interpro_id string | interpro_numeric_id int64 | name string | short_name string | entry_type string | protein_count int64 | is_llm bool | is_llm_reviewed bool | abstract string | go_ids list | go_terms list | go_categories list | go_count int64 | member_databases list | member_accessions list | member_names list | member_protein_counts list | member_count int64 | external_databases list | external_accessions list | external_xrefs list | external_xref_count int64 | pdb_ids list | structure_count int64 | publication_ids list | pubmed_ids list | publication_titles list | publication_years list | publication_count int64 | parent_ids list | child_ids list | parent_count int64 | child_count int64 | tree_depth float64 | taxonomy_names list | taxonomy_protein_counts list | taxonomy_count int64 | key_species_names list | key_species_protein_counts list | key_species_count int64 | in_entry_list bool | entry_list_type string | entry_list_name string | names_dat_name string | short_names_dat_name string | split_bucket int64 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
IPR022084 | 22,084 | Transcription factor Elf, N-terminal | TF_Elf_N | Domain | 3,380 | false | false | Elf (E74-like-factor) is a subfamily of the ETS transcription factor family [ ]. Elf-1 is an immune cell specific transcription factor. It is found in T cells, B cells, megakaryocytes,and mast cells and is involved in the control of transcription for various immune proteins [ ]. Included in the Elf subfamily are also E... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12310"
] | [
"Elf-1_N"
] | [
3380
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-8939247",
"R-HSA-8939245",
"R-HSA-8939247",
"R-MMU-8939245",
"R-MMU-8939247"
] | [
"REACTOME:R-BTA-8939247",
"REACTOME:R-HSA-8939245",
"REACTOME:R-HSA-8939247",
"REACTOME:R-MMU-8939245",
"REACTOME:R-MMU-8939247"
] | 5 | [] | 0 | [
"PUB00057214",
"PUB00057216",
"PUB00057217",
"PUB00057218"
] | [
"11210123",
"8756667",
"19412182",
"11715049"
] | [
"Splice isoforms of transcription factor Elf-1 affecting its regulatory function in transcription-molecular cloning of rat Elf-1.",
"Characterization of NERF, a novel transcription factor related to the Ets factor ELF-1.",
"Transcription factor ELF4 controls the proliferation and homing of CD8+ T cells via the ... | [
2000,
1996,
2009,
2001
] | 4 | [] | [] | 0 | 0 | null | [
"Chordata"
] | [
3380
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
11,
11,
18,
18
] | 4 | true | Domain | Transcription factor Elf, N-terminal | Transcription factor Elf, N-terminal | TF_Elf_N | 1 |
IPR022085 | 22,085 | Oxopyrrolidines biosynthesis cluster protein G | OpdG | Family | 4,610 | false | false | This family includes oxopyrrolidines biosynthesis cluster protein G (OpdG) which is part of the gene cluster that mediates the biosynthesis of oxopyrrolidines, polyketide-amino acid hybrid compounds with feature structures of tetramic acid [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12311"
] | [
"DUF3632"
] | [
4610
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00101884"
] | [
"36005526"
] | [
"Identification of PKS-NRPS Hybrid Metabolites in Marine-Derived <i>Penicillium oxalicum</i>."
] | [
2022
] | 1 | [] | [] | 0 | 0 | null | [
"Actinomycetes",
"Eukaryota"
] | [
18,
4592
] | 2 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)"
] | [
3
] | 1 | true | Family | Oxopyrrolidines biosynthesis cluster protein G | Oxopyrrolidines biosynthesis cluster protein G | OpdG | 3 |
IPR022086 | 22,086 | Inner membrane complex protein | IMCp | Family | 1,506 | false | false | This domain is found in bacteria and eukaryotes. This domain is about 120 amino acids in length. This family is the inner membrane complex of parasitic organisms. This is a cytoskeletal structure associated with the pellicle of these parasites. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12314"
] | [
"IMCp"
] | [
1506
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"viral metagenome"
] | [
18,
1487,
1
] | 3 | [] | [] | 0 | true | Family | Inner membrane complex protein | Inner membrane complex protein | IMCp | 1 |
IPR022087 | 22,087 | Protein DA1-like domain | DA1-like_dom | Domain | 3,877 | false | false | Proteins containing this domain include protein DA1 and its homologues. In Arabidopsis thaliana, DA1 is a ubiquitin-activated endopeptidase that limits final seed and organ size by restricting the period of cell proliferation [ ]. DA1 is activated by the RING E3 ligases Big Brother and DA2, both of which are then inact... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12315"
] | [
"DA1-like"
] | [
3877
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00066861",
"PUB00085156"
] | [
"18483219",
"28167503"
] | [
"Control of final seed and organ size by the DA1 gene family in Arabidopsis thaliana.",
"Ubiquitylation activates a peptidase that promotes cleavage and destabilization of its activating E3 ligases and diverse growth regulatory proteins to limit cell proliferation in Arabidopsis."
] | [
2008,
2017
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
83,
3788,
6
] | 3 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
44,
16,
51
] | 3 | true | Domain | Protein DA1-like domain | Protein DA1-like domain | DA1-like_dom | 4 |
IPR022089 | 22,089 | Tryptophan/threonine-rich plasmodium antigen, C-terminal | Plasmodium-antigen_C | Domain | 1,147 | false | false | This domain is found in the C-terminal region of the surface antigen of malarial Plasmodium species. This antigen is currently being targeted for use as part of a subunit vaccine against Plasmodium falciparum, the main species involved in causing human malaria [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12319"
] | [
"TryThrA_C"
] | [
1147
] | 1 | [] | [] | [] | 0 | [
"8arl"
] | 1 | [
"PUB00057213"
] | [
"15383306"
] | [
"Characterisation of a tryptophan-rich Plasmodium falciparum antigen associated with merozoites."
] | [
2004
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Oxyplasma meridianum"
] | [
3,
1143,
1
] | 3 | [] | [] | 0 | true | Domain | Tryptophan/threonine-rich plasmodium antigen, C-terminal | Tryptophan/threonine-rich plasmodium antigen, C-terminal | Plasmodium-antigen_C | 4 |
IPR022090 | 22,090 | Protein of unknown function DUF3634 | DUF3634 | Family | 526 | false | false | This family of proteins is found in bacteria. Proteins in this family are typically between 103 and 114 amino acids in length. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12321"
] | [
"DUF3634"
] | [
526
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"unclassified sequences"
] | [
524,
2
] | 2 | [] | [] | 0 | true | Family | Protein of unknown function DUF3634 | Protein of unknown function DUF3634 | DUF3634 | 3 |
IPR022091 | 22,091 | TATA element modulatory factor 1, TATA binding | TMF_TATA-bd | Domain | 4,082 | false | false | This is the C-terminal conserved coiled coil region of a family of TATA element modulatory factor 1 proteins conserved in eukaryotes [ ]. The proteins bind to the TATA element of some RNA polymerase II promoters and repress their activity. by competing with the binding of TATA binding protein. TMF1_TATA_bd is the most ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12325"
] | [
"TMF_TATA_bd"
] | [
4082
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-6811440",
"R-MMU-6811440",
"R-SCE-6811440"
] | [
"REACTOME:R-HSA-6811440",
"REACTOME:R-MMU-6811440",
"REACTOME:R-SCE-6811440"
] | 3 | [] | 0 | [
"PUB00053487",
"PUB00053488",
"PUB00053489"
] | [
"1409643",
"15128430",
"18182439"
] | [
"Cloning and chromosomal mapping of a human immunodeficiency virus 1 \"TATA\" element modulatory factor.",
"TMF is a golgin that binds Rab6 and influences Golgi morphology.",
"Localization and domain characterization of Arabidopsis golgin candidates."
] | [
1992,
2004,
2007
] | 3 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota"
] | [
4,
4078
] | 2 | [
"Arabidopsis thaliana",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"... | [
8,
2,
1,
3,
1,
1,
4,
2,
1,
1,
20
] | 11 | true | Domain | TATA element modulatory factor 1, TATA binding | TATA element modulatory factor 1, TATA binding | TMF_TATA-bd | 5 |
IPR022092 | 22,092 | TATA element modulatory factor 1 DNA binding | TMF_DNA-bd | Family | 3,921 | false | false | This is the middle region of a family of TATA element modulatory factor 1 (TMF1) proteins conserved in eukaryotes that contains at its N-terminal section a number of leucine zippers that could potentially form coiled coil structures. The whole proteins bind to the TATA element of some RNA polymerase II promoters and re... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12329"
] | [
"TMF_DNA_bd"
] | [
3921
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-6811440",
"R-MMU-6811440",
"R-SCE-6811440"
] | [
"REACTOME:R-HSA-6811440",
"REACTOME:R-MMU-6811440",
"REACTOME:R-SCE-6811440"
] | 3 | [] | 0 | [
"PUB00053488",
"PUB00053489"
] | [
"15128430",
"18182439"
] | [
"TMF is a golgin that binds Rab6 and influences Golgi morphology.",
"Localization and domain characterization of Arabidopsis golgin candidates."
] | [
2004,
2007
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
3921
] | 1 | [
"Arabidopsis thaliana",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"... | [
7,
2,
2,
4,
2,
1,
6,
5,
1,
1,
33
] | 11 | true | Family | TATA element modulatory factor 1 DNA binding | TATA element modulatory factor 1 DNA binding | TMF_DNA-bd | 1 |
IPR022093 | 22,093 | Rad26-like, helical repeats | Rad26-like_helical | Domain | 1,044 | false | false | This domain is found in fungal proteins, including Rad26 ( ) from Myceliophthora thermophila, a functional subunit of the Rad3-Rad26 complex that is responsible for bringing the kinase to sites of DNA damage. The central region of Rad26 is formed by five helical repeats forming an α-solenoid arrangement [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12331"
] | [
"Rad26-like_helical_rpts"
] | [
1044
] | 1 | [] | [] | [] | 0 | [
"5loi"
] | 1 | [
"PUB00100970"
] | [
"28314775"
] | [
"Insights into Rad3 kinase recruitment from the crystal structure of the DNA damage checkpoint protein Rad26."
] | [
2017
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1044
] | 1 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)"
] | [
1
] | 1 | true | Domain | Rad26-like, helical repeats | Rad26-like, helical repeats | Rad26-like_helical | 2 |
IPR022095 | 22,095 | Outer membrane protein B, passenger domain, Rickettsia | OmpB_passenger_Rickettsia | Domain | 1,049 | false | false | This domain is found in the outer membrane protein B of Rickettsia (rOmpB), a surface-exposed major structural protein which is involved in adhesion and invasion of host cells, playing a role as a rickettsial virulence factor and immunogen during infection, as it serves as a protective envelope [ , , , ]. These protein... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12334"
] | [
"rOmpB_passenger"
] | [
1049
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00151447",
"PUB00151448",
"PUB00151449",
"PUB00151450"
] | [
"19134120",
"16574381",
"21444665",
"27474738"
] | [
"Rickettsial outer-membrane protein B (rOmpB) mediates bacterial invasion through Ku70 in an actin, c-Cbl, clathrin and caveolin 2-dependent manner.",
"Identification of two putative rickettsial adhesins by proteomic analysis.",
"Molecular basis of immunity to rickettsial infection conferred through outer membr... | [
2009,
2006,
2011,
2016
] | 4 | [] | [] | 0 | 0 | null | [
"Didymodactylos carnosus",
"Rickettsieae"
] | [
1,
1048
] | 2 | [] | [] | 0 | true | Domain | Outer membrane protein B, passenger domain, Rickettsia | Outer membrane protein B, passenger domain, Rickettsia | OmpB_passenger_Rickettsia | 4 |
IPR022096 | 22,096 | SBF1/SBF2 domain | SBF1/SBF2 | Domain | 5,601 | false | false | This domain is found in eukaryotes, and is approximately 220 amino acids in length. It is found in association with , . It is found is the middle region of SBF1 and SBF2, members of the myotubularin family. Myotubularin-related proteins have been suggested to work in phosphoinositide-mediated signalling events that may... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12335"
] | [
"SBF2"
] | [
5601
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-CEL-1483248",
"R-CEL-8876198",
"R-HSA-1483248",
"R-HSA-1660499",
"R-HSA-8876198",
"R-MMU-1483248",
"R-MMU-8876198"
] | [
"REACTOME:R-CEL-1483248",
"REACTOME:R-CEL-8876198",
"REACTOME:R-HSA-1483248",
"REACTOME:R-HSA-1660499",
"REACTOME:R-HSA-8876198",
"REACTOME:R-MMU-1483248",
"REACTOME:R-MMU-8876198"
] | 7 | [] | 0 | [
"PUB00073222",
"PUB00073236",
"PUB00101186"
] | [
"12554688",
"20937701",
"25648148"
] | [
"Mutation of the SBF2 gene, encoding a novel member of the myotubularin family, in Charcot-Marie-Tooth neuropathy type 4B2/11p15.",
"Family-wide characterization of the DENN domain Rab GDP-GTP exchange factors.",
"Starvation-induced MTMR13 and RAB21 activity regulates VAMP8 to promote autophagosome-lysosome fus... | [
2003,
2010,
2015
] | 3 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
5601
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
14,
7,
33,
9,
16
] | 6 | true | Domain | SBF1/SBF2 domain | SBF1/SBF2 domain | SBF1/SBF2 | 9 |
IPR022097 | 22,097 | Transcription factor SOX | SOX_fam | Family | 4,454 | false | false | This entry represents a group of eukaryotic transcription factors known as SOX [ ]. Proteins in this family usually contain the high mobility group box domain ( ). They are regulators of cell fate decisions during development [ ]. | [
"GO:0006355"
] | [
"regulation of DNA-templated transcription"
] | [
"biological_process"
] | 1 | [
"PFAM"
] | [
"PF12336"
] | [
"SOXp"
] | [
4454
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-DRE-3769402",
"R-GGA-3769402",
"R-HSA-2892245",
"R-HSA-2892247",
"R-HSA-3769402",
"R-HSA-452723",
"R-HSA-6785807",
"R-HSA-8986944",
"R-HSA-9754189",
"R-HSA-9823739",
"R-HSA-9832991",
"R-HSA-9834899",
"R-HSA-9856649",
"R-HSA-9926550",
"R-MMU-3769402",
"R-XTR-3769402"
] | [
"REACTOME:R-DRE-3769402",
"REACTOME:R-GGA-3769402",
"REACTOME:R-HSA-2892245",
"REACTOME:R-HSA-2892247",
"REACTOME:R-HSA-3769402",
"REACTOME:R-HSA-452723",
"REACTOME:R-HSA-6785807",
"REACTOME:R-HSA-8986944",
"REACTOME:R-HSA-9754189",
"REACTOME:R-HSA-9823739",
"REACTOME:R-HSA-9832991",
"REACTOME... | 16 | [
"6wx7",
"6wx8",
"6wx9"
] | 3 | [
"PUB00075412",
"PUB00075413"
] | [
"23290134",
"12194848"
] | [
"The sox family of transcription factors: versatile regulators of stem and progenitor cell fate.",
"Twenty pairs of sox: extent, homology, and nomenclature of the mouse and human sox transcription factor gene families."
] | [
2013,
2002
] | 2 | [] | [] | 0 | 0 | null | [
"Eumetazoa"
] | [
4454
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
11,
3,
12,
18,
10
] | 5 | true | Family | Transcription factor SOX | Transcription factor SOX | SOX_fam | 2 |
IPR022098 | 22,098 | Protein of unknown function DUF3637 | DUF3637 | Family | 156 | false | false | This domain family is found in viruses, and is approximately 70 amino acids in length. The family is found in association with , . | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12337"
] | [
"DUF3637"
] | [
156
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Teschovirus"
] | [
156
] | 1 | [] | [] | 0 | true | Family | Protein of unknown function DUF3637 | Protein of unknown function DUF3637 | DUF3637 | 7 |
IPR022100 | 22,100 | WDHD1/CFT4, second beta-propeller | WDHD1/CFT4_beta-prop_2nd | Domain | 4,690 | false | false | This entry represents the second β-propeller domain found in the middle region of WDHD1 (also known as AND-1) from human and at the C-terminal of its orthologues from yeast, CFT4 and minichromosome loss protein 1 (Mcl1) [[28381552]]. This domain, together with the helical bundle ( ) forms the SepB domain, which mediate... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12341"
] | [
"Mcl1_mid"
] | [
4690
] | 1 | [] | [] | [] | 0 | [
"4c8h",
"4c8s",
"4c93",
"4c95",
"5gvb",
"5hog",
"5hoi",
"5nxq",
"5ogs",
"6ptj",
"6ptn",
"6pto",
"6skl",
"6xty",
"7pfo",
"7plo",
"7pmk",
"7pmn",
"8b9a",
"8b9b",
"8b9d",
"8kg6",
"8kg8",
"8kg9",
"8w7m",
"8w7s",
"8xgc"
] | 27 | [
"PUB00151993",
"PUB00151996",
"PUB00154917"
] | [
"28381552",
"35585232",
"34694004"
] | [
"The structure and polymerase-recognition mechanism of the crucial adaptor protein AND-1 in the human replisome.",
"Fast and efficient DNA replication with purified human proteins.",
"Structure of a human replisome shows the organisation and interactions of a DNA replication machine."
] | [
2017,
2022,
2021
] | 3 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
4690
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
5,
1,
3,
5,
5,
4,
1,
2,
4,
1,
1,
8
] | 12 | true | Domain | WDHD1/CFT4, second beta-propeller | WDHD1/CFT4, second beta-propeller | WDHD1/CFT4_beta-prop_2nd | 8 |
IPR022101 | 22,101 | GB virus C, polyprotein N-terminal | GB_virus-C_polyprotein_N | Domain | 32 | false | false | This entry defines the N-terminal domain of the polyprotein of GB virus C; its function is not known. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12342"
] | [
"DUF3640"
] | [
32
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Pegivirus"
] | [
32
] | 1 | [] | [] | 0 | true | Domain | GB virus C, polyprotein N-terminal | GB virus C, polyprotein N-terminal | GB_virus-C_polyprotein_N | 6 |
IPR022102 | 22,102 | Holliday junction regulator protein family C-terminal | HJURP_C | Domain | 7,542 | false | false | Although this family is conserved in the Holliday junction regulator, HJURP, proteins in higher eukaryotes, alongside an Scm3, , family, its exact function is not known. The C-terminal region of Scm3 proteins has been evolving rapidly, and this short repeat at the C-terminal end can be present in up to two copies in th... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12347"
] | [
"HJURP_C"
] | [
7542
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-525793",
"R-DME-525793",
"R-HSA-198753",
"R-HSA-2151201",
"R-HSA-525793",
"R-HSA-606279",
"R-HSA-69273",
"R-HSA-9022707",
"R-HSA-9031628",
"R-HSA-9707616",
"R-HSA-9733709",
"R-HSA-9931509",
"R-MMU-525793",
"R-MMU-606279",
"R-MMU-69273",
"R-RNO-525793"
] | [
"REACTOME:R-BTA-525793",
"REACTOME:R-DME-525793",
"REACTOME:R-HSA-198753",
"REACTOME:R-HSA-2151201",
"REACTOME:R-HSA-525793",
"REACTOME:R-HSA-606279",
"REACTOME:R-HSA-69273",
"REACTOME:R-HSA-9022707",
"REACTOME:R-HSA-9031628",
"REACTOME:R-HSA-9707616",
"REACTOME:R-HSA-9733709",
"REACTOME:R-HSA... | 16 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eumetazoa",
"Methanochimaera problematica"
] | [
7541,
1
] | 2 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
76,
8,
30,
28,
22
] | 5 | true | Domain | Holliday junction regulator protein family C-terminal | Holliday junction regulator protein family C-terminal | HJURP_C | 7 |
IPR022103 | 22,103 | Baculoviral IAP repeat-containing protein 6 | BIRC6 | Family | 2,086 | false | false | Baculoviral IAP repeat-containing protein 6 (BIRC6, also known as BRUCE) is an anti-apoptotic protein which can regulate cell death by controlling caspases and by acting as an E3 ubiquitin-protein ligase [ ]. It has an unusual ubiquitin conjugation system in that it could combine in a single polypeptide, ubiquitin conj... | [
"GO:0004842",
"GO:0006915",
"GO:0032465"
] | [
"ubiquitin-protein transferase activity",
"apoptotic process",
"regulation of cytokinesis"
] | [
"molecular_function",
"biological_process",
"biological_process"
] | 3 | [
"PFAM"
] | [
"PF12356"
] | [
"BIRC6"
] | [
2086
] | 1 | [
"REACTOME",
"REACTOME"
] | [
"R-HSA-9700645",
"R-HSA-9725370"
] | [
"REACTOME:R-HSA-9700645",
"REACTOME:R-HSA-9725370"
] | 2 | [
"8atm",
"8ato",
"8atu",
"8atx",
"8auk",
"8auw",
"8e2d",
"8e2e",
"8e2f",
"8e2g",
"8e2h",
"8e2i",
"8e2k",
"8ivq"
] | 14 | [
"PUB00047485",
"PUB00069151",
"PUB00069152"
] | [
"14765125",
"15200957",
"18329369"
] | [
"Nrdp1-mediated degradation of the gigantic IAP, BRUCE, is a novel pathway for triggering apoptosis.",
"Dual role of BRUCE as an antiapoptotic IAP and a chimeric E2/E3 ubiquitin ligase.",
"Final stages of cytokinesis and midbody ring formation are controlled by BRUCE."
] | [
2004,
2004,
2008
] | 3 | [] | [] | 0 | 0 | null | [
"Metazoa"
] | [
2086
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
23,
5,
5,
5,
4
] | 5 | true | Family | Baculoviral IAP repeat-containing protein 6 | Baculoviral IAP repeat-containing protein 6 | BIRC6 | 6 |
IPR022104 | 22,104 | Domain of unknown function DUF3644 | DUF3644 | Domain | 927 | false | false | This entry represents a HEPN-like domain found in bacterial proteins. The AlphaFold structures show this group of proteins is a part of the Nucleotidyltransferase substrate binding domain superfamily. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12358"
] | [
"DUF3644"
] | [
927
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Caudoviricetes",
"Methanobacteriota",
"unclassified sequences"
] | [
897,
6,
11,
13
] | 4 | [] | [] | 0 | true | Domain | Domain of unknown function DUF3644 | Domain of unknown function DUF3644 | DUF3644 | 1 |
IPR022105 | 22,105 | Domain of unknown function DUF3645 | DUF3645 | Domain | 3,740 | false | false | This domain family is found in eukaryotes, and is approximately 40 amino acids in length. There is a conserved HPD sequence motif. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12359"
] | [
"DUF3645"
] | [
3740
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Candidatus Criblamydia sequanensis CRIB-18",
"Eukaryota",
"Klosneuvirinae"
] | [
1,
3737,
2
] | 3 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)"
] | [
1
] | 1 | true | Domain | Domain of unknown function DUF3645 | Domain of unknown function DUF3645 | DUF3645 | 5 |
IPR022106 | 22,106 | Paired box protein 7, C-terminal | Pax7_C | Domain | 2,628 | false | false | This domain is found in the C-terminal region of Pax7, which is a transcription factor playing a role in myogenesis through regulation of muscle precursor cells proliferation [ ]. Proteins containing this domain also include Pax3. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12360"
] | [
"Pax7"
] | [
2628
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-3214847",
"R-HSA-9834899",
"R-HSA-9856649",
"R-MMU-3214847"
] | [
"REACTOME:R-HSA-3214847",
"REACTOME:R-HSA-9834899",
"REACTOME:R-HSA-9856649",
"REACTOME:R-MMU-3214847"
] | 4 | [] | 0 | [
"PUB00077472"
] | [
"22862948"
] | [
"Pax3/7BP is a Pax7- and Pax3-binding protein that regulates the proliferation of muscle precursor cells by an epigenetic mechanism."
] | [
2012
] | 1 | [] | [] | 0 | 0 | null | [
"Vertebrata"
] | [
2628
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
11,
7,
9,
8
] | 4 | true | Domain | Paired box protein 7, C-terminal | Paired box protein 7, C-terminal | Pax7_C | 9 |
IPR022107 | 22,107 | DNA polymerase III, subunit gamma/ tau, C-terminal | DNA_pol_III_gamma/tau_C | Domain | 2,980 | false | false | This domain is found in bacteria, and is approximately 120 amino acids in length. It is found in association with . The proteins in this family are frequently annotated as the gamma and tau subunits of DNA polymerase III, however there is little accompanying literature to back this up. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12362"
] | [
"DUF3646"
] | [
2980
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
2933,
12,
35
] | 3 | [] | [] | 0 | true | Domain | DNA polymerase III, subunit gamma/ tau, C-terminal | DNA polymerase III, subunit gamma/ tau, C-terminal | DNA_pol_III_gamma/tau_C | 1 |
IPR022108 | 22,108 | Protein of unknown function DUF3648 | DUF3648 | Family | 202 | false | false | This family of proteins is found in eukaryotes and viruses. Proteins in this family are typically between 53 and 3115 amino acids in length. There are two completely conserved residues (A and F) that may be functionally important. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12364"
] | [
"DUF3648"
] | [
202
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Citrus tristeza virus",
"Eukaryota",
"Pseudomonadati"
] | [
156,
44,
2
] | 3 | [] | [] | 0 | true | Family | Protein of unknown function DUF3648 | Protein of unknown function DUF3648 | DUF3648 | 5 |
IPR022109 | 22,109 | Protein of unknown function DUF3649 | DUF3649 | Family | 1,304 | false | false | This domain family is found in bacteria and eukaryotes, and is approximately 30 amino acids in length. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12365"
] | [
"DUF3649"
] | [
1304
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Fungi",
"metagenomes"
] | [
1288,
2,
14
] | 3 | [] | [] | 0 | true | Family | Protein of unknown function DUF3649 | Protein of unknown function DUF3649 | DUF3649 | 6 |
IPR022110 | 22,110 | CASC1, C-terminal | CASC1_C | Domain | 1,129 | false | false | This domain can be found at the C terminus of CASC1. The CAncer Susceptibility Candidate 1 (CASC1) gene is expressed in lung tissues, and is a strong candidate for the pulmonary adenoma susceptibility 1 (Pas1) locus, the major determinant of strain variation in lung tumour susceptibility [ ]. There appears to be a stro... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12366"
] | [
"Casc1_C"
] | [
1129
] | 1 | [] | [] | [] | 0 | [
"8j07"
] | 1 | [
"PUB00054091",
"PUB00054092"
] | [
"16410263",
"14583591"
] | [
"A V141L polymorphism of the human LRMP gene is associated with survival of lung cancer patients.",
"Positional cloning of the major quantitative trait locus underlying lung tumor susceptibility in mice."
] | [
2006,
2003
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1129
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens"
] | [
4,
8,
6
] | 3 | true | Domain | CASC1, C-terminal | CASC1, C-terminal | CASC1_C | 1 |
IPR022113 | 22,113 | Transmembrane protein 131-like, N-terminal | TMEM131L_N | Domain | 3,779 | false | false | This domain can be found in bacterial, plant and other metazoa transmembrane proteins TMEM131L and TMEM131. Many of the members are multi-pass transmembrane proteins. This domain represents the N-terminal region [ ]. Transmembrane protein 131-like (TMEM131L) was identified as a negative regulator of thymocyte prolifera... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12371"
] | [
"TMEM131_like_N"
] | [
3779
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00090250",
"PUB00155677"
] | [
"23690469",
"32095531"
] | [
"Identification of TMEM131L as a novel regulator of thymocyte proliferation in humans.",
"Broadly conserved roles of TMEM131 family proteins in intracellular collagen assembly and secretory cargo trafficking."
] | [
2013,
2020
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Henunavirus"
] | [
13,
3764,
2
] | 3 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
1,
7,
1,
5,
5,
4,
11,
5
] | 8 | true | Domain | Transmembrane protein 131-like, N-terminal | Transmembrane protein 131-like, N-terminal | TMEM131L_N | 3 |
IPR022114 | 22,114 | Doublesex- and mab-3-related transcription factor 1-like | DMRT1-like | Family | 1,347 | false | false | This family is found in eukaryotes, and is typically between 61 and 73 amino acids in length. They are suggested to be transcription factor proteins. In Xenopus laevis, doublesex- and mab-3-related transcription factor 1a (dmrt1-a) is a transcription factor that plays a key role in male sex determination and differenti... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12374"
] | [
"Dmrt1"
] | [
1347
] | 1 | [
"REACTOME"
] | [
"R-HSA-9690406"
] | [
"REACTOME:R-HSA-9690406"
] | 1 | [] | 0 | [
"PUB00060804",
"PUB00060805",
"PUB00060806"
] | [
"17118014",
"20573695",
"18268317"
] | [
"Expression and promoter analysis of Xenopus DMRT1 and functional characterization of the transactivation property of its protein.",
"Opposite roles of DMRT1 and its W-linked paralogue, DM-W, in sexual dimorphism of Xenopus laevis: implications of a ZZ/ZW-type sex-determining system.",
"A W-linked DM-domain gen... | [
2006,
2010,
2008
] | 3 | [
"IPR026607"
] | [] | 1 | 0 | 1 | [
"Gnathostomata",
"Pseudomonas"
] | [
1344,
3
] | 2 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
2,
2,
2
] | 4 | true | Family | Doublesex- and mab-3-related transcription factor 1-like | Doublesex- and mab-3-related transcription factor 1-like | DMRT1-like | 2 |
IPR022115 | 22,115 | Protein of unknown function DUF3654 | DUF3654 | Family | 112 | false | false | This family of proteins is found in eukaryotes. Proteins in this family are typically between 193 and 612 amino acids in length. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12376"
] | [
"DUF3654"
] | [
112
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Apansporoblastina"
] | [
112
] | 1 | [] | [] | 0 | true | Family | Protein of unknown function DUF3654 | Protein of unknown function DUF3654 | DUF3654 | 5 |
IPR022116 | 22,116 | Adhesin P1, N-terminal | P1_N | Domain | 324 | false | false | This domain is found at the N-terminal of adhesins and hypothetical adhesin-like proteins from Mycoplasma pneumoniae and Mycoplasma genitalium, including adhesin P1 which was first identified as the major determinant for cytoadherence and gliding motility in M. pneumoniae [ , ]. P1 forms a transmembrane adhesion comple... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12378"
] | [
"P1_N"
] | [
324
] | 1 | [] | [] | [] | 0 | [
"6rc9",
"6rut",
"6s3u",
"6yrk",
"7bwm",
"8pbx",
"8pby",
"8pbz",
"8pc0",
"8pc1",
"8ror"
] | 11 | [
"PUB00098588",
"PUB00098589"
] | [
"33057023",
"32513917"
] | [
"Immunodominant proteins P1 and P40/P90 from human pathogen Mycoplasma pneumoniae.",
"Structure and mechanism of the Nap adhesion complex from the human pathogen Mycoplasma genitalium."
] | [
2020,
2020
] | 2 | [] | [] | 0 | 0 | null | [
"Mycoplasmatota"
] | [
324
] | 1 | [] | [] | 0 | true | Domain | Adhesin P1, N-terminal | Adhesin P1, N-terminal | P1_N | 9 |
IPR022117 | 22,117 | Severe acute respiratory syndrome coronavirus 3b protein | SARS_3b | Family | 89 | false | false | This family contains the SARS coronavirus 3b protein which is predominantly localized in the nucleolus, and induces G0/G1 arrest and apoptosis in transfected cells [ , ]. SARS-CoV mRNA 3 encodes the distinct proteins ORF3a and ORF3b proteins, which are translated in different reading frames. SARS-CoV accessory protein ... | [] | [] | [] | 0 | [
"PFAM",
"CDD"
] | [
"PF12383",
"cd21649"
] | [
"SARS_3b",
"SARS-CoV_ORF3b"
] | [
89,
47
] | 2 | [
"REACTOME"
] | [
"R-HSA-9692916"
] | [
"REACTOME:R-HSA-9692916"
] | 1 | [] | 0 | [
"PUB00094538",
"PUB00094539",
"PUB00095864",
"PUB00095865",
"PUB00095866"
] | [
"16682811",
"16107218",
"16046244",
"22012463",
"17108024"
] | [
"Mitochondrial location of severe acute respiratory syndrome coronavirus 3b protein.",
"G0/G1 arrest and apoptosis induced by SARS-CoV 3b protein in transfected cells.",
"Nucleolar localization of non-structural protein 3b, a protein specifically encoded by the severe acute respiratory syndrome coronavirus.",
... | [
2006,
2005,
2005,
2012,
2007
] | 5 | [] | [] | 0 | 0 | null | [
"Orthocoronavirinae"
] | [
89
] | 1 | [] | [] | 0 | true | Family | Severe acute respiratory syndrome coronavirus 3b protein | Severe acute respiratory syndrome coronavirus 3b protein | SARS_3b | 6 |
IPR022118 | 22,118 | Peptidase C70, AvrRpt2 | Peptidase_C70_AvrRpt2 | Family | 1,397 | false | false | This is a family of bacterial cysteine proteases. Papain-like cysteine proteases play a crucial role in plant-pathogen/pest interactions. On entering the host they act on non-self substrates, thereby manipulating the host to evade proteolysis [ ]. AvrRpt2 from Pseudomonas syringae pv tomato DC3000 triggers resistance t... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12385"
] | [
"Peptidase_C70"
] | [
1397
] | 1 | [] | [] | [] | 0 | [
"6hqz"
] | 1 | [
"PUB00053562",
"PUB00053563"
] | [
"18705889",
"10361296"
] | [
"Papain-like cysteine proteases: key players at molecular battlefields employed by both plants and their invaders.",
"Characterization of the Pseudomonas syringae pv. tomato AvrRpt2 protein: demonstration of secretion and processing during bacterial pathogenesis."
] | [
2008,
1999
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Methanosarcina siciliae",
"unclassified sequences",
"uncultured Caudovirales phage"
] | [
1378,
11,
3,
4,
1
] | 5 | [] | [] | 0 | true | Family | Peptidase C70, AvrRpt2 | Peptidase C70, AvrRpt2 | Peptidase_C70_AvrRpt2 | 6 |
IPR022119 | 22,119 | Pseudomurein endoisopeptidase, C-terminal domain | Pei_C | Domain | 20 | false | false | This entry represents the C-terminal in Pseudomurein endoisopeptidase from Methanobacterium phage psiM2 (PeiP) and similar proteins from tailed bacteriophages and prokariotic phophages that belong to the group of peptidases C71. These peptidases have the catalytic triad C-H-D at the C-terminal end, a triad similar to t... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12386"
] | [
"Peptidase_C71"
] | [
20
] | 1 | [] | [] | [] | 0 | [
"8jx4",
"8z4f"
] | 2 | [
"PUB00061600"
] | [
"11934493"
] | [
"Pseudomurein endoisopeptidases PeiW and PeiP, two moderately related members of a novel family of proteases produced in Methanothermobacter strains."
] | [
2002
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Caudoviricetes",
"Methanobacteriaceae",
"Trichoderma asperellum (strain ATCC 204424 / CBS 433.97 / NBRC 101777)"
] | [
2,
6,
11,
1
] | 4 | [] | [] | 0 | true | Domain | Pseudomurein endoisopeptidase, C-terminal domain | Pseudomurein endoisopeptidase, C-terminal domain | Pei_C | 8 |
IPR022120 | 22,120 | Pestivirus nonstructural protein 2 | NS2 | Family | 727 | false | false | The pestivirus NS2 peptidase is responsible for single cleavage between NS2 and NS3 of the Bovine viral diarrhea virus 1 polyprotein, a cleavage that is correlated with cytopathogenicity [ ]. The peptidase is activated by its interaction with 'J-domain protein interacting with viral protein' Jiv [ ]. | [
"GO:0003968",
"GO:0004197",
"GO:0004252",
"GO:0016817",
"GO:0017111",
"GO:0070008"
] | [
"RNA-directed RNA polymerase activity",
"cysteine-type endopeptidase activity",
"serine-type endopeptidase activity",
"hydrolase activity, acting on acid anhydrides",
"ribonucleoside triphosphate phosphatase activity",
"serine-type exopeptidase activity"
] | [
"molecular_function",
"molecular_function",
"molecular_function",
"molecular_function",
"molecular_function",
"molecular_function"
] | 6 | [
"PFAM"
] | [
"PF12387"
] | [
"Peptidase_C74"
] | [
727
] | 1 | [
"EC",
"EC",
"EC",
"EC",
"EC",
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC"
] | [
"2.7.7.48",
"3.4.21.113",
"3.4.22.-",
"3.6.1.15",
"3.6.4.13",
"4.6.1.19",
"PWY-6545",
"PWY-7184",
"PWY-7185",
"PWY-7198",
"PWY-7210"
] | [
"EC:2.7.7.48",
"EC:3.4.21.113",
"EC:3.4.22.-",
"EC:3.6.1.15",
"EC:3.6.4.13",
"EC:4.6.1.19",
"METACYC:PWY-6545",
"METACYC:PWY-7184",
"METACYC:PWY-7185",
"METACYC:PWY-7198",
"METACYC:PWY-7210"
] | 11 | [] | 0 | [
"PUB00053564",
"PUB00072577"
] | [
"16432213",
"11533209"
] | [
"Dissection of a viral autoprotease elucidates a function of a cellular chaperone in proteolysis.",
"A cellular J-domain protein modulates polyprotein processing and cytopathogenicity of a pestivirus."
] | [
2006,
2001
] | 2 | [] | [] | 0 | 0 | null | [
"Orthornavirae"
] | [
727
] | 1 | [] | [] | 0 | true | Family | Pestivirus nonstructural protein 2 | Pestivirus nonstructural protein 2 | NS2 | 3 |
IPR022121 | 22,121 | Peptidase M73, camelysin | Peptidase_M73_camelysin | Family | 2,714 | false | false | Camelysin is a novel surface metallopeptidase from Bacillus cereus [ ]. Camelysin prefers cleavage sites in front of aliphatic and hydrophilic amino acid residues (-OH, -SO3H, amido group), and requires zinc for activity [ , ]. This entry also includes TasA, a major biofilm matrix component from Bacillus subtilis [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12389"
] | [
"Peptidase_M73"
] | [
2714
] | 1 | [] | [] | [] | 0 | [
"5of1",
"5of2",
"8aur"
] | 3 | [
"PUB00053483",
"PUB00053484",
"PUB00053485",
"PUB00089803"
] | [
"14688099",
"11566257",
"8520670",
"20080671"
] | [
"Camelysin is a novel surface metalloproteinase from Bacillus cereus.",
"The cell envelope-bound metalloprotease (camelysin) from Bacillus cereus is a possible pathogenic factor.",
"Unusual chromatographic behaviour and one-step purification of a novel membrane proteinase from Bacillus cereus.",
"Amyloid fibe... | [
2004,
2001,
1995,
2010
] | 4 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"unclassified sequences"
] | [
169,
2511,
34
] | 3 | [] | [] | 0 | true | Family | Peptidase M73, camelysin | Peptidase M73, camelysin | Peptidase_M73_camelysin | 7 |
IPR022122 | 22,122 | Protein FAM135 | DUF3657 | Family | 4,690 | false | false | This family is found in eukaryotes, and is approximately 60 amino acids in length. Proteins in this family contain a domain found in a group of putative lipases ( ). | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12394"
] | [
"DUF3657"
] | [
4690
] | 1 | [
"REACTOME",
"REACTOME"
] | [
"R-HSA-9696273",
"R-MMU-9696273"
] | [
"REACTOME:R-HSA-9696273",
"REACTOME:R-MMU-9696273"
] | 2 | [] | 0 | [] | [] | [] | [] | 0 | [
"IPR044294"
] | [] | 1 | 0 | 1 | [
"Eukaryota"
] | [
4690
] | 1 | [
"Arabidopsis thaliana",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
12,
21,
3,
5,
7,
5,
4,
20
] | 8 | true | Family | Protein FAM135 | Protein FAM135 | DUF3657 | 2 |
IPR022123 | 22,123 | Domain of unknown function DUF3658 | DUF3658 | Domain | 2,184 | false | false | This domain family is found in bacteria, and is approximately 110 amino acids in length. It is found in association with . There are two completely conserved residues (D and R) that may be functionally important. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12395"
] | [
"DUF3658"
] | [
2184
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Methanomicrobiaceae",
"Russula earlei",
"Siphoviridae sp. ctF2K4",
"unclassified sequences"
] | [
2166,
5,
1,
1,
11
] | 5 | [] | [] | 0 | true | Domain | Domain of unknown function DUF3658 | Domain of unknown function DUF3658 | DUF3658 | 1 |
IPR022124 | 22,124 | Protein of unknown function DUF3659 | DUF3659 | Domain | 1,666 | false | false | This domain family is found in bacteria and eukaryotes, and is approximately 70 amino acids in length. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12396"
] | [
"DUF3659"
] | [
1666
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Pseudomonadati"
] | [
1658,
8
] | 2 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)"
] | [
2
] | 1 | true | Domain | Protein of unknown function DUF3659 | Protein of unknown function DUF3659 | DUF3659 | 3 |
IPR022126 | 22,126 | S-locus, receptor kinase | S-locus_recpt_kinase | Domain | 824 | false | false | This domain family is found in eukaryotes, and is approximately 40 amino acids in length. The family is found in association with , , , . There is a conserved ELPL sequence motif. | [
"GO:0004674"
] | [
"protein serine/threonine kinase activity"
] | [
"molecular_function"
] | 1 | [
"PFAM"
] | [
"PF12398"
] | [
"DUF3660"
] | [
824
] | 1 | [
"EC"
] | [
"2.7.11.1"
] | [
"EC:2.7.11.1"
] | 1 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Mesangiospermae"
] | [
824
] | 1 | [
"Arabidopsis thaliana"
] | [
29
] | 1 | true | Domain | S-locus, receptor kinase | S-locus, receptor kinase | S-locus_recpt_kinase | 8 |
IPR022127 | 22,127 | Store-operated calcium entry regulator STIMATE/YPL162C | STIMATE/YPL162C | Family | 4,801 | false | false | This entry includes STIMATE from animals and uncharacterised vacuolar membrane protein YPL162C from budding yeasts. | [] | [] | [] | 0 | [
"PFAM",
"PANTHER"
] | [
"PF12400",
"PTHR31735"
] | [
"STIMATE",
""
] | [
4740,
4664
] | 2 | [] | [] | [] | 0 | [] | 0 | [
"PUB00076888"
] | [
"26322679"
] | [
"Proteomic mapping of ER-PM junctions identifies STIMATE as a regulator of Ca(2+) influx."
] | [
2015
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
4801
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)"
] | [
11,
3,
2,
1,
5,
1
] | 6 | true | Family | Store-operated calcium entry regulator STIMATE/YPL162C | Store-operated calcium entry regulator STIMATE/YPL162C | STIMATE/YPL162C | 4 |
IPR022128 | 22,128 | FhaA, N-terminal domain | FhaA_N | Domain | 5,148 | false | false | This domain can be found at the N terminus of FHA domain-containing protein Fha from Mycobacterium tuberculosis. The FHA (Fork Head Associated) domain is a phosphopeptide-specific binding domain that enables the protein to specifically bind to sequences containing phosphothreonine. FhaA is one of the major substrates o... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12401"
] | [
"FhaA_N"
] | [
5148
] | 1 | [] | [] | [] | 0 | [
"2lc0"
] | 1 | [
"PUB00057590",
"PUB00059641"
] | [
"22275220",
"22000520"
] | [
"A phosphorylated pseudokinase complex controls cell wall synthesis in mycobacteria.",
"Structural insight into the Mycobacterium tuberculosis Rv0020c protein and its interaction with the PknB kinase."
] | [
2012,
2011
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
5057,
2,
89
] | 3 | [] | [] | 0 | true | Domain | FhaA, N-terminal domain | FhaA, N-terminal domain | FhaA_N | 1 |
IPR022129 | 22,129 | Transcriptional repressor NocA-like | Tscrpt_rep_NocA-like | Family | 2,027 | false | false | This domain family is found in eukaryotes, and is typically between 42 and 57 amino acids in length. There is a conserved GAY sequence motif. There is a single completely conserved residue G that may be functionally important. Nlz1 self-associated via its C terminus, interacted with Nlz2, and bound to histone deacetyla... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12402"
] | [
"nlz1"
] | [
2027
] | 1 | [
"REACTOME",
"REACTOME"
] | [
"R-HSA-212436",
"R-MMU-212436"
] | [
"REACTOME:R-HSA-212436",
"REACTOME:R-MMU-212436"
] | 2 | [] | 0 | [
"PUB00054027"
] | [
"14550789"
] | [
"Nlz belongs to a family of zinc-finger-containing repressors and controls segmental gene expression in the zebrafish hindbrain."
] | [
2003
] | 1 | [] | [] | 0 | 0 | null | [
"Vertebrata"
] | [
2027
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
4,
4,
3,
5
] | 4 | true | Family | Transcriptional repressor NocA-like | Transcriptional repressor NocA-like | Tscrpt_rep_NocA-like | 5 |
IPR022130 | 22,130 | Paired-box protein 2 C-terminal | Pax2_C | Domain | 4,193 | false | false | This domain is found in the C terminus of the paired-box protein 2, which is a transcription factor involved in embryonic development and organogenesis. It is approximately 110 amino acids in length and is found in association with . | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12403"
] | [
"Pax2_C"
] | [
4193
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-8939245",
"R-HSA-9761174",
"R-HSA-9830364",
"R-HSA-9830674",
"R-MMU-8939245"
] | [
"REACTOME:R-HSA-8939245",
"REACTOME:R-HSA-9761174",
"REACTOME:R-HSA-9830364",
"REACTOME:R-HSA-9830674",
"REACTOME:R-MMU-8939245"
] | 5 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Chordata"
] | [
4193
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
58,
21,
15,
16
] | 4 | true | Domain | Paired-box protein 2 C-terminal | Paired-box protein 2 C-terminal | Pax2_C | 2 |
IPR022131 | 22,131 | Protein of unknown function DUF3664, surface protein | DUF3664 | Family | 73 | false | false | This family of proteins is found in eukaryotes. Proteins in this family are typically between 131 and 312 amino acids in length. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12406"
] | [
"DUF3664"
] | [
73
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Theileria"
] | [
73
] | 1 | [] | [] | 0 | true | Family | Protein of unknown function DUF3664, surface protein | Protein of unknown function DUF3664, surface protein | DUF3664 | 3 |
IPR022132 | 22,132 | Homeobox protein | Abdominal-A | Family | 519 | false | false | This domain family is found in eukaryotes, and is approximately 30 amino acids in length. The family is found in association with . This family is a homeobox protein involved in differentiation of embryonic cells to form the abdominal region. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12407"
] | [
"Abdominal-A"
] | [
519
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Panarthropoda"
] | [
519
] | 1 | [
"Drosophila melanogaster"
] | [
2
] | 1 | true | Family | Homeobox protein | Homeobox protein | Abdominal-A | 4 |
IPR022133 | 22,133 | Ribose-5-phosphate isomerase, C-terminal | Ribose_5_isomerase_C | Domain | 1,745 | false | false | This domain is found in bacteria, and is approximately 50 amino acids in length. It is found in association with and contains two completely conserved residues (D and F) that may be functionally important. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12408"
] | [
"DUF3666"
] | [
1745
] | 1 | [] | [] | [] | 0 | [
"2ppw",
"3c5y",
"3ono",
"4u8e",
"4u8f"
] | 5 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"metagenomes"
] | [
1742,
3
] | 2 | [] | [] | 0 | true | Domain | Ribose-5-phosphate isomerase, C-terminal | Ribose-5-phosphate isomerase, C-terminal | Ribose_5_isomerase_C | 4 |
IPR022135 | 22,135 | Distal-less-like homeobox protein, N-terminal domain | Distal-less_N | Domain | 2,588 | false | false | This domain is found in eukaryotes, and is approximately 80 amino acids in length. It is found in association with . It is found at the N terminus of a homeobox protein involved in embryonic development and adult neural regeneration [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12413"
] | [
"DLL_N"
] | [
2588
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-8939902",
"R-HSA-9834899",
"R-HSA-9938206"
] | [
"REACTOME:R-HSA-8939902",
"REACTOME:R-HSA-9834899",
"REACTOME:R-HSA-9938206"
] | 3 | [] | 0 | [
"PUB00056894"
] | [
"8798159"
] | [
"A Distal-less-like gene is induced in the regenerating central nervous system of the urodele Pleurodeles waltl."
] | [
1996
] | 1 | [] | [] | 0 | 0 | null | [
"Bilateria"
] | [
2588
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
9,
7,
8,
9
] | 5 | true | Domain | Distal-less-like homeobox protein, N-terminal domain | Distal-less-like homeobox protein, N-terminal domain | Distal-less_N | 7 |
IPR022136 | 22,136 | Domain of unknown function DUF3668 | DUF3668 | Domain | 1,706 | false | false | This domain is found in a number of proteins, including the Cep120 protein which is associated with centriole structure and function [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12416"
] | [
"DUF3668"
] | [
1706
] | 1 | [] | [] | [] | 0 | [
"6ewg",
"6ewh",
"6ewi"
] | 3 | [
"PUB00057426"
] | [
"20956381"
] | [
"Cep120 is asymmetrically localized to the daughter centriole and is essential for centriole assembly."
] | [
2010
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1706
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
2,
8,
1,
3
] | 5 | true | Domain | Domain of unknown function DUF3668 | Domain of unknown function DUF3668 | DUF3668 | 6 |
IPR022137 | 22,137 | Zinc finger protein, DUF3669 domain | Znf_prot_DUF3669 | Domain | 1,381 | false | false | This domain can be found in a group of eukaryotic zinc finger proteins. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12417"
] | [
"DUF3669"
] | [
1381
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1381
] | 1 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)"
] | [
2
] | 1 | true | Domain | Zinc finger protein, DUF3669 domain | Zinc finger protein, DUF3669 domain | Znf_prot_DUF3669 | 1 |
IPR022138 | 22,138 | Domain of unknown function DUF3670 | DUF3670 | Domain | 6,458 | false | false | This entry describes a domain of unknown function found in putative ATP-dependent helicase/translocase YwqA and related putative helicases. It is mainly found in bacteria. This domain is often found in association with and . YwqA has not been functionally characterised; it was first identified in Bacillus subtilis (str... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12419"
] | [
"DUF3670"
] | [
6458
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00054121"
] | [
"9384377"
] | [
"The complete genome sequence of the gram-positive bacterium Bacillus subtilis."
] | [
1997
] | 1 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
71,
6298,
17,
72
] | 4 | [] | [] | 0 | true | Domain | Domain of unknown function DUF3670 | Domain of unknown function DUF3670 | DUF3670 | 2 |
IPR022139 | 22,139 | Fam-L/Fam-M-like, plasmodium | Fam-L/Fam-M-like_plasmodium | Family | 3,709 | false | false | This entry represents a large set of plasmodium proteins found in high copy number in subtelomeric repeats, including Fam-L and Fam-M proteins [ ]. It has been suggested that these proteins may pair to form heterodimers [ ]. Structure prediction suggests these proteins are related to RH5 and therefore may also have an ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12420"
] | [
"DUF3671"
] | [
3709
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00151585"
] | [
"28117441"
] | [
"Plasmodium malariae and P. ovale genomes provide insights into malaria parasite evolution."
] | [
2017
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
3709
] | 1 | [] | [] | 0 | true | Family | Fam-L/Fam-M-like, plasmodium | Fam-L/Fam-M-like, plasmodium | Fam-L/Fam-M-like_plasmodium | 2 |
IPR022140 | 22,140 | Kinesin-like KIF1-type | Kinesin-like_KIF1-typ | Domain | 14,006 | false | false | This domain is found in kinesin-like proteins and is approximately 50 amino acids in length. It is found in some kinesin-3 family members, such as KIF1, KIF13, KIF28 [ ] and unc-104 [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12423"
] | [
"KIF1B"
] | [
14006
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-CEL-6811434",
"R-CEL-983189",
"R-DME-6811434",
"R-DME-983189",
"R-HSA-390471",
"R-HSA-6811434",
"R-HSA-983189",
"R-MMU-2132295",
"R-MMU-6811434",
"R-MMU-983189",
"R-RNO-2132295",
"R-RNO-6811434",
"R-RNO-983189"
] | [
"REACTOME:R-CEL-6811434",
"REACTOME:R-CEL-983189",
"REACTOME:R-DME-6811434",
"REACTOME:R-DME-983189",
"REACTOME:R-HSA-390471",
"REACTOME:R-HSA-6811434",
"REACTOME:R-HSA-983189",
"REACTOME:R-MMU-2132295",
"REACTOME:R-MMU-6811434",
"REACTOME:R-MMU-983189",
"REACTOME:R-RNO-2132295",
"REACTOME:R-R... | 13 | [
"5b64",
"7wrg"
] | 2 | [
"PUB00075477",
"PUB00075478"
] | [
"17643120",
"24706892"
] | [
"A Drosophila kinesin required for synaptic bouton formation and synaptic vesicle transport.",
"Dimerization of mammalian kinesin-3 motors results in superprocessive motion."
] | [
2007,
2014
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
14006
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus"
] | [
5,
126,
12,
34,
21,
2,
24
] | 7 | true | Domain | Kinesin-like KIF1-type | Kinesin-like KIF1-type | Kinesin-like_KIF1-typ | 3 |
IPR022141 | 22,141 | Plasma membrane calcium transporting P-type ATPase, C-terminal | ATP_Ca_trans_C | Domain | 9,788 | false | false | This domain represents the C terminus of a calcium transporting ATPase located in the plasma membrane [ ]. This domain is found in eukaryotes, and is approximately 60 amino acids in length. It contains a conserved QTQ sequence motif. | [
"GO:0005388"
] | [
"P-type calcium transporter activity"
] | [
"molecular_function"
] | 1 | [
"PFAM"
] | [
"PF12424"
] | [
"ATP_Ca_trans_C"
] | [
9788
] | 1 | [
"EC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"7.2.2.10",
"R-BTA-418359",
"R-BTA-5578775",
"R-BTA-936837",
"R-GGA-418359",
"R-GGA-5578775",
"R-GGA-936837",
"R-HSA-418359",
"R-HSA-5578775",
"R-HSA-936837",
"R-HSA-9662360",
"R-HSA-9662361",
"R-MMU-418359",
"R-MMU-5578775",
"R-MMU-936837",
"R-RNO-418359",
"R-RNO-5578775",
"R-RNO-... | [
"EC:7.2.2.10",
"REACTOME:R-BTA-418359",
"REACTOME:R-BTA-5578775",
"REACTOME:R-BTA-936837",
"REACTOME:R-GGA-418359",
"REACTOME:R-GGA-5578775",
"REACTOME:R-GGA-936837",
"REACTOME:R-HSA-418359",
"REACTOME:R-HSA-5578775",
"REACTOME:R-HSA-936837",
"REACTOME:R-HSA-9662360",
"REACTOME:R-HSA-9662361",... | 18 | [
"1cff",
"2kne",
"6a69",
"9gsd",
"9gse",
"9gsf",
"9gsg",
"9gsh",
"9gsi",
"9gsy",
"9gtb"
] | 11 | [
"PUB00056892"
] | [
"19218514"
] | [
"Plasma membrane calcium ATPase required for semicircular canal formation and otolith growth in the zebrafish inner ear."
] | [
2009
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Thermosporothrix"
] | [
9786,
2
] | 2 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
8,
74,
7,
29,
25,
26
] | 6 | true | Domain | Plasma membrane calcium transporting P-type ATPase, C-terminal | Plasma membrane calcium transporting P-type ATPase, C-terminal | ATP_Ca_trans_C | 3 |
IPR022142 | 22,142 | Protein of unknown function DUF3673 | DUF3673 | Family | 40 | false | false | This domain family is found in eukaryotes, and is approximately 50 amino acids in length. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12425"
] | [
"DUF3673"
] | [
40
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Oryza"
] | [
40
] | 1 | [
"Oryza sativa subsp. japonica"
] | [
22
] | 1 | true | Family | Protein of unknown function DUF3673 | Protein of unknown function DUF3673 | DUF3673 | 6 |
IPR022143 | 22,143 | Protein of unknown function DUF3675 | DUF3675 | Family | 4,906 | false | false | This domain family is found in eukaryotes, and is approximately 120 amino acids in length. The family is found in association with . There are two completely conserved residues (R and L) that may be functionally important. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12428"
] | [
"DUF3675"
] | [
4906
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [
"IPR033275"
] | [] | 1 | 0 | 1 | [
"Viridiplantae"
] | [
4906
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
47,
29,
68
] | 3 | true | Family | Protein of unknown function DUF3675 | Protein of unknown function DUF3675 | DUF3675 | 8 |
IPR022144 | 22,144 | Domain of unknown function DUF3676 | DUF3676 | Domain | 236 | false | false | This domain is found in eukaryotes, and is approximately 230 amino acids in length. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12429"
] | [
"DUF3676"
] | [
236
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Trypanosoma cruzi"
] | [
236
] | 1 | [] | [] | 0 | true | Domain | Domain of unknown function DUF3676 | Domain of unknown function DUF3676 | DUF3676 | 4 |
IPR022145 | 22,145 | Integrator complex subunit 1, RPB2-binding domain | INTS1_RPB2-bd | Domain | 1,988 | false | false | Integrator (INT) complex is involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing [ ]. It binds the C-terminal domain (CTD) of RNA polymerase II (Pol II) and functions as an RNA endonuclease to cleave different classes of RNAs, regulating the transcription of both p... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12432"
] | [
"INTS1_RP2B-bd"
] | [
1988
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-DME-6807505",
"R-HSA-6807505",
"R-MMU-6807505"
] | [
"REACTOME:R-DME-6807505",
"REACTOME:R-HSA-6807505",
"REACTOME:R-MMU-6807505"
] | 3 | [
"7cun",
"7pks",
"7ycx",
"8rbx",
"8rbz",
"8rc4",
"8yjb",
"9vd9"
] | 8 | [
"PUB00045283",
"PUB00152015",
"PUB00153137"
] | [
"16239144",
"33243860",
"34762484"
] | [
"Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II.",
"Identification of Integrator-PP2A complex (INTAC), an RNA polymerase II phosphatase.",
"Structural basis of Integrator-mediated transcription regulation."
] | [
2005,
2020,
2021
] | 3 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1988
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
3,
1,
3,
4,
6
] | 6 | true | Domain | Integrator complex subunit 1, RPB2-binding domain | Integrator complex subunit 1, RPB2-binding domain | INTS1_RPB2-bd | 7 |
IPR022146 | 22,146 | Protein of unknown function DUF3678 | DUF3678 | Family | 85 | false | false | This domain family is found in eukaryotes, and is approximately 40 amino acids in length. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12435"
] | [
"DUF3678"
] | [
85
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Oryza"
] | [
85
] | 1 | [
"Oryza sativa subsp. japonica"
] | [
24
] | 1 | true | Family | Protein of unknown function DUF3678 | Protein of unknown function DUF3678 | DUF3678 | 6 |
IPR022147 | 22,147 | Glutamine synthetase type III N-terminal | GSIII_N | Domain | 6,192 | false | false | This domain is found in the N terminus of glutamine synthetase type III in bacteria and eukaryotes, and is approximately 160 amino acids in length. It is found in association with . Glutamine synthetase type III is one of the enzymes responsible for generation of glutamine through conversion glutamate to glutamine by t... | [
"GO:0004356"
] | [
"glutamine synthetase activity"
] | [
"molecular_function"
] | 1 | [
"PFAM"
] | [
"PF12437"
] | [
"GSIII_N"
] | [
6192
] | 1 | [
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC"
] | [
"6.3.1.2",
"PWY-6963",
"PWY-6964",
"PWY-8291",
"PWY-8294"
] | [
"EC:6.3.1.2",
"METACYC:PWY-6963",
"METACYC:PWY-6964",
"METACYC:PWY-8291",
"METACYC:PWY-8294"
] | 5 | [
"3o6x",
"7u6o"
] | 2 | [
"PUB00056891"
] | [
"16237031"
] | [
"Biochemical and mutational analysis of glutamine synthetase type III from the rumen anaerobe Ruminococcus albus 8."
] | [
2005
] | 1 | [
"IPR008147"
] | [] | 1 | 0 | 1 | [
"Bacteria",
"Eukaryota",
"Methanomassiliicoccales",
"metagenomes"
] | [
5556,
549,
3,
84
] | 4 | [] | [] | 0 | true | Domain | Glutamine synthetase type III N-terminal | Glutamine synthetase type III N-terminal | GSIII_N | 9 |
IPR022148 | 22,148 | CopG antitoxin | CopG_antitoxin | Family | 1,924 | false | false | CopG antitoxin is a member of a type II toxin-antitoxin system family found mainly in bacteria. Most antitoxins encoded by the relBE and parDE loci belong to the MetJ/Arc/CopG family of dimeric proteins which bind DNA through N-terminal ribbon-helix-helix (RHH) motifs [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12441"
] | [
"CopG_antitoxin"
] | [
1924
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00075548"
] | [
"15864262"
] | [
"Prokaryotic toxin-antitoxin stress response loci."
] | [
2005
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Geodia barretti",
"Methanomicrobia",
"Viruses",
"unclassified sequences"
] | [
1847,
1,
15,
2,
59
] | 5 | [] | [] | 0 | true | Family | CopG antitoxin | CopG antitoxin | CopG_antitoxin | 5 |
IPR022149 | 22,149 | Protein of unknown function DUF3681 | DUF3681 | Family | 671 | false | false | This family of proteins is found in eukaryotes. Proteins in this family are typically between 112 and 212 amino acids in length. There is a single completely conserved residue G that may be functionally important. | [] | [] | [] | 0 | [
"PFAM",
"PANTHER"
] | [
"PF12442",
"PTHR33530"
] | [
"DUF3681",
""
] | [
634,
613
] | 2 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"commelinids"
] | [
671
] | 1 | [
"Oryza sativa subsp. japonica"
] | [
49
] | 1 | true | Family | Protein of unknown function DUF3681 | Protein of unknown function DUF3681 | DUF3681 | 6 |
IPR022150 | 22,150 | AKNA domain | AKNA_dom | Domain | 953 | false | false | This domain can be found in microtubule organization protein AKNA (also known as AT-hook-containing transcription factor) in eukaryotes, and is approximately 110 amino acids in length. AKNA which regulates the expression of the costimulatory molecules on lymphocytes and lays a key role in cell delamination by regulatin... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12443"
] | [
"AKNA"
] | [
953
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00092871",
"PUB00094438"
] | [
"30787442",
"26292654"
] | [
"The centrosome protein AKNA regulates neurogenesis via microtubule organization.",
"CNV Analysis Associates AKNAD1 with Type-2 Diabetes in Jordan Subpopulations."
] | [
2019,
2015
] | 2 | [] | [] | 0 | 0 | null | [
"Deuterostomia"
] | [
953
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
10,
5,
5
] | 3 | true | Domain | AKNA domain | AKNA domain | AKNA_dom | 9 |
IPR022151 | 22,151 | Sox developmental protein N-terminal | Sox_N | Domain | 3,545 | false | false | This domain is found in eukaryotes, and is typically between 69 and 88 amino acids in length. It is found in association with . It contains two conserved sequence motifs: YDW and PVR. It is found in Sox8 [ ], Sox9 [ ] and Sox10 [ ] proteins, which have structural similarity. Sox proteins are involved in developmental p... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12444"
] | [
"Sox_N"
] | [
3545
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-GGA-3769402",
"R-GGA-8878166",
"R-GGA-9856649",
"R-HSA-3769402",
"R-HSA-8878166",
"R-HSA-9619665",
"R-HSA-9690406",
"R-HSA-9764302",
"R-HSA-9824585",
"R-HSA-9856649",
"R-HSA-9925561",
"R-HSA-9925563",
"R-HSA-9937080",
"R-MMU-3769402",
"R-MMU-8878166",
"R-MMU-9856649",
"R-RNO-37694... | [
"REACTOME:R-GGA-3769402",
"REACTOME:R-GGA-8878166",
"REACTOME:R-GGA-9856649",
"REACTOME:R-HSA-3769402",
"REACTOME:R-HSA-8878166",
"REACTOME:R-HSA-9619665",
"REACTOME:R-HSA-9690406",
"REACTOME:R-HSA-9764302",
"REACTOME:R-HSA-9824585",
"REACTOME:R-HSA-9856649",
"REACTOME:R-HSA-9925561",
"REACTOM... | 22 | [] | 0 | [
"PUB00056888",
"PUB00056889",
"PUB00056890"
] | [
"16943273",
"15818483",
"9412504"
] | [
"Functional analysis of Sox8 during neural crest development in Xenopus.",
"Divergent expression patterns of Sox9 duplicates in teleosts indicate a lineage specific subfunctionalization.",
"Sox10, a novel transcriptional modulator in glial cells."
] | [
2006,
2005,
1998
] | 3 | [] | [] | 0 | 0 | null | [
"Eumetazoa"
] | [
3545
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
7,
3,
13,
12,
8
] | 5 | true | Domain | Sox developmental protein N-terminal | Sox developmental protein N-terminal | Sox_N | 8 |
IPR022152 | 22,152 | Protein of unknown function DUF3682 | DUF3682 | Family | 161 | false | false | This domain family is found in eukaryotes, and is typically between 125 and 136 amino acids in length. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12446"
] | [
"DUF3682"
] | [
161
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
161
] | 1 | [] | [] | 0 | true | Family | Protein of unknown function DUF3682 | Protein of unknown function DUF3682 | DUF3682 | 5 |
IPR022153 | 22,153 | Protein of unknown function DUF3683 | DUF3683 | Family | 1,799 | false | false | This domain family is found in bacteria, and is approximately 120 amino acids in length. The family is found in association with , , . | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12447"
] | [
"DUF3683"
] | [
1799
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Opisthokonta",
"Pseudomonadati",
"metagenomes"
] | [
3,
1747,
49
] | 3 | [] | [] | 0 | true | Family | Protein of unknown function DUF3683 | Protein of unknown function DUF3683 | DUF3683 | 8 |
IPR022154 | 22,154 | Trafficking kinesin-binding protein, C-terminal | TRAK1/2_C | Domain | 5,844 | false | false | This domain can be found at the C terminus of the eukaryotic trafficking kinesin-binding proteins, including TRAK1 and TRAK2. TRAK1 binds to both kinesin-1 and dynein/dynactin, is prominently localized in axons, and is needed for normal axon outgrowth, whereas TRAK2 predominantly interacts with dynein/dynactin, is more... | [] | [] | [] | 0 | [
"PFAM",
"SMART"
] | [
"PF12448",
"SM01423"
] | [
"Milton",
"Milton"
] | [
5835,
5475
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-DME-9013419",
"R-DME-9013425",
"R-HSA-6802952",
"R-HSA-9013419",
"R-HSA-9013425",
"R-MMU-9013419",
"R-MMU-9013425",
"R-RNO-9013419"
] | [
"REACTOME:R-DME-9013419",
"REACTOME:R-DME-9013425",
"REACTOME:R-HSA-6802952",
"REACTOME:R-HSA-9013419",
"REACTOME:R-HSA-9013425",
"REACTOME:R-MMU-9013419",
"REACTOME:R-MMU-9013425",
"REACTOME:R-RNO-9013419"
] | 8 | [
"9dgv",
"9e2p"
] | 2 | [
"PUB00094282"
] | [
"23395375"
] | [
"TRAK/Milton motor-adaptor proteins steer mitochondrial trafficking to axons and dendrites."
] | [
2013
] | 1 | [] | [] | 0 | 0 | null | [
"Candidatus Kutchimonas denitrificans",
"Opisthokonta"
] | [
1,
5843
] | 2 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
47,
5,
16,
14,
12
] | 6 | true | Domain | Trafficking kinesin-binding protein, C-terminal | Trafficking kinesin-binding protein, C-terminal | TRAK1/2_C | 4 |
IPR022155 | 22,155 | Protein of unknown function DUF3684 | DUF3684 | Family | 2,370 | false | false | This domain family is found in eukaryotes, and is typically between 1072 and 1090 amino acids in length. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12449"
] | [
"DUF3684"
] | [
2370
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Pseudomonas fluorescens"
] | [
2369,
1
] | 2 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)"
] | [
1
] | 1 | true | Family | Protein of unknown function DUF3684 | Protein of unknown function DUF3684 | DUF3684 | 3 |
IPR022156 | 22,156 | Uncharacterised protein YfbK, N-terminal | Uncharacterised_YfbK_N | Domain | 4,900 | false | false | This domain is found in bacteria, and is approximately 100 amino acids in length. It is found in association with a von Willebrand factor type A domain ( ). It contains two conserved sequence motifs: STF and DVD and two completely conserved residues (E and N) that may be functionally important. It is found in uncharact... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12450"
] | [
"vWF_A"
] | [
4900
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
4856,
10,
34
] | 3 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Domain | Uncharacterised protein YfbK, N-terminal | Uncharacterised protein YfbK, N-terminal | Uncharacterised_YfbK_N | 9 |
IPR022157 | 22,157 | Dynein associated protein | Dynactin | Domain | 5,915 | false | false | This domain is found in eukaryotes, and is approximately 280 amino acids in length. The family is found in association with . There is a single completely conserved residue E that may be functionally important. Dynactin has been associated with Dynein, a kinesin protein which is involved in organelle transport, mitotic... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12455"
] | [
"Dynactin"
] | [
5915
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-DME-3371497",
"R-DME-6807878",
"R-DME-6811436",
"R-HSA-2132295",
"R-HSA-2565942",
"R-HSA-3371497",
"R-HSA-380259",
"R-HSA-380270",
"R-HSA-380284",
"R-HSA-380320",
"R-HSA-381038",
"R-HSA-5620912",
"R-HSA-6807878",
"R-HSA-6811436",
"R-HSA-8854518",
"R-HSA-9725370",
"R-MMU-2132295",
... | [
"REACTOME:R-DME-3371497",
"REACTOME:R-DME-6807878",
"REACTOME:R-DME-6811436",
"REACTOME:R-HSA-2132295",
"REACTOME:R-HSA-2565942",
"REACTOME:R-HSA-3371497",
"REACTOME:R-HSA-380259",
"REACTOME:R-HSA-380270",
"REACTOME:R-HSA-380284",
"REACTOME:R-HSA-380320",
"REACTOME:R-HSA-381038",
"REACTOME:R-H... | 48 | [
"6znl",
"7z8f",
"8pqw",
"8pqz",
"8pr0",
"8pr5",
"8ptk",
"9b7j",
"9dgr",
"9dgs",
"9dgt",
"9dgu",
"9dgv"
] | 13 | [
"PUB00066298"
] | [
"9235942"
] | [
"Phosphorylation by p34cdc2 protein kinase regulates binding of the kinesin-related motor HsEg5 to the dynactin subunit p150."
] | [
1997
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"bird metagenome"
] | [
5914,
1
] | 2 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus"
] | [
5,
16,
3,
10,
7,
1,
12
] | 7 | true | Domain | Dynein associated protein | Dynein associated protein | Dynactin | 9 |
IPR022158 | 22,158 | Inositol phosphatase | Inositol_phosphatase | Domain | 5,532 | false | false | This domain is found in eukaryotes, and is approximately 120 amino acids in length. It is often found in association with . It is found in hSac2, which functions as an inositol polyphosphate 5-phosphatase. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12456"
] | [
"hSac2"
] | [
5532
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-DRE-1660516",
"R-HSA-1660516",
"R-MMU-1660516"
] | [
"REACTOME:R-DRE-1660516",
"REACTOME:R-HSA-1660516",
"REACTOME:R-MMU-1660516"
] | 3 | [
"4xuu"
] | 1 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
5532
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus"
] | [
3,
4,
5,
11,
4,
1,
13
] | 7 | true | Domain | Inositol phosphatase | Inositol phosphatase | Inositol_phosphatase | 8 |
IPR022159 | 22,159 | Tuftelin interacting protein, N-terminal domain | STIP/TFIP11_N | Domain | 3,258 | false | false | This domain is found in septin and tuftelin-interacting protein (STIP) and tuftelin-interacting protein 11 (TFIP11). STIP is essential for embryogenesis in Caenorhabditis elegans [ ]. Tuftelin-interacting protein 11 is a component of the spliceosome involved in spliceosome disassembly [ ]. TFIP11 was first identified i... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12457"
] | [
"TIP_N"
] | [
3258
] | 1 | [
"REACTOME"
] | [
"R-HSA-72163"
] | [
"REACTOME:R-HSA-72163"
] | 1 | [
"8ro0",
"8ro1",
"8ro2",
"9l5r"
] | 4 | [
"PUB00056831",
"PUB00056835",
"PUB00070239"
] | [
"11063033",
"17289020",
"19857462"
] | [
"Identification of tuftelin- and amelogenin-interacting proteins using the yeast two-hybrid system.",
"Characterization of STIP, a multi-domain nuclear protein, highly conserved in metazoans, and essential for embryogenesis in Caenorhabditis elegans.",
"Identification of a novel nuclear localization signal and ... | [
1998,
2007,
2009
] | 3 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
3258
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
7,
2,
4,
2,
7,
5,
1,
3,
2,
3
] | 10 | true | Domain | Tuftelin interacting protein, N-terminal domain | Tuftelin interacting protein, N-terminal domain | STIP/TFIP11_N | 9 |
IPR022160 | 22,160 | Spiroplasma phage 1-C74, Orf1 | Phage_1-C74_Orf1 | Family | 348 | false | false | This entry is represented by Spiroplasma phage 1-C74, Orf1. There is a conserved YRW sequence motif and a single completely conserved residue Y that may be functionally important. The characteristics of the protein distribution suggest prophage matches in addition to the phage matches. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12461"
] | [
"DUF3688"
] | [
348
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Lasius niger",
"Plectroviridae",
"Spiroplasma"
] | [
1,
4,
343
] | 3 | [] | [] | 0 | true | Family | Spiroplasma phage 1-C74, Orf1 | Spiroplasma phage 1-C74, Orf1 | Phage_1-C74_Orf1 | 6 |
IPR022161 | 22,161 | DNA helicase IV, N-terminal domain | Helicase_IV_N | Domain | 2,310 | false | false | This domain is found in DNA helicase IV in bacteria. It is approximately 170 amino acids in length and is found at the N terminus of . DNA helicase IV catalyses the unwinding of duplex DNA in the 3' to 5' direction with respect to the bound single strand in a reaction that is dependent upon the hydrolysis of ATP [ , ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12462"
] | [
"Helicase_IV_N"
] | [
2310
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00056884",
"PUB00056886"
] | [
"2542273",
"2822720"
] | [
"The molecular cloning of the gene encoding the Escherichia coli 75-kDa helicase and the determination of its nucleotide sequence and gentic map position.",
"Purification and characterization of a new DNA-dependent ATPase with helicase activity from Escherichia coli."
] | [
1989,
1987
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"marine sediment metagenome"
] | [
2304,
5,
1
] | 3 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Domain | DNA helicase IV, N-terminal domain | DNA helicase IV, N-terminal domain | Helicase_IV_N | 6 |
IPR022162 | 22,162 | Short transient receptor potential channel 4-associated protein | TRPC4AP | Family | 1,925 | false | false | TRPC4AP is a substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control [ ]. | [
"GO:0006511",
"GO:0031464"
] | [
"ubiquitin-dependent protein catabolic process",
"Cul4A-RING E3 ubiquitin ligase complex"
] | [
"biological_process",
"cellular_component"
] | 2 | [
"PFAM",
"PANTHER"
] | [
"PF12463",
"PTHR31743"
] | [
"DUF3689",
""
] | [
1807,
1914
] | 2 | [
"REACTOME",
"REACTOME"
] | [
"R-HSA-3295583",
"R-MMU-3295583"
] | [
"REACTOME:R-HSA-3295583",
"REACTOME:R-MMU-3295583"
] | 2 | [] | 0 | [
"PUB00086603"
] | [
"20551172"
] | [
"Myc protein is stabilized by suppression of a novel E3 ligase complex in cancer cells."
] | [
2010
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1925
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
4,
5,
7,
5
] | 4 | true | Family | Short transient receptor potential channel 4-associated protein | Short transient receptor potential channel 4-associated protein | TRPC4AP | 4 |
IPR022163 | 22,163 | GTP cyclohydrolase N-terminal | GTP_CH_N | Domain | 2,761 | false | false | This domain is found in bacteria and eukaryotes, and is approximately 190 amino acids in length. It is the N-terminal domain of GTP cyclohydrolase, the rate limiting enzyme in the synthesis of tetrahydrobiopterin [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12471"
] | [
"GTP_CH_N"
] | [
2761
] | 1 | [] | [] | [] | 0 | [
"7eev",
"7ej3"
] | 2 | [
"PUB00056883"
] | [
"19762783"
] | [
"Identification and functional characterization of phosphorylation sites on GTP cyclohydrolase I."
] | [
2009
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"ecological metagenomes"
] | [
828,
1925,
8
] | 3 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
1,
1
] | 2 | true | Domain | GTP cyclohydrolase N-terminal | GTP cyclohydrolase N-terminal | GTP_CH_N | 9 |
IPR022164 | 22,164 | Kinesin-like | Kinesin-like | Domain | 17,019 | false | false | This domain is found in eukaryotes, and is typically between 131 and 151 amino acids in length. There is a single completely conserved residue W that may be functionally important. It is found in some kinesin-like proteins and in Rab GTPase-activating protein 1. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12473"
] | [
"DUF3694"
] | [
17019
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-CEL-6811434",
"R-CEL-8854214",
"R-CEL-983189",
"R-DME-6811434",
"R-DME-983189",
"R-HSA-390471",
"R-HSA-6811434",
"R-HSA-8854214",
"R-HSA-983189",
"R-MMU-2132295",
"R-MMU-6811434",
"R-MMU-8854214",
"R-MMU-983189",
"R-RNO-2132295",
"R-RNO-6811434",
"R-RNO-983189"
] | [
"REACTOME:R-CEL-6811434",
"REACTOME:R-CEL-8854214",
"REACTOME:R-CEL-983189",
"REACTOME:R-DME-6811434",
"REACTOME:R-DME-983189",
"REACTOME:R-HSA-390471",
"REACTOME:R-HSA-6811434",
"REACTOME:R-HSA-8854214",
"REACTOME:R-HSA-983189",
"REACTOME:R-MMU-2132295",
"REACTOME:R-MMU-6811434",
"REACTOME:R-... | 16 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
17019
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus"
] | [
5,
132,
15,
44,
26,
2,
35
] | 7 | true | Domain | Kinesin-like | Kinesin-like | Kinesin-like | 6 |
IPR022165 | 22,165 | Polo kinase kinase | PKK | Family | 4,643 | false | false | This domain family is found in eukaryotes, and is approximately 140 amino acids in length. The family is found in association with . Polo-like kinase 1 (Plx1) is essential during mitosis for the activation of Cdc25C, for spindle assembly, and for cyclin B degradation. This family is Polo kinase kinase (PKK) which phosp... | [
"GO:0004674"
] | [
"protein serine/threonine kinase activity"
] | [
"molecular_function"
] | 1 | [
"PFAM"
] | [
"PF12474"
] | [
"PKK"
] | [
4643
] | 1 | [
"EC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"2.7.11.1",
"R-DRE-6798695",
"R-DRE-8980692",
"R-GGA-6798695",
"R-GGA-8980692",
"R-GGA-9013026",
"R-GGA-9013106",
"R-HSA-6798695",
"R-HSA-8980692",
"R-HSA-9013026",
"R-HSA-9013106",
"R-MMU-6798695",
"R-MMU-8980692",
"R-MMU-9013026",
"R-MMU-9013106",
"R-RNO-6798695",
"R-RNO-8980692",
... | [
"EC:2.7.11.1",
"REACTOME:R-DRE-6798695",
"REACTOME:R-DRE-8980692",
"REACTOME:R-GGA-6798695",
"REACTOME:R-GGA-8980692",
"REACTOME:R-GGA-9013026",
"REACTOME:R-GGA-9013106",
"REACTOME:R-HSA-6798695",
"REACTOME:R-HSA-8980692",
"REACTOME:R-HSA-9013026",
"REACTOME:R-HSA-9013106",
"REACTOME:R-MMU-679... | 18 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Opisthokonta",
"Peribacillus deserti"
] | [
4642,
1
] | 2 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
9,
9,
4,
6,
11
] | 6 | true | Family | Polo kinase kinase | Polo kinase kinase | PKK | 8 |
IPR022166 | 22,166 | UBAP2/protein lingerer | UBAP2/Lig | Family | 5,219 | false | false | This entry includes ubiquitin-associated protein 2 (UBAP2) from humans and protein lingerer (lig) from Drosophila melanogaster. Lig is a cytoplasmic protein involved in initiation and termination of copulation [ ]. Lig can act as a growth suppressor that associates with the RNA-binding proteins Fragile X messenger ribo... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12478"
] | [
"UBAP2-Lig"
] | [
5219
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00069369",
"PUB00092497"
] | [
"23874212",
"12524348"
] | [
"The RNA-binding proteins FMR1, rasputin and caprin act together with the UBA protein lingerer to restrict tissue growth in Drosophila melanogaster.",
"lingerer, a Drosophila gene involved in initiation and termination of copulation, encodes a set of novel cytoplasmic proteins."
] | [
2013,
2002
] | 2 | [] | [] | 0 | 0 | null | [
"Opisthokonta"
] | [
5219
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
35,
7,
15,
10,
12
] | 5 | true | Family | UBAP2/protein lingerer | UBAP2/protein lingerer | UBAP2/Lig | 1 |
IPR022167 | 22,167 | Protein of unknown function DUF3698 | DUF3698 | Family | 31 | false | false | This domain family is found in eukaryotes, and is typically between 89 and 105 amino acids in length. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12479"
] | [
"DUF3698"
] | [
31
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Debaryomyces"
] | [
31
] | 1 | [] | [] | 0 | true | Family | Protein of unknown function DUF3698 | Protein of unknown function DUF3698 | DUF3698 | 2 |
IPR022168 | 22,168 | Golgi associated RAB2 interactor protein-like, Rab2B-binding domain | GARIL-like_Rab2B-bd | Domain | 2,720 | false | false | This domain is found in Golgi-associated RAB2 interactor proteins and it is likely a Rab2B-binding domain [ , , ]. Some members included in this entry, such as GAR1A/B andGAR2, are RAB2B effector proteins required for accurate acrosome formation and normal male fertility [ , ]. GARIL5 is a Rab2B effector protein which ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12480"
] | [
"GARIL_Rab2_bd"
] | [
2720
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00100832",
"PUB00100833",
"PUB00100834",
"PUB00100835"
] | [
"26209634",
"29025071",
"34714330",
"28930687"
] | [
"Small GTPase Rab2B and Its Specific Binding Protein Golgi-associated Rab2B Interactor-like 4 (GARI-L4) Regulate Golgi Morphology.",
"The expression characteristics of FAM71D and its association with sperm motility.",
"FAM71F1 binds to RAB2A and RAB2B and is essential for acrosome formation and male fertility i... | [
2015,
2017,
2021,
2017
] | 4 | [] | [] | 0 | 0 | null | [
"Bilateria"
] | [
2720
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
34,
18,
37
] | 3 | true | Domain | Golgi associated RAB2 interactor protein-like, Rab2B-binding domain | Golgi associated RAB2 interactor protein-like, Rab2B-binding domain | GARIL-like_Rab2B-bd | 3 |
IPR022169 | 22,169 | Protein of unknown function DUF3701 | DUF3701 | Family | 1,152 | false | false | This domain family is found in bacteria, and is approximately 100 amino acids in length. The family is found in association with . | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12482"
] | [
"DUF3701"
] | [
1152
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Pseudomonadota",
"ecological metagenomes"
] | [
4,
1146,
2
] | 3 | [] | [] | 0 | true | Family | Protein of unknown function DUF3701 | Protein of unknown function DUF3701 | DUF3701 | 6 |
IPR022170 | 22,170 | E3 Ubiquitin ligase MUL1-like | MUL1-like | Domain | 4,589 | false | false | This domain is found in mitochondrial ubiquitin ligase activator of NFKB 1 (MULAN, also known as MUL1) from animals and ubiquitin E3 Ligase SP1/SP2/SPL1/SPL2 from Arabidopsis. MUL1 is a multifunctional E3 ubiquitin ligase anchored in the outer mitochondrial membrane with its RING finger domain facing the cytoplasm. Mul... | [
"GO:0004842",
"GO:0006996",
"GO:0016567"
] | [
"ubiquitin-protein transferase activity",
"organelle organization",
"protein ubiquitination"
] | [
"molecular_function",
"biological_process",
"biological_process"
] | 3 | [
"PFAM"
] | [
"PF12483"
] | [
"GIDE"
] | [
4589
] | 1 | [
"EC",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"2.3.2.27",
"PWY-7511",
"R-DME-5689880",
"R-DME-8951664",
"R-DME-9755511",
"R-HSA-5689880",
"R-HSA-8951664",
"R-HSA-9755511",
"R-MMU-5689880",
"R-MMU-8951664",
"R-MMU-9755511"
] | [
"EC:2.3.2.27",
"METACYC:PWY-7511",
"REACTOME:R-DME-5689880",
"REACTOME:R-DME-8951664",
"REACTOME:R-DME-9755511",
"REACTOME:R-HSA-5689880",
"REACTOME:R-HSA-8951664",
"REACTOME:R-HSA-9755511",
"REACTOME:R-MMU-5689880",
"REACTOME:R-MMU-8951664",
"REACTOME:R-MMU-9755511"
] | 11 | [] | 0 | [
"PUB00066812",
"PUB00066813",
"PUB00080689",
"PUB00080690",
"PUB00093921",
"PUB00093923"
] | [
"18591963",
"18207745",
"26387714",
"23118188",
"23399697",
"27034206"
] | [
"GIDE is a mitochondrial E3 ubiquitin ligase that induces apoptosis and slows growth.",
"Cargo-selected transport from the mitochondria to peroxisomes is mediated by vesicular carriers.",
"Regulation of Chloroplast Protein Import by the Ubiquitin E3 Ligase SP1 Is Important for Stress Tolerance in Plants.",
"C... | [
2008,
2008,
2015,
2012,
2013,
2016
] | 6 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"ecological metagenomes"
] | [
187,
731,
3655,
16
] | 4 | [
"Arabidopsis thaliana",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
28,
4,
1,
3,
1,
8,
4,
28
] | 8 | true | Domain | E3 Ubiquitin ligase MUL1-like | E3 Ubiquitin ligase MUL1-like | MUL1-like | 6 |
IPR022171 | 22,171 | PPE, C-terminal | PPE_C | Domain | 5,463 | false | false | This domain is found at the C-terminal of bacterial proteins from the PPE family, and is approximately 90 amino acids in length. The domain is found in association with . There is a conserved SVP sequence motif. There is a single completely conserved residue W that may be functionally important. The proteins in this fa... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12484"
] | [
"PPE-SVP"
] | [
5463
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00054031",
"PUB00054032",
"PUB00054033",
"PUB00103913",
"PUB00103914",
"PUB00103929",
"PUB00103930"
] | [
"19602151",
"18981138",
"18267304",
"32138343",
"32139546",
"25155747",
"25275011"
] | [
"Mycobacterial PE, PPE and ESX clusters: novel insights into the secretion of these most unusual protein families.",
"The ESX-5 secretion system of Mycobacterium marinum modulates the macrophage response.",
"Mycobacterial PE_PGRS proteins contain calcium-binding motifs with parallel beta-roll folds.",
"PPE51 ... | [
2009,
2008,
2007,
2020,
2020,
2014,
2014
] | 7 | [] | [] | 0 | 0 | null | [
"Mycobacteriaceae"
] | [
5463
] | 1 | [] | [] | 0 | true | Domain | PPE, C-terminal | PPE, C-terminal | PPE_C | 1 |
IPR022172 | 22,172 | Protein of unknown function DUF3703 | DUF3703 | Family | 1,310 | false | false | This family of proteins is found in bacteria. Proteins in this family are typically between 113 and 135 amino acids in length. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12487"
] | [
"DUF3703"
] | [
1310
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Rotaria sordida",
"ecological metagenomes"
] | [
1302,
1,
7
] | 3 | [] | [] | 0 | true | Family | Protein of unknown function DUF3703 | Protein of unknown function DUF3703 | DUF3703 | 3 |
IPR022174 | 22,174 | Nuclear receptor coactivator 4, N-terminal | NCOA4_N | Domain | 1,200 | false | false | This entry represents a region found towards the N-terminal of NCOA4 which according to structure predictions it may consist of a long helix combined with disordered segments. Nuclear receptor coactivator 4, also known as ARA70, is a coactivator for the androgen receptor (AR) [ ] and can function as a ligand-enhanced c... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12489"
] | [
"ARA70"
] | [
1200
] | 1 | [
"REACTOME"
] | [
"R-HSA-9841922"
] | [
"REACTOME:R-HSA-9841922"
] | 1 | [] | 0 | [
"PUB00090342",
"PUB00090345",
"PUB00090346",
"PUB00090347",
"PUB00154514"
] | [
"10347167",
"25327288",
"26436293",
"8643607",
"24910095"
] | [
"Identification of ARA70 as a ligand-enhanced coactivator for the peroxisome proliferator-activated receptor gamma.",
"Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo.",
"Ferritinophagy via NCOA4 is required for erythropoiesis and is ... | [
1999,
2014,
2015,
1996,
2014
] | 5 | [] | [] | 0 | 0 | null | [
"Eumetazoa"
] | [
1200
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
6,
11,
4
] | 4 | true | Domain | Nuclear receptor coactivator 4, N-terminal | Nuclear receptor coactivator 4, N-terminal | NCOA4_N | 5 |
IPR022175 | 22,175 | BCAS3 domain | BCAS3_dom | Domain | 4,443 | false | false | This domain is found towards the C-terminal of BCAS3 and ATG18-like proteins from plants. In BCAS3, this domain seems to be important for PHAF1 interactions [ ]. This entry includes BCAS3 microtubule associated cell migration factor (BCAS3) from animals and AT18F/G/H from Arabidopsis. BCAS3 is a microtubule associated ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12490"
] | [
"BCAS3"
] | [
4443
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00089259",
"PUB00097858",
"PUB00098125"
] | [
"17505058",
"33499712",
"15860012"
] | [
"Estrogen induces expression of BCAS3, a novel estrogen receptor-alpha coactivator, through proline-, glutamic acid-, and leucine-rich protein-1 (PELP1).",
"Mammalian BCAS3 and C16orf70 associate with the phagophore assembly site in response to selective and non-selective autophagy.",
"AtATG18a is required for ... | [
2007,
2021,
2005
] | 3 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
4443
] | 1 | [
"Arabidopsis thaliana",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
14,
9,
2,
4,
7,
8,
9,
29
] | 8 | true | Domain | BCAS3 domain | BCAS3 domain | BCAS3_dom | 5 |
IPR022176 | 22,176 | Apolipoprotein B100 C-terminal | ApoB100_C | Domain | 580 | false | false | This domain is found in the C terminus of some apolipoprotein B100 (ApoB100) proteins. It is approximately 60 amino acids in length and contains two conserved sequence motifs: QLS and LIDL. ApoB100 has an essential role in the assembly and secretion of triglyceride-rich lipoproteins and lipids transport [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12491"
] | [
"ApoB100_C"
] | [
580
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-HSA-202733",
"R-HSA-3000471",
"R-HSA-3000480",
"R-HSA-3000484",
"R-HSA-3000497",
"R-HSA-381426",
"R-HSA-432142",
"R-HSA-5686938",
"R-HSA-8856825",
"R-HSA-8856828",
"R-HSA-8866423",
"R-HSA-8957275",
"R-HSA-8963888",
"R-HSA-8963901",
"R-HSA-8964026",
"R-HSA-8964038",
"R-HSA-8964041"... | [
"REACTOME:R-HSA-202733",
"REACTOME:R-HSA-3000471",
"REACTOME:R-HSA-3000480",
"REACTOME:R-HSA-3000484",
"REACTOME:R-HSA-3000497",
"REACTOME:R-HSA-381426",
"REACTOME:R-HSA-432142",
"REACTOME:R-HSA-5686938",
"REACTOME:R-HSA-8856825",
"REACTOME:R-HSA-8856828",
"REACTOME:R-HSA-8866423",
"REACTOME:R... | 56 | [
"9bd1",
"9bd8",
"9bde",
"9bdt",
"9coo",
"9e9r",
"9ea7",
"9eag"
] | 8 | [
"PUB00056882"
] | [
"17934898"
] | [
"Cloning and tissue expression characterization of the chicken APOB gene."
] | [
2007
] | 1 | [] | [] | 0 | 0 | null | [
"Bilateria"
] | [
580
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
4,
2,
6
] | 3 | true | Domain | Apolipoprotein B100 C-terminal | Apolipoprotein B100 C-terminal | ApoB100_C | 2 |
IPR022179 | 22,179 | Cilia- and flagella-associated protein 276 | CFAP276 | Family | 934 | false | false | This family of proteins is found in eukaryotes. There is a single completely conserved residue D that may be functionally important. The family includes CFAP276 and homologues. Bovin CFAP276 has been identified as a microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axonem... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12494"
] | [
"DUF3695"
] | [
934
] | 1 | [] | [] | [] | 0 | [
"7rro",
"7ung",
"8i7o",
"8i7r",
"8iyj",
"8j07",
"8otz",
"8snb",
"8to0",
"9cpb",
"9cpc",
"9fqr"
] | 12 | [
"PUB00093604",
"PUB00100771"
] | [
"31199454",
"34715025"
] | [
"Mutations in C1orf194, encoding a calcium regulator, cause dominant Charcot-Marie-Tooth disease.",
"De novo identification of mammalian ciliary motility proteins using cryo-EM."
] | [
2019,
2021
] | 2 | [] | [] | 0 | 0 | null | [
"Metazoa"
] | [
934
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
1,
2,
1,
3
] | 5 | true | Family | Cilia- and flagella-associated protein 276 | Cilia- and flagella-associated protein 276 | CFAP276 | 2 |
IPR022180 | 22,180 | Vegetative insecticide protein 3 | Vip3 | Family | 170 | false | false | This entry includes Vip3A and related proteins, such as Vip3B and Vip3C. They are insecticidal proteins produced during the vegetative growth phase of B. thuringiensis. Vip3A contains a conserved N-terminal domain and a highly variable C-terminal region. After ingestion of the toxin by the larva, Vip3A is activated thr... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12495"
] | [
"Vip3A_N"
] | [
170
] | 1 | [] | [] | [] | 0 | [
"6tfj",
"6tfk",
"6v1v",
"6yrf",
"6yrg",
"7ntx",
"9efg",
"9efi"
] | 8 | [
"PUB00092847"
] | [
"26935135"
] | [
"Bacterial Vegetative Insecticidal Proteins (Vip) from Entomopathogenic Bacteria."
] | [
2016
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Hymenolepis diminuta"
] | [
169,
1
] | 2 | [] | [] | 0 | true | Family | Vegetative insecticide protein 3 | Vegetative insecticide protein 3 | Vip3 | 5 |
IPR022181 | 22,181 | Bcl2-/adenovirus E1B 19kDa-interacting protein 2 | Bcl2-/adenovirus-E1B | Family | 5,721 | false | false | This domain family is found in eukaryotes, and is typically between 119 and 133 amino acids in length. There is a conserved HGGY sequence motif. This family is Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2. It interacts with pro- and anti- apoptotic molecules in the cell. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12496"
] | [
"BNIP2"
] | [
5721
] | 1 | [
"REACTOME",
"REACTOME"
] | [
"R-HSA-525793",
"R-MMU-525793"
] | [
"REACTOME:R-HSA-525793",
"REACTOME:R-MMU-525793"
] | 2 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Metazoa"
] | [
5721
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
21,
2,
24,
15,
20
] | 5 | true | Family | Bcl2-/adenovirus E1B 19kDa-interacting protein 2 | Bcl2-/adenovirus E1B 19kDa-interacting protein 2 | Bcl2-/adenovirus-E1B | 6 |
IPR022182 | 22,182 | ABC transporter phosphate permease PstC, N-terminal domain | PstC_N | Domain | 2,945 | false | false | This domain is found the high-affinity inorganic phosphate transporter PstC from some bacterial species [ ]. It is found in association with . There is a single completely conserved residue P that may be functionally important. | [
"GO:0006817"
] | [
"phosphate ion transport"
] | [
"biological_process"
] | 1 | [
"PFAM"
] | [
"PF12501"
] | [
"DUF3708"
] | [
2945
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00062324"
] | [
"22520387"
] | [
"The Pst system of Streptococcus mutans is important for phosphate transport and adhesion to abiotic surfaces."
] | [
2012
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
2923,
4,
18
] | 3 | [] | [] | 0 | true | Domain | ABC transporter phosphate permease PstC, N-terminal domain | ABC transporter phosphate permease PstC, N-terminal domain | PstC_N | 2 |
IPR022183 | 22,183 | Protein of unknown function DUF3710 | DUF3710 | Family | 4,579 | false | false | This family of proteins is found in bacteria. Proteins in this family are typically between 237 and 284 amino acids in length. There are two conserved sequence motifs: DLG and DGPRW. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12502"
] | [
"DUF3710"
] | [
4579
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"metagenomes"
] | [
4522,
57
] | 2 | [] | [] | 0 | true | Family | Protein of unknown function DUF3710 | Protein of unknown function DUF3710 | DUF3710 | 3 |
IPR022184 | 22,184 | Cucumber mosaic virus 1a protein C-terminal | CMV_1a_C | Domain | 362 | false | false | This domain family is found in viruses, and is approximately 90 amino acids in length. It is found in association with , . and contains a conserved GLG sequence motif. 1a protein is the major virulence factor of the (Cucumber mosaic virus. The Ns strain of CMV causes necrotic lesions to Nicotiana spp. while other strai... | [
"GO:0008168",
"GO:0016817"
] | [
"methyltransferase activity",
"hydrolase activity, acting on acid anhydrides"
] | [
"molecular_function",
"molecular_function"
] | 2 | [
"PFAM"
] | [
"PF12503"
] | [
"CMV_1a_C"
] | [
362
] | 1 | [
"EC",
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"... | [
"2.1.1.-",
"3.6.4.-",
"PWY-1061",
"PWY-2083",
"PWY-3542",
"PWY-4021",
"PWY-4161",
"PWY-4202",
"PWY-5059",
"PWY-5105",
"PWY-5301",
"PWY-5305",
"PWY-5479",
"PWY-5665",
"PWY-5729",
"PWY-5748",
"PWY-5765",
"PWY-5773",
"PWY-5846",
"PWY-5883",
"PWY-5975",
"PWY-5987",
"PWY-601",... | [
"EC:2.1.1.-",
"EC:3.6.4.-",
"METACYC:PWY-1061",
"METACYC:PWY-2083",
"METACYC:PWY-3542",
"METACYC:PWY-4021",
"METACYC:PWY-4161",
"METACYC:PWY-4202",
"METACYC:PWY-5059",
"METACYC:PWY-5105",
"METACYC:PWY-5301",
"METACYC:PWY-5305",
"METACYC:PWY-5479",
"METACYC:PWY-5665",
"METACYC:PWY-5729",
... | 148 | [] | 0 | [
"PUB00053357"
] | [
"15305604"
] | [
"The necrotic pathotype of the cucumber mosaic virus (CMV) ns strain is solely determined by amino acid 461 of the 1a protein."
] | [
2004
] | 1 | [] | [] | 0 | 0 | null | [
"Glycine max",
"Riboviria"
] | [
1,
361
] | 2 | [] | [] | 0 | true | Domain | Cucumber mosaic virus 1a protein C-terminal | Cucumber mosaic virus 1a protein C-terminal | CMV_1a_C | 1 |
IPR022185 | 22,185 | Protein of unknown function DUF3712 | DUF3712 | Family | 3,438 | false | false | This domain family is found in Fungi, and is approximately 130 amino acids in length. This domain has a distant similarity to LEA-2 domain [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12505"
] | [
"DUF3712"
] | [
3438
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00100166"
] | [
"34347309"
] | [
"TMEM106B in humans and Vac7 and Tag1 in yeast are predicted to be lipid transfer proteins."
] | [
2022
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Microlunatus endophyticus"
] | [
3437,
1
] | 2 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)"
] | [
2
] | 1 | true | Family | Protein of unknown function DUF3712 | Protein of unknown function DUF3712 | DUF3712 | 1 |
IPR022187 | 22,187 | Conjugative transposon, TraM | Conjug_transposon_TraM | Family | 2,800 | false | false | Proteins in this entry are designated TraM and are found in a proposed transfer region of a class of conjugative transposon found in the Bacteroides lineage. | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"TIGR03779"
] | [
"Bac_Flav_CT_M"
] | [
2800
] | 1 | [
"GP"
] | [
"GenProp0858"
] | [
"GP:GenProp0858"
] | 1 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Pseudomonadati",
"metagenomes"
] | [
2765,
35
] | 2 | [] | [] | 0 | true | Family | Conjugative transposon, TraM | Conjugative transposon, TraM | Conjug_transposon_TraM | 4 |
IPR022188 | 22,188 | TASOR, DUF3715 | TASOR_DUF3715 | Domain | 3,168 | false | false | This domain is found in eukaryotes, and is approximately 170 amino acids in length. Proteins containing this domain include TASOR and TASOR 2 (also known as FAM208A/B) proteins [ ]. TASOR is a key component of the HUSH complex, a vertebrate-specific multiprotein complex that mediates epigenetic repression of both exoge... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12509"
] | [
"DUF3715"
] | [
3168
] | 1 | [
"REACTOME"
] | [
"R-HSA-9843970"
] | [
"REACTOME:R-HSA-9843970"
] | 1 | [
"6tl1"
] | 1 | [
"PUB00087337",
"PUB00100823",
"PUB00100824",
"PUB00100825",
"PUB00100826",
"PUB00100827"
] | [
"26022416",
"28581500",
"30487602",
"29211708",
"33009411",
"28839193"
] | [
"GENE SILENCING. Epigenetic silencing by the HUSH complex mediates position-effect variegation in human cells.",
"Hyperactivation of HUSH complex function by Charcot-Marie-Tooth disease mutation in MORC2.",
"NP220 mediates silencing of unintegrated retroviral DNA.",
"Selective silencing of euchromatic L1s rev... | [
2015,
2017,
2018,
2018,
2020,
2017
] | 6 | [] | [] | 0 | 0 | null | [
"Eumetazoa"
] | [
3168
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
11,
11,
6,
9
] | 4 | true | Domain | TASOR, DUF3715 | TASOR, DUF3715 | TASOR_DUF3715 | 1 |
IPR022189 | 22,189 | Smoothelin | SMTN | Domain | 3,123 | false | false | This entry represents a domain found in the smoothelin protein, which is a smooth muscle-specific cytoskeletal protein exclusively found in differentiated smooth muscle cells [ ]. This domain is found in association with the calponin homology domain ( ). | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12510"
] | [
"Smoothelin"
] | [
3123
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00071318"
] | [
"19950405"
] | [
"Smoothelin is a specific marker for smooth muscle neoplasms of the gastrointestinal tract."
] | [
2009
] | 1 | [] | [] | 0 | 0 | null | [
"Metazoa"
] | [
3123
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
21,
18,
24,
6,
7
] | 5 | true | Domain | Smoothelin | Smoothelin | SMTN | 1 |
IPR022190 | 22,190 | Protein of unknown function DUF3716 | DUF3716 | Family | 2,830 | false | false | This domain family is found in eukaryotes, and is approximately 60 amino acids in length. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12511"
] | [
"DUF3716"
] | [
2830
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
2830
] | 1 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)"
] | [
9
] | 1 | true | Family | Protein of unknown function DUF3716 | Protein of unknown function DUF3716 | DUF3716 | 9 |
IPR022192 | 22,192 | ATP-dependent RNA helicase SUV3, C-terminal domain | SUV3_C | Domain | 6,231 | false | false | This domain is found in ATP-dependent RNA helicase SUV3. It is found in bacterial and eukaryotic proteins, it is approximately 50 amino acids in length and it is usually found in association with . The yeast mitochondrial degradosome (mtEXO) is an NTP-dependent exoribonuclease involved in mitochondrial RNA metabolism. ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12513"
] | [
"SUV3_C"
] | [
6231
] | 1 | [
"EC",
"REACTOME"
] | [
"3.6.4.13",
"R-HSA-9836573"
] | [
"EC:3.6.4.13",
"REACTOME:R-HSA-9836573"
] | 2 | [
"3rc3",
"3rc8",
"6f4a",
"7w1r"
] | 4 | [
"PUB00056881"
] | [
"12426313"
] | [
"The yeast mitochondrial degradosome. Its composition, interplay between RNA helicase and RNase activities and the role in mitochondrial RNA metabolism."
] | [
2003
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"ecological metagenomes"
] | [
1029,
5181,
21
] | 3 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
9,
1,
1,
1,
2,
1,
1,
2,
3,
1,
1,
22
] | 12 | true | Domain | ATP-dependent RNA helicase SUV3, C-terminal domain | ATP-dependent RNA helicase SUV3, C-terminal domain | SUV3_C | 7 |
IPR022193 | 22,193 | Protein of unknown function DUF3718 | DUF3718 | Family | 1,037 | false | false | This domain family is found in bacteria, and is approximately 70 amino acids in length. There is a single completely conserved residue C that may be functionally important. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12514"
] | [
"DUF3718"
] | [
1037
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Austropuccinia psidii MF-1",
"Bacteria",
"ecological metagenomes"
] | [
1,
1033,
3
] | 3 | [] | [] | 0 | true | Family | Protein of unknown function DUF3718 | Protein of unknown function DUF3718 | DUF3718 | 3 |
IPR022194 | 22,194 | Domain of unknown function DUF3719 | DUF3719 | Domain | 2,554 | false | false | This domain is found in eukaryotes, and is approximately 70 amino acids in length. There is a conserved HLR sequence motif. There are two completely conserved residues (W and H) that may be functionally important. This domain is present in proteins such as primary cilium assembly protein FAM149B1. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12516"
] | [
"DUF3719"
] | [
2554
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
2554
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
7,
13,
8,
12
] | 5 | true | Domain | Domain of unknown function DUF3719 | Domain of unknown function DUF3719 | DUF3719 | 1 |
IPR022195 | 22,195 | Protein of unknown function DUF3720 | DUF3720 | Family | 251 | false | false | This entry represents a family of uncharacterised proteins found in Trypanosoma. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12517"
] | [
"DUF3720"
] | [
251
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Trypanosoma cruzi"
] | [
251
] | 1 | [] | [] | 0 | true | Family | Protein of unknown function DUF3720 | Protein of unknown function DUF3720 | DUF3720 | 5 |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.