LiteFold/InterPro · Datasets at Hugging Face

IPR025620

25,620

YlaH-like protein

YlaH

Family

1,381

false

The YlaH-like protein family includes the B. subtilis YlaH protein , which is functionally uncharacterised.There is a conserved LGFA sequence motif.

[]

0

[ "PFAM" ]

[ "PF14036" ]

[ "YlaH" ]

[ 1381 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria" ]

[ 1381 ]

1

[]

0

true

Family

YlaH-like protein

YlaH

5

IPR025621

25,621

YoqO-like protein

YoqO

Family

344

false

The YoqO-like protein family includes the B. subtilis YoqO protein , which is functionally uncharacterised. There are two completely conserved residues (I and Y) that may be functionally important.

[]

0

[ "PFAM" ]

[ "PF14037" ]

[ "YoqO" ]

[ 344 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacillus phage SPbeta", "Bacteria" ]

[ 1, 343 ]

2

[]

0

true

Family

YoqO-like protein

YoqO

9

IPR025622

25,622

Forespore factor SpoIIIL

SpoIIIL

Family

1,135

false

This entry represents forespore factor SpoIIIL and related proteins. SpoIIIL acts as a forespore-specific factor that contributes to the cell-cell signalling pathway leading to sigma K activation in the mother cell [ ]. It is required for efficient accumulation of peptidoglycan precursors at intermediate stages of deve...

[]

0

[ "PFAM" ]

[ "PF14038" ]

[ "YqzE" ]

[ 1135 ]

1

[]

0

[]

0

[ "PUB00057382", "PUB00162567", "PUB00163279" ]

[ "18628959", "26735940", "40609071" ]

[ "Genome holography: deciphering function-form motifs from gene expression data.", "High-Throughput Genetic Screens Identify a Large and Diverse Collection of New Sporulation Genes in Bacillus subtilis.", "SpoIIIL is a forespore factor required for efficient cell-cell signalling during Bacillus subtilis sporulat...

[ 2008, 2016, 2025 ]

3

[]

0

null

[ "Bacillales", "Phytophthora kernoviae 00238/432" ]

[ 1134, 1 ]

2

[]

0

true

Family

Forespore factor SpoIIIL

SpoIIIL

2

IPR025623

25,623

YusW-like protein

YusW

Family

866

false

The YusW-like protein family includes the B. subtilis YusW protein , which is functionally uncharacterised.

[]

0

[ "PFAM" ]

[ "PF14039" ]

[ "YusW" ]

[ 866 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacillota" ]

[ 866 ]

1

[]

0

true

Family

YusW-like protein

YusW

4

IPR025624

25,624

PcfK-like protein

PcfK

Family

1,297

false

The PcfK-like protein family includes the Enterococcus faecalis PcfK protein , which is functionally uncharacterised. There are two completely conserved residues (D and L) that may be functionally important.

[]

0

[ "PFAM" ]

[ "PF14058" ]

[ "PcfK" ]

[ 1297 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Caudoviricetes", "metagenomes" ]

[ 1265, 17, 15 ]

3

[]

0

true

Family

PcfK-like protein

PcfK

3

IPR025625

25,625

YuzL-like protein

YuzL

Family

769

false

The YuzL-like protein family, which is functionally uncharacterised, includes the B. subtilis YuzL protein .

[]

0

[ "PFAM" ]

[ "PF14115" ]

[ "YuzL" ]

[ 769 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacillales" ]

[ 769 ]

1

[]

0

true

Family

YuzL-like protein

YuzL

2

IPR025626

25,626

YyzF-like protein

YyzF

Family

1,269

false

The YyzF-like protein family, which is functionally uncharacterised, includes the B. subtilis YyzF protein .

[]

0

[ "PFAM", "NCBIFAM" ]

[ "PF14116", "TIGR04129" ]

[ "YyzF", "CxxH_BA5709" ]

[ 1269, 1269 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Rhizophagus irregularis" ]

[ 1268, 1 ]

2

[]

0

true

Family

YyzF-like protein

YyzF

1

IPR025629

25,629

Protein of unknown function DUF4287

DUF4287

Family

4,622

false

The function of these proteins is not known.

[]

0

[ "PFAM" ]

[ "PF14117" ]

[ "DUF4287" ]

[ 4622 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Knufia peltigerae", "ecological metagenomes", "miscellaneous Crenarchaeota group-1 archaeon SG8-32-1" ]

[ 4453, 1, 167, 1 ]

4

[]

0

true

Family

Protein of unknown function DUF4287

DUF4287

3

IPR025630

25,630

Protein of unknown function DUF4288

DUF4288

Family

849

false

The function of these proteins is not known.

[]

0

[ "PFAM" ]

[ "PF14119" ]

[ "DUF4288" ]

[ 849 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "ecological metagenomes" ]

[ 847, 2 ]

2

[]

0

true

Family

Protein of unknown function DUF4288

DUF4288

1

IPR025631

25,631

Putative porin-10

Porin_10

Family

2,692

false

This family of membrane β-barrel proteins is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are typically between 655 and 722 amino acids in length. is identified by Gene3D as a membrane bound β-barrel. These sequences are putative porins.

[]

0

[ "PFAM" ]

[ "PF14121" ]

[ "Porin_10" ]

[ 2692 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Eukaryota", "Pseudomonadati", "unclassified sequences" ]

[ 2, 2620, 70 ]

3

[]

0

true

Family

Putative porin-10

Porin_10

8

IPR025632

25,632

Protein of unknown function DUF4290

DUF4290

Family

2,455

false

This family of proteins is functionally uncharacterised. There are two conserved sequence motifs: EYGR and KLWD.

[]

0

[ "PFAM" ]

[ "PF14123" ]

[ "DUF4290" ]

[ 2455 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Elysia marginata", "unclassified sequences" ]

[ 2402, 1, 52 ]

3

[]

0

true

Family

Protein of unknown function DUF4290

DUF4290

7

IPR025633

25,633

Protein of unknown function DUF4291

DUF4291

Family

3,205

false

This family of proteins is functionally uncharacterised. There are two conserved sequence motifs: VYQAY and RMTW.

[]

0

[ "PFAM", "PANTHER" ]

[ "PF14124", "PTHR38567" ]

[ "DUF4291", "" ]

[ 3205, 3133 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "hydrothermal vent metagenome", "unclassified Klosneuvirinae" ]

[ 2304, 897, 2, 2 ]

4

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)" ]

[ 1 ]

1

true

Family

Protein of unknown function DUF4291

DUF4291

9

IPR025634

25,634

Protein of unknown function DUF4292

DUF4292

Family

2,658

false

The function of these proteins is not known.

[]

0

[ "PFAM" ]

[ "PF14125" ]

[ "DUF4292" ]

[ 2658 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 2605, 5, 48 ]

3

[]

0

true

Family

Protein of unknown function DUF4292

DUF4292

2

IPR025635

25,635

Protein of unknown function DUF4293

DUF4293

Family

2,498

false

The function of these proteins is not known.

[]

0

[ "PFAM" ]

[ "PF14126" ]

[ "DUF4293" ]

[ 2498 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "metagenomes" ]

[ 2456, 42 ]

2

[]

0

true

Family

Protein of unknown function DUF4293

DUF4293

6

IPR025637

25,637

Domain of unknown function DUF4333

DUF4333

Domain

2,846

false

This domain is functionally uncharacterised. There are two completely conserved C residues that may be functionally important.

[]

0

[ "PFAM" ]

[ "PF14230" ]

[ "DUF4333" ]

[ 2846 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "ecological metagenomes" ]

[ 2829, 17 ]

2

[]

0

true

Domain

Domain of unknown function DUF4333

DUF4333

8

IPR025638

25,638

Protein of unknown function DUF4336

DUF4336

Family

5,158

false

The function of these proteins is not known.

[]

0

[ "PFAM", "PANTHER" ]

[ "PF14234", "PTHR33835" ]

[ "DUF4336", "" ]

[ 4276, 5058 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Halobacteriales", "ecological metagenomes" ]

[ 1920, 3196, 27, 15 ]

4

[ "Arabidopsis thaliana", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 8, 1, 3, 7 ]

4

true

Family

Protein of unknown function DUF4336

DUF4336

7

IPR025639

25,639

Druantia protein DruA

DruA

Family

1,053

false

Druantia type I is an antiviral defense system composed of DruA, DruB, DruC, DruD and DruE. Expression of Druantia in E.coli (strain MG1655) confers resistance to phage lambda, SECphi18, SECphi27 and T4. This entry represents DruA [ ].

[]

0

[ "PFAM" ]

[ "PF14236" ]

[ "DruA" ]

[ 1053 ]

1

[]

0

[]

0

[ "PUB00097806" ]

[ "29371424" ]

[ "Systematic discovery of antiphage defense systems in the microbial pangenome." ]

[ 2018 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "metagenomes" ]

[ 15, 848, 36, 12, 142 ]

5

[]

0

true

Family

Druantia protein DruA

DruA

9

IPR025640

25,640

GYF domain 2

GYF_2

Domain

10,323

false

This domain is found in bacteria, archaea and eukaryotes, and is approximately 50 amino acids in length. It contains an evolutionary conserved signature W-X-Y-X6-11-GPF-X4-M-X2-W-X3-GYF, the site of interaction with proline-rich peptides. Proteins containing this domain include RME-8 (Required for receptor-mediated end...

[]

0

[ "PFAM" ]

[ "PF14237" ]

[ "GYF_2" ]

[ 10323 ]

1

[ "REACTOME" ]

[ "R-HSA-6798695" ]

[ "REACTOME:R-HSA-6798695" ]

1

[ "7vcf", "7xzi", "7z3c", "8z9y" ]

4

[ "PUB00085381", "PUB00091010", "PUB00091011", "PUB00091012" ]

[ "20937886", "24643499", "28125316", "27733515" ]

[ "SET DOMAIN GROUP2 is the major histone H3 lysine [corrected] 4 trimethyltransferase in Arabidopsis.", "RME-8 coordinates the activity of the WASH complex with the function of the retromer SNX dimer to control endosomal tubulation.", "Protein import-independent functions of Tic56, a component of the 1-MDa trans...

[ 2010, 2014, 2017, 2016 ]

4

[]

0

null

[ "Bacteria", "Eukaryota", "Methanobacteriota", "metagenomes", "unclassified Caudoviricetes" ]

[ 5873, 4336, 8, 104, 2 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 18, 2, 14, 3, 2, 3, 10, 5, 55 ]

9

true

Domain

GYF domain 2

GYF_2

5

IPR025641

25,641

Domain of unknown function DUF4340

DUF4340

Domain

3,318

false

This domain is found in a group of uncharacterised bacterial proteins. Its function is not yet known.

[]

0

[ "PFAM" ]

[ "PF14238" ]

[ "DUF4340" ]

[ 3318 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences", "uncultured marine group II/III euryarchaeote AD1000_29_E08" ]

[ 3148, 4, 165, 1 ]

4

[]

0

true

Domain

Domain of unknown function DUF4340

DUF4340

6

IPR025642

25,642

Domain of unknown function DUF4342

DUF4342

Domain

1,493

false

This function of this domain is not known. There is a single completely conserved residue P that may be functionally important.

[]

0

[ "PFAM" ]

[ "PF14242" ]

[ "DUF4342" ]

[ 1493 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria", "ecological metagenomes" ]

[ 10, 1428, 55 ]

3

[]

0

true

Domain

Domain of unknown function DUF4342

DUF4342

1

IPR025643

25,643

ATP-grasp domain, R2K clade family 3

R2K_3

Domain

1,444

false

Proteins containing this domain are a group of ATP-grasp enzymes belonging to the R2K clade, wherein one of the absolutely-conserved lysine residues has migrated to the RAGYNA domain which is a part of the core ATP-grasp module. This family is predicted to catalyse peptide ligation reactions on protein substrates in bi...

[]

0

[ "PFAM" ]

[ "PF14243" ]

[ "R2K_3" ]

[ 1444 ]

1

[]

0

[]

0

[ "PUB00091030" ]

[ "25976611" ]

[ "The eukaryotic translation initiation regulator CDC123 defines a divergent clade of ATP-grasp enzymes with a predicted role in novel protein modifications." ]

[ 2015 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "metagenomes" ]

[ 3, 1398, 18, 11, 14 ]

5

[]

0

true

Domain

ATP-grasp domain, R2K clade family 3

R2K_3

5

IPR025645

25,645

Domain of unknown function DUF4349

DUF4349

Domain

7,419

false

This domain is functionally uncharacterised. There is a single completely conserved residue D that may be functionally important.

[]

0

[ "PFAM" ]

[ "PF14257" ]

[ "DUF4349" ]

[ 7419 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "metagenomes" ]

[ 197, 7077, 46, 99 ]

4

[]

0

true

Domain

Domain of unknown function DUF4349

DUF4349

9

IPR025647

25,647

Putative component of 'biosynthetic module'

YceG_bac

Domain

787

false

This is a domain found 2-3 times in the YceG family of bacterial proteins. YceG is an additional gene-product encoded in the Ter operon and might thus be part of a 'biosynthetic module' encoding certain enzymes [ ].

[]

0

[ "PFAM" ]

[ "PF14266" ]

[ "YceG_bac" ]

[ 787 ]

1

[]

0

[]

0

[ "PUB00066658" ]

[ "23044854" ]

[ "Ter-dependent stress response systems: novel pathways related to metal sensing, production of a nucleoside-like metabolite, and DNA-processing." ]

[ 2012 ]

1

[]

0

null

[ "Bacteria", "Smittium simulii", "bioreactor metagenome" ]

[ 785, 1, 1 ]

3

[]

0

true

Domain

Putative component of 'biosynthetic module'

YceG_bac

1

IPR025648

25,648

Protein of unknown function DUF4358

DUF4358

Family

1,201

false

The function of these proteins is not known.

[]

0

[ "PFAM" ]

[ "PF14270" ]

[ "DUF4358" ]

[ 1201 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacillota", "metagenomes" ]

[ 1187, 14 ]

2

[]

0

true

Family

Protein of unknown function DUF4358

DUF4358

2

IPR025649

25,649

Protein of unknown function DUF4360

DUF4360

Family

4,434

false

This family of proteins is functionally uncharacterised. There is a conserved GCP sequence motif near the N terminus.

[]

0

[ "PFAM", "PANTHER" ]

[ "PF14273", "PTHR38847" ]

[ "DUF4360", "" ]

[ 4429, 4015 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Tetraselmis virus 1" ]

[ 2127, 2306, 1 ]

3

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)" ]

[ 3 ]

1

true

Family

Protein of unknown function DUF4360

DUF4360

1

IPR025650

25,650

Alkyldihydroxyacetonephosphate synthase

Alkyl-DHAP_Synthase

Family

8,147

false

Alkyl-dihydroxyacetonephosphate synthase is a peroxisomal enzyme that plays a key role in the biosynthesis of ether phospholipids [ ].

[ "GO:0008609", "GO:0008610" ]

[ "alkylglycerone-phosphate synthase activity", "lipid biosynthetic process" ]

[ "molecular_function", "biological_process" ]

2

[ "PANTHER" ]

[ "PTHR46568" ]

[ "" ]

[ 8147 ]

1

[ "EC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "2.5.1.26", "PWY-7782", "R-CEL-75896", "R-DME-75896", "R-DME-9033241", "R-HSA-75896", "R-HSA-9033241", "R-HSA-9033500", "R-MMU-75896", "R-MMU-9033241", "R-RNO-75896", "R-RNO-9033241" ]

[ "EC:2.5.1.26", "METACYC:PWY-7782", "REACTOME:R-CEL-75896", "REACTOME:R-DME-75896", "REACTOME:R-DME-9033241", "REACTOME:R-HSA-75896", "REACTOME:R-HSA-9033241", "REACTOME:R-HSA-9033500", "REACTOME:R-MMU-75896", "REACTOME:R-MMU-9033241", "REACTOME:R-RNO-75896", "REACTOME:R-RNO-9033241" ]

12

[ "2uuu", "2uuv", "4bby", "4bc7", "4bc9", "4bca", "5adz", "5ae1", "5ae2", "5ae3", "6gou" ]

11

[ "PUB00057405" ]

[ "9553082" ]

[ "Alkyl-dihydroxyacetonephosphate synthase. Fate in peroxisome biogenesis disorders and identification of the point mutation underlying a single enzyme deficiency." ]

[ 1998 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Sym plasmid", "Yasminevirus sp. GU-2018", "metagenomes" ]

[ 67, 4670, 3262, 1, 1, 146 ]

6

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 1, 2, 1, 16, 7, 6 ]

7

true

Family

Alkyldihydroxyacetonephosphate synthase

Alkyl-DHAP_Synthase

6

IPR025652

25,652

Acyl-CoA thioesterase 2, C-terminal domain

TesB_C

Domain

14,242

false

Escherichia coli thioesterase 2 (TesB) adopts a 'double hot dog' configuration. It shows two structural repeats connected by a long loop. There is, however, no sequence similarity between the two halves of the molecule. This entry represents the C-terminal pseudo-domain, which is structurally similar to the recently de...

[]

0

[ "PFAM" ]

[ "PF02551" ]

[ "Acyl_CoA_thio" ]

[ 14242 ]

1

[ "EC", "METACYC", "METACYC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "3.1.2.20", "PWY-5148", "PWY-735", "PWY-7913", "R-SCE-193368", "R-SCE-2046106", "R-SCE-389887", "R-SCE-390247", "R-SCE-9033241" ]

[ "EC:3.1.2.20", "METACYC:PWY-5148", "METACYC:PWY-735", "METACYC:PWY-7913", "REACTOME:R-SCE-193368", "REACTOME:R-SCE-2046106", "REACTOME:R-SCE-389887", "REACTOME:R-SCE-390247", "REACTOME:R-SCE-9033241" ]

9

[ "1c8u", "3rd7", "3u0a", "4qfw", "4r4u", "4r9z" ]

6

[ "PUB00015864" ]

[ "10876240" ]

[ "Crystal structure of the Escherichia coli thioesterase II, a homolog of the human Nef binding enzyme." ]

[ 2000 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 12387, 1714, 141 ]

3

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)" ]

[ 5, 1, 2, 1, 2, 1, 1 ]

7

true

Domain

Acyl-CoA thioesterase 2, C-terminal domain

TesB_C

1

IPR025655

25,655

Peroxisomal membrane protein 14

PEX14

Family

6,050

false

Peroxisomal membrane protein PEX14, or peroxin-14, is a core component of the peroxisomal translocation machinery or importomer [ , ]. PEX14 is involved in the docking of PEX5-bound protein onto the peroxisomal membrane, and it may be involved in the translocation step into the peroxisome matrix [ ]. In addition to its...

[ "GO:0005515", "GO:0016560", "GO:0005778" ]

[ "protein binding", "protein import into peroxisome matrix, docking", "peroxisomal membrane" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PANTHER" ]

[ "PTHR23058" ]

[ "" ]

[ 6050 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-DDI-8866654", "R-DDI-9033241", "R-DDI-9603798", "R-HSA-8866654", "R-HSA-9033241", "R-HSA-9603798", "R-MMU-8866654", "R-MMU-9033241", "R-MMU-9603798", "R-RNO-8866654", "R-RNO-9033241", "R-RNO-9603798", "R-SCE-8866654", "R-SCE-9033241", "R-SCE-9603798", "R-SPO-8866654", "R-SPO-90332...

[ "REACTOME:R-DDI-8866654", "REACTOME:R-DDI-9033241", "REACTOME:R-DDI-9603798", "REACTOME:R-HSA-8866654", "REACTOME:R-HSA-9033241", "REACTOME:R-HSA-9603798", "REACTOME:R-MMU-8866654", "REACTOME:R-MMU-9033241", "REACTOME:R-MMU-9603798", "REACTOME:R-RNO-8866654", "REACTOME:R-RNO-9033241", "REACTOM...

18

[ "2w84", "2w85", "3ff5", "4bxu", "5aon", "5l87", "5l8a", "5mmc", "5n8v", "5oml", "6rt2", "6s6r", "6s7m", "6s9y", "6spt", "6zfw", "7qrc", "8gi0", "8rib" ]

19

[ "PUB00050069", "PUB00055948", "PUB00057430", "PUB00068179" ]

[ "19197237", "10704444", "11863372", "17046076" ]

[ "Structural basis for competitive interactions of Pex14 with the import receptors Pex5 and Pex19.", "PEX19 binds multiple peroxisomal membrane proteins, is predominantly cytoplasmic, and is required for peroxisome membrane synthesis.", "NAPP2, a peroxisomal membrane protein, is also a transcriptional corepresso...

[ 2009, 2000, 2002, 2006 ]

4

[]

0

null

[ "Eukaryota" ]

[ 6050 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 4, 1, 5, 1, 3, 3, 2, 8, 7, 1, 1, 65 ]

12

true

Family

Peroxisomal membrane protein 14

PEX14

2

IPR025657

25,657

RadC-like JAB domain

RadC_JAB

Domain

29,263

false

This domain is found in a family of proteins present widely across bacteria. This family was named initially with reference to the Escherichia coli radC102 mutation which suggested that RadC was involved in repair of DNA lesions [ ]. However, the relevant mutation has subsequently been shown to be in recG, where radC i...

[]

0

[ "PFAM", "CDD" ]

[ "PF04002", "cd08071" ]

[ "RadC", "MPN_DUF2466" ]

[ 29263, 26683 ]

2

[]

0

[ "2qlc" ]

1

[ "PUB00009802", "PUB00044698", "PUB00044699", "PUB00057473" ]

[ "10224240", "11053371", "18556794", "21890906" ]

[ "Tandem repeat recombination induced by replication fork defects in Escherichia coli requires a novel factor, RadC.", "radC102 of Escherichia coli is an allele of recG.", "RadC, a misleading name?", "Evolution of the deaminase fold and multiple origins of eukaryotic editing and mutagenic nucleic acid deaminas...

[ 1999, 2000, 2008, 2011 ]

4

[ "IPR037518" ]

[]

1

0

1

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 149, 28547, 84, 32, 451 ]

5

[ "Escherichia coli (strain K12)" ]

[ 4 ]

1

true

Domain

RadC-like JAB domain

RadC_JAB

9

IPR025659

25,659

Tubby-like, C-terminal

Tubby-like_C

Homologous_superfamily

36,913

false

Tubby, an autosomal recessive mutation, mapping to mouse chromosome 7, was recently found to be the result of a splicing defect in a novel gene with unknown function. This mutation maps to the tub gene [ , ]. The mouse tubby mutation is the cause of maturity-onset obesity, insulin resistance and sensory deficits. By co...

[]

0

[ "CATHGENE3D", "SSF" ]

[ "G3DSA:3.20.90.10", "SSF54518" ]

[ "", "" ]

[ 15192, 36864 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-CEL-5610787", "R-HSA-5610787", "R-HSA-8951664", "R-MMU-5610787", "R-MMU-8951664" ]

[ "REACTOME:R-CEL-5610787", "REACTOME:R-HSA-5610787", "REACTOME:R-HSA-8951664", "REACTOME:R-MMU-5610787", "REACTOME:R-MMU-8951664" ]

5

[ "1c8z", "1i7e", "1s31", "1zxu", "2fim", "2q4m", "3c5n", "8fh3" ]

8

[ "PUB00000932", "PUB00004232", "PUB00007281", "PUB00014197" ]

[ "8612280", "8606774", "10591637", "14708010" ]

[ "Identification and characterization of the mouse obesity gene tubby: a member of a novel gene family.", "A candidate gene for the mouse mutation tubby.", "Implication of tubby proteins as transcription factors by structure-based functional analysis.", "Tubby proteins: the plot thickens." ]

[ 1996, 1996, 1999, 2004 ]

4

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "metagenomes" ]

[ 316, 5082, 31457, 58 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)", "Zea mays" ]

[ 135, 9, 41, 9, 23, 23, 103, 25, 1, 183 ]

10

true

Homologous_superfamily

Tubby-like, C-terminal

Tubby-like_C

5

IPR025660

25,660

Cysteine peptidase, histidine active site

Pept_his_AS

Active_site

50,786

false

The sequences around the three active site residues are well conserved. This entry represents the histidine active site. The catalytic triad consists of this entry, and . This catalytic triad detects mainly proteases of the C1 family, including papain and several cathepsins. Thiol (cysteine) proteases (EC 3.4.22.-) [ ]...

[]

0

[ "PROSITE" ]

[ "PS00639" ]

[ "THIOL_PROTEASE_HIS" ]

[ 50786 ]

1

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", ...

[ "3.4.22", "R-BTA-1442490", "R-BTA-1474228", "R-BTA-1592389", "R-BTA-1679131", "R-BTA-2132295", "R-BTA-5683826", "R-BTA-6798695", "R-BTA-8939242", "R-CEL-1474228", "R-CEL-1592389", "R-CEL-2132295", "R-CEL-6798695", "R-CEL-8939242", "R-CFA-1474228", "R-CFA-1592389", "R-CFA-1679131", ...

[ "EC:3.4.22", "REACTOME:R-BTA-1442490", "REACTOME:R-BTA-1474228", "REACTOME:R-BTA-1592389", "REACTOME:R-BTA-1679131", "REACTOME:R-BTA-2132295", "REACTOME:R-BTA-5683826", "REACTOME:R-BTA-6798695", "REACTOME:R-BTA-8939242", "REACTOME:R-CEL-1474228", "REACTOME:R-CEL-1592389", "REACTOME:R-CEL-21322...

86

[ "1a6r", "1aec", "1aim", "1atk", "1au0", "1au2", "1au3", "1au4", "1ayu", "1ayv", "1ayw", "1bgo", "1bp4", "1bqi", "1by8", "1cjl", "1cpj", "1cqd", "1cs8", "1csb", "1cte", "1cv8", "1cvz", "1ewl", "1ewm", "1ewo", "1ewp", "1f29", "1f2a", "1f2b", "1f2c", "1fh0"...

487

[ "PUB00000685", "PUB00011704", "PUB00057831", "PUB00057832" ]

[ "3148320", "11517925", "17408887", "18497895" ]

[ "Sequence homologies, hydrophobic profiles and secondary structures of cathepsins B, H and L: comparison with papain and actinidin.", "Evolutionary lines of cysteine peptidases.", "Silicateins, the major biosilica forming enzymes present in demosponges: protein analysis and phylogenetic relationship.", "Biofa...

[ 1988, 2001, 2007, 2008 ]

4

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "metagenomes" ]

[ 179, 4085, 46153, 206, 163 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Zea mays" ]

[ 112, 19, 46, 12, 88, 70, 86, 66, 1, 158 ]

10

true

Active_site

Cysteine peptidase, histidine active site

Pept_his_AS

4

IPR025661

25,661

Cysteine peptidase, asparagine active site

Pept_asp_AS

Active_site

40,488

false

The sequences around the three active site residues are well conserved. This entry represents the asparagine active site. The catalytic triad consists of this entry, and . This catalytic triad detects mainly proteases of the C1 family, including papain and several cathepsins. Thiol (cysteine) proteases (EC 3.4.22.-) [ ...

[]

0

[ "PROSITE" ]

[ "PS00640" ]

[ "THIOL_PROTEASE_ASN" ]

[ 40488 ]

1

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", ...

[ "3.4.22", "R-BTA-1442490", "R-BTA-1474228", "R-BTA-1592389", "R-BTA-1679131", "R-BTA-2022377", "R-BTA-204005", "R-BTA-2132295", "R-BTA-432720", "R-BTA-5683826", "R-BTA-5694530", "R-BTA-6798695", "R-BTA-8939242", "R-CEL-1474228", "R-CEL-1592389", "R-CEL-2022377", "R-CEL-204005", "R-...

[ "EC:3.4.22", "REACTOME:R-BTA-1442490", "REACTOME:R-BTA-1474228", "REACTOME:R-BTA-1592389", "REACTOME:R-BTA-1679131", "REACTOME:R-BTA-2022377", "REACTOME:R-BTA-204005", "REACTOME:R-BTA-2132295", "REACTOME:R-BTA-432720", "REACTOME:R-BTA-5683826", "REACTOME:R-BTA-5694530", "REACTOME:R-BTA-6798695...

99

[ "1aec", "1aim", "1atk", "1au0", "1au2", "1au3", "1au4", "1ayu", "1ayv", "1ayw", "1bgo", "1bp4", "1bqi", "1by8", "1cjl", "1cpj", "1cs8", "1csb", "1cte", "1cvz", "1deu", "1ef7", "1ewl", "1ewm", "1ewo", "1ewp", "1f29", "1f2a", "1f2b", "1f2c", "1fh0", "1gec"...

463

[ "PUB00000685", "PUB00011704", "PUB00057831", "PUB00057832" ]

[ "3148320", "11517925", "17408887", "18497895" ]

[ "Sequence homologies, hydrophobic profiles and secondary structures of cathepsins B, H and L: comparison with papain and actinidin.", "Evolutionary lines of cysteine peptidases.", "Silicateins, the major biosilica forming enzymes present in demosponges: protein analysis and phylogenetic relationship.", "Biofa...

[ 1988, 2001, 2007, 2008 ]

4

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "metagenomes" ]

[ 19, 204, 40069, 129, 67 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 106, 16, 42, 11, 63, 52, 99, 51, 144 ]

9

true

Active_site

Cysteine peptidase, asparagine active site

Pept_asp_AS

8

IPR025662

25,662

Sigma-54 interaction domain, ATP-binding site 1

Sigma_54_int_dom_ATP-bd_1

Binding_site

124,509

false

This entry represents a conserved site corresponding to the first ATP-binding motif located in the N-terminal section of the sigma-54 interaction domain. Some bacterial regulatory proteins activate the expression of genes from promoters recognised by core RNA polymerase associated with the alternative sigma-54 factor. ...

[]

0

[ "PROSITE" ]

[ "PS00675" ]

[ "SIGMA54_INTERACT_1" ]

[ 124509 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-CEL-6798695", "R-CEL-6811436", "R-CEL-8873719", "R-CEL-8876198", "R-DRE-6798695", "R-DRE-8873719", "R-GGA-6798695", "R-GGA-6811436", "R-GGA-8876198", "R-HSA-6798695", "R-HSA-6811436", "R-HSA-8873719", "R-HSA-8876198", "R-MMU-6798695", "R-MMU-6811436", "R-MMU-8873719", "R-MMU-88761...

[ "REACTOME:R-CEL-6798695", "REACTOME:R-CEL-6811436", "REACTOME:R-CEL-8873719", "REACTOME:R-CEL-8876198", "REACTOME:R-DRE-6798695", "REACTOME:R-DRE-8873719", "REACTOME:R-GGA-6798695", "REACTOME:R-GGA-6811436", "REACTOME:R-GGA-8876198", "REACTOME:R-HSA-6798695", "REACTOME:R-HSA-6811436", "REACTOM...

21

[ "1ny5", "1ny6", "1ojl", "1x3s", "2gza", "3cbq", "3dzd", "3m0e", "3q85", "4aii", "4bs1", "4bt0", "4bt1", "4l4u", "4loa", "4ly6", "4lzz", "5exp", "5exs", "5ext", "5exx", "5jcs", "5yoz", "6hyp", "6i26", "6i27", "6iy8", "6j7e", "6jdi", "6jdl", "6l6o", "6ylf"...

48

[ "PUB00000103", "PUB00001221", "PUB00002228", "PUB00004389" ]

[ "2694934", "1534752", "8407777", "2041769" ]

[ "Prokaryotic signal transduction mediated by sensor and regulator protein pairs.", "The prokaryotic enhancer binding protein NTRC has an ATPase activity which is phosphorylation and DNA dependent.", "The sigma 54 bacterial enhancer-binding protein family: mechanism of action and phylogenetic relationship of the...

[ 1989, 1992, 1993, 1991 ]

4

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 302, 110228, 12494, 121, 1364 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus",...

[ 22, 2, 39, 4, 10, 17, 8, 3, 6, 9, 1, 1, 6 ]

13

true

Binding_site

Sigma-54 interaction domain, ATP-binding site 1

Sigma_54_int_dom_ATP-bd_1

5

IPR025663

25,663

A-kinase anchor protein 28kDa

AKAP_28

Family

1,197

false

28kDa AKAP (AKAP28) is highly enriched in human airway axonemes. The mRNA for AKAP28 is up-regulated as primary airway cells differentiate and is specifically expressed in tissues containing cilia and/or flagella [ ]. Homologs of AKAP28 are present in all animals.

[]

0

[ "PFAM" ]

[ "PF14469" ]

[ "AKAP28" ]

[ 1197 ]

1

[]

0

[ "9d2f", "9fqr" ]

2

[ "PUB00057855" ]

[ "12475942" ]

[ "Characterization of an A-kinase anchoring protein in human ciliary axonemes." ]

[ 2002 ]

1

[]

0

null

[ "Eukaryota" ]

[ 1197 ]

1

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 2, 1, 1, 3 ]

5

true

Family

A-kinase anchor protein 28kDa

AKAP_28

4

IPR025664

25,664

Stage III sporulation protein AC/AD family

Spore_III_AC/AD

Family

4,833

false

This family consists of several bacterial stage III sporulation protein AC (SpoIIIAC) and SpoIIIAD sequences. The exact function of this family is unknown. SpoIIIAD is an uncharacterised protein which is part of the spoIIIA operon that acts at sporulation stage III as part of a cascade of events leading to endospore fo...

[]

0

[ "PFAM" ]

[ "PF06686" ]

[ "SpoIIIAC" ]

[ 4833 ]

1

[]

0

[]

0

[ "PUB00020362" ]

[ "8969508" ]

[ "Systematic sequencing of the 283 kb 210 degrees-232 degrees region of the Bacillus subtilis genome containing the skin element and many sporulation genes." ]

[ 1996 ]

1

[]

[ "IPR009570", "IPR014211" ]

0

2

0

[ "Bacteria", "Phytophthora kernoviae 00238/432", "metagenomes" ]

[ 4794, 1, 38 ]

3

[]

0

true

Family

Stage III sporulation protein AC/AD family

Spore_III_AC/AD

7

IPR025665

25,665

Outer membrane protein, beta-barrel domain 2

Beta-barrel_OMP_2

Domain

21,674

false

This domain is found in a wide range of outer membrane proteins. This domain assumes a membrane bound β-barrel fold. It is part of a Pfam clan that includes other outer membrane protein β-barrel domains.

[]

0

[ "PFAM" ]

[ "PF13568" ]

[ "OMP_b-brl_2" ]

[ 21674 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 21399, 11, 264 ]

3

[]

0

true

Domain

Outer membrane protein, beta-barrel domain 2

Beta-barrel_OMP_2

5

IPR025667

25,667

SprB repeat

SprB_repeat

Repeat

4,674

false

This repeat occurs several times in SprB, a cell surface protein involved in gliding motility in the bacterium Flavobacterium johnsoniae [ ].

[]

0

[ "PFAM" ]

[ "PF13573" ]

[ "SprB" ]

[ 4674 ]

1

[]

0

[]

0

[ "PUB00066706" ]

[ "18281397" ]

[ "SprB is a cell surface component of the Flavobacterium johnsoniae gliding motility machinery." ]

[ 2008 ]

1

[]

0

null

[ "Bacteria", "Candidatus Marsarchaeota G2 archaeon BE_D", "Eukaryota", "Viruses", "metagenomes" ]

[ 4570, 1, 8, 20, 75 ]

5

[]

0

true

Repeat

SprB repeat

SprB_repeat

6

IPR025668

25,668

Transposase DDE domain

Tnp_DDE_dom

Domain

37,388

false

Transposase proteins are necessary for efficient DNA transposition. This domain is a member of the DDE superfamily, which contains three carboxylate residues that are believed to be responsible for coordinating metal ions needed for catalysis. The catalytic activity of this enzyme involves DNA cleavage at a specific si...

[]

0

[ "PFAM", "PFAM", "PFAM", "PFAM", "PFAM" ]

[ "PF13586", "PF13612", "PF13701", "PF13737", "PF13751" ]

[ "DDE_Tnp_1_2", "DDE_Tnp_1_3", "DDE_Tnp_1_4", "DDE_Tnp_1_5", "DDE_Tnp_1_6" ]

[ 5268, 5455, 8264, 5429, 13013 ]

5

[]

0

[]

0

[ "PUB00001489" ]

[ "8335077" ]

[ "Identification and analysis of the gas vesicle gene cluster on an unstable plasmid of Halobacterium halobium." ]

[ 1993 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 226, 36319, 86, 12, 745 ]

5

[]

0

true

Domain

Transposase DDE domain

Tnp_DDE_dom

5

IPR025669

25,669

AAA domain

AAA_dom

Domain

97,110

false

This entry represents a wide variety of AAA domains, including some that have lost essential nucleotide binding residues in the P-loop.

[]

0

[ "PFAM" ]

[ "PF13614" ]

[ "AAA_31" ]

[ 97110 ]

1

[]

0

[ "1g3q", "1g3r", "1ion", "1wcv", "2bej", "2bek", "2oze", "2ved", "3bfv", "3cio", "3ez2", "3ez6", "3ez7", "3ez9", "3ezf", "3k9g", "3k9h", "3la6", "3pg5", "4jlv", "4jmp", "4pfs", "5if9", "5ihp", "5k5z", "5tvk", "5u1j", "6iub", "6iuc", "6iud", "6non", "6noo"...

57

[]

0

[]

[ "IPR005702" ]

0

1

0

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "plasmids", "unclassified sequences" ]

[ 2018, 93004, 286, 81, 23, 1698 ]

6

[ "Escherichia coli (strain K12)" ]

[ 3 ]

1

true

Domain

AAA domain

AAA_dom

9

IPR025670

25,670

Fox-1 C-terminal domain

Fox-1_C_dom

Domain

7,709

false

This domain is found in the C-terminal section of Fox-1 and its homologues, which regulate alternative splicing events by binding to 5'-UGCAUGU-3' elements [ , ].

[]

0

[ "PFAM" ]

[ "PF12414" ]

[ "Fox-1_C" ]

[ 7709 ]

1

[ "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-6803529", "R-HSA-9022707", "R-HSA-9768919" ]

[ "REACTOME:R-HSA-6803529", "REACTOME:R-HSA-9022707", "REACTOME:R-HSA-9768919" ]

3

[]

0

[ "PUB00057858", "PUB00057859" ]

[ "16537540", "15824060" ]

[ "Fox-2 splicing factor binds to a conserved intron motif to promote inclusion of protein 4.1R alternative exon 16.", "Tissue-dependent isoforms of mammalian Fox-1 homologs are associated with tissue-specific splicing activities." ]

[ 2006, 2005 ]

2

[]

0

null

[ "Vertebrata" ]

[ 7709 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 144, 38, 15, 25 ]

4

true

Domain

Fox-1 C-terminal domain

Fox-1_C_dom

7

IPR025672

25,672

Sigma factor regulator C-terminal domain

Sigma_reg_C_dom

Domain

1,928

false

This entry represents a domain found in the C-terminal region of a number of sigma factor regulator proteins. It may represent a sensory domain [ ].

[]

0

[ "PFAM" ]

[ "PF13791" ]

[ "Sigma_reg_C" ]

[ 1928 ]

1

[]

0

[]

0

[ "PUB00046113" ]

[ "14993308" ]

[ "Interaction of Bacillus subtilis extracytoplasmic function (ECF) sigma factors with the N-terminal regions of their potential anti-sigma factors." ]

[ 2004 ]

1

[]

0

null

[ "Bacteria", "metagenomes" ]

[ 1926, 2 ]

2

[]

0

true

Domain

Sigma factor regulator C-terminal domain

Sigma_reg_C_dom

7

IPR025673

25,673

Protein of unknown function with PCYCGC motif

PCYCGC

Family

1,153

false

These proteins contain a PCYCGC motif and four other conserved cysteines. Their function is unknown.

[]

0

[ "PFAM" ]

[ "PF13798" ]

[ "PCYCGC" ]

[ 1153 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria", "ecological metagenomes" ]

[ 8, 1124, 21 ]

3

[]

0

true

Family

Protein of unknown function with PCYCGC motif

PCYCGC

4

IPR025674

25,674

Immunity protein Imm6

Imm6

Family

366

false

This entry represents a predicted immunity protein, with an α+β fold (mostly α helices). The protein is present in polymorphic toxin systems as an immediate gene neighbour of the toxin gene [ ].

[]

0

[ "PFAM" ]

[ "PF14434" ]

[ "Imm6" ]

[ 366 ]

1

[]

0

[]

0

[ "PUB00057473" ]

[ "21890906" ]

[ "Evolution of the deaminase fold and multiple origins of eukaryotic editing and mutagenic nucleic acid deaminases from bacterial toxin systems." ]

[ 2011 ]

1

[]

0

null

[ "Anaeromyces robustus", "Bacteria" ]

[ 1, 365 ]

2

[]

0

true

Family

Immunity protein Imm6

Imm6

8

IPR025675

25,675

Immunity protein Imm5

Imm5

Domain

243

false

This entry represents a domain found in a predicted immunity protein, with an all-α fold, present in bacterial polymorphic toxin systems as an immediate neighbour of the toxin [ ].

[]

0

[ "PFAM" ]

[ "PF14423" ]

[ "Imm5" ]

[ 243 ]

1

[]

0

[ "7jtu" ]

1

[ "PUB00057473" ]

[ "21890906" ]

[ "Evolution of the deaminase fold and multiple origins of eukaryotic editing and mutagenic nucleic acid deaminases from bacterial toxin systems." ]

[ 2011 ]

1

[]

0

null

[ "Bacteria", "Halobacteriales", "Purpureocillium takamizusanense" ]

[ 238, 4, 1 ]

3

[]

0

true

Domain

Immunity protein Imm5

Imm5

8

IPR025676

25,676

Clr5 domain

Clr5_dom

Domain

8,689

false

This domain is found at the N terminus of the Clr5 protein, which has been shown to be involved in silencing in fission yeast. This domain has been found to often be associated with proteins that contain ankyrin repeats and large regions of disordered sequence [ ].

[]

0

[ "PFAM" ]

[ "PF14420" ]

[ "Clr5" ]

[ 8689 ]

1

[]

0

[]

0

[ "PUB00057863" ]

[ "21253571" ]

[ "H3K9me-independent gene silencing in fission yeast heterochromatin by Clr5 and histone deacetylases." ]

[ 2011 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "uncultured Caudovirales phage" ]

[ 5, 8683, 1 ]

3

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 10, 1 ]

2

true

Domain

Clr5 domain

Clr5_dom

6

IPR025677

25,677

OST-HTH associated domain

OST-HTH-assoc_dom

Domain

1,601

false

This domain often occurs in association with the OST-HTH domain, which is predicted to be involved in RNA-binding [ ].

[]

0

[ "PFAM" ]

[ "PF14418" ]

[ "OHA" ]

[ 1601 ]

1

[]

0

[]

0

[ "PUB00057373" ]

[ "20302647" ]

[ "OST-HTH: a novel predicted RNA-binding domain." ]

[ 2010 ]

1

[]

0

null

[ "Eukaryota" ]

[ 1601 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 15, 2, 4 ]

3

true

Domain

OST-HTH associated domain

OST-HTH-assoc_dom

5

IPR025678

25,678

Immunity protein Imm3

Imm3

Family

229

false

This entry represents a predicted immunity protein, with a mostly all-alpha fold, present in bacterial polymorphic toxin systems as an immediate gene neighbour of the toxin gene [ ].

[]

0

[ "PFAM" ]

[ "PF14425" ]

[ "Imm3" ]

[ 229 ]

1

[]

0

[]

0

[ "PUB00057473" ]

[ "21890906" ]

[ "Evolution of the deaminase fold and multiple origins of eukaryotic editing and mutagenic nucleic acid deaminases from bacterial toxin systems." ]

[ 2011 ]

1

[]

0

null

[ "Bacteria" ]

[ 229 ]

1

[]

0

true

Family

Immunity protein Imm3

Imm3

4

IPR025679

25,679

Immunity protein Imm2

Imm2

Family

34

false

This entry represents a predicted immunity protein, with a mostly all-alpha fold, present in bacterial polymorphic toxin systems as an immediate gene neighbour of the toxin gene [ ].

[]

0

[ "PFAM" ]

[ "PF14426" ]

[ "Imm2" ]

[ 34 ]

1

[]

0

[]

0

[ "PUB00057473" ]

[ "21890906" ]

[ "Evolution of the deaminase fold and multiple origins of eukaryotic editing and mutagenic nucleic acid deaminases from bacterial toxin systems." ]

[ 2011 ]

1

[]

0

null

[ "Pseudomonadota" ]

[ 34 ]

1

[]

0

true

Family

Immunity protein Imm2

Imm2

7

IPR025680

25,680

Double-stranded DNA deaminase immunity protein DddI

DddI

Family

1,269

false

DddI is an immunity protein component of a toxin-immunity protein module, which functions as a cellular contact-dependent growth inhibition (CDI) system [ ].

[]

0

[ "PFAM" ]

[ "PF14430" ]

[ "Imm1" ]

[ 1269 ]

1

[]

0

[ "6u08" ]

1

[ "PUB00097193" ]

[ "32641830" ]

[ "A bacterial cytidine deaminase toxin enables CRISPR-free mitochondrial base editing." ]

[ 2020 ]

1

[]

0

null

[ "Bacteria", "Parascaris univalens" ]

[ 1268, 1 ]

2

[]

0

true

Family

Double-stranded DNA deaminase immunity protein DddI

DddI

1

IPR025681

25,681

Phage phiEco32-like COOH-NH2 ligase-type 2

COOH-NH2_lig

Family

666

false

This entry represents a family of COOH-NH2 ligases/GCS superfamily found in the neighbourhood of YheC/D-like ATP-grasp and the CotE family of proteins in the firmicutes. Contextual analysis suggests that it might be involved in cell wall modification and spore coat biosynthesis [ ].

[]

0

[ "PFAM" ]

[ "PF14395" ]

[ "COOH-NH2_lig" ]

[ 666 ]

1

[]

0

[]

0

[ "PUB00057486" ]

[ "20023723" ]

[ "Amidoligases with ATP-grasp, glutamine synthetase-like and acetyltransferase-like domains: synthesis of novel metabolites and peptide modifications of proteins." ]

[ 2009 ]

1

[]

0

null

[ "Bacteria", "Viruses", "metagenomes" ]

[ 561, 76, 29 ]

3

[]

0

true

Family

Phage phiEco32-like COOH-NH2 ligase-type 2

COOH-NH2_lig

3

IPR025682

25,682

CpXC domain

CpXC_dom

Domain

712

false

This presumed domain is functionally uncharacterised. This domain is found mainly in bacterial proteins, and is typically between 122 and 134 amino acids in length. It contains four conserved cysteines forming two CpXC motifs.

[]

0

[ "PFAM" ]

[ "PF14353" ]

[ "CpXC" ]

[ 712 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 17, 680, 2, 13 ]

4

[]

0

true

Domain

CpXC domain

CpXC_dom

1

IPR025683

25,683

Protein beta

Protein_beta

Family

1,400

false

This family includes protein beta from Bacteriophage T4 ( ). Protein beta prevents the gop protein ( ) from killing the bacterial host cell [ ].

[]

0

[ "PFAM" ]

[ "PF14350" ]

[ "Beta_protein" ]

[ 1400 ]

1

[]

0

[]

0

[ "PUB00057864" ]

[ "2403440" ]

[ "Nonessential region of bacteriophage P4: DNA sequence, transcription, gene products, and functions." ]

[ 1990 ]

1

[]

0

null

[ "Bacteria", "Fungi", "Viruses", "metagenomes" ]

[ 1383, 3, 5, 9 ]

4

[]

0

true

Family

Protein beta

Protein_beta

5

IPR025684

25,684

Gliding motility protein SprA N-terminal domain

SprA_N_dom

Domain

2,431

false

This domain is found repeated three times in the N-terminal half of the gliding motility-related SprA proteins. The role of this domain in motility is uncertain [ ]. It is also found in proteins required for secretion [ ].

[]

0

[ "PFAM" ]

[ "PF14349" ]

[ "SprA_N" ]

[ 2431 ]

1

[]

0

[ "6h3i", "6h3j", "8gl6", "8gl8", "8glj", "8glk", "8glm", "8gln" ]

8

[ "PUB00057865", "PUB00057866" ]

[ "17644580", "17579257" ]

[ "Flavobacterium johnsoniae SprA is a cell surface protein involved in gliding motility.", "Identification of a Porphyromonas gingivalis novel protein sov required for the secretion of gingipains." ]

[ 2007, 2007 ]

2

[]

0

null

[ "Bacteria", "Eumetazoa", "metagenomes" ]

[ 2377, 4, 50 ]

3

[]

0

true

Domain

Gliding motility protein SprA N-terminal domain

SprA_N_dom

9

IPR025685

25,685

YoaP-like domain

YoaP-like_dom

Domain

1,256

false

The YoaP-like domain is found at the C terminus of the Bacillus subtilis YoaP protein ( ) and other bacterial and archaeal proteins, and is approximately 40 amino acids in length. There is a single completely conserved residue A that may be functionally important.

[]

0

[ "PFAM" ]

[ "PF14268" ]

[ "YoaP" ]

[ 1256 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria", "metagenomes" ]

[ 39, 1181, 36 ]

3

[]

0

true

Domain

YoaP-like domain

YoaP-like_dom

4

IPR025687

25,687

C4-type zinc-finger of DNA polymerase delta

Znf-C4pol

Domain

8,260

false

In fission yeast, this zinc-finger domain appears is the region of Pol3 that binds directly to the B-subunit, Cdc1 [ ]. Pol delta is a hetero-tetrameric enzyme comprising four evolutionarily well-conserved proteins: the catalytic subunit Pol3 and three smaller subunits Cdc1, Cdc27 and Cdm1 [ ].

[]

0

[ "PFAM" ]

[ "PF14260" ]

[ "zf-C4pol" ]

[ 8260 ]

1

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", ...

[ "2.7.7.7", "R-CEL-110314", "R-CEL-5651801", "R-CEL-5656169", "R-CEL-5696397", "R-CEL-5696400", "R-CEL-6782135", "R-CEL-6782210", "R-CEL-69091", "R-CEL-69166", "R-CEL-69183", "R-DDI-110314", "R-DDI-5651801", "R-DDI-5656169", "R-DDI-5696397", "R-DDI-6782135", "R-DDI-6782210", "R-DDI-...

[ "EC:2.7.7.7", "REACTOME:R-CEL-110314", "REACTOME:R-CEL-5651801", "REACTOME:R-CEL-5656169", "REACTOME:R-CEL-5696397", "REACTOME:R-CEL-5696400", "REACTOME:R-CEL-6782135", "REACTOME:R-CEL-6782210", "REACTOME:R-CEL-69091", "REACTOME:R-CEL-69166", "REACTOME:R-CEL-69183", "REACTOME:R-DDI-110314", ...

104

[ "6p1h", "6s1m", "6s1n", "6s1o", "6tny", "6tnz", "6v8p", "6v93", "7kc0", "7lxd", "7s0t", "8tlq", "8tlt", "9ekb" ]

14

[ "PUB00057868", "PUB00057869" ]

[ "1960723", "19686603" ]

[ "Characterization of the POL3 gene product from Schizosaccharomyces pombe indicates inter-species conservation of the catalytic subunit of DNA polymerase delta.", "Functional mapping of the fission yeast DNA polymerase delta B-subunit Cdc1 by site-directed and random pentapeptide insertion mutagenesis." ]

[ 1991, 2009 ]

2

[]

0

null

[ "Clandestinovirus", "Eukaryota" ]

[ 1, 8259 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 13, 1, 4, 2, 8, 7, 2, 3, 8, 2, 2, 17 ]

12

true

Domain

C4-type zinc-finger of DNA polymerase delta

Znf-C4pol

2

IPR025688

25,688

PGDYG protein

PGDYG_prot

Family

436

false

This family of proteins is functionally uncharacterised. Proteins in this family are approximately 150 amino acids in length. There is a conserved PGDYG motif.

[]

0

[ "PFAM" ]

[ "PF14083" ]

[ "PGDYG" ]

[ 436 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Florenciella parvula", "Natrinema thermotolerans", "Viruses", "ecological metagenomes" ]

[ 428, 1, 1, 2, 4 ]

5

[]

0

true

Family

PGDYG protein

PGDYG_prot

7

IPR025689

25,689

Sporulation protein YtrH

Spore_YtrH

Family

1,372

false

This family of proteins is involved in sporulation. It may contribute to the formation and stability of the thick peptidoglycan layer between the two membranes of the spore, known as the cortex [ ]. In Bacillus subtilis its expression is regulated by sigma-E [ ].

[]

0

[ "PFAM" ]

[ "PF14034" ]

[ "Spore_YtrH" ]

[ 1372 ]

1

[]

0

[]

0

[ "PUB00012907", "PUB00034546" ]

[ "12662922", "15547282" ]

[ "The sigmaE regulon and the identification of additional sporulation genes in Bacillus subtilis.", "Unmasking novel sporulation genes in Bacillus subtilis." ]

[ 2003, 2004 ]

2

[]

0

null

[ "Bacillota", "Phytophthora kernoviae 00238/432", "ecological metagenomes" ]

[ 1369, 1, 2 ]

3

[]

0

true

Family

Sporulation protein YtrH

Spore_YtrH

3

IPR025690

25,690

Methyltransferase, putative

Methyltransf_put

Family

726

false

The structure of the proteins in this family suggest that they might function as methyltransferases.

[]

0

[ "PFAM" ]

[ "PF12692" ]

[ "Methyltransf_17" ]

[ 726 ]

1

[]

0

[ "3iht" ]

1

[]

0

[]

0

null

[ "Alphaproteobacteria", "Effrenium voratum", "ecological metagenomes" ]

[ 720, 1, 5 ]

3

[]

0

true

Family

Methyltransferase, putative

Methyltransf_put

9

IPR025691

25,691

GspL periplasmic domain

GspL_pp_dom

Domain

4,458

false

This domain is the periplasmic domain of the GspL/EpsL family proteins. These proteins are involved in type II secretion systems.

[]

0

[ "PFAM" ]

[ "PF12693" ]

[ "GspL_C" ]

[ 4458 ]

1

[]

0

[ "2w7v", "5hl8", "5n7l", "6ghu", "8a9w", "8ab1" ]

6

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 4373, 8, 77 ]

3

[ "Escherichia coli (strain K12)" ]

[ 2 ]

1

true

Domain

GspL periplasmic domain

GspL_pp_dom

2

IPR025692

25,692

Mechanosensitive ion channel inner membrane domain 1

MscS_IM_dom1

Domain

5,566

false

The small mechanosensitive channel, MscS, is a part of the turgor-driven solute efflux system that protects bacteria from lysis in the event of osmotic shock [ ]. The MscS protein alone is sufficient to form a functional mechanosensitive channel gated directly by tension in the lipid bilayer. The MscS proteins are hept...

[]

0

[ "PFAM" ]

[ "PF12794" ]

[ "MscS_TM" ]

[ 5566 ]

1

[]

0

[ "7uw5", "7ux1" ]

2

[ "PUB00056121", "PUB00056122" ]

[ "12080120", "16079835" ]

[ "Purification of the small mechanosensitive channel of Escherichia coli (MscS): the subunit structure, conduction, and gating characteristics in liposomes.", "A possible unifying principle for mechanosensation." ]

[ 2002, 2005 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 5546, 9, 11 ]

3

[ "Escherichia coli (strain K12)" ]

[ 2 ]

1

true

Domain

Mechanosensitive ion channel inner membrane domain 1

MscS_IM_dom1

7

IPR025693

25,693

Glycine-zipper-containing OmpA-like membrane domain

Gly-zipper_OmpA-like_dom

Domain

745

false

This entry represents a glycine-zipper-containing OmpA-like membrane domain. The domain is found in a number of experimentally uncharacterised transmembrane proteins.

[]

0

[ "PFAM" ]

[ "PF13436" ]

[ "Gly-zipper_OmpA" ]

[ 745 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "ecological metagenomes" ]

[ 652, 88, 5 ]

3

[]

0

true

Domain

Glycine-zipper-containing OmpA-like membrane domain

Gly-zipper_OmpA-like_dom

4

IPR025694

25,694

Mitochondrial splicing apparatus component MNE1

MNE1

Family

130

false

MNE1 is a novel component of the mitochondrial splicing apparatus responsible for the processing of a COX1 group I intron in yeast [ ]. Yeast cells lacking MNE1 are deficient in intron splicing in the gene encoding the Cox1 subunit of cytochrome oxidase but do contain wild-type levels of the bc1 complex.

[ "GO:0000372", "GO:1990904" ]

[ "Group I intron splicing", "ribonucleoprotein complex" ]

[ "biological_process", "cellular_component" ]

2

[ "PFAM" ]

[ "PF13762" ]

[ "MNE1" ]

[ 130 ]

1

[]

0

[]

0

[ "PUB00057870" ]

[ "21257754" ]

[ "Mne1 is a novel component of the mitochondrial splicing apparatus responsible for processing of a COX1 group I intron in yeast." ]

[ 2011 ]

1

[]

0

null

[ "Eukaryota" ]

[ 130 ]

1

[ "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)" ]

[ 1 ]

1

true

Family

Mitochondrial splicing apparatus component MNE1

MNE1

3

IPR025695

25,695

DoxX-like family

DoxX-like

Family

2,712

false

This family of uncharacterised proteins appear to be related to DoxD ( ).

[]

0

[ "PFAM" ]

[ "PF13781" ]

[ "DoxX_3" ]

[ 2712 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Halobacteriales", "Protostomia", "metagenomes" ]

[ 2664, 26, 2, 20 ]

4

[]

0

true

Family

DoxX-like family

DoxX-like

6

IPR025696

25,696

Exosome RNA helicase MTR4-like, beta-barrel domain

Beta-barrel_MTR4

Domain

9,313

false

This entry represents the β-barrel of MTR4 and related Ski2-like helicases. Ski2 from yeast has an overall similar structure to MTR4 proteins. However, it does not have the KOW motif [ ] and it is not included in this entry. This entry also includes Circadian oscillator component FRH. Exosome RNA helicase Mtr4 is a ess...

[]

0

[ "PFAM" ]

[ "PF13234" ]

[ "MTR4_beta-barrel" ]

[ 9313 ]

1

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "3.6.4", "R-CEL-6791226", "R-CEL-72163", "R-CEL-9930044", "R-HSA-390471", "R-HSA-429958", "R-HSA-6791226", "R-HSA-72163", "R-HSA-9843970", "R-HSA-9930044", "R-MMU-429958", "R-MMU-6791226", "R-MMU-72163", "R-MMU-9930044", "R-SCE-6791226", "R-SPO-429958", "R-SPO-6791226", "R-SPO-7216...

[ "EC:3.6.4", "REACTOME:R-CEL-6791226", "REACTOME:R-CEL-72163", "REACTOME:R-CEL-9930044", "REACTOME:R-HSA-390471", "REACTOME:R-HSA-429958", "REACTOME:R-HSA-6791226", "REACTOME:R-HSA-72163", "REACTOME:R-HSA-9843970", "REACTOME:R-HSA-9930044", "REACTOME:R-MMU-429958", "REACTOME:R-MMU-6791226", "...

18

[ "2xgj", "4qu4", "4u4c", "4xgt", "5dzr", "5e02", "5ooq", "6bb8", "6d6q", "6d6r", "6fsz", "6ft6", "6ieg", "6ieh", "6lqs", "6ro1", "6yfv", "6ygu", "7ajt", "7aju", "7d4i", "7qdr", "7qds", "7qdy", "7qdz", "7qe0", "7s7b", "7s7c", "7z4y", "7z4z", "7z52", "9g8m"...

36

[ "PUB00057873", "PUB00058447", "PUB00129868", "PUB00151589" ]

[ "20512111", "22114319", "20566885", "27340124" ]

[ "The crystal structure of Mtr4 reveals a novel arch domain required for rRNA processing.", "The crystal structure of S. cerevisiae Ski2, a DExH helicase associated with the cytoplasmic functions of the exosome.", "Structural analysis reveals the characteristic features of Mtr4, a DExH helicase involved in nucle...

[ 2010, 2012, 2010, 2016 ]

4

[]

0

null

[ "Eukaryota" ]

[ 9313 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 14, 1, 4, 3, 24, 9, 2, 7, 10, 1, 3, 36 ]

12

true

Domain

Exosome RNA helicase MTR4-like, beta-barrel domain

Beta-barrel_MTR4

6

IPR025697

25,697

CLU domain

CLU_dom

Domain

8,454

false

The CLU domain (CLUstered mitochondria) is a eukaryotic domain found in highly conserved eukaryotic proteins required for correct mitochondrial dispersal [ , ]. The exact function of the domain is unknown [ ].

[]

0

[ "PFAM", "PROFILE" ]

[ "PF13236", "PS51823" ]

[ "CLU", "CLU" ]

[ 6146, 8391 ]

2

[]

0

[]

0

[ "PUB00057874", "PUB00057875", "PUB00057876" ]

[ "20457612", "9207087", "12952081" ]

[ "Two novel Src homology 2 domain proteins interact to regulate dictyostelium gene expression during growth and early development.", "The cluA- mutant of Dictyostelium identifies a novel class of proteins required for dispersion of mitochondria.", "Mitochondrial membrane dynamics are altered in cluA- mutants of ...

[ 2010, 1997, 2002 ]

3

[]

0

null

[ "Eukaryota" ]

[ 8454 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 25, 2, 10, 2, 4, 3, 1, 12, 4, 1, 1, 115 ]

12

true

Domain

CLU domain

CLU_dom

4

IPR025698

25,698

2TM domain

2TM_dom

Domain

7,162

false

This domain is comprised of two transmembrane α helices that are found associated with a wide range of other domains. This domain may be involved in cell lysis or peptidoglycan turnover.

[]

0

[ "PFAM" ]

[ "PF13239" ]

[ "2TM" ]

[ 7162 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 119, 6931, 10, 102 ]

4

[]

0

true

Domain

2TM domain

2TM_dom

4

IPR025699

25,699

ABC-2 membrane transporter-like

ABC2_memb-like

Family

5,663

false

This family is related to the ABC-2 membrane transporter family [ ].

[]

0

[ "PFAM" ]

[ "PF13346" ]

[ "ABC2_membrane_5" ]

[ 5663 ]

1

[]

0

[]

0

[ "PUB00004998" ]

[ "1303751" ]

[ "A new subfamily of bacterial ABC-type transport systems catalyzing export of drugs and carbohydrates." ]

[ 1992 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 31, 5587, 3, 42 ]

4

[]

0

true

Family

ABC-2 membrane transporter-like

ABC2_memb-like

5

IPR025700

25,700

L-lysine 6-monooxygenase/L-ornithine 5-monooxygenase

Lys/Orn_oxygenase

Family

13,106

false

This is a family of Rossmann fold oxidoreductases that catalyse NADPH-dependent hydroxylation and are involved in siderophore biosynthesis. This family includes L-ornithine 5-monooxygenase, which catalyses the hydroxylation of L-ornithine at the N5 position [ , ], and L-lysine 6-monooxygenase, which catalyses the hydro...

[]

0

[ "PFAM", "PANTHER" ]

[ "PF13434", "PTHR42802" ]

[ "Lys_Orn_oxgnase", "" ]

[ 13066, 10741 ]

2

[ "EC" ]

[ "1.14.13" ]

[ "EC:1.14.13" ]

1

[ "3s5w", "3s61", "4b63", "4b64", "4b65", "4b66", "4b67", "4b68", "4b69", "4d7e", "4nzh", "4tlx", "4tlz", "4tm0", "4tm1", "4tm3", "4tm4", "5cku", "5cqf", "5o8p", "5o8r", "6x0h", "6x0i", "6x0j", "6x0k", "6xbb", "6xbc", "7jvk", "7jvl", "7us3", "9nns" ]

31

[ "PUB00057881", "PUB00057882", "PUB00097965", "PUB00154953" ]

[ "8106324", "16461464", "16233371", "27541336" ]

[ "Cloning and nucleotide sequence of the pvdA gene encoding the pyoverdin biosynthetic enzyme L-ornithine N5-oxygenase in Pseudomonas aeruginosa.", "A genetic locus required for iron acquisition in Mycobacterium tuberculosis.", "dffA gene from Aspergillus oryzae encodes L-ornithine N5-oxygenase and is indispensa...

[ 1994, 2006, 2003, 2016 ]

4

[]

[ "IPR031043" ]

0

1

0

[ "Bacteria", "Eukaryota", "Halobacteriales", "Viruses", "metagenomes" ]

[ 10307, 2666, 98, 3, 32 ]

5

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 1 ]

2

true

Family

L-lysine 6-monooxygenase/L-ornithine 5-monooxygenase

Lys/Orn_oxygenase

7

IPR025701

25,701

Ubiquitin-conjugating enzyme, E2, family E

UBQ-conjugat_E2_E

Family

503

false

This entry represents the family E of the E2/UBC superfamily of proteins found in diverse bacteria. Analysis of the active site residues suggest that members of this family are inactive as they lack the characteristic catalytic residues of the E2 enzymes [ , ]. They are usually fused to or in the neighbourhood of a mul...

[]

0

[ "PFAM" ]

[ "PF14462" ]

[ "Prok-E2_E" ]

[ 503 ]

1

[]

0

[ "9eae", "9eav" ]

2

[ "PUB00034476", "PUB00057888" ]

[ "16859499", "18276160" ]

[ "The prokaryotic antecedents of the ubiquitin-signaling system and the early evolution of ubiquitin-like beta-grasp domains.", "Anatomy of the E2 ligase fold: implications for enzymology and evolution of ubiquitin/Ub-like protein conjugation." ]

[ 2006, 2008 ]

2

[]

0

null

[ "Bacteria", "Methanobacteriati", "unclassified sequences" ]

[ 486, 6, 11 ]

3

[]

0

true

Family

Ubiquitin-conjugating enzyme, E2, family E

UBQ-conjugat_E2_E

5

IPR025702

25,702

Aliphatic aldoxime/phenylacetaldoxime dehydratase

OXD

Family

1,799

false

This family includes aldoxime dehydratase ( ). This is a haem-containing enzyme, which catalyses the dehydration of aldoximes to their corresponding nitrile [ ]. The family also includes phenylacetaldoxime dehydratase ( ). This haem-containing enzyme catalyses the dehydration of Z-phenylacetaldoxime to phenylacetonitri...

[]

0

[ "PFAM" ]

[ "PF13816" ]

[ "Dehydratase_hem" ]

[ 1799 ]

1

[ "EC" ]

[ "4.8.1.2" ]

[ "EC:4.8.1.2" ]

1

[ "3a15", "3a16", "3a17", "3a18", "3w08", "7f2y", "7f2z", "7f30" ]

8

[ "PUB00054451", "PUB00057889", "PUB00057890" ]

[ "19740758", "16233624", "10651646" ]

[ "X-ray crystal structure of michaelis complex of aldoxime dehydratase.", "Aldoxime dehydratase co-existing with nitrile hydratase and amidase in the iron-type nitrile hydratase-producer Rhodococcus sp. N-771.", "Novel heme-containing lyase, phenylacetaldoxime dehydratase from Bacillus sp. strain OxB-1: purifica...

[ 2009, 2004, 2000 ]

3

[]

0

null

[ "Bacteria", "Dikarya", "ecological metagenomes" ]

[ 604, 1191, 4 ]

3

[]

0

true

Family

Aliphatic aldoxime/phenylacetaldoxime dehydratase

OXD

7

IPR025703

25,703

Bifunctional protein PutA

Bifunct_PutA

Family

12,408

false

This entry represents PutA, which is a bifunctional enzyme with proline dehydrogenase (PDH) and delta 1-pyrroline-5-carboxylate dehydrogenase (P5CDH) activities [ ]. PutA also acts as a transcriptional repressor of proline utilisation (put) genes [ ].

[ "GO:0003700", "GO:0003842", "GO:0004657", "GO:0006355", "GO:0010133" ]

[ "DNA-binding transcription factor activity", "L-glutamate gamma-semialdehyde dehydrogenase activity", "proline dehydrogenase activity", "regulation of DNA-templated transcription", "L-proline catabolic process to L-glutamate" ]

[ "molecular_function", "molecular_function", "molecular_function", "biological_process", "biological_process" ]

5

[ "PIRSF" ]

[ "PIRSF000197" ]

[ "Bifunct_PutA" ]

[ 12408 ]

1

[ "EC", "EC", "METACYC", "METACYC", "METACYC" ]

[ "1.2.1.88", "1.5.5.2", "PWY-5737", "PWY-6853", "PWY-6922" ]

[ "EC:1.2.1.88", "EC:1.5.5.2", "METACYC:PWY-5737", "METACYC:PWY-6853", "METACYC:PWY-6922" ]

5

[ "3haz", "4nm9", "4nma", "4nmb", "4nmc", "4nmd", "4nme", "4nmf", "4q71", "4q72", "4q73", "5kf6", "5kf7", "5ur2", "5ux5", "6bsn", "6ufp", "6vz9", "6x99", "6x9a", "6x9b", "6x9c", "6x9d", "7my9", "7mya", "7myb", "7myc", "7na0", "9bbo", "9c34", "9c35", "9c36"...

47

[ "PUB00003335", "PUB00026658" ]

[ "7966312", "12514740" ]

[ "Sequence analysis identifies the proline dehydrogenase and delta 1-pyrroline-5-carboxylate dehydrogenase domains of the multifunctional Escherichia coli PutA protein.", "Structure of the proline dehydrogenase domain of the multifunctional PutA flavoprotein." ]

[ 1994, 2003 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 12274, 16, 118 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Bifunctional protein PutA

Bifunct_PutA

9

IPR025704

25,704

E3 ubiquitin ligase UBR4, C-terminal

E3_Ub_ligase_UBR4_C

Domain

3,391

false

Proteins containing this domain includes E3 ubiquitin ligase UBR4 from animals, auxin transport protein BIG from plants and protein purity of essence from fruit flies. UBR4, also known as p600, is a member of the N-recognin family, which contains proven and predicted E3 ligases that recognize and degrade proteins conta...

[]

0

[ "PFAM" ]

[ "PF13764" ]

[ "E3_UbLigase_R4" ]

[ 3391 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-DDI-6798695", "R-DDI-983168", "R-DME-6798695", "R-DME-983168", "R-HSA-6798695", "R-HSA-983168", "R-MMU-6798695", "R-MMU-983168", "R-RNO-6798695", "R-RNO-983168" ]

[ "REACTOME:R-DDI-6798695", "REACTOME:R-DDI-983168", "REACTOME:R-DME-6798695", "REACTOME:R-DME-983168", "REACTOME:R-HSA-6798695", "REACTOME:R-HSA-983168", "REACTOME:R-MMU-6798695", "REACTOME:R-MMU-983168", "REACTOME:R-RNO-6798695", "REACTOME:R-RNO-983168" ]

10

[ "8b5w", "8btl", "9d9z", "9nwd", "9nwe", "9qt9", "9qws", "9qwu", "9qwx", "9qwz", "9qx0", "9qx1", "9qx2", "9qx5" ]

14

[ "PUB00033696", "PUB00057893", "PUB00057894", "PUB00057896", "PUB00057897", "PUB00057898", "PUB00057899", "PUB00057900", "PUB00057901", "PUB00057902", "PUB00057903", "PUB00057904", "PUB00057905", "PUB00057906", "PUB00098225", "PUB00098226" ]

[ "16055722", "16214886", "11485992", "8314087", "9165751", "9390435", "12834402", "15634200", "15681664", "17652113", "19176721", "11517334", "9813038", "8244010", "25424645", "23555265" ]

[ "A family of mammalian E3 ubiquitin ligases that contain the UBR box motif and recognize N-degrons.", "p600, a unique protein required for membrane morphogenesis and cell survival.", "BIG: a calossin-like protein required for polar auxin transport in Arabidopsis.", "Arabidopsis mutants define downstream branc...

[ 2005, 2005, 2001, 1994, 1997, 1997, 2003, 2005, 2005, 2007, 2009, 2001, 1998, 1993, 2015, 2013 ]

16

[]

0

null

[ "Eukaryota" ]

[ 3391 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 8, 2, 51, 2, 8, 2, 2, 3, 18 ]

9

true

Domain

E3 ubiquitin ligase UBR4, C-terminal

E3_Ub_ligase_UBR4_C

8

IPR025705

25,705

Beta-hexosaminidase

GH20

Family

34,489

false

This entry represents beta-hexosaminidase. There are 3 forms of beta-hexosaminidase: hexosaminidase A is a trimer, with one alpha, one beta-A and one beta-B chain; hexosaminidase B is a tetramer of two beta-A and two beta-B chains; and hexosaminidase S is a homodimer of alpha chains. The two beta chains are derived fro...

[ "GO:0004563", "GO:0005975" ]

[ "beta-N-acetylhexosaminidase activity", "carbohydrate metabolic process" ]

[ "molecular_function", "biological_process" ]

2

[ "PIRSF", "PRINTS", "PANTHER" ]

[ "PIRSF001093", "PR00738", "PTHR22600" ]

[ "B-hxosamndse_ab_euk_", "GLHYDRLASE20", "" ]

[ 10449, 33330, 30616 ]

3

[ "EC", "METACYC", "METACYC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "RE...

[ "3.2.1.52", "PWY-6902", "PWY-7822", "PWY-7883", "R-BTA-2022857", "R-BTA-2024101", "R-BTA-2160916", "R-BTA-9840310", "R-CEL-2022857", "R-CEL-2024101", "R-CEL-2160916", "R-CEL-6798695", "R-CEL-9840310", "R-DDI-2022857", "R-DDI-2024101", "R-DDI-2160916", "R-DDI-6798695", "R-DDI-984031...

[ "EC:3.2.1.52", "METACYC:PWY-6902", "METACYC:PWY-7822", "METACYC:PWY-7883", "REACTOME:R-BTA-2022857", "REACTOME:R-BTA-2024101", "REACTOME:R-BTA-2160916", "REACTOME:R-BTA-9840310", "REACTOME:R-CEL-2022857", "REACTOME:R-CEL-2024101", "REACTOME:R-CEL-2160916", "REACTOME:R-CEL-6798695", "REACTOME...

40

[ "1c7s", "1c7t", "1hp4", "1hp5", "1jak", "1m01", "1m03", "1m04", "1nou", "1now", "1np0", "1o7a", "1qba", "1qbb", "1yht", "2gjx", "2gk1", "3gh4", "3gh5", "3gh7", "3lmy", "3nsm", "3nsn", "3ozo", "3ozp", "3rcn", "3s6t", "3sur", "3sus", "3sut", "3suu", "3suv"...

86

[ "PUB00000654", "PUB00097352" ]

[ "8357844", "26024355" ]

[ "Molecular basis of an adult form of Sandhoff disease: substitution of glutamine for arginine at position 505 of the beta-chain of beta-hexosaminidase results in a labile enzyme.", "Structural-Functional Analysis Reveals a Specific Domain Organization in Family GH20 Hexosaminidases." ]

[ 1993, 2015 ]

2

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 33, 20557, 13615, 5, 279 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 12, 1, 5, 11, 32, 11, 2, 15, 12, 28 ]

10

true

Family

Beta-hexosaminidase

GH20

1

IPR025707

25,707

Predicted DNA-binding protein with PD1-like DNA-binding motif

DNA_bp_PD1

Family

1,635

false

This entry represents a predicted DNA-binding protein with PD1-like DNA-binding motif.

[]

0

[ "PIRSF" ]

[ "PIRSF016702" ]

[ "DNA_bp_PD1" ]

[ 1635 ]

1

[]

0

[ "2dt4", "2h6l", "3htn", "3hwu" ]

4

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Trichomonas vaginalis (strain ATCC PRA-98 / G3)", "metagenomes" ]

[ 380, 1221, 1, 33 ]

4

[]

0

true

Family

Predicted DNA-binding protein with PD1-like DNA-binding motif

DNA_bp_PD1

1

IPR025708

25,708

Heat shock protein 15

HSP15

Family

10,348

false

This entry represents heat shock protein 15 (Hsp15), an abundant nucleic acid-binding protein whose RNA synthesis is induced upon temperature upshift [ , ]. The protein contains an RNA-binding motif [ ]. The in vivo target of Hsp15 appears to be the free 50S ribosomal subunit - it does not bind it when it is part of th...

[ "GO:0003677", "GO:0003727", "GO:0043023", "GO:0034605" ]

[ "DNA binding", "single-stranded RNA binding", "ribosomal large subunit binding", "cellular response to heat" ]

[ "molecular_function", "molecular_function", "molecular_function", "biological_process" ]

4

[ "PIRSF" ]

[ "PIRSF016821" ]

[ "HSP15" ]

[ 10348 ]

1

[]

0

[ "1dm9", "5z81", "8ap4" ]

3

[ "PUB00024242", "PUB00057907", "PUB00057908" ]

[ "10675344", "10675343", "9867837" ]

[ "Structure of Hsp15 reveals a novel RNA-binding motif.", "Hsp15: a ribosome-associated heat shock protein.", "A new heat shock protein that binds nucleic acids." ]

[ 2000, 2000, 1999 ]

3

[]

0

null

[ "Bacteria", "Eukaryota", "Siphoviridae sp. ctBLh2", "unclassified sequences" ]

[ 10231, 4, 1, 112 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Heat shock protein 15

HSP15

2

IPR025710

25,710

L-cysteine S-thiosulfotransferase subunit SoxA

SoxA

Family

2,086

false

SoxA protein is a c-type cytochrome with a CxxCH motif. It is part of the SoxAX cytochrome complex that contributes to thiosulfate oxidation to sulfate [ , , ].

[ "GO:0009055", "GO:0016669", "GO:0020037", "GO:0019417", "GO:0070069" ]

[ "electron transfer activity", "oxidoreductase activity, acting on a sulfur group of donors, cytochrome as acceptor", "heme binding", "sulfur oxidation", "cytochrome complex" ]

[ "molecular_function", "molecular_function", "molecular_function", "biological_process", "cellular_component" ]

5

[ "PIRSF", "NCBIFAM" ]

[ "PIRSF038455", "TIGR04484" ]

[ "SoxA", "thiosulf_SoxA" ]

[ 1917, 2086 ]

2

[ "EC", "GP", "METACYC", "METACYC" ]

[ "2.8.5.2", "GenProp1088", "PWY-5296", "PWY-6677" ]

[ "EC:2.8.5.2", "GP:GenProp1088", "METACYC:PWY-5296", "METACYC:PWY-6677" ]

4

[ "1h31", "1h32", "1h33", "2c1d", "2oz1", "3oa8", "3ocd" ]

7

[ "PUB00021732", "PUB00057911", "PUB00074343" ]

[ "12411478", "11567011", "17516047" ]

[ "Structural basis for the oxidation of thiosulfate by a sulfur cycle enzyme.", "Cytochrome complex essential for photosynthetic oxidation of both thiosulfate and sulfide in Rhodovulum sulfidophilum.", "Thiosulfate oxidation by a moderately thermophilic hydrogen-oxidizing bacterium, Hydrogenophilus thermoluteolu...

[ 2002, 2001, 2007 ]

3

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 2028, 6, 52 ]

3

[]

0

true

Family

L-cysteine S-thiosulfotransferase subunit SoxA

SoxA

7

IPR025711

25,711

PepSY domain

PepSY

Domain

25,901

false

This domain is likely to have a protease inhibitory function. The name is derived from peptidase (M4) and YpeB of Bacillus subtilis [ ]. This domain is found in the propeptide of members of the MEROPS peptidase family M4 (clan MA(E)), which contains the thermostable thermolysins ( ), and related thermolabile neutral pr...

[]

0

[ "PFAM", "PFAM" ]

[ "PF03413", "PF13670" ]

[ "PepSY", "PepSY_2" ]

[ 21248, 4691 ]

2

[ "EC" ]

[ "3.4.24" ]

[ "EC:3.4.24" ]

1

[ "2gu3", "3nqy", "3nqz", "4exr", "5a3y", "5boi", "8cr3", "8cr4", "8cr7", "8r1b", "9gm4" ]

11

[ "PUB00020015" ]

[ "15124630" ]

[ "The PepSY domain: a regulator of peptidase activity in the microbial environment?" ]

[ 2004 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences", "uncultured Caudovirales phage" ]

[ 138, 25566, 60, 136, 1 ]

5

[]

0

true

Domain

PepSY domain

PepSY

8

IPR025712

25,712

Nucleoporin Nup54, alpha-helical domain

Nup54_alpha-helical_dom

Domain

4,761

false

This entry represents the α-helical domain of human Nup54. Nup54 interacts with Nup58 via the C-terminal part of this domain and Nup62 via the N-terminal part to form the nucleoporin complex [ ]. Nup54, Nup58 and Nup62 all have similar affinities for importin-beta. It seems likely that they are the only FG-repeat nucle...

[]

0

[ "PFAM" ]

[ "PF13874" ]

[ "Nup54" ]

[ 4761 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-DME-159227", "R-DME-159230", "R-DME-159231", "R-DME-159236", "R-DME-170822", "R-DME-3108214", "R-DME-3301854", "R-DME-4085377", "R-DME-4551638", "R-DME-4615885", "R-DME-5578749", "R-HSA-1169408", "R-HSA-159227", "R-HSA-159230", "R-HSA-159231", "R-HSA-159236", "R-HSA-165054", "R-...

[ "REACTOME:R-DME-159227", "REACTOME:R-DME-159230", "REACTOME:R-DME-159231", "REACTOME:R-DME-159236", "REACTOME:R-DME-170822", "REACTOME:R-DME-3108214", "REACTOME:R-DME-3301854", "REACTOME:R-DME-4085377", "REACTOME:R-DME-4551638", "REACTOME:R-DME-4615885", "REACTOME:R-DME-5578749", "REACTOME:R-H...

85

[ "3t97", "5c3l", "5cws", "5ijn", "5ijo", "7n85", "7n9f", "7per", "7r5j", "7r5k", "7tbi", "7tbj", "7tbk", "7tbl", "7tbm", "7wkk", "7woo", "7wot", "8tj5", "9hcj", "9sob" ]

21

[ "PUB00016425", "PUB00057912", "PUB00057913" ]

[ "12791264", "12656985", "22036567" ]

[ "Peering through the pore: nuclear pore complex structure, assembly, and function.", "Nucleocytoplasmic transport: navigating the channel.", "Molecular architecture of the transport channel of the nuclear pore complex." ]

[ 2003, 2003, 2011 ]

3

[]

0

null

[ "Eukaryota" ]

[ 4761 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 5, 3, 15, 2, 9, 1, 1, 3, 4, 1, 1, 6 ]

12

true

Domain

Nucleoporin Nup54, alpha-helical domain

Nup54_alpha-helical_dom

2

IPR025713

25,713

Motility protein B-like, N-terminal domain

MotB-like_N_dom

Domain

18,742

false

This domain is found in MotB, a component of the Escherichia coli MotA/MotB proton-channel complex that forms the stator of the bacterial membrane flagellar motor. Key residues in MotB act as a plug to prevent premature proton flow. The plug is in the periplasm just C-terminal to the MotB TM (transmembrane helix), cons...

[]

0

[ "PFAM" ]

[ "PF13677" ]

[ "MotB_plug" ]

[ 18742 ]

1

[]

0

[ "6ykm", "6ykp", "6ykr", "6ysf", "6ysl", "8brd", "8bri", "8qyd", "8qyh", "8qyk", "8qyy", "8ucs", "8vvi", "8zyv", "8zyw", "8zyz", "8zz0", "9hmf", "9ijm", "9lu9", "9lub", "9luc" ]

22

[ "PUB00035647", "PUB00057914", "PUB00097806" ]

[ "17052729", "14705929", "29371424" ]

[ "The Escherichia coli MotAB proton channel unplugged.", "Arrangement of core membrane segments in the MotA/MotB proton-channel complex of Escherichia coli.", "Systematic discovery of antiphage defense systems in the microbial pangenome." ]

[ 2006, 2004, 2018 ]

3

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 18440, 17, 285 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Domain

Motility protein B-like, N-terminal domain

MotB-like_N_dom

1

IPR025714

25,714

Methyltransferase domain

Methyltranfer_dom

Domain

79,193

false

This domain appears to be a methyltransferase domain.

[]

0

[ "PFAM", "PFAM", "PFAM" ]

[ "PF13383", "PF13679", "PF13847" ]

[ "Methyltransf_22", "Methyltransf_32", "Methyltransf_31" ]

[ 3882, 15375, 59936 ]

3

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "2.1.1", "R-DRE-8876725", "R-DRE-9854311", "R-HSA-156581", "R-HSA-8876725", "R-HSA-9854311", "R-MMU-156581", "R-MMU-389661", "R-MMU-8876725", "R-RNO-156581", "R-SCE-8876725", "R-SPO-8876725" ]

[ "EC:2.1.1", "REACTOME:R-DRE-8876725", "REACTOME:R-DRE-9854311", "REACTOME:R-HSA-156581", "REACTOME:R-HSA-8876725", "REACTOME:R-HSA-9854311", "REACTOME:R-MMU-156581", "REACTOME:R-MMU-389661", "REACTOME:R-MMU-8876725", "REACTOME:R-RNO-156581", "REACTOME:R-SCE-8876725", "REACTOME:R-SPO-8876725" ]

12

[ "1f38", "1kxz", "1l3b", "1l3c", "1l3i", "1p91", "1r8x", "1r8y", "2gh1", "2yxd", "3bkx", "3dh0", "3g5t", "3gu3", "3htx", "3mgg", "3ujc", "4ax8", "4azs", "4azt", "4azv", "4azw", "4fr0", "4fs8", "4fsd", "4htf", "4kvz", "4kw7", "4rsr", "4uw0", "5bxy", "5dly"...

59

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 1832, 42992, 33084, 30, 1255 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus",...

[ 43, 13, 26, 10, 2, 21, 15, 5, 22, 30, 2, 2, 80 ]

13

true

Domain

Methyltransferase domain

Methyltranfer_dom

9

IPR025715

25,715

Chromatin target of PRMT1 protein, C-terminal

FoP_C

Domain

9,201

false

This LDXXLDAYM region (where X is any amino acid) is duplicated in the C terminus of chromatin target of PRMT1 protein (also known as Fop), which are chromatin-associated proteins that co-localise with facultative heterochromatin and are critical for oestrogen-dependent gene activation [ ]. The region also occurs in ot...

[]

0

[ "PFAM", "SMART" ]

[ "PF13865", "SM01218" ]

[ "FoP_duplication", "FoP_duplication" ]

[ 8026, 8538 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-159227", "R-BTA-159230", "R-BTA-159231", "R-BTA-159236", "R-BTA-72163", "R-BTA-72187", "R-BTA-73856", "R-HSA-159227", "R-HSA-159230", "R-HSA-159231", "R-HSA-159236", "R-HSA-72163", "R-HSA-72187", "R-HSA-73856", "R-MMU-159227", "R-MMU-159230", "R-MMU-159231", "R-MMU-159236", ...

[ "REACTOME:R-BTA-159227", "REACTOME:R-BTA-159230", "REACTOME:R-BTA-159231", "REACTOME:R-BTA-159236", "REACTOME:R-BTA-72163", "REACTOME:R-BTA-72187", "REACTOME:R-BTA-73856", "REACTOME:R-HSA-159227", "REACTOME:R-HSA-159230", "REACTOME:R-HSA-159231", "REACTOME:R-HSA-159236", "REACTOME:R-HSA-72163"...

29

[ "7znk" ]

1

[ "PUB00057915" ]

[ "19858291" ]

[ "Friend of Prmt1, a novel chromatin target of protein arginine methyltransferases." ]

[ 2010 ]

1

[]

0

null

[ "Eukaryota" ]

[ 9201 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 22, 3, 8, 2, 5, 14, 2, 21, 12, 1, 2, 27 ]

12

true

Domain

Chromatin target of PRMT1 protein, C-terminal

FoP_C

3

IPR025716

25,716

Post-transcriptional regulator

Post-transcriptional_regulator

Family

1,692

false

This entry includes post-transcriptional regulators such as YrzD, which is renamed to ComN. The comN gene is a regulatory factor in competence development that functions through the 5'-UTR of the comE operon [ ].

[]

0

[ "PFAM" ]

[ "PF13797" ]

[ "Post_transc_reg" ]

[ 1692 ]

1

[]

0

[]

0

[ "PUB00057916" ]

[ "19028902" ]

[ "The Bacillus subtilis late competence operon comE is transcriptionally regulated by yutB and under post-transcription initiation control by comN (yrzD)." ]

[ 2009 ]

1

[]

0

null

[ "Bacteria", "Rhizophagus irregularis", "metagenomes" ]

[ 1689, 1, 2 ]

3

[]

0

true

Family

Post-transcriptional regulator

Post-transcriptional_regulator

9

IPR025717

25,717

Histone deacetylase complex subunit SAP30 zinc-finger

SAP30_zn-finger

Domain

2,013

false

SAP30 is a subunit of the histone deacetylase complex, and this domain is a zinc-finger. Solution of the structure shows a novel fold comprising two β-strands and two α-helices with the zinc organising centre showing remote resemblance to the treble clef motif. In silico analysis of the structure reveals a highly conse...

[]

0

[ "PFAM" ]

[ "PF13866" ]

[ "zf-SAP30" ]

[ 2013 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-DME-3214815", "R-HSA-3214815", "R-HSA-427413", "R-HSA-9679191", "R-MMU-3214815", "R-XTR-3214815" ]

[ "REACTOME:R-DME-3214815", "REACTOME:R-HSA-3214815", "REACTOME:R-HSA-427413", "REACTOME:R-HSA-9679191", "REACTOME:R-MMU-3214815", "REACTOME:R-XTR-3214815" ]

6

[ "2kdp", "2n1u" ]

2

[ "PUB00048323" ]

[ "19223330" ]

[ "Solution structure of a novel zinc finger motif in the SAP30 polypeptide of the Sin3 corepressor complex and its potential role in nucleic acid recognition." ]

[ 2009 ]

1

[]

0

null

[ "Metazoa" ]

[ 2013 ]

1

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 2, 2, 2, 4 ]

5

true

Domain

Histone deacetylase complex subunit SAP30 zinc-finger

SAP30_zn-finger

9

IPR025718

25,718

Histone deacetylase complex subunit SAP30, Sin3 binding domain

SAP30_Sin3-bd

Domain

5,392

false

This C-terminal domain of the SAP30 proteins appears to be the binding region for Sin3 [ ].

[ "GO:0005515" ]

[ "protein binding" ]

[ "molecular_function" ]

1

[ "PFAM" ]

[ "PF13867" ]

[ "SAP30_Sin3_bdg" ]

[ 5392 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-DME-3214815", "R-HSA-3214815", "R-HSA-427413", "R-HSA-9679191", "R-MMU-3214815", "R-SCE-3214815", "R-XTR-3214815" ]

[ "REACTOME:R-DME-3214815", "REACTOME:R-HSA-3214815", "REACTOME:R-HSA-427413", "REACTOME:R-HSA-9679191", "REACTOME:R-MMU-3214815", "REACTOME:R-SCE-3214815", "REACTOME:R-XTR-3214815" ]

7

[ "2ld7", "8ga8", "8hpo" ]

3

[ "PUB00057917" ]

[ "9651585" ]

[ "SAP30, a novel protein conserved between human and yeast, is a component of a histone deacetylase complex." ]

[ 1998 ]

1

[]

0

null

[ "Cytobacillus praedii", "Eukaryota" ]

[ 1, 5391 ]

2

[ "Arabidopsis thaliana", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "...

[ 11, 1, 2, 2, 2, 1, 8, 3, 1, 9 ]

10

true

Domain

Histone deacetylase complex subunit SAP30, Sin3 binding domain

SAP30_Sin3-bd

4

IPR025719

25,719

Myelin gene regulatory factor C-terminal domain 2

MYRF_C2

Domain

2,336

false

Myelin regulatory factor (Myrf) is a transcription regulator required in vertebrates for expression of central nervous system (CNS) myelin genes such as Mbp and Mog, thereby playing a central role in oligodendrocyte maturation and CNS myelination [ ]. It is also required for the maintenance of expression of myelin gene...

[]

0

[ "PFAM" ]

[ "PF13888" ]

[ "MRF_C2" ]

[ 2336 ]

1

[]

0

[]

0

[ "PUB00057918", "PUB00062039", "PUB00062040", "PUB00062316", "PUB00095183" ]

[ "19596243", "22811266", "21989027", "22956843", "31964908" ]

[ "Myelin gene regulatory factor is a critical transcriptional regulator required for CNS myelination.", "An orthologue of the Myelin-gene Regulatory Transcription Factor regulates Dictyostelium prestalk differentiation.", "Regulation of the C. elegans molt by pqn-47.", "Myelin gene regulatory factor is require...

[ 2009, 2012, 2011, 2012, 2020 ]

5

[]

0

null

[ "Eumetazoa" ]

[ 2336 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 15, 10, 3, 7 ]

5

true

Domain

Myelin gene regulatory factor C-terminal domain 2

MYRF_C2

6

IPR025720

25,720

ECF transporter, Riboflavin transporter RibU

RibU

Family

4,719

false

This entry represents the riboflavin ECF transporter S component RibU which mediates riboflavin uptake and may also transport FMN and roseoflavin [ ]. The crystal structure of RibU from Staphylococcus aureus ( ) has been solved, revealing the protein to possess six transmembrane segments and to adopt a previously unrep...

[ "GO:0032217", "GO:0032218", "GO:0005886" ]

[ "riboflavin transmembrane transporter activity", "riboflavin transport", "plasma membrane" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PIRSF", "PANTHER" ]

[ "PIRSF037778", "PTHR38438" ]

[ "UCP037778_transp_RibU", "" ]

[ 4336, 4719 ]

2

[]

0

[ "3p5n", "5kbw", "5kc0", "5kc4" ]

4

[ "PUB00056162", "PUB00057920", "PUB00057921", "PUB00061689" ]

[ "18931129", "16585736", "20972419", "17288550" ]

[ "A novel class of modular transporters for vitamins in prokaryotes.", "The riboflavin transporter RibU in Lactococcus lactis: molecular characterization of gene expression and the transport mechanism.", "Structure and mechanism of the S component of a bacterial ECF transporter.", "The bile/arsenite/riboflavin...

[ 2009, 2006, 2010, 2007 ]

4

[ "IPR024529" ]

[]

1

0

1

[ "Archaea", "Bacteria", "Rhizophagus irregularis", "metagenomes", "unclassified Caudoviricetes" ]

[ 20, 4658, 1, 38, 2 ]

5

[]

0

true

Family

ECF transporter, Riboflavin transporter RibU

RibU

1

IPR025721

25,721

Exosome complex component, N-terminal domain

Exosome_cplx_N_dom

Domain

7,310

false

This entry represents a domain found in the N-terminal region of some exosome complex components, including ribosomal RNA-processing protein 4 (RRP4) and CSL4. It is a G-rich domain which structurally is a rudimentary single hybrid fold with a permuted topology.

[]

0

[ "PFAM" ]

[ "PF14382" ]

[ "ECR1_N" ]

[ 7310 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-429958", "R-BTA-450385", "R-BTA-450513", "R-BTA-450604", "R-BTA-6791226", "R-BTA-9930044", "R-CEL-429958", "R-CEL-450385", "R-CEL-450513", "R-CEL-6791226", "R-CEL-9930044", "R-HSA-380994", "R-HSA-429958", "R-HSA-450385", "R-HSA-450513", "R-HSA-450604", "R-HSA-6791226", "R-HS...

[ "REACTOME:R-BTA-429958", "REACTOME:R-BTA-450385", "REACTOME:R-BTA-450513", "REACTOME:R-BTA-450604", "REACTOME:R-BTA-6791226", "REACTOME:R-BTA-9930044", "REACTOME:R-CEL-429958", "REACTOME:R-CEL-450385", "REACTOME:R-CEL-450513", "REACTOME:R-CEL-6791226", "REACTOME:R-CEL-9930044", "REACTOME:R-HSA...

30

[ "2ba1", "2nn6", "3m7n", "3m85", "4ifd", "4oo1", "5c0w", "5c0x", "5g06", "5jea", "5k36", "5okz", "5vzj", "6d6q", "6d6r", "6fsz", "6h25", "6lqs", "7ajt", "7aju", "7d4i", "8pel", "8qcf", "8r1o", "9g8m", "9g8n", "9g8o", "9g8p" ]

28

[]

0

[]

0

null

[ "Archaea", "Desulfofervidus auxilii", "Eukaryota", "unclassified sequences" ]

[ 422, 1, 6865, 22 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizo...

[ 9, 2, 2, 4, 15, 6, 2, 9, 1, 1, 4 ]

11

true

Domain

Exosome complex component, N-terminal domain

Exosome_cplx_N_dom

1

IPR025722

25,722

Bacterial transcriptional repressor TetR

TetR

Family

4,571

false

This family of bacterial transcriptional repressors is characterised by the short approximately 50 amino acid stretch of residues constituting the helix-turn-helix DNA binding motif, around the YRFhY motif. The target proteins that are repressed are involved in the transcriptional control of multi-drug efflux pumps, pa...

[]

0

[ "PFAM" ]

[ "PF13972" ]

[ "TetR" ]

[ 4571 ]

1

[]

0

[ "3nnr", "3rh2" ]

2

[ "PUB00035985" ]

[ "15944459" ]

[ "The TetR family of transcriptional repressors." ]

[ 2005 ]

1

[]

0

null

[ "Bacteria", "Opisthokonta", "ecological metagenomes" ]

[ 4550, 3, 18 ]

3

[]

0

true

Family

Bacterial transcriptional repressor TetR

TetR

6

IPR025723

25,723

ArsA/GET3, Anion-transporting ATPase-like domain

ArsA/GET3_ATPase-like

Domain

22,467

false

This entry represents a conserved domain in ArsA/GET3 proteins [ , ]. This entry also matches some sequences from the Mrp/NBP35 ATP-binding proteins family and related ATPases. Active extrusion is a common mechanism for the detoxification of heavy metals, drugs and antibiotics in bacteria, protozoa and mammals. This is...

[]

0

[ "PFAM" ]

[ "PF02374" ]

[ "ArsA_ATPase" ]

[ 22467 ]

1

[ "REACTOME" ]

[ "R-HSA-9609523" ]

[ "REACTOME:R-HSA-9609523" ]

1

[ "1f48", "1ihu", "1ii0", "1ii9", "2woj", "2woo", "3a36", "3a37", "3b2e", "3h84", "3ibg", "3idq", "3igf", "3io3", "3iqw", "3iqx", "3sja", "3sjb", "3sjc", "3sjd", "3ug6", "3ug7", "3vlc", "3zq6", "3zs8", "3zs9", "4pwx", "4xtr", "4xvu", "4xwo", "5bw8", "5bwk"...

58

[ "PUB00007982", "PUB00024783", "PUB00043521", "PUB00056211", "PUB00056212", "PUB00056213", "PUB00056214", "PUB00057861", "PUB00057862" ]

[ "1704144", "10970874", "17419726", "12680698", "17289575", "18724936", "20981284", "21658170", "20406421" ]

[ "The plasmid-encoded arsenical resistance pump: an anion-translocating ATPase.", "Structure of the ArsA ATPase: the catalytic subunit of a heavy metal resistance pump.", "Caenorhabditis elegans expresses a functional ArsA.", "The Saccharomyces cerevisiae Arr4p is involved in metal and heat tolerance.", "ASN...

[ 1990, 2000, 2007, 2003, 2007, 2008, 2010, 2011, 2010 ]

9

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 1101, 14288, 6745, 333 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 19, 1, 1, 2, 2, 4, 1, 9, 3, 1, 1, 33 ]

12

true

Domain

ArsA/GET3, Anion-transporting ATPase-like domain

ArsA/GET3_ATPase-like

2

IPR025725

25,725

E3 ubiquitin-protein ligase SopA-like, catalytic domain

SopA-like_cat

Domain

1,093

false

This domain is found in the Escherichia coli Type III secretion effector proteins SopA and NleL [ , ]. These proteins have been shown to act as E3 ubiquitin ligase enzymes. This domain contains the active site cysteine residue.

[ "GO:0004842", "GO:0016567" ]

[ "ubiquitin-protein transferase activity", "protein ubiquitination" ]

[ "molecular_function", "biological_process" ]

2

[ "PFAM" ]

[ "PF13979" ]

[ "SopA_C" ]

[ 1093 ]

1

[ "EC", "METACYC" ]

[ "2.3.2.26", "PWY-7511" ]

[ "EC:2.3.2.26", "METACYC:PWY-7511" ]

2

[ "2qyu", "2qza", "3naw", "3nb2", "3sqv", "3sy2", "8st7", "8st8", "8st9" ]

9

[ "PUB00049190", "PUB00057922" ]

[ "18066077", "20980253" ]

[ "Crystal structure of SopA, a Salmonella effector protein mimicking a eukaryotic ubiquitin ligase.", "Biochemical and structural studies of a HECT-like ubiquitin ligase from Escherichia coli O157:H7." ]

[ 2008, 2011 ]

2

[]

0

null

[ "Pseudomonadati", "human gut metagenome" ]

[ 1091, 2 ]

2

[]

0

true

Domain

E3 ubiquitin-protein ligase SopA-like, catalytic domain

SopA-like_cat

9

IPR025726

25,726

E3 ubiquitin ligase SopA-like central domain

SopA-like_central

Domain

1,247

false

This domain is found in the E. coli Type III secretion effector proteins SopA and NleL [ , ]. These proteins have been shown to act as E3 ubiquitin ligase enzymes.

[]

0

[ "PFAM" ]

[ "PF13981" ]

[ "SopA" ]

[ 1247 ]

1

[ "EC", "METACYC" ]

[ "2.3.2.26", "PWY-7511" ]

[ "EC:2.3.2.26", "METACYC:PWY-7511" ]

2

[ "2qyu", "2qza", "3naw", "3nb2", "3sqv", "3sy2", "5jw7" ]

7

[ "PUB00049190", "PUB00057922" ]

[ "18066077", "20980253" ]

[ "Crystal structure of SopA, a Salmonella effector protein mimicking a eukaryotic ubiquitin ligase.", "Biochemical and structural studies of a HECT-like ubiquitin ligase from Escherichia coli O157:H7." ]

[ 2008, 2011 ]

2

[]

0

null

[ "Pseudomonadota", "human gut metagenome" ]

[ 1245, 2 ]

2

[ "Escherichia coli (strain K12)" ]

[ 2 ]

1

true

Domain

E3 ubiquitin ligase SopA-like central domain

SopA-like_central

5

IPR025727

25,727

YbfN-like lipoprotein

YbfN-like

Family

884

false

This family of proteins is functionally uncharacterised and is found in bacteria. Members of this family are lipoproteins of approximately 110 amino acids in length.

[]

0

[ "PFAM" ]

[ "PF13982" ]

[ "YbfN" ]

[ 884 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Gammaproteobacteria", "bioreactor metagenome" ]

[ 883, 1 ]

2

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

YbfN-like lipoprotein

YbfN-like

2

IPR025728

25,728

YsaB-like lipoprotein

YsaB-like

Family

795

false

This family of proteins is functionally uncharacterised. These proteins are related to Escherichia coli YsaB ( ). This family of proteins is found in bacteria. Proteins in this family are lipoproteins and they are approximately 100 amino acids in length.

[]

0

[ "PFAM" ]

[ "PF13983" ]

[ "YsaB" ]

[ 795 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "metagenomes" ]

[ 792, 3 ]

2

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

YsaB-like lipoprotein

YsaB-like

5

IPR025729

25,729

MsyB protein

MsyB

Family

912

false

The MsyB protein has been found to be able to restore protein export defects caused by a temperature-sensitive secY or secA mutation [ ]. Its exact molecular function is still unknown, but it may play a role in protein export. Proteins in this family are approximately 120 amino acids in length and are found in bacteria...

[]

0

[ "NCBIFAM", "PFAM" ]

[ "NF008544", "PF13984" ]

[ "PRK11467.1", "MsyB" ]

[ 880, 912 ]

2

[]

0

[ "8imq" ]

1

[ "PUB00057923" ]

[ "1537791" ]

[ "Multicopy suppression: an approach to understanding intracellular functioning of the protein export system." ]

[ 1992 ]

1

[]

0

null

[ "Opisthokonta", "Pseudomonadota", "human gut metagenome" ]

[ 3, 908, 1 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

MsyB protein

MsyB

2

IPR025730

25,730

Biofilm regulator BssS

Biofilm_BssS

Family

1,174

false

The BssS protein family is a group of proteins that are involved in regulation of biofilm formation [ ]. Proteins in this family are approximately 80 amino acids in length.

[]

0

[ "PFAM" ]

[ "PF13991" ]

[ "BssS" ]

[ 1174 ]

1

[]

0

[]

0

[ "PUB00044175" ]

[ "16597943" ]

[ "YliH (BssR) and YceP (BssS) regulate Escherichia coli K-12 biofilm formation by influencing cell signaling." ]

[ 2006 ]

1

[]

0

null

[ "Bacteria", "Neoptera", "ecological metagenomes" ]

[ 1168, 2, 4 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Biofilm regulator BssS

Biofilm_BssS

3

IPR025731

25,731

YecR-like lipoprotein

YecR-like

Domain

905

false

This entry represents YecR-like lipoproteins including the YecR protein from Escherichia coli ( ). These proteins are found in bacteria and viruses and are functionally uncharacterised. These proteins are approximately 110 amino acids in length.

[]

0

[ "PFAM" ]

[ "PF13992" ]

[ "YecR" ]

[ 905 ]

1

[]

0

[ "7bgl" ]

1

[]

0

[]

0

null

[ "Beauveria bassiana D1-5", "Bordetella phage BPP-1", "Pseudomonadati" ]

[ 1, 1, 903 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Domain

YecR-like lipoprotein

YecR-like

9

IPR025732

25,732

MarB protein

MarB

Family

744

false

The MarB protein is found in the multiple antibiotic resistance (mar) locus in Escherichia coli [ ]. The MarB protein is functionally uncharacterised. Proteins in this family are approximately 70 amino acids in length and contain a conserved GSDKSD sequence motif.

[]

0

[ "NCBIFAM", "PFAM" ]

[ "NF007508", "PF13999" ]

[ "PRK10106.1", "MarB" ]

[ 703, 744 ]

2

[]

0

[]

0

[ "PUB00057926" ]

[ "8383113" ]

[ "Genetic and functional analysis of the multiple antibiotic resistance (mar) locus in Escherichia coli." ]

[ 1993 ]

1

[]

0

null

[ "Beauveria bassiana D1-5", "Pseudomonadati", "bioreactor metagenome" ]

[ 1, 742, 1 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

MarB protein

MarB

1

IPR025733

25,733

Purple acid phosphatase, C-terminal domain

PAPs_C

Domain

16,198

false

This domain is found at the C-terminal of purple acid phosphatase proteins (PAPs) and related acid phosphatase proteins. It acquires a fold consisting of two sandwiched β-sheets flanked by α-helical segments [ , ]. Purple acid phosphatases (PAPs) ( ) are a family of binuclear metallohydrolases that break down phosphate...

[]

0

[ "PFAM" ]

[ "PF14008" ]

[ "Metallophos_C" ]

[ 16198 ]

1

[ "EC", "METACYC" ]

[ "3.1.3.2", "PWY-6348" ]

[ "EC:3.1.3.2", "METACYC:PWY-6348" ]

2

[ "1kbp", "1xzw", "2qfp", "2qfr", "3kbp", "3zk4", "4dhl", "4dsy", "4dt2", "4kbp", "6g46", "6git", "6giz", "6gj2", "6gj9", "6gja", "6hwr", "6of5", "6ofd", "6py9", "6vj7", "8brn" ]

22

[ "PUB00010642", "PUB00057927", "PUB00089454", "PUB00089455", "PUB00091382", "PUB00160375" ]

[ "10510276", "12021284", "7770774", "16793224", "25075326", "37985663" ]

[ "Binuclear metal centers in plant purple acid phosphatases: Fe-Mn in sweet potato and Fe-Zn in soybean.", "Purple acid phosphatases of Arabidopsis thaliana. Comparative analysis and differential regulation by phosphate deprivation.", "Crystal structure of a purple acid phosphatase containing a dinuclear Fe(III)...

[ 1999, 2002, 1995, 2006, 2014, 2023 ]

6

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "metagenomes", "unclassified Marseilleviridae" ]

[ 13, 79, 16099, 5, 2 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 80, 8, 1, 4, 1, 2, 2, 71, 3, 103 ]

10

true

Domain

Purple acid phosphatase, C-terminal domain

PAPs_C

8

IPR025734

25,734

EspG family

EspG

Family

5,786

false

This entry includes the EspG1, EspG2, EspG3 and EspG5 proteins from Mycobacterium tuberculosis. These proteins are involved in the ESAT-6 secretion system 1 (ESX-1) of Mycobacterium tuberculosis which is important for virulence and intercellular spread [ ].

[]

0

[ "PFAM" ]

[ "PF14011" ]

[ "ESX-1_EspG" ]

[ 5786 ]

1

[]

0

[ "4kxr", "4l4w", "4rcl", "4w4i", "4w4j", "4w4l", "5dlb", "5sxl", "5vba", "5xfs", "5xkl", "6uuj", "6vhr", "6vj5" ]

14

[ "PUB00057928" ]

[ "17433643" ]

[ "A protein linkage map of the ESAT-6 secretion system 1 (ESX-1) of Mycobacterium tuberculosis." ]

[ 2009 ]

1

[]

0

null

[ "Bacillati", "freshwater metagenome" ]

[ 5784, 2 ]

2

[]

0

true

Family

EspG family

EspG

2

IPR025735

25,735

RIP homotypic interaction motif

RHIM

Binding_site

1,464

false

This entry represents the RHIM (RIP homotypic interaction motif) binding site found in receptor-interacting serine/threonine-protein kinases or cell death proteins [ ], including human Z-DNA-binding protein 1 (ZBP1, also known as DAI) is involved in virus recognition. This motif is necessary for the recruitment of RIP ...

[]

0

[ "PFAM" ]

[ "PF12721" ]

[ "RHIM" ]

[ 1464 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-HSA-140534", "R-HSA-1606322", "R-HSA-1606341", "R-HSA-166166", "R-HSA-168164", "R-HSA-168927", "R-HSA-1810476", "R-HSA-2562578", "R-HSA-3134975", "R-HSA-3295583", "R-HSA-5213460", "R-HSA-5602566", "R-HSA-5602571", "R-HSA-5675482", "R-HSA-9013957", "R-HSA-9013973", "R-HSA-9014325",...

[ "REACTOME:R-HSA-140534", "REACTOME:R-HSA-1606322", "REACTOME:R-HSA-1606341", "REACTOME:R-HSA-166166", "REACTOME:R-HSA-168164", "REACTOME:R-HSA-168927", "REACTOME:R-HSA-1810476", "REACTOME:R-HSA-2562578", "REACTOME:R-HSA-3134975", "REACTOME:R-HSA-3295583", "REACTOME:R-HSA-5213460", "REACTOME:R-...

52

[ "5v7z", "6jpd", "7da4", "7dac", "8ib0", "8rlm", "8z93", "8z94", "9hr6", "9hr9", "9m6m" ]

11

[ "PUB00057929", "PUB00057930", "PUB00057931", "PUB00155424" ]

[ "11734559", "19590578", "15814722", "32200799" ]

[ "Identification of a novel homotypic interaction motif required for the phosphorylation of receptor-interacting protein (RIP) by RIP3.", "DAI/ZBP1 recruits RIP1 and RIP3 through RIP homotypic interaction motifs to activate NF-kappaB.", "Apoptosis induced by the toll-like receptor adaptor TRIF is dependent on it...

[ 2002, 2009, 2005, 2020 ]

4

[]

0

null

[ "Bacteria", "Bilateria", "Herpesvirales" ]

[ 48, 1402, 14 ]

3

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 6, 7, 10 ]

4

true

Binding_site

RIP homotypic interaction motif

RHIM

5