LiteFold/InterPro · Datasets at Hugging Face

IPR051013

51,013

N-acyl homoserine lactonase-like

AiiA-like

Family

34,778

true

This family of proteins includes enzymes that exhibit hydrolytic activity on various lactone substrates, including N-acyl homoserine lactonase from Bacillus thuringiensis, which catalyses the hydrolysis of N-acyl homoserine lactones, which are signalling molecules involved in bacterial quorum sensing [ ]. Some family m...

[]

0

[ "PANTHER" ]

[ "PTHR42978" ]

[ "MBL_superfamily_lactonases" ]

[ 34778 ]

1

[ "EC" ]

[ "3.1.1" ]

[ "EC:3.1.1" ]

1

[ "1p9e", "2a7m", "2br6", "2btn", "2r2d", "3aj3", "3dha", "3dhb", "3dhc", "3esh", "4j5f", "4j5h", "4kep", "4keq", "4le6", "4o98", "4xuk", "4zo2", "4zo3", "5eh9", "5eht", "5hif", "6c2c", "6cgy", "6cgz", "6ch0", "6n9i", "6n9q", "6n9r", "7l5f", "7y7u", "8x78"...

43

[ "PUB00137430", "PUB00162893", "PUB00163190" ]

[ "15895999", "24699732", "26296598" ]

[ "The quorum-quenching lactonase from Bacillus thuringiensis is a metalloprotein.", "Structure of 4-pyridoxolactonase from Mesorhizobium loti.", "A γ-lactamase from cereal infecting Fusarium spp. catalyses the first step in the degradation of the benzoxazolinone class of phytoalexins." ]

[ 2005, 2014, 2015 ]

3

[]

[ "IPR054870", "IPR054889" ]

0

2

0

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 409, 28543, 5526, 300 ]

4

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)" ]

[ 1 ]

1

true

Family

N-acyl homoserine lactonase-like

AiiA-like

2

IPR051014

51,014

Cation Transport ATPase Type IB

Cation_Transport_ATPase_IB

Family

30,958

true

false

The cation transport ATPase (P-type) family, specifically the Type IB subfamily, is involved in the transport of heavy metals such as cadmium, zinc, and cobalt across cellular membranes. Members of this family couple the hydrolysis of ATP to the efflux of these metal ions, which is crucial for metal detoxification and ...

[]

0

[ "PANTHER" ]

[ "PTHR48085" ]

[ "Cation_Transport_ATPase_IB" ]

[ 30958 ]

1

[ "EC", "EC" ]

[ "7.2.2", "7.2.2.21" ]

[ "EC:7.2.2", "EC:7.2.2.21" ]

2

[ "2iye", "2kkh", "2yj3", "2yj4", "2yj5", "2yj6", "3skx", "3sky", "4umv", "4umw", "7qbz", "7qc0" ]

12

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 940, 27575, 2095, 348 ]

4

[ "Arabidopsis thaliana", "Escherichia coli (strain K12)", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 21, 1, 9, 76 ]

4

true

Family

Cation Transport ATPase Type IB

Cation_Transport_ATPase_IB

1

IPR051017

51,017

Aldolase class II Adducin subfamily

Aldolase-II_Adducin_sf

Family

25,870

true

false

The Aldolase class II, Adducin subfamily, consists of membrane-cytoskeleton-associated proteins that promote the assembly of the spectrin-actin network, which is crucial for maintaining cell shape and integrity. Members of this family are involved in various cellular processes including actin filament capping, cell mig...

[]

0

[ "PANTHER" ]

[ "PTHR10672" ]

[ "Aldolase-II_Adducin_sf" ]

[ 25870 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-CEL-264870", "R-CEL-5223345", "R-CEL-9013405", "R-CEL-9035034", "R-DME-264870", "R-DME-5223345", "R-DME-9013405", "R-DME-9035034", "R-HSA-264870", "R-HSA-381038", "R-HSA-5223345", "R-HSA-9013405", "R-HSA-9035034", "R-MMU-264870", "R-MMU-5223345", "R-MMU-9013405", "R-MMU-9035034", ...

[ "REACTOME:R-CEL-264870", "REACTOME:R-CEL-5223345", "REACTOME:R-CEL-9013405", "REACTOME:R-CEL-9035034", "REACTOME:R-DME-264870", "REACTOME:R-DME-5223345", "REACTOME:R-DME-9013405", "REACTOME:R-DME-9035034", "REACTOME:R-HSA-264870", "REACTOME:R-HSA-381038", "REACTOME:R-HSA-5223345", "REACTOME:R-...

22

[ "3ocr", "4xxf", "8iah", "8iai", "8il8", "8iqa", "8ix6", "9ryg" ]

8

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 12435, 13198, 237 ]

3

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 4, 71, 8, 24, 23, 1, 18, 2 ]

8

true

Family

Aldolase class II Adducin subfamily

Aldolase-II_Adducin_sf

8

IPR051019

51,019

VLCFA Elongation and Steroid Dehydrogenase

VLCFA-Steroid_DH

Family

11,011

true

false

The protein family includes enzymes that catalyze key reactions in lipid metabolism and steroid hormone biosynthesis. Members are involved in the elongation cycle of long-chain fatty acids, adding two carbons to produce very long-chain fatty acids (VLCFAs), which are precursors for membrane lipids and lipid mediators. ...

[]

0

[ "PANTHER" ]

[ "PTHR43899" ]

[ "VLCFA-Steroid_DH" ]

[ 11011 ]

1

[ "EC", "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "1.1.1", "1.1.1.62", "R-CEL-193048", "R-CEL-75876", "R-DRE-193048", "R-DRE-75876", "R-HSA-193048", "R-HSA-75876", "R-MMU-193048", "R-MMU-75876", "R-RNO-193048", "R-RNO-75876", "R-XTR-75876" ]

[ "EC:1.1.1", "EC:1.1.1.62", "REACTOME:R-CEL-193048", "REACTOME:R-CEL-75876", "REACTOME:R-DRE-193048", "REACTOME:R-DRE-75876", "REACTOME:R-HSA-193048", "REACTOME:R-HSA-75876", "REACTOME:R-MMU-193048", "REACTOME:R-MMU-75876", "REACTOME:R-RNO-193048", "REACTOME:R-RNO-75876", "REACTOME:R-XTR-7587...

13

[ "5fyd", "5gt9" ]

2

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Methanobacteriati", "unclassified sequences" ]

[ 2157, 8775, 3, 76 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 6, 1, 18, 2, 12, 7, 32, 9, 11 ]

9

true

Family

VLCFA Elongation and Steroid Dehydrogenase

VLCFA-Steroid_DH

4

IPR051020

51,020

Aldehyde dehydrogenase-related metabolic enzymes

ALDH-related_metabolic_enz

Family

11,352

true

false

This family of proteins includes various aldehyde dehydrogenases with diverse functions. Members are involved in metabolic pathways such as the degradation of D-sulfoquinovose, generating sulfolactate, and the utilization of taurine as a nitrogen source. Some enzymes in this family are responsible for the NAD(P)-depend...

[]

0

[ "PANTHER" ]

[ "PTHR42991" ]

[ "ALDH-related_metabolic_enz" ]

[ 11352 ]

1

[ "EC" ]

[ "1.2.1" ]

[ "EC:1.2.1" ]

1

[ "1euh", "1ky8", "1qi1", "1qi6", "1uxn", "1uxp", "1uxq", "1uxr", "1uxt", "1uxu", "1uxv", "2esd", "2euh", "2id2", "2qe0", "3pqa", "3prl", "3rhd", "3rhh", "4i3t", "4i3u", "4i3v", "4i3w", "4i3x", "5j6b", "5jry", "5kf0", "5mz5", "5mz8", "5n5s", "7pkc", "7pkj"...

40

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 452, 9385, 1312, 203 ]

4

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 7, 4, 7 ]

3

true

Family

Aldehyde dehydrogenase-related metabolic enzymes

ALDH-related_metabolic_enz

7

IPR051021

51,021

Mitochondrial serine/threonine phosphatase

Mito_Ser/Thr_phosphatase

Family

10,494

true

false

This family of proteins exhibits serine/threonine phosphatase activity, with members involved in the dephosphorylation and activation of specific kinases such as Pk92B and MAP3K5. Despite being classified within the phosphoglycerate mutase family, these proteins do not display phosphoglycerate mutase activity. They are...

[]

0

[ "PANTHER" ]

[ "PTHR20935" ]

[ "Mito_Ser/Thr_phosphatase" ]

[ 10494 ]

1

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "3.1.3.16", "R-CEL-8934903", "R-CEL-9861718", "R-DME-8934903", "R-DME-9861718", "R-DRE-8934903", "R-DRE-9861718", "R-HSA-8934903", "R-HSA-9861718", "R-MMU-8934903", "R-MMU-9861718", "R-RNO-8934903", "R-RNO-9861718", "R-XTR-8934903" ]

[ "EC:3.1.3.16", "REACTOME:R-CEL-8934903", "REACTOME:R-CEL-9861718", "REACTOME:R-DME-8934903", "REACTOME:R-DME-9861718", "REACTOME:R-DRE-8934903", "REACTOME:R-DRE-9861718", "REACTOME:R-HSA-8934903", "REACTOME:R-HSA-9861718", "REACTOME:R-MMU-8934903", "REACTOME:R-MMU-9861718", "REACTOME:R-RNO-893...

14

[ "3eoz", "3f2i", "3mxo", "3o0t", "5muf", "6cni", "6cnl" ]

7

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "metagenomes" ]

[ 64, 7647, 2711, 72 ]

4

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 2, 4, 3, 4, 3 ]

6

true

Family

Mitochondrial serine/threonine phosphatase

Mito_Ser/Thr_phosphatase

4

IPR051025

51,025

Rho GTPase-activating

RhoGAP

Family

12,274

true

false

The Rho GTPase-activating protein (RhoGAP) family is involved in the regulation of the Rho-type GTPases, which are critical for actin cytoskeleton dynamics, cell morphology, polarity, and motility. Family members act as GTPase activators by converting active GTP-bound Rho GTPases to their inactive GDP-bound state. Some...

[]

0

[ "PANTHER" ]

[ "PTHR15228" ]

[ "RhoGAP" ]

[ 12274 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-8980692", "R-BTA-9013148", "R-BTA-9013149", "R-DRE-8980692", "R-DRE-9013148", "R-DRE-9013149", "R-HSA-6798695", "R-HSA-8980692", "R-HSA-9013148", "R-HSA-9013149", "R-MMU-6798695", "R-MMU-8980692", "R-MMU-9013148", "R-MMU-9013149", "R-RNO-8980692", "R-RNO-9013148", "R-RNO-90131...

[ "REACTOME:R-BTA-8980692", "REACTOME:R-BTA-9013148", "REACTOME:R-BTA-9013149", "REACTOME:R-DRE-8980692", "REACTOME:R-DRE-9013148", "REACTOME:R-DRE-9013149", "REACTOME:R-HSA-6798695", "REACTOME:R-HSA-8980692", "REACTOME:R-HSA-9013148", "REACTOME:R-HSA-9013149", "REACTOME:R-MMU-6798695", "REACTOM...

23

[ "3qwe" ]

1

[]

0

[]

0

null

[ "Eukaryota" ]

[ 12274 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 5, 47, 42, 16, 3, 27, 2, 1 ]

8

true

Family

Rho GTPase-activating

RhoGAP

9

IPR051026

51,026

Phosphatidylinositol/phosphatidylcholine transfer

PI/PC_transfer

Family

13,472

true

false

This family of proteins is involved in the intracellular transport of secretory proteins, particularly from the Golgi complex. Members of this family have the ability to catalyze the transfer of phosphatidylinositol and phosphatidylcholine between different membranes in vitro. Some proteins within this family also play...

[]

0

[ "PANTHER" ]

[ "PTHR45657" ]

[ "PI/PC_transfer" ]

[ 13472 ]

1

[]

0

[ "1aua", "3b74", "3b7n", "3b7q", "3b7z", "3q8g", "6f0e", "6sld", "7y10", "7y11", "7zg9", "7zga", "7zgb", "7zgc", "7zgd", "9efn", "9efp", "9yv3" ]

18

[]

0

[]

0

null

[ "Chryseobacterium contaminans", "Eukaryota" ]

[ 1, 13471 ]

2

[ "Arabidopsis thaliana", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)", "Zea mays" ]

[ 87, 2, 41, 2, 1, 236 ]

6

true

Family

Phosphatidylinositol/phosphatidylcholine transfer

PI/PC_transfer

6

IPR051028

51,028

Mitochondrial Solute Carrier

Mito_Solute_Carrier

Family

10,092

true

false

This family of proteins includes mitochondrial carriers that facilitate the transport of solutes, metabolites, nucleotides, and cofactors across the mitochondrial inner membrane. They play a crucial role in various metabolic processes, including the malate-aspartate shuttle, which is essential for transferring reducing...

[]

0

[ "PANTHER" ]

[ "PTHR45678" ]

[ "Mito_Solute_Carrier" ]

[ 10092 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-428643", "R-BTA-9856872", "R-CEL-8963693", "R-CEL-9856872", "R-DDI-428643", "R-DDI-8963693", "R-DDI-9856872", "R-DME-8963693", "R-DME-9856872", "R-HSA-1268020", "R-HSA-428643", "R-HSA-8963693", "R-HSA-9856872", "R-MMU-428643", "R-MMU-8963693", "R-MMU-9856872", "R-RNO-428643", ...

[ "REACTOME:R-BTA-428643", "REACTOME:R-BTA-9856872", "REACTOME:R-CEL-8963693", "REACTOME:R-CEL-9856872", "REACTOME:R-DDI-428643", "REACTOME:R-DDI-8963693", "REACTOME:R-DDI-9856872", "REACTOME:R-DME-8963693", "REACTOME:R-DME-9856872", "REACTOME:R-HSA-1268020", "REACTOME:R-HSA-428643", "REACTOME:R...

22

[]

0

[]

0

[]

0

null

[ "Candidatus Chromulinivorax destructor", "Eukaryota", "Pithovirus LCPAC302", "viral metagenome" ]

[ 1, 10088, 1, 2 ]

4

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)" ]

[ 3, 17, 6, 25, 17, 1, 17, 1 ]

8

true

Family

Mitochondrial Solute Carrier

Mito_Solute_Carrier

5

IPR051030

51,030

Vitamin B12-binding component of ABC transporter

Vitamin_B12-ABC_binding

Family

3,982

true

false

This family of proteins is involved in the transport of vitamin B12 across cellular membranes. They are components of the ATP-binding cassette (ABC) transporter complex BtuCDF, which is responsible for the import of vitamin B12. Members of this family specifically bind vitamin B12 and are responsible for delivering it ...

[]

0

[ "PANTHER" ]

[ "PTHR42860" ]

[ "Vitamin_B12-ABC_binding" ]

[ 3982 ]

1

[]

0

[ "5ysc" ]

1

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 503, 2964, 418, 97 ]

4

[]

0

true

Family

Vitamin B12-binding component of ABC transporter

Vitamin_B12-ABC_binding

7

IPR051033

51,033

SH3 domain-binding glutamic acid-rich protein

SH3BGR

Family

6,391

true

false

This family of proteins appears to be involved in various cellular processes, including acting as adapter proteins that may bridge other proteins or proteins with mRNAs, potentially influencing the expression of specific mRNAs. Some members are suggested to function as ubiquitin ligase-substrate adapters, which could t...

[]

0

[ "PANTHER" ]

[ "PTHR12232" ]

[ "SH3BGR" ]

[ 6391 ]

1

[]

0

[ "1j0f", "1sj6", "1t1v", "1u6t", "1wry", "2ct6", "8iah", "8iai" ]

8

[]

0

[]

0

null

[ "Eukaryota" ]

[ 6391 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus" ]

[ 2, 38, 4, 14, 15, 1, 19 ]

7

true

Family

SH3 domain-binding glutamic acid-rich protein

SH3BGR

5

IPR051034

51,034

Mitochondrial Enoyl-ACP Reductase

Mito_Enoyl-ACP_Reductase

Family

6,884

true

false

The mitochondrial enoyl-[acyl-carrier-protein] reductase family is involved in the NADPH-dependent reduction of trans-2-enoyl thioesters as part of mitochondrial fatty acid synthesis type II. Members of this family utilize acyl carrier protein (ACP) as an acyl group carrier, although they can also accept CoA thioesters...

[]

0

[ "PANTHER" ]

[ "PTHR43981" ]

[ "Mito_Enoyl-ACP_Reductase" ]

[ 6884 ]

1

[ "EC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "1.3.1.104", "PWY-8280", "R-CEL-77346", "R-DDI-77346", "R-DME-77346", "R-DRE-77346", "R-HSA-77346", "R-MMU-77346", "R-RNO-77346", "R-SCE-77346", "R-SPO-77346", "R-XTR-77346" ]

[ "EC:1.3.1.104", "METACYC:PWY-8280", "REACTOME:R-CEL-77346", "REACTOME:R-DDI-77346", "REACTOME:R-DME-77346", "REACTOME:R-DRE-77346", "REACTOME:R-HSA-77346", "REACTOME:R-MMU-77346", "REACTOME:R-RNO-77346", "REACTOME:R-SCE-77346", "REACTOME:R-SPO-77346", "REACTOME:R-XTR-77346" ]

12

[ "1gu7", "1guf", "1gyr", "1h0k", "1n9g", "1zsy", "2vcy", "4w99", "4was", "5lb9", "5lbx", "7ayb", "7ayc", "8iuf", "8j9h", "8j9i", "8j9j" ]

17

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "ecological metagenomes" ]

[ 1444, 5430, 10 ]

3

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 4, 3, 6, 2, 3, 2, 1, 10, 4, 1, 1, 6 ]

12

true

Family

Mitochondrial Enoyl-ACP Reductase

Mito_Enoyl-ACP_Reductase

2

IPR051035

51,035

Mitochondrial inheritance protein 9

Mito_inheritance_9

Family

5,559

true

false

This family of proteins is involved in the inheritance and distribution of mitochondria, which are essential organelles responsible for energy production in eukaryotic cells. Members of this family may play a role in ensuring proper mitochondrial segregation during cell division, thereby influencing mitochondrial bioge...

[]

0

[ "PANTHER" ]

[ "PTHR36091" ]

[ "Mito_inheritance_9" ]

[ 5559 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Eukaryota" ]

[ 5559 ]

1

[ "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)" ]

[ 1 ]

1

true

Family

Mitochondrial inheritance protein 9

Mito_inheritance_9

6

IPR051036

51,036

Sialic acid-binding Ig-like lectin

SIGLEC

Family

5,867

true

false

The SIGLEC family proteins are sialic acid-binding Ig-like lectins involved in cell-cell adhesion, immune regulation, and maintenance of immune cells in a resting state. They recognize and bind to sialic acid-bearing glycans, mediating interactions with a preference for alpha-2,3- or alpha-2,6-linked sialic acid. SIGLE...

[]

0

[ "PANTHER" ]

[ "PTHR12035" ]

[ "SIGLEC" ]

[ 5867 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-193634", "R-HSA-198933", "R-HSA-210991", "R-HSA-2172127", "R-HSA-6798695", "R-HSA-9619665", "R-MMU-193634", "R-MMU-198933", "R-MMU-210991", "R-MMU-2172127", "R-MMU-6798695", "R-RNO-193634", "R-RNO-210991" ]

[ "REACTOME:R-HSA-193634", "REACTOME:R-HSA-198933", "REACTOME:R-HSA-210991", "REACTOME:R-HSA-2172127", "REACTOME:R-HSA-6798695", "REACTOME:R-HSA-9619665", "REACTOME:R-MMU-193634", "REACTOME:R-MMU-198933", "REACTOME:R-MMU-210991", "REACTOME:R-MMU-2172127", "REACTOME:R-MMU-6798695", "REACTOME:R-RN...

13

[ "1nko", "1o7s", "1o7v", "2df3", "2g5r", "2hrl", "2n7a", "2n7b", "2zg1", "2zg2", "2zg3", "5ihb", "5j06", "5j0b", "5lf5", "5lfr", "5lfu", "5lfv", "6d48", "6d49", "6d4a", "7aw6", "7qu6", "7quh", "7qui" ]

25

[]

0

[]

0

null

[ "Metazoa" ]

[ 5867 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 52, 39, 30, 25 ]

4

true

Family

Sialic acid-binding Ig-like lectin

SIGLEC

1

IPR051037

51,037

RNA Polymerase II Transcription Factor IWS1

RNAPII_TF_IWS1

Family

4,548

true

false

The IWS1 family comprises transcription factors that play crucial roles in RNA polymerase II (RNAPII) transcription regulation. Members of the IWS1 family are involved in various stages of the transcription process, including post-recruitment and recruitment of SPT15/TBP. They are key in defining the composition of the...

[]

0

[ "PANTHER" ]

[ "PTHR46010" ]

[ "RNAPII_TF_IWS1" ]

[ 4548 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-CEL-112382", "R-CEL-674695", "R-CEL-75955", "R-HSA-112382", "R-HSA-674695", "R-HSA-75955", "R-MMU-112382", "R-MMU-674695", "R-MMU-75955", "R-RNO-112382", "R-RNO-674695", "R-RNO-75955", "R-XTR-112382", "R-XTR-674695", "R-XTR-75955" ]

[ "REACTOME:R-CEL-112382", "REACTOME:R-CEL-674695", "REACTOME:R-CEL-75955", "REACTOME:R-HSA-112382", "REACTOME:R-HSA-674695", "REACTOME:R-HSA-75955", "REACTOME:R-MMU-112382", "REACTOME:R-MMU-674695", "REACTOME:R-MMU-75955", "REACTOME:R-RNO-112382", "REACTOME:R-RNO-674695", "REACTOME:R-RNO-75955"...

15

[ "2xpl", "2xpn", "2xpo", "2xpp", "3nfq", "3o8z", "3oak", "6emr", "6zv1", "7xn7", "7xse", "7xsx", "7xsz", "7xt7", "7xtd", "7xti", "9egx", "9egy", "9egz", "9eh0", "9eh1", "9eh2", "9rtt" ]

23

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Haloquadratum walsbyi J07HQW2" ]

[ 9, 4538, 1 ]

3

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strai...

[ 1, 5, 5, 5, 4, 1, 8, 1, 1 ]

9

true

Family

RNA Polymerase II Transcription Factor IWS1

RNAPII_TF_IWS1

7

IPR051038

51,038

RMT2/GAMT Methyltransferase

RMT2/GAMT_Mtase

Family

3,869

true

false

The RMT2 methyltransferase family comprises enzymes that utilize S-adenosyl-L-methionine (SAM) to methylate arginine residues in target proteins, forming N5-methylarginine. This modification plays a critical role in the regulation of protein function and RNA processing. Members of this family are also involved in the c...

[]

0

[ "PANTHER" ]

[ "PTHR32379" ]

[ "RMT2/GAMT_Mtase" ]

[ 3869 ]

1

[ "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC"...

[ "2.1.1.-", "PWY-1061", "PWY-2083", "PWY-3542", "PWY-4021", "PWY-4161", "PWY-4202", "PWY-5059", "PWY-5105", "PWY-5301", "PWY-5305", "PWY-5479", "PWY-5665", "PWY-5729", "PWY-5748", "PWY-5765", "PWY-5773", "PWY-5846", "PWY-5883", "PWY-5975", "PWY-5987", "PWY-601", "PWY-6045"...

[ "EC:2.1.1.-", "METACYC:PWY-1061", "METACYC:PWY-2083", "METACYC:PWY-3542", "METACYC:PWY-4021", "METACYC:PWY-4161", "METACYC:PWY-4202", "METACYC:PWY-5059", "METACYC:PWY-5105", "METACYC:PWY-5301", "METACYC:PWY-5305", "METACYC:PWY-5479", "METACYC:PWY-5665", "METACYC:PWY-5729", "METACYC:PWY-5...

155

[ "1khh", "1p1b", "1p1c", "1xcj", "1xcl", "3orh" ]

6

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Viruses", "metagenomes" ]

[ 160, 3702, 3, 4 ]

4

[ "Arabidopsis thaliana", "Danio rerio", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (st...

[ 6, 2, 5, 1, 1, 2, 4, 1, 1, 6 ]

10

true

Family

RMT2/GAMT Methyltransferase

RMT2/GAMT_Mtase

9

IPR051040

51,040

Cytochrome c oxidase-assembly factor COX23

COX23

Family

2,522

true

false

The COX23 family consists of mitochondrial proteins that are essential for the assembly of cytochrome c oxidase, a key component of the mitochondrial respiratory chain responsible for the final step of the electron transport process. Members of the COX23 family play a crucial role in the proper functioning of the respi...

[]

0

[ "PANTHER" ]

[ "PTHR46811" ]

[ "COX23" ]

[ 2522 ]

1

[ "REACTOME" ]

[ "R-HSA-1268020" ]

[ "REACTOME:R-HSA-1268020" ]

1

[ "2lqt" ]

1

[]

0

[]

0

null

[ "Eukaryota" ]

[ 2522 ]

1

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)" ]

[ 1, 1, 6, 6, 1, 4, 1 ]

7

true

Family

Cytochrome c oxidase-assembly factor COX23

COX23

7

IPR051041

51,041

FMRFamide-related neuropeptide

FMRFamide-related_np

Family

1,081

true

false

This family of proteins includes neuropeptides that modulate various physiological processes. Members are involved in the modulation of muscle contraction in both somatic and visceral muscles, including the heart. They act as excitatory neurotransmitters at neuromuscular junctions and have roles in the regulation of ca...

[]

0

[ "PANTHER" ]

[ "PTHR20986" ]

[ "FMRFamide-related_np" ]

[ 1081 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Opisthokonta" ]

[ 1081 ]

1

[ "Caenorhabditis elegans", "Drosophila melanogaster" ]

[ 12, 1 ]

2

true

Family

FMRFamide-related neuropeptide

FMRFamide-related_np

3

IPR051042

51,042

Mammalian Reproductive Hormone Insulin-like

Repro_Hormone_Insulin-like

Family

434

true

false

The protein family in question is involved in various reproductive and developmental processes in mammals. Members of the family function as hormones, such as relaxin, which works with estrogen to dilate the birth canal during childbirth, and may also play a role in the remodeling of connective tissues during pregnancy...

[]

0

[ "PANTHER" ]

[ "PTHR12004" ]

[ "Repro_Hormone_Insulin-like" ]

[ 434 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-418555", "R-HSA-444821", "R-MMU-418555", "R-MMU-444821", "R-RNO-444821" ]

[ "REACTOME:R-HSA-418555", "REACTOME:R-HSA-444821", "REACTOME:R-MMU-418555", "REACTOME:R-MMU-444821", "REACTOME:R-RNO-444821" ]

5

[]

0

[]

0

[]

0

null

[ "Gnathostomata" ]

[ 434 ]

1

[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 5, 7, 5 ]

3

true

Family

Mammalian Reproductive Hormone Insulin-like

Repro_Hormone_Insulin-like

4

IPR051043

51,043

Sulfatase Modifying Factor and Kinase

Sulfatase_Mod_Factor_Kinase

Family

44,868

true

false

The protein family is involved in various biological processes, including the post-translational modification of sulfatases and the biosynthesis of ergothioneine, an antioxidant that protects bacteria from oxidative stress. Some family members are inactive enzymes that inhibit sulfatase activation, while others are act...

[]

0

[ "PANTHER" ]

[ "PTHR23150" ]

[ "Sulfatase_Mod_Factor_Kinase" ]

[ 44868 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-1663150", "R-BTA-9840310", "R-HSA-1663150", "R-HSA-9840310", "R-MMU-1663150", "R-MMU-9840310" ]

[ "REACTOME:R-BTA-1663150", "REACTOME:R-BTA-9840310", "REACTOME:R-HSA-1663150", "REACTOME:R-HSA-9840310", "REACTOME:R-MMU-1663150", "REACTOME:R-MMU-9840310" ]

6

[ "1y1e", "1y1f", "1y1g", "1y1h", "1y1i", "1y1j", "1y4j", "1z70", "2aft", "2afy", "2aii", "2aij", "2aik", "2hi8", "2hib", "2q17", "2y3c", "4x8b", "4x8d", "4x8e", "5aoh", "5hha", "5nxl", "5nyy", "5ssx", "5ssy", "5ssz", "6muj", "6o6l", "6o6m", "6qki", "6qkj"...

64

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 260, 39449, 4337, 13, 809 ]

5

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 4, 3, 26, 9, 7 ]

5

true

Family

Sulfatase Modifying Factor and Kinase

Sulfatase_Mod_Factor_Kinase

4

IPR051044

51,044

Monoacylglycerol and Diacylglycerol Lipase

MAG_DAG_Lipase

Family

46,958

true

false

The protein family is involved in the hydrolysis of various lipid substrates, including monoacylglycerides and diacylglycerides, to free fatty acids and glycerol. Members of the family contribute to diverse biological processes such as endocannabinoid signaling, nociperception, pain perception, cancer cell migration, i...

[]

0

[ "PANTHER" ]

[ "PTHR11614" ]

[ "MAG_DAG_Lipase" ]

[ 46958 ]

1

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "3.1.1", "R-DDI-1482883", "R-DDI-426048", "R-HSA-1482883", "R-HSA-163560", "R-HSA-426048", "R-HSA-9841922", "R-MMU-1482883", "R-MMU-426048", "R-RNO-1482883", "R-RNO-426048", "R-SCE-1482883", "R-SCE-426048", "R-SPO-1482883", "R-SPO-426048" ]

[ "EC:3.1.1", "REACTOME:R-DDI-1482883", "REACTOME:R-DDI-426048", "REACTOME:R-HSA-1482883", "REACTOME:R-HSA-163560", "REACTOME:R-HSA-426048", "REACTOME:R-HSA-9841922", "REACTOME:R-MMU-1482883", "REACTOME:R-MMU-426048", "REACTOME:R-RNO-1482883", "REACTOME:R-RNO-426048", "REACTOME:R-SCE-1482883", ...

15

[ "1r1d", "1tqh", "3hju", "3jw8", "3jwe", "3pe6", "3rli", "3rm3", "4diu", "4fbl", "4fbm", "4ke7", "4ke8", "4ke9", "4lhe", "4uuq", "4zwn", "4zxf", "5o7g", "5olu", "5xks", "5zun", "6ax1", "6bq0", "6eic", "6khk", "6khl", "6khm", "6nkg", "6qe2", "7e04", "7e0n"...

63

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Bamfordvirae", "Eukaryota", "unclassified sequences" ]

[ 139, 31664, 88, 14704, 363 ]

5

[ "Arabidopsis thaliana", "Danio rerio", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)...

[ 81, 3, 2, 7, 5, 1, 45, 5, 1, 1, 92 ]

11

true

Family

Monoacylglycerol and Diacylglycerol Lipase

MAG_DAG_Lipase

2

IPR051045

51,045

TonB-dependent transporter energy transducer

TonB-dependent_transducer

Family

36,622

true

false

This family of proteins interacts with outer membrane receptor proteins to facilitate the high-affinity binding and energy-dependent uptake of specific substrates into the periplasmic space. Members of this family are involved in the transduction of energy from the cytoplasmic membrane to outer membrane processes that ...

[]

0

[ "PANTHER" ]

[ "PTHR33446" ]

[ "TonB-dependent_transducer" ]

[ 36622 ]

1

[ "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-9638334", "R-HSA-9638482", "R-HSA-9927020" ]

[ "REACTOME:R-HSA-9638334", "REACTOME:R-HSA-9638482", "REACTOME:R-HSA-9927020" ]

3

[ "1ihr", "1qxx", "1u07", "1xx3", "2grx", "2gsk", "2k9k", "2m2k", "5lw8", "6fip", "6i97", "6sly", "8rd6", "9ddo", "9ddp", "9ddq" ]

16

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Viruses", "candidate division MSBL1 archaeon SCGC-AAA382M17", "unclassified sequences" ]

[ 36133, 43, 3, 2, 441 ]

5

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

TonB-dependent transporter energy transducer

TonB-dependent_transducer

8

IPR051046

51,046

MurCDEF Family: Cell Wall and Coenzyme F430 Synthesis

MurCDEF_CellWall_CoF430Synth

Family

30,291

true

false

The MurCDEF family is involved in essential biological processes, including cell wall formation and methanogenesis. Members of the MurF subfamily, such as UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligases, catalyze the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, a precursor of murein, wh...

[]

0

[ "PANTHER" ]

[ "PTHR43024" ]

[ "MurCDEF_CellWall_CoF430Synth" ]

[ 30291 ]

1

[ "EC", "METACYC", "METACYC", "METACYC" ]

[ "6.3.2.10", "PWY-6386", "PWY-6387", "PWY-7953" ]

[ "EC:6.3.2.10", "METACYC:PWY-6386", "METACYC:PWY-6387", "METACYC:PWY-7953" ]

4

[ "1gg4", "2am1", "2am2", "3zl8", "3zm5", "3zm6", "4cvk", "4cvl", "4cvm", "4qdi", "4qf5", "4ziy" ]

12

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Methanobacteriati", "unclassified sequences" ]

[ 29054, 316, 161, 760 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

MurCDEF Family: Cell Wall and Coenzyme F430 Synthesis

MurCDEF_CellWall_CoF430Synth

8

IPR051047

51,047

Acyl-CoA Carboxylase Beta Subunit

AccD/PCCB

Family

27,544

true

false

The AccD/PCCB family comprises enzymes involved in fatty acid and amino acid metabolism. Members of this family function as carboxyltransferases, which are part of larger enzyme complexes that catalyze the carboxylation of various CoA ester substrates. These enzymes are biotin-dependent and play a role in the catabolis...

[]

0

[ "PANTHER" ]

[ "PTHR43842" ]

[ "AccD/PCCB" ]

[ 27544 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-196780", "R-HSA-3371599", "R-HSA-71032", "R-HSA-9837999", "R-MMU-196780", "R-MMU-71032", "R-MMU-9837999", "R-RNO-196780", "R-RNO-71032", "R-RNO-9837999", "R-SSC-196780", "R-SSC-71032", "R-SSC-9837999" ]

[ "REACTOME:R-HSA-196780", "REACTOME:R-HSA-3371599", "REACTOME:R-HSA-71032", "REACTOME:R-HSA-9837999", "REACTOME:R-MMU-196780", "REACTOME:R-MMU-71032", "REACTOME:R-MMU-9837999", "REACTOME:R-RNO-196780", "REACTOME:R-RNO-71032", "REACTOME:R-RNO-9837999", "REACTOME:R-SSC-196780", "REACTOME:R-SSC-71...

13

[ "1on3", "1on9", "1vrg", "1x0u", "1xnv", "1xnw", "1xny", "1xo6", "2a7s", "2bzr", "3iav", "3ib9", "3ibb", "3mfm", "3n6r", "4fb8", "4g2r", "4l6w", "5fif", "5inf", "5ing", "5ini", "6p7u", "6pk2", "6prw", "6tzv", "6ybp", "6ybq", "7w5u", "7ybu", "8pn7", "8pn8"...

39

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 1912, 21100, 3736, 796 ]

4

[ "Caenorhabditis elegans", "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 2, 21, 9, 9 ]

5

true

Family

Acyl-CoA Carboxylase Beta Subunit

AccD/PCCB

7

IPR051048

51,048

Peptidase S8/S53 subtilisin kexin sedolisin

Peptidase_S8/S53_subtilisin

Family

16,595

true

false

The peptidase S8 family encompasses a group of serine proteases with diverse functions, including broad substrate specificity, involvement in virulence as C5a peptidases that cleave human serum chemotaxin C5a, and roles in various cellular processes such as intracellular proteolysis, fruiting body formation, and swarmi...

[]

0

[ "PANTHER" ]

[ "PTHR43399" ]

[ "Peptidase_S8/S53_subtilisin" ]

[ 16595 ]

1

[ "EC", "REACTOME" ]

[ "3.4.21", "R-PFA-2173796" ]

[ "EC:3.4.21", "REACTOME:R-PFA-2173796" ]

2

[ "1wmd", "1wme", "1wmf", "1xf1", "2e1p", "2wv7", "2wwt", "2x8j", "2xrm", "2z2x", "2z2y", "2z2z", "2z30", "2z56", "2z57", "2z58", "2zrq", "3a3n", "3a3o", "3a3p", "3eif", "3ti7", "3ti9", "3vhq", "3vv2", "3vv3", "3wiu", "3wiv", "4jp8", "4lvn", "4lvo", "4tr2"...

47

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 263, 12032, 4132, 4, 164 ]

5

[]

0

true

Family

Peptidase S8/S53 subtilisin kexin sedolisin

Peptidase_S8/S53_subtilisin

8

IPR051049

51,049

Dienelactone hydrolase-like enzyme

Dienelactone_hydrolase-like

Family

26,221

true

false

This family of proteins is involved in the ring cleavage of cyclic ester dienelactone to produce maleylacetate, a step in the degradation of certain compounds. Some members of this family have been identified as carboxymethylenebutenolidases, which are enzymes that catalyze the hydrolysis of dienelactone, a compound th...

[]

0

[ "PANTHER" ]

[ "PTHR46623" ]

[ "Dienelactone_hydrolase-like" ]

[ 26221 ]

1

[ "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC" ]

[ "3.1.1.45", "PWY-6084", "PWY-6087", "PWY-6089", "PWY-6093", "PWY-6094", "PWY-6193" ]

[ "EC:3.1.1.45", "METACYC:PWY-6084", "METACYC:PWY-6087", "METACYC:PWY-6089", "METACYC:PWY-6093", "METACYC:PWY-6094", "METACYC:PWY-6193" ]

7

[ "1din", "1ggv", "1zi6", "1zi8", "1zi9", "1zic", "1zix", "1ziy", "1zj4", "1zj5", "3f67", "4p92", "4p93", "4u2b", "4u2c", "4u2d", "4u2e", "4u2f", "4u2g", "4zv9", "8g2z", "8g3d", "8sf7", "9bld", "9ble" ]

25

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 162, 24382, 1304, 373 ]

4

[ "Arabidopsis thaliana", "Escherichia coli (strain K12)", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 9, 2, 4, 4 ]

4

true

Family

Dienelactone hydrolase-like enzyme

Dienelactone_hydrolase-like

8

IPR051050

51,050

Lipid II flippase MurJ/MviN

Lipid_II_flippase_MurJ/MviN

Family

23,224

true

false

This family of proteins is involved in bacterial cell wall synthesis, specifically in the process of peptidoglycan biosynthesis. Members of this family function as transporters that facilitate the movement of lipid-linked peptidoglycan precursors across the cytoplasmic membrane from the inner to the outer leaflet. This...

[]

0

[ "PANTHER" ]

[ "PTHR47019" ]

[ "Lipid_II_flippase_MurJ/MviN" ]

[ 23224 ]

1

[]

0

[ "5t77", "6cc4", "6nc6", "6nc7", "6nc8", "6nc9", "7wag", "7waw", "7wax", "9ukv" ]

10

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 3, 22593, 30, 598 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Lipid II flippase MurJ/MviN

Lipid_II_flippase_MurJ/MviN

3

IPR051051

51,051

E3 ubiquitin-protein ligase TRIM/RNF

E3_ubiq-ligase_TRIM/RNF

Family

33,663

true

This family of proteins includes E3 ubiquitin-protein ligases with a role in innate immune defense, particularly against viral infections [ , , , ]. They mediate ubiquitination of key signalling molecules such as RIG-I and IFIH1/MDA5, which are crucial for the production of interferons in response to viral RNA [ , ]. S...

[]

0

[ "PANTHER" ]

[ "PTHR25465" ]

[ "E3_ubiq-ligase_TRIM/RNF" ]

[ 33663 ]

1

[ "EC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "2.3.2.27", "PWY-7511", "R-HSA-1169408", "R-HSA-168928", "R-HSA-5656169", "R-HSA-5689896", "R-HSA-877300", "R-HSA-918233", "R-HSA-933541", "R-HSA-933542", "R-HSA-933543", "R-HSA-936440", "R-HSA-9692916", "R-HSA-9705671", "R-HSA-9833109", "R-HSA-9833110", "R-HSA-9833482", "R-HSA-990...

[ "EC:2.3.2.27", "METACYC:PWY-7511", "REACTOME:R-HSA-1169408", "REACTOME:R-HSA-168928", "REACTOME:R-HSA-5656169", "REACTOME:R-HSA-5689896", "REACTOME:R-HSA-877300", "REACTOME:R-HSA-918233", "REACTOME:R-HSA-933541", "REACTOME:R-HSA-933542", "REACTOME:R-HSA-933543", "REACTOME:R-HSA-936440", "REA...

22

[ "2csv", "2ecj", "4b8e", "4cfg", "5eya", "5fer", "6flm", "6fln", "6jbm", "6sjh", "7jl0", "7jl1", "7jl2", "7jl3", "7jl4", "7qs3", "8g7t", "8g7u", "8g7v", "9i0t", "9iun" ]

21

[ "PUB00100805", "PUB00143666", "PUB00149599", "PUB00151462", "PUB00151464", "PUB00155144", "PUB00155145", "PUB00155146", "PUB00155147" ]

[ "31006531", "29038422", "30143514", "31160576", "34512673", "27693506", "28469175", "33849980", "36045682" ]

[ "Ubiquitin-Dependent and -Independent Roles of E3 Ligase RIPLET in Innate Immunity.", "TRIM29 promotes DNA virus infections by inhibiting innate immune response.", "TRIM16 controls assembly and degradation of protein aggregates by modulating the p62-NRF2 axis and autophagy.", "Knockdown of TRIM65 inhibits aut...

[ 2019, 2017, 2018, 2019, 2021, 2016, 2017, 2021, 2022 ]

9

[]

0

null

[ "Eukaryota", "Nocardioides malaquae", "Pacific salmon nidovirus", "bird metagenome" ]

[ 33660, 1, 1, 1 ]

4

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)" ]

[ 342, 37, 31, 36, 1 ]

5

true

Family

E3 ubiquitin-protein ligase TRIM/RNF

E3_ubiq-ligase_TRIM/RNF

8

IPR051052

51,052

Diverse substrate methyltransferase

Diverse_substrate_MTase

Family

24,038

true

false

This family of proteins includes enzymes with methyltransferase activity, which transfer methyl groups from S-adenosylmethionine to various substrates. Members of this family are involved in diverse biological processes, including the biosynthesis of secondary metabolites such as pigments, mycotoxins, and antibiotics, ...

[]

0

[ "PANTHER" ]

[ "PTHR44942" ]

[ "Diverse_substrate_MTase" ]

[ 24038 ]

1

[ "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC"...

[ "2.1.1.-", "PWY-1061", "PWY-2083", "PWY-3542", "PWY-4021", "PWY-4161", "PWY-4202", "PWY-5059", "PWY-5105", "PWY-5301", "PWY-5305", "PWY-5479", "PWY-5665", "PWY-5729", "PWY-5748", "PWY-5765", "PWY-5773", "PWY-5846", "PWY-5883", "PWY-5975", "PWY-5987", "PWY-601", "PWY-6045"...

[ "EC:2.1.1.-", "METACYC:PWY-1061", "METACYC:PWY-2083", "METACYC:PWY-3542", "METACYC:PWY-4021", "METACYC:PWY-4161", "METACYC:PWY-4202", "METACYC:PWY-5059", "METACYC:PWY-5105", "METACYC:PWY-5301", "METACYC:PWY-5305", "METACYC:PWY-5479", "METACYC:PWY-5665", "METACYC:PWY-5729", "METACYC:PWY-5...

146

[ "1vl5", "1xxl", "2glu", "3e7p", "3ege", "3g5t", "3kkz", "3t7r", "3t7s", "3t7t", "4hg2" ]

11

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Megaviridae environmental sample", "unclassified sequences" ]

[ 205, 17302, 6383, 1, 147 ]

5

[ "Danio rerio", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 9, 1, 2, 2 ]

4

true

Family

Diverse substrate methyltransferase

Diverse_substrate_MTase

8

IPR051053

51,053

Enoyl-CoA hydratase/isomerase and chromodomain-containing protein

ECH/Chromodomain_protein

Family

17,811

true

false

This family of proteins includes enzymes involved in various metabolic processes, such as the isomerization of enoyl-CoA species and the dehalogenation of halobenzoyl-CoA compounds. Members of this family exhibit activities like hydratase, isomerase, and dehalogenase, playing roles in fatty acid metabolism, biosynthesi...

[]

0

[ "PANTHER" ]

[ "PTHR43684" ]

[ "ECH/Chromodomain_protein" ]

[ 17811 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-CEL-390247", "R-CEL-9033241", "R-HSA-390247", "R-HSA-9033241", "R-MMU-390247", "R-MMU-9033241", "R-RNO-390247", "R-RNO-9033241", "R-SCE-390247", "R-SCE-9033241" ]

[ "REACTOME:R-CEL-390247", "REACTOME:R-CEL-9033241", "REACTOME:R-HSA-390247", "REACTOME:R-HSA-9033241", "REACTOME:R-MMU-390247", "REACTOME:R-MMU-9033241", "REACTOME:R-RNO-390247", "REACTOME:R-RNO-9033241", "REACTOME:R-SCE-390247", "REACTOME:R-SCE-9033241" ]

10

[ "1hno", "1hnu", "1jxz", "1k39", "1nzy", "1pjh", "2ej5", "2f6q", "2fbm", "2fw2", "2gtr", "3fdu", "3qmj", "3qre", "4nek", "4u18", "4u19", "4u1a", "4zdb", "4zdc", "4zdd", "4zde", "4zdf", "5ve2", "6ijk", "6lvo", "7bor", "7crd", "9fgz", "9fh0" ]

30

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Methanobacteriati", "Sym plasmid", "unclassified sequences" ]

[ 8096, 9380, 40, 1, 294 ]

5

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)" ]

[ 3, 9, 6, 18, 15, 1, 19, 2 ]

8

true

Family

Enoyl-CoA hydratase/isomerase and chromodomain-containing protein

ECH/Chromodomain_protein

8

IPR051054

51,054

Bacterial SorC Transcriptional Regulators

SorC_transcr_regulators

Family

18,959

true

false

The SorC transcriptional regulatory family is comprised of proteins that function as transcriptional regulators with diverse roles in bacterial gene expression. Members of this family typically act as repressors or activators of operons in response to specific inducers or environmental conditions. For instance, LsrR pr...

[]

0

[ "PANTHER" ]

[ "PTHR34294" ]

[ "SorC_transcr_regulators" ]

[ 18959 ]

1

[]

0

[ "2gnp", "2o0m", "2okg", "2r5f", "2w48", "3bxe", "3bxf", "3bxg", "3bxh", "3efb", "3kv1", "3nze", "4go1", "4l4y", "4l4z", "4l50", "4l51", "4l5i", "4l5j", "4oqp", "4oqq", "4r9n", "7bhy", "7oyk", "8r3g", "8r7y" ]

26

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 18837, 9, 113 ]

3

[ "Escherichia coli (strain K12)" ]

[ 2 ]

1

true

Family

Bacterial SorC Transcriptional Regulators

SorC_transcr_regulators

6

IPR051055

51,055

PIF1 DNA helicase

PIF1_helicase

Family

22,591

true

false

The PIF1 helicase family is characterized by DNA-dependent ATPase and 5'-3' DNA helicase activities that are essential for maintaining mitochondrial and nuclear genome stability. Members of the family are adept at unwinding G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids, which is crucial for preventing rep...

[]

0

[ "PANTHER" ]

[ "PTHR47642" ]

[ "PIF1_helicase" ]

[ 22591 ]

1

[ "EC", "REACTOME", "REACTOME", "REACTOME" ]

[ "5.6.2.3", "R-HSA-171319", "R-MMU-171319", "R-RNO-171319" ]

[ "EC:5.6.2.3", "REACTOME:R-HSA-171319", "REACTOME:R-MMU-171319", "REACTOME:R-RNO-171319" ]

4

[ "3upu", "5fhd", "5fhe", "5fhf", "5fhg", "5fhh", "5ftb", "5ftc", "5ftd", "5fte", "5ftf", "5o6b", "5o6d", "5o6e", "6hph", "6hpq", "6hpt", "6hpu", "6l3g", "6s3e", "6s3h", "6s3i", "6s3m", "6s3n", "6s3o", "6s3p", "6xzt", "7ada", "7bil", "7oar", "7otj", "8bns"...

39

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 5, 5107, 16832, 368, 279 ]

5

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strai...

[ 6, 33, 1, 2, 3, 3, 2, 2, 1 ]

9

true

Family

PIF1 DNA helicase

PIF1_helicase

2

IPR051056

51,056

Glycosyl Hydrolase Family 73

Glycosyl_Hydrolase_73

Family

15,666

true

false

The glycosyl hydrolase 73 family encompasses enzymes with diverse functions related to cell wall metabolism. Members of this family are involved in the endohydrolysis of the di-N-acetylchitobiosyl unit in high-mannose glycopeptides and glycoproteins, playing a crucial role in cell division by cleaving peptidoglycan and...

[]

0

[ "PANTHER" ]

[ "PTHR33308" ]

[ "Glycosyl_Hydrolase_73" ]

[ 15666 ]

1

[ "EC" ]

[ "3.2.1" ]

[ "EC:3.2.1" ]

1

[ "2zyc", "3fi7", "3k3t", "3vwo", "4q2w", "4qdn", "5dn4", "5dn5", "5jqc", "5t1q", "7pj3", "7pj4", "7pj5", "7pj6", "7pl2", "7pl3", "7pl5", "7pod", "7qfu" ]

19

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Stenosarchaea group", "Viruses", "unclassified sequences" ]

[ 15273, 15, 5, 246, 127 ]

5

[ "Arabidopsis thaliana", "Escherichia coli (strain K12)" ]

[ 1, 1 ]

2

true

Family

Glycosyl Hydrolase Family 73

Glycosyl_Hydrolase_73

9

IPR051057

51,057

Phosphoinositide phospholipase C domain-containing protein

PI-PLC_domain

Family

21,137

true

false

This family of proteins includes enzymes with phospholipase C activity, specifically involved in the hydrolysis of glycosylphosphatidylinositol (GPI) and phosphatidylinositol (PI) anchors. These proteins do not cleave PI phosphates. Members of this family are implicated in various biological processes, including the re...

[]

0

[ "PANTHER" ]

[ "PTHR13593" ]

[ "PI-PLC_domain" ]

[ 21137 ]

1

[]

0

[ "1aod", "1gym", "1ptd", "1ptg", "1t6m", "2or2", "2plc", "2ptd", "3ea1", "3ea2", "3ea3", "3ptd", "3v16", "3v18", "3v1h", "4f2b", "4f2t", "4f2u", "4i8y", "4i90", "4i9j", "4i9m", "4i9t", "4ptd", "4rv3", "4s3g", "5ptd", "6ptd", "6s2a", "7ptd" ]

30

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Methanobacteriati", "Viruses", "metagenomes" ]

[ 3297, 17783, 22, 7, 28 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 32, 1, 29, 6, 11, 8, 6, 17, 7, 31 ]

10

true

Family

Phosphoinositide phospholipase C domain-containing protein

PI-PLC_domain

4

IPR051058

51,058

GDSL Esterase/Lipase Enzyme

GDSL_Est/Lipase

Family

17,365

true

false

The GDSL lipolytic enzyme family is characterized by a broad range of esterase and lipase activities, acting on various substrates. Members of this family are involved in diverse biological processes, including lipid metabolism, cell signaling, and stress response. Some proteins within the family exhibit specific funct...

[]

0

[ "PANTHER" ]

[ "PTHR45648" ]

[ "GDSL_Est/Lipase" ]

[ 17365 ]

1

[ "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC"...

[ "3.1.1.-", "PWY-1921", "PWY-5835", "PWY-6190", "PWY-6308", "PWY-6322", "PWY-6339", "PWY-6415", "PWY-6558", "PWY-6848", "PWY-7002", "PWY-7352", "PWY-7367", "PWY-7521", "PWY-7599", "PWY-7660", "PWY-7712", "PWY-7713", "PWY-7730", "PWY-7769", "PWY-7982", "PWY-8058", "PWY-8143...

[ "EC:3.1.1.-", "METACYC:PWY-1921", "METACYC:PWY-5835", "METACYC:PWY-6190", "METACYC:PWY-6308", "METACYC:PWY-6322", "METACYC:PWY-6339", "METACYC:PWY-6415", "METACYC:PWY-6558", "METACYC:PWY-6848", "METACYC:PWY-7002", "METACYC:PWY-7352", "METACYC:PWY-7367", "METACYC:PWY-7521", "METACYC:PWY-7...

28

[ "6uqv", "6uqw", "6uqx", "6uqy", "6uqz", "6ur0", "6ur1", "7ztn", "8a24", "8a25", "8a26", "8d8w", "8d8x", "8d8y", "8d8z", "8d90", "8d91", "8p1g", "9l1r", "9l1t", "9l27", "9l2a", "9l2b", "9l2c", "9l2h", "9l2j", "9l2m", "9l2p", "9l34", "9l37", "9l39", "9l3a"...

33

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "ecological metagenomes", "environmental samples" ]

[ 3025, 14326, 12, 2 ]

4

[ "Arabidopsis thaliana", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 41, 1, 88, 114 ]

4

true

Family

GDSL Esterase/Lipase Enzyme

GDSL_Est/Lipase

3

IPR051060

51,060

Carbamoyltransferase HypF-like

Carbamoyltrans_HypF-like

Family

8,494

true

false

This family of proteins includes enzymes involved in the maturation of [NiFe] hydrogenases, a class of enzymes that catalyze the reversible oxidation of hydrogen gas. Members of this family function as carbamoyl transferases, utilizing carbamoylphosphate as a substrate. They transfer the carboxamido moiety in an ATP-de...

[]

0

[ "PANTHER" ]

[ "PTHR42959" ]

[ "Carbamoyltrans_HypF-like" ]

[ 8494 ]

1

[]

0

[ "1gxt", "1gxu", "3tsp", "3tsq", "3tsu", "3ttc", "3ttd", "3ttf", "3vth", "3vti", "4g9i", "7chx" ]

12

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "metagenomes" ]

[ 424, 7784, 10, 276 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Carbamoyltransferase HypF-like

Carbamoyltrans_HypF-like

7

IPR051062

51,062

DNA topoisomerase IB

Topoisomerase_IB

Family

12,146

true

false

The DNA topoisomerase IB family consists of enzymes that modulate the topological states of DNA by transiently breaking and rejoining one strand of the DNA duplex. They play a crucial role in releasing the supercoiling and torsional tension of DNA that arises during replication and transcription. These enzymes introduc...

[]

0

[ "PANTHER" ]

[ "PTHR10290" ]

[ "Topoisomerase_IB" ]

[ 12146 ]

1

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "5.6.2.1", "R-CEL-4615885", "R-DDI-4615885", "R-HSA-4615885", "R-MMU-4615885", "R-RNO-4615885", "R-SCE-4615885", "R-SPO-4615885" ]

[ "EC:5.6.2.1", "REACTOME:R-CEL-4615885", "REACTOME:R-DDI-4615885", "REACTOME:R-HSA-4615885", "REACTOME:R-MMU-4615885", "REACTOME:R-RNO-4615885", "REACTOME:R-SCE-4615885", "REACTOME:R-SPO-4615885" ]

8

[ "1a31", "1a35", "1a36", "1ej9", "1k4s", "1k4t", "1lpq", "1nh3", "1ois", "1r49", "1rr8", "1rrj", "1sc7", "1seu", "1t8i", "1tl8", "2b9s", "6z01", "6z03" ]

19

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Megaviricetes", "metagenomes" ]

[ 113, 329, 11625, 36, 43 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 18, 1, 7, 7, 21, 7, 2, 2, 10, 1, 1, 26 ]

12

true

Family

DNA topoisomerase IB

Topoisomerase_IB

4

IPR051063

51,063

Protein Disulfide Isomerase

PDI

Family

10,262

true

false

The protein disulfide isomerase family is involved in the formation, isomerization, and reduction or oxidation of disulfide bonds in proteins within the endoplasmic reticulum lumen. Members of this family act as protein-folding catalysts, interacting with nascent polypeptides to facilitate proper folding and stabilizat...

[]

0

[ "PANTHER" ]

[ "PTHR45672" ]

[ "PDI" ]

[ 10262 ]

1

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "5.3.4.1", "R-DME-432720", "R-DME-6798695", "R-HSA-381038", "R-HSA-432720", "R-HSA-432722", "R-HSA-6798695", "R-MMU-432720", "R-MMU-432722", "R-MMU-6798695", "R-SCE-6798695" ]

[ "EC:5.3.4.1", "REACTOME:R-DME-432720", "REACTOME:R-DME-6798695", "REACTOME:R-HSA-381038", "REACTOME:R-HSA-432720", "REACTOME:R-HSA-432722", "REACTOME:R-HSA-6798695", "REACTOME:R-MMU-432720", "REACTOME:R-MMU-432722", "REACTOME:R-MMU-6798695", "REACTOME:R-SCE-6798695" ]

11

[ "2diz", "3h79", "3uj1", "3uvt", "3wgd", "3wge", "3wgx", "4tve", "4tw5", "8eky" ]

10

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "metagenomes" ]

[ 8, 67, 9908, 68, 211 ]

5

[ "Arabidopsis thaliana", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "...

[ 9, 3, 4, 7, 8, 1, 5, 10, 2, 1, 56 ]

11

true

Family

Protein Disulfide Isomerase

PDI

4

IPR051065

51,065

Ras-related small GTPase

Ras-related_GTPase

Family

9,273

true

false

This family of proteins includes members that are part of the small GTPase superfamily, specifically within the Ras subfamily. These proteins are involved in various cellular processes through their ability to bind and hydrolyze GTP. They act as molecular switches that cycle between active GTP-bound and inactive GDP-bo...

[]

0

[ "PANTHER" ]

[ "PTHR45704" ]

[ "Ras-related_GTPase" ]

[ 9273 ]

1

[ "EC" ]

[ "3.6.5.2" ]

[ "EC:3.6.5.2" ]

1

[ "2atv", "3c5c", "5c1t" ]

3

[]

0

[]

0

null

[ "Eukaryota" ]

[ 9273 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus" ]

[ 1, 21, 3, 11, 8, 1, 18 ]

7

true

Family

Ras-related small GTPase

Ras-related_GTPase

8

IPR051066

51,066

Transcriptional Regulator and Corepressor

Trans_reg/Corepressor

Family

8,599

true

false

This family of proteins includes transcriptional regulators and corepressors that are involved in the modulation of gene expression through chromatin remodeling. Members of this family are known to bind DNA and activate or repress transcription of specific target genes. They are involved in various biological processes...

[]

0

[ "PANTHER" ]

[ "PTHR16089" ]

[ "Trans_reg/Corepressor" ]

[ 8599 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-DME-3214815", "R-DME-983231", "R-HSA-3214815", "R-HSA-8943724", "R-HSA-9679191", "R-HSA-983231", "R-MMU-3214815", "R-MMU-983231" ]

[ "REACTOME:R-DME-3214815", "REACTOME:R-DME-983231", "REACTOME:R-HSA-3214815", "REACTOME:R-HSA-8943724", "REACTOME:R-HSA-9679191", "REACTOME:R-HSA-983231", "REACTOME:R-MMU-3214815", "REACTOME:R-MMU-983231" ]

8

[ "2iw5", "2uxn", "2uxx", "2v1d", "2x0l", "2xaf", "2xag", "2xah", "2xaj", "2xaq", "2xas", "2y48", "3zms", "3zmt", "3zmu", "3zmv", "3zmz", "3zn0", "3zn1", "4bay", "4czz", "4kum", "4uv8", "4uv9", "4uva", "4uvb", "4uvc", "4uxn", "4xbf", "5h6q", "5h6r", "5l3b"...

104

[]

0

[]

0

null

[ "Eukaryota", "bird metagenome" ]

[ 8598, 1 ]

2

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 8, 29, 11, 19, 17, 23 ]

6

true

Family

Transcriptional Regulator and Corepressor

Trans_reg/Corepressor

7

IPR051067

51,067

Na+/H+ exchange regulatory cofactor

NHER

Family

7,823

true

false

The NHER family comprises scaffold proteins that regulate the surface expression and function of various membrane proteins, linking them to the actin cytoskeleton. They are involved in ion transport, second messenger cascades, and may enhance Wnt signaling. Some family members interact with regulatory components like N...

[]

0

[ "PANTHER" ]

[ "PTHR14191" ]

[ "NHER" ]

[ 7823 ]

1

[ "REACTOME" ]

[ "R-HSA-8942233" ]

[ "REACTOME:R-HSA-8942233" ]

1

[ "1g9o", "1gq4", "1gq5", "1i92", "2d90", "2edz", "2eei", "2eej", "2he4", "2jxo", "2kjd", "2kqf", "2krg", "2kyl", "2m0t", "2m0u", "2m0v", "2ocs", "2ozf", "2v90", "2vsp", "2w7r", "3khf", "3ngh", "3ps4", "3r68", "3r69", "3tmh", "4f8k", "4jl7", "4lmm", "4mpa"...

41

[]

0

[]

0

null

[ "Eukaryota", "FCB group", "bioreactor metagenome" ]

[ 7803, 19, 1 ]

3

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 20, 1, 19, 19, 15 ]

6

true

Family

Na+/H+ exchange regulatory cofactor

NHER

7

IPR051068

51,068

Major Facilitator Superfamily Domain-Containing Protein

MFS_Domain-Containing_Protein

Family

8,063

true

false

This family of proteins is part of the major facilitator superfamily (MFS), which is one of the largest groups of secondary transporters. Members of this family are involved in a variety of cellular processes, including the transport of small solutes across cell membranes. They function by utilizing chemiosmotic ion gr...

[]

0

[ "PANTHER" ]

[ "PTHR23510" ]

[ "MFS_Domain-Containing_Protein" ]

[ 8063 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Caminibacter mediatlanticus TB-2", "Eukaryota" ]

[ 1, 8062 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)", "Zea mays" ]

[ 17, 20, 10, 1, 32, 2, 5, 5, 4, 30 ]

10

true

Family

Major Facilitator Superfamily Domain-Containing Protein

MFS_Domain-Containing_Protein

6

IPR051069

51,069

Acetyl-CoA decarbonylase/synthase complex subunit

ACDS_complex_subunit

Family

2,019

true

false

The CdhD family is involved in the reversible cleavage of acetyl-CoA, which is a critical step in autotrophic growth from CO2 and growth on acetate as the sole source of carbon and energy. Members of the family are part of a larger acetyl-CoA decarbonylase/synthase (ACDS) complex, contributing to the complex's quaterna...

[]

0

[ "PANTHER" ]

[ "PTHR36214" ]

[ "ACDS_complex_subunit" ]

[ 2019 ]

1

[]

0

[ "2h9a", "2ycl", "4c1n", "4djd", "4dje", "4djf", "9fzy", "9fzz", "9g00" ]

9

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Cyprideis torosa", "unclassified sequences" ]

[ 755, 1095, 2, 167 ]

4

[]

0

true

Family

Acetyl-CoA decarbonylase/synthase complex subunit

ACDS_complex_subunit

1

IPR051071

51,071

Leucine-rich repeat-containing bacterial E3 ubiquitin ligases

LRR-bact_E3_ubiq_ligases

Family

5,139

true

false

The LRR-containing bacterial E3 ligase family comprises effector E3 ubiquitin ligases that manipulate the host's ubiquitination pathway to promote bacterial survival within host tissues. These proteins typically exist in an autoinhibited state and are activated upon substrate binding. They are known to ubiquitinate var...

[]

0

[ "PANTHER" ]

[ "PTHR47114" ]

[ "LRR-bact_E3_ubiq_ligases" ]

[ 5139 ]

1

[ "EC", "METACYC", "REACTOME", "REACTOME" ]

[ "2.3.2.27", "PWY-7511", "R-HSA-193634", "R-MMU-193634" ]

[ "EC:2.3.2.27", "METACYC:PWY-7511", "REACTOME:R-HSA-193634", "REACTOME:R-MMU-193634" ]

4

[ "1g9u", "1jl5", "3ckd", "3cvr", "3g06", "3l3p", "4nkg", "4nkh", "4ow2", "4puf", "5b0n", "5b0t", "5kh1", "6k2d", "6loj", "6lol", "7v8e", "7v8g", "7v8h", "7wjq", "7ya7", "7ya8", "8efp", "8gtj", "8gtk", "9g08", "9g09", "9h6w", "9jta", "9jwg" ]

30

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Viruses", "metagenomes" ]

[ 3782, 1216, 46, 95 ]

4

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 3, 3, 4, 4 ]

4

true

Family

Leucine-rich repeat-containing bacterial E3 ubiquitin ligases

LRR-bact_E3_ubiq_ligases

6

IPR051072

51,072

Voltage-dependent calcium channel gamma subunit

CACNG_subunit

Family

6,482

true

false

This family of proteins is involved in the regulation of ion channel trafficking and gating properties, particularly for AMPA-selective glutamate receptors (AMPARs) and L-type calcium channels. They play a role in promoting the targeting of AMPARs to the cell membrane and synapses, as well as modulating their activatio...

[]

0

[ "PANTHER" ]

[ "PTHR12107" ]

[ "CACNG_subunit" ]

[ 6482 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-399719", "R-BTA-5682910", "R-HSA-112308", "R-HSA-399719", "R-HSA-5576892", "R-HSA-5576893", "R-HSA-5682910", "R-HSA-9856532", "R-MMU-112308", "R-MMU-399719", "R-MMU-5576892", "R-MMU-5576893", "R-MMU-5682910", "R-RNO-112308", "R-RNO-399719", "R-RNO-5576892", "R-RNO-5576893", ...

[ "REACTOME:R-BTA-399719", "REACTOME:R-BTA-5682910", "REACTOME:R-HSA-112308", "REACTOME:R-HSA-399719", "REACTOME:R-HSA-5576892", "REACTOME:R-HSA-5576893", "REACTOME:R-HSA-5682910", "REACTOME:R-HSA-9856532", "REACTOME:R-MMU-112308", "REACTOME:R-MMU-399719", "REACTOME:R-MMU-5576892", "REACTOME:R-M...

18

[ "5kk2", "5vot", "5vou", "5vov", "6njl", "6njm", "6njn", "6qkc", "6qkz", "7ldd", "7lde", "7lep", "7oca", "7ocd", "7oce", "7ocf", "7qhb", "7qhh", "8ayl", "8aym", "8ayn", "8ayo", "8c1p", "8c1q", "8c1r", "8c1s", "8c2h", "8c2i", "8fp4", "8fp9", "8fpg", "8fps"...

74

[]

0

[]

0

null

[ "Bilateria" ]

[ 6482 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 20, 2, 12, 16, 14 ]

6

true

Family

Voltage-dependent calcium channel gamma subunit

CACNG_subunit

9

IPR051073

51,073

ZNRF3/Arkadia E3 ubiquitin-protein ligases

ZNRF3_Arkadia_E3_ligases

Family

6,665

true

false

The ZNRF3/Arkadia protein family comprises E3 ubiquitin-protein ligases that play crucial roles in regulating the Wnt signaling pathway and the BMP-SMAD signaling axis. Members of the family mediate the ubiquitination and subsequent degradation of key components in these pathways, such as Wnt receptor complex component...

[]

0

[ "PANTHER" ]

[ "PTHR16200" ]

[ "ZNRF3_Arkadia_E3_ligases" ]

[ 6665 ]

1

[ "EC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "2.3.2.27", "PWY-7511", "R-CEL-4641263", "R-DRE-4641263", "R-HSA-2173795", "R-HSA-2173796", "R-HSA-4641263", "R-HSA-5340588", "R-HSA-5689880", "R-HSA-5689896", "R-HSA-5696395", "R-HSA-983168", "R-MMU-2173796", "R-MMU-4641263", "R-MMU-5689880", "R-MMU-5689896", "R-MMU-5696395", "R-M...

[ "EC:2.3.2.27", "METACYC:PWY-7511", "REACTOME:R-CEL-4641263", "REACTOME:R-DRE-4641263", "REACTOME:R-HSA-2173795", "REACTOME:R-HSA-2173796", "REACTOME:R-HSA-4641263", "REACTOME:R-HSA-5340588", "REACTOME:R-HSA-5689880", "REACTOME:R-HSA-5689896", "REACTOME:R-HSA-5696395", "REACTOME:R-HSA-983168", ...

20

[ "4c84", "4c85", "4c86", "4c8a", "4c8c", "4c8f", "4c8p", "4c8t", "4c8u", "4c99", "4c9a", "4c9e", "4c9r", "4c9u", "4c9v", "4cdj", "4cdk", "4kng", "4ufs", "8g4y", "8wvu", "8xfp", "8xfs", "8xft", "8y69", "9kb8", "9kb9" ]

27

[]

0

[]

0

null

[ "Eukaryota" ]

[ 6665 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 20, 19, 15, 18 ]

5

true

Family

ZNRF3/Arkadia E3 ubiquitin-protein ligases

ZNRF3_Arkadia_E3_ligases

8

IPR051074

51,074

Sorting Nexin

Sorting_Nexin

Family

4,626

true

false

The Sorting Nexin family is involved in intracellular trafficking, endosomal sorting, and membrane protein retention. Members of this family play a role in the retention of late Golgi membrane proteins and are part of the retrieval machinery interacting with TGN membrane proteins. They bind phosphatidylinositol 3-phosp...

[]

0

[ "PANTHER" ]

[ "PTHR45963" ]

[ "Sorting_Nexin" ]

[ 4626 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-3238698", "R-HSA-3238698", "R-HSA-5689880", "R-MMU-3238698", "R-MMU-5689880", "R-RNO-3238698", "R-RNO-5689880", "R-SCE-3238698", "R-SCE-5689880", "R-SPO-3238698", "R-SPO-5689880" ]

[ "REACTOME:R-BTA-3238698", "REACTOME:R-HSA-3238698", "REACTOME:R-HSA-5689880", "REACTOME:R-MMU-3238698", "REACTOME:R-MMU-5689880", "REACTOME:R-RNO-3238698", "REACTOME:R-RNO-5689880", "REACTOME:R-SCE-3238698", "REACTOME:R-SCE-5689880", "REACTOME:R-SPO-3238698", "REACTOME:R-SPO-5689880" ]

11

[ "1ocs", "1ocu", "2csk", "2mxc", "2yps", "5f0j", "5f0l", "5f0m", "5f0p", "7blo", "7blq" ]

11

[]

0

[]

0

null

[ "Eukaryota" ]

[ 4626 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strai...

[ 1, 8, 1, 4, 10, 1, 12, 1, 1 ]

9

true

Family

Sorting Nexin

Sorting_Nexin

2

IPR051076

51,076

Golgi apparatus membrane protein TVP38/TMEM64

Golgi_membrane_TVP38/TMEM64

Family

3,122

true

false

The TVP38/TMEM64 family comprises Golgi apparatus membrane proteins that are implicated in vesicular trafficking and spindle migration. The proteins within this family are characterized by the presence of a VTT domain, which was previously known as the SNARE-assoc domain but was renamed due to the lack of evidence for ...

[]

0

[ "PANTHER" ]

[ "PTHR47549" ]

[ "Golgi_membrane_TVP38/TMEM64" ]

[ 3122 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Eukaryota" ]

[ 3122 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 1, 1 ]

3

true

Family

Golgi apparatus membrane protein TVP38/TMEM64

Golgi_membrane_TVP38/TMEM64

5

IPR051077

51,077

Calcium-dependent Lectin

Ca-dependent_lectin

Family

4,770

true

false

This family of proteins includes calcium-dependent lectins that play a crucial role in the innate immune defense. They are responsible for binding specific carbohydrate moieties such as mannose, fucose, and N-acetylglucosamine present on the surfaces of various microorganisms, which leads to the activation of the lecti...

[]

0

[ "PANTHER" ]

[ "PTHR24024" ]

[ "Ca-dependent_lectin" ]

[ 4770 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-166016", "R-BTA-166662", "R-BTA-166663", "R-BTA-198933", "R-BTA-3000480", "R-BTA-391160", "R-BTA-5683826", "R-BTA-5686938", "R-GGA-166662", "R-GGA-166663", "R-GGA-2132263", "R-GGA-2132270", "R-HSA-166016", "R-HSA-166662", "R-HSA-166663", "R-HSA-168179", "R-HSA-198933", "R-HS...

[ "REACTOME:R-BTA-166016", "REACTOME:R-BTA-166662", "REACTOME:R-BTA-166663", "REACTOME:R-BTA-198933", "REACTOME:R-BTA-3000480", "REACTOME:R-BTA-391160", "REACTOME:R-BTA-5683826", "REACTOME:R-BTA-5686938", "REACTOME:R-GGA-166662", "REACTOME:R-GGA-166663", "REACTOME:R-GGA-2132263", "REACTOME:R-GGA...

45

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Viruses" ]

[ 14, 4754, 2 ]

3

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 10, 4, 7, 19 ]

4

true

Family

Calcium-dependent Lectin

Ca-dependent_lectin

7

IPR051078

51,078

SAGA-associated factor 11

SGF11

Family

2,324

true

false

The SGF11 family proteins are components of the SAGA complex, a transcription regulatory histone acetylation (HAT) complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Members of the SGF11 family participate in a subcomplex of SAGA that specifically deubiq...

[]

0

[ "PANTHER" ]

[ "PTHR46367" ]

[ "SGF11" ]

[ 2324 ]

1

[ "REACTOME" ]

[ "R-HSA-3214847" ]

[ "REACTOME:R-HSA-3214847" ]

1

[ "2kkt" ]

1

[]

0

[]

0

null

[ "Eukaryota", "Lactobacillus equicursoris", "bird metagenome" ]

[ 2321, 2, 1 ]

3

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 6, 1, 7, 3, 4, 1 ]

6

true

Family

SAGA-associated factor 11

SGF11

9

IPR051080

51,080

Nematode receptor-like serpentine class alpha

Nematode_rcpt-like_serp_alpha

Family

846

true

false

This family of proteins includes G protein-coupled receptors (GPCRs) that are involved in chemosensory processes. Members of this family are implicated in the negative regulation of RAS/MAPK signaling pathways during certain developmental processes, such as vulva induction. They also play a role in the olfactory system...

[]

0

[ "PANTHER" ]

[ "PTHR31357" ]

[ "Nematode_rcpt-like_serp_alpha" ]

[ 846 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Nematoda" ]

[ 846 ]

1

[ "Caenorhabditis elegans" ]

[ 27 ]

1

true

Family

Nematode receptor-like serpentine class alpha

Nematode_rcpt-like_serp_alpha

3

IPR051081

51,081

HTH-type Metal-responsive Transcriptional Regulators

HTH_MetalResp_TranReg

Family

65,514

true

false

The protein family is comprised of helix-turn-helix (HTH) type transcriptional regulators involved in various cellular responses to environmental and intracellular signals. Members of the family function primarily as repressors or activators of gene expression. Several proteins within the family are responsive to metal...

[]

0

[ "PANTHER" ]

[ "PTHR33154" ]

[ "HTH_MetalResp_TranReg" ]

[ 65514 ]

1

[]

0

[ "1uly", "2cwe", "2kko", "2p4w", "2qlz", "2quf", "3f6v", "3gw2", "3jth", "4k2e", "4ooi", "5znx", "6j0e", "7p6f", "7txm", "7txn", "7txo" ]

17

[]

0

[]

[ "IPR047796", "IPR048226" ]

0

2

0

[ "Archaea", "Bacteria", "Caudoviricetes", "Eukaryota", "unclassified sequences" ]

[ 1925, 62977, 2, 19, 591 ]

5

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

HTH-type Metal-responsive Transcriptional Regulators

HTH_MetalResp_TranReg

2

IPR051082

51,082

Pentapeptide repeat and BTB/POZ domain-containing protein

Pentapeptide-BTB/POZ_domain

Family

32,722

true

false

This family of proteins includes members that are involved in various cellular processes, such as resistance to antibiotics, particularly fluoroquinolones, by inhibiting DNA gyrase activity. Some proteins in this family mimic B-form DNA, potentially protecting DNA gyrase from fluoroquinolone action. Others are implicat...

[]

0

[ "PANTHER" ]

[ "PTHR14136" ]

[ "Pentapeptide-BTB/POZ_domain" ]

[ 32722 ]

1

[]

0

[ "2bm4", "2bm5", "2bm6", "2bm7", "2j8i", "2o6w", "2xtw", "2xtx", "2xty", "3naw", "3nb2", "3pss", "3psz", "3sqv", "4yc5", "4ycq", "4ydt", "4yei", "4yfo", "5di5", "5dn0", "5dns", "5dqa", "5dra", "5dzb", "6omx", "6uv7", "6uvi", "6zt4", "6zt5" ]

30

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 496, 26958, 4516, 142, 610 ]

5

[ "Arabidopsis thaliana", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 5, 2, 2, 2, 2, 4, 6, 4, 6 ]

9

true

Family

Pentapeptide repeat and BTB/POZ domain-containing protein

Pentapeptide-BTB/POZ_domain

9

IPR051083

51,083

Group II Intron Splicing and Mobility/Defense

GrpII_Intron_Splice-Mob/Def

Family

30,284

true

false

The protein family includes multifunctional proteins that promote group II intron splicing and mobility, acting on both RNA and DNA. They have reverse transcriptase (RT) activity for intron duplication, maturase activity to facilitate splicing, and DNA endonuclease activity for site-specific DNA cleavage. Some members ...

[]

0

[ "PANTHER" ]

[ "PTHR34047" ]

[ "GrpII_Intron_Splice-Mob/Def" ]

[ 30284 ]

1

[ "EC" ]

[ "2.7.7.49" ]

[ "EC:2.7.7.49" ]

1

[ "5g2x", "5hhj", "5hhk", "5hhl", "5irf", "5irg", "6ar1", "6ar3", "6me0", "6mec", "7d0f", "7d0g", "7d1a", "7k9y", "7uim", "7uin", "7v9u", "7v9x", "7xjg", "8bgj", "8fli", "8h2h", "8qbk", "8qbl", "8qbm", "8t2r", "8t2s", "8t2t", "8ub7", "8ub8", "8ub9", "8uba"...

62

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "IncL/M plasmid R471a", "Viruses", "unclassified sequences" ]

[ 325, 27463, 1749, 1, 139, 607 ]

6

[ "Arabidopsis thaliana", "Escherichia coli (strain K12)", "Oryza sativa subsp. japonica", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)", "Zea mays" ]

[ 6, 1, 6, 1, 9 ]

5

true

Family

Group II Intron Splicing and Mobility/Defense

GrpII_Intron_Splice-Mob/Def

2

IPR051084

51,084

Proton-coupled symporters

H+-coupled_symporters

Family

35,761

true

false

This family of proteins is involved in the transport of various substrates across cellular membranes through a symport mechanism, where the transport of the substrate is coupled with the movement of protons into the cell. Members of this family function as osmosensors and osmoregulators, responding to osmotic shifts by...

[]

0

[ "PANTHER" ]

[ "PTHR43528" ]

[ "H+-coupled_symporters" ]

[ 35761 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Burkholderia phage phi1026b", "Eukaryota", "Sym plasmid", "unclassified sequences" ]

[ 167, 35039, 1, 502, 1, 51 ]

6

[ "Escherichia coli (strain K12)" ]

[ 2 ]

1

true

Family

Proton-coupled symporters

H+-coupled_symporters

2

IPR051085

51,085

Membrane-bound O-acyltransferase

MB_O-acyltransferase

Family

23,973

true

false

This family of proteins includes membrane-bound O-acyltransferases that are involved in various lipid modification processes. Members of this family are responsible for the acylation of proteins and lipids, which is crucial for their function and localization. Some proteins in this family catalyze the remodeling of gly...

[]

0

[ "PANTHER" ]

[ "PTHR13285" ]

[ "MB_O-acyltransferase" ]

[ 23973 ]

1

[ "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC"...

[ "2.3.1.-", "PWY-3602", "PWY-361", "PWY-4801", "PWY-4922", "PWY-5048", "PWY-5139", "PWY-5268", "PWY-5284", "PWY-5292", "PWY-5307", "PWY-5313", "PWY-5317", "PWY-5318", "PWY-5353", "PWY-5400", "PWY-5473", "PWY-5475", "PWY-5477", "PWY-5660", "PWY-5679", "PWY-5710", "PWY-5794"...

[ "EC:2.3.1.-", "METACYC:PWY-3602", "METACYC:PWY-361", "METACYC:PWY-4801", "METACYC:PWY-4922", "METACYC:PWY-5048", "METACYC:PWY-5139", "METACYC:PWY-5268", "METACYC:PWY-5284", "METACYC:PWY-5292", "METACYC:PWY-5307", "METACYC:PWY-5313", "METACYC:PWY-5317", "METACYC:PWY-5318", "METACYC:PWY-53...

224

[ "6bug", "6buh", "6bui", "7mhy", "7mhz", "7q1u", "7q6z", "7urf", "8jem", "8jes", "8jf2" ]

11

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Caudoviricetes", "Eukaryota", "unclassified sequences" ]

[ 20, 16720, 2, 6997, 234 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 5, 2, 6, 2, 15, 6, 2, 4, 8, 2, 1, 16 ]

12

true

Family

Membrane-bound O-acyltransferase

MB_O-acyltransferase

7

IPR051086

51,086

Ribonuclease D-like

RNase_D-like

Family

17,557

true

false

This family of proteins is involved in the post-transcriptional modification of precursor tRNA molecules. Members of this family function as exonucleases, initiating the hydrolysis of RNA at the 3'-terminus and subsequently releasing 5'-mononucleotides. This enzymatic activity is essential for the proper processing of ...

[]

0

[ "PANTHER" ]

[ "PTHR47649" ]

[ "RNase_D-like" ]

[ 17557 ]

1

[ "EC" ]

[ "3.1.13.5" ]

[ "EC:3.1.13.5" ]

1

[ "1yt3", "3cym", "5zo3", "5zo4", "5zo5", "7mpl", "7mpm", "7mpn", "7mpo", "7mpp", "7mpq", "7mpr", "7mps", "7mpt", "7mpu", "7mqb", "7mqc", "7mqd", "7mqe", "7mqf", "7mqg", "7mqh", "7mqi", "9f7d", "9f7g", "9f7j", "9f7l" ]

27

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 3, 17058, 61, 435 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Ribonuclease D-like

RNase_D-like

7

IPR051087

51,087

Mitochondrial Acyl-CoA Synthetase Medium-Chain

Mitochondrial_ACSM

Family

16,578

true

false

The ACSM family catalyzes the activation of fatty acids by CoA to form acyl-CoA, a crucial step in fatty acid metabolism. Members of this family are capable of activating medium-chain fatty acids, with some showing specificity for C6-12 fatty acids or a preference for isobutyrate among C2-6 fatty acids. Additionally, c...

[]

0

[ "PANTHER" ]

[ "PTHR43605" ]

[ "Mitochondrial_ACSM" ]

[ 16578 ]

1

[ "EC", "EC", "METACYC", "METACYC", "METACYC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "6.2.1", "6.2.1.2", "PWY-5140", "PWY-7948", "PWY-8181", "PWY-8182", "R-HSA-177128", "R-HSA-177135", "R-HSA-177162", "R-HSA-77352", "R-HSA-9749641", "R-MMU-177128", "R-MMU-177135", "R-MMU-177162", "R-MMU-9749641", "R-RNO-177128", "R-RNO-177135", "R-RNO-177162", "R-RNO-9749641" ]

[ "EC:6.2.1", "EC:6.2.1.2", "METACYC:PWY-5140", "METACYC:PWY-7948", "METACYC:PWY-8181", "METACYC:PWY-8182", "REACTOME:R-HSA-177128", "REACTOME:R-HSA-177135", "REACTOME:R-HSA-177162", "REACTOME:R-HSA-77352", "REACTOME:R-HSA-9749641", "REACTOME:R-MMU-177128", "REACTOME:R-MMU-177135", "REACTOME...

19

[ "2vze", "2wd9", "3b7w", "3c5e", "3day", "3eq6", "3etc", "3gpc", "5u2a", "8biq", "8bit" ]

11

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 899, 11514, 3989, 176 ]

4

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 40, 15, 26 ]

4

true

Family

Mitochondrial Acyl-CoA Synthetase Medium-Chain

Mitochondrial_ACSM

8

IPR051088

51,088

Bacterial PTS System Sugar-Specific EIIC/EIIB

PTS_Sugar-EIIC/EIIB

Family

16,861

true

false

The protein family is involved in the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), which is a key carbohydrate transport and phosphorylation mechanism in bacteria. Members of the family function as integral membrane proteins that form the translocation channel for specific sugars, facilitating t...

[]

0

[ "PANTHER" ]

[ "PTHR33989" ]

[ "PTS_Sugar-EIIC/EIIB" ]

[ 16861 ]

1

[ "EC" ]

[ "2.7.1.207" ]

[ "EC:2.7.1.207" ]

1

[ "3qnq" ]

1

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 16806, 9, 46 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Bacterial PTS System Sugar-Specific EIIC/EIIB

PTS_Sugar-EIIC/EIIB

1

IPR051090

51,090

Inositol Monophosphatase Superfamily

Inositol_monoP_superfamily

Family

12,421

true

false

The inositol monophosphatase superfamily is characterized by its ability to dephosphorylate various substrates, playing a crucial role in different metabolic pathways. Members of this family are involved in the sulfur-activation pathway, converting adenosine 3'-phosphate 5'-phosphosulfate (PAPS) to adenosine 5'-phospho...

[]

0

[ "PANTHER" ]

[ "PTHR43200" ]

[ "Inositol_monoP_superfamily" ]

[ 12421 ]

1

[ "EC" ]

[ "3.1.3.7" ]

[ "EC:3.1.3.7" ]

1

[ "1k9y", "1k9z", "1ka0", "1ka1", "1qgx", "4hxv", "4n81", "4o7i", "5eq7", "5eq8", "5eq9", "5eqa", "5t3j", "8f9y" ]

14

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 5432, 6883, 106 ]

3

[ "Arabidopsis thaliana", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)", "Zea mays" ]

[ 30, 3, 23, 1, 1, 34 ]

6

true

Family

Inositol Monophosphatase Superfamily

Inositol_monoP_superfamily

1

IPR051091

51,091

Protein O-Glucosyltransferase/Glycosyltransferase 90

O-Glucosyltr/Glycosyltrsf_90

Family

19,145

true

false

The protein family is involved in the post-translational modification of proteins through O-glycosylation, specifically targeting extracellular EGF repeats and other consensus sequence motifs. Members of the family function as glycosyltransferases, transferring glucose or xylose from UDP-sugars to serine residues withi...

[]

0

[ "PANTHER" ]

[ "PTHR12203" ]

[ "O-Glucosyltr/Glycosyltrsf_90" ]

[ 19145 ]

1

[ "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC"...

[ "2.4.1.-", "PWY-1901", "PWY-1961", "PWY-1981", "PWY-2021", "PWY-2881", "PWY-2901", "PWY-2902", "PWY-4421", "PWY-4801", "PWY-5094", "PWY-5105", "PWY-5129", "PWY-5139", "PWY-5160", "PWY-5161", "PWY-5268", "PWY-5284", "PWY-5286", "PWY-5310", "PWY-5312", "PWY-5313", "PWY-5317...

[ "EC:2.4.1.-", "METACYC:PWY-1901", "METACYC:PWY-1961", "METACYC:PWY-1981", "METACYC:PWY-2021", "METACYC:PWY-2881", "METACYC:PWY-2901", "METACYC:PWY-2902", "METACYC:PWY-4421", "METACYC:PWY-4801", "METACYC:PWY-5094", "METACYC:PWY-5105", "METACYC:PWY-5129", "METACYC:PWY-5139", "METACYC:PWY-5...

201

[ "5f84", "5f85", "5f86", "5f87", "5l0r", "5l0s", "5l0t", "5l0u", "5l0v", "5ub5" ]

10

[]

0

[]

0

null

[ "Bacteria", "Candidatus Lokiarchaeum ossiferum", "Eukaryota", "Viruses", "metagenomes" ]

[ 972, 1, 17990, 103, 79 ]

5

[ "Arabidopsis thaliana", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 57, 6, 6, 14, 6, 5, 21, 10, 27 ]

9

true

Family

Protein O-Glucosyltransferase/Glycosyltransferase 90

O-Glucosyltr/Glycosyltrsf_90

9

IPR051092

51,092

FYVE, RhoGEF and PH domain-containing

FYVE_RhoGEF_PH

Family

16,382

true

false

The FYVE, RhoGEF and PH domain-containing protein family is involved in the regulation of the actin cytoskeleton and cell shape. Members of this family activate CDC42, a Ras-like Rho family GTPase, by facilitating the exchange of bound GDP for free GTP. This activation process is crucial for various cellular functions ...

[]

0

[ "PANTHER" ]

[ "PTHR12673" ]

[ "FYVE_RhoGEF_PH" ]

[ 16382 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-CEL-9013149", "R-DDI-5673000", "R-DDI-5675221", "R-HSA-193648", "R-HSA-416482", "R-HSA-9013148", "R-HSA-9013149", "R-MMU-193648", "R-MMU-416482", "R-MMU-9013148", "R-MMU-9013149", "R-RNO-193648", "R-RNO-416482", "R-RNO-9013148" ]

[ "REACTOME:R-CEL-9013149", "REACTOME:R-DDI-5673000", "REACTOME:R-DDI-5675221", "REACTOME:R-HSA-193648", "REACTOME:R-HSA-416482", "REACTOME:R-HSA-9013148", "REACTOME:R-HSA-9013149", "REACTOME:R-MMU-193648", "REACTOME:R-MMU-416482", "REACTOME:R-MMU-9013148", "REACTOME:R-MMU-9013149", "REACTOME:R-...

14

[ "1awe", "1dbh", "1pms", "1wgq", "3mpx", "8zlf", "9jb3" ]

7

[]

0

[]

0

null

[ "Eukaryota", "Pseudomonadati", "viral metagenome" ]

[ 16366, 15, 1 ]

3

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 7, 48, 3, 41, 25, 1, 33, 1 ]

8

true

Family

FYVE, RhoGEF and PH domain-containing

FYVE_RhoGEF_PH

7

IPR051093

51,093

Neuroligin and Bile salt-activated lipase

Neuroligin/BSAL

Family

17,135

true

false

This family of proteins includes cell surface molecules involved in cell-cell interactions, particularly in the nervous system. Members of this family interact with neurexin family proteins to mediate synapse function and synaptic signal transmission. They play roles in the formation and maintenance of synaptic junctio...

[]

0

[ "PANTHER" ]

[ "PTHR43903" ]

[ "Neuroligin/BSAL" ]

[ 17135 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-CEL-192456", "R-CEL-6794361", "R-HSA-192456", "R-HSA-6794361", "R-HSA-9925561", "R-MMU-192456", "R-MMU-6794361", "R-RNO-192456", "R-RNO-6794361" ]

[ "REACTOME:R-CEL-192456", "REACTOME:R-CEL-6794361", "REACTOME:R-HSA-192456", "REACTOME:R-HSA-6794361", "REACTOME:R-HSA-9925561", "REACTOME:R-MMU-192456", "REACTOME:R-MMU-6794361", "REACTOME:R-RNO-192456", "REACTOME:R-RNO-6794361" ]

9

[ "1akn", "1aql", "1f6w", "1jmy", "2bce", "2wqz", "2xb6", "3b3q", "3be8", "3biw", "3bix", "3bl8", "3vkf", "5oj6", "5ojk", "5v5v", "5xeq", "6h0t", "6h0v", "6h18", "6h19", "6h1a", "7cee", "7ceg", "8g7d", "8g7y", "8g7z", "8g80", "8g81", "8gs3", "8gs4" ]

31

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "marine metagenome" ]

[ 47, 17086, 2 ]

3

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 13, 60, 20, 44, 30, 22 ]

6

true

Family

Neuroligin and Bile salt-activated lipase

Neuroligin/BSAL

4

IPR051095

51,095

Drosophila Developmental Transcription Regulators

Dros_DevTransReg

Family

15,619

true

false

The protein family includes transcriptional regulators involved in various developmental processes in Drosophila melanogaster. Members act as transcriptional activators or repressors, influencing gene expression for segment specification, antenna development, sex determination, and courtship behavior. Some proteins wit...

[]

0

[ "PANTHER" ]

[ "PTHR23110" ]

[ "Dros_DevTransReg" ]

[ 15619 ]

1

[]

0

[ "8rc6" ]

1

[]

0

[]

0

null

[ "Eukaryota" ]

[ 15619 ]

1

[ "Caenorhabditis elegans", "Drosophila melanogaster" ]

[ 1, 111 ]

2

true

Family

Drosophila Developmental Transcription Regulators

Dros_DevTransReg

3

IPR051096

51,096

BhsA/McbA stress and biofilm-associated protein

BhsA/McbA_stress_biofilm_assoc

Family

8,823

true

false

This family of proteins is involved in the cellular response to stress conditions, particularly in the context of biofilm formation and resistance to copper. Members of this family are implicated in reducing the permeability of the outer membrane to copper ions, which may be a protective mechanism against copper toxici...

[]

0

[ "PANTHER" ]

[ "PTHR34156" ]

[ "BhsA/McbA_stress_biofilm_assoc" ]

[ 8823 ]

1

[]

0

[ "2jna", "2m2j", "4evu" ]

3

[]

0

[]

0

null

[ "Bacteria", "Opisthokonta", "ecological metagenomes" ]

[ 8810, 7, 6 ]

3

[ "Escherichia coli (strain K12)" ]

[ 8 ]

1

true

Family

BhsA/McbA stress and biofilm-associated protein

BhsA/McbA_stress_biofilm_assoc

5

IPR051097

51,097

Synaptobrevin-like vesicular transport protein

Synaptobrevin-like_transport

Family

10,955

true

false

This family of proteins is involved in the intracellular transport processes, specifically in the targeting and fusion of transport vesicles with their respective target membranes. Members of this family play a crucial role in various vesicle-mediated transport pathways, including the transport of proteins from the ear...

[]

0

[ "PANTHER" ]

[ "PTHR21136" ]

[ "Synaptobrevin-like_transport" ]

[ 10955 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-DDI-199992", "R-GGA-432720", "R-GGA-432722", "R-GGA-8856825", "R-GGA-8856828", "R-GGA-9020591", "R-HSA-199992", "R-HSA-432720", "R-HSA-432722", "R-HSA-8856825", "R-HSA-8856828", "R-HSA-9020591", "R-RNO-199992", "R-RNO-432720", "R-RNO-432722", "R-RNO-8856825", "R-RNO-8856828", "R...

[ "REACTOME:R-DDI-199992", "REACTOME:R-GGA-432720", "REACTOME:R-GGA-432722", "REACTOME:R-GGA-8856825", "REACTOME:R-GGA-8856828", "REACTOME:R-GGA-9020591", "REACTOME:R-HSA-199992", "REACTOME:R-HSA-432720", "REACTOME:R-HSA-432722", "REACTOME:R-HSA-8856825", "REACTOME:R-HSA-8856828", "REACTOME:R-HS...

18

[ "2dmw", "2vx8", "4afi", "4b93" ]

4

[]

0

[]

0

null

[ "Eukaryota", "Legionellales", "unclassified Klosneuvirinae" ]

[ 10951, 2, 2 ]

3

[ "Arabidopsis thaliana", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 47, 2, 1, 6, 2, 1, 27, 6, 66 ]

9

true

Family

Synaptobrevin-like vesicular transport protein

Synaptobrevin-like_transport

9

IPR051098

51,098

Neuronal Differentiation E-box Binding Transcription Factors

NeuroDiff_E-box_TFs

Family

9,264

true

false

The protein family is comprised of transcription factors involved in the initiation of neuronal differentiation and various developmental processes. Members of the family are characterized by their ability to bind to E-box motifs (5'-CANNTG-3') in the promoter regions of target genes, thereby activating transcription. ...

[]

0

[ "PANTHER" ]

[ "PTHR11793" ]

[ "NeuroDiff_E-box_TFs" ]

[ 9264 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-CEL-525793", "R-DME-525793", "R-DME-8939236", "R-DRE-525793", "R-HSA-525793", "R-HSA-8939236", "R-HSA-9031628", "R-HSA-9764725", "R-HSA-9839394", "R-MMU-525793", "R-MMU-8939236", "R-RNO-525793", "R-RNO-8939236" ]

[ "REACTOME:R-CEL-525793", "REACTOME:R-DME-525793", "REACTOME:R-DME-8939236", "REACTOME:R-DRE-525793", "REACTOME:R-HSA-525793", "REACTOME:R-HSA-8939236", "REACTOME:R-HSA-9031628", "REACTOME:R-HSA-9764725", "REACTOME:R-HSA-9839394", "REACTOME:R-MMU-525793", "REACTOME:R-MMU-8939236", "REACTOME:R-R...

13

[ "2mh0", "2ql2", "2ypa", "2ypb", "3u5v", "6mgn", "6od3", "6od4", "6od5", "7wz6", "8osb" ]

11

[]

0

[]

0

null

[ "Eukaryota", "bird metagenome" ]

[ 9263, 1 ]

2

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 59, 6, 76, 69, 29 ]

6

true

Family

Neuronal Differentiation E-box Binding Transcription Factors

NeuroDiff_E-box_TFs

8

IPR051099

51,099

Anterior Gradient and Thioredoxin Domain

AGR/TXD

Family

7,506

true

false

The AGR family proteins are involved in a variety of cellular processes, including the formation of cement glands, cell migration, differentiation, growth, and adhesion. Some members function as protein-disulfide reductases in the endoplasmic reticulum, promoting disulfide bond formation in client proteins through thio...

[]

0

[ "PANTHER" ]

[ "PTHR15337" ]

[ "AGR/TXD" ]

[ 7506 ]

1

[]

0

[ "1sen", "2ju5", "2k8v", "2lns", "2lnt", "3ph9", "9i3f", "9i3u" ]

8

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Methanobacteriota", "ecological metagenomes" ]

[ 3975, 3385, 67, 79 ]

4

[ "Caenorhabditis elegans", "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 3, 12, 3, 12 ]

5

true

Family

Anterior Gradient and Thioredoxin Domain

AGR/TXD

1

IPR051101

51,101

ZC3H12/N4BP1 Ribonuclease and Regulator

ZC3H12/N4BP1_RNase_Reg

Family

7,673

true

false

The ZC3H12/N4BP1 protein family includes endoribonucleases and regulatory proteins involved in various biological processes such as immune homeostasis, inflammation, glial differentiation, apoptosis, adipogenesis, and angiogenesis. Members of the family function as RNases, regulating mRNA and pre-miRNA levels, thereby ...

[]

0

[ "PANTHER" ]

[ "PTHR12876" ]

[ "ZC3H12/N4BP1_RNase_Reg" ]

[ 7673 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-DRE-9758274", "R-HSA-9758274", "R-HSA-9764302", "R-MMU-9758274", "R-XTR-9758274" ]

[ "REACTOME:R-DRE-9758274", "REACTOME:R-HSA-9758274", "REACTOME:R-HSA-9764302", "REACTOME:R-MMU-9758274", "REACTOME:R-XTR-9758274" ]

5

[ "2n5j", "2n5m", "2n7k", "3v32", "3v33", "3v34", "5h9v", "5h9w", "6q3v", "6sjd", "7ndh", "7ndi", "7ndj", "7ndk", "8t48", "8wzc", "9bgl", "9cs9", "9hts" ]

19

[]

0

[]

0

null

[ "Eukaryota", "Methanobacteriota" ]

[ 7670, 3 ]

2

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 5, 10, 2, 21, 17, 21 ]

6

true

Family

ZC3H12/N4BP1 Ribonuclease and Regulator

ZC3H12/N4BP1_RNase_Reg

8

IPR051103

51,103

Plant secondary metabolite cytochrome P450s

Plant_metabolite_P450s

Family

6,497

true

false

This family of proteins includes enzymes that are part of the cytochrome P450 superfamily, known for their involvement in the metabolism of a wide range of substrates through oxidation reactions. Members of this family play diverse roles in the biosynthesis of plant secondary metabolites, including the conversion of fl...

[]

0

[ "PANTHER" ]

[ "PTHR24298" ]

[ "Plant_metabolite_P450s" ]

[ 6497 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota" ]

[ 3, 6494 ]

2

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 171, 73, 52 ]

3

true

Family

Plant secondary metabolite cytochrome P450s

Plant_metabolite_P450s

3

IPR051104

51,104

FAD-dependent monooxygenase-like

FAD_monoxygenase-like

Family

6,911

true

This family of proteins includes FAD-dependent monooxygenases involved in various biosynthetic pathways, primarily in fungi. These enzymes catalyze key oxidative steps in the production of secondary metabolites with diverse biological activities, including antitumor agents, antifungal compounds, and pigments. They are ...

[]

0

[ "PANTHER" ]

[ "PTHR46720" ]

[ "FAD_monoxygenase" ]

[ 6911 ]

1

[]

0

[ "5evy", "6bz5", "6nes", "6net", "6neu", "6nev", "7lo1", "9h8m", "9h8z" ]

9

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "ecological metagenomes" ]

[ 331, 6576, 4 ]

3

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)" ]

[ 2 ]

1

true

Family

FAD-dependent monooxygenase-like

FAD_monoxygenase-like

9

IPR051105

51,105

WWC/KIBRA Hippo Pathway Regulators

WWC/KIBRA_Hippo_Reg

Family

6,466

true

false

The WWC/KIBRA protein family consists of negative regulators of the Hippo signaling pathway, also known as the Salvador-Warts-Hippo (SWH) pathway. This pathway is crucial for organ size control and tumor suppression, as it restricts cell proliferation and promotes apoptosis through a kinase cascade. Family members, suc...

[]

0

[ "PANTHER" ]

[ "PTHR14791" ]

[ "WWC/KIBRA_Hippo_Reg" ]

[ 6466 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-DME-2028269", "R-HSA-2028269", "R-HSA-9013508", "R-MMU-2028269", "R-XTR-2028269" ]

[ "REACTOME:R-DME-2028269", "REACTOME:R-HSA-2028269", "REACTOME:R-HSA-9013508", "REACTOME:R-MMU-2028269", "REACTOME:R-XTR-2028269" ]

5

[ "6j68", "6j69", "6jjw", "6jjx", "6jjy" ]

5

[]

0

[]

0

null

[ "Eukaryota", "Runella rosea" ]

[ 6465, 1 ]

2

[ "Arabidopsis thaliana", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 20, 6, 5, 10, 3, 13, 10, 16 ]

8

true

Family

WWC/KIBRA Hippo Pathway Regulators

WWC/KIBRA_Hippo_Reg

8

IPR051106

51,106

RNA-binding and splicing regulatory protein

RNA-bind/splicing_reg

Family

4,362

true

false

This family of proteins includes factors involved in the regulation of RNA processing events, particularly pre-mRNA splicing. Members are characterized by their ability to bind RNA and sometimes DNA, often with a preference for single-stranded nucleic acids and specific purine-rich sequences. They play crucial roles in...

[]

0

[ "PANTHER" ]

[ "PTHR48028" ]

[ "RNA-bind/splicing_reg" ]

[ 4362 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-159236", "R-BTA-72163", "R-BTA-72165", "R-BTA-72187", "R-BTA-72203", "R-BTA-73856", "R-GGA-72163", "R-GGA-72165", "R-GGA-72187", "R-GGA-72203", "R-GGA-73856", "R-HSA-159236", "R-HSA-72163", "R-HSA-72165", "R-HSA-72187", "R-HSA-72203", "R-HSA-73856", "R-MMU-159236", "R-MMU-...

[ "REACTOME:R-BTA-159236", "REACTOME:R-BTA-72163", "REACTOME:R-BTA-72165", "REACTOME:R-BTA-72187", "REACTOME:R-BTA-72203", "REACTOME:R-BTA-73856", "REACTOME:R-GGA-72163", "REACTOME:R-GGA-72165", "REACTOME:R-GGA-72187", "REACTOME:R-GGA-72203", "REACTOME:R-GGA-73856", "REACTOME:R-HSA-159236", "R...

35

[ "6cmn", "6xh0", "6xh2" ]

3

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "ecological metagenomes" ]

[ 38, 4321, 3 ]

3

[ "Arabidopsis thaliana", "Danio rerio", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 10, 3, 3, 1, 1, 10, 2, 61 ]

8

true

Family

RNA-binding and splicing regulatory protein

RNA-bind/splicing_reg

1

IPR051107

51,107

Auxin Efflux Carrier

Auxin_Efflux_Carrier

Family

6,929

true

false

The Auxin Efflux Carrier family is involved in the transport and homeostasis of the plant hormone auxin, essential for plant growth and development. Members of this family act as components of the auxin efflux carrier system, mediating the formation of auxin gradients crucial for organogenesis, vein patterning, and roo...

[]

0

[ "PANTHER" ]

[ "PTHR31752" ]

[ "Auxin_Efflux_Carrier" ]

[ 6929 ]

1

[]

0

[ "7qp9", "7qpa", "7qpc", "7wks", "7wkw", "7xxb", "7y9t", "7y9u", "7y9v", "8jh5", "9g0w", "9g0x", "9g0z", "9g10" ]

14

[]

0

[]

0

null

[ "Eukaryota" ]

[ 6929 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 43, 27, 49 ]

3

true

Family

Auxin Efflux Carrier

Auxin_Efflux_Carrier

3

IPR051109

51,109

Membrane-associated multiprotein complex regulator

MAM_complex_regulator

Family

5,054

true

false

This family of proteins is involved in the establishment and maintenance of the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. They form membrane-associated multiprotein complexes that may regulate the delivery and recycling of proteins to their correct membrane domains. Th...

[]

0

[ "PANTHER" ]

[ "PTHR14063" ]

[ "MAM_complex_regulator" ]

[ 5054 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-196780", "R-BTA-199220", "R-BTA-212676", "R-BTA-425397", "R-BTA-5666185", "R-DRE-196780", "R-DRE-199220", "R-DRE-425397", "R-DRE-6803544", "R-DRE-936837", "R-GGA-196780", "R-GGA-199220", "R-GGA-212676", "R-GGA-425397", "R-GGA-6803544", "R-GGA-936837", "R-HSA-196780", "R-HSA-...

[ "REACTOME:R-BTA-196780", "REACTOME:R-BTA-199220", "REACTOME:R-BTA-212676", "REACTOME:R-BTA-425397", "REACTOME:R-BTA-5666185", "REACTOME:R-DRE-196780", "REACTOME:R-DRE-199220", "REACTOME:R-DRE-425397", "REACTOME:R-DRE-6803544", "REACTOME:R-DRE-936837", "REACTOME:R-GGA-196780", "REACTOME:R-GGA-1...

39

[ "1wi2", "1y74", "2dkr", "3lra", "3uit" ]

5

[]

0

[]

0

null

[ "Eukaryota" ]

[ 5054 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 3, 7, 3, 11, 9, 18 ]

6

true

Family

Membrane-associated multiprotein complex regulator

MAM_complex_regulator

3

IPR051110

51,110

Ly-6/neurotoxin-like and GPI-anchored

Ly-6/neurotoxin-like_GPI-ap

Family

4,848

true

false

The Ly-6/neurotoxin-like protein family includes GPI-anchored and secreted proteins that interact with nicotinic and muscarinic acetylcholine receptors (nAChRs and mAChRs), modulating their activity and affecting various physiological processes. Family members are involved in the regulation of T-lymphocyte proliferatio...

[]

0

[ "PANTHER" ]

[ "PTHR16983" ]

[ "Ly-6/neurotoxin-like_GPI-ap" ]

[ 4848 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-163125", "R-HSA-8963889", "R-HSA-8963901", "R-HSA-975634", "R-MMU-163125", "R-MMU-8963889", "R-MMU-8963901", "R-MMU-975634" ]

[ "REACTOME:R-HSA-163125", "REACTOME:R-HSA-8963889", "REACTOME:R-HSA-8963901", "REACTOME:R-HSA-975634", "REACTOME:R-MMU-163125", "REACTOME:R-MMU-8963889", "REACTOME:R-MMU-8963901", "REACTOME:R-MMU-975634" ]

8

[ "2l03", "2n99", "6e7k", "6oau", "6oaz", "6ob0", "6zze", "6zzf" ]

8

[]

0

[]

0

null

[ "Eumetazoa" ]

[ 4848 ]

1

[ "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 14, 20, 31 ]

4

true

Family

Ly-6/neurotoxin-like and GPI-anchored

Ly-6/neurotoxin-like_GPI-ap

8

IPR051111

51,111

Calcium-binding regulatory protein

Ca-binding_regulatory

Family

4,153

true

false

This family of proteins includes calcium-binding proteins that are involved in various cellular processes. Members of this family are characterized by their ability to bind calcium, which suggests a role as potential calcium sensors. Some proteins within this family are implicated in the negative regulation of Golgi-to...

[]

0

[ "PANTHER" ]

[ "PTHR46311" ]

[ "Ca-binding_regulatory" ]

[ 4153 ]

1

[]

0

[ "2lv7", "6psd", "8rx8" ]

3

[]

0

[]

0

null

[ "Bacteria", "Eukaryota" ]

[ 4, 4149 ]

2

[ "Arabidopsis thaliana", "Danio rerio", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 3, 11, 10, 11, 4, 10, 6 ]

7

true

Family

Calcium-binding regulatory protein

Ca-binding_regulatory

8

IPR051112

51,112

Pre-mRNA-splicing factor CWC26

CWC26_splicing_factor

Family

4,678

true

false

The CWC26 family comprises proteins involved in the pre-mRNA splicing process. Members of the CWC26 family are components of the spliceosome, a complex molecular machine that removes introns from a transcribed pre-mRNA segment. Specifically, some family members are implicated in the splicing of U12-type introns as part...

[]

0

[ "PANTHER" ]

[ "PTHR31809" ]

[ "CWC26_splicing_factor" ]

[ 4678 ]

1

[ "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-72163", "R-MMU-72163", "R-RNO-72163" ]

[ "REACTOME:R-HSA-72163", "REACTOME:R-MMU-72163", "REACTOME:R-RNO-72163" ]

3

[ "2mkc", "2my2", "4uqt", "5gm6", "5lqw", "5z56", "5z57", "5z58", "5zwm", "5zwo", "6ff4", "6ff7", "7abi", "7dco", "7dvq", "7qtt", "8ch6", "8i0p", "8i0r" ]

19

[]

0

[]

0

null

[ "Eukaryota", "Nocardioides mesophilus" ]

[ 4677, 1 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 5, 1, 1, 1, 2, 2, 1, 5, 4, 1, 1, 6 ]

12

true

Family

Pre-mRNA-splicing factor CWC26

CWC26_splicing_factor

2

IPR051113

51,113

Integrator complex subunit 6

Integrator_subunit6

Family

4,423

true

false

The Integrator subunit 6 family is involved in the transcription and 3'-box-dependent processing of small nuclear RNAs (snRNA), including U1, U2, U4, U5, and U7. Family members are components of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II's largest subunit. They may also pla...

[]

0

[ "PANTHER" ]

[ "PTHR12957" ]

[ "Integrator_subunit6" ]

[ 4423 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-DDI-6807505", "R-DME-6807505", "R-HSA-6807505", "R-MMU-6807505" ]

[ "REACTOME:R-DDI-6807505", "REACTOME:R-DME-6807505", "REACTOME:R-HSA-6807505", "REACTOME:R-MMU-6807505" ]

4

[ "7bv7", "7cun", "7pks", "7ycx", "8hpp", "8rbx", "8rbz", "8rc4", "8yjb", "9vd9" ]

10

[]

0

[]

0

null

[ "Eukaryota" ]

[ 4423 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 3, 1, 28, 8, 10 ]

6

true

Family

Integrator complex subunit 6

Integrator_subunit6

6

IPR051114

51,114

Mitochondrial RNA Processing CCM1

Mito_RNA_Proc_CCM1

Family

7,361

true

false

The CCM1 family comprises RNA-binding proteins that play a crucial role in mitochondrial gene expression. Members of this family are involved in the specific removal of group I introns from mitochondrial encoded transcripts, which is essential for the correct processing of these RNAs. They also contribute to the stabil...

[]

0

[ "PANTHER" ]

[ "PTHR47934" ]

[ "Mito_RNA_Proc_CCM1" ]

[ 7361 ]

1

[]

0

[ "9hny" ]

1

[]

0

[]

0

null

[ "Bacteria", "Eukaryota" ]

[ 91, 7270 ]

2

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Zea mays" ]

[ 64, 23, 1, 42 ]

4

true

Family

Mitochondrial RNA Processing CCM1

Mito_RNA_Proc_CCM1

8

IPR051115

51,115

Lysosomal-associated transmembrane transporter

LAPTM_transporter

Family

4,144

true

false

This family of proteins is involved in intracellular transport processes, particularly associated with lysosomal and endosomal membrane compartments. Members of this family may function in the translocation of nucleosides, nucleoside derivatives, and other essential amino acids across intracellular membranes. Some prot...

[]

0

[ "PANTHER" ]

[ "PTHR12479" ]

[ "LAPTM_transporter" ]

[ 4144 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Eukaryota" ]

[ 4144 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 13, 4, 3, 12, 25, 12 ]

6

true

Family

Lysosomal-associated transmembrane transporter

LAPTM_transporter

3

IPR051116

51,116

Cell Surface Receptors and Adhesion Molecules

Surface_Rcpt/Adhesion_Mol

Family

4,157

true

false

The protein family includes cell surface receptors and adhesion molecules with diverse roles in cell-cell interactions, signaling, and inflammatory responses. Members of the family mediate heterotypic and homotypic cell-cell contacts, often through interactions with specific ligands such as CD6 or laminin. They are inv...

[]

0

[ "PANTHER" ]

[ "PTHR11973" ]

[ "Surface_Rcpt/Adhesion_Mol" ]

[ 4157 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-HSA-373760", "R-HSA-445989", "R-HSA-879415", "R-HSA-8980692", "R-HSA-9013026", "R-HSA-9013106", "R-HSA-9013149", "R-HSA-9013404", "R-HSA-9013405", "R-HSA-9013408", "R-HSA-9013423", "R-HSA-9035034", "R-HSA-933542", "R-MMU-445989", "R-MMU-879415", "R-MMU-8980692", "R-MMU-9013026", ...

[ "REACTOME:R-HSA-373760", "REACTOME:R-HSA-445989", "REACTOME:R-HSA-879415", "REACTOME:R-HSA-8980692", "REACTOME:R-HSA-9013026", "REACTOME:R-HSA-9013106", "REACTOME:R-HSA-9013149", "REACTOME:R-HSA-9013404", "REACTOME:R-HSA-9013405", "REACTOME:R-HSA-9013408", "REACTOME:R-HSA-9013423", "REACTOME:R...

35

[ "2e5e", "2ens", "2l7u", "2le9", "2m1k", "2mjw", "2mov", "2pet", "2pf6", "3cjj", "4im8", "4lp4", "4lp5", "4of5", "4ofv", "4oi7", "4oi8", "4p2y", "4ybh", "5a2f", "6lyn", "6xq1", "6xq3", "6xq5", "6xq6", "6xq7", "6xq8", "6xq9", "7lml", "7lmw", "8i9m" ]

31

[]

0

[]

0

null

[ "Eukaryota" ]

[ 4157 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 15, 59, 19, 21 ]

4

true

Family

Cell Surface Receptors and Adhesion Molecules

Surface_Rcpt/Adhesion_Mol

3

IPR051117

51,117

T cell receptor gamma variable/constant region

TRG_var/const_region

Family

3,304

true

false

The T cell receptor gamma (TRG) family includes proteins involved in antigen recognition and the initiation of innate-like immune responses. TRG proteins are expressed on the surface of T cells, particularly gamma-delta T cells, which recognize self and foreign non-peptide antigens at epithelial boundaries. Antigen bin...

[]

0

[ "PANTHER" ]

[ "PTHR19256" ]

[ "TRG_var/const_region" ]

[ 3304 ]

1

[]

0

[ "1hxm", "1ypz", "3omz", "4lfh", "4lhu", "4mng", "4mnh", "4ndm", "6d7g", "6mwr", "7k0x", "7k0z", "7l15", "7lli", "7llj", "7ryl", "7rym", "7ryn", "7ryo", "8dfw", "8jbv", "8jc0", "8jcb", "8wxe", "8wy0", "8wyi", "8yc0", "8za6", "8zd4", "9cq4", "9cq7", "9cq8"...

41

[]

0

[]

0

null

[ "Candidatus Epulonipiscium fishelsonii", "Gnathostomata" ]

[ 2, 3302 ]

2

[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 23, 22, 10 ]

3

true

Family

T cell receptor gamma variable/constant region

TRG_var/const_region

6

IPR051118

51,118

Lateral signaling target protein 2

LST-2

Family

3,057

true

false

This family of proteins acts as negative regulators of epidermal growth factor receptor (EGFR) signaling. Members of this family are involved in promoting the degradation of EGFR within endosomes. This regulatory activity is crucial for controlling the signaling pathways that influence cell proliferation and differenti...

[]

0

[ "PANTHER" ]

[ "PTHR46465" ]

[ "LST-2" ]

[ 3057 ]

1

[]

0

[ "9f43", "9f45" ]

2

[]

0

[]

0

null

[ "Eukaryota", "Streptococcus parasanguinis" ]

[ 3056, 1 ]

2

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 11, 2, 3, 3, 3, 4 ]

6

true

Family

Lateral signaling target protein 2

LST-2

6

IPR051119

51,119

Nematode serpentine receptor-like

Nematode_SR-like

Family

1,210

true

false

This family of proteins includes serpentine receptors, which are likely to function as G protein-coupled receptors (GPCRs). These receptors typically have a seven-transmembrane domain structure and are involved in signal transduction processes. They are known to play crucial roles in sensing environmental signals and i...

[]

0

[ "PANTHER" ]

[ "PTHR31627" ]

[ "Nematode_SR-like" ]

[ 1210 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Chromadorea" ]

[ 1210 ]

1

[ "Caenorhabditis elegans" ]

[ 34 ]

1

true

Family

Nematode serpentine receptor-like

Nematode_SR-like

6

IPR051120

51,120

ABC Transporter, Amino Acid and LPS Transport

ABC_AA/LPS_Transport

Family

79,625

true

false

The protein family is involved in the transport of specific substrates across cellular membranes using ATP hydrolysis for energy. Members of the family function as components of ABC transporter complexes, which are critical for the translocation of substances such as branched-chain amino acids and lipopolysaccharides (...

[]

0

[ "PANTHER" ]

[ "PTHR45772" ]

[ "ABC_AA/LPS_Transport" ]

[ 79625 ]

1

[]

0

[ "1g6h", "1g9x", "1gaj", "4p31", "4p32", "4p33", "4qc2", "4wbs", "5l75", "5x5y", "6b89", "6b8b", "6hs3", "6mbn", "6mgf", "6mhu", "6mhz", "6mi7", "6mi8", "6mit", "6mjp", "6s8g", "6s8h", "6s8n", "7efo", "8frl", "8frm", "8frn", "8fro", "8frp", "8ufg", "8ufh"...

32

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Siphoviridae sp. ctwQg18", "Sym plasmid", "unclassified sequences" ]

[ 1634, 76148, 119, 1, 1, 1722 ]

6

[ "Escherichia coli (strain K12)" ]

[ 2 ]

1

true

Family

ABC Transporter, Amino Acid and LPS Transport

ABC_AA/LPS_Transport

1

IPR051121

51,121

Fumarylacetoacetate hydrolase

FAH

Family

30,863

true

The FAH family encompasses enzymes with diverse functions, including hydrolase activity and participation in various metabolic pathways. Members of the family are involved in the degradation of specific substrates such as ureidoglycolate, fumarylacetoacetate, and pentoses like D-xylose and D-arabinonate. These enzymes ...

[]

0

[ "PANTHER" ]

[ "PTHR42796" ]

[ "FAH" ]

[ 30863 ]

1

[]

0

[ "2q18", "2q19", "2q1a", "2q1c", "2q1d", "3bqb", "3r6o", "4dbf", "4dbh", "6v77", "8gsr", "8gst" ]

12

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Sym plasmid", "unclassified sequences" ]

[ 922, 27687, 1740, 1, 513 ]

5

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 10, 2, 5, 1, 5 ]

5

true

Family

Fumarylacetoacetate hydrolase

FAH

6

IPR051122

51,122

SDR DHRS6-like

SDR_DHRS6-like

Family

38,335

false

This family of proteins includes enzymes that are part of the short-chain dehydrogenases/reductases (SDR) superfamily. Members of this family are involved in various metabolic processes, including the biosynthesis of secondary metabolites, fatty acids, and siderophores, as well as the detoxification of harmful compound...

[]

0

[ "PANTHER" ]

[ "PTHR43477" ]

[ "" ]

[ 38335 ]

1

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "1.1.1", "R-DRE-77111", "R-HSA-77111", "R-MMU-77111", "R-RNO-77111" ]

[ "EC:1.1.1", "REACTOME:R-DRE-77111", "REACTOME:R-HSA-77111", "REACTOME:R-MMU-77111", "REACTOME:R-RNO-77111" ]

5

[ "1nxq", "1zjy", "1zjz", "1zk0", "1zk1", "1zk2", "1zk3", "1zk4", "2ag5", "2cfc", "2dtd", "2dte", "2dtx", "2zk7", "3d7l", "3uce", "3ucf", "4e4y", "4fgs", "4i5g", "4yqz", "5jc8", "5tt0", "6h07", "6h1m", "6k8v", "6k8w", "6nkh", "6nkk", "6nkm", "6y0s", "6y10"...

42

[ "PUB00058305" ]

[ "16380372" ]

[ "Characterization of human DHRS6, an orphan short chain dehydrogenase/reductase enzyme: a novel, cytosolic type 2 R-beta-hydroxybutyrate dehydrogenase." ]

[ 2006 ]

1

[ "IPR002347" ]

[ "IPR057571" ]

1

0

[ "Archaea", "Bacteria", "Eukaryota", "metagenomes" ]

[ 190, 33503, 4181, 461 ]

4

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus" ]

[ 3, 8, 2, 1, 4 ]

5

true

Family

SDR DHRS6-like

SDR_DHRS6-like

7

IPR051124

51,124

Binding-Protein-Dependent Phosphate Transport Permease

Phosphate_Transport_Permease

Family

18,285

true

false

The phosphate transport system permease family is characterized by its role in the binding-protein-dependent transport system for phosphate. Members of this family are predominantly involved in the translocation of phosphate across the cellular membrane. They are typically part of larger ABC transporter complexes, whic...

[]

0

[ "PANTHER" ]

[ "PTHR30425" ]

[ "Phosphate_Transport_Permease" ]

[ 18285 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 629, 17268, 10, 378 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Binding-Protein-Dependent Phosphate Transport Permease

Phosphate_Transport_Permease

2

IPR051125

51,125

ABC-4 integral membrane protein family, HrtB subfamily

ABC-4/HrtB_transporter

Family

15,756

true

false

The ABC-4 integral membrane protein family, specifically the HrtB subfamily, is involved in the transport of hemin across the bacterial cell membrane. Members of the HrtB subfamily are part of the ABC transporter complex hrt, which is responsible for hemin import. These permease proteins facilitate the translocation of...

[]

0

[ "PANTHER" ]

[ "PTHR43738" ]

[ "ABC-4/HrtB_transporter" ]

[ 15756 ]

1

[]

0

[ "7w78", "7w79", "7w7a", "7w7b", "7w7c", "7w7d" ]

6

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 233, 15335, 14, 174 ]

4

[]

0

true

Family

ABC-4 integral membrane protein family, HrtB subfamily

ABC-4/HrtB_transporter

5

IPR051126

51,126

Thiosulfate sulfurtransferase domain-containing protein

Thiosulfate_sulfurtransferase

Family

13,043

true

false

This family of proteins is involved in sulfur metabolism, specifically in the transfer of sulfur from thiosulfate to other molecules. Members of this family typically contain two rhodanese domains, although only the C-terminal domain harbors the catalytic cysteine residue essential for activity. These proteins may func...

[]

0

[ "PANTHER" ]

[ "PTHR43855" ]

[ "Thiosulfate_sulfurtransferase" ]

[ 13043 ]

1

[ "EC", "METACYC", "METACYC" ]

[ "2.8.1.1", "PWY-5350", "PWY-7927" ]

[ "EC:2.8.1.1", "METACYC:PWY-5350", "METACYC:PWY-7927" ]

3

[ "1e0c", "1h4k", "1h4m", "1uar", "1yt8", "2eg3", "2eg4", "3aax", "3aay", "3hwi", "3hzu", "3p3a", "6h98", "6h99", "6h9a", "6ktv", "6ktw", "6ktx", "6ktz", "6ku1", "6ku2", "6kvw", "6kvy", "6kvz", "6kw0", "8k55", "8k57" ]

27

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 1160, 11424, 159, 300 ]

4

[]

0

true

Family

Thiosulfate sulfurtransferase domain-containing protein

Thiosulfate_sulfurtransferase

8

IPR051130

51,130

Mitochondrial structure and function regulator

Mito_struct-func_regulator

Family

14,491

true

false

This family of proteins includes members that are involved in various cellular processes, primarily associated with mitochondrial function and structure. Some proteins within this family appear to play a crucial role in maintaining mitochondrial cristae formation and overall mitochondrial health. They may act in a kina...

[]

0

[ "PANTHER" ]

[ "PTHR43173" ]

[ "Mito_struct-func_regulator" ]

[ 14491 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Mimiviridae", "metagenomes" ]

[ 1338, 13116, 10, 27 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 47, 1, 9, 3, 5, 4, 5, 24, 10, 1, 2, 57 ]

12

true

Family

Mitochondrial structure and function regulator

Mito_struct-func_regulator

6

IPR051131

51,131

NEK Ser/Thr protein kinase family, NIMA subfamily

NEK_Ser/Thr_kinase_NIMA

Family

15,161

true

false

The NEK Ser/Thr protein kinase family, part of the NIMA subfamily, is involved in various cellular processes including cell cycle regulation, DNA damage response, and cellular structure organization. Members of this family play crucial roles in centrosome separation, spindle formation, and chromosome condensation durin...

[]

0

[ "PANTHER" ]

[ "PTHR44899" ]

[ "NEK_Ser/Thr_kinase_NIMA" ]

[ 15161 ]

1

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "2.7.11.1", "R-DDI-179409", "R-HSA-179409", "R-HSA-2565942", "R-HSA-380259", "R-HSA-380270", "R-HSA-380284", "R-HSA-380320", "R-HSA-5620912", "R-HSA-8854518", "R-HSA-9861718", "R-MMU-179409", "R-MMU-2565942", "R-MMU-380259", "R-MMU-380270", "R-MMU-380284", "R-MMU-380320", "R-MMU-56...

[ "EC:2.7.11.1", "REACTOME:R-DDI-179409", "REACTOME:R-HSA-179409", "REACTOME:R-HSA-2565942", "REACTOME:R-HSA-380259", "REACTOME:R-HSA-380270", "REACTOME:R-HSA-380284", "REACTOME:R-HSA-380320", "REACTOME:R-HSA-5620912", "REACTOME:R-HSA-8854518", "REACTOME:R-HSA-9861718", "REACTOME:R-MMU-179409", ...

20

[ "2jav", "2w5a", "2w5b", "2w5h", "2wqo", "2xk3", "2xk4", "2xk6", "2xk7", "2xk8", "2xkc", "2xkd", "2xke", "2xkf", "2xnm", "2xnn", "2xno", "2xnp", "4a4x", "4afe", "4apc", "4b9d", "5m51", "5m53", "5m55", "5m57", "6sgd", "6sgh", "6sgi", "6sgk", "6sk9", "6tm5"...

32

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 25, 15130, 6 ]

3

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 109, 1, 31, 27, 1, 29, 1 ]

8

true

Family

NEK Ser/Thr protein kinase family, NIMA subfamily

NEK_Ser/Thr_kinase_NIMA

2

IPR051132

51,132

3'-5' Exonuclease domain-containing protein

3-5_Exonuclease_domain

Family

11,108

true

false

This family of proteins includes exonucleases with 3'-5' activity, acting on single-stranded and duplex DNA or RNA substrates. They play crucial roles in DNA replication, repair, and stability, as well as in mitochondrial metabolism and translation. Some members are involved in the RNA-induced silencing complex (RISC),...

[]

0

[ "PANTHER" ]

[ "PTHR13620" ]

[ "3-5_Exonuclease_domain" ]

[ 11108 ]

1

[ "EC" ]

[ "3.1.11.-" ]

[ "EC:3.1.11.-" ]

1

[ "1vk0", "2e6l", "2e6m", "2fbt", "2fbv", "2fbx", "2fby", "2fc0", "2q3s", "5v5f", "6k17", "6k18", "6k19", "6k1a", "6k1b", "6k1c", "6k1d", "6k1e" ]

18

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Viruses", "metagenomes" ]

[ 586, 10458, 42, 22 ]

4

[ "Arabidopsis thaliana", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 55, 2, 4, 5, 4, 1, 42, 2, 31 ]

9

true

Family

3'-5' Exonuclease domain-containing protein

3-5_Exonuclease_domain

3

IPR051133

51,133

Adapter and Engulfment Domain-Containing Protein

Adapter_Engulfment-Domain

Family

11,398

true

false

This family of proteins includes various adapter proteins that play roles in cellular processes such as endocytosis, nitric oxide synthesis regulation, and phagocytosis of apoptotic cells. Members of this family are involved in the formation of protein complexes that are essential for specific functions at the cellular...

[]

0

[ "PANTHER" ]

[ "PTHR11232" ]

[ "Adapter_Engulfment-Domain" ]

[ 11398 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-196791", "R-HSA-8856825", "R-HSA-8856828", "R-HSA-8964026", "R-HSA-8964038", "R-HSA-9758890", "R-MMU-8856825", "R-MMU-8856828", "R-MMU-8964026", "R-MMU-8964038", "R-MMU-9758890", "R-RNO-196791", "R-RNO-8856825", "R-RNO-8856828", "R-RNO-8964026", "R-RNO-8964038", "R-RNO-9758890...

[ "REACTOME:R-HSA-196791", "REACTOME:R-HSA-8856825", "REACTOME:R-HSA-8856828", "REACTOME:R-HSA-8964026", "REACTOME:R-HSA-8964038", "REACTOME:R-HSA-9758890", "REACTOME:R-MMU-8856825", "REACTOME:R-MMU-8856828", "REACTOME:R-MMU-8964026", "REACTOME:R-MMU-8964038", "REACTOME:R-MMU-9758890", "REACTOME...

17

[ "3so6", "6itu" ]

2

[]

0

[]

0

null

[ "Eukaryota" ]

[ 11398 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 3, 54, 10, 18, 14, 29 ]

6

true

Family

Adapter and Engulfment Domain-Containing Protein

Adapter_Engulfment-Domain

6

IPR051134

51,134

Protein Phosphatase PPP

PPP_phosphatase

Family

11,172

true

false

The PPP phosphatase family is involved in a variety of cellular processes including apoptosis, differentiation, DNA damage response, cell survival, regulation of ion channels, circadian rhythms, and phototransduction. Members of the family dephosphorylate a wide range of proteins such as kinases, nuclear receptors, SMA...

[]

0

[ "PANTHER" ]

[ "PTHR45668" ]

[ "PPP_phosphatase" ]

[ 11172 ]

1

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "3.1.3.16", "R-CEL-2514859", "R-CEL-5675221", "R-HSA-2514859", "R-HSA-5675221", "R-HSA-5693565", "R-HSA-8939211", "R-MMU-2514859", "R-MMU-5675221", "R-MMU-5693565", "R-MMU-8939211", "R-RNO-2514859", "R-RNO-5675221", "R-RNO-5693565", "R-RNO-8939211", "R-SCE-5693565", "R-SPO-5693565" ]

[ "EC:3.1.3.16", "REACTOME:R-CEL-2514859", "REACTOME:R-CEL-5675221", "REACTOME:R-HSA-2514859", "REACTOME:R-HSA-5675221", "REACTOME:R-HSA-5693565", "REACTOME:R-HSA-8939211", "REACTOME:R-MMU-2514859", "REACTOME:R-MMU-5675221", "REACTOME:R-MMU-5693565", "REACTOME:R-MMU-8939211", "REACTOME:R-RNO-251...

17

[ "1s95", "1wao", "3h60", "3h61", "3h62", "3h63", "3h64", "3h66", "3h67", "3h68", "3h69", "3icf", "4ja7", "4ja9", "4zvz", "4zx2", "5hpe", "5jjt", "5ui1", "5wg8", "7obe", "7zr5", "7zr6", "8gae", "8gft", "8jfw", "8jfy" ]

27

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Bodo saltans virus", "Eukaryota", "marine sediment metagenome" ]

[ 27, 4, 1, 11139, 1 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 20, 3, 26, 3, 24, 5, 1, 5, 14, 1, 1, 20 ]

12

true

Family

Protein Phosphatase PPP

PPP_phosphatase

1

IPR051135

51,135

Gal/GlcNAc/GalNAc Sulfotransferase

Gal/GlcNAc/GalNAc_ST

Family

8,880

true

false

The Gal/GlcNAc/GalNAc sulfotransferase family is involved in the post-translational modification of glycosaminoglycans and glycoproteins. Members of this family utilize 3'-phospho-5'-adenylyl sulfate (PAPS) as a sulfonate donor to catalyze the transfer of sulfate groups to various carbohydrate residues. This sulfation ...

[]

0

[ "PANTHER" ]

[ "PTHR10704" ]

[ "Gal/GlcNAc/GalNAc_ST" ]

[ 8880 ]

1

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "2.8.2", "R-DRE-2022854", "R-HSA-2022854", "R-HSA-2022870", "R-HSA-3595172", "R-HSA-3656225", "R-HSA-913709", "R-MMU-2022854", "R-MMU-2022870", "R-MMU-913709", "R-RNO-2022854", "R-RNO-2022870" ]

[ "EC:2.8.2", "REACTOME:R-DRE-2022854", "REACTOME:R-HSA-2022854", "REACTOME:R-HSA-2022870", "REACTOME:R-HSA-3595172", "REACTOME:R-HSA-3656225", "REACTOME:R-HSA-913709", "REACTOME:R-MMU-2022854", "REACTOME:R-MMU-2022870", "REACTOME:R-MMU-913709", "REACTOME:R-RNO-2022854", "REACTOME:R-RNO-2022870"...

12

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 6, 1194, 7647, 7, 26 ]

5

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 10, 3, 15, 11, 15 ]

5

true

Family

Gal/GlcNAc/GalNAc Sulfotransferase

Gal/GlcNAc/GalNAc_ST

2

IPR051136

51,136

Intracellular Lectin and Glycoprotein Transporter

Intracellular_Lectin-GPT

Family

10,022

true

false

This family of proteins includes intracellular lectins that play roles in the early secretory pathway. They are involved in the recognition and transport of glycoproteins, particularly those with specific glycan structures such as high mannose-type glycans, N-acetyl-D-galactosamine, and potentially O-linked glycans. Th...

[]

0

[ "PANTHER" ]

[ "PTHR12223" ]

[ "Intracellular_Lectin-GPT" ]

[ 10022 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-204005", "R-BTA-5694530", "R-CFA-204005", "R-CFA-5694530", "R-HSA-204005", "R-HSA-5694530", "R-HSA-8980692", "R-HSA-9013106", "R-HSA-9013404", "R-HSA-9013405", "R-HSA-9013408", "R-HSA-9013423", "R-HSA-948021", "R-MMU-204005", "R-MMU-5694530", "R-MMU-8980692", "R-MMU-9013106", ...

[ "REACTOME:R-BTA-204005", "REACTOME:R-BTA-5694530", "REACTOME:R-CFA-204005", "REACTOME:R-CFA-5694530", "REACTOME:R-HSA-204005", "REACTOME:R-HSA-5694530", "REACTOME:R-HSA-8980692", "REACTOME:R-HSA-9013106", "REACTOME:R-HSA-9013404", "REACTOME:R-HSA-9013405", "REACTOME:R-HSA-9013408", "REACTOME:R...

29

[ "1gv9", "1r1z", "2a6v", "2a6w", "2a6x", "2a6y", "2a6z", "2a70", "2a71", "2duo", "2dup", "2duq", "2dur", "2e6v", "3a4u", "3lcp", "3wht", "3whu", "3wnx", "4gkx", "4gky", "4ygb", "4ygc", "4ygd", "4yge", "5zbt", "8jp4", "8jp5", "8jp6", "8jp7", "8jp8", "8jp9"...

33

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Thermococcaceae", "hydrothermal vent metagenome" ]

[ 498, 9520, 2, 2 ]

4

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strai...

[ 2, 7, 2, 26, 12, 2, 18, 3, 2 ]

9

true

Family

Intracellular Lectin and Glycoprotein Transporter

Intracellular_Lectin-GPT

1

IPR051137

51,137

Serine/threonine-protein phosphatase 4 regulatory subunit 3-like

PP4R3-like

Family

9,184

true

This family includes Serine/threonine-protein phosphatase 4 regulatory subunit 3 (PP4R3) from Saccharomyces cerevisiae, a core regulatory subunit of the histone H2A phosphatase complex, which dephosphorylates H2AS128ph (gamma-H2A) that has been displaced from sites of DNA lesions in the double-stranded DNA break repair...

[ "GO:0019888" ]

[ "protein phosphatase regulator activity" ]

[ "molecular_function" ]

1

[ "PANTHER" ]

[ "PTHR23318" ]

[ "PP4_regulatory_subunit_3" ]

[ 9184 ]

1

[]

0

[ "4wsf", "6r8i" ]

2

[ "PUB00078845" ]

[ "16299494" ]

[ "A phosphatase complex that dephosphorylates gammaH2AX regulates DNA damage checkpoint recovery." ]

[ 2006 ]

1

[]

0

null

[ "Eukaryota" ]

[ 9184 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 17, 2, 3, 3, 10, 11, 1, 9, 18, 1, 1, 49 ]

12

true

Family

Serine/threonine-protein phosphatase 4 regulatory subunit 3-like

PP4R3-like

3

IPR051138

51,138

PIM Serine/Threonine Kinase

PIM_Ser/Thr_kinase

Family

9,221

true

false

The PIM kinase family comprises serine/threonine kinases involved in cell survival, proliferation, and tumorigenesis. Members regulate various cellular processes, including MYC transcriptional activity, cell cycle progression, cap-dependent protein translation, and apoptosis inhibition. They phosphorylate and stabilize...

[]

0

[ "PANTHER" ]

[ "PTHR22984" ]

[ "PIM_Ser/Thr_kinase" ]

[ 9221 ]

1

[ "EC", "REACTOME", "REACTOME", "REACTOME" ]

[ "2.7.11.1", "R-HSA-6785807", "R-HSA-9702518", "R-HSA-9703465" ]

[ "EC:2.7.11.1", "REACTOME:R-HSA-6785807", "REACTOME:R-HSA-9702518", "REACTOME:R-HSA-9703465" ]

4

[ "1xqz", "1xr1", "1xws", "1yhs", "1yi3", "1yi4", "1ywv", "1yxs", "1yxt", "1yxu", "1yxv", "1yxx", "2bik", "2bil", "2bzh", "2bzi", "2bzj", "2bzk", "2c3i", "2iwi", "2j2i", "2o3p", "2o63", "2o64", "2o65", "2obj", "2oi4", "2xix", "2xiy", "2xiz", "2xj0", "2xj1"...

192

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Nucleocytoviricota", "viral metagenome" ]

[ 11, 9185, 22, 3 ]

4

[ "Caenorhabditis elegans", "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 5, 1079, 7, 12, 9 ]

5

true

Family

PIM Serine/Threonine Kinase

PIM_Ser/Thr_kinase

4