Datasets:
LiteFold
/
InterPro

Dataset card Data Studio Files
xet
 Community
interpro_id
string
interpro_numeric_id
int64
name
string
short_name
string
entry_type
string
protein_count
int64
is_llm
bool
is_llm_reviewed
bool
abstract
string
go_ids
list
go_terms
list
go_categories
list
go_count
int64
member_databases
list
member_accessions
list
member_names
list
member_protein_counts
list
member_count
int64
external_databases
list
external_accessions
list
external_xrefs
list
external_xref_count
int64
pdb_ids
list
structure_count
int64
publication_ids
list
pubmed_ids
list
publication_titles
list
publication_years
list
publication_count
int64
parent_ids
list
child_ids
list
parent_count
int64
child_count
int64
tree_depth
float64
taxonomy_names
list
taxonomy_protein_counts
list
taxonomy_count
int64
key_species_names
list
key_species_protein_counts
list
key_species_count
int64
in_entry_list
bool
entry_list_type
string
entry_list_name
string
names_dat_name
string
short_names_dat_name
string
split_bucket
int64
IPR025388
25,388
Alginate export domain
Alginate_export_dom
Domain
7,159
false
false
This domain forms an 18-stranded β-barrel pore which is likely to act as an alginate export channel [ ].
[]
[]
[]
0
[ "PFAM" ]
[ "PF13372" ]
[ "Alginate_exp" ]
[ 7159 ]
1
[]
[]
[]
0
[ "3rbh", "4afk", "4azl", "4b61", "4xnk", "4xnl", "5d5d", "5iyu", "7acg", "8pz4", "8q2o", "8rqp" ]
12
[ "PUB00056376" ]
[ "21778407" ]
[ "Structural basis for alginate secretion across the bacterial outer membrane." ]
[ 2011 ]
1
[]
[]
0
0
null
[ "Bacteria", "Eukaryota", "unclassified sequences" ]
[ 7071, 11, 77 ]
3
[ "Oryza sativa subsp. japonica" ]
[ 1 ]
1
true
Domain
Alginate export domain
Alginate export domain
Alginate_export_dom
8
IPR025389
25,389
Domain of unknown function DUF4300
DUF4300
Domain
585
false
false
This entry represents a domain of unkown function found in lipoproteins. It is found in bacteria. They are typically between 281 and 303 amino acids in length and contain two conserved sequence motifs: NCR and PYQ.
[]
[]
[]
0
[ "PFAM" ]
[ "PF14133" ]
[ "DUF4300" ]
[ 585 ]
1
[]
[]
[]
0
[ "9ow2" ]
1
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Bacteria", "Siphoviridae sp. ctFIm6", "bioreactor metagenome" ]
[ 583, 1, 1 ]
3
[]
[]
0
true
Domain
Domain of unknown function DUF4300
Domain of unknown function DUF4300
DUF4300
9
IPR025390
25,390
DSC E3 ubiquitin ligase complex subunit 3, C-terminal
Dsc3_C
Domain
1,799
false
false
This is the C-terminal domain of DSC E3 ubiquitin ligase complex subunit 3 (Dsc3), which contains two transmembrane helices and a characteristic GFDRL sequence motif. Dsc3 is a component of the DSC E3 ubiquitin ligase complex (a Golgi-specific protein ubiquitination system) that functions in protein homeostasis under n...
[]
[]
[]
0
[ "PFAM" ]
[ "PF13373" ]
[ "Dsc3_C" ]
[ 1799 ]
1
[]
[]
[]
0
[]
0
[ "PUB00066734", "PUB00075404", "PUB00098082", "PUB00098312", "PUB00098314" ]
[ "21777356", "21504829", "29355480", "25078903", "31368600" ]
[ "An overexpression screen in Saccharomyces cerevisiae identifies novel genes that affect endocytic protein trafficking.", "Yeast SREBP cleavage activation requires the Golgi Dsc E3 ligase complex.", "Sorting of a multi-subunit ubiquitin ligase complex in the endolysosome system.", "Identification of candidate...
[ 2011, 2011, 2018, 2014, 2019 ]
5
[]
[]
0
0
null
[ "Eukaryota" ]
[ 1799 ]
1
[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]
[ 1, 1, 1 ]
3
true
Domain
DSC E3 ubiquitin ligase complex subunit 3, C-terminal
DSC E3 ubiquitin ligase complex subunit 3, C-terminal
Dsc3_C
3
IPR025391
25,391
Domain of unknown function DUF4123
DUF4123
Domain
6,233
false
false
This presumed domain is functionally uncharacterised.
[]
[]
[]
0
[ "PFAM" ]
[ "PF13503" ]
[ "DUF4123" ]
[ 6233 ]
1
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Aresaunavirus", "Bacteria", "Eukaryota", "unclassified sequences" ]
[ 2, 6176, 6, 49 ]
4
[]
[]
0
true
Domain
Domain of unknown function DUF4123
Domain of unknown function DUF4123
DUF4123
8
IPR025392
25,392
Domain of unknown function DUF4124
DUF4124
Domain
11,903
false
false
This presumed domain is functionally uncharacterised, but it may have an Ig-like fold.
[]
[]
[]
0
[ "PFAM" ]
[ "PF13511" ]
[ "DUF4124" ]
[ 11903 ]
1
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Bacteria", "Eukaryota", "Viruses", "environmental samples", "unclassified sequences" ]
[ 11671, 8, 5, 4, 215 ]
5
[]
[]
0
true
Domain
Domain of unknown function DUF4124
Domain of unknown function DUF4124
DUF4124
2
IPR025393
25,393
Domain of unknown function DUF4301
DUF4301
Domain
1,815
false
false
This domain is functionally uncharacterised. It is found in bacteria.
[]
[]
[]
0
[ "PFAM" ]
[ "PF14134" ]
[ "DUF4301" ]
[ 1815 ]
1
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Bacteria", "metagenomes" ]
[ 1752, 63 ]
2
[]
[]
0
true
Domain
Domain of unknown function DUF4301
Domain of unknown function DUF4301
DUF4301
3
IPR025394
25,394
Protein of unknown function DUF4127
DUF4127
Family
1,344
false
false
This protein family is functionally uncharacterised.
[]
[]
[]
0
[ "PFAM" ]
[ "PF13552" ]
[ "DUF4127" ]
[ 1344 ]
1
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Bacteria", "Caudoviricetes", "Eukaryota", "metagenomes" ]
[ 1278, 5, 39, 22 ]
4
[]
[]
0
true
Family
Protein of unknown function DUF4127
Protein of unknown function DUF4127
DUF4127
2
IPR025395
25,395
PPhage tail terminator protein-like
Phage_tail_terminator-like
Family
1,449
false
false
This family of proteins is functionally uncharacterised. The structure of family member reveals a tail terminator protein gpU fold, which suggests that the protein could have a bacteriophage origin.
[]
[]
[]
0
[ "PFAM" ]
[ "PF13554" ]
[ "Phage_tail_terminator_5" ]
[ 1449 ]
1
[]
[]
[]
0
[ "2l25", "9jlf", "9kmh", "9l0e" ]
4
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Bacteria", "Eukaryota", "Viruses", "metagenomes" ]
[ 904, 4, 536, 5 ]
4
[]
[]
0
true
Family
PPhage tail terminator protein-like
PPhage tail terminator protein-like
Phage_tail_terminator-like
5
IPR025396
25,396
Protein of unknown function DUF4302
DUF4302
Family
1,254
false
false
This family of proteins is functionally uncharacterised. They contain two completely conserved residues (R and L) that may be functionally important.
[]
[]
[]
0
[ "PFAM" ]
[ "PF14135" ]
[ "DUF4302" ]
[ 1254 ]
1
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Bacteroidota", "Durusdinium trenchii", "Siphoviridae sp. ctJ0s2", "metagenomes" ]
[ 1235, 1, 1, 17 ]
4
[]
[]
0
true
Family
Protein of unknown function DUF4302
Protein of unknown function DUF4302
DUF4302
5
IPR025397
25,397
Succinate dehydrogenase subunit 5, mitochondrial
SDH5
Family
790
false
false
Complex II [succinate dehydrogenase (succinate-ubiquinone oxidoreductase); SDH] is the only enzyme shared by both the electron transport chain and the tricarboxylic acid (TCA) cycle in mitochondria. In plants, this complex is considered unusual because it has accessory subunits (SDH5-SDH8), in addition to the catalytic...
[ "GO:0006099", "GO:0045273" ]
[ "tricarboxylic acid cycle", "respiratory chain complex II (succinate dehydrogenase)" ]
[ "biological_process", "cellular_component" ]
2
[ "PFAM", "PANTHER" ]
[ "PF14290", "PTHR36139" ]
[ "SDH5_plant", "" ]
[ 790, 774 ]
2
[]
[]
[]
0
[]
0
[ "PUB00097630", "PUB00098021" ]
[ "30604579", "15604729" ]
[ "Mitochondrial complex II of plants: subunit composition, assembly, and function in respiration and signaling.", "Mitochondrial cytochrome c oxidase and succinate dehydrogenase complexes contain plant specific subunits." ]
[ 2019, 2004 ]
2
[]
[]
0
0
null
[ "Eukaryota" ]
[ 790 ]
1
[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]
[ 11, 1, 10 ]
3
true
Family
Succinate dehydrogenase subunit 5, mitochondrial
Succinate dehydrogenase subunit 5, mitochondrial
SDH5
1
IPR025398
25,398
ZMYM1-like, RNase-like domain
RNase-like_ZMYM1
Domain
22,126
false
false
This entry (ex DUF4371) represents a RNase-like domain in Zinc finger MYM-type protein 1 (ZMYM1), 52 kDa repressor of the inhibitor of the protein kinase (THAP12) and similar proteins mainly found in animals. THAP12 is an upstream regulator of interferon-induced serine/threonine protein kinase R (PKR). It may block the...
[]
[]
[]
0
[ "PFAM" ]
[ "PF14291" ]
[ "DUF4371" ]
[ 22126 ]
1
[]
[]
[]
0
[]
0
[ "PUB00162449" ]
[ "39047044" ]
[ "Disruption of the ZFP574-THAP12 complex suppresses B cell malignancies in mice." ]
[ 2024 ]
1
[]
[]
0
0
null
[ "Eukaryota" ]
[ 22126 ]
1
[ "Arabidopsis thaliana", "Danio rerio", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]
[ 58, 14, 7, 9, 56, 4, 116 ]
7
true
Domain
ZMYM1-like, RNase-like domain
ZMYM1-like, RNase-like domain
RNase-like_ZMYM1
9
IPR025399
25,399
Domain of unknown function DUF4372
DUF4372
Domain
2,587
false
false
This domain of unknown function often occurs at the N terminus of putative transposases.
[]
[]
[]
0
[ "PFAM" ]
[ "PF14294" ]
[ "DUF4372" ]
[ 2587 ]
1
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Bacteria", "Eukaryota", "unclassified sequences" ]
[ 2462, 5, 120 ]
3
[]
[]
0
true
Domain
Domain of unknown function DUF4372
Domain of unknown function DUF4372
DUF4372
1
IPR025400
25,400
Lin1244/Lin1753-like, N-terminal
Lin1244/Lin1753-like_N
Domain
1,609
false
false
The function of this domain is not known. It is found at the N-terminal of the uncharacterised phage-related protein Lin1244/Lin1753 which contains a DnaD domain ( ) at the C-terminal.
[]
[]
[]
0
[ "PFAM" ]
[ "PF14297" ]
[ "Lin1244_N" ]
[ 1609 ]
1
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Bacteria", "Candidatus Methanofastidiosum methylothiophilum", "Eukaryota", "Viruses", "unclassified sequences" ]
[ 1475, 2, 3, 73, 56 ]
5
[]
[]
0
true
Domain
Lin1244/Lin1753-like, N-terminal
Lin1244/Lin1753-like, N-terminal
Lin1244/Lin1753-like_N
2
IPR025401
25,401
XusB
XusB
Family
2,256
false
false
This entry represents XusB , a surface-exposed lipoprotein found exclusively in Bacteroidetes that functions in xenosiderophore acquisition. XusB adopts a unique seven-bladed β-propeller fold with a deep, positively charged central calyx that binds enterobactin and other catecholate siderophores with high affinity (Kd ...
[]
[]
[]
0
[ "PFAM" ]
[ "PF14298" ]
[ "XusB" ]
[ 2256 ]
1
[]
[]
[]
0
[ "8gex", "9gar", "9gbc", "9gcy", "9gcz", "9hq1", "9hqe", "9hqk" ]
8
[ "PUB00162406", "PUB00162407" ]
[ "37749108", "32014901" ]
[ "Deep learning-enabled realistic virtual histology with ultraviolet photoacoustic remote sensing microscopy.", "C-myc Contributes to Malignancy of Lung Cancer: A Potential Anticancer Drug Target." ]
[ 2023, 2020 ]
2
[]
[]
0
0
null
[ "Pocillopora damicornis", "Pseudomonadati", "metagenomes" ]
[ 1, 2250, 5 ]
3
[]
[]
0
true
Family
XusB
XusB
XusB
8
IPR025402
25,402
DNA mimic protein DMP19, C-terminal
DMP19_C
Domain
2,445
false
false
This entry represents the C-terminal domain in DMP19 from Neisseria meningitidis (NMB0541) and similar proteins. This domain is also found in other bacterial uncharacterised proteins. DMP19 is a DNA mimic protein able to prevent the transcription factor NHTF from binding to a recognition box, playing a role in gene reg...
[]
[]
[]
0
[ "PFAM" ]
[ "PF14300" ]
[ "DMP19" ]
[ 2445 ]
1
[]
[]
[]
0
[ "3vjz", "3wur" ]
2
[ "PUB00100992" ]
[ "22373915" ]
[ "Neisseria conserved protein DMP19 is a DNA mimic protein that prevents DNA binding to a hypothetical nitrogen-response transcription factor." ]
[ 2012 ]
1
[]
[]
0
0
null
[ "Bacteria", "Fungi", "metagenomes" ]
[ 2421, 2, 22 ]
3
[]
[]
0
true
Domain
DNA mimic protein DMP19, C-terminal
DNA mimic protein DMP19, C-terminal
DMP19_C
2
IPR025404
25,404
Domain of unknown function DUF4130
DUF4130
Domain
6,282
false
false
This presumed domain is functionally uncharacterised.
[]
[]
[]
0
[ "PFAM" ]
[ "PF13566" ]
[ "DUF4130" ]
[ 6282 ]
1
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Archaea", "Bacteria", "Opisthokonta", "Siphoviridae sp. ctYaH2", "unclassified sequences" ]
[ 39, 6167, 5, 1, 70 ]
5
[]
[]
0
true
Domain
Domain of unknown function DUF4130
Domain of unknown function DUF4130
DUF4130
5
IPR025405
25,405
Domain of unknown function DUF4131
DUF4131
Domain
16,370
false
false
This functionally uncharacterised domain is frequently found in the N-terminal section of bacterial proteins involved in competence.
[]
[]
[]
0
[ "PFAM" ]
[ "PF13567" ]
[ "DUF4131" ]
[ 16370 ]
1
[]
[]
[]
0
[ "9iew" ]
1
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Bacteria", "Eukaryota", "Siphoviridae sp. ctBLh2", "unclassified sequences" ]
[ 16162, 11, 1, 196 ]
4
[]
[]
0
true
Domain
Domain of unknown function DUF4131
Domain of unknown function DUF4131
DUF4131
9
IPR025406
25,406
Domain of unknown function DUF4132
DUF4132
Domain
5,474
false
false
This presumed domain is functionally uncharacterised.
[]
[]
[]
0
[ "PFAM" ]
[ "PF13569" ]
[ "DUF4132" ]
[ 5474 ]
1
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Bacteria", "Methanobrevibacter filiformis", "Phytophthora kernoviae 00238/432", "metagenomes" ]
[ 5470, 1, 1, 2 ]
4
[ "Escherichia coli (strain K12)" ]
[ 1 ]
1
true
Domain
Domain of unknown function DUF4132
Domain of unknown function DUF4132
DUF4132
5
IPR025407
25,407
Protein of unknown function DUF4133
DUF4133
Family
2,458
false
false
This entry represents proteins of unknown function found primarily in Bacteroides species. The B. thetaiotaomicron gene appears to be upregulated in the presence of host or other bacterial species compared to growth in pure culture [ , ].
[]
[]
[]
0
[ "PFAM" ]
[ "PF13571" ]
[ "DUF4133" ]
[ 2458 ]
1
[]
[]
[]
0
[]
0
[ "PUB00056011", "PUB00056012" ]
[ "15790854", "16735464" ]
[ "Glycan foraging in vivo by an intestine-adapted bacterial symbiont.", "A hybrid two-component system protein of a prominent human gut symbiont couples glycan sensing in vivo to carbohydrate metabolism." ]
[ 2005, 2006 ]
2
[]
[]
0
0
null
[ "Pseudomonadati", "Viruses", "metagenomes" ]
[ 2424, 2, 32 ]
3
[]
[]
0
true
Family
Protein of unknown function DUF4133
Protein of unknown function DUF4133
DUF4133
2
IPR025408
25,408
Protein of unknown function DUF4134
DUF4134
Family
3,564
false
false
This entry represents proteins of unknown function found primarily in Bacteroides species. The B. thetaiotaomicron gene appears to be upregulated in the presence of host or other bacterial species compared to growth in pure culture [ , ].
[]
[]
[]
0
[ "PFAM" ]
[ "PF13572" ]
[ "DUF4134" ]
[ 3564 ]
1
[]
[]
[]
0
[]
0
[ "PUB00056011", "PUB00056012" ]
[ "15790854", "16735464" ]
[ "Glycan foraging in vivo by an intestine-adapted bacterial symbiont.", "A hybrid two-component system protein of a prominent human gut symbiont couples glycan sensing in vivo to carbohydrate metabolism." ]
[ 2005, 2006 ]
2
[]
[]
0
0
null
[ "Bacteria", "Tanacetum cinerariifolium", "Viruses", "metagenomes" ]
[ 3522, 1, 3, 38 ]
4
[]
[]
0
true
Family
Protein of unknown function DUF4134
Protein of unknown function DUF4134
DUF4134
8
IPR025409
25,409
Protein of unknown function DUF4303
DUF4303
Family
1,038
false
false
This family of proteins is functionally uncharacterised.
[]
[]
[]
0
[ "PFAM" ]
[ "PF14136" ]
[ "DUF4303" ]
[ 1038 ]
1
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Bacteria", "Opisthokonta", "ecological metagenomes" ]
[ 1030, 3, 5 ]
3
[]
[]
0
true
Family
Protein of unknown function DUF4303
Protein of unknown function DUF4303
DUF4303
4
IPR025410
25,410
Lantibiotic biosynthesis protein, dehydration domain
Lant_dehyd
Domain
2,716
false
false
This domain is found in proteins involved in the synthesis of lantibiotic compounds. It is found at the N terminus of NukM, the post-translational modification enzyme of lantibiotic nukacin ISK-1, where it has been shown to be mainly responsible for substrate recognition and dehydration [ ].
[]
[]
[]
0
[ "PFAM" ]
[ "PF13575" ]
[ "DUF4135" ]
[ 2716 ]
1
[]
[]
[]
0
[ "5dzt", "6st5" ]
2
[ "PUB00081043" ]
[ "25971839" ]
[ "In vitro catalytic activity of N-terminal and C-terminal domains in NukM, the post-translational modification enzyme of nukacin ISK-1." ]
[ 2015 ]
1
[]
[]
0
0
null
[ "Bacteria", "Eukaryota", "Halobacteriales", "Plasmid pAD1", "ecological metagenomes" ]
[ 2666, 21, 23, 1, 5 ]
5
[]
[]
0
true
Domain
Lantibiotic biosynthesis protein, dehydration domain
Lantibiotic biosynthesis protein, dehydration domain
Lant_dehyd
6
IPR025411
25,411
Domain of unknown function DUF4136
DUF4136
Domain
9,603
false
false
This domain is found in bacterial lipoproteins and PDZ domain-containing proteins. Its function is not known.
[]
[]
[]
0
[ "PFAM" ]
[ "PF13590" ]
[ "DUF4136" ]
[ 9603 ]
1
[]
[]
[]
0
[ "4f54", "4l8n" ]
2
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Bacteria", "Eukaryota", "Halorubrum tibetense", "unclassified sequences" ]
[ 9514, 3, 1, 85 ]
4
[]
[]
0
true
Domain
Domain of unknown function DUF4136
Domain of unknown function DUF4136
DUF4136
9
IPR025412
25,412
Protein of unknown function DUF4304
DUF4304
Family
1,383
false
false
This family of proteins is functionally uncharacterised.
[]
[]
[]
0
[ "PFAM" ]
[ "PF14137" ]
[ "DUF4304" ]
[ 1383 ]
1
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Archaea", "Bacteria", "Nephila pilipes", "metagenomes" ]
[ 2, 1375, 1, 5 ]
4
[]
[]
0
true
Family
Protein of unknown function DUF4304
Protein of unknown function DUF4304
DUF4304
5
IPR025413
25,413
YpzG-like protein
YpzG-like
Family
567
false
false
The YpzG-like protein family includes the Bacillus subtilis YpzG protein , which is functionally uncharacterised. This family of proteins is found in bacteria. Proteins in this family are approximately 50 amino acids in length and contain a conserved QVNG sequence motif.
[]
[]
[]
0
[ "PFAM" ]
[ "PF14139" ]
[ "YpzG" ]
[ 567 ]
1
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Bacilli" ]
[ 567 ]
1
[]
[]
0
true
Family
YpzG-like protein
YpzG-like protein
YpzG-like
7
IPR025414
25,414
YpzI-like protein
YpzI-like
Family
549
false
false
The YpzI-like protein family includes the Bacillus subtilis YpzI protein , which is functionally uncharacterised. Proteins in this family are approximately 40 amino acids in length.
[]
[]
[]
0
[ "PFAM" ]
[ "PF14140" ]
[ "YpzI" ]
[ 549 ]
1
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Bacillales" ]
[ 549 ]
1
[]
[]
0
true
Family
YpzI-like protein
YpzI-like protein
YpzI-like
5
IPR025415
25,415
Protein of unknown function DUF4141
DUF4141
Family
1,995
false
false
This entry represents proteins of unknown function found primarily in Bacteroides species. The B. thetaiotaomicron gene appears to be upregulated in the presence of host or other bacterial species compared to growth in pure culture [ , ].
[]
[]
[]
0
[ "PFAM" ]
[ "PF13605" ]
[ "DUF4141" ]
[ 1995 ]
1
[]
[]
[]
0
[]
0
[ "PUB00056011", "PUB00056012" ]
[ "15790854", "16735464" ]
[ "Glycan foraging in vivo by an intestine-adapted bacterial symbiont.", "A hybrid two-component system protein of a prominent human gut symbiont couples glycan sensing in vivo to carbohydrate metabolism." ]
[ 2005, 2006 ]
2
[]
[]
0
0
null
[ "Bacteria", "Gibberella intermedia", "unclassified sequences" ]
[ 1957, 1, 37 ]
3
[]
[]
0
true
Family
Protein of unknown function DUF4141
Protein of unknown function DUF4141
DUF4141
3
IPR025416
25,416
YqzM-like protein
YqzM
Family
973
false
false
The YqzM-like protein family includes the Bacillus subtilis YqzM protein , which is functionally uncharacterised. Proteins in this family are approximately 40 amino acids in length.
[]
[]
[]
0
[ "PFAM" ]
[ "PF14141" ]
[ "YqzM" ]
[ 973 ]
1
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Bacilli", "Rhizophagus irregularis" ]
[ 972, 1 ]
2
[]
[]
0
true
Family
YqzM-like protein
YqzM-like protein
YqzM
9
IPR025417
25,417
YrzO-like protein
YrzO-like
Family
148
false
false
The YrzO-like protein family includes the Bacillus subtilis YrzO protein , which is functionally uncharacterised.
[]
[]
[]
0
[ "PFAM" ]
[ "PF14142" ]
[ "YrzO" ]
[ 148 ]
1
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Bacillales" ]
[ 148 ]
1
[]
[]
0
true
Family
YrzO-like protein
YrzO-like protein
YrzO-like
6
IPR025419
25,419
Domain of unknown function DUF4142
DUF4142
Domain
11,110
false
false
This presumed domain is functionally uncharacterised.
[]
[]
[]
0
[ "PFAM" ]
[ "PF13628" ]
[ "DUF4142" ]
[ 11110 ]
1
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Bacteria", "Eukaryota", "metagenomes" ]
[ 11079, 20, 11 ]
3
[]
[]
0
true
Domain
Domain of unknown function DUF4142
Domain of unknown function DUF4142
DUF4142
5
IPR025420
25,420
Domain of unknown function DUF4143
DUF4143
Domain
19,392
false
false
This domain is often found C-terminal to an ATPase core domain.
[]
[]
[]
0
[ "PFAM" ]
[ "PF13635" ]
[ "DUF4143" ]
[ 19392 ]
1
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Archaea", "Bacteria", "Opisthokonta", "unclassified Caudoviricetes", "unclassified sequences" ]
[ 1253, 17461, 15, 6, 657 ]
5
[]
[]
0
true
Domain
Domain of unknown function DUF4143
Domain of unknown function DUF4143
DUF4143
4
IPR025421
25,421
Protein of unknown function DUF4148
DUF4148
Family
8,215
false
false
This protein family is functionally uncharacterised.
[]
[]
[]
0
[ "PFAM" ]
[ "PF13663" ]
[ "DUF4148" ]
[ 8215 ]
1
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Eukaryota", "Pseudomonadati", "metagenomes" ]
[ 9, 8191, 15 ]
3
[]
[]
0
true
Family
Protein of unknown function DUF4148
Protein of unknown function DUF4148
DUF4148
5
IPR025422
25,422
Transcription factor TGA like domain
TGA_domain
Domain
12,279
false
false
This entry represents a domain found in plant transcription factors, including TGA proteins and protein PERIANTHIA. In Arabidopsis thaliana, there are seven TGA paralogues (TGA 1-7), which are transcriptional activators that binds specifically to the DNA sequence 5'-TGACG-3' [ , ]. Another Arabidopsis thaliana protein ...
[ "GO:0043565", "GO:0006351" ]
[ "sequence-specific DNA binding", "DNA-templated transcription" ]
[ "molecular_function", "biological_process" ]
2
[ "PFAM", "PROFILE" ]
[ "PF14144", "PS51806" ]
[ "DOG1", "DOG1" ]
[ 11666, 12186 ]
2
[]
[]
[]
0
[ "7tac", "7tad", "7tae", "8gyz" ]
4
[ "PUB00053370", "PUB00066870", "PUB00066871" ]
[ "12897257", "12953119", "19395639" ]
[ "Salicylic acid and NPR1 induce the recruitment of trans-activating TGA factors to a defense gene promoter in Arabidopsis.", "The Arabidopsis NPR1 disease resistance protein is a novel cofactor that confers redox regulation of DNA binding activity to the basic domain/leucine zipper transcription factor TGA1.", ...
[ 2003, 2003, 2009 ]
3
[]
[]
0
0
null
[ "Eukaryota" ]
[ 12279 ]
1
[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]
[ 138, 50, 203 ]
3
true
Domain
Transcription factor TGA like domain
Transcription factor TGA like domain
TGA_domain
5
IPR025423
25,423
TMEM205-like
TMEM205-like
Domain
7,018
false
false
This entry represents a transmembrane domain found in TMEM205 from animals [ ], its homologue from yeast YPR098C and in uncharacterised bacterial sequences. This domain is functionally uncharacterised.
[]
[]
[]
0
[ "PFAM" ]
[ "PF13664" ]
[ "DUF4149" ]
[ 7018 ]
1
[]
[]
[]
0
[]
0
[ "PUB00154374" ]
[ "20589834" ]
[ "Elevated expression of TMEM205, a hypothetical membrane protein, is associated with cisplatin resistance." ]
[ 2010 ]
1
[]
[]
0
0
null
[ "Archaea", "Bacteria", "Eukaryota", "Riboviria sp.", "metagenomes" ]
[ 18, 2121, 4803, 1, 75 ]
5
[ "Arabidopsis thaliana", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "...
[ 14, 3, 3, 6, 2, 1, 9, 3, 1, 11 ]
10
true
Domain
TMEM205-like
TMEM205-like
TMEM205-like
5
IPR025424
25,424
YrhK domain
YrhK_domain
Domain
1,921
false
false
Bacillus subtilis YrhK protein is functionally uncharacterised. Its expression is under the control of the motility sigma factor sigma-D [ ]. This entry represents domain found in YrhK, where it comprises the whole length of the protein, and other sequences.
[]
[]
[]
0
[ "PFAM" ]
[ "PF14145" ]
[ "YrhK" ]
[ 1921 ]
1
[]
[]
[]
0
[]
0
[ "PUB00057339" ]
[ "20709900" ]
[ "Small genes under sporulation control in the Bacillus subtilis genome." ]
[ 2010 ]
1
[]
[]
0
0
null
[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences", "uncultured Caudovirales phage" ]
[ 24, 1591, 293, 12, 1 ]
5
[]
[]
0
true
Domain
YrhK domain
YrhK domain
YrhK_domain
7
IPR025426
25,426
Protein of unknown function DUF4305
DUF4305
Family
843
false
false
This family includes the Bacillus subtilis YdiK protein , which is functionally uncharacterised. This is not a homologue of Escherichia coli YdiK, which belongs to .
[]
[]
[]
0
[ "PFAM" ]
[ "PF14146" ]
[ "DUF4305" ]
[ 843 ]
1
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Bacillati", "bioreactor metagenome" ]
[ 842, 1 ]
2
[]
[]
0
true
Family
Protein of unknown function DUF4305
Protein of unknown function DUF4305
DUF4305
5
IPR025427
25,427
Protein of unknown function DUF4160
DUF4160
Family
4,371
false
false
The function of these proteins is not known.
[]
[]
[]
0
[ "PFAM" ]
[ "PF13711" ]
[ "DUF4160" ]
[ 4371 ]
1
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Bacteria", "Opisthokonta", "unclassified Caudoviricetes", "unclassified sequences" ]
[ 4270, 10, 6, 85 ]
4
[]
[]
0
true
Family
Protein of unknown function DUF4160
Protein of unknown function DUF4160
DUF4160
1
IPR025428
25,428
Sporulation protein YhaL
Spore_YhaL
Family
743
false
false
This family of proteins is involved in sporulation. In Bacillus subtilis its expression is regulated by the early mother-cell-specific transcription factor sigma-E [ ].
[]
[]
[]
0
[ "PFAM" ]
[ "PF14147" ]
[ "Spore_YhaL" ]
[ 743 ]
1
[]
[]
[]
0
[]
0
[ "PUB00034578" ]
[ "14523133" ]
[ "Identification of sporulation genes by genome-wide analysis of the sigmaE regulon of Bacillus subtilis." ]
[ 2003 ]
1
[]
[]
0
0
null
[ "Bacillales" ]
[ 743 ]
1
[]
[]
0
true
Family
Sporulation protein YhaL
Sporulation protein YhaL
Spore_YhaL
7
IPR025429
25,429
Domain of unknown function DUF4165
DUF4165
Domain
1,032
false
false
This presumed domain is functionally uncharacterised.
[]
[]
[]
0
[ "PFAM" ]
[ "PF13752" ]
[ "DUF4165" ]
[ 1032 ]
1
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Pseudomonadota" ]
[ 1032 ]
1
[]
[]
0
true
Domain
Domain of unknown function DUF4165
Domain of unknown function DUF4165
DUF4165
1
IPR025430
25,430
Domain of unknown function DUF4167
DUF4167
Domain
2,955
false
false
This presumed domain is functionally uncharacterised.
[]
[]
[]
0
[ "PFAM" ]
[ "PF13763" ]
[ "DUF4167" ]
[ 2955 ]
1
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Bacteria", "Eukaryota", "unclassified sequences" ]
[ 2907, 6, 42 ]
3
[]
[]
0
true
Domain
Domain of unknown function DUF4167
Domain of unknown function DUF4167
DUF4167
1
IPR025431
25,431
YhdB-like protein
YhdB-like
Family
637
false
false
The YhdB-like protein family includes the Bacillus subtilis YhdB protein , which is functionally uncharacterised. Proteins in this family are typically between 57 and 82 amino acids in length and contain two conserved sequence motifs: LMVRT and FLHAY.
[]
[]
[]
0
[ "PFAM" ]
[ "PF14148" ]
[ "YhdB" ]
[ 637 ]
1
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Bacillati" ]
[ 637 ]
1
[]
[]
0
true
Family
YhdB-like protein
YhdB-like protein
YhdB-like
1
IPR025432
25,432
YhfH-like protein
YhfH-like
Family
1,055
false
false
The YhfH-like protein family includes the Bacillus subtilis YhfH protein , which is functionally uncharacterised. Its expression is repressed by the Spx paralogue MgsR, which regulates genes involved in stress response [ ].
[]
[]
[]
0
[ "PFAM" ]
[ "PF14149" ]
[ "YhfH" ]
[ 1055 ]
1
[]
[]
[]
0
[]
0
[ "PUB00057340" ]
[ "18643936" ]
[ "The Spx paralogue MgsR (YqgZ) controls a subregulon within the general stress response of Bacillus subtilis." ]
[ 2008 ]
1
[]
[]
0
0
null
[ "Bacilli" ]
[ 1055 ]
1
[]
[]
0
true
Family
YhfH-like protein
YhfH-like protein
YhfH-like
7
IPR025434
25,434
YesK-like protein
YesK-like
Family
546
false
false
The YesK-like protein family includes the Bacillus subtilis YesK protein , which is functionally uncharacterised. Its expression is regulated by the sporulation-specific sigma factor sigma-E [ ].
[]
[]
[]
0
[ "PFAM" ]
[ "PF14150" ]
[ "YesK" ]
[ 546 ]
1
[]
[]
[]
0
[]
0
[ "PUB00057341" ]
[ "19061518" ]
[ "Transcriptional activity around bacterial cell death reveals molecular biomarkers for cell viability." ]
[ 2008 ]
1
[]
[]
0
0
null
[ "Bacillota" ]
[ 546 ]
1
[]
[]
0
true
Family
YesK-like protein
YesK-like protein
YesK-like
7
IPR025435
25,435
YfhD-like protein
YfhD-like
Family
1,059
false
false
The YfhD-like protein family includes the Bacillus subtilis YfhD protein , which is functionally uncharacterised. Its expression is regulated by the sporulation-specific sigma factor sigma-F [ ]. The proteins in this family contain a single completely conserved residue E that may be functionally important.
[]
[]
[]
0
[ "PFAM" ]
[ "PF14151" ]
[ "YfhD" ]
[ 1059 ]
1
[]
[]
[]
0
[]
0
[ "PUB00034417" ]
[ "12480901" ]
[ "Proteomics characterization of novel spore proteins of Bacillus subtilis." ]
[ 2002 ]
1
[]
[]
0
0
null
[ "Bacilli" ]
[ 1059 ]
1
[]
[]
0
true
Family
YfhD-like protein
YfhD-like protein
YfhD-like
9
IPR025436
25,436
Domain of unknown function DUF4179
DUF4179
Domain
4,511
false
false
This presumed domain is functionally uncharacterised.
[]
[]
[]
0
[ "PFAM" ]
[ "PF13786" ]
[ "DUF4179" ]
[ 4511 ]
1
[]
[]
[]
0
[ "3fbq" ]
1
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Bacteria", "Eukaryota", "metagenomes" ]
[ 4494, 2, 15 ]
3
[]
[]
0
true
Domain
Domain of unknown function DUF4179
Domain of unknown function DUF4179
DUF4179
8
IPR025437
25,437
YfhE-like protein
YfhE-like
Family
701
false
false
The YfhE-like protein family includes the Bacillus subtilis YfhE protein , which is functionally uncharacterised. Its expression may be regulated by the sigma factor sigma-B, which regulates the expression of stress-response proteins [ ]. The proteins in this family contain a conserved QEV sequence motif.
[]
[]
[]
0
[ "PFAM" ]
[ "PF14152" ]
[ "YfhE" ]
[ 701 ]
1
[]
[]
[]
0
[]
0
[ "PUB00057342" ]
[ "11532142" ]
[ "Genome-wide analysis of the general stress response in Bacillus subtilis." ]
[ 2001 ]
1
[]
[]
0
0
null
[ "Bacilli" ]
[ 701 ]
1
[]
[]
0
true
Family
YfhE-like protein
YfhE-like protein
YfhE-like
5
IPR025439
25,439
Spore coat protein CotO
Spore_coat_CotO
Family
735
false
false
Bacillus spores are protected by a protein shell consisting of over 50 different polypeptides, known as the coat. CotO has an important morphogenetic role in coat assembly, it is involved in the assembly of at least 5 different coat proteins including CotB, CotG, CotS, CotSA and CotW. It is likely to act at a late stag...
[]
[]
[]
0
[ "PFAM" ]
[ "PF14153" ]
[ "Spore_coat_CotO" ]
[ 735 ]
1
[]
[]
[]
0
[]
0
[ "PUB00057343" ]
[ "16321932" ]
[ "Characterization of the Bacillus subtilis spore morphogenetic coat protein CotO." ]
[ 2005 ]
1
[]
[]
0
0
null
[ "Bacillales" ]
[ 735 ]
1
[]
[]
0
true
Family
Spore coat protein CotO
Spore coat protein CotO
Spore_coat_CotO
8
IPR025440
25,440
Protein of unknown function DUF4306
DUF4306
Family
465
false
false
This family includes the Bacillus subtilis YjdJ protein , which is functionally uncharacterised. This is not a homologue of Escherichia coli YjdJ, which belongs to . The proteins in this family are found in bacteria and they are functionally uncharacterised.
[]
[]
[]
0
[ "PFAM" ]
[ "PF14154" ]
[ "DUF4306" ]
[ 465 ]
1
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[]
[ "IPR016508" ]
0
1
0
[ "Bacillales" ]
[ 465 ]
1
[]
[]
0
true
Family
Protein of unknown function DUF4306
Protein of unknown function DUF4306
DUF4306
8
IPR025441
25,441
Protein of unknown function DUF4181
DUF4181
Family
1,152
false
false
This protein family is functionally uncharacterised.
[]
[]
[]
0
[ "PFAM" ]
[ "PF13789" ]
[ "DUF4181" ]
[ 1152 ]
1
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Bacteria" ]
[ 1152 ]
1
[]
[]
0
true
Family
Protein of unknown function DUF4181
Protein of unknown function DUF4181
DUF4181
2
IPR025442
25,442
Domain of unknown function DUF4185
DUF4185
Domain
3,599
false
false
This presumed domain is functionally uncharacterised.
[]
[]
[]
0
[ "PFAM" ]
[ "PF13810" ]
[ "DUF4185" ]
[ 3599 ]
1
[]
[]
[]
0
[ "8an0", "8hhv", "8ic1" ]
3
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Bacteria", "Candidatus Bilamarchaeum dharawalense", "Caudoviricetes", "Eukaryota", "metagenomes" ]
[ 3245, 1, 10, 332, 11 ]
5
[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)" ]
[ 1 ]
1
true
Domain
Domain of unknown function DUF4185
Domain of unknown function DUF4185
DUF4185
5
IPR025443
25,443
Protein of unknown function DUF4307
DUF4307
Family
4,128
false
false
This family of proteins is functionally uncharacterised Proteins in this family are typically between 132 and 153 amino acids in length and contain a single completely conserved residue C that may be functionally important.
[]
[]
[]
0
[ "PFAM" ]
[ "PF14155" ]
[ "DUF4307" ]
[ 4128 ]
1
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Bacteria", "metagenomes" ]
[ 3979, 149 ]
2
[]
[]
0
true
Family
Protein of unknown function DUF4307
Protein of unknown function DUF4307
DUF4307
1
IPR025444
25,444
Monooxygenase af470-like
Monooxy_af470
Family
3,314
false
false
This family consists of proteins from bacteria and fungi. It includes monooxygenase af470 from Aspergillus fumigatus, which is part of the fma gene cluster that mediates the biosynthesis of fumagillin, a meroterpenoid with numerous biological activities [ ]. It has been suggested that af470 mediates the oxidative cleav...
[]
[]
[]
0
[ "PFAM" ]
[ "PF13826" ]
[ "Monooxy_af470-like" ]
[ 3314 ]
1
[]
[]
[]
0
[]
0
[ "PUB00081410", "PUB00081411" ]
[ "23488861", "24568283" ]
[ "The fumagillin biosynthetic gene cluster in Aspergillus fumigatus encodes a cryptic terpene cyclase involved in the formation of β-trans-bergamotene.", "Generation of complexity in fungal terpene biosynthesis: discovery of a multifunctional cytochrome P450 in the fumagillin pathway." ]
[ 2013, 2014 ]
2
[]
[]
0
0
null
[ "Bacteria", "Eukaryota", "Methanobacteriati", "metagenomes" ]
[ 2151, 1040, 101, 22 ]
4
[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)" ]
[ 1 ]
1
true
Family
Monooxygenase af470-like
Monooxygenase af470-like
Monooxy_af470
6
IPR025445
25,445
Protein of unknown function DUF4191
DUF4191
Family
4,612
false
false
This protein family is functionally uncharacterised.
[]
[]
[]
0
[ "PFAM" ]
[ "PF13829" ]
[ "DUF4191" ]
[ 4612 ]
1
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Bacteria", "Rhynchospora breviuscula", "metagenomes" ]
[ 4467, 1, 144 ]
3
[]
[]
0
true
Family
Protein of unknown function DUF4191
Protein of unknown function DUF4191
DUF4191
9
IPR025446
25,446
Antirepressor AbbA
Antirep_AbbA
Family
277
false
false
AbbA inactivates the repressor AbrB, which represses genes switched on during the transition from the exponential to the stationary phase of growth. It binds to AbrB and prevents it from binding to DNA [ ].
[]
[]
[]
0
[ "PFAM" ]
[ "PF14156" ]
[ "AbbA_antirepres" ]
[ 277 ]
1
[]
[]
[]
0
[ "2lzf" ]
1
[ "PUB00057344" ]
[ "18840696" ]
[ "Parallel pathways of repression and antirepression governing the transition to stationary phase in Bacillus subtilis." ]
[ 2008 ]
1
[]
[]
0
0
null
[ "Bacillales" ]
[ 277 ]
1
[]
[]
0
true
Family
Antirepressor AbbA
Antirepressor AbbA
Antirep_AbbA
1
IPR025447
25,447
Protein of unknown function DUF4192
DUF4192
Family
4,936
false
false
This protein family is functionally uncharacterised.
[]
[]
[]
0
[ "PFAM" ]
[ "PF13830" ]
[ "DUF4192" ]
[ 4936 ]
1
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Bacteria", "metagenomes", "uncultured Caudovirales phage" ]
[ 4816, 119, 1 ]
3
[]
[]
0
true
Family
Protein of unknown function DUF4192
Protein of unknown function DUF4192
DUF4192
9
IPR025448
25,448
YmzC-like protein
YmzC-like
Family
246
false
false
The YmzC-like protein family includes the Bacillus subtilis YmzC protein , which is functionally uncharacterised. The proteins in this family contain a conserved ELR sequence motif.
[]
[]
[]
0
[ "PFAM" ]
[ "PF14157" ]
[ "YmzC" ]
[ 246 ]
1
[]
[]
[]
0
[ "3kvp" ]
1
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Bacillus" ]
[ 246 ]
1
[]
[]
0
true
Family
YmzC-like protein
YmzC-like protein
YmzC-like
7
IPR025449
25,449
Wadjet protein JetB
JetB
Family
3,751
false
false
This family includes Wadjet protein JetB, a component of anti plasmid transformation system Wadjet type I, composed of JetA, JetB, JetC and JetD. Expression of Wadjet type I in B.subtilis (strain BEST7003) reduces the transformation efficiency of plasmid pHCMC05 [ ].
[]
[]
[]
0
[ "PFAM" ]
[ "PF13835" ]
[ "DUF4194" ]
[ 3751 ]
1
[]
[]
[]
0
[ "8as8", "8bfn", "8dk1", "8dk2", "8q72", "9qxr", "9qxs", "9qxt", "9qxu", "9qxv", "9qxx" ]
11
[ "PUB00097806" ]
[ "29371424" ]
[ "Systematic discovery of antiphage defense systems in the microbial pangenome." ]
[ 2018 ]
1
[]
[]
0
0
null
[ "Bacteria", "Methanosarcinales", "Opisthokonta", "unclassified sequences" ]
[ 3694, 4, 2, 51 ]
4
[]
[]
0
true
Family
Wadjet protein JetB
Wadjet protein JetB
JetB
2
IPR025450
25,450
YndJ-like protein
YndJ-like
Family
960
false
false
The YndJ-like protein family includes the Bacillus subtilis YndJ protein , which is functionally uncharacterised. The proteins in this family contain two completely conserved G residues that may be functionally important.
[]
[]
[]
0
[ "PFAM" ]
[ "PF14158" ]
[ "YndJ" ]
[ 960 ]
1
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Bacteria", "Halobacteria" ]
[ 905, 55 ]
2
[]
[]
0
true
Family
YndJ-like protein
YndJ-like protein
YndJ-like
6
IPR025451
25,451
Domain of unknown function DUF4211
DUF4211
Domain
4,758
false
false
This presumed domain is functionally uncharacterised.
[]
[]
[]
0
[ "PFAM" ]
[ "PF13926" ]
[ "DUF4211" ]
[ 4758 ]
1
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Eukaryota", "bird metagenome" ]
[ 4757, 1 ]
2
[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]
[ 11, 5, 17, 6, 1, 10, 1 ]
7
true
Domain
Domain of unknown function DUF4211
Domain of unknown function DUF4211
DUF4211
6
IPR025452
25,452
Domain of unknown function DUF4218
DUF4218
Domain
9,931
false
false
This presumed domain is functionally uncharacterised.
[]
[]
[]
0
[ "PFAM" ]
[ "PF13960" ]
[ "DUF4218" ]
[ 9931 ]
1
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Eukaryota", "Undibacterium" ]
[ 9929, 2 ]
2
[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]
[ 27, 586, 8 ]
3
true
Domain
Domain of unknown function DUF4218
Domain of unknown function DUF4218
DUF4218
1
IPR025453
25,453
Protein of unknown function DUF4309
DUF4309
Family
1,080
false
false
This family includes the Bacillus subtilis YjgB protein , which is functionally uncharacterised. This is not a homologue of Escherichia coli YjgB, . Expression of B. subtilis YjgB is regulated by the alternative transcription factor sigma-B [ ].
[]
[]
[]
0
[ "PFAM" ]
[ "PF14172" ]
[ "DUF4309" ]
[ 1080 ]
1
[]
[]
[]
0
[ "4ygt" ]
1
[ "PUB00057342" ]
[ "11532142" ]
[ "Genome-wide analysis of the general stress response in Bacillus subtilis." ]
[ 2001 ]
1
[]
[]
0
0
null
[ "Bacteria", "bioreactor metagenome" ]
[ 1079, 1 ]
2
[]
[]
0
true
Family
Protein of unknown function DUF4309
Protein of unknown function DUF4309
DUF4309
1
IPR025454
25,454
Protein of unknown function DUF4275
DUF4275
Family
493
false
false
This protein family is functionally uncharacterised.
[]
[]
[]
0
[ "PFAM" ]
[ "PF14101" ]
[ "DUF4275" ]
[ 493 ]
1
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Bacteria", "Candidatus Methanoplasma termitum", "metagenomes" ]
[ 486, 1, 6 ]
3
[]
[]
0
true
Family
Protein of unknown function DUF4275
Protein of unknown function DUF4275
DUF4275
6
IPR025455
25,455
Protein of unknown function DUF4276
DUF4276
Family
2,239
false
false
This family of prokaryotic proteins is uncharacterised, including Mad4, part of the methylation-associated defence system (MADS) [ ]. There is a single completely conserved residue E that may be functionally important.
[]
[]
[]
0
[ "PFAM" ]
[ "PF14103" ]
[ "DUF4276" ]
[ 2239 ]
1
[]
[]
[]
0
[]
0
[ "PUB00159606" ]
[ "39094583" ]
[ "The bacterial defense system MADS interacts with CRISPR-Cas to limit phage infection and escape." ]
[ 2024 ]
1
[]
[]
0
0
null
[ "Bacteria", "Metazoa", "Methanomicrobia", "Myoviridae sp. ctTrm2", "metagenomes" ]
[ 2159, 2, 33, 1, 44 ]
5
[]
[]
0
true
Family
Protein of unknown function DUF4276
Protein of unknown function DUF4276
DUF4276
3
IPR025456
25,456
Protein of unknown function DUF4310
DUF4310
Family
1,220
false
false
The proteins in this family are functionally uncharacterised.
[]
[]
[]
0
[ "PFAM", "NCBIFAM" ]
[ "PF14187", "TIGR03579" ]
[ "DUF4310", "EF_0833" ]
[ 1220, 1174 ]
2
[ "GP" ]
[ "GenProp0798" ]
[ "GP:GenProp0798" ]
1
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Bacteria", "Methanosarcina mazei", "bioreactor metagenome" ]
[ 1218, 1, 1 ]
3
[]
[]
0
true
Family
Protein of unknown function DUF4310
Protein of unknown function DUF4310
DUF4310
4
IPR025457
25,457
Domain of unknown function DUF4277
DUF4277
Domain
1,720
false
false
This presumed domain is functionally uncharacterised. There is a conserved NGLGF sequence motif.
[]
[]
[]
0
[ "PFAM" ]
[ "PF14104" ]
[ "DUF4277" ]
[ 1720 ]
1
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Bacteria", "Methanobacteriati", "Oedothorax gibbosus", "ecological metagenomes" ]
[ 1455, 214, 1, 50 ]
4
[]
[]
0
true
Domain
Domain of unknown function DUF4277
Domain of unknown function DUF4277
DUF4277
4
IPR025460
25,460
Protein of unknown function DUF4280
DUF4280
Family
2,814
false
false
This family of proteins is functionally uncharacterised. There is a single completely conserved residue C that may be functionally important.
[]
[]
[]
0
[ "PFAM" ]
[ "PF14107" ]
[ "DUF4280" ]
[ 2814 ]
1
[]
[]
[]
0
[ "9jg8", "9jg9" ]
2
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Bacteria", "Eukaryota", "Myoviridae sp. ctB7y8", "ecological metagenomes" ]
[ 2796, 9, 1, 8 ]
4
[]
[]
0
true
Family
Protein of unknown function DUF4280
Protein of unknown function DUF4280
DUF4280
2
IPR025462
25,462
Protein of unknown function DUF4313
DUF4313
Family
685
false
false
The proteins in this family are functionally uncharacterised.
[]
[]
[]
0
[ "PFAM" ]
[ "PF14190" ]
[ "DUF4313" ]
[ 685 ]
1
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Bacteria", "organismal metagenomes", "unclassified Caudoviricetes" ]
[ 669, 14, 2 ]
3
[]
[]
0
true
Family
Protein of unknown function DUF4313
Protein of unknown function DUF4313
DUF4313
8
IPR025463
25,463
Domain of unknown function DUF4314
DUF4314
Domain
1,131
false
false
This presumed domain has not been functionally characterised.
[]
[]
[]
0
[ "PFAM" ]
[ "PF14192" ]
[ "DUF4314" ]
[ 1131 ]
1
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Bacteria", "Methanobrevibacter ruminantium (strain ATCC 35063 / DSM 1093 / JCM 13430 / OCM 146 / M1)", "Viruses", "unclassified sequences" ]
[ 1040, 1, 40, 50 ]
4
[]
[]
0
true
Domain
Domain of unknown function DUF4314
Domain of unknown function DUF4314
DUF4314
3
IPR025464
25,464
Protein of unknown function DUF4315
DUF4315
Family
1,396
false
false
This family of proteins is functionally uncharacterised.
[]
[]
[]
0
[ "PFAM" ]
[ "PF14193" ]
[ "DUF4315" ]
[ 1396 ]
1
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Bacteria", "Glossina morsitans morsitans", "Siphoviridae sp. ctoWO12", "unclassified sequences" ]
[ 1364, 1, 1, 30 ]
4
[]
[]
0
true
Family
Protein of unknown function DUF4315
Protein of unknown function DUF4315
DUF4315
7
IPR025466
25,466
Protein of unknown function DUF4317
DUF4317
Family
1,649
false
false
The proteins in this family are functionally uncharacterised. There is a single completely conserved residue P that may be functionally important.
[]
[]
[]
0
[ "PFAM" ]
[ "PF14199" ]
[ "DUF4317" ]
[ 1649 ]
1
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Bacteria", "Batrachochytrium dendrobatidis (strain JAM81 / FGSC 10211)", "Viruses", "metagenomes" ]
[ 1626, 1, 9, 13 ]
4
[]
[]
0
true
Family
Protein of unknown function DUF4317
Protein of unknown function DUF4317
DUF4317
3
IPR025467
25,467
Protein of unknown function DUF4318
DUF4318
Family
194
false
false
This family of proteins is functionally uncharacterised. Proteins in this family contain a single completely conserved residue F that may be functionally important.
[]
[]
[]
0
[ "PFAM" ]
[ "PF14201" ]
[ "DUF4318" ]
[ 194 ]
1
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Bacillota", "bioreactor metagenome" ]
[ 193, 1 ]
2
[]
[]
0
true
Family
Protein of unknown function DUF4318
Protein of unknown function DUF4318
DUF4318
6
IPR025468
25,468
Putative transposon-transfer assisting protein
TTRAP
Family
1,087
false
false
TTRAP is a family of small bacterial proteins largely from Clostrium difficile. From comparative and other structural studies of the PDB: , , it has been suggested that this family is required for interacting with other proteins in order to facilitate the transfer of the transposon CTn4 between different bacterial spec...
[]
[]
[]
0
[ "PFAM" ]
[ "PF14203" ]
[ "TTRAP" ]
[ 1087 ]
1
[]
[]
[]
0
[ "2l7k" ]
1
[ "PUB00075684" ]
[ "24048810" ]
[ "Solution NMR structure of CD1104B from pathogenic Clostridium difficile reveals a distinct α-helical architecture and provides first structural representative of protein domain family PF14203." ]
[ 2013 ]
1
[]
[]
0
0
null
[ "Bacteria", "metagenomes" ]
[ 1070, 17 ]
2
[]
[]
0
true
Family
Putative transposon-transfer assisting protein
Putative transposon-transfer assisting protein
TTRAP
9
IPR025469
25,469
Protein of unknown function DUF4320
DUF4320
Family
511
false
false
This family is functionally uncharacterised. There are two completely conserved residues (G and Y) that may be functionally important.
[]
[]
[]
0
[ "PFAM" ]
[ "PF14208" ]
[ "DUF4320" ]
[ 511 ]
1
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Bacteria", "metagenomes" ]
[ 487, 24 ]
2
[]
[]
0
true
Family
Protein of unknown function DUF4320
Protein of unknown function DUF4320
DUF4320
3
IPR025470
25,470
Protein of unknown function DUF4321
DUF4321
Family
1,076
false
false
The proteins in this family are functionally uncharacterised.
[]
[]
[]
0
[ "PFAM" ]
[ "PF14209" ]
[ "DUF4321" ]
[ 1076 ]
1
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Bacteria", "ecological metagenomes" ]
[ 1033, 43 ]
2
[]
[]
0
true
Family
Protein of unknown function DUF4321
Protein of unknown function DUF4321
DUF4321
1
IPR025471
25,471
Domain of unknown function DUF4322
DUF4322
Domain
247
false
false
This presumed domain is functionally uncharacterised. It has a conserved QTV sequence motif.
[]
[]
[]
0
[ "PFAM" ]
[ "PF14210" ]
[ "DUF4322" ]
[ 247 ]
1
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Sulfolobaceae" ]
[ 247 ]
1
[]
[]
0
true
Domain
Domain of unknown function DUF4322
Domain of unknown function DUF4322
DUF4322
7
IPR025474
25,474
Domain of unknown function DUF4325
DUF4325
Domain
1,927
false
false
This domain is functionally uncharacterised. It is found predominantly in bacteria but also some archaea.
[]
[]
[]
0
[ "PFAM" ]
[ "PF14213" ]
[ "DUF4325" ]
[ 1927 ]
1
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Archaea", "Bacteria", "Metazoa", "Viruses", "metagenomes" ]
[ 61, 1813, 2, 7, 44 ]
5
[]
[]
0
true
Domain
Domain of unknown function DUF4325
Domain of unknown function DUF4325
DUF4325
3
IPR025475
25,475
Domain of unknown function DUF4326
DUF4326
Domain
2,372
false
false
This entry represents a domain that is functionally uncharacterised. Proteins in this family have two completely conserved residues (P and C) that may be functionally important. This domain covers the whole length of the protein in some sequences and is found C-terminal to in a small group of proteobacterial proteins.
[]
[]
[]
0
[ "PFAM" ]
[ "PF14216" ]
[ "DUF4326" ]
[ 2372 ]
1
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Bacteria", "Eukaryota", "Methanobacteriota", "Viruses", "metagenomes" ]
[ 1247, 297, 27, 688, 113 ]
5
[]
[]
0
true
Domain
Domain of unknown function DUF4326
Domain of unknown function DUF4326
DUF4326
8
IPR025476
25,476
Helitron helicase-like domain
Helitron_helicase-like
Domain
20,490
false
false
This domain is found in Helitrons, widespread eukaryotic DNA transposons that have significantly contributed to genome variability and evolution, as they perform a distinctive, replicative rolling-circle mechanism, which often mobilizes adjacent genes [ , ]. Helitron transposases contain a single-stranded DNA (ssDNA)-s...
[]
[]
[]
0
[ "PFAM" ]
[ "PF14214" ]
[ "Helitron_like_N" ]
[ 20490 ]
1
[]
[]
[]
0
[ "7lcc" ]
1
[ "PUB00057345", "PUB00153358" ]
[ "19622734", "34403695" ]
[ "Structure-based discovery and description of plant and animal Helitrons.", "The large bat Helitron DNA transposase forms a compact monomeric assembly that buries and protects its covalently bound 5'-transposon end." ]
[ 2009, 2021 ]
2
[]
[]
0
0
null
[ "Candidatus Erwinia dacicola", "Eukaryota", "organismal metagenomes" ]
[ 1, 20487, 2 ]
3
[ "Arabidopsis thaliana", "Danio rerio", "Oryza sativa subsp. japonica", "Zea mays" ]
[ 19, 28, 94, 664 ]
4
true
Domain
Helitron helicase-like domain
Helitron helicase-like domain
Helitron_helicase-like
7
IPR025477
25,477
Protein of unknown function DUF4327
DUF4327
Family
793
false
false
This family of bacterial proteins is functionally uncharacterised
[]
[]
[]
0
[ "PFAM" ]
[ "PF14217" ]
[ "DUF4327" ]
[ 793 ]
1
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Cyanobacteriota" ]
[ 793 ]
1
[]
[]
0
true
Family
Protein of unknown function DUF4327
Protein of unknown function DUF4327
DUF4327
3
IPR025478
25,478
Circadian oscillating protein COP23
COP23
Family
1,055
false
false
This family includes the circadian oscillating protein COP23 from Cyanothece sp. (strain PCC 8801), . The levels of this peripheral membrane protein display a circadian oscillation [ ].
[]
[]
[]
0
[ "PFAM" ]
[ "PF14218" ]
[ "COP23" ]
[ 1055 ]
1
[]
[]
[]
0
[]
0
[ "PUB00057346" ]
[ "8818292" ]
[ "Regulation and molecular structure of a circadian oscillating protein located in the cell membrane of the prokaryote Synechococcus RF-1." ]
[ 1996 ]
1
[]
[]
0
0
null
[ "Cyanobacteriota" ]
[ 1055 ]
1
[]
[]
0
true
Family
Circadian oscillating protein COP23
Circadian oscillating protein COP23
COP23
1
IPR025479
25,479
Domain of unknown function DUF4329
DUF4329
Domain
992
false
false
This domain is functionally uncharacterised. It contains a single completely conserved residue D and a highly conserved HTH motif which may be functionally important.
[]
[]
[]
0
[ "PFAM" ]
[ "PF14220" ]
[ "DUF4329" ]
[ 992 ]
1
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Bacteria", "Opisthokonta", "Vibrio phage Vp_R1", "metagenomes" ]
[ 981, 5, 1, 5 ]
4
[ "Escherichia coli (strain K12)" ]
[ 2 ]
1
true
Domain
Domain of unknown function DUF4329
Domain of unknown function DUF4329
DUF4329
7
IPR025480
25,480
Protein of unknown function DUF4330
DUF4330
Family
829
false
false
This family of proteins is functionally uncharacterised. Proteins in this family have a single completely conserved residue G that may be functionally important. Some members are annotated as Pyruvate/2-oxoglutarate dehydrogenase complex,dihydrolipoamide dehydrogenase (E3) component.
[]
[]
[]
0
[ "PFAM" ]
[ "PF14221" ]
[ "DUF4330" ]
[ 829 ]
1
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Bacteria", "Halobacteriales", "Paulinella", "ecological metagenomes" ]
[ 640, 174, 2, 13 ]
4
[]
[]
0
true
Family
Protein of unknown function DUF4330
Protein of unknown function DUF4330
DUF4330
9
IPR025483
25,483
Lipase, eukaryotic
Lipase_euk
Family
11,379
false
false
This entry represents a family of eukaryotic lipases, including gastric triacylglycerol lipase [ ], lysosomal acid lipase [ ] and triacylglycerol lipase 1 [ ].
[ "GO:0016788" ]
[ "hydrolase activity, acting on ester bonds" ]
[ "molecular_function" ]
1
[ "PIRSF" ]
[ "PIRSF000862" ]
[ "Steryl_ester_lip" ]
[ 11379 ]
1
[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]
[ "3.1.1", "R-HSA-192456", "R-HSA-6809371", "R-HSA-8964038", "R-MMU-192456", "R-MMU-6809371", "R-MMU-8964038", "R-RNO-192456", "R-RNO-8964038", "R-SPO-192456", "R-SPO-6809371" ]
[ "EC:3.1.1", "REACTOME:R-HSA-192456", "REACTOME:R-HSA-6809371", "REACTOME:R-HSA-8964038", "REACTOME:R-MMU-192456", "REACTOME:R-MMU-6809371", "REACTOME:R-MMU-8964038", "REACTOME:R-RNO-192456", "REACTOME:R-RNO-8964038", "REACTOME:R-SPO-192456", "REACTOME:R-SPO-6809371" ]
11
[ "1hlg", "1k8q", "6v7n" ]
3
[ "PUB00057348", "PUB00057349", "PUB00057350" ]
[ "3304425", "8576647", "16226259" ]
[ "Molecular cloning of a human gastric lipase and expression of the enzyme in yeast.", "Cloning of rat lysosomal acid lipase cDNA and identification of the mutation in the rat model of Wolman's disease.", "Identification and characterization of a triacylglycerol lipase in Arabidopsis homologous to mammalian acid...
[ 1987, 1995, 2005 ]
3
[]
[]
0
0
null
[ "Eukaryota" ]
[ 11379 ]
1
[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)", "Zea mays" ]
[ 9, 7, 1, 34, 11, 13, 10, 14, 1, 10 ]
10
true
Family
Lipase, eukaryotic
Lipase, eukaryotic
Lipase_euk
2
IPR025484
25,484
Domain of unknown function DUF4376
DUF4376
Domain
3,119
false
false
The function of this domain is unknown.
[]
[]
[]
0
[ "PFAM" ]
[ "PF14301" ]
[ "DUF4376" ]
[ 3119 ]
1
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Bacteria", "Eukaryota", "Viruses", "metagenomes" ]
[ 2911, 6, 193, 9 ]
4
[]
[]
0
true
Domain
Domain of unknown function DUF4376
Domain of unknown function DUF4376
DUF4376
5
IPR025485
25,485
Domain of unknown function DUF4377
DUF4377
Domain
2,589
false
false
The function of this domain is unknown.
[]
[]
[]
0
[ "PFAM" ]
[ "PF14302" ]
[ "DUF4377" ]
[ 2589 ]
1
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Archaea", "Bacteria", "Opisthokonta", "metagenomes" ]
[ 12, 2550, 6, 21 ]
4
[]
[]
0
true
Domain
Domain of unknown function DUF4377
Domain of unknown function DUF4377
DUF4377
5
IPR025486
25,486
LONGIFOLIA 1/2-like, C-terminal domain
LNG1/2-like_C
Domain
14,079
false
false
This entry represents the C-terminal domain in Centrosome-associated protein 350 (Cep350), Protein TRM32 and Protein LONGIFOLIA 1/2 found in eukaryotes. This domain contains a helical fold. Cep350 plays an essential role in centriole growth by stabilising a procentriolar seed composed of at least, SASS6 and CPAP. Requi...
[]
[]
[]
0
[ "PFAM" ]
[ "PF14309" ]
[ "DUF4378" ]
[ 14079 ]
1
[]
[]
[]
0
[]
0
[ "PUB00069164", "PUB00078481", "PUB00095561", "PUB00162468", "PUB00162469" ]
[ "15615782", "17038516", "22286137", "19052644", "28659385" ]
[ "Activity and subcellular compartmentalization of peroxisome proliferator-activated receptor alpha are altered by the centrosome-associated protein CAP350.", "LONGIFOLIA1 and LONGIFOLIA2, two homologous genes, regulate longitudinal cell elongation in Arabidopsis.", "The Arabidopsis TRM1-TON1 interaction reveals...
[ 2005, 2006, 2012, 2008, 2017 ]
5
[]
[]
0
0
null
[ "Eukaryota" ]
[ 14079 ]
1
[ "Arabidopsis thaliana", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]
[ 138, 4, 1, 73, 5, 154 ]
6
true
Domain
LONGIFOLIA 1/2-like, C-terminal domain
LONGIFOLIA 1/2-like, C-terminal domain
LNG1/2-like_C
2
IPR025487
25,487
Treble clef zinc finger domain
DUF4379
Domain
1,808
false
false
This domain is found in bacteria, eukaryotes and viruses, and is approximately 60 amino acids in length. It contains a CXXCXH motif and a CPXC motif. It is predicted to adopt a treble clef fold. Some members have the second probable zinc binding residue replaced by histidine. The specific function of this domain is yet...
[]
[]
[]
0
[ "PFAM" ]
[ "PF14311" ]
[ "DUF4379" ]
[ 1808 ]
1
[]
[]
[]
0
[ "6hiv", "6hiw", "6hiy", "6sga", "6sgb", "6yxx", "7ane", "7aor", "7pua", "7pub", "9hny" ]
11
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "metagenomes" ]
[ 9, 1083, 495, 154, 67 ]
5
[]
[]
0
true
Domain
Treble clef zinc finger domain
Treble clef zinc finger domain
DUF4379
7
IPR025488
25,488
Protein of unknown function DUF4380
DUF4380
Family
334
false
false
This family of proteins is functionally uncharacterised. There are two completely conserved residues (G and E) that may be functionally important.
[]
[]
[]
0
[ "PFAM" ]
[ "PF14315" ]
[ "DUF4380" ]
[ 334 ]
1
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Bacteria", "Dinophyceae", "unclassified sequences" ]
[ 329, 3, 2 ]
3
[]
[]
0
true
Family
Protein of unknown function DUF4380
Protein of unknown function DUF4380
DUF4380
8
IPR025490
25,490
RQC P-site tRNA stabilizing factor
RqcP
Family
4,759
false
false
This entry represents the RQC P-site tRNA stabilizing factor (RqcP) found mainly in bacteria. RqcP is a component of the ribosome quality control system, a ribosome-associated complex that mediates the extraction of incompletely synthesised nascent chains from stalled ribosomes and their subsequent degradation [ , ]. R...
[]
[]
[]
0
[ "HAMAP", "PIRSF" ]
[ "MF_00871", "PIRSF038881" ]
[ "RqcP", "RNAbp_HP1423" ]
[ 4375, 4738 ]
2
[]
[]
[]
0
[ "2k6p", "7aqc", "7as8", "7asa", "7ope" ]
5
[ "PUB00155443", "PUB00155444", "PUB00155445" ]
[ "33259810", "33259811", "34255840" ]
[ "Structural Basis for Bacterial Ribosome-Associated Quality Control by RqcH and RqcP.", "Mimicry of Canonical Translation Elongation Underlies Alanine Tail Synthesis in RQC.", "RqcH and RqcP catalyze processive poly-alanine synthesis in a reconstituted ribosome-associated quality control system." ]
[ 2021, 2021, 2021 ]
3
[]
[]
0
0
null
[ "Bacteria", "Eukaryota", "metagenomes" ]
[ 4708, 2, 49 ]
3
[]
[]
0
true
Family
RQC P-site tRNA stabilizing factor
RQC P-site tRNA stabilizing factor
RqcP
4
IPR025491
25,491
Domain of unknown function DUF4382
DUF4382
Domain
2,973
false
false
The function of this domain is unknown.
[]
[]
[]
0
[ "PFAM" ]
[ "PF14321" ]
[ "DUF4382" ]
[ 2973 ]
1
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Archaea", "Bacteria", "Eukaryota", "ecological metagenomes" ]
[ 420, 2488, 2, 63 ]
4
[]
[]
0
true
Domain
Domain of unknown function DUF4382
Domain of unknown function DUF4382
DUF4382
6
IPR025493
25,493
Domain of unknown function DUF4384
DUF4384
Domain
2,445
false
false
This presumed domain is functionally uncharacterised.
[]
[]
[]
0
[ "PFAM" ]
[ "PF14326" ]
[ "DUF4384" ]
[ 2445 ]
1
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Bacteria", "Candidatus Methanogaster sp.", "Eukaryota", "ecological metagenomes" ]
[ 2391, 1, 10, 43 ]
4
[]
[]
0
true
Domain
Domain of unknown function DUF4384
Domain of unknown function DUF4384
DUF4384
3
IPR025494
25,494
Protein of unknown function DUF4385
DUF4385
Family
2,262
false
false
This family of proteins is functionally uncharacterised.
[]
[]
[]
0
[ "PFAM" ]
[ "PF14328" ]
[ "DUF4385" ]
[ 2262 ]
1
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Bacteria", "Eukaryota", "Halobacteriales", "Viruses", "marine metagenome" ]
[ 1653, 515, 70, 23, 1 ]
5
[]
[]
0
true
Family
Protein of unknown function DUF4385
Protein of unknown function DUF4385
DUF4385
3
IPR025496
25,496
Protein of unknown function DUF4387
DUF4387
Domain
2,040
false
false
This domain is functionally uncharacterised. There is a conserved RSKN sequence motif.
[]
[]
[]
0
[ "PFAM" ]
[ "PF14330" ]
[ "DUF4387" ]
[ 2040 ]
1
[]
[]
[]
0
[ "9erq", "9evf" ]
2
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Bacteria", "Eukaryota", "Methanobacteriota", "metagenomes" ]
[ 1268, 738, 7, 27 ]
4
[]
[]
0
true
Domain
Protein of unknown function DUF4387
Protein of unknown function DUF4387
DUF4387
4
IPR025497
25,497
PatA-like, N-terminal
PatA-like_N
Domain
4,362
false
false
This entry represents the N-terminal domain of Protein PatA from Nostoc sp. and similar bacterial proteins. PatA controls heterocyst pattern formation. It is required for the differentiation of intercalary heterocysts but not for terminal heterocysts [ , , ]. This domain was previously known as DUF4388.
[]
[]
[]
0
[ "PFAM" ]
[ "PF14332" ]
[ "PatA_N" ]
[ 4362 ]
1
[]
[]
[]
0
[]
0
[ "PUB00014608", "PUB00075466", "PUB00075467" ]
[ "1608976", "20622060", "20639317" ]
[ "The patA gene product, which contains a region similar to CheY of Escherichia coli, controls heterocyst pattern formation in the cyanobacterium Anabaena 7120.", "Transcriptional regulation of the heterocyst patterning gene patA from Anabaena sp. strain PCC 7120.", "NtcA regulates patA expression in Anabaena sp...
[ 1992, 2010, 2010 ]
3
[]
[]
0
0
null
[ "Bacteria", "Daphnia magna", "ecological metagenomes" ]
[ 4302, 1, 59 ]
3
[]
[]
0
true
Domain
PatA-like, N-terminal
PatA-like, N-terminal
PatA-like_N
9
IPR025498
25,498
Protein of unknown function DUF4389
DUF4389
Family
3,020
false
false
This family of proteins is functionally uncharacterised. There is a single completely conserved residue R that may be functionally important.
[]
[]
[]
0
[ "PFAM" ]
[ "PF14333" ]
[ "DUF4389" ]
[ 3020 ]
1
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Archaea", "Bacteria", "Geodia barretti", "metagenomes" ]
[ 32, 2843, 1, 144 ]
4
[]
[]
0
true
Family
Protein of unknown function DUF4389
Protein of unknown function DUF4389
DUF4389
3
IPR025499
25,499
Pectin degradation protein KdgF
KdgF
Family
3,532
false
false
This entry represents pectin degradation protein KdgF, which may have a role in pathogenicity [ ].
[]
[]
[]
0
[ "PIRSF" ]
[ "PIRSF029883" ]
[ "KdgF" ]
[ 3532 ]
1
[]
[]
[]
0
[ "2pfw", "5fpx", "5fpz", "5fq0" ]
4
[ "PUB00014561" ]
[ "1766386" ]
[ "Analysis of an Erwinia chrysanthemi gene cluster involved in pectin degradation." ]
[ 1991 ]
1
[]
[]
0
0
null
[ "Archaea", "Bacteria", "Pentapetalae", "metagenomes" ]
[ 48, 3446, 2, 36 ]
4
[]
[]
0
true
Family
Pectin degradation protein KdgF
Pectin degradation protein KdgF
KdgF
2
IPR025501
25,501
ATP binding protein MinD/FleN
MinD_FleN
Family
17,020
false
false
This entry represents an ATPase that includes both a MinD-type, and FleN-type. MinD is a multifunctional cell division protein that guides correct placement of the septum. In Escherichia coli, the cell division site is determined by the cooperative activity of min operon products MinC, MinD, and MinE [ ]. MinD is a mem...
[]
[]
[]
0
[ "PIRSF" ]
[ "PIRSF003092" ]
[ "MinD" ]
[ 17020 ]
1
[]
[]
[]
0
[ "1g3q", "1g3r", "1hyq", "1ion", "3q9l", "3r9i", "3r9j", "4rz2", "4rz3", "4v02", "4v03", "5j1j", "5jvf", "6riq", "7ejw", "8pb9" ]
16
[ "PUB00014907", "PUB00014908", "PUB00019559", "PUB00093709" ]
[ "11566131", "15126639", "10629180", "22581773" ]
[ "The three-dimensional structure of septum site-determining protein MinD from Pyrococcus horikoshii OT3 in complex with Mg-ADP.", "Chloroplast division site placement requires dimerization of the ARC11/AtMinD1 protein in Arabidopsis.", "fleN, a gene that regulates flagellar number in Pseudomonas aeruginosa.", ...
[ 2001, 2004, 2000, 2012 ]
4
[]
[ "IPR010223" ]
0
1
0
[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]
[ 286, 16238, 354, 142 ]
4
[ "Escherichia coli (strain K12)", "Oryza sativa subsp. japonica" ]
[ 1, 2 ]
2
true
Family
ATP binding protein MinD/FleN
ATP binding protein MinD/FleN
MinD_FleN
9
IPR025502
25,502
TldD
TldD
Family
11,407
false
false
The letD gene product of the F plasmid acts to inhibit partitioning of chromosomal DNA and cell division by inhibiting the DNA gyrase. TldD, together with TldE (also known as PmbA) and ZfiA, are host proteins that modulate the activity of the DNA Gyrase along with letD [ ]. It has been proposed that the zfiA gene produ...
[ "GO:0008237", "GO:0006508" ]
[ "metallopeptidase activity", "proteolysis" ]
[ "molecular_function", "biological_process" ]
2
[ "PIRSF" ]
[ "PIRSF004919" ]
[ "TldD" ]
[ 11407 ]
1
[]
[]
[]
0
[ "5nj5", "5nj9", "5nja", "5njb", "5njc", "5njf" ]
6
[ "PUB00003357" ]
[ "8604133" ]
[ "Evidence for involvement of Escherichia coli genes pmbA, csrA and a previously unrecognized gene tldD, in the control of DNA gyrase by letD (ccdB) of sex factor F." ]
[ 1996 ]
1
[]
[]
0
0
null
[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]
[ 680, 10545, 13, 169 ]
4
[ "Escherichia coli (strain K12)" ]
[ 1 ]
1
true
Family
TldD
TldD
TldD
8
IPR025503
25,503
Protein of unknown function DUF4391
DUF4391
Family
1,391
false
false
This family of proteins is functionally uncharacterised.
[]
[]
[]
0
[ "PFAM" ]
[ "PF14335" ]
[ "DUF4391" ]
[ 1391 ]
1
[]
[]
[]
0
[]
0
[]
[]
[]
[]
0
[]
[]
0
0
null
[ "Bacteria", "Eukaryota", "Methanobacteriati", "Siphoviridae sp. ctqBH20", "metagenomes" ]
[ 1350, 2, 20, 1, 18 ]
5
[]
[]
0
true
Family
Protein of unknown function DUF4391
Protein of unknown function DUF4391
DUF4391
9
IPR025504
25,504
D-glutamate cyclase-like, C-terminal
GLUCM_C
Domain
2,253
false
false
This entry represents the C-terminal domain found in mitochondrial D-glutamate cyclase ( ), which converts D-glutamate to 5-oxo-D-proline [ ]. There are two completely conserved G residues that may be functionally important. This domain is also found in numerous uncharacterised proteins from bacteria.
[]
[]
[]
0
[ "PFAM" ]
[ "PF14336" ]
[ "GLUCM-like_C" ]
[ 2253 ]
1
[]
[]
[]
0
[ "4dwz", "4fc5", "5gkx", "5gl2", "5gl3", "5gl4" ]
6
[ "PUB00086027" ]
[ "28266638" ]
[ "D-Glutamate is metabolized in the heart mitochondria." ]
[ 2017 ]
1
[]
[]
0
0
null
[ "Archaea", "Bacteria", "Eukaryota", "metagenomes" ]
[ 71, 793, 1361, 28 ]
4
[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]
[ 4, 10, 4, 5 ]
4
true
Domain
D-glutamate cyclase-like, C-terminal
D-glutamate cyclase-like, C-terminal
GLUCM_C
2