interpro_id string | interpro_numeric_id int64 | name string | short_name string | entry_type string | protein_count int64 | is_llm bool | is_llm_reviewed bool | abstract string | go_ids list | go_terms list | go_categories list | go_count int64 | member_databases list | member_accessions list | member_names list | member_protein_counts list | member_count int64 | external_databases list | external_accessions list | external_xrefs list | external_xref_count int64 | pdb_ids list | structure_count int64 | publication_ids list | pubmed_ids list | publication_titles list | publication_years list | publication_count int64 | parent_ids list | child_ids list | parent_count int64 | child_count int64 | tree_depth float64 | taxonomy_names list | taxonomy_protein_counts list | taxonomy_count int64 | key_species_names list | key_species_protein_counts list | key_species_count int64 | in_entry_list bool | entry_list_type string | entry_list_name string | names_dat_name string | short_names_dat_name string | split_bucket int64 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
IPR051258 | 51,258 | Diverse Substrate Transporter | Diverse_Substrate_Transporter | Family | 33,617 | true | false | This family of proteins includes transporters involved in the uptake and export of various substances across cellular membranes. Members of this family are characterized by their ability to transport a range of compounds, such as biotin and aromatic amino acids, including phenylalanine, tyrosine, and tryptophan. Some p... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR42920"
] | [
"Diverse_Substrate_Transporter"
] | [
33617
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
356,
31010,
1793,
458
] | 4 | [
"Escherichia coli (strain K12)",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
3,
8,
14
] | 3 | true | Family | Diverse Substrate Transporter | Diverse Substrate Transporter | Diverse_Substrate_Transporter | 2 |
IPR051259 | 51,259 | Ribosomal RNA Methyltransferase | rRNA_Methyltransferase | Family | 36,383 | true | false | The RNA methyltransferase family is characterized by its members' ability to catalyze the methylation of ribose in various ribosomal RNA (rRNA) molecules, utilizing S-adenosyl-L-methionine (SAM) as the methyl donor. These enzymes are responsible for the post-transcriptional modification of rRNA, which is a conserved pr... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR43191"
] | [
"rRNA_Methyltransferase"
] | [
36383
] | 1 | [
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC"... | [
"2.1.1.-",
"PWY-1061",
"PWY-2083",
"PWY-3542",
"PWY-4021",
"PWY-4161",
"PWY-4202",
"PWY-5059",
"PWY-5105",
"PWY-5301",
"PWY-5305",
"PWY-5479",
"PWY-5665",
"PWY-5729",
"PWY-5748",
"PWY-5765",
"PWY-5773",
"PWY-5846",
"PWY-5883",
"PWY-5975",
"PWY-5987",
"PWY-601",
"PWY-6045"... | [
"EC:2.1.1.-",
"METACYC:PWY-1061",
"METACYC:PWY-2083",
"METACYC:PWY-3542",
"METACYC:PWY-4021",
"METACYC:PWY-4161",
"METACYC:PWY-4202",
"METACYC:PWY-5059",
"METACYC:PWY-5105",
"METACYC:PWY-5301",
"METACYC:PWY-5305",
"METACYC:PWY-5479",
"METACYC:PWY-5665",
"METACYC:PWY-5729",
"METACYC:PWY-5... | 147 | [
"1ipa",
"1x7o",
"1x7p",
"2i6d",
"3gyq",
"3nk6",
"3nk7",
"4x3l",
"4x3m",
"5kzk",
"5l0z",
"6yxx",
"6yxy",
"7am2",
"7aoi",
"7oi6",
"7qiu",
"9h1k",
"9hcc",
"9hcd",
"9hce",
"9muj",
"9muk"
] | 23 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
32031,
3675,
6,
671
] | 4 | [
"Arabidopsis thaliana",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
10,
4,
2,
2,
1,
5,
2,
15
] | 8 | true | Family | Ribosomal RNA Methyltransferase | Ribosomal RNA Methyltransferase | rRNA_Methyltransferase | 8 |
IPR051260 | 51,260 | Diverse substrate monooxygenases | Diverse_substr_monoxygenases | Family | 38,485 | true | false | This family of proteins includes monooxygenases that catalyze diverse oxidative reactions, often involving the cleavage of carbon-sulfur bonds without breaking carbon-carbon bonds. Members are involved in various biological processes, such as the degradation of sulfur-containing compounds like dibenzothiophene-sulfone,... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR30011"
] | [
"Diverse_substr_monoxygenases"
] | [
38485
] | 1 | [] | [] | [] | 0 | [
"1tvl",
"1yw1",
"2b81",
"3b9n",
"3b9o",
"3sdo",
"5dqp",
"5tlc",
"5w48",
"5w4y",
"5w4z",
"5xkc",
"5xkd",
"6ak1",
"6ask",
"6asl",
"6lr1",
"7cza",
"7e36"
] | 19 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
253,
34380,
3638,
214
] | 4 | [
"Arabidopsis thaliana",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)"
] | [
1,
2
] | 2 | true | Family | Diverse substrate monooxygenases | Diverse substrate monooxygenases | Diverse_substr_monoxygenases | 2 |
IPR051261 | 51,261 | NOD-like receptor | NLR | Family | 37,791 | true | true | The NOD-like receptor (NLR) family is involved in the innate immune response, acting as pattern recognition receptors (PRRs) that detect pathogen-associated molecular patterns (PAMPs) and danger danger associated molecular patterns (DAMPs) [ ]. Members of the family participate in various signalling pathways, including... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR24106"
] | [
"NLR"
] | [
37791
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-168638",
"R-BTA-450302",
"R-BTA-450321",
"R-BTA-5689896",
"R-HSA-168638",
"R-HSA-168928",
"R-HSA-3270619",
"R-HSA-445989",
"R-HSA-450302",
"R-HSA-450321",
"R-HSA-5689896",
"R-HSA-9020702",
"R-HSA-936440",
"R-HSA-9705671",
"R-HSA-9758274",
"R-MMU-168638",
"R-MMU-450302",
"R-M... | [
"REACTOME:R-BTA-168638",
"REACTOME:R-BTA-450302",
"REACTOME:R-BTA-450321",
"REACTOME:R-BTA-5689896",
"REACTOME:R-HSA-168638",
"REACTOME:R-HSA-168928",
"REACTOME:R-HSA-3270619",
"REACTOME:R-HSA-445989",
"REACTOME:R-HSA-450302",
"REACTOME:R-HSA-450321",
"REACTOME:R-HSA-5689896",
"REACTOME:R-HSA-... | 23 | [
"3un9",
"5irl",
"5irm",
"5irn"
] | 4 | [
"PUB00160068"
] | [
"25071785"
] | [
"NOD-Like Receptors: Master Regulators of Inflammation and Cancer."
] | [
2014
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota"
] | [
16,
37775
] | 2 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
977,
15,
19,
17
] | 4 | true | Family | NOD-like receptor | NOD-like receptor | NLR | 3 |
IPR051262 | 51,262 | SMP-30/CGR1 Lactonase | SMP-30/CGR1_Lactonase | Family | 16,939 | true | false | The SMP-30/CGR1 family proteins are characterized by their lactonase activity, which plays a role in maintaining membrane homeostasis, particularly in cells with compromised membrane integrity. Some family members are known to contribute to bacitracin resistance and may act on various lactones, although their natural s... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR47572"
] | [
"SMP-30/CGR1_Lactonase"
] | [
16939
] | 1 | [
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC"... | [
"3.1.1.-",
"PWY-1921",
"PWY-5835",
"PWY-6190",
"PWY-6308",
"PWY-6322",
"PWY-6339",
"PWY-6415",
"PWY-6558",
"PWY-6848",
"PWY-7002",
"PWY-7352",
"PWY-7367",
"PWY-7521",
"PWY-7599",
"PWY-7660",
"PWY-7712",
"PWY-7713",
"PWY-7730",
"PWY-7769",
"PWY-7982",
"PWY-8058",
"PWY-8143... | [
"EC:3.1.1.-",
"METACYC:PWY-1921",
"METACYC:PWY-5835",
"METACYC:PWY-6190",
"METACYC:PWY-6308",
"METACYC:PWY-6322",
"METACYC:PWY-6339",
"METACYC:PWY-6415",
"METACYC:PWY-6558",
"METACYC:PWY-6848",
"METACYC:PWY-7002",
"METACYC:PWY-7352",
"METACYC:PWY-7367",
"METACYC:PWY-7521",
"METACYC:PWY-7... | 28 | [
"1e1a",
"1pjx",
"2dg0",
"2dg1",
"2dso",
"2gvu",
"2gvv",
"2gvw",
"2gvx",
"2iao",
"2iap",
"2iaq",
"2iar",
"2ias",
"2iat",
"2iau",
"2iav",
"2iaw",
"2iax",
"3byc",
"3dr2",
"3e5z",
"3hlh",
"3hli",
"3i1c",
"3kgg",
"3li3",
"3li4",
"3li5",
"3o4p",
"3u0s",
"4o5s"... | 45 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
61,
15044,
1480,
354
] | 4 | [] | [] | 0 | true | Family | SMP-30/CGR1 Lactonase | SMP-30/CGR1 Lactonase | SMP-30/CGR1_Lactonase | 9 |
IPR051263 | 51,263 | Cytochrome c-type biogenesis | C-type_cytochrome_biogenesis | Family | 20,580 | true | false | This family of proteins is involved in the biogenesis of c-type cytochromes, which are heme-containing proteins essential for electron transport and energy generation in the respiratory chain. Members of this family may function as subunits of a heme lyase complex, which is responsible for the attachment of heme to apo... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR47870"
] | [
"C-type_cytochrome_biogenesis"
] | [
20580
] | 1 | [] | [] | [] | 0 | [
"2e2e",
"2hl7",
"2kw0",
"3bee"
] | 4 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Methanobacteriota",
"unclassified sequences"
] | [
20262,
24,
4,
290
] | 4 | [
"Escherichia coli (strain K12)"
] | [
3
] | 1 | true | Family | Cytochrome c-type biogenesis | Cytochrome c-type biogenesis | C-type_cytochrome_biogenesis | 3 |
IPR051264 | 51,264 | FAD-binding Oxidoreductase/Transferase Type 4 | FAD-oxidored/transferase_4 | Family | 20,305 | true | false | The FAD-binding oxidoreductase/transferase type 4 family is involved in the oxidation of various D-2-hydroxyacids, primarily catalyzing the conversion of D-2-hydroxyglutarate (D-2-HG) to alpha-ketoglutarate. Members of the family also oxidize other substrates such as D-malate and D-lactate, albeit with varying degrees ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR43716"
] | [
"FAD-oxidored/transferase_4"
] | [
20305
] | 1 | [
"EC",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"1.1.99.39",
"PWY-5283",
"R-BTA-880009",
"R-DRE-880009",
"R-HSA-880009",
"R-MMU-880009",
"R-RNO-880009",
"R-SCE-880009",
"R-SPO-880009"
] | [
"EC:1.1.99.39",
"METACYC:PWY-5283",
"REACTOME:R-BTA-880009",
"REACTOME:R-DRE-880009",
"REACTOME:R-HSA-880009",
"REACTOME:R-MMU-880009",
"REACTOME:R-RNO-880009",
"REACTOME:R-SCE-880009",
"REACTOME:R-SPO-880009"
] | 9 | [
"1f0x",
"3pm9",
"6lpn",
"6lpp",
"6lpq",
"6lpt",
"6lpu",
"6lpx"
] | 8 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
14830,
5300,
175
] | 3 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
4,
1,
4,
3,
1,
14,
5,
1,
3,
5,
2,
1,
16
] | 13 | true | Family | FAD-binding Oxidoreductase/Transferase Type 4 | FAD-binding Oxidoreductase/Transferase Type 4 | FAD-oxidored/transferase_4 | 8 |
IPR051265 | 51,265 | HIBADH-related NP60 subfamily | HIBADH-related_NP60_sf | Family | 22,580 | true | false | The HIBADH-related NP60 subfamily is involved in various biological processes, including chromatin modification, gene expression regulation, and oxidative stress tolerance. Members of this family act as nucleosome-destabilizing factors during transcriptional activation, recognizing and binding histone H3 and DNA withou... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR43580"
] | [
"HIBADH-related_NP60_sf"
] | [
22580
] | 1 | [] | [] | [] | 0 | [
"1i36",
"2uyy",
"3doj",
"3l6d",
"3pdu",
"3pef",
"3qsg",
"3zgy",
"3zhb",
"4d3d",
"4d3f",
"4d3s",
"4gbj",
"4oqy",
"4oqz",
"5a9r",
"5a9s",
"5a9t",
"5fwn",
"5g6r",
"5g6s",
"5ocm",
"5ojl",
"6eod",
"6eoh",
"6eoi",
"6grl",
"6h7p",
"6jit",
"6jiz",
"6skx",
"6sle"... | 91 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
208,
14190,
8064,
118
] | 4 | [
"Arabidopsis thaliana",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
10,
9,
3,
3,
2,
2,
4,
4,
19
] | 9 | true | Family | HIBADH-related NP60 subfamily | HIBADH-related NP60 subfamily | HIBADH-related_NP60_sf | 4 |
IPR051266 | 51,266 | Calcium-activated chloride channel regulator | CLCR | Family | 20,754 | true | false | The CLCR family includes proteins that are involved in mediating calcium-activated chloride conductance. Members of this family may play a role in various physiological processes such as goblet cell metaplasia, mucus hypersecretion, cystic fibrosis, airway hyperresponsiveness (AHR), and the regulation of tissue inflamm... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR10579"
] | [
"CLCR"
] | [
20754
] | 1 | [
"REACTOME",
"REACTOME"
] | [
"R-HSA-2672351",
"R-MMU-2672351"
] | [
"REACTOME:R-HSA-2672351",
"REACTOME:R-MMU-2672351"
] | 2 | [
"6pyo",
"6pyx"
] | 2 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
258,
9134,
11214,
16,
132
] | 5 | [
"Arabidopsis thaliana",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
41,
5,
6,
14,
2,
87,
15,
96
] | 8 | true | Family | Calcium-activated chloride channel regulator | Calcium-activated chloride channel regulator | CLCR | 8 |
IPR051267 | 51,267 | STEAP family metalloreductases | STEAP_metalloreductase | Family | 20,794 | true | false | The STEAP family proteins are integral membrane metalloreductases that function as NADPH-dependent ferric-chelate reductases. They facilitate the reduction of Fe(3+) to Fe(2+) across cellular membranes, using NADPH to transfer electrons through FAD and heme groups to the iron chelate. Some family members also reduce Cu... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR14239"
] | [
"STEAP_metalloreductase"
] | [
20794
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-6803204",
"R-HSA-9013148",
"R-HSA-9013405",
"R-HSA-9013406",
"R-HSA-9013409",
"R-HSA-9035034",
"R-HSA-917977",
"R-MMU-6803204",
"R-MMU-9013405",
"R-MMU-9013406",
"R-MMU-9035034",
"R-MMU-917977",
"R-RNO-6803204",
"R-RNO-9013405",
"R-RNO-9013406",
"R-RNO-9035034",
"R-RNO-917977"... | [
"REACTOME:R-HSA-6803204",
"REACTOME:R-HSA-9013148",
"REACTOME:R-HSA-9013405",
"REACTOME:R-HSA-9013406",
"REACTOME:R-HSA-9013409",
"REACTOME:R-HSA-9035034",
"REACTOME:R-HSA-917977",
"REACTOME:R-MMU-6803204",
"REACTOME:R-MMU-9013405",
"REACTOME:R-MMU-9013406",
"REACTOME:R-MMU-9035034",
"REACTOME... | 17 | [
"1jax",
"1jay",
"2raf",
"2vns",
"2vq3",
"2yjz",
"3dtt",
"4huj",
"5n2i",
"6hcy",
"6hd1",
"6y9b",
"7tai",
"8ucd",
"9pgw",
"9pgx",
"9pgy"
] | 17 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
803,
15052,
4764,
175
] | 4 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
8,
21,
14,
16
] | 4 | true | Family | STEAP family metalloreductases | STEAP family metalloreductases | STEAP_metalloreductase | 3 |
IPR051268 | 51,268 | Type I restriction enzyme R subunit | Type-I_R_enzyme_R_subunit | Family | 16,292 | true | false | This family of proteins includes the restriction (R) subunits of type I restriction enzymes. These enzymes are complex molecular machines that recognize specific DNA sequences, which are often asymmetric and contain non-methylated sites. Upon DNA binding, they translocate along the DNA in an ATP-dependent manner until ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR30195"
] | [
"Type-I_R_enzyme_R_subunit"
] | [
16292
] | 1 | [
"EC"
] | [
"3.1.21.3"
] | [
"EC:3.1.21.3"
] | 1 | [
"2w00",
"4be7",
"4beb",
"4bec",
"4xjx",
"6h2j",
"7bst",
"7bto",
"7btp",
"7btq",
"7btr"
] | 11 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Caudoviricetes",
"Eukaryota",
"unclassified sequences"
] | [
443,
15463,
2,
40,
344
] | 5 | [] | [] | 0 | true | Family | Type I restriction enzyme R subunit | Type I restriction enzyme R subunit | Type-I_R_enzyme_R_subunit | 1 |
IPR051269 | 51,269 | Iron-sulfur cluster electron transport | Fe-S_cluster_ET | Family | 17,272 | true | false | This family of proteins includes electron transporters that play a crucial role in various metabolic processes. Members of this family are primarily involved in transferring electrons through iron-sulfur clusters, acting as redox partners for different cytochrome P450 systems. They are essential components in the biosy... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR36923"
] | [
"Fe-S_cluster_ET"
] | [
17272
] | 1 | [] | [] | [] | 0 | [
"1dwl",
"1f2g",
"1fxd",
"1rof",
"1siz",
"1sj1",
"1vjw",
"2z8q",
"3pni",
"4dhv",
"4id8",
"4ov1",
"8amp"
] | 13 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Geodia barretti",
"Sym plasmid",
"metagenomes",
"uncultured Caudovirales phage"
] | [
630,
16359,
1,
1,
280,
1
] | 6 | [] | [] | 0 | true | Family | Iron-sulfur cluster electron transport | Iron-sulfur cluster electron transport | Fe-S_cluster_ET | 9 |
IPR051271 | 51,271 | Two-component system transcriptional regulators | 2C-system_Tx_regulators | Family | 15,100 | true | false | The protein family is composed of transcriptional regulatory proteins that are part of two-component regulatory systems, which are typically involved in sensing environmental stimuli and regulating gene expression in response. Members of the family function as response regulators that, upon phosphorylation, bind to DNA... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR45526"
] | [
"2C-system_Tx_regulators"
] | [
15100
] | 1 | [] | [] | [] | 0 | [
"5lwk",
"5lwl"
] | 2 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
20,
15009,
9,
62
] | 4 | [
"Escherichia coli (strain K12)"
] | [
2
] | 1 | true | Family | Two-component system transcriptional regulators | Two-component system transcriptional regulators | 2C-system_Tx_regulators | 6 |
IPR051272 | 51,272 | RIO-type Ser/Thr kinase | RIO-type_Ser/Thr_kinase | Family | 11,916 | true | false | This family of proteins includes serine/threonine kinases predominantly involved in ribosomal biogenesis, particularly in the maturation of the 40S ribosomal subunit. They are implicated in the processing of pre-rRNA into mature 18S rRNA, and their catalytic activity is suggested to regulate their dynamic association w... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR45723"
] | [
"RIO-type_Ser/Thr_kinase"
] | [
11916
] | 1 | [
"EC",
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"2.7.11.1",
"3.6.1.-",
"PWY-5757",
"PWY-6147",
"PWY-6383",
"PWY-6797",
"PWY-7206",
"PWY-7419",
"PWY-7539",
"PWY-7719",
"PWY-7821",
"PWY-8289",
"R-BTA-6791226",
"R-HSA-6791226",
"R-MMU-6791226"
] | [
"EC:2.7.11.1",
"EC:3.6.1.-",
"METACYC:PWY-5757",
"METACYC:PWY-6147",
"METACYC:PWY-6383",
"METACYC:PWY-6797",
"METACYC:PWY-7206",
"METACYC:PWY-7419",
"METACYC:PWY-7539",
"METACYC:PWY-7719",
"METACYC:PWY-7821",
"METACYC:PWY-8289",
"REACTOME:R-BTA-6791226",
"REACTOME:R-HSA-6791226",
"REACTO... | 15 | [
"1zp9",
"1ztf",
"1zth",
"3re4",
"4jin",
"4otp",
"6g5i",
"6zv6",
"6zxd",
"6zxe",
"6zxf",
"6zxg",
"6zxh",
"8zdb",
"8zdc",
"8zdd"
] | 16 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
883,
3791,
7155,
87
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
13,
2,
2,
2,
9,
12,
1,
4,
5,
1,
1,
14
] | 12 | true | Family | RIO-type Ser/Thr kinase | RIO-type Ser/Thr kinase | RIO-type_Ser/Thr_kinase | 2 |
IPR051274 | 51,274 | 3'-5' Exoribonuclease | 3-5_Exoribonuclease | Family | 12,312 | true | false | This family of proteins includes 3'-5' exoribonucleases involved in various RNA processing and degradation pathways. Members of this family play roles in the decay of histone mRNAs post-replication, suggesting a regulatory function in histone protein expression. They are capable of degrading RNA substrates with differe... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR23044"
] | [
"3-5_Exoribonuclease"
] | [
12312
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-6791226",
"R-MMU-6791226",
"R-RNO-6791226"
] | [
"REACTOME:R-HSA-6791226",
"REACTOME:R-MMU-6791226",
"REACTOME:R-RNO-6791226"
] | 3 | [
"1w0h",
"1zbh",
"1zbu",
"2xri",
"3cg7",
"3cm5",
"3cm6",
"4l8r",
"4qoz",
"5dk5",
"7k05",
"7k06",
"7k07",
"7lpy",
"7lpz",
"7lq0",
"7n8v",
"7n8w"
] | 18 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Viruses",
"metagenomes"
] | [
4582,
7671,
17,
42
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Schizosaccharomyces pombe (stra... | [
5,
5,
2,
1,
16,
11,
1,
15,
11,
1,
23
] | 11 | true | Family | 3'-5' Exoribonuclease | 3'-5' Exoribonuclease | 3-5_Exoribonuclease | 6 |
IPR051276 | 51,276 | Saccharopine dehydrogenase-like oxidoreductase | Saccharopine_DH-like_oxidrdct | Family | 10,756 | true | false | This family of proteins is involved in the biosynthesis of complex lipids, specifically in the reduction of the double bond between C-4 and C-5 during the production of phthiocerol dimycocerosates (DIM A) and glycosylated phenolphthiocerol dimycocerosates (PGL). These compounds are significant components of the cell wa... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR12286"
] | [
"Saccharopine_DH-like_oxidrdct"
] | [
10756
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-CEL-114608",
"R-HSA-114608",
"R-MMU-114608",
"R-RNO-114608"
] | [
"REACTOME:R-CEL-114608",
"REACTOME:R-HSA-114608",
"REACTOME:R-MMU-114608",
"REACTOME:R-RNO-114608"
] | 4 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Halobacteria",
"unclassified sequences"
] | [
4005,
6614,
90,
47
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
6,
4,
5,
2,
2,
5,
1,
3,
4,
4
] | 10 | true | Family | Saccharopine dehydrogenase-like oxidoreductase | Saccharopine dehydrogenase-like oxidoreductase | Saccharopine_DH-like_oxidrdct | 2 |
IPR051277 | 51,277 | SEZ6/CSMD/C4BPB Neuronal & Immune Regulators | SEZ6_CSMD_C4BPB_Regulators | Family | 18,957 | true | false | The SEZ6/CSMD protein family includes members that are involved in various neuronal functions. SEZ6 family proteins are implicated in cell-cell recognition, neuronal membrane signaling, and the development of dendritic arbors, contributing to the establishment of excitatory synaptic connectivity. They may also play a r... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR45656"
] | [
"SEZ6_CSMD_C4BPB_Regulators"
] | [
18957
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-6798695",
"R-HSA-8877330",
"R-HSA-977606",
"R-MMU-977606",
"R-RNO-6798695",
"R-RNO-977606"
] | [
"REACTOME:R-HSA-6798695",
"REACTOME:R-HSA-8877330",
"REACTOME:R-HSA-977606",
"REACTOME:R-MMU-977606",
"REACTOME:R-RNO-6798695",
"REACTOME:R-RNO-977606"
] | 6 | [
"1e5g",
"1gkg",
"1gkn",
"1h03",
"1h04",
"1h2p",
"1h2q",
"1ly2",
"1ntj",
"1ntl",
"1nwv",
"1ojv",
"1ojw",
"1ojy",
"1ok1",
"1ok2",
"1ok3",
"1ok9",
"1ppq",
"1uot",
"1upn",
"1vvc",
"1vvd",
"1vve",
"2a55",
"2c8i",
"2gsx",
"2mcz",
"2qzd",
"2qzh",
"2rlp",
"2rlq"... | 54 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Viruses"
] | [
18849,
108
] | 2 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
51,
7,
58,
35,
43
] | 5 | true | Family | SEZ6/CSMD/C4BPB Neuronal & Immune Regulators | SEZ6/CSMD/C4BPB Neuronal & Immune Regulators | SEZ6_CSMD_C4BPB_Regulators | 2 |
IPR051278 | 51,278 | CoM-S-S-CoB heterodisulfide reductase | HdrB/HdrD_reductase | Family | 3,065 | true | true | The HdrB/HdrD family is involved in the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B), playing a crucial role in methanogenesis [ , ]. The family includes subunits of heterodisulfide reductase complexes that transfer electrons from various donors such as hydrog... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR42947"
] | [
"HdrB/HdrD_reductase"
] | [
3065
] | 1 | [
"EC"
] | [
"1.8.98"
] | [
"EC:1.8.98"
] | 1 | [
"5odc",
"5odh",
"5odi",
"5odq",
"5odr",
"7bkb",
"7bkc",
"7bkd",
"7bke",
"8rvu",
"8rvv",
"8rvy",
"8rwn"
] | 13 | [
"PUB00088716",
"PUB00163182"
] | [
"19968794",
"11034998"
] | [
"Methanogenesis by Methanosarcina acetivorans involves two structurally and functionally distinct classes of heterodisulfide reductase.",
"Characterization of the intramolecular electron transfer pathway from 2-hydroxyphenazine to the heterodisulfide reductase from Methanosarcina thermophila."
] | [
2010,
2001
] | 2 | [] | [
"IPR017678"
] | 0 | 1 | 0 | [
"Archaea",
"Bacteria",
"Metazoa",
"unclassified sequences"
] | [
699,
2062,
7,
297
] | 4 | [] | [] | 0 | true | Family | CoM-S-S-CoB heterodisulfide reductase | CoM-S-S-CoB heterodisulfide reductase | HdrB/HdrD_reductase | 7 |
IPR051279 | 51,279 | Protein Phosphatase 1 Regulatory and Actin Interaction Protein | PP1-Reg/Actin-Interact_Protein | Family | 8,230 | true | false | This family of proteins includes regulatory subunits that modulate the activity of protein phosphatase 1 (PP1) complexes, acting as inhibitors. They are involved in the control of various cellular processes by regulating the dephosphorylation of target proteins. Additionally, this family encompasses proteins that inter... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR24112"
] | [
"PP1-Reg/Actin-Interact_Protein"
] | [
8230
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-DDI-983231",
"R-HSA-983231",
"R-MMU-983231"
] | [
"REACTOME:R-DDI-983231",
"REACTOME:R-HSA-983231",
"REACTOME:R-MMU-983231"
] | 3 | [
"4k17"
] | 1 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Pseudomonadati"
] | [
8214,
16
] | 2 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
4,
38,
13,
13,
9,
17
] | 6 | true | Family | Protein Phosphatase 1 Regulatory and Actin Interaction Protein | Protein Phosphatase 1 Regulatory and Actin Interaction Protein | PP1-Reg/Actin-Interact_Protein | 1 |
IPR051280 | 51,280 | Voltage-gated chloride channel/antiporter | Cl-channel/antiporter | Family | 10,160 | true | false | This family of proteins includes both voltage-gated chloride channels and proton-coupled anion transporters. The channels mediate the transport of chloride ions across the membrane, which is essential for various cellular processes such as regulation of cell volume, membrane potential stabilization, and signal transduc... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR11689"
] | [
"Cl-channel/antiporter"
] | [
10160
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-2672351",
"R-DDI-2672351",
"R-HSA-2672351",
"R-HSA-6802952",
"R-MMU-2672351",
"R-RNO-2672351"
] | [
"REACTOME:R-BTA-2672351",
"REACTOME:R-DDI-2672351",
"REACTOME:R-HSA-2672351",
"REACTOME:R-HSA-6802952",
"REACTOME:R-MMU-2672351",
"REACTOME:R-RNO-2672351"
] | 6 | [
"7bxu",
"7cq5",
"7cq6",
"7cq7",
"7jm6",
"7jm7",
"7xa9",
"8hvt",
"8iab",
"8iad",
"8jpj",
"8jpo",
"8jpr",
"9g6c",
"9g6d",
"9g6e"
] | 16 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota"
] | [
2,
10158
] | 2 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
26,
1,
4,
1,
17,
14,
31,
7,
60
] | 9 | true | Family | Voltage-gated chloride channel/antiporter | Voltage-gated chloride channel/antiporter | Cl-channel/antiporter | 7 |
IPR051281 | 51,281 | Dual-specificity lipid and protein phosphatase | Dual-spec_lipid-protein_phosph | Family | 8,969 | true | false | This family of proteins includes dual-specificity phosphatases with roles in dephosphorylating proteins phosphorylated on tyrosine, serine, and threonine residues. They also function as lipid phosphatases, targeting the D3 position of the inositol ring in various phosphatidylinositols, with a preference for phosphatidy... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR12305"
] | [
"Dual-spec_lipid-protein_phosph"
] | [
8969
] | 1 | [
"EC",
"EC",
"EC",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
... | [
"3.1.3",
"3.1.3.48",
"3.1.3.67",
"PWY-6368",
"R-CEL-1660499",
"R-CEL-1855204",
"R-CEL-199418",
"R-CEL-202424",
"R-CEL-5689880",
"R-CEL-5689896",
"R-CEL-8948747",
"R-CEL-8948751",
"R-CFA-1660499",
"R-CFA-1855204",
"R-CFA-199418",
"R-CFA-202424",
"R-CFA-5689880",
"R-CFA-5689896",
"... | [
"EC:3.1.3",
"EC:3.1.3.48",
"EC:3.1.3.67",
"METACYC:PWY-6368",
"REACTOME:R-CEL-1660499",
"REACTOME:R-CEL-1855204",
"REACTOME:R-CEL-199418",
"REACTOME:R-CEL-202424",
"REACTOME:R-CEL-5689880",
"REACTOME:R-CEL-5689896",
"REACTOME:R-CEL-8948747",
"REACTOME:R-CEL-8948751",
"REACTOME:R-CFA-1660499"... | 66 | [
"1d5r",
"3awe",
"3awf",
"3awg",
"3n0a",
"3v0d",
"3v0e",
"3v0f",
"3v0g",
"3v0h",
"3v0i",
"3v0j",
"5bug",
"5bzx",
"5bzz",
"7jtx",
"7juk",
"7jul",
"7jvx",
"9c49"
] | 20 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
8969
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
13,
1,
13,
6,
34,
17,
1,
4,
7,
1,
1,
5
] | 12 | true | Family | Dual-specificity lipid and protein phosphatase | Dual-specificity lipid and protein phosphatase | Dual-spec_lipid-protein_phosph | 8 |
IPR051282 | 51,282 | Arf-GAP with GTPase, ANK repeat and PH domain-containing protein | Arf-GAP_GTPase_ANK_PH | Family | 8,136 | true | false | This family of proteins includes GTPase-activating proteins (GAPs) for the ADP ribosylation factor family, which are involved in various cellular processes such as the regulation of the adapter protein-dependent trafficking in the endosomal-lysosomal system and the prevention of neuronal apoptosis. Some members may enh... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR45819"
] | [
"Arf-GAP_GTPase_ANK_PH"
] | [
8136
] | 1 | [
"REACTOME"
] | [
"R-HSA-373752"
] | [
"REACTOME:R-HSA-373752"
] | 1 | [
"2bmj",
"2iwr",
"2rlo",
"3ihw",
"7eb6"
] | 5 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"marine metagenome"
] | [
8135,
1
] | 2 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
4,
23,
1,
41,
14,
25
] | 6 | true | Family | Arf-GAP with GTPase, ANK repeat and PH domain-containing protein | Arf-GAP with GTPase, ANK repeat and PH domain-containing protein | Arf-GAP_GTPase_ANK_PH | 5 |
IPR051283 | 51,283 | Secondary metabolite acyltransferase | Sec_Metabolite_Acyltrans | Family | 10,455 | false | false | The acyltransferase family described here is involved in the biosynthesis of various secondary metabolites, including indole alkaloids, dimeric xanthones, meroterpenoids, cyclopeptides, and ergot alkaloids [ , , ]. These enzymes catalyse the transfer of acyl groups, such as acetyl or other acyl-CoA derivatives, to spec... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR31896"
] | [
""
] | [
10455
] | 1 | [
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC"... | [
"2.3.1.-",
"PWY-3602",
"PWY-361",
"PWY-4801",
"PWY-4922",
"PWY-5048",
"PWY-5139",
"PWY-5268",
"PWY-5284",
"PWY-5292",
"PWY-5307",
"PWY-5313",
"PWY-5317",
"PWY-5318",
"PWY-5353",
"PWY-5400",
"PWY-5473",
"PWY-5475",
"PWY-5477",
"PWY-5660",
"PWY-5679",
"PWY-5710",
"PWY-5794"... | [
"EC:2.3.1.-",
"METACYC:PWY-3602",
"METACYC:PWY-361",
"METACYC:PWY-4801",
"METACYC:PWY-4922",
"METACYC:PWY-5048",
"METACYC:PWY-5139",
"METACYC:PWY-5268",
"METACYC:PWY-5284",
"METACYC:PWY-5292",
"METACYC:PWY-5307",
"METACYC:PWY-5313",
"METACYC:PWY-5317",
"METACYC:PWY-5318",
"METACYC:PWY-53... | 219 | [
"2rkt",
"2rkv",
"2zba",
"3b2s",
"3b30",
"6wao",
"6wcs",
"6zbs",
"8h8i",
"8hbt"
] | 10 | [
"PUB00154530",
"PUB00154531",
"PUB00154532",
"PUB00154533"
] | [
"25571861",
"28529508",
"30996871",
"31760159"
] | [
"Elucidation of the concise biosynthetic pathway of the communesin indole alkaloids.",
"The Biosynthetic Gene Cluster for Andrastin A in <i>Penicillium roqueforti</i>.",
"Structure revision of cryptosporioptides and determination of the genetic basis for dimeric xanthone biosynthesis in fungi.",
"PBS3 and EPS... | [
2015,
2017,
2019,
2019
] | 4 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota"
] | [
4,
10451
] | 2 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Zea mays"
] | [
65,
32,
1,
34
] | 4 | true | Family | Secondary metabolite acyltransferase | Secondary metabolite acyltransferase | Sec_Metabolite_Acyltrans | 2 |
IPR051284 | 51,284 | Zinc finger MYM-type/QRICH1 | ZnF_MYMT-QRICH1 | Family | 7,711 | true | false | The Zinc finger MYM-type/QRICH1 protein family is involved in various cellular processes, including transcriptional regulation, cell morphology, cytoskeletal organization, and the integrated stress response (ISR). Members of the family function as transcriptional regulators, with some acting as mediators of the ISR by ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR45736"
] | [
"ZnF_MYMT-QRICH1"
] | [
7711
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-1839117",
"R-HSA-5655302",
"R-HSA-9703465",
"R-HSA-9764725",
"R-MMU-9764725"
] | [
"REACTOME:R-HSA-1839117",
"REACTOME:R-HSA-5655302",
"REACTOME:R-HSA-9703465",
"REACTOME:R-HSA-9764725",
"REACTOME:R-MMU-9764725"
] | 5 | [
"2das",
"9hjt",
"9hju"
] | 3 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Metazoa"
] | [
7711
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
35,
9,
29,
29,
30
] | 5 | true | Family | Zinc finger MYM-type/QRICH1 | Zinc finger MYM-type/QRICH1 | ZnF_MYMT-QRICH1 | 5 |
IPR051285 | 51,285 | NADH-dependent Oxidoreductase Modular Protein | NADH_oxidoreductase_modular | Family | 3,490 | true | false | This family of proteins is involved in electron transfer processes, functioning as oxidoreductases. They are capable of reducing molecular oxygen to water, utilizing NADH as an electron donor. These proteins are modular, containing multiple redox cofactors, which allows them to perform activities that typically require... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR32145"
] | [
"NADH_oxidoreductase_modular"
] | [
3490
] | 1 | [] | [] | [] | 0 | [
"2fz5",
"2klb",
"3fni",
"3hly",
"4fek",
"6h0c",
"6h0d"
] | 7 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Methanobacteriati",
"metagenomes"
] | [
3154,
297,
3,
36
] | 4 | [] | [] | 0 | true | Family | NADH-dependent Oxidoreductase Modular Protein | NADH-dependent Oxidoreductase Modular Protein | NADH_oxidoreductase_modular | 3 |
IPR051286 | 51,286 | Janus Kinase (JAK) | JAK | Family | 7,131 | true | false | The JAK family of non-receptor tyrosine kinases is pivotal in signal transduction for various cellular processes including growth, development, differentiation, and immune response. Members of the family associate with cytokine receptors, phosphorylating them upon ligand binding, which creates docking sites for STAT pr... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR45807"
] | [
"JAK"
] | [
7131
] | 1 | [
"EC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
... | [
"2.7.10.2",
"R-DME-1169408",
"R-DME-1266695",
"R-DME-1433557",
"R-DME-209209",
"R-DME-209228",
"R-DME-210688",
"R-DME-5673000",
"R-DME-6785807",
"R-DME-69231",
"R-DME-8985947",
"R-DME-9006335",
"R-DME-9020558",
"R-DME-9027276",
"R-DME-9027284",
"R-DME-9674555",
"R-DME-9705462",
"R-... | [
"EC:2.7.10.2",
"REACTOME:R-DME-1169408",
"REACTOME:R-DME-1266695",
"REACTOME:R-DME-1433557",
"REACTOME:R-DME-209209",
"REACTOME:R-DME-209228",
"REACTOME:R-DME-210688",
"REACTOME:R-DME-5673000",
"REACTOME:R-DME-6785807",
"REACTOME:R-DME-69231",
"REACTOME:R-DME-8985947",
"REACTOME:R-DME-9006335"... | 176 | [
"1yvj",
"2b7a",
"2w1i",
"2xa4",
"3e62",
"3e63",
"3e64",
"3eyg",
"3eyh",
"3fup",
"3io7",
"3iok",
"3jy9",
"3kck",
"3krr",
"3lpb",
"3lxk",
"3lxl",
"3lxn",
"3lxp",
"3nyx",
"3nz0",
"3pjc",
"3q32",
"3rvg",
"3tjc",
"3tjd",
"3ugc",
"3zc6",
"3zep",
"3zmm",
"3zon"... | 304 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"bird metagenome"
] | [
9,
7119,
3
] | 3 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
13,
4,
54,
20,
16
] | 5 | true | Family | Janus Kinase (JAK) | Janus Kinase (JAK) | JAK | 1 |
IPR051287 | 51,287 | T cell receptor variable region | TCR_variable_region | Family | 8,314 | true | false | The T cell receptor (TCR) variable region family is involved in antigen recognition and is essential for the immune response. TCRs are present on the surface of T lymphocytes and recognize peptide-major histocompatibility (MH) complexes displayed by antigen presenting cells (APCs). The interaction between TCRs and pMH ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR19367"
] | [
"TCR_variable_region"
] | [
8314
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-198933",
"R-HSA-202424",
"R-HSA-202427",
"R-HSA-202430",
"R-HSA-202433",
"R-HSA-389948"
] | [
"REACTOME:R-HSA-198933",
"REACTOME:R-HSA-202424",
"REACTOME:R-HSA-202427",
"REACTOME:R-HSA-202430",
"REACTOME:R-HSA-202433",
"REACTOME:R-HSA-389948"
] | 6 | [
"1ac6",
"1fo0",
"1fyt",
"1g6r",
"1i9e",
"1j8h",
"1lp9",
"1mwa",
"1nam",
"1nfd",
"1tcr",
"1tvd",
"1zgl",
"2ak4",
"2ckb",
"2e7l",
"2icw",
"2j8u",
"2jcc",
"2oi9",
"2ol3",
"2pxy",
"2uwe",
"2z31",
"2z35",
"3c5z",
"3c60",
"3e2h",
"3e3q",
"3kxf",
"3rev",
"3rgv"... | 124 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bilateria",
"Escherichia coli"
] | [
8313,
1
] | 2 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
28,
74,
98
] | 4 | true | Family | T cell receptor variable region | T cell receptor variable region | TCR_variable_region | 9 |
IPR051288 | 51,288 | Serum paraoxonase/arylesterase | Serum_paraoxonase/arylesterase | Family | 5,731 | true | false | The paraoxonase family proteins are involved in the hydrolysis of a variety of substrates, including organophosphate insecticide metabolites, lactones, and aromatic carboxylic acid esters. Members of the family exhibit a broad spectrum of enzymatic activities, such as protecting low density lipoproteins (LDL) from oxid... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR11799"
] | [
"Serum_paraoxonase/arylesterase"
] | [
5731
] | 1 | [
"EC",
"EC",
"EC",
"METACYC",
"METACYC",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"3.1.1.2",
"3.1.1.81",
"3.1.8.1",
"PWY-5489",
"PWY-5490",
"PWY-8065",
"R-BTA-2142688",
"R-CEL-2142688",
"R-CEL-9754706",
"R-HSA-2142688",
"R-HSA-9754706",
"R-MMU-2142688",
"R-MMU-9754706",
"R-RNO-2142688",
"R-RNO-9754706"
] | [
"EC:3.1.1.2",
"EC:3.1.1.81",
"EC:3.1.8.1",
"METACYC:PWY-5489",
"METACYC:PWY-5490",
"METACYC:PWY-8065",
"REACTOME:R-BTA-2142688",
"REACTOME:R-CEL-2142688",
"REACTOME:R-CEL-9754706",
"REACTOME:R-HSA-2142688",
"REACTOME:R-HSA-9754706",
"REACTOME:R-MMU-2142688",
"REACTOME:R-MMU-9754706",
"REAC... | 15 | [
"1v04",
"3sre",
"3srg",
"4hho",
"4hhq",
"4q1u",
"6g82",
"6gmu",
"6h0a",
"9r0q"
] | 10 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"ecological metagenomes"
] | [
474,
5226,
31
] | 3 | [
"Caenorhabditis elegans",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus"
] | [
5,
4,
23,
9,
1,
15
] | 6 | true | Family | Serum paraoxonase/arylesterase | Serum paraoxonase/arylesterase | Serum_paraoxonase/arylesterase | 8 |
IPR051289 | 51,289 | LAGLIDADG Homing Endonuclease | LAGLIDADG_Endonuclease | Family | 4,935 | true | false | This family of proteins includes mitochondrial and nuclear DNA endonucleases that are primarily involved in intron homing, a process where introns or inteins are inserted into specific sites within genes. These enzymes recognize specific DNA sequences and introduce double-stranded breaks, facilitating the spread of the... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR36181"
] | [
"LAGLIDADG_Endonuclease"
] | [
4935
] | 1 | [] | [] | [] | 0 | [
"1mow",
"1p8k",
"2ab5",
"2ex5",
"2qoj",
"3e54",
"3eh8",
"3fd2",
"3mx9",
"3mxa",
"3qqy",
"3r7p",
"3uvf",
"4efj",
"4lox",
"4lq0",
"4yhx",
"4yis",
"4yit",
"4z1x",
"4z1z",
"4z20",
"5e5o",
"5e5p",
"5e5s",
"5e63",
"5e67",
"5esp",
"5gkk",
"5t2h",
"5t2n",
"5t2o"... | 69 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Caudoviricetes",
"Eukaryota",
"metagenomes"
] | [
21,
512,
7,
4385,
10
] | 5 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
2,
3,
2
] | 3 | true | Family | LAGLIDADG Homing Endonuclease | LAGLIDADG Homing Endonuclease | LAGLIDADG_Endonuclease | 3 |
IPR051291 | 51,291 | Ciliary Microtubule Associated | CIMAP | Family | 6,673 | true | false | The CIMAP family proteins are associated with the structure and function of the sperm tail, specifically the outer dense fibers. These fibers are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail. The CIMAP family proteins are thought to play a ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR21580"
] | [
"CIMAP"
] | [
6673
] | 1 | [] | [] | [] | 0 | [
"8iyj",
"8otz",
"8snb",
"9cpb",
"9e5c",
"9e78",
"9fqr"
] | 7 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
6673
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
14,
15,
10,
11,
18
] | 5 | true | Family | Ciliary Microtubule Associated | Ciliary Microtubule Associated | CIMAP | 4 |
IPR051292 | 51,292 | Alpha-1,3-xylosyltransferase/Beta-1,3-glucuronyltransferase | Xyl/GlcA_transferase | Family | 5,756 | true | false | The protein family is characterized by bifunctional glycosyltransferase activities, specifically alpha-1,3-xylosyltransferase and beta-1,3-glucuronyltransferase. These enzymes are involved in the post-translational modification of alpha-dystroglycan (DAG1), a process crucial for its ability to bind laminin G-like domai... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR12270"
] | [
"Xyl/GlcA_transferase"
] | [
5756
] | 1 | [
"EC",
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"... | [
"2.4.1.-",
"2.4.2.-",
"PWY-1901",
"PWY-1961",
"PWY-1981",
"PWY-2021",
"PWY-2881",
"PWY-2901",
"PWY-2902",
"PWY-4421",
"PWY-4801",
"PWY-5094",
"PWY-5105",
"PWY-5129",
"PWY-5139",
"PWY-5160",
"PWY-5161",
"PWY-5268",
"PWY-5284",
"PWY-5286",
"PWY-5310",
"PWY-5312",
"PWY-5313"... | [
"EC:2.4.1.-",
"EC:2.4.2.-",
"METACYC:PWY-1901",
"METACYC:PWY-1961",
"METACYC:PWY-1981",
"METACYC:PWY-2021",
"METACYC:PWY-2881",
"METACYC:PWY-2901",
"METACYC:PWY-2902",
"METACYC:PWY-4421",
"METACYC:PWY-4801",
"METACYC:PWY-5094",
"METACYC:PWY-5105",
"METACYC:PWY-5129",
"METACYC:PWY-5139",
... | 211 | [
"7ui6",
"7ui7",
"7zvj",
"9e1t"
] | 4 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Gelidibacter salicanalis"
] | [
5755,
1
] | 2 | [
"Caenorhabditis elegans",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
8,
27,
8,
11
] | 5 | true | Family | Alpha-1,3-xylosyltransferase/Beta-1,3-glucuronyltransferase | Alpha-1,3-xylosyltransferase/Beta-1,3-glucuronyltransferase | Xyl/GlcA_transferase | 8 |
IPR051293 | 51,293 | Microtubule-associated tumor suppressor/Coiled-coil domain-containing protein 69 | MTUS1/CCDC69 | Family | 5,385 | true | true | CCDC69 acts as a scaffold to regulate the recruitment and assembly of spindle midzone components. CCDC69 is required for the localisation of AURKB and PLK1 to the spindle midzone. During cell division, CCDC69 localises along overlapping interpolar microtubules in early anaphase, concentrates at the spindle midzone cent... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR24200"
] | [
"MTUS1/CCDC69"
] | [
5385
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00162173",
"PUB00162174",
"PUB00162515",
"PUB00162516"
] | [
"20962590",
"17068200",
"30651135",
"39638803"
] | [
"Role of a novel coiled-coil domain-containing protein CCDC69 in regulating central spindle assembly.",
"Angiotensin II-induced neural differentiation via angiotensin II type 2 (AT2) receptor-MMS2 cascade involving interaction between AT2 receptor-interacting protein and Src homology 2 domain-containing protein-t... | [
2010,
2007,
2019,
2024
] | 4 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
5385
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
35,
14,
9,
17,
19
] | 5 | true | Family | Microtubule-associated tumor suppressor/Coiled-coil domain-containing protein 69 | Microtubule-associated tumor suppressor/Coiled-coil domain-containing protein 69 | MTUS1/CCDC69 | 3 |
IPR051294 | 51,294 | HORMA Domain-Containing Meiotic Progression | HORMA_MeioticProgression | Family | 4,694 | true | false | The HORMA domain-containing protein family is essential for proper meiotic progression in eukaryotes. Members of this family play multiple roles during meiosis, including the regulation of DNA double-strand break (DSB) processing, synaptonemal complex formation, and activation of the ATR kinase in response to unsynapse... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR48225"
] | [
"HORMA_MeioticProgression"
] | [
4694
] | 1 | [] | [] | [] | 0 | [
"4trk",
"4tzj",
"8cxk",
"8j69"
] | 4 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
4694
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Zea mays"
] | [
9,
2,
4,
6,
4,
11,
8,
1,
10
] | 9 | true | Family | HORMA Domain-Containing Meiotic Progression | HORMA Domain-Containing Meiotic Progression | HORMA_MeioticProgression | 9 |
IPR051295 | 51,295 | Leucine-rich glioma-inactivated/LGI-related | LGI_related | Family | 4,590 | true | false | This family of proteins includes regulators of voltage-gated potassium channels, influencing inactivation kinetics by interacting with specific channel subunits. They serve as ligands for certain ADAM metallopeptidase domain proteins, modulating synaptic transmission through AMPA-type glutamate receptors. Members of th... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR24367"
] | [
"LGI_related"
] | [
4590
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-5682910",
"R-HSA-5682910",
"R-MMU-5682910",
"R-RNO-5682910"
] | [
"REACTOME:R-BTA-5682910",
"REACTOME:R-HSA-5682910",
"REACTOME:R-MMU-5682910",
"REACTOME:R-RNO-5682910"
] | 4 | [
"2v70",
"5y2z",
"5y30",
"5y31",
"7la8",
"8hpw",
"8hpx",
"8hpy",
"8hq1",
"8hq2",
"8y6b",
"9kzc",
"9kzt"
] | 13 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Anaerohalosphaera lusitana",
"Metazoa"
] | [
1,
4589
] | 2 | [
"Caenorhabditis elegans",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
13,
25,
15,
17
] | 5 | true | Family | Leucine-rich glioma-inactivated/LGI-related | Leucine-rich glioma-inactivated/LGI-related | LGI_related | 6 |
IPR051296 | 51,296 | Cdc42 Effector Protein BORG/CEP | Cdc42_Effector_BORG/CEP | Family | 4,324 | true | false | The BORG/CEP family is involved in the organization of the actin cytoskeleton and may function downstream of CDC42, a small GTPase of the Rho-subfamily, which regulates signaling pathways that control diverse cellular functions including cell morphology, migration, endocytosis, and cell cycle progression. Members of th... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR15344"
] | [
"Cdc42_Effector_BORG/CEP"
] | [
4324
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-5687128",
"R-BTA-9013149",
"R-BTA-9013404",
"R-BTA-9013406",
"R-BTA-9013408",
"R-BTA-9013423",
"R-HSA-5687128",
"R-HSA-9013148",
"R-HSA-9013149",
"R-HSA-9013404",
"R-HSA-9013406",
"R-HSA-9013408",
"R-HSA-9013409",
"R-HSA-9013423",
"R-MMU-5687128",
"R-MMU-9013149",
"R-MMU-90134... | [
"REACTOME:R-BTA-5687128",
"REACTOME:R-BTA-9013149",
"REACTOME:R-BTA-9013404",
"REACTOME:R-BTA-9013406",
"REACTOME:R-BTA-9013408",
"REACTOME:R-BTA-9013423",
"REACTOME:R-HSA-5687128",
"REACTOME:R-HSA-9013148",
"REACTOME:R-HSA-9013149",
"REACTOME:R-HSA-9013404",
"REACTOME:R-HSA-9013406",
"REACTOM... | 25 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bilateria"
] | [
4324
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
18,
15,
14,
10
] | 4 | true | Family | Cdc42 Effector Protein BORG/CEP | Cdc42 Effector Protein BORG/CEP | Cdc42_Effector_BORG/CEP | 7 |
IPR051297 | 51,297 | PalB/RIM13 Calpain-like | PalB/RIM13 | Family | 4,317 | false | false | This entry represents the PalB/RIM13 subfamily of the peptidase C2 family and calpain proteins found in eukaryotes. The Calpain-like protease palB/RIM13 proteins are involved in the proteolytic cleavage of transcription factors in response to alkaline ambient pH. These proteins are crucial for the initial proteolytic c... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46143"
] | [
""
] | [
4317
] | 1 | [
"EC",
"REACTOME",
"REACTOME"
] | [
"3.4.22.-",
"R-HSA-1474228",
"R-MMU-1474228"
] | [
"EC:3.4.22.-",
"REACTOME:R-HSA-1474228",
"REACTOME:R-MMU-1474228"
] | 3 | [
"2qfe",
"8uc6"
] | 2 | [
"PUB00087078",
"PUB00160502",
"PUB00160503"
] | [
"3016485",
"15686555",
"7499363"
] | [
"Regulation of gene expression by pH of the growth medium in Aspergillus nidulans.",
"The Aspergillus pH-responsive transcription factor PacC regulates virulence.",
"Signaling of ambient pH in Aspergillus involves a cysteine protease."
] | [
1986,
2005,
1995
] | 3 | [] | [] | 0 | 0 | null | [
"Candidatus Magnetoglobus multicellularis str. Araruama",
"Eukaryota",
"viral metagenome"
] | [
1,
4314,
2
] | 3 | [
"Caenorhabditis elegans",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)"
] | [
1,
1,
5,
2,
2,
3,
1
] | 7 | true | Family | PalB/RIM13 Calpain-like | PalB/RIM13 Calpain-like | PalB/RIM13 | 5 |
IPR051298 | 51,298 | Heme transport and cell adhesion protein | Heme_transport/Cell_adhesion | Family | 4,418 | true | false | This family of proteins includes members that are involved in various biological processes, including the transport and breakdown of heme, cell adhesion, spreading, and inhibition of the membrane-damaging effect of the terminal cytolytic complement pathway. Some family members bind heme and transport it to the liver fo... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR22917"
] | [
"Heme_transport/Cell_adhesion"
] | [
4418
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-2129379",
"R-HSA-216083",
"R-HSA-2168880",
"R-HSA-3000170",
"R-HSA-3000178",
"R-HSA-977606",
"R-HSA-9925563",
"R-MMU-2129379",
"R-MMU-216083",
"R-MMU-2168880",
"R-MMU-3000170",
"R-MMU-3000178",
"R-MMU-977606",
"R-RNO-2168880",
"R-SSC-2129379",
"R-SSC-216083",
"R-SSC-3000170",
... | [
"REACTOME:R-HSA-2129379",
"REACTOME:R-HSA-216083",
"REACTOME:R-HSA-2168880",
"REACTOME:R-HSA-3000170",
"REACTOME:R-HSA-3000178",
"REACTOME:R-HSA-977606",
"REACTOME:R-HSA-9925563",
"REACTOME:R-MMU-2129379",
"REACTOME:R-MMU-216083",
"REACTOME:R-MMU-2168880",
"REACTOME:R-MMU-3000170",
"REACTOME:R... | 19 | [
"1oc0",
"1pex",
"1qhu",
"1qjs",
"1s4g",
"1ssu",
"2jq8",
"2jxy",
"3bt1",
"3bt2",
"4k24",
"4rt6",
"6o5e",
"7rj9",
"7txr",
"7u68"
] | 16 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"ecological metagenomes"
] | [
10,
85,
4317,
4,
2
] | 5 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
17,
1,
16,
9,
14
] | 6 | true | Family | Heme transport and cell adhesion protein | Heme transport and cell adhesion protein | Heme_transport/Cell_adhesion | 8 |
IPR051299 | 51,299 | Alpha/beta hydrolase lipase/esterase | AB_hydrolase_lip/est | Family | 3,282 | true | true | This entry represents a group of fungal proteins with an α/β hydrolase fold. Members of this family are involved in the hydrolysis of various ester bonds, playing roles in plant virulence, degradation of plant cell walls, and lipid metabolism. Members of the family exhibit lipase activity, targeting mono-, di-, and tri... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46640"
] | [
"AB_hydrolase_lip/est"
] | [
3282
] | 1 | [
"EC"
] | [
"3.1.1"
] | [
"EC:3.1.1"
] | 1 | [
"1dt3",
"1dt5",
"1dte",
"1du4",
"1ein",
"1gt6",
"1tia",
"1tib",
"1usw",
"1uwc",
"1uza",
"2bjh",
"2hl6",
"2ix9",
"3g7n",
"3o0d",
"4dyh",
"4ea6",
"4flf",
"4gbg",
"4ghw",
"4gi1",
"4glb",
"4gwl",
"4jei",
"4kjx",
"4n8s",
"4s0x",
"4zgb",
"5ap9",
"5ch8",
"5xk2"... | 44 | [
"PUB00155252",
"PUB00155253",
"PUB00155254"
] | [
"15716038",
"26580812",
"9406381"
] | [
"Mutational analysis of a feruloyl esterase from Aspergillus awamori involved in substrate discrimination and pH dependence.",
"Comprehensive Analysis of a Yeast Lipase Family in the Yarrowia Clade.",
"The faeA genes from Aspergillus niger and Aspergillus tubingensis encode ferulic acid esterases involved in de... | [
2005,
2015,
1997
] | 3 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota"
] | [
4,
3278
] | 2 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)"
] | [
1,
1
] | 2 | true | Family | Alpha/beta hydrolase lipase/esterase | Alpha/beta hydrolase lipase/esterase | AB_hydrolase_lip/est | 7 |
IPR051300 | 51,300 | HMX Homeobox Transcription Factors | HMX_Homeobox_TF | Family | 3,453 | true | false | The HMX homeobox family comprises transcription factors involved in the development and specification of neuronal cell types, particularly within the inner ear and hypothalamus. Members of this family are known to bind specific DNA core sequences, such as 5'-CAAG-3' and 5'-CAAGTG-3', to regulate gene expression. These ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46110"
] | [
"HMX_Homeobox_TF"
] | [
3453
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eumetazoa"
] | [
3453
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
8,
4,
4,
4,
8
] | 6 | true | Family | HMX Homeobox Transcription Factors | HMX Homeobox Transcription Factors | HMX_Homeobox_TF | 8 |
IPR051301 | 51,301 | Optineurin/NF-kappa-B Essential Modulator | Optineurin/NFkB_EssMod | Family | 2,573 | true | false | The Optineurin/NF-kappa-B essential modulator family is involved in various cellular processes including the maintenance of the Golgi complex, membrane trafficking, exocytosis, and the activation of innate immune responses. Family members interact with myosin VI and Rab8 to facilitate Golgi ribbon formation and regulat... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR31553"
] | [
"Optineurin/NFkB_EssMod"
] | [
2573
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-1169091",
"R-BTA-168638",
"R-BTA-1810476",
"R-BTA-202424",
"R-BTA-2871837",
"R-BTA-445989",
"R-BTA-450302",
"R-BTA-450321",
"R-BTA-4755510",
"R-BTA-5357905",
"R-BTA-5357956",
"R-BTA-5607764",
"R-BTA-5684264",
"R-BTA-5689880",
"R-BTA-5689896",
"R-BTA-9020702",
"R-BTA-933542",
... | [
"REACTOME:R-BTA-1169091",
"REACTOME:R-BTA-168638",
"REACTOME:R-BTA-1810476",
"REACTOME:R-BTA-202424",
"REACTOME:R-BTA-2871837",
"REACTOME:R-BTA-445989",
"REACTOME:R-BTA-450302",
"REACTOME:R-BTA-450321",
"REACTOME:R-BTA-4755510",
"REACTOME:R-BTA-5357905",
"REACTOME:R-BTA-5357956",
"REACTOME:R-B... | 177 | [
"2jvx",
"2jvy",
"2lo4",
"2v4h",
"2zvn",
"2zvo",
"3brt",
"3brv",
"3cl3",
"3f89",
"3fx0",
"3jsv",
"4bwn",
"4owf",
"5aay",
"5aaz",
"5b83",
"5eoa",
"5eof",
"5wq4",
"6mi3",
"6mi4",
"6xx0",
"6yek",
"7tv4",
"8u7c",
"9azj",
"9b0b",
"9b0z",
"9b12"
] | 30 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"bird metagenome"
] | [
2572,
1
] | 2 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
4,
3,
20,
12,
14
] | 5 | true | Family | Optineurin/NF-kappa-B Essential Modulator | Optineurin/NF-kappa-B Essential Modulator | Optineurin/NFkB_EssMod | 3 |
IPR051302 | 51,302 | Dual Ser/Thr and Tyr Protein Kinase | Dual_SerThr-Tyr_Kinase | Family | 2,458 | true | false | The Dual serine/threonine and tyrosine protein kinase family is characterized by its role in regulating ERK phosphorylation downstream of fibroblast growth factor-receptor activation. Members of this family are involved in the regulation of both caspase-dependent apoptosis and caspase-independent cell death pathways. I... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46392"
] | [
"Dual_SerThr-Tyr_Kinase"
] | [
2458
] | 1 | [
"EC"
] | [
"2.7.12.1"
] | [
"EC:2.7.12.1"
] | 1 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Metazoa"
] | [
2458
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
4,
5,
4
] | 4 | true | Family | Dual Ser/Thr and Tyr Protein Kinase | Dual Ser/Thr and Tyr Protein Kinase | Dual_SerThr-Tyr_Kinase | 6 |
IPR051303 | 51,303 | Armadillo repeat-containing X-linked regulator | Armcx_regulator | Family | 2,272 | true | false | This family of proteins is involved in the regulation of mitochondrial dynamics, particularly affecting the distribution and transport of mitochondria within neural cells. Members of this family may interact with components of the Trak-kinesin motor complex, linking mitochondria to motor proteins and influencing their ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR15712"
] | [
"Armcx_regulator"
] | [
2272
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-9013404",
"R-MMU-9013404",
"R-RNO-9013404"
] | [
"REACTOME:R-HSA-9013404",
"REACTOME:R-MMU-9013404",
"REACTOME:R-RNO-9013404"
] | 3 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
2272
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
2,
21,
12,
15
] | 5 | true | Family | Armadillo repeat-containing X-linked regulator | Armadillo repeat-containing X-linked regulator | Armcx_regulator | 7 |
IPR051304 | 51,304 | SCF Complex F-box Domain-containing Protein | SCF_F-box_domain | Family | 3,017 | true | false | This family of proteins includes members that are typically involved in the ubiquitin-proteasome pathway. They function as components of SCF (SKP1-cullin-F-box) E3 ubiquitin ligase complexes, which play a crucial role in targeting specific proteins for ubiquitination and subsequent degradation by the proteasome. This r... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR47123"
] | [
"SCF_F-box_domain"
] | [
3017
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Mesangiospermae"
] | [
3017
] | 1 | [
"Arabidopsis thaliana"
] | [
85
] | 1 | true | Family | SCF Complex F-box Domain-containing Protein | SCF Complex F-box Domain-containing Protein | SCF_F-box_domain | 8 |
IPR051305 | 51,305 | tRNA-specific 2-thiouridylase MnmA | tRNA_2-thiouridylase_MnmA | Family | 1,615 | true | false | This family of proteins is involved in the post-transcriptional modification of tRNA molecules. Specifically, they catalyze the 2-thiolation of uridine at the wobble position of tRNA, which is the 34th nucleotide from the 5' end of the tRNA sequence. The enzymatic activity results in the formation of 2-thiouridine (s(2... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR43052"
] | [
"tRNA_2-thiouridylase_MnmA"
] | [
1615
] | 1 | [
"EC",
"METACYC",
"METACYC"
] | [
"2.8.1.13",
"PWY-7887",
"PWY-7892"
] | [
"EC:2.8.1.13",
"METACYC:PWY-7887",
"METACYC:PWY-7892"
] | 3 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
564,
1029,
22
] | 3 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
6,
4,
10
] | 3 | true | Family | tRNA-specific 2-thiouridylase MnmA | tRNA-specific 2-thiouridylase MnmA | tRNA_2-thiouridylase_MnmA | 5 |
IPR051306 | 51,306 | Homeobox domain-containing regulator | Homeobox_regulator | Family | 1,517 | true | false | This family of proteins includes transcriptional regulators with homeobox domains that are involved in early embryonic development, axis formation, and myogenesis. Members of this family can act as transcriptional activators or repressors, binding to specific DNA elements to regulate gene expression. Some proteins with... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46123"
] | [
"Homeobox_regulator"
] | [
1517
] | 1 | [
"REACTOME"
] | [
"R-HSA-9819196"
] | [
"REACTOME:R-HSA-9819196"
] | 1 | [
"5z2s",
"5z2t",
"5z6z",
"5zfw",
"5zfy",
"5zfz",
"6a8r",
"6dfy",
"6e8c",
"6u81",
"6u82",
"7dw5",
"8ejo",
"8ejp"
] | 14 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Gammaproteobacteria"
] | [
1515,
2
] | 2 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
44,
13,
4
] | 4 | true | Family | Homeobox domain-containing regulator | Homeobox domain-containing regulator | Homeobox_regulator | 3 |
IPR051307 | 51,307 | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 4 | OST4 | Family | 1,140 | true | false | The OST4 family consists of subunits within the oligosaccharyl transferase (OST) complex, which is pivotal for protein N-glycosylation. These subunits facilitate the transfer of a specific glycan, Glc(3)Man(9)GlcNAc(2), from dolichol-pyrophosphate to an asparagine residue in nascent polypeptide chains. This transfer oc... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR48164"
] | [
"OST4"
] | [
1140
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-446203",
"R-HSA-9694548",
"R-HSA-9768727",
"R-MMU-9768727",
"R-RNO-9768727"
] | [
"REACTOME:R-HSA-446203",
"REACTOME:R-HSA-9694548",
"REACTOME:R-HSA-9768727",
"REACTOME:R-MMU-9768727",
"REACTOME:R-RNO-9768727"
] | 5 | [
"2lat",
"6ftg",
"6fti",
"6ftj",
"6s7o",
"6s7t",
"8b6l",
"8pn9"
] | 8 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Opisthokonta"
] | [
1140
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus"
] | [
1,
1,
2,
1,
1,
1,
1
] | 7 | true | Family | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 4 | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 4 | OST4 | 6 |
IPR051308 | 51,308 | Plant Proline-Rich Cell Wall Protein | Proline-rich_CW_protein | Family | 762 | true | false | This family of proteins includes developmentally regulated cell wall proteins, primarily from plants, which are rich in proline residues. Members of this family are involved in various stages of plant development and interactions with symbiotic organisms. Some proteins are implicated in the modification of cell-wall st... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR34629"
] | [
"Proline-rich_CW_protein"
] | [
762
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota"
] | [
5,
757
] | 2 | [
"Arabidopsis thaliana"
] | [
4
] | 1 | true | Family | Plant Proline-Rich Cell Wall Protein | Plant Proline-Rich Cell Wall Protein | Proline-rich_CW_protein | 8 |
IPR051309 | 51,309 | ABC transporter ABCF subfamily ATPase | ABCF_ATPase | Family | 60,057 | true | false | This family of proteins is part of the ATP-binding cassette (ABC) transporter superfamily, specifically within the ABCF subfamily. Members are involved in various cellular processes, including ribosome assembly or function, and may play a role in the resolution of branched DNA intermediates arising from template switch... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR42855"
] | [
"ABCF_ATPase"
] | [
60057
] | 1 | [] | [] | [] | 0 | [
"5zlu",
"6ha8",
"7nhk",
"7p7q",
"7p7r",
"7p7s",
"7p7t",
"9nlj"
] | 8 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Sym plasmid",
"unclassified Caudoviricetes",
"unclassified sequences"
] | [
16,
57669,
1365,
1,
2,
1004
] | 6 | [
"Arabidopsis thaliana",
"Escherichia coli (strain K12)",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
9,
1,
4,
3
] | 4 | true | Family | ABC transporter ABCF subfamily ATPase | ABC transporter ABCF subfamily ATPase | ABCF_ATPase | 7 |
IPR051311 | 51,311 | DedA domain-containing protein | DedA_domain | Family | 38,852 | true | false | This family of proteins includes members that are involved in the transport of undecaprenyl phosphate (UndP) across the cytoplasmic membrane. These proteins function as flippases, facilitating the movement of UndP from the external side to the cytoplasmic side of the membrane. This process is crucial for the recycling ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR42709"
] | [
"DedA_domain"
] | [
38852
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
976,
37323,
19,
534
] | 4 | [
"Escherichia coli (strain K12)"
] | [
2
] | 1 | true | Family | DedA domain-containing protein | DedA domain-containing protein | DedA_domain | 5 |
IPR051313 | 51,313 | Bacterial iron-siderophore binding | Bact_iron-sidero_bind | Family | 42,221 | true | false | The bacterial solute-binding protein 8 family is involved in the uptake of iron through various siderophores, which are molecules that bind and transport iron into cells. Members of this family are typically part of ABC transporter complexes and function as periplasmic binding proteins. They bind iron complexes such as... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR30532"
] | [
"Bact_iron-sidero_bind"
] | [
42221
] | 1 | [
"REACTOME",
"REACTOME"
] | [
"R-HSA-9638334",
"R-HSA-9638482"
] | [
"REACTOME:R-HSA-9638334",
"REACTOME:R-HSA-9638482"
] | 2 | [
"1efd",
"1esz",
"1k2v",
"1k7s",
"2chu",
"2m6k",
"2m6l",
"2phz",
"2why",
"2wi8",
"2x4l",
"2xuz",
"2xv1",
"3be5",
"3be6",
"3eiw",
"3eix",
"3g9q",
"3gfv",
"3hxp",
"3lhs",
"3li2",
"3mwf",
"3mwg",
"3r5s",
"3r5t",
"3tef",
"3tlk",
"3tny",
"3zkw",
"4b8y",
"4fil"... | 89 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Methanobacteriota",
"unclassified sequences"
] | [
40633,
26,
1456,
106
] | 4 | [
"Escherichia coli (strain K12)"
] | [
3
] | 1 | true | Family | Bacterial iron-siderophore binding | Bacterial iron-siderophore binding | Bact_iron-sidero_bind | 5 |
IPR051314 | 51,314 | AAA ATPase RarA/MGS1/WRNIP1 | AAA_ATPase_RarA/MGS1/WRNIP1 | Family | 31,034 | true | false | This family of proteins includes ATPases associated with various cellular activities, particularly those involved in DNA replication and repair processes. Members of this family are characterized by an AAA ATPase domain that provides energy for their functions through the hydrolysis of ATP. They play crucial roles in r... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR13779"
] | [
"AAA_ATPase_RarA/MGS1/WRNIP1"
] | [
31034
] | 1 | [] | [] | [] | 0 | [
"2qw6",
"2r9g",
"3bge",
"3ctd",
"3pvs",
"8g28"
] | 6 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
5,
26436,
4004,
3,
586
] | 5 | [
"Arabidopsis thaliana",
"Danio rerio",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (s... | [
5,
2,
1,
2,
1,
1,
5,
1,
1
] | 9 | true | Family | AAA ATPase RarA/MGS1/WRNIP1 | AAA ATPase RarA/MGS1/WRNIP1 | AAA_ATPase_RarA/MGS1/WRNIP1 | 7 |
IPR051315 | 51,315 | Bacterial Chemotaxis Sensor Histidine Kinase CheA | Bact_Chemotaxis_CheA | Family | 28,169 | true | false | The CheA protein family is central to bacterial chemotaxis, a process where bacteria navigate their environment by moving towards favorable chemical stimuli and away from harmful ones. Members of the CheA family function as sensor histidine kinases that autophosphorylate in response to signals from chemoreceptors. Once... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR43395"
] | [
"Bact_Chemotaxis_CheA"
] | [
28169
] | 1 | [
"EC"
] | [
"2.7.13.3"
] | [
"EC:2.7.13.3"
] | 1 | [
"1b3q",
"1i58",
"1i59",
"1i5a",
"1i5b",
"1i5c",
"1i5d",
"1i5n",
"1tqg",
"2ch4",
"2ld6",
"2lp4",
"3ja6",
"3kyi",
"3kyj",
"3ur1",
"4jpb",
"4xiv",
"6ff6",
"6mi6",
"6s1k",
"8c5v",
"8oyq",
"8oyz",
"8oz9",
"8p3n",
"8p3r",
"8p59",
"8pf2"
] | 29 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
590,
27096,
66,
417
] | 4 | [
"Escherichia coli (strain K12)",
"Homo sapiens"
] | [
1,
1
] | 2 | true | Family | Bacterial Chemotaxis Sensor Histidine Kinase CheA | Bacterial Chemotaxis Sensor Histidine Kinase CheA | Bact_Chemotaxis_CheA | 9 |
IPR051316 | 51,316 | Zinc-regulated GTPase metalloprotein activator | Zinc-reg_GTPase_activator | Family | 34,482 | true | false | This family of proteins functions as zinc chaperones, facilitating the transfer of zinc ions to target metalloproteins, which results in their activation. The proteins possess a GTPase domain with a CXCC motif that binds zinc and, upon GTP hydrolysis, transfers the zinc to specific binding sites on metalloproteins. Thi... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR13748"
] | [
"Zinc-reg_GTPase_activator"
] | [
34482
] | 1 | [
"EC"
] | [
"3.6.5.-"
] | [
"EC:3.6.5.-"
] | 1 | [
"1nij",
"4ixm",
"4ixn"
] | 3 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
242,
25462,
8588,
190
] | 4 | [
"Arabidopsis thaliana",
"Danio rerio",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)... | [
13,
2,
2,
37,
1,
2,
10,
10,
1,
1,
12
] | 11 | true | Family | Zinc-regulated GTPase metalloprotein activator | Zinc-regulated GTPase metalloprotein activator | Zinc-reg_GTPase_activator | 4 |
IPR051317 | 51,317 | Gfo/Idh/MocA family oxidoreductases | Gfo/Idh/MocA_oxidoreduct | Family | 35,690 | true | false | The Gfo/Idh/MocA family includes a diverse set of oxidoreductases involved in various metabolic processes. Members of this family are characterized by their ability to catalyze oxidation-reduction reactions pivotal to the metabolism of sugars and other compounds. Functions of characterized members include the catabolis... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR43708"
] | [
"Gfo/Idh/MocA_oxidoreduct"
] | [
35690
] | 1 | [] | [] | [] | 0 | [
"1tlt",
"1xea",
"2nvw",
"2p2s",
"3bts",
"3btu",
"3btv",
"3dty",
"3e18",
"3e1k",
"3e82",
"3f4l",
"3fd8",
"3fhl",
"3gdo",
"3gfg",
"3hnp",
"3i23",
"3kux",
"3m2t",
"3uuw",
"3v2u",
"3v5n",
"5uhw",
"5uhz",
"5ui9",
"5uia",
"5uib",
"7d5m",
"7d5n",
"8w9s"
] | 31 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
172,
31187,
3899,
432
] | 4 | [
"Escherichia coli (strain K12)",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
3,
2,
1,
2
] | 4 | true | Family | Gfo/Idh/MocA family oxidoreductases | Gfo/Idh/MocA family oxidoreductases | Gfo/Idh/MocA_oxidoreduct | 7 |
IPR051318 | 51,318 | Iron-sulphur-dependent L-serine dehydratase | Fe-S_L-Ser | Family | 30,723 | true | true | The iron-sulfur dependent L-serine dehydratase family is characterised by enzymes that catalyse the deamination of L-serine to pyruvate and ammonia, a reaction that plays a crucial role in the metabolism of serine and in the overall carbon and nitrogen balance within the cell. Some members of the family are also known ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR30182"
] | [
"FeS_L-Serine_Dehydratase"
] | [
30723
] | 1 | [
"EC"
] | [
"4.3.1.17"
] | [
"EC:4.3.1.17"
] | 1 | [
"2iaf",
"2iqq",
"4rqo"
] | 3 | [] | [] | [] | [] | 0 | [] | [
"IPR004642",
"IPR004643",
"IPR004644"
] | 0 | 3 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
27,
29559,
930,
207
] | 4 | [
"Escherichia coli (strain K12)"
] | [
3
] | 1 | true | Family | Iron-sulphur-dependent L-serine dehydratase | Iron-sulphur-dependent L-serine dehydratase | Fe-S_L-Ser | 6 |
IPR051319 | 51,319 | Bifunctional oligoribonuclease/pAp-phosphatase and c-di-AMP PDE | Oligoribo/pAp-PDE_c-di-AMP_PDE | Family | 22,325 | true | false | The protein family includes bifunctional enzymes with oligoribonuclease and pAp-phosphatase activities, degrading RNA and DNA oligonucleotides up to 33 nucleotides in length, with a preference for shorter substrates. They convert 3'(2')-phosphoadenosine 5'-phosphate (PAP) to AMP, playing a role in RNA metabolism and re... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR47618"
] | [
"Oligoribo/pAp-PDE_c-di-AMP_PDE"
] | [
22325
] | 1 | [
"EC",
"METACYC",
"METACYC"
] | [
"3.6.1.1",
"PWY-7805",
"PWY-7807"
] | [
"EC:3.6.1.1",
"METACYC:PWY-7805",
"METACYC:PWY-7807"
] | 3 | [
"1i74",
"1k20",
"1wpn",
"1wpp",
"2enx",
"3dev",
"3w5w",
"4ls9",
"4py9",
"5cet",
"5ipp",
"5iuf",
"5izo",
"5j21",
"5jju",
"5o1u",
"5o25",
"5o4z",
"5o58",
"5o70",
"5o7f",
"5xsi",
"5xsn",
"5xsp",
"5xt3",
"8ioo",
"8iu7"
] | 27 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Caudoviricetes",
"Eukaryota",
"unclassified sequences"
] | [
1788,
20132,
2,
65,
338
] | 5 | [] | [] | 0 | true | Family | Bifunctional oligoribonuclease/pAp-phosphatase and c-di-AMP PDE | Bifunctional oligoribonuclease/pAp-phosphatase and c-di-AMP PDE | Oligoribo/pAp-PDE_c-di-AMP_PDE | 3 |
IPR051320 | 51,320 | Viral Replication and Maturation Polyprotein | Viral_Replic_Matur_Polypro | Family | 318,288 | true | false | The protein family is involved in the replication and maturation of viral genomes. Members encode polyproteins that are processed to yield proteases and reverse transcriptases. The protease activity cleaves the polyprotein in cis, while the reverse transcriptase exhibits DNA polymerase activity, copying DNA or RNA temp... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR33064"
] | [
"Viral_Replic_Matur_Polypro"
] | [
318288
] | 1 | [
"EC",
"EC",
"EC"
] | [
"2.7.7.49",
"2.7.7.7",
"3.1.26.4"
] | [
"EC:2.7.7.49",
"EC:2.7.7.7",
"EC:3.1.26.4"
] | 3 | [
"1d0e",
"1d1u",
"1har",
"1i6j",
"1mml",
"1n4l",
"1nnd",
"1qai",
"1qaj",
"1ztt",
"1ztw",
"2fjv",
"2fjw",
"2fjx",
"2fvp",
"2fvq",
"2fvr",
"2fvs",
"2r2r",
"2r2s",
"2r2t",
"2r2u",
"3fsi",
"4hkq",
"4m94",
"4m95",
"4mh8",
"4xo0",
"4xpc",
"4xpe",
"5dmq",
"5vbs"... | 59 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Viruses",
"invertebrate metagenome"
] | [
35,
31040,
287212,
1
] | 4 | [
"Arabidopsis thaliana",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
3,
1,
5,
4,
28,
2,
2
] | 7 | true | Family | Viral Replication and Maturation Polyprotein | Viral Replication and Maturation Polyprotein | Viral_Replic_Matur_Polypro | 8 |
IPR051321 | 51,321 | Polyhydroxyalkanoate Synthase | PHA/PHB_synthase | Family | 21,638 | true | false | The PHA/PHB synthase family is involved in the biosynthesis of polyhydroxyalkanoates (PHAs), which are biopolymers synthesized by various microorganisms as intracellular energy reserves under nutrient-limiting conditions. The primary function of the family members is to polymerize 3-hydroxybutyryl-CoA into poly(3-hydro... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR36837"
] | [
"PHA/PHB_synthase"
] | [
21638
] | 1 | [
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC"... | [
"2.3.1.-",
"PWY-3602",
"PWY-361",
"PWY-4801",
"PWY-4922",
"PWY-5048",
"PWY-5139",
"PWY-5268",
"PWY-5284",
"PWY-5292",
"PWY-5307",
"PWY-5313",
"PWY-5317",
"PWY-5318",
"PWY-5353",
"PWY-5400",
"PWY-5473",
"PWY-5475",
"PWY-5477",
"PWY-5660",
"PWY-5679",
"PWY-5710",
"PWY-5794"... | [
"EC:2.3.1.-",
"METACYC:PWY-3602",
"METACYC:PWY-361",
"METACYC:PWY-4801",
"METACYC:PWY-4922",
"METACYC:PWY-5048",
"METACYC:PWY-5139",
"METACYC:PWY-5268",
"METACYC:PWY-5284",
"METACYC:PWY-5292",
"METACYC:PWY-5307",
"METACYC:PWY-5313",
"METACYC:PWY-5317",
"METACYC:PWY-5318",
"METACYC:PWY-53... | 219 | [
"5hz2",
"5t6o",
"5xav",
"6k3c",
"9knj",
"9knk",
"9knl"
] | 7 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
361,
21048,
45,
184
] | 4 | [] | [] | 0 | true | Family | Polyhydroxyalkanoate Synthase | Polyhydroxyalkanoate Synthase | PHA/PHB_synthase | 1 |
IPR051323 | 51,323 | Alpha-ketoglutarate-dependent sulfate ester dioxygenase-like | AtsK-like | Family | 22,433 | true | true | This entry represents Alpha-ketoglutarate-dependent sulfate ester dioxygenase Pseudomonas putida (AtsK) [ , ] and similar proteins involved in diverse biological processes, including the degradation of sulfonates and sulfate esters, as well as the biosynthesis of natural products such as indole alkaloids and sesterterp... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR30468"
] | [
"Alpha-KG-dependent_dioxygenase"
] | [
22433
] | 1 | [
"EC"
] | [
"1.14.11"
] | [
"EC:1.14.11"
] | 1 | [
"1gqw",
"1gy9",
"1oih",
"1oii",
"1oij",
"1oik",
"1os7",
"1otj",
"1vz4",
"1vz5",
"3pvj",
"3r1j",
"3swt",
"3v15",
"3v17",
"4cvy",
"4ffa",
"4j5i",
"4y0e",
"5bk9",
"5bkb",
"5bkc",
"5bkd",
"5hsx",
"5keu",
"5vn6",
"6d0o",
"6d1o",
"6d3h",
"6d3i",
"6d3j",
"6d3m"... | 39 | [
"PUB00037325",
"PUB00155031"
] | [
"15023059",
"10913158"
] | [
"Crystal structure of the alkylsulfatase AtsK: insights into the catalytic mechanism of the Fe(II) alpha-ketoglutarate-dependent dioxygenase superfamily.",
"Characterization of a sulfur-regulated oxygenative alkylsulfatase from Pseudomonas putida S-313."
] | [
2004,
2000
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Viruses",
"metagenomes",
"uncultured marine group III euryarchaeote KM3-28-E8"
] | [
12485,
9595,
4,
348,
1
] | 5 | [
"Escherichia coli (strain K12)",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
1,
3,
1,
1
] | 4 | true | Family | Alpha-ketoglutarate-dependent sulfate ester dioxygenase-like | Alpha-ketoglutarate-dependent sulfate ester dioxygenase-like | AtsK-like | 2 |
IPR051326 | 51,326 | Kynurenine--oxoglutarate transaminase | Kynurenine-oxoglutarate_AT | Family | 21,548 | true | false | The Kynurenine--oxoglutarate transaminase family includes enzymes that catalyze the irreversible transamination of L-kynurenine to form kynurenic acid, an intermediate in the tryptophan catabolic pathway and a broad-spectrum antagonist of ionotropic excitatory amino acid receptors. Members of the family also metabolize... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR43807"
] | [
"Kynurenine-oxoglutarate_AT"
] | [
21548
] | 1 | [
"EC",
"EC",
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACT... | [
"2.6.1",
"2.6.1.7",
"4.4.1.13",
"PWY-1187",
"PWY-2821",
"PWY-601",
"PWY-6842",
"PWY-6936",
"PWY-7901",
"PWY-801",
"PWY-8302",
"R-DDI-71240",
"R-DDI-8964208",
"R-DDI-8964539",
"R-HSA-71240",
"R-HSA-8964208",
"R-HSA-8964539",
"R-MMU-71240",
"R-MMU-8964208",
"R-MMU-8964539",
"R-... | [
"EC:2.6.1",
"EC:2.6.1.7",
"EC:4.4.1.13",
"METACYC:PWY-1187",
"METACYC:PWY-2821",
"METACYC:PWY-601",
"METACYC:PWY-6842",
"METACYC:PWY-6936",
"METACYC:PWY-7901",
"METACYC:PWY-801",
"METACYC:PWY-8302",
"REACTOME:R-DDI-71240",
"REACTOME:R-DDI-8964208",
"REACTOME:R-DDI-8964539",
"REACTOME:R-H... | 29 | [
"1u08",
"1v2d",
"1v2e",
"1v2f",
"1w7l",
"1w7m",
"1w7n",
"1yiy",
"1yiz",
"2o0r",
"2r5c",
"2r5e",
"2zjg",
"3b46",
"3e2f",
"3e2y",
"3e2z",
"3fvs",
"3fvu",
"3fvx",
"4wlh",
"4wlj",
"4wp0",
"5veh",
"5vep",
"5veq",
"5ver"
] | 27 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
63,
13339,
7991,
155
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
5,
3,
12,
2,
1,
12,
7,
1,
8,
16,
1,
1,
9
] | 13 | true | Family | Kynurenine--oxoglutarate transaminase | Kynurenine--oxoglutarate transaminase | Kynurenine-oxoglutarate_AT | 5 |
IPR051328 | 51,328 | Type VII Secretion & ABC Transporter Permease | T7SS_ABC-Transporter | Family | 21,311 | true | false | This family of proteins includes components of the type VII secretion system (Ess) and ABC transporter permeases. The Ess components, such as EsaA, are involved in forming a secretion platform across the cytoplasmic membrane, working in conjunction with other proteins like EssB, EssC, and EssE to facilitate the secreti... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR43077"
] | [
"T7SS_ABC-Transporter"
] | [
21311
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Enterococcus phage Entfac.YE1",
"Eukaryota",
"metagenomes"
] | [
279,
20753,
1,
199,
79
] | 5 | [] | [] | 0 | true | Family | Type VII Secretion & ABC Transporter Permease | Type VII Secretion & ABC Transporter Permease | T7SS_ABC-Transporter | 5 |
IPR051329 | 51,329 | Nitrite and Sulfite Reductase 4Fe-4S Domain-Containing Protein | NIR_SIR_4Fe-4S | Family | 20,253 | true | false | This family of proteins includes enzymes that are involved in the reduction of nitrite to ammonium and sulfite to sulfide. These reactions are crucial steps in the nitrogen and sulfur assimilation pathways, respectively. The proteins utilize a 4Fe-4S domain to transfer electrons, typically from ferredoxin, to facilitat... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR32439"
] | [
"NIR_SIR_4Fe-4S"
] | [
20253
] | 1 | [
"REACTOME"
] | [
"R-MTU-936721"
] | [
"REACTOME:R-MTU-936721"
] | 1 | [
"1zj8",
"1zj9",
"2akj",
"3b0g",
"3b0h",
"3b0j",
"3b0l",
"3b0m",
"3b0n",
"3vkp",
"3vkq",
"3vkr",
"3vks",
"3vkt",
"3vlx",
"3vly",
"3vlz",
"3vm0",
"3vm1"
] | 19 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
704,
18332,
959,
258
] | 4 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
8,
8,
10
] | 3 | true | Family | Nitrite and Sulfite Reductase 4Fe-4S Domain-Containing Protein | Nitrite and Sulfite Reductase 4Fe-4S Domain-Containing Protein | NIR_SIR_4Fe-4S | 2 |
IPR051330 | 51,330 | Phosphatase regulators and Met sulfoxide reductases | Phosphatase_reg/MetRdx | Family | 16,832 | true | false | This family of proteins includes regulators of serine/threonine-protein phosphatases, particularly PP2A and PP4, and free methionine-R-sulfoxide reductases. Members involved in phosphatase regulation may act as allosteric regulators or inhibitors, affecting the catalytic activity and complex formation of these phosphat... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR21021"
] | [
"Phosphatase_reg/MetRdx"
] | [
16832
] | 1 | [] | [] | [] | 0 | [
"1f5m",
"1vhm",
"3ko6",
"3ksf",
"3ksg",
"3ksh",
"3ksi",
"3mmh",
"3rfb",
"5d9g",
"5hl6",
"5w0w",
"5w0x",
"8dgd"
] | 14 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Marine Group III euryarchaeote CG-Epi1",
"metagenomes"
] | [
10631,
6145,
1,
55
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
4,
1,
2,
1,
1,
1,
1,
2,
2,
6,
2,
1,
10
] | 13 | true | Family | Phosphatase regulators and Met sulfoxide reductases | Phosphatase regulators and Met sulfoxide reductases | Phosphatase_reg/MetRdx | 7 |
IPR051331 | 51,331 | Chorismate mutase-related enzymes | Chorismate_mutase-related | Family | 13,900 | true | false | This family of proteins is involved in the biosynthesis of aromatic amino acids and other aromatic compounds through the Claisen rearrangement of chorismate to prephenate. Members of this family may also participate in the biosynthesis of various secondary metabolites, such as siderophores and antibiotics, by catalyzin... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR38041"
] | [
"Chorismate_mutase-related"
] | [
13900
] | 1 | [
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC"
] | [
"5.4.99.5",
"PWY-3461",
"PWY-3462",
"PWY-6120",
"PWY-6627",
"PWY-7626"
] | [
"EC:5.4.99.5",
"METACYC:PWY-3461",
"METACYC:PWY-3462",
"METACYC:PWY-6120",
"METACYC:PWY-6627",
"METACYC:PWY-7626"
] | 6 | [
"1ecm",
"1ybz",
"2ao2",
"2d8d",
"2d8e",
"2f6l",
"2fp1",
"2fp2",
"2gbb",
"2gtv",
"2h9c",
"2h9d",
"2qbv",
"2vkl",
"2w19",
"2w1a",
"3hgw",
"3hgx",
"3rem",
"3ret",
"3rmi",
"5ckx",
"5gmu",
"5go2",
"5mpv",
"5ts9",
"5vht",
"6al9",
"6cnz",
"6ygt",
"9bt3",
"9bt6"... | 34 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Mimiviridae sp. ChoanoV1",
"metagenomes"
] | [
567,
12944,
239,
1,
149
] | 5 | [] | [] | 0 | true | Family | Chorismate mutase-related enzymes | Chorismate mutase-related enzymes | Chorismate_mutase-related | 7 |
IPR051332 | 51,332 | Fosfomycin Resistance Enzymes | Fosfomycin_Res_Enzymes | Family | 17,823 | true | false | This family of proteins includes enzymes that confer resistance to the antibiotic fosfomycin. Members of this family are involved in the modification of fosfomycin, thereby inactivating its antibacterial properties. The primary mechanism involves the catalysis of the addition of a thiol or glutathione group to fosfomyc... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR36113"
] | [
"Fosfomycin_Res_Enzymes"
] | [
17823
] | 1 | [
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC"... | [
"2.5.1.-",
"PWY-4502",
"PWY-4681",
"PWY-5802",
"PWY-5815",
"PWY-5816",
"PWY-5817",
"PWY-5893",
"PWY-5979",
"PWY-6262",
"PWY-6403",
"PWY-6659",
"PWY-6681",
"PWY-6936",
"PWY-7372",
"PWY-7405",
"PWY-7407",
"PWY-7493",
"PWY-7520",
"PWY-7529",
"PWY-7532",
"PWY-7540",
"PWY-7543... | [
"EC:2.5.1.-",
"METACYC:PWY-4502",
"METACYC:PWY-4681",
"METACYC:PWY-5802",
"METACYC:PWY-5815",
"METACYC:PWY-5816",
"METACYC:PWY-5817",
"METACYC:PWY-5893",
"METACYC:PWY-5979",
"METACYC:PWY-6262",
"METACYC:PWY-6403",
"METACYC:PWY-6659",
"METACYC:PWY-6681",
"METACYC:PWY-6936",
"METACYC:PWY-7... | 43 | [
"1mpy",
"1npb",
"1r9c",
"1xqa",
"2p25",
"2p7k",
"2p7l",
"2p7m",
"2p7o",
"2p7p",
"2p7q",
"3b59",
"3ct8",
"3e5d",
"3kol",
"3l7t",
"3rhe",
"4ir0",
"4jd1",
"4jh1",
"4jh2",
"4jh3",
"4jh4",
"4jh5",
"4jh6",
"4jh7",
"4jh8",
"4jh9",
"4nay",
"4naz",
"4nb0",
"4nb1"... | 42 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Caudoviricetes",
"Eukaryota",
"metagenomes"
] | [
165,
17439,
2,
74,
143
] | 5 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Fosfomycin Resistance Enzymes | Fosfomycin Resistance Enzymes | Fosfomycin_Res_Enzymes | 5 |
IPR051333 | 51,333 | CLIP domain-containing serine protease | CLIP_Serine_Protease | Family | 10,660 | true | false | The CLIP domain-containing serine protease family is involved in innate immune responses across various organisms. Members of this family play key roles in pathogen recognition and activation of immune cascades, particularly in response to infections by parasites, bacteria, and fungi. They are characterized by a clip d... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR24260"
] | [
"CLIP_Serine_Protease"
] | [
10660
] | 1 | [
"EC",
"METACYC",
"REACTOME"
] | [
"3.4.21.-",
"PWY-7884",
"R-DME-209442"
] | [
"EC:3.4.21.-",
"METACYC:PWY-7884",
"REACTOME:R-DME-209442"
] | 3 | [
"1hyl",
"2hlc",
"8w20",
"8w22"
] | 4 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Viruses",
"metagenomes",
"uncultured marine group II/III euryarchaeote KM3_172_F11"
] | [
1767,
8853,
16,
23,
1
] | 5 | [
"Caenorhabditis elegans",
"Drosophila melanogaster"
] | [
3,
58
] | 2 | true | Family | CLIP domain-containing serine protease | CLIP domain-containing serine protease | CLIP_Serine_Protease | 4 |
IPR051335 | 51,335 | Alanyl-tRNA Editing Enzymes | Alanyl-tRNA_Editing_Enzymes | Family | 12,697 | true | false | This family of proteins functions in the editing of tRNA molecules to ensure the correct amino acid is attached. Members of this family act in trans to remove incorrect amino acid moieties from tRNA(Ala), which is charged with alanine. They are responsible for the hydrolytic editing of mischarged Ser-tRNA(Ala) and, in ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR43462"
] | [
"Alanyl-tRNA_Editing_Enzymes"
] | [
12697
] | 1 | [] | [] | [] | 0 | [
"1v4p",
"1v7o",
"1wnu",
"1wxo",
"2e1b",
"3kew",
"3rfn",
"3rhu",
"9iuw"
] | 9 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
625,
7764,
4140,
168
] | 4 | [
"Arabidopsis thaliana",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"... | [
9,
1,
2,
6,
3,
1,
2,
2,
1,
6
] | 10 | true | Family | Alanyl-tRNA Editing Enzymes | Alanyl-tRNA Editing Enzymes | Alanyl-tRNA_Editing_Enzymes | 8 |
IPR051336 | 51,336 | Rho GTPase-activating Guanine Nucleotide Exchange Factors | RhoGEF_Guanine_NuclExch_SF | Family | 19,684 | true | false | The protein family is characterized by its role as guanine nucleotide exchange factors (GEFs) that activate Rho GTPase family members, influencing signaling pathways that regulate neuronal shape, growth, and plasticity. These proteins are involved in actin cytoskeleton reorganization, contributing to cell migration, gr... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR22826"
] | [
"RhoGEF_Guanine_NuclExch_SF"
] | [
19684
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-DRE-193648",
"R-DRE-416476",
"R-DRE-416482",
"R-DRE-418885",
"R-DRE-8980692",
"R-DRE-9013148",
"R-DRE-9013149",
"R-DRE-9013404",
"R-DRE-9013408",
"R-DRE-9013423",
"R-HSA-193634",
"R-HSA-193648",
"R-HSA-3928662",
"R-HSA-416476",
"R-HSA-416482",
"R-HSA-418885",
"R-HSA-5687128",
"R... | [
"REACTOME:R-DRE-193648",
"REACTOME:R-DRE-416476",
"REACTOME:R-DRE-416482",
"REACTOME:R-DRE-418885",
"REACTOME:R-DRE-8980692",
"REACTOME:R-DRE-9013148",
"REACTOME:R-DRE-9013149",
"REACTOME:R-DRE-9013404",
"REACTOME:R-DRE-9013408",
"REACTOME:R-DRE-9013423",
"REACTOME:R-HSA-193634",
"REACTOME:R-H... | 54 | [
"1kz7",
"1kzg",
"1lb1",
"1nty",
"1rj2",
"1wfw",
"2kr9",
"2nz8",
"2rgn",
"5o33",
"5qqd",
"5qqe",
"5qqf",
"5qqg",
"5qqh",
"5qqi",
"5qqj",
"5qqk",
"5qql",
"5qqm",
"5qqn",
"5qu9",
"6d8z",
"7sj4",
"7ur2",
"8c7d"
] | 26 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Nocardioides malaquae"
] | [
19683,
1
] | 2 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
12,
190,
20,
65,
46,
43
] | 6 | true | Family | Rho GTPase-activating Guanine Nucleotide Exchange Factors | Rho GTPase-activating Guanine Nucleotide Exchange Factors | RhoGEF_Guanine_NuclExch_SF | 3 |
IPR051337 | 51,337 | Organophosphate:Pi Antiporter | OPA_Antiporter | Family | 14,277 | true | false | This family of proteins includes transporters that facilitate the exchange of organic phosphate compounds and inorganic phosphate across cellular membranes. Members of this family are predominantly involved in the uptake of hexose-6-phosphate, glycerol-3-phosphate, and other related phosphate esters, which are essentia... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR43826"
] | [
"OPA_Antiporter"
] | [
14277
] | 1 | [
"REACTOME",
"REACTOME"
] | [
"R-HSA-3229133",
"R-HSA-70263"
] | [
"REACTOME:R-HSA-3229133",
"REACTOME:R-HSA-70263"
] | 2 | [
"1pw4",
"9kuy",
"9kv0",
"9kvv"
] | 4 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
120,
11978,
2070,
109
] | 4 | [
"Caenorhabditis elegans",
"Danio rerio",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
5,
4,
14,
6,
5
] | 6 | true | Family | Organophosphate:Pi Antiporter | Organophosphate:Pi Antiporter | OPA_Antiporter | 9 |
IPR051338 | 51,338 | NodU/CmcH Carbamoyltransferase | NodU/CmcH_Carbamoyltrnsfr | Family | 8,587 | true | false | The NodU/CmcH family consists of carbamoyltransferases involved in various biosynthetic pathways. Members of this family play key roles in the modification of natural compounds, such as antibiotics and nodulation factors. For instance, they are responsible for the 3'-carbamoylation of the noviosyl ring in novobiocin bi... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR34847"
] | [
"NodU/CmcH_Carbamoyltrnsfr"
] | [
8587
] | 1 | [
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC"
] | [
"2.1.3.-",
"PWY-5",
"PWY-7693",
"PWY-7694",
"PWY-8039",
"PWY-8344"
] | [
"EC:2.1.3.-",
"METACYC:PWY-5",
"METACYC:PWY-7693",
"METACYC:PWY-7694",
"METACYC:PWY-8039",
"METACYC:PWY-8344"
] | 6 | [
"3ven",
"3veo",
"3ver",
"3ves",
"3vet",
"3vew",
"3vex",
"3vez",
"3vf2",
"3vf4",
"7vx0",
"7vyj",
"7vyo",
"7vyp",
"7vzn",
"7vzq",
"7vzu",
"7vzy",
"7vzz",
"7xb6",
"8hiu",
"9s2t"
] | 22 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Caudoviricetes",
"Eukaryota",
"unclassified sequences"
] | [
230,
7693,
54,
297,
313
] | 5 | [] | [] | 0 | true | Family | NodU/CmcH Carbamoyltransferase | NodU/CmcH Carbamoyltransferase | NodU/CmcH_Carbamoyltrnsfr | 9 |
IPR051339 | 51,339 | DnaJ homolog subfamily B | DnaJ_subfamily_B | Family | 16,089 | true | false | This family of proteins includes molecular chaperones that are involved in the folding of unfolded proteins. They interact with HSP70 heat shock proteins, stimulating ATP hydrolysis and assisting in the proper folding of non-native proteins. Some members are implicated in the regulation of heat shock-induced transcript... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR24078"
] | [
"DnaJ_subfamily_B"
] | [
16089
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-3371453",
"R-BTA-3371497",
"R-BTA-3371568",
"R-BTA-3371571",
"R-BTA-5687128",
"R-HSA-3371453",
"R-HSA-3371497",
"R-HSA-3371568",
"R-HSA-3371571",
"R-HSA-5687128",
"R-MMU-3371453",
"R-MMU-3371497",
"R-MMU-3371568",
"R-MMU-3371571",
"R-MMU-5687128"
] | [
"REACTOME:R-BTA-3371453",
"REACTOME:R-BTA-3371497",
"REACTOME:R-BTA-3371568",
"REACTOME:R-BTA-3371571",
"REACTOME:R-BTA-5687128",
"REACTOME:R-HSA-3371453",
"REACTOME:R-HSA-3371497",
"REACTOME:R-HSA-3371568",
"REACTOME:R-HSA-3371571",
"REACTOME:R-HSA-5687128",
"REACTOME:R-MMU-3371453",
"REACTOM... | 15 | [
"1c3g",
"2b26",
"2q2g",
"2qld",
"3agx",
"3agy",
"3agz",
"7jtk",
"7ndx",
"8glv",
"8j07",
"8wzb",
"8x2u",
"9e5c",
"9fqr"
] | 15 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Viruses",
"metagenomes"
] | [
116,
15841,
26,
106
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
46,
1,
14,
14,
21,
11,
1,
26,
13,
1,
1,
53
] | 12 | true | Family | DnaJ homolog subfamily B | DnaJ homolog subfamily B | DnaJ_subfamily_B | 3 |
IPR051341 | 51,341 | Zyg-11-related ubiquitin ligase adapter protein | Zyg-11_UBL_adapter | Family | 6,507 | true | false | This family of proteins functions as substrate adapter subunits in E3 ubiquitin ligase complexes, which are involved in targeting proteins for proteasomal degradation. Members of this family recognize substrates bearing N-terminal glycine degrons, which are often exposed following caspase cleavage during apoptosis or a... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR12904"
] | [
"Zyg-11_UBL_adapter"
] | [
6507
] | 1 | [] | [] | [] | 0 | [
"4ezg",
"4l3a",
"4l3f",
"7ep0",
"7ep1",
"7ep2",
"7ep3",
"7ep4",
"7ep5",
"7xv7",
"7xys",
"7xyt",
"7xyu",
"7xyv",
"7xyw",
"7xyx",
"7yc2"
] | 17 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Candidatus Iainarchaeum sp.",
"Eukaryota",
"Viruses",
"metagenomes"
] | [
276,
1,
6221,
3,
6
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
6,
26,
7,
2,
9,
8,
1,
3,
11,
9
] | 10 | true | Family | Zyg-11-related ubiquitin ligase adapter protein | Zyg-11-related ubiquitin ligase adapter protein | Zyg-11_UBL_adapter | 9 |
IPR051342 | 51,342 | PDZ domain-containing scaffold protein | PDZ_scaffold | Family | 13,363 | true | false | This family of proteins includes scaffolding proteins that play key roles in cellular signaling, localization, and structural integrity. They are involved in the formation and maintenance of tight junctions and epithelial cell polarity. Some family members act as E3 ubiquitin-protein ligases, mediating ubiquitination a... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR19964"
] | [
"PDZ_scaffold"
] | [
13363
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-DME-983168",
"R-HSA-420029",
"R-HSA-9705677",
"R-HSA-983168",
"R-MMU-983168"
] | [
"REACTOME:R-DME-983168",
"REACTOME:R-HSA-420029",
"REACTOME:R-HSA-9705677",
"REACTOME:R-HSA-983168",
"REACTOME:R-MMU-983168"
] | 5 | [
"1um1",
"1wi4",
"2d92",
"2daz",
"2db5",
"2dlu",
"2dm8",
"2dmz",
"2iwn",
"2jre",
"2o2t",
"2opg",
"2qg1",
"2vwr",
"3b76",
"3r0h",
"3vqf",
"3vqg",
"4q2n",
"4xh7",
"5din",
"5dth",
"5e11",
"5e1y",
"5e21",
"5e22",
"5h7r",
"5h7s",
"6ird",
"6ire",
"6nek",
"7qct"... | 32 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Candidatus Geothrix skivensis",
"Eukaryota"
] | [
1,
13362
] | 2 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
13,
88,
10,
34,
29,
34
] | 6 | true | Family | PDZ domain-containing scaffold protein | PDZ domain-containing scaffold protein | PDZ_scaffold | 6 |
IPR051343 | 51,343 | G-type lectin S-receptor-like kinases and EP1-like glycoproteins | G-type_lectin_kinases/EP1-like | Family | 14,687 | true | false | This family of proteins includes G-type lectin S-receptor-like serine/threonine-protein kinases and EP1-like glycoproteins. The kinases are part of the protein kinase superfamily and are involved in various defense mechanisms in plants. They play a role in innate immunity, resistance to pathogens such as fungi and bact... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR47976"
] | [
"G-type_lectin_kinases/EP1-like"
] | [
14687
] | 1 | [
"EC"
] | [
"2.7.11.1"
] | [
"EC:2.7.11.1"
] | 1 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"freshwater metagenome"
] | [
107,
14579,
1
] | 3 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
28,
85,
53
] | 3 | true | Family | G-type lectin S-receptor-like kinases and EP1-like glycoproteins | G-type lectin S-receptor-like kinases and EP1-like glycoproteins | G-type_lectin_kinases/EP1-like | 3 |
IPR051344 | 51,344 | Virginiamycin B lyase | Vgb | Family | 5,001 | true | false | The Vgb family consists of enzymes known as Virginiamycin B lyases. These enzymes are responsible for inactivating type B streptogramin antibiotics. They achieve this by cleaving the lactone ring at the ester linkage, which results in the formation of a free phenylglycine carboxylate. Additionally, the threonyl moiety ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR40274"
] | [
"Vgb"
] | [
5001
] | 1 | [
"EC",
"METACYC"
] | [
"4.2.99.-",
"PWY-5397"
] | [
"EC:4.2.99.-",
"METACYC:PWY-5397"
] | 2 | [
"2qc5",
"2z2n",
"2z2o",
"2z2p",
"6f0q",
"6i37",
"6rej",
"6rek",
"6rel",
"6rem",
"7zph",
"7zpw",
"7zpz",
"7zq2",
"7zqg"
] | 15 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Myoviridae sp. ctIty1",
"unclassified sequences"
] | [
117,
4496,
271,
1,
116
] | 5 | [] | [] | 0 | true | Family | Virginiamycin B lyase | Virginiamycin B lyase | Vgb | 3 |
IPR051345 | 51,345 | Importin beta-like nuclear transport receptors | Importin_beta-like_NTR | Family | 11,603 | true | false | The importin beta family is involved in the nuclear-cytoplasmic transport of proteins. Members of this family function as nuclear transport receptors, mediating the import of proteins into the nucleus by recognizing nuclear localization signals (NLS) in cargo substrates. They are also involved in the nuclear export of ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR12363"
] | [
"Importin_beta-like_NTR"
] | [
11603
] | 1 | [] | [] | [] | 0 | [
"2x19",
"2x1g",
"2xwu",
"3zjy",
"3zkv",
"4c0o",
"4c0p",
"4c0q",
"4ol0",
"6gx9",
"6q82",
"6q83",
"6q84",
"8cmk"
] | 14 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
11603
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
11,
2,
6,
4,
10,
8,
3,
8,
19,
2,
2,
39
] | 12 | true | Family | Importin beta-like nuclear transport receptors | Importin beta-like nuclear transport receptors | Importin_beta-like_NTR | 2 |
IPR051347 | 51,347 | Circadian clock KaiC-related | Circadian_clock_KaiC-rel | Family | 5,733 | true | false | This family of proteins constitutes the main circadian regulators in cyanobacteria, forming the KaiABC oscillator complex. The proteins undergo autophosphorylation and autodephosphorylation, which are central to the circadian rhythm generation. They exhibit weak, temperature-independent ATPase activity that is crucial ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR42926"
] | [
"Circadian_clock_KaiC-rel"
] | [
5733
] | 1 | [
"EC",
"EC",
"METACYC"
] | [
"2.7.11.1",
"3.6.4.-",
"PWY-7250"
] | [
"EC:2.7.11.1",
"EC:3.6.4.-",
"METACYC:PWY-7250"
] | 3 | [
"1tf7",
"1u9i",
"2gbl",
"3dvl",
"3jzm",
"3k09",
"3k0a",
"3k0c",
"3k0e",
"3k0f",
"3s1a",
"4dug",
"4ijm",
"4o0m",
"4tl6",
"4tl7",
"4tl8",
"4tl9",
"4tla",
"4tlb",
"4tlc",
"4tld",
"4tle",
"5jwo",
"5jwq",
"5jwr",
"5n8y",
"5yz8",
"6x61",
"7dxq",
"7dy1",
"7dy2"... | 56 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences",
"uncultured marine phage"
] | [
463,
5227,
6,
36,
1
] | 5 | [] | [] | 0 | true | Family | Circadian clock KaiC-related | Circadian clock KaiC-related | Circadian_clock_KaiC-rel | 9 |
IPR051348 | 51,348 | U-box domain-containing ubiquitin ligases | U-box_ubiquitin_ligases | Family | 12,707 | true | false | The U-box domain-containing protein family is characterized by its members' role as E3 ubiquitin ligases. These proteins are involved in the ubiquitination process, which tags substrates for degradation by the proteasome, thus regulating protein turnover. Some family members are known to participate in signaling pathwa... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR45647"
] | [
"U-box_ubiquitin_ligases"
] | [
12707
] | 1 | [
"EC",
"METACYC"
] | [
"2.3.2.27",
"PWY-7511"
] | [
"EC:2.3.2.27",
"METACYC:PWY-7511"
] | 2 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
12707
] | 1 | [
"Arabidopsis thaliana",
"Homo sapiens",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
161,
1,
100,
218
] | 4 | true | Family | U-box domain-containing ubiquitin ligases | U-box domain-containing ubiquitin ligases | U-box_ubiquitin_ligases | 8 |
IPR051349 | 51,349 | Hydrogenase complex-associated protein | Hydrogenase_assoc-protein | Family | 3,135 | true | false | This family of proteins is involved in the biological process of hydrogen metabolism. Members of this family are typically part of enzyme complexes that play a role in the reduction of various electron acceptors. Some proteins in this family are known to reduce coenzyme F420, a low-potential two-electron acceptor, as w... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR42845"
] | [
"Hydrogenase_assoc-protein"
] | [
3135
] | 1 | [] | [] | [] | 0 | [
"3zfs",
"4ci0",
"4omf",
"5odc",
"5odh",
"5odi",
"5odq",
"5odr",
"5xf9",
"5xfa",
"6qgr",
"6qgt",
"6qii",
"7t2r",
"7t30",
"9e15",
"9e1j",
"9nez",
"9nf0",
"9r51",
"9r52",
"9r5i",
"9r6z"
] | 23 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Podocopida",
"unclassified sequences"
] | [
598,
2391,
2,
144
] | 4 | [] | [] | 0 | true | Family | Hydrogenase complex-associated protein | Hydrogenase complex-associated protein | Hydrogenase_assoc-protein | 7 |
IPR051350 | 51,350 | WD repeat-containing signal transduction regulator | WD_repeat-ST_regulator | Family | 9,411 | true | false | This family of proteins is involved in various cellular processes including signal transduction, proteasomal degradation, cell growth and migration, and response to stress. Members act as scaffolding proteins, coordinating the activity of multiple signaling pathways such as MAPK, Wnt, and PI3K/AKT. They are implicated ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR22838"
] | [
"WD_repeat-ST_regulator"
] | [
9411
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-DME-9861718",
"R-DRE-9861718",
"R-HSA-9861718",
"R-MMU-9861718",
"R-RNO-9861718",
"R-SCE-9861718",
"R-SPO-9861718",
"R-XTR-9861718"
] | [
"REACTOME:R-DME-9861718",
"REACTOME:R-DRE-9861718",
"REACTOME:R-HSA-9861718",
"REACTOME:R-MMU-9861718",
"REACTOME:R-RNO-9861718",
"REACTOME:R-SCE-9861718",
"REACTOME:R-SPO-9861718",
"REACTOME:R-XTR-9861718"
] | 8 | [
"7nsb",
"8qbn",
"8qe8"
] | 3 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Megamimivirinae",
"Methanolobus tindarius DSM 2278",
"hydrothermal vent metagenome"
] | [
70,
9331,
7,
1,
2
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
13,
3,
4,
2,
16,
11,
1,
14,
9,
1,
1,
23
] | 12 | true | Family | WD repeat-containing signal transduction regulator | WD repeat-containing signal transduction regulator | WD_repeat-ST_regulator | 4 |
IPR051351 | 51,351 | Ascorbate-specific PTS system EIIA component | Ascorbate-PTS_EIIA_comp | Family | 8,341 | true | false | The ascorbate-specific PTS system EIIA component family is involved in the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), which is a key carbohydrate active transport system. Members of this family catalyze the phosphorylation of incoming sugar substrates while simultaneously translocating t... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR36203"
] | [
"Ascorbate-PTS_EIIA_comp"
] | [
8341
] | 1 | [] | [] | [] | 0 | [
"2oq3",
"2oqt",
"3bjv",
"3oxp"
] | 4 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Opisthokonta",
"metagenomes"
] | [
9,
8308,
3,
21
] | 4 | [
"Escherichia coli (strain K12)"
] | [
3
] | 1 | true | Family | Ascorbate-specific PTS system EIIA component | Ascorbate-specific PTS system EIIA component | Ascorbate-PTS_EIIA_comp | 8 |
IPR051353 | 51,353 | Tobamovirus Resistance UPF0261 | Tobamovirus_resist_UPF0261 | Family | 8,060 | true | false | The UPF0261 family includes proteins that function as inhibitors of viral RNA replication, conferring resistance to various tobamoviruses. Members of the family interfere with the replication process by disrupting the association of tobamovirus replication proteins with host membrane-associated proteins, thereby preven... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR31862"
] | [
"Tobamovirus_resist_UPF0261"
] | [
8060
] | 1 | [] | [] | [] | 0 | [
"2p10",
"3wrv",
"3wrw",
"3wrx",
"3wry",
"9mpy"
] | 6 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
182,
5406,
2399,
73
] | 4 | [
"Arabidopsis thaliana",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
7,
2,
3,
24
] | 4 | true | Family | Tobamovirus Resistance UPF0261 | Tobamovirus Resistance UPF0261 | Tobamovirus_resist_UPF0261 | 7 |
IPR051354 | 51,354 | Transposase 27 family, IS1 element | Transposase_27_IS1 | Family | 7,748 | true | false | The transposase 27 family is comprised of proteins that are essential for the transposition of the IS1 insertion element. Members of this family share a common function in facilitating the movement of the IS1 element within the genome, a process that can impact genetic variation and adaptation. These proteins are chara... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR33293"
] | [
"Transposase_27_IS1"
] | [
7748
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
617,
6818,
8,
9,
296
] | 5 | [
"Escherichia coli (strain K12)"
] | [
8
] | 1 | true | Family | Transposase 27 family, IS1 element | Transposase 27 family, IS1 element | Transposase_27_IS1 | 4 |
IPR051356 | 51,356 | SOX/SOX-like transcription factors | SOX/SOX-like_TF | Family | 9,512 | true | false | This family of proteins includes transcription factors that play crucial roles in developmental processes such as chondrocyte differentiation, cartilage formation, and neurogenesis. They are characterized by their ability to bind to a specific DNA motif, which is essential for the regulation of gene expression related ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR45789"
] | [
"SOX/SOX-like_TF"
] | [
9512
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-CEL-3769402",
"R-HSA-3769402",
"R-MMU-3769402",
"R-RNO-3769402",
"R-XTR-3769402"
] | [
"REACTOME:R-CEL-3769402",
"REACTOME:R-HSA-3769402",
"REACTOME:R-MMU-3769402",
"REACTOME:R-RNO-3769402",
"REACTOME:R-XTR-3769402"
] | 5 | [
"1i11"
] | 1 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
9512
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus"
] | [
3,
92,
3,
25,
21,
1,
19
] | 7 | true | Family | SOX/SOX-like transcription factors | SOX/SOX-like transcription factors | SOX/SOX-like_TF | 3 |
IPR051357 | 51,357 | Histone-lysine N-methyltransferase SUVAR3-9 | H3K9_HMTase_SUVAR3-9 | Family | 6,781 | true | false | This family of proteins includes histone-lysine N-methyltransferases, which are primarily involved in the methylation of 'Lys-9' of histone H3, a post-translational modification that is recognized as a marker for epigenetic transcriptional repression. These proteins contain SET domains that are responsible for their en... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR45660"
] | [
"H3K9_HMTase_SUVAR3-9"
] | [
6781
] | 1 | [
"EC"
] | [
"2.1.1"
] | [
"EC:2.1.1"
] | 1 | [
"3q0b",
"3q0c",
"3q0d",
"3q0f",
"4nj5",
"4qen",
"4qeo",
"4qep",
"4ygi",
"6a5k",
"6a5m",
"6a5n"
] | 12 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota"
] | [
41,
6740
] | 2 | [
"Arabidopsis thaliana",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
53,
1,
45,
69
] | 4 | true | Family | Histone-lysine N-methyltransferase SUVAR3-9 | Histone-lysine N-methyltransferase SUVAR3-9 | H3K9_HMTase_SUVAR3-9 | 7 |
IPR051358 | 51,358 | Transcription factor AMS/ICE1/BHLH6-like | TF_AMS/ICE1/BHLH6-like | Family | 9,738 | true | true | This entry includes bHLH transcription factors from plants that play diverse roles in plant development and responses. ICE1 is involved in regulating cold-induced transcription of CBF/DREB1 genes, and stomatal differentiation [ , ]. Transcription factor FIT is involved in iron acquisition [ ] while AMS (ABORTED MICROSP... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR31945"
] | [
"Plant_bHLH_TF"
] | [
9738
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00149185",
"PUB00149188",
"PUB00149695",
"PUB00155115",
"PUB00155116",
"PUB00155117"
] | [
"12535353",
"18641265",
"15539473",
"28507175",
"22456953",
"33128314"
] | [
"The Arabidopsis ABORTED MICROSPORES (AMS) gene encodes a MYC class transcription factor.",
"SCREAM/ICE1 and SCREAM2 specify three cell-state transitional steps leading to arabidopsis stomatal differentiation.",
"The essential basic helix-loop-helix protein FIT1 is required for the iron deficiency response.",
... | [
2003,
2008,
2004,
2017,
2013,
2021
] | 6 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
9738
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
70,
31,
94
] | 3 | true | Family | Transcription factor AMS/ICE1/BHLH6-like | Transcription factor AMS/ICE1/BHLH6-like | TF_AMS/ICE1/BHLH6-like | 7 |
IPR051359 | 51,359 | Calcium:cation antiporter | CaCA_antiporter | Family | 7,900 | true | false | This family of proteins includes membrane-localized transporters involved in the exchange of cations, particularly calcium, across cellular membranes. They function by mediating the efflux of calcium in exchange for sodium or lithium ions, which is crucial for maintaining calcium homeostasis within various organelles, ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR12266"
] | [
"CaCA_antiporter"
] | [
7900
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-CEL-425561",
"R-CEL-8949215",
"R-HSA-425561",
"R-HSA-8949215",
"R-MMU-425561",
"R-MMU-8949215",
"R-RNO-425561",
"R-RNO-8949215",
"R-SCE-425561",
"R-SCE-8949215",
"R-SPO-425561",
"R-SPO-8949215"
] | [
"REACTOME:R-CEL-425561",
"REACTOME:R-CEL-8949215",
"REACTOME:R-HSA-425561",
"REACTOME:R-HSA-8949215",
"REACTOME:R-MMU-425561",
"REACTOME:R-MMU-8949215",
"REACTOME:R-RNO-425561",
"REACTOME:R-RNO-8949215",
"REACTOME:R-SCE-425561",
"REACTOME:R-SCE-8949215",
"REACTOME:R-SPO-425561",
"REACTOME:R-SP... | 12 | [
"9ps1",
"9ps2",
"9ps3",
"9ps4",
"9ps6",
"9ps8"
] | 6 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
7900
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
20,
6,
2,
14,
8,
2,
1,
24,
6,
2,
1,
28
] | 12 | true | Family | Calcium:cation antiporter | Calcium:cation antiporter | CaCA_antiporter | 4 |
IPR051360 | 51,360 | Neuronal Pentraxin and Related | Neuronal_Pentraxin_Related | Family | 6,182 | true | false | This family of proteins includes members that are implicated in synaptic processes such as the uptake of synaptic material during synapse remodeling and the clustering of AMPA glutamate receptors at excitatory synapses. Some family members are thought to play a role in long-term plasticity and may bind to specific matr... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR19277"
] | [
"Neuronal_Pentraxin_Related"
] | [
6182
] | 1 | [] | [] | [] | 0 | [
"3flp",
"3flr",
"3flt",
"6ype",
"8b55"
] | 5 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"metagenomes"
] | [
9,
468,
5680,
2,
23
] | 5 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
23,
3,
9,
17,
10
] | 5 | true | Family | Neuronal Pentraxin and Related | Neuronal Pentraxin and Related | Neuronal_Pentraxin_Related | 4 |
IPR051361 | 51,361 | ThrE/Ser Exporter | ThrE/Ser_Exporter | Family | 5,855 | true | false | This family of proteins includes members that are involved in the transport of amino acids across cellular membranes. Specifically, they are associated with the export of threonine and serine from the cell to the extracellular environment. The transport mechanism is believed to be dependent on the proton motive force. ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR31082"
] | [
"ThrE/Ser_Exporter"
] | [
5855
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Methanobacteriota",
"metagenomes"
] | [
1880,
3933,
28,
14
] | 4 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
1,
2,
2
] | 3 | true | Family | ThrE/Ser Exporter | ThrE/Ser Exporter | ThrE/Ser_Exporter | 3 |
IPR051362 | 51,362 | WD repeat creC family regulators | WD_repeat_creC_regulators | Family | 6,876 | true | false | The WD repeat creC family is involved in the regulation of carbon source utilization and protein stability through ubiquitination and deubiquitination processes. Members of the family function as components of a regulatory network that includes creA, creB, creC, creD, and acrB. They are essential for preventing the pro... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR14107"
] | [
"WD_repeat_creC_regulators"
] | [
6876
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-CEL-5689880",
"R-DME-5689880",
"R-HSA-5689880",
"R-SPO-5689880"
] | [
"REACTOME:R-CEL-5689880",
"REACTOME:R-DME-5689880",
"REACTOME:R-HSA-5689880",
"REACTOME:R-SPO-5689880"
] | 4 | [
"5k19",
"5k1c",
"6jlq"
] | 3 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"bird metagenome"
] | [
6875,
1
] | 2 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Schizosaccharomyces pombe (stra... | [
15,
2,
4,
1,
18,
14,
2,
6,
15,
1,
34
] | 11 | true | Family | WD repeat creC family regulators | WD repeat creC family regulators | WD_repeat_creC_regulators | 8 |
IPR051363 | 51,363 | RIG-I-like Receptor (RLR) Helicase | RLR_Helicase | Family | 6,250 | true | false | The RLR helicase family plays a crucial role in the innate immune response to viral infections. Members of this family act as cytoplasmic sensors that detect viral nucleic acids, leading to the activation of antiviral signaling pathways. These pathways result in the production of type I interferons and pro-inflammatory... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR14074"
] | [
"RLR_Helicase"
] | [
6250
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-1169408",
"R-HSA-168928",
"R-HSA-5689880",
"R-HSA-5689896",
"R-HSA-8983711",
"R-HSA-918233",
"R-HSA-933541",
"R-HSA-933542",
"R-HSA-933543",
"R-HSA-936440",
"R-HSA-9692916",
"R-HSA-9705671",
"R-HSA-9833109",
"R-HSA-9833110",
"R-HSA-9909505",
"R-MMU-1169408",
"R-MMU-5689880",
... | [
"REACTOME:R-HSA-1169408",
"REACTOME:R-HSA-168928",
"REACTOME:R-HSA-5689880",
"REACTOME:R-HSA-5689896",
"REACTOME:R-HSA-8983711",
"REACTOME:R-HSA-918233",
"REACTOME:R-HSA-933541",
"REACTOME:R-HSA-933542",
"REACTOME:R-HSA-933543",
"REACTOME:R-HSA-936440",
"REACTOME:R-HSA-9692916",
"REACTOME:R-HS... | 21 | [
"2qfb",
"2qfd",
"2rmj",
"2rqa",
"2rqb",
"2w4r",
"2ykg",
"3b6e",
"3eqt",
"3ga3",
"3lrn",
"3lrr",
"3ncu",
"3og8",
"3tbk",
"3ts9",
"3zd6",
"3zd7",
"4a2p",
"4a2q",
"4a2v",
"4a2w",
"4a2x",
"4a36",
"4ay2",
"4bpb",
"4gl2",
"4i1s",
"4on9",
"5e3h",
"5f98",
"5f9f"... | 89 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"ecological metagenomes"
] | [
18,
12,
6216,
4
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Zea mays"
] | [
2,
3,
4,
28,
19,
3,
11,
7,
19
] | 9 | true | Family | RIG-I-like Receptor (RLR) Helicase | RIG-I-like Receptor (RLR) Helicase | RLR_Helicase | 3 |
IPR051364 | 51,364 | Cytokinesis and Rho signaling-related protein | Cytokinesis/Rho-signaling | Family | 6,588 | true | false | This family of proteins is involved in various cellular processes, including cytokinesis, the final step of cell division where the cell splits into two. Members of this family are essential for the structural integrity of the cleavage furrow, which is the indentation that begins the process of division, and for the co... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR21538"
] | [
"Cytokinesis/Rho-signaling"
] | [
6588
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-CEL-8980692",
"R-CEL-9013026",
"R-DME-8980692",
"R-DME-9013026",
"R-HSA-5666185",
"R-HSA-8980692",
"R-HSA-9013026",
"R-HSA-9013106",
"R-MMU-5666185",
"R-MMU-8980692",
"R-MMU-9013026",
"R-MMU-9013106",
"R-RNO-5666185",
"R-RNO-8980692",
"R-RNO-9013026"
] | [
"REACTOME:R-CEL-8980692",
"REACTOME:R-CEL-9013026",
"REACTOME:R-DME-8980692",
"REACTOME:R-DME-9013026",
"REACTOME:R-HSA-5666185",
"REACTOME:R-HSA-8980692",
"REACTOME:R-HSA-9013026",
"REACTOME:R-HSA-9013106",
"REACTOME:R-MMU-5666185",
"REACTOME:R-MMU-8980692",
"REACTOME:R-MMU-9013026",
"REACTOM... | 15 | [
"2y7b",
"4xh3",
"4xoi"
] | 3 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"bird metagenome"
] | [
6587,
1
] | 2 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
7,
21,
4,
10,
13,
21
] | 6 | true | Family | Cytokinesis and Rho signaling-related protein | Cytokinesis and Rho signaling-related protein | Cytokinesis/Rho-signaling | 9 |
IPR051365 | 51,365 | TOX high mobility group box domain-containing protein | TOX_HMG-box_domain | Family | 6,316 | true | false | This family of proteins includes transcriptional regulators and coactivators that play crucial roles in various biological processes such as neural stem cell commitment, corticogenesis, lymphoid cell development, and organogenesis. Members of this family are known to bind to GC-rich DNA sequences, potentially altering ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR45781"
] | [
"TOX_HMG-box_domain"
] | [
6316
] | 1 | [] | [] | [] | 0 | [
"2co9",
"9ci7"
] | 2 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Metazoa",
"bird metagenome"
] | [
6315,
1
] | 2 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
25,
2,
17,
13,
27
] | 6 | true | Family | TOX high mobility group box domain-containing protein | TOX high mobility group box domain-containing protein | TOX_HMG-box_domain | 7 |
IPR051366 | 51,366 | Differentially Expressed in FDCP 8 Homolog | DEF8 | Family | 5,536 | true | false | The DEF8 family is involved in various cellular processes related to the endolysosomal system, autophagy, and bone resorption. Members of the family act as multivalent adapter proteins that regulate fusion events between late endosomes and lysosomes, which are essential for the maturation of endolysosomal compartments.... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR12326"
] | [
"DEF8"
] | [
5536
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
5536
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
7,
6,
17,
4,
19,
11,
11
] | 7 | true | Family | Differentially Expressed in FDCP 8 Homolog | Differentially Expressed in FDCP 8 Homolog | DEF8 | 3 |
IPR051368 | 51,368 | Serine Protease Inhibitor-like TIL Domain | SerProtInhib-TIL_Domain | Family | 4,548 | true | false | The serine protease inhibitor-like (TIL domain-containing) family comprises a diverse group of proteins that primarily function to inhibit serine proteases, defending the organism against host proteinases. Members of this family have been identified with various specific inhibitory activities, including chymotrypsin, c... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR23259"
] | [
"SerProtInhib-TIL_Domain"
] | [
4548
] | 1 | [] | [] | [] | 0 | [
"1ccv",
"2p3f",
"8hwu",
"8j3q"
] | 4 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Chloriridovirus",
"Eukaryota",
"Nocardia colli"
] | [
3,
4544,
1
] | 3 | [
"Caenorhabditis elegans",
"Drosophila melanogaster"
] | [
31,
3
] | 2 | true | Family | Serine Protease Inhibitor-like TIL Domain | Serine Protease Inhibitor-like TIL Domain | SerProtInhib-TIL_Domain | 6 |
IPR051369 | 51,369 | Glutathione S-transferase Theta | GST_Theta | Family | 4,378 | true | false | This family of proteins is involved in the detoxification process by conjugating reduced glutathione to a variety of exogenous and endogenous hydrophobic electrophiles. Members of this family exhibit a range of activities, including sulfatase activity and the ability to bind to various substances such as steroids, bili... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR43917"
] | [
"GST_Theta"
] | [
4378
] | 1 | [
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"2.5.1.18",
"PWY-4061",
"PWY-6842",
"PWY-7112",
"PWY-7533",
"R-BTA-156590",
"R-BTA-9753281",
"R-GGA-156590",
"R-HSA-156590",
"R-HSA-9753281",
"R-MMU-156590",
"R-MMU-9753281",
"R-RNO-156590",
"R-RNO-9753281"
] | [
"EC:2.5.1.18",
"METACYC:PWY-4061",
"METACYC:PWY-6842",
"METACYC:PWY-7112",
"METACYC:PWY-7533",
"REACTOME:R-BTA-156590",
"REACTOME:R-BTA-9753281",
"REACTOME:R-GGA-156590",
"REACTOME:R-HSA-156590",
"REACTOME:R-HSA-9753281",
"REACTOME:R-MMU-156590",
"REACTOME:R-MMU-9753281",
"REACTOME:R-RNO-156... | 14 | [
"1ljr",
"2c3n",
"2c3q",
"2c3t",
"2ljr",
"3ljr",
"4mpf",
"4mpg"
] | 8 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
149,
4225,
4
] | 3 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
4,
15,
28,
14,
20
] | 5 | true | Family | Glutathione S-transferase Theta | Glutathione S-transferase Theta | GST_Theta | 2 |
IPR051370 | 51,370 | Peptidyl-prolyl cis-trans isomerase Pin1 | PPIase_Pin1 | Family | 4,709 | true | true | The Pin1 family of peptidyl-prolyl cis-trans isomerases (PPIases) is involved in the isomerization of specific phosphorylated Ser/Thr-Pro motifs, acting as molecular switches in various cellular processes [ , . Members of this family display a preference for acidic residues N-terminal to the proline bond to be isomeriz... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR10657"
] | [
"PPIase_Pin1"
] | [
4709
] | 1 | [
"EC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"5.2.1.8",
"R-BTA-5668599",
"R-BTA-6804756",
"R-BTA-6811555",
"R-BTA-936440",
"R-DME-6804756",
"R-DME-6811555",
"R-HSA-1169408",
"R-HSA-5668599",
"R-HSA-6804756",
"R-HSA-6811555",
"R-HSA-936440",
"R-MMU-5668599",
"R-MMU-6804756",
"R-MMU-6811555",
"R-MMU-936440",
"R-SCE-5668599",
"R... | [
"EC:5.2.1.8",
"REACTOME:R-BTA-5668599",
"REACTOME:R-BTA-6804756",
"REACTOME:R-BTA-6811555",
"REACTOME:R-BTA-936440",
"REACTOME:R-DME-6804756",
"REACTOME:R-DME-6811555",
"REACTOME:R-HSA-1169408",
"REACTOME:R-HSA-5668599",
"REACTOME:R-HSA-6804756",
"REACTOME:R-HSA-6811555",
"REACTOME:R-HSA-93644... | 20 | [
"1f8a",
"1j6y",
"1nmv",
"1nmw",
"1pin",
"1yw5",
"1zcn",
"2f21",
"2itk",
"2lj4",
"2n87",
"2q5a",
"2ruc",
"2rud",
"2ruq",
"2rur",
"2xp3",
"2xp4",
"2xp5",
"2xp6",
"2xp7",
"2xp8",
"2xp9",
"2xpa",
"2xpb",
"2zqs",
"2zqt",
"2zqu",
"2zqv",
"2zr4",
"2zr5",
"2zr6"... | 132 | [
"PUB00155190",
"PUB00155191",
"PUB00155192"
] | [
"16644721",
"23623683",
"29686383"
] | [
"Regulation of Bruton tyrosine kinase by the peptidylprolyl isomerase Pin1.",
"Prolyl isomerase PIN1 regulates DNA double-strand break repair by counteracting DNA end resection.",
"The IL-33-PIN1-IRAK-M axis is critical for type 2 immunity in IL-33-induced allergic airway inflammation."
] | [
2006,
2013,
2018
] | 3 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Candidatus Nanohalococcus occultus",
"Eukaryota",
"unclassified sequences"
] | [
134,
1,
4570,
4
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
3,
1,
1,
3,
5,
3,
1,
6,
4,
1,
1,
6
] | 12 | true | Family | Peptidyl-prolyl cis-trans isomerase Pin1 | Peptidyl-prolyl cis-trans isomerase Pin1 | PPIase_Pin1 | 7 |
IPR051371 | 51,371 | Ras-specific palmitoyltransferase complex | Ras_palmitoyltransferase | Family | 4,631 | true | false | This family of proteins includes palmitoyltransferases that are involved in the post-translational modification of Ras proteins, which is crucial for their proper localization to the plasma membrane and subsequent function in cell signaling. Members of this family form complexes, such as ERF2-ERF4 in yeast and ZDHHC9-G... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR13254"
] | [
"Ras_palmitoyltransferase"
] | [
4631
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-6798695",
"R-BTA-9648002",
"R-HSA-6798695",
"R-HSA-9648002",
"R-HSA-9694548",
"R-MMU-6798695",
"R-MMU-9648002",
"R-RNO-6798695",
"R-RNO-9648002",
"R-SCE-6798695",
"R-SPO-6798695"
] | [
"REACTOME:R-BTA-6798695",
"REACTOME:R-BTA-9648002",
"REACTOME:R-HSA-6798695",
"REACTOME:R-HSA-9648002",
"REACTOME:R-HSA-9694548",
"REACTOME:R-MMU-6798695",
"REACTOME:R-MMU-9648002",
"REACTOME:R-RNO-6798695",
"REACTOME:R-RNO-9648002",
"REACTOME:R-SCE-6798695",
"REACTOME:R-SPO-6798695"
] | 11 | [
"8hf3",
"8hfc",
"9oa6"
] | 3 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
4631
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strai... | [
2,
4,
2,
8,
2,
1,
9,
1,
1
] | 9 | true | Family | Ras-specific palmitoyltransferase complex | Ras-specific palmitoyltransferase complex | Ras_palmitoyltransferase | 2 |
IPR051372 | 51,372 | Pre-mRNA-splicing factor CWC21 | CWC21 | Family | 4,741 | true | false | This family of proteins is involved in the process of pre-mRNA splicing. Members of this family are thought to act at or before the first catalytic step in the spliceosome, potentially by stabilizing the catalytic center or the RNA substrate's position. Some members may also interact with RNA polymerase II, influencing... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR36562"
] | [
"CWC21"
] | [
4741
] | 1 | [
"REACTOME"
] | [
"R-HSA-72163"
] | [
"REACTOME:R-HSA-72163"
] | 1 | [
"5gm6",
"5gmk",
"5lj3",
"5lj5",
"5mps",
"5mq0",
"5mqf",
"5wsg",
"5xjc",
"5ylz",
"5yzg",
"5z56",
"5z57",
"6bk8",
"6exn",
"6ff4",
"6ff7",
"6icz",
"6j6g",
"6j6h",
"6j6n",
"6j6q",
"6qdv",
"6zym",
"7a5p",
"7b9v",
"7dco",
"7dvq",
"7qtt",
"7w59",
"7w5a",
"7w5b"... | 47 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Mimiviridae",
"viral metagenome"
] | [
3,
4732,
5,
1
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S2... | [
4,
1,
2,
22,
5,
1,
5,
1,
1,
1,
31
] | 11 | true | Family | Pre-mRNA-splicing factor CWC21 | Pre-mRNA-splicing factor CWC21 | CWC21 | 1 |
IPR051374 | 51,374 | Ataxin-10 and Copper transport protein 86 families | Ataxin-10/CTR86_families | Family | 4,358 | true | false | The Ataxin-10 family proteins are essential for the survival and maintenance of cerebellar neurons. They are involved in neuritogenesis through the activation of the Ras-MAP kinase pathway. Additionally, they may contribute to the regulation of intracellular glycosylation levels and homeostasis. The Copper transport pr... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR13255"
] | [
"Ataxin-10/CTR86_families"
] | [
4358
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
4358
] | 1 | [
"Arabidopsis thaliana",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"... | [
4,
3,
2,
5,
4,
1,
2,
4,
1,
1,
2
] | 11 | true | Family | Ataxin-10 and Copper transport protein 86 families | Ataxin-10 and Copper transport protein 86 families | Ataxin-10/CTR86_families | 1 |
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