LiteFold/InterPro · Datasets at Hugging Face

IPR019215

19,215

Protein of unknown function DUF2115

DUF2115

Family

354

false

This entry represents various hypothetical archaeal proteins, has no known function.

[]

0

[ "HAMAP", "PFAM", "PIRSF" ]

[ "MF_00763", "PF09888", "PIRSF004959" ]

[ "UPF0305", "DUF2115", "UCP004959" ]

[ 325, 354, 43 ]

3

[]

0

[]

0

[]

0

[]

0

null

[ "Bacillota", "Methanobacteriota", "ecological metagenomes" ]

[ 13, 333, 8 ]

3

[]

0

true

Family

Protein of unknown function DUF2115

DUF2115

3

IPR019216

19,216

Protein of unknown function DUF2116, treble clef zinc finger

DUF2116_treble_clef

Family

188

false

This entry contains various hypothetical prokaryotic proteins whose functions are unknown. They contain a conserved treble clef motif in the N-terminal part and a predicted transmembrane segment in the C-terminal part.

[]

0

[ "PFAM", "PIRSF" ]

[ "PF09889", "PIRSF004990" ]

[ "DUF2116", "UCP004990" ]

[ 188, 96 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria", "ecological metagenomes", "unclassified Caudoviricetes" ]

[ 133, 42, 11, 2 ]

4

[]

0

true

Family

Protein of unknown function DUF2116, treble clef zinc finger

DUF2116_treble_clef

3

IPR019217

19,217

Protein of unknown function DUF2118

DUF2118

Family

135

false

This entry represents a family of hypothetical proteins of unknown function.

[]

0

[ "PFAM", "PIRSF" ]

[ "PF09891", "PIRSF019115" ]

[ "DUF2118", "UCP019115" ]

[ 135, 45 ]

2

[]

0

[ "3d4r" ]

1

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota" ]

[ 125, 8, 2 ]

3

[]

0

true

Family

Protein of unknown function DUF2118

DUF2118

8

IPR019219

19,219

Protein of unknown function DUF2130

DUF2130

Family

2,787

false

This entry, found in various hypothetical bacterial proteins, has no known function.

[]

0

[ "PFAM", "PIRSF" ]

[ "PF09903", "PIRSF005850" ]

[ "DUF2130", "UCP005850" ]

[ 2787, 1273 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "metagenomes", "uncultured Caudovirales phage" ]

[ 9, 2675, 18, 84, 1 ]

5

[]

0

true

Family

Protein of unknown function DUF2130

DUF2130

9

IPR019220

19,220

Domain of unknown function DUF2135

DUF2135

Domain

1,800

false

This entry, found in various hypothetical prokaryotic proteins, has no known function.

[]

0

[ "PFAM" ]

[ "PF09906" ]

[ "DUF2135" ]

[ 1800 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "ecological metagenomes" ]

[ 1668, 129, 3 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Domain

Domain of unknown function DUF2135

DUF2135

4

IPR019224

19,224

Domain of unknown function DUF2148

DUF2148

Domain

758

false

This domain, found in various hypothetical bacterial and archaeal proteins containing a ferredoxin domain, has no known function.

[]

0

[ "PFAM" ]

[ "PF09918" ]

[ "DUF2148" ]

[ 758 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria", "unclassified sequences" ]

[ 181, 536, 41 ]

3

[]

0

true

Domain

Domain of unknown function DUF2148

DUF2148

3

IPR019226

19,226

Protein of unknown function DUF2158

DUF2158

Family

1,821

false

This entry represents a family of predominantly prokaryotic proteins with no known function.

[]

0

[ "PFAM" ]

[ "PF09926" ]

[ "DUF2158" ]

[ 1821 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Caudoviricetes", "Oryza sativa subsp. indica", "metagenomes" ]

[ 1769, 37, 1, 14 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Protein of unknown function DUF2158

DUF2158

2

IPR019230

19,230

tRNA (guanine-N(1)-)-methyltransferase, C-terminal

RNA_MeTrfase_C_dom

Domain

721

false

This domain, found in various hypothetical prokaryotic proteins, has no known function. It is also found at the C-terminal of a few prokaryotic tRNA (guanine-N(1)-)-methyltransferases. It has a Rossmanoid fold, with a deep trefoil knot in its C-terminal region [ ]. Proteins of this family are members of the SPOUT (SpoU...

[]

0

[ "PFAM", "CDD" ]

[ "PF09936", "cd18085" ]

[ "Methyltrn_RNA_4", "TM1570-like" ]

[ 721, 643 ]

2

[]

0

[ "3dcm", "8b1n", "8ri0" ]

3

[ "PUB00051341" ]

[ "18831037" ]

[ "Crystal structure of Thermotoga maritima SPOUT superfamily RNA methyltransferase Tm1570 in complex with S-adenosyl-L-methionine." ]

[ 2009 ]

1

[]

0

null

[ "Bacteria", "Ecdysozoa", "metagenomes" ]

[ 691, 2, 28 ]

3

[]

0

true

Domain

tRNA (guanine-N(1)-)-methyltransferase, C-terminal

RNA_MeTrfase_C_dom

7

IPR019231

19,231

Protein of unknown function DUF2170

DUF2170

Family

2,243

false

This entry represents a group of proteins from Proteobacteria, including Uncharacterized protein YjfI from Escherichia coli. Its function is unknown.

[]

0

[ "PFAM" ]

[ "PF09938" ]

[ "DUF2170" ]

[ 2243 ]

1

[]

0

[ "8q8o" ]

1

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 2223, 2, 18 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Protein of unknown function DUF2170

DUF2170

7

IPR019236

19,236

Phosphatidate phosphatase APP1, catalytic domain

APP1_cat

Domain

8,838

false

This entry represents the catalytic domain of Phosphatidate phosphatase APP1 from yeast [ , ]. This domain has a weak sequence similarity to the haloacid dehalogenase-like domain [ ]. APP1 catalyses the dephosphorylation of phosphatidate to yield diacylglycerol and may play a role in vesicular trafficking through its p...

[ "GO:0008195" ]

[ "phosphatidate phosphatase activity" ]

[ "molecular_function" ]

1

[ "PFAM" ]

[ "PF09949" ]

[ "APP1_cat" ]

[ 8838 ]

1

[]

0

[]

0

[ "PUB00071676", "PUB00098278" ]

[ "23071111", "23335564" ]

[ "The Saccharomyces cerevisiae actin patch protein App1p is a phosphatidate phosphatase enzyme.", "Characterization of the yeast actin patch protein App1p phosphatidate phosphatase." ]

[ 2012, 2013 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 4477, 4333, 28 ]

3

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 2, 1, 1 ]

3

true

Domain

Phosphatidate phosphatase APP1, catalytic domain

APP1_cat

7

IPR019238

19,238

Transcriptional regulator, AbiEi 2 antitoxin, Type IV TA system

AbiEi_2

Family

1,246

false

AbiEi_2 is the cognate antitoxin of the type IV toxin-antitoxin 'innate immunity' bacterial abortive infection (Abi) system that protects bacteria from the spread of a phage infection. The Abi system is activated upon infection with phage to abort the cell thus preventing the spread of phage through viral replication. ...

[]

0

[ "PFAM" ]

[ "PF09952" ]

[ "AbiEi_2" ]

[ 1246 ]

1

[]

0

[]

0

[ "PUB00075538" ]

[ "24465005" ]

[ "A widespread bacteriophage abortive infection system functions through a Type IV toxin-antitoxin mechanism." ]

[ 2014 ]

1

[]

[ "IPR016600" ]

0

1

0

[ "Archaea", "Bacteria", "unclassified sequences" ]

[ 2, 1202, 42 ]

3

[]

0

true

Family

Transcriptional regulator, AbiEi 2 antitoxin, Type IV TA system

AbiEi_2

4

IPR019239

19,239

Bacterial antitoxin of type II TA system, VapB

VapB_antitoxin

Family

4,906

false

VapB is the antitoxin of a bacterial toxin-antitoxin gene pair. The cognate toxin is VapC ( ). The family contains several related antitoxins from Cyanobacteria and Actinobacterial families. Antitoxins of this class carry an N-terminal ribbon-helix-helix domain, RHH, that is highly conserved across all type II bacteria...

[]

0

[ "PFAM" ]

[ "PF09957" ]

[ "VapB_antitoxin" ]

[ 4906 ]

1

[]

0

[ "4chg", "6a7v" ]

2

[ "PUB00056596", "PUB00067485" ]

[ "15718296", "20011113" ]

[ "Toxin-antitoxin loci are highly abundant in free-living but lost from host-associated prokaryotes.", "Comprehensive functional analysis of Mycobacterium tuberculosis toxin-antitoxin systems: implications for pathogenesis, stress responses, and evolution." ]

[ 2005, 2009 ]

2

[]

0

null

[ "Bacteria", "Methanomicrobiales", "Opisthokonta", "unclassified sequences" ]

[ 4797, 3, 5, 101 ]

4

[]

0

true

Family

Bacterial antitoxin of type II TA system, VapB

VapB_antitoxin

9

IPR019240

19,240

Protein of unknown function DUF2196

DUF2196

Family

3,794

false

A pair of adjacent genes, ablAB (acetyl-beta-lysine biosynthesis) encodes lysine 2,3-aminomutase and beta-lysine acetyltransferase in methanogenic archaea. Homologous pairs, possibly with identical function, occur in a wide range of species, including Bacillus subtilis. This model describes a conserved hypothetical pro...

[]

0

[ "PFAM", "PANTHER", "NCBIFAM" ]

[ "PF09962", "PTHR40069", "TIGR03833" ]

[ "DUF2196", "", "" ]

[ 3793, 3625, 3610 ]

3

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "ecological metagenomes" ]

[ 234, 2664, 845, 51 ]

4

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)" ]

[ 1 ]

1

true

Family

Protein of unknown function DUF2196

DUF2196

8

IPR019241

19,241

Protein of unknown function DUF2197

DUF2197

Family

1,292

false

This family represents various hypothetical bacterial proteins with no known function.

[]

0

[ "PFAM" ]

[ "PF09963" ]

[ "DUF2197" ]

[ 1292 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Methanobacterium spitsbergense", "hydrocarbon metagenome" ]

[ 1290, 1, 1 ]

3

[]

0

true

Family

Protein of unknown function DUF2197

DUF2197

6

IPR019243

19,243

Domain of unknown function DUF2202

DUF2202

Domain

1,309

false

This domain is found in Uncharacterized protein MJ0754 from Methanocaldococcus jannaschii and similar proteins from bacteria and archaea. MJ0754 adopts a dimeric assembly, with each monomer consisting of six α-helices [ ]. It is a member of a broad superfamily of ferritin-like diiron-carboxylate proteins whose function...

[]

0

[ "PFAM", "CDD" ]

[ "PF09968", "cd01048" ]

[ "DUF2202", "Ferritin_like_AB2" ]

[ 994, 1209 ]

2

[]

0

[ "3q4n", "3q4o", "3q4q", "3q4r" ]

4

[ "PUB00100681" ]

[ "21604308" ]

[ "Structural insights into the metal binding properties of hypothetical protein MJ0754 from Methanococcus jannaschii." ]

[ 2011 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "ecological metagenomes" ]

[ 118, 1124, 4, 63 ]

4

[]

0

true

Domain

Domain of unknown function DUF2202

DUF2202

9

IPR019247

19,247

Histidine kinase BarA, N-terminal

Histidine_kinase_BarA_N

Domain

4,540

false

This entry is found at the N terminus of various BarA-like signal transduction histidine kinases. These proteins are involved in the regulation of carbon metabolism via the csrA/csrB regulatory system [ ]. The role of this domain has not, as yet, been established.

[]

0

[ "PFAM" ]

[ "PF09984" ]

[ "sCache_4" ]

[ 4540 ]

1

[ "EC" ]

[ "2.7.13.3" ]

[ "EC:2.7.13.3" ]

1

[ "5o7j" ]

1

[ "PUB00013564" ]

[ "12533459" ]

[ "The Escherichia coli BarA-UvrY two-component system is needed for efficient switching between glycolytic and gluconeogenic carbon sources." ]

[ 2003 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 4506, 4, 30 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Domain

Histidine kinase BarA, N-terminal

Histidine_kinase_BarA_N

9

IPR019248

19,248

Glucodextranase-like, C-terminal

Glucodextran_C

Domain

975

false

This entry represents the C-terminal domain of glucodextranase-like proteins found in various prokaryotic membrane-anchored proteins. It shows homology to the carbohydrate-binding unit of some glycosidases [ ].

[]

0

[ "PFAM" ]

[ "PF09985" ]

[ "Glucodextran_C" ]

[ 975 ]

1

[]

0

[ "1ug9", "1ulv" ]

2

[ "PUB00031762" ]

[ "14660574" ]

[ "Structural insights into substrate specificity and function of glucodextranase." ]

[ 2004 ]

1

[ "IPR010502" ]

[]

1

0

1

[ "Archaea", "Bacteria", "ecological metagenomes" ]

[ 284, 686, 5 ]

3

[]

0

true

Domain

Glucodextranase-like, C-terminal

Glucodextran_C

2

IPR019249

19,249

Protein of unknown function DUF2226

DUF2226

Family

126

false

This entry represents Uncharacterized protein AF_1501 and Uncharacterized protein MJ0164.

[]

0

[ "PFAM" ]

[ "PF09987" ]

[ "DUF2226" ]

[ 126 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Pseudomonadati" ]

[ 121, 5 ]

2

[]

0

true

Family

Protein of unknown function DUF2226

DUF2226

9

IPR019250

19,250

Protein of unknown function DUF2227, metal-binding

DUF2227_metal-bd

Family

761

false

This entry represents a family of hypothetical bacterial proteins that may possess metal binding properties; however, their exact function has not yet been determined.

[]

0

[ "PFAM", "PANTHER" ]

[ "PF09988", "PTHR39085" ]

[ "DUF2227", "" ]

[ 761, 759 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Methanosarcinales", "Paulinella", "metagenomes" ]

[ 727, 28, 4, 2 ]

4

[]

0

true

Family

Protein of unknown function DUF2227, metal-binding

DUF2227_metal-bd

2

IPR019251

19,251

Domain of unknown function DUF2231, transmembrane

DUF2231_TM

Domain

10,414

false

This domain, found in various hypothetical bacterial proteins, has no known function.

[]

0

[ "PFAM" ]

[ "PF09990" ]

[ "DUF2231" ]

[ 10414 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Candidatus Methanoperedens nitratireducens", "Eukaryota", "metagenomes" ]

[ 9891, 1, 342, 180 ]

4

[]

0

true

Domain

Domain of unknown function DUF2231, transmembrane

DUF2231_TM

9

IPR019253

19,253

Protein of unknown function DUF2244, transmembrane

DUF2244_TM

Family

3,493

false

This entry consists of various bacterial putative membrane proteins with no known function.

[]

0

[ "PFAM" ]

[ "PF10003" ]

[ "DUF2244" ]

[ 3493 ]

1

[]

0

[]

0

[]

0

[]

[ "IPR016990" ]

0

1

0

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 3450, 5, 38 ]

3

[]

0

true

Family

Protein of unknown function DUF2244, transmembrane

DUF2244_TM

3

IPR019254

19,254

Protein of unknown function DUF2250

DUF2250

Family

233

false

Members of this family of hypothetical bacterial and archaeal proteins have no known function.

[]

0

[ "PFAM" ]

[ "PF10007" ]

[ "DUF2250" ]

[ 233 ]

1

[]

0

[]

0

[]

0

[]

[ "IPR017139" ]

0

1

0

[ "Archaea", "Bacteria", "Geodia barretti", "marine sediment metagenome" ]

[ 177, 54, 1, 1 ]

4

[]

0

true

Family

Protein of unknown function DUF2250

DUF2250

1

IPR019257

19,257

Histidine-specific methyltransferase, SAM-dependent methyltransferase domain

MTase_SAM-like

Domain

11,368

false

This entry represents a domain with homology to SAM-dependent methyltransferase domain in 4-dimethylallyltryptophan N-methyltransferase (EasF), Histidine N-alpha-methyltransferase and related proteins. The mycobacterial members of this family are expressed from part of the ergothioneine biosynthetic gene cluster. EGTD ...

[]

0

[ "PFAM" ]

[ "PF10017" ]

[ "Methyltransf_33" ]

[ 11368 ]

1

[ "EC" ]

[ "2.1.1" ]

[ "EC:2.1.1" ]

1

[ "4pim", "4pin", "4pio", "4pip", "4uy5", "4uy6", "4uy7", "6fnq", "6fnr", "6fns", "6fnt", "7scf", "7sew", "7sex", "7sey", "7sf4", "7sf5" ]

17

[ "PUB00060032" ]

[ "20420449" ]

[ "In vitro reconstitution of Mycobacterial ergothioneine biosynthesis." ]

[ 2010 ]

1

[]

[ "IPR017805" ]

0

1

0

[ "Archaea", "Bacteria", "Eukaryota", "metagenomes" ]

[ 101, 8057, 3100, 110 ]

4

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 2, 1 ]

2

true

Domain

Histidine-specific methyltransferase, SAM-dependent methyltransferase domain

MTase_SAM-like

1

IPR019258

19,258

Mediator complex, subunit Med4

Mediator_Med4

Family

4,146

false

The Mediator complex is a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. The Mediator complex, having a compact confor...

[ "GO:0003712", "GO:0006357", "GO:0016592" ]

[ "transcription coregulator activity", "regulation of transcription by RNA polymerase II", "mediator complex" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PFAM", "PANTHER" ]

[ "PF10018", "PTHR13208" ]

[ "Med4", "" ]

[ 4019, 3546 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-212436", "R-BTA-9841922", "R-DME-9841922", "R-HSA-1989781", "R-HSA-212436", "R-HSA-381340", "R-HSA-9833110", "R-HSA-9841922", "R-RNO-9841922" ]

[ "REACTOME:R-BTA-212436", "REACTOME:R-BTA-9841922", "REACTOME:R-DME-9841922", "REACTOME:R-HSA-1989781", "REACTOME:R-HSA-212436", "REACTOME:R-HSA-381340", "REACTOME:R-HSA-9833110", "REACTOME:R-HSA-9841922", "REACTOME:R-RNO-9841922" ]

9

[ "5n9j", "5oqm", "5sva", "6w1s", "6xp5", "7emf", "7ena", "7enc", "7enj", "7lbm", "7nvr", "7ui9", "7uif", "7uig", "7uio", "8cen", "8ceo", "8gxq", "8gxs", "8t1i", "8t1l", "8t9d", "8tqw", "8trh" ]

24

[ "PUB00044530", "PUB00044531" ]

[ "10235266", "10235267" ]

[ "Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex.", "Composite co-activator ARC mediates chromatin-directed transcriptional activation." ]

[ 1999, 1999 ]

2

[]

0

null

[ "Eukaryota" ]

[ 4146 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 3, 1, 2, 1, 4, 1, 1, 5, 3, 1, 1, 5 ]

12

true

Family

Mediator complex, subunit Med4

Mediator_Med4

5

IPR019260

19,260

Domain of unknown function DUF2262

DUF2262

Domain

938

false

This entry consists of various hypothetical bacterial proteins with no known function.

[]

0

[ "PFAM" ]

[ "PF10020" ]

[ "DUF2262" ]

[ 938 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Halobacteriales", "human gut metagenome" ]

[ 928, 5, 3, 2 ]

4

[]

0

true

Domain

Domain of unknown function DUF2262

DUF2262

1

IPR019261

19,261

Microbial-type PARG, catalytic domain

PARG_cat_microbial

Domain

6,357

false

This entry represents the catalytic domain of the Poly(ADP-ribose) glycohydrolase (PARG) homologue predominantly found in bacteria and fungi. This enzyme hydrolyses the ribose-ribose bonds present in poly(ADP-ribose) (PAR) chains. Its structure shows a typical macro domain folding consisting of a seven-stranded β-sheet...

[]

0

[ "PFAM" ]

[ "PF10021" ]

[ "PARG_cat_microb" ]

[ 6357 ]

1

[]

0

[ "3sig", "3sih", "3sii", "3sij", "5zda", "5zdb", "5zdc", "5zdd", "5zde", "5zdf", "5zdg" ]

11

[ "PUB00065612", "PUB00100174" ]

[ "21892188", "30940816" ]

[ "The structure and catalytic mechanism of a poly(ADP-ribose) glycohydrolase.", "Structural and biochemical evidence supporting poly ADP-ribosylation in the bacterium Deinococcus radiodurans." ]

[ 2011, 2019 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "Viruses", "metagenomes" ]

[ 2107, 4182, 44, 24 ]

4

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)" ]

[ 1 ]

1

true

Domain

Microbial-type PARG, catalytic domain

PARG_cat_microbial

2

IPR019262

19,262

Domain of unknown function DUF2272

DUF2272

Domain

1,048

false

This is a domain of unknown function found in proteins of unknown function predominantly found in bacteria.

[]

0

[ "PFAM" ]

[ "PF10030" ]

[ "DUF2272" ]

[ 1048 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Caulobacter phage Ccr34", "Eukaryota", "marine sediment metagenome" ]

[ 1042, 1, 3, 2 ]

4

[]

0

true

Domain

Domain of unknown function DUF2272

DUF2272

5

IPR019264

19,264

Domain of unknown function DUF2179

DUF2179

Domain

23,471

false

This entry, found mostly in hypothetical bacterial proteins, has no known function.

[]

0

[ "PFAM" ]

[ "PF10035" ]

[ "DUF2179" ]

[ 23471 ]

1

[]

0

[ "3hlu" ]

1

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Methanobacteriati", "Siphoviridae sp. ctBLh2", "unclassified sequences" ]

[ 23213, 11, 58, 1, 188 ]

5

[]

0

true

Domain

Domain of unknown function DUF2179

DUF2179

3

IPR019265

19,265

RNA transcription, translation and transport factor protein

RTRAF

Family

2,128

false

This entry represents RNA transcription, translation and transport factor protein (RTRAF, also known as hCLE/C14orf166) from eukaryotes. It is part of the DDX1-HSPC117-FAM98B complex that shuttles between the nucleus and the cytoplasm transporting RNAs [ ]. It is also a component of the tRNA-splicing ligase complex and...

[]

0

[ "PFAM", "PANTHER" ]

[ "PF10036", "PTHR15924" ]

[ "RLL", "" ]

[ 2128, 1967 ]

2

[ "GP", "REACTOME" ]

[ "GenProp1707", "R-HSA-6784531" ]

[ "GP:GenProp1707", "REACTOME:R-HSA-6784531" ]

2

[ "7p3a", "9i8v" ]

2

[ "PUB00088061", "PUB00088063", "PUB00088064", "PUB00088066" ]

[ "16950395", "24608264", "24870230", "21900157" ]

[ "hCLE/CGI-99, a human protein that interacts with the influenza virus polymerase, is a mRNA transcription modulator.", "hCLE/C14orf166 associates with DDX1-HSPC117-FAM98B in a novel transcription-dependent shuttling RNA-transporting complex.", "Analysis of orthologous groups reveals archease and DDX1 as tRNA sp...

[ 2006, 2014, 2014, 2011 ]

4

[]

0

null

[ "Eukaryota" ]

[ 2128 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 3, 1, 6, 2, 10 ]

6

true

Family

RNA transcription, translation and transport factor protein

RTRAF

9

IPR019266

19,266

Small ribosomal subunit protein mS27

Ribosomal_mS27

Family

1,798

false

This entry represents the small ribosomal subunit protein mS27 from animals, previously known as MRPS27. This protein binds to the mitochondrial 12S rRNA (12S mt-rRNA) and tRNA(Glu) [ ]. mS27 is involved also in positive regulation of cell proliferation and tumour cell growth [ ].It is a pentatricopeptide repeat domain...

[]

0

[ "PANTHER" ]

[ "PTHR21393" ]

[ "" ]

[ 1798 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-5368286", "R-HSA-5389840", "R-HSA-5419276", "R-HSA-9937383", "R-MMU-5389840", "R-MMU-5419276", "R-MMU-9937383" ]

[ "REACTOME:R-HSA-5368286", "REACTOME:R-HSA-5389840", "REACTOME:R-HSA-5419276", "REACTOME:R-HSA-9937383", "REACTOME:R-MMU-5389840", "REACTOME:R-MMU-5419276", "REACTOME:R-MMU-9937383" ]

7

[ "3j9m", "3jd5", "6gaw", "6gaz", "6neq", "6nf8", "6nu2", "6nu3", "6rw4", "6rw5", "6vlz", "6vmi", "6ydp", "6ydw", "6zm5", "6zm6", "6zs9", "6zsa", "6zsb", "6zsc", "6zsd", "6zse", "6zsg", "7a5f", "7a5g", "7a5i", "7a5k", "7l08", "7nqh", "7nql", "7nsi", "7nsj"...

75

[ "PUB00044382", "PUB00084606", "PUB00151114" ]

[ "17604309", "22841715", "28714366" ]

[ "Reconstructing the evolution of the mitochondrial ribosomal proteome.", "MRPS27 is a pentatricopeptide repeat domain protein required for the translation of mitochondrially encoded proteins.", "High MRPS23 expression contributes to hepatocellular carcinoma proliferation and indicates poor survival outcomes." ]

[ 2007, 2012, 2017 ]

3

[ "IPR034913" ]

[]

1

0

1

[ "Metazoa" ]

[ 1798 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 1, 1, 18, 4, 10 ]

6

true

Family

Small ribosomal subunit protein mS27

Ribosomal_mS27

9

IPR019267

19,267

CRISPR-associated protein Cas6, C-terminal

CRISPR-assoc_Cas6_C

Domain

2,239

false

The CRISPR-Cas system is a prokaryotic defence mechanism against foreign genetic elements. The key elements of this defence system are the Cas proteins and the CRISPR RNA. Cas6 is a member of the RAMP (repeat-associated mysterious protein) superfamily [ ]. It is among the most widely distributed Cas proteins and is fou...

[]

0

[ "PFAM" ]

[ "PF10040" ]

[ "CRISPR_Cas6" ]

[ 2239 ]

1

[]

0

[ "3zfv", "4c8y", "4c8z", "4c97", "4c98", "4c9d", "4ill", "4ilm", "4ilr", "6fjw", "6njy" ]

11

[ "PUB00020781", "PUB00043286", "PUB00043287", "PUB00043288", "PUB00054084", "PUB00060621", "PUB00071890", "PUB00098896" ]

[ "16292354", "17442114", "17379808", "16545108", "19141480", "21699496", "24459147", "24150936" ]

[ "A guild of 45 CRISPR-associated (Cas) protein families and multiple CRISPR/Cas subtypes exist in prokaryotic genomes.", "Evolutionary conservation of sequence and secondary structures in CRISPR repeats.", "CRISPR provides acquired resistance against viruses in prokaryotes.", "A putative RNA-interference-base...

[ 2005, 2007, 2007, 2006, 2008, 2011, 2014, 2014 ]

8

[]

0

null

[ "Archaea", "Bacteria", "unclassified sequences" ]

[ 288, 1924, 27 ]

3

[]

0

true

Domain

CRISPR-associated protein Cas6, C-terminal

CRISPR-assoc_Cas6_C

3

IPR019268

19,268

Protein of unknown function DUF2278

DUF2278

Family

1,967

false

This entry consists of hypothetical proteins with no known function.

[]

0

[ "PFAM" ]

[ "PF10042" ]

[ "DUF2278" ]

[ 1967 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "metagenomes" ]

[ 12, 1312, 641, 2 ]

4

[]

0

true

Family

Protein of unknown function DUF2278

DUF2278

3

IPR019269

19,269

Biogenesis of lysosome-related organelles complex-1, subunit 2

BLOC1_su2

Family

2,687

false

This entry represents a family of proteins that play a role in cellular proliferation, as well as in the biogenesis of specialised organelles of the endosomal-lysosomal system [ ].

[]

0

[ "PFAM", "PANTHER" ]

[ "PF10046", "PTHR46479" ]

[ "BLOC1_2", "" ]

[ 2682, 1890 ]

2

[]

0

[]

0

[ "PUB00043780" ]

[ "15102850" ]

[ "Identification of snapin and three novel proteins (BLOS1, BLOS2, and BLOS3/reduced pigmentation) as subunits of biogenesis of lysosome-related organelles complex-1 (BLOC-1)." ]

[ 2004 ]

1

[]

0

null

[ "Bacteria", "Eukaryota" ]

[ 19, 2668 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 4, 3, 2, 2, 4, 2, 2, 6, 5 ]

9

true

Family

Biogenesis of lysosome-related organelles complex-1, subunit 2

BLOC1_su2

4

IPR019270

19,270

Putative hypoxanthine phosphoribosyltransferase

MM_0201

Family

3,610

false

This entry represents Uncharacterized protein YuzE, Uncharacterized protein MJ0789 and Putative hypoxanthine phosphoribosyltransferase (MM_0201) from prokaryotes. MM_0201 may play a role in purine salvage [ ].

[]

0

[ "PFAM" ]

[ "PF10049" ]

[ "DUF2283" ]

[ 3610 ]

1

[]

0

[]

0

[ "PUB00161756" ]

[ "21941461" ]

[ "Establishing a markerless genetic exchange system for Methanosarcina mazei strain Go1 for constructing chromosomal mutants of small RNA genes." ]

[ 2011 ]

1

[]

[ "IPR016789" ]

0

1

0

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "metagenomes" ]

[ 348, 3054, 59, 23, 126 ]

5

[]

0

true

Family

Putative hypoxanthine phosphoribosyltransferase

MM_0201

6

IPR019271

19,271

Protein of unknown function DUF2284, metal-binding

DUF2284_metal-binding

Family

1,567

false

This entry represents a family of predicted metal-binding bacterial and archaeal proteins with no known function.

[]

0

[ "PFAM", "PIRSF" ]

[ "PF10050", "PIRSF018748" ]

[ "DUF2284", "UCP018748" ]

[ 1567, 250 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Methanophagales virus PBV082", "metagenomes" ]

[ 269, 1221, 1, 76 ]

4

[]

0

true

Family

Protein of unknown function DUF2284, metal-binding

DUF2284_metal-binding

4

IPR019273

19,273

Lunapark zinc ribbon domain

Lunapark_Znf

Domain

5,063

false

This domain, found mainly in the eukaryotic lunapark proteins, has no known function [ ]. It is predicted to fold into a structure typical for zinc ribbon domains. C. elegans lunapark-1, containing this domain, plays a role in synaptogenesis by regulating vesicular transport or localization [ ].

[]

0

[ "PFAM" ]

[ "PF10058" ]

[ "Zn_ribbon_10" ]

[ 5063 ]

1

[]

0

[]

0

[ "PUB00045282", "PUB00075664" ]

[ "12732147", "18279315" ]

[ "A global control region defines a chromosomal regulatory landscape containing the HoxD cluster.", "The evolutionarily conserved gene LNP-1 is required for synaptic vesicle trafficking and synaptic transmission." ]

[ 2003, 2008 ]

2

[]

0

null

[ "Eukaryota", "marine sediment metagenome" ]

[ 5062, 1 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 14, 2, 7, 1, 4, 2, 1, 5, 6, 1, 1, 12 ]

12

true

Domain

Lunapark zinc ribbon domain

Lunapark_Znf

4

IPR019275

19,275

Protein of unknown function DUF2301

DUF2301

Family

1,310

false

This family contains uncharacterised integral membrane proteins.

[]

0

[ "PFAM", "PANTHER" ]

[ "PF10063", "PTHR36716" ]

[ "DUF2301", "" ]

[ 1296, 966 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "hot springs metagenome" ]

[ 649, 660, 1 ]

3

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 4, 3, 18 ]

3

true

Family

Protein of unknown function DUF2301

DUF2301

2

IPR019276

19,276

Protein of unkown function DUF2303

DUF2303

Family

1,752

false

Proteins in this entry are uncharacterised. The characteristics of the protein distribution suggest prophage matches in addition to the phage matches.

[]

0

[ "PFAM" ]

[ "PF10065" ]

[ "DUF2303" ]

[ 1752 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Gibberella intermedia", "Viruses", "metagenomes" ]

[ 1646, 1, 96, 9 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Protein of unkown function DUF2303

DUF2303

7

IPR019277

19,277

Protein of unknown function DUF2304

DUF2304

Family

3,973

false

This entry represents hypothetical archaeal and bacterial proteins that have no known function.

[]

0

[ "PFAM" ]

[ "PF10066" ]

[ "DUF2304" ]

[ 3973 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Durusdinium trenchii", "unclassified sequences" ]

[ 210, 3682, 1, 80 ]

4

[]

0

true

Family

Protein of unknown function DUF2304

DUF2304

8

IPR019282

19,282

Glycoamylase-like, conserved domain

Glycoamylase-like_cons_dom

Domain

7,809

false

This domain adopts an α/α toroid fold, structurally similar to a number of glucoamylases (GH family 15 and 8 enzymes). This domain is also found in some hydrolases, such as ndvB from family and members of the family which includes beta-1,2-glucanases from Parabacteroides distasonis (also known as exo beta-1,2-glucoolig...

[]

0

[ "PFAM" ]

[ "PF10091" ]

[ "Glycoamylase" ]

[ 7809 ]

1

[]

0

[ "3eu8", "4gl3", "4qt9", "5gzh", "5gzk", "5z06", "8rf0", "8rf9", "8rfe", "8rfg", "8wy1", "8xul" ]

12

[ "PUB00099657", "PUB00099658" ]

[ "29763309", "28270506" ]

[ "Characterization and Structural Analysis of a Novel exo-Type Enzyme Acting on β-1,2-Glucooligosaccharides from Parabacteroides distasonis.", "Biochemical and structural analyses of a bacterial <i>endo</i>-β-1,2-glucanase reveal a new glycoside hydrolase family." ]

[ 2018, 2017 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "Methanobacteriota", "metagenomes" ]

[ 7685, 28, 18, 78 ]

4

[]

0

true

Domain

Glycoamylase-like, conserved domain

Glycoamylase-like_cons_dom

2

IPR019284

19,284

Uncharacterized protein RP532

RP532

Family

713

false

This entry consists of proteins from tailed bacteriophages (Caudovirales) and bacteria, including Uncharacterized protein RP532 from Rickettsia prowazekii (strain Madrid E). The characteristics of the protein distribution suggest prophage matches. Members of this family are thought to be membrane proteins.

[]

0

[ "PFAM" ]

[ "PF10097" ]

[ "DUF2335" ]

[ 713 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Arthropoda", "Bacteria", "Caudoviricetes", "ecological metagenomes" ]

[ 2, 696, 8, 7 ]

4

[]

0

true

Family

Uncharacterized protein RP532

RP532

7

IPR019285

19,285

Protein of unknown function DUF2336

DUF2336

Family

4,146

false

Members of this family of hypothetical bacterial proteins have no known function.

[]

0

[ "PFAM" ]

[ "PF10098" ]

[ "DUF2336" ]

[ 4146 ]

1

[]

0

[]

0

[]

0

[]

[ "IPR014598" ]

0

1

0

[ "Eukaryota", "Pseudomonadati", "unclassified sequences" ]

[ 8, 4097, 41 ]

3

[]

0

true

Family

Protein of unknown function DUF2336

DUF2336

7

IPR019286

19,286

Protein of unknown function DUF2339, transmembrane

DUF2339_TM

Family

6,419

false

This entry, found in various hypothetical bacterial proteins, has no known function.

[]

0

[ "PFAM", "PANTHER" ]

[ "PF10101", "PTHR38434" ]

[ "DUF2339", "" ]

[ 6340, 6291 ]

2

[]

0

[]

0

[]

0

[]

[ "IPR014600" ]

0

1

0

[ "Bacteria", "Eukaryota", "Stenosarchaea group", "metagenomes" ]

[ 6315, 11, 38, 55 ]

4

[]

0

true

Family

Protein of unknown function DUF2339, transmembrane

DUF2339_TM

9

IPR019287

19,287

Holliday junction resolvase-related domain

Hday_junct_resolvase-rel_dom

Domain

482

false

This domain is found in various predicted bacterial endonucleases which are distantly related to archaeal Holliday junction resolvases.

[]

0

[ "PFAM" ]

[ "PF10107" ]

[ "Endonuc_Holl" ]

[ 482 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Caenorhabditis remanei", "Viruses", "metagenomes" ]

[ 115, 324, 1, 3, 39 ]

5

[]

0

true

Domain

Holliday junction resolvase-related domain

Hday_junct_resolvase-rel_dom

6

IPR019288

19,288

Predicted 3'-5' exonuclease, PolB-like

3'-5'_exonuclease_PolB-like

Domain

4,346

false

This entry represents various prokaryotic 3'-5' exonucleases and hypothetical proteins.

[]

0

[ "PFAM" ]

[ "PF10108" ]

[ "DNA_pol_B_exo2" ]

[ 4346 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 7, 4161, 21, 54, 103 ]

5

[]

0

true

Domain

Predicted 3'-5' exonuclease, PolB-like

3'-5'_exonuclease_PolB-like

7

IPR019289

19,289

Tail assembly protein E/E'

Phage_tail_E/E'

Family

5,444

false

This entry includes a set of bacteriophage proteins, Tail assembly protein E and E', also known as TAC (tail assembly chaperone) which promote tail assembly by creating a scaffold for the tail tube proteins. Tail assembly proteins E and E' would wrap the linear tape measure protein to create a tail assembly scaffold [ ...

[]

0

[ "PFAM" ]

[ "PF10109" ]

[ "Phage_TAC_7" ]

[ 5444 ]

1

[]

0

[]

0

[ "PUB00015900" ]

[ "11922669" ]

[ "Bacteriophage Mu genome sequence: analysis and comparison with Mu-like prophages in Haemophilus, Neisseria and Deinococcus." ]

[ 2002 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "Viruses", "metagenomes" ]

[ 5226, 20, 179, 19 ]

4

[]

0

true

Family

Tail assembly protein E/E'

Phage_tail_E/E'

3

IPR019290

19,290

Glycosyltransferase 2-like, prokaryotic type

GlycosylTrfase-like_prok

Domain

971

false

This entry represetns a predicted glycosyltransferase domain found in a set of prokaryotic proteins that includes putative glucosyltransferases involved in bacterial capsule biosynthesis [ , ].

[]

0

[ "PFAM" ]

[ "PF10111" ]

[ "Glyco_tranf_2_2" ]

[ 971 ]

1

[]

0

[]

0

[ "PUB00008114", "PUB00044283" ]

[ "9515923", "11953367" ]

[ "Characterization of the gene cassette required for biosynthesis of the (alpha1-->6)-linked N-acetyl-D-mannosamine-1-phosphate capsule of serogroup A Neisseria meningitidis.", "Novel Aeromonas hydrophila PPD134/91 genes involved in O-antigen and capsule biosynthesis." ]

[ 1998, 2002 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "Methanobacteriota", "Mycobacterium phage Phrappuccino", "ecological metagenomes" ]

[ 937, 9, 5, 1, 19 ]

5

[]

0

true

Domain

Glycosyltransferase 2-like, prokaryotic type

GlycosylTrfase-like_prok

8

IPR019291

19,291

Host attachment protein

Host_attachment_protein

Family

1,990

false

Members of this family of bacterial proteins are required for the attachment of the bacterium to host cells [ , ].

[]

0

[ "PFAM" ]

[ "PF10116" ]

[ "Host_attach" ]

[ 1990 ]

1

[]

0

[]

0

[ "PUB00035634", "PUB00044304" ]

[ "12024217", "10786639" ]

[ "Comparison of the genomes of two Xanthomonas pathogens with differing host specificities.", "A region of the Agrobacterium tumefaciens chromosome containing genes required for virulence and attachment to host cells." ]

[ 2002, 2000 ]

2

[]

0

null

[ "Bacteria", "Chiloscyllium punctatum", "unclassified sequences" ]

[ 1967, 1, 22 ]

3

[]

0

true

Family

Host attachment protein

Host_attachment_protein

9

IPR019292

19,292

Type IV methyl-directed restriction enzyme EcoKMcrBC

McrC

Family

5,604

false

Members of this family of prokaryotic endonucleases modify the specificity of McrB restriction by expanding the range of modified sequences that are restricted [ , ]. It does not bind DNA. Type IV methyl-directed restriction enzyme EcoKMcrBC (McrC) adopts a dimeric configuration while free and form tetradecamers of 12 ...

[]

0

[ "PFAM", "PANTHER" ]

[ "PF10117", "PTHR38733" ]

[ "McrBC", "" ]

[ 5591, 5319 ]

2

[]

0

[ "6hz4", "6hz5", "6hz6", "6hz7", "6hz8", "6hz9", "6ut5", "6ut6", "6ut7", "6ut8", "7vsr" ]

11

[ "PUB00044348", "PUB00044349", "PUB00100362" ]

[ "2203735", "2050643", "31296862" ]

[ "Genetic and sequence organization of the mcrBC locus of Escherichia coli K-12.", "Overproduction and purification of McrC protein from Escherichia coli K-12.", "Structure-based mechanism for activation of the AAA+ GTPase McrB by the endonuclease McrC." ]

[ 1990, 1991, 2019 ]

3

[]

[ "IPR014407" ]

0

1

0

[ "Archaea", "Bacteria", "Eukaryota", "Siphoviridae sp. cte421", "metagenomes" ]

[ 217, 5315, 7, 1, 64 ]

5

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Type IV methyl-directed restriction enzyme EcoKMcrBC

McrC

2

IPR019293

19,293

Thiamine-phosphate synthase ThiN-like

ThiN-like

Domain

1,544

false

Thiamine-phosphate synthase ThiN condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) [ ]. This enzyme is sometimes part of a bifunctional thiamine biosynthesis protein which also includes ThiD (a hydrox...

[]

0

[ "PFAM" ]

[ "PF10120" ]

[ "ThiN" ]

[ 1544 ]

1

[ "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC" ]

[ "2.5.1.3", "PWY-6893", "PWY-6894", "PWY-6897", "PWY-6907", "PWY-6908", "PWY-7356", "PWY-8457" ]

[ "EC:2.5.1.3", "METACYC:PWY-6893", "METACYC:PWY-6894", "METACYC:PWY-6897", "METACYC:PWY-6907", "METACYC:PWY-6908", "METACYC:PWY-7356", "METACYC:PWY-8457" ]

8

[ "2pb9", "2php" ]

2

[ "PUB00058067", "PUB00070802", "PUB00154441" ]

[ "12794638", "10075431", "28115546" ]

[ "Systematic discovery of analogous enzymes in thiamin biosynthesis.", "Cloning and characterization of the thiD/J gene of Escherichia coli encoding a thiamin-synthesizing bifunctional enzyme, hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase.", "ThiN as a Versatile Domain of Transcriptional Represso...

[ 2003, 1999, 2017 ]

3

[]

0

null

[ "Archaea", "Bacteria", "Geodia barretti", "ecological metagenomes" ]

[ 1385, 112, 2, 45 ]

4

[]

0

true

Domain

Thiamine-phosphate synthase ThiN-like

ThiN-like

8

IPR019294

19,294

Translational regulator Com

Translation_reg_Com

Family

874

false

Com is a bacteriophage protein that acts as a translational regulator of the DNA modification protein Mom [ , ]. Binding of Com to the translation intitation region of the mom gene causes a conformational change that is thought to enhancing ribosome binding [ ].

[]

0

[ "PFAM" ]

[ "PF10122" ]

[ "Zn_ribbon_Com" ]

[ 874 ]

1

[]

0

[]

0

[ "PUB00015900", "PUB00044385", "PUB00056673" ]

[ "11922669", "6345072", "1826635" ]

[ "Bacteriophage Mu genome sequence: analysis and comparison with Mu-like prophages in Haemophilus, Neisseria and Deinococcus.", "Methylation regulates the expression of a DNA-modification function encoded by bacteriophage Mu.", "Translational stimulation: RNA sequence and structure requirements for binding of Co...

[ 2002, 1983, 1991 ]

3

[]

0

null

[ "Bacteria", "Viruses", "metagenomes" ]

[ 851, 15, 8 ]

3

[]

0

true

Family

Translational regulator Com

Translation_reg_Com

8

IPR019296

19,296

Uncharacterised protein family, nitrogen regulatory protein PII-related

Unchr_N-regulatory-PII-rel

Family

73

false

This family of hypothetical archaeal proteins has no known function. They are distantly similar to the nitrogen regulatory protein PII.

[]

0

[ "PFAM" ]

[ "PF10126" ]

[ "Nit_Regul_Hom" ]

[ 73 ]

1

[]

0

[]

0

[]

0

[]

[ "IPR024184" ]

0

1

0

[ "Methanobacteriota", "hydrocarbon metagenome" ]

[ 72, 1 ]

2

[]

0

true

Family

Uncharacterised protein family, nitrogen regulatory protein PII-related

Unchr_N-regulatory-PII-rel

8

IPR019300

19,300

CO dehydrogenase accessory protein CooT

CooT

Family

736

false

CooT is an accessory protein required for maturation of Carbon Monoxide Dehydrogenase (CODH). It is a member of a Ni(ii)-binding protein family, linked to anaerobic metabolism in bacteria and archaea, and in most cases to the presence of CODH. Structure analysis indicates that it is a homodimer featuring a fold that re...

[]

0

[ "PFAM" ]

[ "PF10133" ]

[ "CooT" ]

[ 736 ]

1

[]

0

[ "5n76", "6fan", "6y8v", "6y8w" ]

4

[ "PUB00091039" ]

[ "28447092" ]

[ "The CO dehydrogenase accessory protein CooT is a novel nickel-binding protein." ]

[ 2017 ]

1

[]

0

null

[ "Archaea", "Bacteria", "ecological metagenomes" ]

[ 196, 505, 35 ]

3

[]

0

true

Family

CO dehydrogenase accessory protein CooT

CooT

7

IPR019301

19,301

Flagellar protein FlgJ, N-terminal

Flagellar_prot_FlgJ_N

Domain

9,920

false

The N-terminal domain of the FlgJ protein is directly involved in flagellar rod assembly, while the adjacent C-terminal domain is a flagellum-specific muramidase (peptidoglycan hydrolase) required for formation of the outer membrane L ring [ ].

[]

0

[ "PFAM" ]

[ "PF10135" ]

[ "Rod-binding" ]

[ 9920 ]

1

[]

0

[]

0

[ "PUB00020765" ]

[ "11554792" ]

[ "The role in flagellar rod assembly of the N-terminal domain of Salmonella FlgJ, a flagellum-specific muramidase." ]

[ 2001 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 9803, 13, 104 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Domain

Flagellar protein FlgJ, N-terminal

Flagellar_prot_FlgJ_N

5

IPR019302

19,302

CD-NTase-associated protein 12/Pycsar effector protein, TIR domain

CAP12/PCTIR_TIR_dom

Domain

2,446

false

This entry represents a TIR domain found in prokaryotic nucleotide-binding proteins, including CD-NTase-associated protein 12 (CAP12) and Pycsar effector proteins ( ). Members of this entry are part of anti phage resistance systems that provide immunity against bacteriophage. CAP12 is part of the CBASS (cyclic oligonuc...

[ "GO:0050135" ]

[ "NADP+ nucleosidase activity" ]

[ "molecular_function" ]

1

[ "PFAM" ]

[ "PF10137" ]

[ "CAP12-PCTIR_TIR" ]

[ 2446 ]

1

[ "EC" ]

[ "3.2.2.5" ]

[ "EC:3.2.2.5" ]

1

[ "7un8", "7un9", "7una", "8jsj", "9lmq", "9lmr" ]

6

[ "PUB00096608", "PUB00101269" ]

[ "32839535", "32877915" ]

[ "Diversity and classification of cyclic-oligonucleotide-based anti-phage signalling systems.", "STING cyclic dinucleotide sensing originated in bacteria." ]

[ 2020, 2020 ]

2

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "metagenomes" ]

[ 18, 2366, 14, 2, 46 ]

5

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Domain

CD-NTase-associated protein 12/Pycsar effector protein, TIR domain

CAP12/PCTIR_TIR_dom

7

IPR019303

19,303

vWA found in TerF C terminus

vWA_TerF_C

Domain

3,513

false

vWA domain fused to TerD domain typified by the TerF protein [ ]. Sometimes it is found as solos.

[]

0

[ "PFAM" ]

[ "PF10138" ]

[ "vWA-TerF-like" ]

[ 3513 ]

1

[]

0

[]

0

[ "PUB00066658" ]

[ "23044854" ]

[ "Ter-dependent stress response systems: novel pathways related to metal sensing, production of a nucleoside-like metabolite, and DNA-processing." ]

[ 2012 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "Viruses", "marine sediment metagenome" ]

[ 3265, 143, 102, 3 ]

4

[]

0

true

Domain

vWA found in TerF C terminus

vWA_TerF_C

2

IPR019305

19,305

Uncharacterised protein family Smp

Uncharacterised_Smp

Family

2,649

false

This entry represents a group of bacterial proteins that are membrane proteins that effect the expression of haemolysin under anaerobic conditions [ ].

[]

0

[ "PFAM" ]

[ "PF10144" ]

[ "SMP_2" ]

[ 2649 ]

1

[]

0

[]

0

[ "PUB00044492" ]

[ "10699510" ]

[ "Cloning and characterisation of the Pasteurella multocida ahpA gene responsible for a haemolytic phenotype in Escherichia coli." ]

[ 2000 ]

1

[]

0

null

[ "Bacteria", "Neoptera", "metagenomes" ]

[ 2643, 2, 4 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Uncharacterised protein family Smp

Uncharacterised_Smp

3

IPR019306

19,306

Transmembrane protein 231

TMEM231

Family

2,022

false

The proteins in this entry belong to transmembrane protein family 231; they have no known function.

[]

0

[ "PFAM", "PANTHER" ]

[ "PF10149", "PTHR14605" ]

[ "TM231", "" ]

[ 2021, 1912 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Eukaryota" ]

[ 2022 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 1, 2, 13, 2, 3 ]

6

true

Family

Transmembrane protein 231

TMEM231

8

IPR019307

19,307

RNA-binding protein AU-1/Ribonuclease E/G

RNA-bd_AU-1/RNase_E/G

Domain

30,699

false

This entry represents ribonuclease E/G and RNA-binding protein AU-1. Ribonuclease E and ribonuclease G are related enzymes that cleave a wide variety of RNAs [ ]. RNA-binding protein AU-1 binds to RNA loop regions that are with AU-rich sequences [ , ].

[ "GO:0003723" ]

[ "RNA binding" ]

[ "molecular_function" ]

1

[ "PFAM" ]

[ "PF10150" ]

[ "RNase_E_G" ]

[ 30699 ]

1

[ "EC", "GP" ]

[ "3.1.26.-", "GenProp1360" ]

[ "EC:3.1.26.-", "GP:GenProp1360" ]

2

[ "2bx2", "2c0b", "2c4r", "2vmk", "2vrt", "4oxp", "5f6c", "6g63", "6x2d", "8b0j", "8rza", "8wo8" ]

12

[ "PUB00033641", "PUB00035944", "PUB00156048" ]

[ "16237448", "12614195", "38302756" ]

[ "Structure of Escherichia coli RNase E catalytic domain and implications for RNA turnover.", "Expression cloning and characterization of a novel gene that encodes the RNA-binding protein FAU-1 from Pyrococcus furiosus.", "Homo-trimeric structure of the ribonuclease for rRNA processing, FAU-1, from Pyrococcus fu...

[ 2005, 2003, 2024 ]

3

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 66, 28935, 1063, 635 ]

4

[ "Arabidopsis thaliana", "Escherichia coli (strain K12)", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 5, 2, 5, 8 ]

4

true

Domain

RNA-binding protein AU-1/Ribonuclease E/G

RNA-bd_AU-1/RNase_E/G

5

IPR019309

19,309

WASH complex subunit 3

WASHC3

Family

3,204

false

The WASH (WASP and Scar homologue) complex is present at the surface of endosomes and recruits and activates the Arp2/3 complex to induce mediated actin nucleation. The WASH complex plays a key role in the fission of tubules that serve as transport intermediates during endosome sorting [ ]. The WASH complex consists of...

[ "GO:0071203" ]

[ "WASH complex" ]

[ "cellular_component" ]

1

[ "PFAM", "PANTHER" ]

[ "PF10152", "PTHR13015" ]

[ "CCDC53", "" ]

[ 3197, 2287 ]

2

[]

0

[]

0

[ "PUB00054152" ]

[ "19922875" ]

[ "The Arp2/3 activator WASH controls the fission of endosomes through a large multiprotein complex." ]

[ 2009 ]

1

[]

0

null

[ "Eukaryota", "Mimiviridae sp. ChoanoV1", "viral metagenome" ]

[ 3194, 1, 9 ]

3

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus" ]

[ 1, 1, 1, 8, 6, 4, 7 ]

7

true

Family

WASH complex subunit 3

WASHC3

3

IPR019310

19,310

rRNA-processing protein Efg1

Efg1

Family

2,752

false

This entry represents the rRNA-processing protein Efg1 family. Efg1 is involved in rRNA processing [ , ].

[ "GO:0006364" ]

[ "rRNA processing" ]

[ "biological_process" ]

1

[ "PFAM" ]

[ "PF10153" ]

[ "Efg1" ]

[ 2752 ]

1

[]

0

[ "5yma" ]

1

[ "PUB00014725", "PUB00078912" ]

[ "12837249", "16510898" ]

[ "A panoramic view of yeast noncoding RNA processing.", "Functional genomics of genes with small open reading frames (sORFs) in S. cerevisiae." ]

[ 2003, 2006 ]

2

[]

0

null

[ "Eukaryota" ]

[ 2752 ]

1

[ "Arabidopsis thaliana", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)", "Zea mays" ]

[ 14, 1, 3, 1, 1, 13 ]

6

true

Family

rRNA-processing protein Efg1

Efg1

2

IPR019311

19,311

Ferry endosomal RAB5 effector complex subunit 3

Fy-3

Family

2,255

false

This entry represents a human Ferry endosomal RAB5 effector complex subunit 3 (Fy-3) and similar sequences from animals and some fungal species. Fy-3 is a component of the FERRY complex (Five-subunit Endosomal Rab5 and RNA/ribosome intermediary), which directly interacts with mRNAs and RAB5A, and functions as a RAB5A e...

[]

0

[ "PFAM", "PANTHER" ]

[ "PF10154", "PTHR16525" ]

[ "Fy-3", "" ]

[ 2242, 2205 ]

2

[]

0

[]

0

[ "PUB00153730" ]

[ "37267905" ]

[ "The Rab5 effector FERRY links early endosomes with mRNA localization." ]

[ 2023 ]

1

[]

0

null

[ "Eukaryota" ]

[ 2255 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 3, 6, 1, 4, 3, 2 ]

6

true

Family

Ferry endosomal RAB5 effector complex subunit 3

Fy-3

8

IPR019312

19,312

CCR4-NOT transcription complex subunit 11, C-terminal domain

CNOT11_C

Domain

3,636

false

The CCR4-NOT complex plays a key role in mRNA decay in all eukaryotes, thereby contributing importantly to gene expression regulation [ ]. Human C2ORF29 proteins, also known as CNOT11, is a component of the CCR4-NOT complex. CNOT11 interacts with the first amino acids of CNOT1 and with CNOT10 and is required for the as...

[ "GO:0030014" ]

[ "CCR4-NOT complex" ]

[ "cellular_component" ]

1

[ "PFAM", "PANTHER" ]

[ "PF10155", "PTHR15975" ]

[ "CNOT11", "" ]

[ 3362, 3281 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-DDI-6804115", "R-DRE-6804115", "R-HSA-429947", "R-HSA-6804115", "R-HSA-9820841", "R-MMU-429947", "R-MMU-6804115", "R-RNO-6804115" ]

[ "REACTOME:R-DDI-6804115", "REACTOME:R-DRE-6804115", "REACTOME:R-HSA-429947", "REACTOME:R-HSA-6804115", "REACTOME:R-HSA-9820841", "REACTOME:R-MMU-429947", "REACTOME:R-MMU-6804115", "REACTOME:R-RNO-6804115" ]

8

[ "8bfh", "8bfi", "8bfj", "8fy3", "8fy4" ]

5

[ "PUB00083181", "PUB00083182" ]

[ "23232451", "23303381" ]

[ "C2ORF29/CNOT11 and CNOT10 form a new module of the CCR4-NOT complex.", "NOT10 and C2orf29/NOT11 form a conserved module of the CCR4-NOT complex that docks onto the NOT1 N-terminal domain." ]

[ 2013, 2013 ]

2

[]

0

null

[ "Eukaryota" ]

[ 3636 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 11, 4, 2, 2, 3, 3, 9, 2, 25 ]

9

true

Domain

CCR4-NOT transcription complex subunit 11, C-terminal domain

CNOT11_C

1

IPR019313

19,313

Mediator complex, subunit Med17

Mediator_Med17

Family

4,677

false

The Mediator complex is a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. The Mediator complex, having a compact confor...

[ "GO:0003712", "GO:0006357", "GO:0016592" ]

[ "transcription coregulator activity", "regulation of transcription by RNA polymerase II", "mediator complex" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PFAM", "PANTHER" ]

[ "PF10156", "PTHR13114" ]

[ "Med17", "" ]

[ 3242, 4562 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-212436", "R-BTA-9841922", "R-DME-9841922", "R-HSA-1989781", "R-HSA-212436", "R-HSA-381340", "R-HSA-9833110", "R-HSA-9841922" ]

[ "REACTOME:R-BTA-212436", "REACTOME:R-BTA-9841922", "REACTOME:R-DME-9841922", "REACTOME:R-HSA-1989781", "REACTOME:R-HSA-212436", "REACTOME:R-HSA-381340", "REACTOME:R-HSA-9833110", "REACTOME:R-HSA-9841922" ]

8

[ "3j1o", "3rj1", "4gwp", "4gwq", "4h62", "4h63", "4v1o", "5n9j", "5oqm", "5sva", "5u0p", "5u0s", "6w1s", "6xp5", "7emf", "7ena", "7enc", "7enj", "7lbm", "7nvr", "7ui9", "7uif", "7uig", "7uio", "8cen", "8ceo", "8gxq", "8gxs", "8t1i", "8t1l", "8t9d", "8tqw"...

33

[]

0

[]

0

null

[ "Eukaryota", "Paenibacillus odorifer" ]

[ 4676, 1 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 4, 1, 3, 1, 17, 3, 1, 3, 4, 1, 1, 10 ]

12

true

Family

Mediator complex, subunit Med17

Mediator_Med17

7

IPR019314

19,314

BLOC-1-related complex subunit 6

BORCS6

Family

1,494

false

BORC is a multisubunit complex that regulates the positioning of lysosomes at the cell periphery, and consequently affects cell migration. BORC associates with the lysosomal membrane, where it functions to recruit the small GTPase Arl8. This initiates a series of interactions that promote the microtubule-guided transpo...

[]

0

[ "PANTHER" ]

[ "PTHR13440" ]

[ "" ]

[ 1494 ]

1

[]

0

[]

0

[ "PUB00074975", "PUB00082308" ]

[ "25898163", "25898167" ]

[ "BORC and BLOC-1: Shared Subunits in Trafficking Complexes.", "BORC, a multisubunit complex that regulates lysosome positioning." ]

[ 2015, 2015 ]

2

[]

0

null

[ "Eukaryota" ]

[ 1494 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 1, 2, 2, 1, 1 ]

6

true

Family

BLOC-1-related complex subunit 6

BORCS6

1

IPR019315

19,315

Multiple myeloma tumor-associated protein 2-like, N-terminal

MMTA2_N

Domain

3,146

false

This entry represents a glycine-rich domain found in MMTA2 (multiple myeloma tumor-associated protein 2). The region may contain nuclear localisation signals, so it might act as a signal molecule in the nucleus [ , ].

[]

0

[ "PFAM" ]

[ "PF10159" ]

[ "MMtag" ]

[ 3146 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-6798695", "R-MMU-6798695", "R-RNO-6798695", "R-SPO-6798695" ]

[ "REACTOME:R-HSA-6798695", "REACTOME:R-MMU-6798695", "REACTOME:R-RNO-6798695", "REACTOME:R-SPO-6798695" ]

4

[]

0

[ "PUB00044371", "PUB00091038" ]

[ "12545221", "20663773" ]

[ "Cloning and sequence analysis of tumor-associated gene hMMTAG2 from human multiple myeloma cell line ARH-77.", "Characterization and prediction of protein nucleolar localization sequences." ]

[ 2003, 2010 ]

2

[]

0

null

[ "Eukaryota" ]

[ 3146 ]

1

[ "Arabidopsis thaliana", "Danio rerio", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)", "Zea mays" ]

[ 2, 3, 1, 1, 1, 2, 4, 1, 2 ]

9

true

Domain

Multiple myeloma tumor-associated protein 2-like, N-terminal

MMTA2_N

2

IPR019316

19,316

G8 domain

G8_domain

Domain

5,917

false

This entry represents a domain found in disease proteins PKHD1 and CEMIP2 (also known as KIAA1199) and is named G8 after its 8 conserved glycines. It is predicted to contain 10 β-strands and an α-helix [ , ]. CEMIP2 is an inactive cell surface hyaluronidase that, unlike its mouse orthologue, has no catalytic hyaluronic...

[]

0

[ "PFAM", "PROFILE", "SMART" ]

[ "PF10162", "PS51484", "SM01225" ]

[ "G8", "G8", "G8" ]

[ 5817, 5725, 5555 ]

3

[ "REACTOME", "REACTOME", "REACTOME" ]

[ "R-DDI-2160916", "R-HSA-2160916", "R-MMU-2160916" ]

[ "REACTOME:R-DDI-2160916", "REACTOME:R-HSA-2160916", "REACTOME:R-MMU-2160916" ]

3

[ "8c6i" ]

1

[ "PUB00044276", "PUB00151552", "PUB00153307" ]

[ "16632497", "37196767", "37234743" ]

[ "G8: a novel domain associated with polycystic kidney disease and non-syndromic hearing loss.", "Human TMEM2 is not a catalytic hyaluronidase, but a regulator of hyaluronan metabolism via HYBID (KIAA1199/CEMIP) and HAS2 expression.", "Structure of the transmembrane protein 2 (TMEM2) ectodomain and its apparent ...

[ 2006, 2023, 2023 ]

3

[]

0

null

[ "Bacteria", "Eukaryota", "Halobacteriales", "metagenomes" ]

[ 488, 5394, 28, 7 ]

4

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 12, 7, 10, 13 ]

4

true

Domain

G8 domain

G8_domain

8

IPR019317

19,317

Membrane protein BRI3

BRI3

Family

1,942

false

This is a highly conserved set of proteins which contains three pairs of cysteine residues within a length of 42 amino acids and is rich in proline residues towards the N terminus. It includes a membrane protein that has been found to be highly expressed in the mouse brain and consequently, several members have been as...

[]

0

[ "PFAM", "PANTHER" ]

[ "PF10164", "PTHR13551" ]

[ "BRI3", "" ]

[ 1861, 1549 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-6798695", "R-HSA-6798695", "R-MMU-6798695", "R-RNO-6798695" ]

[ "REACTOME:R-BTA-6798695", "REACTOME:R-HSA-6798695", "REACTOME:R-MMU-6798695", "REACTOME:R-RNO-6798695" ]

4

[]

0

[ "PUB00083183", "PUB00095376", "PUB00151123" ]

[ "11290423", "14592447", "20538055" ]

[ "Sequence, genomic structure and tissue expression of Human BRI3, a member of the BRI gene family.", "bri3, a novel gene, participates in tumor necrosis factor-alpha-induced cell death.", "Analysis of the Wnt/B-catenin/TCF4 pathway using SAGE, genome-wide microarray and promoter analysis: Identification of BRI3...

[ 2001, 2003, 2010 ]

3

[]

0

null

[ "Eukaryota", "Sphingobacterium haloxyli", "freshwater metagenome" ]

[ 1940, 1, 1 ]

3

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 1, 2, 1, 4, 2 ]

6

true

Family

Membrane protein BRI3

BRI3

7

IPR019319

19,319

Plasminogen receptor (KT)

Plg-R(KT)

Family

1,348

false

Plg-R(KT) is a receptor for plasminogen and is involved in the plasminogen-dependent regulation of macrophage invasion, chemotactic migration, and recruitment in the inflammatory response [ ]. It is essential for mammary lobuloalveolar development and lactation [ ].

[ "GO:0010756", "GO:0005886" ]

[ "positive regulation of plasminogen activation", "plasma membrane" ]

[ "biological_process", "cellular_component" ]

2

[ "PFAM", "PANTHER" ]

[ "PF10166", "PTHR13411" ]

[ "DUF2368", "" ]

[ 1347, 1286 ]

2

[]

0

[]

0

[ "PUB00092490", "PUB00092491" ]

[ "21940822", "29495105" ]

[ "Regulation of macrophage migration by a novel plasminogen receptor Plg-R KT.", "The plasminogen receptor, Plg-RKT, is essential for mammary lobuloalveolar development and lactation." ]

[ 2011, 2018 ]

2

[]

0

null

[ "Eukaryota" ]

[ 1348 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 1, 2, 1, 3, 2 ]

6

true

Family

Plasminogen receptor (KT)

Plg-R(KT)

8

IPR019320

19,320

BLOC-1-related complex subunit 8

BORCS8

Family

3,320

false

BORC is a multisubunit complex that regulates the positioning of lysosomes at the cell periphery, and consequently affects cell migration. BORC associates with the lysosomal membrane, where it functions to recruit the small GTPase Arl8. This initiates a series of interactions that promote the microtubule-guided transpo...

[]

0

[ "PFAM", "PANTHER" ]

[ "PF10167", "PTHR21146" ]

[ "BORCS8", "" ]

[ 3284, 3043 ]

2

[]

0

[]

0

[ "PUB00074975", "PUB00082308" ]

[ "25898163", "25898167" ]

[ "BORC and BLOC-1: Shared Subunits in Trafficking Complexes.", "BORC, a multisubunit complex that regulates lysosome positioning." ]

[ 2015, 2015 ]

2

[]

0

null

[ "Eukaryota" ]

[ 3320 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 2, 1, 2, 1, 2, 3, 2, 4, 5 ]

9

true

Family

BLOC-1-related complex subunit 8

BORCS8

8

IPR019321

19,321

Nucleoporin Nup88

Nucleoporin_Nup88

Family

3,205

false

Nup88 can be divided into two structural domains; the N-terminal two-thirds of the protein have no obvious structural motifs. It is, however, where it binds to Nup98; one of the components of the nuclear pore. The C-terminal end is a predicted coiled-coil domain [ ]. Nup88 is over expressed in tumour cells [ ]. This pr...

[]

0

[ "PFAM" ]

[ "PF10168" ]

[ "Nup88" ]

[ 3205 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-DME-159227", "R-DME-159230", "R-DME-159231", "R-DME-159236", "R-DME-170822", "R-DME-3108214", "R-DME-3301854", "R-DME-4085377", "R-DME-4551638", "R-DME-4615885", "R-DME-5578749", "R-HSA-1169408", "R-HSA-159227", "R-HSA-159230", "R-HSA-159231", "R-HSA-159236", "R-HSA-165054", "R-...

[ "REACTOME:R-DME-159227", "REACTOME:R-DME-159230", "REACTOME:R-DME-159231", "REACTOME:R-DME-159236", "REACTOME:R-DME-170822", "REACTOME:R-DME-3108214", "REACTOME:R-DME-3301854", "REACTOME:R-DME-4085377", "REACTOME:R-DME-4551638", "REACTOME:R-DME-4615885", "REACTOME:R-DME-5578749", "REACTOME:R-H...

78

[ "7fik", "7mni", "7r5j", "7r5k", "7tbl", "7tbm", "7tdz", "7vop", "9hcj", "9sob" ]

10

[ "PUB00044407", "PUB00044408", "PUB00151910" ]

[ "9049309", "12589057", "30543681" ]

[ "The human homologue of yeast CRM1 is in a dynamic subcomplex with CAN/Nup214 and a novel nuclear pore component Nup88.", "Nup98 localizes to both nuclear and cytoplasmic sides of the nuclear pore and binds to two distinct nucleoporin subcomplexes.", "Biallelic mutations in nucleoporin NUP88 cause lethal fetal ...

[ 1997, 2003, 2018 ]

3

[ "IPR037700" ]

[]

1

0

1

[ "Eukaryota", "Pseudomonadati" ]

[ 3202, 3 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)", "Zea mays" ]

[ 6, 1, 1, 1, 26, 6, 6, 5, 2, 8 ]

10

true

Family

Nucleoporin Nup88

Nucleoporin_Nup88

8

IPR019322

19,322

Mitochondrial import inner membrane translocase subunit Tim29

TIMM29

Family

1,241

false

This entry includes mitochondrial import inner membrane translocase subunit Tim29 (TIMM29), which is a component of the TIM22 complex. The TIM22 complex imports and inserts multi-pass transmembrane proteins into the mitochondrial inner membrane by formation of a twin-pore translocase with components in the outer and in...

[ "GO:0042721" ]

[ "TIM22 mitochondrial import inner membrane insertion complex" ]

[ "cellular_component" ]

1

[ "PFAM", "PANTHER" ]

[ "PF10171", "PTHR21435" ]

[ "Tim29", "" ]

[ 1239, 1196 ]

2

[]

0

[ "7cgp" ]

1

[ "PUB00083238" ]

[ "27554484" ]

[ "Tim29 is a novel subunit of the human TIM22 translocase and is involved in complex assembly and stability." ]

[ 2016 ]

1

[]

0

null

[ "Opisthokonta" ]

[ 1241 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 1, 1, 1, 1, 2 ]

6

true

Family

Mitochondrial import inner membrane translocase subunit Tim29

TIMM29

5

IPR019323

19,323

ELKS/Rab6-interacting/CAST family member 1

ELKS/CAST

Family

6,654

false

This entry represents the ELKS family, which are thought to be involved in the organisation of CAZ. Vertebrate ELKS proteins are produced by two genes, ERC1 and ERC2. Caenorhabditis elegans expresses a homologue of ELKS that acts downstream of syd2/liprin-alpha during active zone assembly [ ]. Drosophila melanogaster e...

[]

0

[ "PFAM" ]

[ "PF10174" ]

[ "Cast" ]

[ 6654 ]

1

[]

0

[ "8i3e", "8ij9", "8whm" ]

3

[ "PUB00044182", "PUB00072837", "PUB00073367", "PUB00073370", "PUB00073372", "PUB00073388" ]

[ "12391317", "17115037", "22933801", "25209271", "16543132", "24348337" ]

[ "A family of RIM-binding proteins regulated by alternative splicing: Implications for the genesis of synaptic active zones.", "SYD-2 Liprin-alpha organizes presynaptic active zone formation through ELKS.", "Deletion of the presynaptic scaffold CAST reduces active zone size in rod photoreceptors and impairs visu...

[ 2002, 2006, 2012, 2014, 2006, 2013 ]

6

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota" ]

[ 3, 14, 6637 ]

3

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 37, 12, 14, 18, 22 ]

6

true

Family

ELKS/Rab6-interacting/CAST family member 1

ELKS/CAST

1

IPR019325

19,325

NEDD4/Bsd2

Family

4,940

false

Proteins in this entry include the human NEDD4 family-interacting protein 1/2 (Ndfip1 and Ndfip2) and the yeast Bsd2 metal homeostasis proteins. Ndfip1 and Ndfip2 are endosomal membrane proteins that bind to and activate members of the Nedd4 family of E3 ubiquitin ligases [ , ]. Ndfip1 plays a role in regulating metal ...

[ "GO:0007034", "GO:0030001" ]

[ "vacuolar transport", "metal ion transport" ]

[ "biological_process", "biological_process" ]

2

[ "PFAM", "PANTHER" ]

[ "PF10176", "PTHR13396" ]

[ "NEDD4_Bsd2", "" ]

[ 4861, 4865 ]

2

[]

0

[]

0

[ "PUB00075323", "PUB00075324", "PUB00075325", "PUB00075326", "PUB00075327" ]

[ "20534535", "19706893", "19343052", "17429078", "9115231" ]

[ "Regulation of PTEN/Akt and MAP kinase signaling pathways by the ubiquitin ligase activators Ndfip1 and Ndfip2.", "Divalent metal transporter 1 (DMT1) regulation by Ndfip1 prevents metal toxicity in human neurons.", "Control of the activity of WW-HECT domain E3 ubiquitin ligases by NDFIP proteins.", "Multiple...

[ 2010, 2009, 2009, 2007, 1997 ]

5

[]

0

null

[ "Opisthokonta", "Streptomyces actuosus", "viral metagenome" ]

[ 4938, 1, 1 ]

3

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 6, 1, 16, 10, 1, 10, 1, 1 ]

8

true

Family

NEDD4/Bsd2

1

IPR019326

19,326

Protein NDNF

NDNF

Family

3,367

false

NDNF (neuron-derived neurotrophic factor) is a glycosylated, disulfide-bonded secretory protein that contains fibronectin type III domains and two predicted N-linked glycosylation sites [ , ]. It is expressed in brain and spinal cord that promotes migration and neurite growth. It acts as a modulator that promotes endot...

[]

0

[ "PANTHER" ]

[ "PTHR14619" ]

[ "" ]

[ 3367 ]

1

[]

0

[ "1li1", "1m3d", "1t60", "1t61", "5nax", "5nay", "5naz", "5nb0", "5nb1", "5nb2", "6mpx", "6wku", "8txn", "8tys" ]

14

[ "PUB00092492", "PUB00092493" ]

[ "24706764", "20969804" ]

[ "Neuron-derived neurotrophic factor functions as a novel modulator that enhances endothelial cell function and revascularization processes.", "Spatio-temporal expression of a novel neuron-derived neurotrophic factor (NDNF) in mouse brains during development." ]

[ 2014, 2010 ]

2

[]

0

null

[ "Opisthokonta" ]

[ 3367 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 4, 4, 10, 3, 5 ]

6

true

Family

Protein NDNF

NDNF

8

IPR019327

19,327

WKF domain

WKF

Domain

2,849

false

This entry represents a domain found in a family of proteins found from fungi and animals. The domain is named WKF after a conserved sequence motif. This domain has been shown to bind RNA [ ].

[]

0

[ "PFAM" ]

[ "PF10180" ]

[ "WKF" ]

[ 2849 ]

1

[]

0

[]

0

[ "PUB00101041" ]

[ "30528433" ]

[ "The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest." ]

[ 2019 ]

1

[]

0

null

[ "Eukaryota" ]

[ 2849 ]

1

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)" ]

[ 2, 1, 4, 2, 1, 3, 1 ]

7

true

Domain

WKF domain

WKF

7

IPR019328

19,328

Phosphatidylinositol N-acetylglucosaminyltransferase subunit H, conserved domain

PIGH-H_dom

Domain

3,602

false

This entry represents a conserved domain found in PIG-H proteins. This entry also includes the PIG-H homologues from S. cerevisiae and S. pombe Gpi15 [ ]. Phosphatidylinositol N-acetylglucosaminyltransferase subunit H (PIG-H, also known as Phosphatidylinositol-glycan biosynthesis class H protein) is part of the glycosy...

[]

0

[ "PFAM" ]

[ "PF10181" ]

[ "PIG-H" ]

[ 3602 ]

1

[ "REACTOME", "REACTOME" ]

[ "R-HSA-162710", "R-MMU-162710" ]

[ "REACTOME:R-HSA-162710", "REACTOME:R-MMU-162710" ]

2

[]

0

[ "PUB00019647", "PUB00045077", "PUB00069838", "PUB00098659" ]

[ "11746600", "9463366", "16162815", "19883648" ]

[ "Ynl038wp (Gpi15p) is the Saccharomyces cerevisiae homologue of human Pig-Hp and participates in the first step in glycosylphosphatidylinositol assembly.", "The first step of glycosylphosphatidylinositol biosynthesis is mediated by a complex of PIG-A, PIG-H, PIG-C and GPI1.", "The initial enzyme for glycosylpho...

[ 2001, 1998, 2005, 2010 ]

4

[]

0

null

[ "Eukaryota" ]

[ 3602 ]

1

[ "Arabidopsis thaliana", "Danio rerio", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (st...

[ 4, 1, 8, 2, 1, 6, 7, 1, 1, 7 ]

10

true

Domain

Phosphatidylinositol N-acetylglucosaminyltransferase subunit H, conserved domain

PIGH-H_dom

8

IPR019329

19,329

NADH:ubiquinone oxidoreductase, ESSS subunit

NADH_UbQ_OxRdtase_ESSS_su

Family

2,667

false

Mitochondrial complex I, which is located in the inner mitochondrial membrane, is the largest multimeric respiratory enzyme in the mitochondria, consisting of more than 45 subunits, one FMN co-factor and eight FeS clusters [ ]. The assembly of mitochondrial complex I is an intricate process that requires the cooperatio...

[]

0

[ "PFAM", "PANTHER" ]

[ "PF10183", "PTHR13327" ]

[ "ESSS", "" ]

[ 2653, 1147 ]

2

[ "GP", "GP", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "GenProp1230", "GenProp1637", "R-BTA-611105", "R-BTA-6799198", "R-HSA-611105", "R-HSA-6799198", "R-MMU-611105", "R-MMU-6799198" ]

[ "GP:GenProp1230", "GP:GenProp1637", "REACTOME:R-BTA-611105", "REACTOME:R-BTA-6799198", "REACTOME:R-HSA-611105", "REACTOME:R-HSA-6799198", "REACTOME:R-MMU-611105", "REACTOME:R-MMU-6799198" ]

8

[ "5gup", "5lc5", "5ldw", "5ldx", "5lnk", "5o31", "5xtc", "5xtd", "5xth", "5xti", "6g2j", "6g72", "6q9b", "6qa9", "6qbx", "6qc2", "6qc3", "6qc4", "6qc5", "6qc6", "6qc7", "6qc8", "6qc9", "6qca", "6qcf", "6zka", "6zkb", "6zkc", "6zkd", "6zke", "6zkf", "6zkg"...

214

[ "PUB00005074", "PUB00043561", "PUB00044253", "PUB00045437", "PUB00045438", "PUB00045439" ]

[ "1470679", "10940377", "12381726", "18394423", "18563446", "17854760" ]

[ "The NADH:ubiquinone oxidoreductase (complex I) of respiratory chains.", "The respiratory complex I of bacteria, archaea and eukarya and its module common with membrane-bound multisubunit hydrogenases.", "Definition of the nuclear encoded protein composition of bovine heart mitochondrial complex I. Identificati...

[ 1992, 2000, 2002, 2008, 2008, 2007 ]

6

[]

0

null

[ "Eukaryota" ]

[ 2667 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus" ]

[ 1, 1, 1, 6, 4, 1, 4 ]

7

true

Family

NADH:ubiquinone oxidoreductase, ESSS subunit

NADH_UbQ_OxRdtase_ESSS_su

6

IPR019330

19,330

LRP chaperone MESD

MESD

Family

1,875

false

LRP chaperone MESD (also known as mesoderm development candidate 2) represents a set of highly conserved proteins found from nematodes to humans. It is a chaperone that specifically assists with the folding of β-propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs). It also acts as a modu...

[ "GO:0006457" ]

[ "protein folding" ]

[ "biological_process" ]

1

[ "PFAM", "PANTHER" ]

[ "PF10185", "PTHR17600" ]

[ "Mesd", "" ]

[ 1874, 1592 ]

2

[]

0

[ "2i9s", "2kgl", "2kmi", "2rqk", "2rqm", "3ofe", "3off", "3ofg", "3ofh" ]

9

[ "PUB00044357", "PUB00044358", "PUB00053584" ]

[ "12581524", "17488095", "12581525" ]

[ "Boca, an endoplasmic reticulum protein required for wingless signaling and trafficking of LDL receptor family members in Drosophila.", "Requirement for natively unstructured regions of mesoderm development candidate 2 in promoting low-density lipoprotein receptor-related protein 6 maturation.", "Mesd encodes a...

[ 2003, 2007, 2003 ]

3

[]

0

null

[ "Eukaryota" ]

[ 1875 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 2, 1, 2, 3, 4 ]

6

true

Family

LRP chaperone MESD

MESD

9

IPR019331

19,331

FAM192A/Fyv6, N-terminal

FAM192A/Fyv6_N

Domain

4,071

false

This entry represents the N-terminal domain of the mammalian PIP30/FAM192A protein and the fungal Fyv6 protein. PIP30/FAM192A acts as a regulator of PA28-gamma, a nuclear activator of the 20S proteasome. PIP30 favours PA28-gamma interaction with the 20S proteasome while inhibiting its association with coilin, a central...

[]

0

[ "PFAM" ]

[ "PF10187" ]

[ "FAM192A_Fyv6_N" ]

[ 4071 ]

1

[]

0

[ "7w59", "7w5a", "9dtr" ]

3

[ "PUB00033286", "PUB00044402", "PUB00075469", "PUB00089996", "PUB00158979", "PUB00158980" ]

[ "12663529", "16552446", "12399380", "29934401", "37625852", "38746449" ]

[ "A Saccharomyces cerevisiae genome-wide mutant screen for altered sensitivity to K1 killer toxin.", "Telomere length as a quantitative trait: genome-wide survey and genetic mapping of telomere length-control genes in yeast.", "A genomics-based screen for yeast mutants with an altered recombination/end-joining r...

[ 2003, 2006, 2002, 2018, 2023, 2024 ]

6

[]

0

null

[ "Eukaryota" ]

[ 4071 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 5, 1, 3, 1, 13, 11, 1, 3, 3, 1, 4 ]

11

true

Domain

FAM192A/Fyv6, N-terminal

FAM192A/Fyv6_N

3

IPR019332

19,332

Organic solute carrier protein 1

OSCP1

Family

2,348

false

Organic solute carrier protein 1, or Oscp1, is a family of proteins conserved from plants to humans. It is called organic solute transport protein or oxido-red-nitro domain-containing protein 1, however no reference could be find to confirm the function of the protein.

[]

0

[ "PFAM", "PANTHER" ]

[ "PF10188", "PTHR21439" ]

[ "Oscp1", "" ]

[ 2287, 2331 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Eukaryota" ]

[ 2348 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 2, 10, 4, 3, 6 ]

6

true

Family

Organic solute carrier protein 1

OSCP1

7

IPR019333

19,333

Integrator complex subunit 3, N-terminal

INTS3_N

Domain

2,930

false

This entry represents the N-terminal domain of the Integrator complex subunit 3 (Ints3). The Integrator complex is involved in small nuclear RNA (snRNA) U1 and U2 transcription, and in their 3'-box-dependent processing. This complex associates with the C-terminal domain of RNA polymerase II largest subunit and is recru...

[]

0

[ "PFAM" ]

[ "PF10189" ]

[ "Ints3_N" ]

[ 2930 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-DDI-6807505", "R-DME-6807505", "R-DRE-6807505", "R-HSA-6807505", "R-MMU-6807505" ]

[ "REACTOME:R-DDI-6807505", "REACTOME:R-DME-6807505", "REACTOME:R-DRE-6807505", "REACTOME:R-HSA-6807505", "REACTOME:R-MMU-6807505" ]

5

[ "4owt", "4oww", "4owx", "8rbz" ]

4

[ "PUB00045283", "PUB00098617" ]

[ "16239144", "24630995" ]

[ "Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II.", "Structural basis of SOSS1 complex assembly and recognition of ssDNA." ]

[ 2005, 2014 ]

2

[]

0

null

[ "Eukaryota" ]

[ 2930 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 5, 3, 1, 1, 3, 2, 5, 3, 3 ]

9

true

Domain

Integrator complex subunit 3, N-terminal

INTS3_N

5

IPR019334

19,334

Transmembrane protein 170A/B/YPR153W-like

TMEM170A/B/YPR153W-like

Family

3,611

false

This entry represents a group of transmembrane proteins from animals and fungi, including human Transmembrane protein 170A/B (TMEM170A/B) and YPR153W from Saccharomyces cerevisiae. TMEM170A functions as a regulator of endoplasmic reticulum (ER) and nuclear envelope (NE) morphogenesis. It affects the ratio between tubul...

[]

0

[ "PFAM", "PANTHER" ]

[ "PF10190", "PTHR22779" ]

[ "TMEM170A_B", "" ]

[ 3470, 3516 ]

2

[]

0

[]

0

[ "PUB00147375", "PUB00161092", "PUB00161093" ]

[ "29367600", "26906412", "31797992" ]

[ "Transmembrane protein 170B is a novel breast tumorigenesis suppressor gene that inhibits the Wnt/β-catenin pathway.", "Transmembrane protein TMEM170A is a newly discovered regulator of ER and nuclear envelope morphogenesis in human cells.", "A novel ER membrane protein Ehg1/May24 plays a critical role in maint...

[ 2018, 2016, 2019 ]

3

[]

0

null

[ "Eukaryota" ]

[ 3611 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)" ]

[ 1, 2, 1, 7, 3, 1, 5, 1 ]

8

true

Family

Transmembrane protein 170A/B/YPR153W-like

TMEM170A/B/YPR153W-like

8

IPR019335

19,335

Conserved oligomeric Golgi complex subunit 7

COG7

Family

3,593

false

The conserved oligomeric Golgi (COG) complex is an eight-subunit (Cog1-8) peripheral Golgi protein involved in membrane trafficking and glycoconjugate synthesis [ ]. COG7 is required for normal Golgi morphology and trafficking. Defects in COG7 are the cause of congenital disorder of glycosylation type 2E (CDG2E). CDGs ...

[ "GO:0006886", "GO:0017119" ]

[ "intracellular protein transport", "Golgi transport complex" ]

[ "biological_process", "cellular_component" ]

2

[ "PFAM", "PANTHER" ]

[ "PF10191", "PTHR21443" ]

[ "COG7", "" ]

[ 3410, 3535 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-DDI-6807878", "R-DDI-6811438", "R-DME-6807878", "R-DME-6811438", "R-DME-6811440", "R-HSA-6807878", "R-HSA-6811438", "R-HSA-6811440", "R-MMU-6807878", "R-MMU-6811438", "R-MMU-6811440", "R-RNO-6807878", "R-RNO-6811438", "R-RNO-6811440" ]

[ "REACTOME:R-DDI-6807878", "REACTOME:R-DDI-6811438", "REACTOME:R-DME-6807878", "REACTOME:R-DME-6811438", "REACTOME:R-DME-6811440", "REACTOME:R-HSA-6807878", "REACTOME:R-HSA-6811438", "REACTOME:R-HSA-6811440", "REACTOME:R-MMU-6807878", "REACTOME:R-MMU-6811438", "REACTOME:R-MMU-6811440", "REACTOM...

14

[]

0

[ "PUB00044203", "PUB00045273" ]

[ "15107842", "16051600" ]

[ "Mutation of the COG complex subunit gene COG7 causes a lethal congenital disorder.", "Genetic analysis of the subunit organization and function of the conserved oligomeric golgi (COG) complex: studies of COG5- and COG7-deficient mammalian cells." ]

[ 2004, 2005 ]

2

[]

0

null

[ "Eukaryota" ]

[ 3593 ]

1

[ "Arabidopsis thaliana", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 3, 2, 2, 7, 3, 4, 8, 13 ]

8

true

Family

Conserved oligomeric Golgi complex subunit 7

COG7

2

IPR019337

19,337

Telomere length regulation protein, conserved domain

Telomere_length_regulation_dom

Domain

4,478

false

This entry represents a conserved domain found in a group of proteins called telomere-length regulation TEL2, or clock abnormal protein-2, which are conserved from plants to humans. These proteins regulate telomere length and contribute to silencing of sub-telomeric regions [ ]. Tel2 acts at an early step of the TEL1/A...

[]

0

[ "PFAM" ]

[ "PF10193" ]

[ "Telomere_reg-2" ]

[ 4478 ]

1

[]

0

[ "3o4z", "7f4u" ]

2

[ "PUB00045154", "PUB00088256" ]

[ "11641227", "18334620" ]

[ "The C. elegans maternal-effect gene clk-2 is essential for embryonic development, encodes a protein homologous to yeast Tel2p and affects telomere length.", "Tel2 mediates activation and localization of ATM/Tel1 kinase to a double-strand break." ]

[ 2001, 2008 ]

2

[]

0

null

[ "Eukaryota" ]

[ 4478 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 7, 1, 2, 2, 3, 2, 1, 7, 3, 1, 1, 10 ]

12

true

Domain

Telomere length regulation protein, conserved domain

Telomere_length_regulation_dom

5

IPR019338

19,338

Large ribosomal subunit protein bL35m

Ribosomal_bL35m

Family

1,615

false

This entry represents the large ribosomal subunit protein bL35m from metazoa, which is conserved from nematodes to humans and was previously known as L35 [ ]. This entry represents the large ribosomal subunit protein bL35, previously known as L35, a basic protein of 60 to 70 amino-acid residues [ ]. Like many basic pol...

[]

0

[ "PANTHER" ]

[ "PTHR15909" ]

[ "" ]

[ 1615 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-5389840", "R-BTA-5419276", "R-BTA-9937383", "R-CEL-5389840", "R-CEL-5419276", "R-CEL-9937383", "R-DME-5389840", "R-DME-5419276", "R-DME-9937383", "R-HSA-5368286", "R-HSA-5389840", "R-HSA-5419276", "R-HSA-9937383", "R-MMU-5389840", "R-MMU-5419276", "R-MMU-9937383" ]

[ "REACTOME:R-BTA-5389840", "REACTOME:R-BTA-5419276", "REACTOME:R-BTA-9937383", "REACTOME:R-CEL-5389840", "REACTOME:R-CEL-5419276", "REACTOME:R-CEL-9937383", "REACTOME:R-DME-5389840", "REACTOME:R-DME-5419276", "REACTOME:R-DME-9937383", "REACTOME:R-HSA-5368286", "REACTOME:R-HSA-5389840", "REACTOM...

16

[ "3j7y", "3j9m", "4ce4", "4v19", "5aj4", "5ool", "5oom", "6gaw", "6gb2", "6i9r", "6nu2", "6nu3", "6vlz", "6vmi", "6ydp", "6ydw", "6zm5", "6zm6", "6zs9", "6zsa", "6zsb", "6zsc", "6zsd", "6zse", "6zsg", "7a5f", "7a5g", "7a5h", "7a5i", "7a5j", "7a5k", "7l08"...

88

[ "PUB00000333", "PUB00000584", "PUB00007068", "PUB00007069", "PUB00007070", "PUB00044376" ]

[ "2271612", "3542048", "11297922", "11290319", "11114498", "11551941" ]

[ "Ribosomal protein L35: identification in spinach chloroplasts and isolation of a cDNA clone encoding its cytoplasmic precursor.", "Nonspecific inhibition of Escherichia coli ornithine decarboxylase by various ribosomal proteins: detection of a new ribosomal protein possessing strong antizyme activity.", "Atomi...

[ 1990, 1987, 2001, 2001, 2000, 2001 ]

6

[ "IPR021137" ]

[]

1

0

1

[ "Metazoa" ]

[ 1615 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 1, 1, 3, 1, 7 ]

6

true

Family

Large ribosomal subunit protein bL35m

Ribosomal_bL35m

3

IPR019339

19,339

CBF1-interacting co-repressor CIR, N-terminal domain

CIR_N_dom

Domain

8,614

false

This entry represents a 45 residue conserved domain found at the N-terminal end CIR protein (CBF1-interacting co-repressor, also known as corepressor interacting with RBPJ 1). This domain can be found in the fungal CWC25 family members and mammlian LENG1 (leukocyte receptor cluster member 1) protein. CBF1 (centromere-b...

[]

0

[ "PFAM", "SMART" ]

[ "PF10197", "SM01083" ]

[ "Cir_N", "Cir_N" ]

[ 7303, 8543 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-72163", "R-HSA-72163", "R-MMU-72163", "R-SPO-72163" ]

[ "REACTOME:R-BTA-72163", "REACTOME:R-HSA-72163", "REACTOME:R-MMU-72163", "REACTOME:R-SPO-72163" ]

4

[ "5gmk", "5lj3", "5lj5", "5yzg", "6zym", "7b9v", "8i0w" ]

7

[ "PUB00019458", "PUB00044199", "PUB00075502" ]

[ "14690591", "9874765", "15652350" ]

[ "Assigning function to yeast proteins by integration of technologies.", "CIR, a corepressor linking the DNA binding factor CBF1 to the histone deacetylase complex.", "CIR, a corepressor of CBF1, binds to PAP-1 and effects alternative splicing." ]

[ 2003, 1999, 2005 ]

3

[]

0

null

[ "Eukaryota" ]

[ 8614 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 17, 2, 3, 7, 5, 5, 2, 11, 7, 1, 1, 12 ]

12

true

Domain

CBF1-interacting co-repressor CIR, N-terminal domain

CIR_N_dom

1

IPR019340

19,340

Histone acetyltransferases subunit 3

Histone_AcTrfase_su3

Family

4,102

false

This entry is found in Ada3 and homologous proteins which function as part of histone acetyltransferase complexes [ ]. Ada3 is an essential component of the Ada transcriptional coactivator (alteration/deficiency in activation) complex. It plays a key role in linking histone acetyltransferase-containing complexes to p53...

[]

0

[ "PFAM", "PANTHER" ]

[ "PF10198", "PTHR13556" ]

[ "Ada3", "" ]

[ 3820, 3521 ]

2

[ "GP", "GP", "GP", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "GenProp2053", "GenProp2055", "GenProp2057", "R-BTA-5689880", "R-BTA-9772755", "R-DRE-5689880", "R-HSA-3214847", "R-HSA-5689880", "R-HSA-9772755", "R-MMU-5689880", "R-MMU-9772755", "R-RNO-5689880", "R-RNO-9772755", "R-SCE-5689880", "R-SPO-5689880", "R-XTR-5689880" ]

[ "GP:GenProp2053", "GP:GenProp2055", "GP:GenProp2057", "REACTOME:R-BTA-5689880", "REACTOME:R-BTA-9772755", "REACTOME:R-DRE-5689880", "REACTOME:R-HSA-3214847", "REACTOME:R-HSA-5689880", "REACTOME:R-HSA-9772755", "REACTOME:R-MMU-5689880", "REACTOME:R-MMU-9772755", "REACTOME:R-RNO-5689880", "REA...

16

[ "6tbm" ]

1

[ "PUB00044135", "PUB00044136" ]

[ "8413201", "17272277" ]

[ "ADA3: a gene, identified by resistance to GAL4-VP16, with properties similar to and different from those of ADA2.", "An essential role of human Ada3 in p53 acetylation." ]

[ 1993, 2007 ]

2

[]

0

null

[ "Bacteria", "Eukaryota" ]

[ 2, 4100 ]

2

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe ...

[ 3, 3, 4, 3, 1, 1, 6, 1, 1, 9 ]

10

true

Family

Histone acetyltransferases subunit 3

Histone_AcTrfase_su3

4

IPR019341

19,341

Alpha/gamma-adaptin-binding protein p34

Alpha/Gamma-adaptin-bd_p34

Family

3,012

false

Alpha- and gamma-adaptin-binding protein p34 is a protein involved in membrane trafficking. It is known to interact with both alpha and gamma adaptin [ ]. It has been speculated that p34 may play a chaperone role such as preventing the soluble adaptors from co-assembling with soluble clathrin, or helping to remove the ...

[]

0

[ "PANTHER" ]

[ "PTHR14659" ]

[ "" ]

[ 3012 ]

1

[]

0

[ "7twd", "9dds", "9ddt" ]

3

[ "PUB00044137" ]

[ "10477754" ]

[ "Gamma-synergin: an EH domain-containing protein that interacts with gamma-adaptin." ]

[ 1999 ]

1

[]

0

null

[ "Eukaryota" ]

[ 3012 ]

1

[ "Arabidopsis thaliana", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 5, 1, 1, 4, 2, 1, 3, 3, 8 ]

9

true

Family

Alpha/gamma-adaptin-binding protein p34

Alpha/Gamma-adaptin-bd_p34

1

IPR019342

19,342

NADH:ubiquinone oxidoreductase, iron-sulphur subunit 5

NADH_UbQ_OxRdtase_FeS-su5

Family

3,457

false

Proteins in this entry form part of the NADH:ubiquinone oxidoreductase complex I. Complex I is the first multisubunit inner membrane protein complex of the mitochondrial electron transport chain and it transfers two electrons from NADH to ubiquinone. The mammalian complex I is composed of 45 different subunits. The pro...

[]

0

[ "PFAM", "PANTHER" ]

[ "PF10200", "PTHR15224" ]

[ "Ndufs5", "" ]

[ 2238, 2866 ]

2

[ "GP", "GP", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "GenProp1230", "GenProp1637", "R-BTA-611105", "R-BTA-6799198", "R-HSA-611105", "R-HSA-6799198", "R-MMU-611105", "R-MMU-6799198" ]

[ "GP:GenProp1230", "GP:GenProp1637", "REACTOME:R-BTA-611105", "REACTOME:R-BTA-6799198", "REACTOME:R-HSA-611105", "REACTOME:R-HSA-6799198", "REACTOME:R-MMU-611105", "REACTOME:R-MMU-6799198" ]

8

[ "5gpn", "5gup", "5lc5", "5ldw", "5ldx", "5lnk", "5o31", "5xtc", "5xtd", "5xth", "5xti", "6g2j", "6g72", "6gcs", "6q9b", "6qa9", "6qbx", "6qc2", "6qc3", "6qc4", "6qc5", "6qc6", "6qc7", "6qc8", "6qc9", "6qca", "6qcf", "6rfq", "6rfr", "6rfs", "6y79", "6yj4"...

241

[ "PUB00044394" ]

[ "10070614" ]

[ "The human NADH: ubiquinone oxidoreductase NDUFS5 (15 kDa) subunit: cDNA cloning, chromosomal localization, tissue distribution and the absence of mutations in isolated complex I-deficient patients." ]

[ 1999 ]

1

[]

0

null

[ "Eukaryota" ]

[ 3457 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 9, 1, 1, 2, 2, 3, 1, 2, 3, 2 ]

10

true

Family

NADH:ubiquinone oxidoreductase, iron-sulphur subunit 5

NADH_UbQ_OxRdtase_FeS-su5

9

IPR019343

19,343

Protein phosphatase 1 regulatory subunit 21, N-terminal

PPP1R21_N

Domain

2,201

false

This entry represents a N-terminal 100 residues long domain found in Protein phosphatase 1 regulatory subunit 21, which contains a conserved KLRAQ motif. This domain is found in a family of coiled-coil domain-containing proteins that are conserved from nematodes to humans. These proteins also contain a C-terminal TTKRS...

[]

0

[ "PFAM", "SMART" ]

[ "PF10205", "SM01254" ]

[ "KLRAQ", "KLRAQ" ]

[ 2139, 2168 ]

2

[]

0

[ "7nd2" ]

1

[ "PUB00060082", "PUB00101818" ]

[ "19389623", "30520571" ]

[ "Docking motif-guided mapping of the interactome of protein phosphatase-1.", "Biallelic loss of function variants in PPP1R21 cause a neurodevelopmental syndrome with impaired endocytic function." ]

[ 2009, 2019 ]

2

[]

0

null

[ "Eukaryota" ]

[ 2201 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 7, 1, 4, 1, 4 ]

6

true

Domain

Protein phosphatase 1 regulatory subunit 21, N-terminal

PPP1R21_N

7

IPR019344

19,344

Mitochondrial F1-F0 ATP synthase subunit F, predicted

F1F0-ATPsyn_F_prd

Family

2,588

false

This entry represents small proteins of approximately 110 amino acids, which are highly conserved from nematodes to humans. Some have been annotated in Swiss-Prot as being the f subunit of mitochondrial F1F0-ATP synthase but this could not be confirmed. The sequence has a well-conserved WRW motif. The exact function of...

[]

0

[ "PFAM", "PANTHER" ]

[ "PF10206", "PTHR13080" ]

[ "WRW", "" ]

[ 2482, 2224 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-163210", "R-BTA-8949613", "R-CEL-163210", "R-CEL-8949613", "R-DME-163210", "R-DME-8949613", "R-HSA-163210", "R-HSA-8949613", "R-MMU-163210", "R-MMU-8949613", "R-RNO-163210", "R-RNO-8949613", "R-SSC-163210", "R-SSC-8949613" ]

[ "REACTOME:R-BTA-163210", "REACTOME:R-BTA-8949613", "REACTOME:R-CEL-163210", "REACTOME:R-CEL-8949613", "REACTOME:R-DME-163210", "REACTOME:R-DME-8949613", "REACTOME:R-HSA-163210", "REACTOME:R-HSA-8949613", "REACTOME:R-MMU-163210", "REACTOME:R-MMU-8949613", "REACTOME:R-RNO-163210", "REACTOME:R-RN...

14

[ "6j54", "6j5a", "6j5i", "6j5j", "6j5k", "6tt7", "6za9", "6zbb", "6ziq", "6zit", "6ziu", "6zmr", "6zna", "6zpo", "6zqm", "6zqn", "7ajb", "7ajc", "7ajd", "7aje", "7ajf", "7ajg", "7ajh", "7aji", "7ajj", "8h9f", "8h9j", "8h9m", "8h9q", "8h9s", "8h9t", "8h9u"...

40

[]

0

[]

0

null

[ "Bacteria", "Eukaryota" ]

[ 2, 2586 ]

2

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 6, 2, 4, 2, 5 ]

6

true

Family

Mitochondrial F1-F0 ATP synthase subunit F, predicted

F1F0-ATPsyn_F_prd

2

IPR019345

19,345

ARMET, C-terminal

ARMET_C

Domain

2,285

false

This entry represents the C-terminal domain of ARMET. ARMET, also known as mesencephalic astrocyte-derived neurotrophic factor (MANF) or arginine-rich protein, is a small protein of approximately 170 residues which contains four di-sulphide bridges that are highly conserved from nematodes to humans. It is a soluble pro...

[]

0

[ "PFAM" ]

[ "PF10208" ]

[ "ARMET_C" ]

[ 2285 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-114608", "R-CEL-114608", "R-DME-114608", "R-HSA-114608", "R-MMU-114608", "R-RNO-114608" ]

[ "REACTOME:R-BTA-114608", "REACTOME:R-CEL-114608", "REACTOME:R-DME-114608", "REACTOME:R-HSA-114608", "REACTOME:R-MMU-114608", "REACTOME:R-RNO-114608" ]

6

[ "2kvd", "2kve", "2rqy", "2w51", "4bit", "6h9u", "6ha7", "8qaj", "9h0c" ]

9

[ "PUB00044154", "PUB00045443", "PUB00089656" ]

[ "17507765", "16462600", "27425895" ]

[ "ARMET is a soluble ER protein induced by the unfolded protein response via ERSE-II element.", "Mesencephalic astrocyte-derived neurotrophic factor enhances nigral gamma-aminobutyric acid release.", "Unconventional neurotrophic factors CDNF and MANF: Structure, physiological functions and therapeutic potential....

[ 2007, 2006, 2017 ]

3

[]

0

null

[ "Eukaryota" ]

[ 2285 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 2, 1, 3, 4, 7 ]

6

true

Domain

ARMET, C-terminal

ARMET_C

6

IPR019346

19,346

Large ribosomal subunit protein mL42

Ribosomal_mL42

Family

1,664

false

This entry represents a family of short proteins; each approximately 100 amino acid residues in length. They are identified as the large ribosomal subunit protein mL42, also known as mitochondrial 39S ribosomal protein L42.

[]

0

[ "PFAM", "PANTHER" ]

[ "PF10210", "PTHR13450" ]

[ "MRP-S32", "" ]

[ 1655, 1540 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-5389840", "R-BTA-5419276", "R-BTA-9937383", "R-HSA-5368286", "R-HSA-5389840", "R-HSA-5419276", "R-HSA-9937383", "R-MMU-5389840", "R-MMU-5419276", "R-MMU-9937383", "R-RNO-5389840", "R-RNO-5419276", "R-RNO-9937383" ]

[ "REACTOME:R-BTA-5389840", "REACTOME:R-BTA-5419276", "REACTOME:R-BTA-9937383", "REACTOME:R-HSA-5368286", "REACTOME:R-HSA-5389840", "REACTOME:R-HSA-5419276", "REACTOME:R-HSA-9937383", "REACTOME:R-MMU-5389840", "REACTOME:R-MMU-5419276", "REACTOME:R-MMU-9937383", "REACTOME:R-RNO-5389840", "REACTOM...

13

[ "3j7y", "3j9m", "4v1a", "5aj4", "5ool", "5oom", "6gaw", "6gb2", "6i9r", "6nu2", "6nu3", "6vlz", "6vmi", "6ydp", "6ydw", "6zm5", "6zm6", "6zs9", "6zsa", "6zsb", "6zsc", "6zsd", "6zse", "6zsg", "7a5f", "7a5g", "7a5h", "7a5i", "7a5j", "7a5k", "7l08", "7l20"...

90

[]

0

[]

0

null

[ "Eumetazoa" ]

[ 1664 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 1, 1, 5, 3, 12 ]

6

true

Family

Large ribosomal subunit protein mL42

Ribosomal_mL42

3

IPR019347

19,347

Axonemal dynein light chain

Axonemal_dynein_light_chain

Family

3,820

false

Axonemal dynein light chain proteins play a dynamic role in flagellar and cilial motility. Eukaryotic cilia and flagella are complex organelles consisting of a core structure, the axoneme, which is composed of nine microtubule doublets forming a cylinder that surrounds a pair of central singlet microtubules. This ultra...

[]

0

[ "PFAM", "PANTHER" ]

[ "PF10211", "PTHR13183" ]

[ "Ax_dynein_light", "" ]

[ 3818, 2678 ]

2

[]

0

[ "7ju4", "8glv", "8j07", "9d2f", "9e5c", "9fqr" ]

6

[ "PUB00044164" ]

[ "11606062" ]

[ "Association between actin and light chains in Chlamydomonas flagellar inner-arm dyneins." ]

[ 2001 ]

1

[]

0

null

[ "Bacteria", "Eukaryota" ]

[ 9, 3811 ]

2

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 2, 2, 8, 7, 4 ]

6

true

Family

Axonemal dynein light chain

Axonemal_dynein_light_chain

1

IPR019348

19,348

Protein phosphatase 1 regulatory subunit 21, six-helix bundle

PPP1R21_six_helix

Domain

1,614

false

This entry represents a middle domain found between the N- and C-terminal coiled-coil regions of PPP1R21. According to structure predictions, it appears to form a six-helix bundle, which contains a conserved TTKRSYEDQ motif. Protein phosphatase 1 regulatory subunit 21 (PPP1R21) belong to a family of coiled-coil domain-...

[]

0

[ "PFAM" ]

[ "PF10212" ]

[ "PPP1R21_helical" ]

[ 1614 ]

1

[]

0

[ "7nd2" ]

1

[ "PUB00060082", "PUB00101818" ]

[ "19389623", "30520571" ]

[ "Docking motif-guided mapping of the interactome of protein phosphatase-1.", "Biallelic loss of function variants in PPP1R21 cause a neurodevelopmental syndrome with impaired endocytic function." ]

[ 2009, 2019 ]

2

[]

0

null

[ "Eukaryota", "Neisseria montereyensis" ]

[ 1613, 1 ]

2

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 8, 2, 1, 3 ]

4

true

Domain

Protein phosphatase 1 regulatory subunit 21, six-helix bundle

PPP1R21_six_helix

7

IPR019349

19,349

Small ribosomal subunit protein mS35, mitochondrial, conserved domain

Ribosomal_mS35_mit

Domain

4,173

false

This entry represents a conserved region of approx. 125 residues of one of the small ribosomal subunit protein mS35 of the mitochondrial ribosome. In Saccharomyces cerevisiae (baker's yeast) it was known as mitochondrial ribosomal protein S24 whereas in humans was S35. Ribosomes are the particles that catalyse mRNA-dir...

[]

0

[ "PFAM" ]

[ "PF10213" ]

[ "MRP-S28" ]

[ 4173 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-5389840", "R-BTA-5419276", "R-BTA-9937383", "R-DRE-5389840", "R-DRE-5419276", "R-HSA-5368286", "R-HSA-5389840", "R-HSA-5419276", "R-HSA-9937383", "R-MMU-5389840", "R-MMU-5419276", "R-MMU-9937383" ]

[ "REACTOME:R-BTA-5389840", "REACTOME:R-BTA-5419276", "REACTOME:R-BTA-9937383", "REACTOME:R-DRE-5389840", "REACTOME:R-DRE-5419276", "REACTOME:R-HSA-5368286", "REACTOME:R-HSA-5389840", "REACTOME:R-HSA-5419276", "REACTOME:R-HSA-9937383", "REACTOME:R-MMU-5389840", "REACTOME:R-MMU-5419276", "REACTOM...

12

[ "3j9m", "3jd5", "5aj3", "5aj4", "5mrc", "5mre", "5mrf", "6gaw", "6gaz", "6neq", "6nf8", "6nu2", "6nu3", "6rw4", "6rw5", "6vlz", "6vmi", "6xyw", "6ydp", "6ydw", "6yw5", "6ywe", "6ywx", "6ywy", "6z1p", "6zm5", "6zm6", "6zs9", "6zsa", "6zsb", "6zsc", "6zsd"...

98

[ "PUB00007068", "PUB00007069", "PUB00007070" ]

[ "11297922", "11290319", "11114498" ]

[ "Atomic structures at last: the ribosome in 2000.", "The ribosome in focus.", "The end of the beginning: structural studies of ribosomal proteins." ]

[ 2001, 2001, 2000 ]

3

[]

0

null

[ "Eukaryota" ]

[ 4173 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 10, 2, 1, 1, 1, 2, 1, 2, 4, 1, 1, 2 ]

12

true

Domain

Small ribosomal subunit protein mS35, mitochondrial, conserved domain

Ribosomal_mS35_mit

7

IPR019351

19,351

Protein of unknown function DUF2039

DUF2039

Family

2,063

false

This entry is a region of approximately 100 residues containing three pairs of cysteine residues. The region is conserved from plants to humans but its function is unknown.

[]

0

[ "PFAM", "PANTHER" ]

[ "PF10217", "PTHR22876" ]

[ "DUF2039", "" ]

[ 2048, 2022 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Eukaryota" ]

[ 2063 ]

1

[ "Arabidopsis thaliana", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 4, 1, 2, 2, 2, 2, 3, 4 ]

8

true

Family

Protein of unknown function DUF2039

DUF2039

3

IPR019352

19,352

SREBP regulating gene protein

SPRING1

Family

2,445

false

SPRING1 is a glycosylated Golgi-resident membrane protein involved in SREBP signaling and cholesterol metabolism. It modulates the proper localization of SCAP (SREBP cleavage-activating protein) to the endoplasmic reticulum, thereby controlling the level of functional SCAP [ ].

[ "GO:2000640" ]

[ "positive regulation of SREBP signaling pathway" ]

[ "biological_process" ]

1

[ "PFAM", "PANTHER" ]

[ "PF10218", "PTHR13481" ]

[ "SPRING1", "" ]

[ 2444, 2400 ]

2

[]

0

[ "8uw8", "9csd" ]

2

[ "PUB00094523" ]

[ "32111832" ]

[ "Haploid genetic screens identify SPRING/C12ORF49 as a determinant of SREBP signaling and cholesterol metabolism." ]

[ 2020 ]

1

[]

0

null

[ "Eukaryota" ]

[ 2445 ]

1

[ "Arabidopsis thaliana", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 6, 2, 1, 3, 1, 5, 3, 5 ]

8

true

Family

SREBP regulating gene protein

SPRING1

6

IPR019354

19,354

Nonsense-mediated mRNA decay factor SMG8-like

SMG8-like

Family

2,878

false

This entry represents human SMG8 and similar eukaryotic proteins. SMG8 is a subunit of the Smg-1 complex that suppress Smg-1 kinase activity in the isolated Smg-1 complex, and is involved in nonsense-mediated mRNA decay (NMD) in both mammals and nematodes [ ]. NMD is a surveillance mechanism that detects and degrades m...

[ "GO:0000184" ]

[ "nuclear-transcribed mRNA catabolic process, nonsense-mediated decay" ]

[ "biological_process" ]

1

[ "PFAM", "PANTHER" ]

[ "PF10220", "PTHR13091" ]

[ "Smg8_Smg9", "" ]

[ 2750, 2649 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-975957", "R-CEL-975957", "R-DME-975957", "R-HSA-975957", "R-MMU-975957", "R-XTR-975957" ]

[ "REACTOME:R-BTA-975957", "REACTOME:R-CEL-975957", "REACTOME:R-DME-975957", "REACTOME:R-HSA-975957", "REACTOME:R-MMU-975957", "REACTOME:R-XTR-975957" ]

6

[ "5nkk", "5nkm", "6l54", "6syt", "6z3r", "7pw4", "7pw5", "7pw8" ]

8

[ "PUB00054170" ]

[ "19417104" ]

[ "SMG-8 and SMG-9, two novel subunits of the SMG-1 complex, regulate remodeling of the mRNA surveillance complex during nonsense-mediated mRNA decay." ]

[ 2009 ]

1

[]

0

null

[ "Eukaryota" ]

[ 2878 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 3, 2, 1, 4, 2, 4, 2, 10 ]

8

true

Family

Nonsense-mediated mRNA decay factor SMG8-like

SMG8-like

4