LiteFold/InterPro · Datasets at Hugging Face

IPR025505

25,505

FHIPEP conserved site

FHIPEP_CS

Conserved_site

13,333

false

A number of bacterial proteins seem to be involved in translocating specific proteins across the bacterial cell membrane by a distinct secretory mechanism that does not require the cleavage of a signal peptide. They belong to the FHIPEP family, which stands for Flagella/Hr/Invasion Proteins Export Pore [ , , ]. The N-t...

[]

0

[ "PROSITE" ]

[ "PS00994" ]

[ "FHIPEP" ]

[ 13333 ]

1

[]

0

[ "7alw", "7amy", "7awa" ]

3

[ "PUB00002235", "PUB00003759", "PUB00003838" ]

[ "8253684", "8316211", "8097015" ]

[ "HrpI of Erwinia amylovora functions in secretion of harpin and is a member of a new protein family.", "Homology between the HrpO protein of Pseudomonas solanacearum and bacterial proteins implicated in a signal peptide-independent secretion mechanism.", "Bacillus subtilis FlhA: a flagellar protein related to a...

[ 1993, 1993, 1993 ]

3

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 13207, 18, 108 ]

3

[ "Escherichia coli (strain K12)" ]

[ 2 ]

1

true

Conserved_site

FHIPEP conserved site

FHIPEP_CS

4

IPR025506

25,506

Abortive infection alpha

Abi_alpha

Family

1,519

false

Enterococci such as Enterococcus faecalis and Enterococcus faecium are part of the normal human gut microbiota. However they can also be a source of nosocomial infections specially in immunocompromised patients. Virulent bacteriophages, i.e., viruses that infect and obligatorily lyse bacteria might provide alternative ...

[]

0

[ "PFAM" ]

[ "PF14337" ]

[ "Abi_alpha" ]

[ 1519 ]

1

[]

0

[ "3h35" ]

1

[ "PUB00101291" ]

[ "30634666" ]

[ "Enterococcus faecalis Countermeasures Defeat a Virulent Picovirinae Bacteriophage." ]

[ 2019 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "Stenosarchaea group", "Viruses", "ecological metagenomes" ]

[ 1460, 3, 16, 30, 10 ]

5

[]

0

true

Family

Abortive infection alpha

Abi_alpha

2

IPR025508

25,508

Domain of unknown function DUF4395

DUF4395

Domain

4,440

false

This domain is functionally uncharacterised. There are two completely conserved C residues that may be functionally important.

[]

0

[ "PFAM" ]

[ "PF14340" ]

[ "DUF4395" ]

[ 4440 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Halobacteriales", "metagenomes" ]

[ 4108, 106, 14, 212 ]

4

[]

0

true

Domain

Domain of unknown function DUF4395

DUF4395

4

IPR025509

25,509

Domain of unknown function DUF4396

DUF4396

Domain

3,590

false

The function of this domain is not known.

[]

0

[ "PFAM" ]

[ "PF14342" ]

[ "DUF4396" ]

[ 3590 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 124, 2738, 658, 70 ]

4

[]

0

true

Domain

Domain of unknown function DUF4396

DUF4396

7

IPR025511

25,511

Domain of unknown function DUF4398

DUF4398

Domain

4,919

false

This presumed domain is functionally uncharacterised.

[]

0

[ "PFAM" ]

[ "PF14346" ]

[ "DUF4398" ]

[ 4919 ]

1

[]

0

[ "4fm3" ]

1

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "ecological metagenomes" ]

[ 4885, 5, 29 ]

3

[]

0

true

Domain

Domain of unknown function DUF4398

DUF4398

5

IPR025513

25,513

Domain of unknown function DUF4401

DUF4401

Domain

1,220

false

The function of this domain is not known. There is a single completely conserved residue K that may be functionally important.

[]

0

[ "PFAM" ]

[ "PF14351" ]

[ "DUF4401" ]

[ 1220 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Tanacetum cinerariifolium", "unclassified sequences" ]

[ 1203, 1, 16 ]

3

[]

0

true

Domain

Domain of unknown function DUF4401

DUF4401

2

IPR025514

25,514

Protein of unknown function DUF4402

DUF4402

Family

1,404

false

This family of proteins is functionally uncharacterised.

[]

0

[ "PFAM" ]

[ "PF14352" ]

[ "DUF4402" ]

[ 1404 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "ecological metagenomes" ]

[ 1389, 15 ]

2

[]

0

true

Family

Protein of unknown function DUF4402

DUF4402

5

IPR025515

25,515

Protein of unknown function DUF4403

DUF4403

Family

1,568

false

This family of proteins is functionally uncharacterised. There is a single completely conserved residue W that may be functionally important.

[]

0

[ "PFAM" ]

[ "PF14356" ]

[ "DUF4403" ]

[ 1568 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "ecological metagenomes" ]

[ 1556, 3, 9 ]

3

[]

0

true

Family

Protein of unknown function DUF4403

DUF4403

8

IPR025516

25,516

Protein of unknown function DUF4404

DUF4404

Family

1,261

false

This family of proteins is functionally uncharacterised. There are two completely conserved residues (P and G) that may be functionally important.

[]

0

[ "PFAM" ]

[ "PF14357" ]

[ "DUF4404" ]

[ 1261 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Fusarium", "metagenomes" ]

[ 1245, 3, 13 ]

3

[]

0

true

Family

Protein of unknown function DUF4404

DUF4404

3

IPR025517

25,517

Flavinylation-associated cytochrome domain

DUF4405

Domain

1,838

false

This domain is found in a group of uncharacterised prokaryotic proteins. Proteins in this group are thought to mediate flavinylation-associated electron transfer in the cytoplasmic membrane and constitute a novel class of cytochromes. There are two conserved histidines in this domain, which are predicted to bind to two...

[]

0

[ "PFAM" ]

[ "PF14358" ]

[ "DUF4405" ]

[ 1838 ]

1

[]

0

[]

0

[ "PUB00160945" ]

[ "39041811" ]

[ "Versatile roles of protein flavinylation in bacterial extracyotosolic electron transfer." ]

[ 2024 ]

1

[]

0

null

[ "Archaea", "Bacteria", "metagenomes" ]

[ 134, 1676, 28 ]

3

[]

0

true

Domain

Flavinylation-associated cytochrome domain

DUF4405

8

IPR025518

25,518

Protein of unknown function DUF4406

DUF4406

Family

1,657

false

This family of proteins is functionally uncharacterised.

[]

0

[ "PFAM" ]

[ "PF14359" ]

[ "DUF4406" ]

[ 1657 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Candidatus Nitrosotalea okcheonensis", "Opisthokonta", "Viruses", "unclassified sequences" ]

[ 1263, 1, 3, 298, 92 ]

5

[]

0

true

Family

Protein of unknown function DUF4406

DUF4406

3

IPR025519

25,519

Protein of unknown function DUF4407

DUF4407

Family

2,822

false

This family of proteins has not been characterised. There is a single completely conserved residue R that may be functionally important.

[]

0

[ "PFAM" ]

[ "PF14362" ]

[ "DUF4407" ]

[ 2822 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Caudoviricetes code 15 clade", "Opisthokonta", "metagenomes" ]

[ 2799, 3, 6, 14 ]

4

[]

0

true

Family

Protein of unknown function DUF4407

DUF4407

6

IPR025520

25,520

Domain of unknown function DUF4408

DUF4408

Domain

3,469

false

This domain of unknown function is found at the N-terminal of the pathogen-associated molecular patterns-induced protein A70 from Arabidopsis thaliana and other plant proteins.

[]

0

[ "PFAM" ]

[ "PF14364" ]

[ "DUF4408" ]

[ 3469 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Massilia aquatica", "Tracheophyta" ]

[ 1, 3468 ]

2

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 48, 23, 24 ]

3

true

Domain

Domain of unknown function DUF4408

DUF4408

1

IPR025522

25,522

Protein of unknown function DUF4410

DUF4410

Family

700

false

This family of proteins is functionally uncharacterised.

[]

0

[ "PFAM" ]

[ "PF14366" ]

[ "DUF4410" ]

[ 700 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "metagenomes" ]

[ 694, 6 ]

2

[]

0

true

Family

Protein of unknown function DUF4410

DUF4410

7

IPR025524

25,524

Domain of unknown function DUF4412

DUF4412

Domain

899

false

This presumed domain is functionally uncharacterised.

[]

0

[ "PFAM" ]

[ "PF14371" ]

[ "DUF4412" ]

[ 899 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Protostomia", "Stenosarchaea group", "ecological metagenomes" ]

[ 874, 2, 3, 20 ]

4

[]

0

true

Domain

Domain of unknown function DUF4412

DUF4412

6

IPR025525

25,525

hAT-like transposase, RNase-H fold

hAT-like_transposase_RNase-H

Domain

12,522

false

This domain is found as part of an RNase-H fold section in a number of hAT-like transposases, such as protein DAYSLEEPER (At3g42170) from Arabidopsis [ ]. Protein DAYSLEEPER is essential for plant development and can also regulate global gene expression [ ]. This entry also includes some uncharacterised fungal proteins...

[ "GO:0003677" ]

[ "DNA binding" ]

[ "molecular_function" ]

1

[ "PFAM" ]

[ "PF14372" ]

[ "hAT-like_RNase-H" ]

[ 12522 ]

1

[]

0

[]

0

[ "PUB00070967", "PUB00070969" ]

[ "24330683", "16015335" ]

[ "DAYSLEEPER: a nuclear and vesicular-localized protein that is expressed in proliferating tissues.", "An Arabidopsis hAT-like transposase is essential for plant development." ]

[ 2013, 2005 ]

2

[]

0

null

[ "Eukaryota" ]

[ 12522 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 73, 142, 58 ]

3

true

Domain

hAT-like transposase, RNase-H fold

hAT-like_transposase_RNase-H

4

IPR025526

25,526

DsrC-like domain superfamily

DsrC-like_dom_sf

Homologous_superfamily

5,963

false

The structure of DsrC, an archaeal homologue of the gamma subunit of dissimilatory sulphite reductase, consists of an orthogonal helical bundle with a β hairpin along one side [ ].

[]

0

[ "SSF" ]

[ "SSF69721" ]

[ "" ]

[ 5963 ]

1

[ "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC" ]

[ "2.8.1.-", "PWY-5303", "PWY-6675", "PWY-6892", "PWY-7250", "PWY-7887", "PWY-7888", "PWY-7889", "PWY-7891", "PWY-7892", "PWY-7904", "PWY-8164", "PWY-8179" ]

[ "EC:2.8.1.-", "METACYC:PWY-5303", "METACYC:PWY-6675", "METACYC:PWY-6892", "METACYC:PWY-7250", "METACYC:PWY-7887", "METACYC:PWY-7888", "METACYC:PWY-7889", "METACYC:PWY-7891", "METACYC:PWY-7892", "METACYC:PWY-7904", "METACYC:PWY-8164", "METACYC:PWY-8179" ]

13

[ "1ji8", "1sau", "1yx3", "2a5w", "2v4j", "2xsj", "3or1", "3or2", "7syb" ]

9

[ "PUB00019446" ]

[ "11722571" ]

[ "Solution structure of Pyrobaculum aerophilum DsrC, an archaeal homologue of the gamma subunit of dissimilatory sulfite reductase." ]

[ 2001 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Caudoviricetes", "Eukaryota", "unclassified sequences" ]

[ 39, 5691, 3, 8, 222 ]

5

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Homologous_superfamily

DsrC-like domain superfamily

DsrC-like_dom_sf

2

IPR025527

25,527

HUWE1/REV1, ubiquitin-binding motif

HUWE1/Rev1_UBM

Conserved_site

10,234

false

This entry contains repetitive elements (RE) from a subgroup of HECT E3 ubiquitin ligases and the Y-family translesion polymerases, including human HUWE1 and REV1. Each of these repetitive elements are approximately 20 amino acids in length and contain two predicted helical segments separated by a Leu-Pro motif. The RE...

[]

0

[ "PFAM" ]

[ "PF14377" ]

[ "UBM" ]

[ 10234 ]

1

[ "EC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "2.3.2.26", "PWY-7511", "R-GGA-353503", "R-HSA-110312", "R-HSA-5655862", "R-HSA-5656121", "R-HSA-5656169", "R-HSA-6798695", "R-HSA-983168", "R-MMU-110312", "R-MMU-5655862", "R-MMU-5656121", "R-MMU-5656169", "R-MMU-6798695", "R-MMU-983168", "R-SCE-6798695", "R-SCE-983168", "R-SPO-67...

[ "EC:2.3.2.26", "METACYC:PWY-7511", "REACTOME:R-GGA-353503", "REACTOME:R-HSA-110312", "REACTOME:R-HSA-5655862", "REACTOME:R-HSA-5656121", "REACTOME:R-HSA-5656169", "REACTOME:R-HSA-6798695", "REACTOME:R-HSA-983168", "REACTOME:R-MMU-110312", "REACTOME:R-MMU-5655862", "REACTOME:R-MMU-5656121", "...

19

[ "2khu", "2khw", "2ktf", "2kwu", "2kwv", "2l0f", "2l0g", "2mbb", "2mul", "3ai4", "5vzm", "6asr", "6axd", "7jq9", "7mop", "7mwd", "7mwe", "7mwf", "9dns", "9dnt", "9egk", "9eld", "9mhp" ]

23

[ "PUB00091009", "PUB00102678", "PUB00103302" ]

[ "26658142", "29864443", "34314700" ]

[ "The UVS9 gene of Chlamydomonas encodes an XPG homolog with a new conserved domain.", "Structures of REV1 UBM2 Domain Complex with Ubiquitin and with a Small-Molecule that Inhibits the REV1 UBM2-Ubiquitin Interaction.", "Solenoid architecture of HUWE1 contributes to ligase activity and substrate recognition." ]

[ 2016, 2018, 2021 ]

3

[]

0

null

[ "Eukaryota", "Gaeavirus sp." ]

[ 10233, 1 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 12, 8, 48, 7, 11, 14, 2, 5, 16, 1, 1, 71 ]

12

true

Conserved_site

HUWE1/REV1, ubiquitin-binding motif

HUWE1/Rev1_UBM

3

IPR025529

25,529

Protein of unknown function DUF4416

DUF4416

Family

686

false

This family of proteins is functionally uncharacterised. There is a conserved DPG sequence motif that may be important for function.

[]

0

[ "PFAM" ]

[ "PF14385" ]

[ "DUF4416" ]

[ 686 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "ecological metagenomes" ]

[ 629, 2, 55 ]

3

[]

0

true

Family

Protein of unknown function DUF4416

DUF4416

7

IPR025530

25,530

Protein of unknown function DUF4417

DUF4417

Family

669

false

This family of proteins is functionally uncharacterised. There is a single completely conserved glycine residue that may be functionally important.

[]

0

[ "PFAM" ]

[ "PF14386" ]

[ "DUF4417" ]

[ 669 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Candidatus Methanocrinis alkalitolerans", "Viruses", "Zophobas morio", "metagenomes" ]

[ 477, 2, 174, 1, 15 ]

5

[]

0

true

Family

Protein of unknown function DUF4417

DUF4417

5

IPR025531

25,531

Protein of unknown function DUF4418

DUF4418

Family

498

false

This family of proteins is functionally uncharacterised.

[]

0

[ "PFAM" ]

[ "PF14387" ]

[ "DUF4418" ]

[ 498 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Methanoregula boonei (strain DSM 21154 / JCM 14090 / 6A8)", "ecological metagenomes" ]

[ 491, 1, 6 ]

3

[]

0

true

Family

Protein of unknown function DUF4418

DUF4418

4

IPR025532

25,532

Glucose-6-phosphate 1-epimerase

G6P_1-epimerase

Family

12,545

false

Glucose-6-phosphate 1-epimerase ( ) has been shown to catalyse the interconversion between the alpha and beta anomers from at least three hexose 6-phosphate sugars (Glc6P, Gal6P, and Man6P) [ ].

[]

0

[ "PIRSF", "CDD" ]

[ "PIRSF016020", "cd09020" ]

[ "PHexose_mutarotase", "D-hex-6-P-epi_like" ]

[ 11411, 12166 ]

2

[ "EC" ]

[ "5.1.3.15" ]

[ "EC:5.1.3.15" ]

1

[ "1jov", "2ciq", "2cir", "2cis", "2hta", "2htb" ]

6

[ "PUB00047186" ]

[ "16857670" ]

[ "Structure-based functional annotation: yeast ymr099c codes for a D-hexose-6-phosphate mutarotase." ]

[ 2006 ]

1

[ "IPR008183" ]

[]

1

0

1

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 6124, 6377, 44 ]

3

[ "Arabidopsis thaliana", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Zea mays" ]

[ 31, 3, 1, 1, 18, 1, 26 ]

7

true

Family

Glucose-6-phosphate 1-epimerase

G6P_1-epimerase

7

IPR025533

25,533

Protein of unknown function DUF4419

DUF4419

Family

3,542

false

This family of proteins is functionally uncharacterised.

[]

0

[ "PFAM", "PANTHER" ]

[ "PF14388", "PTHR31252" ]

[ "DUF4419", "" ]

[ 3541, 3392 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Viruses", "metagenomes" ]

[ 352, 3141, 41, 8 ]

4

[]

0

true

Family

Protein of unknown function DUF4419

DUF4419

8

IPR025534

25,534

Putative PD-(D/E)XK family member (DUF4420)

DUF4420

Family

1,741

false

This family of proteins is functionally uncharacterised. This family of proteins is found in bacteria and archaea. Proteins in this family are typically between 310 and 334 amino acids in length. Advanced homology-detection methods supported with superfamily-wide domain architecture and horizontal gene transfer analyse...

[]

0

[ "PFAM" ]

[ "PF14390" ]

[ "DUF4420" ]

[ 1741 ]

1

[]

0

[]

0

[ "PUB00066699" ]

[ "22638584" ]

[ "Sequence, structure and functional diversity of PD-(D/E)XK phosphodiesterase superfamily." ]

[ 2012 ]

1

[]

[ "IPR049664" ]

0

1

0

[ "Bacteria", "Methanobacteriota", "unclassified sequences" ]

[ 1708, 10, 23 ]

3

[]

0

true

Family

Putative PD-(D/E)XK family member (DUF4420)

DUF4420

6

IPR025535

25,535

Protein of unknown function DUF4421

DUF4421

Family

1,301

false

This family of proteins is functionally uncharacterised.

[]

0

[ "PFAM" ]

[ "PF14391" ]

[ "DUF4421" ]

[ 1301 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Opisthokonta", "metagenomes" ]

[ 1293, 2, 6 ]

3

[]

0

true

Family

Protein of unknown function DUF4421

DUF4421

6

IPR025536

25,536

Domain of unknown function DUF4422

DUF4422

Domain

2,019

false

The function of this domain is not known.

[]

0

[ "PFAM" ]

[ "PF14393" ]

[ "DUF4422" ]

[ 2019 ]

1

[]

0

[ "6u4b" ]

1

[]

0

[]

0

null

[ "Bacteria", "Caudoviricetes", "Eukaryota", "Methanobacteriati", "metagenomes" ]

[ 1980, 5, 3, 13, 18 ]

5

[]

0

true

Domain

Domain of unknown function DUF4422

DUF4422

5

IPR025537

25,537

Domain of unknown function DUF4423

DUF4423

Domain

398

false

This presumed domain is functionally uncharacterised.

[]

0

[ "PFAM" ]

[ "PF14394" ]

[ "DUF4423" ]

[ 398 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Sphagnum jensenii", "uncultured microorganism" ]

[ 395, 1, 2 ]

3

[]

0

true

Domain

Domain of unknown function DUF4423

DUF4423

4

IPR025538

25,538

Domain of unknown function DUF4424

DUF4424

Domain

1,071

false

This is a domain of unknown function is found in bacterial proteins.

[]

0

[ "PFAM" ]

[ "PF14415" ]

[ "DUF4424" ]

[ 1071 ]

1

[]

0

[ "4g2a" ]

1

[]

0

[]

0

null

[ "Bacteria", "ecological metagenomes" ]

[ 1067, 4 ]

2

[]

0

true

Domain

Domain of unknown function DUF4424

DUF4424

8

IPR025539

25,539

YdgH protein

YdgH

Family

1,231

false

This family of uncharacterised proteins is found in Enterobacteria.

[]

0

[ "NCBIFAM", "PIRSF" ]

[ "NF040471", "PIRSF014774" ]

[ "ydgH_STM1478", "YdgH" ]

[ 1231, 849 ]

2

[]

0

[]

0

[ "PUB00097759" ]

[ "25010333" ]

[ "Structural and functional characterization of DUF1471 domains of Salmonella proteins SrfN, YdgH/SssB, and YahO." ]

[ 2014 ]

1

[]

0

null

[ "Bacteria", "Beauveria bassiana D1-5" ]

[ 1230, 1 ]

2

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

YdgH protein

YdgH

4

IPR025540

25,540

Fluoroacetyl-CoA thioesterase

FlK

Family

4,223

false

This family of fluoroacetyl-CoA thioesterases includes FlK from the fluoroacetate-producing Streptomyces cattleya. FlK selectively hydrolyses fluoroacetyl-CoA over acetyl-CoA. It has been suggested that FlK protects its host from fluoroacetate toxicity [ , ].

[]

0

[ "PIRSF", "PANTHER" ]

[ "PIRSF014972", "PTHR36934" ]

[ "FlK", "" ]

[ 3272, 4223 ]

2

[]

0

[ "2cwz", "2q78", "3kuv", "3kuw", "3kv7", "3kv8", "3kvi", "3kvu", "3kvz", "3kw1", "3kx7", "3kx8", "3p2q", "3p2r", "3p2s", "3p3f", "3p3i", "3qoo" ]

18

[ "PUB00057360", "PUB00057361" ]

[ "20836570", "16720268" ]

[ "Structural and biochemical studies of a fluoroacetyl-CoA-specific thioesterase reveal a molecular basis for fluorine selectivity.", "The gene cluster for fluorometabolite biosynthesis in Streptomyces cattleya: a thioesterase confers resistance to fluoroacetyl-coenzyme A." ]

[ 2010, 2006 ]

2

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "metagenomes" ]

[ 104, 3844, 92, 183 ]

4

[]

0

true

Family

Fluoroacetyl-CoA thioesterase

FlK

6

IPR025541

25,541

Propanediol/glycerol dehydratase, medium subunit

Ppandiol/glycerol_DHydtase_msu

Family

1,350

false

Diol dehydratase ( ) and glycerol dehydratase ( ) are two iso-functional enzymes that can each catalyse the conversion of 1,2-propanediol, 1,2-ethanediol and glycerol to the corresponding deoxy aldehydes (propionaldehyde, acetaldehyde and 3-hydroxypropionaldehyde, respectively). This reaction proceeds by a radical mech...

[]

0

[ "NCBIFAM", "PIRSF" ]

[ "NF011616", "PIRSF018506" ]

[ "PRK15042.1", "Prpndl_dhdrts_md" ]

[ 1350, 1177 ]

2

[]

0

[ "1dio", "1eex", "1egm", "1egv", "1iwb", "1iwp", "1mmf", "1uc4", "1uc5", "3auj", "5yrt", "5yrv", "5ysh", "7xrk", "7xrl" ]

15

[ "PUB00011184", "PUB00013627", "PUB00013628", "PUB00013629", "PUB00013630", "PUB00069745", "PUB00100250" ]

[ "10498708", "1267798", "210157", "12230560", "10949584", "21040475", "28475631" ]

[ "The propanediol utilization (pdu) operon of Salmonella enterica serovar Typhimurium LT2 includes genes necessary for formation of polyhedral organelles involved in coenzyme B(12)-dependent 1, 2-propanediol degradation.", "Substrate specificity of coenzyme B12-dependent diol dehydrase: glycerol as both a good sub...

[ 1999, 1976, 1978, 2002, 2000, 2010, 2017 ]

7

[ "IPR003208" ]

[]

1

0

1

[ "Bacteria", "Halobacteriales", "bioreactor metagenome" ]

[ 1337, 11, 2 ]

3

[]

0

true

Family

Propanediol/glycerol dehydratase, medium subunit

Ppandiol/glycerol_DHydtase_msu

1

IPR025542

25,542

YacH protein

YacH

Family

3,260

false

The proteins in this family contain one UVR domain and are functionally uncharacterised. This family includes the YacH protein from Bacillus subtilis.

[]

0

[ "PIRSF", "PANTHER" ]

[ "PIRSF015034", "PTHR38430" ]

[ "YacH", "" ]

[ 3092, 3260 ]

2

[]

0

[ "8gqd", "8wtb", "8wtc" ]

3

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Thermococcus litoralis", "metagenomes" ]

[ 3202, 3, 1, 54 ]

4

[]

0

true

Family

YacH protein

YacH

1

IPR025543

25,543

Dodecin-like

Homologous_superfamily

19,407

false

Dodecin flavoprotein is a small dodecameric flavin-binding protein from Halobacterium salinarium that contains two flavins stacked in a single binding pocket between two tryptophan residues to form an aromatic tetrade [ ]. This entry represents Dodecin and structurally related proteins, including the functionally uncha...

[]

0

[ "CATHGENE3D" ]

[ "G3DSA:3.30.1660.10" ]

[ "" ]

[ 19407 ]

1

[]

0

[ "1mog", "2cc6", "2cc7", "2cc8", "2cc9", "2ccb", "2ccc", "2cie", "2cif", "2cjc", "2cz8", "2deg", "2deh", "2dev", "2jna", "2m2j", "2ma4", "2ma8", "2noc", "2ux9", "2v18", "2v19", "2v21", "2vkf", "2vkg", "2vx9", "2vxa", "2vyx", "2yiz", "2yj0", "3onr", "3oqt"...

39

[ "PUB00035544" ]

[ "16460756" ]

[ "Dodecins: a family of lumichrome binding proteins." ]

[ 2006 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Chimalliviridae", "Opisthokonta", "unclassified sequences" ]

[ 451, 18793, 15, 19, 129 ]

5

[ "Escherichia coli (strain K12)" ]

[ 10 ]

1

true

Homologous_superfamily

Dodecin-like

7

IPR025544

25,544

YhzD-like protein

YhzD

Family

928

false

This family, named for the Bacillus subtilis YhzD protein, is functionally uncharacterised. Proteins in this family contain a conserved GKL sequence motif.

[]

0

[ "PFAM" ]

[ "PF14120" ]

[ "YhzD" ]

[ 928 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacilli", "unclassified sequences" ]

[ 926, 2 ]

2

[]

0

true

Family

YhzD-like protein

YhzD

3

IPR025545

25,545

YozD-like protein

YozD

Family

406

false

The YozD-like protein family includes the B. subtilis YozD protein , which is functionally uncharacterised.

[]

0

[ "PFAM" ]

[ "PF14162" ]

[ "YozD" ]

[ 406 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacillales", "uncultured Caudovirales phage" ]

[ 405, 1 ]

2

[]

0

true

Family

YozD-like protein

YozD

4

IPR025546

25,546

YqzH-like protein

YqzH

Family

380

false

The YqzH-like protein family includes the B. subtilis YqzH protein , which is functionally uncharacterised.

[]

0

[ "PFAM" ]

[ "PF14164" ]

[ "YqzH" ]

[ 380 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacillales" ]

[ 380 ]

1

[]

0

true

Family

YqzH-like protein

YqzH

1

IPR025547

25,547

YtzH-like protein

YtzH

Family

693

false

The YtzH-like protein family includes the B. subtilis YtzH protein , which is functionally uncharacterised. Proteins in this family are approximately 90 amino acids in length and contain a conserved DIL sequence motif.

[]

0

[ "PFAM" ]

[ "PF14165" ]

[ "YtzH" ]

[ 693 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacillales", "Batrachochytrium dendrobatidis (strain JAM81 / FGSC 10211)" ]

[ 692, 1 ]

2

[]

0

true

Family

YtzH-like protein

YtzH

9

IPR025548

25,548

YfkD-like protein

YfkD

Family

821

false

The YfkD-like protein family includes the B. subtilis YfkD protein , which is functionally uncharacterised. Its expression is regulated by the sigma factor sigma-B, which regulates the expression of stress-response proteins, and by the forespore-specific sigma factor sigma-G [ , ].

[]

0

[ "PFAM" ]

[ "PF14167" ]

[ "YfkD" ]

[ 821 ]

1

[]

0

[]

0

[ "PUB00034417", "PUB00057363" ]

[ "12480901", "19543710" ]

[ "Proteomics characterization of novel spore proteins of Bacillus subtilis.", "Characterization of Bacillus subtilis YfkE (ChaA): a calcium-specific Ca2+/H+ antiporter of the CaCA family." ]

[ 2002, 2009 ]

2

[]

0

null

[ "Bacillota" ]

[ 821 ]

1

[]

0

true

Family

YfkD-like protein

YfkD

9

IPR025549

25,549

YjzC-like protein

YjzC

Family

1,330

false

The YjzC-like protein family includes the B. subtilis YjzC protein , which is functionally uncharacterised.

[]

0

[ "PFAM" ]

[ "PF14168" ]

[ "YjzC" ]

[ 1330 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Methanococcus maripaludis KA1", "ecological metagenomes", "unclassified Caudoviricetes" ]

[ 1319, 1, 4, 6 ]

4

[]

0

true

Family

YjzC-like protein

YjzC

6

IPR025551

25,551

Immunity protein WapI/YxiJ-like

WapI/YxiJ-like

Family

314

false

This is a family of immunity proteins, mainly from Bacillus spp, such as WapI. The immunity protein WapI specifically neutralizes its cognate toxin WapA to protect wapA+ cells from autoinhibition. WapA carries a C-terminal toxin domain (WapA-CT) that inhibits the growth of neighbouring cells [ ].

[]

0

[ "PFAM" ]

[ "PF14176" ]

[ "YxiJ" ]

[ 314 ]

1

[]

0

[]

0

[ "PUB00088067" ]

[ "23572593" ]

[ "Rhs proteins from diverse bacteria mediate intercellular competition." ]

[ 2013 ]

1

[]

0

null

[ "Bacillati" ]

[ 314 ]

1

[]

0

true

Family

Immunity protein WapI/YxiJ-like

WapI/YxiJ-like

9

IPR025552

25,552

YkyB-like protein

YkyB

Family

841

false

The YkyB-like protein family includes the B. subtilis YkyB protein , which is functionally uncharacterised. Proteins in this family are approximately 150 amino acids in length and contain two conserved sequence motifs: NRHAKTA and HLG.

[]

0

[ "PFAM" ]

[ "PF14177" ]

[ "YkyB" ]

[ 841 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacillota" ]

[ 841 ]

1

[]

0

true

Family

YkyB-like protein

YkyB

7

IPR025554

25,554

Domain of unknown function DUF4140

DUF4140

Domain

5,452

false

This N-terminal domain of unknown function is often found with DUF4139 ( ).

[]

0

[ "PFAM" ]

[ "PF13600" ]

[ "DUF4140" ]

[ 5452 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "ecological metagenomes" ]

[ 15, 3285, 2128, 24 ]

4

[ "Caenorhabditis elegans" ]

[ 6 ]

1

true

Domain

Domain of unknown function DUF4140

DUF4140

5

IPR025555

25,555

YppG-like protein

YppG

Family

935

false

The YppG-like protein family includes the B. subtilis YppG protein , which is functionally uncharacterised. Proteins in this family are typically between 115 and 181 amino acids in length and contain two completely conserved residues (F and G) that may be functionally important.

[]

0

[ "PFAM" ]

[ "PF14179" ]

[ "YppG" ]

[ 935 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacillales" ]

[ 935 ]

1

[]

0

true

Family

YppG-like protein

YppG

8

IPR025557

25,557

Protein of unknown function DUF4282

DUF4282

Family

1,813

false

This family of proteins is functionally uncharacterised. Proteins in this family contain is a single completely conserved residue E that may be functionally important.

[]

0

[ "PFAM" ]

[ "PF14110" ]

[ "DUF4282" ]

[ 1813 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Edwardsiella phage GF-2", "Eukaryota", "ecological metagenomes" ]

[ 1776, 1, 13, 23 ]

4

[]

0

true

Family

Protein of unknown function DUF4282

DUF4282

3

IPR025558

25,558

Domain of unknown function DUF4283

DUF4283

Domain

27,331

false

This domain is found in a group of uncharacterised plant proteins. Considering the very diverse range of other domains it is associated with, it is possible that this domain is a binding/guiding region. It contains two highly conserved tryptophan residues.

[]

0

[ "PFAM" ]

[ "PF14111" ]

[ "DUF4283" ]

[ 27331 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Eukaryota" ]

[ 27331 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 218, 28, 1 ]

3

true

Domain

Domain of unknown function DUF4283

DUF4283

4

IPR025559

25,559

Enhanced intracellular survival protein domain

Eis_dom

Domain

9,433

false

This domain is found in enhanced intracellular survival protein eis from Mycobacterium tuberculosis. It shares protein sequence similarity with the SCP2 sterol-binding domain.

[]

0

[ "PFAM" ]

[ "PF13530" ]

[ "SCP2_2" ]

[ 9433 ]

1

[ "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC"...

[ "2.3.1.-", "PWY-3602", "PWY-361", "PWY-4801", "PWY-4922", "PWY-5048", "PWY-5139", "PWY-5268", "PWY-5284", "PWY-5292", "PWY-5307", "PWY-5313", "PWY-5317", "PWY-5318", "PWY-5353", "PWY-5400", "PWY-5473", "PWY-5475", "PWY-5477", "PWY-5660", "PWY-5679", "PWY-5710", "PWY-5794"...

[ "EC:2.3.1.-", "METACYC:PWY-3602", "METACYC:PWY-361", "METACYC:PWY-4801", "METACYC:PWY-4922", "METACYC:PWY-5048", "METACYC:PWY-5139", "METACYC:PWY-5268", "METACYC:PWY-5284", "METACYC:PWY-5292", "METACYC:PWY-5307", "METACYC:PWY-5313", "METACYC:PWY-5317", "METACYC:PWY-5318", "METACYC:PWY-53...

220

[ "2hv2", "2i00", "2ozg", "3n7z", "3r1k", "3ryo", "3sxn", "3sxo", "3uy5", "4jd6", "4my0", "4my3", "4qb9", "5ebv", "5ec4", "5iv0", "5tvj", "6b0u", "6b3t", "6p3t", "6p3u", "6p3v", "6rft", "6rfx", "6rfy", "6vur", "6vus", "6vut", "6vuu", "6vuw", "6vux", "6vuy"...

56

[ "PUB00013599" ]

[ "10629183" ]

[ "Identification of a Mycobacterium tuberculosis gene that enhances mycobacterial survival in macrophages." ]

[ 2000 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "metagenomes" ]

[ 236, 9129, 6, 62 ]

4

[]

0

true

Domain

Enhanced intracellular survival protein domain

Eis_dom

1

IPR025560

25,560

Immunity protein 22

Imm22

Family

1,005

false

This entry represents a predicted immunity protein with an α+β fold and conserved tryptophan,tyrosine and an acidic residues. Proteins containing this domain are present in bacterial polymorphic toxin systems as an immediate gene neighbour of the toxin gene, which usually contains toxin domains of the ColD/E5, Tox-REas...

[]

0

[ "PFAM" ]

[ "PF14112" ]

[ "DUF4284" ]

[ 1005 ]

1

[]

0

[]

0

[ "PUB00066726" ]

[ "22731697" ]

[ "Polymorphic toxin systems: Comprehensive characterization of trafficking modes, processing, mechanisms of action, immunity and ecology using comparative genomics." ]

[ 2012 ]

1

[]

0

null

[ "Bacteria", "Fungi", "metagenomes" ]

[ 1001, 2, 2 ]

3

[]

0

true

Family

Immunity protein 22

Imm22

3

IPR025561

25,561

Kinase suppressor of RAS, SAM-like domain

KSR_SAM-like_dom

Domain

1,058

false

This SAM-like domain is found in kinase suppressor of Ras proteins, which are location-regulated scaffolding proteins connecting MEK to RAF [ ]. This domain is part of the N-terminal regulatory region that mediates heterodimerization of BRAF with KSR1.

[]

0

[ "PFAM" ]

[ "PF13543" ]

[ "SAM_KSR1" ]

[ 1058 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-5674135", "R-HSA-6802946", "R-HSA-6802948", "R-HSA-6802952", "R-HSA-6802955", "R-HSA-9649948", "R-HSA-9656223", "R-MMU-5674135" ]

[ "REACTOME:R-HSA-5674135", "REACTOME:R-HSA-6802946", "REACTOME:R-HSA-6802948", "REACTOME:R-HSA-6802952", "REACTOME:R-HSA-6802955", "REACTOME:R-HSA-9649948", "REACTOME:R-HSA-9656223", "REACTOME:R-MMU-5674135" ]

8

[]

0

[ "PUB00101264" ]

[ "29433126" ]

[ "MEK drives BRAF activation through allosteric control of KSR proteins." ]

[ 2018 ]

1

[]

0

null

[ "Eumetazoa" ]

[ 1058 ]

1

[ "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 7, 1, 4, 1 ]

4

true

Domain

Kinase suppressor of RAS, SAM-like domain

KSR_SAM-like_dom

5

IPR025562

25,562

Type VI secretion system (T6SS), amidase effector protein 4

Tae4

Family

1,743

false

Tae4 is a new form of toxin-antitoxin system protein for a type VI secretion system, T6SS. T6SS has roles in interspecies interactions, as well as higher order host-infection, by injecting effector proteins into the periplasmic compartment of the recipient cells of closely related species. Pseudomonas aeruginosa produc...

[]

0

[ "PFAM" ]

[ "PF14113" ]

[ "Tae4" ]

[ 1743 ]

1

[]

0

[ "4bi3", "4bi4", "4bi8", "4hff", "4hfk", "4hfl", "4j30", "4j32", "4jur", "6ijf" ]

10

[ "PUB00075621" ]

[ "23288853" ]

[ "Structure of the type VI effector-immunity complex (Tae4-Tai4) provides novel insights into the inhibition mechanism of the effector by its immunity protein." ]

[ 2013 ]

1

[]

0

null

[ "Bacteria", "Burkholderia phage ST79", "Eukaryota", "metagenomes" ]

[ 1669, 1, 59, 14 ]

4

[]

0

true

Family

Type VI secretion system (T6SS), amidase effector protein 4

Tae4

8

IPR025563

25,563

Protein of unknown function DUF4286

DUF4286

Family

2,612

false

This family of proteins is functionally uncharacterised.

[]

0

[ "PFAM" ]

[ "PF14114" ]

[ "DUF4286" ]

[ 2612 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Methanobacteriati", "Myoviridae sp. ctcPl3", "metagenomes" ]

[ 2456, 107, 10, 1, 38 ]

5

[]

0

true

Family

Protein of unknown function DUF4286

DUF4286

8

IPR025564

25,564

Cyanobacterial aminoacyl-tRNA synthetase, CAAD domain

CAAD_dom

Domain

3,987

false

This domain is present in aminoacyl-tRNA synthetases (aaRSs), enzymes that couple tRNAs to their cognate amino acids [ ]. aaRSs from cyanobacteria containing the CAAD (for cyanobacterial aminoacyl-tRNA synthetases appended domain) protein domains are localised in the thylakoid membrane. The domain bears two putative tr...

[]

0

[ "PFAM" ]

[ "PF14159" ]

[ "CAAD" ]

[ 3987 ]

1

[]

0

[]

0

[ "PUB00066703" ]

[ "18775898" ]

[ "Intraphylum diversity and complex evolution of cyanobacterial aminoacyl-tRNA synthetases." ]

[ 2008 ]

1

[]

0

null

[ "Bacillati", "Eukaryota" ]

[ 754, 3233 ]

2

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 15, 22, 45 ]

3

true

Domain

Cyanobacterial aminoacyl-tRNA synthetase, CAAD domain

CAAD_dom

8

IPR025565

25,565

Domain of unknown function DUF4328

DUF4328

Domain

3,353

false

This domain is functionally uncharacterised. It is found in proteins from bacteria.

[]

0

[ "PFAM" ]

[ "PF14219" ]

[ "DUF4328" ]

[ 3353 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Diploscapter pachys", "ecological metagenomes" ]

[ 3323, 2, 28 ]

3

[]

0

true

Domain

Domain of unknown function DUF4328

DUF4328

3

IPR025566

25,566

Protein of unknown function DUF4331

DUF4331

Family

3,721

false

This family of bacterial proteins is functionally uncharacterised. Proteins in this family contain a conserved FPY sequence motif.

[]

0

[ "PFAM" ]

[ "PF14224" ]

[ "DUF4331" ]

[ 3721 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 3696, 4, 21 ]

3

[]

0

true

Family

Protein of unknown function DUF4331

DUF4331

9

IPR025567

25,567

Domain of unknown function DUF4332

DUF4332

Domain

1,636

false

This presumed domain of unknown function is sometimes found on its own in uncharacterised bacterial proteins, and can also be found at the C terminus of Lysine-tRNA ligases and other proteins.

[]

0

[ "PFAM" ]

[ "PF14229" ]

[ "DUF4332" ]

[ 1636 ]

1

[ "EC" ]

[ "6.1.1.6" ]

[ "EC:6.1.1.6" ]

1

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 26, 1545, 12, 53 ]

4

[]

0

true

Domain

Domain of unknown function DUF4332

DUF4332

7

IPR025568

25,568

Domain of unknown function DUF4334

DUF4334

Domain

2,145

false

This domain is found in bacteria and eukaryotes, and is approximately 60 amino acids in length. This domain is frequently found at the C terminus of .

[]

0

[ "PFAM" ]

[ "PF14232" ]

[ "DUF4334" ]

[ 2145 ]

1

[]

0

[ "4mve" ]

1

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "ecological metagenomes" ]

[ 1721, 421, 3 ]

3

[]

0

true

Domain

Domain of unknown function DUF4334

DUF4334

1

IPR025569

25,569

Protein of unknown function DUF4335

DUF4335

Family

644

false

This family of proteins is functionally uncharacterised. Proteins in this family acontain two completely conserved residues (G and D) that may be functionally important.

[]

0

[ "PFAM" ]

[ "PF14233" ]

[ "DUF4335" ]

[ 644 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Cyanobacteriota", "Eukaryota" ]

[ 639, 5 ]

2

[]

0

true

Family

Protein of unknown function DUF4335

DUF4335

4

IPR025571

25,571

YqfQ-like protein

YqfQ

Family

1,004

false

The YqfQ-like protein family includes the B. subtilis YqfQ protein , also known as VrrA, which is functionally uncharacterised. Proteins in this family are typically between 146 and 237 amino acids in length and contain two conserved sequence motifs: QYGP and PKLY.

[]

0

[ "PFAM" ]

[ "PF14181" ]

[ "YqfQ" ]

[ 1004 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacillati" ]

[ 1004 ]

1

[]

0

true

Family

YqfQ-like protein

YqfQ

9

IPR025572

25,572

YgaB-like protein

YgaB

Family

478

false

The YgaB-like protein family includes the B. subtilis YgaB protein , which is functionally uncharacterised.

[]

0

[ "PFAM" ]

[ "PF14182" ]

[ "YgaB" ]

[ 478 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacillota" ]

[ 478 ]

1

[]

0

true

Family

YgaB-like protein

YgaB

5

IPR025573

25,573

YwpF-like protein

YwpF

Family

946

false

The YwpF-like protein family includes the B. subtilis YwpF protein , which is functionally uncharacterised. Proteins in this family are typically between 146 and 167 amino acids in length and contain a conserved IIN sequence motif.

[]

0

[ "PFAM" ]

[ "PF14183" ]

[ "YwpF" ]

[ 946 ]

1

[]

0

[ "4qxz" ]

1

[]

0

[]

0

null

[ "Acyrthosiphon pisum", "Bacteria" ]

[ 1, 945 ]

2

[]

0

true

Family

YwpF-like protein

YwpF

1

IPR025575

25,575

DpnD/PcfM-like, C-terminal domain

DpnD/PcfM_C

Domain

522

false

This entry represents a presumed domain found at the C-terminal of a group of functionally uncharacterised proteins from bacteria. There are two completely conserved residues (E and A) that may be functionally important.

[]

0

[ "PFAM" ]

[ "PF14207" ]

[ "DpnD-PcfM" ]

[ 522 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Viruses", "metagenomes" ]

[ 496, 7, 19 ]

3

[]

0

true

Domain

DpnD/PcfM-like, C-terminal domain

DpnD/PcfM_C

3

IPR025576

25,576

YwiC-like protein

YwiC

Family

1,785

false

The YwiC-like protein family includes the B. subtilis YwiC protein , which is functionally uncharacterised. There is a single completely conserved residue G that may be functionally important.

[]

0

[ "PFAM" ]

[ "PF14256" ]

[ "YwiC" ]

[ 1785 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "unclassified sequences" ]

[ 1774, 11 ]

2

[]

0

true

Family

YwiC-like protein

YwiC

1

IPR025577

25,577

FlxA-like protein

FlxA

Family

1,262

false

This family includes FlxA from E. coli ( ) and related sequences. The expression of FlxA is regulated by the FliA sigma factor, a transcription factor specific for class 3 flagellar operons. However FlxA is not required for flagellar function or formation [ ].

[]

0

[ "PFAM" ]

[ "PF14282" ]

[ "FlxA" ]

[ 1262 ]

1

[]

0

[]

0

[ "PUB00057365" ]

[ "9358034" ]

[ "Identification of a novel Escherichia coli gene whose expression is dependent on the flagellum-specific sigma factor, FliA, but dispensable for motility development." ]

[ 1997 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 1241, 12, 9 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

FlxA-like protein

FlxA

6

IPR025578

25,578

Protein of unknown function DUF4359

DUF4359

Family

603

false

This family of bacterial proteins is functionally uncharacterised. Proteins in this family contain two completely conserved residues (P and S) that may be functionally important.

[]

0

[ "PFAM" ]

[ "PF14271" ]

[ "DUF4359" ]

[ 603 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria" ]

[ 603 ]

1

[]

0

true

Family

Protein of unknown function DUF4359

DUF4359

9

IPR025579

25,579

Domain of unknown function DUF4357

DUF4357

Domain

2,232

false

This domain is found in bacteria and archaea. In this domain there are two completely conserved residues (G and W) that may be functionally important.

[]

0

[ "PFAM" ]

[ "PF14267" ]

[ "DUF4357" ]

[ 2232 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Methanobacteriota", "Myoviridae sp. ctiil21", "unclassified sequences" ]

[ 2189, 23, 1, 19 ]

4

[]

0

true

Domain

Domain of unknown function DUF4357

DUF4357

2

IPR025580

25,580

Capsid assembly scaffolding protein Gp46

Gp46

Family

1,853

false

This entry includes the capsid assembly scaffolding protein Gp46 from Staphylococcus phage 80alpha, which is involved in icosahedric procapsid assembly. It coassembles with capsid proteins to form the procapsid [ ]. The scaffolding protein is found within the capsid as a series of concentric shells. During DNA packagin...

[]

0

[ "PFAM" ]

[ "PF14265" ]

[ "DUF4355" ]

[ 1853 ]

1

[]

0

[ "6b0x" ]

1

[ "PUB00153369" ]

[ "28984245" ]

[ "Competing scaffolding proteins determine capsid size during mobilization of <i>Staphylococcus aureus</i> pathogenicity islands." ]

[ 2017 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "Viruses", "metagenomes" ]

[ 1508, 6, 329, 10 ]

4

[]

0

true

Family

Capsid assembly scaffolding protein Gp46

Gp46

1

IPR025581

25,581

Protein of unknown function DUF4354

DUF4354

Family

142

false

Several members of this family are annotated as being ATP/GTP-binding site motif A (P-loop) proteins, but this has not been confirmed. The one structure solved for this family ( ) exhibits an immunoglobin-like β-sandwich fold. Crystal packing suggests that a tetramer is a significant oligomerisation state, and a disulp...

[]

0

[ "PFAM" ]

[ "PF14263" ]

[ "DUF4354" ]

[ 142 ]

1

[]

0

[ "3nrf", "3sb3" ]

2

[]

0

[]

0

null

[ "Pseudomonadota" ]

[ 142 ]

1

[]

0

true

Family

Protein of unknown function DUF4354

DUF4354

7

IPR025582

25,582

YARHG domain

YARHG_dom

Domain

2,669

false

This presumed extracellular domain is about 70 amino acids in length. It is named YARHG after a conserved motif in the sequence. This domain is associated with peptidases and bacterial kinase proteins. Its molecular function is unknown.

[]

0

[ "PFAM", "SMART" ]

[ "PF13308", "SM01324" ]

[ "YARHG", "YARHG" ]

[ 2656, 2623 ]

2

[]

0

[ "4g2a" ]

1

[]

0

[]

0

null

[ "Bacteria", "Candidatus Methanofastidiosum methylothiophilum", "Notodromas monacha", "metagenomes" ]

[ 2660, 1, 1, 7 ]

4

[]

0

true

Domain

YARHG domain

YARHG_dom

2

IPR025583

25,583

HMG-CoA reductase, N-terminal domain

HMG-CoA_N_dom

Domain

1,391

false

This domain is found at the N terminus of fungal 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase, which catalyses the conversion of HMG-CoA to mevalonate. There is a well-conserved characteristic HPIH motif, but the function of the domain is not known.

[]

0

[ "PFAM" ]

[ "PF13323" ]

[ "HPIH" ]

[ 1391 ]

1

[ "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "REACTOME" ]

[ "1.1.1.34", "PWY-6174", "PWY-7391", "PWY-7524", "PWY-8125", "PWY-922", "R-SCE-191273" ]

[ "EC:1.1.1.34", "METACYC:PWY-6174", "METACYC:PWY-7391", "METACYC:PWY-7524", "METACYC:PWY-8125", "METACYC:PWY-922", "REACTOME:R-SCE-191273" ]

7

[]

0

[]

0

[]

0

null

[ "Mariniflexile litorale", "Opisthokonta" ]

[ 1, 1390 ]

2

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)" ]

[ 1, 2 ]

2

true

Domain

HMG-CoA reductase, N-terminal domain

HMG-CoA_N_dom

8

IPR025584

25,584

Carbohydrate-binding domain-containing protein Cthe_2159

Cthe_2159

Family

2,456

false

Cthe_2159 from Clostridium thermocellum is the first representative of a novel family of cellulose and/or acid-sugar binding β-helix proteins that share structural similarities with polysaccharide lyases [ ].

[]

0

[ "PFAM" ]

[ "PF14262" ]

[ "Cthe_2159" ]

[ 2456 ]

1

[]

0

[ "4peu", "4phb" ]

2

[ "PUB00076696" ]

[ "25286843" ]

[ "A new family of β-helix proteins with similarities to the polysaccharide lyases." ]

[ 2014 ]

1

[]

0

null

[ "Bacteria", "Buhlduvirus", "Eukaryota", "Methanobacteriota", "unclassified sequences" ]

[ 2361, 2, 51, 13, 29 ]

5

[]

0

true

Family

Carbohydrate-binding domain-containing protein Cthe_2159

Cthe_2159

5

IPR025585

25,585

Photosystem II Psb27

PSII_Psb27

Family

1,807

false

This entry represents Psb27, a small thylakoid lumen-localised protein known to serve as an assembly factor for the biogenesis and repair of the PSII complex [ ]. Psb27 is comprised of four helices arranged in a right handed up-down-up-down fold, with a less ordered region located at the N-terminal [ ].

[ "GO:0010206", "GO:0010207", "GO:0009523" ]

[ "photosystem II repair", "photosystem II assembly", "photosystem II" ]

[ "biological_process", "biological_process", "cellular_component" ]

3

[ "HAMAP", "PFAM", "PANTHER" ]

[ "MF_01481", "PF13326", "PTHR34041" ]

[ "PSII_Psb27", "PSII_Pbs27", "" ]

[ 1688, 1804, 1727 ]

3

[]

0

[ "2kmf", "2knd", "2y6x", "5x56", "6kac", "7czl", "7nhp", "8r2i" ]

8

[ "PUB00052696", "PUB00097451" ]

[ "19697958", "33495333" ]

[ "Solution structure of Psb27 from cyanobacterial photosystem II .", "Structural insights into a dimeric Psb27-photosystem II complex from a cyanobacterium <i>Thermosynechococcus vulcanus</i>." ]

[ 2009, 2021 ]

2

[]

[ "IPR017488" ]

0

1

0

[ "Bacillati", "Eukaryota" ]

[ 359, 1448 ]

2

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 8, 6, 9 ]

3

true

Family

Photosystem II Psb27

PSII_Psb27

2

IPR025586

25,586

PcfJ-like protein

PcfJ

Family

2,675

false

The PcfJ-like protein family includes the E. faecalis PcfJ protein , which is functionally uncharacterised. There is a conserved HCV sequence motif.

[]

0

[ "PFAM" ]

[ "PF14284" ]

[ "PcfJ" ]

[ 2675 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Viruses", "metagenomes" ]

[ 2391, 254, 30 ]

3

[]

0

true

Family

PcfJ-like protein

PcfJ

4

IPR025587

25,587

Domain of unknown function DUF4351

DUF4351

Domain

4,573

false

This uncharacterised domain is found in bacteria.

[]

0

[ "PFAM" ]

[ "PF14261" ]

[ "DUF4351" ]

[ 4573 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Methanomicrobiales", "unclassified sequences" ]

[ 4552, 3, 18 ]

3

[]

0

true

Domain

Domain of unknown function DUF4351

DUF4351

3

IPR025588

25,588

YcxB-like, C-terminal domain

YcxB-like_C

Domain

4,518

false

This entry represents the C-terminal domain of the B. subtilis YcxB protein , which is a functionally uncharacterised transmembrane protein, and similar bacterial sequences.

[]

0

[ "PFAM" ]

[ "PF14317" ]

[ "YcxB" ]

[ 4518 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Beauveria bassiana D1-5", "Methanomicrobia", "metagenomes" ]

[ 4475, 1, 4, 38 ]

4

[]

0

true

Domain

YcxB-like, C-terminal domain

YcxB-like_C

7

IPR025589

25,589

Topoisomerase C-terminal repeat

Toprim_C_rpt

Repeat

20,362

false

This domain occurs in the C terminus of a number of DNA topoisomerases 1. It is sometimes found repeated.

[]

0

[ "PFAM", "PFAM" ]

[ "PF13342", "PF13368" ]

[ "Toprim_Crpt", "Toprim_C_rpt" ]

[ 7245, 13117 ]

2

[ "EC" ]

[ "5.6.2.1" ]

[ "EC:5.6.2.1" ]

1

[ "6pcm" ]

1

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 12, 18889, 923, 45, 493 ]

5

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 9, 4, 23 ]

3

true

Repeat

Topoisomerase C-terminal repeat

Toprim_C_rpt

9

IPR025591

25,591

RloB-like protein

RloB

Family

3,086

false

This family includes the RloB protein that is found within a bacterial restriction modification operon. It also includes the AbiLii protein that is found as part of a plasmid encoded phage abortive infection mechanism [ ]. Deletion of part of the abiLii gene was sufficient to abolish phage resistance. Other proteins in...

[]

0

[ "PFAM" ]

[ "PF13707" ]

[ "RloB" ]

[ 3086 ]

1

[]

0

[]

0

[ "PUB00057366" ]

[ "9990732" ]

[ "Genetic organization and functional analysis of a novel phage abortive infection system, AbiL, from Lactococcus lactis." ]

[ 1999 ]

1

[]

0

null

[ "Bacteria", "Caudoviricetes", "Methanomicrobia", "unclassified sequences" ]

[ 2971, 6, 21, 88 ]

4

[]

0

true

Family

RloB-like protein

RloB

6

IPR025593

25,593

Growth arrest-specific protein 8 domain

GAS8_dom

Domain

2,634

false

This is the highly conserved central region of Gas8 proteins. Growth arrest-specific protein 8 (Gas8) is a microtubule-binding protein localised to regions of dynein regulation in mammalian cells. In mouse, Gas8 is predominantly a testicular protein, whose expression is developmentally regulated during puberty and sper...

[ "GO:0048870", "GO:0031514" ]

[ "cell motility", "motile cilium" ]

[ "biological_process", "cellular_component" ]

2

[ "PFAM" ]

[ "PF13851" ]

[ "GAS" ]

[ 2634 ]

1

[ "REACTOME", "REACTOME" ]

[ "R-HSA-5635838", "R-MMU-5635838" ]

[ "REACTOME:R-HSA-5635838", "REACTOME:R-MMU-5635838" ]

2

[ "7ju4", "8glv", "8j07", "8tek", "8th8", "8tid", "9e5c", "9fqr" ]

8

[ "PUB00057367" ]

[ "11751847" ]

[ "Isolation and properties of Gas8, a growth arrest-specific gene regulated during male gametogenesis to produce a protein associated with the sperm motility apparatus." ]

[ 2002 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "Halogranum amylolyticum", "marine metagenome" ]

[ 7, 2625, 1, 1 ]

4

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 3, 7, 4, 6 ]

5

true

Domain

Growth arrest-specific protein 8 domain

GAS8_dom

2

IPR025594

25,594

YebO-like protein

YebO

Family

1,079

false

This family of proteins includes YebO, which is functionally uncharacterised. Their distribution suggests that they may be of phage origin.

[]

0

[ "PFAM" ]

[ "PF13974" ]

[ "YebO" ]

[ 1079 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Beauveria bassiana D1-5", "Caudoviricetes", "human gut metagenome" ]

[ 1056, 1, 21, 1 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

YebO-like protein

YebO

8

IPR025595

25,595

Ycf91-like

Domain

1,395

false

This domain is found in Uncharacterized protein ycf91, MJ0107 and related proteins from bacteria, archaea and a few lower eukaryotic species. It contains two conserved sequence motifs: LDP and DHA. MJ0107 does not possess dihydropteroate synthase activity [ ]. In bacteria, this domain is found in predicted conflict sys...

[]

0

[ "PFAM" ]

[ "PF14251" ]

[ "PterinBD-DUF4346" ]

[ 1395 ]

1

[]

0

[]

0

[ "PUB00057368", "PUB00155486" ]

[ "10426953", "37889040" ]

[ "Identifying two ancient enzymes in Archaea using predicted secondary structure alignment.", "Functionally comparable but evolutionarily distinct nucleotide-targeting effectors help identify conserved paradigms across diverse immune systems." ]

[ 1999, 2023 ]

2

[]

0

null

[ "Archaea", "Bacteria", "Bacteriophage sp.", "Eukaryota", "metagenomes" ]

[ 432, 773, 1, 143, 46 ]

5

[]

0

true

Domain

Ycf91-like

7

IPR025596

25,596

Lipocalin LPS transport optimiser YedD

YedD

Family

1,015

false

This entry represents the bacterial lipocalin YedD, an outer membrane lipoprotein found in Enterobacterales. YedD forms a stable 1:1:1 ternary complex with the LptDE translocon, which is responsible for inserting lipopolysaccharide (LPS) into the outer leaflet of the outer membrane [ ]. Structural analysis reveals that...

[]

0

[ "NCBIFAM", "PFAM" ]

[ "NF007705", "PF13987" ]

[ "PRK10397.1", "YedD" ]

[ 901, 1015 ]

2

[]

0

[ "4hwm", "9fz5" ]

2

[ "PUB00162416" ]

[ "39492858" ]

[ "Tuberculous otomastoiditis in children complicated by homolateral sigmoid sinus thrombosis: a case report." ]

[ 2024 ]

1

[]

0

null

[ "Bacteria", "Opisthokonta", "Vieuvirus", "human gut metagenome" ]

[ 1010, 2, 2, 1 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Lipocalin LPS transport optimiser YedD

YedD

2

IPR025597

25,597

Protein of unknown function DUF4345

DUF4345

Family

3,225

false

This family of proteins is uncharacterised. Proteins in this family contain a single completely conserved residue E that may be functionally important.

[]

0

[ "PFAM" ]

[ "PF14248" ]

[ "DUF4345" ]

[ 3225 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Sym plasmid", "ecological metagenomes" ]

[ 2995, 197, 1, 32 ]

4

[]

0

true

Family

Protein of unknown function DUF4345

DUF4345

2

IPR025599

25,599

Regulator of diguanylate cyclase RdcB

Rdcb

Family

621

false

This entry represents regulator of diguanylate cyclase RdcB and related proteins. RdcB is a regulatory protein that, together with its partner protein RdcA, activates diguanylate cyclase E (DgcE) to control CsgD and biofilm matrix production [ ]. RdcB acts as an accessory component, forming a complex with RdcA and cont...

[]

0

[ "PFAM" ]

[ "PF13990" ]

[ "YjcZ" ]

[ 621 ]

1

[]

0

[]

0

[ "PUB00100647" ]

[ "31022167" ]

[ "Genetic dissection of Escherichia coli's master diguanylate cyclase DgcE: Role of the N-terminal MASE1 domain and direct signal input from a GTPase partner system." ]

[ 2019 ]

1

[]

0

null

[ "Bacteria", "Trichuris trichiura" ]

[ 620, 1 ]

2

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Regulator of diguanylate cyclase RdcB

Rdcb

8

IPR025600

25,600

YccJ-like protein

YccJ

Family

869

false

The YccJ-like family of proteins is named after the functionally uncharacterised E. coli YccJ protein ( ) [ ].

[]

0

[ "NCBIFAM", "PFAM" ]

[ "NF007554", "PF13993" ]

[ "PRK10174.1", "YccJ" ]

[ 847, 869 ]

2

[]

0

[]

0

[ "PUB00009964" ]

[ "9868784" ]

[ "Small genes/gene-products in Escherichia coli K-12." ]

[ 1998 ]

1

[]

0

null

[ "Bacteria", "Beauveria bassiana D1-5" ]

[ 868, 1 ]

2

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

YccJ-like protein

YccJ

4

IPR025601

25,601

ATP-binding sugar transporter-like protein

ATP-bd_sugar_transptr-like

Family

437

false

Members of this family are putative ATP-binding sugar transporter-like protein. This entry also includes the phage Head-tail joining protein, known as Gp10 from Bacteriophage N15. It plays a role in virion assembly by joining the head and the tail at the last step of morphogenesis.

[]

0

[ "PFAM" ]

[ "PF13856" ]

[ "Gifsy-2" ]

[ 437 ]

1

[]

0

[ "2pp6" ]

1

[]

0

[]

0

null

[ "Bacteria", "Viruses" ]

[ 430, 7 ]

2

[]

0

true

Family

ATP-binding sugar transporter-like protein

ATP-bd_sugar_transptr-like

1

IPR025602

25,602

BCP1 family

BCP1_family

Family

4,954

false

This family of proteins includes BRCA2 and CDKN1A-interacting protein (BCCIP) and Bcp1. In fungi, Bcp1 is involved in nuclear export, actin cytoskeleton organisation and vesicular transport [ ]. Its homologue in human and mouse, BCCIP, may promote cell cycle arrest by enhancing the inhibition of CDK2 activity by CDKN1A...

[]

0

[ "PFAM", "PIRSF", "PANTHER" ]

[ "PF13862", "PIRSF028983", "PTHR13261" ]

[ "BCCIP", "BCP1", "" ]

[ 4923, 3365, 4850 ]

3

[]

0

[ "7c4h", "7kyq", "7kys", "8eqb", "8exe", "8exf" ]

6

[ "PUB00057369", "PUB00057370", "PUB00062410", "PUB00062411", "PUB00062412" ]

[ "10878006", "12912920", "14726710", "15713648", "17947333" ]

[ "TOK-1, a novel p21Cip1-binding protein that cooperatively enhances p21-dependent inhibitory activity toward CDK2 kinase.", "Regulation of PI4,5P2 synthesis by nuclear-cytoplasmic shuttling of the Mss4 lipid kinase.", "Inhibition of G1 to S cell cycle progression by BCCIP beta.", "The BRCA2-interacting protei...

[ 2000, 2003, 2004, 2005, 2007 ]

5

[]

0

null

[ "Eukaryota" ]

[ 4954 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 16, 1, 2, 1, 3, 1, 1, 3, 6, 1, 1, 4 ]

12

true

Family

BCP1 family

BCP1_family

4

IPR025603

25,603

YebF/Colicin-M immunity protein

YebF/ColM_immunity

Family

984

false

This family includes the colicin M immunity protein Cmi, and the protein of unknown function YebF. Cmi protects cells from the colicin M toxin, though the mechanism by which it achieves this is not known [ ]. The protein forms an α-β fold and contains a disulphide bond that is essential for function [ ]. Although the f...

[]

0

[ "PFAM", "PROFILE" ]

[ "PF13995", "PS51979" ]

[ "YebF", "YEBF_CMI" ]

[ 968, 983 ]

2

[]

0

[ "2lqv", "2xgl", "4aeq" ]

3

[ "PUB00053960", "PUB00057375", "PUB00057376" ]

[ "16369539", "2820942", "21037007" ]

[ "Extracellular accumulation of recombinant proteins fused to the carrier protein YebF in Escherichia coli.", "Sequence, expression, and localization of the immunity protein for colicin M.", "X-ray structure and site-directed mutagenesis analysis of the Escherichia coli colicin M immunity protein." ]

[ 2006, 1987, 2011 ]

3

[]

[ "IPR020236" ]

0

1

0

[ "Bacteria", "Plasmid ColBM-Cl139", "Trichuris trichiura", "human gut metagenome" ]

[ 981, 1, 1, 1 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

YebF/Colicin-M immunity protein

YebF/ColM_immunity

2

IPR025604

25,604

Actin cytoskeleton-regulatory complex protein End3

End3

Family

1,269

false

Endocytosis is accomplished through the sequential recruitment at endocytic sites of proteins that drive cargo sorting, membrane invagination and vesicle release [ ]. End3 forms a complex with Pan1 and Sla1 [ ]. This complex plays important roles in organisation of the actin cytoskeleton and endocytosis [ , ]. This com...

[ "GO:0006897", "GO:0007015" ]

[ "endocytosis", "actin filament organization" ]

[ "biological_process", "biological_process" ]

2

[ "PFAM" ]

[ "PF12761" ]

[ "End3" ]

[ 1269 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-SCE-416482", "R-SCE-8856828", "R-SCE-9013148", "R-SCE-9013406", "R-SCE-9013420", "R-SPO-416482", "R-SPO-8856828", "R-SPO-9013148", "R-SPO-9013406", "R-SPO-9013420" ]

[ "REACTOME:R-SCE-416482", "REACTOME:R-SCE-8856828", "REACTOME:R-SCE-9013148", "REACTOME:R-SCE-9013406", "REACTOME:R-SCE-9013420", "REACTOME:R-SPO-416482", "REACTOME:R-SPO-8856828", "REACTOME:R-SPO-9013148", "REACTOME:R-SPO-9013406", "REACTOME:R-SPO-9013420" ]

10

[]

0

[ "PUB00020335", "PUB00057371" ]

[ "10594004", "9234686" ]

[ "Pan1p, End3p, and S1a1p, three yeast proteins required for normal cortical actin cytoskeleton organization, associate with each other and play essential roles in cell wall morphogenesis.", "EH domain proteins Pan1p and End3p are components of a complex that plays a dual role in organization of the cortical actin...

[ 2000, 1997 ]

2

[]

0

null

[ "Bacteria", "Eukaryota" ]

[ 6, 1263 ]

2

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 1, 1 ]

3

true

Family

Actin cytoskeleton-regulatory complex protein End3

End3

4

IPR025606

25,606

NLPC/P60, N-terminal domain

NLPC/P60_N_dom

Domain

580

false

This domain is found at the N terminus of , which is a four-domain protein that possesses a C-terminal NLP/P60 domain ( ). The N-terminal domain appears to act as a stabilising domain.

[]

0

[ "PFAM" ]

[ "PF12912" ]

[ "N_NLPC_P60" ]

[ 580 ]

1

[]

0

[ "3m1u" ]

1

[]

0

[]

0

null

[ "Bacteria", "ecological metagenomes" ]

[ 565, 15 ]

2

[]

0

true

Domain

NLPC/P60, N-terminal domain

NLPC/P60_N_dom

5

IPR025607

25,607

Large ribosomal subunit protein uL18, C-terminal, eukaryotes

Ribosomal_uL18_C_euk

Domain

6,265

false

This entry represents the C-terminal domain of the large ribosomal subunit protein uL18 (also known as L5) from eukaryotes.

[]

0

[ "PFAM" ]

[ "PF14204" ]

[ "Ribosomal_L18_c" ]

[ 6265 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-156827", "R-BTA-1799339", "R-BTA-6791226", "R-BTA-72689", "R-BTA-72706", "R-BTA-975956", "R-BTA-975957", "R-CEL-156827", "R-CEL-1799339", "R-CEL-72689", "R-CEL-72706", "R-CEL-975956", "R-CEL-975957", "R-DDI-156827", "R-DDI-1799339", "R-DDI-72689", "R-DDI-72706", "R-DDI-97595...

[ "REACTOME:R-BTA-156827", "REACTOME:R-BTA-1799339", "REACTOME:R-BTA-6791226", "REACTOME:R-BTA-72689", "REACTOME:R-BTA-72706", "REACTOME:R-BTA-975956", "REACTOME:R-BTA-975957", "REACTOME:R-CEL-156827", "REACTOME:R-CEL-1799339", "REACTOME:R-CEL-72689", "REACTOME:R-CEL-72706", "REACTOME:R-CEL-9759...

69

[ "3j6x", "3j6y", "3j77", "3j78", "3j79", "3j7o", "3j7p", "3j7q", "3j7r", "3j92", "3jag", "3jah", "3jai", "3jaj", "3jan", "3jbn", "3jbo", "3jbp", "3jcs", "3jct", "4d5y", "4d67", "4u3m", "4u3n", "4u3u", "4u4n", "4u4o", "4u4q", "4u4r", "4u4u", "4u4y", "4u4z"...

530

[]

0

[]

0

null

[ "Eukaryota", "Halopseudomonas pelagia" ]

[ 6264, 1 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 13, 1, 2, 4, 6, 5, 1, 5, 3, 1, 2, 16 ]

12

true

Domain

Large ribosomal subunit protein uL18, C-terminal, eukaryotes

Ribosomal_uL18_C_euk

5

IPR025608

25,608

TcpE family

TcpE

Family

1,727

false

This family of proteins includes TcpE, a bacterial conjugative transposon membrane protein.

[]

0

[ "PFAM" ]

[ "PF12648" ]

[ "TcpE" ]

[ 1727 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Caudoviricetes", "metagenomes" ]

[ 1718, 3, 6 ]

3

[]

0

true

Family

TcpE family

TcpE

8

IPR025609

25,609

Lsm14-like, N-terminal

Lsm14-like_N

Domain

9,794

false

The Lsm14 N-terminal domain is a type of LSM domain found in Lsm14 proteins (also known as Rap55) [ , ] and in the Saccharomyces cerevisiae homologue Scd6 [ ]. The domain is also found in the human EDC3 protein (enhancer of mRNA-decapping protein 3) where it is fused to the the Rossmanoid YjeF-N domain [ ]. In addition...

[]

0

[ "PFAM", "SMART", "CDD" ]

[ "PF12701", "SM01271", "cd01736" ]

[ "LSM14", "LSM14", "LSm14_N" ]

[ 9435, 9731, 6949 ]

3

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-DME-430039", "R-DRE-430039", "R-HSA-430039", "R-MMU-430039" ]

[ "REACTOME:R-DME-430039", "REACTOME:R-DRE-430039", "REACTOME:R-HSA-430039", "REACTOME:R-MMU-430039" ]

4

[ "2fb7", "2rm4", "2vc8", "2vxe", "2vxf", "6f9w" ]

6

[ "PUB00043768", "PUB00044226", "PUB00057871", "PUB00057872" ]

[ "15257761", "15225602", "17074753", "18723115" ]

[ "Novel conserved domains in proteins with predicted roles in eukaryotic cell-cycle regulation, decapping and RNA stability.", "Novel Sm-like proteins with long C-terminal tails and associated methyltransferases.", "RAP55, a cytoplasmic mRNP component, represses translation in Xenopus oocytes.", "RAP55: insigh...

[ 2004, 2004, 2006, 2009 ]

4

[]

[ "IPR034107" ]

0

1

0

[ "Eukaryota" ]

[ 9794 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 17, 2, 16, 10, 17, 8, 1, 5, 12, 1, 1, 36 ]

12

true

Domain

Lsm14-like, N-terminal

Lsm14-like_N

1

IPR025610

25,610

Transcription factor MYC/MYB N-terminal

MYC/MYB_N

Domain

13,337

false

This is the N-terminal region of a family of MYB and MYC transcription factors. The DNA-binding HLH domain is further downstream, . Members of the MYB and MYC family regulate the biosynthesis of phenylpropanoids in several plant species [ , ].

[]

0

[ "PFAM" ]

[ "PF14215" ]

[ "bHLH-MYC_N" ]

[ 13337 ]

1

[]

0

[ "4rqw", "4rru", "4rs9", "4ywc", "4yz6", "5t0f", "5t0q", "7fdl", "7fdm", "7fdn", "7fdo", "8t2i" ]

12

[ "PUB00057377", "PUB00057378" ]

[ "10066590", "20112051" ]

[ "Phenylpropanoid biosynthesis and its regulation.", "Isolation of WDR and bHLH genes related to flavonoid synthesis in grapevine (Vitis vinifera L.)." ]

[ 1998, 2010 ]

2

[]

0

null

[ "Cyanophyceae", "Eukaryota" ]

[ 2, 13335 ]

2

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 139, 55, 113 ]

3

true

Domain

Transcription factor MYC/MYB N-terminal

MYC/MYB_N

3

IPR025611

25,611

YobH-like protein

YobH

Family

933

false

The YobH-like protein family includes the YobH protein from E. coli , which is functionally uncharacterised. Proteins in this family are approximately 80 amino acids in length and contain two conserved sequence motifs: GYG and GLGL.

[]

0

[ "PFAM" ]

[ "PF13996" ]

[ "YobH" ]

[ 933 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Gammaproteobacteria", "Lasius niger" ]

[ 932, 1 ]

2

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

YobH-like protein

YobH

3

IPR025612

25,612

YqjK-like protein

YqjK

Family

1,577

false

The YqjK-like protein family includes the E. coli YqjK protein , which is functionally uncharacterised. There is a single completely conserved residue R that may be functionally important.

[]

0

[ "PFAM" ]

[ "PF13997" ]

[ "YqjK" ]

[ 1577 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "metagenomes" ]

[ 1567, 10 ]

2

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

YqjK-like protein

YqjK

5

IPR025613

25,613

YlbE-like protein

YlbE

Family

737

false

The YlbE-like protein family includes the B. subtilis protein YlbE , which is functionally uncharacterised. Proteins in this family are approximately 80 amino acids in length and contain a conserved WYR sequence motif.

[]

0

[ "PFAM" ]

[ "PF14003" ]

[ "YlbE" ]

[ 737 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "human gut metagenome" ]

[ 736, 1 ]

2

[]

0

true

Family

YlbE-like protein

YlbE

1

IPR025614

25,614

Cell morphogenesis protein N-terminal

Cell_morpho_N

Domain

8,241

false

This entry represents the conserved N-terminal domain of proteins that are involved in cell morphogenesis. Among these are furry proteins and homologues [ , ], and proteins PAG1 [ ] and Mor2 [ ].

[]

0

[ "PFAM" ]

[ "PF14222" ]

[ "MOR2-PAG1_N" ]

[ 8241 ]

1

[]

0

[]

0

[ "PUB00057347", "PUB00057379", "PUB00057380", "PUB00057381" ]

[ "12234926", "11526084", "16061630", "11854408" ]

[ "Fission yeast Mor2/Cps12, a protein similar to Drosophila Furry, is essential for cell morphogenesis and its mutation induces Wee1-dependent G(2) delay.", "The furry gene of Drosophila is important for maintaining the integrity of cellular extensions during morphogenesis.", "AF4p12, a human homologue to the fu...

[ 2002, 2001, 2005, 2002 ]

4

[]

0

null

[ "Eukaryota" ]

[ 8241 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 3, 2, 60, 8, 12, 8, 1, 2, 15, 1, 1, 11 ]

12

true

Domain

Cell morphogenesis protein N-terminal

Cell_morpho_N

8

IPR025615

25,615

TILa domain

TILa_dom

Domain

5,165

false

This cysteine rich domain often occurs along side the TIL domain ( ) and may be a distantly related relative.

[]

0

[ "PFAM" ]

[ "PF12714" ]

[ "TILa" ]

[ 5165 ]

1

[ "REACTOME", "REACTOME" ]

[ "R-HSA-163125", "R-MMU-163125" ]

[ "REACTOME:R-HSA-163125", "REACTOME:R-MMU-163125" ]

2

[ "8r0t", "8rde" ]

2

[]

0

[]

0

null

[ "Eumetazoa" ]

[ 5165 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 15, 7, 17, 10 ]

4

true

Domain

TILa domain

TILa_dom

9

IPR025616

25,616

YpjP-like protein

YpjP

Family

916

false

The YpjP-like protein family includes the B. subtilis YpjP protein , which is functionally uncharacterised.

[]

0

[ "PFAM" ]

[ "PF14005" ]

[ "YpjP" ]

[ 916 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacillota", "Rhizophagus irregularis" ]

[ 915, 1 ]

2

[]

0

true

Family

YpjP-like protein

YpjP

3

IPR025617

25,617

YqzL-like protein

YqzL

Family

1,194

false

The YqzL-like protein family includes the B. subtilis YqzL protein , which is functionally uncharacterised.

[]

0

[ "PFAM" ]

[ "PF14006" ]

[ "YqzL" ]

[ 1194 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacillati", "bioreactor metagenome" ]

[ 1192, 2 ]

2

[]

0

true

Family

YqzL-like protein

YqzL

4

IPR025618

25,618

YtpI-like protein

YtpI

Family

1,395

false

The YtpI-like protein family includes the B. subtilis YtpI protein , which is functionally uncharacterised.

[]

0

[ "PFAM" ]

[ "PF14007" ]

[ "YtpI" ]

[ 1395 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria" ]

[ 1395 ]

1

[]

0

true

Family

YtpI-like protein

YtpI

3

IPR025619

25,619

YlzJ-like protein

YlzJ

Family

1,473

false

The YlzJ-like protein family includes the B. subtilis YlzJ protein , which is functionally uncharacterised. Proteins in this family are typically between 61 and 72 amino acids in length and contain two completely conserved residues (L and G) that may be functionally important.

[]

0

[ "PFAM" ]

[ "PF14035" ]

[ "YlzJ" ]

[ 1473 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacillota", "ecological metagenomes" ]

[ 1468, 5 ]

2

[]

0

true

Family

YlzJ-like protein

YlzJ

7