LiteFold/InterPro · Datasets at Hugging Face

IPR021738

21,738

Protein of unknown function DUF3309

DUF3309

Family

3,172

false

This family is conserved in bacteria but its function is not known.

[]

0

[ "PFAM" ]

[ "PF11752" ]

[ "DUF3309" ]

[ 3172 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Protostomia", "ecological metagenomes" ]

[ 3145, 6, 21 ]

3

[]

0

true

Family

Protein of unknown function DUF3309

DUF3309

6

IPR021739

21,739

SaV-like

Family

2,821

false

This entry includes bacteriophage T7, Gp1.7, which is a nucleotide kinase that catalyzes the phosphorylation of dGMP and dTMP to dGDP and dTDP [ ]. It also includes SaV from Lactococcus phage p2, which is involved in sensitivity to the host abortive infection mechanism AbiV [ ]. The characteristics of the protein distr...

[]

0

[ "PFAM" ]

[ "PF11753" ]

[ "DUF3310" ]

[ 2821 ]

1

[]

0

[]

0

[ "PUB00070743", "PUB00082581" ]

[ "20497505", "19270128" ]

[ "A novel nucleotide kinase encoded by gene 1.7 of bacteriophage T7.", "Identification and characterization of the phage gene sav, involved in sensitivity to the lactococcal abortive infection mechanism AbiV." ]

[ 2010, 2009 ]

2

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 4, 1069, 7, 1677, 64 ]

5

[]

0

true

Family

SaV-like

6

IPR021740

21,740

Velvet factor

Velvet

Family

7,154

false

The velvet factor is conserved in many fungal species and is found to have gained different roles depending on the organism's need, expanding the conserved role in developmental programmes [ ]. The velvet factor orthologues can be adapted to the fungal-specific life cycle and may be involved in diverse functions such a...

[]

0

[ "PANTHER" ]

[ "PTHR33572" ]

[ "" ]

[ 7154 ]

1

[]

0

[ "4n6q", "4n6r", "9i2s" ]

3

[ "PUB00053490", "PUB00053491", "PUB00053492", "PUB00087162" ]

[ "17631397", "15294809", "16824096", "28481894" ]

[ "Neurospora crassa ve-1 affects asexual conidiation.", "veA is required for toxin and sclerotial production in Aspergillus parasiticus.", "The Aspergillus nidulans F-box protein GrrA links SCF activity to meiosis.", "The role of VosA/VelB-activated developmental gene vadA in Aspergillus nidulans." ]

[ 2008, 2004, 2006, 2017 ]

4

[]

0

null

[ "Eukaryota" ]

[ 7154 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)" ]

[ 4 ]

1

true

Family

Velvet factor

Velvet

9

IPR021741

21,741

Protein of unknown function DUF3311

DUF3311

Family

5,128

false

This is a family of short bacterial proteins of unknwon function.

[]

0

[ "PFAM", "PANTHER" ]

[ "PF11755", "PTHR40034" ]

[ "DUF3311", "" ]

[ 5042, 2070 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 368, 4647, 85, 28 ]

4

[]

0

true

Family

Protein of unknown function DUF3311

DUF3311

2

IPR021742

21,742

Suppressor of RNA silencing P21-like, N-terminal

RSS_P20_N

Domain

535

false

This entry represent a domain found in a group of putative suppressors of RNA silencing proteins, P20-P25, from ssRNA positive-strand viruses such as Closterovirus, Potyvirus and Cucumovirus families. RNA silencing is one of the major mechanisms of defence against viruses, and, in response, some viruses have evolved or...

[]

0

[ "PFAM" ]

[ "PF11757" ]

[ "RSS_P20" ]

[ 535 ]

1

[]

0

[ "2cwo" ]

1

[ "PUB00090995" ]

[ "12642093" ]

[ "Suppressor of RNA silencing encoded by Beet yellows virus." ]

[ 2003 ]

1

[]

0

null

[ "Closterovirus" ]

[ 535 ]

1

[]

0

true

Domain

Suppressor of RNA silencing P21-like, N-terminal

RSS_P20_N

3

IPR021743

21,743

Keratin-associated protein, type8/19/20/21/22

KRTAP_type8/19/20/21/22

Family

1,001

false

The major structural proteins of mammalian hair are the hair keratin intermediate filaments (KIFs) and the keratin-associated proteins (KRTAPs). In the hair cortex, hair keratins are embedded in an inter-filamentous matrix consisting of KRTAPs which are essential for the formation of a rigid and resistant hair shaft as...

[]

0

[ "PFAM" ]

[ "PF11759" ]

[ "KRTAP" ]

[ 1001 ]

1

[ "REACTOME", "REACTOME" ]

[ "R-HSA-6805567", "R-MMU-6805567" ]

[ "REACTOME:R-HSA-6805567", "REACTOME:R-MMU-6805567" ]

2

[]

0

[]

0

[]

[ "IPR039351", "IPR040313" ]

0

2

0

[ "Bacteria", "Eukaryota", "Paramecium bursaria Chlorella virus CVA-1", "freshwater metagenome" ]

[ 22, 977, 1, 1 ]

4

[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 15, 17, 13 ]

3

true

Family

Keratin-associated protein, type8/19/20/21/22

KRTAP_type8/19/20/21/22

9

IPR021744

21,744

Cobalamin synthesis G, N-terminal

CbiG_N

Domain

7,542

false

Members of this family are involved in cobalamin synthesis. The gene encoded by has been designated cbiH but in fact represents a fusion between cbiH and cbiG. As other multi-functional proteins involved in cobalamin biosynthesis catalyse adjacent steps in the pathway, including CysG, CobL (CbiET), CobIJ and CobA-HemD,...

[]

0

[ "PFAM" ]

[ "PF11760" ]

[ "CbiG_N" ]

[ 7542 ]

1

[ "EC", "METACYC" ]

[ "3.7.1.12", "PWY-7377" ]

[ "EC:3.7.1.12", "METACYC:PWY-7377" ]

2

[ "3eeq" ]

1

[ "PUB00000553" ]

[ "9742225" ]

[ "Cobalamin (vitamin B12) biosynthesis: identification and characterization of a Bacillus megaterium cobI operon." ]

[ 1998 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "metagenomes" ]

[ 588, 6862, 9, 83 ]

4

[]

0

true

Domain

Cobalamin synthesis G, N-terminal

CbiG_N

6

IPR021745

21,745

Cobalamin biosynthesis central region

CbiG_mid

Domain

3,630

false

Members of this family are involved in cobalamin synthesis. The gene encoded by has been designated cbiH but in fact represents a fusion between cbiH and cbiG. As other multi-functional proteins involved in cobalamin biosynthesis catalyse adjacent steps in the pathway, including CysG, CobL (CbiET), CobIJ and CobA-HemD,...

[]

0

[ "PFAM" ]

[ "PF11761" ]

[ "CbiG_mid" ]

[ 3630 ]

1

[]

0

[]

0

[ "PUB00000553" ]

[ "9742225" ]

[ "Cobalamin (vitamin B12) biosynthesis: identification and characterization of a Bacillus megaterium cobI operon." ]

[ 1998 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Metazoa", "metagenomes" ]

[ 79, 3502, 5, 44 ]

4

[]

0

true

Domain

Cobalamin biosynthesis central region

CbiG_mid

7

IPR021746

21,746

DIPSY domain

DIPSY

Domain

9

false

The DIPSY domain is characterised by the distinctive D*I*PSY motif at the very C terminus of yeast cell-wall glycoproteins. It appears not to be conserved in any other species, however. In fungi, cell adhesion is required for flocculation, mating and virulence, and is mediated by covalently bound cell wall proteins ter...

[]

0

[ "PFAM", "PROFILE" ]

[ "PF11763", "PS51825" ]

[ "DIPSY", "DIPSY" ]

[ 9, 8 ]

2

[]

0

[]

0

[ "PUB00053543" ]

[ "18673459" ]

[ "The Schizosaccharomyces pombe Map4 adhesin is a glycoprotein that can be extracted from the cell wall with alkali but not with beta-glucanases and requires the C-terminal DIPSY domain for function." ]

[ 2008 ]

1

[]

0

null

[ "Opisthokonta" ]

[ 9 ]

1

[ "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 4 ]

1

true

Domain

DIPSY domain

DIPSY

1

IPR021747

21,747

Protein of unknown function DUF3313

DUF3313

Family

3,980

false

This a bacterial family of proteins which are annotated as putative lipoproteins.

[]

0

[ "PFAM" ]

[ "PF11769" ]

[ "DUF3313" ]

[ 3980 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Opisthokonta", "metagenomes" ]

[ 3961, 3, 16 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Protein of unknown function DUF3313

DUF3313

3

IPR021748

21,748

Protein of unknown function DUF3314

DUF3314

Family

475

false

This small family contains human, mouse and fish members but the function is not known.

[]

0

[ "PFAM" ]

[ "PF11771" ]

[ "DUF3314" ]

[ 475 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Gnathostomata" ]

[ 475 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 2, 6, 2 ]

4

true

Family

Protein of unknown function DUF3314

DUF3314

4

IPR021749

21,749

Competence protein ComGE

ComGE

Family

533

false

This entry includes the competence protein ComGE (protein E of the comG locus), found in multiple species of Streptococcus. It is required for formation of the type IV-like pilus (T4P) that plays a role in transformation [ , ].

[]

0

[ "PFAM" ]

[ "PF11773" ]

[ "ComGE" ]

[ 533 ]

1

[]

0

[]

0

[ "PUB00101164", "PUB00106112" ]

[ "23825953", "35004361" ]

[ "A type IV pilus mediates DNA binding during natural transformation in Streptococcus pneumoniae.", "The Role of Minor Pilins in Assembly and Function of the Competence Pilus of Streptococcus pneumoniae." ]

[ 2013, 2021 ]

2

[ "IPR053468" ]

[]

1

0

1

[ "Bacteria" ]

[ 533 ]

1

[]

0

true

Family

Competence protein ComGE

ComGE

9

IPR021750

21,750

Septation initiation Sid4-like

Sid4-like

Family

160

false

This entry includes fission yeast Sid4 and its homologue, Ady3 and Cnm67, from budding yeasts.

[]

0

[ "PFAM" ]

[ "PF11778" ]

[ "SID" ]

[ 160 ]

1

[]

0

[ "3oa7" ]

1

[ "PUB00053546", "PUB00053547", "PUB00053548", "PUB00053549", "PUB00074993" ]

[ "10805785", "11676915", "15062098", "11514632", "11973299" ]

[ "Sid4p is required to localize components of the septation initiation pathway to the spindle pole body in fission yeast.", "S. pombe cdc11p, together with sid4p, provides an anchor for septation initiation network proteins on the spindle pole body.", "Sid4p-Cdc11p assembles the septation initiation network and ...

[ 2000, 2001, 2004, 2001, 2002 ]

5

[]

0

null

[ "Ascomycota" ]

[ 160 ]

1

[ "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 2, 1 ]

2

true

Family

Septation initiation Sid4-like

Sid4-like

8

IPR021751

21,751

Protein of unknown function DUF3318

DUF3318

Family

833

false

This is a bacterial family of uncharacterised proteins.

[]

0

[ "PFAM" ]

[ "PF11780" ]

[ "DUF3318" ]

[ 833 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Paulinella", "marine metagenome" ]

[ 829, 3, 1 ]

3

[]

0

true

Family

Protein of unknown function DUF3318

DUF3318

4

IPR021753

21,753

Domain of unknown function DUF3319

DUF3319

Domain

354

false

This is a domain of unknown function in short, uncharacterised bacterial proteins. Some of these proteins are annotated as being minor tail proteins.

[]

0

[ "PFAM" ]

[ "PF11782" ]

[ "DUF3319" ]

[ 354 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria" ]

[ 354 ]

1

[]

0

true

Domain

Domain of unknown function DUF3319

DUF3319

4

IPR021755

21,755

Transcription factor Aft1, HRA domain

TF_Aft1_HRA

Domain

1,556

false

This domain is found in the transcription factor Aft1 which is required for a wide range of stress responses. The HRA domain is involved in meiotic recombination. It has been shown to be necessary and sufficient to activate recombination [ ]. Atf1 is a bZIP family transcription factor found in the postharvest pathogen ...

[]

0

[ "PFAM" ]

[ "PF11786" ]

[ "Aft1_HRA" ]

[ 1556 ]

1

[ "REACTOME", "REACTOME" ]

[ "R-SPO-3214847", "R-SPO-450341" ]

[ "REACTOME:R-SPO-3214847", "REACTOME:R-SPO-450341" ]

2

[]

0

[ "PUB00053258", "PUB00163232" ]

[ "18375981", "39802737" ]

[ "Distinct regions of ATF/CREB proteins Atf1 and Pcr1 control recombination hotspot ade6-M26 and the osmotic stress response.", "Chromatin accessibility profile and the role of PeAtf1 transcription factor in the postharvest pathogen Penicillium expansum." ]

[ 2008, 2025 ]

2

[]

0

null

[ "Eukaryota" ]

[ 1556 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 2, 1 ]

2

true

Domain

Transcription factor Aft1, HRA domain

TF_Aft1_HRA

7

IPR021756

21,756

Transcription factor Aft1, HRR domain

TF_Aft1_HRR

Domain

1,076

false

This domain is found in the transcription factor Aft1 which is required for a wide range of stress responses. The HRR domain is involved in meiotic recombination. It has been shown to be necessary and sufficient to repress recombination [ ]. Atf1 is a bZIP family transcription factor found in the postharvest pathogen P...

[]

0

[ "PFAM" ]

[ "PF11787" ]

[ "Aft1_HRR" ]

[ 1076 ]

1

[]

0

[]

0

[ "PUB00053258", "PUB00163232" ]

[ "18375981", "39802737" ]

[ "Distinct regions of ATF/CREB proteins Atf1 and Pcr1 control recombination hotspot ade6-M26 and the osmotic stress response.", "Chromatin accessibility profile and the role of PeAtf1 transcription factor in the postharvest pathogen Penicillium expansum." ]

[ 2008, 2025 ]

2

[]

0

null

[ "Eukaryota" ]

[ 1076 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)" ]

[ 2 ]

1

true

Domain

Transcription factor Aft1, HRR domain

TF_Aft1_HRR

6

IPR021757

21,757

Large ribosomal subunit protein mL46, N-terminal

Ribosomal_mL46_N

Domain

3,257

false

This entry represents the N-terminal domain found in the mitochondrial large ribosomal subunit protein mL46, also known as MRLP46 in mammals [ ] and MRLP17 in yeasts Saccharomyces cerevisiae and Schizosaccharomyces pombe [ ].

[]

0

[ "PFAM" ]

[ "PF11788" ]

[ "MRP-L46" ]

[ 3257 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-5389840", "R-BTA-5419276", "R-BTA-9937383", "R-HSA-5368286", "R-HSA-5389840", "R-HSA-5419276", "R-HSA-9937383", "R-MMU-5389840", "R-MMU-5419276", "R-MMU-9937383", "R-RNO-5389840", "R-RNO-5419276", "R-RNO-9937383" ]

[ "REACTOME:R-BTA-5389840", "REACTOME:R-BTA-5419276", "REACTOME:R-BTA-9937383", "REACTOME:R-HSA-5368286", "REACTOME:R-HSA-5389840", "REACTOME:R-HSA-5419276", "REACTOME:R-HSA-9937383", "REACTOME:R-MMU-5389840", "REACTOME:R-MMU-5419276", "REACTOME:R-MMU-9937383", "REACTOME:R-RNO-5389840", "REACTOM...

13

[ "3j6b", "3j7y", "3j9m", "4v1a", "5aj4", "5mrc", "5mre", "5mrf", "5ool", "5oom", "6gaw", "6gb2", "6hiv", "6hix", "6i9r", "6nu2", "6nu3", "6vlz", "6vmi", "6ydp", "6ydw", "6ywe", "6yws", "6ywv", "6ywx", "6ywy", "6zm5", "6zm6", "6zs9", "6zsa", "6zsb", "6zsc"...

100

[ "PUB00087081", "PUB00089007" ]

[ "24675956", "25278503" ]

[ "Structure of the yeast mitochondrial large ribosomal subunit.", "Structure of the large ribosomal subunit from human mitochondria." ]

[ 2014, 2014 ]

2

[]

0

null

[ "Eukaryota" ]

[ 3257 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strai...

[ 1, 1, 1, 3, 1, 1, 3, 1, 1 ]

9

true

Domain

Large ribosomal subunit protein mL46, N-terminal

Ribosomal_mL46_N

5

IPR021758

21,758

Baculoviridae late expression factor 5, C-terminal

Baculo_LEF5_C

Domain

157

false

This C-terminal domain is likely to be a zinc-binding domain.

[]

0

[ "PFAM" ]

[ "PF11792" ]

[ "Baculo_LEF5_C" ]

[ 157 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Neoptera", "Viruses" ]

[ 2, 155 ]

2

[]

0

true

Domain

Baculoviridae late expression factor 5, C-terminal

Baculo_LEF5_C

5

IPR021761

21,761

UDP-glucuronate decarboxylase N-terminal

UXS1_N

Domain

1,035

false

The N terminus of the UDP-glucuronate decarboxylases may be involved in localisation to the perinuclear Golgi membrane [ , ].

[ "GO:0048040" ]

[ "UDP-glucuronate decarboxylase activity" ]

[ "molecular_function" ]

1

[ "PFAM" ]

[ "PF11803" ]

[ "UXS1_N" ]

[ 1035 ]

1

[ "EC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "4.1.1.35", "PWY-4821", "R-DRE-173599", "R-DRE-1971475", "R-HSA-173599", "R-HSA-1971475", "R-MMU-173599", "R-MMU-1971475", "R-RNO-173599", "R-RNO-1971475", "R-XTR-173599", "R-XTR-1971475" ]

[ "EC:4.1.1.35", "METACYC:PWY-4821", "REACTOME:R-DRE-173599", "REACTOME:R-DRE-1971475", "REACTOME:R-HSA-173599", "REACTOME:R-HSA-1971475", "REACTOME:R-MMU-173599", "REACTOME:R-MMU-1971475", "REACTOME:R-RNO-173599", "REACTOME:R-RNO-1971475", "REACTOME:R-XTR-173599", "REACTOME:R-XTR-1971475" ]

12

[]

0

[ "PUB00057839", "PUB00057840" ]

[ "11877387", "18485801" ]

[ "UDP-glucuronate decarboxylase, a key enzyme in proteoglycan synthesis: cloning, characterization, and localization.", "Golgi transporters: opening the gate to cell wall polysaccharide biosynthesis." ]

[ 2002, 2008 ]

2

[]

0

null

[ "Opisthokonta" ]

[ 1035 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 2, 5, 13 ]

4

true

Domain

UDP-glucuronate decarboxylase N-terminal

UXS1_N

5

IPR021762

21,762

Protein of unknown function DUF3325

DUF3325

Family

2,737

false

This family of short proteins are functionally uncharacterised. This family is restricted to Alpha-, Beta- and Gamma-proteobacteria.

[]

0

[ "PFAM" ]

[ "PF11804" ]

[ "DUF3325" ]

[ 2737 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Opisthokonta", "metagenomes" ]

[ 2712, 3, 22 ]

3

[]

0

true

Family

Protein of unknown function DUF3325

DUF3325

5

IPR021763

21,763

Protein of unknown function DUF3326

DUF3326

Family

1,156

false

This family of functionally uncharacterised proteins is found in plants and bacteria.

[]

0

[ "PFAM", "PANTHER" ]

[ "PF11805", "PTHR36891" ]

[ "DUF3326", "" ]

[ 1156, 1131 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "metagenomes" ]

[ 4, 442, 655, 55 ]

4

[ "Oryza sativa subsp. japonica", "Zea mays" ]

[ 3, 9 ]

2

true

Family

Protein of unknown function DUF3326

DUF3326

2

IPR021764

21,764

Enterochelin esterase, N-terminal

Enterochelin_esterase_N

Domain

3,885

false

This entry represents the N-terminal domain of enterochelin esterase. The activity of the enzyme has been characterised [ , , ]. Fes catalyses the hydrolysis of the 2,3-dihydroxy-N-benzoyl-L-serine trimer, enterochelin, forming 2,3-dihydroxybenzoylserine. It also catalyses hydrolysis of free enterobactin and ferric ent...

[ "GO:0005506", "GO:0008849", "GO:0006826", "GO:0005737" ]

[ "iron ion binding", "enterochelin esterase activity", "iron ion transport", "cytoplasm" ]

[ "molecular_function", "molecular_function", "biological_process", "cellular_component" ]

4

[ "PFAM" ]

[ "PF11806" ]

[ "Enterochelin_N" ]

[ 3885 ]

1

[ "EC", "REACTOME" ]

[ "3.1.1.108", "R-HSA-9638334" ]

[ "EC:3.1.1.108", "REACTOME:R-HSA-9638334" ]

2

[ "2b20", "3c87", "3c8d", "3c8h", "3mga" ]

5

[ "PUB00053481", "PUB00053482", "PUB00097189" ]

[ "150859", "1534808", "16076215" ]

[ "Enzymatic hydrolysis of enterochelin and its iron complex in Escherichia Coli K-12. Properties of enterochelin esterase.", "Overexpression and purification of ferric enterobactin esterase from Escherichia coli. Demonstration of enzymatic hydrolysis of enterobactin and its iron complex.", "In vitro characteriza...

[ 1978, 1992, 2005 ]

3

[]

0

null

[ "Bacteria", "Beauveria bassiana D1-5", "ecological metagenomes" ]

[ 3881, 1, 3 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Domain

Enterochelin esterase, N-terminal

Enterochelin_esterase_N

2

IPR021765

21,765

Mycotoxin biosynthesis protein UstYa-like

UstYa-like

Family

15,406

false

Oxidase ustYa is involved in the the production of ustiloxins, toxic cyclic peptides, in fungi. Ustiloxins were found to be the first example of cyclic peptidyl secondary metabolites that are ribosomally synthesized in filamentous fungi. The homologous genes ustYa and ustYb (which are found in the gene cluster for usti...

[ "GO:0043386" ]

[ "mycotoxin biosynthetic process" ]

[ "biological_process" ]

1

[ "PFAM", "PANTHER" ]

[ "PF11807", "PTHR33365" ]

[ "UstYa", "" ]

[ 15377, 14755 ]

2

[]

0

[]

0

[ "PUB00082329", "PUB00082330", "PUB00082331", "PUB00083227" ]

[ "27166860", "26703898", "24841822", "26954535" ]

[ "Unveiling the Biosynthetic Pathway of the Ribosomally Synthesized and Post-translationally Modified Peptide Ustiloxin B in Filamentous Fungi.", "Class of cyclic ribosomal peptide synthetic genes in filamentous fungi.", "Characterization of the biosynthetic gene cluster for the ribosomally synthesized cyclic pe...

[ 2016, 2016, 2014, 2016 ]

4

[]

0

null

[ "Eukaryota" ]

[ 15406 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)" ]

[ 7 ]

1

true

Family

Mycotoxin biosynthesis protein UstYa-like

UstYa-like

5

IPR021766

21,766

Phosphate regulon sensor protein PhoR, N-terminal domain

PhoR_N

Domain

5,825

false

This entry represents the N-terminal domain of Phosphate regulon sensor protein PhoR from Escherichia coli and similar proteins mainly found in proteobacteria. PhoR is a member of the two-component regulatory system PhoR/PhoB involved in the phosphate regulon genes expression. PhoR is the bifunctional histidine autokin...

[ "GO:0000155", "GO:0004721", "GO:0000160" ]

[ "phosphorelay sensor kinase activity", "phosphoprotein phosphatase activity", "phosphorelay signal transduction system" ]

[ "molecular_function", "molecular_function", "biological_process" ]

3

[ "PFAM" ]

[ "PF11808" ]

[ "PhoR" ]

[ 5825 ]

1

[ "EC" ]

[ "2.7.13.3" ]

[ "EC:2.7.13.3" ]

1

[]

0

[ "PUB00076908" ]

[ "24563032" ]

[ "The PhoU protein from Escherichia coli interacts with PhoR, PstB, and metals to form a phosphate-signaling complex at the membrane." ]

[ 2014 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 5770, 7, 48 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Domain

Phosphate regulon sensor protein PhoR, N-terminal domain

PhoR_N

8

IPR021767

21,767

Transposon Tn21 modulator protein

TnpM

Family

726

false

TnpM enhances the Tn21 transposition by activating expression of the transposase gene and decreases the resolution of the cointegrated DNA by suppressing expression of the resolvase gene [ ].

[]

0

[ "PFAM" ]

[ "PF11809" ]

[ "DUF3330" ]

[ 726 ]

1

[]

0

[]

0

[ "PUB00086411" ]

[ "2992807" ]

[ "tnpM: a novel regulatory gene that enhances Tn21 transposition and suppresses cointegrate resolution." ]

[ 1985 ]

1

[]

0

null

[ "Bacteria", "Sym plasmid", "Viruses", "ecological metagenomes" ]

[ 712, 1, 2, 11 ]

4

[]

0

true

Family

Transposon Tn21 modulator protein

TnpM

5

IPR021768

21,768

Protein of unknown function DUF3332

DUF3332

Family

1,149

false

This family of proteins is functionally uncharacterised.

[]

0

[ "PFAM" ]

[ "PF11810" ]

[ "DUF3332" ]

[ 1149 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Microviridae sp. ctC1P1", "unclassified sequences" ]

[ 1122, 1, 26 ]

3

[]

0

true

Family

Protein of unknown function DUF3332

DUF3332

6

IPR021769

21,769

Protein of unknown function DUF3331

DUF3331

Family

1,241

false

This family of proteins are functionally uncharacterised. This family is only found in bacteria. Proteins in this family vary in length from 96 to 160 amino acids.

[]

0

[ "PFAM" ]

[ "PF11811" ]

[ "DUF3331" ]

[ 1241 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Pseudomonadota", "Ricinus communis" ]

[ 1239, 2 ]

2

[]

0

true

Family

Protein of unknown function DUF3331

DUF3331

2

IPR021771

21,771

Triacylglycerol lipase, N-terminal

Triacylglycerol_lipase_N

Domain

6,564

false

This is an N-terminal domain that is found adjacent to the patatin/phospholipase A2-related domain (see ) in a group of proteins. Proteins containing this domain include Tgl3/4/5 from Saccharomyces cerevisiae. Tgl3 is a bifunctional triacylglycerol lipase and lysophospholipid acyltransferase [ ]. Tgl4/5 are multifuncti...

[ "GO:0004806", "GO:0006629" ]

[ "triacylglycerol lipase activity", "lipid metabolic process" ]

[ "molecular_function", "biological_process" ]

2

[ "PFAM" ]

[ "PF11815" ]

[ "DUF3336" ]

[ 6564 ]

1

[ "EC", "GP", "GP", "GP", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", ...

[ "3.1.1.-", "GenProp1316", "GenProp1575", "GenProp1718", "PWY-1921", "PWY-5835", "PWY-6190", "PWY-6308", "PWY-6322", "PWY-6339", "PWY-6415", "PWY-6558", "PWY-6848", "PWY-7002", "PWY-7352", "PWY-7367", "PWY-7521", "PWY-7599", "PWY-7660", "PWY-7712", "PWY-7713", "PWY-7730", ...

[ "EC:3.1.1.-", "GP:GenProp1316", "GP:GenProp1575", "GP:GenProp1718", "METACYC:PWY-1921", "METACYC:PWY-5835", "METACYC:PWY-6190", "METACYC:PWY-6308", "METACYC:PWY-6322", "METACYC:PWY-6339", "METACYC:PWY-6415", "METACYC:PWY-6558", "METACYC:PWY-6848", "METACYC:PWY-7002", "METACYC:PWY-7352", ...

31

[]

0

[ "PUB00053878", "PUB00053879", "PUB00074905", "PUB00074906", "PUB00074907", "PUB00074908" ]

[ "12682047", "20016004", "16135509", "20332534", "16473965", "19136267" ]

[ "YMR313c/TGL3 encodes a novel triacylglycerol lipase located in lipid particles of Saccharomyces cerevisiae.", "Janus-faced enzymes yeast Tgl3p and Tgl5p catalyze lipase and acyltransferase reactions.", "Tgl4p and Tgl5p, two triacylglycerol lipases of the yeast Saccharomyces cerevisiae are localized to lipid pa...

[ 2003, 2010, 2005, 2010, 2006, 2009 ]

6

[]

0

null

[ "Eukaryota", "Pseudomonadota", "ecological metagenomes" ]

[ 6007, 554, 3 ]

3

[ "Arabidopsis thaliana", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)", "Zea mays" ]

[ 5, 3, 7, 3, 3, 9 ]

6

true

Domain

Triacylglycerol lipase, N-terminal

Triacylglycerol_lipase_N

1

IPR021772

21,772

WDR48/Bun107, ubiquitin-like domain

WDR48/Bun107_Ubl

Domain

5,036

false

This entry represents the ubiquitin-like domain of WDR48 from animals, Bun107 from fission yeasts and Duf1 from budding yeasts. WDR48 (also known as UAF1) is a regulator of deubiquitinating complexes [ , , ]. Bun107 is required for the Ubp9 recruitment to septa and cell tips but also for its enzymatic activity at these...

[]

0

[ "PFAM" ]

[ "PF11816" ]

[ "DUF3337" ]

[ 5036 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-CEL-5689880", "R-DDI-5689880", "R-DME-5689880", "R-DRE-110314", "R-GGA-110314", "R-GGA-5689880", "R-GGA-6783310", "R-HSA-110314", "R-HSA-5689880", "R-HSA-6783310", "R-HSA-9673766", "R-MMU-110314", "R-MMU-5689880", "R-MMU-6783310", "R-SPO-110314", "R-SPO-5689880", "R-XTR-110314", ...

[ "REACTOME:R-CEL-5689880", "REACTOME:R-DDI-5689880", "REACTOME:R-DME-5689880", "REACTOME:R-DRE-110314", "REACTOME:R-GGA-110314", "REACTOME:R-GGA-5689880", "REACTOME:R-GGA-6783310", "REACTOME:R-HSA-110314", "REACTOME:R-HSA-5689880", "REACTOME:R-HSA-6783310", "REACTOME:R-HSA-9673766", "REACTOME:R...

18

[ "5cvl", "5cvn", "5k1a", "5k1b", "5l8e", "5l8w", "6jlq", "7ay1", "8a9j", "8a9k", "9di1", "9di2", "9ebs", "9hnw" ]

14

[ "PUB00057398", "PUB00092494", "PUB00092495", "PUB00092496" ]

[ "20838651", "18082604", "19075014", "26388029" ]

[ "A global census of fission yeast deubiquitinating enzyme localization and interaction networks reveals distinct compartmentalization profiles and overlapping functions in endocytosis and polarity.", "A UAF1-containing multisubunit protein complex regulates the Fanconi anemia pathway.", "UAF1 is a subunit of mu...

[ 2010, 2007, 2009, 2015 ]

4

[]

0

null

[ "Eukaryota" ]

[ 5036 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 4, 1, 6, 2, 2, 1, 1, 5, 5, 1, 1, 21 ]

12

true

Domain

WDR48/Bun107, ubiquitin-like domain

WDR48/Bun107_Ubl

9

IPR021773

21,773

Trafficking protein particle complex subunit 11

TPC11

Domain

5,608

false

This entry represents a domain found in trafficking protein particle complex subunit 11 (Trappc11), which is involved in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage [ ]. The C terminus of this region contains TPR repeats. In zebrafish, Trappc11 is also known as protein foie gras. It has b...

[]

0

[ "PFAM" ]

[ "PF11817" ]

[ "Foie-gras_1" ]

[ 5608 ]

1

[ "REACTOME", "REACTOME" ]

[ "R-HSA-8876198", "R-MMU-8876198" ]

[ "REACTOME:R-HSA-8876198", "REACTOME:R-MMU-8876198" ]

2

[ "7b6h", "7b6r", "7b6z", "7b70" ]

4

[ "PUB00053551", "PUB00075414" ]

[ "16000385", "21525244" ]

[ "A genetic screen in zebrafish identifies the mutants vps18, nf2 and foie gras as models of liver disease.", "C4orf41 and TTC-15 are mammalian TRAPP components with a role at an early stage in ER-to-Golgi trafficking." ]

[ 2005, 2011 ]

2

[]

0

null

[ "Eukaryota" ]

[ 5608 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 7, 2, 2, 4, 4, 1, 1, 5, 6, 22 ]

10

true

Domain

Trafficking protein particle complex subunit 11

TPC11

7

IPR021774

21,774

Cytohesin Ubiquitin Protein Inducing Domain

CUPID

Domain

6,370

false

This entry represents a domain named CUPID (Cytohesin Ubiquitin Protein Inducing Domain) that is found in animal proteins. It is found towards the N-terminal end of Innate immunity activator protein (INAVA, Innate Immune Activator), a risk factor for the chronic inflammatory bowel diseases (IBD). Mice lacking the prote...

[]

0

[ "PFAM" ]

[ "PF11819" ]

[ "CUPID" ]

[ 6370 ]

1

[]

0

[]

0

[ "PUB00088936", "PUB00101049", "PUB00101050" ]

[ "28422092", "30355448", "27044754" ]

[ "Hierarchical assembly of centriole subdistal appendages via centrosome binding proteins CCDC120 and CCDC68.", "INAVA-ARNO complexes bridge mucosal barrier function with inflammatory signaling.", "FRMD4A-cytohesin signaling modulates the cellular release of tau." ]

[ 2017, 2018, 2016 ]

3

[]

0

null

[ "Eukaryota", "candidate division WS6 bacterium GW2011_GWF2_39_15" ]

[ 6369, 1 ]

2

[ "Caenorhabditis elegans", "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 7, 66, 13, 16, 25 ]

5

true

Domain

Cytohesin Ubiquitin Protein Inducing Domain

CUPID

2

IPR021775

21,775

Protein of unknown function DUF3339

DUF3339

Family

3,552

false

This family of proteins are functionally uncharacterised. This family is found in eukaryotes. Proteins in this family are about 70 amino acids in length.

[]

0

[ "PFAM", "PANTHER" ]

[ "PF11820", "PTHR33128" ]

[ "DUF3339", "" ]

[ 3552, 3446 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Eukaryota", "Viruses", "viral metagenome" ]

[ 3528, 6, 18 ]

3

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 31, 26, 36 ]

3

true

Family

Protein of unknown function DUF3339

DUF3339

3

IPR021776

21,776

Alternative complex III, ActD subunit

ActD

Family

3,242

false

Alternative complex III (ACIII) is a multisubunit quinol:electron acceptor oxidoreductase that couples quinol oxidation with transmembrane proton translocation similar to bc1 complex (or complex III). It is a key component of the respiratory and photosynthetic electron transport chains in many bacteria. It has six subu...

[]

0

[ "PFAM" ]

[ "PF11821" ]

[ "ActD" ]

[ 3242 ]

1

[]

0

[ "6btm", "6f0k", "6lod", "6loe", "8k9e", "8k9f", "8x2j", "9ilt" ]

8

[ "PUB00099731", "PUB00099732" ]

[ "29695868", "32832681" ]

[ "Structure of the alternative complex III in a supercomplex with cytochrome oxidase.", "Cryo-EM structures of the air-oxidized and dithionite-reduced photosynthetic alternative complex III from Roseiflexus castenholzii." ]

[ 2018, 2020 ]

2

[]

0

null

[ "Bacteria", "Candidatus Methanoperedens nitratireducens", "Eukaryota", "ecological metagenomes" ]

[ 3161, 1, 6, 74 ]

4

[]

0

true

Family

Alternative complex III, ActD subunit

ActD

7

IPR021777

21,777

SANT and BTB domain regulator of CSR, BTB domain

SANBR_BTB

Domain

1,676

false

Class switch recombination (CSR) is the process by which B cells switch production from IgM/IgD to other immunoglobulin isotypes in the immune response process. This entry represents the BTB domain found at the N-terminal half of the protein SANT and BTB domain regulator of class switch recombination (SANBR, previously...

[]

0

[ "PFAM" ]

[ "PF11822" ]

[ "BTB_SANBR" ]

[ 1676 ]

1

[]

0

[]

0

[ "PUB00099259" ]

[ "33831416" ]

[ "The uncharacterized SANT and BTB domain-containing protein SANBR inhibits class switch recombination." ]

[ 2021 ]

1

[]

0

null

[ "Eukaryota" ]

[ 1676 ]

1

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 3, 1, 3, 5 ]

5

true

Domain

SANT and BTB domain regulator of CSR, BTB domain

SANBR_BTB

6

IPR021778

21,778

Putative Se/S carrier protein-like

Se/S_carrier-like

Domain

3,428

false

This domain is found in bacteria and archaea. It has been suggested that proteins in this family may be chaperones involved in Se or S trafficking in the cell [ ].

[]

0

[ "PFAM" ]

[ "PF11823" ]

[ "Se_S_carrier" ]

[ 3428 ]

1

[]

0

[]

0

[ "PUB00098047" ]

[ "25638258" ]

[ "Comparative genomics reveals new candidate genes involved in selenium metabolism in prokaryotes." ]

[ 2015 ]

1

[]

0

null

[ "Bacteria", "Methanomada group", "Siphoviridae sp. ctg0K17", "metagenomes" ]

[ 3331, 33, 1, 63 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Domain

Putative Se/S carrier protein-like

Se/S_carrier-like

9

IPR021779

21,779

Domain of unknown function DUF3344

DUF3344

Domain

508

false

This presumed domain is found proteins that are functionally uncharacterised, found in bacteria and archaea. Proteins in this family are typically between 367 to 1857 amino acids in length.

[]

0

[ "PFAM" ]

[ "PF11824" ]

[ "DUF3344" ]

[ 508 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Gracilariopsis chorda", "Methanobacteriota", "freshwater metagenome" ]

[ 100, 1, 406, 1 ]

4

[]

0

true

Domain

Domain of unknown function DUF3344

DUF3344

7

IPR021780

21,780

Nuclear/hormone receptor activator site AF-1

Nuc_recep-AF1

Domain

4,221

false

Nuclear receptors (NRs) are a family of ligand-inducible transcription factors, and, like other transcription factors, they contain a distinct DNA binding domain that allows for target gene recognition and several activation domains that possess the ability to activate transcription [ ]. One of these activation domains...

[]

0

[ "PFAM" ]

[ "PF11825" ]

[ "Nuc_recep-AF1" ]

[ 4221 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-383280", "R-BTA-5362517", "R-DRE-159418", "R-DRE-381340", "R-DRE-400206", "R-DRE-4090294", "R-DRE-5362517", "R-DRE-9616222", "R-DRE-9707564", "R-DRE-9841922", "R-HSA-1368108", "R-HSA-159418", "R-HSA-192105", "R-HSA-193368", "R-HSA-193807", "R-HSA-1989781", "R-HSA-200425", "R...

[ "REACTOME:R-BTA-383280", "REACTOME:R-BTA-5362517", "REACTOME:R-DRE-159418", "REACTOME:R-DRE-381340", "REACTOME:R-DRE-400206", "REACTOME:R-DRE-4090294", "REACTOME:R-DRE-5362517", "REACTOME:R-DRE-9616222", "REACTOME:R-DRE-9707564", "REACTOME:R-DRE-9841922", "REACTOME:R-HSA-1368108", "REACTOME:R-...

73

[ "3dzu", "3dzy", "3e00", "4nqa", "5uan" ]

5

[ "PUB00063250", "PUB00063251" ]

[ "12893880", "19321449" ]

[ "Activation functions 1 and 2 of nuclear receptors: molecular strategies for transcriptional activation.", "TIF1beta/KAP-1 is a coactivator of the orphan nuclear receptor NGFI-B/Nur77." ]

[ 2003, 2009 ]

2

[]

0

null

[ "Vertebrata" ]

[ 4221 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 33, 11, 8, 15 ]

4

true

Domain

Nuclear/hormone receptor activator site AF-1

Nuc_recep-AF1

5

IPR021782

21,782

Domain of unknown function DUF3347

DUF3347

Domain

3,795

false

This entry represents a functionally uncharacterised domain found in bacterial proteins.

[]

0

[ "PFAM" ]

[ "PF11827" ]

[ "DUF3347" ]

[ 3795 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Daphnia sinensis", "ecological metagenomes" ]

[ 3758, 2, 35 ]

3

[]

0

true

Domain

Domain of unknown function DUF3347

DUF3347

4

IPR021783

21,783

Protein of unknown function DUF3348

DUF3348

Family

1,055

false

This family of proteins are functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 244 to 323 amino acids in length.

[]

0

[ "PFAM" ]

[ "PF11828" ]

[ "DUF3348" ]

[ 1055 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Fungi", "Pseudomonadati", "metagenomes" ]

[ 2, 1048, 5 ]

3

[]

0

true

Family

Protein of unknown function DUF3348

DUF3348

6

IPR021784

21,784

Protein of unknown function DUF3349

DUF3349

Family

1,728

false

This family of proteins are functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 99 to 124 amino acids in length. According to literature, the DUF3349 proteins are predicted to be good drug targets because they are predominantly in the Mycobacterium and Rhodococ...

[]

0

[ "PFAM" ]

[ "PF11829" ]

[ "DUF3349" ]

[ 1728 ]

1

[]

0

[ "2kvc", "2lky", "2m0n", "3ol3", "3ol4" ]

5

[ "PUB00055118" ]

[ "21144816" ]

[ "Inaugural structure from the DUF3349 superfamily of proteins, Mycobacterium tuberculosis Rv0543c." ]

[ 2011 ]

1

[]

0

null

[ "Bacteria", "Rhynchospora breviuscula", "ecological metagenomes" ]

[ 1724, 1, 3 ]

3

[]

0

true

Family

Protein of unknown function DUF3349

DUF3349

5

IPR021786

21,786

Pre-mRNA splicing factor component Cdc5p/Cef1, C-terminal

Cdc5p/Cef1_C

Domain

4,653

false

This domain is found in Myb-Related Cdc5p/Cef1 proteins, which are part of the pre-mRNA splicing factor complex [ ].

[]

0

[ "PFAM" ]

[ "PF11831" ]

[ "Myb_Cef" ]

[ 4653 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-72163", "R-DDI-72163", "R-HSA-72163", "R-MMU-72163", "R-RNO-72163", "R-SPO-72163" ]

[ "REACTOME:R-BTA-72163", "REACTOME:R-DDI-72163", "REACTOME:R-HSA-72163", "REACTOME:R-MMU-72163", "REACTOME:R-RNO-72163", "REACTOME:R-SPO-72163" ]

6

[ "5lj3", "5lj5", "5lqw", "5mps", "5mq0", "5mqf", "5xjc", "5y88", "5ylz", "5yzg", "5z56", "5z57", "5z58", "6bk8", "6exn", "6ff4", "6ff7", "6icz", "6id0", "6id1", "6j6g", "6j6h", "6j6n", "6j6q", "6qdv", "6zym", "7a5p", "7aav", "7abg", "7abh", "7abi", "7b9v"...

58

[ "PUB00008533" ]

[ "11884590" ]

[ "Proteomics analysis reveals stable multiprotein complexes in both fission and budding yeasts containing Myb-related Cdc5p/Cef1p, novel pre-mRNA splicing factors, and snRNAs." ]

[ 2002 ]

1

[]

0

null

[ "Eukaryota" ]

[ 4653 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 2, 1, 5, 1, 3, 7, 1, 6, 3, 1, 1, 4 ]

12

true

Domain

Pre-mRNA splicing factor component Cdc5p/Cef1, C-terminal

Cdc5p/Cef1_C

7

IPR021787

21,787

Protein of unknown function DUF3352

DUF3352

Family

1,756

false

This family of proteins are functionally uncharacterised. This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 538 to 575 amino acids in length.

[]

0

[ "PFAM" ]

[ "PF11832" ]

[ "DUF3352" ]

[ 1756 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Sar", "metagenomes" ]

[ 1723, 6, 27 ]

3

[]

0

true

Family

Protein of unknown function DUF3352

DUF3352

1

IPR021788

21,788

Protein CHAPERONE-LIKE PROTEIN OF POR1-like

CPP1-like

Family

3,417

false

This entry includes proteins from plants and bacteria. The plant members CHAPERONE-LIKE PROTEIN OF POR1 (CPP1) and Protein CHLOROPLAST J-LIKE DOMAIN 1 (CJD1) have a J-like domain and three transmembrane domains. CPP1 is an essential protein for chloroplast development, plays a role in the regulation of POR (light-depen...

[]

0

[ "PFAM", "PANTHER" ]

[ "PF11833", "PTHR33372" ]

[ "CPP1-like", "" ]

[ 3233, 3259 ]

2

[]

0

[]

0

[ "PUB00074522", "PUB00100349", "PUB00100350", "PUB00100351" ]

[ "24151298", "24097264", "25901327", "22028775" ]

[ "Cell growth defect factor1/chaperone-like protein of POR1 plays a role in stabilization of light-dependent protochlorophyllide oxidoreductase in Nicotiana benthamiana and Arabidopsis.", "Plastidic protein Cdf1 is essential in Arabidopsis embryogenesis.", "Cell growth defect factor 1 is crucial for the plastid ...

[ 2013, 2014, 2015, 2011 ]

4

[]

0

null

[ "Cyanobacteriota", "Eukaryota" ]

[ 366, 3051 ]

2

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 17, 21, 31 ]

3

true

Family

Protein CHAPERONE-LIKE PROTEIN OF POR1-like

CPP1-like

7

IPR021789

21,789

KHA domain

KHA_dom

Domain

6,586

false

Potassium channels take part in important processes of higher plants, including opening and closing of stomatal pores and leaf movement. Inward rectifying potassium (K(+)in) channels play an important role in turgor regulation and ion uptake in higher plants. All of them comprise, from their N-terminal to their C-termi...

[]

0

[ "PFAM", "PROFILE" ]

[ "PF11834", "PS51490" ]

[ "KHA", "KHA" ]

[ 6525, 6429 ]

2

[]

0

[ "7cal", "7fcv", "7t4x", "7wm1", "7wm2", "7wsw", "7xuf", "8jec", "8jet", "8jeu", "8wfz", "8wtz", "8wui", "9is8", "9j0x", "9j0y", "9j0z", "9j10", "9khf", "9l9u", "9la0", "9la1", "9la2", "9la3", "9la7" ]

25

[ "PUB00054214", "PUB00054215", "PUB00054216" ]

[ "9202139", "9218788", "11849592" ]

[ "Association of plant K+(in) channels is mediated by conserved C-termini and does not affect subunit assembly.", "Tetramerization of the AKT1 plant potassium channel involves its C-terminal cytoplasmic domain.", "The K+ channel SKT1 is co-expressed with KST1 in potato guard cells--both channels can co-assemble ...

[ 1997, 1997, 2001 ]

3

[]

0

null

[ "Eukaryota" ]

[ 6586 ]

1

[ "Arabidopsis thaliana", "Danio rerio", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 49, 2, 5, 4, 18, 2, 76 ]

7

true

Domain

KHA domain

KHA_dom

1

IPR021790

21,790

PTBP1-like, RNA recognition motif 2

PTBP1-like_RRM2

Domain

13,525

false

This entry represents the RNA recognition motif 2 (RRM2) of polypyrimidine tract-binding protein 1 (PTBP1) and related proteins. Proteins containing this domain include PTBP1/2/3 (or PTB1/2/3) and heterogeneous nuclear ribonucleoprotein L-like (HNRNPLL) proteins. PTB can shuttle between nucleus and cytoplasm. It is a s...

[]

0

[ "PFAM" ]

[ "PF11835" ]

[ "RRM_8" ]

[ 13525 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-6803529", "R-BTA-72163", "R-BTA-72203", "R-HSA-6803529", "R-HSA-72163", "R-HSA-72203", "R-MMU-6803529", "R-MMU-72163", "R-MMU-72203", "R-RNO-6803529", "R-RNO-72163", "R-RNO-72203" ]

[ "REACTOME:R-BTA-6803529", "REACTOME:R-BTA-72163", "REACTOME:R-BTA-72203", "REACTOME:R-HSA-6803529", "REACTOME:R-HSA-72163", "REACTOME:R-HSA-72203", "REACTOME:R-MMU-6803529", "REACTOME:R-MMU-72163", "REACTOME:R-MMU-72203", "REACTOME:R-RNO-6803529", "REACTOME:R-RNO-72163", "REACTOME:R-RNO-72203"...

12

[ "1sjr", "2adb", "2e5i", "2mqm", "2mqp", "3zzy", "3zzz", "7evr", "7evs" ]

9

[ "PUB00077729", "PUB00077730", "PUB00084419", "PUB00084420" ]

[ "22575643", "25940628", "24264039", "24688880" ]

[ "A new function of ROD1 in nonsense-mediated mRNA decay.", "Generation of functionally distinct isoforms of PTBP3 by alternative splicing and translation initiation.", "New insights into functional roles of the polypyrimidine tract-binding protein.", "Solution and crystal structures of a C-terminal fragment o...

[ 2012, 2015, 2013, 2014 ]

4

[ "IPR000504" ]

[]

1

0

1

[ "Eukaryota" ]

[ 13525 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 23, 4, 21, 26, 41, 32, 56, 32, 35 ]

9

true

Domain

PTBP1-like, RNA recognition motif 2

PTBP1-like_RRM2

1

IPR021792

21,792

Beta-fructofuranosidase, N-terminal domain

Beta-fructofuranosidase_N

Domain

1,560

false

This entry represents the N-terminal domain of beta-fructofuranosidase (also known as vacuolar invertase) ( ), which is involved in the hydrolysis of terminal non-reducing beta-D-fructofuranoside residues in beta-D-fructofuranosides [ ].

[ "GO:0004564" ]

[ "beta-fructofuranosidase activity" ]

[ "molecular_function" ]

1

[ "PFAM" ]

[ "PF11837" ]

[ "INV_N" ]

[ 1560 ]

1

[ "EC", "METACYC" ]

[ "3.2.1.26", "PWY-8314" ]

[ "EC:3.2.1.26", "METACYC:PWY-8314" ]

2

[]

0

[ "PUB00098224" ]

[ "27083698" ]

[ "RhVI1 is a membrane-anchored vacuolar invertase highly expressed in Rosa hybrida L. petals." ]

[ 2016 ]

1

[]

0

null

[ "Spermatophyta" ]

[ 1560 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 10, 7, 11 ]

3

true

Domain

Beta-fructofuranosidase, N-terminal domain

Beta-fructofuranosidase_N

4

IPR021793

21,793

Major outer membrane lipoprotein Oprl

Oprl

Family

1,906

false

Oprl is a major outer membrane lipoprotein that contains an alanine-zipper [ , ]. Zipper motifs are a seven-repeat motif where the first and fourth positions are occupied by an aliphatic residue, usually a leucine. These residues are positioned on the outside of the coil such as to bind firmly to one or more monomers o...

[]

0

[ "PFAM" ]

[ "PF11839" ]

[ "Alanine_zipper" ]

[ 1906 ]

1

[]

0

[]

0

[ "PUB00078724", "PUB00078725" ]

[ "2473376", "2502533" ]

[ "Cloning and analysis of the gene for the major outer membrane lipoprotein from Pseudomonas aeruginosa.", "Pseudomonas aeruginosa outer membrane lipoprotein I gene: molecular cloning, sequence, and expression in Escherichia coli." ]

[ 1989, 1989 ]

2

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 34, 1739, 86, 16, 31 ]

5

[]

0

true

Family

Major outer membrane lipoprotein Oprl

Oprl

4

IPR021794

21,794

Protein of unknown function DUF3360

DUF3360

Family

889

false

This family of proteins are functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 489 to 517 amino acids in length.

[]

0

[ "PFAM" ]

[ "PF11840" ]

[ "DUF3360" ]

[ 889 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "marine sediment metagenome" ]

[ 886, 3 ]

2

[]

0

true

Family

Protein of unknown function DUF3360

DUF3360

1

IPR021795

21,795

Protein of unknown function DUF3363

DUF3363

Family

2,950

false

This family of proteins are functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 323 to 658 amino acids in length.

[]

0

[ "PFAM" ]

[ "PF11843" ]

[ "DUF3363" ]

[ 2950 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 2905, 10, 35 ]

3

[]

0

true

Family

Protein of unknown function DUF3363

DUF3363

4

IPR021796

21,796

Tll0287-like domain

Tll0287-like_dom

Domain

5,122

false

This domain covers the full length of Tll0287 from Thermosynechococcus vestitus ( ) and similar bacterial proteins. Tll0287 is a c-type haem protein that shows a β-sheet with four antiparallel β-strands surrounded by five α-helices. This structure is similar to some kinases and sensor proteins, but its specific functio...

[]

0

[ "PFAM" ]

[ "PF11845" ]

[ "Tll0287-like" ]

[ 5122 ]

1

[]

0

[ "5b82" ]

1

[ "PUB00100684" ]

[ "28428249" ]

[ "Crystal structure and redox properties of a novel cyanobacterial heme protein with a His/Cys heme axial ligation and a Per-Arnt-Sim (PAS)-like domain." ]

[ 2017 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "ecological metagenomes" ]

[ 4963, 2, 157 ]

3

[]

0

true

Domain

Tll0287-like domain

Tll0287-like_dom

4

IPR021797

21,797

Virulence factor membrane-bound polymerase, C-terminal

Wzy_C_2

Domain

2,336

false

Wzy is a membrane-bound polymerase of 12 TMs, found in Gram-positive bacteria such as Streptococcus pnuemoniae. It forms part of the EPS or exopolysaccharide system. This entry represents the 6xTMs at the C-terminal end of the molecule. Wzy functions in polymerising the oligosaccharide repeat subunits to form high-mole...

[]

0

[ "PFAM" ]

[ "PF11846" ]

[ "Wzy_C_2" ]

[ 2336 ]

1

[]

0

[]

0

[ "PUB00075665" ]

[ "18340341" ]

[ "The role of Streptococcus pneumoniae virulence factors in host respiratory colonization and disease." ]

[ 2008 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "ecological metagenomes" ]

[ 2315, 2, 19 ]

3

[]

0

true

Domain

Virulence factor membrane-bound polymerase, C-terminal

Wzy_C_2

4

IPR021798

21,798

Alpha-(1->3)-arabinofuranosyltransferase, N-terminal GT-C domain

AftD_N

Domain

2,139

false

This domain is found at the N-terminal of alpha-(1->3)- arabinofuranosyltransferase from Mycolicibacterium smegmatis (AftD, EC:2.4.2.47), which is involved in the biosynthesis of the arabinogalactan (AG) region of the mycolylarabinogalactan -peptidoglycan (mAGP) complex, an essential component of the mycobacterial cell...

[ "GO:0016740" ]

[ "transferase activity" ]

[ "molecular_function" ]

1

[ "PFAM" ]

[ "PF11847" ]

[ "GT-C_AftD" ]

[ 2139 ]

1

[]

0

[ "6w98", "6wbx", "6wby" ]

3

[ "PUB00086410", "PUB00155574" ]

[ "19654261", "32386575" ]

[ "AftD, a novel essential arabinofuranosyltransferase from mycobacteria.", "Cryo-EM Structures and Regulation of Arabinofuranosyltransferase AftD from Mycobacteria." ]

[ 2009, 2020 ]

2

[]

0

null

[ "Archaea", "Bacteria", "ecological metagenomes" ]

[ 6, 2067, 66 ]

3

[]

0

true

Domain

Alpha-(1->3)-arabinofuranosyltransferase, N-terminal GT-C domain

AftD_N

6

IPR021799

21,799

PIN-like domain, prokaryotic

PIN-like_prokaryotic

Family

4,681

false

This entry (ex DUF3368) represents a group of PIN domain proteins that cleave single-stranded RNA in a sequence- or structure-dependent manner. The PIN domain has a Rossmanoid fold with a central parallel β-sheet surrounded by α-helices.

[]

0

[ "PFAM" ]

[ "PF11848" ]

[ "DUF3368" ]

[ 4681 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Diploscapter pachys", "unclassified sequences" ]

[ 1102, 3449, 1, 129 ]

4

[]

0

true

Family

PIN-like domain, prokaryotic

PIN-like_prokaryotic

7

IPR021800

21,800

Domain of unknown function DUF3369

DUF3369

Domain

2,995

false

This domain is functionally uncharacterised. It is found in bacterial sequences, is around 170 amino acids in length, and may be related to the GAF domain.

[]

0

[ "PFAM" ]

[ "PF11849" ]

[ "DUF3369" ]

[ 2995 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 2979, 3, 13 ]

3

[]

0

true

Domain

Domain of unknown function DUF3369

DUF3369

1

IPR021801

21,801

Protein of unknown function DUF3370

DUF3370

Family

621

false

This family of proteins are functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 452 to 532 amino acids in length.

[]

0

[ "PFAM" ]

[ "PF11850" ]

[ "DUF3370" ]

[ 621 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria" ]

[ 621 ]

1

[]

0

true

Family

Protein of unknown function DUF3370

DUF3370

6

IPR021802

21,802

MiT/TFE transcription factors, C-terminal

MiT/TFE_C

Domain

5,744

false

This entry represents a domain found at the C terminus of the MiT/TFE family members, which include MITF (microphthalmia-associated transcription factor) and its related family members TFE3, TFEB and TFEC [ ]. They are basic helix-loop-helix leucine zipper transcription factors found in chordata. These transcription fa...

[ "GO:0006355" ]

[ "regulation of DNA-templated transcription" ]

[ "biological_process" ]

1

[ "PFAM" ]

[ "PF11851" ]

[ "DUF3371" ]

[ 5744 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-3232118", "R-HSA-9824585", "R-HSA-9824594", "R-HSA-9825892", "R-HSA-9825895", "R-HSA-9854907", "R-HSA-9854909", "R-HSA-9856649", "R-HSA-9857377", "R-HSA-9926550", "R-HSA-9931510", "R-MMU-3232118", "R-MMU-9824594", "R-MMU-9856649", "R-RNO-3232118", "R-RNO-9824594", "R-RNO-98566...

[ "REACTOME:R-HSA-3232118", "REACTOME:R-HSA-9824585", "REACTOME:R-HSA-9824594", "REACTOME:R-HSA-9825892", "REACTOME:R-HSA-9825895", "REACTOME:R-HSA-9854907", "REACTOME:R-HSA-9854909", "REACTOME:R-HSA-9856649", "REACTOME:R-HSA-9857377", "REACTOME:R-HSA-9926550", "REACTOME:R-HSA-9931510", "REACTOM...

17

[ "7ux2", "7uxc", "7uxh" ]

3

[ "PUB00055428", "PUB00055432", "PUB00076471" ]

[ "15507434", "7958932", "26240184" ]

[ "Sumoylation of MITF and its related family members TFE3 and TFEB.", "microphthalmia, a critical factor in melanocyte development, defines a discrete transcription factor family.", "MiT/TFE transcription factors are activated during mitophagy downstream of Parkin and Atg5." ]

[ 2005, 1994, 2015 ]

3

[]

0

null

[ "Deuterostomia" ]

[ 5744 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 41, 15, 17, 18 ]

4

true

Domain

MiT/TFE transcription factors, C-terminal

MiT/TFE_C

1

IPR021803

21,803

Protein of unknown function DUF3373

DUF3373

Family

451

false

This family of proteins are functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 472 to 574 amino acids in length.

[]

0

[ "PFAM" ]

[ "PF11853" ]

[ "DUF3373" ]

[ 451 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "ecological metagenomes" ]

[ 434, 17 ]

2

[]

0

true

Family

Protein of unknown function DUF3373

DUF3373

2

IPR021804

21,804

Protein of unknown function DUF3375

DUF3375

Family

2,820

false

This family of proteins are functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 479 to 499 amino acids in length.

[]

0

[ "PFAM" ]

[ "PF11855" ]

[ "DUF3375" ]

[ 2820 ]

1

[]

0

[ "8as8", "8bfn", "8dk1", "8dk2", "8dk3", "8q72", "9qxr", "9qxs", "9qxt", "9qxu", "9qxv", "9qxx" ]

12

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Methanosarcinales", "unclassified sequences" ]

[ 2773, 7, 6, 34 ]

4

[]

0

true

Family

Protein of unknown function DUF3375

DUF3375

1

IPR021805

21,805

Peptidase M10A, matrix metallopeptidase, C-terminal

Pept_M10A_metallopeptidase_C

Domain

4,632

false

This domain is functionally uncharacterised and found at the C terminus of peptidases belonging to MEROPS peptidase family M10A, membrane-type matrix metallopeptidases (clan MA).

[ "GO:0004222" ]

[ "metalloendopeptidase activity" ]

[ "molecular_function" ]

1

[ "PFAM" ]

[ "PF11857" ]

[ "DUF3377" ]

[ 4632 ]

1

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "3.4.24", "R-HSA-1442490", "R-HSA-1474228", "R-HSA-1592389", "R-HSA-9839383", "R-HSA-9856530", "R-MMU-1442490", "R-MMU-1474228", "R-MMU-1592389", "R-MMU-9839383", "R-RNO-1442490", "R-RNO-1474228", "R-RNO-1592389", "R-RNO-9839383" ]

[ "EC:3.4.24", "REACTOME:R-HSA-1442490", "REACTOME:R-HSA-1474228", "REACTOME:R-HSA-1592389", "REACTOME:R-HSA-9839383", "REACTOME:R-HSA-9856530", "REACTOME:R-MMU-1442490", "REACTOME:R-MMU-1474228", "REACTOME:R-MMU-1592389", "REACTOME:R-MMU-9839383", "REACTOME:R-RNO-1442490", "REACTOME:R-RNO-14742...

14

[ "3x23" ]

1

[]

0

[]

0

null

[ "Eukaryota" ]

[ 4632 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 11, 9, 9, 12 ]

4

true

Domain

Peptidase M10A, matrix metallopeptidase, C-terminal

Pept_M10A_metallopeptidase_C

3

IPR021806

21,806

Protein of unknown function DUF3379

DUF3379

Family

860

false

This family of proteins are functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 234 to 251 amino acids in length.

[]

0

[ "PFAM" ]

[ "PF11859" ]

[ "DUF3379" ]

[ 860 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "ecological metagenomes" ]

[ 849, 11 ]

2

[]

0

true

Family

Protein of unknown function DUF3379

DUF3379

8

IPR021807

21,807

High-affinity branched-chain amino acid transport system permease, LivHM, N-terminal

LivHM_N

Domain

4,997

false

This entry represents the N-terminal domain of the LivHM type high-affinity branched-chain amino acid transport system permease proteins. The domain is about 100 amino acids in length, and is found associated with .

[]

0

[ "PFAM" ]

[ "PF11862" ]

[ "DUF3382" ]

[ 4997 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 4977, 4, 16 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Domain

High-affinity branched-chain amino acid transport system permease, LivHM, N-terminal

LivHM_N

1

IPR021808

21,808

Protein of unknown function DUF3383

DUF3383

Family

2,613

false

This family of proteins are functionally uncharacterised. This protein is found in bacteria and viruses. Proteins in this family are typically between 356 to 501 amino acids in length.

[]

0

[ "PFAM" ]

[ "PF11863" ]

[ "DUF3383" ]

[ 2613 ]

1

[]

0

[ "7kh1", "7kjk", "8env", "8fuv", "8fvg", "8hdr", "8hdw", "9b42", "9c39", "9c3b" ]

10

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Viruses", "metagenomes" ]

[ 1932, 13, 650, 18 ]

4

[]

0

true

Family

Protein of unknown function DUF3383

DUF3383

1

IPR021809

21,809

Protein of unknown function DUF3386

DUF3386

Family

510

false

This family of proteins are functionally uncharacterised. This protein is found in bacteria and eukaryotes. Proteins in this family are about 220 amino acids in length.

[]

0

[ "PFAM" ]

[ "PF11866" ]

[ "DUF3386" ]

[ 510 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "marine metagenome" ]

[ 506, 4 ]

2

[]

0

true

Family

Protein of unknown function DUF3386

DUF3386

1

IPR021810

21,810

Type I restriction enzyme HindI endonuclease subunit-like, C-terminal

T1RH-like_C

Domain

6,301

false

This domain is found at the C-terminal of Type I restriction enzyme HindI endonuclease subunit (also known as R protein) from Haemophilus influenzae and related sequences from bacteria and archaea [ ]. This domain is typically between 255 to 340 amino acids in length and its function is unknown. This domain is found as...

[]

0

[ "PFAM" ]

[ "PF11867" ]

[ "T1RH-like_C" ]

[ 6301 ]

1

[]

0

[]

0

[ "PUB00099965" ]

[ "12654995" ]

[ "A nomenclature for restriction enzymes, DNA methyltransferases, homing endonucleases and their genes." ]

[ 2003 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 283, 5870, 6, 142 ]

4

[]

0

true

Domain

Type I restriction enzyme HindI endonuclease subunit-like, C-terminal

T1RH-like_C

6

IPR021811

21,811

Protein of unknown function DUF3389

DUF3389

Family

412

false

This family of proteins are functionally uncharacterised. This protein is found in bacteria. Proteins in this family are about 80 amino acids in length.

[]

0

[ "PFAM" ]

[ "PF11869" ]

[ "DUF3389" ]

[ 412 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria" ]

[ 412 ]

1

[]

0

true

Family

Protein of unknown function DUF3389

DUF3389

9

IPR021812

21,812

Domain of unknown function DUF3391

DUF3391

Domain

5,163

false

This functionally uncharacterised, N-terminal domain is found in a number of bacterial proteins, including Cyclic di-GMP phosphodiesterase PA4108. It is often found associated with the HD domain .

[]

0

[ "PFAM" ]

[ "PF11871" ]

[ "DUF3391" ]

[ 5163 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 5104, 6, 53 ]

3

[]

0

true

Domain

Domain of unknown function DUF3391

DUF3391

4

IPR021813

21,813

Protein of unknown function DUF3392

DUF3392

Family

1,172

false

This family of proteins are functionally uncharacterised. This protein is found in bacteria. Proteins in this family are about 110 amino acids in length.

[]

0

[ "PFAM" ]

[ "PF11872" ]

[ "DUF3392" ]

[ 1172 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "metagenomes" ]

[ 1167, 5 ]

2

[]

0

true

Family

Protein of unknown function DUF3392

DUF3392

6

IPR021814

21,814

Protein of unknown function DUF3394

DUF3394

Family

2,396

false

This domain is functionally uncharacterised. This domain is found in bacteria. This presumed domain is about 190 amino acids in length. This domain is found associated with .

[]

0

[ "PFAM" ]

[ "PF11874" ]

[ "DUF3394" ]

[ 2396 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Halalkalicoccus paucihalophilus", "unclassified sequences" ]

[ 2338, 4, 1, 53 ]

4

[]

0

true

Family

Protein of unknown function DUF3394

DUF3394

4

IPR021815

21,815

Type VI immunity for VRR-NUC

TsiV

Family

1,747

false

This entry represents bacterial immunity proteins that in are encoded by the PAAR2 cluster [ ] and have been named Type VI immunity for VRR-NUC (TsiV). These proteins form an effector-immunity pair with TseV (type VI effector VRR-NUC), the TseV-TsiV pair [ , ]. These are α+β class of proteins whose surface is mainly el...

[]

0

[ "PFAM" ]

[ "PF11876" ]

[ "TsiV" ]

[ 1747 ]

1

[]

0

[ "7drg" ]

1

[ "PUB00103836", "PUB00103837" ]

[ "36226828", "33838074" ]

[ "Antibacterial T6SS effectors with a VRR-Nuc domain are structure-specific nucleases.", "The Pseudomonas aeruginosa PAAR2 cluster encodes a putative VRR-NUC domain-containing effector." ]

[ 2022, 2021 ]

2

[]

0

null

[ "Bacteria", "Caudoviricetes", "Physcomitrium patens", "ecological metagenomes" ]

[ 1735, 9, 1, 2 ]

4

[]

0

true

Family

Type VI immunity for VRR-NUC

TsiV

4

IPR021816

21,816

Dedicator of cytokinesis C/D, N-terminal

DOCK_C/D_N

Domain

13,395

false

DOCK family members are evolutionarily conserved guanine nucleotide exchange factors (GEFs) for Rho-family GTPases [ ]. DOCK proteins are required during several cellular processes, such as cell motility and phagocytosis. The N-terminal SH3 domain of the DOCK proteins functions as an inhibitor of GEF, which can be reli...

[]

0

[ "PFAM" ]

[ "PF11878" ]

[ "DOCK_C-D_N" ]

[ 13395 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-8875555", "R-HSA-9013148", "R-HSA-9013149", "R-HSA-9013404", "R-HSA-9013409", "R-HSA-9013423", "R-HSA-983231", "R-MMU-8875555", "R-MMU-9013148", "R-MMU-9013149", "R-MMU-9013404", "R-MMU-9013409", "R-MMU-9013423", "R-MMU-983231" ]

[ "REACTOME:R-HSA-8875555", "REACTOME:R-HSA-9013148", "REACTOME:R-HSA-9013149", "REACTOME:R-HSA-9013404", "REACTOME:R-HSA-9013409", "REACTOME:R-HSA-9013423", "REACTOME:R-HSA-983231", "REACTOME:R-MMU-8875555", "REACTOME:R-MMU-9013148", "REACTOME:R-MMU-9013149", "REACTOME:R-MMU-9013404", "REACTOME...

14

[]

0

[ "PUB00014935", "PUB00073862", "PUB00073863" ]

[ "12432077", "15723800", "25022758" ]

[ "Identification of an evolutionarily conserved superfamily of DOCK180-related proteins with guanine nucleotide exchange activity.", "A Steric-inhibition model for regulation of nucleotide exchange via the Dock180 family of GEFs.", "Dock-family exchange factors in cell migration and disease." ]

[ 2002, 2005, 2014 ]

3

[]

0

null

[ "Eukaryota" ]

[ 13395 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 3, 92, 10, 39, 27, 35 ]

6

true

Domain

Dedicator of cytokinesis C/D, N-terminal

DOCK_C/D_N

4

IPR021817

21,817

Protein of unknown function DUF3400

DUF3400

Family

1,764

false

This domain is functionally uncharacterised. This domain is found in bacteria. This presumed domain is about 50 amino acids in length. This domain is found associated with , , .

[]

0

[ "PFAM" ]

[ "PF11880" ]

[ "DUF3400" ]

[ 1764 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Pseudomonadati", "Steinernema glaseri", "unclassified sequences" ]

[ 1705, 1, 58 ]

3

[]

0

true

Family

Protein of unknown function DUF3400

DUF3400

9

IPR021818

21,818

Signal-induced proliferation-associated 1-like protein, C-terminal

SIPA1L_C

Domain

4,541

false

This domain is found in C-terminal of the signal-induced proliferation-associated 1-like (SIPA1L) proteins, including SIPA1L 1-3 from humans. SIPA1Ls shares protein sequence similarity with signal-induced proliferation-associated protein 1 (SIPA1), which is a GTPase activator for the nuclear Ras-related regulatory prot...

[]

0

[ "PFAM" ]

[ "PF11881" ]

[ "SPAR_C" ]

[ 4541 ]

1

[ "REACTOME" ]

[ "R-HSA-6794361" ]

[ "REACTOME:R-HSA-6794361" ]

1

[]

0

[ "PUB00018099", "PUB00073404", "PUB00073405" ]

[ "9346962", "15310461", "11502259" ]

[ "Human SPA-1 gene product selectively expressed in lymphoid tissues is a specific GTPase-activating protein for Rap1 and Rap2. Segregate expression profiles from a rap1GAP gene product.", "Rap1 and SPA-1 in hematologic malignancy.", "Regulation of dendritic spine morphology by SPAR, a PSD-95-associated RapGAP."...

[ 1997, 2004, 2001 ]

3

[]

0

null

[ "Bilateria" ]

[ 4541 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 46, 12, 18, 19 ]

4

true

Domain

Signal-induced proliferation-associated 1-like protein, C-terminal

SIPA1L_C

8

IPR021819

21,819

Far11/STRP, C-terminal

Far11/STRP_C

Domain

5,275

false

This domain can be found in the C terminus of the yeast Far11 protein and the human STRP1/2 proteins. Budding yeast Far11 interacts with the phosphatases Pph21, Pph22, and Pph3 and may be involved in the regulation of autophagy and the DNA damage signaling [ ]. STRP1/2 (also known as FAM40A/B) are regulators of cytoske...

[]

0

[ "PFAM", "SMART" ]

[ "PF11882", "SM01293" ]

[ "DUF3402", "DUF3402" ]

[ 5272, 5155 ]

2

[]

0

[ "7k36" ]

1

[ "PUB00063300", "PUB00086409" ]

[ "21834987", "22782902" ]

[ "Identification and characterization of a set of conserved and new regulators of cytoskeletal organization, cell morphology and migration.", "The protein factor-arrest 11 (Far11) is essential for the toxicity of human caspase-10 in yeast and participates in the regulation of autophagy and the DNA damage signaling...

[ 2011, 2012 ]

2

[]

0

null

[ "Eukaryota" ]

[ 5275 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strai...

[ 3, 9, 2, 6, 5, 2, 5, 1, 1 ]

9

true

Domain

Far11/STRP, C-terminal

Far11/STRP_C

6

IPR021820

21,820

S-locus receptor kinase, C-terminal

S-locus_recpt_kinase_C

Domain

10,032

false

This functionally uncharacterised domain of around 50 amino acids is found in the C terminus of S-locus receptor kinase proteins from plants [ ].

[ "GO:0004674" ]

[ "protein serine/threonine kinase activity" ]

[ "molecular_function" ]

1

[ "PFAM" ]

[ "PF11883" ]

[ "DUF3403" ]

[ 10032 ]

1

[ "EC" ]

[ "2.7.11.1" ]

[ "EC:2.7.11.1" ]

1

[]

0

[ "PUB00075427" ]

[ "8811866" ]

[ "An S-locus-related gene in Arabidopsis encodes a functional kinase and produces two classes of transcripts." ]

[ 1996 ]

1

[]

0

null

[ "Magnoliopsida" ]

[ 10032 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 118, 18, 18 ]

3

true

Domain

S-locus receptor kinase, C-terminal

S-locus_recpt_kinase_C

4

IPR021821

21,821

Histidine kinase VxrA, sensor domain

VxrA_SD

Domain

537

false

This entry represents bacterial periplasmic sensor domains of histidine kinase VxrA and related proteins. VxrA is a component in two-component systems (TCSs) that sense fluctuating environmental conditions and elicit the appropriate cellular response. VxrA has a periplasmic sensor domain that is flanked by transmembran...

[]

0

[ "PFAM" ]

[ "PF11884" ]

[ "DUF3404" ]

[ 537 ]

1

[]

0

[ "4r7q", "7cjr", "7cus", "7f2g", "7f2h", "7kb3", "7kb7", "7kb9", "7la6" ]

9

[ "PUB00103912" ]

[ "33753465" ]

[ "Sensor Domain of Histidine Kinase VxrA of Vibrio cholerae- A Hairpin-swapped Dimer and its Conformational Change." ]

[ 2021 ]

1

[]

0

null

[ "Bacteria", "Beauveria bassiana D1-5", "marine metagenome" ]

[ 535, 1, 1 ]

3

[]

0

true

Domain

Histidine kinase VxrA, sensor domain

VxrA_SD

6

IPR021822

21,822

Protein of unknown function DUF3405

DUF3405

Family

3,411

false

This family of proteins are functionally uncharacterised. This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 636 to 810 amino acids in length.

[]

0

[ "PFAM", "PANTHER" ]

[ "PF11885", "PTHR36205" ]

[ "DUF3405", "" ]

[ 3406, 3366 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Eukaryota", "Pseudomonadati", "metagenomes" ]

[ 3393, 16, 2 ]

3

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)" ]

[ 4 ]

1

true

Family

Protein of unknown function DUF3405

DUF3405

8

IPR021823

21,823

Protein of unknown function DUF3408

DUF3408

Family

4,090

false

This family of proteins are functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 128 to 160 amino acids in length.

[]

0

[ "PFAM" ]

[ "PF11888" ]

[ "DUF3408" ]

[ 4090 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "metagenomes", "unclassified Caudoviricetes" ]

[ 3982, 106, 2 ]

3

[]

0

true

Family

Protein of unknown function DUF3408

DUF3408

1

IPR021824

21,824

Capsid protein C, pestivirus

Capsid-C_pestivirus

Domain

885

false

This domain is found in the genome polyprotein from Pestivirus. This domain covers part of the capsid protein C region in the polyprotein.

[ "GO:0003968", "GO:0004197", "GO:0004252", "GO:0016817", "GO:0017111", "GO:0070008" ]

[ "RNA-directed RNA polymerase activity", "cysteine-type endopeptidase activity", "serine-type endopeptidase activity", "hydrolase activity, acting on acid anhydrides", "ribonucleoside triphosphate phosphatase activity", "serine-type exopeptidase activity" ]

[ "molecular_function", "molecular_function", "molecular_function", "molecular_function", "molecular_function", "molecular_function" ]

6

[ "PFAM" ]

[ "PF11889" ]

[ "Capsid_pestivir" ]

[ 885 ]

1

[ "EC", "EC", "EC", "EC", "EC", "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC" ]

[ "2.7.7.48", "3.4.21.113", "3.4.22.-", "3.6.1.15", "3.6.4.13", "4.6.1.19", "PWY-6545", "PWY-7184", "PWY-7185", "PWY-7198", "PWY-7210" ]

[ "EC:2.7.7.48", "EC:3.4.21.113", "EC:3.4.22.-", "EC:3.6.1.15", "EC:3.6.4.13", "EC:4.6.1.19", "METACYC:PWY-6545", "METACYC:PWY-7184", "METACYC:PWY-7185", "METACYC:PWY-7198", "METACYC:PWY-7210" ]

11

[]

0

[]

0

[]

0

null

[ "Orthornavirae" ]

[ 885 ]

1

[]

0

true

Domain

Capsid protein C, pestivirus

Capsid-C_pestivirus

7

IPR021825

21,825

Protein RETICULATA-related

RETICULATA-related

Family

5,244

false

This entry represents RETICULATA and related proteins from plants. Arabidopsis RETICULATA protein is involved in differential development of bundle sheath and mesophyll cell chloroplasts [ ].

[]

0

[ "PFAM" ]

[ "PF11891" ]

[ "RETICULATA-like" ]

[ 5244 ]

1

[]

0

[]

0

[ "PUB00075342" ]

[ "9550714" ]

[ "Bundle sheath cells and cell-specific plastid development in Arabidopsis leaves." ]

[ 1998 ]

1

[]

0

null

[ "Eukaryota" ]

[ 5244 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 33, 29, 45 ]

3

true

Family

Protein RETICULATA-related

RETICULATA-related

3

IPR021826

21,826

Pyrimidine/purine nucleotide 5'-monophosphate nucleosidase, C-terminal domain

PpnN_C

Domain

4,182

false

This entry represents a domain found at the C-terminal end of Pyrimidine/purine nucleotide 5'-monophosphate nucleosidase from Escherichia coli (PpnN, also known as YgdH) and similar proteins mainly found in gammaproteobacteria. PpnN is a nucleosidase that catalyses the hydrolysis of the N-glycosidic bond of diverse pyr...

[]

0

[ "PFAM" ]

[ "PF11892" ]

[ "PpnN_C" ]

[ 4182 ]

1

[ "EC", "EC", "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC" ]

[ "3.2.2.-", "3.2.2.10", "3.2.2.4", "PWY-2681", "PWY-5316", "PWY-5381", "PWY-6617", "PWY-7342", "PWY-7564", "PWY-7569", "PWY-7570", "PWY-8106" ]

[ "EC:3.2.2.-", "EC:3.2.2.10", "EC:3.2.2.4", "METACYC:PWY-2681", "METACYC:PWY-5316", "METACYC:PWY-5381", "METACYC:PWY-6617", "METACYC:PWY-7342", "METACYC:PWY-7564", "METACYC:PWY-7569", "METACYC:PWY-7570", "METACYC:PWY-8106" ]

12

[ "2pmb", "3bq9", "3gh1", "4npa", "6gfl", "6gfm", "9hs1", "9hs2", "9hs3" ]

9

[ "PUB00084997", "PUB00100958" ]

[ "27941785", "31023582" ]

[ "Nontargeted in vitro metabolomics for high-throughput identification of novel enzymes in Escherichia coli.", "(p)ppGpp Regulates a Bacterial Nucleosidase by an Allosteric Two-Domain Switch." ]

[ 2017, 2019 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 4127, 7, 48 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Domain

Pyrimidine/purine nucleotide 5'-monophosphate nucleosidase, C-terminal domain

PpnN_C

7

IPR021827

21,827

Nucleoporin Nup186/Nup192/Nup205

Nup186/Nup192/Nup205

Family

8,422

false

Proteins in this family are components of the nuclear pore complex (NPC). These protein are called nucleoporins (NUPs), which can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. This entry includes Nup186/Nup192/Nup205. In budd...

[ "GO:0005643" ]

[ "nuclear pore" ]

[ "cellular_component" ]

1

[ "PFAM", "PANTHER" ]

[ "PF11894", "PTHR31344" ]

[ "Nup192", "" ]

[ 5682, 8077 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-DME-159227", "R-DME-159230", "R-DME-159231", "R-DME-159236", "R-DME-170822", "R-DME-3108214", "R-DME-3301854", "R-DME-4085377", "R-DME-4551638", "R-DME-4615885", "R-DME-5578749", "R-DME-9615933", "R-HSA-1169408", "R-HSA-159227", "R-HSA-159230", "R-HSA-159231", "R-HSA-159236", "R...

[ "REACTOME:R-DME-159227", "REACTOME:R-DME-159230", "REACTOME:R-DME-159231", "REACTOME:R-DME-159236", "REACTOME:R-DME-170822", "REACTOME:R-DME-3108214", "REACTOME:R-DME-3301854", "REACTOME:R-DME-4085377", "REACTOME:R-DME-4551638", "REACTOME:R-DME-4615885", "REACTOME:R-DME-5578749", "REACTOME:R-D...

57

[ "4ifq", "4knh", "5cwv", "5hb4", "5ijn", "5ijo", "6lk8", "7fik", "7mvt", "7mvu", "7mvv", "7n85", "7n9f", "7per", "7r5j", "7r5k", "7tbi", "7tbj", "7tbk", "7tbl", "7tbm", "7tdz", "7vci", "7vop", "7wb4", "7wkk", "7woo", "7wot", "8tj5", "9hcj", "9sob" ]

31

[ "PUB00057985", "PUB00063169" ]

[ "15703211", "10428845" ]

[ "Vertebrate Nup53 interacts with the nuclear lamina and is required for the assembly of a Nup93-containing complex.", "Nup192p is a conserved nucleoporin with a preferential location at the inner site of the nuclear membrane." ]

[ 2005, 1999 ]

2

[]

0

null

[ "Eukaryota" ]

[ 8422 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 40, 1, 4, 5, 7, 10, 1, 13, 3, 1, 1, 66 ]

12

true

Family

Nucleoporin Nup186/Nup192/Nup205

Nup186/Nup192/Nup205

6

IPR021828

21,828

Alpha-1,4-glucan:maltose-1-phosphate maltosyltransferase, domain N/S

GlgE_dom_N/S

Domain

7,612

false

This entry represents domain N and S of GlgE.

[ "GO:0004553" ]

[ "hydrolase activity, hydrolyzing O-glycosyl compounds" ]

[ "molecular_function" ]

1

[ "PFAM" ]

[ "PF11896" ]

[ "GlgE_dom_N_S" ]

[ 7612 ]

1

[ "EC", "METACYC" ]

[ "2.4.99.16", "PWY-7900" ]

[ "EC:2.4.99.16", "METACYC:PWY-7900" ]

2

[ "3zss", "3zst", "3zt5", "3zt6", "3zt7", "4cn1", "4cn4", "4cn6", "4u2y", "4u2z", "4u31", "4u33", "4u3c", "5cgm", "5cim", "5cj5", "5cvs", "5lgv", "5lgw", "5vsj", "5vt4", "7mel", "7mgy", "7uvd", "8d6k" ]

25

[ "PUB00017702", "PUB00060749", "PUB00060751" ]

[ "11257505", "21914799", "9302327" ]

[ "Relationship of sequence and structure to specificity in the alpha-amylase family of enzymes.", "Structure of Streptomyces maltosyltransferase GlgE, a homologue of a genetically validated anti-tuberculosis target.", "Domain evolution in the alpha-amylase family." ]

[ 2001, 2011, 1997 ]

3

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "metagenomes" ]

[ 21, 7498, 7, 86 ]

4

[]

0

true

Domain

Alpha-1,4-glucan:maltose-1-phosphate maltosyltransferase, domain N/S

GlgE_dom_N/S

4

IPR021829

21,829

Protein of unknown function DUF3419

DUF3419

Family

3,424

false

This family of proteins are functionally uncharacterised. This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 398 to 802 amino acids in length.

[]

0

[ "PFAM" ]

[ "PF11899" ]

[ "DUF3419" ]

[ 3424 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Mimiviridae", "unclassified sequences" ]

[ 1597, 1803, 6, 18 ]

4

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)" ]

[ 1 ]

1

true

Family

Protein of unknown function DUF3419

DUF3419

8

IPR021830

21,830

Protein of unknown function DUF3422

DUF3422

Family

3,433

false

This family of proteins are functionally uncharacterised. This protein is found in bacteria, archaea and eukaryotes. Proteins in this family are typically between 426 to 444 amino acids in length.

[]

0

[ "PFAM" ]

[ "PF11902" ]

[ "DUF3422" ]

[ 3433 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Methanococcus aeolicus (strain ATCC BAA-1280 / DSM 17508 / OCM 812 / Nankai-3)", "ecological metagenomes" ]

[ 3345, 58, 1, 29 ]

4

[]

0

true

Family

Protein of unknown function DUF3422

DUF3422

6

IPR021831

21,831

ParD-like antitoxin of type II bacterial toxin-antitoxin system

ParD-like

Family

3,383

false

ParD-like antitoxin is a family of archaeal and bacterial proteins of a type II bacterial toxin-antitoxin system. Many of the cognate toxins for these molecules fall into family ParE-like_toxin, . Gene-pairs are expressed from the same operon, the toxin of the pair being expressed first, eg, for and .

[]

0

[ "PFAM" ]

[ "PF11903" ]

[ "ParD_like" ]

[ 3383 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Opisthokonta", "metagenomes", "uncultured Poseidoniia archaeon" ]

[ 3315, 5, 62, 1 ]

4

[]

0

true

Family

ParD-like antitoxin of type II bacterial toxin-antitoxin system

ParD-like

8

IPR021833

21,833

Protein of unknown function DUF3425

DUF3425

Family

10,268

false

This presumed domain is functionally uncharacterised. This domain is found in eukaryotes. This domain is typically between 120 to 143 amino acids in length.

[]

0

[ "PFAM" ]

[ "PF11905" ]

[ "DUF3425" ]

[ 10268 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Eukaryota" ]

[ 10268 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)" ]

[ 1 ]

1

true

Family

Protein of unknown function DUF3425

DUF3425

3

IPR021835

21,835

Domain of unknown function DUF3427

DUF3427

Domain

4,275

false

This presumed domain is functionally uncharacterised. This domain is found in bacteria and archaea. This domain is typically between 243 to 275 amino acids in length. This domain is found associated with , in some members.

[]

0

[ "PFAM" ]

[ "PF11907" ]

[ "DUF3427" ]

[ 4275 ]

1

[]

0

[ "7clg" ]

1

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 62, 4163, 3, 47 ]

4

[]

0

true

Domain

Domain of unknown function DUF3427

DUF3427

7

IPR021836

21,836

Protein of unknown function DUF3429

DUF3429

Family

5,147

false

This family of proteins are functionally uncharacterised. This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 147 to 245 amino acids in length.

[]

0

[ "PFAM", "PANTHER" ]

[ "PF11911", "PTHR15887" ]

[ "DUF3429", "" ]

[ 5127, 4383 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 2583, 2542, 22 ]

3

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus" ]

[ 1, 1, 1, 1, 2 ]

5

true

Family

Protein of unknown function DUF3429

DUF3429

2

IPR021837

21,837

Counting factor-associated protein A/B/C

CfaA/B/C

Family

249

false

Developing Dictyostelium (Slime mold) cells form large aggregation streams that break up into groups of cells. Each group then becomes a fruiting body. Cells sense if there are too many cells in a stream by sensing the concentration of counting factor (CF), a protein complex secreted by the aggregating cells [ ]. This ...

[]

0

[ "PFAM" ]

[ "PF11912" ]

[ "CfaA_B_C" ]

[ 249 ]

1

[]

0

[]

0

[ "PUB00088382" ]

[ "10444594" ]

[ "A cell-counting factor regulating structure size in Dictyostelium." ]

[ 1999 ]

1

[]

0

null

[ "Eukaryota" ]

[ 249 ]

1

[]

0

true

Family

Counting factor-associated protein A/B/C

CfaA/B/C

7

IPR021839

21,839

Early growth response protein 1, C-terminal

EGR1_C

Repeat

1,353

false

EGR1 is a transcriptional regulator that binds specifically to 9-bp target sequences containing two CpG sites that can potentially be methylated at four cytosine bases [ ].

[]

0

[ "PFAM" ]

[ "PF11914" ]

[ "DUF3432" ]

[ 1353 ]

1

[ "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-8943724", "R-HSA-9031628", "R-HSA-909733" ]

[ "REACTOME:R-HSA-8943724", "REACTOME:R-HSA-9031628", "REACTOME:R-HSA-909733" ]

3

[]

0

[ "PUB00086408" ]

[ "25999311" ]

[ "Structural impact of complete CpG methylation within target DNA on specific complex formation of the inducible transcription factor Egr-1." ]

[ 2015 ]

1

[]

0

null

[ "Bacillati", "Eukaryota" ]

[ 2, 1351 ]

2

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 4, 5, 3 ]

4

true

Repeat

Early growth response protein 1, C-terminal

EGR1_C

7

IPR021840

21,840

Protein of unknown function DUF3433

DUF3433

Family

6,411

false

This family of proteins are functionally uncharacterised. This protein is found in eukaryotes. Proteins in this family are typically between 784 to 1240 amino acids in length.

[]

0

[ "PFAM" ]

[ "PF11915" ]

[ "DUF3433" ]

[ 6411 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Eukaryota" ]

[ 6411 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)" ]

[ 5 ]

1

true

Family

Protein of unknown function DUF3433

DUF3433

5

IPR021841

21,841

Vacuolar protein 14, C-terminal Fig4-binding domain

VAC14_Fig4p-bd

Domain

5,463

false

Vac14 is a scaffold for the Fab1 kinase complex, a complex that allows for the dynamic interconversion of PI3P and PI(3,5)P2p (phosphoinositide phosphate (PIP) lipids, that are generated transiently on the cytoplasmic face of selected intracellular membranes) [ ]. This interconversion is regulated by at least five prot...

[]

0

[ "PFAM" ]

[ "PF11916" ]

[ "Vac14_Fig4_bd" ]

[ 5463 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-1660514", "R-HSA-1660516", "R-HSA-1660517", "R-MMU-1660514", "R-MMU-1660516", "R-MMU-1660517", "R-RNO-1660514", "R-RNO-1660516", "R-RNO-1660517" ]

[ "REACTOME:R-HSA-1660514", "REACTOME:R-HSA-1660516", "REACTOME:R-HSA-1660517", "REACTOME:R-MMU-1660514", "REACTOME:R-MMU-1660516", "REACTOME:R-MMU-1660517", "REACTOME:R-RNO-1660514", "REACTOME:R-RNO-1660516", "REACTOME:R-RNO-1660517" ]

9

[]

0

[ "PUB00061897", "PUB00061898" ]

[ "19037259", "17956977" ]

[ "VAC14 nucleates a protein complex essential for the acute interconversion of PI3P and PI(3,5)P(2) in yeast and mouse.", "Loss of Vac14, a regulator of the signaling lipid phosphatidylinositol 3,5-bisphosphate, results in neurodegeneration in mice." ]

[ 2008, 2007 ]

2

[]

0

null

[ "Eukaryota" ]

[ 5463 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 5, 1, 3, 2, 5, 4, 2, 3, 4, 1, 1, 51 ]

12

true

Domain

Vacuolar protein 14, C-terminal Fig4-binding domain

VAC14_Fig4p-bd

3

IPR021842

21,842

Protein of unknown function DUF3435

DUF3435

Family

4,269

false

This family of proteins are functionally uncharacterised. This protein is found in eukaryotes. Proteins in this family are typically between 435 to 791 amino acids in length. This family is related to suggesting it may be an integrase enzyme.

[]

0

[ "PFAM" ]

[ "PF11917" ]

[ "DUF3435" ]

[ 4269 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Opisthokonta" ]

[ 4269 ]

1

[]

0

true

Family

Protein of unknown function DUF3435

DUF3435

9

IPR021844

21,844

Integrating conjugative element protein, PFL4704

Integr_conj_element_PFL4704

Family

1,952

false

Members of this protein family are found occasionally on plasmids such as the Pseudomonas putida TOL plasmid pWWO_p085. Usually, however, they are found on the bacterial main chromosome in a region flanked by markers of conjugative transfer and/or transposition.

[]

0

[ "PFAM", "NCBIFAM" ]

[ "PF11920", "TIGR03749" ]

[ "DUF3438", "conj_TIGR03749" ]

[ 1952, 1826 ]

2

[ "GP" ]

[ "GenProp0855" ]

[ "GP:GenProp0855" ]

1

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 1933, 3, 16 ]

3

[]

0

true

Family

Integrating conjugative element protein, PFL4704

Integr_conj_element_PFL4704

4

IPR021845

21,845

Protein of unknown function DUF3440

DUF3440

Family

2,342

false

This presumed domain is functionally uncharacterised. This domain is found in bacteria. This domain is typically between 53 to 190 amino acids in length. This domain is found associated with . This domain has a conserved KND sequence motif.

[]

0

[ "PFAM" ]

[ "PF11922" ]

[ "DUF3440" ]

[ 2342 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Caudoviricetes", "metagenomes" ]

[ 2, 2279, 46, 15 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Protein of unknown function DUF3440

DUF3440

5

IPR021846

21,846

NFACT protein, C-terminal

NFACT-C

Domain

4,274

false

This is the C-terminal domain of the NFACT (NEMF, FbpA, Caliban, and Tae2) proteins involved in the ribosomal quality control pathway. This context is conserved in archaea and eukaryotes, but NFACT proteins in bacteria lack the NFACT-C domain [ ].

[]

0

[ "PFAM" ]

[ "PF11923" ]

[ "NFACT-C" ]

[ 4274 ]

1

[]

0

[ "8aaf", "8agt", "8agu", "8agv", "8agw", "8agx", "8agz", "9gy4", "9ofv" ]

9

[ "PUB00091027" ]

[ "24646681" ]

[ "A highly conserved family of domains related to the DNA-glycosylase fold helps predict multiple novel pathways for RNA modifications." ]

[ 2014 ]

1

[]

0

null

[ "Bodo saltans virus", "Eukaryota", "seawater metagenome" ]

[ 1, 4272, 1 ]

3

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 5, 1, 2, 2, 2, 1, 1, 5, 5, 1, 1, 7 ]

12

true

Domain

NFACT protein, C-terminal

NFACT-C

5

IPR021847

21,847

Protein of unknown function DUF3443

DUF3443

Family

984

false

This family of proteins are functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 400 to 434 amino acids in length. This protein has two conserved sequence motifs: NPV and DNNG.

[]

0

[ "PFAM" ]

[ "PF11925" ]

[ "DUF3443" ]

[ 984 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "ecological metagenomes" ]

[ 958, 2, 24 ]

3

[]

0

true

Family

Protein of unknown function DUF3443

DUF3443

1

IPR021848

21,848

Haem-dependent oxidative N-demethylase, alpha subunit-like

HODM_asu-like

Family

7,314

false

This entry represents a family of proteins predominantly found in fungi and bacteria, including the alpha subunit of an haem-dependent oxidative N-demethylase (HODM) from Pseudomonas mendocina (Pmen_3455, ). This protein, catalytically active, is responsible for haem, oxygen and NADPH-dependent dimethylamine (DMA) bind...

[]

0

[ "PFAM" ]

[ "PF11927" ]

[ "HODM_asu-like" ]

[ 7314 ]

1

[]

0

[ "5lte", "5lth", "5lti" ]

3

[ "PUB00100877", "PUB00100878" ]

[ "27851736", "22622145" ]

[ "An oxidative N-demethylase reveals PAS transition from ubiquitous sensor to enzyme.", "Structural basis for oxygen sensing and signal transduction of the heme-based sensor protein Aer2 from Pseudomonas aeruginosa." ]

[ 2016, 2012 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 2454, 4792, 68 ]

3

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)" ]

[ 3 ]

1

true

Family

Haem-dependent oxidative N-demethylase, alpha subunit-like

HODM_asu-like

1

IPR021849

21,849

Early growth response, N-terminal

EGR_N

Domain

5,821

false

Proteins containing this domain include early growth response protein 1/2/3 (EGR1/2/3). EGR1 is a transcriptional regulator that binds specifically to 9-bp target sequences containing two CpG sites that can potentially be methylated at four cytosine bases [ ]. EGR2, also known as Krox20, is an E3 ligase that sumoylates...

[]

0

[ "PFAM" ]

[ "PF11928" ]

[ "DUF3446" ]

[ 5821 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-DRE-9031628", "R-HSA-381340", "R-HSA-5617472", "R-HSA-8943724", "R-HSA-9031628", "R-HSA-909733", "R-HSA-9619665", "R-MMU-9031628", "R-RNO-9031628", "R-SSC-9031628" ]

[ "REACTOME:R-DRE-9031628", "REACTOME:R-HSA-381340", "REACTOME:R-HSA-5617472", "REACTOME:R-HSA-8943724", "REACTOME:R-HSA-9031628", "REACTOME:R-HSA-909733", "REACTOME:R-HSA-9619665", "REACTOME:R-MMU-9031628", "REACTOME:R-RNO-9031628", "REACTOME:R-SSC-9031628" ]

10

[ "9bv3" ]

1

[ "PUB00086407", "PUB00086408" ]

[ "21836637", "25999311" ]

[ "The transcription factor Krox20 is an E3 ligase that sumoylates its Nab coregulators.", "Structural impact of complete CpG methylation within target DNA on specific complex formation of the inducible transcription factor Egr-1." ]

[ 2011, 2015 ]

2

[]

0

null

[ "Gnathostomata", "Kangiella spongicola" ]

[ 5820, 1 ]

2

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 10, 11, 15, 17 ]

4

true

Domain

Early growth response, N-terminal

EGR_N

5