LiteFold/InterPro · Datasets at Hugging Face

IPR021012

21,012

Cell adhesion molecule Dscam1, C-terminal

Dscam1_C

Domain

2,226

false

This entry is specific to the insecta, predominantly Drosophila spp. This entry is found in association with , and . The Cell adhesion molecule Dscam1 (also known as Down syndrome cell adhesion molecule) belongs to a family of cell membrane molecules involved in the differentiation of the nervous system. This is the C-...

[]

0

[ "PFAM" ]

[ "PF12355" ]

[ "Dscam_C" ]

[ 2226 ]

1

[ "REACTOME" ]

[ "R-DME-376172" ]

[ "REACTOME:R-DME-376172" ]

1

[]

0

[ "PUB00053403" ]

[ "18403399" ]

[ "The Dscam homologue of the crustacean Daphnia is diversified by alternative splicing like in insects." ]

[ 2008 ]

1

[]

0

null

[ "Pancrustacea" ]

[ 2226 ]

1

[ "Drosophila melanogaster" ]

[ 63 ]

1

true

Domain

Cell adhesion molecule Dscam1, C-terminal

Dscam1_C

8

IPR021013

21,013

ATPase, vacuolar ER assembly factor, Vma12

ATPase_Vma12

Family

4,129

false

Transmembrane ATPases are membrane-bound enzyme complexes/ion transporters that use ATP hydrolysis to drive the transport of protons across a membrane. Some transmembrane ATPases also work in reverse, harnessing the energy from a proton gradient, using the flux of ions across the membrane via the ATPase proton channel ...

[ "GO:0070072" ]

[ "vacuolar proton-transporting V-type ATPase complex assembly" ]

[ "biological_process" ]

1

[ "PFAM", "PANTHER" ]

[ "PF11712", "PTHR31394" ]

[ "Vma12", "" ]

[ 3640, 3866 ]

2

[]

0

[ "8eat" ]

1

[ "PUB00020603", "PUB00020604", "PUB00020608", "PUB00020609", "PUB00053289", "PUB00068786", "PUB00068787", "PUB00068788", "PUB00068789" ]

[ "15473999", "15078220", "15907459", "15629643", "10340847", "20450191", "18937357", "1385979", "9741106" ]

[ "The evolution of A-, F-, and V-type ATP synthases and ATPases: reversals in function and changes in the H+/ATP coupling ratio.", "Mechanisms of ATPases--a multi-disciplinary approach.", "A new view of an old pore.", "A structural model of the vacuolar ATPase from transmission electron microscopy.", "Assemb...

[ 2004, 2004, 2005, 2005, 1999, 2010, 2008, 1992, 1998 ]

9

[]

0

null

[ "Bhargavaea changchunensis", "Eukaryota" ]

[ 1, 4128 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 6, 1, 2, 1, 6, 4, 1, 3, 3, 1, 1, 4 ]

12

true

Family

ATPase, vacuolar ER assembly factor, Vma12

ATPase_Vma12

8

IPR021014

21,014

SidE, PDE domain

SidE_PDE

Domain

261

false

This entry represents the phosphodiesterase (PDE) domain from the SidE family of proteins found in the Dot/Icm pathway of Legionella pneumophila bacteria. This domain catalyses the conjugation of ADP-ribosylated ubiquitin (ADPR-Ub), previously synthesised by the mono-ADP-ribosyltransferase (mART) domain, to a serine re...

[]

0

[ "PFAM" ]

[ "PF12252" ]

[ "SidE_PDE" ]

[ 261 ]

1

[]

0

[ "5bq9", "5bu0", "5bu1", "5bu2", "5t8b", "5t8c", "5yij", "5yik", "5yim", "5zq2", "5zq3", "5zq4", "5zq5", "5zq6", "5zq7", "6b7m", "6b7o", "6b7p", "6b7q", "6g0c", "6rya", "6ryb", "7mir", "7mis", "7ppo", "7pqe", "9emk", "9fgj", "9fgm" ]

29

[ "PUB00094380", "PUB00094381", "PUB00094398", "PUB00094399", "PUB00094400", "PUB00094401", "PUB00098613", "PUB00098614" ]

[ "29731171", "29795346", "26598703", "27912065", "22524316", "11017125", "27049943", "30428531" ]

[ "Structural Insights into Non-canonical Ubiquitination Catalyzed by SidE.", "Mechanism of phosphoribosyl-ubiquitination mediated by a single Legionella effector.", "Structural basis of substrate recognition by a bacterial deubiquitinase important for dynamics of phagosome ubiquitination.", "Phosphoribosylatio...

[ 2018, 2018, 2015, 2016, 2012, 2000, 2016, 2018 ]

8

[]

0

null

[ "Bacteria", "Eukaryota" ]

[ 243, 18 ]

2

[]

0

true

Domain

SidE, PDE domain

SidE_PDE

7

IPR021015

21,015

Duffy-antigen binding, C-terminal

Duffy-antigen-binding_C

Domain

105

false

This domain is located at the C-terminal of the Duffy-antigen binding protein of Plasmodium spp. Duffy-antigen binding protein is an antigen on these parasites which enable them to invade erythrocytes [ ]. Proteins containing this domain are typically between 449 and 1061 amino acids in length. These proteins are found...

[ "GO:0016020" ]

[ "membrane" ]

[ "cellular_component" ]

1

[ "PFAM" ]

[ "PF12361" ]

[ "DBP" ]

[ 105 ]

1

[]

0

[]

0

[ "PUB00053362" ]

[ "11441501" ]

[ "Analysis of polymorphic regions of Plasmodium vivax Duffy binding protein of Korean isolates." ]

[ 2001 ]

1

[]

0

null

[ "Plasmodium" ]

[ 105 ]

1

[]

0

true

Domain

Duffy-antigen binding, C-terminal

Duffy-antigen-binding_C

6

IPR021016

21,016

Beta-1,3-xylanase

Beta-xylanase

Family

56

false

Many glycoside hydrolases are modular proteins composed of catalytic modules appended to one or more non-catalytic carbohydrate-binding modules (CBMs). CBMs bind to a range of polysaccharides that include crystalline cellulose and hemicelluloses such as glucan, xylan, mannan, and glucomannan. The main function of CBMs ...

[ "GO:0033905" ]

[ "xylan endo-1,3-beta-xylosidase activity" ]

[ "molecular_function" ]

1

[ "PFAM" ]

[ "PF11606" ]

[ "AlcCBM31" ]

[ 56 ]

1

[ "EC", "METACYC" ]

[ "3.2.1.32", "PWY-6789" ]

[ "EC:3.2.1.32", "METACYC:PWY-6789" ]

2

[ "2cov" ]

1

[ "PUB00040083", "PUB00054181" ]

[ "16061225", "10742274" ]

[ "The first crystal structure of a family 31 carbohydrate-binding module with affinity to beta-1,3-xylan.", "Cloning, sequencing, and expression in Escherichia coli of the new gene encoding beta-1,3-xylanase from a marine bacterium, Vibrio sp. strain XY-214." ]

[ 2005, 2000 ]

2

[]

0

null

[ "Pseudomonadati" ]

[ 56 ]

1

[]

0

true

Family

Beta-1,3-xylanase

Beta-xylanase

6

IPR021017

21,017

Mediator complex, subunit Med2, fungi

Mediator_Med2_fun

Family

166

false

The Mediator complex is a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. The Mediator complex, having a compact confor...

[]

0

[ "PFAM" ]

[ "PF11214" ]

[ "Med2" ]

[ 166 ]

1

[]

0

[ "7uic", "7uik", "7uil", "7uio" ]

4

[ "PUB00033372", "PUB00053361" ]

[ "15175151", "14988503" ]

[ "A unified nomenclature for protein subunits of mediator complexes linking transcriptional regulators to RNA polymerase II.", "Site-specific Srb10-dependent phosphorylation of the yeast Mediator subunit Med2 regulates gene expression from the 2-microm plasmid." ]

[ 2004, 2004 ]

2

[]

0

null

[ "Dikarya" ]

[ 166 ]

1

[ "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)" ]

[ 1 ]

1

true

Family

Mediator complex, subunit Med2, fungi

Mediator_Med2_fun

7

IPR021018

21,018

Mediator complex, subunit Med29, metazoa

Mediator_Med29_met

Family

1,173

false

The Mediator complex is a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. The Mediator complex, having a compact confor...

[ "GO:0016592" ]

[ "mediator complex" ]

[ "cellular_component" ]

1

[ "PFAM", "PANTHER" ]

[ "PF11568", "PTHR28314" ]

[ "Med29", "" ]

[ 1161, 1059 ]

2

[ "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-1989781", "R-HSA-381340", "R-HSA-9833110" ]

[ "REACTOME:R-HSA-1989781", "REACTOME:R-HSA-381340", "REACTOME:R-HSA-9833110" ]

3

[ "6w1s", "7emf", "7ena", "7enc", "7enj", "7lbm", "8gxq", "8gxs", "8t1i", "8t1l", "8t9d", "8tqw", "8trh" ]

13

[ "PUB00053290" ]

[ "15896743" ]

[ "The mammalian Mediator complex and its role in transcriptional regulation." ]

[ 2005 ]

1

[]

0

null

[ "Eukaryota" ]

[ 1173 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 2, 2, 8, 1, 1 ]

6

true

Family

Mediator complex, subunit Med29, metazoa

Mediator_Med29_met

4

IPR021019

21,019

Mediator complex, subunit Med30, metazoa

Mediator_Med30_met

Family

1,812

false

The Mediator complex is a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. The Mediator complex, having a compact confor...

[]

0

[ "PFAM", "PANTHER" ]

[ "PF11315", "PTHR31705" ]

[ "Med30", "" ]

[ 1812, 1734 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-212436", "R-BTA-9841922", "R-DME-9841922", "R-HSA-1989781", "R-HSA-212436", "R-HSA-381340", "R-HSA-9833110", "R-HSA-9841922" ]

[ "REACTOME:R-BTA-212436", "REACTOME:R-BTA-9841922", "REACTOME:R-DME-9841922", "REACTOME:R-HSA-1989781", "REACTOME:R-HSA-212436", "REACTOME:R-HSA-381340", "REACTOME:R-HSA-9833110", "REACTOME:R-HSA-9841922" ]

8

[ "6w1s", "7emf", "7ena", "7enc", "7enj", "7lbm", "7nvr", "8gxq", "8gxs", "8t1i", "8t1l", "8t9d", "8tqw", "8trh" ]

14

[ "PUB00053360" ]

[ "11909976" ]

[ "Requirement of TRAP/mediator for both activator-independent and activator-dependent transcription in conjunction with TFIID-associated TAF(II)s." ]

[ 2002 ]

1

[]

0

null

[ "Eukaryota" ]

[ 1812 ]

1

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 3, 1, 1, 1, 4 ]

5

true

Family

Mediator complex, subunit Med30, metazoa

Mediator_Med30_met

6

IPR021020

21,020

Adhesin, Dr family, signal peptide

Adhesin_Dr_signal_peptide

PTM

63

false

The Afa/Dr family of adhesins bind to the Dr blood group antigen component of decay-accelerating factor. These proteins contain both fimbriated and afimbriated adherence structures and mediate adherence of uropathogenic Escherichia coli to the urinary tract, leading to urinary tract infections (UTIs) and pregnancy comp...

[]

0

[ "PFAM" ]

[ "PF12393" ]

[ "Dr_adhesin" ]

[ 63 ]

1

[]

0

[]

0

[ "PUB00008499", "PUB00008500", "PUB00099772", "PUB00099773" ]

[ "9169726", "1670929", "25278576", "31917805" ]

[ "Distribution of drb genes coding for Dr binding adhesins among uropathogenic and fecal Escherichia coli isolates and identification of new subtypes.", "Molecular structure of the Dr adhesin: nucleotide sequence and mapping of receptor-binding domain by use of fusion constructs.", "Pathogenesis of human diffuse...

[ 1997, 1991, 2014, 2020 ]

4

[]

0

null

[ "Escherichia coli" ]

[ 63 ]

1

[]

0

true

PTM

Adhesin, Dr family, signal peptide

Adhesin_Dr_signal_peptide

5

IPR021021

21,021

Fibronectin-binding repeat, SSURE

Fibronectin-binding_SSURE

Repeat

399

false

Streptococcal surface repeat domain - SSURE - is a protein fragment found to bind to extracellular matrix protein fibronectin but not to collagen or submaxillary mucin in Streptococci. Anti-SSURE antibodies recognised the corresponding protein on the surface of streptococcal cells. The full-length proteins are thus fib...

[]

0

[ "PFAM" ]

[ "PF11966" ]

[ "SSURE" ]

[ 399 ]

1

[]

0

[]

0

[ "PUB00053291" ]

[ "15703481" ]

[ "Sequence analysis and characterization of a novel fibronectin-binding repeat domain from the surface of Streptococcus pneumoniae." ]

[ 2004 ]

1

[]

0

null

[ "Bacteria", "human gut metagenome" ]

[ 396, 3 ]

2

[]

0

true

Repeat

Fibronectin-binding repeat, SSURE

Fibronectin-binding_SSURE

3

IPR021022

21,022

Human herpes virus-8, Protein K1, cytoplasmic domain

HHSV-8_K1_cytoplasmic_dom

Domain

1,853

false

This entry represents a domain thought to to be at the cytoplasmic region of the Protein K1 from Human herpesvirus 8. This protein promotes host cell survival pathways and may contribute to pathogenesis by preventing infected cells from undergoing apoptosis. It is a highly glycosylated cytoplasmic and membrane protein ...

[]

0

[ "PFAM" ]

[ "PF11049" ]

[ "KSHV_K1" ]

[ 1853 ]

1

[]

0

[]

0

[ "PUB00019758", "PUB00099863", "PUB00099864", "PUB00099865", "PUB00099866" ]

[ "10196312", "9710606", "14747556", "10318948", "15665117" ]

[ "High-level variability in the ORF-K1 membrane protein gene at the left end of the Kaposi's sarcoma-associated herpesvirus genome defines four major virus subtypes and multiple variants or clades in different human populations.", "Identification of an immunoreceptor tyrosine-based activation motif of K1 transform...

[ 1999, 1998, 2004, 1999, 2005 ]

5

[]

0

null

[ "Human herpesvirus 8" ]

[ 1853 ]

1

[]

0

true

Domain

Human herpes virus-8, Protein K1, cytoplasmic domain

HHSV-8_K1_cytoplasmic_dom

9

IPR021023

21,023

Envelope glycoprotein UL132

UL132

Family

121

false

Envelope glycoprotein UL132 is a low-abundance structural component of Human Cytomegalovirus [ ]. UL132 has an important function for viral replication in tissue culture [ ]. It is essential for the formation of the viral assembly compartment (AC), hence, critical for the efficient production of infectious particles [ ...

[]

0

[ "PFAM" ]

[ "PF11359" ]

[ "gpUL132" ]

[ 121 ]

1

[ "REACTOME", "REACTOME" ]

[ "R-HSA-9609690", "R-HSA-9610379" ]

[ "REACTOME:R-HSA-9609690", "REACTOME:R-HSA-9610379" ]

2

[]

0

[ "PUB00053292", "PUB00099798", "PUB00099799" ]

[ "17053313", "16140760", "32994323" ]

[ "Genetic variability of human cytomegalovirus UL132 gene in strains from infected infants.", "Deletion of gpUL132, a structural component of human cytomegalovirus, results in impaired virus replication in fibroblasts.", "Human Cytomegalovirus Envelope Protein gpUL132 Regulates Infectious Virus Production throug...

[ 2006, 2005, 2020 ]

3

[]

0

null

[ "Cytomegalovirus" ]

[ 121 ]

1

[]

0

true

Family

Envelope glycoprotein UL132

UL132

5

IPR021025

21,025

Fanconi Anaemia group E protein, C-terminal

Fanconi_anaemia_gr_E_prot_C

Domain

1,233

false

Fanconi Anaemia (FA) is a cancer predisposition disorder characterised by chromosome fragility and hypersensitivity to genotoxic agents that suggest defects in the molecular mechanisms of DNA damage signalling and repair. In response to DNA damage, the FA core complex monoubiquitinates the FANCD2 protein. This ubiquiti...

[]

0

[ "PFAM", "CDD" ]

[ "PF11510", "cd07439" ]

[ "FA_FANCE", "FANCE_c-term" ]

[ 1205, 552 ]

2

[ "REACTOME", "REACTOME" ]

[ "R-HSA-6783310", "R-HSA-9833482" ]

[ "REACTOME:R-HSA-6783310", "REACTOME:R-HSA-9833482" ]

2

[ "2ilr", "7kzp", "7kzq", "7kzr", "7kzs", "7kzt", "7kzv" ]

7

[ "PUB00041735" ]

[ "17308347" ]

[ "Insights into Fanconi Anaemia from the structure of human FANCE." ]

[ 2007 ]

1

[]

0

null

[ "Eukaryota" ]

[ 1233 ]

1

[ "Arabidopsis thaliana", "Danio rerio", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus" ]

[ 5, 1, 5, 12, 2, 5 ]

6

true

Domain

Fanconi Anaemia group E protein, C-terminal

Fanconi_anaemia_gr_E_prot_C

2

IPR021026

21,026

Filamentous haemagglutinin family outer membrane protein, domain of unknown function DUF3739

Filamn_hemagglutn_DUF3739

Domain

1,101

false

This entry represents a conserved sequence domain found in a number of bacterial filamentous haemagglutinins, usually in association with .

[]

0

[ "PFAM" ]

[ "PF12545" ]

[ "DUF3739" ]

[ 1101 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Eukaryota", "Pseudomonadati", "metagenomes" ]

[ 5, 1056, 40 ]

3

[]

0

true

Domain

Filamentous haemagglutinin family outer membrane protein, domain of unknown function DUF3739

Filamn_hemagglutn_DUF3739

3

IPR021027

21,027

Transposase, putative, helix-turn-helix domain

Transposase_put_HTH

Domain

21,935

false

This entry represents an N-terminal helix-turn-helix domain found in a variety of putative transposases [ , , ], such as A625R from Paramecium bursaria Chlorella virus 1 and in RNA-guided DNA endonucleases, including TnpB from Deinococcus radiodurans, an RNA-guided dsDNA endonuclease that cleaves DNA downstream of the ...

[]

0

[ "PFAM" ]

[ "PF12323" ]

[ "HTH_OrfB_IS605" ]

[ 21935 ]

1

[]

0

[ "8bf8", "8ex9", "8exa", "8h1j", "8iaz", "9j09", "9jfo", "9jfp", "9jfq", "9udi" ]

10

[ "PUB00001825", "PUB00001858", "PUB00002091", "PUB00100808" ]

[ "8386127", "7557457", "2553665", "34619744" ]

[ "IS1136, an insertion element in the erythromycin gene cluster of Saccharopolyspora erythraea.", "A novel insertion sequence (IS)-like element of the thermophilic bacterium PS3 promotes expression of the alanine carrier protein-encoding gene.", "Characterization of an insertion sequence (IS891) of novel structu...

[ 1993, 1995, 1989, 2021 ]

4

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 1095, 20102, 313, 176, 249 ]

5

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Domain

Transposase, putative, helix-turn-helix domain

Transposase_put_HTH

3

IPR021028

21,028

Homotrimeric ring hydroxylase, catalytic domain

Homotrim_ring_OHase_catalytic

Domain

386

false

This entry represents the catalytic domain from a family of homotrimeric enzymes that hydroxylate aromatic compounds, including carbazole 1,9a-dioxygenase from Janthinobacterium. The catalytic domain is found C-termnial to the iron-sulphur-binding Rieske domain and is composed of antiparallel β sheets and α helices [ ]...

[]

0

[ "PFAM" ]

[ "PF11723" ]

[ "Aromatic_hydrox" ]

[ 386 ]

1

[]

0

[ "1ww9", "1z01", "1z02", "1z03", "2de5", "2de6", "2de7", "3gcf", "3gkq", "3vmg", "3vmh", "3vmi", "4nb8", "4nb9", "4nba", "4nbb", "4nbc", "4nbd", "4nbe", "4nbf", "4nbg", "4nbh", "6ll0", "6ll1", "6ll4", "6llf", "6llh", "6llk", "6llm", "7bug", "7bui" ]

31

[ "PUB00038166", "PUB00053295" ]

[ "16005887", "18922149" ]

[ "Structure of the terminal oxygenase component of angular dioxygenase, carbazole 1,9a-dioxygenase.", "The Bet v 1 fold: an ancient, versatile scaffold for binding of large, hydrophobic ligands." ]

[ 2005, 2008 ]

2

[]

0

null

[ "Bacteria", "Geodia barretti", "ecological metagenomes" ]

[ 379, 1, 6 ]

3

[]

0

true

Domain

Homotrimeric ring hydroxylase, catalytic domain

Homotrim_ring_OHase_catalytic

2

IPR021029

21,029

DNA polymerase III, tau subunit, domain V

DNA_pol_III_tau_dom-5

Domain

6,102

false

This domain family is found in bacteria, and is approximately 140 amino acids in length. It is found in association with . Domains I-III are shared between the tau and the gamma subunits, while most of the DnaB-binding Domain IV and all of the alpha-interacting Domain V are unique to tau. The extreme C-terminal region ...

[ "GO:0003887" ]

[ "DNA-directed DNA polymerase activity" ]

[ "molecular_function" ]

1

[ "PFAM" ]

[ "PF12170" ]

[ "DNA_pol3_tau_5" ]

[ 6102 ]

1

[ "EC" ]

[ "2.7.7.7" ]

[ "EC:2.7.7.7" ]

1

[ "2aya", "5fku", "5fkv", "8gj0", "8gj1", "8gj2", "8gj3" ]

7

[ "PUB00053293", "PUB00053294" ]

[ "11078743", "17355988" ]

[ "tau binds and organizes Escherichia coli replication through distinct domains. Partial proteolysis of terminally tagged tau to determine candidate domains and to assign domain V as the alpha binding domain.", "The unstructured C-terminus of the tau subunit of Escherichia coli DNA polymerase III holoenzyme is the...

[ 2001, 2007 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 5999, 11, 92 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Domain

DNA polymerase III, tau subunit, domain V

DNA_pol_III_tau_dom-5

7

IPR021030

21,030

Protein of unknown function DUF3731

DUF3731

Family

1,280

false

Proteins in this family are bacterial proteins of approximately 250 amino acids in length. There are two conserved sequence motifs: RPG and WRR. The proteins in this family are frequently annotated as DNA-K related proteins however there is little accompanying literature to confirm this.

[]

0

[ "PFAM" ]

[ "PF12531" ]

[ "DUF3731" ]

[ 1280 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Candidatus Methanogaster sp. ANME-2c ERB4", "Oikopleura dioica", "metagenomes" ]

[ 1275, 1, 1, 3 ]

4

[]

0

true

Family

Protein of unknown function DUF3731

DUF3731

9

IPR021031

21,031

Hyphally-regulated cell wall protein, N-terminal

Hyphal-reg_cell_wall_N

Domain

745

false

This entry represents a conserved domain found at the N terminus of a number of fungal proteins. These proteins are largely annotated as being hyphally-regulated cell wall proteins that are induced in response to hyphal development. Proteins containing this domain include Hpf1 from budding yeasts and Hyr1 from Candida ...

[]

0

[ "PFAM" ]

[ "PF11765" ]

[ "Hyphal_reg_CWP" ]

[ 745 ]

1

[]

0

[]

0

[ "PUB00075447", "PUB00075448", "PUB00075449" ]

[ "17024473", "22028796", "21283544" ]

[ "Reducing haziness in white wine by overexpression of Saccharomyces cerevisiae genes YOL155c and YDR055w.", "Active and passive immunization with rHyr1p-N protects mice against hematogenously disseminated candidiasis.", "Role of Bcr1-activated genes Hwp1 and Hyr1 in Candida albicans oral mucosal biofilms and ne...

[ 2007, 2011, 2011 ]

3

[]

0

null

[ "Alphaproteobacteria", "Opisthokonta" ]

[ 21, 724 ]

2

[ "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)" ]

[ 2 ]

1

true

Domain

Hyphally-regulated cell wall protein, N-terminal

Hyphal-reg_cell_wall_N

4

IPR021033

21,033

Extracellular fibrinogen binding protein, C-terminal

Extracellular_fibrinogen-bd_C

Domain

65

false

This entry represents the C-terminal region of bacterial extracellular fibrinogen binding proteins which is approximately 70 amino acids in length and contains a conserved VLK sequence motif. It also contains a helical motif involved in complement regulation [ ]. This motif binds to complement proteins and changes its ...

[ "GO:0001848", "GO:0005615" ]

[ "complement binding", "extracellular space" ]

[ "molecular_function", "cellular_component" ]

2

[ "PFAM" ]

[ "PF12199" ]

[ "efb-c" ]

[ 65 ]

1

[]

0

[ "2gom", "2gox", "2noj", "3d5r", "3d5s" ]

5

[ "PUB00041129" ]

[ "17351618" ]

[ "A structural basis for complement inhibition by Staphylococcus aureus." ]

[ 2007 ]

1

[]

0

null

[ "Staphylococcaceae" ]

[ 65 ]

1

[]

0

true

Domain

Extracellular fibrinogen binding protein, C-terminal

Extracellular_fibrinogen-bd_C

1

IPR021034

21,034

Tip attachment protein J, C-terminal receptor binding domain

GpJ_C

Domain

1,181

false

This entry represents the C-terminal receptor binding domain of Tip attachment protein J from Escherichia phage lambda (GpJ) and similar bacterial and viral proteins. This domain, which determines the host specificity of the phage, shows an immunoglobulin-like fold [ , ]. It is often found in association with and . The...

[]

0

[ "PFAM" ]

[ "PF12421" ]

[ "Ig_GpJ_C" ]

[ 1181 ]

1

[]

0

[ "8iyk", "8iyl", "8k35", "8xcg", "8xci", "8xcj", "8xck" ]

7

[ "PUB00075602", "PUB00075672", "PUB00109155", "PUB00155963", "PUB00156051" ]

[ "6228546", "23542343", "10629200", "38760367", "16489764" ]

[ "Proteinase sensitivity of bacteriophage lambda tail proteins gpJ and pH in complexes with the lambda receptor.", "Tail tip proteins related to bacteriophage λ gpL coordinate an iron-sulfur cluster.", "The C-terminal portion of the tail fiber protein of bacteriophage lambda is responsible for binding to LamB, i...

[ 1984, 2013, 2000, 2024, 2006 ]

5

[]

0

null

[ "Bacteria", "Caudoviricetes", "Ecdysozoa", "human gut metagenome" ]

[ 1151, 27, 2, 1 ]

4

[]

0

true

Domain

Tip attachment protein J, C-terminal receptor binding domain

GpJ_C

1

IPR021035

21,035

Glycoprotein 60, Cryptosporidium spp

Glycop-60_Cryptosporidium

Domain

2,691

false

This entry represents proteins that are highly conserved in Cryptosporidium spp. Many members are annotated as being a 60kDa glycoprotein.

[]

0

[ "PFAM" ]

[ "PF11025" ]

[ "GP40" ]

[ 2691 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Actinacidiphila yanglinensis", "Eukaryota" ]

[ 1, 2690 ]

2

[]

0

true

Domain

Glycoprotein 60, Cryptosporidium spp

Glycop-60_Cryptosporidium

8

IPR021036

21,036

Small ribosomal subunit protein mS45

Ribosomal_mS45

Family

1,695

false

This entry represents the small ribosomal subunit protein mS45, also known as Ribosomal protein S35, which localises to the mitochondria in live cells and co-fractionates with purified mitochondrial ribosomes. This group of proteins have a function in the control of cell respiration by acting on the mitochondrial prote...

[]

0

[ "PANTHER" ]

[ "PTHR28158" ]

[ "" ]

[ 1695 ]

1

[]

0

[ "5mrc", "5mre", "5mrf", "6yw5", "6ywe", "6ywx", "6ywy", "8d8j", "8d8k", "8d8l", "8om2", "8om3", "8om4" ]

13

[ "PUB00053299" ]

[ "18245278" ]

[ "Bot1p is required for mitochondrial translation, respiratory function, and normal cell morphology in the fission yeast Schizosaccharomyces pombe." ]

[ 2008 ]

1

[]

0

null

[ "Eukaryota" ]

[ 1695 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 1, 1 ]

3

true

Family

Small ribosomal subunit protein mS45

Ribosomal_mS45

4

IPR021037

21,037

Stomoxyn

Family

8

false

Stomoxyn is an insect antimicrobial peptide localised in the gut epithelium, which functions in killing a range of microorganisms, parasites and some viruses. In water, stomoxyn has a flexible random coil in structure, while in trifluoroethanol it adopts a stable helical structure. Structural similarities to the antimi...

[ "GO:0042742", "GO:0050832" ]

[ "defense response to bacterium", "defense response to fungus" ]

[ "biological_process", "biological_process" ]

2

[ "PFAM" ]

[ "PF11585" ]

[ "Stomoxyn" ]

[ 8 ]

1

[]

0

[ "1zrx" ]

1

[ "PUB00038995" ]

[ "16170803" ]

[ "Solution structures of stomoxyn and spinigerin, two insect antimicrobial peptides with an alpha-helical conformation." ]

[ 2006 ]

1

[]

0

null

[ "Calyptratae" ]

[ 8 ]

1

[]

0

true

Family

Stomoxyn

3

IPR021040

21,040

LRRC8, pannexin-like TM region

LRRC8_Pannexin-like

Domain

4,745

false

This entry represents the four transmembrane domains of metazoan leucine-rich-repeat-containing 8 proteins. These four TMs associate into hexamers resulting in homo- or heteromeric channels that connect the cytosol to the extracellular space [ ].

[]

0

[ "PFAM" ]

[ "PF12534" ]

[ "Pannexin_like" ]

[ 4745 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-5223345", "R-HSA-5223345", "R-MMU-5223345", "R-RNO-5223345" ]

[ "REACTOME:R-BTA-5223345", "REACTOME:R-HSA-5223345", "REACTOME:R-MMU-5223345", "REACTOME:R-RNO-5223345" ]

4

[ "5zsu", "6djb", "6g8z", "6g9l", "6g9o", "6m04", "6nzw", "6nzz", "6o00", "7m17", "7m19", "7p5v", "7p5w", "7p5y", "7p60", "7p6k", "7xzh", "8b40", "8b41", "8b42", "8dr8", "8dra", "8dre", "8drk", "8drn", "8dro", "8drq", "8ds3", "8ds9", "8dsa", "8dxn", "8dxo"...

48

[ "PUB00075689" ]

[ "22532330" ]

[ "LRRC8 proteins share a common ancestor with pannexins, and may form hexameric channels involved in cell-cell communication." ]

[ 2012 ]

1

[]

0

null

[ "Eumetazoa", "Flaviramulus basaltis" ]

[ 4744, 1 ]

2

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 13, 28, 15, 11 ]

4

true

Domain

LRRC8, pannexin-like TM region

LRRC8_Pannexin-like

3

IPR021041

21,041

Major surface glycoprotein 2, C-terminal

Maj_surf_glycoprot_2_C

Domain

295

false

Pneumocystis can cause potentially fatal pneumonia infections in immunosuppressed people. The most abundant protein on the surface of Pneumocystis is the major surface glycoprotein (Msg), which is encoded by a multi-copy gene family. Variation in the expressed Msg is thought to help this organism evade the host immune ...

[]

0

[ "PFAM" ]

[ "PF12373" ]

[ "Msg2_C" ]

[ 295 ]

1

[]

0

[]

0

[ "PUB00053333" ]

[ "18627244" ]

[ "Variation in the major surface glycoprotein genes in Pneumocystis jirovecii." ]

[ 2008 ]

1

[]

0

null

[ "Pneumocystis" ]

[ 295 ]

1

[]

0

true

Domain

Major surface glycoprotein 2, C-terminal

Maj_surf_glycoprot_2_C

8

IPR021042

21,042

Herpesvirus UL139, cytomegalovirus

Herpes_UL139_cytomegalovirus

Family

544

false

This entry represents eukaryotic and viral proteins of approximately 140 amino acids in length. The UL139 product shares sequence homology with human CD24, a signal transducer modulating B-cell activation responses, and the sequences in the G1c variant of UL139 contained a specific attachment site of prokaryotic membra...

[]

0

[ "PFAM" ]

[ "PF12507" ]

[ "HCMV_UL139" ]

[ 544 ]

1

[]

0

[]

0

[ "PUB00053300" ]

[ "16482559" ]

[ "Human cytomegalovirus (HCMV) UL139 open reading frame: Sequence variants are clustered into three major genotypes." ]

[ 2006 ]

1

[]

0

null

[ "Cytomegalovirus", "Spermatophyta" ]

[ 82, 462 ]

2

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 4, 4, 3 ]

3

true

Family

Herpesvirus UL139, cytomegalovirus

Herpes_UL139_cytomegalovirus

3

IPR021043

21,043

MKI67 FHA domain-interacting nucleolar phosphoprotein, FHA Ki67 binding

NIFK_FHA_Ki67-binding

Domain

893

false

This entry represents eukaryotic proteins that contain a domain of approximately 40 amino acids in length. These proteins are found in association with . There are two conserved sequence motifs: TPVCTP and LERRKS. This domain is found on the human nucleolar protein hNIFK. It binds to the fork-head-associated domain of ...

[]

0

[ "PFAM" ]

[ "PF12196" ]

[ "hNIFK_binding" ]

[ 893 ]

1

[]

0

[ "2aff", "8fkp", "8fkq", "8fkr", "8fks", "8fkt", "8fku", "8fkv", "8fkw", "8fkx", "8fky", "8fkz", "8fl2", "8fl3", "8fl6", "8fl7", "8fla", "8flb", "8fld", "8fle", "8ine", "8inf", "8ipx", "8ipy", "8ir3" ]

25

[ "PUB00039266" ]

[ "16244663" ]

[ "Sequential phosphorylation and multisite interactions characterize specific target recognition by the FHA domain of Ki67." ]

[ 2005 ]

1

[]

0

null

[ "Gnathostomata" ]

[ 893 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 3, 1, 4 ]

4

true

Domain

MKI67 FHA domain-interacting nucleolar phosphoprotein, FHA Ki67 binding

NIFK_FHA_Ki67-binding

8

IPR021044

21,044

Herpesvirus Glycoprotein B, antigenic domain, N-terminal

Glycoprot_B_antigenic_N

Domain

166

false

Herpesviruses are enveloped by a lipid bilayer that contains at least a dozen glycoproteins. The virion surface glycoproteins mediate recognition of susceptible cells and promote fusion of the viral envelope with the cell membrane, leading to virus entry. This domain is found in viruses, and is approximately 40 amino a...

[]

0

[ "PFAM" ]

[ "PF12154" ]

[ "HCMVantigenic_N" ]

[ 166 ]

1

[ "REACTOME", "REACTOME" ]

[ "R-HSA-9609690", "R-HSA-9610379" ]

[ "REACTOME:R-HSA-9609690", "REACTOME:R-HSA-9610379" ]

2

[ "7kdd", "7kdp", "7yrn", "8vym", "8vyn" ]

5

[ "PUB00053321" ]

[ "7979986" ]

[ "Sequence variation of the amino-terminal antigenic domains of glycoprotein B of human cytomegalovirus strains isolated from Chinese patients." ]

[ 1994 ]

1

[]

0

null

[ "Human cytomegalovirus" ]

[ 166 ]

1

[]

0

true

Domain

Herpesvirus Glycoprotein B, antigenic domain, N-terminal

Glycoprot_B_antigenic_N

9

IPR021046

21,046

Cold-shock protein, DEAD box A, C-terminal

Cold-shock_DEAD_Abox_C

Domain

1,080

false

This domain is found at the C terminus of the DeaD helicase, which are involved in various cellular processes such as transcription, translation and DNA recombination [ ]. This region contains several repeats which contain an ERRE sequence motif.

[ "GO:0016817" ]

[ "hydrolase activity, acting on acid anhydrides" ]

[ "molecular_function" ]

1

[ "PFAM" ]

[ "PF12343" ]

[ "DeaD_C" ]

[ 1080 ]

1

[ "EC" ]

[ "3.6.4.13" ]

[ "EC:3.6.4.13" ]

1

[]

0

[ "PUB00053301" ]

[ "8552679" ]

[ "Cold shock induces a major ribosomal-associated protein that unwinds double-stranded RNA in Escherichia coli." ]

[ 1996 ]

1

[]

0

null

[ "Bilateria", "Enterobacterales", "human gut metagenome" ]

[ 8, 1071, 1 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Domain

Cold-shock protein, DEAD box A, C-terminal

Cold-shock_DEAD_Abox_C

8

IPR021047

21,047

Mannosyltransferase 1, CMT1

Mannosyltransferase_CMT1

Family

4,881

false

The capsule of pathogenic fungi is a complex polysaccharide whose formation is determined by a number of enzymes including, most importantly, alpha-1,3-mannosyltransferase 1 [ , ]. It is responsible for addition of mannose residues in an alpha-1,3 linkage to a polymannosly precursor.

[]

0

[ "PFAM", "PANTHER" ]

[ "PF11735", "PTHR34144" ]

[ "CAP59_mtransfer", "" ]

[ 4868, 4704 ]

2

[]

0

[]

0

[ "PUB00053302", "PUB00053303" ]

[ "14504286", "16696646" ]

[ "An alpha-1,3-mannosyltransferase of Cryptococcus neoformans.", "Glycosyltransferases and their products: cryptococcal variations on fungal themes." ]

[ 2003, 2006 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "Halorubrum ezzemoulense", "Viruses", "viral metagenome" ]

[ 24, 4845, 1, 6, 5 ]

5

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)" ]

[ 2 ]

1

true

Family

Mannosyltransferase 1, CMT1

Mannosyltransferase_CMT1

5

IPR021048

21,048

Intracellular growth locus C protein

Intracellular_growth_locus_C

Family

42

false

IglC protein is involved in the escape of Francisella tularensis live vaccine strain [ ]. It has been shown that the expression of IglC is essential for F. tularensis to induce macrophage apoptosis [ ]. IglC adopts a β-sandwich conformation that has no similarity to any known protein structure [ ].

[]

0

[ "PFAM" ]

[ "PF11550" ]

[ "IglC" ]

[ 42 ]

1

[]

0

[ "2qwu" ]

1

[ "PUB00053304", "PUB00053305", "PUB00053306" ]

[ "18474647", "15519043", "17905833" ]

[ "MglA and Igl proteins contribute to the modulation of Francisella tularensis live vaccine strain-containing phagosomes in murine macrophages.", "Expression of IglC is necessary for intracellular growth and induction of apoptosis in murine macrophages by Francisella tularensis.", "New protein fold revealed by a...

[ 2008, 2004, 2007 ]

3

[]

0

null

[ "Pseudomonadota" ]

[ 42 ]

1

[]

0

true

Family

Intracellular growth locus C protein

Intracellular_growth_locus_C

4

IPR021049

21,049

Bacteriophage T4, Gp40, head assembly

Phage_T4_Gp40

Family

328

false

This head assembly protein is also refereed to as gene product 40 (Gp40). A specific gp20-gp40 membrane insertion structure constitutes the T4 prohead assembly initiation complex [ ].

[]

0

[ "PFAM" ]

[ "PF11113" ]

[ "Phage_head_chap" ]

[ 328 ]

1

[]

0

[]

0

[ "PUB00053307" ]

[ "2685327" ]

[ "Membrane-associated assembly of a phage T4 DNA entrance vertex structure studied with expression vectors." ]

[ 1989 ]

1

[]

0

null

[ "Flagellimonas marina", "Viruses" ]

[ 1, 327 ]

2

[]

0

true

Family

Bacteriophage T4, Gp40, head assembly

Phage_T4_Gp40

5

IPR021052

21,052

Holliday junction recognition protein, HJURP, central domain

HJURP_central_dom

Domain

273

false

This entry represents a central, conserved region found in Holliday junction recognition protein from humans (HJURP) and similar proteins from vertebrates. This domain is not present in Holliday junction recognition proteins from fungi. However, both the N-terminal domain and a repeated domain that appears further down...

[]

0

[ "PFAM" ]

[ "PF12346" ]

[ "HJURP_mid" ]

[ 273 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-606279", "R-HSA-69273", "R-MMU-606279", "R-MMU-69273" ]

[ "REACTOME:R-HSA-606279", "REACTOME:R-HSA-69273", "REACTOME:R-MMU-606279", "REACTOME:R-MMU-69273" ]

4

[]

0

[ "PUB00053308", "PUB00053309", "PUB00099842", "PUB00099843", "PUB00099844", "PUB00099845" ]

[ "19410544", "19410545", "30111352", "28840237", "33207191", "21412236" ]

[ "Centromere-specific assembly of CENP-a nucleosomes is mediated by HJURP.", "HJURP is a cell-cycle-dependent maintenance and deposition factor of CENP-A at centromeres.", "HJURP promotes hepatocellular carcinoma proliferation by destabilizing p21 via the MAPK/ERK1/2 and AKT/GSK3β signaling pathways.", "Orches...

[ 2009, 2009, 2018, 2017, 2020, 2011 ]

6

[]

0

null

[ "Eutheria" ]

[ 273 ]

1

[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 3, 5, 1 ]

3

true

Domain

Holliday junction recognition protein, HJURP, central domain

HJURP_central_dom

6

IPR021053

21,053

Dispersed gene family protein 1, C-terminal

Dispersed_gene_fam_prot1_C

Domain

899

false

Dispersed gene family protein 1 (DGF-1) of Trypanosoma cruzi is one of the most abundant proteins in T. cruzi genome [ , ]. It seems to have a preferential expression in amastigotes (intracellular replicative forms that develop in the mammalian host) [ ]. The function of this protein is not yet clear, however, it is li...

[]

0

[ "PFAM" ]

[ "PF11040" ]

[ "DGF-1_C" ]

[ 899 ]

1

[]

0

[]

0

[ "PUB00054242", "PUB00153905", "PUB00153906" ]

[ "18037385", "36839564", "19841080" ]

[ "Comparative codon and amino acid composition analysis of Tritryps-conspicuous features of Leishmania major.", "The Elusive <i>Trypanosoma cruzi</i> Disperse Gene Protein Family (DGF-1).", "Localization and developmental regulation of a dispersed gene family 1 protein in Trypanosoma cruzi." ]

[ 2007, 2023, 2010 ]

3

[]

0

null

[ "Metakinetoplastina" ]

[ 899 ]

1

[]

0

true

Domain

Dispersed gene family protein 1, C-terminal

Dispersed_gene_fam_prot1_C

8

IPR021055

21,055

Type-IV b secretion system, inner-membrane complex component

T4BSS_IcmL/DotI

Family

1,341

false

This is a family of DotI/IcmL proteins of type IVb secretion systems, that reside in the inner-membrane. It carries a single transmembrane helix in the N-terminal conserved region, has an extra-periplasmic domain, and is conserved in all T4BSSs including I-type conjugation systems (TraM). DotI/IcmL (and DotJ) may form ...

[]

0

[ "PFAM", "CDD" ]

[ "PF11393", "cd16385" ]

[ "T4BSS_DotI_IcmL", "IcmL" ]

[ 1340, 1258 ]

2

[]

0

[ "3wz3", "3wz4", "3wz5", "5cnl" ]

4

[ "PUB00075640" ]

[ "21743810" ]

[ "Type IVB Secretion Systems of Legionella and Other Gram-Negative Bacteria." ]

[ 2011 ]

1

[]

0

null

[ "Bacteria", "Opisthokonta", "Plasmid R64", "ecological metagenomes" ]

[ 1330, 2, 1, 8 ]

4

[]

0

true

Family

Type-IV b secretion system, inner-membrane complex component

T4BSS_IcmL/DotI

3

IPR021056

21,056

Mitochondrial import inner membrane translocase subunit Tim54

Mt_import_IM_translocase_Tim54

Family

1,731

false

Mitochondrial function depends on the import of hundreds of different proteins synthesised in the cytosol. Protein import is a multi-step pathway which includes the binding of precursor proteins to surface receptors, translocation of the precursor across one or both mitochondrial membranes, and folding and assembly of ...

[]

0

[ "PFAM" ]

[ "PF11711" ]

[ "Tim54" ]

[ 1731 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-SCE-1483206", "R-SCE-1660661", "R-SPO-1483206", "R-SPO-1660661" ]

[ "REACTOME:R-SCE-1483206", "REACTOME:R-SCE-1660661", "REACTOME:R-SPO-1483206", "REACTOME:R-SPO-1660661" ]

4

[ "6lo8" ]

1

[ "PUB00053314" ]

[ "9412462" ]

[ "The Tim54p-Tim22p complex mediates insertion of proteins into the mitochondrial inner membrane." ]

[ 1997 ]

1

[]

0

null

[ "Eukaryota" ]

[ 1731 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 1, 1 ]

3

true

Family

Mitochondrial import inner membrane translocase subunit Tim54

Mt_import_IM_translocase_Tim54

9

IPR021057

21,057

Trypanosome invariant surface glycoprotein

Trypano_invariant_glycop

Family

256

false

This family is found in Trypanosome species, and appears to be one of two invariant surface glycoproteins, ISG65 and ISG75, that are found in the mammalian stage of the parasitic protozoan. The sequence suggests the two families are polypeptides with N-terminal signal sequences, hydrophilic extracellular domains, singl...

[]

0

[ "PFAM" ]

[ "PF11727" ]

[ "ISG65-75" ]

[ 256 ]

1

[]

0

[ "7pi6", "7zgj", "7zgk", "8ovb", "8rd2" ]

5

[ "PUB00053315", "PUB00053316" ]

[ "1587856", "18538880" ]

[ "Molecular characterization of two invariant surface glycoproteins specific for the bloodstream stage of Trypanosoma brucei.", "Heterologous expression, purification and characterisation of the extracellular domain of trypanosome invariant surface glycoprotein ISG75." ]

[ 1992, 2008 ]

2

[]

0

null

[ "Bacillus cereus VD048", "Eukaryota" ]

[ 1, 255 ]

2

[]

0

true

Family

Trypanosome invariant surface glycoprotein

Trypano_invariant_glycop

2

IPR021058

21,058

Porin OmpL1

Porin_OmpL1

Family

270

false

OmpL1 is a member of the outer membrane (OM) proteins in the mammalian pathogen Leptospira. Specifically, it is a porin [ , , ].

[ "GO:0015288", "GO:0055085", "GO:0005886" ]

[ "porin activity", "transmembrane transport", "plasma membrane" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PFAM" ]

[ "PF11389" ]

[ "Porin_OmpL1" ]

[ 270 ]

1

[]

0

[]

0

[ "PUB00053317", "PUB00060967", "PUB00060968" ]

[ "12183539", "7622245", "8320237" ]

[ "Characterization of the leptospiral outer membrane and description of three novel leptospiral membrane proteins.", "The rare outer membrane protein, OmpL1, of pathogenic Leptospira species is a heat-modifiable porin.", "Molecular cloning and sequence analysis of the gene encoding OmpL1, a transmembrane outer m...

[ 2002, 1995, 1993 ]

3

[]

0

null

[ "Pseudomonadati" ]

[ 270 ]

1

[]

0

true

Family

Porin OmpL1

Porin_OmpL1

8

IPR021059

21,059

DnaJ-related protein, N-terminal

DnaJ-related_N

Domain

1,148

false

This domain family is approximately 130 amino acids in length and contains a conserved YYLD sequence motif. The proteins have a C-terminal DNA-J domain and most of the sequences are annotated as DNA-J related proteins, other annotations include: DnaJ-class molecular chaperon and formate dehydrogenase; but there is curr...

[]

0

[ "PFAM" ]

[ "PF12339" ]

[ "DNAJ_related" ]

[ 1148 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "unclassified sequences" ]

[ 1128, 20 ]

2

[]

0

true

Domain

DnaJ-related protein, N-terminal

DnaJ-related_N

9

IPR021061

21,061

Mitochondrial division protein 1

Mt_division_protein_1

Family

22

false

This entry represents mitochondrial division protein 1 (Mdv1), which is a component of the mitochondrial fission machinery in Saccharomyces cerevisiae. The protein is also involved in peroxisome proliferation [ ]. Mdv1 along with Fis1 is also involved in controlling Dnm-1 dependent devision, a GTPase involved in the me...

[]

0

[ "PFAM" ]

[ "PF11542" ]

[ "Mdv1" ]

[ 22 ]

1

[]

0

[ "2pqn", "3uux" ]

2

[ "PUB00038450", "PUB00053318", "PUB00053319", "PUB00053320" ]

[ "15809300", "18513378", "16272155", "16009724" ]

[ "Novel structure of the N terminus in yeast Fis1 correlates with a specialized function in mitochondrial fission.", "Peroxisome fission in Hansenula polymorpha requires Mdv1 and Fis1, two proteins also involved in mitochondrial fission.", "Mdv1 interacts with assembled dnm1 to promote mitochondrial division.", ...

[ 2005, 2008, 2006, 2005 ]

4

[]

0

null

[ "Saccharomycetaceae" ]

[ 22 ]

1

[ "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)" ]

[ 1 ]

1

true

Family

Mitochondrial division protein 1

Mt_division_protein_1

4

IPR021062

21,062

Putative aromatic acid exporter, C-terminal

ArAE_1_C

Domain

2,795

false

This region is a presumed intracellular domain found in a set of bacterial presumed transporter proteins. The region is about 160 amino acids in length.

[]

0

[ "PFAM" ]

[ "PF11728" ]

[ "ArAE_1_C" ]

[ 2795 ]

1

[]

0

[ "3kmi" ]

1

[]

0

[]

0

null

[ "Bacteria", "Methanolapillus millepedarum", "Opisthokonta", "metagenomes" ]

[ 2781, 1, 10, 3 ]

4

[]

0

true

Domain

Putative aromatic acid exporter, C-terminal

ArAE_1_C

9

IPR021063

21,063

NF-kappa-B essential modulator NEMO, N-terminal

NEMO_N

Domain

1,977

false

This entry represents a conserved domain found at the N-terminal of NF-kappa-B essential modulator (NEMO) and optineurin proteins. NEMO is a regulatory protein which is part of the IKK complex along with the catalytic IKKalpha and beta kinases. The IKK complex phosphorylates IkappaB targeting it for degradation which r...

[]

0

[ "PFAM" ]

[ "PF11577" ]

[ "NEMO" ]

[ 1977 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-1169091", "R-BTA-168638", "R-BTA-1810476", "R-BTA-202424", "R-BTA-2871837", "R-BTA-445989", "R-BTA-450302", "R-BTA-450321", "R-BTA-4755510", "R-BTA-5357905", "R-BTA-5357956", "R-BTA-5607764", "R-BTA-5684264", "R-BTA-5689880", "R-BTA-5689896", "R-BTA-9020702", "R-BTA-933542", ...

[ "REACTOME:R-BTA-1169091", "REACTOME:R-BTA-168638", "REACTOME:R-BTA-1810476", "REACTOME:R-BTA-202424", "REACTOME:R-BTA-2871837", "REACTOME:R-BTA-445989", "REACTOME:R-BTA-450302", "REACTOME:R-BTA-450321", "REACTOME:R-BTA-4755510", "REACTOME:R-BTA-5357905", "REACTOME:R-BTA-5357956", "REACTOME:R-B...

156

[ "3brt", "3brv", "5eoa", "5eof", "6mi3", "6mi4", "8u7c" ]

7

[ "PUB00050744" ]

[ "18462684" ]

[ "Structure of a NEMO/IKK-associating domain reveals architecture of the interaction site." ]

[ 2008 ]

1

[]

0

null

[ "Bacteria", "Eumetazoa" ]

[ 3, 1974 ]

2

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 4, 20, 11, 11 ]

4

true

Domain

NF-kappa-B essential modulator NEMO, N-terminal

NEMO_N

4

IPR021064

21,064

Estrogen receptor beta-like, N-terminal

ER-beta-like_N

Domain

1,903

false

This entry represents the N-terminal domain of Estrogen receptor beta (ER-beta) and similar proteins from eukaryotes. This domain has approximately 110 amino acids in length and is usually found in association with , . There is a conserved IPS sequence motif and there are two completely conserved residues (Y and W) tha...

[]

0

[ "PFAM" ]

[ "PF12497" ]

[ "ERbeta_N" ]

[ 1903 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-1257604", "R-BTA-383280", "R-BTA-6811558", "R-BTA-8939211", "R-BTA-9009391", "R-HSA-1257604", "R-HSA-2219530", "R-HSA-383280", "R-HSA-6811558", "R-HSA-8939211", "R-HSA-9009391", "R-MMU-1257604", "R-MMU-383280", "R-MMU-6811558", "R-MMU-8939211", "R-MMU-9009391", "R-RNO-1257604"...

[ "REACTOME:R-BTA-1257604", "REACTOME:R-BTA-383280", "REACTOME:R-BTA-6811558", "REACTOME:R-BTA-8939211", "REACTOME:R-BTA-9009391", "REACTOME:R-HSA-1257604", "REACTOME:R-HSA-2219530", "REACTOME:R-HSA-383280", "REACTOME:R-HSA-6811558", "REACTOME:R-HSA-8939211", "REACTOME:R-HSA-9009391", "REACTOME:...

21

[]

0

[ "PUB00053322", "PUB00099833", "PUB00099835" ]

[ "9325313", "20074560", "30113650" ]

[ "Human estrogen receptor beta binds DNA in a manner similar to and dimerizes with estrogen receptor alpha.", "Repression of estrogen receptor beta function by putative tumor suppressor DBC1.", "Early-Onset Complete Ovarian Failure and Lack of Puberty in a Woman With Mutated Estrogen Receptor β (ESR2)." ]

[ 1997, 2010, 2018 ]

3

[]

0

null

[ "Gnathostomata" ]

[ 1903 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 11, 14, 4, 11 ]

4

true

Domain

Estrogen receptor beta-like, N-terminal

ER-beta-like_N

8

IPR021065

21,065

Fertility inhibition protein FinO, N-terminal

Fertility_inhibition_FinO_N

Domain

602

false

This entry represents the N-terminal of the Fertility inhibition protein FinO, found in bacteria, and is typically between 62 and 102 amino acids in length.

[]

0

[ "PFAM" ]

[ "PF12602" ]

[ "FinO_N" ]

[ 602 ]

1

[]

0

[ "1dvo" ]

1

[ "PUB00053323" ]

[ "1374147" ]

[ "Differential levels of fertility inhibition among F-like plasmids are related to the cellular concentration of finO mRNA." ]

[ 1992 ]

1

[]

0

null

[ "Bacteria", "Trichuris trichiura", "human gut metagenome" ]

[ 600, 1, 1 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Domain

Fertility inhibition protein FinO, N-terminal

Fertility_inhibition_FinO_N

5

IPR021066

21,066

Fungal protease inhibitor-1

FPI1

Family

144

false

This entry represents fungal proteinase inhibitors found mainly in arthropodes, including fungal protease inhibitor-1 (FPI-1) from Antheraea mylitta (Tasar silkworm). FPI1 inhibits trypsin and chymotrypsin proteases from the fungi Aspergillus oryzae and Rhizopus oryzae. However, they do not inhibit papain-like protease...

[ "GO:0030414", "GO:0010466" ]

[ "peptidase inhibitor activity", "negative regulation of peptidase activity" ]

[ "molecular_function", "biological_process" ]

2

[ "PFAM" ]

[ "PF12190" ]

[ "amfpi-1" ]

[ 144 ]

1

[]

0

[ "3bt4" ]

1

[ "PUB00053324", "PUB00099800" ]

[ "14505696", "19263521" ]

[ "Protein purification, cDNA cloning and characterization of a protease inhibitor from the Indian tasar silkworm, Antheraea mylitta.", "Crystal structure of a fungal protease inhibitor from Antheraea mylitta." ]

[ 2003, 2009 ]

2

[]

0

null

[ "Bacteria", "Protostomia" ]

[ 3, 141 ]

2

[]

0

true

Family

Fungal protease inhibitor-1

FPI1

5

IPR021067

21,067

Glycosyltransferase, GlcNAc

Glycosyltransferase

Family

2,029

false

GlcNAc is an enzyme that carries out the first glycosylation step of hydroxylated Skp1; it is found in the cytoplasm and results in a pentasaccharide-linked 'HyPro-143[ , ].

[]

0

[ "PFAM", "PANTHER" ]

[ "PF11397", "PTHR34496" ]

[ "GlcNAc", "" ]

[ 1995, 1971 ]

2

[]

0

[]

0

[ "PUB00053325", "PUB00053326" ]

[ "12244115", "12097910" ]

[ "Molecular cloning and expression of a UDP-N-acetylglucosamine (GlcNAc):hydroxyproline polypeptide GlcNAc-transferase that modifies Skp1 in the cytoplasm of dictyostelium.", "Sequence and analysis of chromosome 2 of Dictyostelium discoideum." ]

[ 2002, 2002 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "Viruses", "metagenomes" ]

[ 393, 1587, 24, 25 ]

4

[]

0

true

Family

Glycosyltransferase, GlcNAc

Glycosyltransferase

7

IPR021068

21,068

HTH DNA binding domain

HTH_DNA-bd

Domain

1,317

false

This entry represents the C-terminal helix-turn-helix DNA binding domain of a group of bacterial uncharacterised proteins, including Uncharacterized protein y4cF from Sinorhizobium fredii.

[]

0

[ "PFAM" ]

[ "PF11972" ]

[ "HTH_13" ]

[ 1317 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Methanomicrobia", "ecological metagenomes" ]

[ 1296, 4, 10, 7 ]

4

[]

0

true

Domain

HTH DNA binding domain

HTH_DNA-bd

9

IPR021069

21,069

ImpA, C-terminal

ImpA_C

Domain

1,449

false

This entry represents a conserved region located towards the C-terminal end of ImpA and related proteins. ImpA is an inner membrane protein, which has been suggested to be involved with proteins that are exported and associated with colony variations in Actinobacillus actinomycetemcomitans [ ]. Note that many members a...

[]

0

[ "PFAM" ]

[ "PF12486" ]

[ "VasL" ]

[ 1449 ]

1

[]

0

[]

0

[ "PUB00012845" ]

[ "11083768" ]

[ "impA, a gene coding for an inner membrane protein, influences colonial morphology of Actinobacillus actinomycetemcomitans." ]

[ 2000 ]

1

[]

0

null

[ "Bacteria", "Opisthokonta", "human gut metagenome" ]

[ 1446, 2, 1 ]

3

[]

0

true

Domain

ImpA, C-terminal

ImpA_C

3

IPR021070

21,070

Killing trait, RebB

Killing_trait_RebB

Family

2,420

false

R-bodies are highly insoluble protein ribbons which coil into cylindrical structures in the cell and the genes for their synthesis and assembly are encoded on a plasmid. One of these three proteins is RebB, which this entry represents. RebB is one of three proteins necessary for the production of R- bodies, refractile ...

[]

0

[ "PFAM" ]

[ "PF11747" ]

[ "RebB" ]

[ 2420 ]

1

[]

0

[]

0

[ "PUB00053327", "PUB00053328" ]

[ "8206833", "15785846" ]

[ "Characterization of genetic determinants for R body synthesis and assembly in Caedibacter taeniospiralis 47 and 116.", "Sequence, transcription activity, and evolutionary origin of the R-body coding plasmid pKAP298 from the intracellular parasitic bacterium Caedibacter taeniospiralis." ]

[ 1994, 2005 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "ecological metagenomes" ]

[ 2407, 10, 3 ]

3

[]

0

true

Family

Killing trait, RebB

Killing_trait_RebB

2

IPR021071

21,071

Low molecular weight S layer protein, N-terminal

Low_molc_weight_S-layer_N

Domain

171

false

Clostridial species have a layer of surface proteins surrounding their membrane. This layer is comprised of a high molecular weight protein and a low molecular weight protein. It is a structural domain. This domain is the N-terminal domain of the low molecular weight protein. There is a conserved LGDG sequence motif [ ...

[]

0

[ "PFAM" ]

[ "PF12211" ]

[ "LMWSLP_N" ]

[ 171 ]

1

[]

0

[ "3cvz", "7acv", "7acx", "7acy", "7acz", "7qgq", "8bby", "9f8f" ]

8

[ "PUB00051147" ]

[ "19183279" ]

[ "Structural insights into the molecular organization of the S-layer from Clostridium difficile." ]

[ 2009 ]

1

[]

0

null

[ "Clostridioides difficile" ]

[ 171 ]

1

[]

0

true

Domain

Low molecular weight S layer protein, N-terminal

Low_molc_weight_S-layer_N

9

IPR021072

21,072

Melanoma associated antigen, N-terminal

MAGE_N

Domain

3,002

false

This domain is found N-terminal in various melanoma associated antigens from eukaryotes, and is typically between 82 and 96 amino acids in length. These are tumour rejection antigens which are expressed on HLA-A1 of tumour cells and they are recognised by cytotoxic T lymphocytes (CTLs) [ ].

[]

0

[ "PFAM", "SMART" ]

[ "PF12440", "SM01392" ]

[ "MAGE_N", "MAGE_N" ]

[ 2752, 2782 ]

2

[]

0

[]

0

[ "PUB00053329" ]

[ "7642112" ]

[ "Sequence analysis of the MAGE gene family encoding human tumor-rejection antigens." ]

[ 1995 ]

1

[]

0

null

[ "Eutheria" ]

[ 3002 ]

1

[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 67, 13, 26 ]

3

true

Domain

Melanoma associated antigen, N-terminal

MAGE_N

2

IPR021073

21,073

Murid betaherpesvirus 1, M157

MuHV-1_M157

Family

105

false

This entry represents the M157 glycoprotein, a divergent form of MHC class I-like proteins which is the protein product of Murid betaherpesvirus 1. This protein is unique in its ability to engage both activating (Ly49H) and inhibitory (Ly49I) natural killer cell receptors. M157 is involved in intra- and intermolecular ...

[]

0

[ "PFAM" ]

[ "PF11624" ]

[ "M157" ]

[ 105 ]

1

[]

0

[ "2nyk", "4jo8" ]

2

[ "PUB00048408" ]

[ "17537914" ]

[ "Structural elucidation of the m157 mouse cytomegalovirus ligand for Ly49 natural killer cell receptors." ]

[ 2007 ]

1

[]

0

null

[ "Muromegalovirus" ]

[ 105 ]

1

[]

0

true

Family

Murid betaherpesvirus 1, M157

MuHV-1_M157

9

IPR021074

21,074

Formate dehydrogenase, delta subunit

Formate_DH_dsu

Family

3,068

false

FdsD is the delta subunit of the enzyme formate dehydrogenase. This subunit may play a role in maintaining the quaternary structure by means of electrostatic interactions with the other subunits [ ]. The delta subunit is not involved in the active centre of the enzyme [ ].

[]

0

[ "PFAM" ]

[ "PF11390" ]

[ "FdsD" ]

[ 3068 ]

1

[]

0

[ "6tg9", "6tga", "9ktl", "9ktr" ]

4

[ "PUB00053330" ]

[ "9756865" ]

[ "Structural analysis of the fds operon encoding the NAD+-linked formate dehydrogenase of Ralstonia eutropha." ]

[ 1998 ]

1

[]

0

null

[ "Bacteria", "unclassified sequences" ]

[ 2988, 80 ]

2

[]

0

true

Family

Formate dehydrogenase, delta subunit

Formate_DH_dsu

2

IPR021075

21,075

Bocavirus non-capsid protein, NP1

Bocavirus_NP1

Family

277

false

This entry represents the bocavirus non-capsid protein NP1 [ ].

[]

0

[ "PFAM" ]

[ "PF11733" ]

[ "NP1-WLL" ]

[ 277 ]

1

[]

0

[]

0

[ "PUB00053331" ]

[ "18217564" ]

[ "Human bocavirus infection in children with gastroenteritis, Brazil." ]

[ 2007 ]

1

[]

0

null

[ "Brachionus plicatilis", "Parvoviridae", "Sedimentisphaera salicampi" ]

[ 1, 275, 1 ]

3

[]

0

true

Family

Bocavirus non-capsid protein, NP1

Bocavirus_NP1

8

IPR021076

21,076

Parvovirus non-structural protein 1, N-terminal

Parvovirus_NS1_N

Domain

1,359

false

This entry represents a domain of the parvovirus Initiator protein 1 (NS1, also known as non-structural protein 1). It is found immediately N-terminal to the helicase domain and binds to the origin of replication [ ]. Parvoviral NS1 regulates host gene expression through histone acetylation [ ]. Parvoviruses are some o...

[]

0

[ "PFAM" ]

[ "PF12433" ]

[ "PV_NSP1" ]

[ 1359 ]

1

[ "EC", "EC" ]

[ "3.1.21.-", "3.6.4.12" ]

[ "EC:3.1.21.-", "EC:3.6.4.12" ]

2

[ "3wrn", "3wro", "3wrq", "3wrr", "3wrs", "4pp4", "4r94" ]

7

[ "PUB00053332", "PUB00054921", "PUB00096850", "PUB00096898" ]

[ "15994782", "20097398", "9813208", "12050365" ]

[ "Parvovirus nonstructural proteins induce an epigenetic modification through histone acetylation in host genes and revert tumor malignancy to benignancy.", "Determination and analysis of the full-length chicken parvovirus genome.", "Amino acids 16-275 of minute virus of mice NS1 include a domain that specifical...

[ 2005, 2010, 1998, 2002 ]

4

[]

0

null

[ "Parvoviridae" ]

[ 1359 ]

1

[]

0

true

Domain

Parvovirus non-structural protein 1, N-terminal

Parvovirus_NS1_N

7

IPR021077

21,077

Bacteriophage phi-Lf, Orf112

Phage_phi-Lf_Orf112

Family

371

false

This entry represents a phage protein found in bacteria and viruses, they are typically between 112 and 194 amino acids in length. Note that many members are hypothetical proteins.

[]

0

[ "PFAM" ]

[ "PF12375" ]

[ "DUF3653" ]

[ 371 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Viruses", "mine drainage metagenome" ]

[ 352, 16, 3 ]

3

[]

0

true

Family

Bacteriophage phi-Lf, Orf112

Phage_phi-Lf_Orf112

8

IPR021078

21,078

Membrane-integrating protein Mistic

Membrane-integrating_Mistic

Family

185

false

Mistic is an integral membrane protein that folds autonomously into the membrane [ ]. It is conserved in the Bacilli bacteria. The protein forms a helical bundle with a polar lipid-facing surface. Mistic can be used for high-level production of other membrane proteins in their native conformations [ ].

[]

0

[ "PFAM" ]

[ "PF11458" ]

[ "Mistic" ]

[ 185 ]

1

[]

0

[ "1ygm" ]

1

[ "PUB00032647" ]

[ "15731457" ]

[ "NMR structure of Mistic, a membrane-integrating protein for membrane protein expression." ]

[ 2005 ]

1

[]

0

null

[ "Bacteria" ]

[ 185 ]

1

[]

0

true

Family

Membrane-integrating protein Mistic

Membrane-integrating_Mistic

9

IPR021079

21,079

Methanol-cobalamin methyltransferase, B subunit

MeOH-cob_MeTrfase_bsu

Family

291

false

This entry represents a family of methanol-cobalamin methyltransferase B subunit (MtaB) proteins found in archaea and some species for Firmicutes. Proteins in this family are approximately 460 amino acids in length. MtaB folds as a TIM barrel and contains a novel zinc-binding motif. Zinc(II) lies at the bottom of a fun...

[]

0

[ "NCBIFAM", "PFAM" ]

[ "NF040651", "PF12176" ]

[ "MtaB_Meth", "MtaB" ]

[ 185, 291 ]

2

[]

0

[ "2i2x" ]

1

[ "PUB00047666", "PUB00105876", "PUB00105877", "PUB00105878" ]

[ "17142327", "9057830", "9363780", "9654068" ]

[ "Insight into the mechanism of biological methanol activation based on the crystal structure of the methanol-cobalamin methyltransferase complex.", "Methanol:coenzyme M methyltransferase from Methanosarcina barkeri. Purification, properties and encoding genes of the corrinoid protein MT1.", "Methanol:coenzyme M...

[ 2006, 1997, 1997, 1998 ]

4

[]

0

null

[ "Archaea", "Bacteria", "unclassified sequences" ]

[ 197, 74, 20 ]

3

[]

0

true

Family

Methanol-cobalamin methyltransferase, B subunit

MeOH-cob_MeTrfase_bsu

7

IPR021080

21,080

Minor capsid protein

Minor_capsid_protein

Family

693

false

This entry represents a family of minor capsid proteins found in a number of bacteriophages including Bacteriophage A118. The function of these proteins is not known.

[]

0

[ "PFAM" ]

[ "PF11114" ]

[ "Minor_capsid_2" ]

[ 693 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Viruses", "bioreactor metagenome" ]

[ 550, 2, 140, 1 ]

4

[]

0

true

Family

Minor capsid protein

Minor_capsid_protein

9

IPR021081

21,081

Nepovirus subgroup A, RNA2 polyprotein, Protein 2A

Nepovirus_subgr_A_2A

Domain

266

false

Nepoviruses are plant viruses that, together with comoviruses and picornaviruses, are classified in the picornavirus superfamily of plus strand single-stranded RNA viruses. Its genome consist of two single-stranded RNAs, both required for infection [ ]. RNA2 from the subgroup A of these viruses encode the polyprotein P...

[]

0

[ "PFAM" ]

[ "PF12312" ]

[ "NeA_P2" ]

[ 266 ]

1

[]

0

[]

0

[ "PUB00099813", "PUB00099814" ]

[ "10544127", "34370094" ]

[ "Protein 2A of grapevine fanleaf nepovirus is implicated in RNA2 replication and colocalizes to the replication site.", "Metagenomic analysis of nepoviruses: diversity, evolution and identification of a genome region in members of subgroup A that appears to be important for host range." ]

[ 1999, 2021 ]

2

[]

0

null

[ "Nepovirus" ]

[ 266 ]

1

[]

0

true

Domain

Nepovirus subgroup A, RNA2 polyprotein, Protein 2A

Nepovirus_subgr_A_2A

7

IPR021082

21,082

Protein GAPT

Protein_GAPT

Family

226

false

Protein GAPT (also known as Growth-factor Receptor-Bound protein 2 (GRB2)-binding adaptor protein, transmembrane) belongs to a class of transmembrane (TM) adaptor proteins that couple antigen receptor engagement to downstream signalling cascades in lymphocytes [ ]. Expressed in B cells and myeloid cells, GAPT negativel...

[ "GO:0016020" ]

[ "membrane" ]

[ "cellular_component" ]

1

[ "PFAM", "PRINTS", "PANTHER" ]

[ "PF11770", "PR02077", "PTHR37350" ]

[ "GAPT", "PROTEINGAPT", "" ]

[ 226, 160, 162 ]

3

[]

0

[]

0

[ "PUB00053335" ]

[ "18559951" ]

[ "Identification of a new transmembrane adaptor protein that constitutively binds Grb2 in B cells." ]

[ 2008 ]

1

[]

0

null

[ "Cytomegalovirus macacinebeta3", "Eukaryota", "Lactobacillaceae" ]

[ 2, 217, 7 ]

3

[ "Homo sapiens", "Mus musculus", "Rattus norvegicus", "Zea mays" ]

[ 3, 1, 2, 2 ]

4

true

Family

Protein GAPT

Protein_GAPT

1

IPR021083

21,083

Nuclear abundant poly(A) RNA-binding protein Nab2, N-terminal

Nab2_N

Domain

99

false

Nab2 is a yeast heterogeneous nuclear ribonucleoprotein that modulates poly(A) tail length and mRNA. This is the N-terminal domain of the protein which mediates interactions with the C-terminal globular domain, Myosin-like protein 1 and the mRNA export factor, Gfd1 [ ]. The N-terminal domain of Nab2 shows a structure o...

[]

0

[ "PFAM" ]

[ "PF11517" ]

[ "Nab2" ]

[ 99 ]

1

[]

0

[ "2jps", "2v75", "3lcn" ]

3

[ "PUB00048028" ]

[ "18190927" ]

[ "Structure of the N-terminal Mlp1-binding domain of the Saccharomyces cerevisiae mRNA-binding protein, Nab2." ]

[ 2008 ]

1

[]

0

null

[ "Saccharomycotina" ]

[ 99 ]

1

[ "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)" ]

[ 1 ]

1

true

Domain

Nuclear abundant poly(A) RNA-binding protein Nab2, N-terminal

Nab2_N

3

IPR021084

21,084

Het-s prion-forming domain

Het-s_prion_dom

Domain

242

false

This entry represents the prion domain of Het-s. Het-s plays a role in heterokaryon incompatibility, which prevents different forms of parasitism [ ]. The C terminus of Het-s is unstructured in solution but, in vitro, amyloid fibrils from the prion-forming domain form a structure consisting of a left-handed β-solenoid ...

[]

0

[ "PFAM" ]

[ "PF11558" ]

[ "HET-s_218-289" ]

[ 242 ]

1

[]

0

[ "2kj3", "2lbu", "2mus", "2rnm" ]

4

[ "PUB00049442" ]

[ "18339938" ]

[ "Amyloid fibrils of the HET-s(218-289) prion form a beta solenoid with a triangular hydrophobic core." ]

[ 2008 ]

1

[]

0

null

[ "leotiomyceta" ]

[ 242 ]

1

[]

0

true

Domain

Het-s prion-forming domain

Het-s_prion_dom

1

IPR021085

21,085

AvrE-family Type-III effector protein

AvrE_T3Es

Family

514

false

This family is secreted by Gram-negative Gammaproteobacteria such as Pseudomonas syringae of tomato and Erwinia amylovora (Fire blight bacteria), amongst others. It is an essential pathogenicity factor of approximately 198kDa. Its injection into the host-plant is dependent upon the bacterial type III or Hrp secretion s...

[]

0

[ "PFAM" ]

[ "PF11725" ]

[ "AvrE_T3Es" ]

[ 514 ]

1

[]

0

[]

0

[ "PUB00053336", "PUB00053337", "PUB00091028", "PUB00091029" ]

[ "9555912", "17022173", "27191168", "23421848" ]

[ "Erwinia amylovora secretes DspE, a pathogenicity factor and functional AvrE homolog, through the Hrp (type III secretion) pathway.", "WtsE, an AvrE-family effector protein from Pantoea stewartii subsp. stewartii, causes disease-associated cell death in corn and requires a chaperone protein for stability.", "Di...

[ 1998, 2006, 2016, 2013 ]

4

[]

0

null

[ "Beauveria bassiana D1-5", "Pseudomonadota" ]

[ 1, 513 ]

2

[]

0

true

Family

AvrE-family Type-III effector protein

AvrE_T3Es

8

IPR021086

21,086

Accessory protein p12I

p12I

Family

408

false

This entry represents viral proteins of approximately 100 amino acids in length. p12I binds to the immature beta and gamma-c chains of the interleukin-2 receptor retarding their translocation to the plasma membrane. p12I forms dimers which bind to these chains [ ].

[]

0

[ "PFAM" ]

[ "PF12233" ]

[ "p12I" ]

[ 408 ]

1

[]

0

[]

0

[ "PUB00053338" ]

[ "10400740" ]

[ "A lysine-to-arginine change found in natural alleles of the human T-cell lymphotropic/leukemia virus type 1 p12(I) protein greatly influences its stability." ]

[ 1999 ]

1

[]

0

null

[ "Human T-cell leukemia virus type I" ]

[ 408 ]

1

[]

0

true

Family

Accessory protein p12I

p12I

6

IPR021087

21,087

Uncharacterised protein family PixA/AidA

Uncharacterised_PixA/AidA

Family

995

false

This entry represents bacterial proteins that are typically between 173 and 191 amino acids in length. PixA is thought to be specifically produced in Xenorhabdus nematophila. It is an inclusion body protein [ ]. This entry also matches AidA.

[]

0

[ "PFAM" ]

[ "PF12306" ]

[ "PixA" ]

[ 995 ]

1

[]

0

[ "4lzk", "4pib", "4q52" ]

3

[ "PUB00053339" ]

[ "16547059" ]

[ "Analysis of the PixA inclusion body protein of Xenorhabdus nematophila." ]

[ 2006 ]

1

[]

0

null

[ "Bacteria", "Eukaryota" ]

[ 976, 19 ]

2

[]

0

true

Family

Uncharacterised protein family PixA/AidA

Uncharacterised_PixA/AidA

6

IPR021089

21,089

Bacteriocin, lactococcin-G

Bacteriocin_lactococcin-G

Family

9

false

This entry represents Lactococcin-G subunit beta, which together with subunit alpha constitutes the two-peptide bacteriocin lactococcin G. This family of proteins represents the N-terminal domain which has an α-helical structure and is amphiphilic. Both peptides have a GxxxG motif which they use for interaction through...

[]

0

[ "PFAM" ]

[ "PF11632" ]

[ "LcnG-beta" ]

[ 9 ]

1

[]

0

[ "2jpk", "2jpm" ]

2

[ "PUB00048019", "PUB00053394" ]

[ "18187052", "1512201" ]

[ "Three-dimensional structure of the two peptides that constitute the two-peptide bacteriocin lactococcin G.", "A novel lactococcal bacteriocin whose activity depends on the complementary action of two peptides." ]

[ 2008, 1992 ]

2

[]

0

null

[ "Bacillota" ]

[ 9 ]

1

[]

0

true

Family

Bacteriocin, lactococcin-G

Bacteriocin_lactococcin-G

4

IPR021090

21,090

SLy proteins associated disordered region

SPIDER

Domain

4,067

false

This entry represents the SLy proteins associated disordered region (SPIDER), which is conserved in the SLy protein family. It has a disordered nature and ranges from 143 to 154 residues long. The region includes a conserved LGKK motif of unknown function as well as a nuclear localisation sequence [ , , , ]. In most me...

[]

0

[ "PFAM" ]

[ "PF12485" ]

[ "SPIDER" ]

[ 4067 ]

1

[]

0

[]

0

[ "PUB00053342", "PUB00086052", "PUB00125663", "PUB00127314", "PUB00151489", "PUB00151490" ]

[ "11470164", "21820526", "11594764", "16227612", "32147820", "37155029" ]

[ "Molecular cloning and characterization of a novel SH3 protein (SLY) preferentially expressed in lymphoid cells.", "The candidate tumor suppressor SASH1 interacts with the actin cytoskeleton and stimulates cell-matrix adhesion.", "Identification of Nash1, a novel protein containing a nuclear localization signal...

[ 2001, 2011, 2001, 2005, 2020, 2023 ]

6

[]

0

null

[ "Vertebrata" ]

[ 4067 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 46, 10, 7, 13 ]

4

true

Domain

SLy proteins associated disordered region

SPIDER

1

IPR021091

21,091

Mercury ion transport, MerF

Mercury_ion_transport_MerF

Family

575

false

This entry represents Mercury ion transport protein MerF. This protein, the smallest encoded by the mer operon in bacteria, plays a role in the resistance to environmental mercury toxicity by importing Hg2+ and reducing it to volatile Hg(0) [ ]. It has also been related to the trasport of cadmium [ ]. MerF has a core h...

[ "GO:0016020" ]

[ "membrane" ]

[ "cellular_component" ]

1

[ "PFAM" ]

[ "PF11431" ]

[ "Transport_MerF" ]

[ 575 ]

1

[]

0

[ "1waz", "2h3o", "2lj2", "2m67", "2moz" ]

5

[ "PUB00032227", "PUB00099808", "PUB00099809" ]

[ "15794657", "3119092", "31721253" ]

[ "NMR structure determination of a membrane protein with two transmembrane helices in micelles: MerF of the bacterial mercury detoxification system.", "Accounting for cross boundary flows.", "A Minimal Membrane Metal Transport System: Dynamics and Energetics of mer Proteins." ]

[ 2005, 1987, 2020 ]

3

[]

0

null

[ "Bacteria", "Plasmid pMCBF1", "Thecamonas trahens ATCC 50062", "ecological metagenomes" ]

[ 559, 1, 1, 14 ]

4

[]

0

true

Family

Mercury ion transport, MerF

Mercury_ion_transport_MerF

1

IPR021093

21,093

NADH-quinone oxidoreductase, subunit15

NADH_quinone_OxRdtase_su15

Family

113

false

This entry represents subunit 15 of NADH-quinone oxidoreductase, also known as Complex I. The nqo15 subunit has probably a role in complex stabilisation, and may be also involved in the storage of iron for iron-sulphur cluster regeneration in the complex [ ].

[]

0

[ "PFAM" ]

[ "PF11497" ]

[ "NADH_Oxid_Nqo15" ]

[ 113 ]

1

[]

0

[ "2fug", "2ybb", "3i9v", "3iam", "3ias", "3m9s", "4hea", "6i0d", "6i1p", "6q8o", "6q8w", "6q8x", "6y11", "6ziy", "6zjl", "6zjn", "6zjy" ]

17

[ "PUB00005074", "PUB00040815", "PUB00043561", "PUB00045437" ]

[ "1470679", "16469879", "10940377", "18394423" ]

[ "The NADH:ubiquinone oxidoreductase (complex I) of respiratory chains.", "Structure of the hydrophilic domain of respiratory complex I from Thermus thermophilus.", "The respiratory complex I of bacteria, archaea and eukarya and its module common with membrane-bound multisubunit hydrogenases.", "Assembly of th...

[ 1992, 2006, 2000, 2008 ]

4

[]

0

null

[ "Deinococci" ]

[ 113 ]

1

[]

0

true

Family

NADH-quinone oxidoreductase, subunit15

NADH_quinone_OxRdtase_su15

3

IPR021094

21,094

NPR1/NIM1-like, C-terminal

NPR1/NIM1-like_C

Domain

2,287

false

This entry represents the NPR1/NIM1 like defence protein, which is found in many plant species [ ]. The eukaryotic proteins are typically between 251 and 588 amino acids in length. NPR1/NIM1 like defence protein mediates the binding of TGA factors to the as-1 motif, found in the pathogenesis-related PR-1 gene which lea...

[]

0

[ "PFAM" ]

[ "PF12313" ]

[ "NPR1_like_C" ]

[ 2287 ]

1

[]

0

[ "6wpg", "7mk2", "7mk3", "7tac", "7tad" ]

5

[ "PUB00053344", "PUB00053370" ]

[ "19064707", "12897257" ]

[ "Arabidopsis thaliana genes encoding defense signaling and recognition proteins exhibit contrasting evolutionary dynamics.", "Salicylic acid and NPR1 induce the recruitment of trans-activating TGA factors to a defense gene promoter in Arabidopsis." ]

[ 2009, 2003 ]

2

[]

0

null

[ "Embryophyta" ]

[ 2287 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 42, 6, 15 ]

3

true

Domain

NPR1/NIM1-like, C-terminal

NPR1/NIM1-like_C

3

IPR021096

21,096

Vibrio phage VSK, Orf152

Vibrio_phage_VSK_Orf152

Family

342

false

This entry is represented by Vibrio phage VSK, Orf152. The characteristics of the protein distribution suggest prophage matches in addition to the phage matches.

[]

0

[ "PFAM" ]

[ "PF12472" ]

[ "DUF3693" ]

[ 342 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Inoviridae", "ecological metagenomes" ]

[ 314, 2, 23, 3 ]

4

[]

0

true

Family

Vibrio phage VSK, Orf152

Vibrio_phage_VSK_Orf152

9

IPR021098

21,098

Bacteriophage P22, Gp10, DNA-stabilising

Phage_P22_Gp10

Family

1,080

false

This entry represents the Bacteriophage P22, Gp10, DNA-stabilising protein. The characteristics of the protein distribution suggest prophage matches in addition to the phage matches. Members of this family are phage proteins involved with stabilising the head assembly unit and condensed DNA within the capsid [ ].

[]

0

[ "PFAM" ]

[ "PF11134" ]

[ "Phage_stabilise" ]

[ 1080 ]

1

[]

0

[ "7eeq", "7sg7", "8eap", "8eb7", "8tvr", "8u10", "8u11", "9jg6" ]

8

[ "PUB00046122" ]

[ "1853558" ]

[ "Nucleotide sequence of the bacteriophage P22 genes required for DNA packaging." ]

[ 1991 ]

1

[]

0

null

[ "Bacteria", "Caudoviricetes", "Eukaryota", "metagenomes" ]

[ 857, 162, 3, 58 ]

4

[]

0

true

Family

Bacteriophage P22, Gp10, DNA-stabilising

Phage_P22_Gp10

1

IPR021100

21,100

N-glycosylation protein EOS1

N-glycosylation_EOS1

Family

1,378

false

The Saccharomyces cerevisiae EOS1 (Endoplasmic Reticulum-localised and Oxidants Sensitive) gene is not essential for cell growth, but the EOS1 deletion strain YNL080c confers, to some degree, a slow growth phenotype [ ]. The gene product, localised to the ER membrane, is involved in oxidative stress tolerance [ ], and ...

[ "GO:0034599", "GO:0005789" ]

[ "cellular response to oxidative stress", "endoplasmic reticulum membrane" ]

[ "biological_process", "cellular_component" ]

2

[ "PFAM", "PRINTS", "PANTHER" ]

[ "PF12326", "PR02070", "PTHR28147" ]

[ "EOS1", "NGLYCOSEOS1", "" ]

[ 1285, 203, 1184 ]

3

[]

0

[]

0

[ "PUB00053347" ]

[ "17187761" ]

[ "EOS1, whose deletion confers sensitivity to oxidative stress, is involved in N-glycosylation in Saccharomyces cerevisiae." ]

[ 2007 ]

1

[]

0

null

[ "Eukaryota" ]

[ 1378 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 1, 1 ]

3

true

Family

N-glycosylation protein EOS1

N-glycosylation_EOS1

7

IPR021101

21,101

Optomotor-blind protein, N-terminal

Optomoror-blind_N

Domain

302

false

Optomotor-blind is one of the essential toolkit proteins for coordinating development in diverse animal taxa. In Drosophila, where it has been characterised in the most detail, it plays a key role in establishing the abdominal pigmentation pattern, in development of the central nervous system and leg and wing imaginal ...

[]

0

[ "PFAM" ]

[ "PF11078" ]

[ "Optomotor-blind" ]

[ 302 ]

1

[ "REACTOME" ]

[ "R-DME-9856649" ]

[ "REACTOME:R-DME-9856649" ]

1

[]

0

[ "PUB00053348" ]

[ "15611170" ]

[ "Population genetics of the developmental gene optomotor-blind (omb) in Drosophila polymorpha: evidence for a role in abdominal pigmentation variation." ]

[ 2004 ]

1

[]

0

null

[ "Neoptera" ]

[ 302 ]

1

[ "Drosophila melanogaster" ]

[ 6 ]

1

true

Domain

Optomotor-blind protein, N-terminal

Optomoror-blind_N

8

IPR021102

21,102

Peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase A

PNGase_A

Family

4,576

false

Peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase A (PNGase A), unlike many other amidases, is capable of hydrolysing glycopeptides with an alpha-1,3-fucosylated asparagine-bound N-acetylglucosamine (GlcNAc). PNGase A is a heterodimer composed of a large and small subunit [ ]. This entry represents the PNGase A...

[]

0

[ "PANTHER" ]

[ "PTHR31104" ]

[ "" ]

[ 4576 ]

1

[]

0

[]

0

[ "PUB00053349" ]

[ "9523720" ]

[ "Characterisation of peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase A and its N-glycans." ]

[ 1998 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota" ]

[ 81, 667, 3828 ]

3

[ "Arabidopsis thaliana", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 8, 1, 14, 10 ]

4

true

Family

Peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase A

PNGase_A

4

IPR021103

21,103

Argonaute PAZ domain, archaea

PAZ_arc

Domain

6

false

This entry corresponds to the PAZ domain found in some archaeal argonaute proteins, such as and [ , ]. It is an siRNA binding domain.

[]

0

[ "PFAM" ]

[ "PF12212" ]

[ "PAZ_2" ]

[ 6 ]

1

[]

0

[ "1u04", "1z25", "1z26", "3da5", "8jpx", "8jsi", "8wd8" ]

7

[ "PUB00020002", "PUB00020128" ]

[ "14615801", "15284453" ]

[ "Structure and nucleic-acid binding of the Drosophila Argonaute 2 PAZ domain.", "Crystal structure of Argonaute and its implications for RISC slicer activity." ]

[ 2003, 2004 ]

2

[]

0

null

[ "Glomus cerebriforme", "Thermococcaceae" ]

[ 1, 5 ]

2

[]

0

true

Domain

Argonaute PAZ domain, archaea

PAZ_arc

6

IPR021104

21,104

KfrA, N-terminal DNA-binding domain

KfrA_DNA-bd_N

Domain

5,364

false

The KfrA family of proteins are encoded on plasmids, generally in or near gene clusters involved in stable inheritance functions. These proteins are thought to form an all-helical structure, consisting of an N-terminal helix-turn-helix DNA binding domain and an extended coiled-coil tail. The best-characterised KfrA pro...

[]

0

[ "PFAM" ]

[ "PF11740" ]

[ "KfrA_N" ]

[ 5364 ]

1

[]

0

[]

0

[ "PUB00053350" ]

[ "1602476" ]

[ "kfrA gene of broad host range plasmid RK2 encodes a novel DNA-binding protein." ]

[ 1992 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "plasmids", "unclassified sequences" ]

[ 5298, 11, 12, 43 ]

4

[]

0

true

Domain

KfrA, N-terminal DNA-binding domain

KfrA_DNA-bd_N

6

IPR021106

21,106

Protein Ste5, Fus3-binding domain

Ste5_Fus3-bd_dom

Domain

64

false

The Saccharomyces cerevisiae pheromone response pathway involves a cascade of 3 MAP kinases Ste11, Ste7, and Fus3. Ste5 is an essential element of this cascade, acting as a scaffold for each of the MAP kinases prior to signalling [ ]. This entry represents the Fus3-binding domain of Ste5, also known as the minimal scaf...

[]

0

[ "PFAM" ]

[ "PF12194" ]

[ "Ste5_C" ]

[ 64 ]

1

[]

0

[ "3fze", "4f2h" ]

2

[ "PUB00052084", "PUB00053351" ]

[ "19303851", "8943027" ]

[ "The Ste5 scaffold directs mating signaling by catalytically unlocking the Fus3 MAP kinase for activation.", "Dimerization of Ste5, a mitogen-activated protein kinase cascade scaffold protein, is required for signal transduction." ]

[ 2009, 1996 ]

2

[]

0

null

[ "Saccharomycetes" ]

[ 64 ]

1

[ "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)" ]

[ 1 ]

1

true

Domain

Protein Ste5, Fus3-binding domain

Ste5_Fus3-bd_dom

2

IPR021107

21,107

Restriction endonuclease, type II, HinP1I

Restrct_endonuc_II_HinP1I

Family

109

false

Hinp1I is a type II restriction endonuclease that recognises and cleaves a palindromic tetranucleotide sequence (G/CGC) resulting in 2 nt 5' overhanging ends [ ]. Structurally HinP1I consists of a conserved catalytic core domain, containing an active site motif SDC18QXK, and a DNA-binding domain [ ]. There are four cla...

[]

0

[ "PFAM" ]

[ "PF11463" ]

[ "R-HINP1I" ]

[ 109 ]

1

[]

0

[ "1ynm", "2fkc", "2fkh", "2fl3", "2flc" ]

5

[ "PUB00035691", "PUB00035692", "PUB00035693", "PUB00035694", "PUB00035705", "PUB00035707", "PUB00038569", "PUB00053352" ]

[ "15770420", "14576294", "11827971", "11557805", "15121719", "12665693", "15805123", "6262907" ]

[ "Type II restriction endonucleases: structure and mechanism.", "Diversity of type II restriction endonucleases that require two DNA recognition sites.", "Evolutionary relationship between different subgroups of restriction endonucleases.", "Structure and function of type II restriction endonucleases.", "S-A...

[ 2005, 2003, 2002, 2001, 2004, 2003, 2005, 1980 ]

8

[]

0

null

[ "Archaea", "Bacteria", "Glomeromycetes", "metagenomes" ]

[ 7, 92, 2, 8 ]

4

[]

0

true

Family

Restriction endonuclease, type II, HinP1I

Restrct_endonuc_II_HinP1I

6

IPR021108

21,108

Restriction endonuclease, type II, BpuJI, N-terminal

Restrct_endonuc_II_BpuJI_N

Domain

104

false

There are four classes of restriction endonucleases: types I, II, III and IV. All types of enzymes recognise specific short DNA sequences and carry out the endonucleolytic cleavage of DNA to give specific double-stranded fragments with terminal 5'-phosphates. They differ in their recognition sequence, subunit compositi...

[]

0

[ "PFAM" ]

[ "PF11564" ]

[ "BpuJI_N" ]

[ 104 ]

1

[]

0

[ "2vla", "5hlt", "5hnf", "5hnh" ]

4

[ "PUB00035691", "PUB00035692", "PUB00035693", "PUB00035694", "PUB00035705", "PUB00035707", "PUB00049789" ]

[ "15770420", "14576294", "11827971", "11557805", "15121719", "12665693", "18433771" ]

[ "Type II restriction endonucleases: structure and mechanism.", "Diversity of type II restriction endonucleases that require two DNA recognition sites.", "Evolutionary relationship between different subgroups of restriction endonucleases.", "Structure and function of type II restriction endonucleases.", "S-A...

[ 2005, 2003, 2002, 2001, 2004, 2003, 2008 ]

7

[]

0

null

[ "Bacteria", "Candidatus Nitrosotenuis uzonensis", "termite gut metagenome" ]

[ 102, 1, 1 ]

3

[]

0

true

Domain

Restriction endonuclease, type II, BpuJI, N-terminal

Restrct_endonuc_II_BpuJI_N

5

IPR021109

21,109

Aspartic peptidase domain superfamily

Peptidase_aspartic_dom_sf

Homologous_superfamily

677,057

false

This domain superfamily is found in aspartic peptidases, including pepsin A and other peptidase A1 family members, the yeast DNA-damage inducible protein 1 (Ddi1) (MEROPS peptidase subfamily A28A), animal retroviral-like aspartic protease (SASPase; MEROPS peptidase subfamily A28B) and Caulobacter PerP peptidase (MEROPS...

[]

0

[ "CATHGENE3D", "SSF" ]

[ "G3DSA:2.40.70.10", "SSF50630" ]

[ "", "" ]

[ 670056, 594783 ]

2

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", ...

[ "3.4.23", "R-CEL-2022377", "R-CEL-5683826", "R-CFA-1442490", "R-CFA-2022377", "R-CFA-2132295", "R-CFA-5683826", "R-CFA-6798695", "R-CFA-77387", "R-DDI-2132295", "R-DDI-5683826", "R-DDI-6798695", "R-GGA-2022377", "R-GGA-2132295", "R-GGA-6798695", "R-GGA-77387", "R-HSA-1442490", "R-H...

[ "EC:3.4.23", "REACTOME:R-CEL-2022377", "REACTOME:R-CEL-5683826", "REACTOME:R-CFA-1442490", "REACTOME:R-CFA-2022377", "REACTOME:R-CFA-2132295", "REACTOME:R-CFA-5683826", "REACTOME:R-CFA-6798695", "REACTOME:R-CFA-77387", "REACTOME:R-DDI-2132295", "REACTOME:R-DDI-5683826", "REACTOME:R-DDI-6798695...

51

[ "1a30", "1a8g", "1a8k", "1a94", "1a9m", "1aaq", "1aid", "1ajv", "1ajx", "1am5", "1apt", "1apu", "1apv", "1apw", "1avf", "1axa", "1az5", "1b11", "1b5f", "1b6j", "1b6k", "1b6l", "1b6m", "1b6p", "1bai", "1bbs", "1bdl", "1bdq", "1bdr", "1bil", "1bim", "1bv7"...

2,699

[ "PUB00000093", "PUB00000349", "PUB00000522", "PUB00001330", "PUB00011023", "PUB00011707", "PUB00021296", "PUB00041573", "PUB00042504", "PUB00065205", "PUB00066803", "PUB00076784", "PUB00076785", "PUB00076786" ]

[ "2194475", "1851433", "8439290", "6795036", "10331925", "11566868", "10864493", "17010377", "2682266", "23254940", "21765428", "4912600", "10497172", "21751400" ]

[ "The structure and function of the aspartic proteinases.", "Structural and evolutionary relationships between retroviral and eucaryotic aspartic proteinases.", "Evolutionary families of peptidases.", "Gastric proteinases--structure, function, evolution and mechanism of action.", "Crystal structure of the hy...

[ 1990, 1991, 1993, 1981, 1999, 2001, 2000, 2006, 1989, 2013, 2011, 1970, 1999, 2011 ]

14

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 649, 29227, 284030, 362745, 406 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 555, 24, 97, 46, 100, 85, 20, 1984, 45, 12, 16, 556 ]

12

true

Homologous_superfamily

Aspartic peptidase domain superfamily

Peptidase_aspartic_dom_sf

8

IPR021110

21,110

DNA replication/checkpoint protein

DNA_rep_checkpnt_protein

Family

2,145

false

Genome duplication is precisely regulated by cyclin-dependent kinases CDKs, which bring about the onset of S phase by activating replication origins and then prevent relicensing of origins until mitosis is completed. The optimum sequence motif for CDK phosphorylation is S/T-P-K/R-K/R, and Drc1-Sld2 is found to have at ...

[ "GO:0006260" ]

[ "DNA replication" ]

[ "biological_process" ]

1

[ "PFAM" ]

[ "PF11719" ]

[ "Drc1-Sld2" ]

[ 2145 ]

1

[]

0

[ "2kmu" ]

1

[ "PUB00053358", "PUB00053359", "PUB00099810", "PUB00099811" ]

[ "11937031", "17167415", "15317757", "29080750" ]

[ "CDK phosphorylation of Drc1 regulates DNA replication in fission yeast.", "CDK-dependent phosphorylation of Sld2 and Sld3 initiates DNA replication in budding yeast.", "RECQL4, mutated in the Rothmund-Thomson and RAPADILINO syndromes, interacts with ubiquitin ligases UBR1 and UBR2 of the N-end rule pathway.", ...

[ 2002, 2007, 2004, 2018 ]

4

[]

[ "IPR040203" ]

0

1

0

[ "Eukaryota", "Streptomyces actuosus", "bird metagenome" ]

[ 2143, 1, 1 ]

3

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 1, 1, 4, 1, 3, 1, 1 ]

8

true

Family

DNA replication/checkpoint protein

DNA_rep_checkpnt_protein

5

IPR021111

21,111

Hexameric tyrosine-coordinated heme protein (HTHP)

Hexamer_Tyr-coord_heme_pr_HTHP

Family

681

false

Hexameric tyrosine-coordinated heme protein (HTHP) is from the marine bacterium Silicibacter pomeroyi and has peroxidase and catalase activity. HTHP consists of six monomers which each binds a solvent accessible heme group and is stabilised by the interaction of three neighbouring monomers [ ]. The heme iron is penta-c...

[]

0

[ "PFAM" ]

[ "PF11534" ]

[ "HTHP" ]

[ 681 ]

1

[]

0

[ "2oyy" ]

1

[ "PUB00042306" ]

[ "17395199" ]

[ "HTHP: a novel class of hexameric, tyrosine-coordinated heme proteins." ]

[ 2007 ]

1

[]

0

null

[ "Bacteria", "ecological metagenomes" ]

[ 673, 8 ]

2

[]

0

true

Family

Hexameric tyrosine-coordinated heme protein (HTHP)

Hexamer_Tyr-coord_heme_pr_HTHP

1

IPR021112

21,112

Group II intron-interrupted relaxase LtrB, C-terminal domain

LtrB_C

Domain

538

false

This entry represents the C-terminal helical domain hairpin of Group II intron-interrupted relaxase LtrB from Lactococcus lactis and similar sequences from Lactobacillales. LtrB mediates initiation of the conjugal transfer of the plasmid pRS01 possibly by introducing a single-stranded nick at the potential origin of tr...

[]

0

[ "PFAM" ]

[ "PF11083" ]

[ "Relaxase_C" ]

[ 538 ]

1

[]

0

[]

0

[ "PUB00053373", "PUB00099846", "PUB00105889", "PUB00151930" ]

[ "11328600", "12369185", "31039174", "10532373" ]

[ "New gene cluster for lantibiotic streptin possibly involved in streptolysin S formation.", "Regulation of antimicrobial peptide production by autoinducer-mediated quorum sensing in lactic acid bacteria.", "The bacteriocin from the prophylactic candidate Streptococcus suis 90-1330 is widely distributed across S...

[ 2001, 2002, 2019, 1999 ]

4

[]

0

null

[ "Bacillota" ]

[ 538 ]

1

[]

0

true

Domain

Group II intron-interrupted relaxase LtrB, C-terminal domain

LtrB_C

9

IPR021114

21,114

Porin PorB/PorC

Porin_PorB/PorC

Family

123

false

This entry represents the putative cell wall channel-forming proteins porin B and porin C from Corynebacterium sp. Porin B from Corynebacterium glutamicum (Brevibacterium flavum) allows the exchange of material across the mycolic acid layer, which is the protective nonpolar barrier. Porin B has an α helical core struct...

[]

0

[ "PFAM" ]

[ "PF11565" ]

[ "PorB" ]

[ 123 ]

1

[]

0

[ "2vqg", "2vqh", "2vqk", "2vql" ]

4

[ "PUB00049855" ]

[ "18462756" ]

[ "A putative alpha-helical porin from Corynebacterium glutamicum." ]

[ 2008 ]

1

[]

0

null

[ "Corynebacterium" ]

[ 123 ]

1

[]

0

true

Family

Porin PorB/PorC

Porin_PorB/PorC

3

IPR021115

21,115

Pyridoxal-phosphate binding site

Pyridoxal-P_BS

Binding_site

25,433

false

Pyridoxal phosphate is the active form of vitamin B6 (pyridoxine or pyridoxal). Pyridoxal 5'-phosphate (PLP) is a versatile catalyst, acting as a coenzyme in a multitude of reactions, including decarboxylation, deamination and transamination [ , , ]. PLP-dependent enzymes are primarily involved in the biosynthesis of a...

[ "GO:0016831" ]

[ "carboxy-lyase activity" ]

[ "molecular_function" ]

1

[ "PROSITE" ]

[ "PS00392" ]

[ "DDC_GAD_HDC_YDC" ]

[ 25433 ]

1

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", ...

[ "4.1.1", "R-BTA-1614558", "R-BTA-70921", "R-BTA-888568", "R-BTA-888590", "R-BTA-8963693", "R-CFA-888568", "R-CFA-888590", "R-DME-209905", "R-DME-209931", "R-DME-70921", "R-DME-888568", "R-DME-888590", "R-HSA-1614558", "R-HSA-209905", "R-HSA-209931", "R-HSA-70921", "R-HSA-888568", ...

[ "EC:4.1.1", "REACTOME:R-BTA-1614558", "REACTOME:R-BTA-70921", "REACTOME:R-BTA-888568", "REACTOME:R-BTA-888590", "REACTOME:R-BTA-8963693", "REACTOME:R-CFA-888568", "REACTOME:R-CFA-888590", "REACTOME:R-DME-209905", "REACTOME:R-DME-209931", "REACTOME:R-DME-70921", "REACTOME:R-DME-888568", "REAC...

37

[ "1js3", "1js6", "1pmm", "1pmo", "1xey", "2dgk", "2dgl", "2dgm", "2okj", "2okk", "3fz6", "3fz7", "3fz8", "3k40", "3rbf", "3rbl", "3rch", "3vp6", "4e1o", "4obu", "4obv", "6eei", "6eem", "6eew", "6enz", "6jrl", "6khn", "6kho", "6khp", "6liu", "6liv", "6zek"...

50

[ "PUB00001452", "PUB00002358", "PUB00003414", "PUB00004715", "PUB00006322", "PUB00035504", "PUB00035505", "PUB00035506", "PUB00035507", "PUB00035508", "PUB00076906", "PUB00094543", "PUB00094588", "PUB00094589" ]

[ "8181483", "8889823", "2124279", "2300558", "7748903", "15581583", "8690703", "15189147", "17109392", "16763894", "24415726", "16766535", "22266321", "21283636" ]

[ "Multiple evolutionary origin of pyridoxal-5'-phosphate-dependent amino acid decarboxylases.", "Functionally important residues of aromatic L-amino acid decarboxylase probed by sequence alignment and site-directed mutagenesis.", "Prokaryotic and eukaryotic pyridoxal-dependent decarboxylases are homologous.", ...

[ 1994, 1996, 1990, 1990, 1995, 2005, 1995, 2004, 2006, 2006, 2014, 2006, 2012, 2011 ]

14

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 295, 5400, 19580, 158 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus",...

[ 6, 1, 17, 16, 2, 52, 13, 1, 12, 32, 16 ]

11

true

Binding_site

Pyridoxal-phosphate binding site

Pyridoxal-P_BS

5

IPR021116

21,116

Calcitonin/adrenomedullin

Family

4,127

false

Calcitonin [ ] is a 32 amino acid polypeptide hormone that causes a rapid but short-lived drop in the level of calcium and phosphate in the blood, by promoting the incorporation of these ions in the bones. This is the alpha type. Alternative splicing of the gene coding for calcitonin produces a distantly related peptid...

[ "GO:0005179", "GO:0005576" ]

[ "hormone activity", "extracellular region" ]

[ "molecular_function", "cellular_component" ]

2

[ "PFAM" ]

[ "PF00214" ]

[ "Calc_CGRP_IAPP" ]

[ 4127 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-418555", "R-BTA-419812", "R-BTA-9856530", "R-CFA-419812", "R-HSA-210745", "R-HSA-418555", "R-HSA-419812", "R-HSA-977225", "R-HSA-9856530", "R-MMU-418555", "R-MMU-419812", "R-MMU-9856530", "R-RNO-419812", "R-RNO-9856530", "R-SSC-418555", "R-SSC-419812", "R-SSC-9856530" ]

[ "REACTOME:R-BTA-418555", "REACTOME:R-BTA-419812", "REACTOME:R-BTA-9856530", "REACTOME:R-CFA-419812", "REACTOME:R-HSA-210745", "REACTOME:R-HSA-418555", "REACTOME:R-HSA-419812", "REACTOME:R-HSA-977225", "REACTOME:R-HSA-9856530", "REACTOME:R-MMU-418555", "REACTOME:R-MMU-419812", "REACTOME:R-MMU-9...

17

[ "1bku", "1byv", "1bzb", "1fb9", "2g48", "2glg", "2glh", "2kb8", "2kj7", "2l7s", "2l86", "3g7v", "3g7w", "3hgz", "4rwf", "5k5g", "5mgq", "6e3y", "6niy", "6ucj", "6uck", "6uun", "6uus", "6y1a", "6zrf", "6zrq", "6zrr", "7bg0", "7knu", "7m61", "7m62", "7m64"...

86

[ "PUB00000472", "PUB00002606" ]

[ "3060108", "2407732" ]

[ "Peptides from the calcitonin genes: molecular genetics, structure and function.", "Islet amyloid polypeptide. A new beta cell secretory product related to islet amyloid deposits." ]

[ 1988, 1990 ]

2

[]

[ "IPR001710", "IPR021117" ]

0

2

0

[ "Bilateria", "Pseudomonadota" ]

[ 4122, 5 ]

2

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 29, 10, 12, 16 ]

4

true

Family

Calcitonin/adrenomedullin

4

IPR021117

21,117

Calcitonin-like

Family

2,484

false

Calcitonin [ ] is a 32 amino acid polypeptide hormone that causes a rapid but short-lived drop in the level of calcium and phosphate in the blood, by promoting the incorporation of these ions in the bones. This is the alpha type. Alternative splicing of the gene coding for calcitonin produces a distantly related peptid...

[ "GO:0005179", "GO:0005576" ]

[ "hormone activity", "extracellular region" ]

[ "molecular_function", "cellular_component" ]

2

[ "PANTHER" ]

[ "PTHR10505" ]

[ "" ]

[ 2484 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-CFA-419812", "R-HSA-210745", "R-HSA-418555", "R-HSA-419812", "R-HSA-977225", "R-MMU-418555", "R-MMU-419812", "R-RNO-419812", "R-SSC-418555", "R-SSC-419812" ]

[ "REACTOME:R-CFA-419812", "REACTOME:R-HSA-210745", "REACTOME:R-HSA-418555", "REACTOME:R-HSA-419812", "REACTOME:R-HSA-977225", "REACTOME:R-MMU-418555", "REACTOME:R-MMU-419812", "REACTOME:R-RNO-419812", "REACTOME:R-SSC-418555", "REACTOME:R-SSC-419812" ]

10

[ "2g48", "2kb8", "2kj7", "2l86", "3hgz", "5k5g", "5mgq", "6e3y", "6ucj", "6uck", "6y1a", "6zrf", "6zrq", "6zrr", "7knu", "7m61", "7m62", "7m64", "7m65", "7tyf", "7tyi", "7tyl", "7tyx", "7tzf", "7ykw", "7yl0", "7yl3", "7yl7", "8awt", "8az0", "8az1", "8az2"...

69

[ "PUB00000472", "PUB00002606" ]

[ "3060108", "2407732" ]

[ "Peptides from the calcitonin genes: molecular genetics, structure and function.", "Islet amyloid polypeptide. A new beta cell secretory product related to islet amyloid deposits." ]

[ 1988, 1990 ]

2

[ "IPR021116" ]

[ "IPR000443", "IPR015476", "IPR021118" ]

1

3

0

[ "Vertebrata" ]

[ 2484 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 24, 7, 10, 12 ]

4

true

Family

Calcitonin-like

6

IPR021118

21,118

Calcitonin

Family

874

false

The calcitonin (CT) gene is alternatively expressed in a tissue-specific manner, producing either the calcium regulatory hormone CT in the thyroid, or the neuropeptide calcitonin gene related peptide (CGRP) in the brain [ ]. In medullary carcinoma of the thyroid, both peptides are produced [ ]. The calcitonin regulator...

[ "GO:0005179", "GO:0005576" ]

[ "hormone activity", "extracellular region" ]

[ "molecular_function", "cellular_component" ]

2

[ "PRINTS" ]

[ "PR00270" ]

[ "CALCITONINA" ]

[ 874 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-418555", "R-HSA-419812", "R-HSA-977225", "R-MMU-418555", "R-MMU-419812", "R-RNO-419812" ]

[ "REACTOME:R-HSA-418555", "REACTOME:R-HSA-419812", "REACTOME:R-HSA-977225", "REACTOME:R-MMU-418555", "REACTOME:R-MMU-419812", "REACTOME:R-RNO-419812" ]

6

[ "1bku", "1byv", "1bzb", "1fb9", "2glg", "2glh", "2jxz", "5ii0", "6niy", "7tyh", "7tyn", "7tyo", "7tyw", "7tyy" ]

14

[ "PUB00000335", "PUB00000472", "PUB00001543" ]

[ "1931969", "3060108", "2985435" ]

[ "Solution conformation of salmon calcitonin in sodium dodecyl sulfate micelles as determined by two-dimensional NMR and distance geometry calculations.", "Peptides from the calcitonin genes: molecular genetics, structure and function.", "A second human calcitonin/CGRP gene." ]

[ 1991, 1988, 1985 ]

3

[ "IPR021117" ]

[]

1

0

1

[ "Gnathostomata" ]

[ 874 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 18, 1, 3, 3 ]

4

true

Family

Calcitonin

1

IPR021119

21,119

Poxvirus F1/C10

Poxvirus_F1/C10

Family

228

false

This entry includes the poxvirus families F1 (also known as OPG045) and C10. C10 proteins are apoptosis regulators, which function to modulate the apoptotic cascades and thereby favour productive viral replication. One of these, M11L inhibits mitochondrial-dependent apoptosis by mimicking and competing with host protei...

[ "GO:0033668" ]

[ "symbiont-mediated suppression of host apoptosis" ]

[ "biological_process" ]

1

[ "PFAM" ]

[ "PF11099" ]

[ "M11L" ]

[ 228 ]

1

[]

0

[ "2jbx", "2jby", "2o42", "2vty", "4d2l", "4d2m", "4uf1", "4uf2", "4uf3", "5ajj", "5ajk", "6tqp", "6tqq", "6trr", "6xy4", "6xy6" ]

16

[ "PUB00048434", "PUB00088293", "PUB00088294" ]

[ "17384234", "23603272", "16439990" ]

[ "Structure of M11L: A myxoma virus structural homolog of the apoptosis inhibitor, Bcl-2.", "Vaccinia virus F1L protein promotes virulence by inhibiting inflammasome activation.", "Interaction of F1L with the BH3 domain of Bak is responsible for inhibiting vaccinia-induced apoptosis." ]

[ 2007, 2013, 2006 ]

3

[]

[ "IPR011207" ]

0

1

0

[ "Chordopoxvirinae" ]

[ 228 ]

1

[]

0

true

Family

Poxvirus F1/C10

Poxvirus_F1/C10

9

IPR021120

21,120

KduI/IolB isomerase

KduI/IolB_isomerase

Family

14,225

false

The KduI/IolB family of enzymes includes 5-keto 4-deoxyuronate isomerase (KduI) and 5-deoxy-glucuronate isomerase (IolB).

[ "GO:0016861" ]

[ "intramolecular oxidoreductase activity, interconverting aldoses and ketoses" ]

[ "molecular_function" ]

1

[ "PFAM" ]

[ "PF04962" ]

[ "KduI" ]

[ 14225 ]

1

[ "EC", "GP", "METACYC" ]

[ "5.3.1.17", "GenProp1286", "PWY-6507" ]

[ "EC:5.3.1.17", "GP:GenProp1286", "METACYC:PWY-6507" ]

3

[ "1x8m", "1xru", "1ywk", "2qjv", "7e4s", "7vgk", "7ye3", "7yrs", "9kcz", "9kd0" ]

10

[ "PUB00014561", "PUB00038353", "PUB00053908" ]

[ "1766386", "16152643", "18310071" ]

[ "Analysis of an Erwinia chrysanthemi gene cluster involved in pectin degradation.", "The crystal structure of 5-keto-4-deoxyuronate isomerase from Escherichia coli.", "myo-Inositol catabolism in Bacillus subtilis." ]

[ 1991, 2005, 2008 ]

3

[]

[ "IPR007045", "IPR024203" ]

0

2

0

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 10, 14064, 13, 138 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

KduI/IolB isomerase

KduI/IolB_isomerase

7

IPR021123

21,123

Type III secretion, needle-protein-like

T3SS_needle-like

Family

2,947

false

This entry represents bacterial type III secretion system needle-like proteins. Type III secretion systems are essential virulence determinants for many Gram-negative bacterial pathogens, acting to translocate proteins, usually virulence factors, out across both inner and outer membranes of bacteria and into the cytopl...

[ "GO:0015031" ]

[ "protein transport" ]

[ "biological_process" ]

1

[ "PFAM" ]

[ "PF09392" ]

[ "T3SS_needle_F" ]

[ 2947 ]

1

[ "REACTOME" ]

[ "R-HSA-844623" ]

[ "REACTOME:R-HSA-844623" ]

1

[ "2ca5", "2g0u", "2jow", "2kv7", "2lpz", "2mex", "2mme", "2p58", "2uwj", "2v6l", "2x9c", "3j0r", "6dwb", "6ofe", "6off", "6ofg", "6ofh", "6pep", "6q15", "6q16", "6rwy", "6znh", "6zni", "7agx", "7ah9", "7ahi", "7rye", "7y6c", "8axk", "8fvu" ]

30

[ "PUB00039947" ]

[ "16888041" ]

[ "Molecular model of a type III secretion system needle: Implications for host-cell sensing." ]

[ 2006 ]

1

[]

[ "IPR011841" ]

0

1

0

[ "Bacteria", "Bracon brevicornis", "metagenomes" ]

[ 2941, 1, 5 ]

3

[]

0

true

Family

Type III secretion, needle-protein-like

T3SS_needle-like

6

IPR021124

21,124

CRISPR-associated protein, Cas5

CRISPR-assoc_prot_Cas5

Family

7,137

false

This entry represents Cas5, which helps process or stabilize pre-crRNA into individual crRNA units. Cas5 and Cas6 are also required for optimal crRNA processing and/or stability [ ]. The CRISPR-Cas system is a prokaryotic defence mechanism against foreign genetic elements. The key elements of this defence system are th...

[ "GO:0043571" ]

[ "maintenance of CRISPR repeat elements" ]

[ "biological_process" ]

1

[ "PFAM" ]

[ "PF09704" ]

[ "Cas_Cas5d" ]

[ 7137 ]

1

[]

0

[ "3kg4", "3vzh", "3vzi", "4f3m", "4mjk", "4n77", "4qyz", "4r0j", "4tvx", "4u7u", "5cd4", "5h9e", "5h9f", "5u07", "5u0a", "6c66", "7kha", "8dej", "8dex", "8dfa", "8dfo", "8dfs", "8g9s", "8g9t", "8g9u", "8gaf", "8gam", "8gan", "8yb6", "8yha", "8zlu", "8zm3"...

36

[ "PUB00043286", "PUB00043287", "PUB00043288", "PUB00060621", "PUB00071890" ]

[ "17442114", "17379808", "16545108", "21699496", "24459147" ]

[ "Evolutionary conservation of sequence and secondary structures in CRISPR repeats.", "CRISPR provides acquired resistance against viruses in prokaryotes.", "A putative RNA-interference-based immune system in prokaryotes: computational analysis of the predicted enzymatic machinery, functional analogies with euka...

[ 2007, 2007, 2006, 2011, 2014 ]

5

[]

[ "IPR010147", "IPR010153", "IPR010155", "IPR013337", "IPR013421" ]

0

5

0

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 347, 6711, 7, 72 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

CRISPR-associated protein, Cas5

CRISPR-assoc_prot_Cas5

8

IPR021125

21,125

Protein of unknown function DUF2127

DUF2127

Family

2,334

false

There is currently no experimental data for members of this group or their homologues, nor do they exhibit features indicative of any function. However, they are predicted to be integral membrane proteins (with several transmembrane segments).

[]

0

[ "PFAM" ]

[ "PF09900" ]

[ "DUF2127" ]

[ 2334 ]

1

[]

0

[]

0

[]

0

[]

[ "IPR014511", "IPR014591" ]

0

2

0

[ "Bacteria", "Knufia peltigerae", "Stenosarchaea group", "ecological metagenomes" ]

[ 2312, 1, 2, 19 ]

4

[]

0

true

Family

Protein of unknown function DUF2127

DUF2127

8

IPR021126

21,126

Interferon gamma receptor, D2 domain, poxvirus/mammal

IFN_gamma_rc_D2_pox/mammal

Domain

421

false

Interferon (IFN)-gamma is a dimeric glycoprotein produced by activated T cells and natural killer cells. Although originally isolated based on its antiviral activity, IFN-gamma also displays powerful anti-proliferative and immunomodulatory activities, which are essential for developing appropriate cellular defences aga...

[ "GO:0004896", "GO:0060333" ]

[ "cytokine receptor activity", "type II interferon-mediated signaling pathway" ]

[ "molecular_function", "biological_process" ]

2

[ "PFAM" ]

[ "PF07140" ]

[ "IFNGR1_D2" ]

[ 421 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-877300", "R-HSA-877312", "R-HSA-9679191", "R-HSA-9732724", "R-MMU-877300", "R-MMU-877312", "R-MMU-9732724" ]

[ "REACTOME:R-HSA-877300", "REACTOME:R-HSA-877312", "REACTOME:R-HSA-9679191", "REACTOME:R-HSA-9732724", "REACTOME:R-MMU-877300", "REACTOME:R-MMU-877312", "REACTOME:R-MMU-9732724" ]

7

[ "1fg9", "1fyh", "3bes", "6e3k", "6e3l" ]

5

[ "PUB00009707", "PUB00011614", "PUB00011615", "PUB00019740", "PUB00099851" ]

[ "11842249", "7617032", "9367779", "10986460", "30814731" ]

[ "The vaccinia virus soluble interferon-gamma receptor is a homodimer.", "Crystal structure of a complex between interferon-gamma and its soluble high-affinity receptor.", "Neutralizing epitopes on the extracellular interferon gamma receptor (IFNgammaR) alpha-chain characterized by homolog scanning mutagenesis a...

[ 2002, 1995, 1997, 2000, 2019 ]

5

[]

0

null

[ "Chordopoxvirinae", "Tetrapoda" ]

[ 125, 296 ]

2

[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 18, 4, 5 ]

3

true

Domain

Interferon gamma receptor, D2 domain, poxvirus/mammal

IFN_gamma_rc_D2_pox/mammal

5

IPR021127

21,127

CRISPR-associated endonuclease Cas2

CRISPR_associated_Cas2

Family

10,074

false

This entry represents members of the family of Cas2, one of the first four protein families found to mark prokaryotic genomes that contain multiple CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) elements. CRISPR systems protect against invasive nucleic acid sequences, including phage. Cas2 proteins ...

[ "GO:0004521", "GO:0043571" ]

[ "RNA endonuclease activity", "maintenance of CRISPR repeat elements" ]

[ "molecular_function", "biological_process" ]

2

[ "HAMAP", "PIRSF", "PANTHER", "NCBIFAM", "CDD" ]

[ "MF_01471", "PIRSF032582", "PTHR34405", "TIGR01573", "cd09725" ]

[ "Cas2", "Cas2", "", "cas2", "Cas2_I_II_III" ]

[ 9021, 2797, 6462, 9719, 6755 ]

5

[ "GP", "GP", "GP", "GP", "GP", "GP", "GP", "GP", "GP", "GP", "GP" ]

[ "GenProp0021", "GenProp0313", "GenProp0314", "GenProp0317", "GenProp0318", "GenProp0319", "GenProp0320", "GenProp0469", "GenProp0768", "GenProp0922", "GenProp1061" ]

[ "GP:GenProp0021", "GP:GenProp0313", "GP:GenProp0314", "GP:GenProp0317", "GP:GenProp0318", "GP:GenProp0319", "GP:GenProp0320", "GP:GenProp0469", "GP:GenProp0768", "GP:GenProp0922", "GP:GenProp1061" ]

11

[ "1zpw", "2i0x", "2i8e", "2ivy", "3exc", "3oq2", "4es1", "4es2", "4es3", "4qr0", "4qr1", "4qr2", "4tno", "5g4d", "5h1o", "5h1p", "5xvn", "5xvo", "5xvp", "5zyf", "6jhz", "6k2e", "6qxf", "6qxt", "6qy3", "7cr6", "7cr8", "7ei1", "7f84", "7kft", "7kfu", "7mi4"...

43

[ "PUB00009737", "PUB00020781", "PUB00047685", "PUB00074066" ]

[ "11952905", "16292354", "18482976", "22942283" ]

[ "Identification of genes that are associated with DNA repeats in prokaryotes.", "A guild of 45 CRISPR-associated (Cas) protein families and multiple CRISPR/Cas subtypes exist in prokaryotic genomes.", "A novel family of sequence-specific endoribonucleases associated with the clustered regularly interspaced shor...

[ 2002, 2005, 2008, 2012 ]

4

[ "IPR019199" ]

[]

1

0

1

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 634, 9280, 25, 135 ]

4

[]

0

true

Family

CRISPR-associated endonuclease Cas2

CRISPR_associated_Cas2

4

IPR021130

21,130

Phosphoribosyl-ATP pyrophosphohydrolase-like

PRib-ATP_PPHydrolase-like

Family

30,716

false

Phosphoribosyl-ATP pyrophosphatase, catalyses the second step in the histidine biosynthetic pathway: 5-phosphoribosyl-ATP + H2O = 5-phosphoribosyl-AMP + PPi The Neurospora crassa enzyme also catalyzes the reactions of histidinol dehydrogenase ( ) and phosphoribosyl-AMP cyclohydrolase ( ). This entry also includes the B...

[]

0

[ "PFAM" ]

[ "PF01503" ]

[ "PRA-PH" ]

[ 30716 ]

1

[ "EC", "GP" ]

[ "3.6.1.31", "GenProp0109" ]

[ "EC:3.6.1.31", "GP:GenProp0109" ]

2

[ "1y6x", "1yvw", "1yxb", "2a7w", "2yeu", "2yf3", "2yf4", "2yf9", "2yfc", "2yfd", "3c90", "3nl9", "5hva", "5hwu", "5hx1", "5hyl", "5hzz", "5i0j", "5i0m", "6j22", "6j2l", "7bgm", "7bgn" ]

23

[ "PUB00053972" ]

[ "15292217" ]

[ "A genetic screen for the identification of thiamin metabolic genes." ]

[ 2004 ]

1

[]

[ "IPR008179", "IPR033653" ]

0

2

0

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 688, 26246, 2767, 558, 457 ]

5

[ "Arabidopsis thaliana", "Escherichia coli (strain K12)", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)", "Zea mays" ]

[ 7, 1, 1, 2, 1, 1, 4 ]

7

true

Family

Phosphoribosyl-ATP pyrophosphohydrolase-like

PRib-ATP_PPHydrolase-like

6

IPR021131

21,131

Large ribosomal subunit protein uL15/eL18

Ribosomal_uL15/eL18

Domain

43,416

false

This entry represents a domain conserved both in large ribosomal subunit proteins uL15 and eL18, which share a common structure consisting mainly of parallel β sheets (β-α-β units) with a core of three turns of irregular (β-β-α)n superhelix [ , ]. This entry includes uL15 proteins that were known as L15 from bacteria, ...

[]

0

[ "PFAM", "PFAM" ]

[ "PF00828", "PF17135" ]

[ "Ribosomal_L27A", "Ribosomal_L18" ]

[ 36339, 7077 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-156827", "R-BTA-1799339", "R-BTA-5389840", "R-BTA-5419276", "R-BTA-6791226", "R-BTA-72689", "R-BTA-72706", "R-BTA-9629569", "R-BTA-975956", "R-BTA-975957", "R-BTA-9937383", "R-CEL-156827", "R-CEL-1799339", "R-CEL-72689", "R-CEL-72706", "R-CEL-975956", "R-CEL-975957", "R-CFA-...

[ "REACTOME:R-BTA-156827", "REACTOME:R-BTA-1799339", "REACTOME:R-BTA-5389840", "REACTOME:R-BTA-5419276", "REACTOME:R-BTA-6791226", "REACTOME:R-BTA-72689", "REACTOME:R-BTA-72706", "REACTOME:R-BTA-9629569", "REACTOME:R-BTA-975956", "REACTOME:R-BTA-975957", "REACTOME:R-BTA-9937383", "REACTOME:R-CEL...

94

[ "1ffk", "1jj2", "1k73", "1k8a", "1k9m", "1kc8", "1kd1", "1kqs", "1m1k", "1m90", "1ml5", "1n8r", "1nji", "1nkw", "1nwx", "1nwy", "1q7y", "1q81", "1q82", "1q86", "1qvf", "1qvg", "1s72", "1sm1", "1vq4", "1vq5", "1vq6", "1vq7", "1vq8", "1vq9", "1vqk", "1vql"...

1,979

[ "PUB00007068", "PUB00007069", "PUB00007070", "PUB00034484", "PUB00041215" ]

[ "11297922", "11290319", "11114498", "16285925", "16713583" ]

[ "Atomic structures at last: the ribosome in 2000.", "The ribosome in focus.", "The end of the beginning: structural studies of ribosomal proteins.", "Structural insights into the roles of water and the 2' hydroxyl of the P site tRNA in the peptidyl transferase reaction.", "Elongation arrest by SecM via a ca...

[ 2001, 2001, 2000, 2005, 2006 ]

5

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 1824, 23483, 17572, 537 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus",...

[ 24, 4, 4, 6, 2, 18, 12, 3, 18, 27, 4, 5, 32 ]

13

true

Domain

Large ribosomal subunit protein uL15/eL18

Ribosomal_uL15/eL18

5