LiteFold/InterPro · Datasets at Hugging Face

IPR021132

21,132

Large ribosomal subunit protein eL18, conserved site

Ribosomal_eL18/eL18-A/B/_CS

Conserved_site

3,691

false

This signature covers a stretch of about 13 residues in the first third of teh members of the large ribosomal subunit protein eL18 family. Members of this family are large subunit ribosomal proteins which are found in eukaryotes and archaea [ , , ]. These proteins have 115 to 187 amino-acid residues. The family consist...

[ "GO:0003735", "GO:0006412", "GO:0005840" ]

[ "structural constituent of ribosome", "translation", "ribosome" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PROSITE" ]

[ "PS01106" ]

[ "RIBOSOMAL_L18E" ]

[ 3691 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-156827", "R-BTA-1799339", "R-BTA-6791226", "R-BTA-72689", "R-BTA-72706", "R-BTA-975956", "R-BTA-975957", "R-CFA-156827", "R-CFA-1799339", "R-CFA-6791226", "R-CFA-72689", "R-CFA-72706", "R-CFA-975956", "R-CFA-975957", "R-DME-156827", "R-DME-1799339", "R-DME-72689", "R-DME-727...

[ "REACTOME:R-BTA-156827", "REACTOME:R-BTA-1799339", "REACTOME:R-BTA-6791226", "REACTOME:R-BTA-72689", "REACTOME:R-BTA-72706", "REACTOME:R-BTA-975956", "REACTOME:R-BTA-975957", "REACTOME:R-CFA-156827", "REACTOME:R-CFA-1799339", "REACTOME:R-CFA-6791226", "REACTOME:R-CFA-72689", "REACTOME:R-CFA-72...

66

[ "1ffk", "1jj2", "1k73", "1k8a", "1k9m", "1kc8", "1kd1", "1kqs", "1m1k", "1m90", "1n8r", "1nji", "1q7y", "1q81", "1q82", "1q86", "1qvf", "1qvg", "1s72", "1vq4", "1vq5", "1vq6", "1vq7", "1vq8", "1vq9", "1vqk", "1vql", "1vqm", "1vqn", "1vqo", "1vqp", "1w2b"...

641

[ "PUB00000657", "PUB00007068", "PUB00007069", "PUB00007070", "PUB00059102", "PUB00101554" ]

[ "8218404", "11297922", "11290319", "11114498", "22096102", "32669547" ]

[ "Nucleotide and deduced amino acid sequence of human ribosomal protein L18.", "Atomic structures at last: the ribosome in 2000.", "The ribosome in focus.", "The end of the beginning: structural studies of ribosomal proteins.", "The structure of the eukaryotic ribosome at 3.0 A resolution.", "Structural sn...

[ 1993, 2001, 2001, 2000, 2011, 2020 ]

6

[]

0

null

[ "Archaea", "Eukaryota", "Pseudomonadati", "hydrocarbon metagenome" ]

[ 456, 3229, 4, 2 ]

4

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe ...

[ 1, 2, 8, 7, 1, 6, 8, 2, 2, 8 ]

10

true

Conserved_site

Large ribosomal subunit protein eL18, conserved site

Ribosomal_eL18/eL18-A/B/_CS

2

IPR021133

21,133

HEAT, type 2

HEAT_type_2

Repeat

75,429

false

The HEAT repeat is a tandemly repeated, 37-47 amino acid long module occurring in a number of cytoplasmic proteins, including the four name-giving proteins huntingtin, elongation factor 3 (EF3), the 65 kDa alpha regulatory subunit of protein phosphatase 2A (PP2A) and the yeast PI3-kinase TOR1 [ ]. Arrays of HEAT repeat...

[]

0

[ "PROFILE" ]

[ "PS50077" ]

[ "HEAT_REPEAT" ]

[ 75429 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-204626", "R-CEL-195253", "R-CEL-196299", "R-CEL-198753", "R-CEL-202670", "R-CEL-204626", "R-CEL-2995383", "R-CEL-389513", "R-CEL-5673000", "R-CEL-5675221", "R-CEL-6811558", "R-CEL-69231", "R-CEL-69273", "R-CEL-975957", "R-CEL-9833482", "R-CEL-9860927", "R-DDI-113501", "R-DDI...

[ "REACTOME:R-BTA-204626", "REACTOME:R-CEL-195253", "REACTOME:R-CEL-196299", "REACTOME:R-CEL-198753", "REACTOME:R-CEL-202670", "REACTOME:R-CEL-204626", "REACTOME:R-CEL-2995383", "REACTOME:R-CEL-389513", "REACTOME:R-CEL-5673000", "REACTOME:R-CEL-5675221", "REACTOME:R-CEL-6811558", "REACTOME:R-CEL...

326

[ "1b3u", "1c9i", "1c9l", "1f59", "1gcj", "1ibr", "1m5n", "1o6o", "1o6p", "1qgk", "1qgr", "1ukl", "2bku", "2db0", "2iae", "2ie3", "2ie4", "2iw3", "2iwh", "2ix3", "2ix8", "2npp", "2nyl", "2nym", "2p8q", "2pf4", "2pkg", "2q5d", "2qk1", "2qk2", "2qna", "2xzg"...

193

[ "PUB00006179", "PUB00006180" ]

[ "7550332", "9989501" ]

[ "HEAT repeats in the Huntington's disease protein.", "The structure of the protein phosphatase 2A PR65/A subunit reveals the conformation of its 15 tandemly repeated HEAT motifs." ]

[ 1995, 1999 ]

2

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "metagenomes" ]

[ 544, 5273, 69425, 2, 185 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 90, 14, 156, 21, 86, 69, 8, 50, 91, 10, 7, 293 ]

12

true

Repeat

HEAT, type 2

HEAT_type_2

3

IPR021134

21,134

Bestrophin-like

Family

9,228

false

This entry represents animal bestrophin homologues. Bestrophin is a 68kDa basolateral plasma membrane protein expressed in retinal pigment epithelial cells (RPE). It is encoded by the VMD2 gene, which is mutated in Best macular dystrophy, a disease characterised by a depressed light peak in the electrooculogram [ ]. VM...

[ "GO:0005254" ]

[ "chloride channel activity" ]

[ "molecular_function" ]

1

[ "PFAM" ]

[ "PF01062" ]

[ "Bestrophin" ]

[ 9228 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-2672351", "R-HSA-2672351", "R-MMU-2672351", "R-SSC-2672351" ]

[ "REACTOME:R-BTA-2672351", "REACTOME:R-HSA-2672351", "REACTOME:R-MMU-2672351", "REACTOME:R-SSC-2672351" ]

4

[ "4rdq", "5t5n", "6n23", "6n24", "6n25", "6n26", "6n27", "6n28", "6vx5", "6vx6", "6vx7", "6vx8", "6vx9", "8d1e", "8d1f", "8d1g", "8d1h", "8d1i", "8d1j", "8d1k", "8d1l", "8d1m", "8d1n", "8d1o", "8ecy", "9ctq", "9ctr", "9cts", "9ctt", "9dyh", "9dyi", "9dyj"...

45

[ "PUB00011864", "PUB00011865", "PUB00096747", "PUB00096748", "PUB00096752", "PUB00103559", "PUB00103560", "PUB00109156" ]

[ "12032738", "12058047", "12907679", "18400985", "25337878", "31263784", "35523970", "19398034" ]

[ "Three novel human VMD2-like genes are members of the evolutionary highly conserved RFP-TM family.", "Bestrophin interacts physically and functionally with protein phosphatase 2A.", "Structure-function analysis of the bestrophin family of anion channels.", "Bestrophin Cl- channels are highly permeable to HCO3...

[ 2002, 2002, 2003, 2008, 2014, 2019, 2022, 2009 ]

8

[]

[ "IPR000615", "IPR044669" ]

0

2

0

[ "Eukaryota" ]

[ 9228 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 33, 11, 9, 23, 5, 10 ]

6

true

Family

Bestrophin-like

2

IPR021135

21,135

Phosphoenolpyruvate carboxylase

PEP_COase

Family

23,232

false

Phosphoenolpyruvate carboxylase (PEPCase), an enzyme found in all multicellular plants, catalyses the formation of oxaloacetate from phosphoenolpyruvate (PEP) and a hydrocarbonate ion [ ]. This reaction is harnessed by C4 plants to capture and concentrate carbon dioxide into the photosynthetic bundle sheath cells. It a...

[ "GO:0008964", "GO:0006099", "GO:0015977" ]

[ "phosphoenolpyruvate carboxylase activity", "tricarboxylic acid cycle", "carbon fixation" ]

[ "molecular_function", "biological_process", "biological_process" ]

3

[ "PFAM", "PRINTS", "PANTHER" ]

[ "PF00311", "PR00150", "PTHR30523" ]

[ "PEPcase", "PEPCARBXLASE", "" ]

[ 23214, 20162, 23031 ]

3

[ "EC", "GP", "GP", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC" ]

[ "4.1.1.31", "GenProp1267", "GenProp1669", "PWY-1622", "PWY-241", "PWY-5913", "PWY-6142", "PWY-6146", "PWY-6549", "PWY-7115", "PWY-7117", "PWY-7124" ]

[ "EC:4.1.1.31", "GP:GenProp1267", "GP:GenProp1669", "METACYC:PWY-1622", "METACYC:PWY-241", "METACYC:PWY-5913", "METACYC:PWY-6142", "METACYC:PWY-6146", "METACYC:PWY-6549", "METACYC:PWY-7115", "METACYC:PWY-7117", "METACYC:PWY-7124" ]

12

[ "1fiy", "1jqn", "1jqo", "1qb4", "3zgb", "3zge", "4bxc", "4bxh", "5fdn", "5vyj", "6mgi", "6u2t", "6v3o", "8cj5", "8cj8", "8oj9", "8oje", "8ojf", "8ojq", "8ojy", "8ojz", "8qtm", "8qx1", "8qx3" ]

24

[ "PUB00003734", "PUB00003752", "PUB00004559", "PUB00004561" ]

[ "2779518", "1508152", "1421147", "1450389" ]

[ "The phosphoenolpyruvate carboxylase gene of Corynebacterium glutamicum: molecular cloning, nucleotide sequence, and expression.", "Homologous genes for the C4 isoform of phosphoenolpyruvate carboxylase in a C3 and a C4 Flaveria species.", "Alfalfa root nodule phosphoenolpyruvate carboxylase: characterization o...

[ 1989, 1992, 1992, 1992 ]

4

[]

[ "IPR022805" ]

0

1

0

[ "Bacteria", "Eukaryota", "Methanobacteriati", "unclassified sequences" ]

[ 15863, 6771, 326, 272 ]

4

[ "Arabidopsis thaliana", "Escherichia coli (strain K12)", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 14, 1, 29, 77 ]

4

true

Family

Phosphoenolpyruvate carboxylase

PEP_COase

9

IPR021138

21,138

Large ribosomal subunit protein eL20, eukaryota

Ribosomal_eL20_euk

Family

6,412

false

This entry represent the 60S ribosomal protein eL20 (also known as L20 and previously known as 60S ribosomal protein L18a) from eukaryotes. Ribosomes are the particles that catalyse mRNA-directed protein synthesis in all organisms. The codons of the mRNA are exposed on the ribosome to allow tRNA binding. This leads to ...

[ "GO:0003735", "GO:0006412", "GO:0005840" ]

[ "structural constituent of ribosome", "translation", "ribosome" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PIRSF", "PANTHER" ]

[ "PIRSF002190", "PTHR10052" ]

[ "Ribosomal_L18a", "" ]

[ 5048, 6412 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-156827", "R-BTA-1799339", "R-BTA-6791226", "R-BTA-72689", "R-BTA-72706", "R-BTA-975956", "R-BTA-975957", "R-CEL-156827", "R-CEL-1799339", "R-CEL-72689", "R-CEL-72706", "R-CEL-975956", "R-CEL-975957", "R-DDI-156827", "R-DDI-1799339", "R-DDI-72689", "R-DDI-72706", "R-DDI-97595...

[ "REACTOME:R-BTA-156827", "REACTOME:R-BTA-1799339", "REACTOME:R-BTA-6791226", "REACTOME:R-BTA-72689", "REACTOME:R-BTA-72706", "REACTOME:R-BTA-975956", "REACTOME:R-BTA-975957", "REACTOME:R-CEL-156827", "REACTOME:R-CEL-1799339", "REACTOME:R-CEL-72689", "REACTOME:R-CEL-72706", "REACTOME:R-CEL-9759...

69

[ "3j6x", "3j6y", "3j77", "3j78", "3j79", "3j7o", "3j7p", "3j7q", "3j7r", "3j92", "3jag", "3jah", "3jai", "3jaj", "3jan", "3jbn", "3jbo", "3jbp", "3jcs", "3jct", "4d5y", "4d67", "4u3m", "4u3n", "4u3u", "4u4n", "4u4o", "4u4q", "4u4r", "4u4u", "4u4y", "4u4z"...

584

[ "PUB00000194", "PUB00006236", "PUB00007068", "PUB00007069", "PUB00007070", "PUB00068015" ]

[ "1840484", "3371159", "11297922", "11290319", "11114498", "9559554" ]

[ "The primary structure of rat ribosomal protein L38.", "The primary structure of rat ribosomal protein L18.", "Atomic structures at last: the ribosome in 2000.", "The ribosome in focus.", "The end of the beginning: structural studies of ribosomal proteins.", "The list of cytoplasmic ribosomal proteins of ...

[ 1991, 1988, 2001, 2001, 2000, 1998 ]

6

[ "IPR028877" ]

[]

1

0

1

[ "Bacteria", "Eukaryota" ]

[ 3, 6409 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 11, 1, 1, 1, 12, 8, 2, 6, 8, 2, 2, 23 ]

12

true

Family

Large ribosomal subunit protein eL20, eukaryota

Ribosomal_eL20_euk

1

IPR021139

21,139

NYN domain

NYN

Domain

33,781

false

This NYN domain is found in Meiosis regulator and mRNA stability factor 1 (MARF1, also known as limkain-b1) [ , ] and some bacterial sequences. The NYN domains are found in the eukaryotic proteins typified by the Nedd4-binding protein 1 and the bacterial YacP-like proteins. The NYN (for Nedd4-BP1, YacP-like Nuclease) d...

[ "GO:0004540" ]

[ "RNA nuclease activity" ]

[ "molecular_function" ]

1

[ "PFAM" ]

[ "PF01936" ]

[ "NYN" ]

[ 33781 ]

1

[]

0

[ "2qip", "5yaa", "6fdl" ]

3

[ "PUB00056072", "PUB00056584", "PUB00098862" ]

[ "15932519", "17114934", "30333187" ]

[ "Limkain b1, a novel human autoantigen localized to a subset of ABCD3 and PXF marked peroxisomes.", "The NYN domains: novel predicted RNAses with a PIN domain-like fold.", "Ribonuclease activity of MARF1 controls oocyte RNA homeostasis and genome integrity in mice." ]

[ 2005, 2006, 2018 ]

3

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 1037, 23219, 9125, 25, 375 ]

5

[ "Arabidopsis thaliana", "Danio rerio", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 122, 12, 3, 3, 16, 5, 24 ]

7

true

Domain

NYN domain

NYN

2

IPR021140

21,140

Alkaline proteinase inhibitor/ Outer membrane lipoprotein Omp19

Inh/Omp19

Domain

2,237

false

This entry represents the metalloprotease inhibitor I38, as well as the outer membrane lipoprotein Omp19. This family of proteins represent monomeric serralysin inhibitors of about 125 residues, which interact with specific metalloprotease which are synthesised by serralysin secretors and characterised by being plant, ...

[]

0

[ "PFAM" ]

[ "PF02974" ]

[ "Inh" ]

[ 2237 ]

1

[]

0

[ "1jiw", "1smp", "2rn4", "6ixx", "6iy4", "7mhw" ]

6

[ "PUB00000545", "PUB00005013", "PUB00006323", "PUB00015040" ]

[ "8761444", "7684291", "7752231", "10770939" ]

[ "The lipocalin protein family: structure and function.", "Structure and sequence relationships in the lipocalins and related proteins.", "Crystal structure of a complex between Serratia marcescens metallo-protease and an inhibitor from Erwinia chrysanthemi.", "Alkaline proteinase inhibitor of Pseudomonas aeru...

[ 1996, 1993, 1995, 2000 ]

4

[]

0

null

[ "Bacteria", "ecological metagenomes" ]

[ 2233, 4 ]

2

[]

0

true

Domain

Alkaline proteinase inhibitor/ Outer membrane lipoprotein Omp19

Inh/Omp19

2

IPR021143

21,143

Pyrimidine dimer DNA glycosylase, endonuclease V type

Pyr-dimer_DNAGlyclase_EndonucV

Family

190

false

Pyrimidine dimer DNA glycosylases are enzymes responsible for initiating the base excision repair pathway, excising pyrimidine dimers by hydrolysis of the glycosylic bond of the 5' pyrimidine, followed by the intra-pyrimidine phosphodiester bond [ ]. One such enzyme is T4 endonuclease V, an enzyme responsible for the f...

[]

0

[ "PIRSF" ]

[ "PIRSF500103" ]

[ "EndoV" ]

[ 190 ]

1

[]

0

[ "1eni", "1enj", "1enk", "1vas", "2end", "2fcc" ]

6

[ "PUB00007456", "PUB00015082" ]

[ "2067549", "11148051" ]

[ "Site-directed deletion mutagenesis within the T4 endonuclease V gene: dispensable sequences within putative loop regions.", "The reaction mechanism of DNA glycosylase/AP lyases at abasic sites." ]

[ 1991, 2001 ]

2

[ "IPR004260" ]

[]

1

0

1

[ "Caudoviricetes", "Pseudomonadota" ]

[ 152, 38 ]

2

[]

0

true

Family

Pyrimidine dimer DNA glycosylase, endonuclease V type

Pyr-dimer_DNAGlyclase_EndonucV

6

IPR021144

21,144

Uncharacterised protein family UPF0597

UPF0597

Family

4,562

false

This family consists of several hypothetical proteins of unknown function from bacteria and L-cysteine desulfidases from the archaea Methanocaldococcus [ ].

[]

0

[ "HAMAP", "PIRSF", "PANTHER" ]

[ "MF_01845", "PIRSF006054", "PTHR30501" ]

[ "UPF0597", "UCP006054", "" ]

[ 4125, 4219, 4561 ]

3

[]

0

[ "9fsl", "9fyi", "9he0", "9he2" ]

4

[ "PUB00074297" ]

[ "15683250" ]

[ "L-cysteine desulfidase: an [4Fe-4S] enzyme isolated from Methanocaldococcus jannaschii that catalyzes the breakdown of L-cysteine into pyruvate, ammonia, and sulfide." ]

[ 2005 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "Methanobacteriota", "unclassified sequences" ]

[ 4436, 6, 33, 87 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Uncharacterised protein family UPF0597

UPF0597

7

IPR021145

21,145

Portal protein SPP1 Gp6-like

Portal_protein_SPP1_Gp6-like

Family

6,981

false

The bacteriophage portal protein forms a gateway, or portal, enabling DNA passage during packaging and ejection of the phage genome. It also forms the junction between the phage head (capsid) and the tail proteins [ ]. During SPP1 morphogenesis, Gp6 participates in the procapsid assembly reaction [ , ]. In the mature S...

[]

0

[ "PFAM" ]

[ "PF05133" ]

[ "SPP1_portal" ]

[ 6981 ]

1

[ "GP" ]

[ "GenProp0208" ]

[ "GP:GenProp0208" ]

1

[ "2jes", "5a20", "5a21", "7z4w", "8v8b", "8vd8", "8vdc", "8vde", "8zdj", "8zdl", "9d94", "9d9w", "9gb3", "9gb4", "9gb5", "9gb7" ]

16

[ "PUB00020097", "PUB00047888", "PUB00082571" ]

[ "11501993", "17363899", "25991862" ]

[ "Structural organisation of the head-to-tail interface of a bacterial virus.", "Structural framework for DNA translocation via the viral portal protein.", "Structural rearrangements in the phage head-to-tail interface during assembly and infection." ]

[ 2001, 2007, 2015 ]

3

[]

[ "IPR006428", "IPR006432" ]

0

2

0

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "metagenomes" ]

[ 5, 5117, 13, 1755, 91 ]

5

[]

0

true

Family

Portal protein SPP1 Gp6-like

Portal_protein_SPP1_Gp6-like

7

IPR021146

21,146

Phage gp6-like head-tail connector protein

Phage_gp6-like_head-tail

Family

7,407

false

This family of proteins contain head-tail connector proteins related to gp6 from bacteriophage HK97 [ ]. The gp15 protein of Bacillus phage SPP1, for which the tertiary structure is known, is included in this entry [ ]. This family contain head-tail connector proteins related to gp6 from bacteriophage HK97 [ ]. These p...

[]

0

[ "PFAM" ]

[ "PF05135" ]

[ "Phage_connect_1" ]

[ 7407 ]

1

[]

0

[ "2kbz", "3jvo", "5a20", "5a21", "7z4w", "8vd8", "8vdc", "9mu2", "9mu3" ]

9

[ "PUB00048313", "PUB00067867", "PUB00096391" ]

[ "19433794", "19895817", "24198424" ]

[ "Structure of bacteriophage SPP1 head-to-tail connection reveals mechanism for viral DNA gating.", "The crystal structure of bacteriophage HK97 gp6: defining a large family of head-tail connector proteins.", "Insights into bacteriophage T5 structure from analysis of its morphogenesis genes and protein component...

[ 2009, 2010, 2014 ]

3

[]

[ "IPR006450", "IPR011738", "IPR047186" ]

0

3

0

[ "Bacteria", "Eukaryota", "Viruses", "metagenomes" ]

[ 6553, 15, 743, 96 ]

4

[]

0

true

Family

Phage gp6-like head-tail connector protein

Phage_gp6-like_head-tail

3

IPR021147

21,147

Protein of unknown function DUF697

DUF697

Family

8,013

false

Proteins in this entry have no known function.

[]

0

[ "PFAM" ]

[ "PF05128" ]

[ "DUF697" ]

[ 8013 ]

1

[]

0

[]

0

[]

0

[]

[ "IPR006507" ]

0

1

0

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 7938, 27, 48 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Protein of unknown function DUF697

DUF697

8

IPR021148

21,148

Polysaccharide biosynthesis domain

Polysacc_synth_dom

Domain

3,351

false

This entry includes PBDC1 protein from mammals and its homologues from fungi. Protein PBDC1 homolog from S. cerevisiae also known as Ypl225w (Chp1, Chaperone 1 for eEF1A) functions as a co-translational chaperone by forming dual interactions with the eEF1A G domain nascent chain and the UBA domain of ribosome-bound nas...

[]

0

[ "PFAM" ]

[ "PF04669" ]

[ "PBDC1" ]

[ 3351 ]

1

[]

0

[ "2jyn" ]

1

[ "PUB00076852", "PUB00076853", "PUB00160075", "PUB00160942" ]

[ "23045523", "24576763", "39900909", "38360885" ]

[ "Three Arabidopsis DUF579 domain-containing GXM proteins are methyltransferases catalyzing 4-o-methylation of glucuronic acid on xylan.", "Modification of the degree of 4-O-methylation of secondary wall glucuronoxylan.", "A ribosome-associating chaperone mediates GTP-driven vectorial folding of nascent eEF1A.",...

[ 2012, 2014, 2025, 2024 ]

4

[]

0

null

[ "Eukaryota" ]

[ 3351 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strai...

[ 1, 1, 2, 4, 1, 1, 4, 1, 1 ]

9

true

Domain

Polysaccharide biosynthesis domain

Polysacc_synth_dom

3

IPR021149

21,149

MAGT1/OST3/OST6

Family

8,534

false

During N-linked glycosylation of proteins, oligosaccharide chains are assembled on the carrier molecule dolichyl pyrophosphate in the following order: 2 molecules of N-acetylglucosamine (GlcNAc), 9 molecules of mannose, and 3 molecules of glucose. These 14-residue oligosaccharide cores are then transferred to asparagin...

[]

0

[ "PFAM" ]

[ "PF04756" ]

[ "OST3_OST6" ]

[ 8534 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-9768727", "R-CEL-5223345", "R-CEL-6798695", "R-CFA-9768727", "R-DDI-5223345", "R-DDI-6798695", "R-DME-9768727", "R-DRE-5223345", "R-DRE-6798695", "R-DRE-9768727", "R-GGA-9768727", "R-HSA-446203", "R-HSA-5223345", "R-HSA-6798695", "R-HSA-9694548", "R-HSA-9768727", "R-MMU-522334...

[ "REACTOME:R-BTA-9768727", "REACTOME:R-CEL-5223345", "REACTOME:R-CEL-6798695", "REACTOME:R-CFA-9768727", "REACTOME:R-DDI-5223345", "REACTOME:R-DDI-6798695", "REACTOME:R-DME-9768727", "REACTOME:R-DRE-5223345", "REACTOME:R-DRE-6798695", "REACTOME:R-DRE-9768727", "REACTOME:R-GGA-9768727", "REACTOM...

26

[ "3g7y", "3g9b", "3ga4", "4m8g", "4m90", "4m91", "4m92", "6c26", "6ezn", "6ftg", "6fti", "6ftj", "6s7o", "6s7t", "7oci", "8agb", "8agc", "8age", "8b6l", "8pn9" ]

20

[ "PUB00008612", "PUB00008613", "PUB00020140", "PUB00054184", "PUB00054185" ]

[ "7622558", "10358084", "9878760", "15831493", "8472892" ]

[ "Functional characterization of Ost3p. Loss of the 34-kD subunit of the Saccharomyces cerevisiae oligosaccharyltransferase results in biased underglycosylation of acceptor substrates.", "The oligosaccharyltransferase complex from Saccharomyces cerevisiae. Isolation of the OST6 gene, its synthetic interaction with...

[ 1995, 1999, 1999, 2005, 1993 ]

5

[]

[ "IPR042416" ]

0

1

0

[ "Archaea", "Desulfofervidus auxilii", "Eukaryota", "marine sediment metagenome" ]

[ 26, 1, 8503, 4 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 18, 1, 3, 2, 20, 7, 1, 4, 14, 2, 1, 9 ]

12

true

Family

MAGT1/OST3/OST6

2

IPR021150

21,150

Ubiquinol-cytochrome c chaperone

Ubiq_cyt_c_chap

Domain

7,658

false

Saccharomyces cerevisiae ubiquinol-cytochrome C chaperone (CBP3) is required for assembly of coenzyme QF-2-cytochrome C reductase. This protein is organised into two domains: a variable N-terminal domain of unknown function present in mitochondrial Cbp3 homologues and a conserved C-terminal ubiquinol-cytochrome c chape...

[]

0

[ "PFAM" ]

[ "PF03981" ]

[ "Ubiq_cyt_C_chap" ]

[ 7658 ]

1

[ "REACTOME", "REACTOME" ]

[ "R-HSA-9865881", "R-SCE-9865878" ]

[ "REACTOME:R-HSA-9865881", "REACTOME:R-SCE-9865878" ]

2

[ "6rwt" ]

1

[ "PUB00100678" ]

[ "31537648" ]

[ "Structural basis for the interaction of the chaperone Cbp3 with newly synthesized cytochrome b during mitochondrial respiratory chain assembly." ]

[ 2019 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "Myoviridae sp. ctoNH1", "metagenomes" ]

[ 2917, 4711, 1, 29 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus",...

[ 7, 1, 1, 1, 1, 11, 6, 1, 3, 8, 1, 1, 17 ]

13

true

Domain

Ubiquinol-cytochrome c chaperone

Ubiq_cyt_c_chap

3

IPR021153

21,153

Heat-inducible transcription repressor HrcA, C-terminal

HrcA_C

Domain

17,416

false

This entry represents the C-terminal of HrcA, consisting of the GAF-like domain with the inserted dimerising domain. Prokaryotic cells have a defence mechanism against a sudden heat-shock stress. Commonly, they induce a set of proteins that protect cellular proteins from being denatured by heat. Among such proteins are...

[ "GO:0003677", "GO:0006355" ]

[ "DNA binding", "regulation of DNA-templated transcription" ]

[ "molecular_function", "biological_process" ]

2

[ "PFAM" ]

[ "PF01628" ]

[ "HrcA" ]

[ 17416 ]

1

[]

0

[ "1stz" ]

1

[ "PUB00037641", "PUB00053432", "PUB00053433" ]

[ "15979091", "19277496", "12486078" ]

[ "Crystal structure of a heat-inducible transcriptional repressor HrcA from Thermotoga maritima: structural insight into DNA binding and dimerization.", "Reduction-sensitive and cysteine residue-mediated Streptococcus pneumoniae HrcA oligomerization in vitro.", "Identification of a helix-turn-helix motif of Baci...

[ 2005, 2009, 2003 ]

3

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 16931, 34, 451 ]

3

[]

0

true

Domain

Heat-inducible transcription repressor HrcA, C-terminal

HrcA_C

7

IPR021155

21,155

Poxvirus E2/O1

Poxvirus_E2/O1

Family

439

false

The function of the E2 and O1 viral proteins is not known.

[]

0

[ "PFAM" ]

[ "PF04497" ]

[ "Pox_E2-like" ]

[ 439 ]

1

[]

0

[ "7phy" ]

1

[]

0

[]

[ "IPR006732", "IPR007585" ]

0

2

0

[ "Poxviridae" ]

[ 439 ]

1

[]

0

true

Family

Poxvirus E2/O1

Poxvirus_E2/O1

2

IPR021156

21,156

Transcription elongation factor A-like/Brain expressed X-linked

TF_A-like/BEX

Family

2,262

false

This is a family of transcription elongation factors which includes those referred to as Bex (brain-expressed X-linked) proteins as well as those named TCEAL (transcription elongation factor A protein-like). Bex proteins are expressed in a wide range of tissues and are known to play a role in neuronal development. They...

[]

0

[ "PFAM" ]

[ "PF04538" ]

[ "BEX" ]

[ 2262 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-205025", "R-HSA-205025", "R-MMU-205025", "R-RNO-205025" ]

[ "REACTOME:R-BTA-205025", "REACTOME:R-HSA-205025", "REACTOME:R-MMU-205025", "REACTOME:R-RNO-205025" ]

4

[]

0

[ "PUB00073473", "PUB00076348", "PUB00080719", "PUB00080723", "PUB00080724" ]

[ "16498402", "10051408", "19966855", "26408910", "15870691" ]

[ "Bex1, a novel interactor of the p75 neurotrophin receptor, links neurotrophin signaling to the cell cycle.", "Genomic structure and chromosomal localization of TCEAL1, a human gene encoding the nuclear phosphoprotein p21/SIIR.", "TCEAL7, a putative tumor suppressor gene, negatively regulates NF-kappaB pathway....

[ 2006, 1999, 2010, 2015, 2005 ]

5

[]

[ "IPR007623" ]

0

1

0

[ "Bilateria" ]

[ 2262 ]

1

[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 18, 16, 22 ]

3

true

Family

Transcription elongation factor A-like/Brain expressed X-linked

TF_A-like/BEX

8

IPR021157

21,157

Cytochrome c1, transmembrane anchor, C-terminal

Cyt_c1_TM_anchor_C

Homologous_superfamily

5,066

false

This entry represents the transmembrane anchor of the cytochrome c1 subunit from the cytochrome bc1 complex. This region contains a single transmembrane helix. Cytochrome bc1 complex (ubiquinol:ferricytochrome c oxidoreductase) is found in mitochondria, photosynthetic bacteria and other prokaryotes. It is minimally com...

[]

0

[ "SSF" ]

[ "SSF81496" ]

[ "" ]

[ 5066 ]

1

[ "EC", "METACYC", "METACYC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "7.1.1.8", "PWY-3781", "PWY-6692", "PWY-7279", "R-BTA-611105", "R-BTA-9865881", "R-DDI-611105", "R-HSA-1268020", "R-HSA-611105", "R-HSA-9865881", "R-MMU-611105", "R-MMU-9865881", "R-SCE-611105", "R-SCE-9865878", "R-SPO-611105" ]

[ "EC:7.1.1.8", "METACYC:PWY-3781", "METACYC:PWY-6692", "METACYC:PWY-7279", "REACTOME:R-BTA-611105", "REACTOME:R-BTA-9865881", "REACTOME:R-DDI-611105", "REACTOME:R-HSA-1268020", "REACTOME:R-HSA-611105", "REACTOME:R-HSA-9865881", "REACTOME:R-MMU-611105", "REACTOME:R-MMU-9865881", "REACTOME:R-SC...

15

[ "1bcc", "1be3", "1bgy", "1ezv", "1kb9", "1kyo", "1l0l", "1l0n", "1ntk", "1ntm", "1ntz", "1nu1", "1p84", "1pp9", "1ppj", "1qcr", "1sqb", "1sqp", "1sqq", "1sqv", "1sqx", "2a06", "2bcc", "2fyu", "2ibz", "2ybb", "3bcc", "3cwb", "3cx5", "3cxh", "3h1h", "3h1i"...

181

[ "PUB00005442" ]

[ "7631417" ]

[ "Cytochrome f revealed." ]

[ 1995 ]

1

[]

0

null

[ "Eukaryota", "Pseudomonadati", "metagenomes" ]

[ 4551, 501, 14 ]

3

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 5, 1, 1, 2, 2, 1, 1, 5, 3, 1, 1, 9 ]

12

true

Homologous_superfamily

Cytochrome c1, transmembrane anchor, C-terminal

Cyt_c1_TM_anchor_C

2

IPR021158

21,158

Peptidase M10A, cysteine switch, zinc binding site

Pept_M10A_Zn_BS

Binding_site

12,911

false

Over 70 metallopeptidase families have been identified to date. In these enzymes a divalent cation, which is usually zinc but may be cobalt, manganese or copper, activates the water molecule. The metal ion is held in place by amino acid ligands, usually three in number. In some families of co-catalytic metallopeptidase...

[ "GO:0004222", "GO:0008270", "GO:0006508", "GO:0031012" ]

[ "metalloendopeptidase activity", "zinc ion binding", "proteolysis", "extracellular matrix" ]

[ "molecular_function", "molecular_function", "biological_process", "cellular_component" ]

4

[ "PROSITE" ]

[ "PS00546" ]

[ "CYSTEINE_SWITCH" ]

[ 12911 ]

1

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", ...

[ "3.4.24", "R-BTA-1433557", "R-BTA-1442490", "R-BTA-1474228", "R-BTA-1592389", "R-BTA-3928665", "R-BTA-6798695", "R-BTA-9009391", "R-CEL-1442490", "R-CEL-1474228", "R-CEL-1592389", "R-CEL-210991", "R-CEL-2168880", "R-CEL-2179392", "R-CEL-3928665", "R-CEL-6798695", "R-CFA-1442490", "...

[ "EC:3.4.24", "REACTOME:R-BTA-1433557", "REACTOME:R-BTA-1442490", "REACTOME:R-BTA-1474228", "REACTOME:R-BTA-1592389", "REACTOME:R-BTA-3928665", "REACTOME:R-BTA-6798695", "REACTOME:R-BTA-9009391", "REACTOME:R-CEL-1442490", "REACTOME:R-CEL-1474228", "REACTOME:R-CEL-1592389", "REACTOME:R-CEL-21099...

68

[ "1ck7", "1eak", "1gxd", "1l6j", "1slm", "1su3", "2mze", "2mzh", "2mzi", "5th6", "5th9", "5ue2", "5ue3", "5ue4", "5ue5", "8k5v", "8k5w", "8k5x", "8k5y", "9csx" ]

20

[ "PUB00001191", "PUB00002456", "PUB00002514", "PUB00002651", "PUB00003579" ]

[ "2167841", "2841336", "2551898", "1988438", "7674922" ]

[ "Early expression of a collagenase-like hatching enzyme gene in the sea urchin embryo.", "Structure-function relationships in the collagenase family member transin.", "SV40-transformed human lung fibroblasts secrete a 92-kDa type IV collagenase which is identical to that secreted by normal human macrophages.", ...

[ 1990, 1988, 1989, 1991, 1995 ]

5

[]

0

null

[ "Bacteria", "Eukaryota", "Halosegnis marinus", "Viruses", "ecological metagenomes" ]

[ 115, 12785, 1, 5, 5 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 11, 1, 13, 48, 46, 38 ]

6

true

Binding_site

Peptidase M10A, cysteine switch, zinc binding site

Pept_M10A_Zn_BS

9

IPR021162

21,162

Histone H3-K79 methyltransferase, fungi

Dot1

Family

1,128

false

This entry represents a group of fungal histone H3-K79 methyltransferase, including Dot1 from Saccharomyces cerevisiae. Dot1 specifically methylates histone H3 to form H3K79me. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment ...

[ "GO:0031151", "GO:0042393", "GO:0000077", "GO:0006281", "GO:0031509", "GO:0000786" ]

[ "histone H3K79 methyltransferase activity", "histone binding", "DNA damage checkpoint signaling", "DNA repair", "subtelomeric heterochromatin formation", "nucleosome" ]

[ "molecular_function", "molecular_function", "biological_process", "biological_process", "biological_process", "cellular_component" ]

6

[ "PIRSF" ]

[ "PIRSF017570" ]

[ "Histone_H3-K79_MeTrfase" ]

[ 1128 ]

1

[ "EC", "REACTOME" ]

[ "2.1.1.360", "R-SCE-3214841" ]

[ "EC:2.1.1.360", "REACTOME:R-SCE-3214841" ]

2

[ "1u2z", "7k6p", "7k6q" ]

3

[ "PUB00058033", "PUB00058037" ]

[ "11029058", "16166626" ]

[ "Role for the silencing protein Dot1 in meiotic checkpoint control.", "Role of Dot1-dependent histone H3 methylation in G1 and S phase DNA damage checkpoint functions of Rad9." ]

[ 2000, 2005 ]

2

[ "IPR030445" ]

[]

1

0

1

[ "Fungi" ]

[ 1128 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)" ]

[ 1, 1 ]

2

true

Family

Histone H3-K79 methyltransferase, fungi

Dot1

1

IPR021163

21,163

Ferredoxin-NADP+ reductase, adrenodoxin-type

Ferredox_Rdtase_adrenod

Family

10,539

false

This family represents a group of adrenodoxin-type ferredoxin reductases, including human Fdxr (NADPH:adrenodoxin oxidoreductase, mitochondrial) [ ] and Mycobacterium FprA [ ].

[ "GO:0016491" ]

[ "oxidoreductase activity" ]

[ "molecular_function" ]

1

[ "PIRSF" ]

[ "PIRSF000362" ]

[ "FNR" ]

[ 10539 ]

1

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "1.18.1.6", "R-DDI-2395516", "R-DME-2395516", "R-HSA-196108", "R-HSA-211976", "R-HSA-2395516", "R-HSA-5579026", "R-MMU-196108", "R-MMU-211976", "R-MMU-2395516", "R-RNO-196108", "R-RNO-211976", "R-RNO-2395516", "R-SCE-2395516", "R-SPO-2395516" ]

[ "EC:1.18.1.6", "REACTOME:R-DDI-2395516", "REACTOME:R-DME-2395516", "REACTOME:R-HSA-196108", "REACTOME:R-HSA-211976", "REACTOME:R-HSA-2395516", "REACTOME:R-HSA-5579026", "REACTOME:R-MMU-196108", "REACTOME:R-MMU-211976", "REACTOME:R-MMU-2395516", "REACTOME:R-RNO-196108", "REACTOME:R-RNO-211976",...

15

[ "1cjc", "1e1k", "1e1l", "1e1m", "1e1n", "1e6e", "1lqt", "1lqu", "2c7g" ]

9

[ "PUB00056867", "PUB00073555" ]

[ "2236061", "12071965" ]

[ "Cloning and sequence of the human adrenodoxin reductase gene.", "Mycobacterium tuberculosis FprA, a novel bacterial NADPH-ferredoxin reductase." ]

[ 1990, 2002 ]

2

[ "IPR055275" ]

[]

1

0

1

[ "Bacteria", "Eukaryota", "ecological metagenomes" ]

[ 6133, 4284, 122 ]

3

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 5, 1, 1, 4, 10, 4, 1, 2, 4, 1, 1, 8 ]

12

true

Family

Ferredoxin-NADP+ reductase, adrenodoxin-type

Ferredox_Rdtase_adrenod

9

IPR021164

21,164

Tyrosine hydroxylase, conserved site

Tyrosine_hydroxylase_CS

Conserved_site

1,023

false

This domain family is found in eukaryotes, and is approximately 30 amino acids in length. There is a single completely conserved residue G that may be functionally important. Tyrosine hydroxylase converts L-tyrosine to L-DOPA in the catecholamine synthesis pathway.

[ "GO:0004511" ]

[ "tyrosine 3-monooxygenase activity" ]

[ "molecular_function" ]

1

[ "PFAM" ]

[ "PF12549" ]

[ "TOH_N" ]

[ 1023 ]

1

[ "EC", "METACYC", "METACYC", "METACYC", "METACYC", "REACTOME", "REACTOME", "REACTOME" ]

[ "1.14.16.2", "PWY-3581", "PWY-5049", "PWY-5394", "PWY-6133", "R-HSA-209905", "R-MMU-209905", "R-RNO-209905" ]

[ "EC:1.14.16.2", "METACYC:PWY-3581", "METACYC:PWY-5049", "METACYC:PWY-5394", "METACYC:PWY-6133", "REACTOME:R-HSA-209905", "REACTOME:R-MMU-209905", "REACTOME:R-RNO-209905" ]

8

[ "4j6s" ]

1

[]

0

[]

0

null

[ "Opisthokonta" ]

[ 1023 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 16, 5, 9 ]

4

true

Conserved_site

Tyrosine hydroxylase, conserved site

Tyrosine_hydroxylase_CS

2

IPR021165

21,165

Saposin, chordata

Saposin_chordata

Family

1,412

false

Sphingolipids are bioactive compounds found in lower and higher eukaryotes. They are involved in the regulation of various cellular functions, such as growth, differentiation and apoptosis, and are believed to be essential in a healthy diet. Sphigolipids are degraded in the lysosome, and the products from their hydroly...

[ "GO:0006665", "GO:0005764" ]

[ "sphingolipid metabolic process", "lysosome" ]

[ "biological_process", "cellular_component" ]

2

[ "PIRSF" ]

[ "PIRSF002431" ]

[ "Saposin" ]

[ 1412 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-114608", "R-HSA-375276", "R-HSA-418594", "R-HSA-6798695", "R-HSA-9840310", "R-MMU-114608", "R-MMU-375276", "R-MMU-418594", "R-MMU-6798695", "R-MMU-9840310", "R-RNO-114608", "R-RNO-375276", "R-RNO-418594", "R-RNO-6798695", "R-RNO-9840310" ]

[ "REACTOME:R-HSA-114608", "REACTOME:R-HSA-375276", "REACTOME:R-HSA-418594", "REACTOME:R-HSA-6798695", "REACTOME:R-HSA-9840310", "REACTOME:R-MMU-114608", "REACTOME:R-MMU-375276", "REACTOME:R-MMU-418594", "REACTOME:R-MMU-6798695", "REACTOME:R-MMU-9840310", "REACTOME:R-RNO-114608", "REACTOME:R-RNO...

15

[]

0

[ "PUB00011688", "PUB00011689" ]

[ "2515150", "2019586" ]

[ "Molecular cloning of a human co-beta-glucosidase cDNA: evidence that four sphingolipid hydrolase activator proteins are encoded by single genes in humans and rats.", "Sulfatide activator protein. Alternative splicing that generates three mRNAs and a newly found mutation responsible for a clinical disease." ]

[ 1989, 1991 ]

2

[ "IPR008373" ]

[]

1

0

1

[ "Gnathostomata", "Kangiella spongicola" ]

[ 1411, 1 ]

2

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 6, 25, 14 ]

4

true

Family

Saposin, chordata

Saposin_chordata

1

IPR021168

21,168

Bifunctional polymyxin resistance protein, ArnA

Bifun_polymyxin_resist_ArnA

Family

1,988

false

Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto-arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido-arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A an...

[ "GO:0016742" ]

[ "hydroxymethyl-, formyl- and related transferase activity" ]

[ "molecular_function" ]

1

[ "HAMAP", "PIRSF" ]

[ "MF_01166", "PIRSF036506" ]

[ "ArnA", "Bifun_polymyxin_resist_ArnA" ]

[ 1978, 1978 ]

2

[ "EC", "EC" ]

[ "1.1.1.305", "2.1.2.13" ]

[ "EC:1.1.1.305", "EC:2.1.2.13" ]

2

[ "1z7e", "4wkg", "8gjh" ]

3

[]

0

[]

0

null

[ "Bacteria", "Beauveria bassiana D1-5" ]

[ 1987, 1 ]

2

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Bifunctional polymyxin resistance protein, ArnA

Bifun_polymyxin_resist_ArnA

9

IPR021169

21,169

Histone H3-K79 methyltransferase, metazoa

DOT1L/grappa

Family

655

false

This entry represents a group of histone H3-K79 methyltransferases from insects and vertebrates. They are yeast Dot1 homologues that possess intrinsic H3-K79-specific histone methyltransferase (HMTase) activity [ ]. In Drosophila, it is also known as protein grappa (gpp), which is required for Polycomb Group (PcG) and ...

[ "GO:0031151", "GO:0031507", "GO:0005634" ]

[ "histone H3K79 methyltransferase activity", "heterochromatin formation", "nucleus" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PIRSF" ]

[ "PIRSF037123" ]

[ "Histone_H3-K79_MeTrfase_met" ]

[ 655 ]

1

[ "REACTOME" ]

[ "R-HSA-3214841" ]

[ "REACTOME:R-HSA-3214841" ]

1

[]

0

[ "PUB00033352", "PUB00058038" ]

[ "12123582", "15371351" ]

[ "Methylation of H3-lysine 79 is mediated by a new family of HMTases without a SET domain.", "Characterization of the grappa gene, the Drosophila histone H3 lysine 79 methyltransferase." ]

[ 2002, 2005 ]

2

[ "IPR030445" ]

[]

1

0

1

[ "Bilateria" ]

[ 655 ]

1

[ "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 4, 4, 4 ]

4

true

Family

Histone H3-K79 methyltransferase, metazoa

DOT1L/grappa

9

IPR021170

21,170

DnaJ homologue subfamily C member 10

ERdj5

Family

649

false

This group represents ER-resident disulfide reductase protein ERdj5, also known as DnaJ homologue subfamily C member 10. It is a endoplasmic reticulum co-chaperone, involved both in the correct folding of proteins that form obligatory non-native disulfides and degradation of misfolded proteins [ , , , ].

[ "GO:0015036", "GO:0034975", "GO:0005783" ]

[ "disulfide oxidoreductase activity", "protein folding in endoplasmic reticulum", "endoplasmic reticulum" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PIRSF" ]

[ "PIRSF037293" ]

[ "DnaJ_homolog_subfam-C" ]

[ 649 ]

1

[ "EC" ]

[ "1.8.4.2" ]

[ "EC:1.8.4.2" ]

1

[ "3apo", "5ayk", "5ayl" ]

3

[ "PUB00073623", "PUB00073624", "PUB00073625", "PUB00073626" ]

[ "12411443", "18400946", "23769672", "25055872" ]

[ "ERdj5, an endoplasmic reticulum (ER)-resident protein containing DnaJ and thioredoxin domains, is expressed in secretory cells or following ER stress.", "ERdj4 and ERdj5 are required for endoplasmic reticulum-associated protein degradation of misfolded surfactant protein C.", "ERdj5 is the ER reductase that ca...

[ 2003, 2008, 2013, 2014 ]

4

[]

0

null

[ "Bilateria" ]

[ 649 ]

1

[ "Caenorhabditis elegans", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 3, 1, 2 ]

4

true

Family

DnaJ homologue subfamily C member 10

ERdj5

9

IPR021171

21,171

Core histone macro-H2A

Core_histone_macro-H2A

Family

1,608

false

This group represents a core histone macro-H2A. MacroH2A is a variant of the major-type core histone H2A which contains an N-terminal H2A domain and a C-terminal nonhistone macro domain. Histone macroH2A is enriched on the inactive X chromosome of mammalian female cells [ ]. It does not bind poly ADP-ribose, but does b...

[ "GO:0003677", "GO:0030527", "GO:0006334", "GO:0000786" ]

[ "DNA binding", "structural constituent of chromatin", "nucleosome assembly", "nucleosome" ]

[ "molecular_function", "molecular_function", "biological_process", "cellular_component" ]

4

[ "PIRSF" ]

[ "PIRSF037942" ]

[ "Core_histone_macro-H2A" ]

[ 1608 ]

1

[]

0

[]

0

[ "PUB00033734", "PUB00037830", "PUB00086219" ]

[ "15965484", "16107708", "11433014" ]

[ "Splicing regulates NAD metabolite binding to histone macroH2A.", "Structural characterization of the histone variant macroH2A.", "Histone variant macroH2A contains two distinct macrochromatin domains capable of directing macroH2A to the inactive X chromosome." ]

[ 2005, 2005, 2001 ]

3

[ "IPR002119" ]

[]

1

0

1

[ "Gnathostomata" ]

[ 1608 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 6, 2, 4, 5 ]

4

true

Family

Core histone macro-H2A

Core_histone_macro-H2A

9

IPR021172

21,172

Uncharacterised conserved protein, RNA methylase-related

UCP006607_RNA_methylase-rel

Family

70

false

Members of this group are related to ribosomal protein L11 methyltransferase ( ) and, therefore, are predicted to be RNA methylases.

[]

0

[ "PIRSF" ]

[ "PIRSF006607" ]

[ "RNAmts_UCP006607" ]

[ 70 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Methanomada group" ]

[ 70 ]

1

[]

0

true

Family

Uncharacterised conserved protein, RNA methylase-related

UCP006607_RNA_methylase-rel

4

IPR021173

21,173

Dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase

Algn-8

Family

6

false

This entry represents a group of proteins from Caenorhabditis, including Dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase from Caenorhabditis elegans (Algn-8), which operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-gly...

[]

0

[ "PIRSF" ]

[ "PIRSF037345" ]

[ "Dolichyl-P-Glc/endonucV" ]

[ 6 ]

1

[ "REACTOME" ]

[ "R-CEL-446193" ]

[ "REACTOME:R-CEL-446193" ]

1

[]

0

[]

0

[]

0

null

[ "Caenorhabditis" ]

[ 6 ]

1

[ "Caenorhabditis elegans" ]

[ 1 ]

1

true

Family

Dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase

Algn-8

3

IPR021174

21,174

Uncharacterised conserved protein UCP037139

UCP037139

Family

447

false

There are currently no experimental data for members of this group or their homologues, nor do they exhibit features indicative of any function.

[]

0

[ "PIRSF" ]

[ "PIRSF037139" ]

[ "UCP037139" ]

[ 447 ]

1

[]

0

[]

0

[ "PUB00160784" ]

[ "38748582" ]

[ "YdbH and YnbE form an intermembrane bridge to maintain lipid homeostasis in the outer membrane of Escherichia coli." ]

[ 2024 ]

1

[ "IPR058248" ]

[]

1

0

1

[ "Alphaproteobacteria" ]

[ 447 ]

1

[]

0

true

Family

Uncharacterised conserved protein UCP037139

UCP037139

5

IPR021175

21,175

Bifunctional inorganic polyphosphate/ATP-NAD kinase, predicted

Bifunctional_PpnK_predicted

Family

67

false

This group represents a bifunctional inorganic polyphosphate/ATP-NAD kinase from archaea. The enzyme from Methanocaldococcus jannaschii has been characterised and is involved in the NAD(H)/NADP(H) intracellular balance, producing the physiologically, required amount of NADP but not an excess. The enzyme has two domains...

[ "GO:0006553" ]

[ "lysine metabolic process" ]

[ "biological_process" ]

1

[ "NCBIFAM", "PIRSF" ]

[ "NF010678", "PIRSF036641" ]

[ "PRK14076.1", "Bifunctional_PpnK_predicted" ]

[ 67, 55 ]

2

[]

0

[]

0

[ "PUB00085128" ]

[ "16192277" ]

[ "MJ0917 in archaeon Methanococcus jannaschii is a novel NADP phosphatase/NAD kinase." ]

[ 2005 ]

1

[ "IPR002504" ]

[]

1

0

1

[ "Methanomada group", "bioreactor metagenome" ]

[ 66, 1 ]

2

[]

0

true

Family

Bifunctional inorganic polyphosphate/ATP-NAD kinase, predicted

Bifunctional_PpnK_predicted

4

IPR021176

21,176

Competence-induced protein CoiA

Competence-induced_CoiA

Family

2,048

false

This group represents competence protein CoiA found in bacteria belonging to the Bacilli class. It is required for optimal transformation [ ]. CoiA is a transient protein expressed specifically during competence and required for genetic transformation, but not for DNA uptake [ , ].

[]

0

[ "PIRSF" ]

[ "PIRSF007487" ]

[ "Competence-induced_CoiA_bac" ]

[ 2048 ]

1

[]

0

[]

0

[ "PUB00081394", "PUB00081440", "PUB00081441" ]

[ "17630974", "17233830", "16816189" ]

[ "Multiple interactions among the competence proteins of Bacillus subtilis.", "Transformation in Streptococcus pneumoniae: formation of eclipse complex in a coiA mutant implicates CoiA in genetic recombination.", "An unstable competence-induced protein, CoiA, promotes processing of donor DNA after uptake during ...

[ 2007, 2007, 2006 ]

3

[]

0

null

[ "Bacteria", "Siphoviridae sp. ctVsq1" ]

[ 2047, 1 ]

2

[]

0

true

Family

Competence-induced protein CoiA

Competence-induced_CoiA

5

IPR021179

21,179

Mercury(II) reductase

Mercury_reductase_MerA

Family

3,251

false

This entry represents the mercuric reductase found in the mer operon for the detoxification of mercury compounds. MerA is a FAD-containing flavoprotein which reduces Hg(II) to Hg(0) utilizing NADPH [ ].

[ "GO:0016152", "GO:0016491", "GO:0045340", "GO:0050660", "GO:0050661", "GO:0050787" ]

[ "mercury (II) reductase (NADP+) activity", "oxidoreductase activity", "mercury ion binding", "flavin adenine dinucleotide binding", "NADP binding", "detoxification of mercury ion" ]

[ "molecular_function", "molecular_function", "molecular_function", "molecular_function", "molecular_function", "biological_process" ]

6

[ "NCBIFAM" ]

[ "TIGR02053" ]

[ "MerA" ]

[ 3251 ]

1

[ "EC", "GP" ]

[ "1.16.1.1", "GenProp0151" ]

[ "EC:1.16.1.1", "GP:GenProp0151" ]

2

[ "1zk7", "1zx9", "4k7z", "4k8d", "4ywo", "5x1y" ]

6

[ "PUB00015465" ]

[ "8467420" ]

[ "Purification and properties of mercuric reductase from Yersinia enterocolitica 138A14." ]

[ 1993 ]

1

[ "IPR001100" ]

[]

1

0

1

[ "Archaea", "Bacteria", "Eukaryota", "plasmids", "unclassified sequences" ]

[ 178, 2998, 13, 3, 59 ]

5

[]

0

true

Family

Mercury(II) reductase

Mercury_reductase_MerA

7

IPR021180

21,180

Protein lysine methyltranseferase, predicted

Protein_Lys_MeTrfase_predicted

Family

24

false

This entry represents a group of uncharacterised bacterial proteins, predicted to be lysine methyltranseferases.

[]

0

[ "PIRSF" ]

[ "PIRSF029047" ]

[ "Protein_Lys_MeTrfase_predicted" ]

[ 24 ]

1

[]

0

[]

0

[]

0

[ "IPR026170" ]

[]

1

0

1

[ "Chlamydiia" ]

[ 24 ]

1

[]

0

true

Family

Protein lysine methyltranseferase, predicted

Protein_Lys_MeTrfase_predicted

9

IPR021181

21,181

Mitochondrial Rho GTPase

Miro

Family

6,875

false

Mitochondrial Rho (Miro) proteins are aberrant members of the small GTPase superfamily found in most eukaryotes. Miro contains a transmembrane region located at the C terminus anchors the protein to the outer membrane of mitochondria, the GTPase domains and EF-hands located in the cytoplasm. Miro and its cytoplasmic bi...

[ "GO:0003924", "GO:0005509", "GO:0005525", "GO:0007005", "GO:0005741" ]

[ "GTPase activity", "calcium ion binding", "GTP binding", "mitochondrion organization", "mitochondrial outer membrane" ]

[ "molecular_function", "molecular_function", "molecular_function", "biological_process", "cellular_component" ]

5

[ "PIRSF" ]

[ "PIRSF037488" ]

[ "Mt_Rho_GTPase" ]

[ 6875 ]

1

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", ...

[ "3.6.5.-", "R-BTA-5689880", "R-BTA-9013419", "R-BTA-9013425", "R-CEL-5689880", "R-CEL-9013419", "R-CEL-9013425", "R-DDI-9013419", "R-DDI-9013425", "R-DME-5689880", "R-DME-9013419", "R-DME-9013425", "R-DRE-5689880", "R-DRE-9013419", "R-DRE-9013425", "R-HSA-5689880", "R-HSA-9013419", ...

[ "EC:3.6.5.-", "REACTOME:R-BTA-5689880", "REACTOME:R-BTA-9013419", "REACTOME:R-BTA-9013425", "REACTOME:R-CEL-5689880", "REACTOME:R-CEL-9013419", "REACTOME:R-CEL-9013425", "REACTOME:R-DDI-9013419", "REACTOME:R-DDI-9013425", "REACTOME:R-DME-5689880", "REACTOME:R-DME-9013419", "REACTOME:R-DME-9013...

28

[ "9e2p" ]

1

[ "PUB00085980", "PUB00085981", "PUB00085982", "PUB00085983", "PUB00085984" ]

[ "27064409", "24711517", "27386195", "21825164", "28122638" ]

[ "C. elegans miro-1 Mutation Reduces the Amount of Mitochondria and Extends Life Span.", "Miro1: new wheels for transferring mitochondria.", "Regulation of mitochondrial trafficking, function and quality control by the mitochondrial GTPases Miro1 and Miro2.", "The conserved GTPase Gem1 regulates endoplasmic re...

[ 2016, 2014, 2015, 2011, 2017 ]

5

[ "IPR001806" ]

[]

1

0

1

[ "Eukaryota" ]

[ 6875 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 12, 1, 12, 4, 5, 2, 1, 8, 11, 1, 1, 15 ]

12

true

Family

Mitochondrial Rho GTPase

Miro

9

IPR021182

21,182

Protein SOSEKI, magnoliopsida

SOK_magnoliopsida

Family

2,624

false

This entry represents proteins SOSEKI 1-5 (SOK1-5) from Arabidopsis thaliana. SOSEKI proteins (SOK1-5) integrate apical-basal and radial organismal axes to localize to polar cell edges and contain a DIX oligomerization domain that resembles that in the animal Dishevelled polarity regulator [ , ]. SOK2 is also known as ...

[]

0

[ "PIRSF" ]

[ "PIRSF031043" ]

[ "UCP031043" ]

[ 2624 ]

1

[]

0

[]

0

[ "PUB00073664", "PUB00096645", "PUB00096646", "PUB00096647" ]

[ "15186749", "18156133", "32004461", "30737509" ]

[ "A cluster of Arabidopsis genes with a coordinate response to an environmental stimulus.", "The FLX gene of Arabidopsis is required for FRI-dependent activation of FLC expression.", "DIX Domain Polymerization Drives Assembly of Plant Cell Polarity Complexes.", "A SOSEKI-based coordinate system interprets glob...

[ 2004, 2008, 2020, 2019 ]

4

[ "IPR010369" ]

[]

1

0

1

[ "Spermatophyta" ]

[ 2624 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 27, 19, 32 ]

3

true

Family

Protein SOSEKI, magnoliopsida

SOK_magnoliopsida

5

IPR021183

21,183

N-terminal acetyltransferase A, auxiliary subunit

NatA_aux_su

Family

7,445

false

This entry represents N-terminal acetyltransferase A (NatA) auxiliary subunit, which is a non-catalytic component of the NatA N-terminal acetyltransferase that catalyses acetylation of proteins beginning with Met-Ser, Met-Gly and Met-Ala. N-terminal acetylation plays a role in normal eukaryotic translation and processi...

[]

0

[ "PFAM", "PIRSF" ]

[ "PF12569", "PIRSF000422" ]

[ "NatA_aux_su", "N-terminal-AcTrfase-A_aux_su" ]

[ 7445, 5600 ]

2

[ "GP" ]

[ "GenProp1491" ]

[ "GP:GenProp1491" ]

1

[ "4hnw", "4hnx", "4hny", "4kvm", "4kvo", "4xnh", "4xpd", "4y49", "5nnp", "5nnr", "6c95", "6c9m", "6hd5", "6hd7", "6o07", "6ppl", "6pw9", "9f1b", "9f1c", "9f1d", "9fpz", "9fq0", "9qqb" ]

23

[ "PUB00053448", "PUB00053449" ]

[ "1600941", "14517307" ]

[ "ARD1 and NAT1 proteins form a complex that has N-terminal acetyltransferase activity.", "The yeast N(alpha)-acetyltransferase NatA is quantitatively anchored to the ribosome and interacts with nascent polypeptides." ]

[ 1992, 2003 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "marine sediment metagenome" ]

[ 40, 7404, 1 ]

3

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 5, 1, 3, 1, 13, 8, 1, 7, 6, 1, 2, 28 ]

12

true

Family

N-terminal acetyltransferase A, auxiliary subunit

NatA_aux_su

4

IPR021184

21,184

Tumour necrosis factor, conserved site

TNF_CS

Conserved_site

4,833

false

This entry represents α conserved site located in a β-strand in the central section of the protein which is conserved across all members of the Tumor Necrosis Factor family. Cytokines can be grouped into a family on the basis of sequence, functional and structural similarities [ , , ]. Tumor necrosis factor (TNF) (also...

[]

0

[ "PROSITE" ]

[ "PS00251" ]

[ "THD_1" ]

[ 4833 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-5668541", "R-BTA-5669034", "R-BTA-5676594", "R-CFA-198933", "R-CFA-5357786", "R-CFA-5357905", "R-CFA-5357956", "R-CFA-5626978", "R-CFA-5668541", "R-CFA-5669034", "R-CFA-5676594", "R-CFA-75893", "R-DME-450520", "R-GGA-198933", "R-GGA-5668541", "R-GGA-5676594", "R-HSA-140534", ...

[ "REACTOME:R-BTA-5668541", "REACTOME:R-BTA-5669034", "REACTOME:R-BTA-5676594", "REACTOME:R-CFA-198933", "REACTOME:R-CFA-5357786", "REACTOME:R-CFA-5357905", "REACTOME:R-CFA-5357956", "REACTOME:R-CFA-5626978", "REACTOME:R-CFA-5668541", "REACTOME:R-CFA-5669034", "REACTOME:R-CFA-5676594", "REACTOME...

74

[ "1a8m", "1aly", "1d0g", "1d2q", "1d4v", "1dg6", "1du3", "1i9r", "1tnf", "1tnr", "1u5x", "1u5y", "1u5z", "1xu1", "1xu2", "2az5", "2e7a", "2hev", "2hew", "2hey", "2tnf", "2tun", "2x29", "2zjc", "2zpx", "3alq", "3it8", "3k48", "3l9j", "3lkj", "3qd6", "3wd5"...

93

[ "PUB00000299", "PUB00000886", "PUB00000899", "PUB00001264", "PUB00002011", "PUB00002042", "PUB00002689", "PUB00004130", "PUB00006091", "PUB00006095", "PUB00006098", "PUB00006101", "PUB00015257" ]

[ "3061461", "7916655", "7505205", "8076595", "8777713", "8095800", "1850405", "1377364", "2989794", "3349526", "2777790", "2268312", "15335677" ]

[ "The history, properties, and biological effects of cachectin.", "Lymphotoxin beta, a novel member of the TNF family that forms a heteromeric complex with lymphotoxin on the cell surface.", "Molecular cloning and expression of the Fas ligand, a novel member of the tumor necrosis factor family.", "Molecular ch...

[ 1988, 1993, 1993, 1994, 1995, 1993, 1991, 1992, 1985, 1988, 1989, 1990, 1993 ]

13

[]

0

null

[ "Bacteria", "Eukaryota", "Sea otter poxvirus", "marine sediment metagenome" ]

[ 53, 4778, 1, 1 ]

4

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 6, 2, 48, 39, 30 ]

5

true

Conserved_site

Tumour necrosis factor, conserved site

TNF_CS

2

IPR021185

21,185

Tumour necrosis factor family protein, CD30 ligand type

TNF_CD30_ligand_type

Family

102

false

Cytokines can be grouped into a family on the basis of sequence, functional and structural similarities [ , , ]. Tumor necrosis factor (TNF) (also known as TNF-alpha or cachectin) is a monocyte-derived cytotoxin that has been implicated in tumour regression, septic shock and cachexia [ , ]. The protein is synthesised a...

[]

0

[ "PIRSF" ]

[ "PIRSF019548" ]

[ "TNF_CD30_ligand_type" ]

[ 102 ]

1

[ "REACTOME", "REACTOME" ]

[ "R-HSA-5669034", "R-MMU-5669034" ]

[ "REACTOME:R-HSA-5669034", "REACTOME:R-MMU-5669034" ]

2

[]

0

[ "PUB00000299", "PUB00000886", "PUB00000899", "PUB00001264", "PUB00002011", "PUB00002042", "PUB00002689", "PUB00004130", "PUB00006091", "PUB00006095", "PUB00006098", "PUB00006101", "PUB00015257", "PUB00053450" ]

[ "3061461", "7916655", "7505205", "8076595", "8777713", "8095800", "1850405", "1377364", "2989794", "3349526", "2777790", "2268312", "15335677", "8391931" ]

[ "The history, properties, and biological effects of cachectin.", "Lymphotoxin beta, a novel member of the TNF family that forms a heteromeric complex with lymphotoxin on the cell surface.", "Molecular cloning and expression of the Fas ligand, a novel member of the tumor necrosis factor family.", "Molecular ch...

[ 1988, 1993, 1993, 1994, 1995, 1993, 1991, 1992, 1985, 1988, 1989, 1990, 1993, 1993 ]

14

[]

0

null

[ "Amniota" ]

[ 102 ]

1

[ "Homo sapiens", "Mus musculus" ]

[ 2, 3 ]

2

true

Family

Tumour necrosis factor family protein, CD30 ligand type

TNF_CD30_ligand_type

6

IPR021187

21,187

Band 4.1 protein, FERM domain, F1 sub-domain

EPB4.1_FERM_F1

Domain

2,531

false

Protein 4.1 (EPB4.1) is a major structural element of the erythrocyte membrane skeleton. It plays a key role in regulating physical properties of the membrane, such as mechanical stability and de-formability, by stabilising spectrin-actin interactions [ , , ]. It is required for dynein-dynactin complex and NUMA1 recrui...

[]

0

[ "CDD" ]

[ "cd17105" ]

[ "FERM_F1_EPB41" ]

[ 2531 ]

1

[ "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-6794361", "R-HSA-6794361", "R-MMU-6794361" ]

[ "REACTOME:R-BTA-6794361", "REACTOME:R-HSA-6794361", "REACTOME:R-MMU-6794361" ]

3

[ "1gg3", "3qij" ]

2

[ "PUB00025237", "PUB00033371", "PUB00053451", "PUB00055449", "PUB00095087" ]

[ "11017195", "11003675", "1647028", "4326772", "23870127" ]

[ "Protein 4.1R core domain structure and insights into regulation of cytoskeletal organization.", "Protein 4.1 R-135 interacts with a novel centrosomal protein (CPAP) which is associated with the gamma-tubulin complex.", "Phosphorylation of protein 4.1 on tyrosine-418 modulates its function in vitro.", "Electr...

[ 2000, 2000, 1991, 1971, 2013 ]

5

[ "IPR018979" ]

[]

1

0

1

[ "Gnathostomata" ]

[ 2531 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 21, 9, 9 ]

4

true

Domain

Band 4.1 protein, FERM domain, F1 sub-domain

EPB4.1_FERM_F1

3

IPR021188

21,188

N6 adenine-specific DNA methyltransferase, TaqI class

N6_DNA_MeTrfase_TaqI

Family

33

false

In prokaryotes, the major role of DNA methylation is to protect host DNA against degradation by restriction enzymes. There are 2 major classes of DNA methyltransferase that differ in the nature of the modifications they effect. The members of one class (C-MTases) methylate a ring carbon and form C5-methylcytosine (see ...

[]

0

[ "PIRSF" ]

[ "PIRSF037236" ]

[ "Ade-sp_methyltransferase_TaqI" ]

[ 33 ]

1

[]

0

[ "1aqi", "1aqj", "1g38", "2adm", "2ibs", "2ibt", "2ih2", "2ih4", "2ih5", "2jg3", "2np6", "2np7" ]

12

[ "PUB00000092", "PUB00001770", "PUB00001857", "PUB00003225", "PUB00003245", "PUB00004831", "PUB00054009" ]

[ "7663118", "3248728", "7607512", "3323532", "2541254", "7971991", "9931007" ]

[ "Structure and function of DNA methyltransferases.", "The amino acid sequence of the eukaryotic DNA [N6-adenine]methyltransferase, M.CviBIII, has regions of similarity with the prokaryotic isoschizomer M.TaqI and other DNA [N6-adenine] methyltransferases.", "Sequence motifs characteristic for DNA [cytosine-N4] ...

[ 1995, 1988, 1995, 1987, 1989, 1994, 1999 ]

7

[]

0

null

[ "Thermus" ]

[ 33 ]

1

[]

0

true

Family

N6 adenine-specific DNA methyltransferase, TaqI class

N6_DNA_MeTrfase_TaqI

9

IPR021190

21,190

Peptidase M10A

Pept_M10A

Family

30,892

false

The MEROPS peptidase family M10, subfamily M10A, consists of extracellular metalloproteases, such as collagenase and stromelysin, that degrade the extracellular matrix and are known as matrixins or matrix metalloproteinases (MMPs). They are zinc-dependent, calcium-activated proteases synthesised as inactive precursors(...

[ "GO:0004222", "GO:0008270", "GO:0006508" ]

[ "metalloendopeptidase activity", "zinc ion binding", "proteolysis" ]

[ "molecular_function", "molecular_function", "biological_process" ]

3

[ "PIRSF", "PRINTS" ]

[ "PIRSF001191", "PR00138" ]

[ "Peptidase_M10A_matrix", "MATRIXIN" ]

[ 18720, 30671 ]

2

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", ...

[ "3.4.24", "R-BTA-1433557", "R-BTA-1442490", "R-BTA-1474228", "R-BTA-1592389", "R-BTA-3928665", "R-BTA-6798695", "R-BTA-9009391", "R-CEL-1442490", "R-CEL-1474228", "R-CEL-1592389", "R-CEL-210991", "R-CEL-2168880", "R-CEL-2179392", "R-CEL-3928665", "R-CEL-6798695", "R-CFA-1442490", "...

[ "EC:3.4.24", "REACTOME:R-BTA-1433557", "REACTOME:R-BTA-1442490", "REACTOME:R-BTA-1474228", "REACTOME:R-BTA-1592389", "REACTOME:R-BTA-3928665", "REACTOME:R-BTA-6798695", "REACTOME:R-BTA-9009391", "REACTOME:R-CEL-1442490", "REACTOME:R-CEL-1474228", "REACTOME:R-CEL-1592389", "REACTOME:R-CEL-21099...

76

[ "1a85", "1a86", "1ayk", "1b3d", "1b8y", "1biw", "1bm6", "1bqo", "1bqq", "1buv", "1bzs", "1c3i", "1c8t", "1caq", "1cge", "1cgf", "1cgl", "1ciz", "1ck7", "1cqr", "1cxv", "1d5j", "1d7x", "1d8f", "1d8m", "1eak", "1eub", "1fbl", "1fls", "1fm1", "1g05", "1g49"...

288

[ "PUB00001191", "PUB00002456", "PUB00002514", "PUB00002651", "PUB00069037", "PUB00069038" ]

[ "2167841", "2841336", "2551898", "1988438", "11544020", "19800373" ]

[ "Early expression of a collagenase-like hatching enzyme gene in the sea urchin embryo.", "Structure-function relationships in the collagenase family member transin.", "SV40-transformed human lung fibroblasts secrete a 92-kDa type IV collagenase which is identical to that secreted by normal human macrophages.", ...

[ 1990, 1988, 1989, 1991, 2001, 2010 ]

6

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "metagenomes" ]

[ 100, 1577, 29101, 68, 46 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 21, 7, 58, 10, 70, 66, 17, 66, 8 ]

9

true

Family

Peptidase M10A

Pept_M10A

8

IPR021191

21,191

Restriction endonuclease, type II, DpnII

Restrct_endonuc_II_DpnII

Family

569

false

There are four classes of restriction endonucleases: types I, II, III and IV. All types of enzymes recognise specific short DNA sequences and carry out the endonucleolytic cleavage of DNA to give specific double-stranded fragments with terminal 5'-phosphates. They differ in their recognition sequence, subunit compositi...

[ "GO:0003677", "GO:0009036", "GO:0009307" ]

[ "DNA binding", "type II site-specific deoxyribonuclease activity", "DNA restriction-modification system" ]

[ "molecular_function", "molecular_function", "biological_process" ]

3

[ "PIRSF" ]

[ "PIRSF016080" ]

[ "Restrict_endonuc_II_DpmII" ]

[ 569 ]

1

[ "EC" ]

[ "3.1.21.4" ]

[ "EC:3.1.21.4" ]

1

[]

0

[ "PUB00010050", "PUB00035691", "PUB00035692", "PUB00035693", "PUB00035694", "PUB00035705", "PUB00035707" ]

[ "11133943", "15770420", "14576294", "11827971", "11557805", "15121719", "12665693" ]

[ "Evidence for horizontal transfer of SsuDAT1I restriction-modification genes to the Streptococcus suis genome.", "Type II restriction endonucleases: structure and mechanism.", "Diversity of type II restriction endonucleases that require two DNA recognition sites.", "Evolutionary relationship between different...

[ 2001, 2005, 2003, 2002, 2001, 2004, 2003 ]

7

[]

0

null

[ "Archaea", "Bacteria", "Pseudochlorodesmis sp. HV01306a", "unclassified sequences" ]

[ 17, 548, 1, 3 ]

4

[]

0

true

Family

Restriction endonuclease, type II, DpnII

Restrct_endonuc_II_DpnII

2

IPR021192

21,192

Uncharacterised conserved protein UCP031578, VanZ/RDD-type

UCP031578_Vanz/RDD

Family

820

false

This entry represents an uncharacterised protein with VanZ and RDD domains.

[]

0

[ "PIRSF" ]

[ "PIRSF031578" ]

[ "Uncharacterised_Vanz_RDD-cont" ]

[ 820 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacillati", "unclassified sequences" ]

[ 818, 2 ]

2

[]

0

true

Family

Uncharacterised conserved protein UCP031578, VanZ/RDD-type

UCP031578_Vanz/RDD

4

IPR021193

21,193

BPI fold-containing family B member 1

Bpifb1

Family

258

false

This entry represents long palate, lung and nasal epithelium carcinoma-associated protein 1 (Lplunc1), also known as BPI fold-containing family B member 1, which belongs to the palate, lung, and nasal epithelium clone (PLUNC) family. It is a small secreted protein expressed in the oropharynx and upper airways of humans...

[ "GO:0005615" ]

[ "extracellular space" ]

[ "cellular_component" ]

1

[ "PIRSF", "PANTHER" ]

[ "PIRSF037186", "PTHR47395" ]

[ "PLUNC_long_form", "" ]

[ 164, 258 ]

2

[ "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-6803157", "R-MMU-6803157", "R-RNO-6803157" ]

[ "REACTOME:R-HSA-6803157", "REACTOME:R-MMU-6803157", "REACTOME:R-RNO-6803157" ]

3

[]

0

[ "PUB00053474", "PUB00053475" ]

[ "15028288", "14745963" ]

[ "Cloning and expression of a mouse member of the PLUNC protein family exclusively expressed in tongue epithelium.", "Identification of a novel left-right asymmetrically expressed gene in the mouse belonging to the BPI/PLUNC superfamily." ]

[ 2004, 2004 ]

2

[]

0

null

[ "Amniota" ]

[ 258 ]

1

[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 3, 1, 7 ]

3

true

Family

BPI fold-containing family B member 1

Bpifb1

6

IPR021194

21,194

Uncharacterised protein family, dehydrogenase DR0790 type, predicted

Uncharacterised_DHase_DR0790

Family

34

false

This entry represents a predicted dehydrogenase, designated as DR0790.

[]

0

[ "PIRSF" ]

[ "PIRSF026478" ]

[ "Uncharacterised_DHase_DR0790" ]

[ 34 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Deinococci" ]

[ 34 ]

1

[]

0

true

Family

Uncharacterised protein family, dehydrogenase DR0790 type, predicted

Uncharacterised_DHase_DR0790

6

IPR021195

21,195

Ubiquinol cytochrome c reductase, cytochrome c1 subunit, predicted

Ubol_Cyt_c_Rdtase_Cyt_c_su_prd

Family

442

false

This entry contains putative Ubiquinol cytochrome c reductase, cytochrome c1 subunit proteins found in some Proteobacteria and Aquificae. They are not characterised at present.

[]

0

[ "PIRSF" ]

[ "PIRSF019225" ]

[ "Ubol_Cyt_c_Rdtase_Cyt_c_su_prd" ]

[ 442 ]

1

[]

0

[]

0

[]

0

[ "IPR002326" ]

[]

1

0

1

[ "Pseudomonadati", "ecological metagenomes" ]

[ 429, 13 ]

2

[]

0

true

Family

Ubiquinol cytochrome c reductase, cytochrome c1 subunit, predicted

Ubol_Cyt_c_Rdtase_Cyt_c_su_prd

3

IPR021196

21,196

PdxT/SNO family, conserved site

PdxT/SNO_CS

Conserved_site

10,971

false

The term vitamin B6 is used to refer collectively to the compound pyridoxine and its vitameric forms, pyridoxal, pyridoxamine, and their phosphorylated derivatives. Vitamin B6 is required by all organisms and plays an essential role as a co-factor for enzymatic reactions. Plants, fungi, bacteria, archaebacteria, and pr...

[]

0

[ "PROSITE" ]

[ "PS01236" ]

[ "PDXT_SNO_1" ]

[ 10971 ]

1

[ "EC", "EC", "METACYC", "METACYC" ]

[ "3.5.1.2", "4.3.3.6", "PWY-5921", "PWY-6466" ]

[ "EC:3.5.1.2", "EC:4.3.3.6", "METACYC:PWY-5921", "METACYC:PWY-6466" ]

4

[ "1q7r", "1r9g", "2abw", "2iss", "2nv0", "2nv2", "2ywd", "2ywj", "4ads", "4wxy", "8u7j" ]

11

[ "PUB00018041", "PUB00018042", "PUB00018044", "PUB00018045" ]

[ "14764090", "14762015", "14585832", "11344146" ]

[ "Characterization of the products of the genes SNO1 and SNZ1 involved in pyridoxine synthesis in Saccharomyces cerevisiae.", "Physical and enzymological interaction of Bacillus subtilis proteins required for de novo pyridoxal 5'-phosphate biosynthesis.", "Three-dimensional structure of YaaE from Bacillus subtil...

[ 2004, 2004, 2004, 2001 ]

4

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Siphoviridae sp. ctg0K17", "unclassified sequences" ]

[ 490, 7702, 2533, 1, 245 ]

5

[ "Arabidopsis thaliana", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)", "Zea mays" ]

[ 2, 1, 2, 3, 1, 8 ]

6

true

Conserved_site

PdxT/SNO family, conserved site

PdxT/SNO_CS

9

IPR021197

21,197

Cross-wall-targeting lipoprotein motif

Cross-wall-target_lipo_motif

Conserved_site

552

false

The N-terminal YSIRK signal domain targets proteins to the cross-wall, or septum, of dividing Gram-positive bacteria. Lipoprotein signal motifs direct a characteristic N-terminal cleavage and lipid modification for membrane anchoring. This Streptococcal-only signal peptide variant appears to be a hybrid between the two...

[]

0

[ "NCBIFAM" ]

[ "TIGR03726" ]

[ "strep_RK_lipo" ]

[ 552 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Siphoviridae sp. ctHip2" ]

[ 551, 1 ]

2

[]

0

true

Conserved_site

Cross-wall-targeting lipoprotein motif

Cross-wall-target_lipo_motif

6

IPR021198

21,198

Pyridoxamine 5'-phosphate oxidase, plant

Pyridox_Oxase_pln

Family

18

false

This entry represents plant-specific pyridoxine/pyridoxamine 5'-phosphate oxidase 1 (PPOX1 or PDX3) [ ]. It is involved in the salvage pathway of pyridoxal 5'-phosphate (vitamin B6) [ ].

[ "GO:0004733", "GO:0052856", "GO:0008615" ]

[ "pyridoxamine phosphate oxidase activity", "NAD(P)HX epimerase activity", "pyridoxine biosynthetic process" ]

[ "molecular_function", "molecular_function", "biological_process" ]

3

[ "PIRSF" ]

[ "PIRSF037048" ]

[ "PyrdxN_5-P_Oxase_ross-cont_pln" ]

[ 18 ]

1

[]

0

[]

0

[ "PUB00073573", "PUB00073574", "PUB00085041" ]

[ "17224143", "17873088", "24599492" ]

[ "Identification of a pyridoxine (pyridoxamine) 5'-phosphate oxidase from Arabidopsis thaliana.", "Vitamer levels, stress response, enzyme activity, and gene regulation of Arabidopsis lines mutant in the pyridoxine/pyridoxamine 5'-phosphate oxidase (PDX3) and the pyridoxal kinase (SOS4) genes involved in the vitam...

[ 2007, 2007, 2014 ]

3

[ "IPR000659" ]

[]

1

0

1

[ "Mesangiospermae" ]

[ 18 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica" ]

[ 3, 4 ]

2

true

Family

Pyridoxamine 5'-phosphate oxidase, plant

Pyridox_Oxase_pln

8

IPR021200

21,200

Conserved hypothetical integral membrane protein, lactobacillales

CHIM_prot_lactobac

Family

133

false

This entry represents a small clade from Lactobacillales that correlates (by both gene clustering and phyletic pattern) to the three gene system that includes , and found in several Gram-positive bacteria, where (XrtG) is distantly related to exosortases. Both this narrow clade, and the larger set of full-length homolo...

[]

0

[ "NCBIFAM" ]

[ "TIGR03766" ]

[ "" ]

[ 133 ]

1

[ "GP" ]

[ "GenProp0669" ]

[ "GP:GenProp0669" ]

1

[]

0

[ "PUB00060405" ]

[ "22037399" ]

[ "Archaeosortases and exosortases are widely distributed systems linking membrane transit with posttranslational modification." ]

[ 2012 ]

1

[ "IPR060765" ]

[]

1

0

1

[ "Lactobacillales" ]

[ 133 ]

1

[]

0

true

Family

Conserved hypothetical integral membrane protein, lactobacillales

CHIM_prot_lactobac

3

IPR021201

21,201

Leader peptide, exosporium

Leader_pep_exosporium

Domain

938

false

This domain is found as a leader peptide in at least two proteins targeted to the exosporium, a structure that occurs as the outermost layer of Bacillus anthracis, Bacillus cereus, and Bacillus thuringiensis spores. The exosporium consists of a basal layer and a nap of hair-like filaments. BclA, the major protein of th...

[]

0

[ "NCBIFAM" ]

[ "TIGR03720" ]

[ "exospor_lead" ]

[ 938 ]

1

[ "GP" ]

[ "GenProp0847" ]

[ "GP:GenProp0847" ]

1

[ "1wck", "9h3d" ]

2

[ "PUB00062400" ]

[ "18761690" ]

[ "Targeting of the BclA and BclB proteins to the Bacillus anthracis spore surface." ]

[ 2008 ]

1

[]

0

null

[ "Bacillus phage Negev_SA", "Bacteria" ]

[ 1, 937 ]

2

[]

0

true

Domain

Leader peptide, exosporium

Leader_pep_exosporium

9

IPR021202

21,202

Apoptosis inhibitor Rv3654c-like

Rv3654c-like

Family

3,634

false

This family of proteins from Actinobacteria includes apoptosis inhibitor Rv3654c. Rv3654c is one of two proteins identified in Mycobacterium tuberculosis which are secreted into the host macrophage cytoplasm to suppress apoptosis by blocking the extrinsic pathway, a mechanism to avoid the host defense. Rv3654c recogniz...

[]

0

[ "NCBIFAM" ]

[ "TIGR03816" ]

[ "tadE_like_DECH" ]

[ 3634 ]

1

[ "REACTOME" ]

[ "R-HSA-9635465" ]

[ "REACTOME:R-HSA-9635465" ]

1

[]

0

[ "PUB00082561" ]

[ "20454556" ]

[ "Secreted Mycobacterium tuberculosis Rv3654c and Rv3655c proteins participate in the suppression of macrophage apoptosis." ]

[ 2010 ]

1

[]

0

null

[ "Bacteria", "Pleodorina starrii", "metagenomes" ]

[ 3599, 1, 34 ]

3

[]

0

true

Family

Apoptosis inhibitor Rv3654c-like

Rv3654c-like

8

IPR021203

21,203

Muellerian-inhibiting factor

Muellerian-inhibiting_factor

Family

1,067

false

Muellerian-inhibiting factor, a member of the transforming growth factor beta family, is a glycoprotein hormone that is structurally related to inhibin and activin. It is expressed in male embryos, preventing formation of the Muellerian ducts [ ]. Expression levels in males remain high in early years, but decline aroun...

[]

0

[ "PIRSF", "PANTHER" ]

[ "PIRSF037270", "PTHR15009" ]

[ "Muellerian-inhibiting_factor", "" ]

[ 426, 1067 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-201451", "R-HSA-9690406", "R-MMU-201451", "R-RNO-201451" ]

[ "REACTOME:R-HSA-201451", "REACTOME:R-HSA-9690406", "REACTOME:R-MMU-201451", "REACTOME:R-RNO-201451" ]

4

[ "7l0j", "9ban", "9bao" ]

3

[ "PUB00053476", "PUB00053477", "PUB00053478" ]

[ "7828438", "14742691", "17559842" ]

[ "The in vivo roles of mullerian-inhibiting substance.", "Anti-Mullerian hormone expression pattern in the human ovary: potential implications for initial and cyclic follicle recruitment.", "Mullerian Inhibiting Substance is an ovarian growth factor of emerging clinical significance." ]

[ 1994, 2004, 2007 ]

3

[]

0

null

[ "Vertebrata" ]

[ 1067 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 3, 2, 2 ]

4

true

Family

Muellerian-inhibiting factor

Muellerian-inhibiting_factor

7

IPR021204

21,204

Integrating conjugative element protein, PFL4711

Integr_conj_element_PFL4711

Family

1,869

false

Members of this protein family are found in genomic regions associated with conjugative transfer and integrated TOL-like plasmids. The specific function is unknown.

[]

0

[ "NCBIFAM" ]

[ "TIGR03755" ]

[ "conj_TIGR03755" ]

[ 1869 ]

1

[ "GP" ]

[ "GenProp0855" ]

[ "GP:GenProp0855" ]

1

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 1851, 4, 14 ]

3

[]

0

true

Family

Integrating conjugative element protein, PFL4711

Integr_conj_element_PFL4711

5

IPR021206

21,206

MprA protease C-terminal rhombosortase-interaction domain

MprA_tail

Domain

142

false

This entry describes the Ralstonia lineage variant of the GlyGly-CTERM domain ( ) [ ]. This is a predicted target for protein sorting and cleavage by rhombosortase, a member of the family of rhomboid proteases. The domain occurs in MprA proteases, which are predicted to be serine proteases.

[]

0

[ "NCBIFAM" ]

[ "TIGR03867" ]

[ "MprA_tail" ]

[ 142 ]

1

[ "GP" ]

[ "GenProp0778" ]

[ "GP:GenProp0778" ]

1

[]

0

[ "PUB00060404" ]

[ "22194940" ]

[ "GlyGly-CTERM and rhombosortase: a C-terminal protein processing signal in a many-to-one pairing with a rhomboid family intramembrane serine protease." ]

[ 2011 ]

1

[]

0

null

[ "Bacteria", "Eukaryota" ]

[ 136, 6 ]

2

[]

0

true

Domain

MprA protease C-terminal rhombosortase-interaction domain

MprA_tail

6

IPR021207

21,207

Integrating conjugative element protein, PFL4705

Integr_conj_element_PFL4705

Family

1,866

false

Proteins in this entry are found occasionally on plasmids such as the Pseudomonas putida toluene catabolic TOL plasmid pWWO_p085. Usually, however, they are found on the bacterial main chromosome in regions flanked by markers of conjugative transfer and/or transposition.

[]

0

[ "NCBIFAM" ]

[ "TIGR03752" ]

[ "conj_TIGR03752" ]

[ 1866 ]

1

[ "GP" ]

[ "GenProp0855" ]

[ "GP:GenProp0855" ]

1

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 1843, 4, 19 ]

3

[]

0

true

Family

Integrating conjugative element protein, PFL4705

Integr_conj_element_PFL4705

6

IPR021210

21,210

Exosporium BclB, C-terminal domain

Exosporium_BclB

Domain

792

false

This domain occurs as the C-terminal region in a number of proteins that have extensive collagen-like triple helix repeat regions. Member domains are predicted by TmHMM to have four or five transmembrane helices. Proteins in this entry are found mostly in the Firmicutes, but also in Acanthamoeba polyphaga mimivirus. Th...

[]

0

[ "NCBIFAM" ]

[ "TIGR03721" ]

[ "exospore_TM" ]

[ 792 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Viruses", "metagenomes" ]

[ 759, 26, 7 ]

3

[]

0

true

Domain

Exosporium BclB, C-terminal domain

Exosporium_BclB

4

IPR021211

21,211

Sorting assembly machinery 35kDa subunit

SAM35

Family

499

false

SAM35 is a component of the mitochondrial outer membrane sorting assembly machinery (SAM) complex. It is crucial for the assembly pathway of outer membrane β-barrel proteins, such as the precursors of Tom40 and porin [ ].

[]

0

[ "PFAM" ]

[ "PF10806" ]

[ "SAM35" ]

[ 499 ]

1

[]

0

[ "7btw", "7btx", "7bty", "7e4h", "7e4i", "7vku" ]

6

[ "PUB00074955" ]

[ "15067005" ]

[ "Sam35 of the mitochondrial protein sorting and assembly machinery is a peripheral outer membrane protein essential for cell viability." ]

[ 2004 ]

1

[]

0

null

[ "saccharomyceta" ]

[ 499 ]

1

[ "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)" ]

[ 1 ]

1

true

Family

Sorting assembly machinery 35kDa subunit

SAM35

7

IPR021212

21,212

Domain of unknown function DUF2760

DUF2760

Domain

1,268

false

This is a bacterial family of uncharacterised proteins.

[]

0

[ "PFAM" ]

[ "PF10816" ]

[ "DUF2760" ]

[ 1268 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 1264, 2, 2 ]

3

[]

0

true

Domain

Domain of unknown function DUF2760

DUF2760

9

IPR021213

21,213

Protein of unknown function DUF2567

DUF2567

Family

917

false

This is a bacterial family of proteins with unknown function.

[]

0

[ "PFAM" ]

[ "PF10821" ]

[ "DUF2567" ]

[ 917 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Actinomycetes", "freshwater metagenome" ]

[ 916, 1 ]

2

[]

0

true

Family

Protein of unknown function DUF2567

DUF2567

7

IPR021214

21,214

Protein of unknown function DUF2568

DUF2568

Family

2,031

false

One member in this family is annotated as yrdB which is part of a four gene operon however currently no function is known.

[]

0

[ "PFAM" ]

[ "PF10823" ]

[ "DUF2568" ]

[ 2031 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Halobacteriales", "ecological metagenomes" ]

[ 2022, 6, 3 ]

3

[]

0

true

Family

Protein of unknown function DUF2568

DUF2568

9

IPR021215

21,215

Protein of unknown function DUF2752

DUF2752

Family

7,396

false

This family is conserved in bacteria. Many members are annotated as being putative membrane proteins.

[]

0

[ "PFAM" ]

[ "PF10825" ]

[ "DUF2752" ]

[ 7396 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 7290, 5, 101 ]

3

[]

0

true

Family

Protein of unknown function DUF2752

DUF2752

9

IPR021216

21,216

Protein of unknown function DUF2722

DUF2722

Family

492

false

This eukaryotic family of proteins has no known function.

[]

0

[ "PFAM" ]

[ "PF10846" ]

[ "DUF2722" ]

[ 492 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Opisthokonta" ]

[ 492 ]

1

[ "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)" ]

[ 1 ]

1

true

Family

Protein of unknown function DUF2722

DUF2722

4

IPR021217

21,217

Spiroplasma phage 1-C74, Orf10

Phage_1-C74_Orf10

Family

86

false

This entry is represented by Spiroplasma phage 1-C74, Orf10. The characteristics of the protein distribution suggest prophage matches in addition to the phage matches. Members in this family of proteins are also annotated as Plectrovirus orf 10 transmembrane proteins however currently no function is known.

[]

0

[ "PFAM" ]

[ "PF10854" ]

[ "DUF2649" ]

[ 86 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Plectroviridae", "Spiroplasma" ]

[ 4, 82 ]

2

[]

0

true

Family

Spiroplasma phage 1-C74, Orf10

Phage_1-C74_Orf10

1

IPR021218

21,218

Protein of unknown function DUF2784

DUF2784

Family

2,802

false

This is a family of uncharacterised protein. The function is not known however it is conserved in Bacteria.

[]

0

[ "PFAM" ]

[ "PF10861" ]

[ "DUF2784" ]

[ 2802 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Klosneuvirinae", "metagenomes", "uncultured marine group II/III euryarchaeote KM3_87_G01" ]

[ 2746, 3, 51, 2 ]

4

[]

0

true

Family

Protein of unknown function DUF2784

DUF2784

9

IPR021219

21,219

Protein of unknown function DUF2703

DUF2703

Family

423

false

This family of protein has no known function.

[]

0

[ "PFAM" ]

[ "PF10865" ]

[ "DUF2703" ]

[ 423 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria", "ecological metagenomes" ]

[ 79, 320, 24 ]

3

[]

0

true

Family

Protein of unknown function DUF2703

DUF2703

9

IPR021220

21,220

Protein of unknown function DUF2686

DUF2686

Family

296

false

Some members in this family of proteins are annotated as yjfZ however currently no function is known.

[]

0

[ "PFAM" ]

[ "PF10887" ]

[ "DUF2686" ]

[ 296 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "human gut metagenome" ]

[ 291, 5 ]

2

[ "Escherichia coli (strain K12)" ]

[ 2 ]

1

true

Family

Protein of unknown function DUF2686

DUF2686

2

IPR021221

21,221

Protein fil

Fil

Family

1,069

false

This entry represents Protein fil from Escherichia phage 186 (Bacteriophage 186). Fil is thought to cause filamentation. The characteristics of the protein distribution suggest prophage matches in addition to the phage matches.

[]

0

[ "PFAM" ]

[ "PF10893" ]

[ "Phage_186_Fil" ]

[ 1069 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Caudoviricetes", "feces metagenome" ]

[ 1024, 44, 1 ]

3

[]

0

true

Family

Protein fil

Fil

7

IPR021222

21,222

Protein of unknown function DUF2714

DUF2714

Family

181

false

This family of proteins with unknown function appears to be restricted to Mycoplasmataceae.

[]

0

[ "PFAM" ]

[ "PF10896" ]

[ "DUF2714" ]

[ 181 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacillati", "Corchorus capsularis" ]

[ 180, 1 ]

2

[]

0

true

Family

Protein of unknown function DUF2714

DUF2714

7

IPR021223

21,223

Abortive phage resistance protein AbiGi

AbiGi

Family

490

false

This is a bacterial family of proteins with unknown function. AbiGi is a family of putative type IV toxin-antitoxin system antitoxins. The AbiG abortive phage resistance system affects lactococcal bacteriophages phiP335 and phiQ30 but not the other P335 phage species. AbiGii toxin appears to confer resistance to phages...

[]

0

[ "PFAM" ]

[ "PF10899" ]

[ "AbiGi" ]

[ 490 ]

1

[]

0

[]

0

[ "PUB00016885" ]

[ "12023079" ]

[ "Effectiveness of the lactococcal abortive infection systems AbiA, AbiE, AbiF and AbiG against P335 type phages." ]

[ 2002 ]

1

[]

0

null

[ "Bacteria", "Methanosarcinales", "Syncephalis pseudoplumigaleata", "unclassified sequences" ]

[ 475, 2, 1, 12 ]

4

[]

0

true

Family

Abortive phage resistance protein AbiGi

AbiGi

1

IPR021224

21,224

Protein of unknown function DUF2690

DUF2690

Family

2,438

false

This bacterial family of proteins has no known function.

[]

0

[ "PFAM" ]

[ "PF10901" ]

[ "DUF2690" ]

[ 2438 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Leptosphaeria maculans (strain JN3 / isolate v23.1.3 / race Av1-4-5-6-7-8)" ]

[ 2437, 1 ]

2

[]

0

true

Family

Protein of unknown function DUF2690

DUF2690

2

IPR021225

21,225

Tlde1 domain

Tlde1_dom

Domain

2,484

false

This domain is found in Tlde1 family of antibacterial effectors secreted by the type VI secretion system (T6SS). Tlde1 family is evolutionarily related to l, d transpeptidases which form mDAP3-mDAP3 peptidoglycan crosslinks. Tlde1 family is widespread among Proteobacteria and is divided into three subfamilies (Tlde1a, ...

[]

0

[ "PFAM" ]

[ "PF10908" ]

[ "Tlde1_dom" ]

[ 2484 ]

1

[]

0

[]

0

[ "PUB00100165" ]

[ "32579939" ]

[ "A Family of T6SS Antibacterial Effectors Related to l,d-Transpeptidases Targets the Peptidoglycan." ]

[ 2020 ]

1

[]

0

null

[ "Bacteria", "Caudoviricetes", "Eukaryota", "unclassified sequences" ]

[ 2407, 26, 40, 11 ]

4

[]

0

true

Domain

Tlde1 domain

Tlde1_dom

9

IPR021226

21,226

Phage gene 29 protein

Phage_gene29

Family

816

false

This entry represents a family of phage proteins related to gene 29 protein from Mycobacterium phage D29 and L5. The function of the proteins in this family is unknown. AlphaFold multimer shows that the proteins in the family adopt a confident dimeric structure. The individual proteins are not compact in isolated struc...

[]

0

[ "PFAM" ]

[ "PF10910" ]

[ "Phage_gene29" ]

[ 816 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Viruses" ]

[ 222, 594 ]

2

[]

0

true

Family

Phage gene 29 protein

Phage_gene29

1

IPR021228

21,228

BREX system ATP-binding protein BrxD

BrxD

Family

2,797

false

This is a family of proteins found in bacterial proteins associated with Bacteriophage Exclusion (BREX) system, a defense system that allows bacteriophage adsorption but blocks phage DNA replication [ ]. This family represents the ATP-binding protein BrxD [ ].

[]

0

[ "PFAM" ]

[ "PF10923" ]

[ "BrxC_BrxD" ]

[ 2797 ]

1

[]

0

[]

0

[ "PUB00093365" ]

[ "25452498" ]

[ "BREX is a novel phage resistance system widespread in microbial genomes." ]

[ 2015 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Siphoviridae sp. ctCsv15", "unclassified sequences" ]

[ 120, 2635, 6, 1, 35 ]

5

[]

0

true

Family

BREX system ATP-binding protein BrxD

BrxD

3

IPR021229

21,229

Protein of unknown function DUF2800

DUF2800

Family

2,075

false

This is a family of uncharacterised proteins found in bacteria and viruses.

[]

0

[ "PFAM" ]

[ "PF10926" ]

[ "DUF2800" ]

[ 2075 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Viruses", "metagenomes" ]

[ 1460, 13, 564, 38 ]

4

[]

0

true

Family

Protein of unknown function DUF2800

DUF2800

3

IPR021230

21,230

Protein of unknown function DUF2810

DUF2810

Family

1,399

false

This is a bacterial family of uncharacterised proteins. This entry contains YibL ( ), which comigrates with the mature 50S ribosome subunit. It either represents a novel ribosome-associated protein or it is associated with a different oligomeric complex that comigrates with ribosomal particles [ ].

[]

0

[ "PFAM" ]

[ "PF10928" ]

[ "DUF2810" ]

[ 1399 ]

1

[]

0

[ "2lf0" ]

1

[ "PUB00045877" ]

[ "16980477" ]

[ "The Escherichia coli GTPase CgtAE is involved in late steps of large ribosome assembly." ]

[ 2006 ]

1

[]

0

null

[ "Bacteria", "Beauveria bassiana D1-5", "human gut metagenome" ]

[ 1397, 1, 1 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Protein of unknown function DUF2810

DUF2810

3

IPR021231

21,231

Protein of unknown function DUF2811

DUF2811

Family

425

false

This is a bacterial family of uncharacterised proteins. It contains an all-helical fold.

[]

0

[ "PFAM" ]

[ "PF10929" ]

[ "DUF2811" ]

[ 425 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Cyanobacteriota", "Stygiolobus" ]

[ 423, 2 ]

2

[]

0

true

Family

Protein of unknown function DUF2811

DUF2811

5

IPR021232

21,232

Protein of unknown function DUF2735

DUF2735

Family

557

false

Some members in this family of proteins are annotated as glutamine synthetase translation inhibitor however this function can not be confirmed.

[]

0

[ "PFAM" ]

[ "PF10931" ]

[ "DUF2735" ]

[ 557 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Alphaproteobacteria" ]

[ 557 ]

1

[]

0

true

Family

Protein of unknown function DUF2735

DUF2735

2

IPR021233

21,233

Protein of unknown function DUF2783

DUF2783

Family

1,802

false

This is a bacterial family of uncharacterised protein.

[]

0

[ "PFAM" ]

[ "PF10932" ]

[ "DUF2783" ]

[ 1802 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "unclassified sequences" ]

[ 1787, 15 ]

2

[]

0

true

Family

Protein of unknown function DUF2783

DUF2783

7

IPR021234

21,234

Protein of unknown function DUF2827

DUF2827

Family

1,109

false

This is a family of uncharacterised proteins found mostly in Burkholderia.

[]

0

[ "PFAM" ]

[ "PF10933" ]

[ "DUF2827" ]

[ 1109 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Pyramimonas orientalis virus 01B", "metagenomes", "miscellaneous Crenarchaeota group-1 archaeon SG8-32-1" ]

[ 1049, 6, 1, 52, 1 ]

5

[]

0

true

Family

Protein of unknown function DUF2827

DUF2827

4

IPR021235

21,235

Protein of unknown function DUF2637

DUF2637

Family

8,074

false

This family of proteins has no known function.

[]

0

[ "PFAM" ]

[ "PF10935" ]

[ "DUF2637" ]

[ 8074 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Acrobeloides nanus", "Bacteria", "Methanospirillum", "Viruses", "ecological metagenomes" ]

[ 1, 7732, 8, 331, 2 ]

5

[]

0

true

Family

Protein of unknown function DUF2637

DUF2637

1

IPR021236

21,236

Uncharacterised protein family YfdX

Uncharacterised_YfdX

Family

1,671

false

YfdX is a protein found in Proteobacteria of unknown function. The protein coding for this gene is regulated by EvgA in Escherichia coli [ ].

[]

0

[ "NCBIFAM", "PFAM" ]

[ "NF007645", "PF10938" ]

[ "PRK10316.1", "YfdX" ]

[ 668, 1671 ]

2

[]

0

[ "3dza", "6a02", "6a07", "6a09", "6uxt" ]

5

[ "PUB00053495" ]

[ "12670992" ]

[ "Global analysis of genes regulated by EvgA of the two-component regulatory system in Escherichia coli." ]

[ 2003 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "Thermococcus", "metagenomes" ]

[ 1645, 2, 2, 22 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Uncharacterised protein family YfdX

Uncharacterised_YfdX

7

IPR021237

21,237

Leader peptide SpeFL

SpeFL

Family

445

false

SpeFL is a small protein (arrest peptide) encoded upstream of inducible ornithine carboxylase gene (speF) that controls expression of downstream genes (speF and patE) by nascent chain-translational arrest and transcriptional attenuation [ ]. Ornithine capture by a translating ribosome controls bacterial polyamine synth...

[]

0

[ "HAMAP", "PFAM" ]

[ "MF_00851", "PF10940" ]

[ "Leader_SpeFL", "SpeFL" ]

[ 409, 440 ]

2

[]

0

[ "6tbv", "6tc3" ]

2

[ "PUB00095673", "PUB00098030" ]

[ "3209458", "32094585" ]

[ "Disseminated hemangiosarcoma in a horse.", "Ornithine capture by a translating ribosome controls bacterial polyamine synthesis." ]

[ 1988, 2020 ]

2

[]

0

null

[ "Bacteria" ]

[ 445 ]

1

[ "Escherichia coli (strain K12)" ]

[ 2 ]

1

true

Family

Leader peptide SpeFL

SpeFL

1

IPR021238

21,238

Protein of unknown function DUF2620

DUF2620

Family

762

false

This is a bacterial family of proteins with unknown function.

[]

0

[ "PFAM" ]

[ "PF10941" ]

[ "DUF2620" ]

[ 762 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "metagenomes" ]

[ 756, 6 ]

2

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Protein of unknown function DUF2620

DUF2620

2

IPR021239

21,239

Protein of unknown function DUF2625

DUF2625

Family

1,145

false

Some members in this family of proteins are annotated as ybfG however currently no function is known.

[]

0

[ "PFAM" ]

[ "PF10946" ]

[ "DUF2625" ]

[ 1145 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "bioreactor metagenome" ]

[ 1130, 11, 4 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Protein of unknown function DUF2625

DUF2625

8

IPR021240

21,240

Protein of unknown function DUF2776

DUF2776

Family

547

false

This bacterial family of proteins has no known function.

[]

0

[ "PFAM" ]

[ "PF10951" ]

[ "DUF2776" ]

[ 547 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Candidatus Methanomassiliicoccus intestinalis", "human gut metagenome" ]

[ 543, 2, 2 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Protein of unknown function DUF2776

DUF2776

6

IPR021241

21,241

Peptidoglycan-binding protein, CsiV

CsiV

Family

2,105

false

CsiV, a small periplasmic protein (cell-shape integrity in Vibrio), is essential for growth of Vibrio cholerae in the presence of DAA, non-canonical amino-acids, the typical components of peptidoglycan side-chains in Vibrio cholerae. CsiV interacts with LpoA, the lipoprotein activator of penicillin-binding-protein1A th...

[]

0

[ "PFAM" ]

[ "PF10972" ]

[ "CsiV" ]

[ 2105 ]

1

[]

0

[]

0

[ "PUB00075620" ]

[ "24945690" ]

[ "A novel peptidoglycan binding protein crucial for PBP1A-mediated cell wall biogenesis in Vibrio cholerae." ]

[ 2014 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 2059, 3, 43 ]

3

[]

0

true

Family

Peptidoglycan-binding protein, CsiV

CsiV

3

IPR021242

21,242

Protein of unknown function DUF2799

DUF2799

Family

2,119

false

Some members in this family of proteins are annotated as yfiL which has no known function.

[]

0

[ "PFAM" ]

[ "PF10973" ]

[ "DUF2799" ]

[ 2119 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Symbiodiniaceae", "ecological metagenomes" ]

[ 2114, 3, 2 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Protein of unknown function DUF2799

DUF2799

8

IPR021243

21,243

Protein of unknown function DUF2804

DUF2804

Family

2,949

false

This is a family of proteins with unknown function. Members are predicted to fold into a double barrel-like structure consisting of two co-join barrels predicted to be structurally similar to , with a lipocalin fold ( ) [ ].

[]

0

[ "PFAM", "PANTHER" ]

[ "PF10974", "PTHR35868" ]

[ "DUF2804", "" ]

[ 2948, 2887 ]

2

[]

0

[]

0

[ "PUB00055863", "PUB00152793" ]

[ "20944205", "36419248" ]

[ "Structure of the first representative of Pfam family PF09410 (DUF2006) reveals a structural signature of the calycin superfamily that suggests a role in lipid metabolism.", "DALI shines a light on remote homologs: One hundred discoveries." ]

[ 2010, 2023 ]

2

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 12, 2733, 170, 34 ]

4

[]

0

true

Family

Protein of unknown function DUF2804

DUF2804

2

IPR021245

21,245

Protein of unknown function DUF2790

DUF2790

Family

3,561

false

This family of proteins with unknown function appear to be restricted to Pseudomonadaceae.

[]

0

[ "PFAM" ]

[ "PF10976" ]

[ "DUF2790" ]

[ 3561 ]

1

[]

0

[ "4f98" ]

1

[]

0

[]

0

null

[ "Bacteria", "Rhabditida", "marine sediment metagenome" ]

[ 3556, 2, 3 ]

3

[]

0

true

Family

Protein of unknown function DUF2790

DUF2790

1

IPR021246

21,246

Protein of unknown function DUF2797

DUF2797

Family

5,186

false

This family of proteins has no known function.

[]

0

[ "PFAM" ]

[ "PF10977" ]

[ "DUF2797" ]

[ 5186 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 365, 4748, 3, 70 ]

4

[]

0

true

Family

Protein of unknown function DUF2797

DUF2797

4

IPR021247

21,247

Protein of unknown function DUF2785

DUF2785

Family

2,569

false

Some members in this family are annotated as hypothetical membrane spanning proteins however this cannot be confirmed. The family has no known function.

[]

0

[ "PFAM" ]

[ "PF10978" ]

[ "DUF2785" ]

[ 2569 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Rhizophagus irregularis", "metagenomes" ]

[ 2, 2554, 1, 12 ]

4

[]

0

true

Family

Protein of unknown function DUF2785

DUF2785

6

IPR021248

21,248

Protein of unknown function DUF2787

DUF2787

Family

1,091

false

This family of proteins, predominantly found in Gammaproteobacteria, has no known function. The conserved hypothetical protein VC1805 from Vibrio cholerae is included in this entry. VC1805 adopts a monomeric assembly, showing an unusual topology with a flat seven-stranded anti-parallel β-sheet and two helices located o...

[]

0

[ "PFAM", "PANTHER" ]

[ "PF10980", "PTHR38978" ]

[ "DUF2787", "" ]

[ 1091, 1075 ]

2

[]

0

[ "2v1l", "2w56" ]

2

[ "PUB00049533" ]

[ "18300248" ]

[ "Crystal structure of VC1805, a conserved hypothetical protein from a Vibrio cholerae pathogenicity island, reveals homology to human p32." ]

[ 2008 ]

1

[]

0

null

[ "Bacteria", "ecological metagenomes" ]

[ 1088, 3 ]

2

[]

0

true

Family

Protein of unknown function DUF2787

DUF2787

1

IPR021249

21,249

Protein of unknown function DUF2788

DUF2788

Family

2,103

false

This bacterial family of proteins have no known function.

[]

0

[ "PFAM" ]

[ "PF10981" ]

[ "DUF2788" ]

[ 2103 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "metagenomes" ]

[ 2090, 13 ]

2

[]

0

true

Family

Protein of unknown function DUF2788

DUF2788

1

IPR021250

21,250

Protein of unknown function DUF2789

DUF2789

Family

3,000

false

This bacterial family of proteins has no known function.

[]

0

[ "PFAM" ]

[ "PF10982" ]

[ "DUF2789" ]

[ 3000 ]

1

[]

0

[ "2kp6" ]

1

[]

0

[]

0

null

[ "Bacteria", "Ecdysozoa", "ecological metagenomes" ]

[ 2987, 4, 9 ]

3

[]

0

true

Family

Protein of unknown function DUF2789

DUF2789

8

IPR021252

21,252

Protein of unknown function DUF2794

DUF2794

Family

2,463

false

This is a bacterial family of proteins with unknown function.

[]

0

[ "PFAM" ]

[ "PF10984" ]

[ "DUF2794" ]

[ 2463 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Diploscapter pachys", "ecological metagenomes" ]

[ 2427, 1, 35 ]

3

[]

0

true

Family

Protein of unknown function DUF2794

DUF2794

2

IPR021253

21,253

Zinc-specific solute binding protein ZrgA

ZrgA-like

Family

2,242

false

This entry, previously known as DUF2796, represents the zinc-specific solute binding protein ZrgA homologues found predominantly in gammaproteobacteria. ZrgA is an important component of the zrgABCDE operon in Vibrio parahaemolyticus and Vibrio cholerae. It is anticipated to function as a solute binding protein (SBP) f...

[]

0

[ "PFAM" ]

[ "PF10986" ]

[ "ZrgA" ]

[ 2242 ]

1

[]

0

[ "7ahw", "7aly", "7amx", "7bgo", "8ezw", "8f1b" ]

6

[ "PUB00159002", "PUB00159005", "PUB00159006" ]

[ "36482737", "36613986", "34726168" ]

[ "ZrgA contributes to zinc acquisition in Vibrio parahaemolyticus.", "Structure and Function of the Zinc Binding Protein ZrgA from Vibrio cholerae.", "Structure and metal-binding properties of PA4063, a novel player in periplasmic zinc trafficking by Pseudomonas aeruginosa." ]

[ 2023, 2022, 2021 ]

3

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 2220, 5, 17 ]

3

[]

0

true

Family

Zinc-specific solute binding protein ZrgA

ZrgA-like

8

IPR021254

21,254

Protein of unknown function DUF2806

DUF2806

Family

1,219

false

This bacterial family of proteins has no known function.

[]

0

[ "PFAM", "NCBIFAM" ]

[ "PF10987", "TIGR03899" ]

[ "DUF2806", "" ]

[ 1219, 726 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Candidatus Argoarchaeum ethanivorans", "Discina gigas", "Siphoviridae sp. ctbrg2", "ecological metagenomes" ]

[ 1203, 1, 1, 1, 13 ]

5

[]

0

true

Family

Protein of unknown function DUF2806

DUF2806

5