LiteFold/InterPro · Datasets at Hugging Face

IPR019069

19,069

Restriction endonuclease, type II, ScaI

Restrct_endonuc_II_ScaI

Family

87

false

There are four classes of restriction endonucleases: types I, II, III and IV. All types of enzymes recognise specific short DNA sequences and carry out the endonucleolytic cleavage of DNA to give specific double-stranded fragments with terminal 5'-phosphates. They differ in their recognition sequence, subunit compositi...

[]

0

[ "PFAM" ]

[ "PF09569" ]

[ "RE_ScaI" ]

[ 87 ]

1

[]

0

[]

0

[ "PUB00035691", "PUB00035692", "PUB00035693", "PUB00035694", "PUB00035705", "PUB00035707" ]

[ "15770420", "14576294", "11827971", "11557805", "15121719", "12665693" ]

[ "Type II restriction endonucleases: structure and mechanism.", "Diversity of type II restriction endonucleases that require two DNA recognition sites.", "Evolutionary relationship between different subgroups of restriction endonucleases.", "Structure and function of type II restriction endonucleases.", "S-A...

[ 2005, 2003, 2002, 2001, 2004, 2003 ]

6

[]

0

null

[ "Bacteria", "uncultured marine group II/III euryarchaeote AD1000_88_C03" ]

[ 86, 1 ]

2

[]

0

true

Family

Restriction endonuclease, type II, ScaI

Restrct_endonuc_II_ScaI

5

IPR019070

19,070

Type II restriction endonuclease SinI

Restrct_endonuc_II_SinI

Family

142

false

This entry includes the restriction endonuclease SinI, which recognises and cleaves the double-stranded sequence G^GWCC. There are four classes of restriction endonucleases: types I, II, III and IV. All types of enzymes recognise specific short DNA sequences and carry out the endonucleolytic cleavage of DNA to give spe...

[ "GO:0003677", "GO:0009036", "GO:0009307" ]

[ "DNA binding", "type II site-specific deoxyribonuclease activity", "DNA restriction-modification system" ]

[ "molecular_function", "molecular_function", "biological_process" ]

3

[ "PFAM" ]

[ "PF09570" ]

[ "RE_SinI" ]

[ 142 ]

1

[]

0

[ "6g3b", "6s48", "6s58" ]

3

[ "PUB00035691", "PUB00035692", "PUB00035693", "PUB00035694", "PUB00035705", "PUB00035707" ]

[ "15770420", "14576294", "11827971", "11557805", "15121719", "12665693" ]

[ "Type II restriction endonucleases: structure and mechanism.", "Diversity of type II restriction endonucleases that require two DNA recognition sites.", "Evolutionary relationship between different subgroups of restriction endonucleases.", "Structure and function of type II restriction endonucleases.", "S-A...

[ 2005, 2003, 2002, 2001, 2004, 2003 ]

6

[]

0

null

[ "Bacteria", "Ferroplasma acidiphilum", "hydrothermal vent metagenome" ]

[ 140, 1, 1 ]

3

[]

0

true

Family

Type II restriction endonuclease SinI

Restrct_endonuc_II_SinI

1

IPR019071

19,071

Restriction endonuclease, type II, XcyI-like

Restrct_endonuc_II_XcyI-like

Family

97

false

This entry represents the restriction endonuclease XcyI, which recognises and cleaves the double-stranded sequence C^CCGGG and Type II restriction enzyme Cfr9I. There are four classes of restriction endonucleases: types I, II, III and IV. All types of enzymes recognise specific short DNA sequences and carry out the end...

[ "GO:0000287", "GO:0003677", "GO:0009036", "GO:0009307" ]

[ "magnesium ion binding", "DNA binding", "type II site-specific deoxyribonuclease activity", "DNA restriction-modification system" ]

[ "molecular_function", "molecular_function", "molecular_function", "biological_process" ]

4

[ "PFAM" ]

[ "PF09571" ]

[ "RE_XcyI" ]

[ 97 ]

1

[]

0

[]

0

[ "PUB00035691", "PUB00035692", "PUB00035693", "PUB00035694", "PUB00035705", "PUB00035707" ]

[ "15770420", "14576294", "11827971", "11557805", "15121719", "12665693" ]

[ "Type II restriction endonucleases: structure and mechanism.", "Diversity of type II restriction endonucleases that require two DNA recognition sites.", "Evolutionary relationship between different subgroups of restriction endonucleases.", "Structure and function of type II restriction endonucleases.", "S-A...

[ 2005, 2003, 2002, 2001, 2004, 2003 ]

6

[]

0

null

[ "Archaea", "Bacteria", "unclassified sequences" ]

[ 4, 90, 3 ]

3

[]

0

true

Family

Restriction endonuclease, type II, XcyI-like

Restrct_endonuc_II_XcyI-like

1

IPR019072

19,072

Restriction endonuclease, type II, XamI-like

Restrct_endonuc_II_XamI-like

Family

207

false

This entry includes the XamI restriction endonuclease which recognises GTCGAC but cleavage site unknown and Type II restriction enzyme SalI. There are four classes of restriction endonucleases: types I, II, III and IV. All types of enzymes recognise specific short DNA sequences and carry out the endonucleolytic cleavag...

[ "GO:0003677", "GO:0009036", "GO:0009307" ]

[ "DNA binding", "type II site-specific deoxyribonuclease activity", "DNA restriction-modification system" ]

[ "molecular_function", "molecular_function", "biological_process" ]

3

[ "PFAM" ]

[ "PF09572" ]

[ "RE_XamI" ]

[ 207 ]

1

[]

0

[]

0

[ "PUB00035691", "PUB00035692", "PUB00035693", "PUB00035694", "PUB00035705", "PUB00035707" ]

[ "15770420", "14576294", "11827971", "11557805", "15121719", "12665693" ]

[ "Type II restriction endonucleases: structure and mechanism.", "Diversity of type II restriction endonucleases that require two DNA recognition sites.", "Evolutionary relationship between different subgroups of restriction endonucleases.", "Structure and function of type II restriction endonucleases.", "S-A...

[ 2005, 2003, 2002, 2001, 2004, 2003 ]

6

[]

0

null

[ "Bacteria", "Stenosarchaea group", "mine drainage metagenome" ]

[ 198, 6, 3 ]

3

[]

0

true

Family

Restriction endonuclease, type II, XamI-like

Restrct_endonuc_II_XamI-like

9

IPR019073

19,073

Restriction endonuclease, type II, TaqI

Restrct_endonuc_II_TaqI

Family

63

false

There are four classes of restriction endonucleases: types I, II, III and IV. All types of enzymes recognise specific short DNA sequences and carry out the endonucleolytic cleavage of DNA to give specific double-stranded fragments with terminal 5'-phosphates. They differ in their recognition sequence, subunit compositi...

[ "GO:0003677", "GO:0009036", "GO:0009307" ]

[ "DNA binding", "type II site-specific deoxyribonuclease activity", "DNA restriction-modification system" ]

[ "molecular_function", "molecular_function", "biological_process" ]

3

[ "PFAM" ]

[ "PF09573" ]

[ "RE_TaqI" ]

[ 63 ]

1

[]

0

[]

0

[ "PUB00035691", "PUB00035692", "PUB00035693", "PUB00035694", "PUB00035705", "PUB00035707" ]

[ "15770420", "14576294", "11827971", "11557805", "15121719", "12665693" ]

[ "Type II restriction endonucleases: structure and mechanism.", "Diversity of type II restriction endonucleases that require two DNA recognition sites.", "Evolutionary relationship between different subgroups of restriction endonucleases.", "Structure and function of type II restriction endonucleases.", "S-A...

[ 2005, 2003, 2002, 2001, 2004, 2003 ]

6

[]

0

null

[ "Bacteria", "groundwater metagenome" ]

[ 62, 1 ]

2

[]

0

true

Family

Restriction endonuclease, type II, TaqI

Restrct_endonuc_II_TaqI

7

IPR019074

19,074

Spore cortex biosynthesis protein, YabQ

YabQ

Family

2,539

false

This protein is predicted to span the membrane several times. It is only found in genomes of species that perform sporulation, such as Bacillus subtilis, Clostridium tetani, and other members of the Firmicutes (low-GC Gram-positive bacteria). Mutation of this sigmaE-dependent gene blocks development of the spore cortex...

[]

0

[ "PFAM", "NCBIFAM" ]

[ "PF09578", "TIGR02893" ]

[ "Spore_YabQ", "spore_yabQ" ]

[ 2514, 2533 ]

2

[]

0

[]

0

[ "PUB00034419" ]

[ "11283287" ]

[ "The Bacillus subtilis yabQ gene is essential for formation of the spore cortex." ]

[ 2001 ]

1

[]

0

null

[ "Bacteria", "metagenomes" ]

[ 2520, 19 ]

2

[]

0

true

Family

Spore cortex biosynthesis protein, YabQ

YabQ

9

IPR019076

19,076

Sporulation lipoprotein YhcN/YlaJ-like

Spore_lipoprot_YhcN/YlaJ-like

Family

4,786

false

This entry contains YhcN and YlaJ, which are predicted lipoproteins that have been detected as spore proteins but not vegetative proteins in Bacillus subtilis [ , ]. Both appear to be expressed under control of the RNA polymerase sigma-G factor. The YlaJ-like members of this family have a low-complexity, strongly acidi...

[]

0

[ "PFAM" ]

[ "PF09580" ]

[ "Spore_YhcN_YlaJ" ]

[ 4786 ]

1

[]

0

[ "7peg" ]

1

[ "PUB00034417", "PUB00034581" ]

[ "12480901", "9611260" ]

[ "Proteomics characterization of novel spore proteins of Bacillus subtilis.", "Characterization of yhcN, a new forespore-specific gene of Bacillus subtilis." ]

[ 2002, 1998 ]

2

[]

[ "IPR014247" ]

0

1

0

[ "Bacteria", "unclassified sequences" ]

[ 4780, 6 ]

2

[]

0

true

Family

Sporulation lipoprotein YhcN/YlaJ-like

Spore_lipoprot_YhcN/YlaJ-like

3

IPR019079

19,079

Capsule synthesis protein, CapA

Capsule_synth_CapA

Domain

16,043

false

CapA is a putative poly-gamma-glutamate capsule biosynthesis protein found in bacteria. Poly-gamma-glutamate is a natural polymer that may be involved in virulence and may help bacteria survive in high salt concentrations. It is a surface-associated protein [ ].

[]

0

[ "PFAM", "SMART", "CDD" ]

[ "PF09587", "SM00854", "cd07381" ]

[ "PGA_cap", "PGA_cap", "MPP_CapA" ]

[ 15854, 15650, 13590 ]

3

[]

0

[ "2cv9", "2z06", "8gq9", "8gqa", "8gqb", "8itg", "8ith" ]

7

[ "PUB00044431" ]

[ "16689787" ]

[ "Poly-gamma-glutamate in bacteria." ]

[ 2006 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 327, 14921, 510, 15, 270 ]

5

[]

0

true

Domain

Capsule synthesis protein, CapA

Capsule_synth_CapA

9

IPR019080

19,080

YqaJ viral recombinase

YqaJ_viral_recombinase

Domain

15,240

false

Proteins containing this domain are found in many different bacterial species but is of viral origin. The protein forms an oligomer and functions as a processive alkaline exonuclease that digests linear double-stranded DNA in a Mg(2+)-dependent reaction, It has a preference for 5'-phosphorylated DNA ends. It thus forms...

[]

0

[ "PFAM" ]

[ "PF09588" ]

[ "YqaJ" ]

[ 15240 ]

1

[]

0

[ "1avq", "3slp", "3sm4", "3syy", "3sz4", "3sz5", "4wuz", "5yet", "5yeu", "6m9k" ]

10

[ "PUB00044555", "PUB00101937" ]

[ "12670970", "35461299" ]

[ "Bacteriophage SPP1 Chu is an alkaline exonuclease in the SynExo family of viral two-component recombinases.", "ASFV pD345L protein negatively regulates NF-κB signalling by inhibiting IKK kinase activity." ]

[ 2003, 2022 ]

2

[]

[ "IPR017482" ]

0

1

0

[ "Bacteria", "Eukaryota", "Methanobacteriati", "Viruses", "unclassified sequences" ]

[ 6401, 7598, 4, 798, 439 ]

5

[ "Arabidopsis thaliana", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 8, 4, 1, 1, 5, 9 ]

6

true

Domain

YqaJ viral recombinase

YqaJ_viral_recombinase

5

IPR019081

19,081

Uncharacterised protein family UPF0328

UPF0328

Family

110

false

This protein is found in eukaryotic, parasitic microsporidia. Its function is unknown.

[]

0

[ "PFAM" ]

[ "PF09591" ]

[ "DUF2463" ]

[ 110 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Opisthokonta" ]

[ 110 ]

1

[]

0

true

Family

Uncharacterised protein family UPF0328

UPF0328

6

IPR019082

19,082

Neurogenic mastermind-like, N-terminal

Mastermind-like_N

Domain

1,903

false

This entry represents the N-terminal domain found in a family of neurogenic mastermind-like proteins (MAMLs), which act as critical transcriptional co-activators for Notch signaling [ , , ]. Notch receptors are cleaved upon ligand engagement and the intracellular domain of Notch shuttles to the nucleus. MAMLs form a fu...

[ "GO:0003713", "GO:0007219", "GO:0045944", "GO:0016607" ]

[ "transcription coactivator activity", "Notch signaling pathway", "positive regulation of transcription by RNA polymerase II", "nuclear speck" ]

[ "molecular_function", "biological_process", "biological_process", "cellular_component" ]

4

[ "PFAM", "SMART" ]

[ "PF09596", "SM01275" ]

[ "MamL-1", "MamL-1" ]

[ 1893, 1856 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-1912408", "R-HSA-210744", "R-HSA-2122947", "R-HSA-2197563", "R-HSA-2644606", "R-HSA-2894862", "R-HSA-350054", "R-HSA-8941856", "R-HSA-9013508", "R-HSA-9013695", "R-HSA-9793380", "R-MMU-2122947", "R-MMU-350054", "R-MMU-8941856" ]

[ "REACTOME:R-HSA-1912408", "REACTOME:R-HSA-210744", "REACTOME:R-HSA-2122947", "REACTOME:R-HSA-2197563", "REACTOME:R-HSA-2644606", "REACTOME:R-HSA-2894862", "REACTOME:R-HSA-350054", "REACTOME:R-HSA-8941856", "REACTOME:R-HSA-9013508", "REACTOME:R-HSA-9013695", "REACTOME:R-HSA-9793380", "REACTOME:...

14

[ "2f8x", "3nbn", "3v79" ]

3

[ "PUB00033511", "PUB00044098", "PUB00045311", "PUB00045312", "PUB00045313", "PUB00045314", "PUB00045315", "PUB00045316", "PUB00045317", "PUB00045318", "PUB00045319", "PUB00100173" ]

[ "16530044", "18758478", "18758483", "16510869", "17317671", "17875709", "16880534", "17699740", "19150886", "15961999", "15546612", "12370315" ]

[ "Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes.", "More complicated than it looks: assembly of Notch pathway transcription complexes.", "Mastermind-like transcriptional co-activators: emerging roles in regulating cross talk among multiple signaling pathw...

[ 2006, 2008, 2008, 2006, 2007, 2007, 2006, 2007, 2009, 2005, 2004, 2002 ]

12

[]

0

null

[ "Eumetazoa" ]

[ 1903 ]

1

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 5, 2, 4, 4, 3 ]

5

true

Domain

Neurogenic mastermind-like, N-terminal

Mastermind-like_N

9

IPR019083

19,083

Small ribosomal subunit protein mS41, SAM domain

SAM_Ribosomal_mS41

Domain

2,462

false

This entry represents a SAM-like domain found in fungal mitoribosome protein mS41. The mitochondrion-specific ribosomal protein mS41 family comprises proteins that are integral components of the mitochondrial ribosome, also known as the mitoribosome [ , ]. These proteins play a crucial role in the dedicated translation...

[]

0

[ "PFAM", "SMART" ]

[ "PF09597", "SM01238" ]

[ "SAM_Ribosomal_mS41", "IGR" ]

[ 2452, 2365 ]

2

[]

0

[ "5mrc", "5mre", "5mrf", "6hiv", "6hiw", "6hiy", "6sga", "6sgb", "6xyw", "6yw5", "6ywe", "6ywx", "6ywy", "6z1p", "7ane", "7aor", "7pua", "7pub", "8d8j", "8d8k", "8d8l", "8om2", "8om3", "8om4", "9evs", "9gyt", "9hny" ]

27

[ "PUB00033286", "PUB00044402", "PUB00089004", "PUB00098057" ]

[ "12663529", "16552446", "25609543", "28154081" ]

[ "A Saccharomyces cerevisiae genome-wide mutant screen for altered sensitivity to K1 killer toxin.", "Telomere length as a quantitative trait: genome-wide survey and genetic mapping of telomere length-control genes in yeast.", "Organization of the mitochondrial translation machinery studied in situ by cryoelectr...

[ 2003, 2006, 2015, 2017 ]

4

[]

0

null

[ "Eukaryota" ]

[ 2462 ]

1

[ "Arabidopsis thaliana", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)", "Zea mays" ]

[ 8, 1, 6, 1, 1, 9 ]

6

true

Domain

Small ribosomal subunit protein mS41, SAM domain

SAM_Ribosomal_mS41

7

IPR019084

19,084

STM1-like, N-terminal

STM1-like_N

Domain

3,184

false

This domain is found at the N-terminal region of the Stm1 and similar proteins. Stm1 is a G4 quadraplex and purine motif triplex nucleic acid-binding protein. It has been implicated in many biological processes including apoptosis and telomere biosynthesis. Stm1 is known to interact with Cdc13 [ ], and is known to asso...

[]

0

[ "PFAM" ]

[ "PF09598" ]

[ "Stm1_N" ]

[ 3184 ]

1

[ "REACTOME", "REACTOME" ]

[ "R-SCE-114608", "R-SPO-114608" ]

[ "REACTOME:R-SCE-114608", "REACTOME:R-SPO-114608" ]

2

[ "4u3m", "4u3n", "4u3u", "4u4n", "4u4o", "4u4q", "4u4r", "4u4u", "4u4y", "4u4z", "4u50", "4u51", "4u52", "4u53", "4u55", "4u56", "4u6f", "4v88", "5dat", "5dc3", "5dge", "5dgv", "5fci", "5fcj", "5i4l", "5ndg", "5ndv", "5ndw", "5obm", "5on6", "6hhq", "7olc"...

55

[ "PUB00044501", "PUB00044502", "PUB00083147" ]

[ "12207228", "15044472", "25783413" ]

[ "STM1, a gene which encodes a guanine quadruplex binding protein, interacts with CDC13 in Saccharomyces cerevisiae.", "Stm1p, a G4 quadruplex and purine motif triplex nucleic acid-binding protein, interacts with ribosomes and subtelomeric Y' DNA in Saccharomyces cerevisiae.", "The Arabidopsis RNA-binding protei...

[ 2002, 2004, 2015 ]

3

[]

0

null

[ "Eukaryota", "Telluria group" ]

[ 3182, 2 ]

2

[ "Arabidopsis thaliana", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)", "Zea mays" ]

[ 13, 1, 8, 1, 1, 19 ]

6

true

Domain

STM1-like, N-terminal

STM1-like_N

9

IPR019087

19,087

Mediator of RNA polymerase II transcription subunit 15, N-terminal

Med15_N

Domain

1,979

false

This entry represents the N-terminal domain of human Mediator of RNA polymerase II transcription subunit 15 (MED15, also known as ARC105) and similar animal proteins. This region, of approximately 70 residue, is a three-helix bundle with marked similarity to the KIX domain [ ]. The sterol regulatory element binding pro...

[]

0

[ "PFAM" ]

[ "PF09606" ]

[ "Med15_N" ]

[ 1979 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-1989781", "R-HSA-212436", "R-HSA-381340", "R-HSA-9833110" ]

[ "REACTOME:R-HSA-1989781", "REACTOME:R-HSA-212436", "REACTOME:R-HSA-381340", "REACTOME:R-HSA-9833110" ]

4

[ "2gut", "7emf", "7ena", "7enc", "7enj", "7lbm", "8gxq", "8gxs", "8t1i", "8t1l", "8t9d", "8tqw", "8trh" ]

13

[ "PUB00041188" ]

[ "16799563" ]

[ "An ARC/Mediator subunit required for SREBP control of cholesterol and lipid homeostasis." ]

[ 2006 ]

1

[]

0

null

[ "Eukaryota" ]

[ 1979 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 9, 1, 13, 11, 9 ]

6

true

Domain

Mediator of RNA polymerase II transcription subunit 15, N-terminal

Med15_N

2

IPR019088

19,088

Conserved hypothetical protein CHP02186-related, transmembrane

CHP02186-rel_TM

Family

2,653

false

This entry consists of predicted transmembrane proteins of about 270 amino acids. They are found predominantly, though not exclusively, in alphaproteobacteria, generally only once in each genome.

[]

0

[ "PFAM", "NCBIFAM" ]

[ "PF09608", "TIGR02186" ]

[ "Alph_Pro_TM", "alph_Pro_TM" ]

[ 2653, 720 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 2617, 5, 31 ]

3

[]

0

true

Family

Conserved hypothetical protein CHP02186-related, transmembrane

CHP02186-rel_TM

3

IPR019089

19,089

Type I-G CRISPR-associated protein Csb2

Cas_Csb2

Family

576

false

The CRISPR-Cas system is a prokaryotic defence mechanism against foreign genetic elements. The key elements of this defence system are the Cas proteins and the CRISPR RNA. This entry represents a rare CRISPR-associated protein. CRISPR-associated proteins typically are found near CRISPR repeats and other CRISPR-associat...

[]

0

[ "PFAM", "NCBIFAM" ]

[ "PF09609", "TIGR02165" ]

[ "Cas_GSU0054", "cas5_6_GSU0054" ]

[ 243, 575 ]

2

[ "GP", "GP" ]

[ "GenProp0021", "GenProp0469" ]

[ "GP:GenProp0021", "GP:GenProp0469" ]

2

[]

0

[ "PUB00043286", "PUB00043287", "PUB00043288", "PUB00060621", "PUB00071890" ]

[ "17442114", "17379808", "16545108", "21699496", "24459147" ]

[ "Evolutionary conservation of sequence and secondary structures in CRISPR repeats.", "CRISPR provides acquired resistance against viruses in prokaryotes.", "A putative RNA-interference-based immune system in prokaryotes: computational analysis of the predicted enzymatic machinery, functional analogies with euka...

[ 2007, 2007, 2006, 2011, 2014 ]

5

[]

0

null

[ "Bacteria", "Methanobacteriati", "unclassified sequences" ]

[ 553, 11, 12 ]

3

[]

0

true

Family

Type I-G CRISPR-associated protein Csb2

Cas_Csb2

2

IPR019092

19,092

CRISPR system ring nuclease SSO2081-like domain

SSO2081-like_dom

Domain

578

false

This entry represents a domain found in a Cas protein family from bacteria and archaea, including the ring nuclease SSO2081 from Saccharolobus solfataricus [ ]. The CRISPR-Cas system is a prokaryotic defence mechanism against foreign genetic elements. The key elements of this defence system are the Cas proteins and the...

[]

0

[ "PFAM" ]

[ "PF09623" ]

[ "Cas_NE0113" ]

[ 578 ]

1

[]

0

[ "7ygh", "7ygl", "7yhl", "7z55", "7z56", "8htw", "9c67", "9c68", "9c69", "9c6a", "9c6c", "9c6f", "9c77", "9cdb", "9mmw", "9of1", "9ofb", "9ofc", "9ofd", "9ofe" ]

20

[ "PUB00043286", "PUB00043287", "PUB00043288", "PUB00060621", "PUB00071890", "PUB00091682" ]

[ "17442114", "17379808", "16545108", "21699496", "24459147", "30232454" ]

[ "Evolutionary conservation of sequence and secondary structures in CRISPR repeats.", "CRISPR provides acquired resistance against viruses in prokaryotes.", "A putative RNA-interference-based immune system in prokaryotes: computational analysis of the predicted enzymatic machinery, functional analogies with euka...

[ 2007, 2007, 2006, 2011, 2014, 2018 ]

6

[]

0

null

[ "Archaea", "Bacteria", "unclassified sequences" ]

[ 59, 511, 8 ]

3

[]

0

true

Domain

CRISPR system ring nuclease SSO2081-like domain

SSO2081-like_dom

9

IPR019094

19,094

Bacteriophage SP-beta, YorD

Phage_SP-beta_YorD

Domain

304

false

This entry includes the phage SPbeta protein YorD, the function of which is not known. It also contains the protein XkdW ( ) from the Phage-like element PBSX in Bacillus subtilis. XkdW is approximately 100 residues long and contains two α helices and two β strands, and is probably monomeric. XkdW is expressed in bacter...

[]

0

[ "PFAM" ]

[ "PF09636" ]

[ "XkdW" ]

[ 304 ]

1

[]

0

[ "2hg7" ]

1

[ "PUB00045435" ]

[ "125016" ]

[ "[Experimental investigations on the effectiveness of fenbendazole in parasitic helminths of the stomach, intestines and lung of cattle (author's transl)]" ]

[ 1975 ]

1

[]

0

null

[ "Bacteria", "Viruses", "unclassified sequences" ]

[ 234, 64, 6 ]

3

[]

0

true

Domain

Bacteriophage SP-beta, YorD

Phage_SP-beta_YorD

9

IPR019095

19,095

Mediator complex, subunit Med18

Mediator_Med18

Family

3,594

false

The Mediator complex is a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. The Mediator complex, having a compact confor...

[ "GO:0003712", "GO:0006357", "GO:0016592" ]

[ "transcription coregulator activity", "regulation of transcription by RNA polymerase II", "mediator complex" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PFAM", "PANTHER" ]

[ "PF09637", "PTHR13321" ]

[ "Med18", "" ]

[ 3090, 3164 ]

2

[ "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-1989781", "R-HSA-381340", "R-HSA-9833110" ]

[ "REACTOME:R-HSA-1989781", "REACTOME:R-HSA-381340", "REACTOME:R-HSA-9833110" ]

3

[ "2hzm", "2hzs", "3c0t", "3j1o", "3rj1", "4gwp", "4gwq", "4h63", "4v1o", "5n9j", "5oqm", "5sva", "5u0p", "5u0s", "6w1s", "6xp5", "7emf", "7ena", "7enc", "7enj", "7lbm", "7nvr", "7ui9", "7uif", "7uig", "7uio", "8cen", "8ceo", "8gxq", "8gxs", "8t1i", "8t1l"...

35

[ "PUB00041559" ]

[ "16964259" ]

[ "Structure and TBP binding of the Mediator head subcomplex Med8-Med18-Med20." ]

[ 2006 ]

1

[]

0

null

[ "Acidianus sulfidivorans JP7", "Eukaryota" ]

[ 1, 3593 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 2, 2, 1, 1, 2, 2, 1, 2, 2, 1, 1, 4 ]

12

true

Family

Mediator complex, subunit Med18

Mediator_Med18

2

IPR019096

19,096

YopX protein

YopX_protein

Domain

3,295

false

YopX is a protein of plasmid origin found in bacteria. It is of approx. 135 residues and is largely helical, with three identical chains probably complexing into a twelve-chain structure. Yop proteins are a subset of pathogenicity factors known as (Yersinia) outer proteins - Yops - which act as chaperones for other pro...

[]

0

[ "PFAM" ]

[ "PF09643" ]

[ "YopX" ]

[ 3295 ]

1

[]

0

[ "2i2l", "2ox7", "2p84", "2qyz" ]

4

[ "PUB00044554" ]

[ "15847602" ]

[ "Yersinia outer proteins: role in modulation of host cell signaling responses and pathogenesis." ]

[ 2005 ]

1

[]

0

null

[ "Bacteria", "Methanobacteriota", "Opisthokonta", "Viruses", "metagenomes" ]

[ 2459, 5, 4, 573, 254 ]

5

[]

0

true

Domain

YopX protein

YopX_protein

2

IPR019097

19,097

Mg296 protein

Mg296_protein

Domain

16

false

This protein of 129 residues is expressed in bacteria. It consists of three identical chains of five α helices. Two copies of each chain associate into a complex of six units of possible biological significance but of unknown function.

[]

0

[ "PFAM" ]

[ "PF09644" ]

[ "Mg296" ]

[ 16 ]

1

[]

0

[ "2i15" ]

1

[]

0

[]

0

null

[ "Mycoplasmatota" ]

[ 16 ]

1

[]

0

true

Domain

Mg296 protein

Mg296_protein

2

IPR019098

19,098

Histone chaperone domain CHZ

Histone_chaperone_domain_CHZ

Domain

2,875

false

This domain is highly conserved from yeasts to humans and is part of the chaperone protein HIRIP3 in vertebrates which interacts with the H3.3 chaperone HIRA, implicated in histone replacement during transcription. N- and C- termini of Chz family members are relatively divergent but do contain similar acidic stretches ...

[]

0

[ "PFAM", "SMART" ]

[ "PF09649", "SM01082" ]

[ "CHZ", "CHZ" ]

[ 2536, 2587 ]

2

[]

0

[ "2jss", "6ae8", "6m2m", "8qz0" ]

4

[ "PUB00044198" ]

[ "17289584" ]

[ "Chz1, a nuclear chaperone for histone H2AZ." ]

[ 2007 ]

1

[]

0

null

[ "Eukaryota", "Pseudomonadota" ]

[ 2873, 2 ]

2

[ "Arabidopsis thaliana", "Danio rerio", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (st...

[ 14, 1, 3, 1, 1, 2, 4, 1, 1, 4 ]

10

true

Domain

Histone chaperone domain CHZ

Histone_chaperone_domain_CHZ

3

IPR019099

19,099

Uncharacterised protein family PGPGW, transmembrane

Uncharacterised_PGPGW_TM

Family

4,161

false

This entry represents proteins that contain three predicted transmembrane helices and an unusual motif with consensus sequence PGPGW.

[]

0

[ "PFAM" ]

[ "PF09656" ]

[ "PGPGW" ]

[ 4161 ]

1

[]

0

[]

0

[]

0

[]

[ "IPR013434" ]

0

1

0

[ "Bacillariophyta", "Bacteria", "unclassified sequences" ]

[ 31, 3993, 137 ]

3

[]

0

true

Family

Uncharacterised protein family PGPGW, transmembrane

Uncharacterised_PGPGW_TM

4

IPR019103

19,103

Aspartic peptidase, DDI1-type

Peptidase_aspartic_DDI1-type

Domain

6,428

false

This domain is found in eukaryotic aspartyl protease DDI1 (DNA Damage Inducible protein 1; MEROPS identifier A28.001). The remarkable structural similarity between this central domain of DDI1 and the retroviral proteases suggests that DDI1 functions proteolytically during regulated protein turnover [ , ]. DDI1 has been...

[ "GO:0004190", "GO:0006508" ]

[ "aspartic-type endopeptidase activity", "proteolysis" ]

[ "molecular_function", "biological_process" ]

2

[ "PFAM", "CDD" ]

[ "PF09668", "cd05479" ]

[ "Asp_protease", "RP_DDI" ]

[ 6428, 4463 ]

2

[ "EC" ]

[ "3.4.23.-" ]

[ "EC:3.4.23.-" ]

1

[ "2i1a", "3s8i", "4rgh", "4z2z", "5yq8", "5ys4", "7d66", "7efy" ]

8

[ "PUB00041573", "PUB00078443", "PUB00082746", "PUB00082747" ]

[ "17010377", "15964793", "27528192", "27646017" ]

[ "Ddi1, a eukaryotic protein with the retroviral protease fold.", "The DNA damage-inducible UbL-UbA protein Ddi1 participates in Mec1-mediated degradation of Ho endonuclease.", "Proteasome dysfunction triggers activation of SKN-1A/Nrf1 by the aspartic protease DDI-1.", "Structural studies of the yeast DNA dama...

[ 2006, 2005, 2016, 2016 ]

4

[]

[ "IPR033821" ]

0

1

0

[ "Bacteria", "Eukaryota", "Viruses", "seawater metagenome" ]

[ 9, 6411, 7, 1 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 4, 1, 4, 1, 7, 7, 1, 2, 7, 1, 1, 5 ]

12

true

Domain

Aspartic peptidase, DDI1-type

Peptidase_aspartic_DDI1-type

9

IPR019106

19,106

Type-F conjugative transfer system pilin assembly protein TrbC

T4SS_TrbC

Family

2,730

false

This entry represents TrbC, a protein that is an essential component of the F-type conjugative pilus assembly system (aka type 4 secretion system) for the transfer of plasmid DNA [ , ]. The N-terminal portion of these proteins is heterogeneous.

[]

0

[ "PFAM" ]

[ "PF09673" ]

[ "TrbC_Ftype" ]

[ 2730 ]

1

[]

0

[]

0

[ "PUB00034396", "PUB00034399" ]

[ "16138100", "205063" ]

[ "Mobile genetic elements: the agents of open source evolution.", "[Evaluation of the alginat membrane filter method for the Enterovirus concentration in water (author's transl)]" ]

[ 2005, 1977 ]

2

[]

[ "IPR014113" ]

0

1

0

[ "Bacteria", "Eukaryota", "Methanosarcina mazei", "metagenomes" ]

[ 2693, 19, 1, 17 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Type-F conjugative transfer system pilin assembly protein TrbC

T4SS_TrbC

7

IPR019108

19,108

Cytochrome c oxidase caa3-type, assembly factor CtaG-related

Caa3_assmbl_CtaG-rel

Family

13,108

false

This entry represents the CtaG protein, required for the assembly of active caa3-type cytochrome c oxidase in Bacillus subtilis [ ], and related proteins both from Gram-positive and Gram-negative bacteria.

[]

0

[ "PFAM" ]

[ "PF09678" ]

[ "Caa3_CtaG" ]

[ 13108 ]

1

[]

0

[]

0

[ "PUB00034539" ]

[ "14766920" ]

[ "CtaG is required for formation of active cytochrome c oxidase in Bacillus subtilis." ]

[ 2004 ]

1

[]

[ "IPR014108" ]

0

1

0

[ "Bacteria", "Eukaryota", "unclassified sequences", "uncultured marine thaumarchaeote KM3_86_F11" ]

[ 12706, 11, 390, 1 ]

4

[]

0

true

Family

Cytochrome c oxidase caa3-type, assembly factor CtaG-related

Caa3_assmbl_CtaG-rel

2

IPR019109

19,109

Magnetosome protein MamF/MmsF

MamF_MmsF

Family

12,879

false

This entry, previously known as DUF4870, represents the magnetosome MamF/MmsF protein family found in magnetotactic bacteria. These membrane proteins are involved in magnetite crystal formation within magnetosome organelles [ ]. They are not essential for biomineralization, but play a major role in controlling the size...

[]

0

[ "PFAM" ]

[ "PF09685" ]

[ "MamF_MmsF" ]

[ 12879 ]

1

[]

0

[]

0

[ "PUB00106120" ]

[ "22716969" ]

[ "The magnetosome membrane protein, MmsF, is a major regulator of magnetite biomineralization in Magnetospirillum magneticum AMB-1." ]

[ 2012 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Staphylococcus phage HS15", "unclassified sequences" ]

[ 406, 12295, 41, 1, 136 ]

5

[]

0

true

Family

Magnetosome protein MamF/MmsF

MamF_MmsF

1

IPR019110

19,110

Uncharacterised protein family, RAQPRD

Uncharacterised_RAQPRD

Family

1,832

false

This entry identifies a family of proteins, around 100 amino acids in length, that include a predicted signal sequence and a perfectly conserved motif, RAQPRD, towards the C terminus. They are found in the Pseudomonas putida TOL plasmid pWW0 and in cryptic plasmid regions of Salmonella enterica subsp. enterica serovar ...

[]

0

[ "PFAM", "NCBIFAM" ]

[ "PF09686", "TIGR01690" ]

[ "Plasmid_RAQPRD", "ICE_RAQPRD" ]

[ 1832, 1662 ]

2

[ "GP" ]

[ "GenProp0855" ]

[ "GP:GenProp0855" ]

1

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 1815, 2, 15 ]

3

[]

0

true

Family

Uncharacterised protein family, RAQPRD

Uncharacterised_RAQPRD

3

IPR019111

19,111

Plasmodium RESA, N-terminal

PRESA_N

Domain

2,792

false

This entry represents the N-terminal domain of RESA (ring-infected erythrocyte surface antigen) from Plasmodium falciparum, the apicomplexan parasite that causes the most severe form of malaria in humans. The short, four-helical domain first identified in the Plasmodium export proteins PHISTa and PHISTc [ ] has been id...

[]

0

[ "PFAM" ]

[ "PF09687" ]

[ "PRESAN" ]

[ 2792 ]

1

[]

0

[ "4jle", "7d2w" ]

2

[ "PUB00053439", "PUB00093487" ]

[ "16507167", "24983468" ]

[ "Lineage-specific expansion of proteins exported to erythrocytes in malaria parasites.", "A Plasmodium falciparum PHIST protein binds the virulence factor PfEMP1 and comigrates to knobs on the host cell surface." ]

[ 2006, 2014 ]

2

[]

0

null

[ "Bacteria", "Eukaryota" ]

[ 4, 2788 ]

2

[]

0

true

Domain

Plasmodium RESA, N-terminal

PRESA_N

5

IPR019114

19,114

Chaperone lipoprotein, PulS/OutS-like

Chap_lipoprot_PulS/OutS-like

Family

1,422

false

This family comprises lipoproteins from gamma proteobacterial species: pullulanase secretion protein PulS protein of Klebsiella pneumoniae ( ), the lipoprotein OutS protein of Erwinia chrysanthemi ( ) and the functionally uncharacterised type II secretion protein EtpO ( ) from Escherichia coli O157:H7. PulS and OutS ha...

[]

0

[ "NCBIFAM", "PFAM" ]

[ "NF037975", "PF09691" ]

[ "pilot_rel_YacC", "T2SS_PulS_OutS" ]

[ 1118, 1413 ]

2

[]

0

[ "3sol", "3utk", "4a56", "4k0u", "6hcg" ]

5

[ "PUB00097456", "PUB00104493" ]

[ "22098633", "11118204" ]

[ "Pilotin-secretin recognition in the type II secretion system of Klebsiella oxytoca.", "Expression of the endogenous type II secretion pathway in Escherichia coli leads to chitinase secretion." ]

[ 2011, 2000 ]

2

[]

[ "IPR005699" ]

0

1

0

[ "Bacteria" ]

[ 1422 ]

1

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Chaperone lipoprotein, PulS/OutS-like

Chap_lipoprot_PulS/OutS-like

5

IPR019117

19,117

CRISPR-associated protein, Cmr3

CRISPR-assoc_protein_Cmr3

Family

1,096

false

The CRISPR-Cas system is a prokaryotic defence mechanism against foreign genetic elements. The key elements of this defence system are the Cas proteins and the CRISPR RNA. This entry represents a highly divergent family of Cas proteins, found in at least ten different archaeal and bacterial species, including TM1793 fr...

[]

0

[ "PFAM" ]

[ "PF09700" ]

[ "Cas_Cmr3" ]

[ 1096 ]

1

[]

0

[ "3w2v", "3w2w", "3x1l", "4h4k", "6s6b", "6s8b", "6s8e", "6s91", "6sh8", "6shb", "6sic", "9arw" ]

12

[ "PUB00043286", "PUB00043287", "PUB00043288", "PUB00060621", "PUB00071890" ]

[ "17442114", "17379808", "16545108", "21699496", "24459147" ]

[ "Evolutionary conservation of sequence and secondary structures in CRISPR repeats.", "CRISPR provides acquired resistance against viruses in prokaryotes.", "A putative RNA-interference-based immune system in prokaryotes: computational analysis of the predicted enzymatic machinery, functional analogies with euka...

[ 2007, 2007, 2006, 2011, 2014 ]

5

[]

[ "IPR010165" ]

0

1

0

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 85, 995, 2, 14 ]

4

[]

0

true

Family

CRISPR-associated protein, Cmr3

CRISPR-assoc_protein_Cmr3

1

IPR019121

19,121

CRISPR-associated protein, CXXC-CXXC domain

CRISPR-assoc_CXXC-CXXC_dom

Domain

406

false

The CRISPR-Cas system is a prokaryotic defence mechanism against foreign genetic elements. The key elements of this defence system are the Cas proteins and the CRISPR RNA. This entry represents a conserved domain of about 65 amino acids found in otherwise highly divergent proteins encoded in CRISPR-associated regions. ...

[]

0

[ "PFAM" ]

[ "PF09706" ]

[ "Cas_CXXC_CXXC" ]

[ 406 ]

1

[]

0

[]

0

[ "PUB00043286", "PUB00043287", "PUB00043288", "PUB00060621", "PUB00071890" ]

[ "17442114", "17379808", "16545108", "21699496", "24459147" ]

[ "Evolutionary conservation of sequence and secondary structures in CRISPR repeats.", "CRISPR provides acquired resistance against viruses in prokaryotes.", "A putative RNA-interference-based immune system in prokaryotes: computational analysis of the predicted enzymatic machinery, functional analogies with euka...

[ 2007, 2007, 2006, 2011, 2014 ]

5

[]

0

null

[ "Bacteria", "Methanobacteriati", "hot springs metagenome" ]

[ 358, 47, 1 ]

3

[]

0

true

Domain

CRISPR-associated protein, CXXC-CXXC domain

CRISPR-assoc_CXXC-CXXC_dom

1

IPR019127

19,127

Exosortase

Family

5,950

false

Proteins in this family are mostly designated exosortase, analogous to the sortase in cell wall sorting mediated by LPXTG domains in Gram-positive bacteria. Members of this family are integral membrane proteins with eight predicted transmembrane helices in common. The best characterised protein in this entry is EpsH of...

[]

0

[ "PFAM" ]

[ "PF09721" ]

[ "Exosortase_EpsH" ]

[ 5950 ]

1

[ "EC" ]

[ "3.4.22.-" ]

[ "EC:3.4.22.-" ]

1

[]

0

[ "PUB00021014" ]

[ "12624205" ]

[ "Genes involved in the synthesis of the exopolysaccharide methanolan by the obligate methylotroph Methylobacillus sp strain 12S." ]

[ 2003 ]

1

[]

[ "IPR013426", "IPR014522", "IPR017541", "IPR022504", "IPR022505", "IPR026323", "IPR026430", "IPR026441", "IPR026478", "IPR026485", "IPR027557", "IPR027567", "IPR030996", "IPR031006" ]

0

14

0

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 730, 5104, 5, 111 ]

4

[]

0

true

Family

Exosortase

4

IPR019128

19,128

Sister chromatid cohesion protein Dcc1

Dcc1

Family

4,263

false

Sister chromatid cohesion protein Dcc1 is a component of the RFC-like complex Ctf18-RFC. This complex is required for the efficient establishment of chromosome cohesion during S-phase and may load or unload Pol30/PCNA. During a clamp loading circle, the RFC:clamp complex binds to DNA and the recognition of the double-s...

[ "GO:0007064", "GO:0031390" ]

[ "mitotic sister chromatid cohesion", "Ctf18 RFC-like complex" ]

[ "biological_process", "cellular_component" ]

2

[ "PFAM", "PANTHER" ]

[ "PF09724", "PTHR13395" ]

[ "Dcc1", "" ]

[ 4261, 3623 ]

2

[ "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-174411", "R-MMU-174411", "R-XTR-174411" ]

[ "REACTOME:R-HSA-174411", "REACTOME:R-MMU-174411", "REACTOME:R-XTR-174411" ]

3

[ "5msm", "5msn", "5okc", "5oki", "6s1c", "6s2e", "6s2f", "8tw9", "8twa" ]

9

[ "PUB00045276", "PUB00045277" ]

[ "11389843", "15964801" ]

[ "Identification of RFC(Ctf18p, Ctf8p, Dcc1p): an alternative RFC complex required for sister chromatid cohesion in S. cerevisiae.", "Replication protein A-directed unloading of PCNA by the Ctf18 cohesion establishment complex." ]

[ 2001, 2005 ]

2

[]

0

null

[ "Eukaryota" ]

[ 4263 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 6, 1, 2, 1, 1, 3, 1, 4, 6, 1, 1, 3 ]

12

true

Family

Sister chromatid cohesion protein Dcc1

Dcc1

7

IPR019129

19,129

Folate-sensitive fragile site protein Fra10Ac1

Folate-sensitive_fs_Fra10Ac1

Family

3,075

false

This entry represents the full-length proteins in which, in higher eukaryotes, the nested domain EDSLL lies. Fra10Ac1 is a highly conserved nuclear protein of unknown function that is highly expressed in brain tissue [ ].

[]

0

[ "PFAM" ]

[ "PF09725" ]

[ "Fra10Ac1" ]

[ 3075 ]

1

[]

0

[]

0

[ "PUB00044268" ]

[ "15203205" ]

[ "Folate-sensitive fragile site FRA10A is due to an expansion of a CGG repeat in a novel gene, FRA10AC1, encoding a nuclear protein." ]

[ 2004 ]

1

[]

0

null

[ "Eukaryota" ]

[ 3075 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 8, 1, 1, 4, 1, 1, 5, 7, 8 ]

9

true

Family

Folate-sensitive fragile site protein Fra10Ac1

Folate-sensitive_fs_Fra10Ac1

4

IPR019130

19,130

Macoilin

Family

2,995

false

Macoilin has several highly conserved predicted transmembrane domains towards the N terminus and the coiled-coil regions at the C terminus. It is a conserved nervous system-specific ER membrane protein that regulates neuronal functions [ , ].

[ "GO:0023041", "GO:0030867" ]

[ "neuronal signal transduction", "rough endoplasmic reticulum membrane" ]

[ "biological_process", "cellular_component" ]

2

[ "PFAM", "PANTHER", "PANTHER" ]

[ "PF09726", "PTHR13289", "PTHR47464" ]

[ "Macoilin", "", "" ]

[ 2593, 677, 2299 ]

3

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-8980692", "R-HSA-9013106", "R-MMU-8980692", "R-MMU-9013106", "R-RNO-8980692", "R-SSC-8980692", "R-SSC-9013106" ]

[ "REACTOME:R-HSA-8980692", "REACTOME:R-HSA-9013106", "REACTOME:R-MMU-8980692", "REACTOME:R-MMU-9013106", "REACTOME:R-RNO-8980692", "REACTOME:R-SSC-8980692", "REACTOME:R-SSC-9013106" ]

7

[]

0

[ "PUB00075592", "PUB00075593" ]

[ "21437263", "21589894" ]

[ "Macoilin, a conserved nervous system-specific ER membrane protein that regulates neuronal excitability.", "Novel and conserved protein macoilin is required for diverse neuronal functions in Caenorhabditis elegans." ]

[ 2011, 2011 ]

2

[]

0

null

[ "Eukaryota" ]

[ 2995 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus" ]

[ 1, 10, 11, 3, 8, 2, 4 ]

7

true

Family

Macoilin

4

IPR019133

19,133

MICOS complex subunit MIC60

MIC60

Family

6,442

false

MICOS complex subunit MIC60 (also known as Mitofilin) is a component of the MICOS complex which controls mitochondrial cristae morphology, maintenance of junctions, inner membrane architecture, and formation of contact sites to the outer membrane [ , ]. Mitofilin is enriched in the narrow space between the inner bounda...

[]

0

[ "PFAM", "PANTHER" ]

[ "PF09731", "PTHR15415" ]

[ "Mitofilin", "" ]

[ 6390, 5706 ]

2

[ "REACTOME" ]

[ "R-HSA-8949613" ]

[ "REACTOME:R-HSA-8949613" ]

1

[ "7puz", "7pv1" ]

2

[ "PUB00044364", "PUB00044365", "PUB00083140", "PUB00083141" ]

[ "8886976", "15647377", "22114354", "25781180" ]

[ "Molecular characterization of mitofilin (HMP), a mitochondria-associated protein with predicted coiled coil and intermembrane space targeting domains.", "The mitochondrial inner membrane protein mitofilin controls cristae morphology.", "MINOS1 is a conserved component of mitofilin complexes and required for mi...

[ 1996, 2005, 2012, 2015 ]

4

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 676, 5760, 6 ]

3

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 4, 2, 3, 3, 12, 15, 1, 3, 8, 1, 1, 13 ]

12

true

Family

MICOS complex subunit MIC60

MIC60

7

IPR019134

19,134

Splicing factor Cactin, C-terminal

Cactin_C

Domain

4,444

false

This entry represents the C-terminal β-sandwich domain of the splicing factor cactin [ ], which is necessary for the association of cactin with the IkappaB protein cactus, as one of the intracellular members of the Rel complex. The Rel (NF-kappaB) pathway is conserved in invertebrates and vertebrates. In mammals, it co...

[ "GO:0005515" ]

[ "protein binding" ]

[ "molecular_function" ]

1

[ "PFAM" ]

[ "PF09732" ]

[ "CactinC_cactus" ]

[ 4444 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-CEL-72163", "R-DME-72163", "R-DRE-72163", "R-HSA-72163", "R-MMU-72163" ]

[ "REACTOME:R-CEL-72163", "REACTOME:R-DME-72163", "REACTOME:R-DRE-72163", "REACTOME:R-HSA-72163", "REACTOME:R-MMU-72163" ]

5

[ "6qdv", "7w5a", "7w5b", "8c6j", "9fmd" ]

5

[ "PUB00044178", "PUB00101922", "PUB00101935", "PUB00101936" ]

[ "10842059", "30705154", "28062851", "20829348" ]

[ "Cactin, a conserved protein that interacts with the Drosophila IkappaB protein cactus and modulates its function.", "A human postcatalytic spliceosome structure reveals essential roles of metazoan factors for exon ligation.", "Human cactin interacts with DHX8 and SRRM2 to assure efficient pre-mRNA splicing and...

[ 2000, 2019, 2017, 2010 ]

4

[]

0

null

[ "Eukaryota" ]

[ 4444 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Schizosaccharomyces pombe (stra...

[ 3, 1, 3, 4, 4, 2, 1, 6, 3, 1, 4 ]

11

true

Domain

Splicing factor Cactin, C-terminal

Cactin_C

9

IPR019136

19,136

Transcription factor IIIC subunit 5, HTH domain

TF_IIIC_su-5_HTH

Domain

4,791

false

Transcription factor IIIC (TFIIIC) is a multisubunit DNA binding factor that serves as a dynamic platform for assembly of pre-initiation complexes on class III genes. This entry represents subunit Tfc1/Sfc1 (also known as the tau 95 subunit) which holds a key position in TFIIIC, exerting both upstream and downstream in...

[]

0

[ "PFAM" ]

[ "PF09734" ]

[ "Tau95" ]

[ 4791 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-DDI-76061", "R-DDI-76066", "R-HSA-749476", "R-HSA-76061", "R-HSA-76066", "R-MMU-76061", "R-MMU-76066", "R-SCE-76066", "R-SPO-76061", "R-SPO-76066" ]

[ "REACTOME:R-DDI-76061", "REACTOME:R-DDI-76066", "REACTOME:R-HSA-749476", "REACTOME:R-HSA-76061", "REACTOME:R-HSA-76066", "REACTOME:R-MMU-76061", "REACTOME:R-MMU-76066", "REACTOME:R-SCE-76066", "REACTOME:R-SPO-76061", "REACTOME:R-SPO-76066" ]

10

[ "4bji", "6yj6", "8clk", "8ffz", "9gck", "9gi4" ]

6

[ "PUB00045150" ]

[ "12533520" ]

[ "The tau95 subunit of yeast TFIIIC influences upstream and downstream functions of TFIIIC.DNA complexes." ]

[ 2003 ]

1

[]

0

null

[ "Eukaryota" ]

[ 4791 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 16, 1, 1, 3, 7, 2, 2, 2, 2, 1, 1, 4 ]

12

true

Domain

Transcription factor IIIC subunit 5, HTH domain

TF_IIIC_su-5_HTH

1

IPR019137

19,137

Nck-associated protein 1

Nck-associated_protein-1

Family

6,106

false

Nck-associated protein 1 is part of lamellipodial complex that controls Rac-dependent actin remodeling [ , ]. It associates preferentially with the first SH3 domain of Nck and is a component of the WAVE2 complex composed of ABI1, CYFIP1/SRA1, NCKAP1/NAP1 and WASF2/WAVE2. It is also a component of the WAVE1 complex comp...

[]

0

[ "PFAM", "PANTHER" ]

[ "PF09735", "PTHR12093" ]

[ "Nckap1", "" ]

[ 6054, 5998 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-CEL-2029482", "R-CEL-5663213", "R-CEL-6798695", "R-CEL-9013149", "R-CEL-9013404", "R-CEL-9013423", "R-DDI-2029482", "R-DDI-5663213", "R-DDI-6798695", "R-DDI-9013149", "R-DDI-9013404", "R-DDI-9013423", "R-DME-2029482", "R-DME-4420097", "R-DME-5663213", "R-DME-6798695", "R-DME-90131...

[ "REACTOME:R-CEL-2029482", "REACTOME:R-CEL-5663213", "REACTOME:R-CEL-6798695", "REACTOME:R-CEL-9013149", "REACTOME:R-CEL-9013404", "REACTOME:R-CEL-9013423", "REACTOME:R-DDI-2029482", "REACTOME:R-DDI-5663213", "REACTOME:R-DDI-6798695", "REACTOME:R-DDI-9013149", "REACTOME:R-DDI-9013404", "REACTOM...

40

[ "3p8c", "4n78", "7usc", "7usd", "7use" ]

5

[ "PUB00044392", "PUB00098479", "PUB00098480" ]

[ "10673335", "24439376", "27605705" ]

[ "Molecular cloning of a novel apoptosis-related gene, human Nap1 (NCKAP1), and its possible relation to Alzheimer disease.", "The WAVE regulatory complex links diverse receptors to the actin cytoskeleton.", "Retrolinkin recruits the WAVE1 protein complex to facilitate BDNF-induced TrkB endocytosis and dendrite ...

[ 2000, 2014, 2016 ]

3

[]

0

null

[ "Eukaryota", "bird metagenome" ]

[ 6105, 1 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 5, 1, 9, 1, 11, 7, 5, 14, 38 ]

9

true

Family

Nck-associated protein 1

Nck-associated_protein-1

1

IPR019138

19,138

De-etiolated protein 1, Det1

De-etiolated_protein_1_Det1

Family

4,242

false

This entry represents Det1 family proteins [ ]. Det1 (de-etiolated-1) is an essential negative regulator of plant light responses, and it is a component of the Arabidopsis CDD complex containing DDB1 and COP10 ubiquitin E2 variant. Mammalian Det1 forms stable DDD-E2 complexes, consisting of DDB1, DDA1 (DET1, DDB1 Assoc...

[]

0

[ "PFAM", "PANTHER" ]

[ "PF09737", "PTHR13374" ]

[ "Det1", "" ]

[ 4036, 3563 ]

2

[ "REACTOME", "REACTOME" ]

[ "R-HSA-983168", "R-MMU-983168" ]

[ "REACTOME:R-HSA-983168", "REACTOME:R-MMU-983168" ]

2

[ "9bjz", "9dhd" ]

2

[ "PUB00044222", "PUB00044225", "PUB00161772" ]

[ "17452440", "12589545", "39937864" ]

[ "Mammalian DET1 regulates Cul4A activity and forms stable complexes with E2 ubiquitin-conjugating enzymes.", "The tomato dark green mutation is a novel allele of the tomato homolog of the DEETIOLATED1 gene.", "Impairment of DET1 causes neurological defects and lethality in mice and humans." ]

[ 2007, 2003, 2025 ]

3

[]

0

null

[ "Bacteria", "Eukaryota" ]

[ 9, 4233 ]

2

[ "Arabidopsis thaliana", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 5, 13, 3, 2, 3, 1, 5, 5, 32 ]

9

true

Family

De-etiolated protein 1, Det1

De-etiolated_protein_1_Det1

6

IPR019139

19,139

Leucine-rich repeat flightless-interacting protein 1/2

LRRFIP1/2

Family

8,418

false

Leucine-rich repeat flightless-interacting protein 1 (LRRFIP1) is a transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'-AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA [ ]. It may control smooth muscle cell proliferation following artery injury through PDGFA rep...

[ "GO:0006355" ]

[ "regulation of DNA-templated transcription" ]

[ "biological_process" ]

1

[ "PFAM", "PANTHER" ]

[ "PF09738", "PTHR19212" ]

[ "LRRFIP", "" ]

[ 8171, 8318 ]

2

[ "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-1839117", "R-HSA-3134973", "R-HSA-5655302" ]

[ "REACTOME:R-HSA-1839117", "REACTOME:R-HSA-3134973", "REACTOME:R-HSA-5655302" ]

3

[ "4h22" ]

1

[ "PUB00078055", "PUB00078056", "PUB00078057" ]

[ "16199883", "19265123", "15677333" ]

[ "GCF2/LRRFIP1 represses tumor necrosis factor alpha expression.", "Modulation of TLR signaling by multiple MyD88-interacting partners including leucine-rich repeat Fli-I-interacting proteins.", "Identification of the Wnt signaling activator leucine-rich repeat in Flightless interaction protein 2 by a genome-wid...

[ 2005, 2009, 2005 ]

3

[]

0

null

[ "Metazoa" ]

[ 8418 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 101, 1, 16, 23, 33 ]

6

true

Family

Leucine-rich repeat flightless-interacting protein 1/2

LRRFIP1/2

9

IPR019140

19,140

Mini-chromosome maintenance complex-binding protein

MCM_complex-bd

Family

3,568

false

This entry represents a family of proteins which are approximately 600 residues in length and contain alternating regions of conservation and low complexity. They are associated components of the mini-chromosome maintenance (MCM) complex that acts as a regulator of DNA replication. They bind to the MCM complex during l...

[]

0

[ "PFAM", "PANTHER" ]

[ "PF09739", "PTHR13489" ]

[ "MCM_bind", "" ]

[ 3562, 3473 ]

2

[]

0

[]

0

[ "PUB00055075", "PUB00055082" ]

[ "20090939", "21196493" ]

[ "The MCM-binding protein ETG1 aids sister chromatid cohesion required for postreplicative homologous recombination repair.", "MCM-BP regulates unloading of the MCM2-7 helicase in late S phase." ]

[ 2010, 2011 ]

2

[]

0

null

[ "Eukaryota" ]

[ 3568 ]

1

[ "Arabidopsis thaliana", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)", "Zea mays" ]

[ 3, 3, 1, 3, 2, 4, 7, 1, 8 ]

9

true

Family

Mini-chromosome maintenance complex-binding protein

MCM_complex-bd

7

IPR019141

19,141

Protein of unknown function DUF2045

DUF2045

Family

4,311

false

This entry represents Protein PHLOEM PROTEIN 2-LIKE A1 (PP2-like) found in plants and Uncharacterized protein KIAA0930 proteins found in animals. KIAA0930 is localised in the cytosol and not secreted from cells. Expression of KIAA0930 (C22orf9) is significantly higher in pancreatic, colorectal, gastric, and tongue canc...

[]

0

[ "PANTHER" ]

[ "PTHR21477" ]

[ "" ]

[ 4311 ]

1

[]

0

[]

0

[ "PUB00058182", "PUB00163385" ]

[ "12529520", "37477523" ]

[ "Diversity of the superfamily of phloem lectins (phloem protein 2) in angiosperms.", "The uncharacterized transcript <i>KIAA0930</i> confers a cachexic phenotype on cancer cells." ]

[ 2003, 2023 ]

2

[]

0

null

[ "Eukaryota" ]

[ 4311 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 29, 1, 1, 3, 6, 3, 25, 4, 16 ]

9

true

Family

Protein of unknown function DUF2045

DUF2045

5

IPR019142

19,142

Dymeclin

Family

4,202

false

Dymeclin (Dyggve-Melchior-Clausen syndrome protein) contains a large number of leucine and isoleucine residues and a total of 17 repeated dileucine motifs. It is characteristically about 700 residues long and present in plants and animals. Human dymeclin is necessary for correct organisation of Golgi apparatus and is i...

[]

0

[ "PANTHER" ]

[ "PTHR12895" ]

[ "" ]

[ 4202 ]

1

[]

0

[]

0

[ "PUB00044238", "PUB00075468" ]

[ "12554689", "21280149" ]

[ "Mutations in a novel gene Dymeclin (FLJ20071) are responsible for Dyggve-Melchior-Clausen syndrome.", "Dymeclin, the gene underlying Dyggve-Melchior-Clausen syndrome, encodes a protein integral to extracellular matrix and golgi organization and is associated with protein secretion pathways critical in bone devel...

[ 2003, 2011 ]

2

[]

0

null

[ "Eukaryota" ]

[ 4202 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 7, 1, 1, 1, 11, 3, 3, 10, 16 ]

9

true

Family

Dymeclin

6

IPR019144

19,144

Membralin

Family

2,999

false

Membralin is evolutionarily highly conserved, though it appears to represent a unique protein family. The protein appears to contain several transmembrane regions. In humans it is expressed in certain cancers, particularly ovarian cancers [ ]. Membralin-like gene homologues have been identified in plants including grap...

[]

0

[ "PFAM" ]

[ "PF09746" ]

[ "Membralin" ]

[ 2999 ]

1

[]

0

[]

0

[ "PUB00044354", "PUB00053399" ]

[ "16084606", "12638133" ]

[ "Identification and characterization of membralin, a novel tumor-associated gene, in ovarian carcinoma.", "Characterization and expression of the gene encoding membralin, an evolutionary conserved protein expressed in the central nervous system." ]

[ 2005, 2002 ]

2

[]

0

null

[ "Eukaryota" ]

[ 2999 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 6, 2, 4, 1, 6, 3, 3, 8, 24 ]

9

true

Family

Membralin

4

IPR019145

19,145

Mediator complex, subunit Med10

Mediator_Med10

Family

4,161

false

The Mediator complex is a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. The Mediator complex, having a compact confor...

[ "GO:0003712", "GO:0006357", "GO:0016592" ]

[ "transcription coregulator activity", "regulation of transcription by RNA polymerase II", "mediator complex" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PFAM" ]

[ "PF09748" ]

[ "Med10" ]

[ 4161 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-212436", "R-BTA-9841922", "R-DME-9841922", "R-HSA-1989781", "R-HSA-212436", "R-HSA-381340", "R-HSA-9833110", "R-HSA-9841922" ]

[ "REACTOME:R-BTA-212436", "REACTOME:R-BTA-9841922", "REACTOME:R-DME-9841922", "REACTOME:R-HSA-1989781", "REACTOME:R-HSA-212436", "REACTOME:R-HSA-381340", "REACTOME:R-HSA-9833110", "REACTOME:R-HSA-9841922" ]

8

[ "5n9j", "5oqm", "6w1s", "7emf", "7ena", "7enc", "7enj", "7lbm", "7nvr", "7ui9", "7uif", "7uig", "7uio", "8cen", "8ceo", "8gxq", "8gxs", "8t1i", "8t1l", "8t9d", "8tqw", "8trh" ]

22

[ "PUB00044353" ]

[ "9891034" ]

[ "Activator-specific requirement of yeast mediator proteins for RNA polymerase II transcriptional activation." ]

[ 1999 ]

1

[]

0

null

[ "Chryseotalea sanaruensis", "Eukaryota" ]

[ 1, 4160 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 8, 1, 1, 2, 1, 4, 1, 2, 3, 1, 1, 9 ]

12

true

Family

Mediator complex, subunit Med10

Mediator_Med10

3

IPR019147

19,147

Suppressor of white apricot, N-terminal domain

SWAP_N_domain

Domain

5,317

false

This entry represents the conserved N-terminal region of SWAP (suppressor-of-white-apricot protein) splice factor proteins. This region contains two highly conserved motifs, viz: DRY and EERY, which appear to be the sites for alternative splicing of exons 2 and 3 of the SWAP mRNA [ ]. These proteins are thus thought to...

[]

0

[ "PFAM", "SMART" ]

[ "PF09750", "SM01141" ]

[ "DRY_EERY", "DRY_EERY" ]

[ 5292, 5255 ]

2

[]

0

[]

0

[ "PUB00002852" ]

[ "8206918" ]

[ "Conservation of regulated alternative splicing and identification of functional domains in vertebrate homologs to the Drosophila splicing regulator, suppressor-of-white-apricot." ]

[ 1994 ]

1

[]

0

null

[ "Eukaryota", "bird metagenome" ]

[ 5316, 1 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 19, 5, 3, 7, 10, 6, 7, 9, 12 ]

9

true

Domain

Suppressor of white apricot, N-terminal domain

SWAP_N_domain

2

IPR019148

19,148

Nuclear protein DGCR14/ESS-2

Nuclear_protein_DGCR14_ESS-2

Family

4,321

false

This entry represents a family of proteins known variously as DiGeorge syndrome critical region 14 (DGCR14), DiGeorge syndrome protein I (DGSI), ES2 and ESS-2. In yeast the homologue is known as stress response protein Bis1. Proteins in this family consist of approximately 500 residues with alternating regions of low c...

[]

0

[ "PFAM", "PANTHER" ]

[ "PF09751", "PTHR12940" ]

[ "Es2", "" ]

[ 4303, 4191 ]

2

[]

0

[ "8c6j", "8ro2", "9esi", "9fmd" ]

4

[ "PUB00088169", "PUB00088171" ]

[ "25194163", "22365833" ]

[ "Systematic analyses of rpm-1 suppressors reveal roles for ESS-2 in mRNA splicing in Caenorhabditis elegans.", "Dynamic protein-protein interaction wiring of the human spliceosome." ]

[ 2014, 2012 ]

2

[]

0

null

[ "Eukaryota" ]

[ 4321 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Schizosaccharomyces pombe (stra...

[ 2, 1, 1, 12, 2, 3, 1, 3, 4, 1, 11 ]

11

true

Family

Nuclear protein DGCR14/ESS-2

Nuclear_protein_DGCR14_ESS-2

3

IPR019149

19,149

Alpha/beta hydrolase domain-containing protein 18

ABHD18

Family

3,659

false

This entry represents alpha/beta hydrolase domain-containing protein 18 (ABHD18). Its function is not clear.

[]

0

[ "PFAM" ]

[ "PF09752" ]

[ "ABHD18" ]

[ 3659 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Methanobacteriota", "ecological metagenomes" ]

[ 347, 3287, 18, 7 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 7, 1, 2, 3, 5, 9, 3, 4, 3 ]

9

true

Family

Alpha/beta hydrolase domain-containing protein 18

ABHD18

2

IPR019150

19,150

Vesicle transport protein, Use1

Vesicle_transport_protein_Use1

Family

4,477

false

This entry represents a family of proteins, approximately 300 residues in length, involved in vesicle transport. They have a single C-terminal transmembrane domain and a SNARE [soluble NSF (N-ethylmaleimide-sensitive fusion protein) attachment protein receptor] domain of approximately 60 residues. The SNARE domains are...

[]

0

[ "PFAM", "PANTHER" ]

[ "PF09753", "PTHR13050" ]

[ "Use1", "" ]

[ 3796, 4225 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-CEL-6811434", "R-DME-6811434", "R-DRE-6811434", "R-HSA-6811434", "R-MMU-6811434", "R-SCE-6811434", "R-SPO-6811434" ]

[ "REACTOME:R-CEL-6811434", "REACTOME:R-DME-6811434", "REACTOME:R-DRE-6811434", "REACTOME:R-HSA-6811434", "REACTOME:R-MMU-6811434", "REACTOME:R-SCE-6811434", "REACTOME:R-SPO-6811434" ]

7

[]

0

[ "PUB00045165" ]

[ "12853481" ]

[ "Use1p is a yeast SNARE protein required for retrograde traffic to the ER." ]

[ 2003 ]

1

[]

0

null

[ "Eukaryota" ]

[ 4477 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 12, 1, 1, 1, 3, 6, 1, 13, 8, 1, 1, 11 ]

12

true

Family

Vesicle transport protein, Use1

Vesicle_transport_protein_Use1

8

IPR019152

19,152

Protein of unknown function DUF2046

DUF2046

Family

2,589

false

This is the conserved N-terminal 350 residues of a family of proteins of unknown function possibly containing a coiled-coil domain.

[]

0

[ "PFAM", "PANTHER" ]

[ "PF09755", "PTHR15276" ]

[ "DUF2046", "" ]

[ 2559, 2479 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Pyrobaculum aerophilum" ]

[ 4, 2584, 1 ]

3

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 2, 3, 7, 3, 2 ]

6

true

Family

Protein of unknown function DUF2046

DUF2046

1

IPR019153

19,153

DDRGK domain containing protein

DDRGK_dom-contain

Family

2,588

false

This is a family of proteins that contain a highly conserved DDRGK motif. In humans, DDRGK domain-containing protein 1 is a substrate adapter for ufmylation, the covalent attachment of the ubiquitin-like modifier UFM1 to substrate proteins, which plays a key role in reticulophagy (also called ER-phagy) [ ]. It is also ...

[]

0

[ "PFAM", "SMART" ]

[ "PF09756", "SM01128" ]

[ "DDRGK", "DDRGK" ]

[ 2565, 2499 ]

2

[ "REACTOME", "REACTOME" ]

[ "R-HSA-8980692", "R-MMU-8980692" ]

[ "REACTOME:R-HSA-8980692", "REACTOME:R-MMU-8980692" ]

2

[ "1wi9", "8b9x", "8c0d", "8ohd", "8oj0", "8oj5", "8qfc", "9gy4" ]

8

[ "PUB00095670", "PUB00100361" ]

[ "32160526", "28263186" ]

[ "A Genome-wide ER-phagy Screen Highlights Key Roles of Mitochondrial Metabolism and ER-Resident UFMylation.", "Loss of DDRGK1 modulates SOX9 ubiquitination in spondyloepimetaphyseal dysplasia." ]

[ 2020, 2017 ]

2

[]

0

null

[ "Eukaryota", "marine sediment metagenome" ]

[ 2585, 3 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 4, 1, 1, 1, 3, 2, 2, 3, 6 ]

9

true

Family

DDRGK domain containing protein

DDRGK_dom-contain

5

IPR019154

19,154

Arb2-like domain

Arb2-like_domain

Domain

1,739

false

This entry represents the C-terminal non-catalytic domain of Clr3 (Cryptic loci regulator 3, also known as histone deacetylase clr3) ( ) from S. pombe and its orthologue HDA1 from S. cerevisiae. Structure analysis reveals that this domain is related to Arb2 domain from S. pombe (not included in this entry), which has c...

[]

0

[ "PFAM" ]

[ "PF09757" ]

[ "Arb2-like" ]

[ 1739 ]

1

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "3.5.1.98", "R-SCE-3214815", "R-SCE-3371511", "R-SCE-4551638", "R-SPO-3214815", "R-SPO-3371511", "R-SPO-4551638" ]

[ "EC:3.5.1.98", "REACTOME:R-SCE-3214815", "REACTOME:R-SCE-3371511", "REACTOME:R-SCE-4551638", "REACTOME:R-SPO-3214815", "REACTOME:R-SPO-3371511", "REACTOME:R-SPO-4551638" ]

7

[ "5ikk", "5j8j", "6z6f", "6z6h", "6z6o", "6z6p" ]

6

[ "PUB00085068", "PUB00151886", "PUB00151887" ]

[ "27105116", "27665728", "33523989" ]

[ "SHREC Silences Heterochromatin via Distinct Remodeling and Deacetylation Modules.", "Structural and histone binding ability characterization of the ARB2 domain of a histone deacetylase Hda1 from Saccharomyces cerevisiae.", "Structural basis for the regulation of nucleosome recognition and HDAC activity by hist...

[ 2016, 2016, 2021 ]

3

[]

0

null

[ "Eukaryota" ]

[ 1739 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 1, 1 ]

3

true

Domain

Arb2-like domain

Arb2-like_domain

4

IPR019156

19,156

Ataxin-10 domain

Ataxin-10_domain

Domain

3,947

false

This is the conserved C-terminal 100 residues of Ataxin-10. Ataxin-10 belongs to the family of armadillo repeat proteins and in solution it tends to form homotrimeric complexes, which associate via a tip-to-tip association in a horseshoe-shaped contact with the concave sides of the molecules facing each other. This dom...

[]

0

[ "PFAM" ]

[ "PF09759" ]

[ "Atx10homo_assoc" ]

[ 3947 ]

1

[]

0

[]

0

[ "PUB00044162" ]

[ "15201271" ]

[ "Ataxin-10, the spinocerebellar ataxia type 10 neurodegenerative disorder protein, is essential for survival of cerebellar neurons." ]

[ 2004 ]

1

[]

0

null

[ "Eukaryota" ]

[ 3947 ]

1

[ "Arabidopsis thaliana", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "...

[ 5, 3, 2, 5, 4, 1, 2, 4, 1, 1, 2 ]

11

true

Domain

Ataxin-10 domain

Ataxin-10_domain

5

IPR019159

19,159

CCDC93, coiled-coil domain

CCDC93_CC

Domain

2,898

false

This entry represents the coiled-coil domain found in CCDC93. Human CCDC93 is part of the COMMD/CCDC22/CCDC93 (CCC) complex that interacts with the multisubunit WASH complex, which is required for endosomal deposition of F-actin and cargo trafficking in conjunction with the retromer [ ]. The CCC complex controls Notch ...

[]

0

[ "PFAM" ]

[ "PF09762" ]

[ "CCDC93_CC" ]

[ 2898 ]

1

[]

0

[ "8f2u", "8p0v", "8p0w", "8p0x" ]

4

[ "PUB00077066", "PUB00088943" ]

[ "25355947", "26553930" ]

[ "COMMD1 is linked to the WASH complex and regulates endosomal trafficking of the copper transporter ATP7A.", "Endosomal sorting of Notch receptors through COMMD9-dependent pathways modulates Notch signaling." ]

[ 2015, 2015 ]

2

[]

0

null

[ "Eukaryota", "Litorilituus lipolyticus" ]

[ 2897, 1 ]

2

[ "Arabidopsis thaliana", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 7, 2, 2, 3, 5, 4 ]

6

true

Domain

CCDC93, coiled-coil domain

CCDC93_CC

2

IPR019160

19,160

Exocyst complex component Sec3, coiled-coil

Sec3_CC

Domain

5,850

false

This entry represents the C-terminal domain of Sec3 (also known as ExoC1), a component of the exocyst complex (composed of Exoc1, Exoc2, Exoc3, Exoc4, Exoc5, Exoc6, Exoc7 and Exoc8) which mediates the tethering of post-Golgi secretory vesicles to the plasma membrane and promotes the assembly of the SNARE complex for me...

[ "GO:0006887", "GO:0000145" ]

[ "exocytosis", "exocyst" ]

[ "biological_process", "cellular_component" ]

2

[ "PFAM" ]

[ "PF09763" ]

[ "Sec3_CC" ]

[ 5850 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-CEL-264876", "R-CEL-5620916", "R-DDI-264876", "R-DME-264876", "R-DME-5620916", "R-HSA-1445148", "R-HSA-264876", "R-HSA-5620916", "R-MMU-264876", "R-MMU-5620916" ]

[ "REACTOME:R-CEL-264876", "REACTOME:R-CEL-5620916", "REACTOME:R-DDI-264876", "REACTOME:R-DME-264876", "REACTOME:R-DME-5620916", "REACTOME:R-HSA-1445148", "REACTOME:R-HSA-264876", "REACTOME:R-HSA-5620916", "REACTOME:R-MMU-264876", "REACTOME:R-MMU-5620916" ]

10

[ "5yfp", "6vkl" ]

2

[ "PUB00045127", "PUB00100040", "PUB00100047", "PUB00100048" ]

[ "16181645", "28098232", "34061181", "29335562" ]

[ "The glycine transporter GLYT1 interacts with Sec3, a component of the exocyst complex.", "Crystal structure of Sec10, a subunit of the exocyst complex.", "Homology and Modular Evolution of CATCHR at the Origin of the Eukaryotic Endomembrane System.", "Cryo-EM structure of the exocyst complex." ]

[ 2005, 2017, 2021, 2018 ]

4

[]

0

null

[ "Avian orthoreovirus", "Bacillati", "Eukaryota" ]

[ 2, 7, 5841 ]

3

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 10, 1, 12, 2, 1, 4, 2, 9, 7, 1, 16 ]

11

true

Domain

Exocyst complex component Sec3, coiled-coil

Sec3_CC

4

IPR019163

19,163

THO complex, subunit 5

THO_Thoc5

Family

6,498

false

This entry represents Thoc5 which is one of the subunits of the THO complex, which additionally contains: HPR1, Thoc2, Thoc6 and Thoc7. The evolutionarily conserved multisubunit THO complex, which is recruited to actively transcribed genes is required for the efficient expression of genes that have internal tandem repe...

[]

0

[ "PFAM", "PANTHER" ]

[ "PF09766", "PTHR13375" ]

[ "FmiP_Thoc5", "" ]

[ 6128, 6259 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-DME-159236", "R-DME-72187", "R-DME-73856", "R-HSA-159236", "R-HSA-72187", "R-HSA-73856", "R-HSA-9680350", "R-MMU-159236", "R-MMU-72187", "R-MMU-73856", "R-RNO-159236", "R-RNO-72187", "R-RNO-73856" ]

[ "REACTOME:R-DME-159236", "REACTOME:R-DME-72187", "REACTOME:R-DME-73856", "REACTOME:R-HSA-159236", "REACTOME:R-HSA-72187", "REACTOME:R-HSA-73856", "REACTOME:R-HSA-9680350", "REACTOME:R-MMU-159236", "REACTOME:R-MMU-72187", "REACTOME:R-MMU-73856", "REACTOME:R-RNO-159236", "REACTOME:R-RNO-72187", ...

13

[ "7apk", "7znk", "7znl" ]

3

[ "PUB00044694", "PUB00044982", "PUB00045308", "PUB00045309" ]

[ "15133499", "10597251", "16983072", "15998806" ]

[ "Genome-wide analysis of mRNAs regulated by the THO complex in Drosophila melanogaster.", "FMIP, a novel Fms-interacting protein, affects granulocyte/macrophage differentiation.", "Genes with internal repeats require the THO complex for transcription.", "Recruitment of the human TREX complex to mRNA during sp...

[ 2004, 1999, 2006, 2005 ]

4

[]

0

null

[ "Eukaryota" ]

[ 6498 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Schizosaccharomyces pombe (stra...

[ 9, 2, 8, 1, 7, 4, 1, 3, 9, 1, 9 ]

11

true

Family

THO complex, subunit 5

THO_Thoc5

6

IPR019164

19,164

Transmembrane protein 147

TMEM147

Family

2,215

false

TMEM147 is a component of the Nicalin-NOMO protein complex, which catalyzes the proteolytic cleavage of the transmembrane domain of various proteins including the beta-amyloid precursor protein and Notch [ ]. It is a component of the multi-pass translocon (MPT) complex that mediates insertion of multi-pass membrane pro...

[]

0

[ "PFAM", "PANTHER" ]

[ "PF09767", "PTHR12869" ]

[ "DUF2053", "" ]

[ 2203, 2120 ]

2

[]

0

[ "6w6l", "7tm3", "7tut", "9c7u", "9c7v" ]

5

[ "PUB00086606", "PUB00097241", "PUB00103609" ]

[ "20538592", "32820719", "36261522" ]

[ "Transmembrane protein 147 (TMEM147) is a novel component of the Nicalin-NOMO protein complex.", "An ER translocon for multi-pass membrane protein biogenesis.", "Substrate-driven assembly of a translocon for multipass membrane proteins." ]

[ 2010, 2020, 2022 ]

3

[]

0

null

[ "Eukaryota", "bird metagenome" ]

[ 2214, 1 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 3, 1, 1, 1, 2, 6, 7, 9, 12 ]

9

true

Family

Transmembrane protein 147

TMEM147

1

IPR019165

19,165

Peptidase M76, ATP23

Peptidase_M76_ATP23

Family

4,717

false

Mitochondrial inner membrane protease ATP23 has two roles in the assembly of mitochondrial ATPase. Firstly, it acts as a protease that removes the N-terminal 10 residues of mitochondrial ATPase CF(0) subunit 6 (ATP6) at the intermembrane space side. Secondly, it is involved in the correct assembly of the membrane-embed...

[ "GO:0004222" ]

[ "metalloendopeptidase activity" ]

[ "molecular_function" ]

1

[ "PFAM", "PANTHER" ]

[ "PF09768", "PTHR21711" ]

[ "Peptidase_M76", "" ]

[ 4714, 4614 ]

2

[ "EC", "METACYC" ]

[ "3.4.24.-", "PWY-8119" ]

[ "EC:3.4.24.-", "METACYC:PWY-8119" ]

2

[]

0

[ "PUB00045070", "PUB00045278" ]

[ "17135290", "17135288" ]

[ "The metalloprotease encoded by ATP23 has a dual function in processing and assembly of subunit 6 of mitochondrial ATPase.", "Prohibitins interact genetically with Atp23, a novel processing peptidase and chaperone for the F1Fo-ATP synthase." ]

[ 2007, 2007 ]

2

[]

0

null

[ "Eukaryota", "Pseudomonadati" ]

[ 4712, 5 ]

2

[ "Arabidopsis thaliana", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "...

[ 3, 1, 1, 1, 2, 1, 6, 3, 1, 1, 4 ]

11

true

Family

Peptidase M76, ATP23

Peptidase_M76_ATP23

7

IPR019166

19,166

MICOS complex subunit MIC26/MIC27

MIC26/MIC27

Family

5,078

false

This entry includes MICOS complex subunit Mic26 from fungi and animals. Mammalian MIC26 and its paralogue, MIC27, can also be found in this entry. However, this entry does not include budding yeast Mic27.

[ "GO:0042407", "GO:0061617" ]

[ "cristae formation", "MICOS complex" ]

[ "biological_process", "cellular_component" ]

2

[ "PFAM" ]

[ "PF09769" ]

[ "ApoO" ]

[ 5078 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-114608", "R-CEL-114608", "R-HSA-114608", "R-HSA-8949613", "R-MMU-114608" ]

[ "REACTOME:R-BTA-114608", "REACTOME:R-CEL-114608", "REACTOME:R-HSA-114608", "REACTOME:R-HSA-8949613", "REACTOME:R-MMU-114608" ]

5

[]

0

[ "PUB00044151", "PUB00075633", "PUB00078047", "PUB00078048" ]

[ "16956892", "21987634", "25764979", "24743151" ]

[ "ApoO, a novel apolipoprotein, is an original glycoprotein up-regulated by diabetes in human heart.", "A mitochondrial-focused genetic interaction map reveals a scaffold-like complex required for inner membrane organization in mitochondria.", "The non-glycosylated isoform of MIC26 is a constituent of the mammal...

[ 2006, 2011, 2015, 2014 ]

4

[]

[ "IPR033181", "IPR033182" ]

0

2

0

[ "Eukaryota" ]

[ 5078 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strai...

[ 1, 4, 1, 7, 5, 1, 10, 1, 1 ]

9

true

Family

MICOS complex subunit MIC26/MIC27

MIC26/MIC27

2

IPR019167

19,167

mRNA decay factor PAT1 domain

PAT1_dom

Domain

3,938

false

This entry represents a domain found in Pat1 and its homologues. Pat1 is involved in translational repression and enhanced mRNA decay. It is part of the Lsm1-7-Pat1 complex that plays a role in activation of deadenylation-dependent decapping in the 5' to 3' pathway and in the protection of mRNA 3' ends [ ]. There are t...

[]

0

[ "PFAM" ]

[ "PF09770" ]

[ "PAT1" ]

[ 3938 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-DRE-430039", "R-HSA-430039", "R-MMU-430039", "R-RNO-430039", "R-SCE-430039", "R-SPO-430039" ]

[ "REACTOME:R-DRE-430039", "REACTOME:R-HSA-430039", "REACTOME:R-MMU-430039", "REACTOME:R-RNO-430039", "REACTOME:R-SCE-430039", "REACTOME:R-SPO-430039" ]

6

[ "2xeq", "2xer", "2xes", "4brw", "4c8q", "4n0a", "4ogp", "4ojj", "5lm5", "5lmf", "5lmg" ]

11

[ "PUB00090280", "PUB00090283" ]

[ "25035297", "22090346" ]

[ "Pat1 contributes to the RNA binding activity of the Lsm1-7-Pat1 complex.", "RNA-related nuclear functions of human Pat1b, the P-body mRNA decay factor." ]

[ 2014, 2012 ]

2

[]

0

null

[ "Eukaryota" ]

[ 3938 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 4, 5, 2, 1, 6, 5, 1, 1 ]

8

true

Domain

mRNA decay factor PAT1 domain

PAT1_dom

8

IPR019168

19,168

Nuclear envelope phosphatase-regulatory subunit 1

NEP1-R1

Family

2,199

false

Nuclear envelope phosphatase 1-regulatory subunit 1 (NEP1-R1), formerly known as TMEM188, functions in the lipin activation pathway [ ]. NEP1R1 forms a complex with the phosphatase CTDNEP1. The complex dephosphorylates and may activate phosphatidate phosphatases Lipin-1 and -2, which catalyse the conversion of phosphat...

[ "GO:0071595" ]

[ "Nem1-Spo7 phosphatase complex" ]

[ "cellular_component" ]

1

[ "PFAM", "PANTHER" ]

[ "PF09771", "PTHR20996" ]

[ "Tmemb_18A", "" ]

[ 1767, 2134 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-4419969", "R-CEL-4419969", "R-DME-4419969", "R-HSA-4419969", "R-MMU-4419969", "R-XTR-4419969" ]

[ "REACTOME:R-BTA-4419969", "REACTOME:R-CEL-4419969", "REACTOME:R-DME-4419969", "REACTOME:R-HSA-4419969", "REACTOME:R-MMU-4419969", "REACTOME:R-XTR-4419969" ]

6

[ "8ujl", "8ujm" ]

2

[ "PUB00070153" ]

[ "22134922" ]

[ "Nuclear envelope phosphatase 1-regulatory subunit 1 (formerly TMEM188) is the metazoan Spo7p ortholog and functions in the lipin activation pathway." ]

[ 2012 ]

1

[]

0

null

[ "Eukaryota" ]

[ 2199 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 1, 5, 7, 2, 5 ]

6

true

Family

Nuclear envelope phosphatase-regulatory subunit 1

NEP1-R1

3

IPR019169

19,169

Transmembrane protein 26

Transmembrane_26

Family

2,474

false

The function of this family of transmembrane proteins has not, as yet, been determined.

[]

0

[ "PFAM", "PANTHER" ]

[ "PF09772", "PTHR22168" ]

[ "Tmem26", "" ]

[ 2474, 2400 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota" ]

[ 4, 2470 ]

2

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 6, 1, 2, 4, 2 ]

6

true

Family

Transmembrane protein 26

Transmembrane_26

2

IPR019170

19,170

Meckelin

Family

2,814

false

Meckelin (also known as MKS3) is part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition [ ]. It is involved in centrosome migration to the apical cell surface during early ciliogenesis. It is required for ciliary structure and function, includi...

[ "GO:0060271", "GO:0036038" ]

[ "cilium assembly", "MKS complex" ]

[ "biological_process", "cellular_component" ]

2

[ "PFAM", "PANTHER" ]

[ "PF09773", "PTHR21274" ]

[ "Meckelin", "" ]

[ 2731, 2775 ]

2

[ "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-5620912", "R-MMU-5620912", "R-RNO-5620912" ]

[ "REACTOME:R-HSA-5620912", "REACTOME:R-MMU-5620912", "REACTOME:R-RNO-5620912" ]

3

[ "7fh1" ]

1

[ "PUB00060201", "PUB00069271", "PUB00069272", "PUB00069273", "PUB00069274", "PUB00069275" ]

[ "21725307", "17185389", "171609", "19058225", "19508969", "19515853" ]

[ "A transition zone complex regulates mammalian ciliogenesis and ciliary membrane composition.", "The Meckel-Gruber Syndrome proteins MKS1 and meckelin interact and are required for primary cilium formation.", "Synthesis of biological molecules on molecular sieves.", "MKS3/TMEM67 mutations are a major cause of...

[ 2011, 2007, 1975, 2009, 2009, 2009 ]

6

[]

0

null

[ "Eukaryota" ]

[ 2814 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 3, 2, 22, 4, 7 ]

6

true

Family

Meckelin

1

IPR019171

19,171

Intermembrane space protein MIX23

MIX23

Family

3,300

false

The intermembrane space protein MIX23 regulates or stabilises the mitochondrial protein import machinery and is specifically up-regulated under stress conditions. It is critical for the efficient import of proteins into the mitochondrial matrix, particularly if the function of the translocase of the inner membrane 23 i...

[ "GO:0005758" ]

[ "mitochondrial intermembrane space" ]

[ "cellular_component" ]

1

[ "PFAM", "PANTHER" ]

[ "PF09774", "PTHR31905" ]

[ "MIX23", "" ]

[ 3177, 3206 ]

2

[]

0

[]

0

[ "PUB00097118" ]

[ "32826315" ]

[ "The intermembrane space protein Mix23 is a novel stress-induced mitochondrial import factor." ]

[ 2020 ]

1

[]

[ "IPR016805" ]

0

1

0

[ "Eukaryota" ]

[ 3300 ]

1

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 3, 4, 4, 1, 7, 1, 1 ]

8

true

Family

Intermembrane space protein MIX23

MIX23

8

IPR019172

19,172

Osteopetrosis-associated transmembrane protein 1 precursor

Osteopetrosis-assoc_TM_1

Family

1,541

false

Osteopetrosis-associated transmembrane protein 1 (OSTM1) is required for osteoclast and melanocyte maturation and function. Mutations in OSTM1 give rise to autosomal recessive osteopetrosis, also called autosomal recessive Albers-Schonberg disease [ , ].

[]

0

[ "PFAM", "PANTHER" ]

[ "PF09777", "PTHR15644" ]

[ "OSTMP1", "" ]

[ 1541, 1509 ]

2

[ "REACTOME", "REACTOME", "REACTOME" ]

[ "R-CEL-2672351", "R-HSA-2672351", "R-MMU-2672351" ]

[ "REACTOME:R-CEL-2672351", "REACTOME:R-HSA-2672351", "REACTOME:R-MMU-2672351" ]

3

[ "7bxu", "7cq5", "7cq6", "7cq7", "7jm7", "8hvt", "9g6c", "9g6d", "9g6e" ]

9

[ "PUB00045058", "PUB00045279" ]

[ "12627228", "16813530" ]

[ "Grey-lethal mutation induces severe malignant autosomal recessive osteopetrosis in mouse and human.", "Mutations in OSTM1 (grey lethal) define a particularly severe form of autosomal recessive osteopetrosis with neural involvement." ]

[ 2003, 2006 ]

2

[]

0

null

[ "Opisthokonta" ]

[ 1541 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 2, 1, 12, 3, 4 ]

6

true

Family

Osteopetrosis-associated transmembrane protein 1 precursor

Osteopetrosis-assoc_TM_1

4

IPR019173

19,173

NADH:ubiquinone oxidoreductase, NDUFB5/SGDH subunit

NADH_UbQ_OxRdtase_B5_su

Family

1,721

false

Members of this family mediate the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone, the reaction that occurs being: NADH + ubiquinone = NAD(+) + ubiquinol [ , ].

[]

0

[ "PFAM", "PANTHER" ]

[ "PF09781", "PTHR13178" ]

[ "NDUF_B5", "" ]

[ 1717, 1682 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-611105", "R-BTA-6799198", "R-HSA-611105", "R-HSA-6799198", "R-MMU-611105", "R-MMU-6799198" ]

[ "REACTOME:R-BTA-611105", "REACTOME:R-BTA-6799198", "REACTOME:R-HSA-611105", "REACTOME:R-HSA-6799198", "REACTOME:R-MMU-611105", "REACTOME:R-MMU-6799198" ]

6

[ "5gpn", "5gup", "5lc5", "5ldw", "5ldx", "5lnk", "5o31", "5xtc", "5xtd", "5xth", "5xti", "6g2j", "6g72", "6q9b", "6qa9", "6qbx", "6qc2", "6qc3", "6qc4", "6qc5", "6qc6", "6qc7", "6qc8", "6qc9", "6qca", "6qcf", "6zka", "6zkb", "6zkc", "6zkd", "6zke", "6zkf"...

209

[ "PUB00016546", "PUB00044395" ]

[ "9425316", "16828987" ]

[ "Identification and primary structure of five human NADH-ubiquinone oxidoreductase subunits.", "Adaptive selection of mitochondrial complex I subunits during primate radiation." ]

[ 1997, 2006 ]

2

[]

0

null

[ "Bilateria" ]

[ 1721 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 2, 1, 9, 6, 7 ]

6

true

Family

NADH:ubiquinone oxidoreductase, NDUFB5/SGDH subunit

NADH_UbQ_OxRdtase_B5_su

7

IPR019174

19,174

NADH dehydrogenase 1, beta subcomplex, subunit 6

NADH_DH_b-subcmplx_su6

Family

1,523

false

The NADH dehydrogenase [ubiquinone] complex performs the first stage of electron transfer from NADH to the respiratory chain. This entry represents an accessory subunit that is not thought to be involved in catalysis [ ].

[ "GO:0006120" ]

[ "mitochondrial electron transport, NADH to ubiquinone" ]

[ "biological_process" ]

1

[ "PFAM", "PANTHER" ]

[ "PF09782", "PTHR15083" ]

[ "NDUF_B6", "" ]

[ 1523, 884 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-611105", "R-BTA-6799198", "R-HSA-611105", "R-HSA-6799198", "R-HSA-9837999", "R-MMU-611105", "R-MMU-6799198" ]

[ "REACTOME:R-BTA-611105", "REACTOME:R-BTA-6799198", "REACTOME:R-HSA-611105", "REACTOME:R-HSA-6799198", "REACTOME:R-HSA-9837999", "REACTOME:R-MMU-611105", "REACTOME:R-MMU-6799198" ]

7

[ "5gup", "5lc5", "5ldw", "5ldx", "5lnk", "5o31", "5xtc", "5xtd", "5xth", "5xti", "6g2j", "6g72", "6q9b", "6qa9", "6qbx", "6qc2", "6qc3", "6qc4", "6qc5", "6qc6", "6qc7", "6qc8", "6qc9", "6qca", "6qcf", "6zka", "6zkb", "6zkc", "6zkd", "6zke", "6zkf", "6zkg"...

208

[ "PUB00019330" ]

[ "1518044" ]

[ "Sequences of 20 subunits of NADH:ubiquinone oxidoreductase from bovine heart mitochondria. Application of a novel strategy for sequencing proteins using the polymerase chain reaction." ]

[ 1992 ]

1

[]

0

null

[ "Bilateria" ]

[ 1523 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 1, 2, 2, 3, 2 ]

6

true

Family

NADH dehydrogenase 1, beta subcomplex, subunit 6

NADH_DH_b-subcmplx_su6

8

IPR019176

19,176

Cytochrome B561-related

Cytochrome_B561-rel

Family

3,036

false

Members of this family include cytochrome B561, as well as various other putative, uncharacterised proteins.

[]

0

[ "PFAM", "PANTHER" ]

[ "PF09786", "PTHR21780" ]

[ "CytochromB561_N", "" ]

[ 2995, 2960 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Aster yellows phytoplasma", "Eukaryota" ]

[ 1, 3035 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 2, 1, 2, 4, 4, 4, 3, 7, 11 ]

9

true

Family

Cytochrome B561-related

Cytochrome_B561-rel

6

IPR019177

19,177

Golgin subfamily A member 5

Golgin_subfamily_A_member_5

Family

3,733

false

This entry represents a family of proteins involved in maintaining Golgi structure. They stimulate the formation of Golgi stacks and ribbons, and are involved in intra-Golgi retrograde transport. Two main interactions have been characterised: one with RAB1A that has been activated by GTP-binding and another with isofor...

[ "GO:0007030" ]

[ "Golgi organization" ]

[ "biological_process" ]

1

[ "PFAM", "PANTHER" ]

[ "PF09787", "PTHR13815" ]

[ "Golgin_A5", "" ]

[ 3248, 3617 ]

2

[ "REACTOME" ]

[ "R-HSA-6811438" ]

[ "REACTOME:R-HSA-6811438" ]

1

[]

0

[ "PUB00044285" ]

[ "12656988" ]

[ "Golgin-84 is a rab1 binding partner involved in Golgi structure." ]

[ 2003 ]

1

[]

0

null

[ "Eukaryota", "Phocaeicola vulgatus" ]

[ 3732, 1 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 8, 1, 1, 1, 4, 2, 4, 4, 39 ]

9

true

Family

Golgin subfamily A member 5

Golgin_subfamily_A_member_5

6

IPR019178

19,178

Phosphatidylinositol 4,5-bisphosphate 4-phosphatase

PtdIns-P2-Ptase

Family

2,660

false

Phosphatidylinositol-4,5-bisphosphate 4-phosphatases type I and type II, also known as transmembrane proteins 55B and 55A, are two metazoan enzymes that catalyse the hydrolysis of PtdIns-4,5-P(2) to phosphatidylinositol-5-phosphate (PtdIns-5-P) [ ].

[ "GO:0034597", "GO:0046856" ]

[ "phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity", "phosphatidylinositol dephosphorylation" ]

[ "molecular_function", "biological_process" ]

2

[ "PFAM", "PANTHER" ]

[ "PF09788", "PTHR21014" ]

[ "Tmemb_55A", "" ]

[ 2653, 2594 ]

2

[ "EC", "GP", "METACYC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "3.1.3.78", "GenProp1511", "PWY-6367", "PWY-6368", "R-DRE-6811555", "R-DRE-8847453", "R-HSA-6811555", "R-HSA-8847453", "R-MMU-6811555", "R-MMU-8847453", "R-RNO-6811555", "R-RNO-8847453" ]

[ "EC:3.1.3.78", "GP:GenProp1511", "METACYC:PWY-6367", "METACYC:PWY-6368", "REACTOME:R-DRE-6811555", "REACTOME:R-DRE-8847453", "REACTOME:R-HSA-6811555", "REACTOME:R-HSA-8847453", "REACTOME:R-MMU-6811555", "REACTOME:R-MMU-8847453", "REACTOME:R-RNO-6811555", "REACTOME:R-RNO-8847453" ]

12

[ "8oqh", "9qm9" ]

2

[ "PUB00045157" ]

[ "16365287" ]

[ "The identification and characterization of two phosphatidylinositol-4,5-bisphosphate 4-phosphatases." ]

[ 2005 ]

1

[]

0

null

[ "Avibacterium paragallinarum", "Metazoa" ]

[ 1, 2659 ]

2

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 4, 3, 3, 6, 6, 8 ]

6

true

Family

Phosphatidylinositol 4,5-bisphosphate 4-phosphatase

PtdIns-P2-Ptase

8

IPR019179

19,179

Coiled-coil domain-containing protein 149

CC149

Family

2,377

false

Members of this family have been annotated as being coiled-coil domain-containing protein 149, however they currently have no known function.

[]

0

[ "PFAM", "PANTHER" ]

[ "PF09789", "PTHR21682" ]

[ "CC149", "" ]

[ 2371, 2318 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Eukaryota" ]

[ 2377 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 8, 1, 4, 3, 4 ]

6

true

Family

Coiled-coil domain-containing protein 149

CC149

6

IPR019181

19,181

LSM12, anticodon-binding domain

LSM12_ABD

Domain

3,603

false

This domain of approximately 100 residues is conserved from plants to humans. It is an anticodon-binding domain of a prolyl-tRNA synthetase [ ]. It is found in Lms12 and homologues. Lsm12 is a putative RNA-binding and regulation protein that might be involved in mRNA degradation or tRNA splicing [ ]. Recently, it was d...

[]

0

[ "PFAM", "SMART" ]

[ "PF09793", "SM00995" ]

[ "AD", "AD" ]

[ 3598, 3203 ]

2

[]

0

[]

0

[ "PUB00025513", "PUB00044226", "PUB00101073" ]

[ "11399074", "15225602", "34362892" ]

[ "A succession of substrate induced conformational changes ensures the amino acid specificity of Thermus thermophilus prolyl-tRNA synthetase: comparison with histidyl-tRNA synthetase.", "Novel Sm-like proteins with long C-terminal tails and associated methyltransferases.", "Lsm12 is an NAADP receptor and a two-p...

[ 2001, 2004, 2021 ]

3

[ "IPR047574" ]

[]

1

0

1

[ "Eukaryota" ]

[ 3603 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Zea mays" ]

[ 9, 2, 3, 2, 2, 2, 4, 5, 1, 15 ]

10

true

Domain

LSM12, anticodon-binding domain

LSM12_ABD

6

IPR019182

19,182

Cytochrome b-c1 complex subunit 10, fungi

Cytochrome_b-c1_su10_fun

Family

1,530

false

This entry represents subunit 10 of the cytochrome b-c1 complex (also known as the ubiquinol-cytochrome c reductase complex or complex III). This complex is located on the inner mitochondrial membrane and it couples electron transfer from ubiquinol to cytochrome. Subunit 10 is required for stable association of the iro...

[ "GO:0006122" ]

[ "mitochondrial electron transport, ubiquinol to cytochrome c" ]

[ "biological_process" ]

1

[ "PFAM", "PANTHER" ]

[ "PF09796", "PTHR28254" ]

[ "QCR10", "" ]

[ 1529, 1401 ]

2

[ "GP", "REACTOME" ]

[ "GenProp1426", "R-SCE-9865878" ]

[ "GP:GenProp1426", "REACTOME:R-SCE-9865878" ]

2

[ "6giq", "6hu9", "6t0b", "6t15", "6ymx", "8ab6", "8ab7", "8ab8", "8ab9", "8aba", "8abb", "8abe", "8abf", "8abg", "8abh", "8abi", "8abj", "8abk", "8abl", "8abm", "8ac3", "8ac4", "8ac5", "8e7s", "8q1b", "8yhq", "8yil", "8yin", "8yio", "8zjc", "8zmt", "9bpb"...

33

[ "PUB00044452" ]

[ "8175712" ]

[ "Isolation and characterization of QCR10, the nuclear gene encoding the 8.5-kDa subunit 10 of the Saccharomyces cerevisiae cytochrome bc1 complex." ]

[ 1994 ]

1

[]

0

null

[ "Opisthokonta" ]

[ 1530 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 1, 1 ]

3

true

Family

Cytochrome b-c1 complex subunit 10, fungi

Cytochrome_b-c1_su10_fun

5

IPR019183

19,183

N-alpha-acetyltransferase 25, NatB auxiliary subunit

NAA25_NatB_aux_su

Family

4,934

false

This entry represents the N-alpha-acetyltransferase 25, NatB auxiliary subunit (NAA25) which is the non-catalytic subunit of the N-terminal acetyltransferase B complex (NatB). NAA25 forms a horseshoe-like deck to hold specifically the catalytic subunit Naa20. The NatB complex catalyses the acetylation of the amino-term...

[]

0

[ "PFAM" ]

[ "PF09797" ]

[ "NatB_MDM20" ]

[ 4934 ]

1

[ "GP" ]

[ "GenProp1491" ]

[ "GP:GenProp1491" ]

1

[ "5k04", "5k18", "6vp9", "7stx", "8bip", "8bjq", "8g0l" ]

7

[ "PUB00044391", "PUB00103804", "PUB00103805" ]

[ "12808144", "18570629", "28380339" ]

[ "Mdm20 protein functions with Nat3 protein to acetylate Tpm1 protein and regulate tropomyosin-actin interactions in budding yeast.", "Identification of the human N(alpha)-acetyltransferase complex B (hNatB): a complex important for cell-cycle progression.", "Molecular Basis of Substrate Specific Acetylation by ...

[ 2003, 2008, 2017 ]

3

[]

0

null

[ "Eukaryota" ]

[ 4934 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 6, 1, 2, 2, 2, 3, 1, 3, 4, 1, 1, 6 ]

12

true

Family

N-alpha-acetyltransferase 25, NatB auxiliary subunit

NAA25_NatB_aux_su

5

IPR019184

19,184

Uncharacterised protein family, transmembrane-17

Uncharacterised_TM-17

Family

4,866

false

This entry represents a 100 amino acid region from a family of proteins that is predicted to be a transmembrane region but its function is not known.

[]

0

[ "PFAM", "PANTHER" ]

[ "PF09799", "PTHR13531" ]

[ "Transmemb_17", "" ]

[ 4848, 4592 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-5620912", "R-HSA-5620912", "R-MMU-5620912", "R-RNO-5620912" ]

[ "REACTOME:R-BTA-5620912", "REACTOME:R-HSA-5620912", "REACTOME:R-MMU-5620912", "REACTOME:R-RNO-5620912" ]

4

[]

0

[]

0

[]

0

null

[ "Eukaryota" ]

[ 4866 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 8, 4, 9, 3, 12 ]

6

true

Family

Uncharacterised protein family, transmembrane-17

Uncharacterised_TM-17

5

IPR019185

19,185

Integral membrane protein SYS1-related

Integral_membrane_SYS1-rel

Family

5,082

false

Members of this family are integral membrane proteins involved in protein trafficking between the late Golgi and endosome. They may also serve as a receptor for ADP-ribosylation factor-related protein 1 (ARFRP1) [ ]. Sys1p is a small integral membrane protein with four predicted transmembrane domains that localises to ...

[]

0

[ "PFAM", "PANTHER" ]

[ "PF09801", "PTHR12952" ]

[ "SYS1", "" ]

[ 5028, 4908 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-6811440", "R-DDI-6811440", "R-HSA-6811440", "R-MMU-6811440", "R-SCE-6811440" ]

[ "REACTOME:R-BTA-6811440", "REACTOME:R-DDI-6811440", "REACTOME:R-HSA-6811440", "REACTOME:R-MMU-6811440", "REACTOME:R-SCE-6811440" ]

5

[]

0

[ "PUB00044507", "PUB00044508" ]

[ "15203023", "16926193" ]

[ "Membrane targeting: getting Arl to the Golgi.", "Arl1p is involved in transport of the GPI-anchored protein Gas1p from the late Golgi to the plasma membrane." ]

[ 2004, 2006 ]

2

[]

[ "IPR016973" ]

0

1

0

[ "Eukaryota", "Sphingobacterium humi" ]

[ 5081, 1 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 6, 1, 2, 2, 7, 4, 1, 2, 4, 1, 11 ]

11

true

Family

Integral membrane protein SYS1-related

Integral_membrane_SYS1-rel

5

IPR019188

19,188

snRNA-activating protein complex subunit 1

SNAPC1

Family

3,064

false

Members of this family are part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. They bind to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Furthermore, they also recruit TBP and BRF2 to the U6 s...

[]

0

[ "PFAM" ]

[ "PF09808" ]

[ "SNAPC1" ]

[ 3064 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-6807505", "R-HSA-749476", "R-HSA-76071", "R-MMU-6807505", "R-MMU-76071" ]

[ "REACTOME:R-HSA-6807505", "REACTOME:R-HSA-749476", "REACTOME:R-HSA-76071", "REACTOME:R-MMU-6807505", "REACTOME:R-MMU-76071" ]

5

[ "7xur", "7zwc", "7zwd", "7zx7", "7zx8", "7zxe", "8ity", "8iue", "8iuh", "9fso", "9fsp", "9fsq", "9fsr", "9fss", "9k3b", "9k3u", "9k3v", "9lxn" ]

18

[ "PUB00045265" ]

[ "9418884" ]

[ "The large subunit of basal transcription factor SNAPc is a Myb domain protein that interacts with Oct-1." ]

[ 1998 ]

1

[]

0

null

[ "Eukaryota" ]

[ 3064 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 6, 5, 2, 1, 2, 2, 2, 3, 13 ]

9

true

Family

snRNA-activating protein complex subunit 1

SNAPC1

8

IPR019189

19,189

Large ribosomal subunit protein mL41

Ribosomal_mL41

Family

3,833

false

This entry represents the large ribosomal subunit protein mL41, previously known as L27 in yeast and L41 in animals. mL41 is a component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the ...

[ "GO:0003735", "GO:0005762" ]

[ "structural constituent of ribosome", "mitochondrial large ribosomal subunit" ]

[ "molecular_function", "cellular_component" ]

2

[ "PFAM", "PANTHER" ]

[ "PF09809", "PTHR21338" ]

[ "MRP-L27", "" ]

[ 3755, 3662 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-CEL-5389840", "R-CEL-5419276", "R-CEL-9937383", "R-DME-5389840", "R-DME-5419276", "R-DME-9937383", "R-DRE-5389840", "R-DRE-5419276", "R-HSA-5368286", "R-HSA-5389840", "R-HSA-5419276", "R-HSA-9937383", "R-MMU-5389840", "R-MMU-5419276", "R-MMU-9937383", "R-RNO-5389840", "R-RNO-54192...

[ "REACTOME:R-CEL-5389840", "REACTOME:R-CEL-5419276", "REACTOME:R-CEL-9937383", "REACTOME:R-DME-5389840", "REACTOME:R-DME-5419276", "REACTOME:R-DME-9937383", "REACTOME:R-DRE-5389840", "REACTOME:R-DRE-5419276", "REACTOME:R-HSA-5368286", "REACTOME:R-HSA-5389840", "REACTOME:R-HSA-5419276", "REACTOM...

18

[ "3j6b", "3j7y", "3j9m", "4v1a", "5aj4", "5mrc", "5mre", "5mrf", "5ool", "5oom", "6gaw", "6gb2", "6i9r", "6nu2", "6nu3", "6vlz", "6vmi", "6xyw", "6ydp", "6ydw", "6ywe", "6yws", "6ywv", "6ywx", "6ywy", "6z1p", "6zm5", "6zm6", "6zs9", "6zsa", "6zsb", "6zsc"...

108

[ "PUB00087081", "PUB00089004", "PUB00090386", "PUB00151112", "PUB00151113" ]

[ "24675956", "25609543", "28892042", "16256947", "16024796" ]

[ "Structure of the yeast mitochondrial large ribosomal subunit.", "Organization of the mitochondrial translation machinery studied in situ by cryoelectron tomography.", "Structures of the human mitochondrial ribosome in native states of assembly.", "Mitochondrial ribosomal protein L41 mediates serum starvation...

[ 2014, 2015, 2017, 2005, 2005 ]

5

[]

0

null

[ "Eukaryota" ]

[ 3833 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 12, 1, 2, 1, 1, 2, 1, 3, 3, 1, 1, 8 ]

12

true

Family

Large ribosomal subunit protein mL41

Ribosomal_mL41

2

IPR019190

19,190

Exonuclease V

EXOV

Family

3,017

false

In Saccharomyces cerevisiae (Baker's yeast), Exo5 is a single strand DNA specific 5'-exonuclease, which is involved in mitochondrial DNA replication and recombination. It has the capacity to slide across 5' double-stranded DNA or 5'RNA sequences and resumes cutting two nucleotides downstream of the double-stranded-to-s...

[ "GO:0045145" ]

[ "single-stranded DNA 5'-3' DNA exonuclease activity" ]

[ "molecular_function" ]

1

[ "PFAM", "PANTHER" ]

[ "PF09810", "PTHR14464" ]

[ "Exo5", "" ]

[ 2993, 2953 ]

2

[]

0

[ "7lw7", "7lw8", "7lw9", "7lwa" ]

4

[ "PUB00062398", "PUB00066720" ]

[ "20086101", "3286646" ]

[ "Yeast exonuclease 5 is essential for mitochondrial genome maintenance.", "Exonuclease V from Saccharomyces cerevisiae. A 5'----3'-deoxyribonuclease that produces dinucleotides in a sequential fashion." ]

[ 2010, 1988 ]

2

[]

[ "IPR016610" ]

0

1

0

[ "Archaea", "Candidatus Manganitrophus noduliformans", "Eukaryota", "Ostreid herpesvirus 1 (isolate France)", "ecological metagenomes" ]

[ 22, 1, 2988, 1, 5 ]

5

[ "Arabidopsis thaliana", "Danio rerio", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (st...

[ 3, 4, 5, 3, 1, 4, 3, 1, 1, 9 ]

10

true

Family

Exonuclease V

EXOV

9

IPR019191

19,191

Essential protein Yae1, N-terminal

Essential_protein_Yae1_N

Domain

6,915

false

This entry represents proteins found in the N-terminal region of the essential protein Yae1. Proteins containing this domain include ORAOV1 (Oral cancer-overexpressed protein 1) and YAE1 [ ]. Their function is not clear. In Saccharomyces cerevisiae, Lto1 (ORAOV1 homologue) forms a complex with Rli1 and Yae1, which reli...

[]

0

[ "PFAM" ]

[ "PF09811" ]

[ "Yae1_N" ]

[ 6915 ]

1

[]

0

[]

0

[ "PUB00066966" ]

[ "23318452" ]

[ "The function of ORAOV1/LTO1, a gene that is overexpressed frequently in cancer: essential roles in the function and biogenesis of the ribosome." ]

[ 2013 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "Methanosarcina barkeri 3", "metagenomes" ]

[ 175, 6737, 1, 2 ]

4

[ "Arabidopsis thaliana", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "...

[ 19, 2, 2, 8, 13, 2, 9, 14, 2, 2, 23 ]

11

true

Domain

Essential protein Yae1, N-terminal

Essential_protein_Yae1_N

3

IPR019192

19,192

Large ribosomal subunit protein mL40

Ribosomal_mL40

Family

2,383

false

This entry represents the large ribosomal subunit protein mL40, previously known as L28 in yeast and L40 in mammals. Members of this family are components of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at ...

[]

0

[ "PFAM" ]

[ "PF09812" ]

[ "MRP-L28" ]

[ 2383 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-5368286", "R-HSA-5389840", "R-HSA-5419276", "R-HSA-9937383", "R-MMU-5389840", "R-MMU-5419276", "R-MMU-9937383", "R-RNO-5389840", "R-RNO-5419276", "R-RNO-9937383" ]

[ "REACTOME:R-HSA-5368286", "REACTOME:R-HSA-5389840", "REACTOME:R-HSA-5419276", "REACTOME:R-HSA-9937383", "REACTOME:R-MMU-5389840", "REACTOME:R-MMU-5419276", "REACTOME:R-MMU-9937383", "REACTOME:R-RNO-5389840", "REACTOME:R-RNO-5419276", "REACTOME:R-RNO-9937383" ]

10

[ "3j6b", "3j7y", "3j9m", "4v1a", "5aj4", "5mrc", "5mre", "5mrf", "5ool", "5oom", "6gaw", "6gb2", "6i9r", "6nu2", "6nu3", "6vlz", "6vmi", "6ydp", "6ydw", "6zm5", "6zm6", "6zs9", "6zsa", "6zsb", "6zsc", "6zsd", "6zse", "6zsg", "7a5f", "7a5g", "7a5h", "7a5i"...

91

[ "PUB00007068", "PUB00007069", "PUB00007070", "PUB00044374", "PUB00044375", "PUB00087081", "PUB00089004" ]

[ "11297922", "11290319", "11114498", "12125055", "2060626", "24675956", "25609543" ]

[ "Atomic structures at last: the ribosome in 2000.", "The ribosome in focus.", "The end of the beginning: structural studies of ribosomal proteins.", "Genomic differences between Candida glabrata and Saccharomyces cerevisiae around the MRPL28 and GCN3 loci.", "Extended N-terminal sequencing of proteins of th...

[ 2001, 2001, 2000, 2002, 1991, 2014, 2015 ]

7

[]

[ "IPR039145" ]

0

1

0

[ "Eukaryota" ]

[ 2383 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 1, 1, 2, 3, 3, 1, 1 ]

8

true

Family

Large ribosomal subunit protein mL40

Ribosomal_mL40

8

IPR019193

19,193

Ubiquitin-conjugating enzyme E2-binding protein

UBQ-conj_enz_E2-bd_prot

Family

4,355

false

This entry consists of E3 ubiquitin-protein ligases which accept ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfer it to substrates, generally promoting their degradation by the proteasome [ ].

[]

0

[ "PFAM", "PANTHER" ]

[ "PF09814", "PTHR31531" ]

[ "HECT_2", "" ]

[ 4227, 3965 ]

2

[ "EC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "2.3.2.26", "PWY-7511", "R-BTA-983168", "R-HSA-983168", "R-MMU-983168", "R-RNO-983168", "R-SCE-983168", "R-SPO-983168" ]

[ "EC:2.3.2.26", "METACYC:PWY-7511", "REACTOME:R-BTA-983168", "REACTOME:R-HSA-983168", "REACTOME:R-MMU-983168", "REACTOME:R-RNO-983168", "REACTOME:R-SCE-983168", "REACTOME:R-SPO-983168" ]

8

[]

0

[ "PUB00045280" ]

[ "15749827" ]

[ "A novel UbcH10-binding protein facilitates the ubiquitinylation of cyclin B in vitro." ]

[ 2005 ]

1

[]

0

null

[ "Eukaryota" ]

[ 4355 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 6, 1, 5, 2, 4, 3, 1, 2, 6, 1, 1, 17 ]

12

true

Family

Ubiquitin-conjugating enzyme E2-binding protein

UBQ-conj_enz_E2-bd_prot

9

IPR019194

19,194

Transcription elongation factor Eaf, N-terminal

Tscrpt_elong_fac_Eaf_N

Domain

4,883

false

This entry represents the N-terminal domain of ELL-associated factor (Eaf) proteins, which act as transcriptional transactivators of ELL and ELL2 RNA Polymerase II (Pol II) transcriptional elongation factors [ , , , ]. Eaf proteins form a stable heterodimer complex with ELL proteins to facilitate the binding of RNA pol...

[]

0

[ "PFAM" ]

[ "PF09816" ]

[ "EAF" ]

[ 4883 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-DME-112382", "R-DME-674695", "R-DME-75955", "R-GGA-112382", "R-GGA-674695", "R-GGA-75955", "R-HSA-112382", "R-HSA-674695", "R-HSA-75955", "R-MMU-112382", "R-MMU-674695", "R-MMU-75955", "R-RNO-112382", "R-RNO-674695", "R-RNO-75955" ]

[ "REACTOME:R-DME-112382", "REACTOME:R-DME-674695", "REACTOME:R-DME-75955", "REACTOME:R-GGA-112382", "REACTOME:R-GGA-674695", "REACTOME:R-GGA-75955", "REACTOME:R-HSA-112382", "REACTOME:R-HSA-674695", "REACTOME:R-HSA-75955", "REACTOME:R-MMU-112382", "REACTOME:R-MMU-674695", "REACTOME:R-MMU-75955"...

15

[ "7okx", "7oky" ]

2

[ "PUB00044239", "PUB00044240", "PUB00044241", "PUB00044244" ]

[ "11418481", "12686606", "16006523", "17150956" ]

[ "EAF1, a novel ELL-associated factor that is delocalized by expression of the MLL-ELL fusion protein.", "ELL and EAF1 are Cajal body components that are disrupted in MLL-ELL leukemia.", "ELL-associated factors 1 and 2 are positive regulators of RNA polymerase II elongation factor ELL.", "Identification and Ch...

[ 2001, 2003, 2005, 2007 ]

4

[]

0

null

[ "Eukaryota" ]

[ 4883 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Schizosaccharomyces pombe (stra...

[ 7, 1, 2, 1, 5, 3, 1, 2, 7, 1, 10 ]

11

true

Domain

Transcription elongation factor Eaf, N-terminal

Tscrpt_elong_fac_Eaf_N

1

IPR019195

19,195

ABC transporter, ATPase, putative

ABC_ATPase_put

Family

2,932

false

This entry consists of various predicted ABC transporter class ATPases. ABC transporters belong to the ATP-Binding Cassette (ABC) superfamily, which uses the hydrolysis of ATP to energise diverse biological systems. ABC transporters minimally consist of two conserved regions: a highly conserved ATP binding cassette (AB...

[]

0

[ "PANTHER" ]

[ "PTHR38149" ]

[ "" ]

[ 2932 ]

1

[]

0

[ "4yix", "4yiy", "4yj1", "5d6a" ]

4

[ "PUB00004290", "PUB00014769", "PUB00017894", "PUB00017895", "PUB00017896", "PUB00017897", "PUB00017898", "PUB00017899", "PUB00025109", "PUB00026406", "PUB00043654" ]

[ "9872322", "9873074", "11421269", "1282354", "9640644", "11988180", "11470432", "11402022", "11080142", "11532960", "11421270" ]

[ "Crystal structure of the ATP-binding subunit of an ABC transporter.", "Getting in or out: early segregation between importers and exporters in the evolution of ATP-binding cassette (ABC) transporters.", "ABC transporters: physiology, structure and mechanism--an overview.", "ABC transporters: from microorgani...

[ 1998, 1999, 2001, 1992, 1998, 2002, 2001, 2001, 2000, 2001, 2001 ]

11

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 89, 2181, 633, 29 ]

4

[]

0

true

Family

ABC transporter, ATPase, putative

ABC_ATPase_put

5

IPR019197

19,197

Biotin-protein ligase, N-terminal

Biotin-prot_ligase_N

Domain

3,563

false

The function of this structural domain is unknown. It is found to the N terminus of the biotin protein ligase catalytic domain [ ]. Biotin protein ligase carries out the post-translational modification of specific proteins by the attachment of biotin. It acts on various carboxylases such as acetyl-CoA-carboxylase, pyru...

[]

0

[ "PFAM" ]

[ "PF09825" ]

[ "BPL_N" ]

[ 3563 ]

1

[ "REACTOME", "REACTOME" ]

[ "R-SCE-196780", "R-SPO-196780" ]

[ "REACTOME:R-SCE-196780", "REACTOME:R-SPO-196780" ]

2

[]

0

[ "PUB00045333" ]

[ "18809372" ]

[ "Biotin protein ligase from Candida albicans: expression, purification and development of a novel assay." ]

[ 2008 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "ecological metagenomes", "uncultured Caudovirales phage" ]

[ 21, 946, 2569, 16, 11 ]

5

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 1, 1 ]

3

true

Domain

Biotin-protein ligase, N-terminal

Biotin-prot_ligase_N

5

IPR019198

19,198

Beta-propeller domain-containing family

Beta_propeller_containing

Family

2,540

false

This entry consists of predicted secreted proteins containing a C-terminal β-propeller domain distantly related to WD-40 repeats.

[]

0

[ "PFAM" ]

[ "PF09826" ]

[ "Beta_propel" ]

[ 2540 ]

1

[]

0

[]

0

[]

0

[]

[ "IPR014441" ]

0

1

0

[ "Archaea", "Bacteria", "Eukaryota", "metagenomes" ]

[ 275, 2045, 161, 59 ]

4

[]

0

true

Family

Beta-propeller domain-containing family

Beta_propeller_containing

3

IPR019199

19,199

Virulence-associated protein D / CRISPR associated protein Cas2

Virulence_VapD/CRISPR_Cas2

Family

9,500

false

This entry represents members of the family of Cas2, one of the first four protein families found to be associated with prokaryotic genomes containing multiple CRISPR elements. CRISPR systems protect against invasive nucleic acid sequences, including phage. Cas2 proteins have been characterised as either endoribonuclea...

[]

0

[ "PFAM" ]

[ "PF09827" ]

[ "CRISPR_Cas2" ]

[ 9500 ]

1

[]

0

[ "1zpw", "2i0x", "2i8e", "2ivy", "3exc", "3oq2", "3ui3", "4es1", "4es2", "4es3", "4qr0", "4qr1", "4qr2", "4tno", "5g4d", "5h1o", "5h1p", "5xvn", "5xvo", "5xvp", "5zyf", "6jhz", "6k2e", "6qxf", "6qxt", "6qy3", "7cr6", "7cr8", "7ei1", "7f84", "7kft", "7kfu"...

44

[ "PUB00010080", "PUB00020781", "PUB00043286", "PUB00043287", "PUB00043288", "PUB00047685", "PUB00060621", "PUB00071890", "PUB00074066", "PUB00094353", "PUB00094354", "PUB00094356" ]

[ "1398971", "16292354", "17442114", "17379808", "16545108", "18482976", "21699496", "24459147", "22942283", "30905284", "24793649", "22241770" ]

[ "Molecular characterization of a genomic region associated with virulence in Dichelobacter nodosus.", "A guild of 45 CRISPR-associated (Cas) protein families and multiple CRISPR/Cas subtypes exist in prokaryotic genomes.", "Evolutionary conservation of sequence and secondary structures in CRISPR repeats.", "C...

[ 1992, 2005, 2007, 2007, 2006, 2008, 2011, 2014, 2012, 2019, 2014, 2012 ]

12

[]

[ "IPR016368", "IPR021127" ]

0

2

0

[ "Archaea", "Bacteria", "Caudoviricetes", "Eukaryota", "unclassified sequences" ]

[ 630, 8708, 13, 13, 136 ]

5

[]

0

true

Family

Virulence-associated protein D / CRISPR associated protein Cas2

Virulence_VapD/CRISPR_Cas2

5

IPR019201

19,201

Protein of unknown function DUF2065

DUF2065

Family

4,745

false

This entry represents a protein found in various prokaryotic proteins, and has no known function.

[]

0

[ "PFAM", "PANTHER" ]

[ "PF09838", "PTHR38602" ]

[ "DUF2065", "" ]

[ 4745, 3856 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 4647, 2, 96 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Protein of unknown function DUF2065

DUF2065

4

IPR019202

19,202

Protein of unknown function DUF2067

DUF2067

Family

169

false

This entry represents Uncharacterized protein Mevan_1275 and Uncharacterized protein MJ0388 found in archaea.

[]

0

[ "PFAM" ]

[ "PF09840" ]

[ "DUF2067" ]

[ 169 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea" ]

[ 169 ]

1

[]

0

true

Family

Protein of unknown function DUF2067

DUF2067

7

IPR019205

19,205

Protein of unknown function DUF2080, transposon-encoded

DUF2080_transposon-encoded

Family

464

false

This entry represents Uncharacterized protein MJ0362 and related uncharacterised prokaryotic proteins. Some members are annotated as putative Transposon-encoded protein.

[]

0

[ "NCBIFAM", "PFAM" ]

[ "NF033496", "PF09853" ]

[ "DUF2080_fam_acc", "DUF2080" ]

[ 436, 337 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Methanoculleus virus Blf4", "metagenomes" ]

[ 386, 51, 1, 26 ]

4

[]

0

true

Family

Protein of unknown function DUF2080, transposon-encoded

DUF2080_transposon-encoded

3

IPR019206

19,206

Protein of unknown function DUF2085, transmembrane

DUF2085_TM

Family

1,017

false

This entry includes Uncharacterized protein MTH_518 and Uncharacterized protein MJ1492 from prokaryotes. It contains a transmebrane helical fold.

[]

0

[ "PFAM" ]

[ "PF09858" ]

[ "DUF2085" ]

[ 1017 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Siphoviridae sp. ctDtx1", "ecological metagenomes" ]

[ 168, 821, 1, 27 ]

4

[]

0

true

Family

Protein of unknown function DUF2085, transmembrane

DUF2085_TM

9

IPR019207

19,207

Protein of unknown function DUF2092, periplasmic

DUF2092

Family

1,553

false

This entry represents various hypothetical prokaryotic proteins of unknown function.

[]

0

[ "PFAM", "PIRSF" ]

[ "PF09865", "PIRSF012443" ]

[ "DUF2092", "UCP012443" ]

[ 1553, 350 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Gigaspora rosea", "Stenosarchaea group", "ecological metagenomes" ]

[ 1510, 1, 21, 21 ]

4

[]

0

true

Family

Protein of unknown function DUF2092, periplasmic

DUF2092

6

IPR019208

19,208

Protein of unknown function DUF2097

DUF2097

Family

112

false

This domain, found in various hypothetical prokaryotic proteins, has no known function.

[]

0

[ "PFAM", "PIRSF" ]

[ "PF09870", "PIRSF012755" ]

[ "DUF2097", "UCP012755" ]

[ 112, 8 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Methanomada group", "bioreactor metagenome" ]

[ 110, 2 ]

2

[]

0

true

Family

Protein of unknown function DUF2097

DUF2097

1

IPR019209

19,209

Protein of unknown function DUF2098

DUF2098

Family

242

false

This entry represents Uncharacterized protein MJ0157 and other uncharacterised proteins from archaea.

[]

0

[ "PFAM" ]

[ "PF09871" ]

[ "DUF2098" ]

[ 242 ]

1

[]

0

[ "8s7v", "8s7x", "9h1l" ]

3

[]

0

[]

[ "IPR017099" ]

0

1

0

[ "Archaea", "ecological metagenomes" ]

[ 236, 6 ]

2

[]

0

true

Family

Protein of unknown function DUF2098

DUF2098

8

IPR019211

19,211

Energy-converting hydrogenase subunit EhaL

EhaL

Family

78

false

This entry represents the Energy-converting hydrogenase subunit EhaL from Methanobacteria and Methanococci, including Methanocaldococcus jannaschii. [NiFe] hydrogenases function in H2 metabolism in a variety of microorganisms, enabling them to use H2 as a source of reducing equivalent under aerobic and anaerobic condit...

[]

0

[ "PFAM" ]

[ "PF09877" ]

[ "EhaL" ]

[ 78 ]

1

[]

0

[]

0

[ "PUB00014600", "PUB00035516", "PUB00035517", "PUB00035518", "PUB00096941" ]

[ "10491142", "15168611", "16645307", "15119826", "22872868" ]

[ "Methanobacterium thermoautotrophicum encodes two multisubunit membrane-bound [NiFe] hydrogenases. Transcription of the operons and sequence analysis of the deduced proteins.", "Energy-converting [NiFe] hydrogenases from archaea and extremophiles: ancestors of complex I.", "Energy-converting [NiFe] hydrogenases...

[ 1999, 2004, 2005, 2004, 2012 ]

5

[]

[ "IPR011305" ]

0

1

0

[ "Methanomada group", "bioreactor metagenome" ]

[ 77, 1 ]

2

[]

0

true

Family

Energy-converting hydrogenase subunit EhaL

EhaL

6

IPR019212

19,212

EhaG-like

Family

125

false

This entry represents a group of archaeal proteins, including membrane proteins that are predicted to be the EhaG transmembrane subunits of multi-subunit membrane-bound [NiFe]-hydrogenase Eha complexes [ , ]. This group was previously known as DUF2105.

[]

0

[ "PFAM" ]

[ "PF09878" ]

[ "EhaG" ]

[ 125 ]

1

[]

0

[]

0

[ "PUB00096941", "PUB00161043" ]

[ "22872868", "19495416" ]

[ "Essential anaplerotic role for the energy-converting hydrogenase Eha in hydrogenotrophic methanogenesis.", "Genomic characterization of methanomicrobiales reveals three classes of methanogens." ]

[ 2012, 2009 ]

2

[]

[ "IPR011311" ]

0

1

0

[ "Methanobacteriota", "ecological metagenomes" ]

[ 122, 3 ]

2

[]

0

true

Family

EhaG-like

3

IPR019213

19,213

EhaD-like

Family

123

false

This entry represents a group of archaeal proteins, including small membrane proteins that are predicted to be EhaD transmembrane subunits of multisubunit membrane-bound [NiFe]-hydrogenase Eha complexes [ , ]. This group was previously known as DUF2108.

[]

0

[ "PFAM" ]

[ "PF09881" ]

[ "EhaD" ]

[ 123 ]

1

[]

0

[]

0

[ "PUB00096941", "PUB00161043" ]

[ "22872868", "19495416" ]

[ "Essential anaplerotic role for the energy-converting hydrogenase Eha in hydrogenotrophic methanogenesis.", "Genomic characterization of methanomicrobiales reveals three classes of methanogens." ]

[ 2012, 2009 ]

2

[]

[ "IPR011308" ]

0

1

0

[ "Methanobacteriota", "ecological metagenomes" ]

[ 120, 3 ]

2

[]

0

true

Family

EhaD-like

8

IPR019214

19,214

EhaC-like

Family

203

false

This entry represents a group of archaeal proteins, including small membrane proteins that are predicted to be EhaC transmembrane subunits of multisubunit membrane-bound [NiFe]-hydrogenase Eha complexes [ , ]. This group was previously known as DUF2109.

[]

0

[ "PFAM" ]

[ "PF09882" ]

[ "EhaC" ]

[ 203 ]

1

[]

0

[]

0

[ "PUB00096941", "PUB00161043" ]

[ "22872868", "19495416" ]

[ "Essential anaplerotic role for the energy-converting hydrogenase Eha in hydrogenotrophic methanogenesis.", "Genomic characterization of methanomicrobiales reveals three classes of methanogens." ]

[ 2012, 2009 ]

2

[]

[ "IPR011316" ]

0

1

0

[ "Methanobacteriota", "ecological metagenomes" ]

[ 199, 4 ]

2

[]

0

true

Family

EhaC-like

9