interpro_id string | interpro_numeric_id int64 | name string | short_name string | entry_type string | protein_count int64 | is_llm bool | is_llm_reviewed bool | abstract string | go_ids list | go_terms list | go_categories list | go_count int64 | member_databases list | member_accessions list | member_names list | member_protein_counts list | member_count int64 | external_databases list | external_accessions list | external_xrefs list | external_xref_count int64 | pdb_ids list | structure_count int64 | publication_ids list | pubmed_ids list | publication_titles list | publication_years list | publication_count int64 | parent_ids list | child_ids list | parent_count int64 | child_count int64 | tree_depth float64 | taxonomy_names list | taxonomy_protein_counts list | taxonomy_count int64 | key_species_names list | key_species_protein_counts list | key_species_count int64 | in_entry_list bool | entry_list_type string | entry_list_name string | names_dat_name string | short_names_dat_name string | split_bucket int64 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
IPR021626 | 21,626 | Plasmodium falciparum UIS3 membrane protein | PfUIS3 | Family | 61 | false | false | UIS3 is a membrane protein essential for sporozoite development in infected hepatocytes. This family is 130-229 of the Plasmodium falciparum UIS3 protein which is compact and has an all α-helical structure. PfUIS3(130-229) interacts with lipids, phospholipid lysosomes, the human liver fatty acid-binding protein and wit... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF11567"
] | [
"PfUIS3"
] | [
61
] | 1 | [] | [] | [] | 0 | [
"2vwa"
] | 1 | [
"PUB00049933"
] | [
"18577521"
] | [
"Crystal structure of soluble domain of malaria sporozoite protein UIS3 in complex with lipid."
] | [
2008
] | 1 | [] | [] | 0 | 0 | null | [
"Plasmodium"
] | [
61
] | 1 | [] | [] | 0 | true | Family | Plasmodium falciparum UIS3 membrane protein | Plasmodium falciparum UIS3 membrane protein | PfUIS3 | 8 |
IPR021627 | 21,627 | Mediator complex, subunit Med27 | Mediator_Med27 | Family | 3,382 | false | false | Mediator is a large complex of up to 33 proteins that is conserved from plants to fungi to humans - the number and representation of individual subunits varying with species. It is arranged into four different sections, a core, a head, a tail and a kinase-activity part, and the number of subunits within each of these i... | [
"GO:0016592"
] | [
"mediator complex"
] | [
"cellular_component"
] | 1 | [
"PFAM",
"PANTHER"
] | [
"PF11571",
"PTHR13130"
] | [
"Med27",
""
] | [
2954,
2745
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-212436",
"R-BTA-9841922",
"R-DME-9841922",
"R-HSA-1989781",
"R-HSA-212436",
"R-HSA-381340",
"R-HSA-9833110",
"R-HSA-9841922",
"R-SSC-212436",
"R-SSC-9841922"
] | [
"REACTOME:R-BTA-212436",
"REACTOME:R-BTA-9841922",
"REACTOME:R-DME-9841922",
"REACTOME:R-HSA-1989781",
"REACTOME:R-HSA-212436",
"REACTOME:R-HSA-381340",
"REACTOME:R-HSA-9833110",
"REACTOME:R-HSA-9841922",
"REACTOME:R-SSC-212436",
"REACTOME:R-SSC-9841922"
] | 10 | [
"5u0p",
"5u0s",
"6w1s",
"7emf",
"7ena",
"7enc",
"7enj",
"7lbm",
"7nvr",
"8gxq",
"8gxs",
"8t1i",
"8t1l",
"8t9d",
"8tqw",
"8trh"
] | 16 | [
"PUB00050849",
"PUB00053506"
] | [
"18381891",
"16582438"
] | [
"Structure-system correlation identifies a gene regulatory Mediator submodule.",
"Differential roles of transcriptional mediator complex subunits Crsp34/Med27, Crsp150/Med14 and Trap100/Med24 during zebrafish retinal development."
] | [
2008,
2006
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
3382
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)",
"Zea mays"
] | [
3,
2,
19,
1,
6,
4,
4,
6,
1,
18
] | 10 | true | Family | Mediator complex, subunit Med27 | Mediator complex, subunit Med27 | Mediator_Med27 | 1 |
IPR021628 | 21,628 | Protein of unknown function DUF3234 | DUF3234 | Family | 32 | false | false | This bacterial family of proteins has no known function. Some members in this family of proteins are annotated as TTHA0547 however this cannot be confirmed. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF11572"
] | [
"DUF3234"
] | [
32
] | 1 | [] | [] | [] | 0 | [
"2z0r"
] | 1 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Thermaceae"
] | [
32
] | 1 | [] | [] | 0 | true | Family | Protein of unknown function DUF3234 | Protein of unknown function DUF3234 | DUF3234 | 8 |
IPR021629 | 21,629 | Mediator complex, subunit Med23 | Mediator_Med23 | Family | 3,826 | false | false | Med23 is one of the subunits of the Tail portion of the Mediator complex that regulates RNA polymerase II activity. Med23 is required for heat-shock-specific gene expression, and has been shown to mediate transcriptional activation of E1A in mice. | [] | [] | [] | 0 | [
"PFAM",
"PANTHER"
] | [
"PF11573",
"PTHR12691"
] | [
"Med23",
""
] | [
3531,
3749
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-DME-9841922",
"R-HSA-1989781",
"R-HSA-212436",
"R-HSA-381340",
"R-HSA-9833110",
"R-HSA-9841922",
"R-RNO-9841922"
] | [
"REACTOME:R-DME-9841922",
"REACTOME:R-HSA-1989781",
"REACTOME:R-HSA-212436",
"REACTOME:R-HSA-381340",
"REACTOME:R-HSA-9833110",
"REACTOME:R-HSA-9841922",
"REACTOME:R-RNO-9841922"
] | 7 | [
"6h02",
"6w1s",
"7emf",
"7ena",
"7enc",
"7enj",
"7lbm",
"8gxq",
"8gxs",
"8t1i",
"8t1l",
"8t9d",
"8tqw",
"8trh",
"9f6y",
"9f76"
] | 16 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
3826
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
7,
1,
5,
1,
9,
7,
4,
7,
37
] | 9 | true | Family | Mediator complex, subunit Med23 | Mediator complex, subunit Med23 | Mediator_Med23 | 6 |
IPR021630 | 21,630 | Resuscitation-promoting factor Rpf1, C-terminal | Rpf1_C | Domain | 369 | false | false | This entry represents the C-terminal domain of Resuscitation-promoting factor Rpf1 from Corynebacterium glutamicum, a factor that stimulates resuscitation or dormant cells [ ]. The function of this domain is not known. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF11574"
] | [
"Rpf1_C"
] | [
369
] | 1 | [] | [] | [] | 0 | [
"3b4q"
] | 1 | [
"PUB00097296"
] | [
"15480574"
] | [
"The glycosylated cell surface protein Rpf2, containing a resuscitation-promoting factor motif, is involved in intercellular communication of Corynebacterium glutamicum."
] | [
2004
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Rhodotorula toruloides",
"freshwater metagenome"
] | [
364,
4,
1
] | 3 | [] | [] | 0 | true | Domain | Resuscitation-promoting factor Rpf1, C-terminal | Resuscitation-promoting factor Rpf1, C-terminal | Rpf1_C | 4 |
IPR021631 | 21,631 | Protein of unknown function DUF3238 | DUF3238 | Family | 583 | false | false | Proteins in this family are not characterised. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF11579"
] | [
"DUF3238"
] | [
583
] | 1 | [] | [] | [] | 0 | [
"3c5p"
] | 1 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Fungi",
"Halobacteriales"
] | [
550,
28,
5
] | 3 | [] | [] | 0 | true | Family | Protein of unknown function DUF3238 | Protein of unknown function DUF3238 | DUF3238 | 2 |
IPR021632 | 21,632 | Protein of unknown function DUF3239 | DUF3239 | Family | 507 | false | false | This entry contains possible membrane proteins, however this cannot be confirmed. Currently they have no known function. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF11580"
] | [
"DUF3239"
] | [
507
] | 1 | [] | [] | [] | 0 | [
"3c8i"
] | 1 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Didymella rabiei",
"freshwater metagenome"
] | [
505,
1,
1
] | 3 | [] | [] | 0 | true | Family | Protein of unknown function DUF3239 | Protein of unknown function DUF3239 | DUF3239 | 8 |
IPR021633 | 21,633 | Antagonist of EGFR signalling, Argos | Argos | Family | 306 | false | false | Argos is a natural secreted antagonist of EGFR signalling which functions by binding growth factor ligands that activate EGFR by forming a clamp like structure using three disulphide-bonded β-sheet domains [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF11581"
] | [
"Argos"
] | [
306
] | 1 | [] | [] | [] | 0 | [
"3c9a",
"3cgu"
] | 2 | [
"PUB00050935"
] | [
"18500331"
] | [
"Structural basis for EGFR ligand sequestration by Argos."
] | [
2008
] | 1 | [] | [] | 0 | 0 | null | [
"Panarthropoda"
] | [
306
] | 1 | [
"Drosophila melanogaster"
] | [
1
] | 1 | true | Family | Antagonist of EGFR signalling, Argos | Antagonist of EGFR signalling, Argos | Argos | 9 |
IPR021634 | 21,634 | Protein of unknown function DUF3240 | DUF3240 | Family | 700 | false | false | This family of proteins with unknown function appears to be restricted to Proteobacteria. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF11582"
] | [
"DUF3240"
] | [
700
] | 1 | [] | [] | [] | 0 | [
"3ce8"
] | 1 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Gibberella intermedia",
"ecological metagenomes"
] | [
689,
1,
10
] | 3 | [] | [] | 0 | true | Family | Protein of unknown function DUF3240 | Protein of unknown function DUF3240 | DUF3240 | 2 |
IPR021635 | 21,635 | Proteinaceous host-selective toxin ToxA | Toxin_ToxA | Family | 55 | false | false | ToxA is produced by particular Pyrenophora triticirepentis races and is a proteinaceous host-selective toxin. It is necessary and sufficient to cause cell death in sensitive wheat cultivars [ ]. ToxA adopts a single-domain, β-sandwich fold which has novel topology. The protein is directly involved in recognition events... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF11584"
] | [
"Toxin_ToxA"
] | [
55
] | 1 | [] | [] | [] | 0 | [
"1zld",
"1zle"
] | 2 | [
"PUB00038931"
] | [
"16214901"
] | [
"Structure of Ptr ToxA: an RGD-containing host-selective toxin from Pyrenophora tritici-repentis."
] | [
2005
] | 1 | [] | [] | 0 | 0 | null | [
"Dothideomycetes"
] | [
55
] | 1 | [] | [] | 0 | true | Family | Proteinaceous host-selective toxin ToxA | Proteinaceous host-selective toxin ToxA | Toxin_ToxA | 9 |
IPR021636 | 21,636 | Protein of unknown function DUF3242 | DUF3242 | Family | 26 | false | false | This entry includes homologues of the uncharacterised TM1622 protein from Thermotoga maritima, for which the structure has been determined. The protein is composed of seven β strands and three α-helices [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF11586"
] | [
"DUF3242"
] | [
26
] | 1 | [] | [] | [] | 0 | [
"1vr8"
] | 1 | [
"PUB00037978"
] | [
"16948158"
] | [
"Crystal structure of an ORFan protein (TM1622) from Thermotoga maritima at 1.75 A resolution reveals a fold similar to the Ran-binding protein Mog1p."
] | [
2006
] | 1 | [] | [] | 0 | 0 | null | [
"Thermotogales"
] | [
26
] | 1 | [] | [] | 0 | true | Family | Protein of unknown function DUF3242 | Protein of unknown function DUF3242 | DUF3242 | 6 |
IPR021637 | 21,637 | Protein of unknown function DUF3243 | DUF3243 | Family | 1,995 | false | false | This family of proteins with unknown function includes uncharacterised proteins ymfJ and yflH. The family appears to be restricted to Firmicutes. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF11588"
] | [
"DUF3243"
] | [
1995
] | 1 | [] | [] | [] | 0 | [
"3d0w"
] | 1 | [] | [] | [] | [] | 0 | [] | [
"IPR024702"
] | 0 | 1 | 0 | [
"Bacteria",
"Methanonatronarchaeaceae",
"Phytophthora kernoviae 00238/432",
"ecological metagenomes"
] | [
1987,
3,
2,
3
] | 4 | [] | [] | 0 | true | Family | Protein of unknown function DUF3243 | Protein of unknown function DUF3243 | DUF3243 | 9 |
IPR021638 | 21,638 | Protein of unknown function DUF3244 | DUF3244 | Family | 824 | false | false | This family of proteins with unknown function appear to have an immunoglobulin-like β-sandwich fold. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF11589"
] | [
"DUF3244"
] | [
824
] | 1 | [] | [] | [] | 0 | [
"3d33",
"3sd2",
"4g5a",
"5hl3"
] | 4 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Methanococcus maripaludis",
"bioreactor metagenome"
] | [
816,
5,
3
] | 3 | [] | [] | 0 | true | Family | Protein of unknown function DUF3244 | Protein of unknown function DUF3244 | DUF3244 | 8 |
IPR021639 | 21,639 | DNA polymerase catalytic subunit Pol, C-terminal | DNAPolymera_Pol_C | Domain | 409 | false | false | This family of proteins represents the catalytic subunit, Pol, of the Herpes simplex virus DNA polymerase. Pol binds UL42, making up the DNA polymerase. UL42 is a processivity subunit which binds to the C-terminal of Pol in a similar way that the cell cycle regulator p21 binds to PCNA [ ]. | [
"GO:0003887",
"GO:0004523"
] | [
"DNA-directed DNA polymerase activity",
"RNA-DNA hybrid ribonuclease activity"
] | [
"molecular_function",
"molecular_function"
] | 2 | [
"PFAM"
] | [
"PF11590"
] | [
"DNAPolymera_Pol"
] | [
409
] | 1 | [
"EC",
"EC"
] | [
"2.7.7.7",
"3.1.26.4"
] | [
"EC:2.7.7.7",
"EC:3.1.26.4"
] | 2 | [
"1b44",
"1dml",
"2gv9",
"8exx",
"8oj6",
"8oj7",
"8oja",
"8ojb",
"8ojc",
"8ojd",
"8v1q",
"8v1r",
"8v1s",
"8v1t",
"9enp",
"9enq",
"9ja3"
] | 17 | [
"PUB00009047"
] | [
"10882068"
] | [
"The crystal structure of an unusual processivity factor, herpes simplex virus UL42, bound to the C terminus of its cognate polymerase."
] | [
2000
] | 1 | [] | [] | 0 | 0 | null | [
"Alphaherpesvirinae"
] | [
409
] | 1 | [] | [] | 0 | true | Domain | DNA polymerase catalytic subunit Pol, C-terminal | DNA polymerase catalytic subunit Pol, C-terminal | DNAPolymera_Pol_C | 3 |
IPR021641 | 21,641 | Protein of unknown function DUF3245 | DUF3245 | Family | 1,265 | false | false | This is a family of proteins conserved in fungi. The function is not known, and there is no S. cerevisiae member. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF11595"
] | [
"DUF3245"
] | [
1265
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1265
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)",
"Zea mays"
] | [
7,
2,
1,
4
] | 4 | true | Family | Protein of unknown function DUF3245 | Protein of unknown function DUF3245 | DUF3245 | 7 |
IPR021642 | 21,642 | Protein of unknown function DUF3246 | DUF3246 | Family | 22 | false | false | This is a small family of fungal proteins one of whose members, from Pichia stipitis is described as being an extremely serine rich protein-mucin-like protein. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF11596"
] | [
"DUF3246"
] | [
22
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Debaryomycetaceae"
] | [
22
] | 1 | [] | [] | 0 | true | Family | Protein of unknown function DUF3246 | Protein of unknown function DUF3246 | DUF3246 | 1 |
IPR021643 | 21,643 | Mediator complex, subunit Med13, N-terminal | Mediator_Med13_N | Domain | 3,870 | false | false | This entry represents the N-terminal domain of Med13. Mediator is a large complex of up to 33 proteins that is conserved from plants through fungi to humans - the number and representation of individual subunits varying with species [ , ]. It is arranged into four different sections, a core, a head, a tail and a kinase... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF11597"
] | [
"Med13_N"
] | [
3870
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-DME-9841922",
"R-HSA-1989781",
"R-HSA-381340",
"R-HSA-9833110"
] | [
"REACTOME:R-DME-9841922",
"REACTOME:R-HSA-1989781",
"REACTOME:R-HSA-381340",
"REACTOME:R-HSA-9833110"
] | 4 | [
"7kpv",
"7kpx"
] | 2 | [
"PUB00012328",
"PUB00033372",
"PUB00053524",
"PUB00094411"
] | [
"12738880",
"15175151",
"18451032",
"17290221"
] | [
"TRAP230/ARC240 and TRAP240/ARC250 Mediator subunits are functionally conserved through evolution.",
"A unified nomenclature for protein subunits of mediator complexes linking transcriptional regulators to RNA polymerase II.",
"Pygopus activates Wingless target gene transcription through the mediator complex su... | [
2003,
2004,
2008,
2007
] | 4 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
3870
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
5,
1,
1,
3,
2,
4,
1,
2,
3,
1,
15
] | 11 | true | Domain | Mediator complex, subunit Med13, N-terminal | Mediator complex, subunit Med13, N-terminal | Mediator_Med13_N | 4 |
IPR021644 | 21,644 | Chromatin assembly factor 1 p150 subunit, acidic region | CAF-1_p150_acidic | Domain | 1,951 | false | false | This entry represents the acidic region of CAF-1 p150 subunit which constitutes part of the histone binding interface [ ]. Chromatin assembly factor 1 (CAF-1) consists of three evolutionary conserved subunits, p150, p60, and p48 (yeast homologues Cac1, cac2 and cac3 respectively), and mediates the assembly of nucleosom... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF11600"
] | [
"CAF1A_acidic"
] | [
1951
] | 1 | [] | [] | [] | 0 | [
"7y5k",
"7y5l",
"7y5o",
"7y5u",
"7y5v",
"7y60",
"7y61",
"8iqf",
"8iqg",
"8j6s",
"8j6t"
] | 11 | [
"PUB00037579",
"PUB00066770",
"PUB00069802",
"PUB00094490",
"PUB00094491"
] | [
"14765118",
"12697822",
"21209461",
"31586391",
"28315523"
] | [
"Structural basis of HP1/PXVXL motif peptide interactions and HP1 localisation to heterochromatin.",
"The methyl-CpG binding protein MBD1 interacts with the p150 subunit of chromatin assembly factor 1.",
"An analysis of CAF-1-interacting proteins reveals dynamic and direct interactions with the KU complex and 1... | [
2004,
2003,
2011,
2019,
2017
] | 5 | [] | [] | 0 | 0 | null | [
"Bacillati",
"Eukaryota"
] | [
5,
1946
] | 2 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)"
] | [
3,
2,
2,
2,
1,
3,
1
] | 7 | true | Domain | Chromatin assembly factor 1 p150 subunit, acidic region | Chromatin assembly factor 1 p150 subunit, acidic region | CAF-1_p150_acidic | 7 |
IPR021645 | 21,645 | Shal-type voltage-gated potassium channels, N-terminal | Shal-type_N | Domain | 4,485 | false | false | This entry represents the N-terminal helical region of the Shal-type voltage-gated potassium channels. This domain interact with Kv channel-interacting proteins to modulate cell surface expression and function of Kv4 channels. The interaction of the Shal-type protein Kv4.2 and the Kv interacting protein KChiP1 forms a ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF11601"
] | [
"Shal-type"
] | [
4485
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-1296072",
"R-BTA-5576894",
"R-DME-1296072",
"R-DME-5576894",
"R-HSA-1296072",
"R-HSA-5576894",
"R-MMU-1296072",
"R-MMU-5576894",
"R-RNO-1296072",
"R-RNO-5576894"
] | [
"REACTOME:R-BTA-1296072",
"REACTOME:R-BTA-5576894",
"REACTOME:R-DME-1296072",
"REACTOME:R-DME-5576894",
"REACTOME:R-HSA-1296072",
"REACTOME:R-HSA-5576894",
"REACTOME:R-MMU-1296072",
"REACTOME:R-MMU-5576894",
"REACTOME:R-RNO-1296072",
"REACTOME:R-RNO-5576894"
] | 10 | [
"1b4g",
"1b4i",
"1s6c",
"1ztn",
"2i2r",
"2nz0",
"7e83",
"7e84",
"7e8e",
"7e8h",
"7f0j",
"7f3f",
"7uk5",
"7ukc",
"7ukd",
"7uke",
"7ukf",
"7ukg",
"7ukh",
"7w3y",
"7w6n",
"7w6s",
"7w6t"
] | 23 | [
"PUB00030933"
] | [
"14980206"
] | [
"Structural insights into the functional interaction of KChIP1 with Shal-type K(+) channels."
] | [
2004
] | 1 | [] | [] | 0 | 0 | null | [
"Eumetazoa",
"Sphaerobacter thermophilus (strain ATCC 49802 / DSM 20745 / KCCM 41009 / NCIMB 13125 / S 6022)"
] | [
4484,
1
] | 2 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
12,
2,
8,
8,
12
] | 6 | true | Domain | Shal-type voltage-gated potassium channels, N-terminal | Shal-type voltage-gated potassium channels, N-terminal | Shal-type_N | 7 |
IPR021646 | 21,646 | Sir1, ORC-binding domain | Sir1_ORC-binding | Domain | 174 | false | false | This entry represents the ORC-binding domain of Sir1. Sir1 interacts with the BAH domain of the Orc1 subunit of the origin recognition complex (ORC) resulting in the establishment of silent chromatin at HMR and HML in S.cerevisiae [ ]. The amino acids from the ORC interaction region of Sir1 are presented on a conserved... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF11603"
] | [
"Sir1"
] | [
174
] | 1 | [
"REACTOME",
"REACTOME"
] | [
"R-SCE-5689880",
"R-SCE-936440"
] | [
"REACTOME:R-SCE-5689880",
"REACTOME:R-SCE-936440"
] | 2 | [
"1z1a",
"1zbx",
"1zhi"
] | 3 | [
"PUB00038704",
"PUB00075493"
] | [
"15932939",
"9837911"
] | [
"Structural basis of the Sir1-origin recognition complex interaction in transcriptional silencing.",
"Y'-Help1, a DNA helicase encoded by the yeast subtelomeric Y' element, is induced in survivors defective for telomerase."
] | [
2005,
1998
] | 2 | [] | [] | 0 | 0 | null | [
"Rothia dentocariosa",
"Saccharomycotina"
] | [
1,
173
] | 2 | [
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)"
] | [
19
] | 1 | true | Domain | Sir1, ORC-binding domain | Sir1, ORC-binding domain | Sir1_ORC-binding | 2 |
IPR021647 | 21,647 | Copper binding periplasmic protein CusF | CusF_Ec | Family | 7,342 | false | false | CusF is a periplasmic protein involved in copper and silver resistance in Escherichia coil. CusF forms a five-stranded β-barrel OB fold. Cu(I) binds to H36, M47 and M49 which are conserved residues in the protein [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF11604"
] | [
"CusF_Ec"
] | [
7342
] | 1 | [
"GP"
] | [
"GenProp1168"
] | [
"GP:GenProp1168"
] | 1 | [
"1zeq",
"2l55",
"2qcp",
"2vb2",
"2vb3",
"3e6z",
"8bbz",
"8bhu",
"8bwv",
"8bxj",
"8c2q"
] | 11 | [
"PUB00038862"
] | [
"16060662"
] | [
"A novel copper-binding fold for the periplasmic copper resistance protein CusF."
] | [
2005
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
7234,
13,
95
] | 3 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Copper binding periplasmic protein CusF | Copper binding periplasmic protein CusF | CusF_Ec | 4 |
IPR021648 | 21,648 | Vacuolar protein sorting protein 36, GLUE domain | GLUE_dom | Domain | 4,876 | false | false | Vps36 is a subunit of ESCRT-II, a protein complex involved in driving protein sorting from endosomes to lysosomes. The GLUE domain of Vps36 allows for a tight interaction to occur between the protein and Vps28, a subunit of ESCRT-I. This interaction is critical for ubiquitinated cargo progression from early to late end... | [
"GO:0032266",
"GO:0043130"
] | [
"phosphatidylinositol-3-phosphate binding",
"ubiquitin binding"
] | [
"molecular_function",
"molecular_function"
] | 2 | [
"PFAM",
"PROFILE"
] | [
"PF11605",
"PS51495"
] | [
"Vps36_ESCRT-II",
"GLUE"
] | [
4275,
4361
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-DDI-917729",
"R-DME-917729",
"R-DRE-917729",
"R-HSA-917729",
"R-HSA-9610379",
"R-MMU-917729",
"R-RNO-917729",
"R-SCE-917729",
"R-SPO-917729"
] | [
"REACTOME:R-DDI-917729",
"REACTOME:R-DME-917729",
"REACTOME:R-DRE-917729",
"REACTOME:R-HSA-917729",
"REACTOME:R-HSA-9610379",
"REACTOME:R-MMU-917729",
"REACTOME:R-RNO-917729",
"REACTOME:R-SCE-917729",
"REACTOME:R-SPO-917729"
] | 9 | [
"1w7p",
"2cay",
"2dx5",
"2hth"
] | 4 | [
"PUB00039953",
"PUB00040336",
"PUB00057959",
"PUB00057960",
"PUB00057961"
] | [
"16615893",
"17057714",
"15755741",
"16615903",
"17034365"
] | [
"ESCRT-I core and ESCRT-II GLUE domain structures reveal role for GLUE in linking to ESCRT-I and membranes.",
"Structural basis of ubiquitin recognition by mammalian Eap45 GLUE domain.",
"Eap45 in mammalian ESCRT-II binds ubiquitin via a phosphoinositide-interacting GLUE domain.",
"ESCRT complexes assembled a... | [
2006,
2006,
2005,
2006,
2006
] | 5 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Candidatus Methanomethylicus mesodigestus",
"Eukaryota"
] | [
11,
1,
4864
] | 3 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
2,
1,
4,
1,
2,
3,
1,
2,
3,
1,
1,
10
] | 12 | true | Domain | Vacuolar protein sorting protein 36, GLUE domain | Vacuolar protein sorting protein 36, GLUE domain | GLUE_dom | 3 |
IPR021649 | 21,649 | Protein of unknown function DUF3247 | DUF3247 | Family | 285 | false | false | This family of proteins is the protein product of the gene XC5848 from Xanthomonas campestris. The protein has no known function however its structure has been determined. The protein adopts a Lsm fold however differences with the fold were observed at the N-terminal and internal regions [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF11607"
] | [
"DUF3247"
] | [
285
] | 1 | [] | [] | [] | 0 | [
"2e12"
] | 1 | [
"PUB00047306"
] | [
"17546661"
] | [
"XC5848, an ORFan protein from Xanthomonas campestris, adopts a novel variant of Sm-like motif."
] | [
2007
] | 1 | [] | [] | 0 | 0 | null | [
"Lysobacterales",
"Opisthokonta"
] | [
283,
2
] | 2 | [] | [] | 0 | true | Family | Protein of unknown function DUF3247 | Protein of unknown function DUF3247 | DUF3247 | 1 |
IPR021650 | 21,650 | Protein of unknown function DUF3248 | DUF3248 | Family | 119 | false | false | This family of proteins is thought to be the product of the gene TT1592 from Thermus thermophilus however this cannot be confirmed. Currently there is no known function. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF11609"
] | [
"DUF3248"
] | [
119
] | 1 | [] | [] | [] | 0 | [
"2e6x"
] | 1 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Deinococci"
] | [
119
] | 1 | [] | [] | 0 | true | Family | Protein of unknown function DUF3248 | Protein of unknown function DUF3248 | DUF3248 | 9 |
IPR021651 | 21,651 | Scaffold protein Ste5, Fus3-binding domain | Ste5_Fus-binding | Domain | 19 | false | false | This entry represents the Fus3 binding domain of Ste5. Ste5 functions in the yeast mating pathway and is required for signalling through the mating response MAPK pathway. Ste5 has separate binding sites for each member of the MAPK cascade. This region of Ste5 allosterically activates autophosphroylation of Fus3, a mito... | [
"GO:0019900"
] | [
"kinase binding"
] | [
"molecular_function"
] | 1 | [
"PFAM"
] | [
"PF11610"
] | [
"Ste5"
] | [
19
] | 1 | [] | [] | [] | 0 | [
"2f49"
] | 1 | [
"PUB00040531"
] | [
"16424299"
] | [
"The Ste5 scaffold allosterically modulates signaling output of the yeast mating pathway."
] | [
2006
] | 1 | [] | [] | 0 | 0 | null | [
"Saccharomyces"
] | [
19
] | 1 | [
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)"
] | [
1
] | 1 | true | Domain | Scaffold protein Ste5, Fus3-binding domain | Scaffold protein Ste5, Fus3-binding domain | Ste5_Fus-binding | 7 |
IPR021653 | 21,653 | CCR4-associated factor 4 | Caf4 | Family | 25 | false | false | Caf4 is a WD40 repeats containing protein involved in mitochondrial fission. It displays physical interactions with CCR4-NOT complex [ ]. It has a paralogue, Mdv1. Both Caf4 and Mdv1 act as adapter proteins, binding to Fis1 on the mitochondrial outer membrane and recruiting the dynamin-like GTPase Dnm1 to form mitochon... | [
"GO:0000266",
"GO:0005739"
] | [
"mitochondrial fission",
"mitochondrion"
] | [
"biological_process",
"cellular_component"
] | 2 | [
"PFAM"
] | [
"PF11615"
] | [
"Caf4"
] | [
25
] | 1 | [] | [] | [] | 0 | [
"2pqr"
] | 1 | [
"PUB00053320",
"PUB00053527",
"PUB00074937"
] | [
"16009724",
"11113136",
"16835275"
] | [
"The WD40 protein Caf4p is a component of the mitochondrial fission machinery and recruits Dnm1p to mitochondria.",
"Characterization of CAF4 and CAF16 reveals a functional connection between the CCR4-NOT complex and a subset of SRB proteins of the RNA polymerase II holoenzyme.",
"Fis1p and Caf4p, but not Mdv1p... | [
2005,
2001,
2006
] | 3 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
25
] | 1 | [
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)"
] | [
1
] | 1 | true | Family | CCR4-associated factor 4 | CCR4-associated factor 4 | Caf4 | 9 |
IPR021654 | 21,654 | Histone-lysine N-methyltransferase EZH1/EZH2, N-terminal | EZH1/EZH2_N | Domain | 3,134 | false | false | The Polycomb Repressive Complex 2 (PRC2) is a chromatin modifying complex that consists of three core components: EED, SUZ12 and one of the two histone H3K27 methyltransferases, EZH1 or EZH2 [ ]. The PRC2 complex catalyses di- and trimethylation of histone H3 lysine 27 (H3K37me2/3), which has a repressive role. Even th... | [
"GO:0046976"
] | [
"histone H3K27 methyltransferase activity"
] | [
"molecular_function"
] | 1 | [
"PFAM"
] | [
"PF11616"
] | [
"EZH2_WD-Binding"
] | [
3134
] | 1 | [
"EC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"2.1.1.356",
"R-DRE-212300",
"R-DRE-2559580",
"R-DRE-9764725",
"R-HSA-212300",
"R-HSA-2559580",
"R-HSA-3214841",
"R-HSA-5617472",
"R-HSA-8943724",
"R-HSA-8953750",
"R-HSA-9609690",
"R-HSA-9710421",
"R-HSA-9764725",
"R-MMU-212300",
"R-MMU-2559580",
"R-MMU-3214841",
"R-MMU-8953750",
... | [
"EC:2.1.1.356",
"REACTOME:R-DRE-212300",
"REACTOME:R-DRE-2559580",
"REACTOME:R-DRE-9764725",
"REACTOME:R-HSA-212300",
"REACTOME:R-HSA-2559580",
"REACTOME:R-HSA-3214841",
"REACTOME:R-HSA-5617472",
"REACTOME:R-HSA-8943724",
"REACTOME:R-HSA-8953750",
"REACTOME:R-HSA-9609690",
"REACTOME:R-HSA-9710... | 22 | [
"2qxv",
"4w2r",
"5gsa",
"5h14",
"5h15",
"5h17",
"5h19",
"5h24",
"5h25",
"5hyn",
"5ij7",
"5ij8",
"5ls6",
"5u5t",
"5u62",
"5wg6",
"5wuk",
"6b3w",
"6c23",
"6c24",
"6lo2",
"6u4y",
"6wkr",
"7at8",
"7kso",
"7ksr",
"7ktp",
"7qjg",
"7qju",
"7qk4",
"7td5",
"8eqv"... | 42 | [
"PUB00077180",
"PUB00077181"
] | [
"24951427",
"19026781"
] | [
"The polycomb repressive complex 2 governs life and death of peripheral T cells.",
"Ezh1 and Ezh2 maintain repressive chromatin through different mechanisms."
] | [
2014,
2008
] | 2 | [] | [] | 0 | 0 | null | [
"Vertebrata"
] | [
3134
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
18,
11,
7
] | 4 | true | Domain | Histone-lysine N-methyltransferase EZH1/EZH2, N-terminal | Histone-lysine N-methyltransferase EZH1/EZH2, N-terminal | EZH1/EZH2_N | 9 |
IPR021655 | 21,655 | Putative metal-binding motif | Put_metal-bd | Repeat | 1,899 | false | false | The presence of conserved cysteine residues and the lack of hydrophobic residues suggests that this repeat might be a metal-binding site, perhaps for zinc or calcium ions. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF11617"
] | [
"Cu-binding_MopE"
] | [
1899
] | 1 | [] | [] | [] | 0 | [
"2vov",
"2vow",
"2vox"
] | 3 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
54,
1735,
76,
34
] | 4 | [] | [] | 0 | true | Repeat | Putative metal-binding motif | Putative metal-binding motif | Put_metal-bd | 2 |
IPR021656 | 21,656 | RPGR-interacting protein 1, first C2 domain | C2-C2_1 | Domain | 2,232 | false | false | This domain is the first, more N-terminal, C2 domain on X-linked retinitis pigmentosa GTPase regulator-interacting proteins, or RPGR-interacting proteins [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF11618"
] | [
"C2-C2_1"
] | [
2232
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-5610787",
"R-HSA-5620912",
"R-MMU-5610787",
"R-MMU-5620912"
] | [
"REACTOME:R-HSA-5610787",
"REACTOME:R-HSA-5620912",
"REACTOME:R-MMU-5610787",
"REACTOME:R-MMU-5620912"
] | 4 | [
"2yrb"
] | 1 | [
"PUB00074742"
] | [
"17558409"
] | [
"The ciliary gene RPGRIP1L is mutated in cerebello-oculo-renal syndrome (Joubert syndrome type B) and Meckel syndrome."
] | [
2007
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
2232
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
13,
12,
4,
8
] | 5 | true | Domain | RPGR-interacting protein 1, first C2 domain | RPGR-interacting protein 1, first C2 domain | C2-C2_1 | 1 |
IPR021657 | 21,657 | Immunoglobulin-binding protein Sbi, domain IV | IgG-binding_Sbi_dom_IV | Domain | 63 | false | false | This entry represents domain IV of the immunoglobulin-binding protein Sbi from Staphylococcus aureus, which binds the central complement protein C3. Sbi-IV interacts with Sbi-III to induce a consumption of complement via alternative pathway activation [ ]. When not interacting with Sbi-III, Sbi-IV inhibits the alternat... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF11621"
] | [
"Sbi-IV"
] | [
63
] | 1 | [] | [] | [] | 0 | [
"2jvg",
"2jvh",
"2wy7",
"2wy8",
"6rmu"
] | 5 | [
"PUB00053528"
] | [
"18550524"
] | [
"Structure-function analysis of the C3 binding region of Staphylococcus aureus immune subversion protein Sbi."
] | [
2008
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria"
] | [
63
] | 1 | [] | [] | 0 | true | Domain | Immunoglobulin-binding protein Sbi, domain IV | Immunoglobulin-binding protein Sbi, domain IV | IgG-binding_Sbi_dom_IV | 3 |
IPR021658 | 21,658 | Domain of unknown function DUF3251 | DUF3251 | Domain | 1,200 | false | false | This entry represents a domain found in a group of bacterial lipoproteins, such as SadB from Salmonella typhimurium. SadB is required for proper surface expression of the autotransporter adhesin SadA [ ]. | [] | [] | [] | 0 | [
"NCBIFAM",
"PFAM"
] | [
"NF008575",
"PF11622"
] | [
"PRK11530.1",
"DUF3251"
] | [
1140,
1200
] | 2 | [] | [] | [] | 0 | [
"2jwy"
] | 1 | [
"PUB00086613"
] | [
"24369174"
] | [
"A trimeric lipoprotein assists in trimeric autotransporter biogenesis in enterobacteria."
] | [
2014
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Pseudomonadati",
"human gut metagenome"
] | [
2,
1197,
1
] | 3 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Domain | Domain of unknown function DUF3251 | Domain of unknown function DUF3251 | DUF3251 | 9 |
IPR021659 | 21,659 | NADH dehydrogenase-like complex, subunit S | NdhS | Family | 973 | false | false | NdhS/CRR31 (chlororespiratory reduction 31) is a subunit of the chloroplast NADH dehydrogenase-like (NDH) complex [ ]. It is also a subunit of the cyanobacterial NDH-1 complex [ , ]. NAD(P)H-oxidizing subunits have not been found in chloroplasts or cyanobacteria, where ferredoxin is probably the electron donor. NdhS co... | [
"GO:0009767"
] | [
"photosynthetic electron transport chain"
] | [
"biological_process"
] | 1 | [
"PFAM",
"PANTHER"
] | [
"PF11623",
"PTHR35494"
] | [
"NdhS",
""
] | [
886,
962
] | 2 | [] | [] | [] | 0 | [
"2jz2",
"3c4s",
"6a7k",
"6hum",
"6khi",
"6khj",
"6l7o",
"6l7p",
"6nbq",
"6nbx",
"6nby",
"6tjv"
] | 12 | [
"PUB00083363",
"PUB00083364",
"PUB00083365",
"PUB00083366",
"PUB00083367",
"PUB00083368"
] | [
"21505067",
"21785130",
"25630976",
"21880717",
"21035426",
"24225949"
] | [
"An Src homology 3 domain-like fold protein forms a ferredoxin binding site for the chloroplast NADH dehydrogenase-like complex in Arabidopsis.",
"Structure of the chloroplast NADH dehydrogenase-like complex: nomenclature for nuclear-encoded subunits.",
"NDH-1L interacts with ferredoxin via the subunit NdhS in ... | [
2011,
2011,
2015,
2011,
2011,
2013
] | 6 | [] | [] | 0 | 0 | null | [
"Cyanobacteriota",
"Eurybiavirus",
"Viridiplantae"
] | [
362,
2,
609
] | 3 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
3,
2,
2
] | 3 | true | Family | NADH dehydrogenase-like complex, subunit S | NADH dehydrogenase-like complex, subunit S | NdhS | 3 |
IPR021660 | 21,660 | Protein of unknown function DUF3253 | DUF3253 | Family | 2,488 | false | false | This bacterial family of proteins has no known function. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF11625"
] | [
"DUF3253"
] | [
2488
] | 1 | [] | [] | [] | 0 | [
"2ns0"
] | 1 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
2165,
304,
19
] | 3 | [] | [] | 0 | true | Family | Protein of unknown function DUF3253 | Protein of unknown function DUF3253 | DUF3253 | 4 |
IPR021661 | 21,661 | TRF2-interacting telomeric protein/Rap1, C-terminal | Rap1_C | Domain | 1,952 | false | false | This family of proteins represents the C-terminal domain of the protein Rap-1, which plays a distinct role in silencing at the silent mating-type loci and telomeres [ ]. The Rap-1 C terminus adopts an all-helical fold. Rap1 carries out its function by recruiting the Sir3 and Sir4 proteins to chromatin via its C-termina... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF11626"
] | [
"Rap1_C"
] | [
1952
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-110330",
"R-BTA-110331",
"R-BTA-171306",
"R-BTA-171319",
"R-BTA-174411",
"R-BTA-174414",
"R-BTA-174417",
"R-BTA-174430",
"R-BTA-174437",
"R-BTA-2559586",
"R-BTA-9670095",
"R-GGA-418124",
"R-HSA-110328",
"R-HSA-110329",
"R-HSA-110330",
"R-HSA-110331",
"R-HSA-1221632",
"R-HSA-... | [
"REACTOME:R-BTA-110330",
"REACTOME:R-BTA-110331",
"REACTOME:R-BTA-171306",
"REACTOME:R-BTA-171319",
"REACTOME:R-BTA-174411",
"REACTOME:R-BTA-174414",
"REACTOME:R-BTA-174417",
"REACTOME:R-BTA-174430",
"REACTOME:R-BTA-174437",
"REACTOME:R-BTA-2559586",
"REACTOME:R-BTA-9670095",
"REACTOME:R-GGA-4... | 51 | [
"3cz6",
"3k6g",
"3owt",
"4bj5",
"4bj6",
"4bjt",
"8rd4"
] | 7 | [
"PUB00033335",
"PUB00051186",
"PUB00066683",
"PUB00066684",
"PUB00066685"
] | [
"15316005",
"18538788",
"16166375",
"20339076",
"20622869"
] | [
"TIN2 binds TRF1 and TRF2 simultaneously and stabilizes the TRF2 complex on telomeres.",
"Structural and functional studies of the Rap1 C-terminus reveal novel separation-of-function mutants.",
"Shelterin: the protein complex that shapes and safeguards human telomeres.",
"Loss of Rap1 induces telomere recombi... | [
2004,
2008,
2005,
2010,
2010
] | 5 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1952
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)"
] | [
12,
1,
1,
1,
3,
1
] | 6 | true | Domain | TRF2-interacting telomeric protein/Rap1, C-terminal | TRF2-interacting telomeric protein/Rap1, C-terminal | Rap1_C | 1 |
IPR021662 | 21,662 | Heterogeneous nuclear ribonucleoprotein A1/A2, C-terminal | HnRNPA1/A2_C | Domain | 2,672 | false | false | This entry includes the heterogeneous nuclear ribonucleoprotein A1 (hnRNPA1), a nuclear factor that binds to Pol II transcripts. The family of hnRNP proteins is involved in numerous RNA-related activities [ ]. hnRNPA1 is involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucl... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF11627"
] | [
"HnRNPA1_LC"
] | [
2672
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-6803529",
"R-BTA-72163",
"R-BTA-72203",
"R-HSA-6803529",
"R-HSA-72163",
"R-HSA-72203",
"R-HSA-8950505",
"R-HSA-9692914",
"R-HSA-9735869",
"R-MMU-6803529",
"R-MMU-72163",
"R-MMU-72203",
"R-RNO-6803529",
"R-RNO-72163",
"R-RNO-72203"
] | [
"REACTOME:R-BTA-6803529",
"REACTOME:R-BTA-72163",
"REACTOME:R-BTA-72203",
"REACTOME:R-HSA-6803529",
"REACTOME:R-HSA-72163",
"REACTOME:R-HSA-72203",
"REACTOME:R-HSA-8950505",
"REACTOME:R-HSA-9692914",
"REACTOME:R-HSA-9735869",
"REACTOME:R-MMU-6803529",
"REACTOME:R-MMU-72163",
"REACTOME:R-MMU-72... | 15 | [
"2h4m",
"6wqk",
"7bx7",
"7zj2",
"8du2",
"8duw",
"8ec7",
"9gkf"
] | 8 | [
"PUB00053529",
"PUB00100352",
"PUB00100353",
"PUB00100354",
"PUB00100600",
"PUB00101194"
] | [
"15776420",
"20010808",
"17371836",
"31498791",
"33311513",
"23455423"
] | [
"HnRNP A3 genes and pseudogenes in the vertebrate genomes.",
"HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer.",
"The RNA-binding protein Sam68 modulates the alternative splicing of Bcl-x.",
"EV71 3C protease induces apoptosis by cleavage of hnRNP A1 to promote apaf-1 tra... | [
2005,
2010,
2007,
2019,
2020,
2013
] | 6 | [] | [] | 0 | 0 | null | [
"Bilateria"
] | [
2672
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
50,
14,
20
] | 3 | true | Domain | Heterogeneous nuclear ribonucleoprotein A1/A2, C-terminal | Heterogeneous nuclear ribonucleoprotein A1/A2, C-terminal | HnRNPA1/A2_C | 4 |
IPR021663 | 21,663 | T-cell surface glycoprotein CD3 zeta subunit/High affinity IgE receptor gamma subunit | CD3_zeta/IgE_Fc_rcpt_gamma | Family | 1,591 | false | false | The TCR complex of T-lymphocytes consists of either a TCR alpha/beta or TCR gamma/delta heterodimer co-expressed at the cell surface with the invariant subunits of CD3 labelled gamma, delta, epsilon, zeta, and eta [ ]. The zeta subunit forms either homodimers or heterodimers with eta [ ], but eta homodimers have not be... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF11628"
] | [
"TCR_zetazeta"
] | [
1591
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-114604",
"R-BTA-202733",
"R-BTA-2454202",
"R-BTA-2730905",
"R-BTA-2871796",
"R-BTA-2871809",
"R-BTA-2871837",
"R-BTA-5621480",
"R-BTA-6798695",
"R-BTA-75892",
"R-HSA-114604",
"R-HSA-164944",
"R-HSA-198933",
"R-HSA-202424",
"R-HSA-202427",
"R-HSA-202430",
"R-HSA-202433",
"R-H... | [
"REACTOME:R-BTA-114604",
"REACTOME:R-BTA-202733",
"REACTOME:R-BTA-2454202",
"REACTOME:R-BTA-2730905",
"REACTOME:R-BTA-2871796",
"REACTOME:R-BTA-2871809",
"REACTOME:R-BTA-2871837",
"REACTOME:R-BTA-5621480",
"REACTOME:R-BTA-6798695",
"REACTOME:R-BTA-75892",
"REACTOME:R-HSA-114604",
"REACTOME:R-H... | 71 | [
"2hac",
"6jxr",
"7fjd",
"7fje",
"7fjf",
"7phr",
"8es7",
"8es8",
"8es9",
"8j8i",
"8jc0",
"8jcb",
"8k7t",
"8tw4",
"8tw6",
"8wxe",
"8wy0",
"8wyi",
"8y81",
"8y84",
"8yc0",
"8yrj",
"8yvu",
"8ywa",
"8za6",
"8zgs",
"8zgt",
"9bbc",
"9c3e",
"9ci8",
"9cia",
"9cq4"... | 35 | [
"PUB00041339",
"PUB00055464",
"PUB00055465",
"PUB00055466",
"PUB00055467"
] | [
"17055436",
"9072162",
"8112294",
"8611682",
"1714902"
] | [
"The structure of the zetazeta transmembrane dimer reveals features essential for its assembly with the T cell receptor.",
"T-cell receptors: feeling out the complex.",
"Targeted disruption within the CD3 zeta/eta/phi/Oct-1 locus in mouse.",
"FcR gamma-chain is essential for both surface expression and functi... | [
2006,
1997,
1994,
1996,
1991
] | 5 | [] | [
"IPR024128",
"IPR042340"
] | 0 | 2 | 0 | [
"Gnathostomata",
"bird metagenome"
] | [
1590,
1
] | 2 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
5,
13,
6,
12
] | 4 | true | Family | T-cell surface glycoprotein CD3 zeta subunit/High affinity IgE receptor gamma subunit | T-cell surface glycoprotein CD3 zeta subunit/High affinity IgE receptor gamma subunit | CD3_zeta/IgE_Fc_rcpt_gamma | 1 |
IPR021664 | 21,664 | Protein of unknown function DUF3255 | DUF3255 | Family | 33 | false | false | Members in this family of proteins are annotated as YxeF however no function is currently known. The family appears to be restricted to Bacillus. | [] | [] | [] | 0 | [
"PFAM",
"CDD"
] | [
"PF11631",
"cd19434"
] | [
"DUF3255",
"lipocalin_YxeF"
] | [
33,
31
] | 2 | [] | [] | [] | 0 | [
"2joz"
] | 1 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacillaceae"
] | [
33
] | 1 | [] | [] | 0 | true | Family | Protein of unknown function DUF3255 | Protein of unknown function DUF3255 | DUF3255 | 7 |
IPR021665 | 21,665 | Mediator complex, subunit Med16, N-terminal | Mediator_Med16_N | Domain | 2,844 | false | false | This entry represents the N-terminal β-propeller domain of human Mediator of RNA polymerase II transcription subunit 16 (MED16) and similar proteins from fungi and animals [ ]. Mediator is a large complex of up to 33 proteins that is conserved from plants through fungi to humans - the number and representation of indiv... | [
"GO:0016592"
] | [
"mediator complex"
] | [
"cellular_component"
] | 1 | [
"PFAM"
] | [
"PF11635"
] | [
"Med16_N"
] | [
2844
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-DME-9841922",
"R-HSA-1989781",
"R-HSA-212436",
"R-HSA-381340",
"R-HSA-9833110",
"R-HSA-9841922"
] | [
"REACTOME:R-DME-9841922",
"REACTOME:R-HSA-1989781",
"REACTOME:R-HSA-212436",
"REACTOME:R-HSA-381340",
"REACTOME:R-HSA-9833110",
"REACTOME:R-HSA-9841922"
] | 6 | [
"6w1s",
"7emf",
"7ena",
"7enc",
"7enj",
"7jmn",
"7lbm",
"7uic",
"7uik",
"7uil",
"7uio",
"8gxq",
"8gxs",
"8t1i",
"8t1l",
"8t9d",
"8tqw",
"8trh"
] | 18 | [
"PUB00033372",
"PUB00053521",
"PUB00053530",
"PUB00151584"
] | [
"15175151",
"15175163",
"15297616",
"33958484"
] | [
"A unified nomenclature for protein subunits of mediator complexes linking transcriptional regulators to RNA polymerase II.",
"A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology.",
"MED16 and MED23 of Mediator are coactivators of lipopolysaccharide- a... | [
2004,
2004,
2004,
2021
] | 4 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
2844
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)"
] | [
2,
1,
8,
7,
1,
5,
1
] | 7 | true | Domain | Mediator complex, subunit Med16, N-terminal | Mediator complex, subunit Med16, N-terminal | Mediator_Med16_N | 9 |
IPR021666 | 21,666 | Troponin I residues 1-32 | Troponin-I_N | Family | 243 | false | false | This family of proteins represents the cardiac N-extension of troponin I. This region of the protein (1-32) interacts with the N-lobe of cTnC and modulates myofilament calcium(2) sensitivity [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF11636"
] | [
"Troponin-I_N"
] | [
243
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-CFA-390522",
"R-CFA-5578775",
"R-HSA-390522",
"R-HSA-5578775",
"R-MMU-390522",
"R-MMU-5578775",
"R-RNO-390522",
"R-RNO-5578775"
] | [
"REACTOME:R-CFA-390522",
"REACTOME:R-CFA-5578775",
"REACTOME:R-HSA-390522",
"REACTOME:R-HSA-5578775",
"REACTOME:R-MMU-390522",
"REACTOME:R-MMU-5578775",
"REACTOME:R-RNO-390522",
"REACTOME:R-RNO-5578775"
] | 8 | [
"2jpw",
"4y99",
"7uti",
"7utl",
"8uww",
"8uwx",
"8uwy",
"8uyd",
"8uz5",
"8uz6",
"8uzx",
"8uzy",
"8v01",
"8v0i",
"8v0k",
"8v0y",
"9mo4",
"9mo5",
"9mo6",
"9mo7",
"9mo8",
"9mo9",
"9moa",
"9mob",
"9moc",
"9mod",
"9moi",
"9mok",
"9mol",
"9mom",
"9mon",
"9moo"... | 36 | [
"PUB00048030"
] | [
"17854829"
] | [
"Phosphorylation-dependent conformational transition of the cardiac specific N-extension of troponin I in cardiac troponin."
] | [
2007
] | 1 | [] | [] | 0 | 0 | null | [
"Polyangium spumosum",
"Tetrapoda",
"bird metagenome"
] | [
1,
241,
1
] | 3 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
8,
4,
1
] | 3 | true | Family | Troponin I residues 1-32 | Troponin I residues 1-32 | Troponin-I_N | 1 |
IPR021667 | 21,667 | REDY-like protein HapK | HapK | Family | 355 | false | false | This family of proteins represents HapK, a protein of unknown function, with two homologues PigK and RedY. The monomer structure of the protein contains a four-stranded anti parallel β-sheet, three α-helices and a short C-terminal tail which it uses for dimer formation [ ]. The surface of HapK has a deep cavity with co... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF11639"
] | [
"HapK"
] | [
355
] | 1 | [] | [] | [] | 0 | [
"2jdj"
] | 1 | [
"PUB00047880"
] | [
"17729271"
] | [
"Structural insight of the role of the Hahella chejuensis HapK protein in prodigiosin biosynthesis."
] | [
2008
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"ecological metagenomes"
] | [
349,
6
] | 2 | [] | [] | 0 | true | Family | REDY-like protein HapK | REDY-like protein HapK | HapK | 9 |
IPR021668 | 21,668 | Telomere-length maintenance and DNA damage repair | TAN | Domain | 2,908 | false | false | ATM is a large protein kinase, in humans, critical for responding to DNA double-strand breaks (DSBs). Tel1, the orthologue from budding yeast, also regulates responses to DSBs. Tel1 is important for maintaining viability and for phosphorylation of the DNA damage signal transducer kinase Rad53 (an orthologue of mammalia... | [
"GO:0004674"
] | [
"protein serine/threonine kinase activity"
] | [
"molecular_function"
] | 1 | [
"PFAM",
"SMART"
] | [
"PF11640",
"SM01342"
] | [
"TAN",
"TAN"
] | [
2830,
2832
] | 2 | [
"EC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
... | [
"2.7.11.1",
"R-HSA-2559586",
"R-HSA-3371453",
"R-HSA-349425",
"R-HSA-5685938",
"R-HSA-5685942",
"R-HSA-5693548",
"R-HSA-5693554",
"R-HSA-5693565",
"R-HSA-5693568",
"R-HSA-5693571",
"R-HSA-5693579",
"R-HSA-5693607",
"R-HSA-5693616",
"R-HSA-6796648",
"R-HSA-6803204",
"R-HSA-6803207",
... | [
"EC:2.7.11.1",
"REACTOME:R-HSA-2559586",
"REACTOME:R-HSA-3371453",
"REACTOME:R-HSA-349425",
"REACTOME:R-HSA-5685938",
"REACTOME:R-HSA-5685942",
"REACTOME:R-HSA-5693548",
"REACTOME:R-HSA-5693554",
"REACTOME:R-HSA-5693565",
"REACTOME:R-HSA-5693568",
"REACTOME:R-HSA-5693571",
"REACTOME:R-HSA-5693... | 58 | [
"5np0",
"5np1",
"6jxa",
"6jxc",
"6k9k",
"6k9l",
"6sky",
"6skz",
"6sl0",
"6sl1",
"7ni4",
"7ni5",
"7ni6",
"7sic",
"7sid",
"8oxm",
"8oxo",
"8oxp",
"8oxq",
"9iz0",
"9iz7"
] | 21 | [
"PUB00053531"
] | [
"18625723"
] | [
"A novel Tel1/ATM N-terminal motif, TAN, is essential for telomere length maintenance and a DNA damage response."
] | [
2008
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
2908
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
2,
16,
4,
1,
3,
1,
1
] | 7 | true | Domain | Telomere-length maintenance and DNA damage repair | Telomere-length maintenance and DNA damage repair | TAN | 4 |
IPR021669 | 21,669 | Bd37, core domain | Bd37_core | Domain | 41 | false | false | This entry represents the core domain of Bd37 (also known as Glycosylphosphatidylinositol-anchored merozoite surface protein), a surface antigen of B.divergens which is GPI-anchored at the surface of the merozoite. The structure of the protein consists of mainly α folds and has three sub domains [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF11641"
] | [
"Antigen_Bd37"
] | [
41
] | 1 | [] | [] | [] | 0 | [
"2jo7",
"2lud"
] | 2 | [
"PUB00047995"
] | [
"18035372"
] | [
"The solution structure of the adhesion protein Bd37 from Babesia divergens reveals structural homology with eukaryotic proteins involved in membrane trafficking."
] | [
2008
] | 1 | [] | [] | 0 | 0 | null | [
"Babesia"
] | [
41
] | 1 | [] | [] | 0 | true | Domain | Bd37, core domain | Bd37, core domain | Bd37_core | 9 |
IPR021670 | 21,670 | Protein of unknown function DUF3256 | DUF3256 | Family | 513 | false | false | This family of proteins with unknown function appears to be restricted to Bacteroidales. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF11644"
] | [
"DUF3256"
] | [
513
] | 1 | [] | [] | [] | 0 | [
"2p3p"
] | 1 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"metagenomes"
] | [
488,
25
] | 2 | [] | [] | 0 | true | Family | Protein of unknown function DUF3256 | Protein of unknown function DUF3256 | DUF3256 | 4 |
IPR021671 | 21,671 | PD(D/E)XK endonuclease | PD(D/E)XK_Endonuc | Domain | 700 | false | false | Proteins containing this domain are endonucleases, including group I intron-encoded endonuclease [ ]. They belong to the PD-(D/E)XK superfamily [ , ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF11645"
] | [
"PDDEXK_5"
] | [
700
] | 1 | [] | [] | [] | 0 | [
"2ost"
] | 1 | [
"PUB00042270",
"PUB00066698",
"PUB00066699"
] | [
"17410205",
"11251845",
"22638584"
] | [
"The restriction fold turns to the dark side: a bacterial homing endonuclease with a PD-(D/E)-XK motif.",
"A novel group I intron-encoded endonuclease specific for the anticodon region of tRNA(fMet) genes.",
"Sequence, structure and functional diversity of PD-(D/E)XK phosphodiesterase superfamily."
] | [
2007,
2001,
2012
] | 3 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Reticulomyxa filosa",
"Viruses",
"metagenomes"
] | [
191,
437,
1,
50,
21
] | 5 | [] | [] | 0 | true | Domain | PD(D/E)XK endonuclease | PD(D/E)XK endonuclease | PD(D/E)XK_Endonuc | 1 |
IPR021672 | 21,672 | Protein of unknown function DUF3258 | DUF3258 | Family | 13 | false | false | This protein family is found in virus and prophages from proteobacteria, including Uncharacterized protein ORF157 from Acidianus filamentous virus 1. This protein shows two antiparallel β-sheets formed by three and five strands in its N-terminal part and three helices towards the C-terminal, one of them roughly perpend... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF11646"
] | [
"DUF3258"
] | [
13
] | 1 | [] | [] | [] | 0 | [
"3ii2",
"3ii3",
"3ild",
"3ile",
"3vb8"
] | 5 | [
"PUB00054813"
] | [
"20200253"
] | [
"ORF157 from the archaeal virus Acidianus filamentous virus 1 defines a new class of nuclease."
] | [
2010
] | 1 | [] | [] | 0 | 0 | null | [
"Acidianus ambivalens",
"Gammaproteobacteria",
"Viruses"
] | [
1,
10,
2
] | 3 | [] | [] | 0 | true | Family | Protein of unknown function DUF3258 | Protein of unknown function DUF3258 | DUF3258 | 4 |
IPR021673 | 21,673 | RIG-I-like receptor, C-terminal regulatory domain | RLR_CTR | Domain | 4,262 | false | false | Intracellular RIG-I-like receptors (RLRs: retinoic acid-inducible gene I, RIG-I; melanoma differenciation-associated gene 5, MDA-5; and laboratory of genetics and physiology 2, LGP2) recognise viral RNAs as pathogen-associated molecular patterns (PAMPs) and initiate an antiviral immune response. RLRs belong to the supe... | [] | [] | [] | 0 | [
"PFAM",
"PROFILE"
] | [
"PF11648",
"PS51789"
] | [
"RIG-I_C-RD",
"RLR_CTR"
] | [
4169,
4218
] | 2 | [
"EC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"3.6.4.13",
"R-HSA-1169408",
"R-HSA-168928",
"R-HSA-5689880",
"R-HSA-5689896",
"R-HSA-8983711",
"R-HSA-918233",
"R-HSA-933541",
"R-HSA-933542",
"R-HSA-933543",
"R-HSA-936440",
"R-HSA-9692916",
"R-HSA-9705671",
"R-HSA-9833109",
"R-HSA-9833110",
"R-HSA-9909505",
"R-MMU-1169408",
"R-M... | [
"EC:3.6.4.13",
"REACTOME:R-HSA-1169408",
"REACTOME:R-HSA-168928",
"REACTOME:R-HSA-5689880",
"REACTOME:R-HSA-5689896",
"REACTOME:R-HSA-8983711",
"REACTOME:R-HSA-918233",
"REACTOME:R-HSA-933541",
"REACTOME:R-HSA-933542",
"REACTOME:R-HSA-933543",
"REACTOME:R-HSA-936440",
"REACTOME:R-HSA-9692916",... | 21 | [
"2qfb",
"2qfd",
"2rmj",
"2rqa",
"2rqb",
"2w4r",
"2ykg",
"3eqt",
"3ga3",
"3lrn",
"3lrr",
"3ncu",
"3og8",
"3zd6",
"3zd7",
"4a2v",
"4a2w",
"4a2x",
"4ay2",
"4bpb",
"4gl2",
"5e3h",
"5f98",
"5f9f",
"5f9h",
"5jaj",
"5jb2",
"5jbg",
"5jbj",
"5jc3",
"5jc7",
"5jcf"... | 78 | [
"PUB00048985",
"PUB00050038",
"PUB00057142",
"PUB00084296",
"PUB00084297",
"PUB00097473"
] | [
"18243112",
"19208642",
"22000018",
"24912143",
"25101084",
"20961956"
] | [
"The C-terminal regulatory domain is the RNA 5'-triphosphate sensor of RIG-I.",
"The regulatory domain of the RIG-I family ATPase LGP2 senses double-stranded RNA.",
"Structural insights into RNA recognition by RIG-I.",
"An evolving arsenal: viral RNA detection by RIG-I-like receptors.",
"Pattern Recognition... | [
2008,
2009,
2011,
2014,
2014,
2011
] | 6 | [] | [] | 0 | 0 | null | [
"Metazoa"
] | [
4262
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
4,
17,
9,
9
] | 5 | true | Domain | RIG-I-like receptor, C-terminal regulatory domain | RIG-I-like receptor, C-terminal regulatory domain | RLR_CTR | 2 |
IPR021674 | 21,674 | Bacteriophage T4, Gp14, neck protein | Phage_T4_Gp14_neck-protein | Family | 660 | false | false | This family of protein is represented by bacteriophage T4 Gp14, a major component of the neck along with Gp13. When added to completed heads, Gp13 and Gp14 structural proteins activate the heads for tail joining in vitro complementation mixtures. Gp14 is rich is β-sheets. The formation of the neck to the head of the ba... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF11649"
] | [
"T4_neck-protein"
] | [
660
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00053532"
] | [
"17602902"
] | [
"The neck of bacteriophage T4 is a ring-like structure formed by a hetero-oligomer of gp13 and gp14."
] | [
2007
] | 1 | [] | [] | 0 | 0 | null | [
"Marine Group I thaumarchaeote",
"Pseudomonadati",
"Viruses",
"marine metagenome"
] | [
4,
3,
611,
42
] | 4 | [] | [] | 0 | true | Family | Bacteriophage T4, Gp14, neck protein | Bacteriophage T4, Gp14, neck protein | Phage_T4_Gp14_neck-protein | 6 |
IPR021675 | 21,675 | Protein of unknown function DUF3261 | DUF3261 | Family | 1,674 | false | false | This family of proteins with unknown function appears to be restricted in general to Proteobacteria. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF11659"
] | [
"DUF3261"
] | [
1674
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Opisthokonta",
"metagenomes"
] | [
1655,
4,
15
] | 3 | [] | [] | 0 | true | Family | Protein of unknown function DUF3261 | Protein of unknown function DUF3261 | DUF3261 | 6 |
IPR021676 | 21,676 | Protein of unknown function DUF3262 | DUF3262 | Family | 1,625 | false | false | This entry represents small, hydrophobic proteins that are found occasionally on plasmids such as the Pseudomonas putida TOL (toluene catabolic) plasmid pWWO_p085. Usually, however, they are found on the bacterial main chromosome in regions flanked by markers of conjugative transfer and/or transposition. | [] | [] | [] | 0 | [
"PFAM",
"NCBIFAM"
] | [
"PF11660",
"TIGR03758"
] | [
"DUF3262",
"conj_TIGR03758"
] | [
1622,
1509
] | 2 | [
"GP"
] | [
"GenProp0855"
] | [
"GP:GenProp0855"
] | 1 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Gibberella intermedia",
"metagenomes"
] | [
1612,
1,
12
] | 3 | [] | [] | 0 | true | Family | Protein of unknown function DUF3262 | Protein of unknown function DUF3262 | DUF3262 | 3 |
IPR021677 | 21,677 | Protein of unknown function DUF2986 | DUF2986 | Family | 1,302 | false | false | This family of proteins has no known function. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF11661"
] | [
"DUF2986"
] | [
1302
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"ecological metagenomes"
] | [
1290,
9,
3
] | 3 | [] | [] | 0 | true | Family | Protein of unknown function DUF2986 | Protein of unknown function DUF2986 | DUF2986 | 1 |
IPR021678 | 21,678 | Protein of unknown function DUF3263 | DUF3263 | Family | 4,722 | false | false | This family of proteins with unknown function appears to be restricted to Actinobacteria. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF11662"
] | [
"DUF3263"
] | [
4722
] | 1 | [] | [] | [] | 0 | [
"9n2g",
"9n2n"
] | 2 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Caudoviricetes",
"Rhynchospora breviuscula",
"metagenomes"
] | [
4519,
81,
2,
120
] | 4 | [] | [] | 0 | true | Family | Protein of unknown function DUF3263 | Protein of unknown function DUF3263 | DUF3263 | 4 |
IPR021679 | 21,679 | Toxin endonuclease, YhaV | Toxin_endonuclease_YhaV | Family | 1,242 | false | false | YhaV causes reversible bacteriostasis and is part of a toxin-antitoxin system in Escherichia coli along with PrlF. The toxicity of YhaV is counteracted by PrlF by the formation of a tight complex which binds to the promoter of the prlF-yhaV operon. In vitro, YhaV also has endonuclease activity [ ]. | [
"GO:0004540",
"GO:0110001"
] | [
"RNA nuclease activity",
"toxin-antitoxin complex"
] | [
"molecular_function",
"cellular_component"
] | 2 | [
"PFAM"
] | [
"PF11663"
] | [
"Toxin_YhaV"
] | [
1242
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00053533"
] | [
"17706670"
] | [
"prlF and yhaV encode a new toxin-antitoxin system in Escherichia coli."
] | [
2007
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Drosophila rhopaloa",
"Vibrio phage O395",
"metagenomes"
] | [
1214,
1,
1,
26
] | 4 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Toxin endonuclease, YhaV | Toxin endonuclease, YhaV | Toxin_endonuclease_YhaV | 9 |
IPR021682 | 21,682 | Protein of unknown function DUF2933 | DUF2933 | Family | 2,418 | false | false | This bacterial family of proteins has no known function. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF11666"
] | [
"DUF2933"
] | [
2418
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
6,
2380,
4,
28
] | 4 | [] | [] | 0 | true | Family | Protein of unknown function DUF2933 | Protein of unknown function DUF2933 | DUF2933 | 3 |
IPR021683 | 21,683 | Putative zincin peptidase | DUF3267 | Family | 3,119 | false | false | This family of proteins has a conserved HEXXH motif, suggesting the members are putative peptidases of zincin fold [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF11667"
] | [
"DUF3267"
] | [
3119
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00075429"
] | [
"23671590"
] | [
"CLCAs - a family of metalloproteases of intriguing phylogenetic distribution and with cases of substituted catalytic sites."
] | [
2013
] | 1 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"metagenomes"
] | [
264,
2832,
23
] | 3 | [] | [] | 0 | true | Family | Putative zincin peptidase | Putative zincin peptidase | DUF3267 | 4 |
IPR021684 | 21,684 | WW domain-binding protein 1-like | WBP1-like | Family | 2,876 | false | false | This entry includes WBP-1 and its homologous. WBP-1 is a ligand of the WW domain of Yes-associated protein. This protein has a proline-rich domain. WBP-1 does not bind to the SH3 domain [ ]. This entry also includes transmembrane protein 92 (TMEM92), whose function is not clear. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF11669"
] | [
"WBP-1"
] | [
2876
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00001690"
] | [
"7641887"
] | [
"Characterization of a novel protein-binding module--the WW domain."
] | [
1995
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"bird metagenome"
] | [
2875,
1
] | 2 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
9,
9,
8,
15
] | 4 | true | Family | WW domain-binding protein 1-like | WW domain-binding protein 1-like | WBP1-like | 1 |
IPR021686 | 21,686 | Protein of unkown function DUF3268 | DUF3268 | Family | 942 | false | false | This is a family of bacterial and plasmid sequences that carry at least one zinc-finger towards the N terminus and a possible second at the C terminus. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF11672"
] | [
"DUF3268"
] | [
942
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Viruses",
"metagenomes"
] | [
722,
7,
193,
20
] | 4 | [] | [] | 0 | true | Family | Protein of unkown function DUF3268 | Protein of unkown function DUF3268 | DUF3268 | 8 |
IPR021687 | 21,687 | Protein of unknown function DUF3269 | DUF3269 | Family | 141 | false | false | This entry includes Bacteriophage 92, Orf70. The characteristics of the protein distribution suggest prophage matches in addition to the phage matches. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF11673"
] | [
"DUF3269"
] | [
141
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacillales",
"Caudoviricetes"
] | [
74,
67
] | 2 | [] | [] | 0 | true | Family | Protein of unknown function DUF3269 | Protein of unknown function DUF3269 | DUF3269 | 5 |
IPR021688 | 21,688 | Protein of unknown function DUF3270 | DUF3270 | Family | 469 | false | false | This family of proteins with unknown function appears to be restricted to Streptococcus. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF11674"
] | [
"DUF3270"
] | [
469
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria"
] | [
469
] | 1 | [] | [] | 0 | true | Family | Protein of unknown function DUF3270 | Protein of unknown function DUF3270 | DUF3270 | 3 |
IPR021689 | 21,689 | Protein of unknown function DUF3271 | DUF3271 | Family | 193 | false | false | This family of proteins with unknown function appears to be restricted to Plasmodium. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF11675"
] | [
"DUF3271"
] | [
193
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Plasmodium"
] | [
193
] | 1 | [] | [] | 0 | true | Family | Protein of unknown function DUF3271 | Protein of unknown function DUF3271 | DUF3271 | 4 |
IPR021690 | 21,690 | Protein of unknown function DUF3272 | DUF3272 | Family | 354 | false | false | This family of proteins with unknown function appears to be restricted to Streptococcus. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF11676"
] | [
"DUF3272"
] | [
354
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"human gut metagenome"
] | [
353,
1
] | 2 | [] | [] | 0 | true | Family | Protein of unknown function DUF3272 | Protein of unknown function DUF3272 | DUF3272 | 5 |
IPR021691 | 21,691 | Protein of unknown function DUF3273 | DUF3273 | Family | 408 | false | false | Some members in this family of proteins are annotated as multi-transmembrane proteins however this cannot be confirmed. Currently this family has no known function. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF11677"
] | [
"DUF3273"
] | [
408
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Alveolata"
] | [
408
] | 1 | [] | [] | 0 | true | Family | Protein of unknown function DUF3273 | Protein of unknown function DUF3273 | DUF3273 | 4 |
IPR021692 | 21,692 | Antibacterial effector protein Tle3, C-terminal | Tle3_C | Domain | 624 | false | false | This entry represents the C-terminal domain of Antibacterial effector protein Tle3 from Pseudomonas aeruginosa and similar sequences from proteobacteria. Tle3 is toxic once delivered in the periplasm of prey bacteria [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF11678"
] | [
"Tle3_C"
] | [
624
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00100136"
] | [
"31231326"
] | [
"A Type VI Secretion System Trans-Kingdom Effector Is Required for the Delivery of a Novel Antibacterial Toxin in <i>Pseudomonas aeruginosa</i>."
] | [
2019
] | 1 | [] | [] | 0 | 0 | null | [
"Pseudomonadota",
"Ralstonia phage RSY1",
"Ricinus communis",
"ecological metagenomes"
] | [
619,
1,
1,
3
] | 4 | [] | [] | 0 | true | Domain | Antibacterial effector protein Tle3, C-terminal | Antibacterial effector protein Tle3, C-terminal | Tle3_C | 5 |
IPR021693 | 21,693 | Protein of unknown function DUF3275 | DUF3275 | Family | 783 | false | false | This family of proteins with unknown function appear to be restricted to Proteobacteria. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF11679"
] | [
"DUF3275"
] | [
783
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
760,
4,
19
] | 3 | [] | [] | 0 | true | Family | Protein of unknown function DUF3275 | Protein of unknown function DUF3275 | DUF3275 | 9 |
IPR021696 | 21,696 | Domain of unknown function DUF3279 | DUF3279 | Domain | 851 | false | false | This domain is found in uncharacterised proteins with unknown function and appears to be restricted to Enterobacteriaceae. It is predicted to adopt a structure typical for zinc-ribbon domains. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF11682"
] | [
"Zn_ribbon_11"
] | [
851
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"metagenomes"
] | [
849,
2
] | 2 | [] | [] | 0 | true | Domain | Domain of unknown function DUF3279 | Domain of unknown function DUF3279 | DUF3279 | 9 |
IPR021697 | 21,697 | Protein of unknown function DUF3278 | DUF3278 | Family | 1,095 | false | false | This bacterial family of proteins has no known function. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF11683"
] | [
"DUF3278"
] | [
1095
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria"
] | [
1095
] | 1 | [] | [] | 0 | true | Family | Protein of unknown function DUF3278 | Protein of unknown function DUF3278 | DUF3278 | 3 |
IPR021698 | 21,698 | Protein of unknown function DUF2380 | DUF3280 | Family | 1,133 | false | false | This family of proteins with unknown function appears to be restricted to Proteobacteria. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF11684"
] | [
"DUF3280"
] | [
1133
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Durusdinium trenchii",
"ecological metagenomes"
] | [
1123,
1,
9
] | 3 | [] | [] | 0 | true | Family | Protein of unknown function DUF2380 | Protein of unknown function DUF2380 | DUF3280 | 8 |
IPR021699 | 21,699 | Protein of unknown function DUF3281 | DUF3281 | Family | 57 | false | false | This family of bacterial proteins has no known function. This entry includes bacterial lipoprotein FTN_103 from Francisella novicida [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF11685"
] | [
"DUF3281"
] | [
57
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00079182"
] | [
"22632124"
] | [
"Repression of bacterial lipoprotein production by Francisella novicida facilitates evasion of innate immune recognition."
] | [
2012
] | 1 | [] | [] | 0 | 0 | null | [
"Elysia chlorotica",
"Francisellaceae"
] | [
1,
56
] | 2 | [] | [] | 0 | true | Family | Protein of unknown function DUF3281 | Protein of unknown function DUF3281 | DUF3281 | 8 |
IPR021700 | 21,700 | Protein of unknown function DUF3283 | DUF3283 | Family | 405 | false | false | This family of proteins with unknown function appears to be restricted to Proteobacteria. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF11686"
] | [
"DUF3283"
] | [
405
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"marine sediment metagenome"
] | [
404,
1
] | 2 | [] | [] | 0 | true | Family | Protein of unknown function DUF3283 | Protein of unknown function DUF3283 | DUF3283 | 5 |
IPR021701 | 21,701 | Protein of unknown function DUF3284 | DUF3284 | Family | 915 | false | false | This family of proteins with unknown function appears to occur predominantly in Firmicutes. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF11687"
] | [
"DUF3284"
] | [
915
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"bioreactor metagenome"
] | [
913,
2
] | 2 | [] | [] | 0 | true | Family | Protein of unknown function DUF3284 | Protein of unknown function DUF3284 | DUF3284 | 7 |
IPR021702 | 21,702 | Protein of unknown function DUF3285 | DUF3285 | Family | 345 | false | false | This family of proteins with unknown function are mostly from Cyanobacteria. It displays a helix. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF11688"
] | [
"DUF3285"
] | [
345
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Cyanobacteriota",
"Eukaryota"
] | [
336,
9
] | 2 | [] | [] | 0 | true | Family | Protein of unknown function DUF3285 | Protein of unknown function DUF3285 | DUF3285 | 7 |
IPR021704 | 21,704 | Protein of unknown function DUF3287 | DUF3287 | Family | 497 | false | false | This eukaryotic family of proteins has no known function. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF11690"
] | [
"DUF3287"
] | [
497
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Acinetobacter schindleri NIPH 900",
"Camelineae"
] | [
1,
496
] | 2 | [
"Arabidopsis thaliana"
] | [
98
] | 1 | true | Family | Protein of unknown function DUF3287 | Protein of unknown function DUF3287 | DUF3287 | 5 |
IPR021705 | 21,705 | Protein of unknown function DUF3288 | DUF3288 | Family | 369 | false | false | This family of proteins with unknown function are mostly from Cyanobacteria. It contains an all helical fold. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF11691"
] | [
"DUF3288"
] | [
369
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Cyanobacteriota",
"Eukaryota"
] | [
363,
6
] | 2 | [] | [] | 0 | true | Family | Protein of unknown function DUF3288 | Protein of unknown function DUF3288 | DUF3288 | 2 |
IPR021706 | 21,706 | Protein of unknown function DUF2990 | DUF2990 | Family | 247 | false | false | This family of proteins represents a fungal protein with unknown function. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF11693"
] | [
"DUF2990"
] | [
247
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"leotiomyceta"
] | [
247
] | 1 | [] | [] | 0 | true | Family | Protein of unknown function DUF2990 | Protein of unknown function DUF2990 | DUF2990 | 1 |
IPR021707 | 21,707 | Protein of unknown function DUF3290 | DUF3290 | Family | 1,136 | false | false | This family of bacterial proteins is functionally uncharacterised. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF11694"
] | [
"DUF3290"
] | [
1136
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"metagenomes"
] | [
1134,
2
] | 2 | [] | [] | 0 | true | Family | Protein of unknown function DUF3290 | Protein of unknown function DUF3290 | DUF3290 | 7 |
IPR021709 | 21,709 | Protein of unknown function DUF3292 | DUF3292 | Family | 1,682 | false | false | This eukaryotic family of proteins has no known function. | [] | [] | [] | 0 | [
"PFAM",
"PANTHER"
] | [
"PF11696",
"PTHR38694"
] | [
"DUF3292",
""
] | [
1678,
1545
] | 2 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Azospirillum oleiclasticum",
"Eukaryota"
] | [
1,
1681
] | 2 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)"
] | [
1
] | 1 | true | Family | Protein of unknown function DUF3292 | Protein of unknown function DUF3292 | DUF3292 | 7 |
IPR021710 | 21,710 | Protein of unknown function DUF3293 | DUF3293 | Family | 1,650 | false | false | This bacterial family of proteins has no known function. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF11697"
] | [
"DUF3293"
] | [
1650
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Caudoviricetes",
"Eukaryota",
"metagenomes"
] | [
1540,
8,
67,
35
] | 4 | [] | [] | 0 | true | Family | Protein of unknown function DUF3293 | Protein of unknown function DUF3293 | DUF3293 | 7 |
IPR021711 | 21,711 | Domain of unknown function DUF3295 | DUF3295 | Domain | 1,771 | false | false | This is a conserved region found in fungi, whose function is unknown. They contain a GATA-like domain at the N-terminal ( ). | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF11702"
] | [
"DUF3295"
] | [
1771
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1771
] | 1 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)"
] | [
1
] | 1 | true | Domain | Domain of unknown function DUF3295 | Domain of unknown function DUF3295 | DUF3295 | 8 |
IPR021712 | 21,712 | Uncharacterised domain UPF0506 | UPF0506 | Domain | 302 | false | false | This uncharacterised family is found mainly in Schistosoma genomes. Although uncharacterised it appears to belong to the knottin fold. The sequence is composed of two repeats of a 6 cysteine motif. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF11703"
] | [
"UPF0506"
] | [
302
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
302
] | 1 | [] | [] | 0 | true | Domain | Uncharacterised domain UPF0506 | Uncharacterised domain UPF0506 | UPF0506 | 6 |
IPR021713 | 21,713 | Folliculin | Folliculin | Family | 3,071 | false | false | In yeast cells this family functions in the regulated delivery of Gap1p (a general amino acid permease) to the cell surface, perhaps as a component of a post-Golgi secretory-vesicle coat complex [ ]. Birt-Hogg-Dube (BHD)4 syndrome is an autosomal dominant disorder characterised by hamartomas of skin follicles, lung cys... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR31441"
] | [
""
] | [
3071
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-9639288",
"R-HSA-9639288",
"R-MMU-9639288",
"R-RNO-9639288",
"R-XTR-9639288"
] | [
"REACTOME:R-BTA-9639288",
"REACTOME:R-HSA-9639288",
"REACTOME:R-MMU-9639288",
"REACTOME:R-RNO-9639288",
"REACTOME:R-XTR-9639288"
] | 5 | [
"3v42",
"6nzd",
"6ulg",
"8dhb"
] | 4 | [
"PUB00053535",
"PUB00053536"
] | [
"9409822",
"17556368"
] | [
"Control of amino acid permease sorting in the late secretory pathway of Saccharomyces cerevisiae by SEC13, LST4, LST7 and LST8.",
"The Birt-Hogg-Dube and tuberous sclerosis complex homologs have opposing roles in amino acid homeostasis in Schizosaccharomyces pombe."
] | [
1997,
2007
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
3071
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strai... | [
7,
4,
1,
6,
2,
1,
2,
1,
1
] | 9 | true | Family | Folliculin | Folliculin | Folliculin | 1 |
IPR021714 | 21,714 | URB1, N-terminal | URB1_N | Domain | 4,181 | false | false | This entry represents a domain found at the N-terminal of URB1 and related proteins. Nucleolar pre-ribosomal-associated protein 1 (Npa1 or URB1) is required for ribosome biogenesis and operates in the same functional environment as Rsa3p and Dbp6p during early maturation of 60S ribosomal subunits [ ]. The protein partn... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF11707"
] | [
"Npa1"
] | [
4181
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00044526",
"PUB00053537"
] | [
"15226434",
"15208443"
] | [
"Npa1p, a component of very early pre-60S ribosomal particles, associates with a subset of small nucleolar RNPs required for peptidyl transferase center modification.",
"Npa1p is an essential trans-acting factor required for an early step in the assembly of 60S ribosomal subunits in Saccharomyces cerevisiae."
] | [
2004,
2004
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
4181
] | 1 | [
"Arabidopsis thaliana",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"... | [
13,
1,
1,
1,
2,
1,
2,
3,
1,
1,
6
] | 11 | true | Domain | URB1, N-terminal | URB1, N-terminal | URB1_N | 7 |
IPR021715 | 21,715 | Pre-mRNA-splicing factor SLU7 domain | Slu7_dom | Domain | 5,312 | false | false | The spliceosome, an assembly of snRNAs (U1, U2, U4/U6, and U5) and proteins, catalyses the excision of introns from pre-mRNAs in two successive trans-esterification reactions [ ]. Step 2 depends upon integral spliceosome constituents such as U5 snRNA and Prp8 and non-spliceosomal proteins Prp16, Slu7, Prp18, and Prp22.... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF11708"
] | [
"Slu7"
] | [
5312
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-159236",
"R-BTA-72163",
"R-BTA-72187",
"R-BTA-73856",
"R-CEL-159236",
"R-CEL-72163",
"R-CEL-72187",
"R-CEL-73856",
"R-DDI-72163",
"R-DME-159236",
"R-DME-72163",
"R-DME-72187",
"R-DME-73856",
"R-DRE-72163",
"R-HSA-159236",
"R-HSA-72163",
"R-HSA-72187",
"R-HSA-73856",
"R-MMU... | [
"REACTOME:R-BTA-159236",
"REACTOME:R-BTA-72163",
"REACTOME:R-BTA-72187",
"REACTOME:R-BTA-73856",
"REACTOME:R-CEL-159236",
"REACTOME:R-CEL-72163",
"REACTOME:R-CEL-72187",
"REACTOME:R-CEL-73856",
"REACTOME:R-DDI-72163",
"REACTOME:R-DME-159236",
"REACTOME:R-DME-72163",
"REACTOME:R-DME-72187",
"... | 26 | [
"5mps",
"5mq0",
"5xjc",
"5ylz",
"6bk8",
"6exn",
"6icz",
"6qdv",
"7b9v",
"7w5a",
"7w5b",
"8c6j",
"9dtr",
"9fmd"
] | 14 | [
"PUB00090374",
"PUB00090375"
] | [
"10197984",
"15181151"
] | [
"Human step II splicing factor hSlu7 functions in restructuring the spliceosome between the catalytic steps of splicing.",
"Splicing factor hSlu7 contains a unique functional domain required to retain the protein within the nucleus."
] | [
1999,
2004
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
5312
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
12,
1,
2,
2,
2,
3,
1,
1,
2,
1,
1,
8
] | 12 | true | Domain | Pre-mRNA-splicing factor SLU7 domain | Pre-mRNA-splicing factor SLU7 domain | Slu7_dom | 1 |
IPR021716 | 21,716 | Thrombin inhibitor Madanin | Inhibitor_I53 | Domain | 8 | false | false | Members of this family are the peptidase inhibitor madanin proteins. These proteins were isolated from tick saliva [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF11714"
] | [
"Inhibitor_I53"
] | [
8
] | 1 | [] | [] | [] | 0 | [
"4boh",
"5l6n"
] | 2 | [
"PUB00053538"
] | [
"12709051"
] | [
"Identification and characterization of novel salivary thrombin inhibitors from the ixodidae tick, Haemaphysalis longicornis."
] | [
2003
] | 1 | [] | [] | 0 | 0 | null | [
"Ixodidae",
"Neisseria oralis"
] | [
7,
1
] | 2 | [] | [] | 0 | true | Domain | Thrombin inhibitor Madanin | Thrombin inhibitor Madanin | Inhibitor_I53 | 9 |
IPR021717 | 21,717 | Nucleoporin Nup120/160 | Nucleoporin_Nup160 | Family | 4,946 | false | false | Nup120 is conserved from fungi to plants to humans, and is homologous with the Nup160 of vertebrates. The nuclear core complex, or NPC, mediates macromolecular transport across the nuclear envelope. Deletion of the NUP120 gene causes clustering of NPCs at one side of the nuclear envelope, moderate nucleolar fragmentati... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR21286"
] | [
""
] | [
4946
] | 1 | [
"GP",
"GP",
"GP",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
... | [
"GenProp2036",
"GenProp2037",
"GenProp2043",
"R-DME-159227",
"R-DME-159230",
"R-DME-159231",
"R-DME-159236",
"R-DME-170822",
"R-DME-3108214",
"R-DME-3301854",
"R-DME-4085377",
"R-DME-4551638",
"R-DME-4615885",
"R-DME-5578749",
"R-DME-9615933",
"R-HSA-1169408",
"R-HSA-141444",
"R-HS... | [
"GP:GenProp2036",
"GP:GenProp2037",
"GP:GenProp2043",
"REACTOME:R-DME-159227",
"REACTOME:R-DME-159230",
"REACTOME:R-DME-159231",
"REACTOME:R-DME-159236",
"REACTOME:R-DME-170822",
"REACTOME:R-DME-3108214",
"REACTOME:R-DME-3301854",
"REACTOME:R-DME-4085377",
"REACTOME:R-DME-4551638",
"REACTOME... | 88 | [
"3f7f",
"3h7n",
"3hxr",
"4fhm",
"4fhn",
"4gq2",
"4xmm",
"4xmn",
"4ycz",
"5a9q",
"6lk8",
"6x06",
"7fik",
"7n84",
"7n9f",
"7peq",
"7r5j",
"7r5k",
"7tbi",
"7tbj",
"7tbk",
"7tbl",
"7tbm",
"7tdz",
"7vci",
"7vop",
"7wb4",
"8tie",
"9hcj",
"9sob"
] | 30 | [
"PUB00019951",
"PUB00053539"
] | [
"11684705",
"8557736"
] | [
"Novel vertebrate nucleoporins Nup133 and Nup160 play a role in mRNA export.",
"Nup120p: a yeast nucleoporin required for NPC distribution and mRNA transport."
] | [
2001,
1995
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
4946
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
8,
2,
2,
2,
5,
1,
1,
4,
3,
1,
1,
32
] | 12 | true | Family | Nucleoporin Nup120/160 | Nucleoporin Nup120/160 | Nucleoporin_Nup160 | 4 |
IPR021718 | 21,718 | Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term | CPSF73-100_C | Domain | 5,133 | false | false | This is the C-terminal conserved region of the pre-mRNA 3'-end-processing of the polyadenylation factor CPSF-73/CPSF-100 proteins. The exact function of this domain is not known. | [] | [] | [] | 0 | [
"PFAM",
"SMART"
] | [
"PF11718",
"SM01098"
] | [
"CPSF73-100_C",
"CPSF73-100_C"
] | [
5124,
4759
] | 2 | [
"EC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
... | [
"3.1.27.-",
"R-BTA-159231",
"R-BTA-72187",
"R-BTA-72203",
"R-BTA-73856",
"R-BTA-77595",
"R-DDI-77595",
"R-DME-159231",
"R-DME-72187",
"R-DME-72203",
"R-DME-73856",
"R-DME-77595",
"R-HSA-159231",
"R-HSA-72187",
"R-HSA-72203",
"R-HSA-73856",
"R-HSA-77595",
"R-MMU-159231",
"R-MMU-72... | [
"EC:3.1.27.-",
"REACTOME:R-BTA-159231",
"REACTOME:R-BTA-72187",
"REACTOME:R-BTA-72203",
"REACTOME:R-BTA-73856",
"REACTOME:R-BTA-77595",
"REACTOME:R-DDI-77595",
"REACTOME:R-DME-159231",
"REACTOME:R-DME-72187",
"REACTOME:R-DME-72203",
"REACTOME:R-DME-73856",
"REACTOME:R-DME-77595",
"REACTOME:R... | 25 | [
"6v4x",
"8ba1"
] | 2 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
5133
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
3,
1,
1,
1,
6,
7,
1,
2,
7,
2,
1,
5
] | 12 | true | Domain | Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term | Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term | CPSF73-100_C | 8 |
IPR021719 | 21,719 | Proteinase inhibitor I78 | Prot_inh_I78 | Family | 5,099 | false | false | This family includes Aspergillus elastase inhibitor and belongs to MEROPS peptidase inhibitor family I78 [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF11720"
] | [
"Inhibitor_I78"
] | [
5099
] | 1 | [] | [] | [] | 0 | [
"3w0d",
"3w0e"
] | 2 | [
"PUB00075583"
] | [
"17287718"
] | [
"Characterization and primary structure of elastase inhibitor, AFLEI, from Aspergillus flavus."
] | [
2007
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
4075,
1016,
8
] | 3 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
1,
1
] | 2 | true | Family | Proteinase inhibitor I78 | Proteinase inhibitor I78 | Prot_inh_I78 | 9 |
IPR021720 | 21,720 | Malectin domain | Malectin_dom | Domain | 17,456 | false | false | Malectin is a membrane-anchored protein of the endoplasmic reticulum that recognises and binds Glc2-N-glycan. It carries a signal peptide from residues 1-26, a C-terminal transmembrane helix from residues 255-274, and a highly conserved central part of approximately 190 residues followed by an acidic, glutamate-rich re... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF11721"
] | [
"Malectin"
] | [
17456
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-DRE-6798695",
"R-HSA-532668",
"R-HSA-6798695",
"R-MMU-6798695",
"R-RNO-6798695"
] | [
"REACTOME:R-DRE-6798695",
"REACTOME:R-HSA-532668",
"REACTOME:R-HSA-6798695",
"REACTOME:R-MMU-6798695",
"REACTOME:R-RNO-6798695"
] | 5 | [
"2jwp",
"2k46",
"2kr2",
"5uj6",
"6d50",
"6d8g",
"6ed1",
"6nzg",
"6s7t",
"8dhl",
"9ikp",
"9il3",
"9ila",
"9ilf"
] | 14 | [
"PUB00048116",
"PUB00055598"
] | [
"18524852",
"20064227"
] | [
"Malectin: a novel carbohydrate-binding protein of the endoplasmic reticulum and a candidate player in the early steps of protein N-glycosylation.",
"Genome-wide cloning and sequence analysis of leucine-rich repeat receptor-like protein kinase genes in Arabidopsis thaliana."
] | [
2008,
2010
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Stenosarchaea group",
"metagenomes"
] | [
2791,
14547,
60,
58
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
100,
1,
1,
3,
4,
1,
72,
3,
55
] | 9 | true | Domain | Malectin domain | Malectin domain | Malectin_dom | 1 |
IPR021721 | 21,721 | Zinc finger, CCCH-type, TRM13 | Znf_CCCH-type_TRM13 | Domain | 2,367 | false | false | This domain is found at the N terminus of TRM13 methyltransferase proteins. It is presumed to be a zinc binding domain. | [
"GO:0008168"
] | [
"methyltransferase activity"
] | [
"molecular_function"
] | 1 | [
"PFAM"
] | [
"PF11722"
] | [
"zf-TRM13_CCCH"
] | [
2367
] | 1 | [
"EC",
"METACYC",
"REACTOME"
] | [
"2.1.1.225",
"PWY-6829",
"R-HSA-6782315"
] | [
"EC:2.1.1.225",
"METACYC:PWY-6829",
"REACTOME:R-HSA-6782315"
] | 3 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Marseillevirus sp."
] | [
6,
2360,
1
] | 3 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Zea mays"
] | [
5,
1,
1,
1,
6,
5,
2,
2,
1,
6
] | 10 | true | Domain | Zinc finger, CCCH-type, TRM13 | Zinc finger, CCCH-type, TRM13 | Znf_CCCH-type_TRM13 | 2 |
IPR021722 | 21,722 | YvbH-like, oligomerisation domain | YvbH_oligomer_dom | Domain | 834 | false | false | This domain is found at the C terminus of a group of bacterial uncharacterised proteins. This domain is composed of a helical hairpin that appears to mediate oligomerization based on the known structure [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF11724"
] | [
"YvbH_ext"
] | [
834
] | 1 | [] | [] | [] | 0 | [
"3b77"
] | 1 | [
"PUB00054230"
] | [
"19913036"
] | [
"Bacterial pleckstrin homology domains: a prokaryotic origin for the PH domain."
] | [
2010
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"bioreactor metagenome"
] | [
832,
2
] | 2 | [] | [] | 0 | true | Domain | YvbH-like, oligomerisation domain | YvbH-like, oligomerisation domain | YvbH_oligomer_dom | 4 |
IPR021724 | 21,724 | Protein of unknown function DUF3297 | DUF3297 | Family | 2,607 | false | false | This family is expressed in Proteobacteria and Actinobacteria. The function is not known. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF11730"
] | [
"DUF3297"
] | [
2607
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"ecological metagenomes"
] | [
2594,
4,
9
] | 3 | [] | [] | 0 | true | Family | Protein of unknown function DUF3297 | Protein of unknown function DUF3297 | DUF3297 | 4 |
IPR021725 | 21,725 | Pathogenicity locus | Cdd1 | Family | 1,322 | false | false | Cdd1 is expressed as part of the pathogenicity locus operon in several different orders of bacteria [ ]. Many members of the family are annotated as being putative mitomycin resistance proteins but this could not be confirmed. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF11731"
] | [
"Cdd1"
] | [
1322
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00053540"
] | [
"8973304"
] | [
"Definition of the single integration site of the pathogenicity locus in Clostridium difficile."
] | [
1996
] | 1 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Harvfovirus sp.",
"unclassified sequences"
] | [
30,
1269,
3,
1,
19
] | 5 | [] | [] | 0 | true | Family | Pathogenicity locus | Pathogenicity locus | Cdd1 | 3 |
IPR021726 | 21,726 | THO complex, subunitTHOC2, N-terminal | THO_THOC2_N | Domain | 5,348 | false | false | The THO/TREX complex is the transcription- and export-related complex associated with spliceosomes that preferentially deal with spliced mRNAs as opposed to unspliced mRNAs. Thoc2 plays a role in RNA polymerase II (RNA pol II)-dependent transcription and is required for the stability of DNA repeats [ ]. In humans, the ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF11732"
] | [
"Thoc2"
] | [
5348
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-159236",
"R-HSA-72187",
"R-HSA-73856",
"R-MMU-159236",
"R-MMU-72187",
"R-MMU-73856"
] | [
"REACTOME:R-HSA-159236",
"REACTOME:R-HSA-72187",
"REACTOME:R-HSA-73856",
"REACTOME:R-MMU-159236",
"REACTOME:R-MMU-72187",
"REACTOME:R-MMU-73856"
] | 6 | [
"7apk",
"7apx",
"7aqo",
"7luv",
"7v2w",
"7v2y",
"7znk",
"7znl",
"8r7l"
] | 9 | [
"PUB00018266",
"PUB00053541"
] | [
"9707445",
"17095540"
] | [
"A novel yeast gene, THO2, is involved in RNA pol II transcription and provides new evidence for transcriptional elongation-associated recombination.",
"Protein composition of human mRNPs spliced in vitro and differential requirements for mRNP protein recruitment."
] | [
1998,
2007
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Lysinibacillus agricola"
] | [
5347,
1
] | 2 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
12,
1,
2,
3,
3,
4,
1,
4,
5,
1,
1,
4
] | 12 | true | Domain | THO complex, subunitTHOC2, N-terminal | THO complex, subunitTHOC2, N-terminal | THO_THOC2_N | 2 |
IPR021728 | 21,728 | Protein of unknown function DUF3300 | DUF3300 | Family | 3,439 | false | false | This hypothetical bacterial gene product has a long hydrophobic segment and is thus likely to be a membrane protein. | [] | [] | [] | 0 | [
"PFAM",
"PANTHER"
] | [
"PF11737",
"PTHR40269"
] | [
"DUF3300",
""
] | [
3385,
3421
] | 2 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"metagenomes"
] | [
3437,
2
] | 2 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Protein of unknown function DUF3300 | Protein of unknown function DUF3300 | DUF3300 | 5 |
IPR021729 | 21,729 | Domain of unknown function DUF3298 | DUF3298 | Domain | 9,723 | false | false | This entry represents a highly conserved domain found in a group of bacterial proteins. The function of this domain is not known. Proteins containing this domain include pdaC and anti-sigma-V factor RsiV from Bacillus subtilis. PdaC catalyzes the deacetylation of N-acetylmuramic acid (MurNAc) residues in peptidoglycan,... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF11738"
] | [
"DUF3298"
] | [
9723
] | 1 | [] | [] | [] | 0 | [
"2hhi",
"3cyg",
"3s5t",
"4e72",
"5jen"
] | 5 | [
"PUB00084363"
] | [
"22277649"
] | [
"Identification and characterization of a novel polysaccharide deacetylase C (PdaC) from Bacillus subtilis."
] | [
2012
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Candidatus Methanolliviera hydrocarbonicum",
"Eukaryota",
"Siphoviridae sp. ctk4d14",
"unclassified sequences"
] | [
9614,
1,
8,
1,
99
] | 5 | [] | [] | 0 | true | Domain | Domain of unknown function DUF3298 | Domain of unknown function DUF3298 | DUF3298 | 2 |
IPR021730 | 21,730 | YdbH-like | YdbH | Family | 3,959 | false | false | This protein family includes the probable phospholipid transport protein YdbH protein from E.coli and similar proteins mainly found in proteobacteria. YdbH is one of the six AsmA-like paralogues in E.coli (YhdP, TamB, YdbH, AsmA, YicH, and YhjG) that have a variable size but share a similar predicted structure. In-dept... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF11739"
] | [
"YdbH-like"
] | [
3959
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00012843",
"PUB00104645",
"PUB00106658",
"PUB00155411"
] | [
"11803016",
"34781743",
"35226662",
"37455811"
] | [
"C4-dicarboxylate carriers and sensors in bacteria.",
"YhdP, TamB, and YdbH Are Redundant but Essential for Growth and Lipid Homeostasis of the Gram-Negative Outer Membrane.",
"Absence of YhdP, TamB, and YdbH leads to defects in glycerophospholipid transport and cell morphology in Gram-negative bacteria.",
"B... | [
2002,
2021,
2022,
2023
] | 4 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
3929,
9,
21
] | 3 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | YdbH-like | YdbH-like | YdbH | 6 |
IPR021731 | 21,731 | AMIN domain | AMIN_dom | Domain | 16,859 | false | false | This N-terminal domain of various bacterial protein families is crucial for the targetting of periplasmic or extracellular proteins to specific regions of the bacterial envelope. AMIN is derived from the N-terminal domain of AmiC, an N-acetylmuramoyl-l-alanine amidase of Escherichia coli which localises to the septal r... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF11741"
] | [
"AMIN"
] | [
16859
] | 1 | [] | [] | [] | 0 | [
"3jc8",
"3jc9",
"4aqz",
"4av2",
"4bin",
"6ve2",
"6ve3",
"6ve4",
"6w6m"
] | 9 | [
"PUB00053542"
] | [
"18723522"
] | [
"AMIN domains have a predicted role in localization of diverse periplasmic protein complexes."
] | [
2008
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Vibrio phage ST3",
"environmental samples",
"unclassified sequences"
] | [
16604,
22,
1,
2,
230
] | 5 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Domain | AMIN domain | AMIN domain | AMIN_dom | 3 |
IPR021732 | 21,732 | Protein of unknown function DUF3301 | DUF3301 | Family | 2,610 | false | false | This family is conserved in Proteobacteria, but the function is not known. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF11743"
] | [
"DUF3301"
] | [
2610
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Opisthokonta",
"unclassified sequences"
] | [
2569,
2,
39
] | 3 | [] | [] | 0 | true | Family | Protein of unknown function DUF3301 | Protein of unknown function DUF3301 | DUF3301 | 4 |
IPR021734 | 21,734 | Protein of unknown function DUF3303 | DUF3303 | Family | 1,322 | false | false | This entry represents an uncharacterised family of proteins mainly from prokaryotes. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF11746"
] | [
"DUF3303"
] | [
1322
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Florenciella sp. virus SA2",
"metagenomes"
] | [
199,
1021,
18,
1,
83
] | 5 | [] | [] | 0 | true | Family | Protein of unknown function DUF3303 | Protein of unknown function DUF3303 | DUF3303 | 4 |
IPR021735 | 21,735 | Protein of unknown function DUF3306 | DUF3306 | Family | 1,740 | false | false | This family of proteobacterial species proteins has no known function. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF11748"
] | [
"DUF3306"
] | [
1740
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"metagenomes"
] | [
1725,
15
] | 2 | [] | [] | 0 | true | Family | Protein of unknown function DUF3306 | Protein of unknown function DUF3306 | DUF3306 | 3 |
IPR021736 | 21,736 | Protein of unknown function DUF3305 | DUF3305 | Family | 1,747 | false | false | Several members of this family are annotated as being molybdopterin-guanine dinucleotide biosynthesis protein A; however, this could not be confirmed. The family is found in proteobacteria. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF11749"
] | [
"DUF3305"
] | [
1747
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"metagenomes"
] | [
1731,
16
] | 2 | [] | [] | 0 | true | Family | Protein of unknown function DUF3305 | Protein of unknown function DUF3305 | DUF3305 | 7 |
IPR021737 | 21,737 | Bacteriophage phiKZ, Orf197 | Phage_phiKZ_Orf197 | Family | 3,701 | false | false | This entry is represented by Bacteriophage phiKZ, Orf197. The characteristics of the protein distribution suggest prophage matches in addition to the phage matches. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF11750"
] | [
"DUF3307"
] | [
3701
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Hexamitidae",
"Stenosarchaea group",
"Viruses",
"metagenomes"
] | [
3421,
12,
30,
195,
43
] | 5 | [] | [] | 0 | true | Family | Bacteriophage phiKZ, Orf197 | Bacteriophage phiKZ, Orf197 | Phage_phiKZ_Orf197 | 8 |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.