interpro_id string | interpro_numeric_id int64 | name string | short_name string | entry_type string | protein_count int64 | is_llm bool | is_llm_reviewed bool | abstract string | go_ids list | go_terms list | go_categories list | go_count int64 | member_databases list | member_accessions list | member_names list | member_protein_counts list | member_count int64 | external_databases list | external_accessions list | external_xrefs list | external_xref_count int64 | pdb_ids list | structure_count int64 | publication_ids list | pubmed_ids list | publication_titles list | publication_years list | publication_count int64 | parent_ids list | child_ids list | parent_count int64 | child_count int64 | tree_depth float64 | taxonomy_names list | taxonomy_protein_counts list | taxonomy_count int64 | key_species_names list | key_species_protein_counts list | key_species_count int64 | in_entry_list bool | entry_list_type string | entry_list_name string | names_dat_name string | short_names_dat_name string | split_bucket int64 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
IPR018830 | 18,830 | Protein of unknown function DUF2434 | DUF2434 | Family | 765 | false | false | This entry represents a family of proteins conserved in fungi. Their function is not known. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF10361"
] | [
"DUF2434"
] | [
765
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Opisthokonta"
] | [
765
] | 1 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
1,
1
] | 2 | true | Family | Protein of unknown function DUF2434 | Protein of unknown function DUF2434 | DUF2434 | 4 |
IPR018831 | 18,831 | Uncharacterised protein family NKWYS | Uncharacterised_NKWYS | Family | 240 | false | false | This entry contains proteins of no known function. They are found predominantly in bacterial species and are characterised by having a NKWYS sequence motif. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF10364"
] | [
"NKWYS"
] | [
240
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"ecological metagenomes"
] | [
236,
4
] | 2 | [] | [] | 0 | true | Family | Uncharacterised protein family NKWYS | Uncharacterised protein family NKWYS | Uncharacterised_NKWYS | 4 |
IPR018832 | 18,832 | Peptidase C25, gingipain, C-terminal | Pept_C25_gingipain_C | Domain | 83 | false | false | Gingipains R and K are endopeptidases with specificity for arginyl and lysyl bonds, respectively. Like other cysteine peptidases, they require reducing conditions for activity. They are maximally active at approximately neutral pH. Gingipains R and K are secreted by the bacterium Porphyromonas gingivalis (Bacteroides g... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF10365"
] | [
"DUF2436"
] | [
83
] | 1 | [] | [] | [] | 0 | [
"9isp"
] | 1 | [
"PUB00044887"
] | [
"10064139"
] | [
"Activation of protein C by arginine-specific cysteine proteinases (gingipains-R) from Porphyromonas gingivalis."
] | [
1999
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"bioreactor metagenome"
] | [
82,
1
] | 2 | [] | [] | 0 | true | Domain | Peptidase C25, gingipain, C-terminal | Peptidase C25, gingipain, C-terminal | Pept_C25_gingipain_C | 7 |
IPR018833 | 18,833 | Rv2993c-like, N-terminal | Rv2993c-like_N | Domain | 8,236 | false | false | This entry represents the N-terminal 50 amino acids of a group of bacterial proteins, including protein Rv2993c from Mycobacterium tuberculosis. Some members of this entry are annotated as fumarylacetoacetate hydrolase-containing enzymes. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF10370"
] | [
"Rv2993c-like_N"
] | [
8236
] | 1 | [] | [] | [] | 0 | [
"2dfu",
"3qdf",
"3rr6",
"4dbf",
"4dbh",
"4pfz"
] | 6 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
82,
7881,
53,
220
] | 4 | [] | [] | 0 | true | Domain | Rv2993c-like, N-terminal | Rv2993c-like, N-terminal | Rv2993c-like_N | 6 |
IPR018834 | 18,834 | DNA/RNA-binding domain, Est1-type | DNA/RNA-bd_Est1-type | Domain | 11,925 | false | false | This entry represents a DNA/RNA binding domain found in the telomere elongation protein EST1 and related sequences, such as the nonsense-mediated mRNA decay pathway proteins SMG5 and SMG7 [ , , , ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF10373"
] | [
"EST1_DNA_bind"
] | [
11925
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-DRE-975957",
"R-HSA-975957",
"R-MMU-975957",
"R-SCE-975957",
"R-SPO-975957"
] | [
"REACTOME:R-DRE-975957",
"REACTOME:R-HSA-975957",
"REACTOME:R-MMU-975957",
"REACTOME:R-SCE-975957",
"REACTOME:R-SPO-975957"
] | 5 | [
"1ya0",
"3zhe",
"4um2",
"5y5a",
"8bh8",
"8bh9",
"9qdq"
] | 7 | [
"PUB00044256",
"PUB00057242",
"PUB00057243",
"PUB00101150"
] | [
"12676088",
"14636577",
"15546618",
"25013172"
] | [
"Telomere maintenance in fission yeast requires an Est1 ortholog.",
"Phosphorylation of hUPF1 induces formation of mRNA surveillance complexes containing hSMG-5 and hSMG-7.",
"SMG7 acts as a molecular link between mRNA surveillance and mRNA decay.",
"Phospho-dependent and phospho-independent interactions of t... | [
2003,
2003,
2004,
2014
] | 4 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Pseudomonadati",
"marine sediment metagenome"
] | [
11853,
71,
1
] | 3 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
10,
3,
5,
5,
19,
10,
2,
7,
16,
2,
2,
15
] | 12 | true | Domain | DNA/RNA-binding domain, Est1-type | DNA/RNA-binding domain, Est1-type | DNA/RNA-bd_Est1-type | 9 |
IPR018835 | 18,835 | RNA-binding domain, putative | RNA-binding_domain_put | Domain | 1,066 | false | false | This entry represents a putative RNA-binding domain found only in fungi. It occurs in proteins annotated as Nrd1, which are known to carry RNA recogntion motif (RRM) domains. It is not homologous with any of the other RRM domains, e.g. . | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF10378"
] | [
"RRM"
] | [
1066
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Pseudomonadota"
] | [
1064,
2
] | 2 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)"
] | [
1,
1
] | 2 | true | Domain | RNA-binding domain, putative | RNA-binding domain, putative | RNA-binding_domain_put | 9 |
IPR018836 | 18,836 | Necrogenic protein Nec1 | Necrogenic_Nec1 | Family | 39 | false | false | The Nec1 protein has necrogenic activity on excised potato tuber tissue, and the encoding gene is highly conserved in plant-pathogenic Streptomyces spp. The G+C content of nec1 indicates lateral transfer from an unrelated taxon, but its origins are unclear. Deletion analysis of nec1 demonstrated that the 151-amino-acid... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF10379"
] | [
"nec1"
] | [
39
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00054158"
] | [
"17555268"
] | [
"Streptomyces turgidiscabies secretes a novel virulence protein, Nec1, which facilitates infection."
] | [
2007
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria"
] | [
39
] | 1 | [] | [] | 0 | true | Family | Necrogenic protein Nec1 | Necrogenic protein Nec1 | Necrogenic_Nec1 | 6 |
IPR018837 | 18,837 | Transcription factor CRF1/IFH1 | TF_CRF1/IFH1 | Family | 209 | false | false | CRF1 and IFH1 are transcription factors that control ribosomal gene regulation in S. cerevisiae. CRF1 binds FHL1 via the TOR signalling pathway and protein kinase A, and co-represses ribosomal genes [ ]. Contrarily, IFH1 binds FHL1 under rich growth conditions and induces ribosomal protein expression [ , ]. CRF1 and IF... | [
"GO:0003712",
"GO:0060962"
] | [
"transcription coregulator activity",
"regulation of ribosomal protein gene transcription by RNA polymerase II"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PFAM",
"PANTHER"
] | [
"PF10380",
"PTHR28057"
] | [
"CRF1",
""
] | [
200,
199
] | 2 | [] | [] | [] | 0 | [] | 0 | [
"PUB00044214",
"PUB00074999",
"PUB00075000",
"PUB00075001"
] | [
"15620355",
"20212107",
"15616569",
"15616568"
] | [
"TOR regulates ribosomal protein gene expression via PKA and the Forkhead transcription factor FHL1.",
"Gene duplication and the evolution of ribosomal protein gene regulation in yeast.",
"Growth-regulated recruitment of the essential yeast ribosomal protein gene activator Ifh1.",
"The transcription factor If... | [
2004,
2010,
2004,
2004
] | 4 | [] | [] | 0 | 0 | null | [
"Dikarya"
] | [
209
] | 1 | [
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
2,
1
] | 2 | true | Family | Transcription factor CRF1/IFH1 | Transcription factor CRF1/IFH1 | TF_CRF1/IFH1 | 2 |
IPR018838 | 18,838 | 5'-3' DNA helicase ZGRF1-like, N-terminal domain | ZGRF1-like_N | Domain | 3,169 | false | false | This domain can be found at the N-terminal end of human 5'-3' DNA helicase ZGRF1 and similar eukaryotic proteins. ZGRF1 promotes repair of replication-blocking DNA lesions through stimulation of homologous recombination (HR) [ , ]. This domain can also be found in Mte1 (Mph1-associated telomere maintenance protein 1) f... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF10382"
] | [
"ZGRF1-like_N"
] | [
3169
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00044234",
"PUB00044235",
"PUB00089971",
"PUB00098331",
"PUB00101195",
"PUB00101196",
"PUB00153163"
] | [
"15161972",
"16169489",
"26920759",
"32640219",
"26966246",
"26966248",
"34552057"
] | [
"A genome-wide screen for Saccharomyces cerevisiae deletion mutants that affect telomere length.",
"Novel genes required for meiotic chromosome segregation are identified by a high-throughput knockout screen in fission yeast.",
"MTE1 Functions with MPH1 in Double-Strand Break Repair.",
"The ZGRF1 Helicase Pro... | [
2004,
2005,
2016,
2020,
2016,
2016,
2021
] | 7 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
3169
] | 1 | [
"Arabidopsis thaliana",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyc... | [
6,
1,
5,
3,
1,
3,
5,
1,
1
] | 9 | true | Domain | 5'-3' DNA helicase ZGRF1-like, N-terminal domain | 5'-3' DNA helicase ZGRF1-like, N-terminal domain | ZGRF1-like_N | 7 |
IPR018839 | 18,839 | Cryptic loci regulator 2, C-terminal | Tscrpt-silencing_Clr2_C | Domain | 1,519 | false | false | Clr2 (cryptic loci regulator) is a chromatin silencing protein, one of a quartet of proteins forming the core of SHREC, a multienzyme effector complex that mediates hetero-chromatic transcriptional gene silencing in fission yeast [ ]. Clr2 does not have any obvious well-conserved domains, but along with the other core ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF10383"
] | [
"Clr2"
] | [
1519
] | 1 | [] | [] | [] | 0 | [
"5ikj"
] | 1 | [
"PUB00044886"
] | [
"17289569"
] | [
"SHREC, an effector complex for heterochromatic transcriptional silencing."
] | [
2007
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1519
] | 1 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
1,
1
] | 2 | true | Domain | Cryptic loci regulator 2, C-terminal | Cryptic loci regulator 2, C-terminal | Tscrpt-silencing_Clr2_C | 2 |
IPR018840 | 18,840 | Protein of unknown function DUF2441 | DUF2441 | Family | 644 | false | false | This is a family of highly conserved predicted proteins primarily found in Bacillus species. Structurally they form homo-dimers, but their function is unknown. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF10386"
] | [
"DUF2441"
] | [
644
] | 1 | [] | [] | [] | 0 | [
"2aua"
] | 1 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Rhizophagus irregularis (strain DAOM 197198w)",
"Viruses",
"metagenomes"
] | [
3,
629,
1,
4,
7
] | 5 | [] | [] | 0 | true | Family | Protein of unknown function DUF2441 | Protein of unknown function DUF2441 | DUF2441 | 4 |
IPR018841 | 18,841 | Protein of unknown function DUF2442 | DUF2442 | Family | 6,140 | false | false | Several proteins in this family are annotated as being putative molybdopterin-guanine dinucleotide biosynthesis proteins, but this has not been confirmed. Members of this family also include proteins containing the N-terminal domain of the bacteria NE0471 protein. The function of these proteins is not known. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF10387"
] | [
"DUF2442"
] | [
6140
] | 1 | [] | [] | [] | 0 | [
"2auw",
"2x8n",
"3k8r"
] | 3 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"unclassified Caudoviricetes",
"unclassified sequences"
] | [
5987,
13,
7,
133
] | 4 | [] | [] | 0 | true | Family | Protein of unknown function DUF2442 | Protein of unknown function DUF2442 | DUF2442 | 8 |
IPR018842 | 18,842 | YkuI, C-terminal | YkuI_C | Domain | 1,667 | false | false | In most cases this highly conserved region of the YkuI protein lies immediately downstream of the EAL (diguanylate cyclase/phosphodiesterase) domain so that together they form a monomer which dimerises for its enzymatic action. This region contains three α helices and five β strands and forms C-terminal half of the str... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF10388"
] | [
"YkuI_C"
] | [
1667
] | 1 | [] | [] | [] | 0 | [
"2bas",
"2w27"
] | 2 | [
"PUB00050011"
] | [
"19244251"
] | [
"Crystal structures of YkuI and its complex with second messenger cyclic Di-GMP suggest catalytic mechanism of phosphodiester bond cleavage by EAL domains."
] | [
2009
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"marine sediment metagenome"
] | [
1665,
2
] | 2 | [] | [] | 0 | true | Domain | YkuI, C-terminal | YkuI, C-terminal | YkuI_C | 1 |
IPR018843 | 18,843 | Utp8, beta-propeller | Utp8_b-prop | Domain | 983 | false | false | This entry represents the N-terminal β-propeller of U3 small nucleolar RNA-associated protein 8 from Saccharomyces cerevisiae (Utp8) and similar proteins mainly found in ascomycetes. Utp8 is an essential component of the nuclear tRNA export machinery in S. cerevisiae. It is a tRNA-binding protein that acts at a step be... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF10395"
] | [
"Utp8_b_propeller"
] | [
983
] | 1 | [] | [] | [] | 0 | [
"6ke6",
"6lqp",
"6lqq",
"6lqr",
"6lqs",
"6lqu",
"6lqv",
"6zqa",
"6zqb",
"6zqc",
"6zqd",
"6zqe",
"7ajt",
"7aju",
"7d4i",
"7d5s",
"7d63",
"7suk",
"9g33",
"9n6v",
"9n6w",
"9n6x",
"9n6y",
"9n6z",
"9n70",
"9n72",
"9n73",
"9n74",
"9n75",
"9n76",
"9n77",
"9n78"... | 32 | [
"PUB00008496",
"PUB00044528"
] | [
"12068309",
"17634288"
] | [
"A large nucleolar U3 ribonucleoprotein required for 18S ribosomal RNA biogenesis.",
"Utp8p is a nucleolar tRNA-binding protein that forms a complex with components of the nuclear tRNA export machinery in Saccharomyces cerevisiae."
] | [
2002,
2007
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
983
] | 1 | [
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
1,
1
] | 2 | true | Domain | Utp8, beta-propeller | Utp8, beta-propeller | Utp8_b-prop | 5 |
IPR018844 | 18,844 | Nucleolar protein Dnt1-like, N-terminal | Dnt1-like_N | Domain | 472 | false | false | Cytokinesis in yeasts involves a family of proteins whose essential function is to bind Cdc14-family phosphatase and prevent this from being sequestered and inhibited in the nucleolus. This is the highly conserved N terminus of a family of proteins which act as cytokinesis checkpoint controls by allowing cells to cope ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF10407"
] | [
"Cytokin_check_N"
] | [
472
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00044221"
] | [
"17538026"
] | [
"The nucleolar Net1/Cfi1-related protein Dnt1 antagonizes the septation initiation network in fission yeast."
] | [
2007
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
472
] | 1 | [
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
2,
1
] | 2 | true | Domain | Nucleolar protein Dnt1-like, N-terminal | Nucleolar protein Dnt1-like, N-terminal | Dnt1-like_N | 8 |
IPR018845 | 18,845 | Initiator binding domain | Initiator-bd | Domain | 414 | false | false | In Trichomonas vaginalis, thought to be the earliest extant eukaryote, the sole initiator element for control of the start of transcription is Inr, and this is recognised by the initiator binding protein IBP39. IBP39 contains an N-terminal Inr binding domain (IBD, represented by this entry) connected via a flexible, pr... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF10416"
] | [
"IBD"
] | [
414
] | 1 | [] | [] | [] | 0 | [
"1pp7",
"1pp8"
] | 2 | [
"PUB00029945"
] | [
"14622596"
] | [
"Structural basis of core promoter recognition in a primitive eukaryote."
] | [
2003
] | 1 | [] | [] | 0 | 0 | null | [
"Parabasalia"
] | [
414
] | 1 | [] | [] | 0 | true | Domain | Initiator binding domain | Initiator binding domain | Initiator-bd | 5 |
IPR018846 | 18,846 | RSE1/DDB1/CPSF1, first beta-propeller | Beta-prop_RSE1/DDB1/CPSF1_1st | Domain | 15,910 | false | false | This entry represents the β-propeller found towards the N-terminal of RSE1/SF3B3/DDB1/CPSF1/CFT1 proteins from eukaryotes. RSE1/SF3B3/DDB1/CPSF1/CFT1 proteins share a domain architecture consisting of three β-propellers. They have diverse functions, primarily related to RNA/DNA binding. Pre-mRNA-splicing factor RSE1 pl... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF10433"
] | [
"Beta-prop_RSE1_1st"
] | [
15910
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-72163",
"R-BTA-72165",
"R-CEL-110314",
"R-CEL-5696394",
"R-CEL-5696395",
"R-CEL-5696400",
"R-CEL-6781823",
"R-CEL-6782135",
"R-CEL-6782210",
"R-CEL-72187",
"R-CEL-72203",
"R-CEL-73856",
"R-CEL-77595",
"R-CEL-8951664",
"R-DDI-110314",
"R-DDI-5696394",
"R-DDI-5696395",
"R-DDI-... | [
"REACTOME:R-BTA-72163",
"REACTOME:R-BTA-72165",
"REACTOME:R-CEL-110314",
"REACTOME:R-CEL-5696394",
"REACTOME:R-CEL-5696395",
"REACTOME:R-CEL-5696400",
"REACTOME:R-CEL-6781823",
"REACTOME:R-CEL-6782135",
"REACTOME:R-CEL-6782210",
"REACTOME:R-CEL-72187",
"REACTOME:R-CEL-72203",
"REACTOME:R-CEL-7... | 86 | [
"2b5l",
"2b5m",
"2hye",
"3e0c",
"3ei1",
"3ei2",
"3ei3",
"3ei4",
"3i7h",
"3i7k",
"3i7l",
"3i7n",
"3i7o",
"3i7p",
"3i89",
"3i8c",
"3i8e",
"4a08",
"4a09",
"4a0a",
"4a0b",
"4a0k",
"4a0l",
"4a11",
"4ci1",
"4ci2",
"4ci3",
"4e54",
"4e5z",
"4tz4",
"5fqd",
"5gm6"... | 257 | [
"PUB00007715",
"PUB00155537",
"PUB00155538",
"PUB00155539",
"PUB00155540",
"PUB00155541"
] | [
"11421366",
"9819400",
"27185460",
"16940174",
"16407252",
"8929410"
] | [
"The 3'-end-processing factor CPSF is required for the splicing of single-intron pre-mRNAs in vivo.",
"A link between secretion and pre-mRNA processing defects in Saccharomyces cerevisiae and the identification of a novel splicing gene, RSE1.",
"The Spliceosomal Protein SF3B5 is a Novel Component of Drosophila ... | [
2001,
1998,
2016,
2006,
2006,
1996
] | 6 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"marine sediment metagenome"
] | [
15908,
2
] | 2 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
29,
4,
6,
3,
26,
9,
5,
10,
12,
2,
4,
59
] | 12 | true | Domain | RSE1/DDB1/CPSF1, first beta-propeller | RSE1/DDB1/CPSF1, first beta-propeller | Beta-prop_RSE1/DDB1/CPSF1_1st | 1 |
IPR018847 | 18,847 | Monopolin complex, subunit Mam1 | Monopolin_cplx_su_Mam1 | Family | 57 | false | false | Monopolin is a protein complex, originally identified in Saccharomyces cerevisiae (Baker's yeast), that is required for the segregation of homologous centromeres to opposite poles of a dividing cell during meiosis I [ , ]. MAM1 is required in S. cerevisiae for monopolar attachment [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF10434"
] | [
"MAM1"
] | [
57
] | 1 | [] | [] | [] | 0 | [
"5cyz",
"5czo",
"5ktb"
] | 3 | [
"PUB00044337",
"PUB00044338"
] | [
"11163190",
"12689592"
] | [
"Functional genomics identifies monopolin: a kinetochore protein required for segregation of homologs during meiosis i.",
"Kinetochore recruitment of two nucleolar proteins is required for homolog segregation in meiosis I."
] | [
2000,
2003
] | 2 | [] | [] | 0 | 0 | null | [
"Saccharomycetaceae"
] | [
57
] | 1 | [
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)"
] | [
1
] | 1 | true | Family | Monopolin complex, subunit Mam1 | Monopolin complex, subunit Mam1 | Monopolin_cplx_su_Mam1 | 5 |
IPR018848 | 18,848 | WIYLD domain | WIYLD_domain | Domain | 2,830 | false | false | This entry represents the plant-specific WIYLD domain, named based on the pattern of the most conserved residues [ , ]. This is a ubiquitin-binding domain that adopts a four-helix bundle structure, in contrast to the three-helix bundles of other ubiquitin binding domains. It is found in histone-lysine N-methyltransfera... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF10440"
] | [
"WIYLD"
] | [
2830
] | 1 | [] | [] | [] | 0 | [
"2lxe"
] | 1 | [
"PUB00044540",
"PUB00077095",
"PUB00103774"
] | [
"17020925",
"25420628",
"24625295"
] | [
"The Arabidopsis SUVR4 protein is a nucleolar histone methyltransferase with preference for monomethylated H3K9.",
"SUVR2 is involved in transcriptional gene silencing by associating with SNF2-related chromatin-remodeling proteins in Arabidopsis.",
"The arabidopsis histone methyltransferase SUVR4 binds ubiquiti... | [
2006,
2014,
2014
] | 3 | [] | [] | 0 | 0 | null | [
"Embryophyta"
] | [
2830
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
38,
8,
35
] | 3 | true | Domain | WIYLD domain | WIYLD domain | WIYLD_domain | 3 |
IPR018849 | 18,849 | Nucleolar 27S pre-rRNA processing, Urb2/Npa2, C-terminal | Urb2/Npa2_C | Domain | 3,653 | false | false | This entry represents a conserved domain found towards the C terminus of proteins involved in ribosome biogenesis, such as the Urb2 protein from yeast [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF10441"
] | [
"Urb2"
] | [
3653
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00044526"
] | [
"15226434"
] | [
"Npa1p, a component of very early pre-60S ribosomal particles, associates with a subset of small nucleolar RNPs required for peptidyl transferase center modification."
] | [
2004
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
3653
] | 1 | [
"Arabidopsis thaliana",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"... | [
4,
3,
1,
2,
3,
1,
4,
1,
1,
1,
14
] | 11 | true | Domain | Nucleolar 27S pre-rRNA processing, Urb2/Npa2, C-terminal | Nucleolar 27S pre-rRNA processing, Urb2/Npa2, C-terminal | Urb2/Npa2_C | 4 |
IPR018850 | 18,850 | Mitochondrial escape protein 2, C-terminal | Mt_escape_2_C | Domain | 1,807 | false | false | Mitochondrial escape protein 2 (also known as RNA12) plays a role in maintaining the mitochondrial genome and in controlling mtDNA escape [ , ]. It is also involved in the regulation of mtDNA nucleotide structure and number [ ]. Additionally, this protein have a dispensable role in the early maturation of pre-rRNA [ ].... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF10443"
] | [
"RNA12"
] | [
1807
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00044464",
"PUB00044893",
"PUB00044894",
"PUB00044895"
] | [
"1557037",
"8514129",
"8649384",
"16850347"
] | [
"rna12+, a gene of Saccharomyces cerevisiae involved in pre-rRNA maturation. Characterization of a temperature-sensitive mutant, cloning and sequencing of the gene.",
"Nuclear mutations in Saccharomyces cerevisiae that affect the escape of DNA from mitochondria to the nucleus.",
"Inactivation of YME2/RNA12, whi... | [
1992,
1993,
1996,
2006
] | 4 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Macrococcus lamae"
] | [
1806,
1
] | 2 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
1,
1,
1
] | 3 | true | Domain | Mitochondrial escape protein 2, C-terminal | Mitochondrial escape protein 2, C-terminal | Mt_escape_2_C | 4 |
IPR018851 | 18,851 | Borealin, N-terminal | Borealin_N | Domain | 2,864 | false | false | This entry represents the N-terminal domain of borealin, a component of the chromosomal passenger complex (CPC), which acts as a key regulator of mitosis [ , ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF10444"
] | [
"Nbl1_Borealin_N"
] | [
2864
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-HSA-141444",
"R-HSA-2467813",
"R-HSA-2500257",
"R-HSA-4615885",
"R-HSA-5663220",
"R-HSA-68877",
"R-HSA-9648025",
"R-MMU-141444",
"R-MMU-2467813",
"R-MMU-2500257",
"R-MMU-4615885",
"R-MMU-5663220",
"R-MMU-68877",
"R-MMU-9648025",
"R-RNO-141444",
"R-RNO-2467813",
"R-RNO-2500257",
... | [
"REACTOME:R-HSA-141444",
"REACTOME:R-HSA-2467813",
"REACTOME:R-HSA-2500257",
"REACTOME:R-HSA-4615885",
"REACTOME:R-HSA-5663220",
"REACTOME:R-HSA-68877",
"REACTOME:R-HSA-9648025",
"REACTOME:R-MMU-141444",
"REACTOME:R-MMU-2467813",
"REACTOME:R-MMU-2500257",
"REACTOME:R-MMU-4615885",
"REACTOME:R-... | 28 | [
"2qfa",
"2raw",
"2rax",
"6yie",
"6yif",
"6yih",
"8rup",
"8ruq",
"9d41",
"9si3",
"9si9",
"9sj5",
"9slj"
] | 13 | [
"PUB00044173",
"PUB00075522"
] | [
"15249581",
"23175282"
] | [
"Borealin: a novel chromosomal passenger required for stability of the bipolar mitotic spindle.",
"The chromosomal passenger complex (CPC): from easy rider to the godfather of mitosis."
] | [
2004,
2012
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"uncultured organism MedDCM-OCT-S04-C2"
] | [
2863,
1
] | 2 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
9,
2,
2,
1,
2,
1
] | 6 | true | Domain | Borealin, N-terminal | Borealin, N-terminal | Borealin_N | 8 |
IPR018852 | 18,852 | Protein of unknown function DUF2456 | DUF2456 | Family | 580 | false | false | This entry represents a family of uncharacterised proteins. | [] | [] | [] | 0 | [
"PFAM",
"PANTHER"
] | [
"PF10445",
"PTHR28297"
] | [
"DUF2456",
""
] | [
560,
567
] | 2 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
580
] | 1 | [
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
1,
1
] | 2 | true | Family | Protein of unknown function DUF2456 | Protein of unknown function DUF2456 | DUF2456 | 4 |
IPR018853 | 18,853 | Protein of unknown function DUF2457 | DUF2457 | Family | 1,039 | false | false | This entry represents a family of uncharacterised proteins. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF10446"
] | [
"DUF2457"
] | [
1039
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Mythimna unipuncta nucleopolyhedrovirus"
] | [
1038,
1
] | 2 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
1,
1
] | 2 | true | Family | Protein of unknown function DUF2457 | Protein of unknown function DUF2457 | DUF2457 | 8 |
IPR018855 | 18,855 | Proteasome chaperone 1, fungi | Psome_chaperone_1_fun | Family | 173 | false | false | This entry represents fungal proteosome chaperone 1, a chaperone of the 20S proteasome which functions in early 20S proteasome assembly [ ]. | [
"GO:0043248"
] | [
"proteasome assembly"
] | [
"biological_process"
] | 1 | [
"PFAM"
] | [
"PF10450"
] | [
"POC1"
] | [
173
] | 1 | [] | [] | [] | 0 | [
"4g4s",
"7ls6",
"7lsx",
"8rvl",
"8rvo",
"8rvp",
"8t08",
"8u6y"
] | 8 | [
"PUB00044890"
] | [
"17707236"
] | [
"20S proteasome assembly is orchestrated by two distinct pairs of chaperones in yeast and in mammals."
] | [
2007
] | 1 | [] | [] | 0 | 0 | null | [
"Opisthokonta"
] | [
173
] | 1 | [
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)"
] | [
1
] | 1 | true | Family | Proteasome chaperone 1, fungi | Proteasome chaperone 1, fungi | Psome_chaperone_1_fun | 8 |
IPR018857 | 18,857 | TORC1 complex, subunit TCO89 | TORC1_cplx_su_TCO89 | Family | 450 | false | false | TC089 is a component of the TORC1 complex. TORC1 is responsible for a wide range of rapamycin-sensitive cellular activities [ , ]. | [
"GO:0031929",
"GO:0031931"
] | [
"TOR signaling",
"TORC1 complex"
] | [
"biological_process",
"cellular_component"
] | 2 | [
"PFAM"
] | [
"PF10452"
] | [
"TCO89"
] | [
450
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00044236",
"PUB00044891"
] | [
"18076573",
"14736892"
] | [
"Rapamycin sensitivity of the Schizosaccharomyces pombe tor2 mutant and organization of two highly phosphorylated TOR complexes by specific and common subunits.",
"TOR complex 1 includes a novel component, Tco89p (YPL180w), and cooperates with Ssd1p to maintain cellular integrity in Saccharomyces cerevisiae."
] | [
2007,
2004
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
450
] | 1 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
1,
1,
1
] | 3 | true | Family | TORC1 complex, subunit TCO89 | TORC1 complex, subunit TCO89 | TORC1_cplx_su_TCO89 | 2 |
IPR018858 | 18,858 | Protein of unknown function DUF2458 | DUF2458 | Family | 703 | false | false | This entry represents a family of uncharacterised proteins. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF10454"
] | [
"DUF2458"
] | [
703
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
703
] | 1 | [
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
1
] | 1 | true | Family | Protein of unknown function DUF2458 | Protein of unknown function DUF2458 | DUF2458 | 9 |
IPR018859 | 18,859 | BAR domain-containing family | BAR_dom-cont | Family | 1,965 | false | false | Endocytosis and intracellular transport involve several mechanistic steps: For the internalisation of cargo molecules, the membrane needs to bend to form a vesicular structure, which requires membrane curvature and a rearrangement of the cytoskeleton; Following its formation, the vesicle has to be pinched off the membr... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF10455"
] | [
"BAR_2"
] | [
1965
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00014978",
"PUB00044892"
] | [
"14993925",
"18156177"
] | [
"The BAR-domain family of proteins: a case of bending and binding?",
"Proteomic analysis of a nutritional shift-up in Saccharomyces cerevisiae identifies Gvp36 as a BAR-containing protein involved in vesicular traffic and nutritional adaptation."
] | [
2004,
2008
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1965
] | 1 | [
"Drosophila melanogaster",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
1,
2,
2,
1
] | 4 | true | Family | BAR domain-containing family | BAR domain-containing family | BAR_dom-cont | 1 |
IPR018860 | 18,860 | Anaphase-promoting complex, subunit CDC26 | APC_suCDC26 | Family | 1,961 | false | false | This entry represents subunit CDC26, whose exact function is not known [ ]. The anaphase-promoting complex (APC) or cyclosome is a multi-subunit E3 protein ubiquitin ligase that regulates important events in mitosis, such as the initiation of anaphase and exit from telophase. The APC, in conjunction with other enzymes,... | [
"GO:0031145",
"GO:0005680"
] | [
"anaphase-promoting complex-dependent catabolic process",
"anaphase-promoting complex"
] | [
"biological_process",
"cellular_component"
] | 2 | [
"PFAM",
"PANTHER"
] | [
"PF10471",
"PTHR28579"
] | [
"ANAPC_CDC26",
""
] | [
1920,
821
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-141430",
"R-BTA-174048",
"R-BTA-174084",
"R-BTA-174154",
"R-BTA-174178",
"R-BTA-174184",
"R-BTA-176407",
"R-BTA-176408",
"R-BTA-176409",
"R-BTA-176412",
"R-BTA-179409",
"R-BTA-2467813",
"R-BTA-2559582",
"R-BTA-68867",
"R-BTA-69017",
"R-BTA-983168",
"R-DDI-141430",
"R-DDI-174... | [
"REACTOME:R-BTA-141430",
"REACTOME:R-BTA-174048",
"REACTOME:R-BTA-174084",
"REACTOME:R-BTA-174154",
"REACTOME:R-BTA-174178",
"REACTOME:R-BTA-174184",
"REACTOME:R-BTA-176407",
"REACTOME:R-BTA-176408",
"REACTOME:R-BTA-176409",
"REACTOME:R-BTA-176412",
"REACTOME:R-BTA-179409",
"REACTOME:R-BTA-246... | 80 | [
"2xpi",
"3hym",
"4ui9",
"5a31",
"5g04",
"5g05",
"5khr",
"5khu",
"5l9t",
"5l9u",
"5lcw",
"6q6g",
"6q6h",
"6tlj",
"6tm5",
"6tnt",
"8a3t",
"8a5y",
"8a61",
"8pkp",
"8tar",
"8tau",
"9gaw",
"9n9r",
"9n9s"
] | 25 | [
"PUB00044150",
"PUB00059221"
] | [
"10922056",
"18485873"
] | [
"The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex.",
"Mechanism of ubiquitin-chain formation by the human anaphase-promoting complex."
] | [
2000,
2008
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1961
] | 1 | [
"Arabidopsis thaliana",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain ... | [
1,
4,
1,
1,
1,
1,
2,
1,
1
] | 9 | true | Family | Anaphase-promoting complex, subunit CDC26 | Anaphase-promoting complex, subunit CDC26 | APC_suCDC26 | 7 |
IPR018861 | 18,861 | Transmembrane protein 201, C-terminal | TMEM201_C | Domain | 1,038 | false | false | TMEM201, also known as SAMP1, is a RanGTP binding transmembrane protein found in the inner nuclear membrane [ ]. It is functionally associated with the LINC complex protein Sun1 and proteins of the A-type lamina network [ ]. This entry represents the C-terminal domain of TMEM201. | [
"GO:0005637"
] | [
"nuclear inner membrane"
] | [
"cellular_component"
] | 1 | [
"PFAM"
] | [
"PF10476"
] | [
"DUF2448"
] | [
1038
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00086604",
"PUB00086605"
] | [
"27541860",
"21610090"
] | [
"Samp1, a RanGTP binding transmembrane protein in the inner nuclear membrane.",
"Samp1 is functionally associated with the LINC complex and A-type lamina networks."
] | [
2016,
2011
] | 2 | [] | [] | 0 | 0 | null | [
"Amycolatopsis magusensis",
"Bilateria"
] | [
1,
1037
] | 2 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
4,
2,
4,
3
] | 4 | true | Domain | Transmembrane protein 201, C-terminal | Transmembrane protein 201, C-terminal | TMEM201_C | 6 |
IPR018862 | 18,862 | Eukaryotic translation initiation factor 4E binding protein | eIF4E-T | Family | 2,690 | false | false | This entry represents a group of eIF4E binding proteins, including eIF4E transporter (eIF4E-T) from mammals, cup protein from D. melanogaster and ifet-1 from C. elegans. Protein cup functions in Smaug-mediated translational repression [ , ]. Ifet-1 is a broad-scale translational repressor in C. elegans [ , ]. | [] | [] | [] | 0 | [
"PFAM",
"PANTHER"
] | [
"PF10477",
"PTHR12269"
] | [
"EIF4E-T",
""
] | [
2530,
2639
] | 2 | [] | [] | [] | 0 | [
"4ue9",
"5anr"
] | 2 | [
"PUB00044973",
"PUB00075408",
"PUB00075409",
"PUB00075410",
"PUB00075411"
] | [
"10856257",
"14685270",
"21081899",
"23264733",
"19786575"
] | [
"A novel shuttling protein, 4E-T, mediates the nuclear import of the mRNA 5' cap-binding protein, eIF4E.",
"Drosophila Cup is an eIF4E-binding protein that functions in Smaug-mediated translational repression.",
"Smaug assembles an ATP-dependent stable complex repressing nanos mRNA translation at multiple level... | [
2000,
2004,
2011,
2013,
2009
] | 5 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
2690
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
6,
5,
8,
7,
8
] | 6 | true | Family | Eukaryotic translation initiation factor 4E binding protein | Eukaryotic translation initiation factor 4E binding protein | eIF4E-T | 7 |
IPR018864 | 18,864 | Nucleoporin Nup188, N-terminal | Nucleoporin_Nup188_N | Domain | 2,642 | false | false | This protein folds into an extended stack of helices where the N-terminal forms a closed ring (subdivided into subdomains I-III in [ ]) and the C-terminal forms a more regular, superhelical structure [ ]. This entry represents the N-terminal helical repeats from Nup188. Nup188 is one of the many peptides that make up t... | [
"GO:0017056"
] | [
"structural constituent of nuclear pore"
] | [
"molecular_function"
] | 1 | [
"PFAM"
] | [
"PF10487"
] | [
"Nup188_N"
] | [
2642
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-DME-159227",
"R-DME-159230",
"R-DME-159231",
"R-DME-159236",
"R-DME-170822",
"R-DME-3108214",
"R-DME-3301854",
"R-DME-4085377",
"R-DME-4551638",
"R-DME-4615885",
"R-DME-5578749",
"R-DME-9615933",
"R-HSA-1169408",
"R-HSA-159227",
"R-HSA-159230",
"R-HSA-159231",
"R-HSA-159236",
"R... | [
"REACTOME:R-DME-159227",
"REACTOME:R-DME-159230",
"REACTOME:R-DME-159231",
"REACTOME:R-DME-159236",
"REACTOME:R-DME-170822",
"REACTOME:R-DME-3108214",
"REACTOME:R-DME-3301854",
"REACTOME:R-DME-4085377",
"REACTOME:R-DME-4551638",
"REACTOME:R-DME-4615885",
"REACTOME:R-DME-5578749",
"REACTOME:R-D... | 71 | [
"4kf7",
"5ijo",
"7mvw",
"7mvx",
"7mvy",
"7mvz",
"7n84",
"7n85",
"7n9f",
"7r5j",
"7r5k",
"7tbi",
"7tbj",
"7tbk",
"7tbl",
"7tbm",
"7wkk",
"7wo9",
"7woo",
"7wot",
"8tj5"
] | 21 | [
"PUB00044405",
"PUB00044406",
"PUB00091656"
] | [
"11029043",
"16361228",
"23795296"
] | [
"Identification of a new vertebrate nucleoporin, Nup188, with the use of a novel organelle trap assay.",
"The integral membrane protein Pom34p functionally links nucleoporin subcomplexes.",
"Scaffold nucleoporins Nup188 and Nup192 share structural and functional properties with nuclear transport receptors."
] | [
2000,
2006,
2013
] | 3 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
2642
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)"
] | [
1,
2,
1,
2,
1,
4,
1
] | 7 | true | Domain | Nucleoporin Nup188, N-terminal | Nucleoporin Nup188, N-terminal | Nucleoporin_Nup188_N | 2 |
IPR018865 | 18,865 | Inactive serine/threonine-protein kinase 19-like | STK19-like | Family | 2,941 | false | false | This entry represents a group of eukaryotic proteins, including human Inactive serine/threonine-protein kinase 19 (STK19, also known as Winged helix repair factor 1, WHR1), a transcription-coupled repair factor required for nucleotide excision repair [ , , , , ]. It is unlikely to show intrinsic kinase activity as repo... | [] | [] | [] | 0 | [
"PFAM",
"PANTHER"
] | [
"PF10494",
"PTHR15243"
] | [
"Stk19",
""
] | [
2818,
2872
] | 2 | [] | [] | [] | 0 | [
"7xrb",
"8ycm",
"9bz0",
"9er2",
"9fd2"
] | 5 | [
"PUB00044500",
"PUB00044889",
"PUB00151530",
"PUB00160058",
"PUB00160059",
"PUB00160060",
"PUB00160061",
"PUB00160062"
] | [
"9812991",
"16303567",
"32531246",
"39353615",
"39547223",
"39547228",
"39547229",
"38252411"
] | [
"The G11 gene located in the major histocompatibility complex encodes a novel nuclear serine/threonine protein kinase.",
"A large-scale screen in S. pombe identifies seven novel genes required for critical meiotic events.",
"A Reply to ''Evidence that STK19 Is Not an NRAS-Dependent Melanoma Driver\".",
"STK19... | [
1998,
2005,
2020,
2024,
2024,
2024,
2024,
2024
] | 8 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
2941
] | 1 | [
"Arabidopsis thaliana",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)",
"Zea mays"
] | [
9,
2,
8,
4,
4,
9,
1,
8
] | 8 | true | Family | Inactive serine/threonine-protein kinase 19-like | Inactive serine/threonine-protein kinase 19-like | STK19-like | 6 |
IPR018866 | 18,866 | Zinc-finger domain of monoamine-oxidase A repressor R1 | Znf-4CXXC_R1 | Domain | 10,095 | false | false | R1 is a transcription factor repressor that inhibits monoamine oxidase A gene expression. This domain is a four-CXXC zinc finger putative DNA-binding domain found at the C-terminal end of R1. The domain carries 12 cysteines of which four pairs are of the CXXC type [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF10497"
] | [
"zf-4CXXC_R1"
] | [
10095
] | 1 | [] | [] | [] | 0 | [
"8tle",
"8tlf",
"8tlg",
"8tlh",
"8tlj",
"8tlk",
"8tll",
"8yv8"
] | 8 | [
"PUB00044558"
] | [
"15654081"
] | [
"R1, a novel repressor of the human monoamine oxidase A."
] | [
2005
] | 1 | [] | [] | 0 | 0 | null | [
"Candidatus Desantisbacteria bacterium CG_4_10_14_0_8_um_filter_48_22",
"Eukaryota"
] | [
1,
10094
] | 2 | [
"Arabidopsis thaliana",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
43,
4,
6,
2,
1,
27,
12,
86
] | 8 | true | Domain | Zinc-finger domain of monoamine-oxidase A repressor R1 | Zinc-finger domain of monoamine-oxidase A repressor R1 | Znf-4CXXC_R1 | 1 |
IPR018867 | 18,867 | Cell division protein borealin | Cell_div_borealin | Family | 3,394 | false | false | The chromosomal passenger complex of Aurora B kinase, INCENP, and Survivin has essential regulatory roles at centromeres and the central spindle in mitosis. Cell division cycle-associated protein 8, also known as Borealin, is also a member of the complex. Approximately half of Aurora B in mitotic cells is complexed wit... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR16040"
] | [
""
] | [
3394
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-DME-4615885",
"R-HSA-141444",
"R-HSA-2467813",
"R-HSA-2500257",
"R-HSA-4615885",
"R-HSA-5663220",
"R-HSA-68877",
"R-HSA-9648025",
"R-MMU-141444",
"R-MMU-2467813",
"R-MMU-2500257",
"R-MMU-4615885",
"R-MMU-5663220",
"R-MMU-68877",
"R-MMU-9648025",
"R-RNO-141444",
"R-RNO-2467813",
... | [
"REACTOME:R-DME-4615885",
"REACTOME:R-HSA-141444",
"REACTOME:R-HSA-2467813",
"REACTOME:R-HSA-2500257",
"REACTOME:R-HSA-4615885",
"REACTOME:R-HSA-5663220",
"REACTOME:R-HSA-68877",
"REACTOME:R-HSA-9648025",
"REACTOME:R-MMU-141444",
"REACTOME:R-MMU-2467813",
"REACTOME:R-MMU-2500257",
"REACTOME:R-... | 29 | [
"2kdd",
"2qfa",
"2raw",
"2rax",
"6yie",
"6yif",
"6yih",
"8rup",
"8ruq",
"9d41",
"9si3",
"9si9",
"9sj5",
"9slj"
] | 14 | [
"PUB00044173",
"PUB00048322"
] | [
"15249581",
"19530738"
] | [
"Borealin: a novel chromosomal passenger required for stability of the bipolar mitotic spindle.",
"Phosphorylation of a borealin dimerization domain is required for proper chromosome segregation."
] | [
2004,
2009
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"uncultured organism MedDCM-OCT-S04-C2"
] | [
3393,
1
] | 2 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus"
] | [
9,
2,
3,
2,
1,
2
] | 6 | true | Family | Cell division protein borealin | Cell division protein borealin | Cell_div_borealin | 1 |
IPR018868 | 18,868 | Bcl2-associated agonist of cell death | BAD | Family | 646 | false | false | BAD is a Bcl-2 homology domain 3 (BH3)-only pro-apoptotic member of the Bcl-2 protein family that is regulated by phosphorylation in response to survival factors [ ]. Binding of BAD to mitochondria is thought to be exclusively mediated by its BH3 domain. Membrane localisation of BAD mediates membrane translocation of B... | [
"GO:0006915"
] | [
"apoptotic process"
] | [
"biological_process"
] | 1 | [
"PFAM",
"PANTHER"
] | [
"PF10514",
"PTHR28540"
] | [
"Bcl-2_BAD",
""
] | [
645,
642
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-111447",
"R-HSA-111453",
"R-HSA-193648",
"R-HSA-198323",
"R-HSA-5674400",
"R-MMU-111447",
"R-MMU-111453",
"R-MMU-193648",
"R-RNO-111447",
"R-RNO-111453",
"R-RNO-193648"
] | [
"REACTOME:R-HSA-111447",
"REACTOME:R-HSA-111453",
"REACTOME:R-HSA-193648",
"REACTOME:R-HSA-198323",
"REACTOME:R-HSA-5674400",
"REACTOME:R-MMU-111447",
"REACTOME:R-MMU-111453",
"REACTOME:R-MMU-193648",
"REACTOME:R-RNO-111447",
"REACTOME:R-RNO-111453",
"REACTOME:R-RNO-193648"
] | 11 | [
"1g5j",
"2bzw",
"6fbx",
"9o14",
"9o15",
"9o16"
] | 6 | [
"PUB00044167",
"PUB00044168",
"PUB00044169"
] | [
"9372935",
"16226704",
"16603546"
] | [
"Bad is a BH3 domain-containing protein that forms an inactivating dimer with Bcl-XL.",
"The BAD protein integrates survival signaling by EGFR/MAPK and PI3K/Akt kinase pathways in PTEN-deficient tumor cells.",
"Reversible membrane interaction of BAD requires two C-terminal lipid binding domains in conjunction w... | [
1997,
2005,
2006
] | 3 | [] | [] | 0 | 0 | null | [
"Gnathostomata"
] | [
646
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
7,
6,
7,
7
] | 4 | true | Family | Bcl2-associated agonist of cell death | Bcl2-associated agonist of cell death | BAD | 3 |
IPR018870 | 18,870 | Tti2 family | Tti2 | Family | 2,937 | false | false | This family includes budding yeast Tel2-interacting protein 2 (Tti2) and similar proteins from animals and fungi. Tti2 is a component of the tel2-tti1-tti2 (TTT) complex, which is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Its homolo... | [
"GO:0110078"
] | [
"TTT Hsp90 cochaperone complex"
] | [
"cellular_component"
] | 1 | [
"PFAM",
"PANTHER"
] | [
"PF10521",
"PTHR32226"
] | [
"Tti2",
""
] | [
2397,
2263
] | 2 | [] | [] | [] | 0 | [
"7f4u",
"7ole"
] | 2 | [
"PUB00073582",
"PUB00075571",
"PUB00088257",
"PUB00103637",
"PUB00151832"
] | [
"20810650",
"21552543",
"20801936",
"31332096",
"34233195"
] | [
"A genetic screen identifies the Triple T complex required for DNA damage signaling and ATM and ATR stability.",
"The complete spectrum of yeast chromosome instability genes identifies candidate CIN cancer genes and functional roles for ASTRA complex components.",
"Tel2 structure and function in the Hsp90-depen... | [
2010,
2011,
2010,
2019,
2021
] | 5 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"bird metagenome"
] | [
2936,
1
] | 2 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
5,
3,
3,
1,
6,
1,
1
] | 7 | true | Family | Tti2 family | Tti2 family | Tti2 | 9 |
IPR018871 | 18,871 | GLEYA adhesin domain | GLEYA_adhesin_domain | Domain | 2,175 | false | false | The GLEYA domain is related to lectin-like binding domains found in the Saccharomyces cerevisiae Flo proteins and the Candida glabrata Epa proteins [ ]. It is a carbohydrate-binding domain that is found in fungal adhesins (also referred to as agglutinins or flocculins) [ ]. Adhesins with a GLEYA domain possess a typica... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF10528"
] | [
"GLEYA"
] | [
2175
] | 1 | [] | [] | [] | 0 | [
"4a3x",
"4af9",
"4afa",
"4afb",
"4afc",
"4asl",
"4cou",
"4cov",
"4cow",
"4coy",
"4coz",
"4cp0",
"4cp1",
"4cp2",
"4d3w",
"5a3l",
"5a3m",
"6hos",
"6y98",
"6y9j"
] | 20 | [
"PUB00044193",
"PUB00045059",
"PUB00081965",
"PUB00081966",
"PUB00082077"
] | [
"16079914",
"17870620",
"23770896",
"24591055",
"25452419"
] | [
"Molecular analysis of kinetochore architecture in fission yeast.",
"Molecular phylogenetics of ascomycotal adhesins--a novel family of putative cell-surface adhesive proteins in fission yeasts.",
"Proteome of the nematode-trapping cells of the fungus Monacrosporium haptotylum.",
"A novel lily anther-specific... | [
2005,
2008,
2013,
2014,
2014
] | 5 | [
"IPR037524"
] | [] | 1 | 0 | 1 | [
"Bacteria",
"Eukaryota",
"Viruses",
"metagenomes"
] | [
26,
2138,
5,
6
] | 4 | [
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
5
] | 1 | true | Domain | GLEYA adhesin domain | GLEYA adhesin domain | GLEYA_adhesin_domain | 9 |
IPR018873 | 18,873 | KilA-N, DNA-binding domain | KilA-N_DNA-bd_domain | Domain | 4,797 | false | false | This entry represents an N-terminal DNA-binding domain found in a wide range of proteins from bacterial and eukaryotic DNA viruses and their bacterial homologues, they include the poxvirus D6R/N1R and baculoviral Bro protein families. The KilA-N domain is considered to be homologous to the fungal DNA-binding APSES doma... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF10543"
] | [
"ORF6N"
] | [
4797
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00010111"
] | [
"11897024"
] | [
"Extensive domain shuffling in transcription regulators of DNA viruses and implications for the origin of fungal APSES transcription factors."
] | [
2002
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Methanomicrobia",
"Viruses",
"unclassified sequences"
] | [
4550,
5,
10,
131,
101
] | 5 | [] | [] | 0 | true | Domain | KilA-N, DNA-binding domain | KilA-N, DNA-binding domain | KilA-N_DNA-bd_domain | 3 |
IPR018874 | 18,874 | Bacteriophage Mx8, p63, C-terminal | Phage_Mx8_p63_C | Domain | 776 | false | false | This entry represents the C-terminal domain from p63 ( ), one of the proteins of Myxococcus phage Mx8. The function of these proteins are unknown [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF10546"
] | [
"P63C"
] | [
776
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00010111"
] | [
"11897024"
] | [
"Extensive domain shuffling in transcription regulators of DNA viruses and implications for the origin of fungal APSES transcription factors."
] | [
2002
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Viruses",
"ecological metagenomes"
] | [
729,
8,
33,
6
] | 4 | [] | [] | 0 | true | Domain | Bacteriophage Mx8, p63, C-terminal | Bacteriophage Mx8, p63, C-terminal | Phage_Mx8_p63_C | 2 |
IPR018875 | 18,875 | Antirepressor protein ant, N-terminal | Antirepressor_Ant_N | Domain | 1,258 | false | false | The Antirepressor protein ant from Salmonella phage P22 prevents the prophage p22 c2 repressor protein from binding to its operators. It also inhibits the action of other prophage repressor proteins, including those of phages lambda and 434. The synthesis of antirepressor is negatively regulated by the protein products... | [] | [] | [] | 0 | [
"PFAM",
"PRINTS"
] | [
"PF10547",
"PR01994"
] | [
"P22_AR_N",
"ANTIREPRESSR"
] | [
1256,
1065
] | 2 | [] | [] | [] | 0 | [] | 0 | [
"PUB00053715",
"PUB00053716",
"PUB00053717"
] | [
"12562822",
"11053393",
"6350606"
] | [
"Corrected sequence of the bacteriophage p22 genome.",
"Sequence of the genome of Salmonella bacteriophage P22.",
"Primary structure of the immI immunity region of bacteriophage P22."
] | [
2003,
2000,
1983
] | 3 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Viruses",
"metagenomes"
] | [
1145,
104,
9
] | 3 | [] | [] | 0 | true | Domain | Antirepressor protein ant, N-terminal | Antirepressor protein ant, N-terminal | Antirepressor_Ant_N | 6 |
IPR018876 | 18,876 | Bacteriophage P22, antirepressor protein, C-terminal | Phage_P22_antirepressor_C | Domain | 838 | false | false | This entry represents the carboxy-terminal domain of the Enterobacteria phage P22 antirepressor (( ) [ ]. It is found associated with . | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF10548"
] | [
"P22_AR_C"
] | [
838
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00010111"
] | [
"11897024"
] | [
"Extensive domain shuffling in transcription regulators of DNA viruses and implications for the origin of fungal APSES transcription factors."
] | [
2002
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Viruses"
] | [
735,
103
] | 2 | [] | [] | 0 | true | Domain | Bacteriophage P22, antirepressor protein, C-terminal | Bacteriophage P22, antirepressor protein, C-terminal | Phage_P22_antirepressor_C | 9 |
IPR018877 | 18,877 | Bacteriophage P22, Orf201, C-terminal | Phage_P22_Orf201_C | Domain | 855 | false | false | This entry represents the carboxy-terminal domain from ORF11 ( ), one of the proteins of Pseudomonas phage D3 (Bacteriophage D3). The function of these proteins are unknown [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF10549"
] | [
"ORF11CD3"
] | [
855
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00010111"
] | [
"11897024"
] | [
"Extensive domain shuffling in transcription regulators of DNA viruses and implications for the origin of fungal APSES transcription factors."
] | [
2002
] | 1 | [] | [] | 0 | 0 | null | [
"Limosa lapponica baueri",
"Pseudomonadota",
"Viruses",
"bioreactor metagenome"
] | [
1,
754,
99,
1
] | 4 | [] | [] | 0 | true | Domain | Bacteriophage P22, Orf201, C-terminal | Bacteriophage P22, Orf201, C-terminal | Phage_P22_Orf201_C | 5 |
IPR018878 | 18,878 | ORF6C domain | ORF6C_dom | Domain | 1,679 | false | false | This entry represents the carboxy-terminal domain from ORF6 ( ), an antirepressor protein from Lactococcus phage bIL285 [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF10552"
] | [
"ORF6C"
] | [
1679
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00010111"
] | [
"11897024"
] | [
"Extensive domain shuffling in transcription regulators of DNA viruses and implications for the origin of fungal APSES transcription factors."
] | [
2002
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Viruses",
"metagenomes"
] | [
1436,
2,
235,
6
] | 4 | [] | [] | 0 | true | Domain | ORF6C domain | ORF6C domain | ORF6C_dom | 9 |
IPR018879 | 18,879 | MSV199 domain | MSV199_dom | Domain | 242 | false | false | This entry represents the MSV199 domain found in proteins from virus [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF10553"
] | [
"MSV199"
] | [
242
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00010111"
] | [
"11897024"
] | [
"Extensive domain shuffling in transcription regulators of DNA viruses and implications for the origin of fungal APSES transcription factors."
] | [
2002
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Methanosarcina mazei",
"Viruses",
"metagenomes"
] | [
3,
27,
1,
182,
29
] | 5 | [] | [] | 0 | true | Domain | MSV199 domain | MSV199 domain | MSV199_dom | 5 |
IPR018881 | 18,881 | Mitochondrial protein C2orf69 | C2orf69_mit | Family | 2,119 | false | false | This family includes mitochondrial protein C2orf69 from human, previously known as UPF0565, which is an important regulator of human mitochondrial function and may play a role in the respiratory chain and other metabolic pathways [ ]. | [] | [] | [] | 0 | [
"PFAM",
"PANTHER"
] | [
"PF10561",
"PTHR31296"
] | [
"C2orf69",
""
] | [
2006,
2063
] | 2 | [] | [] | [] | 0 | [] | 0 | [
"PUB00098152"
] | [
"33945503"
] | [
"C2orf69 mutations disrupt mitochondrial function and cause a multisystem human disorder with recurring autoinflammation."
] | [
2021
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
2119
] | 1 | [
"Arabidopsis thaliana",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
7,
1,
3,
2,
1,
4,
3,
5
] | 8 | true | Family | Mitochondrial protein C2orf69 | Mitochondrial protein C2orf69 | C2orf69_mit | 8 |
IPR018882 | 18,882 | Calmodulin-binding domain C0, NMDA receptor, NR1 subunit | CaM-bd_C0_NMDA_rcpt_NR1 | Domain | 513 | false | false | This is a very short highly conserved domain that is C-terminal to the cytosolic transmembrane region IV of the NMDA-receptor 1. It has been shown to bind Calmodulin-Calcium with high affinity. The ionotropic N-methyl-D-aspartate receptor (NMDAR) is a major source of calcium flux into neurons in the brain and plays a c... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF10562"
] | [
"CaM_bdg_C0"
] | [
513
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-DME-3928662",
"R-DME-438066",
"R-DME-8849932",
"R-DME-9609736"
] | [
"REACTOME:R-DME-3928662",
"REACTOME:R-DME-438066",
"REACTOME:R-DME-8849932",
"REACTOME:R-DME-9609736"
] | 4 | [] | 0 | [
"PUB00044179"
] | [
"18073110"
] | [
"The NMDA receptor NR1 C1 region bound to calmodulin: structural insights into functional differences between homologous domains."
] | [
2007
] | 1 | [] | [] | 0 | 0 | null | [
"Eumetazoa"
] | [
513
] | 1 | [
"Drosophila melanogaster"
] | [
1
] | 1 | true | Domain | Calmodulin-binding domain C0, NMDA receptor, NR1 subunit | Calmodulin-binding domain C0, NMDA receptor, NR1 subunit | CaM-bd_C0_NMDA_rcpt_NR1 | 4 |
IPR018883 | 18,883 | Delta carbonic anhydrase | Delta_CA | Family | 685 | false | false | Delta carbonic anhydrases are one of the at least five independently evolved families of carbonic anhydrases. Their activities, low CO2-induction, and localizations have been well studied in diatoms [ , ]. The catalytic mechanism of delta CAs is currently unknown. Proteins of this family are also common in bacteria, bu... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF10563"
] | [
"CA_like"
] | [
685
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00098618",
"PUB00098619"
] | [
"24414291",
"27008398"
] | [
"Localization of putative carbonic anhydrases in the marine diatom, Thalassiosira pseudonana.",
"Cloning, Expression and Characterization of the δ-carbonic Anhydrase of Thalassiosira weissflogii (Bacillariophyceae)."
] | [
2014,
2013
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Pseudomonadati",
"ecological metagenomes"
] | [
248,
430,
7
] | 3 | [] | [] | 0 | true | Family | Delta carbonic anhydrase | Delta carbonic anhydrase | Delta_CA | 8 |
IPR018884 | 18,884 | Glutamate [NMDA] receptor, epsilon subunit, C-terminal | NMDAR2_C | Domain | 4,125 | false | false | This domain is found at the C terminus of many NMDA-receptor proteins, many of which are also associated with and . This region is predicted to be a large extra-cellular domain of the NMDA receptor proteins, being highly hydrophilic, and is thought to be integrally involved in the function of the receptor. The region a... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF10565"
] | [
"NMDAR2_C"
] | [
4125
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-CFA-3928662",
"R-CFA-438066",
"R-CFA-5673001",
"R-CFA-8849932",
"R-CFA-9609736",
"R-HSA-3928662",
"R-HSA-438066",
"R-HSA-442982",
"R-HSA-5673001",
"R-HSA-6794361",
"R-HSA-8849932",
"R-HSA-9022699",
"R-HSA-9032500",
"R-HSA-9609736",
"R-HSA-9617324",
"R-HSA-9620244",
"R-MMU-3928662"... | [
"REACTOME:R-CFA-3928662",
"REACTOME:R-CFA-438066",
"REACTOME:R-CFA-5673001",
"REACTOME:R-CFA-8849932",
"REACTOME:R-CFA-9609736",
"REACTOME:R-HSA-3928662",
"REACTOME:R-HSA-438066",
"REACTOME:R-HSA-442982",
"REACTOME:R-HSA-5673001",
"REACTOME:R-HSA-6794361",
"REACTOME:R-HSA-8849932",
"REACTOME:R... | 26 | [
"3nfl",
"7ujp",
"7ujq",
"7ujr",
"7ujs",
"8xlk",
"9c7c",
"9c7e",
"9c7p",
"9c7q",
"9c7r"
] | 11 | [
"PUB00044397"
] | [
"8428958"
] | [
"Molecular characterization of the family of the N-methyl-D-aspartate receptor subunits."
] | [
1993
] | 1 | [] | [] | 0 | 0 | null | [
"Vertebrata"
] | [
4125
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
33,
14,
5,
11
] | 4 | true | Domain | Glutamate [NMDA] receptor, epsilon subunit, C-terminal | Glutamate [NMDA] receptor, epsilon subunit, C-terminal | NMDAR2_C | 3 |
IPR018885 | 18,885 | mRNA-binding domain | mRNA-bd_dom | Domain | 614 | false | false | This conserved domain is found in fungal proteins and appears to be involved in RNA-processing. It binds to poly-adenylated RNA, interacts genetically with mRNA 3'-end processing factors, co-purifies with the nuclear cap-binding protein Cbp20p, and is found in complexes containing other translation factors, such as EIF... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF10567"
] | [
"Nab6_mRNP_bdg"
] | [
614
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Fungi"
] | [
614
] | 1 | [
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)"
] | [
2
] | 1 | true | Domain | mRNA-binding domain | mRNA-binding domain | mRNA-bd_dom | 7 |
IPR018886 | 18,886 | Uncharacterised domain UPF0547 | UPF0547 | Domain | 1,315 | false | false | This domain may well be a type of zinc-finger as it carries two pairs of highly conserved cysteine residues though with no accompanying histidines. Several members are annotated as putative helicases. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF10571"
] | [
"UPF0547"
] | [
1315
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Caudoviricetes",
"Eukaryota",
"metagenomes"
] | [
5,
473,
4,
825,
8
] | 5 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
1,
1,
2
] | 4 | true | Domain | Uncharacterised domain UPF0547 | Uncharacterised domain UPF0547 | UPF0547 | 2 |
IPR018887 | 18,887 | Myeloid-derived growth factor | MYDGF | Family | 1,007 | false | false | The function of myeloid-derived growth factor is to protect and repair the heart after myocardial infarction [ ]. | [] | [] | [] | 0 | [
"PFAM",
"PANTHER"
] | [
"PF10572",
"PTHR31230"
] | [
"UPF0556",
""
] | [
1007,
964
] | 2 | [
"REACTOME"
] | [
"R-HSA-381038"
] | [
"REACTOME:R-HSA-381038"
] | 1 | [
"6o6w",
"6svk",
"6svl"
] | 3 | [
"PUB00074301"
] | [
"25581518"
] | [
"Myeloid-derived growth factor (C19orf10) mediates cardiac repair following myocardial infarction."
] | [
2015
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1007
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
3,
1,
3
] | 4 | true | Family | Myeloid-derived growth factor | Myeloid-derived growth factor | MYDGF | 9 |
IPR018888 | 18,888 | Uncharacterised protein family UPF0561 | UPF0561 | Family | 813 | false | false | This family of proteins has no known function. | [] | [] | [] | 0 | [
"PFAM",
"PANTHER"
] | [
"PF10573",
"PTHR34256"
] | [
"UPF0561",
""
] | [
724,
751
] | 2 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Nocardia terrae"
] | [
812,
1
] | 2 | [
"Caenorhabditis elegans",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
4,
2,
4,
1,
2
] | 5 | true | Family | Uncharacterised protein family UPF0561 | Uncharacterised protein family UPF0561 | UPF0561 | 5 |
IPR018889 | 18,889 | Arpin | Arpin | Family | 661 | false | false | Arpin regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex [ ]. It induces cell turning by pausing cell migration [ ]. | [
"GO:0051126"
] | [
"negative regulation of actin nucleation"
] | [
"biological_process"
] | 1 | [
"PFAM",
"PANTHER"
] | [
"PF10574",
"PTHR31199"
] | [
"UPF0552",
""
] | [
660,
654
] | 2 | [] | [] | [] | 0 | [
"7jpn"
] | 1 | [
"PUB00086692",
"PUB00086693"
] | [
"24132237",
"26235381"
] | [
"Inhibitory signalling to the Arp2/3 complex steers cell migration.",
"The Arp2/3 inhibitory protein arpin induces cell turning by pausing cell migration."
] | [
2013,
2015
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
661
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
6,
1,
3
] | 4 | true | Family | Arpin | Arpin | Arpin | 9 |
IPR018890 | 18,890 | FAM171 | FAM171 | Family | 2,957 | false | false | This family includes FAM171A1, FAM171A2 and FAM171B. FAM171A1 is a type 1 transmembrane glycoprotein also known as astroprincin (APCN) due to its abundant expression in astrocytes. APCN is also expressed in placental trophoblasts, skeletal and heart muscle, kidney and pancreas [ ]. APCN is involved in the regulation of... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR31626"
] | [
""
] | [
2957
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00100164"
] | [
"30312582"
] | [
"Astroprincin (FAM171A1, C10orf38): A Regulator of Human Cell Shape and Invasive Growth."
] | [
2019
] | 1 | [] | [] | 0 | 0 | null | [
"Bilateria",
"bird metagenome"
] | [
2956,
1
] | 2 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
7,
9,
7,
15
] | 4 | true | Family | FAM171 | FAM171 | FAM171 | 4 |
IPR018891 | 18,891 | Abortive phage infection protein, C-terminal | AIPR_C | Domain | 3,766 | false | false | This entry represents the C-terminal domain of abortive infection phage resistance protein often found in restriction modification system operons [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF10592"
] | [
"AIPR"
] | [
3766
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00044141"
] | [
"18346280"
] | [
"MutL homologs in restriction-modification systems and the origin of eukaryotic MORC ATPases."
] | [
2008
] | 1 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Caudoviricetes",
"Eukaryota",
"unclassified sequences"
] | [
81,
3618,
13,
3,
51
] | 5 | [] | [] | 0 | true | Domain | Abortive phage infection protein, C-terminal | Abortive phage infection protein, C-terminal | AIPR_C | 3 |
IPR018892 | 18,892 | Retro-transposon transporting motif | Retro-transposon_transp_CS | Conserved_site | 998 | false | false | This is the highly conserved motif GRKIxxxxxRRKx of nucleoporins that plays a critical and unique role in the nuclear import of retro-transposons in both yeasts and higher organisms. It would appear that the arginine residues at positions 2 and 9-10 constitute a bipartite nuclear localisation signal, with two basic pep... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF10599"
] | [
"Nup_retrotrp_bd"
] | [
998
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-HSA-1169408",
"R-HSA-159227",
"R-HSA-159230",
"R-HSA-159231",
"R-HSA-159236",
"R-HSA-165054",
"R-HSA-168271",
"R-HSA-168276",
"R-HSA-168325",
"R-HSA-168333",
"R-HSA-170822",
"R-HSA-180746",
"R-HSA-180910",
"R-HSA-191859",
"R-HSA-3108214",
"R-HSA-3232142",
"R-HSA-3301854",
"R-HSA... | [
"REACTOME:R-HSA-1169408",
"REACTOME:R-HSA-159227",
"REACTOME:R-HSA-159230",
"REACTOME:R-HSA-159231",
"REACTOME:R-HSA-159236",
"REACTOME:R-HSA-165054",
"REACTOME:R-HSA-168271",
"REACTOME:R-HSA-168276",
"REACTOME:R-HSA-168325",
"REACTOME:R-HSA-168333",
"REACTOME:R-HSA-170822",
"REACTOME:R-HSA-18... | 68 | [] | 0 | [
"PUB00044409"
] | [
"17615301"
] | [
"Multiple conserved domains of the nucleoporin Nup124p and its orthologs Nup1p and Nup153 are critical for nuclear import and activity of the fission yeast Tf1 retrotransposon."
] | [
2007
] | 1 | [] | [] | 0 | 0 | null | [
"Opisthokonta"
] | [
998
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
1,
7,
7,
1
] | 4 | true | Conserved_site | Retro-transposon transporting motif | Retro-transposon transporting motif | Retro-transposon_transp_CS | 1 |
IPR018893 | 18,893 | Type VIII secretion system, CsgF | T8SS_CsgF | Family | 2,184 | false | false | The extracellular nucleation-precipitation (ENP) pathway or Type VIII secretion system (T8SS) in Gram-negative (diderm) bacteria is responsible for the secretion and assembly of prepilins for fimbiae biogenesis, the prototypical curli. Besides the T2SS that can be involved in the assembly of prototypical Type 4 pilus, ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF10614"
] | [
"CsgF"
] | [
2184
] | 1 | [] | [] | [] | 0 | [
"5m1u",
"6l7a",
"6l7c",
"6lqh",
"6lqj",
"6si7",
"7brm"
] | 7 | [
"PUB00044216",
"PUB00044511"
] | [
"11823641",
"17379722"
] | [
"Role of Escherichia coli curli operons in directing amyloid fiber formation.",
"AgfC and AgfE facilitate extracellular thin aggregative fimbriae synthesis in Salmonella enteritidis."
] | [
2002,
2007
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Beauveria bassiana D1-5",
"Viruses",
"ecological metagenomes"
] | [
2154,
1,
12,
17
] | 4 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Type VIII secretion system, CsgF | Type VIII secretion system, CsgF | T8SS_CsgF | 1 |
IPR018894 | 18,894 | Protein of unknown function DUF2471 | DUF2471 | Family | 534 | false | false | The function of this family is unknown. Members come from Burkholderiales. A number of proteins in this entry are annotated as serine/threonine-protein kinases. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF10616"
] | [
"DUF2471"
] | [
534
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Burkholderiales",
"Necator americanus"
] | [
533,
1
] | 2 | [] | [] | 0 | true | Family | Protein of unknown function DUF2471 | Protein of unknown function DUF2471 | DUF2471 | 1 |
IPR018895 | 18,895 | Protein of unknown function DUF2474 | DUF2474 | Family | 2,602 | false | false | This family of short proteins has no known function. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF10617"
] | [
"DUF2474"
] | [
2602
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"ecological metagenomes"
] | [
2596,
6
] | 2 | [] | [] | 0 | true | Family | Protein of unknown function DUF2474 | Protein of unknown function DUF2474 | DUF2474 | 2 |
IPR018897 | 18,897 | Plasmid conjugative transfer protein PilI | Plasmid_conjug_transfer_PilI | Domain | 299 | false | false | The thin pilus of plasmid R64 belongs to the type IV family and is required for liquid matings. PilI is one of 14 genes that have been identified as being involved in the biogenesis of the R64 thin pilus [ ]. According to structure prediction, proteins in this family adopt a compact domain composed of five β strands an... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF10623"
] | [
"PilI"
] | [
299
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00021009"
] | [
"9171405"
] | [
"The plasmid R64 thin pilus identified as a type IV pilus."
] | [
1997
] | 1 | [] | [] | 0 | 0 | null | [
"Plasmid R64",
"Pseudomonadota",
"mine drainage metagenome"
] | [
1,
296,
2
] | 3 | [] | [] | 0 | true | Domain | Plasmid conjugative transfer protein PilI | Plasmid conjugative transfer protein PilI | Plasmid_conjug_transfer_PilI | 2 |
IPR018898 | 18,898 | Plasmid conjugative transfer entry exclusion protein TraS | Eex_TraS | Family | 316 | false | false | Entry exclusion (Eex) is a process which prevents redundant transfer of DNA between donor cells. TraS is a protein involved in Eex. It blocks redundant conjugative DNA synthesis and transport between donor cells, and it is suggested that TraS interferes with a signalling pathway that is required to trigger DNA transfer... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF10624"
] | [
"TraS"
] | [
316
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00044521"
] | [
"17259615"
] | [
"Entry exclusion in F-like plasmids requires intact TraG in the donor that recognizes its cognate TraS in the recipient."
] | [
2007
] | 1 | [] | [] | 0 | 0 | null | [
"Pseudomonadati",
"human gut metagenome"
] | [
313,
3
] | 2 | [] | [] | 0 | true | Family | Plasmid conjugative transfer entry exclusion protein TraS | Plasmid conjugative transfer entry exclusion protein TraS | Eex_TraS | 4 |
IPR018899 | 18,899 | Conjugative transposon, TraO | Conjug_transposon_Tra0 | Family | 2,017 | false | false | This is a family of conjugative transposon proteins. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF10626"
] | [
"TraO"
] | [
2017
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Triatoma infestans",
"metagenomes",
"virus sp. ctLpa4"
] | [
1969,
1,
45,
2
] | 4 | [] | [] | 0 | true | Family | Conjugative transposon, TraO | Conjugative transposon, TraO | Conjug_transposon_Tra0 | 8 |
IPR018900 | 18,900 | Curli assembly protein CsgE | Curli_CsgE | Family | 2,005 | false | false | Curli are a class highly aggregated surface fibres that are part of a complex extracellular matrix. They promote biofilm formation in addition to other activities. CsgE is a non-structural protein involved in curli biogenesis [ ]. CsgE forms an outer membrane complex with the curli assembly proteins CsgG and CsgF [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF10627"
] | [
"CsgE"
] | [
2005
] | 1 | [] | [] | [] | 0 | [
"2na4"
] | 1 | [
"PUB00044216",
"PUB00044217"
] | [
"11823641",
"16420357"
] | [
"Role of Escherichia coli curli operons in directing amyloid fiber formation.",
"Secretion of curli fibre subunits is mediated by the outer membrane-localized CsgG protein."
] | [
2002,
2006
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Tanacetum cinerariifolium",
"ecological metagenomes"
] | [
1996,
1,
8
] | 3 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Curli assembly protein CsgE | Curli assembly protein CsgE | Curli_CsgE | 9 |
IPR018901 | 18,901 | Spore coat protein CotE | Spore_coat_CotE | Family | 1,389 | false | false | CotE is a morphogenic protein that is required for the assembly of the outer coat of the endospore [ ] and spore resistance to lysozyme [ ]. CotE also regulates the expression of cotA, cotB, cotC and other genes encoding spore outer coat proteins [ ]. The timing of cotE expression has been shown in Bacillus subtilis to... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF10628"
] | [
"CotE"
] | [
1389
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00044208",
"PUB00044209"
] | [
"3139490",
"17172339"
] | [
"Gene encoding a morphogenic protein required in the assembly of the outer coat of the Bacillus subtilis endospore.",
"The timing of cotE expression affects Bacillus subtilis spore coat morphology but not lysozyme resistance."
] | [
1988,
2007
] | 2 | [] | [] | 0 | 0 | null | [
"Bacillati",
"Rhizophagus irregularis",
"human gut metagenome"
] | [
1387,
1,
1
] | 3 | [] | [] | 0 | true | Family | Spore coat protein CotE | Spore coat protein CotE | Spore_coat_CotE | 5 |
IPR018902 | 18,902 | Ciliary microtubule inner protein 2A-C-like domain | CMI2A-C-like_dom | Domain | 2,516 | false | false | This entry represents a domain found in a group of eukaryotic proteins, including human Ciliary microtubule inner protein 2A-C-like (CMI2A-C-like). CMI2B/C are microtubule inner proteins (MIPs) that form part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beatin... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF10629"
] | [
"CMI2B-like"
] | [
2516
] | 1 | [] | [] | [] | 0 | [
"7rro",
"7ung",
"8g2z",
"8g3d",
"8i7o",
"8i7r",
"8iyj",
"8j07",
"8otz",
"8sf7",
"8snb",
"8to0",
"9cpb",
"9cpc",
"9fqr"
] | 15 | [
"PUB00103594"
] | [
"36191189"
] | [
"SPACA9 is a lumenal protein of human ciliary singlet and doublet microtubules."
] | [
2022
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
2516
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
5,
3,
6,
6,
8
] | 5 | true | Domain | Ciliary microtubule inner protein 2A-C-like domain | Ciliary microtubule inner protein 2A-C-like domain | CMI2A-C-like_dom | 4 |
IPR018903 | 18,903 | Proline-rich protein 23 | PRR23 | Family | 437 | false | false | This entry represents proline-rich protein 23 (PRR23) family. The funciton of this family is not clear. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF10630"
] | [
"DUF2476"
] | [
437
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Amniota"
] | [
437
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
6,
4,
7
] | 3 | true | Family | Proline-rich protein 23 | Proline-rich protein 23 | PRR23 | 1 |
IPR018904 | 18,904 | Uncharacterised protein family UPF0574 | UPF0574 | Family | 196 | false | false | This is a family of proteins with no known function. The family is rich in proline residues. | [] | [] | [] | 0 | [
"PFAM",
"PANTHER"
] | [
"PF10631",
"PTHR37879"
] | [
"DUF2477",
""
] | [
195,
170
] | 2 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota"
] | [
2,
194
] | 2 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
2,
2
] | 3 | true | Family | Uncharacterised protein family UPF0574 | Uncharacterised protein family UPF0574 | UPF0574 | 6 |
IPR018905 | 18,905 | Alpha-galactosidase, NEW3 domain | A-galactase_NEW3 | Domain | 5,956 | false | false | This domain has been named NEW3, but its function is not known. It is found on proteins which are bacterial galactosidases [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF10633"
] | [
"NPCBM_assoc"
] | [
5956
] | 1 | [] | [] | [] | 0 | [
"1eut",
"1euu",
"1w8n",
"1w8o",
"1wcq",
"2ber",
"2bzd"
] | 7 | [
"PUB00044300"
] | [
"15285616"
] | [
"[Phylogenetic analysis of alpha-galactosidases of the GH27 family]"
] | [
2004
] | 1 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Haptolina brevifila",
"unclassified sequences"
] | [
374,
5539,
1,
42
] | 4 | [] | [] | 0 | true | Domain | Alpha-galactosidase, NEW3 domain | Alpha-galactosidase, NEW3 domain | A-galactase_NEW3 | 4 |
IPR018906 | 18,906 | DNA integrity scanning, DisA, linker region | DNA_integrity_scan_DisA_link | Domain | 4,747 | false | false | The DisA protein is a bacterial checkpoint protein that dimerises into an octameric complex. The protein consists of three distinct domains. the first, N-terminal region, from 1-145 is globular and is represented by ; the next 146-289 residues is this domain that consists of an elongated bundle of three α-helices (α6, ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF10635"
] | [
"DisA-linker"
] | [
4747
] | 1 | [
"EC"
] | [
"2.7.7.85"
] | [
"EC:2.7.7.85"
] | 1 | [
"3c1y",
"3c1z",
"3c21",
"3c23",
"4yvz",
"4yxj",
"4yxm",
"7y0d",
"9y4s",
"9y9y"
] | 10 | [
"PUB00044227"
] | [
"18439896"
] | [
"Structural biochemistry of a bacterial checkpoint protein reveals diadenylate cyclase activity regulated by DNA recombination intermediates."
] | [
2008
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
4679,
7,
61
] | 3 | [] | [] | 0 | true | Domain | DNA integrity scanning, DisA, linker region | DNA integrity scanning, DisA, linker region | DNA_integrity_scan_DisA_link | 1 |
IPR018907 | 18,907 | Spindle body associated protein, C-terminal domain | Spindle_body_associated_C_dom | Domain | 65 | false | false | This C-terminal domain of spindle-body-associated protein Sfi1 has an important role to play in the bridge-splitting during bi-polar spindle assembly, and this separation event possibly requires interaction with integral components of the nuclear envelope, such as the Mps2-Bbp1 complex [ ]. Centrally to this domain is ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF10638"
] | [
"Sfi1_C"
] | [
65
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00044488"
] | [
"17392514"
] | [
"Novel sfi1 alleles uncover additional functions for Sfi1p in bipolar spindle assembly and function."
] | [
2007
] | 1 | [] | [] | 0 | 0 | null | [
"Saccharomycetes"
] | [
65
] | 1 | [
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)"
] | [
1
] | 1 | true | Domain | Spindle body associated protein, C-terminal domain | Spindle body associated protein, C-terminal domain | Spindle_body_associated_C_dom | 5 |
IPR018908 | 18,908 | Putative transmembrane family 234 | TMEM234 | Family | 3,436 | false | false | TMEM234 is a family of putative inner membrane proteins. Many bacterial members are annotated as putative L-Ara4N-phosphoundecaprenol flippase subunit ArnE, and as inner membrane proteins. They may be transporters of the multi-drug-resistant superfamily. | [] | [] | [] | 0 | [
"PFAM",
"PANTHER"
] | [
"PF10639",
"PTHR28668"
] | [
"TMEM234",
""
] | [
3424,
3187
] | 2 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Mimiviridae sp. ChoanoV1"
] | [
3,
113,
3319,
1
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
3,
1,
2,
7,
3,
10,
1,
2,
4,
3
] | 10 | true | Family | Putative transmembrane family 234 | Putative transmembrane family 234 | TMEM234 | 5 |
IPR018909 | 18,909 | Endo-1,3(4)-beta-glucanase 1, carbohydrate binding | Eng1_septum | Domain | 501 | false | false | This is a carbohydrate binding domain found in Schizosaccharomyces pombe endo-1,3(4)-beta-glucanase 1 (Eng1). It is required for septum localisation [ ]. | [
"GO:0030246"
] | [
"carbohydrate binding"
] | [
"molecular_function"
] | 1 | [
"PFAM"
] | [
"PF10645"
] | [
"Carb_bind"
] | [
501
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00044180"
] | [
"18466295"
] | [
"The Schizosaccharomyces pombe endo-1,3-beta-glucanase Eng1 contains a novel carbohydrate binding module required for septum localization."
] | [
2008
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
501
] | 1 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
1,
1
] | 2 | true | Domain | Endo-1,3(4)-beta-glucanase 1, carbohydrate binding | Endo-1,3(4)-beta-glucanase 1, carbohydrate binding | Eng1_septum | 2 |
IPR018910 | 18,910 | Lipoprotein LpqB, C-terminal domain | LpqB_C | Domain | 4,330 | false | false | The Gmad1 domain is found associated with in LpqB. It is predicted to have a β-propeller fold and to have a passive binding role rather than a catalytic function owing to the low number of conserved hydrophilic residues. LpqB may modulate activity of the MtrAB system in controlling homeostasis of the cell wall and cell... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF10647"
] | [
"Gmad1"
] | [
4330
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00104902"
] | [
"20233304"
] | [
"A lipoprotein modulates activity of the MtrAB two-component system to provide intrinsic multidrug resistance, cytokinetic control and cell wall homeostasis in Mycobacterium."
] | [
2010
] | 1 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
6,
4257,
16,
51
] | 4 | [] | [] | 0 | true | Domain | Lipoprotein LpqB, C-terminal domain | Lipoprotein LpqB, C-terminal domain | LpqB_C | 3 |
IPR018911 | 18,911 | Bacterial spore germination, immunoglobulin-like domain | Gmad2_Ig-like_dom | Domain | 1,935 | false | false | This domain is found linked to in some bacterial proteins. It is predicted to contain an immunoglobulin-like all-β fold [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF10648"
] | [
"Gmad2"
] | [
1935
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00044986"
] | [
"7926687"
] | [
"Molecular genetical and phenotypical analysis of the gerM spore germination gene of Bacillus subtilis 168."
] | [
1994
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"metagenomes"
] | [
1906,
29
] | 2 | [] | [] | 0 | true | Domain | Bacterial spore germination, immunoglobulin-like domain | Bacterial spore germination, immunoglobulin-like domain | Gmad2_Ig-like_dom | 8 |
IPR018912 | 18,912 | Protein of unknown function DUF2478 | DUF2478 | Family | 1,471 | false | false | This is a family of hypothetical bacterial proteins encoded in the vicinity of molybdenum ABC transporter gene-products MobA, MobB and MobC. However the function could not be confirmed. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF10649"
] | [
"DUF2478"
] | [
1471
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Heterorhabditis bacteriophora",
"Pseudomonadati",
"unclassified sequences"
] | [
1,
1457,
13
] | 3 | [] | [] | 0 | true | Family | Protein of unknown function DUF2478 | Protein of unknown function DUF2478 | DUF2478 | 4 |
IPR018913 | 18,913 | BppU, N-terminal | BppU_N | Domain | 1,876 | false | false | This is the N-terminal domain of baseplate upper proteins (BppU, also known as ORF48) which is found in bacteriophages. The N-terminal domain exhibits a β-sandwich immunoglobulin fold [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF10651"
] | [
"BppU_N"
] | [
1876
] | 1 | [] | [] | [] | 0 | [
"3uh8",
"4v96",
"6v8i"
] | 3 | [
"PUB00059344"
] | [
"22611190"
] | [
"Structure of the phage TP901-1 1.8 MDa baseplate suggests an alternative host adhesion mechanism."
] | [
2012
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Halobacteriales",
"Popillia japonica",
"Viruses",
"metagenomes"
] | [
1434,
7,
2,
415,
18
] | 5 | [] | [] | 0 | true | Domain | BppU, N-terminal | BppU, N-terminal | BppU_N | 9 |
IPR018914 | 18,914 | Protein of unknown function DUF2480 | DUF2480 | Family | 2,072 | false | false | All the members of this family are uncharacterised proteins, but the environment in which they are found on the bacterial genome suggests a function as a glucose-6-phosphate isomerase ( ). This could not, however, be confirmed. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF10652"
] | [
"DUF2480"
] | [
2072
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Opisthokonta",
"ecological metagenomes"
] | [
2041,
4,
27
] | 3 | [] | [] | 0 | true | Family | Protein of unknown function DUF2480 | Protein of unknown function DUF2480 | DUF2480 | 3 |
IPR018915 | 18,915 | Bacteriophage A118, Gp45 | Phage_A118_Gp45 | Family | 50 | false | false | The proteins in this entry represents Gp45 in Listeria phage A118 (Bacteriophage A118) and related proteins; Gp45 is thought to have a function in the phage tail-fibre system. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF10653"
] | [
"Phage-A118_gp45"
] | [
50
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Listeria",
"Viruses"
] | [
44,
6
] | 2 | [] | [] | 0 | true | Family | Bacteriophage A118, Gp45 | Bacteriophage A118, Gp45 | Phage_A118_Gp45 | 2 |
IPR018916 | 18,916 | Protein of unknown function DUF2481 | DUF2481 | Family | 58 | false | false | This is a hypothetical protein family homologous to Lmo2305 in Bacteriophage A118 systems. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF10654"
] | [
"DUF2481"
] | [
58
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Aquingentivirus",
"Bacillota"
] | [
6,
52
] | 2 | [] | [] | 0 | true | Family | Protein of unknown function DUF2481 | Protein of unknown function DUF2481 | DUF2481 | 1 |
IPR018917 | 18,917 | Protein of unknown function DUF2482 | DUF2482 | Family | 64 | false | false | This entry represents a group of phage proteins with unknown function. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF10655"
] | [
"DUF2482"
] | [
64
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Caudoviricetes",
"Staphylococcus"
] | [
26,
38
] | 2 | [] | [] | 0 | true | Family | Protein of unknown function DUF2482 | Protein of unknown function DUF2482 | DUF2482 | 3 |
IPR018918 | 18,918 | Protein of unknown function DUF2483 | DUF2483 | Family | 141 | false | false | This is a family of unknown function is found in tailed bacteriophages and suspected prophages found in Firmicutes. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF10656"
] | [
"DUF2483"
] | [
141
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacillota",
"Viruses"
] | [
91,
50
] | 2 | [] | [] | 0 | true | Family | Protein of unknown function DUF2483 | Protein of unknown function DUF2483 | DUF2483 | 8 |
IPR018919 | 18,919 | Protein of unknown function DUF2484 | DUF2484 | Family | 819 | false | false | A role of this family in UDP-N-acetylenolpyruvoylglucosamine reductase, as MurB, could not be confirmed. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF10658"
] | [
"DUF2484"
] | [
819
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Pseudomonadati",
"ecological metagenomes"
] | [
811,
8
] | 2 | [] | [] | 0 | true | Family | Protein of unknown function DUF2484 | Protein of unknown function DUF2484 | DUF2484 | 3 |
IPR018920 | 18,920 | ESAT-6 secretion machinery protein EssA/YueC | EssA/YueC | Family | 686 | false | false | Mycobacterium tuberculosis secretes ESAT-6, a virulence factor belonging to the WXG100 family. Other Gram-positive human pathogens belonging to the phylum Firmicutes, e.g. Staphylococcus aureus, also secrete immune potent WXG100 proteins. S. aureus secretes ESAT-6-like proteins EsxA and EsxB. In S.aureus the WXG100 pro... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"TIGR03927"
] | [
"T7SS_EssA_Firm"
] | [
686
] | 1 | [
"GP"
] | [
"GenProp0905"
] | [
"GP:GenProp0905"
] | 1 | [] | 0 | [
"PUB00044252",
"PUB00044259",
"PUB00057458",
"PUB00082315",
"PUB00082316"
] | [
"16911044",
"15657139",
"20852931",
"24798022",
"23861817"
] | [
"The protein secretion systems in Listeria: inside out bacterial virulence.",
"EsxA and EsxB are secreted by an ESAT-6-like system that is required for the pathogenesis of Staphylococcus aureus infections.",
"New insights into the distribution of WXG100 protein secretion systems.",
"The ESX system in Bacillus... | [
2006,
2005,
2011,
2014,
2013
] | 5 | [] | [
"IPR034026"
] | 0 | 1 | 0 | [
"Bacteria"
] | [
686
] | 1 | [] | [] | 0 | true | Family | ESAT-6 secretion machinery protein EssA/YueC | ESAT-6 secretion machinery protein EssA/YueC | EssA/YueC | 8 |
IPR018922 | 18,922 | NAD(P)H-quinone oxidoreductase subunit M | NdhM | Family | 908 | false | false | The NADH dehydrogenase I complex shuttles electrons from an unknown electron donor, via FMN and iron-sulphur (Fe-S) centres, to quinones in the respiratory and/or the photosynthetic chain. The immediate electron acceptor for the enzyme in plants is believed to be plastoquinone. The NADH dehydrogenase I complex couples ... | [
"GO:0016655"
] | [
"oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor"
] | [
"molecular_function"
] | 1 | [
"HAMAP",
"PFAM",
"PANTHER"
] | [
"MF_01352",
"PF10664",
"PTHR36900"
] | [
"NDH1_NDH1M",
"NdhM",
""
] | [
355,
908,
900
] | 3 | [
"EC"
] | [
"7.1.1.-"
] | [
"EC:7.1.1.-"
] | 1 | [
"6hum",
"6khi",
"6khj",
"6l7o",
"6l7p",
"6nbq",
"6nbx",
"6nby",
"6tjv",
"7eu3",
"7f9o",
"7wfg",
"7wg5",
"9grx"
] | 14 | [
"PUB00045281"
] | [
"15608332"
] | [
"New subunits NDH-M, -N, and -O, encoded by nuclear genes, are essential for plastid Ndh complex functioning in higher plants."
] | [
2005
] | 1 | [] | [] | 0 | 0 | null | [
"Cyanobacteriota",
"Eukaryota"
] | [
366,
542
] | 2 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
3,
1,
5
] | 3 | true | Family | NAD(P)H-quinone oxidoreductase subunit M | NAD(P)H-quinone oxidoreductase subunit M | NdhM | 2 |
IPR018923 | 18,923 | Phage tail assembly chaperone protein Gp14 | Phage_TAC_8 | Family | 36 | false | false | This phage protein family is expressed from within a cluster of tail- and base plate-producing genes [ ]. It is a family of tail assembly chaperone proteins [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF10666"
] | [
"Phage_TAC_8"
] | [
36
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00044433",
"PUB00075454"
] | [
"14507382",
"23542344"
] | [
"Genome and proteome of Listeria monocytogenes phage PSA: an unusual case for programmed + 1 translational frameshifting in structural protein synthesis.",
"A conserved spiral structure for highly diverged phage tail assembly chaperones."
] | [
2003,
2013
] | 2 | [] | [] | 0 | 0 | null | [
"Aquingentivirus",
"Listeria"
] | [
6,
30
] | 2 | [] | [] | 0 | true | Family | Phage tail assembly chaperone protein Gp14 | Phage tail assembly chaperone protein Gp14 | Phage_TAC_8 | 8 |
IPR018924 | 18,924 | Protein of unknown function DUF2486 | DUF2486 | Family | 533 | false | false | This family is made up of members from various Burkholderia spp. The function is unknown. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF10667"
] | [
"DUF2486"
] | [
533
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Pseudomonadota"
] | [
533
] | 1 | [] | [] | 0 | true | Family | Protein of unknown function DUF2486 | Protein of unknown function DUF2486 | DUF2486 | 4 |
IPR018925 | 18,925 | PBSX phage terminase small subunit-like, N-terminal domain | XtmA-like_N | Domain | 982 | false | false | This entry represents the N-terminal domain of PBSX phage terminase small subunit from Bacillus subtilis (XtmA) mainly found in firmicutes and some species of tailed bacteriophages. Members of this group share protein sequence similarity with the phage terminase small subunit. Packaging of double-stranded viral DNA con... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF10668"
] | [
"Phage_terminase"
] | [
982
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00008403"
] | [
"2679356"
] | [
"DNA packaging in dsDNA bacteriophages."
] | [
1989
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Methanothermobacter thermautotrophicus",
"Opisthokonta",
"Viruses"
] | [
925,
1,
2,
54
] | 4 | [] | [] | 0 | true | Domain | PBSX phage terminase small subunit-like, N-terminal domain | PBSX phage terminase small subunit-like, N-terminal domain | XtmA-like_N | 9 |
IPR018926 | 18,926 | Gp23 | Gp23 | Family | 35 | false | false | This entry represents the major tail subunit protein, Gp23 of Listeria. Its function is unclear. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF10669"
] | [
"Phage_Gp23"
] | [
35
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00009633"
] | [
"10652093"
] | [
"Complete nucleotide sequence, molecular analysis and genome structure of bacteriophage A118 of Listeria monocytogenes: implications for phage evolution."
] | [
2000
] | 1 | [] | [] | 0 | 0 | null | [
"Bacilli",
"Viruses"
] | [
29,
6
] | 2 | [] | [] | 0 | true | Family | Gp23 | Gp23 | Gp23 | 4 |
IPR018927 | 18,927 | Toxin co-regulated pilus biosynthesis protein Q, C-terminal | Pilus_synth_Q_C | Domain | 2,356 | false | false | The toxin-coregulated pilus (TCP) of Vibrio cholerae and the soluble TcpF protein that is secreted via the TCP biogenesis apparatus are essential for intestinal colonisation in the disease of cholera. TCP fibres are homopolymers of TcpA pilin, encoded by the first gene in the tcp biogenesis operon. TcpQ is part of an o... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF10671"
] | [
"TcpQ"
] | [
2356
] | 1 | [] | [] | [] | 0 | [
"2l4w",
"3ov5",
"6gyb",
"9u5s"
] | 4 | [
"PUB00045152",
"PUB00045153"
] | [
"1358749",
"15774863"
] | [
"TCP pilus biosynthesis in Vibrio cholerae O1: gene sequence of tcpC encoding an outer membrane lipoprotein.",
"Identification of a TcpC-TcpQ outer membrane complex involved in the biogenesis of the toxin-coregulated pilus of Vibrio cholerae."
] | [
1992,
2005
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Plasmid R64",
"metagenomes"
] | [
2329,
4,
1,
22
] | 4 | [] | [] | 0 | true | Domain | Toxin co-regulated pilus biosynthesis protein Q, C-terminal | Toxin co-regulated pilus biosynthesis protein Q, C-terminal | Pilus_synth_Q_C | 8 |
IPR018928 | 18,928 | Generative cell specific-1/HAP2 domain | HAP2/GCS1_dom | Domain | 1,421 | false | false | The gene encoding Arabidopsis HAP2 is allelic with GCS1 (Generative cell-specific protein 1). HAP2 is expressed only in the haploid sperm and is required for efficient guidance of the pollen tube to the ovules. In Arabidopsis the protein is a predicted membrane protein with an N-terminal secretion signal, a single tran... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF10699"
] | [
"HAP2-GCS1"
] | [
1421
] | 1 | [] | [] | [] | 0 | [
"5mf1",
"5ow3",
"5ow4",
"6dbs",
"6e18",
"7s0k"
] | 6 | [
"PUB00044291",
"PUB00044292",
"PUB00044293"
] | [
"17079265",
"18367645",
"18403203"
] | [
"Arabidopsis HAP2 (GCS1) is a sperm-specific gene required for pollen tube guidance and fertilization.",
"The conserved plant sterility gene HAP2 functions after attachment of fusogenic membranes in Chlamydomonas and Plasmodium gametes.",
"Male fertility of malaria parasites is determined by GCS1, a plant-type ... | [
2006,
2008,
2008
] | 3 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1421
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
4,
3,
16
] | 3 | true | Domain | Generative cell specific-1/HAP2 domain | Generative cell specific-1/HAP2 domain | HAP2/GCS1_dom | 2 |
IPR018929 | 18,929 | Domain of unknown function DUF2510 | DUF2510 | Domain | 6,458 | false | false | This domain of unknown function is found in a family of proteins conserved in Actinobacteria. Many members are annotated as putative membrane proteins but this could not be confirmed. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF10708"
] | [
"DUF2510"
] | [
6458
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Mugilogobius chulae",
"Viruses",
"metagenomes"
] | [
6236,
1,
109,
112
] | 4 | [] | [] | 0 | true | Domain | Domain of unknown function DUF2510 | Domain of unknown function DUF2510 | DUF2510 | 6 |
IPR018930 | 18,930 | Late embryogenesis abundant protein, LEA-18 | LEA-18 | Family | 607 | false | false | This is a family of late embryogenesis-abundant proteins There is high accumulation of this protein in dry seeds, and in the roots of full-grown plants in response to dehydration and ABA (abscisic acid application) treatments [ ]. This LEA protein disappears after germination. It accumulates in growing regions of well ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF10714"
] | [
"LEA_6"
] | [
607
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00009713",
"PUB00044331",
"PUB00044332",
"PUB00044333"
] | [
"10681550",
"9349263",
"10318687",
"11414610"
] | [
"Highly hydrophilic proteins in prokaryotes and eukaryotes are common during conditions of water deficit.",
"Characterization of Phaseolus vulgaris cDNA clones responsive to water deficit: identification of a novel late embryogenesis abundant-like protein.",
"Pvlea-18, a member of a new late-embryogenesis-abund... | [
2000,
1997,
1999,
2001
] | 4 | [] | [] | 0 | 0 | null | [
"Magnoliopsida"
] | [
607
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
11,
4,
2
] | 3 | true | Family | Late embryogenesis abundant protein, LEA-18 | Late embryogenesis abundant protein, LEA-18 | LEA-18 | 4 |
IPR018931 | 18,931 | Domain of unknown function DUF2520 | DUF2520 | Domain | 9,048 | false | false | This presumed domain is found C-terminal to a Rossmann-like domain suggesting that these proteins are oxidoreductases. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF10728"
] | [
"DUF2520"
] | [
9048
] | 1 | [] | [] | [] | 0 | [
"2i76",
"3d1l"
] | 2 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Siphoviridae sp. ctBLh2",
"unclassified sequences",
"uncultured marine thaumarchaeote AD1000_100_C06"
] | [
8838,
10,
1,
198,
1
] | 5 | [] | [] | 0 | true | Domain | Domain of unknown function DUF2520 | Domain of unknown function DUF2520 | DUF2520 | 5 |
IPR018932 | 18,932 | Salivary thrombin inhibitor anophelin, mosquito | Thrombin_inhibitor_anophelin | Family | 32 | false | false | This family represents Salivary thrombin inhibitor anophelin from Anopheles albimanus and similar proteins from insects. AT is a salivary protein with anticoagulant activity that inhibits host thrombin (F2), the peptidase that is at the end of the blood coagulation cascade and which creates the clot by cleaving fibrino... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF10731"
] | [
"Anophelin"
] | [
32
] | 1 | [] | [] | [] | 0 | [
"5nhu"
] | 1 | [
"PUB00044904",
"PUB00154982",
"PUB00154983"
] | [
"10460178",
"10600131",
"23223529"
] | [
"Purification, cloning, and synthesis of a novel salivary anti-thrombin from the mosquito Anopheles albimanus.",
"Anophelin: kinetics and mechanism of thrombin inhibition.",
"Unique thrombin inhibition mechanism by anophelin, an anticoagulant from the malaria vector."
] | [
1999,
1999,
2012
] | 3 | [] | [] | 0 | 0 | null | [
"Nematocera"
] | [
32
] | 1 | [] | [] | 0 | true | Family | Salivary thrombin inhibitor anophelin, mosquito | Salivary thrombin inhibitor anophelin, mosquito | Thrombin_inhibitor_anophelin | 1 |
IPR018933 | 18,933 | Netrin module, non-TIMP type | Netrin_module_non-TIMP | Domain | 18,912 | false | false | The netrin (NTR) module is an about 130-residue domain found in the C-terminal parts of netrins, complement proteins C3, C4, and C5, secreted frizzled-related proteins, and type I procollagen C-proteinase enhancer proteins (PCOLCEs), as well as in the N-terminal parts of tissue inhibitors of metalloproteinases (TIMPs).... | [] | [] | [] | 0 | [
"PFAM",
"SMART"
] | [
"PF01759",
"SM00643"
] | [
"NTR",
"C345C"
] | [
18868,
16051
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-173736",
"R-BTA-174577",
"R-BTA-198933",
"R-BTA-375276",
"R-BTA-381426",
"R-BTA-418594",
"R-BTA-6798695",
"R-BTA-8957275",
"R-BTA-977606",
"R-HSA-1650814",
"R-HSA-166663",
"R-HSA-166665",
"R-HSA-173736",
"R-HSA-174577",
"R-HSA-198933",
"R-HSA-201681",
"R-HSA-2243919",
"R-HSA... | [
"REACTOME:R-BTA-173736",
"REACTOME:R-BTA-174577",
"REACTOME:R-BTA-198933",
"REACTOME:R-BTA-375276",
"REACTOME:R-BTA-381426",
"REACTOME:R-BTA-418594",
"REACTOME:R-BTA-6798695",
"REACTOME:R-BTA-8957275",
"REACTOME:R-BTA-977606",
"REACTOME:R-HSA-1650814",
"REACTOME:R-HSA-166663",
"REACTOME:R-HSA-... | 62 | [
"1uap",
"1xwe",
"2a73",
"2a74",
"2i07",
"2ice",
"2icf",
"2qki",
"2wii",
"2win",
"2xwb",
"2xwj",
"3cu7",
"3frp",
"3g6j",
"3hrz",
"3hs0",
"3kls",
"3km9",
"3l3o",
"3l5n",
"3nms",
"3ohx",
"3prx",
"3pvm",
"3t4a",
"4a5w",
"4e0s",
"5fo7",
"5fo8",
"5fo9",
"5foa"... | 82 | [
"PUB00005058",
"PUB00018183"
] | [
"10452607",
"11274388"
] | [
"The NTR module: domains of netrins, secreted frizzled related proteins, and type I procollagen C-proteinase enhancer protein are homologous with tissue inhibitors of metalloproteases.",
"A human protein containing multiple types of protease-inhibitory modules."
] | [
1999,
2001
] | 2 | [
"IPR001134"
] | [
"IPR035811",
"IPR035813",
"IPR035814",
"IPR035815"
] | 1 | 4 | 0 | [
"Bacteria",
"Metazoa",
"bird metagenome"
] | [
8,
18903,
1
] | 3 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
50,
6,
55,
41,
56
] | 6 | true | Domain | Netrin module, non-TIMP type | Netrin module, non-TIMP type | Netrin_module_non-TIMP | 1 |
IPR018934 | 18,934 | RIO-type domain | RIO_dom | Domain | 19,440 | false | false | This entry represents the atypical serine/threonine kinase domain found in the RIO family members and similar proteins. RIO protein family are classified as atypical serine/threonine kinases and includes Rio1, Rio2 and Rio3, highly conserved from archaea to human [ ]. They exhibit little sequence similarity with eukary... | [
"GO:0003824",
"GO:0005524"
] | [
"catalytic activity",
"ATP binding"
] | [
"molecular_function",
"molecular_function"
] | 2 | [
"PFAM"
] | [
"PF01163"
] | [
"RIO1"
] | [
19440
] | 1 | [
"EC",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"2.7.11.1",
"R-BTA-6791226",
"R-HSA-6791226",
"R-MMU-6791226"
] | [
"EC:2.7.11.1",
"REACTOME:R-BTA-6791226",
"REACTOME:R-HSA-6791226",
"REACTOME:R-MMU-6791226"
] | 4 | [
"1tqi",
"1tqm",
"1tqp",
"1zao",
"1zar",
"1zp9",
"1ztf",
"1zth",
"2vwb",
"3en9",
"3enh",
"3re4",
"4gyg",
"4gyi",
"4jin",
"4otp",
"6eml",
"6fai",
"6fdm",
"6fdn",
"6fdo",
"6g18",
"6g51",
"6g5i",
"6hk6",
"6rbd",
"6y7c",
"6zv6",
"6zxd",
"6zxe",
"6zxf",
"6zxg"... | 45 | [
"PUB00031542",
"PUB00033361",
"PUB00059772",
"PUB00155945"
] | [
"15341724",
"16183636",
"19172740",
"31390939"
] | [
"Crystal structure of A. fulgidus Rio2 defines a new family of serine protein kinases.",
"A family portrait of the RIO kinases.",
"Structure of the archaeal Kae1/Bud32 fusion protein MJ1130: a model for the eukaryotic EKC/KEOPS subcomplex.",
"In vitro dimerization of human RIO2 kinase."
] | [
2004,
2005,
2008,
2019
] | 4 | [] | [
"IPR000687"
] | 0 | 1 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
2432,
4251,
12602,
5,
150
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
19,
4,
4,
4,
9,
15,
2,
7,
9,
2,
2,
32
] | 12 | true | Domain | RIO-type domain | RIO-type domain | RIO_dom | 9 |
IPR018935 | 18,935 | RIO kinase, conserved site | RIO_kinase_CS | Conserved_site | 12,791 | false | false | Protein phosphorylation, which plays a key role in most cellular activities, is a reversible process mediated by protein kinases and phosphoprotein phosphatases. Protein kinases catalyse the transfer of the gamma phosphate from nucleotide triphosphates (often ATP) to one or more amino acid residues in a protein substra... | [
"GO:0004674",
"GO:0005524"
] | [
"protein serine/threonine kinase activity",
"ATP binding"
] | [
"molecular_function",
"molecular_function"
] | 2 | [
"PROSITE"
] | [
"PS01245"
] | [
"RIO1"
] | [
12791
] | 1 | [
"EC",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"2.7.11.1",
"R-BTA-6791226",
"R-HSA-6791226",
"R-MMU-6791226"
] | [
"EC:2.7.11.1",
"REACTOME:R-BTA-6791226",
"REACTOME:R-HSA-6791226",
"REACTOME:R-MMU-6791226"
] | 4 | [
"1zp9",
"1ztf",
"1zth",
"3re4",
"4gyg",
"4gyi",
"4jin",
"4otp",
"6fdm",
"6fdn",
"6fdo",
"6g18",
"6g51",
"6g5i",
"6hk6",
"6zv6",
"6zxd",
"6zxe",
"6zxf",
"6zxg",
"6zxh",
"7vbt",
"7wu0",
"8zdb",
"8zdc",
"8zdd",
"9f81"
] | 27 | [
"PUB00005115",
"PUB00015362",
"PUB00020114",
"PUB00033361",
"PUB00034898",
"PUB00034899"
] | [
"3291115",
"12368087",
"12471243",
"16183636",
"15078142",
"15320712"
] | [
"The protein kinase family: conserved features and deduced phylogeny of the catalytic domains.",
"Evolution of protein kinase signaling from yeast to man.",
"The protein kinase complement of the human genome.",
"A family portrait of the RIO kinases.",
"High-throughput structural biology in drug discovery: p... | [
1988,
2002,
2002,
2005,
2004,
2004
] | 6 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"ecological metagenomes"
] | [
864,
2340,
9527,
60
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
13,
3,
4,
3,
8,
13,
2,
4,
9,
1,
2,
11
] | 12 | true | Conserved_site | RIO kinase, conserved site | RIO kinase, conserved site | RIO_kinase_CS | 8 |
IPR018936 | 18,936 | Phosphatidylinositol 3-/4-kinase, conserved site | PI3/4_kinase_CS | Conserved_site | 48,381 | false | false | Phosphatidylinositol 3-kinase (PI3-kinase) ( ) [ ] is an enzyme that phosphorylates phosphoinositides on the 3-hydroxyl group of the inositol ring. The three products of PI3-kinase - PI-3-P, PI-3,4-P(2) and PI-3,4,5-P(3) function as secondary messengers in cell signalling. Phosphatidylinositol 4-kinase (PI4-kinase) ( )... | [
"GO:0016301"
] | [
"kinase activity"
] | [
"molecular_function"
] | 1 | [
"PROSITE",
"PROSITE"
] | [
"PS00915",
"PS00916"
] | [
"PI3_4_KINASE_1",
"PI3_4_KINASE_2"
] | [
35296,
43528
] | 2 | [
"EC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
... | [
"2.7.1",
"R-BTA-109704",
"R-BTA-112399",
"R-BTA-114604",
"R-BTA-1250342",
"R-BTA-1257604",
"R-BTA-1433557",
"R-BTA-1660499",
"R-BTA-180292",
"R-BTA-186763",
"R-BTA-1963642",
"R-BTA-198203",
"R-BTA-201556",
"R-BTA-202424",
"R-BTA-2029485",
"R-BTA-210993",
"R-BTA-2424491",
"R-BTA-273... | [
"EC:2.7.1",
"REACTOME:R-BTA-109704",
"REACTOME:R-BTA-112399",
"REACTOME:R-BTA-114604",
"REACTOME:R-BTA-1250342",
"REACTOME:R-BTA-1257604",
"REACTOME:R-BTA-1433557",
"REACTOME:R-BTA-1660499",
"REACTOME:R-BTA-180292",
"REACTOME:R-BTA-186763",
"REACTOME:R-BTA-1963642",
"REACTOME:R-BTA-198203",
... | 419 | [
"1e7u",
"1e7v",
"1e8w",
"1e8x",
"1e8y",
"1e8z",
"1e90",
"1he8",
"2a4z",
"2a5u",
"2chw",
"2chx",
"2chz",
"2rd0",
"2v4l",
"2wxf",
"2wxg",
"2wxh",
"2wxi",
"2wxj",
"2wxk",
"2wxl",
"2wxm",
"2wxn",
"2wxo",
"2wxp",
"2wxq",
"2wxr",
"2x38",
"2x6f",
"2x6h",
"2x6i"... | 500 | [
"PUB00000875",
"PUB00000893",
"PUB00001254",
"PUB00007087",
"PUB00014536",
"PUB00090062"
] | [
"1322797",
"8387896",
"8194527",
"12151228",
"12456783",
"24675427"
] | [
"Phosphatidylinositol 3-kinase: structure and expression of the 110 kd catalytic subunit.",
"Target of rapamycin in yeast, TOR2, is an essential phosphatidylinositol kinase homolog required for G1 progression.",
"PIK1, an essential phosphatidylinositol 4-kinase associated with the yeast nucleus.",
"Structural... | [
1992,
1993,
1994,
2002,
2002,
2014
] | 6 | [] | [] | 0 | 0 | null | [
"Bacillati",
"Eukaryota",
"Viruses",
"metagenomes"
] | [
10,
48354,
9,
8
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
45,
6,
49,
24,
78,
49,
6,
25,
65,
8,
8,
95
] | 12 | true | Conserved_site | Phosphatidylinositol 3-/4-kinase, conserved site | Phosphatidylinositol 3-/4-kinase, conserved site | PI3/4_kinase_CS | 9 |
IPR018937 | 18,937 | Membrane magnesium transporter | MMgT | Family | 3,179 | false | false | This entry represents a family of membrane magnesium transporters (MMgT) [ ]. The proteins, MMgT1 (also known as ER membrane protein complex subunit 5) and MMgT2, are localised to the Golgi complex and post-Golgi vesicles, including the early endosomes, suggesting that they may provide regulated pathways for Mg2+ trans... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF10270"
] | [
"MMgT"
] | [
3179
] | 1 | [
"REACTOME"
] | [
"R-HSA-5223345"
] | [
"REACTOME:R-HSA-5223345"
] | 1 | [
"6wb9",
"6ww7",
"6z3w",
"7ado",
"7adp",
"7kra",
"7ktx",
"8eoi",
"8j0n",
"8j0o",
"8s9s",
"9c7v"
] | 12 | [
"PUB00044888",
"PUB00096678",
"PUB00096679",
"PUB00096680",
"PUB00096681",
"PUB00096682"
] | [
"18057121",
"30415835",
"29809151",
"29242231",
"32459176",
"32439656"
] | [
"Identification and characterization of a novel family of membrane magnesium transporters, MMgT1 and MMgT2.",
"EMC Is Required to Initiate Accurate Membrane Protein Topogenesis.",
"The ER membrane protein complex interacts cotranslationally to enable biogenesis of multipass membrane proteins.",
"The ER membra... | [
2008,
2018,
2018,
2018,
2020,
2020
] | 6 | [] | [] | 0 | 0 | null | [
"Candidatus Enterococcus willemsii",
"Eukaryota"
] | [
1,
3178
] | 2 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
4,
1,
1,
1,
2,
2,
1,
2,
5,
1,
1,
8
] | 12 | true | Family | Membrane magnesium transporter | Membrane magnesium transporter | MMgT | 5 |
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