LiteFold/InterPro · Datasets at Hugging Face

IPR005154

5,154

Alpha glucuronidase, N-terminal

Glyco_hydro_67_aGlcAse_N

Domain

3,287

false

O-Glycosyl hydrolases ( ) are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycosyl hydrolases, based on sequence similarity, has led to the definition of 85 different families [ ,...

[ "GO:0046559", "GO:0045493" ]

[ "alpha-glucuronidase activity", "xylan catabolic process" ]

[ "molecular_function", "biological_process" ]

2

[ "PFAM" ]

[ "PF03648" ]

[ "Glyco_hydro_67N" ]

[ 3287 ]

1

[ "CAZY", "EC" ]

[ "GH67", "3.2.1.139" ]

[ "CAZY:GH67", "EC:3.2.1.139" ]

2

[ "1gqi", "1gqj", "1gqk", "1gql", "1h41", "1k9d", "1k9e", "1k9f", "1l8n", "1mqp", "1mqq", "1mqr" ]

12

[ "PUB00004870", "PUB00005266", "PUB00008353" ]

[ "7624375", "8535779", "11358519" ]

[ "Conserved catalytic machinery and the prediction of a common fold for several families of glycosyl hydrolases.", "Structures and mechanisms of glycosyl hydrolases.", "Biochemical characterization and identification of catalytic residues in alpha-glucuronidase from Bacillus stearothermophilus T-6." ]

[ 1995, 1995, 2001 ]

3

[]

0

null

[ "Bacteria", "Eukaryota", "Halobacteriales", "unclassified sequences" ]

[ 2363, 859, 44, 21 ]

4

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)" ]

[ 1 ]

1

true

Domain

Alpha glucuronidase, N-terminal

Glyco_hydro_67_aGlcAse_N

5

IPR005155

5,155

UPF0113, PUA domain

UPF0113_PUA

Domain

4,719

false

This entry represents the PUA (PseudoUridine synthase and Archaeosine transglycosylase) domain found in 60S ribosome subunit biogenesis protein NIP7, some UPF0113 family members, such as KD93, and similar proteins found in eukaryotes and some archaeal species [ , , ]. PUA domains are predicted to bind RNA molecules wit...

[]

0

[ "PFAM", "CDD" ]

[ "PF03657", "cd21151" ]

[ "UPF0113", "PUA_Nip7-like" ]

[ 4490, 4627 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-6791226", "R-MMU-6791226", "R-RNO-6791226", "R-SSC-6791226" ]

[ "REACTOME:R-HSA-6791226", "REACTOME:R-MMU-6791226", "REACTOME:R-RNO-6791226", "REACTOME:R-SSC-6791226" ]

4

[ "1sqw", "1t5y", "2p38", "3m4x", "6elz", "6em5", "7nac", "7ohr", "7r6k", "7r7a", "7r7c", "8esq", "8esr", "8fkt", "8fku", "8fkv", "8fkw", "8fkx", "8fky", "8i9r", "8i9t", "8i9v", "8i9w", "8i9x", "8i9y", "8i9z", "8ia0", "8v83", "8v84", "8v87" ]

30

[ "PUB00003444", "PUB00017206", "PUB00017207", "PUB00026235", "PUB00031177", "PUB00036066", "PUB00049350" ]

[ "10093218", "9271378", "9891085", "12732145", "15522784", "16943774", "18059286" ]

[ "Novel predicted RNA-binding domains associated with the translation machinery.", "Saccharomyces cerevisiae Nip7p is required for efficient 60S ribosome subunit biogenesis.", "Nip7p interacts with Nop8p, an essential nucleolar protein required for 60S ribosome biogenesis, and the exosome subunit Rrp43p.", "Al...

[ 1999, 1997, 1999, 2003, 2004, 2006, 2007 ]

7

[ "IPR002478" ]

[]

1

0

1

[ "Archaea", "Bacteria", "Eukaryota", "marine sediment metagenome" ]

[ 185, 31, 4491, 12 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 5, 1, 2, 1, 4, 2, 1, 3, 3, 1, 1, 2 ]

12

true

Domain

UPF0113, PUA domain

UPF0113_PUA

9

IPR005158

5,158

Bacterial transcriptional activator domain

BTAD

Domain

47,730

false

Found in the DNRI/REDD/AFSR family of regulators, this domain of AFSR ( ) along with the C-terminal region is capable of independently directing actinorhodin production. AFSR is important for the formation of secondary metabolites [ ].

[]

0

[ "PFAM", "SMART", "CDD" ]

[ "PF03704", "SM01043", "cd15831" ]

[ "BTAD", "BTAD", "BTAD" ]

[ 46235, 46270, 31826 ]

3

[]

0

[ "2fez", "2ff4", "8hvr", "8jke", "8k60" ]

5

[ "PUB00056879" ]

[ "2253887" ]

[ "Primary structure of AfsR, a global regulatory protein for secondary metabolite formation in Streptomyces coelicolor A3(2)." ]

[ 1990 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "Methanomicrobia", "unclassified sequences" ]

[ 47345, 238, 12, 135 ]

4

[]

0

true

Domain

Bacterial transcriptional activator domain

BTAD

2

IPR005159

5,159

WCCH motif

WCCH

Domain

2,640

false

The WCCH motif is found in a retrotransposons and Gemini viruses. A specific function has not been associated to this motif [ ].

[]

0

[ "PFAM" ]

[ "PF03716" ]

[ "WCCH" ]

[ 2640 ]

1

[]

0

[]

0

[ "PUB00008354" ]

[ "11600699" ]

[ "Pyret, a Ty3/Gypsy retrotransposon in Magnaporthe grisea contains an extra domain between the nucleocapsid and protease domains." ]

[ 2001 ]

1

[]

0

null

[ "Eukaryota", "Viruses" ]

[ 37, 2603 ]

2

[ "Arabidopsis thaliana" ]

[ 6 ]

1

true

Domain

WCCH motif

WCCH

4

IPR005160

5,160

Ku70/Ku80 C-terminal arm

Ku_C

Domain

6,263

false

The Ku heterodimer (composed of Ku70 and Ku80 ) contributes to genomic integrity through its ability to bind DNA double-strand breaks and facilitate repair by the non-homologous end-joining pathway. This is the C-terminal arm. This α helical region embraces the β-barrel domain of the opposite subunit [ ].

[ "GO:0003677", "GO:0003678", "GO:0006303" ]

[ "DNA binding", "DNA helicase activity", "double-strand break repair via nonhomologous end joining" ]

[ "molecular_function", "molecular_function", "biological_process" ]

3

[ "PFAM" ]

[ "PF03730" ]

[ "Ku_C" ]

[ 6263 ]

1

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "3.6.4.12", "R-DDI-5693571", "R-DDI-6798695", "R-DME-6798695", "R-GGA-353423", "R-HSA-164843", "R-HSA-1834949", "R-HSA-3270619", "R-HSA-5693571", "R-HSA-6798695", "R-MMU-5693571", "R-MMU-6798695", "R-SCE-6798695", "R-SPO-6798695" ]

[ "EC:3.6.4.12", "REACTOME:R-DDI-5693571", "REACTOME:R-DDI-6798695", "REACTOME:R-DME-6798695", "REACTOME:R-GGA-353423", "REACTOME:R-HSA-164843", "REACTOME:R-HSA-1834949", "REACTOME:R-HSA-3270619", "REACTOME:R-HSA-5693571", "REACTOME:R-HSA-6798695", "REACTOME:R-MMU-5693571", "REACTOME:R-MMU-67986...

14

[ "1jeq", "1jey", "5y3r", "5y58", "6erf", "6erg", "6erh", "6zha", "6zhe", "7axz", "7k0y", "7k1j", "7k1k", "7k1n", "7lsy", "7lt3", "7nfc", "7nfe", "7sgl", "7su3", "7sud", "7z6o", "7z87", "7z88", "7zt6", "7zvt", "7zwa", "7zyg", "8ag4", "8ag5", "8asc", "8bh3"...

50

[ "PUB00007947" ]

[ "11493912" ]

[ "Structure of the Ku heterodimer bound to DNA and its implications for double-strand break repair." ]

[ 2001 ]

1

[]

0

null

[ "Eukaryota", "Helicobacter typhlonius" ]

[ 6262, 1 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 9, 1, 8, 12, 9, 4, 1, 2, 11, 1, 1, 13 ]

12

true

Domain

Ku70/Ku80 C-terminal arm

Ku_C

5

IPR005161

5,161

Ku70/Ku80, N-terminal alpha/beta

Ku_N

Domain

8,893

false

The Ku heterodimer (composed of Ku70 and Ku80 ) contributes to genomic integrity through its ability to bind DNA double-strand breaks and facilitate repair by the non-homologous end-joining pathway. This is the N-terminal α/β domain. This domain only makes a small contribution to the dimer interface. The domain compris...

[]

0

[ "PFAM" ]

[ "PF03731" ]

[ "Ku_N" ]

[ 8893 ]

1

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "3.6.4.12", "R-DDI-5693571", "R-DDI-6798695", "R-DME-6798695", "R-GGA-353423", "R-HSA-164843", "R-HSA-1834949", "R-HSA-3270619", "R-HSA-5693571", "R-HSA-6798695", "R-MMU-5693571", "R-MMU-6798695", "R-SCE-6798695", "R-SPO-6798695" ]

[ "EC:3.6.4.12", "REACTOME:R-DDI-5693571", "REACTOME:R-DDI-6798695", "REACTOME:R-DME-6798695", "REACTOME:R-GGA-353423", "REACTOME:R-HSA-164843", "REACTOME:R-HSA-1834949", "REACTOME:R-HSA-3270619", "REACTOME:R-HSA-5693571", "REACTOME:R-HSA-6798695", "REACTOME:R-MMU-5693571", "REACTOME:R-MMU-67986...

14

[ "1jeq", "1jey", "5y3r", "5y58", "5y59", "6erf", "6erg", "6erh", "6tyt", "6tyu", "6tyv", "6tyw", "6tyx", "6tyz", "6zha", "6zhe", "7axz", "7k0y", "7k1j", "7k1k", "7k1n", "7lsy", "7lt3", "7nfc", "7nfe", "7sgl", "7su3", "7sud", "7z6o", "7z87", "7z88", "7zt6"...

57

[ "PUB00008360" ]

[ "10191092" ]

[ "A novel testis-specific metallothionein-like protein, tesmin, is an early marker of male germ cell differentiation." ]

[ 1999 ]

1

[]

0

null

[ "Eukaryota" ]

[ 8893 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 9, 1, 8, 38, 9, 7, 2, 7, 12, 2, 1, 21 ]

12

true

Domain

Ku70/Ku80, N-terminal alpha/beta

Ku_N

1

IPR005162

5,162

Retrotransposon-derived protein PEG10, N-terminal capsid-like domain

PEG10_N-capsid-like

Domain

107,353

false

Transposable elements (TEs) promote various chromosomal rearrangements more efficiently, and often more specifically, than other cellular processes. Retrotransposons are structurally similar to retroviruses and are bounded by long terminal repeats. This entry represents eukaryotic Gag or capsid-related retrotranspon-re...

[]

0

[ "PFAM" ]

[ "PF03732" ]

[ "Retrotrans_gag" ]

[ 107353 ]

1

[]

0

[ "6s7x", "6s7y", "7lga" ]

3

[ "PUB00008354", "PUB00101192", "PUB00101193" ]

[ "11600699", "34413232", "30951545" ]

[ "Pyret, a Ty3/Gypsy retrotransposon in Magnaporthe grisea contains an extra domain between the nucleocapsid and protease domains.", "Mammalian retrovirus-like protein PEG10 packages its own mRNA and can be pseudotyped for mRNA delivery.", "The Gag protein PEG10 binds to RNA and regulates trophoblast stem cell l...

[ 2001, 2021, 2019 ]

3

[]

0

null

[ "Bacteria", "Cladosporium fulvum T-1 virus", "Eukaryota", "invertebrate metagenome" ]

[ 37, 1, 107312, 3 ]

4

[ "Arabidopsis thaliana", "Danio rerio", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 178, 3, 1, 1785, 1, 35 ]

6

true

Domain

Retrotransposon-derived protein PEG10, N-terminal capsid-like domain

PEG10_N-capsid-like

3

IPR005163

5,163

YiiM-like, triple helical domain

Tri_helical_YiiM-like

Domain

5,977

false

This small triple helical domain has been predicted to assume a topology similar to helix-turn-helix domains. These domains are found at the C-terminal of proteins related to the YiiM protein ( ) from Escherichia coli [ , ].

[]

0

[ "PFAM" ]

[ "PF03475" ]

[ "YiiM_3-alpha" ]

[ 5977 ]

1

[]

0

[ "1o65", "1o67", "5yhh", "5yhi" ]

4

[ "PUB00019067", "PUB00100687" ]

[ "11886751", "29459651" ]

[ "MOSC domains: ancient, predicted sulfur-carrier domains, present in diverse metal-sulfur cluster biosynthesis proteins including Molybdenum cofactor sulfurases.", "Crystal structure of the hydroxylaminopurine resistance protein, YiiM, and its putative molybdenum cofactor-binding catalytic site." ]

[ 2002, 2018 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "Halobacteriales", "metagenomes" ]

[ 5415, 548, 6, 8 ]

4

[ "Escherichia coli (strain K12)", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)" ]

[ 1, 1 ]

2

true

Domain

YiiM-like, triple helical domain

Tri_helical_YiiM-like

8

IPR005164

5,164

Allantoicase

Family

7,291

false

Allantoicase (also known as allantoate amidinohydrolase) is involved in purine degradation, facilitating the utilization of purines as secondary nitrogen sources under nitrogen-limiting conditions. While purine degradation converges to uric acid in all vertebrates, its further degradation varies from species to species...

[ "GO:0004037", "GO:0000256" ]

[ "allantoicase activity", "allantoin catabolic process" ]

[ "molecular_function", "biological_process" ]

2

[ "HAMAP", "PIRSF", "PANTHER", "NCBIFAM" ]

[ "MF_00813", "PIRSF016516", "PTHR12045", "TIGR02961" ]

[ "Allantoicase", "Allantoicase", "", "allantoicase" ]

[ 6520, 5469, 7166, 6642 ]

4

[ "EC", "GP", "GP", "GP", "GP", "METACYC" ]

[ "3.5.3.4", "GenProp0686", "GenProp0687", "GenProp1257", "GenProp1501", "PWY-5697" ]

[ "EC:3.5.3.4", "GP:GenProp0686", "GP:GenProp0687", "GP:GenProp1257", "GP:GenProp1501", "METACYC:PWY-5697" ]

6

[ "1o59", "1sg3" ]

2

[ "PUB00029326", "PUB00031044", "PUB00053905", "PUB00100275" ]

[ "15229895", "15020593", "11054555", "12036579" ]

[ "Crystal structure of an allantoicase (YIR029W) from Saccharomyces cerevisiae at 2.4 A resolution.", "Crystal structure of yeast allantoicase reveals a repeated jelly roll motif.", "Human allantoicase gene: cDNA cloning, genomic organization and chromosome localization.", "Genomic organization and chromosome ...

[ 2004, 2004, 2000, 2002 ]

4

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 4344, 2899, 48 ]

3

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 3, 1, 2, 1, 2, 1, 1 ]

7

true

Family

Allantoicase

5

IPR005165

5,165

Anthrax toxin, edema factor, central

Anthrax_toxin_edema_cen

Domain

504

false

Anthrax toxin is a plasmid-encoded toxin complex produced by the Gram-positive, spore-forming bacteria, Bacillus anthracis. The toxin consists of three non-toxic proteins: the protective antigen (PA), the lethal factor (LF) and the edema factor (EF) [ ]. These component proteins self-assemble at the surface of host cel...

[ "GO:0008294", "GO:0005576" ]

[ "calcium- and calmodulin-responsive adenylate cyclase activity", "extracellular region" ]

[ "molecular_function", "cellular_component" ]

2

[ "PFAM" ]

[ "PF03497" ]

[ "Anthrax_toxA" ]

[ 504 ]

1

[ "EC", "REACTOME" ]

[ "4.6.1.1", "R-HSA-5210891" ]

[ "EC:4.6.1.1", "REACTOME:R-HSA-5210891" ]

2

[ "1k8t", "1k90", "1k93", "1lvc", "1pk0", "1s26", "1sk6", "1xfu", "1xfv", "1xfw", "1xfx", "1xfy", "1xfz", "1y0v", "1yrt", "1yru", "1zot", "2col", "5xnw", "6uzb", "6uzd", "6uze", "6vra", "7p1g", "7p1h", "8bjh", "8bji", "8bjj", "8bo1", "8br0", "8br1" ]

31

[ "PUB00026280", "PUB00031089", "PUB00035784", "PUB00035785", "PUB00035786", "PUB00035787" ]

[ "11700563", "15131111", "14570563", "17335404", "17381430", "14616089" ]

[ "Crystal structure of the anthrax lethal factor.", "Structural and kinetic analyses of the interaction of anthrax adenylyl cyclase toxin with reaction products cAMP and pyrophosphate.", "Anthrax toxin.", "Anthrax toxin: receptor binding, internalization, pore formation, and translocation.", "Characterizatio...

[ 2001, 2004, 2003, 2007, 2007, 2004 ]

6

[]

0

null

[ "Bacteria", "Eukaryota", "bioreactor metagenome" ]

[ 365, 138, 1 ]

3

[]

0

true

Domain

Anthrax toxin, edema factor, central

Anthrax_toxin_edema_cen

4

IPR005166

5,166

Rous sarcoma virus, Gp95, envelope protein

RSV_p95_env

Family

1,197

false

A family of a vain specific viral glycoproteins that forms a receptor-binding Gp95 polypeptide that is linked through disulphide to a membrane-spanning gp37 spike. Gp95 confers a high degree of subgroup specificity for interaction with distinct cell receptors [ ].

[]

0

[ "PFAM" ]

[ "PF03708" ]

[ "Avian_gp85" ]

[ 1197 ]

1

[]

0

[]

0

[ "PUB00008358" ]

[ "3009025" ]

[ "Determinants for receptor interaction and cell killing on the avian retrovirus glycoprotein gp85." ]

[ 1986 ]

1

[]

0

null

[ "Retroviridae", "Sauria" ]

[ 898, 299 ]

2

[]

0

true

Family

Rous sarcoma virus, Gp95, envelope protein

RSV_p95_env

9

IPR005167

5,167

Bunyavirus glycoprotein G1

Bunya_G1

Domain

1,527

false

Bunyavirus has three genomic segments: small (S), middle-sized (M), and large (L). The S segment encodes the nucleocapsid and a non-structural protein. The M segment codes for two glycoproteins, G1 (also known as Gc) and G2 (also known as G2), and another non-structural protein (NSm). The L segment codes for an RNA pol...

[ "GO:0044003" ]

[ "symbiont-mediated perturbation of host process" ]

[ "biological_process" ]

1

[ "PFAM" ]

[ "PF03557" ]

[ "Bunya_G1" ]

[ 1527 ]

1

[ "GP" ]

[ "GenProp1007" ]

[ "GP:GenProp1007" ]

1

[ "6h3s", "6h3t", "6h3u", "6h3v", "6h3w", "6h3x", "7a56", "7a57" ]

8

[ "PUB00008359", "PUB00019235", "PUB00100093" ]

[ "8553534", "8918555", "30787296" ]

[ "Tropism of bunyaviruses: evidence for a G1 glycoprotein-mediated entry pathway common to the California serogroup.", "The extracellular domain of La Crosse virus G1 forms oligomers and undergoes pH-dependent conformational changes.", "Orthobunyavirus spike architecture and recognition by neutralizing antibodie...

[ 1995, 1996, 2019 ]

3

[]

0

null

[ "Viruses" ]

[ 1527 ]

1

[]

0

true

Domain

Bunyavirus glycoprotein G1

Bunya_G1

4

IPR005168

5,168

Bunyavirus glycoprotein G2

Bunya_G2

Domain

1,202

false

Bunyavirus has three genomic segments: small (S), middle-sized (M), and large (L). The S segment encodes the nucleocapsid and a non-structural protein. The M segment codes for two glycoproteins, G1 and G2, and another non-structural protein (NSm). The L segment codes for an RNA polymerase. This entry represents the pol...

[]

0

[ "PFAM" ]

[ "PF03563" ]

[ "Bunya_G2" ]

[ 1202 ]

1

[ "GP" ]

[ "GenProp1007" ]

[ "GP:GenProp1007" ]

1

[]

0

[ "PUB00009407" ]

[ "7645217" ]

[ "Homodimeric association of the spike glycoproteins G1 and G2 of Uukuniemi virus." ]

[ 1995 ]

1

[]

0

null

[ "Prochlorococcus marinus str. GP2", "Viruses" ]

[ 1, 1201 ]

2

[]

0

true

Domain

Bunyavirus glycoprotein G2

Bunya_G2

6

IPR005169

5,169

CagA exotoxin, phosphopeptide substrate mimic region

CagA_C

Domain

3,090

false

Helicobacter pylori is the most common world-wide infection and plays an important role in pathogenesis of peptic ulcers. The CagA (cytotoxin-associated gene A) protein is a cell-surface antigen which may play a role in determining the relative virulence of the viral strains. This entry represents the phosphopeptide su...

[]

0

[ "PFAM" ]

[ "PF03507" ]

[ "CagA" ]

[ 3090 ]

1

[]

0

[ "3iec" ]

1

[ "PUB00054763" ]

[ "19966800" ]

[ "Helicobacter pylori CagA inhibits PAR1-MARK family kinases by mimicking host substrates." ]

[ 2010 ]

1

[]

0

null

[ "Bacteria" ]

[ 3090 ]

1

[]

0

true

Domain

CagA exotoxin, phosphopeptide substrate mimic region

CagA_C

3

IPR005170

5,170

Transporter-associated domain

Transptr-assoc_dom

Domain

68,009

false

This small domain is found in a family of proteins with the CBS domain and two CBS domains with this domain found at the C-terminal of the proteins, the domain is also found at the C-terminal of some Na + /H + antiporters [ ]. This domain is also found in CorC that is involved in Magnesium and cobalt efflux [ ]. The fu...

[]

0

[ "PFAM", "SMART" ]

[ "PF03471", "SM01091" ]

[ "CorC_HlyC", "CorC_HlyC" ]

[ 67540, 67658 ]

2

[]

0

[ "2nqw", "2o3g", "2oai", "2p13", "2p3h", "2p4p", "2pli", "2pls", "2r2z", "2r8d", "2rk5", "3ded", "3lae", "3llb", "4hg0" ]

15

[ "PUB00009972", "PUB00071774" ]

[ "1779764", "20163190" ]

[ "Magnesium transport in Salmonella typhimurium: the influence of new mutations conferring Co2+ resistance on the CorA Mg2+ transport system.", "The putative Na+/H+ antiporter of Vibrio cholerae, Vc-NhaP2, mediates the specific K+/H+ exchange in vivo." ]

[ 1991, 2010 ]

2

[]

0

null

[ "Archaea", "Bacteria", "Caudoviricetes", "Eukaryota", "unclassified sequences" ]

[ 958, 65020, 2, 1021, 1008 ]

5

[ "Arabidopsis thaliana", "Escherichia coli (strain K12)", "Homo sapiens", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 8, 6, 1, 5, 4 ]

5

true

Domain

Transporter-associated domain

Transptr-assoc_dom

8

IPR005173

5,173

DMRTA motif

DMA

Domain

2,754

false

This entry represents the DMA domain found to the C terminus of the DM DNA-binding domain [ ] in Doublesex- and mab-3-related transcription factors (Dmrt proteins) from eukaryotes. These proteins are involved in sexual development [ ]. The function of the region DMA, conserved in Dmrt3, Dmrt4, and Dmrt5 (also known as ...

[]

0

[ "PFAM" ]

[ "PF03474" ]

[ "DMA" ]

[ 2754 ]

1

[]

0

[]

0

[ "PUB00008363", "PUB00099677", "PUB00099678", "PUB00099679" ]

[ "10729224", "15474464", "22425532", "23064029" ]

[ "The human doublesex-related gene, DMRT2, is homologous to a gene involved in somitogenesis and encodes a potential bicistronic transcript.", "Molecular cloning, characterization, and expression in brain and gonad of Dmrt5 of zebrafish.", "Dmrt genes in the development and evolution of sexual dimorphism.", "T...

[ 2000, 2004, 2012, 2013 ]

4

[]

0

null

[ "Opisthokonta" ]

[ 2754 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 4, 2, 5, 4, 5 ]

6

true

Domain

DMRTA motif

DMA

6

IPR005174

5,174

KIB1-4, beta-propeller

KIB1-4_b-propeller

Domain

33,474

false

This entry, previously known as DUF295, represents the β-propeller domain found in F-box proteins KIB1-4, from Arabidopsis thaliana, and similar plant proteins. This domain adopts a β-propeller structure with 6 blades and is often found in association with F-box domain ( ). KIB1-4 are ubiquitin ligases that act as esse...

[]

0

[ "PFAM" ]

[ "PF03478" ]

[ "Beta-prop_KIB1-4" ]

[ 33474 ]

1

[]

0

[]

0

[ "PUB00045184", "PUB00094297", "PUB00096735", "PUB00155429", "PUB00155946", "PUB00155992" ]

[ "10607296", "28575660", "30938771", "29263319", "8565821", "32061894" ]

[ "The UNUSUAL FLORAL ORGANS gene of Arabidopsis thaliana is an F-box protein required for normal patterning and growth in the floral meristem.", "The F-box Protein KIB1 Mediates Brassinosteroid-Induced Inactivation and Degradation of GSK3-like Kinases in Arabidopsis.", "Neofunctionalization of Mitochondrial Prot...

[ 1999, 2017, 2019, 2017, 1996, 2020 ]

6

[]

0

null

[ "Eukaryota", "Nocardiopsis terrae" ]

[ 33473, 1 ]

2

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 528, 624, 231 ]

3

true

Domain

KIB1-4, beta-propeller

KIB1-4_b-propeller

4

IPR005177

5,177

Bifunctional kinase-pyrophosphorylase

Kinase-pyrophosphorylase

Family

13,496

false

This family of regulatory proteins has ADP-dependent kinase and inorganic phosphate-dependent pyrophosphorylase activity [ , , ].

[ "GO:0005524", "GO:0016772" ]

[ "ATP binding", "transferase activity, transferring phosphorus-containing groups" ]

[ "molecular_function", "molecular_function" ]

2

[ "NCBIFAM", "PFAM", "PANTHER" ]

[ "NF003742", "PF03618", "PTHR31756" ]

[ "PRK05339.1", "Kinase-PPPase", "" ]

[ 12935, 13473, 13401 ]

3

[ "EC", "EC" ]

[ "2.7.11", "2.7.4" ]

[ "EC:2.7.11", "EC:2.7.4" ]

2

[ "5d0n", "5d1f" ]

2

[ "PUB00044657", "PUB00057469", "PUB00057470" ]

[ "16696949", "17996018", "20044937" ]

[ "Cloning and expression of maize-leaf pyruvate, Pi dikinase regulatory protein gene.", "The pyruvate, orthophosphate dikinase regulatory proteins of Arabidopsis possess a novel, unprecedented Ser/Thr protein kinase primary structure.", "Cloning and characterization of Escherichia coli DUF299: a bifunctional ADP...

[ 2006, 2008, 2010 ]

3

[]

[ "IPR026530", "IPR026565" ]

0

2

0

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 12442, 929, 125 ]

3

[ "Arabidopsis thaliana", "Escherichia coli (strain K12)", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 10, 1, 1, 11 ]

4

true

Family

Bifunctional kinase-pyrophosphorylase

Kinase-pyrophosphorylase

6

IPR005180

5,180

Domain of unknown function DUF302

DUF302

Domain

11,020

false

This domain is found in poorly characterised set of proteins, including the putative fluoride ion transporter CrcB 1 and CrcB 2 (also known as FluC 1 and FluC 2) from Brucella sp. It normally occurs uniquely within a sequence, but is found as a tandem repeat ( ). It has an interesting phylogenetic distribution with the...

[]

0

[ "PFAM", "CDD" ]

[ "PF03625", "cd14797" ]

[ "DUF302", "DUF302" ]

[ 11018, 9929 ]

2

[]

0

[ "1j3m", "1q9u", "7tj1" ]

3

[ "PUB00028717" ]

[ "15481054" ]

[ "Crystal structure of a conserved hypothetical protein TT1751 from Thermus thermophilus HB8." ]

[ 2004 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 767, 9533, 396, 324 ]

4

[]

0

true

Domain

Domain of unknown function DUF302

DUF302

4

IPR005181

5,181

Sialate O-acetylesterase domain

SASA

Domain

16,290

false

This entry represents a domain found in eukaryotic sialic acid acetylesterases (SIAEs). The catalytic triad of this esterase enzyme comprises residues Ser127, His403 and Asp391 in mouse SIAE [ , ]. Proteins containing this domain also include some uncharacterised bacterial proteins.

[]

0

[ "PFAM" ]

[ "PF03629" ]

[ "SASA" ]

[ 16290 ]

1

[]

0

[ "1zmb", "2apj", "3pt5", "7kmm", "8f9o", "8f9p", "8f9q", "8f9r", "9ega", "9h4u" ]

10

[ "PUB00039360", "PUB00078761" ]

[ "16301800", "20555325" ]

[ "The structure at 1.6 Angstroms resolution of the protein product of the At4g34215 gene from Arabidopsis thaliana.", "Functionally defective germline variants of sialic acid acetylesterase in autoimmunity." ]

[ 2005, 2010 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "Methanobacteriati", "Viruses", "unclassified sequences" ]

[ 12125, 3862, 11, 100, 192 ]

5

[ "Arabidopsis thaliana", "Danio rerio", "Escherichia coli (strain K12)", "Homo sapiens", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 8, 2, 1, 1, 16, 21 ]

6

true

Domain

Sialate O-acetylesterase domain

SASA

3

IPR005183

5,183

Domain of unknown function DUF305, CopM-like

DUF305_CopM-like

Domain

18,961

false

This entry represents a domain found in CopM from Synechocystis sp. (also known as Slr6039) and similar uncharacterised bacterial proteins. CopM is a cyanobacterial metallochaperone that shows a simple four-helical fold [ ]. This domain is also found in Uncharacterized protein L153 from Acanthamoeba polyphaga mimivirus...

[]

0

[ "PFAM" ]

[ "PF03713" ]

[ "DUF305" ]

[ 18961 ]

1

[]

0

[ "2qf9", "3bt5", "5fej", "5ffa", "5ffb", "5ffc", "5ffd", "5ffe", "7vw0", "7vw1", "7vw2" ]

11

[ "PUB00100984" ]

[ "27599732" ]

[ "Structural basis for copper/silver binding by the Synechocystis metallochaperone CopM." ]

[ 2016 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "metagenomes" ]

[ 22, 18558, 124, 26, 231 ]

5

[]

0

true

Domain

Domain of unknown function DUF305, CopM-like

DUF305_CopM-like

2

IPR005184

5,184

Domain of unknown function DUF306, Meta/HslJ

DUF306_Meta_HslJ

Domain

15,152

false

This entry represents a domain found in proteins of unknown function [ ], some of which are described as heat shock protein (HslJ). In Helicobacter pylori (Campylobacter pylori) the protein is secreted e.g. ( ) and implicated in motility. In Leishmania spp. it is described as an essential protein, over-expression of wh...

[]

0

[ "PFAM" ]

[ "PF03724" ]

[ "META" ]

[ 15152 ]

1

[]

0

[ "2kts", "2la7" ]

2

[ "PUB00016654", "PUB00016669", "PUB00088318" ]

[ "10403759", "12625841", "12892888" ]

[ "Leishmania: overexpression and comparative structural analysis of the stage-regulated meta 1 gene.", "New knowledge from old: in silico discovery of novel protein domains in Streptomyces coelicolor.", "Identification of the CysB-regulated gene, hslJ, related to the Escherichia coli novobiocin resistance phenot...

[ 1999, 2003, 2003 ]

3

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 122, 14726, 191, 113 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Domain

Domain of unknown function DUF306, Meta/HslJ

DUF306_Meta_HslJ

5

IPR005185

5,185

Inner membrane component domain

YccF

Domain

9,844

false

This domain occurs as one or more copies in bacterial and eukaryotic proteins. These are membrane proteins of four TM regions, two appearing in each of the two copies when both are present. Many of the latter members also carry the sodium/calcium exchanger membrane region ( ), which have multipass membrane regions [ , ...

[]

0

[ "PFAM" ]

[ "PF03733" ]

[ "YccF" ]

[ 9844 ]

1

[]

0

[]

0

[ "PUB00016669", "PUB00042652" ]

[ "12625841", "15919996" ]

[ "New knowledge from old: in silico discovery of novel protein domains in Streptomyces coelicolor.", "Global topology analysis of the Escherichia coli inner membrane proteome." ]

[ 2003, 2005 ]

2

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "metagenomes" ]

[ 24, 6900, 2869, 51 ]

4

[ "Danio rerio", "Escherichia coli (strain K12)", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 3, 1, 1, 1, 1 ]

5

true

Domain

Inner membrane component domain

YccF

1

IPR005186

5,186

FlaG protein

FlaG

Family

6,018

false

This entry includes protein FlaG (encoded from the flagellin locus) and an uncharacterised protein, YvyC, whose structure has been solved [ ]. In Aeromonas caviae, mutation of FlaG does not affect motility but does significantly reduce the level of its adherence to HEp-2 cells [ ].

[]

0

[ "PFAM", "PANTHER" ]

[ "PF03646", "PTHR37166" ]

[ "FlaG", "" ]

[ 6018, 5539 ]

2

[]

0

[ "2hc5", "6jsx" ]

2

[ "PUB00069751", "PUB00078328" ]

[ "19455708", "11401962" ]

[ "NMR structure of protein YvyC from Bacillus subtilis reveals unexpected structural similarity between two PFAM families.", "Motility and the polar flagellum are required for Aeromonas caviae adherence to HEp-2 cells." ]

[ 2009, 2001 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "environmental samples", "unclassified sequences" ]

[ 5907, 4, 2, 105 ]

4

[]

0

true

Family

FlaG protein

FlaG

6

IPR005189

5,189

Focal adhesion kinase, targeting (FAT) domain

Focal_adhesion_kin_target_dom

Domain

6,485

false

Focal adhesion kinase (FAK) is a tyrosine kinase found in focal adhesions, intracellular signalling complexes that are formed following engagement of the extracellular matrix by integrins. The C-terminal "focal adhesion targeting" (FAT) region is necessary and sufficient for localizing FAK to focal adhesions. The cryst...

[ "GO:0004713", "GO:0006468", "GO:0007172", "GO:0005925" ]

[ "protein tyrosine kinase activity", "protein phosphorylation", "signal complex assembly", "focal adhesion" ]

[ "molecular_function", "biological_process", "biological_process", "cellular_component" ]

4

[ "PFAM" ]

[ "PF03623" ]

[ "Focal_AT" ]

[ 6485 ]

1

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", ...

[ "2.7.10.2", "R-CEL-2029482", "R-CEL-354192", "R-CEL-354194", "R-CEL-375165", "R-CEL-3928662", "R-CEL-418885", "R-CEL-4420097", "R-CEL-5663213", "R-CEL-5673001", "R-CEL-8874081", "R-CEL-9009391", "R-CEL-9013420", "R-CEL-9860927", "R-GGA-111465", "R-GGA-2029482", "R-GGA-354192", "R-G...

[ "EC:2.7.10.2", "REACTOME:R-CEL-2029482", "REACTOME:R-CEL-354192", "REACTOME:R-CEL-354194", "REACTOME:R-CEL-375165", "REACTOME:R-CEL-3928662", "REACTOME:R-CEL-418885", "REACTOME:R-CEL-4420097", "REACTOME:R-CEL-5663213", "REACTOME:R-CEL-5673001", "REACTOME:R-CEL-8874081", "REACTOME:R-CEL-9009391...

81

[ "1k04", "1k05", "1k40", "1ktm", "1ow6", "1ow7", "1ow8", "1pv3", "1qvx", "2l6f", "2l6g", "2l6h", "2lk4", "3b71", "3gm1", "3gm2", "3gm3", "3s9o", "3u3f", "4r32", "4xef", "4xek", "4xev", "5f28", "6bz3", "6pw8", "7w7z", "7w8b", "7w8i", "7w9u" ]

30

[ "PUB00008366" ]

[ "11799401" ]

[ "The focal adhesion targeting (FAT) region of focal adhesion kinase is a four-helix bundle that binds paxillin." ]

[ 2002 ]

1

[]

0

null

[ "Bacteria", "Opisthokonta" ]

[ 2, 6483 ]

2

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 47, 8, 18, 9, 15 ]

6

true

Domain

Focal adhesion kinase, targeting (FAT) domain

Focal_adhesion_kin_target_dom

2

IPR005190

5,190

Glutamate-ammonia ligase adenylyltransferase, repeated domain

GlnE_rpt_dom

Domain

15,761

false

This is a conserved repeated domain found in GlnE proteins. These proteins adenylate and deadenylate glutamine synthases: ATP + {L-Glutamate:ammonia ligase (ADP-forming)} = Diphosphate + Adenylyl-{L-Glutamate:Ammonia ligase (ADP-forming)}. The domain is related to the nucleotidyltransferase domain .

[ "GO:0008882" ]

[ "[glutamate-ammonia-ligase] adenylyltransferase activity" ]

[ "molecular_function" ]

1

[ "PFAM" ]

[ "PF03710" ]

[ "GlnE" ]

[ 15761 ]

1

[ "EC", "EC" ]

[ "2.7.7.42", "2.7.7.89" ]

[ "EC:2.7.7.42", "EC:2.7.7.89" ]

2

[ "1v4a", "3k7d" ]

2

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 15511, 23, 227 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Domain

Glutamate-ammonia ligase adenylyltransferase, repeated domain

GlnE_rpt_dom

3

IPR005192

5,192

Glycoside hydrolase, family 49, C-terminal

Glyco_hydro_49_C

Domain

397

false

O-Glycosyl hydrolases ( ) are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycosyl hydrolases, based on sequence similarity, has led to the definition of 85 different families [ ,...

[]

0

[ "PFAM" ]

[ "PF03718" ]

[ "Glyco_hydro_49" ]

[ 397 ]

1

[ "CAZY", "EC" ]

[ "GH49", "3.2.1.11" ]

[ "CAZY:GH49", "EC:3.2.1.11" ]

2

[ "1ogm", "1ogo", "1wmr", "1x0c", "2z8g", "3wwg", "6nzs" ]

7

[ "PUB00004870", "PUB00005266" ]

[ "7624375", "8535779" ]

[ "Conserved catalytic machinery and the prediction of a common fold for several families of glycosyl hydrolases.", "Structures and mechanisms of glycosyl hydrolases." ]

[ 1995, 1995 ]

2

[]

0

null

[ "Bacteria", "Eukaryota" ]

[ 86, 311 ]

2

[]

0

true

Domain

Glycoside hydrolase, family 49, C-terminal

Glyco_hydro_49_C

7

IPR005193

5,193

Glycoside hydrolase, family 62, arabinosidase

GH62_arabinosidase

Family

3,431

false

This is a family of alpha -L-arabinofuranosidases ( ) which are all members of glycoside hydrolase family 62 ( ). This enzyme hydrolyzed aryl alpha-L-arabinofuranosides and cleaves arabinosyl side chains from arabinoxylan and arabinan. O-Glycosyl hydrolases ( ) are a widespread group of enzymes that hydrolyse the glyco...

[ "GO:0046556", "GO:0046373" ]

[ "alpha-L-arabinofuranosidase activity", "L-arabinose metabolic process" ]

[ "molecular_function", "biological_process" ]

2

[ "PFAM", "PANTHER", "CDD" ]

[ "PF03664", "PTHR40631", "cd08987" ]

[ "Glyco_hydro_62", "", "GH62" ]

[ 3421, 3414, 3035 ]

3

[ "CAZY", "EC" ]

[ "GH62", "3.2.1.55" ]

[ "CAZY:GH62", "EC:3.2.1.55" ]

2

[ "3wmy", "3wmz", "3wn0", "3wn1", "3wn2", "4n1i", "4n2r", "4n2z", "4n4b", "4o8n", "4o8o", "4o8p", "4pva", "4pvi", "5b6s", "5b6t", "5ubj", "6cc7", "6f1j" ]

19

[ "PUB00004870", "PUB00005266" ]

[ "7624375", "8535779" ]

[ "Conserved catalytic machinery and the prediction of a common fold for several families of glycosyl hydrolases.", "Structures and mechanisms of glycosyl hydrolases." ]

[ 1995, 1995 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 2134, 1293, 4 ]

3

[]

0

true

Family

Glycoside hydrolase, family 62, arabinosidase

GH62_arabinosidase

3

IPR005194

5,194

Glycoside hydrolase family 65, C-terminal

Glyco_hydro_65_C

Domain

13,842

false

Family 65 ( ) contains this domain and includes vacuolar acid trehalase and maltose phosphorylases. Maltose phosphorylase (MP) is a dimeric enzyme that catalyses the conversion of maltose and inorganic phosphate into beta-D-glucose-1-phosphate and glucose. The C-terminal domain forms a two layered jelly roll motif. Thi...

[]

0

[ "PFAM" ]

[ "PF03633" ]

[ "Glyco_hydro_65C" ]

[ 13842 ]

1

[ "CAZY" ]

[ "GH65" ]

[ "CAZY:GH65" ]

1

[ "1h54", "3qde", "3wiq", "3wir", "4ktp", "4ktr", "5mqr", "5mqs", "6w0p", "8ho7", "8ho8", "8ho9", "8hob", "8iyr", "9lb6", "9lb7" ]

16

[ "PUB00004870", "PUB00005266", "PUB00008368" ]

[ "7624375", "8535779", "11587643" ]

[ "Conserved catalytic machinery and the prediction of a common fold for several families of glycosyl hydrolases.", "Structures and mechanisms of glycosyl hydrolases.", "Crystal structure of maltose phosphorylase from Lactobacillus brevis: unexpected evolutionary relationship with glucoamylases." ]

[ 1995, 1995, 2001 ]

3

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 26, 12546, 1200, 70 ]

4

[ "Danio rerio", "Escherichia coli (strain K12)", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)" ]

[ 4, 1, 1, 1 ]

4

true

Domain

Glycoside hydrolase family 65, C-terminal

Glyco_hydro_65_C

7

IPR005195

5,195

Glycoside hydrolase, family 65, central catalytic

Glyco_hydro_65_M

Domain

15,340

false

The family of glycosyl hydrolases ( ) which contains this domain includes vacuolar acid trehalase and maltose phosphorylase. Maltose phosphorylase (MP) is a dimeric enzyme that catalyses the conversion of maltose and inorganic phosphate into beta-D-glucose-1-phosphate and glucose. The central domain is the catalytic do...

[ "GO:0003824", "GO:0005975" ]

[ "catalytic activity", "carbohydrate metabolic process" ]

[ "molecular_function", "biological_process" ]

2

[ "PFAM" ]

[ "PF03632" ]

[ "Glyco_hydro_65m" ]

[ 15340 ]

1

[ "CAZY", "EC" ]

[ "GH65", "3.2.1" ]

[ "CAZY:GH65", "EC:3.2.1" ]

2

[ "1h54", "3wiq", "3wir", "4ktp", "4ktr", "6w0p", "7fe3", "7fe4", "8iuc", "8yvr", "8yvs", "9lb6", "9lb7" ]

13

[ "PUB00004870", "PUB00005266", "PUB00008368" ]

[ "7624375", "8535779", "11587643" ]

[ "Conserved catalytic machinery and the prediction of a common fold for several families of glycosyl hydrolases.", "Structures and mechanisms of glycosyl hydrolases.", "Crystal structure of maltose phosphorylase from Lactobacillus brevis: unexpected evolutionary relationship with glucoamylases." ]

[ 1995, 1995, 2001 ]

3

[]

0

null

[ "Allomimiviridae", "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 2, 33, 12264, 2957, 84 ]

5

[ "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)" ]

[ 4, 1, 1, 4, 1, 3, 1 ]

7

true

Domain

Glycoside hydrolase, family 65, central catalytic

Glyco_hydro_65_M

1

IPR005196

5,196

Glycoside hydrolase, family 65, N-terminal

Glyco_hydro_65_N

Domain

13,187

false

This entry represents the N-terminal domain of the glycoside hydrolase family 65 proteins. The family of glycosyl hydrolases ( ) containing this domain includes vacuolar acid trehalase and maltose phosphorylase. Maltose phosphorylase (MP) is a dimeric enzyme that catalyses the conversion of maltose and inorganic phosph...

[ "GO:0003824", "GO:0005975" ]

[ "catalytic activity", "carbohydrate metabolic process" ]

[ "molecular_function", "biological_process" ]

2

[ "PFAM" ]

[ "PF03636" ]

[ "Glyco_hydro_65N" ]

[ 13187 ]

1

[ "CAZY" ]

[ "GH65" ]

[ "CAZY:GH65" ]

1

[ "1h54", "3wiq", "3wir", "4ktp", "4ktr", "6w0p", "7fe3", "7fe4", "8iuc", "8yvr", "8yvs", "9lb6", "9lb7" ]

13

[ "PUB00004870", "PUB00005266", "PUB00008368" ]

[ "7624375", "8535779", "11587643" ]

[ "Conserved catalytic machinery and the prediction of a common fold for several families of glycosyl hydrolases.", "Structures and mechanisms of glycosyl hydrolases.", "Crystal structure of maltose phosphorylase from Lactobacillus brevis: unexpected evolutionary relationship with glucoamylases." ]

[ 1995, 1995, 2001 ]

3

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 28, 11951, 1147, 61 ]

4

[ "Escherichia coli (strain K12)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)" ]

[ 1, 1 ]

2

true

Domain

Glycoside hydrolase, family 65, N-terminal

Glyco_hydro_65_N

2

IPR005197

5,197

Glycoside hydrolase family 71

Glyco_hydro_71

Family

5,520

false

This is a family of alpha-1,3-glucanases belonging to glycoside hydrolase family 71 ( ). Endo-1,3-alpha-glucanase Agn1 hydrolyses septum-edging material and acts in concert with endo-(1,3)-beta-glucanase Eng1 to achieve efficient cell separation in fission-yeast [ ]. O-Glycosyl hydrolases ( ) are a widespread group of ...

[ "GO:0051118" ]

[ "glucan endo-1,3-alpha-glucosidase activity" ]

[ "molecular_function" ]

1

[ "PFAM", "CDD" ]

[ "PF03659", "cd11577" ]

[ "Glyco_hydro_71", "GH71" ]

[ 5520, 5014 ]

2

[ "CAZY", "EC" ]

[ "GH71", "3.2.1.59" ]

[ "CAZY:GH71", "EC:3.2.1.59" ]

2

[ "8yfh", "9fnf", "9fng", "9fnh" ]

4

[ "PUB00004870", "PUB00005266", "PUB00074564" ]

[ "7624375", "8535779", "15194814" ]

[ "Conserved catalytic machinery and the prediction of a common fold for several families of glycosyl hydrolases.", "Structures and mechanisms of glycosyl hydrolases.", "Role of the alpha-glucanase Agn1p in fission-yeast cell separation." ]

[ 1995, 1995, 2004 ]

3

[]

0

null

[ "Bacteria", "Eukaryota", "Halapricum salinum", "metagenome" ]

[ 358, 5159, 1, 2 ]

4

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 6, 2 ]

2

true

Family

Glycoside hydrolase family 71

Glyco_hydro_71

1

IPR005198

5,198

Glycoside hydrolase, family 76

Glyco_hydro_76

Family

15,828

false

O-Glycosyl hydrolases ( ) are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycosyl hydrolases, based on sequence similarity, has led to the definition of 85 different families [ ,...

[]

0

[ "PFAM" ]

[ "PF03663" ]

[ "Glyco_hydro_76" ]

[ 15828 ]

1

[ "CAZY", "EC" ]

[ "GH76", "3.2.1.101" ]

[ "CAZY:GH76", "EC:3.2.1.101" ]

2

[ "3k7x", "4boj", "4bok", "4c1s", "4d4a", "4d4b", "4d4c", "4d4d", "4mu9", "4v1r", "4v1s", "5agd", "5m77", "5n0f", "6ry0", "6ry1", "6ry2", "6ry5", "6ry6", "6ry7", "6shd", "6shm", "6u4z", "6y8f", "6zbm", "6zbw", "6zbx", "7nl5", "9r4k", "9r4l", "9r4m", "9r4n"...

39

[ "PUB00004870", "PUB00005266" ]

[ "7624375", "8535779" ]

[ "Conserved catalytic machinery and the prediction of a common fold for several families of glycosyl hydrolases.", "Structures and mechanisms of glycosyl hydrolases." ]

[ 1995, 1995 ]

2

[]

[ "IPR014480", "IPR014512" ]

0

2

0

[ "Archaea", "Bacteria", "Eukaryota", "metagenomes" ]

[ 18, 4729, 11055, 26 ]

4

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 10, 2, 4 ]

3

true

Family

Glycoside hydrolase, family 76

Glyco_hydro_76

6

IPR005199

5,199

Glycoside hydrolase, family 79

Glyco_hydro_79

Family

6,406

false

O-Glycosyl hydrolases ( ) are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycosyl hydrolases, based on sequence similarity, has led to the definition of 85 different families [ ,...

[ "GO:0016798", "GO:0016020" ]

[ "hydrolase activity, acting on glycosyl bonds", "membrane" ]

[ "molecular_function", "cellular_component" ]

2

[ "PFAM" ]

[ "PF03662" ]

[ "Glyco_hydro_79n" ]

[ 6406 ]

1

[ "CAZY", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "GH79", "R-HSA-2024096", "R-HSA-6798695", "R-MMU-2024096", "R-MMU-6798695", "R-RNO-2024096", "R-RNO-6798695" ]

[ "CAZY:GH79", "REACTOME:R-HSA-2024096", "REACTOME:R-HSA-6798695", "REACTOME:R-MMU-2024096", "REACTOME:R-MMU-6798695", "REACTOME:R-RNO-2024096", "REACTOME:R-RNO-6798695" ]

7

[ "3vny", "3vnz", "3vo0", "5e8m", "5e97", "5e98", "5e9b", "5e9c", "5g0m", "5g0q", "5l77", "5l9y", "5l9z", "5la4", "5la7", "6zdm", "7eyo", "7pr7", "7pr8", "7prt", "7psh", "7psi", "7psj", "7psk", "7rg8", "7yi7", "7yjc", "8b0b", "8b0c", "8b0d", "8b0e", "8bac"...

43

[ "PUB00004870", "PUB00005266", "PUB00008371" ]

[ "7624375", "8535779", "11530216" ]

[ "Conserved catalytic machinery and the prediction of a common fold for several families of glycosyl hydrolases.", "Structures and mechanisms of glycosyl hydrolases.", "Molecular properties and involvement of heparanase in cancer progression and normal development." ]

[ 1995, 1995, 2001 ]

3

[]

0

null

[ "Bacteria", "Eukaryota", "ecological metagenomes" ]

[ 233, 6170, 3 ]

3

[ "Arabidopsis thaliana", "Danio rerio", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 17, 10, 9, 3, 16, 7, 50 ]

7

true

Family

Glycoside hydrolase, family 79

Glyco_hydro_79

5

IPR005200

5,200

Endo-1,3(4)-beta-glucanase

Endo-beta-glucanase

Family

6,438

false

This is a family of endo-beta-1,3(4)-glucanases belonging to glycoside hydrolase family 81 ( ) that are also known as Glucan endo-1,3-beta-D-glucosidases. Proteins in this entry include fission yeast Eng1/Eng2 and budding yeast Dse4 (also known as Eng1). They have been shown to hydrolyse linear beta-1,3-glucan chains [...

[ "GO:0042973" ]

[ "glucan endo-1,3-beta-D-glucosidase activity" ]

[ "molecular_function" ]

1

[ "PROFILE", "PANTHER" ]

[ "PS52008", "PTHR31983" ]

[ "GH81", "" ]

[ 6267, 6381 ]

2

[ "CAZY", "EC" ]

[ "GH81", "3.2.1.39" ]

[ "CAZY:GH81", "EC:3.2.1.39" ]

2

[ "4k35", "4k3a", "5t49", "5t4a", "5t4c", "5t4g", "5upi", "5upm", "5upn", "5upo", "5v1w", "5xbz", "5xc2", "6fop" ]

14

[ "PUB00004870", "PUB00005266", "PUB00077097", "PUB00077098", "PUB00077099", "PUB00077100", "PUB00153249", "PUB00153250", "PUB00153251" ]

[ "7624375", "8535779", "12665550", "12455695", "17933563", "25040903", "24100321", "28781080", "29870811" ]

[ "Conserved catalytic machinery and the prediction of a common fold for several families of glycosyl hydrolases.", "Structures and mechanisms of glycosyl hydrolases.", "The endo-beta-1,3-glucanase eng1p is required for dissolution of the primary septum during cell separation in Schizosaccharomyces pombe.", "En...

[ 1995, 1995, 2003, 2002, 2008, 2014, 2013, 2017, 2018 ]

9

[]

0

null

[ "Bacteria", "Eukaryota", "Pithovirus LCPAC101", "Stenosarchaea group", "metagenomes" ]

[ 1419, 4972, 1, 40, 6 ]

5

[ "Arabidopsis thaliana", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)", "Zea mays" ]

[ 11, 1, 3, 2, 2, 8 ]

6

true

Family

Endo-1,3(4)-beta-glucanase

Endo-beta-glucanase

5

IPR005201

5,201

Cytosolic endo-beta-N-acetylglucosaminidase, TIM barrel domain

TIM_ENGase

Domain

5,258

false

This describes the TIM barrel fold in ENGase, which contains a β/α fold [ ]. Endo-β-N-acetylglucosaminidase (ENGase) is a glycosyl hydrolase that cleaves the β-1,4-glycosidic bond within the di-N-acetylchitobiose core of N-glycosylated proteins, leaving one N-acetylglucosamine residue attached to the protein and releas...

[ "GO:0033925", "GO:0005737" ]

[ "mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity", "cytoplasm" ]

[ "molecular_function", "cellular_component" ]

2

[ "PFAM" ]

[ "PF03644" ]

[ "Glyco_hydro_85" ]

[ 5258 ]

1

[ "CAZY", "EC", "REACTOME", "REACTOME", "REACTOME" ]

[ "GH85", "3.2.1.96", "R-DRE-532668", "R-HSA-532668", "R-MMU-532668" ]

[ "CAZY:GH85", "EC:3.2.1.96", "REACTOME:R-DRE-532668", "REACTOME:R-HSA-532668", "REACTOME:R-MMU-532668" ]

5

[ "2vtf", "2w91", "2w92", "3fha", "3fhq", "3gdb" ]

6

[ "PUB00004870", "PUB00005266", "PUB00051965", "PUB00160853" ]

[ "7624375", "8535779", "19252736", "1233211" ]

[ "Conserved catalytic machinery and the prediction of a common fold for several families of glycosyl hydrolases.", "Structures and mechanisms of glycosyl hydrolases.", "Structural basis and catalytic mechanism for the dual functional endo-beta-N-acetylglucosaminidase A.", "The measurement of drug consumption. ...

[ 1995, 1995, 2009, 1975 ]

4

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 1623, 3633, 2 ]

3

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 18, 3, 1, 5, 4, 2, 5, 2, 7 ]

9

true

Domain

Cytosolic endo-beta-N-acetylglucosaminidase, TIM barrel domain

TIM_ENGase

4

IPR005202

5,202

Transcription factor GRAS

TF_GRAS

Family

30,646

false

Sequence analysis of the products of the GRAS (GAI, RGA, SCR) gene family indicates that they share a variable N terminus and a highly conserved C terminus that contains five recognizable motifs [ ]. Proteins in the GRAS family are major players in gibberellin (GA) signaling, which regulates various aspects of plant gr...

[]

0

[ "PFAM", "PROFILE", "PANTHER" ]

[ "PF03514", "PS50985", "PTHR31636" ]

[ "GRAS", "GRAS", "" ]

[ 30517, 30447, 29299 ]

3

[ "PROSITEDOC" ]

[ "PDOC50985" ]

[ "PROSITEDOC:PDOC50985" ]

1

[ "5b3g", "5b3h", "5hyz", "6kpb", "6kpd", "9lum", "9lun", "9luo", "9lup", "9o4j", "9o4k", "9oi8" ]

12

[ "PUB00008372", "PUB00008373", "PUB00066769" ]

[ "10341448", "10817761", "22829623" ]

[ "The GRAS gene family in Arabidopsis: sequence characterization and basic expression analysis of the SCARECROW-LIKE genes.", "PAT1, a new member of the GRAS family, is involved in phytochrome A signal transduction.", "Bacterial GRAS domain proteins throw new light on gibberellic acid response mechanisms." ]

[ 1999, 2000, 2012 ]

3

[]

0

null

[ "Bacteria", "Eukaryota", "marine sediment metagenome" ]

[ 137, 30508, 1 ]

3

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 153, 166, 261 ]

3

true

Family

Transcription factor GRAS

TF_GRAS

1

IPR005203

5,203

Hemocyanin, C-terminal

Hemocyanin_C

Domain

3,959

false

This entry represents the C-terminal domain of hemocyanin and hexamerin proteins. Crustacean and cheliceratan hemocyanins (oxygen-transport proteins) and insect hexamerins (storage proteins) are homologous gene products, although the latter do not bind oxygen [ ]. Haemocyanins are found in the haemolymph of many invert...

[]

0

[ "PFAM" ]

[ "PF03723" ]

[ "Hemocyanin_C" ]

[ 3959 ]

1

[]

0

[ "1hc1", "1hcy", "1ll1", "1lla", "1nol", "1oxy", "3gwj", "3hhs", "3ixv", "3ixw", "3wjm", "3wky", "4l37", "4yzw", "5yy2", "5yy3", "6l8s", "7ze1", "8ca9", "8cad", "8can", "8ji8", "8jib", "8po9" ]

24

[ "PUB00000297", "PUB00059233", "PUB00082624", "PUB00100820" ]

[ "3207675", "8015442", "25251934", "25859931" ]

[ "cDNA cloning of the Octopus dofleini hemocyanin: sequence of the carboxyl-terminal domain.", "Evolution of arthropod hemocyanins and insect storage proteins (hexamerins).", "Non-heme dioxygenase catalyzes atypical oxidations of 6,7-bicyclic systems to form the 6,6-quinolone core of viridicatin-type fungal alka...

[ 1988, 1994, 2014, 2015 ]

4

[]

0

null

[ "Bacteria", "Eukaryota" ]

[ 43, 3916 ]

2

[ "Drosophila melanogaster" ]

[ 17 ]

1

true

Domain

Hemocyanin, C-terminal

Hemocyanin_C

5

IPR005204

5,204

Hemocyanin, N-terminal

Hemocyanin_N

Domain

3,334

false

This entry represents the N-terminal domain of hemocyanin and hexamerin proteins. Crustacean and cheliceratan hemocyanins (oxygen-transport proteins) and insect hexamerins (storage proteins) are homologous gene products, although the latter do not bind oxygen [ ]. Haemocyanins are found in the haemolymph of many invert...

[]

0

[ "PFAM" ]

[ "PF03722" ]

[ "Hemocyanin_N" ]

[ 3334 ]

1

[]

0

[ "1hc1", "1hcy", "1ll1", "1lla", "1nol", "1oxy", "3gwj", "3hhs", "3ixv", "3ixw", "3wjm", "3wky", "4l37", "4yzw", "6l8s", "7ze1", "8ca9", "8cad", "8can", "8ji8", "8jib", "8po9" ]

22

[ "PUB00000297", "PUB00059233", "PUB00082624", "PUB00100820" ]

[ "3207675", "8015442", "25251934", "25859931" ]

[ "cDNA cloning of the Octopus dofleini hemocyanin: sequence of the carboxyl-terminal domain.", "Evolution of arthropod hemocyanins and insect storage proteins (hexamerins).", "Non-heme dioxygenase catalyzes atypical oxidations of 6,7-bicyclic systems to form the 6,6-quinolone core of viridicatin-type fungal alka...

[ 1988, 1994, 2014, 2015 ]

4

[]

0

null

[ "Bacteria", "Bilateria" ]

[ 6, 3328 ]

2

[ "Drosophila melanogaster" ]

[ 20 ]

1

true

Domain

Hemocyanin, N-terminal

Hemocyanin_N

3

IPR005205

5,205

Herpesvirus ICP4-like protein, C-terminal

Herpes_ICP4_C

Domain

646

false

The immediate-early protein ICP4 (infected-cell polypeptide 4) is required for efficient transcription of early and late viral genes and is thus essential for productive infection. ICP4 is a large phosphoprotein that binds DNA in a sequence specific manner as a homodimer. ICP4 represses transcription from LAT, ICP4 and...

[ "GO:0045893" ]

[ "positive regulation of DNA-templated transcription" ]

[ "biological_process" ]

1

[ "PFAM" ]

[ "PF03585" ]

[ "Herpes_ICP4_C" ]

[ 646 ]

1

[]

0

[]

0

[ "PUB00008374" ]

[ "11739685" ]

[ "Identification of a motif in the C terminus of herpes simplex virus regulatory protein ICP4 that contributes to activation of transcription." ]

[ 2002 ]

1

[]

0

null

[ "Alphaherpesvirinae" ]

[ 646 ]

1

[]

0

true

Domain

Herpesvirus ICP4-like protein, C-terminal

Herpes_ICP4_C

3

IPR005206

5,206

Herpesvirus ICP4-like protein, N-terminal

Herpes_ICP4_N

Domain

520

false

The immediate-early protein ICP4 (infected-cell polypeptide 4) is required for efficient transcription of early and late viral genes and is thus essential for productive infection. ICP4 is a large phosphoprotein that binds DNA in a sequence specific manner as a homodimer. ICP4 represses transcription from LAT, ICP4 and...

[ "GO:0045893" ]

[ "positive regulation of DNA-templated transcription" ]

[ "biological_process" ]

1

[ "PFAM" ]

[ "PF03584" ]

[ "Herpes_ICP4_N" ]

[ 520 ]

1

[]

0

[ "5mhj", "5mhk" ]

2

[ "PUB00008374" ]

[ "11739685" ]

[ "Identification of a motif in the C terminus of herpes simplex virus regulatory protein ICP4 that contributes to activation of transcription." ]

[ 2002 ]

1

[]

0

null

[ "Alphaherpesvirinae" ]

[ 520 ]

1

[]

0

true

Domain

Herpesvirus ICP4-like protein, N-terminal

Herpes_ICP4_N

1

IPR005207

5,207

Herpesvirus UL14-like

Herpes_UL14

Family

175

false

This is a family of Herpesvirus proteins including UL14. UL14 protein is a minor component of the virion tegument [ ] and is expressed late in infection. UL14 protein can influence the intracellular localization patterns of a number of proteins belonging to the capsid or the DNA encapsidation machinery [ ].

[]

0

[ "PFAM" ]

[ "PF03580" ]

[ "Herpes_UL14" ]

[ 175 ]

1

[]

0

[]

0

[ "PUB00008377", "PUB00008378" ]

[ "10590088", "11161269" ]

[ "Herpes simplex virus type 1 gene UL14: phenotype of a null mutant and identification of the encoded protein.", "The UL14 protein of herpes simplex virus type 2 translocates the minor capsid protein VP26 and the DNA cleavage and packaging UL33 protein into the nucleus of coexpressing cells." ]

[ 2000, 2001 ]

2

[]

0

null

[ "Alphaherpesvirinae" ]

[ 175 ]

1

[]

0

true

Family

Herpesvirus UL14-like

Herpes_UL14

6

IPR005208

5,208

Herpesvirus tripartite terminase subunit 2

Herpes_TT2

Family

282

false

This is a family of Herpesvirus proteins including UL33 ( ) [ ] and UL51 ( ) [ ]. These proteins constitute the T-terminase subunit of the tripartite terminase complex that assembles in the cytoplasm of infected cells and uses the host nuclear import machinery to enter the nucleus, where capsid assembly and genome-pack...

[ "GO:0019073" ]

[ "viral DNA genome packaging" ]

[ "biological_process" ]

1

[ "HAMAP", "PFAM" ]

[ "MF_04015", "PF03581" ]

[ "HSV_TRM2", "Herpes_UL33" ]

[ 270, 282 ]

2

[ "REACTOME" ]

[ "R-HSA-9610379" ]

[ "REACTOME:R-HSA-9610379" ]

1

[ "6m5r", "6m5s", "6m5u", "6m5v" ]

4

[ "PUB00019690", "PUB00079196", "PUB00079197" ]

[ "1845831", "27033706", "23175377" ]

[ "The herpes simplex virus UL33 gene product is required for the assembly of full capsids.", "Divergent Evolution of Nuclear Localization Signal Sequences in Herpesvirus Terminase Subunits.", "The human cytomegalovirus UL51 protein is essential for viral genome cleavage-packaging and interacts with the terminase...

[ 1991, 2016, 2013 ]

3

[]

0

null

[ "Herpesvirales", "Homo sapiens" ]

[ 281, 1 ]

2

[ "Homo sapiens" ]

[ 1 ]

1

true

Family

Herpesvirus tripartite terminase subunit 2

Herpes_TT2

2

IPR005210

5,210

Herpesvirus large tegument protein deneddylase

Herpes_LT_deneddylase

Domain

1,007

false

BPLF1, the Epstein-Barr-virus-encoded member of this protease family, is a deneddylase that regulates virus production by modulating the activity of cullin-RING ligases. Homologues encoded by other herpesviruses share the deneddylase activity [ ].

[ "GO:0019784", "GO:0039693" ]

[ "deNEDDylase activity", "viral DNA genome replication" ]

[ "molecular_function", "biological_process" ]

2

[ "PFAM" ]

[ "PF03586" ]

[ "Herpes_UL36" ]

[ 1007 ]

1

[ "EC", "EC" ]

[ "3.4.19.12", "3.4.22.-" ]

[ "EC:3.4.19.12", "EC:3.4.22.-" ]

2

[ "5zz8", "6cgr", "6m6g", "6m6h", "6odm", "9no1" ]

6

[ "PUB00074566" ]

[ "20190741" ]

[ "A deneddylase encoded by Epstein-Barr virus promotes viral DNA replication by regulating the activity of cullin-RING ligases." ]

[ 2010 ]

1

[]

0

null

[ "Alphaherpesvirinae" ]

[ 1007 ]

1

[]

0

true

Domain

Herpesvirus large tegument protein deneddylase

Herpes_LT_deneddylase

6

IPR005211

5,211

Herpesvirus envelope glycoprotein N domain

Herpes_glycoprotein_N_domain

Domain

466

false

This entry represents a conserved region found in a number of viral proteins: BLRF1, U46, 53, and UL73, collectively known as glycoprotein N. These UL73-like envelope glycoproteins, which associate in a high molecular mass complex with their counterpart protein gM, induce neutralizing antibody responses in the host. Th...

[]

0

[ "PFAM" ]

[ "PF03554" ]

[ "Herpes_UL73" ]

[ 466 ]

1

[ "REACTOME", "REACTOME" ]

[ "R-HSA-9609690", "R-HSA-9610379" ]

[ "REACTOME:R-HSA-9609690", "REACTOME:R-HSA-9610379" ]

2

[]

0

[ "PUB00008383" ]

[ "11602789" ]

[ "gpUL73 (gN) genomic variants of human cytomegalovirus isolates are clustered into four distinct genotypes." ]

[ 2001 ]

1

[]

0

null

[ "Arthrobacter wenxiniae", "Homo sapiens", "Orthoherpesviridae" ]

[ 1, 4, 461 ]

3

[ "Homo sapiens" ]

[ 4 ]

1

true

Domain

Herpesvirus envelope glycoprotein N domain

Herpes_glycoprotein_N_domain

2

IPR005212

5,212

dTDP-4-dehydro-6-deoxy-alpha-D-glucopyranose 2,3-dehydratase

EvaA-like

Domain

1,457

false

This domain occurs in a range of proteins from antibiotic production pathways. These include the gra-ORF27 product that probably functions at an early step, most likely as a dTDP-4-keto-6- deoxyglucose-2,3-dehydratase [ ]. Its homologues include dnmT from the daunorubicin biosynthetic gene cluster in S. peucetius [ ], ...

[ "GO:0016829" ]

[ "lyase activity" ]

[ "molecular_function" ]

1

[ "PFAM" ]

[ "PF03559" ]

[ "Hexose_dehydrat" ]

[ 1457 ]

1

[ "EC" ]

[ "4.2.1.159" ]

[ "EC:4.2.1.159" ]

1

[ "4j7g", "4j7h" ]

2

[ "PUB00008384", "PUB00008385", "PUB00008386", "PUB00067254" ]

[ "9831526", "8955419", "8655529", "23473392" ]

[ "The granaticin biosynthetic gene cluster of Streptomyces violaceoruber Tu22: sequence analysis and expression in a heterologous host.", "Enhanced antibiotic production by manipulation of the Streptomyces peucetius dnrH and dnmT genes involved in doxorubicin (adriamycin) biosynthesis.", "Cloning, sequencing, an...

[ 1998, 1996, 1996, 2013 ]

4

[]

0

null

[ "Bacteria", "Nitrososphaerota", "unclassified sequences" ]

[ 1434, 6, 17 ]

3

[]

0

true

Domain

dTDP-4-dehydro-6-deoxy-alpha-D-glucopyranose 2,3-dehydratase

EvaA-like

6

IPR005213

5,213

HGWP repeat

HGWP_repeat

Repeat

343

false

This short (30 amino acids) repeat is found in a number of plant proteins. It contains a conserved HGWP motif, hence its name. The function of these proteins is unknown.

[]

0

[ "PFAM" ]

[ "PF03578" ]

[ "HGWP" ]

[ 343 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Oryza" ]

[ 343 ]

1

[ "Oryza sativa subsp. japonica" ]

[ 323 ]

1

true

Repeat

HGWP repeat

HGWP_repeat

9

IPR005214

5,214

IBV 3A protein

IBV_3A

Family

234

false

The gene product of gene 3 from Infectious bronchitis virus (strain CL190). Currently, the function of this protein remains unknown.

[]

0

[ "PFAM" ]

[ "PF03617" ]

[ "IBV_3A" ]

[ 234 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Gammacoronavirus" ]

[ 234 ]

1

[]

0

true

Family

IBV 3A protein

IBV_3A

1

IPR005215

5,215

Trigger factor

Trig_fac

Family

28,118

false

The trigger factor is found in several prokaryotes, and is involved in protein export. Trigger factor is a ribosome-associated molecular chaperone and is the first chaperone to interact with nascent polypeptide. It acts as a chaperone by maintaining the newly synthesised protein in an open conformation. It consists of ...

[ "GO:0015031" ]

[ "protein transport" ]

[ "biological_process" ]

1

[ "HAMAP", "PIRSF", "PANTHER", "NCBIFAM" ]

[ "MF_00303", "PIRSF003095", "PTHR30560", "TIGR00115" ]

[ "Trigger_factor_Tig", "Trigger_factor", "", "tig" ]

[ 22814, 23351, 25610, 25548 ]

4

[ "EC" ]

[ "5.2.1.8" ]

[ "EC:5.2.1.8" ]

1

[ "1oms", "1p9y", "1t11", "1w26", "1w2b", "2aar", "2d3o", "2mlx", "2mly", "2mlz", "2vrh", "3gty", "3gu0", "4urd", "5owi", "5owj", "6d6s", "6j0a", "6j45", "7d6z", "7d80", "7zgi", "8p7x", "8p7y", "8p8b", "8p8v", "8p8w", "8zfi", "9wnr" ]

29

[ "PUB00015317", "PUB00038013", "PUB00099906" ]

[ "15175291", "15334087", "29222465" ]

[ "Functional dissection of Escherichia coli trigger factor: unraveling the function of individual domains.", "Trigger factor in complex with the ribosome forms a molecular cradle for nascent proteins.", "The dynamic dimer structure of the chaperone Trigger Factor." ]

[ 2004, 2004, 2017 ]

3

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences", "uncultured Caudovirales phage" ]

[ 25626, 1959, 532, 1 ]

4

[ "Arabidopsis thaliana", "Escherichia coli (strain K12)", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 8, 1, 9, 21 ]

4

true

Family

Trigger factor

Trig_fac

6

IPR005216

5,216

Citrate lyase ligase

Citrate_lyase_ligase

Family

3,309

false

[Citrate (pro-3S)-lyase] ligase ( ), also known as citrate lyase ligase, is responsible for acetylation of the prosthetic group (2-(5''-phosphoribosyl)-3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase. It converts the inactive thiol form of the enzyme to the active form. In Clostridium sphenoides, citrate ...

[ "GO:0008771" ]

[ "[citrate (pro-3S)-lyase] ligase activity" ]

[ "molecular_function" ]

1

[ "PIRSF", "PANTHER", "NCBIFAM", "CDD" ]

[ "PIRSF005751", "PTHR40599", "TIGR00124", "cd02169" ]

[ "Acet_citr_lig", "", "cit_ly_ligase", "Citrate_lyase_ligase" ]

[ 2975, 3309, 3017, 2012 ]

4

[ "EC", "GP" ]

[ "6.2.1.22", "GenProp0672" ]

[ "EC:6.2.1.22", "GP:GenProp0672" ]

2

[]

0

[ "PUB00044603" ]

[ "3935436" ]

[ "Covalent modification of citrate lyase ligase from Clostridium sphenoides by phosphorylation/dephosphorylation." ]

[ 1985 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 3290, 3, 16 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Citrate lyase ligase

Citrate_lyase_ligase

6

IPR005217

5,217

Iron permease EfeU/FTR1-like

EfeU/FTR1-like

Family

561

false

Fungi uptake extracellular ferrous iron (Fe2+) using a bipartite high-affinity transporter consisting of a multicopper ferroxidase associated with a membrane permease which translocates generated ferric iron (Fe3+) into the cytosol. The Saccharomyces cerevisiae (Baker's yeast) iron permease FTR1 is a plasma membrane pe...

[ "GO:0005381", "GO:0034755", "GO:0005886", "GO:0033573" ]

[ "iron ion transmembrane transporter activity", "iron ion transmembrane transport", "plasma membrane", "high-affinity iron permease complex" ]

[ "molecular_function", "biological_process", "cellular_component", "cellular_component" ]

4

[ "NCBIFAM" ]

[ "TIGR00145" ]

[ "" ]

[ 561 ]

1

[ "REACTOME" ]

[ "R-HSA-9638482" ]

[ "REACTOME:R-HSA-9638482" ]

1

[]

0

[ "PUB00015322", "PUB00067523", "PUB00070776" ]

[ "8599111", "17627767", "16987175" ]

[ "A permease-oxidase complex involved in high-affinity iron uptake in yeast.", "EfeUOB (YcdNOB) is a tripartite, acid-induced and CpxAR-regulated, low-pH Fe2+ transporter that is cryptic in Escherichia coli K-12 but functional in E. coli O157:H7.", "A new ferrous iron-uptake transporter, EfeU (YcdN), from Escher...

[ 1996, 2007, 2006 ]

3

[ "IPR004923" ]

[]

1

0

1

[ "Archaeoglobus fulgidus", "Bacteria", "saccharomyceta" ]

[ 3, 502, 56 ]

3

[ "Escherichia coli (strain K12)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)" ]

[ 1, 1 ]

2

true

Family

Iron permease EfeU/FTR1-like

EfeU/FTR1-like

4

IPR005218

5,218

Diacylglycerol/lipid kinase

Diacylglycerol/lipid_kinase

Family

19,082

false

This protein family include proteins predominantly from bacteria but also from some archaeal and eukaryotic species. The Escherichia coli member of this family, YegS, has been purified and shown to have phosphatidylglycerol kinase activity [ ]. DagK from Bacillus subtilis catalyses the phosphorylation of diacylglycerol...

[ "GO:0005524", "GO:0016301", "GO:0008654", "GO:0016310" ]

[ "ATP binding", "kinase activity", "phospholipid biosynthetic process", "phosphorylation" ]

[ "molecular_function", "molecular_function", "biological_process", "biological_process" ]

4

[ "NCBIFAM" ]

[ "TIGR00147" ]

[ "" ]

[ 19082 ]

1

[ "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC" ]

[ "2.7.1.-", "PWY-5129", "PWY-6322", "PWY-6369", "PWY-6626", "PWY-6682", "PWY-6955", "PWY-7077", "PWY-7321", "PWY-7740", "PWY-7769", "PWY-7886", "PWY-7948", "PWY-7975", "PWY-8129", "PWY-8324", "PWY-8367", "PWY-8392", "PWY-8393", "PWY-8394", "PWY-8402" ]

[ "EC:2.7.1.-", "METACYC:PWY-5129", "METACYC:PWY-6322", "METACYC:PWY-6369", "METACYC:PWY-6626", "METACYC:PWY-6682", "METACYC:PWY-6955", "METACYC:PWY-7077", "METACYC:PWY-7321", "METACYC:PWY-7740", "METACYC:PWY-7769", "METACYC:PWY-7886", "METACYC:PWY-7948", "METACYC:PWY-7975", "METACYC:PWY-8...

21

[ "2bon", "2jgr", "2p1r", "2qv7", "2qvl", "3s40", "3t5p", "4wer", "4wrr" ]

9

[ "PUB00039707", "PUB00053893", "PUB00099966" ]

[ "17351295", "17535816", "22236066" ]

[ "Crystal structure of YegS, a homologue to the mammalian diacylglycerol kinases, reveals a novel regulatory metal binding site.", "Identification of a soluble diacylglycerol kinase required for lipoteichoic acid production in Bacillus subtilis.", "Phytosphingosine-phosphate is a signal for AtMPK6 activation and...

[ 2007, 2007, 2012 ]

3

[]

[ "IPR022433" ]

0

1

0

[ "Archaea", "Bacteria", "Catovirus CTV1", "Eukaryota", "unclassified sequences" ]

[ 164, 18192, 1, 475, 250 ]

5

[ "Arabidopsis thaliana", "Escherichia coli (strain K12)", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 2, 1, 2, 2 ]

4

true

Family

Diacylglycerol/lipid kinase

Diacylglycerol/lipid_kinase

3

IPR005219

5,219

Intermembrane transport protein PqiA-like, proteobacteria

PqiA-like_proteobact

Family

4,547

false

This family consists of proteins from proteobacteria, including intermembrane transport proteins PqiA and YebS, which are components of transport pathways that contribute to membrane integrity [ ]. The promoter for the pqiA gene is inducible by paraquat, a superoxide radical-generating agent, and other known superoxide...

[]

0

[ "NCBIFAM" ]

[ "TIGR00155" ]

[ "pqiA_fam" ]

[ 4547 ]

1

[]

0

[ "9n8w", "9n8x" ]

2

[ "PUB00009983", "PUB00089644" ]

[ "7751275", "27795327" ]

[ "Isolation of a novel paraquat-inducible (pqi) gene regulated by the soxRS locus in Escherichia coli.", "pqiABC and yebST, Putative mce Operons of Escherichia coli, Encode Transport Pathways and Contribute to Membrane Integrity." ]

[ 1995, 2017 ]

2

[ "IPR007498" ]

[]

1

0

1

[ "Bacteria", "Opisthokonta", "metagenomes" ]

[ 4540, 3, 4 ]

3

[ "Escherichia coli (strain K12)" ]

[ 2 ]

1

true

Family

Intermembrane transport protein PqiA-like, proteobacteria

PqiA-like_proteobact

5

IPR005222

5,222

Competence protein ComF

Competence_ComF

Family

676

false

Competence is the ability of a cell to take up exogenous DNA from its environment, resulting in transformation. It is widespread among bacteria and is probably an important mechanism for the horizontal transfer of genes. DNA usually becomes available by the death and lysis of other cells. Competent bacteria use compone...

[]

0

[ "NCBIFAM" ]

[ "TIGR00201" ]

[ "comF" ]

[ 676 ]

1

[ "GP" ]

[ "GenProp0311" ]

[ "GP:GenProp0311" ]

1

[]

0

[ "PUB00033880", "PUB00033881", "PUB00033882", "PUB00052316", "PUB00052317" ]

[ "1577704", "8412657", "9871335", "8901420", "10361283" ]

[ "Donor DNA processing is blocked by a mutation in the com101A locus of Haemophilus influenzae.", "comF, a Bacillus subtilis late competence locus, encodes a protein similar to ATP-dependent RNA/DNA helicases.", "The gluconate high affinity transport of GntI in Escherichia coli involves a multicomponent complex ...

[ 1992, 1993, 1998, 1996, 1999 ]

5

[]

0

null

[ "Bacteria" ]

[ 676 ]

1

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Competence protein ComF

Competence_ComF

9

IPR005224

5,224

Sugar fermentation stimulation protein

SfsA

Family

8,567

false

This family contains sugar fermentation stimulation protein SfsA, which is probably a regulatory factor involved in maltose metabolism. SfsA has been shown to bind DNA [ ] and described as a nuclease, as it contains a well-conserved PDDEXK nuclease active site. The structure of SfsA has been solved ( , )

[ "GO:0003677" ]

[ "DNA binding" ]

[ "molecular_function" ]

1

[ "HAMAP", "PANTHER", "NCBIFAM", "CDD" ]

[ "MF_00095", "PTHR30545", "TIGR00230", "cd22359" ]

[ "SfsA", "", "sfsA", "SfsA-like_bacterial" ]

[ 7812, 8429, 8027, 7883 ]

4

[]

0

[ "4da2", "4dap", "4dav" ]

3

[ "PUB00020332" ]

[ "11272834" ]

[ "Effects of the Escherichia coli sfsA gene on mal genes expression and a DNA binding activity of SfsA." ]

[ 2001 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 308, 7849, 235, 4, 171 ]

5

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Sugar fermentation stimulation protein

SfsA

9

IPR005225

5,225

Small GTP-binding domain

Small_GTP-bd

Domain

662,044

false

Proteins with a small GTP-binding domain include Ras, RhoA, Rab11, translation elongation factor G, translation initiation factor IF-2, tetratcycline resistance protein TetM, CDC42, Era, ADP-ribosylation factors [ ], tdhF, and many others [ ]. In some proteins the domain occurs more than once. Among them there is a lar...

[ "GO:0005525" ]

[ "GTP binding" ]

[ "molecular_function" ]

1

[ "NCBIFAM" ]

[ "TIGR00231" ]

[ "small_GTP" ]

[ 662044 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-114604", "R-BTA-114608", "R-BTA-1222556", "R-BTA-1257604", "R-BTA-156902", "R-BTA-1655829", "R-BTA-1660499", "R-BTA-1660514", "R-BTA-170968", "R-BTA-170984", "R-BTA-181429", "R-BTA-181430", "R-BTA-182971", "R-BTA-193634", "R-BTA-198203", "R-BTA-199992", "R-BTA-2029482", "R-B...

[ "REACTOME:R-BTA-114604", "REACTOME:R-BTA-114608", "REACTOME:R-BTA-1222556", "REACTOME:R-BTA-1257604", "REACTOME:R-BTA-156902", "REACTOME:R-BTA-1655829", "REACTOME:R-BTA-1660499", "REACTOME:R-BTA-1660514", "REACTOME:R-BTA-170968", "REACTOME:R-BTA-170984", "REACTOME:R-BTA-181429", "REACTOME:R-BT...

1,404

[ "121p", "1a2b", "1a4r", "1aa9", "1agp", "1aip", "1aje", "1am4", "1an0", "1b23", "1bkd", "1byu", "1c1y", "1cc0", "1cee", "1cf4", "1clu", "1crp", "1crq", "1crr", "1ctq", "1cxz", "1d5c", "1d8t", "1dar", "1dg1", "1doa", "1dpf", "1ds6", "1e0a", "1e0s", "1e96"...

2,697

[ "PUB00015117", "PUB00095176" ]

[ "11995995", "17506703" ]

[ "Structure of small G proteins and their regulators.", "The small G proteins of the Arf family and their regulators." ]

[ 2001, 2007 ]

2

[]

[ "IPR031168" ]

0

1

0

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 6618, 265732, 384199, 196, 5299 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus",...

[ 438, 120, 417, 191, 11, 525, 487, 47, 244, 578, 43, 34, 536 ]

13

true

Domain

Small GTP-binding domain

Small_GTP-bd

1

IPR005226

5,226

UPF0014 family

UPF0014_fam

Family

9,978

false

Characterised proteins in this family include probable iron export permease protein FetB, which is part of the ABC transporter complex FetAB, probably involved in iron export [ ], and aluminum sensitive 3 protein, also part of an ABC transporter required for aluminum (Al) resistance [ ]. This family also includes integ...

[]

0

[ "PFAM", "PANTHER" ]

[ "PF03649", "PTHR30028" ]

[ "UPF0014", "" ]

[ 9975, 9849 ]

2

[]

0

[]

0

[ "PUB00070818", "PUB00070819" ]

[ "24038693", "15659095" ]

[ "Overexpression of fetA (ybbL) and fetB (ybbM), Encoding an Iron Exporter, Enhances Resistance to Oxidative Stress in Escherichia coli.", "ALS3 encodes a phloem-localized ABC transporter-like protein that is required for aluminum tolerance in Arabidopsis." ]

[ 2013, 2005 ]

2

[]

[ "IPR056728" ]

0

1

0

[ "Bacteria", "Eukaryota", "Methanobacteriota", "unclassified sequences" ]

[ 8226, 1491, 130, 131 ]

4

[ "Arabidopsis thaliana", "Escherichia coli (strain K12)", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 2, 1, 3, 2 ]

4

true

Family

UPF0014 family

UPF0014_fam

8

IPR005227

5,227

Putative pre-16S rRNA nuclease

YqgF

Family

26,654

false

This entry represents a group of predicted nucleases involved in processing of the 5'-end of pre-16S rRNA. This entry typified by the Escherichia coli protein YqgF, which exhibits an RNAse H fold in crystal structure and is involved in the processing of pre-16S rRNA during ribosome maturation [ ].

[ "GO:0006364" ]

[ "rRNA processing" ]

[ "biological_process" ]

1

[ "HAMAP", "PFAM", "PANTHER", "NCBIFAM", "CDD" ]

[ "MF_00651", "PF03652", "PTHR33317", "TIGR00250", "cd16964" ]

[ "Nuclease_YqgF", "RuvX", "", "RNAse_H_YqgF", "YqgF" ]

[ 25275, 26529, 26088, 25292, 25778 ]

5

[]

0

[ "1iv0", "1nmn", "1nu0", "1ovq", "1vhx", "7ess", "7w89" ]

7

[ "PUB00076429" ]

[ "25545592" ]

[ "Novel essential gene Involved in 16S rRNA processing in Escherichia coli." ]

[ 2015 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 24357, 1692, 605 ]

3

[ "Arabidopsis thaliana", "Escherichia coli (strain K12)", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 9, 1, 5, 15 ]

4

true

Family

Putative pre-16S rRNA nuclease

YqgF

5

IPR005230

5,230

TraB, bacterial/archaeal

TraB_bac

Family

1,978

false

In prokaryotes, for example Enterococcus faecalis (Streptococcus faecalis), the conjugative transfer of certain plasmids is controlled by peptide pheromones [ ]. Plasmid free recipient cells secret plasmid specific oligopeptides, termed sex pheromones. They induce bacterial clumping and specifically activate the conjug...

[]

0

[ "NCBIFAM" ]

[ "TIGR00261" ]

[ "traB" ]

[ 1978 ]

1

[]

0

[]

0

[ "PUB00035674", "PUB00035675", "PUB00035676", "PUB00035677", "PUB00035678", "PUB00095434" ]

[ "15374642", "7559344", "1924555", "8349565", "7772836", "23673329" ]

[ "Enterococcal peptide sex pheromones: synthesis and control of biological activity.", "Cloning and characterization of a region of Enterococcus faecalis plasmid pPD1 encoding pheromone inhibitor (ipd), pheromone sensitivity (traC), and pheromone shutdown (traB) genes.", "Control of Enterococcus faecalis sex phe...

[ 2004, 1995, 1991, 1993, 1995, 2013 ]

6

[ "IPR046345" ]

[]

1

0

1

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 305, 1622, 3, 48 ]

4

[]

0

true

Family

TraB, bacterial/archaeal

TraB_bac

1

IPR005231

5,231

Nascent polypeptide-associated complex (NAC), archaeal

NAC_arc

Family

944

false

Eukaryotic NAC, an abundant heterodimer composed of two homologous subunits, reversibly binds eukaryotic ribosomes and is located in direct proximity to nascent polypeptides as they emerge from the ribosome [ ]. Despite being implicated in diverse cellular functions, its role in vivo is still not completely understood....

[ "GO:0003723" ]

[ "RNA binding" ]

[ "molecular_function" ]

1

[ "HAMAP", "NCBIFAM" ]

[ "MF_00814", "TIGR00264" ]

[ "NAC_arch", "" ]

[ 892, 943 ]

2

[]

0

[ "1tr8" ]

1

[ "PUB00031550", "PUB00033736" ]

[ "15665334", "12475173" ]

[ "The crystal structure of archaeal nascent polypeptide-associated complex (NAC) reveals a unique fold and the presence of a ubiquitin-associated domain.", "Nascent-polypeptide-associated complex." ]

[ 2005, 2002 ]

2

[]

0

null

[ "Archaea", "Geodia barretti", "candidate division WOR-3 bacterium", "unclassified sequences" ]

[ 907, 1, 1, 35 ]

4

[]

0

true

Family

Nascent polypeptide-associated complex (NAC), archaeal

NAC_arc

5

IPR005232

5,232

Pyridinium-3,5-bisthiocarboxylic acid mononucleotide synthase LarE-like

LarE-like

Family

4,696

false

This family includes Pyridinium-3,5-bisthiocarboxylic acid mononucleotide synthase (LarE), one of three accessory proteins (the others being LarB and LarC) present in the lactate racemisation operon larA-E. This entry also includes Uncharacterized protein slr1717 and MJ0830. Proteins in this entry are found in prokaryo...

[ "GO:0016783" ]

[ "sulfurtransferase activity" ]

[ "molecular_function" ]

1

[ "PIRSF", "NCBIFAM", "CDD" ]

[ "PIRSF006661", "TIGR00268", "cd01990" ]

[ "PP-lp_UCP006661", "", "LarE-like" ]

[ 4376, 4306, 4296 ]

3

[]

0

[ "5udq", "5udr", "5uds", "5udt", "5udu", "5udv", "5udw", "5udx", "5unm", "6b2m", "6b2o", "6dg3", "6utp", "6utq", "6utr", "6utt", "8cnz", "8cp3", "8cp4" ]

19

[ "PUB00085157", "PUB00086644" ]

[ "24710389", "27114550" ]

[ "Lactate racemase is a nickel-dependent enzyme activated by a widespread maturation system.", "Nickel-pincer cofactor biosynthesis involves LarB-catalyzed pyridinium carboxylation and LarE-dependent sacrificial sulfur insertion." ]

[ 2014, 2016 ]

2

[ "IPR052188" ]

[]

1

0

1

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 644, 3772, 126, 154 ]

4

[]

0

true

Family

Pyridinium-3,5-bisthiocarboxylic acid mononucleotide synthase LarE-like

LarE-like

5

IPR005234

5,234

Chromosome segregation/condensation protein ScpB

ScpB_csome_segregation

Family

21,182

false

This family represents ScpB, which along with ScpA ( ) interacts with SMC in vivo forming a complex that is required for chromosome condensation and segregation [ , ]. The SMC-Scp complex appears to be similar to the MukB-MukE-Muk-F complex in Escherichia coli [ ], where MukB ( ) is the homologue of SMC. ScpA and ScpB ...

[ "GO:0051304" ]

[ "chromosome separation" ]

[ "biological_process" ]

1

[ "HAMAP", "PFAM", "PIRSF", "PANTHER", "NCBIFAM" ]

[ "MF_01804", "PF04079", "PIRSF019345", "PTHR34298", "TIGR00281" ]

[ "ScpB", "SMC_ScpB", "ScpB", "", "" ]

[ 4175, 21182, 13308, 21114, 19146 ]

5

[ "GP" ]

[ "GenProp0201" ]

[ "GP:GenProp0201" ]

1

[ "1t6s", "2z99", "3w6j", "3w6k", "4i98", "6juv" ]

6

[ "PUB00015249", "PUB00015250", "PUB00015251", "PUB00015252" ]

[ "12065423", "12897137", "10545099", "12100548" ]

[ "Cell cycle-dependent localization of two novel prokaryotic chromosome segregation and condensation proteins in Bacillus subtilis that interact with SMC protein.", "A prokaryotic condensin/cohesin-like complex can actively compact chromosomes from a single position on the nucleoid and binds to DNA as a ring-like ...

[ 2002, 2003, 1999, 2002 ]

4

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 330, 20330, 25, 497 ]

4

[]

0

true

Family

Chromosome segregation/condensation protein ScpB

ScpB_csome_segregation

5

IPR005235

5,235

Metallophosphoesterase, YmdB-like

YmdB-like

Family

7,402

false

This family of putative phosphoesterases contains the characterised B. subtilis protein 2',3'-cyclic-nucleotide 2'-phosphodiesterase (previously known as YmdB). 2',3'-cyclic-nucleotide 2'-phosphodiesterase has been shown to be essential for biofilm formation and to be a global regulator of late adaptive responses [ ]. ...

[]

0

[ "PFAM", "PIRSF", "PANTHER", "NCBIFAM" ]

[ "PF13277", "PIRSF004789", "PTHR36303", "TIGR00282" ]

[ "YmdB", "DR1281", "", "" ]

[ 7402, 7048, 7378, 5292 ]

4

[]

0

[ "1t70", "1t71", "2cv9", "2z06", "4b2o" ]

5

[ "PUB00046671", "PUB00084998" ]

[ "17847097", "24163345" ]

[ "Structural and enzymatic characterization of DR1281: A calcineurin-like phosphoesterase from Deinococcus radiodurans.", "The YmdB phosphodiesterase is a global regulator of late adaptive responses in Bacillus subtilis." ]

[ 2008, 2014 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 7164, 40, 198 ]

3

[]

0

true

Family

Metallophosphoesterase, YmdB-like

YmdB-like

6

IPR005236

5,236

Dihydropteroate synthase-related protein synthase-related protein

Dihydropt_synth

Family

379

false

The proteins of this family have been found so far only in the four archaeal species. The central region of the proteins shows considerable homology to the amino-terminal half of dihydropteroate synthases.

[]

0

[ "NCBIFAM" ]

[ "TIGR00284" ]

[ "" ]

[ 379 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "ecological metagenomes" ]

[ 374, 5 ]

2

[]

0

true

Family

Dihydropteroate synthase-related protein synthase-related protein

Dihydropt_synth

9

IPR005237

5,237

Uncharacterised protein MJ0570

MJ0570

Family

206

false

This family of conserved hypothetical proteins has no known function. Homologous proteins related to MJ0570 of Methanocaldococcus jannaschii (Methanococcus jannaschii) include both the apparent orthologs in the family, the much longer protein YLR143W from Saccharomyces cerevisiae (Baker's yeast), and second homologous ...

[]

0

[ "NCBIFAM" ]

[ "TIGR00289" ]

[ "" ]

[ 206 ]

1

[]

0

[ "2d13", "3rjz", "3rk0", "3rk1" ]

4

[]

0

[ "IPR022427" ]

[]

1

0

1

[ "Archaea", "ecological metagenomes" ]

[ 204, 2 ]

2

[]

0

true

Family

Uncharacterised protein MJ0570

MJ0570

2

IPR005239

5,239

Bifunctional arginine dihydrolase/ornithine cyclodeaminase ArgZ/ArgE-like

ArgZ/ArgE-like

Family

1,038

false

This entry includes the bifunctional arginine dihydrolase/ornithine cyclodeaminase ArgZ (also known as as Sll1336), ArgE from Synechocystis sp and similar prokaryotic sequences. ArgZ is involved in an ornithine-ammonia cycle (OAC) in cyanobacteria, which confers substantial adaptability under environmental nitrogen flu...

[]

0

[ "NCBIFAM" ]

[ "TIGR00300" ]

[ "" ]

[ 1038 ]

1

[ "EC", "METACYC" ]

[ "4.3.1.12", "PWY-4981" ]

[ "EC:4.3.1.12", "METACYC:PWY-4981" ]

2

[ "3c2q", "6juy", "6lrf", "6lrg", "6lrh" ]

5

[ "PUB00151841" ]

[ "31914412" ]

[ "Crystal structures and biochemical analyses of the bacterial arginine dihydrolase ArgZ suggests a \"bond rotation\" catalytic mechanism." ]

[ 2020 ]

1

[]

0

null

[ "Archaea", "Bacteria", "metagenomes" ]

[ 432, 585, 21 ]

3

[]

0

true

Family

Bifunctional arginine dihydrolase/ornithine cyclodeaminase ArgZ/ArgE-like

ArgZ/ArgE-like

7

IPR005240

5,240

Protein of unknown function DUF389

DUF389

Family

9,298

false

This family of conserved hypothetical proteins has no known function. It includes potential integral membrane proteins.

[]

0

[ "PFAM", "PANTHER" ]

[ "PF04087", "PTHR20992" ]

[ "DUF389", "" ]

[ 9160, 9211 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Megaviricetes", "metagenomes" ]

[ 1027, 7051, 1123, 2, 95 ]

5

[ "Drosophila melanogaster" ]

[ 16 ]

1

true

Family

Protein of unknown function DUF389

DUF389

7

IPR005245

5,245

Conserved hypothetical protein CHP00454

CHP00454

Family

40

false

This entry describes a family of conserved hypothetical proteins with no known function.

[]

0

[ "NCBIFAM" ]

[ "TIGR00454" ]

[ "" ]

[ 40 ]

1

[]

0

[ "2mzb", "3rsb" ]

2

[]

0

[]

0

null

[ "Methanobacteriota" ]

[ 40 ]

1

[]

0

true

Family

Conserved hypothetical protein CHP00454

CHP00454

1

IPR005246

5,246

O-phosphoseryl-tRNA(Cys) ligase

O-Pseryl-tRNA(Cys)_ligase

Family

259

false

This entry represents archaeal phenylalanyl-tRNA ligase alpha chains. It was shown to act in a proposed pathway of tRNA(Cys) indirect aminoacylation, resulting in Cys biosynthesis from O-phosphoserine, in certain archaea. It charges tRNA(Cys) with O-phosphoserine. The pscS gene product converts the phosphoserine to Cys...

[ "GO:0004812", "GO:0005524", "GO:0043039" ]

[ "aminoacyl-tRNA ligase activity", "ATP binding", "tRNA aminoacylation" ]

[ "molecular_function", "molecular_function", "biological_process" ]

3

[ "HAMAP", "NCBIFAM" ]

[ "MF_01674", "TIGR00470" ]

[ "Sep_tRNA_synth", "sepS" ]

[ 223, 259 ]

2

[ "EC", "GP", "METACYC" ]

[ "6.1.1.27", "GenProp0304", "PWY-6308" ]

[ "EC:6.1.1.27", "GP:GenProp0304", "METACYC:PWY-6308" ]

3

[ "2du3", "2du4", "2du5", "2du6", "2du7", "2odr", "5x6c" ]

7

[ "PUB00020741" ]

[ "15790858" ]

[ "RNA-dependent cysteine biosynthesis in archaea." ]

[ 2005 ]

1

[]

0

null

[ "Archaea", "ecological metagenomes" ]

[ 252, 7 ]

2

[]

0

true

Family

O-phosphoseryl-tRNA(Cys) ligase

O-Pseryl-tRNA(Cys)_ligase

5

IPR005247

5,247

YbhB/YbcL/LppC-like

YbhB_YbcL/LppC-like

Family

18,235

false

This family contains Escherichia coli YbhB and YbcL, two bacterial homologues to Raf kinase inhibitor proteins from mammals (RKIP, previously known as PEBP), according to structural similarity. YbhB and YbcL have specific features, for example a substrate binding pocket formed by the dimerization interface and the abse...

[]

0

[ "NCBIFAM", "CDD" ]

[ "TIGR00481", "cd00865" ]

[ "", "PEBP_bact_arch" ]

[ 17249, 18199 ]

2

[]

0

[ "1fjj", "1fux", "1vi3", "2evv", "3n08", "4beg" ]

6

[ "PUB00015041", "PUB00106497", "PUB00135086" ]

[ "11439028", "25183735", "25041568" ]

[ "Crystal structures of YBHB and YBCL from Escherichia coli, two bacterial homologues to a Raf kinase inhibitor protein.", "Bacterial lysis liberates the neutrophil migration suppressor YbcL from the periplasm of uropathogenic Escherichia coli.", "Specific interaction between Mycobacterium tuberculosis lipoprote...

[ 2001, 2014, 2014 ]

3

[ "IPR008914" ]

[]

1

0

1

[ "Archaea", "Bacteria", "Eukaryota", "Klosneuvirinae", "unclassified sequences" ]

[ 678, 16772, 581, 3, 201 ]

5

[ "Arabidopsis thaliana", "Escherichia coli (strain K12)", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 5, 2, 3, 4 ]

4

true

Family

YbhB/YbcL/LppC-like

YbhB_YbcL/LppC-like

4

IPR005248

5,248

Nicotinate/nicotinamide nucleotide adenylyltransferase

NadD/NMNAT

Family

30,895

false

This family contains the adenylyltransferases for nicotinamide-nucleotide and for the deamido form, nicotinate nucleotide found predominantly in bacteria and fungi. Nicotinamide-nucleotide adenylyltransferase (NMNAT, ) [ ] synthesizes NAD by the salvage pathway, while nicotinate-nucleotide adenylyltransferase (NaMN-ATa...

[ "GO:0016779", "GO:0009435" ]

[ "nucleotidyltransferase activity", "NAD+ biosynthetic process" ]

[ "molecular_function", "biological_process" ]

2

[ "HAMAP", "PANTHER", "NCBIFAM", "CDD" ]

[ "MF_00244", "PTHR39321", "TIGR00482", "cd02165" ]

[ "NaMN_adenylyltr", "", "", "NMNAT" ]

[ 23858, 25266, 27517, 25499 ]

4

[ "EC", "GP", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "2.7.7.18", "GenProp0057", "PWY-5381", "PWY-5653", "PWY-7761", "PWY-8277", "PWY-8352", "R-BTA-196807", "R-CEL-196807", "R-DME-196807", "R-HSA-196807", "R-MMU-196807", "R-SCE-196807", "R-SPO-196807" ]

[ "EC:2.7.7.18", "GP:GenProp0057", "METACYC:PWY-5381", "METACYC:PWY-5653", "METACYC:PWY-7761", "METACYC:PWY-8277", "METACYC:PWY-8352", "REACTOME:R-BTA-196807", "REACTOME:R-CEL-196807", "REACTOME:R-DME-196807", "REACTOME:R-HSA-196807", "REACTOME:R-MMU-196807", "REACTOME:R-SCE-196807", "REACTO...

14

[ "1gzu", "1k4k", "1k4m", "1kam", "1kaq", "1kku", "1kqn", "1kqo", "1kr2", "1nup", "1nuq", "1nur", "1nus", "1nut", "1nuu", "1yul", "1yum", "1yun", "2h29", "2h2a", "2qtm", "2qtn", "2qtr", "3dv2", "3e27", "3h05", "3hfj", "3mla", "3mlb", "3mmx", "4rpi", "4s1o"...

53

[ "PUB00083163", "PUB00083164" ]

[ "17402747", "10894752" ]

[ "Initial-rate kinetics of human NMN-adenylyltransferases: substrate and metal ion specificity, inhibition by products and multisubstrate analogues, and isozyme contributions to NAD+ biosynthesis.", "Identification of the Escherichia coli nicotinic acid mononucleotide adenylyltransferase gene." ]

[ 2007, 2000 ]

2

[]

[ "IPR045094" ]

0

1

0

[ "Bacteria", "Candidatus Iainarchaeum sp.", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 24580, 1, 5703, 16, 595 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus",...

[ 2, 2, 2, 1, 1, 4, 5, 1, 1, 9, 3, 2, 3 ]

13

true

Family

Nicotinate/nicotinamide nucleotide adenylyltransferase

NadD/NMNAT

6

IPR005249

5,249

Ap4A hydrolase

YqeK

Family

6,562

false

This entry represents Bis(5'-nucleosyl)-tetraphosphatase, symmetrical from Staphylococcus aureus (YqeK, also known as Ap4A hydrolase) and similar bacterial proteins. YqeK functions as a hydrolase of diadenosine tetraphosphate (Ap4A), cleaving symmetrically to yield two molecules of ADP [ ].

[]

0

[ "NCBIFAM" ]

[ "TIGR00488" ]

[ "" ]

[ 6562 ]

1

[ "EC" ]

[ "3.6.1.41" ]

[ "EC:3.6.1.41" ]

1

[ "2o08", "2ogi", "3ccg", "8jja", "8jjk", "8jk5", "8jk8", "8jk9", "8jka", "8jkp", "8jkr", "8wmy", "8yt5" ]

13

[ "PUB00100276" ]

[ "32152217" ]

[ "Functional Characterization of COG1713 (YqeK) as a Novel Diadenosine Tetraphosphate Hydrolase Family." ]

[ 2020 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 6507, 3, 52 ]

3

[]

0

true

Family

Ap4A hydrolase

YqeK

9

IPR005250

5,250

Ribose-1,5-bisphosphate isomerase

R15Pi

Family

465

false

The delineation of this family was based originally, in part, on a discussion and neighbour-joining phylogenetic study [ ] of archaeal and other proteins homologous to the alpha, beta, and delta subunits of eukaryotic initiation factor 2B (eIF-2B), a five-subunit molecule that catalyses GTP recycling for eIF-2 [ ]. Lat...

[ "GO:0043917" ]

[ "ribose 1,5-bisphosphate isomerase activity" ]

[ "molecular_function" ]

1

[ "HAMAP", "NCBIFAM" ]

[ "MF_02230", "TIGR00511" ]

[ "R15P_isomerase", "ribulose_e2b2" ]

[ 428, 465 ]

2

[ "EC", "GP", "METACYC", "METACYC" ]

[ "5.3.1.29", "GenProp0728", "PWY-5532", "PWY-8440" ]

[ "EC:5.3.1.29", "GP:GenProp0728", "METACYC:PWY-5532", "METACYC:PWY-8440" ]

4

[ "3a11", "3a9c", "3vm6", "5yfj", "5yfs", "5yft", "5yfu", "5yfv", "5yfw", "5yfx", "5yg5", "5yg6", "5yg7", "5yg8", "5yg9", "5yga" ]

16

[ "PUB00004919", "PUB00042999", "PUB00094467" ]

[ "9520434", "17303759", "22511789" ]

[ "Archaeal translation initiation revisited: the initiation factor 2 and eukaryotic initiation factor 2B alpha-beta-delta subunit families.", "Archaeal type III RuBisCOs function in a pathway for AMP metabolism.", "Dynamic, ligand-dependent conformational change triggers reaction of ribose-1,5-bisphosphate isome...

[ 1998, 2007, 2012 ]

3

[ "IPR011559" ]

[]

1

0

1

[ "Archaea", "Unknown prokaryotic organism", "unclassified sequences" ]

[ 458, 1, 6 ]

3

[]

0

true

Family

Ribose-1,5-bisphosphate isomerase

R15Pi

6

IPR005251

5,251

Methylthioribose-1-phosphate isomerase

IF-M1Pi

Family

13,491

false

This family contains proteins designated as 5-methylthioribose-1-phosphate isomerase (MTNA, , [ ]). It also contains putative translation initiation factor 2B subunit proteins. 5-methylthioribose-1-phosphate isomerase (MTNA) participates in the methionine salvage pathway catalysing the isomerisation of 5-methylthioribo...

[]

0

[ "HAMAP", "NCBIFAM" ]

[ "MF_01678", "TIGR00512" ]

[ "Salvage_MtnA", "salvage_mtnA" ]

[ 12850, 13423 ]

2

[ "EC", "GP", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "5.3.1.23", "GenProp0729", "PWY-4361", "PWY-7174", "PWY-8130", "PWY-8131", "PWY-8132", "R-CEL-1237112", "R-DME-1237112", "R-DRE-1237112", "R-HSA-1237112", "R-MMU-1237112", "R-RNO-1237112", "R-SCE-1237112", "R-SPO-1237112", "R-XTR-1237112" ]

[ "EC:5.3.1.23", "GP:GenProp0729", "METACYC:PWY-4361", "METACYC:PWY-7174", "METACYC:PWY-8130", "METACYC:PWY-8131", "METACYC:PWY-8132", "REACTOME:R-CEL-1237112", "REACTOME:R-DME-1237112", "REACTOME:R-DRE-1237112", "REACTOME:R-HSA-1237112", "REACTOME:R-MMU-1237112", "REACTOME:R-RNO-1237112", "...

16

[ "1t5o", "1t9k", "2a0u", "2yrf", "2yvk", "4ldq", "4ldr", "6a34", "6a35" ]

9

[ "PUB00004919", "PUB00016714", "PUB00016716", "PUB00016925" ]

[ "9520434", "15215245", "14551435", "9419357" ]

[ "Archaeal translation initiation revisited: the initiation factor 2 and eukaryotic initiation factor 2B alpha-beta-delta subunit families.", "Crystal structure of yeast Ypr118w, a methylthioribose-1-phosphate isomerase related to regulatory eIF2B subunits.", "A functional link between RuBisCO-like protein of Ba...

[ 1998, 2004, 2003, 1998 ]

4

[ "IPR011559" ]

[ "IPR043679" ]

1

0

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 520, 9135, 3622, 214 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 5, 1, 1, 1, 1, 2, 1, 2, 4, 1, 1, 4 ]

12

true

Family

Methylthioribose-1-phosphate isomerase

IF-M1Pi

2

IPR005252

5,252

Coenzyme A biosynthesis bifunctional protein CoaBC

CoaBC

Family

24,134

false

This entry represents a bifunctional enzyme CoaBC (gene name dfp) that catalyses the second and third steps (cysteine ligation, ( ), and decarboxylation, ( )) in the biosynthesis of coenzyme A (CoA) from pantothenate in bacteria. This enzyme contains the FMN cofactor, but no FAD or pyruvoyl group. The amino-terminal re...

[ "GO:0004632", "GO:0004633", "GO:0010181", "GO:0015937", "GO:0015941" ]

[ "phosphopantothenate--cysteine ligase activity", "phosphopantothenoylcysteine decarboxylase activity", "FMN binding", "coenzyme A biosynthetic process", "pantothenate catabolic process" ]

[ "molecular_function", "molecular_function", "molecular_function", "biological_process", "biological_process" ]

5

[ "HAMAP", "NCBIFAM" ]

[ "MF_02225", "TIGR00521" ]

[ "CoaBC", "coaBC_dfp" ]

[ 23501, 23545 ]

2

[ "EC", "EC", "GP", "GP", "METACYC", "METACYC" ]

[ "4.1.1.36", "6.3.2.5", "GenProp0171", "GenProp1601", "PWY-7851", "PWY-8342" ]

[ "EC:4.1.1.36", "EC:6.3.2.5", "GP:GenProp0171", "GP:GenProp1601", "METACYC:PWY-7851", "METACYC:PWY-8342" ]

6

[ "1u7u", "1u7w", "1u7z", "1u80", "5int", "6tgv" ]

6

[ "PUB00015483", "PUB00015610", "PUB00060434" ]

[ "11278255", "3123465", "2999089" ]

[ "Phosphopantothenoylcysteine synthetase from Escherichia coli. Identification and characterization of the last unidentified coenzyme A biosynthetic enzyme in bacteria.", "beta-Alanine auxotrophy associated with dfp, a locus affecting DNA synthesis in Escherichia coli.", "dfp Gene of Escherichia coli K-12, a loc...

[ 2001, 1988, 1985 ]

3

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified Caudoviricetes", "unclassified sequences" ]

[ 844, 22750, 52, 2, 486 ]

5

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Coenzyme A biosynthesis bifunctional protein CoaBC

CoaBC

7

IPR005253

5,253

Conserved hypothetical protein CHP00529

CHP00529

Family

31

false

This protein is predicted to have 10 transmembrane regions. Members of this family are found so far in the Archaea (Archaeoglobus fulgidus and Pyrococcus horikoshii) and in a bacterial thermophile, Thermotoga maritima. In Pyrococcus, the gene is located between nadA and nadB, two components of an enzyme involved in de ...

[]

0

[ "NCBIFAM" ]

[ "TIGR00529" ]

[ "AF0261" ]

[ 31 ]

1

[]

0

[]

0

[]

0

[ "IPR007294" ]

[]

1

0

1

[ "Methanobacteriota", "Thermotoga" ]

[ 26, 5 ]

2

[]

0

true

Family

Conserved hypothetical protein CHP00529

CHP00529

3

IPR005254

5,254

Heme biosynthesis-associated TPR protein

Heme_biosyn_assoc_TPR_pro

Family

6,080

false

This is a family of uncharacterised tetratricopeptide repeat (TPR) proteins invariably found in heme biosynthesis gene clusters. The absence of any invariant residues other than Ala argues against this protein serving as an enzyme per se. The gene symbol hemY assigned in E. coli is unfortunate in that an unrelated prot...

[ "GO:0042168", "GO:0016020" ]

[ "heme metabolic process", "membrane" ]

[ "biological_process", "cellular_component" ]

2

[ "NCBIFAM" ]

[ "TIGR00540" ]

[ "TPR_hemY_coli" ]

[ 6080 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 6010, 6, 64 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Heme biosynthesis-associated TPR protein

Heme_biosyn_assoc_TPR_pro

3

IPR005255

5,255

PdxA family

PdxA_fam

Family

20,432

false

This entry represents the PdxA family. PdxA is an NAD+-dependent 4-hydroxythreonine 4-phosphate dehydrogenase ( ) active in pyridoxal phosphate biosynthesis [ ]. PdxA2, a functional paralogue of PdxA, catalyzes the NAD-dependent oxidation and subsequent decarboxylation of D-erythronate 4-phosphate to produce dihydroxya...

[ "GO:0051287" ]

[ "NAD binding" ]

[ "molecular_function" ]

1

[ "PFAM", "PANTHER", "NCBIFAM" ]

[ "PF04166", "PTHR30004", "TIGR00557" ]

[ "PdxA", "", "pdxA" ]

[ 20409, 20391, 17729 ]

3

[ "EC", "GP", "GP" ]

[ "1.1.1.262", "GenProp0862", "GenProp1633" ]

[ "EC:1.1.1.262", "GP:GenProp0862", "GP:GenProp1633" ]

3

[ "1ps6", "1ps7", "1ptm", "1r8k", "1yxo", "2hi1", "3lxy", "3tsn", "4aty", "4jqp", "6e85", "6xmy", "8zhy", "8zi8", "8zin", "8zj0", "8zj3", "8zj5", "8zj7" ]

19

[ "PUB00022460", "PUB00083215", "PUB00085179", "PUB00085180" ]

[ "12896974", "27294475", "27402745", "16517628" ]

[ "Crystal structure of Escherichia coli PdxA, an enzyme involved in the pyridoxal phosphate biosynthesis pathway.", "Members of a Novel Kinase Family (DUF1537) Can Recycle Toxic Intermediates into an Essential Metabolite.", "Assignment of function to a domain of unknown function: DUF1537 is a new kinase family i...

[ 2003, 2016, 2016, 2006 ]

4

[]

[ "IPR037510", "IPR037539" ]

0

2

0

[ "Archaea", "Bacteria", "Eukaryota", "Siphoviridae sp. ctBLh2", "unclassified sequences" ]

[ 89, 19777, 127, 1, 438 ]

5

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

PdxA family

PdxA_fam

3

IPR005257

5,257

Anthranilate synthase component I, TrpE-like, bacterial

Anth_synth_I_TrpE

Family

3,147

false

This family represents anthranilate/para-aminobenzoate synthase component I from proteobacteria and actinobacteria.

[ "GO:0004049", "GO:0009058" ]

[ "anthranilate synthase activity", "biosynthetic process" ]

[ "molecular_function", "biological_process" ]

2

[ "PIRSF", "NCBIFAM" ]

[ "PIRSF001373", "TIGR00565" ]

[ "TrpE", "trpE_proteo" ]

[ 2960, 3144 ]

2

[ "EC", "GP", "GP", "GP", "GP", "METACYC", "METACYC" ]

[ "4.1.3.27", "GenProp0037", "GenProp1450", "GenProp1538", "GenProp1550", "PWY-5958", "PWY-6661" ]

[ "EC:4.1.3.27", "GP:GenProp0037", "GP:GenProp1450", "GP:GenProp1538", "GP:GenProp1550", "METACYC:PWY-5958", "METACYC:PWY-6661" ]

7

[ "1i1q", "1i7q", "1i7s" ]

3

[]

0

[ "IPR019999" ]

[]

1

0

1

[ "Bacteria", "Opisthokonta", "ecological metagenomes" ]

[ 3141, 4, 2 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Anthranilate synthase component I, TrpE-like, bacterial

Anth_synth_I_TrpE

8

IPR005259

5,259

Primosomal protein N'

PriA

Family

25,166

false

This entry represents primosomal protein N' (PriA) proteins found mainly in bacterial organisms. Primosomal protein N', also known as ATP-dependent helicase PriA, is a component of the primosome, which is involved in replication, repair, and recombination. PriA serves as a sensor/stabiliser for an arrested replication ...

[ "GO:0003677", "GO:0003678", "GO:0006260", "GO:0006302", "GO:0006310" ]

[ "DNA binding", "DNA helicase activity", "DNA replication", "double-strand break repair", "DNA recombination" ]

[ "molecular_function", "molecular_function", "biological_process", "biological_process", "biological_process" ]

5

[ "HAMAP", "NCBIFAM" ]

[ "MF_00983", "TIGR00595" ]

[ "PriA", "priA" ]

[ 24586, 21334 ]

2

[ "EC", "GP", "GP", "GP" ]

[ "5.6.2.4", "GenProp1081", "GenProp1130", "GenProp1187" ]

[ "EC:5.6.2.4", "GP:GenProp1081", "GP:GenProp1130", "GP:GenProp1187" ]

4

[ "4nl4", "4nl8", "6dcr", "6dgd", "8fak" ]

5

[ "PUB00074159", "PUB00074160" ]

[ "17483094", "23264623" ]

[ "Escherichia coli PriA protein, two modes of DNA binding and activation of ATP hydrolysis.", "The PriA replication restart protein blocks replicase access prior to helicase assembly and directs template specificity through its ATPase activity." ]

[ 2007, 2013 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "Siphoviridae sp. ctBLh2", "Thermoproteati", "unclassified sequences" ]

[ 24788, 40, 1, 2, 335 ]

5

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Primosomal protein N'

PriA

6

IPR005260

5,260

Aspartate kinase, monofunctional class

Asp_kin_monofn

Family

28,667

false

This entry describes a subclass of the aspartate kinases that are mostly Lys-sensitive and are not fused to homoserine dehydrogenase. The E. coli enzyme is a homodimer, while the Bacillus and Corynebacterium enzymes are alpha 2/beta 2 heterotetramers, where the beta subunit is translated from an in-phase alternative in...

[ "GO:0004072", "GO:0009089" ]

[ "aspartate kinase activity", "L-lysine biosynthetic process via diaminopimelate" ]

[ "molecular_function", "biological_process" ]

2

[ "PIRSF", "NCBIFAM" ]

[ "PIRSF000726", "TIGR00656" ]

[ "Asp_kin", "asp_kin_monofn" ]

[ 28245, 16782 ]

2

[ "EC", "GP", "GP", "GP", "GP", "GP", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC" ]

[ "2.7.2.4", "GenProp0160", "GenProp1250", "GenProp1358", "GenProp1419", "GenProp1553", "PWY-2941", "PWY-2942", "PWY-5097", "PWY-6160", "PWY-6559", "PWY-6562", "PWY-7153", "PWY-7977", "PWY-8088", "PWY-8179", "PWY-8296" ]

[ "EC:2.7.2.4", "GP:GenProp0160", "GP:GenProp1250", "GP:GenProp1358", "GP:GenProp1419", "GP:GenProp1553", "METACYC:PWY-2941", "METACYC:PWY-2942", "METACYC:PWY-5097", "METACYC:PWY-6160", "METACYC:PWY-6559", "METACYC:PWY-6562", "METACYC:PWY-7153", "METACYC:PWY-7977", "METACYC:PWY-8088", "M...

17

[ "2cdq", "2hmf", "2j0w", "2j0x", "3aaw", "3ab2", "3ab4", "3c1m", "3c1n", "3c20", "3l76", "3tvi", "5yei" ]

13

[ "PUB00006443", "PUB00033949", "PUB00033950" ]

[ "10220897", "2168395", "8100567" ]

[ "Mutational analysis of the feedback sites of lysine-sensitive aspartokinase of Escherichia coli.", "Aspartokinase II from Bacillus subtilis is degraded in response to nutrient limitation.", "Gene structure and expression of the Corynebacterium flavum N13 ask-asd operon." ]

[ 1999, 1990, 1993 ]

3

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 601, 26753, 954, 2, 357 ]

5

[ "Arabidopsis thaliana", "Escherichia coli (strain K12)", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 2, 1, 1, 3 ]

4

true

Family

Aspartate kinase, monofunctional class

Asp_kin_monofn

7

IPR005261

5,261

Inner membrane protein YohK-like

YohK-like

Family

1,747

false

Members of this small but broadly distibuted (Gram-positive, Gram-negative, and Archaeal) family appear to have multiple transmembrane segments. The function is unknown.

[]

0

[ "NCBIFAM" ]

[ "TIGR00659" ]

[ "" ]

[ 1747 ]

1

[]

0

[]

0

[]

0

[ "IPR007300" ]

[]

1

0

1

[ "Archaea", "Bacteria", "Eukaryota", "uncultured organism" ]

[ 42, 1702, 2, 1 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Inner membrane protein YohK-like

YohK-like

6

IPR005262

5,262

MJ1255-like

Domain

1,159

false

The function of this domain is unknown. A small region (~50 amino acids) within the domain appears to be related to a family of sugar transferases.

[]

0

[ "NCBIFAM" ]

[ "TIGR00661" ]

[ "MJ1255" ]

[ 1159 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Methanobacteriati", "ecological metagenomes" ]

[ 1066, 90, 3 ]

3

[]

0

true

Domain

MJ1255-like

3

IPR005263

5,263

4-hydroxy-tetrahydrodipicolinate synthase, DapA

DapA

Family

32,621

false

4-hydroxy-tetrahydrodipicolinate synthase dapA is a homotetrameric enzyme of lysine biosynthesis. It catalyses the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA) [ ]. E. coli has several paralogs closely related to dihydrodipicoline synthase, as well as...

[ "GO:0008840", "GO:0009089" ]

[ "4-hydroxy-tetrahydrodipicolinate synthase activity", "L-lysine biosynthetic process via diaminopimelate" ]

[ "molecular_function", "biological_process" ]

2

[ "HAMAP", "NCBIFAM", "CDD" ]

[ "MF_00418", "TIGR00674", "cd00950" ]

[ "DapA", "dapA", "DHDPS" ]

[ 30545, 31881, 30096 ]

3

[ "EC", "GP", "GP", "METACYC", "METACYC", "METACYC", "METACYC" ]

[ "4.3.3.7", "GenProp0125", "GenProp0788", "PWY-2941", "PWY-2942", "PWY-5097", "PWY-8088" ]

[ "EC:4.3.3.7", "GP:GenProp0125", "GP:GenProp0788", "METACYC:PWY-2941", "METACYC:PWY-2942", "METACYC:PWY-5097", "METACYC:PWY-8088" ]

7

[ "1dhp", "1o5k", "1s5t", "1s5v", "1s5w", "1xky", "1xl9", "1xxx", "1yxc", "1yxd", "2a6l", "2a6n", "2ats", "2ehh", "2ojp", "2pur", "2rfg", "2vc6", "2yxg", "3a5f", "3c0j", "3cpr", "3daq", "3den", "3di0", "3di1", "3du0", "3flu", "3g0s", "3hij", "3i7q", "3i7r"...

146

[ "PUB00003343", "PUB00014558", "PUB00030924" ]

[ "7853400", "9559056", "15066435" ]

[ "The crystal structure of dihydrodipicolinate synthase from Escherichia coli at 2.5 A resolution.", "Enzymology of bacterial lysine biosynthesis.", "The crystal structure of three site-directed mutants of Escherichia coli dihydrodipicolinate synthase: further evidence for a catalytic triad." ]

[ 1995, 1998, 2004 ]

3

[ "IPR002220" ]

[ "IPR012691" ]

1

0

[ "Archaea", "Bacteria", "Eukaryota", "Megaviridae environmental sample", "unclassified sequences" ]

[ 632, 30156, 1339, 1, 493 ]

5

[ "Arabidopsis thaliana", "Escherichia coli (strain K12)", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 10, 1, 7, 9 ]

4

true

Family

4-hydroxy-tetrahydrodipicolinate synthase, DapA

DapA

4

IPR005264

5,264

N-acetylneuraminate lyase

NanA

Family

1,448

false

N-acetylneuraminate lyase (or N-Acetylneuraminic acid aldolase, NAL) catalyzes the cleavage of N-acetylneuraminic acid (sialic acid) to form pyruvate and N-acetyl-D-mannosamine. The enzyme plays an important role in the regulation of sialic acid metabolism in bacteria. It has a widespread application as biocatalyst for...

[ "GO:0008747", "GO:0005975" ]

[ "N-acetylneuraminate lyase activity", "carbohydrate metabolic process" ]

[ "molecular_function", "biological_process" ]

2

[ "HAMAP", "NCBIFAM", "CDD" ]

[ "MF_01237", "TIGR00683", "cd00954" ]

[ "N_acetylneuram_lyase", "nanA", "NAL" ]

[ 1234, 1125, 1409 ]

3

[ "EC", "METACYC", "REACTOME", "REACTOME", "REACTOME" ]

[ "4.1.3.3", "PWY-7581", "R-BTA-4085001", "R-HSA-4085001", "R-SSC-4085001" ]

[ "EC:4.1.3.3", "METACYC:PWY-7581", "REACTOME:R-BTA-4085001", "REACTOME:R-HSA-4085001", "REACTOME:R-SSC-4085001" ]

5

[ "1f5z", "1f6k", "1f6p", "1f73", "1f74", "1f7b", "1fdy", "1fdz", "1hl2", "1nal", "2wkj", "2wnn", "2wnq", "2wnz", "2wo5", "2wpb", "2xfw", "2ygy", "3lbc", "3lbm", "3lcf", "3lcg", "3lch", "3lci", "3lcl", "3lcw", "3lcx", "4ah7", "4aho", "4ahp", "4ahq", "4ama"...

55

[ "PUB00021758", "PUB00081235" ]

[ "12711733", "11432751" ]

[ "Mimicking natural evolution in vitro: an N-acetylneuraminate lyase mutant with an increased dihydrodipicolinate synthase activity.", "Characterization and mutagenesis of the recombinant N-acetylneuraminate lyase from Clostridium perfringens: insights into the reaction mechanism." ]

[ 2003, 2001 ]

2

[ "IPR002220" ]

[]

1

0

1

[ "Bacteria", "Eukaryota", "human gut metagenome" ]

[ 1308, 139, 1 ]

3

[ "Escherichia coli (strain K12)", "Homo sapiens" ]

[ 1, 1 ]

2

true

Family

N-acetylneuraminate lyase

NanA

9

IPR005265

5,265

Protoporphyrinogen oxidase HemJ-like

HemJ-like

Family

10,635

false

This entry includes HemJ ( ) from Synechocystis sp. (strain PCC 6803 / Kazusa). It is essential for protoporphyrinogen IX oxidase activity [ ] and is functionally coupled with coproporphyrinogen III oxidase [ ].

[]

0

[ "HAMAP", "PFAM", "PIRSF", "PANTHER", "NCBIFAM" ]

[ "MF_02239", "PF03653", "PIRSF004638", "PTHR40255", "TIGR00701" ]

[ "HemJ", "UPF0093", "UCP004638", "", "" ]

[ 9318, 10629, 9328, 10262, 4509 ]

5

[ "EC", "GP", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC" ]

[ "1.3.99.-", "GenProp1421", "PWY-6061", "PWY-6279", "PWY-6672", "PWY-6944", "PWY-6945", "PWY-6946", "PWY-6948", "PWY-7552", "PWY-7636", "PWY-8151", "PWY-8152", "PWY-8155" ]

[ "EC:1.3.99.-", "GP:GenProp1421", "METACYC:PWY-6061", "METACYC:PWY-6279", "METACYC:PWY-6672", "METACYC:PWY-6944", "METACYC:PWY-6945", "METACYC:PWY-6946", "METACYC:PWY-6948", "METACYC:PWY-7552", "METACYC:PWY-7636", "METACYC:PWY-8151", "METACYC:PWY-8152", "METACYC:PWY-8155" ]

14

[]

0

[ "PUB00090811", "PUB00090812" ]

[ "20823222", "29925590" ]

[ "Identification of a gene essential for protoporphyrinogen IX oxidase activity in the cyanobacterium Synechocystis sp. PCC6803.", "The cyanobacterial protoporphyrinogen oxidase HemJ is a new b-type heme protein functionally coupled with coproporphyrinogen III oxidase." ]

[ 2010, 2018 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 10476, 18, 141 ]

3

[]

0

true

Family

Protoporphyrinogen oxidase HemJ-like

HemJ-like

3

IPR005266

5,266

Uncharacterised protein family UPF0128

UPF0128

Family

54

false

The function of this family is unknown. These proteins are from 222 to 233 residues in length, lack hydrophobic stretches, and are found predominantly in thermophiles.

[]

0

[ "HAMAP", "PFAM", "PIRSF", "NCBIFAM" ]

[ "MF_00264", "PF03673", "PIRSF016179", "TIGR00703" ]

[ "UPF0128", "UPF0128", "UCP016179", "" ]

[ 43, 54, 31, 54 ]

4

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Methanobacteriota" ]

[ 18, 36 ]

2

[]

0

true

Family

Uncharacterised protein family UPF0128

UPF0128

2

IPR005267

5,267

Glycerol-3-phosphate transporter

G3P_transporter

Family

2,747

false

This family includes very hydrophobic proteins, predicted to span the membrane at least 8 times. The two members confirmed experimentally as glycerol-3-phosphate transporters, from Escherichia coli [ , , ] and Bacillus subtilis [ ], share more than 50 % amino acid identity.

[ "GO:0015169", "GO:0015794", "GO:0016020" ]

[ "glycerol-3-phosphate transmembrane transporter activity", "glycerol-3-phosphate transmembrane transport", "membrane" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "NCBIFAM" ]

[ "TIGR00712" ]

[ "glpT" ]

[ 2747 ]

1

[]

0

[ "1pw4" ]

1

[ "PUB00070830", "PUB00070831", "PUB00070833", "PUB00070834" ]

[ "19720022", "8012593", "16157640", "12813080" ]

[ "Structural basis of substrate selectivity in the glycerol-3-phosphate: phosphate antiporter GlpT.", "The glpT and glpQ genes of the glycerol regulon in Bacillus subtilis.", "Crystal structure and mechanism of GlpT, the glycerol-3-phosphate transporter from E. coli.", "Functional characterization of cysteine ...

[ 2009, 1994, 2005, 2003 ]

4

[ "IPR000849" ]

[]

1

0

1

[ "Bacteria", "Beauveria bassiana D1-5", "metagenomes" ]

[ 2742, 1, 4 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Glycerol-3-phosphate transporter

G3P_transporter

5

IPR005270

5,270

tRNA-dihydrouridine synthase, TIM-barrel, NifR3-related

tRNA_dU_NifR3-rel

Family

89

false

The function of this family is unknown, but it may include TIM-barrel proteins.

[]

0

[ "NCBIFAM" ]

[ "TIGR00736" ]

[ "nifR3_rel_arch" ]

[ 89 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Methanobacteriota", "bioreactor metagenome" ]

[ 88, 1 ]

2

[]

0

true

Family

tRNA-dihydrouridine synthase, TIM-barrel, NifR3-related

tRNA_dU_NifR3-rel

1

IPR005271

5,271

Carboxy-S-adenosyl-L-methionine synthase

CmoA

Family

4,761

false

This family represents the carboxy-S-adenosyl-L-methionine synthase CmoA. CmoA and CmoB are important components of the cmo5U biosynthetic pathway. These enzymes are involved in the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at the wobble position (34) of tRNA [ ]. Uridine-5-oxyacetic aci...

[ "GO:0002098" ]

[ "tRNA wobble uridine modification" ]

[ "biological_process" ]

1

[ "HAMAP", "PIRSF", "NCBIFAM" ]

[ "MF_01589", "PIRSF006325", "TIGR00740" ]

[ "Cx_SAM_synthase", "MeTrfase_bac", "" ]

[ 4671, 4702, 4698 ]

3

[ "EC", "GP", "GP", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC" ]

[ "2.1.3.-", "GenProp1077", "GenProp1340", "PWY-5", "PWY-7693", "PWY-7694", "PWY-8039", "PWY-8344" ]

[ "EC:2.1.3.-", "GP:GenProp1077", "GP:GenProp1340", "METACYC:PWY-5", "METACYC:PWY-7693", "METACYC:PWY-7694", "METACYC:PWY-8039", "METACYC:PWY-8344" ]

8

[ "1im8", "4gek", "4iwn" ]

3

[ "PUB00043575", "PUB00043576", "PUB00079207", "PUB00079211" ]

[ "15383682", "17942742", "25855808", "23676670" ]

[ "The modified wobble nucleoside uridine-5-oxyacetic acid in tRNAPro(cmo5UGG) promotes reading of all four proline codons in vivo.", "The wobble hypothesis revisited: uridine-5-oxyacetic acid is critical for reading of G-ending codons.", "Determinants of the CmoB carboxymethyl transferase utilized for selective ...

[ 2004, 2007, 2015, 2013 ]

4

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes", "unclassified Caudoviricetes" ]

[ 4694, 2, 63, 2 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Carboxy-S-adenosyl-L-methionine synthase

CmoA

9

IPR005272

5,272

Protein of unknown function DUF406

DUF406

Family

2,087

false

These small proteins are approximately 100 amino acids in length and appear to be found only in gamma proteobacteria. The function of this protein family is unknown [ ].

[]

0

[ "PFAM", "PANTHER", "NCBIFAM" ]

[ "PF04175", "PTHR38769", "TIGR00743" ]

[ "DUF406", "", "" ]

[ 2087, 2032, 1592 ]

3

[]

0

[ "2jz5", "2k3i", "2khd" ]

3

[ "PUB00055867" ]

[ "19927321" ]

[ "Solution NMR structures of proteins VPA0419 from Vibrio parahaemolyticus and yiiS from Shigella flexneri provide structural coverage for protein domain family PFAM 04175." ]

[ 2010 ]

1

[]

0

null

[ "Bacteria", "Opisthokonta", "metagenomes" ]

[ 2082, 2, 3 ]

3

[ "Escherichia coli (strain K12)" ]

[ 2 ]

1

true

Family

Protein of unknown function DUF406

DUF406

3

IPR005273

5,273

Uracil-DNA glycosylase family 4

Ura-DNA_glyco_family4

Domain

12,761

false

Uracil-DNA glycosylase (UDG) removes uracil from DNA to initiate DNA base excision repair. UDGs were classified into families 1, 2 and 3 on the basis of sequence similarity. Thermophilic UDGs have been identify more recently [ ] and they have been classified as a new UDG family, family 4 [ , ]. The enzymes of family 4 ...

[]

0

[ "NCBIFAM", "NCBIFAM" ]

[ "TIGR00758", "TIGR03914" ]

[ "UDG_fam4", "UDG_fam_dom" ]

[ 11507, 4526 ]

2

[ "EC", "GP" ]

[ "3.2.2.27", "GenProp0903" ]

[ "EC:3.2.2.27", "GP:GenProp0903" ]

2

[ "1l9g", "1ui0", "1ui1", "1vk2", "4zbx", "4zby", "4zbz", "6ail", "6ajo", "6ajp", "6ajq", "6ajr", "6ajs", "6io9", "6ioa", "6iob", "6ioc", "6iod", "6l5a", "6l5b", "6l6s", "8iie", "8iif", "8iig", "8iih", "8iii", "8iij", "8iil", "8iim", "8iin", "8iio", "8iip"...

36

[ "PUB00017590", "PUB00080615", "PUB00080616", "PUB00080617", "PUB00080618", "PUB00080619" ]

[ "14556741", "8837481", "11223884", "10946227", "12483510", "12000829" ]

[ "Crystal structure of a family 4 uracil-DNA glycosylase from Thermus thermophilus HB8.", "Uracil-DNA glycosylase activities in hyperthermophilic micro-organisms.", "Recent progress in the biology, chemistry and structural biology of DNA glycosylases.", "Structure and function in the uracil-DNA glycosylase sup...

[ 2003, 1996, 2001, 2000, 2002, 2002 ]

6

[ "IPR005122" ]

[]

1

0

1

[ "Archaea", "Bacteria", "Eukaryota", "Siphoviridae sp. ctCsv15", "unclassified sequences" ]

[ 766, 11619, 40, 1, 335 ]

5

[]

0

true

Domain

Uracil-DNA glycosylase family 4

Ura-DNA_glyco_family4

7

IPR005274

5,274

Inner membrane protein YhjD

IM_pro_YhjD

Family

2,174

false

This family, including YhjD in E. coli, is a conserved inner membrane protein. Its homologue, YihY, was incorrectly assigned to be ribonuclease BN previously [ ].

[]

0

[ "NCBIFAM" ]

[ "TIGR00766" ]

[ "" ]

[ 2174 ]

1

[]

0

[]

0

[ "PUB00020993" ]

[ "15764599" ]

[ "The RNase Z homologue encoded by Escherichia coli elaC gene is RNase BN." ]

[ 2005 ]

1

[ "IPR017039" ]

[]

1

0

1

[ "Bacteria", "Beauveria bassiana D1-5", "freshwater metagenome" ]

[ 2172, 1, 1 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Inner membrane protein YhjD

IM_pro_YhjD

9

IPR005275

5,275

L-fucose-proton symporter FucP

Lfuc_symporter_FucP

Family

5,365

false

This family describes the L-fucose-proton symporter (also known as L-fucose permease) in bacteria, which mediates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell [ ]. L-fucose(6-deoxy-L-galactose) is a monosaccharide found in glycoproteins and cell wall polysa...

[ "GO:0015150", "GO:0015535", "GO:0015756" ]

[ "fucose transmembrane transporter activity", "fucose:proton symporter activity", "fucose transmembrane transport" ]

[ "molecular_function", "molecular_function", "biological_process" ]

3

[ "NCBIFAM" ]

[ "TIGR00885" ]

[ "fucP" ]

[ 5365 ]

1

[ "GP" ]

[ "GenProp0458" ]

[ "GP:GenProp0458" ]

1

[ "3o7p", "3o7q" ]

2

[ "PUB00095607" ]

[ "8052131" ]

[ "Identification of a novel sugar-H+ symport protein, FucP, for transport of L-fucose into Escherichia coli." ]

[ 1994 ]

1

[ "IPR011701" ]

[]

1

0

1

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 5299, 35, 31 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

L-fucose-proton symporter FucP

Lfuc_symporter_FucP

8

IPR005277

5,277

Uncharacterised protein family, Major Facilitator Superfamily MSF4

Uncharacterised_MSF4

Family

12

false

Members of this family are archaeal putative MFS trasnporters. This rare family occurs in archaeal species such as Archaeoglobus fulgidus and Aeropyrum pernix. The MFS is a very old, large and diverse superfamily that includes several hundred sequenced members. They catalyse uniport, solute:cation (H+ or Na+) symport a...

[]

0

[ "NCBIFAM" ]

[ "TIGR00903" ]

[ "2A0129" ]

[ 12 ]

1

[]

0

[]

0

[]

0

[ "IPR049680" ]

[]

1

0

1

[ "Archaea" ]

[ 12 ]

1

[]

0

true

Family

Uncharacterised protein family, Major Facilitator Superfamily MSF4

Uncharacterised_MSF4

6

IPR005279

5,279

Dipeptide/tripeptide permease

Dipep/tripep_permease

Family

21,064

false

This entry includes dipeptide and tripeptide transporters belonging to the proton-dependent oligopeptide transporter (POT) family, also called the peptide transport (PTR) family. The transport of peptides into cells is a well-documented biological phenomenon which is accomplished by specific, energy-dependent transport...

[ "GO:1904680", "GO:0015833", "GO:0016020" ]

[ "peptide transmembrane transporter activity", "peptide transport", "membrane" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "NCBIFAM", "CDD" ]

[ "TIGR00924", "cd17346" ]

[ "yjdL_sub1_fam", "MFS_DtpA_like" ]

[ 20019, 19534 ]

2

[]

0

[ "2xut", "4aps", "4d2b", "4d2c", "4d2d", "4ikv", "4ikw", "4ikx", "4iky", "4ikz", "4lep", "4q65", "4tpg", "4tph", "4tpj", "4uvm", "4w6v", "4xni", "4xnj", "5d58", "5d59", "5d6k", "5mmt", "5oxk", "5oxl", "5oxm", "5oxn", "5oxo", "5oxp", "5oxq", "6ei3", "6eia"...

65

[ "PUB00003872", "PUB00094229" ]

[ "7476181", "26246134" ]

[ "The PTR family: a new group of peptide transporters.", "Role of electrostatic interactions for ligand recognition and specificity of peptide transporters." ]

[ 1995, 2015 ]

2

[ "IPR000109" ]

[ "IPR023517", "IPR023777", "IPR023778" ]

1

3

0

[ "Bacteria", "Eukaryota", "Methanobacterium", "metagenomes" ]

[ 20896, 52, 4, 112 ]

4

[ "Escherichia coli (strain K12)" ]

[ 4 ]

1

true

Family

Dipeptide/tripeptide permease

Dipep/tripep_permease

7

IPR005280

5,280

Homoserine kinase, type II

Homoserine_kinase_II

Family

5,693

false

This family is composed of unusual homoserine kinases, from a subset of bacteria, which have a protein kinase fold. These proteins do not bear any similarity to the GHMP family homoserine kinases (see ) present in most bacteria and eukaryotes. Homoserine kinase catalyzes the transfer of the gamma-phosphoryl group from ...

[ "GO:0004413", "GO:0009088" ]

[ "homoserine kinase activity", "L-threonine biosynthetic process" ]

[ "molecular_function", "biological_process" ]

2

[ "HAMAP", "NCBIFAM", "CDD" ]

[ "MF_00301", "TIGR00938", "cd05153" ]

[ "Homoser_kinase_2", "thrB_alt", "HomoserineK_II" ]

[ 5466, 4974, 5669 ]

3

[ "EC", "GP", "METACYC" ]

[ "2.7.1.39", "GenProp0159", "PWY-702" ]

[ "EC:2.7.1.39", "GP:GenProp0159", "METACYC:PWY-702" ]

3

[ "2ppq" ]

1

[ "PUB00081018" ]

[ "10589737" ]

[ "Organization of threonine biosynthesis genes from the obligate methylotroph Methylobacillus flagellatus." ]

[ 1999 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 5616, 10, 67 ]

3

[]

0

true

Family

Homoserine kinase, type II

Homoserine_kinase_II

6

IPR005281

5,281

Monovalent cation:proton antiporter, subunit B

CPA3_sub_B

Family

234

false

This family of proteins consists of bacterial multicomponent K+:H+ and Na+:H+ antiporters. The best characterised systems are the PhaABCDEFG system of Rhizobium meliloti which functions in pH adaptation and as a K+ efflux system and the MnhABCDEFG system of Staphylococcus aureus which functions as a Na+:H+ antiporter.T...

[ "GO:0008324", "GO:0006812", "GO:0016020" ]

[ "monoatomic cation transmembrane transporter activity", "monoatomic cation transport", "membrane" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "NCBIFAM" ]

[ "TIGR00943" ]

[ "2a6301s02" ]

[ 234 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria" ]

[ 234 ]

1

[]

0

true

Family

Monovalent cation:proton antiporter, subunit B

CPA3_sub_B

7

IPR005282

5,282

Lysosomal cystine transporter

LC_transporter

Family

5,190

false

Members of this family belong to the cystinosin family and are integral membrane lysosomal proteins and they are thought to transport cystines out of lysosomes. Protein ERS1 has been characterised and encodes a functional homologue of the human lysosomal cystine transporter [ ].

[]

0

[ "PANTHER", "NCBIFAM" ]

[ "PTHR13131", "TIGR00951" ]

[ "", "2A43" ]

[ 5185, 3231 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-425393", "R-BTA-5223345", "R-CEL-425393", "R-CEL-5223345", "R-DDI-425393", "R-DDI-5223345", "R-DME-425393", "R-DME-5223345", "R-HSA-425393", "R-HSA-5223345", "R-MMU-425393", "R-MMU-5223345", "R-SCE-425393", "R-SCE-5223345" ]

[ "REACTOME:R-BTA-425393", "REACTOME:R-BTA-5223345", "REACTOME:R-CEL-425393", "REACTOME:R-CEL-5223345", "REACTOME:R-DDI-425393", "REACTOME:R-DDI-5223345", "REACTOME:R-DME-425393", "REACTOME:R-DME-5223345", "REACTOME:R-HSA-425393", "REACTOME:R-HSA-5223345", "REACTOME:R-MMU-425393", "REACTOME:R-MM...

14

[ "7zk1", "7zkw", "7zkz", "8dke", "8dki", "8dkm", "8dkw", "8dkx", "8dyp" ]

9

[ "PUB00055018" ]

[ "15885099" ]

[ "ERS1 encodes a functional homologue of the human lysosomal cystine transporter." ]

[ 2005 ]

1

[]

0

null

[ "Eukaryota", "Marinifilum caeruleilacunae" ]

[ 5189, 1 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 4, 1, 1, 1, 11, 3, 1, 3, 4, 1, 5 ]

11

true

Family

Lysosomal cystine transporter

LC_transporter

8

IPR005283

5,283

Peroxysomal long chain fatty acyl transporter

FA_transporter

Family

1,301

false

Eukaryotic ABC transporters are found either as complete transporters or as half transporters, which dimerise to form an active transporter. Four half ABC transporter proteins have been identified in the human peroxisome membrane: the 70kDa peroxisomal membrane protein (PMP70), the adrenoleukodystrophy protein (ALDP), ...

[ "GO:0005324", "GO:0005524", "GO:0042626", "GO:0015910", "GO:0005777", "GO:0016020" ]

[ "long-chain fatty acid transmembrane transporter activity", "ATP binding", "ATPase-coupled transmembrane transporter activity", "long-chain fatty acid import into peroxisome", "peroxisome", "membrane" ]

[ "molecular_function", "molecular_function", "molecular_function", "biological_process", "cellular_component", "cellular_component" ]

6

[ "NCBIFAM" ]

[ "TIGR00954" ]

[ "3a01203" ]

[ 1301 ]

1

[ "EC", "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "...

[ "3.1.2.-", "7.6.2.-", "PWY-3602", "PWY-5109", "PWY-6322", "PWY-6585", "PWY-6917", "PWY-6948", "PWY-6995", "PWY-6997", "PWY-7007", "PWY-7216", "PWY-7292", "PWY-7401", "PWY-7402", "PWY-7471", "PWY-7690", "PWY-7706", "PWY-7733", "PWY-7734", "PWY-7738", "PWY-7740", "PWY-7741"...

[ "EC:3.1.2.-", "EC:7.6.2.-", "METACYC:PWY-3602", "METACYC:PWY-5109", "METACYC:PWY-6322", "METACYC:PWY-6585", "METACYC:PWY-6917", "METACYC:PWY-6948", "METACYC:PWY-6995", "METACYC:PWY-6997", "METACYC:PWY-7007", "METACYC:PWY-7216", "METACYC:PWY-7292", "METACYC:PWY-7401", "METACYC:PWY-7402", ...

61

[ "7rr9", "7rra", "7shm", "7shn", "7vr1", "7vwc", "7vx8", "7vzb", "7x07", "7x0t", "7x0z", "7x1w", "7xec", "7yrq", "8z0f", "8z9x" ]

16

[ "PUB00012622", "PUB00012623", "PUB00012624", "PUB00074967", "PUB00074968", "PUB00074969" ]

[ "1301993", "8441467", "8670886", "11248239", "18757502", "11883951" ]

[ "Mutations in the 70K peroxisomal membrane protein gene in Zellweger syndrome.", "Putative X-linked adrenoleukodystrophy gene shares unexpected homology with ABC transporters.", "The ABC transporter proteins Pat1 and Pat2 are required for import of long-chain fatty acids into peroxisomes of Saccharomyces cerevi...

[ 1992, 1993, 1996, 2001, 2008, 2002 ]

6

[]

0

null

[ "Opisthokonta" ]

[ 1301 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)" ]

[ 2, 3, 5, 6, 4, 2 ]

6

true

Family

Peroxysomal long chain fatty acyl transporter

FA_transporter

2