2011 ]

1

[]

0

null

[ "Bacteria", "ecological metagenomes" ]

[ 1540, 2 ]

2

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Putative toxin of bacterial toxin-antitoxin pair

YjhX_toxin

1

IPR018655

18,655

Protein of unknown function DUF2086

DUF2086

Family

3,701

false

This is a family of prokaryotic proteins. They are predicted to catalyse oxidative demethylation of damaged bases in DNA [ ].

[]

0

[ "PFAM" ]

[ "PF09859" ]

[ "Oxygenase-NA" ]

[ 3701 ]

1

[]

0

[]

0

[ "PUB00062298" ]

[ "23022560" ]

[ "A new family of bacterial DNA repair proteins annotated by the integration of non-homology, distant homology and structural bioinformatic methods." ]

[ 2012 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "ecological metagenomes" ]

[ 3649, 49, 3 ]

3

[]

0

true

Family

Protein of unknown function DUF2086

DUF2086

7

IPR018657

18,657

LarA-like, N-terminal

LarA-like_N

Domain

5,284

false

This entry represents the N-terminal domain of LarA and related proteins. LarA is a nickel-dependent lactate racemase from the larA-E operon of Lactobacillus plantarum, whereas LarB, LarC and LarE are accessory proteins required for the incorporation of Ni in the lactate racemase apoprotein [ ]. LarA contains 18 β-stra...

[ "GO:0050043" ]

[ "lactate racemase activity" ]

[ "molecular_function" ]

1

[ "PFAM" ]

[ "PF09861" ]

[ "Lar_N" ]

[ 5284 ]

1

[]

0

[ "2yjg", "4nar", "5huq", "6c1w", "6d6z", "7s91", "8ezf", "8ezh", "8ezi", "9eia", "9eid", "9eif", "9q3j", "9q3k" ]

14

[ "PUB00085157" ]

[ "24710389" ]

[ "Lactate racemase is a nickel-dependent enzyme activated by a widespread maturation system." ]

[ 2014 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 295, 4594, 87, 308 ]

4

[]

0

true

Domain

LarA-like, N-terminal

LarA-like_N

6

IPR018658

18,658

Domain of unknown function DUF2089

DUF2089

Domain

2,334

false

This domain is found in various hypothetical prokaryotic proteins. It occurs as a fusion of ZnR+HTH+SHOCT-like

[]

0

[ "PFAM" ]

[ "PF09862" ]

[ "DUF2089" ]

[ 2334 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Geodia barretti", "Methanobacteriota", "metagenomes" ]

[ 2284, 1, 14, 35 ]

4

[]

0

true

Domain

Domain of unknown function DUF2089

DUF2089

8

IPR018659

18,659

Domain of unknown function DUF2090

DUF2090

Domain

3,451

false

This domain, found in various prokaryotic carbohydrate kinases, has no known function.

[]

0

[ "PFAM" ]

[ "PF09863" ]

[ "DUF2090" ]

[ 3451 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Candidatus Iainarchaeum sp.", "Opisthokonta", "unclassified sequences" ]

[ 3423, 4, 3, 21 ]

4

[]

0

true

Domain

Domain of unknown function DUF2090

DUF2090

4

IPR018660

18,660

C-type lysozyme inhibitor

MliC

Domain

6,665

false

Lysozymes are ancient and important components of the innate immune system of animals that hydrolyse peptidoglycan, the major bacterial cell wall polymer. Various mechanisms have evolved by which bacteria can evade this bactericidal enzyme, one being the production of lysozyme inhibitors. MliC (membrane bound lysozyme ...

[]

0

[ "PFAM" ]

[ "PF09864" ]

[ "MliC" ]

[ 6665 ]

1

[]

0

[ "2f09", "3f6z", "3oe3", "4mir", "4mis", "4ml7" ]

6

[ "PUB00051886", "PUB00054072", "PUB00083126" ]

[ "19028453", "18369469", "26589796" ]

[ "Structural basis for the recognition of lysozyme by MliC, a periplasmic lysozyme inhibitor in Gram-negative bacteria.", "A new family of lysozyme inhibitors contributing to lysozyme tolerance in gram-negative bacteria.", "Lipoprotein LprI of Mycobacterium tuberculosis Acts as a Lysozyme Inhibitor." ]

[ 2009, 2008, 2016 ]

3

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 6631, 6, 28 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Domain

C-type lysozyme inhibitor

MliC

1

IPR018661

18,661

Protein of unknown function DUF2093

DUF2093

Family

1,825

false

This family of various hypothetical prokaryotic proteins has no known function.

[]

0

[ "PFAM" ]

[ "PF09866" ]

[ "DUF2093" ]

[ 1825 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Alphaproteobacteria", "ecological metagenomes" ]

[ 1801, 24 ]

2

[]

0

true

Family

Protein of unknown function DUF2093

DUF2093

5

IPR018662

18,662

Protein of unknown function DUF2095

DUF2095

Family

119

false

This domain, found in various hypothetical archaeal proteins, has no known function.

[]

0

[ "PFAM" ]

[ "PF09868" ]

[ "DUF2095" ]

[ 119 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "marine sediment metagenome" ]

[ 105, 14 ]

2

[]

0

true

Family

Protein of unknown function DUF2095

DUF2095

3

IPR018664

18,664

Protein of unknown function DUF2103, metal-binding

DUF2103_metal-binding

Family

930

false

This family of various putative metal binding prokaryotic proteins has no known function.

[]

0

[ "PFAM" ]

[ "PF09876" ]

[ "DUF2103" ]

[ 930 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Methanobacteriota", "ecological metagenomes" ]

[ 438, 37, 453, 2 ]

4

[]

0

true

Family

Protein of unknown function DUF2103, metal-binding

DUF2103_metal-binding

6

IPR018665

18,665

Putative type II restriction enzyme MjaORF1200P-like

MJ1199-like

Family

156

false

This entry represents Putative type II restriction enzyme MjaORF1200P (MJ1199) and Putative type II restriction enzyme ApeKORF2002P (APE_2001.1) found in archaea. MJ1199 is a putative type II restriction enzyme, its methylase would be M.MjaORF1200P [ ] [ ]. APE_2001.1 is also a putative type II restriction enzyme, whos...

[]

0

[ "PFAM" ]

[ "PF09895" ]

[ "DUF2122" ]

[ 156 ]

1

[]

0

[]

0

[ "PUB00099965" ]

[ "12654995" ]

[ "A nomenclature for restriction enzymes, DNA methyltransferases, homing endonucleases and their genes." ]

[ 2003 ]

1

[]

0

null

[ "Aquifex aeolicus", "Archaea" ]

[ 1, 155 ]

2

[]

0

true

Family

Putative type II restriction enzyme MjaORF1200P-like

MJ1199-like

6

IPR018666

18,666

Protein of unknown function DUF2125

DUF2125

Family

2,761

false

This family of conserved hypothetical proteins has no known function.

[]

0

[ "PFAM" ]

[ "PF09898" ]

[ "DUF2125" ]

[ 2761 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Symbiodiniaceae", "metagenomes" ]

[ 2731, 3, 27 ]

3

[]

0

true

Family

Protein of unknown function DUF2125

DUF2125

9

IPR018667

18,667

Domain of unknown function DUF2126

DUF2126

Domain

4,329

false

This domain is found in bacterial transglutaminase and transglutaminase-like proteins. Their exact function is, as yet, unknown.

[]

0

[ "PFAM" ]

[ "PF09899" ]

[ "DUF2126" ]

[ 4329 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 4291, 9, 29 ]

3

[]

0

true

Domain

Domain of unknown function DUF2126

DUF2126

5

IPR018668

18,668

DNA-binding protein VF530-like

DNA-binding_VF530-like

Family

5,175

false

This entry includes the DNA-binding protein VF530 from Vibrio fischeri. VF530 contains a unique four-helix motif that shows some similarity to the C-terminal double-stranded DNA (dsDNA) binding domain of RecA, as well as other nucleic acid binding domains [ ].

[ "GO:0003677" ]

[ "DNA binding" ]

[ "molecular_function" ]

1

[ "PFAM" ]

[ "PF09905" ]

[ "VF530" ]

[ 5175 ]

1

[]

0

[ "2jvw" ]

1

[ "PUB00066059" ]

[ "21905121" ]

[ "Solution NMR structure of VF0530 from Vibrio fischeri reveals a nucleic acid-binding function." ]

[ 2011 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "ecological metagenomes" ]

[ 5119, 9, 47 ]

3

[]

0

true

Family

DNA-binding protein VF530-like

DNA-binding_VF530-like

9

IPR018669

18,669

Toxin-antitoxin system, mRNA interferase HigB

Toxin_HigB

Family

4,926

false

This entry represents mRNA interferase HigB from Escherichia coli and similar bacterial proteins. HigB is the toxin of the HigB-HigA toxin-antitoxin (TA) system, acting as a translation-dependent mRNA interferase. HigB inhibits protein synthesis by cleaving translated mRNAs within the coding region [ , ]. The crystal s...

[ "GO:0003723", "GO:0004519", "GO:0090304", "GO:0110001" ]

[ "RNA binding", "endonuclease activity", "nucleic acid metabolic process", "toxin-antitoxin complex" ]

[ "molecular_function", "molecular_function", "biological_process", "cellular_component" ]

4

[ "PFAM" ]

[ "PF09907" ]

[ "HigB_toxin" ]

[ 4926 ]

1

[]

0

[ "5ifg", "5ycl", "6kml", "6kmq" ]

4

[ "PUB00054169", "PUB00088843", "PUB00100106", "PUB00100108" ]

[ "19943910", "27601326", "33000860", "24257752" ]

[ "Three new RelE-homologous mRNA interferases of Escherichia coli differentially induced by environmental stresses.", "Structural insight into the E. coli HigBA complex.", "2.09 A Resolution structure of E. coli HigBA toxin-antitoxin complex reveals an ordered DNA-binding domain and intrinsic dynamics in antitox...

[ 2010, 2016, 2020, 2014 ]

4

[]

0

null

[ "Bacteria", "Opisthokonta", "Viruses", "unclassified sequences" ]

[ 4849, 8, 11, 58 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Toxin-antitoxin system, mRNA interferase HigB

Toxin_HigB

7

IPR018671

18,671

Protein of unknown function DUF2138

DUF2138

Family

754

false

This entry contains uncharacterised proteins found in Proteobacteria, including Uncharacterized protein YfaA from Escherichia coli (strain K12).

[]

0

[ "NCBIFAM", "PFAM" ]

[ "NF008500", "PF09909" ]

[ "PRK11410.1", "DUF2138" ]

[ 637, 754 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "human gut metagenome" ]

[ 750, 4 ]

2

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Protein of unknown function DUF2138

DUF2138

1

IPR018672

18,672

Protein of unknown function DUF2140

DUF2140

Family

2,082

false

This protein family contains uncharacterised proteins found in Firmicutes, including Uncharacterized protein YpmS from Bacillus subtilis (strain 168).

[]

0

[ "PFAM" ]

[ "PF09911" ]

[ "DUF2140" ]

[ 2082 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacillota", "Spodoptera exigua", "bioreactor metagenome" ]

[ 2079, 1, 2 ]

3

[]

0

true

Family

Protein of unknown function DUF2140

DUF2140

6

IPR018673

18,673

Protein of unknown function DUF2141

DUF2141

Family

4,814

false

This family of conserved hypothetical proteins has no known function.

[]

0

[ "PFAM" ]

[ "PF09912" ]

[ "DUF2141" ]

[ 4814 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 4738, 25, 51 ]

3

[]

0

true

Family

Protein of unknown function DUF2141

DUF2141

3

IPR018677

18,677

Domain of unknown function DUF2157

DUF2157

Domain

4,117

false

This domain, found in various hypothetical prokaryotic proteins, has no known function.

[]

0

[ "PFAM" ]

[ "PF09925" ]

[ "DUF2157" ]

[ 4117 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Stenosarchaea group", "unclassified sequences" ]

[ 4039, 2, 35, 41 ]

4

[]

0

true

Domain

Domain of unknown function DUF2157

DUF2157

4

IPR018678

18,678

Protein of unknown function DUF2160, transmembrane

DUF2160_TM

Family

2,909

false

The members of this family of hypothetical prokaryotic proteins have no known function. It is thought that they are transmembrane proteins, but their function has not been inferred yet.

[]

0

[ "PFAM" ]

[ "PF09928" ]

[ "DUF2160" ]

[ 2909 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Symbiodinium necroappetens", "unclassified sequences" ]

[ 2876, 1, 32 ]

3

[]

0

true

Family

Protein of unknown function DUF2160, transmembrane

DUF2160_TM

5

IPR018679

18,679

Putative PD-(D/E)XK phosphodiesterase (DUF2161)

DUF2161

Family

1,669

false

This family of proteins is functionally uncharacterised. This family of proteins is found in prokaryotes. Advanced homology-detection methods supported with superfamily-wide domain architecture and horizontal gene transfer analyses s have established this family to be a member of the PD-(D/E)XK superfamily.

[]

0

[ "PFAM" ]

[ "PF09929" ]

[ "DUF2161" ]

[ 1669 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "ecological metagenomes" ]

[ 1654, 3, 12 ]

3

[]

0

true

Family

Putative PD-(D/E)XK phosphodiesterase (DUF2161)

DUF2161

6

IPR018680

18,680

Protein of unknown function DUF2164

DUF2164

Family

3,392

false

This family of various hypothetical prokaryotic proteins has no known function.

[]

0

[ "PFAM" ]

[ "PF09932" ]

[ "DUF2164" ]

[ 3392 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Methanomicrobia", "ecological metagenomes" ]

[ 3361, 2, 7, 22 ]

4

[]

0

true

Family

Protein of unknown function DUF2164

DUF2164

8

IPR018681

18,681

Protein of unknown function DUF2165, transmembrane

DUF2165_transmembrane

Family

2,090

false

This family of various hypothetical prokaryotic proteins has no known function.

[]

0

[ "PFAM" ]

[ "PF09933" ]

[ "DUF2165" ]

[ 2090 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 2079, 2, 9 ]

3

[]

0

true

Family

Protein of unknown function DUF2165, transmembrane

DUF2165_transmembrane

1

IPR018682

18,682

Protein of unknown function DUF2167, membrane

DUF2167_membr

Family

2,084

false

This family of various hypothetical membrane-anchored prokaryotic proteins has no known function.

[]

0

[ "PFAM" ]

[ "PF09935" ]

[ "DUF2167" ]

[ 2084 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "ecological metagenomes" ]

[ 2075, 3, 6 ]

3

[]

0

true

Family

Protein of unknown function DUF2167, membrane

DUF2167_membr

8

IPR018683

18,683

Domain of unknown function DUF2169

DUF2169

Domain

3,101

false

This domain, found in various hypothetical prokaryotic proteins, has no known function.

[]

0

[ "PFAM" ]

[ "PF09937" ]

[ "DUF2169" ]

[ 3101 ]

1

[]

0

[ "8vth" ]

1

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 3054, 3, 44 ]

3

[]

0

true

Domain

Domain of unknown function DUF2169

DUF2169

9

IPR018685

18,685

Protein of unknown function DUF2173

DUF2173

Family

225

false

This family of various hypothetical prokaryotic proteins has no known function.

[]

0

[ "PFAM", "PIRSF" ]

[ "PF09941", "PIRSF006821" ]

[ "DUF2173", "UCP006821" ]

[ 225, 153 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Pseudomonadati", "ecological metagenomes" ]

[ 82, 127, 16 ]

3

[]

0

true

Family

Protein of unknown function DUF2173

DUF2173

7

IPR018686

18,686

Protein of unknown function DUF2175

DUF2175

Family

87

false

This family of various hypothetical archaeal proteins has no known function.

[]

0

[ "PFAM" ]

[ "PF09943" ]

[ "DUF2175" ]

[ 87 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Myoviridae sp. ctagO6", "mine drainage metagenome" ]

[ 83, 2, 1, 1 ]

4

[]

0

true

Family

Protein of unknown function DUF2175

DUF2175

1

IPR018687

18,687

Protein of unknown function DUF2177, membrane

DUF2177_membr

Family

2,386

false

This family of putative membrane proteins has no known function.

[]

0

[ "PFAM" ]

[ "PF09945" ]

[ "DUF2177" ]

[ 2386 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Viruses", "metagenomes" ]

[ 2163, 41, 21, 161 ]

4

[]

0

true

Family

Protein of unknown function DUF2177, membrane

DUF2177_membr

5

IPR018688

18,688

Copper chaperone PpoB2-like

PpoB2-like

Family

2,790

false

This family includes Copper chaperone PpoB2 from Marinomonas mediterranea and similar prokaryotic sequences. PpoB2 is a membrane copper transporter involved in the delivery of this ion to the PpoB1 tyrosinase ( ) [ ].

[]

0

[ "PFAM" ]

[ "PF09948" ]

[ "PpoB2" ]

[ 2790 ]

1

[]

0

[]

0

[ "PUB00160081" ]

[ "17600068" ]

[ "Involvement of a novel copper chaperone in tyrosinase activity and melanin synthesis in Marinomonas mediterranea." ]

[ 2007 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Geodia barretti", "unclassified sequences" ]

[ 95, 2635, 1, 59 ]

4

[]

0

true

Family

Copper chaperone PpoB2-like

PpoB2-like

9

IPR018689

18,689

Immunity protein Imm33 domain

Imm33_dom

Domain

1,304

false

This domain has been identified as a putative family of immunity proteins found in bacterial toxin/antitoxin systems [ ]. This domain was previously called DUF2185.

[]

0

[ "PFAM" ]

[ "PF09951" ]

[ "Imm33" ]

[ 1304 ]

1

[]

0

[]

0

[ "PUB00066726" ]

[ "22731697" ]

[ "Polymorphic toxin systems: Comprehensive characterization of trafficking modes, processing, mechanisms of action, immunity and ecology using comparative genomics." ]

[ 2012 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "Methanobacteriati", "metagenomes" ]

[ 1283, 10, 5, 6 ]

4

[]

0

true

Domain

Immunity protein Imm33 domain

Imm33_dom

5

IPR018691

18,691

Protein of unknown function DUF2188

DUF2188

Family

5,225

false

DUF3892 is related to the truncated RNaseH fold-containing ribosome hibernation factors. It has been predicted to function as a possible conflict effector domain at the ribosome, based on comparable genome contextual associations with DUF2188, including repeated association with nucleotide-activated effector conflict s...

[]

0

[ "PFAM" ]

[ "PF09954" ]

[ "DUF2188" ]

[ 5225 ]

1

[]

0

[]

0

[ "PUB00097693" ]

[ "32868406" ]

[ "Identification of Uncharacterized Components of Prokaryotic Immune Systems and Their Diverse Eukaryotic Reformulations." ]

[ 2020 ]

1

[]

0

null

[ "Bacteria", "Caudoviricetes", "Eukaryota", "Methanobacteriati", "metagenomes" ]

[ 5151, 11, 3, 27, 33 ]

5

[]

0

true

Family

Protein of unknown function DUF2188

DUF2188

4

IPR018692

18,692

Predicted integral membrane protein DUF2189

DUF2189

Family

4,261

false

This family includes several hypothetical prokaryotic proteins. Some are described as putative cytochrome c oxidases.

[]

0

[ "PFAM" ]

[ "PF09955" ]

[ "DUF2189" ]

[ 4261 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 4224, 4, 33 ]

3

[]

0

true

Family

Predicted integral membrane protein DUF2189

DUF2189

1

IPR018693

18,693

Protein of unknown function DUF2192

DUF2192

Family

146

false

This family of various hypothetical archaeal proteins has no known function.

[]

0

[ "PFAM" ]

[ "PF09958" ]

[ "DUF2192" ]

[ 146 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Thermoprotei" ]

[ 19, 127 ]

2

[]

0

true

Family

Protein of unknown function DUF2192

DUF2192

2

IPR018695

18,695

Protein of unknown function DUF2194

DUF2194

Family

651

false

This family of prokaryotic proteins has no known function; however it may be a membrane protein.

[]

0

[ "PFAM" ]

[ "PF09960" ]

[ "DUF2194" ]

[ 651 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "ecological metagenomes" ]

[ 646, 5 ]

2

[]

0

true

Family

Protein of unknown function DUF2194

DUF2194

6

IPR018696

18,696

Protein of unknown function DUF2195

DUF2195

Family

404

false

This family of various bacterial proteins has no known function.

[]

0

[ "PFAM" ]

[ "PF09961" ]

[ "DUF2195" ]

[ 404 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Pseudomonadota" ]

[ 404 ]

1

[]

0

true

Family

Protein of unknown function DUF2195

DUF2195

1

IPR018697

18,697

Protein of unknown function DUF2199

DUF2199

Family

1,304

false

This domain has no known function.

[]

0

[ "PFAM" ]

[ "PF09965" ]

[ "DUF2199" ]

[ 1304 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "ecological metagenomes" ]

[ 1296, 4, 4 ]

3

[]

0

true

Family

Protein of unknown function DUF2199

DUF2199

2

IPR018698

18,698

VWA-like domain

VWA-like_dom

Domain

3,944

false

This domain, found in various hypothetical bacterial proteins, has no known function. However, it is clearly related to the VWA domain.

[]

0

[ "PFAM" ]

[ "PF09967" ]

[ "DUF2201" ]

[ 3944 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Protostomia", "Viruses", "unclassified sequences" ]

[ 28, 3523, 3, 276, 114 ]

5

[]

0

true

Domain

VWA-like domain

VWA-like_dom

2

IPR018699

18,699

Protein of unknown function DUF2203

DUF2203

Family

1,501

false

This family has no known function.

[]

0

[ "PFAM", "PIRSF" ]

[ "PF09969", "PIRSF016498" ]

[ "DUF2203", "UCP016498" ]

[ 1501, 1302 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Opisthokonta", "ecological metagenomes" ]

[ 153, 1297, 2, 49 ]

4

[]

0

true

Family

Protein of unknown function DUF2203

DUF2203

2

IPR018700

18,700

Protein of unknown function DUF2204

DUF2204

Family

613

false

This family of hypothetical prokaryotic proteins has no known function. However, this family was identified as belonging to the nucleotidyltransferase superfamily [ , ].

[]

0

[ "PFAM" ]

[ "PF09970" ]

[ "DUF2204" ]

[ 613 ]

1

[]

0

[]

0

[ "PUB00066751" ]

[ "19833706" ]

[ "Comprehensive classification of nucleotidyltransferase fold proteins: identification of novel families and their representatives in human." ]

[ 2009 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "ecological metagenomes" ]

[ 126, 466, 11, 10 ]

4

[]

0

true

Family

Protein of unknown function DUF2204

DUF2204

1

IPR018702

18,702

Domain of unknown function DUF2207

DUF2207

Domain

6,454

false

This domain with no known function is located at the N-terminal domain of a group of uncharacterised prokaryotic proteins, including the predicted membrane protein YciQ from Escherichia coli.

[]

0

[ "PFAM" ]

[ "PF09972" ]

[ "DUF2207" ]

[ 6454 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 166, 6198, 10, 80 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Domain

Domain of unknown function DUF2207

DUF2207

5

IPR018704

18,704

Ancillary SecYEG translocon subunit/Cell division coordinator CpoB, TPR domain

SecYEG/CpoB_TPR

Domain

11,098

false

This is the TPR domain found in ancillary SecYEG translocon subunit and cell division coordinator CpoB. CpoB coordinates the complexes involved in septal peptidoglycan synthesis (PBP1B-LpoB complex) and outer membrane constriction (Tol system), which contributes to maintain the integrity of the cell envelope during div...

[]

0

[ "PFAM" ]

[ "PF09976" ]

[ "TPR_21" ]

[ 11098 ]

1

[]

0

[]

0

[ "PUB00084209", "PUB00097230" ]

[ "25951518", "24855643" ]

[ "Coordination of peptidoglycan synthesis and outer membrane constriction during Escherichia coli cell division.", "YfgM is an ancillary subunit of the SecYEG translocon in Escherichia coli." ]

[ 2015, 2014 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "Methanobacteriota", "unclassified sequences" ]

[ 10762, 143, 4, 189 ]

4

[ "Escherichia coli (strain K12)", "Zea mays" ]

[ 1, 6 ]

2

true

Domain

Ancillary SecYEG translocon subunit/Cell division coordinator CpoB, TPR domain

SecYEG/CpoB_TPR

5

IPR018705

18,705

Domain of unknown function DUF2134, membrane

DUF2134_membrane

Domain

1,629

false

This domain, found in various hypothetical prokaryotic proteins, is likely to be involved in Flp pilus biogenesis.

[]

0

[ "PFAM" ]

[ "PF09977" ]

[ "Tad_C" ]

[ 1629 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Kayeltresvirus", "Methanothrix thermoacetophila (strain DSM 6194 / JCM 14653 / NBRC 101360 / PT)", "metagenomes" ]

[ 1608, 3, 4, 1, 13 ]

5

[]

0

true

Domain

Domain of unknown function DUF2134, membrane

DUF2134_membrane

3

IPR018706

18,706

Protein of unknown function DUF2214, membrane

DUF2214_membrane

Family

1,723

false

This family has no known function.

[]

0

[ "PFAM" ]

[ "PF09980" ]

[ "DUF2214" ]

[ 1723 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 1630, 80, 13 ]

3

[]

0

true

Family

Protein of unknown function DUF2214, membrane

DUF2214_membrane

7

IPR018707

18,707

Lipid A deacylase LpxR

LpxR

Family

3,732

false

This entry represents a group of bacterial proteins that include the lipid A deacylase LpxR from Salmonella typhimurium. LpxR is an outer membrane protein that catalyses the removal of the the 3'-acyloxyacyl moiety from lipid A. It requires Ca2+ for its activity. This enzyme folds into a 12-stranded antiparallel β-barr...

[]

0

[ "PFAM" ]

[ "PF09982" ]

[ "LpxR" ]

[ 3732 ]

1

[]

0

[ "3fid" ]

1

[ "PUB00051973" ]

[ "19174515" ]

[ "Active-site architecture and catalytic mechanism of the lipid A deacylase LpxR of Salmonella typhimurium." ]

[ 2009 ]

1

[]

0

null

[ "Bacteria", "Dikarya", "metagenomes", "uncultured Caudovirales phage" ]

[ 3707, 3, 21, 1 ]

4

[]

0

true

Family

Lipid A deacylase LpxR

LpxR

3