LiteFold/InterPro · Datasets at Hugging Face

IPR005406

5,406

Potassium channel subfamily K member 3

KCNK3

Family

726

false

TASK is a member of the TWIK-related (two P-domain) K + channel family identified in human tissues [ ]. It is widely distributed, being particularly abundant in the pancreas and placenta, but it is also found in the brain, heart, lung and kidney. Its amino acid identity to TWIK-1 and TREK-1 is rather low, being about 2...

[ "GO:0005252", "GO:0071805", "GO:0016020" ]

[ "open rectifier potassium channel activity", "potassium ion transmembrane transport", "membrane" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PRINTS" ]

[ "PR01584" ]

[ "TASK1CHANNEL" ]

[ 726 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-1299316", "R-HSA-5576886", "R-MMU-1299316", "R-MMU-5576886", "R-RNO-1299316", "R-RNO-5576886" ]

[ "REACTOME:R-HSA-1299316", "REACTOME:R-HSA-5576886", "REACTOME:R-MMU-1299316", "REACTOME:R-MMU-5576886", "REACTOME:R-RNO-1299316", "REACTOME:R-RNO-5576886" ]

6

[ "6rv2", "6rv3", "6rv4", "9g9x" ]

4

[ "PUB00001308", "PUB00007782" ]

[ "9312005", "11053038" ]

[ "TASK, a human background K+ channel to sense external pH variations near physiological pH.", "Molecular and functional properties of two-pore-domain potassium channels." ]

[ 1997, 2000 ]

2

[ "IPR003092" ]

[]

1

0

1

[ "Gnathostomata" ]

[ 726 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 2, 2, 6 ]

4

true

Family

Potassium channel subfamily K member 3

KCNK3

2

IPR005407

5,407

Potassium channel subfamily K member 9

KCNK9

Family

748

false

TASK is a member of the TWIK-related (two P-domain) K + channel family identified in human tissues [ ]. It is widely distributed, being particularly abundant in the pancreas and placenta, but it is also found in the brain, heart, lung and kidney. Its amino acid identity to TWIK-1 and TREK-1 is rather low, being about 2...

[ "GO:0005267", "GO:0071805", "GO:0016020" ]

[ "potassium channel activity", "potassium ion transmembrane transport", "membrane" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PRINTS" ]

[ "PR01585" ]

[ "TASK3CHANNEL" ]

[ 748 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-1299316", "R-HSA-5576886", "R-MMU-1299316", "R-MMU-5576886", "R-RNO-1299316", "R-RNO-5576886" ]

[ "REACTOME:R-HSA-1299316", "REACTOME:R-HSA-5576886", "REACTOME:R-MMU-1299316", "REACTOME:R-MMU-5576886", "REACTOME:R-RNO-1299316", "REACTOME:R-RNO-5576886" ]

6

[ "8k1j", "8k1q", "8k1v", "8k1z", "9g9v", "9g9w" ]

6

[ "PUB00001308", "PUB00067998", "PUB00067999" ]

[ "9312005", "11042359", "11431495" ]

[ "TASK, a human background K+ channel to sense external pH variations near physiological pH.", "Cloning, localisation and functional expression of a novel human, cerebellum specific, two pore domain potassium channel.", "KT3.2 and KT3.3, two novel human two-pore K(+) channels closely related to TASK-1." ]

[ 1997, 2000, 2001 ]

3

[ "IPR003092" ]

[]

1

0

1

[ "Vertebrata" ]

[ 748 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 3, 1, 2 ]

4

true

Family

Potassium channel subfamily K member 9

KCNK9

2

IPR005409

5,409

Two pore domain potassium channel, TWIK-2

2pore_dom_K_chnl_TWIK2

Family

385

false

Potassium channels are the most diverse group of the ion channel family [ , ]. They are important in shaping the action potential, and in neuronal excitability and plasticity [ ]. The potassium channel family is composed of several functionally distinct isoforms, which can be broadly separated into 2 groups [ ]: the pr...

[ "GO:0005267", "GO:0006813", "GO:0016020" ]

[ "potassium channel activity", "potassium ion transport", "membrane" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PRINTS" ]

[ "PR01587" ]

[ "TWIK2CHANNEL" ]

[ 385 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-1299308", "R-HSA-5576886", "R-MMU-1299308", "R-MMU-5576886", "R-RNO-1299308", "R-RNO-5576886" ]

[ "REACTOME:R-HSA-1299308", "REACTOME:R-HSA-5576886", "REACTOME:R-MMU-1299308", "REACTOME:R-MMU-5576886", "REACTOME:R-RNO-1299308", "REACTOME:R-RNO-5576886" ]

6

[ "9mek", "9mel" ]

2

[ "PUB00001055", "PUB00001278", "PUB00001298", "PUB00001308", "PUB00001622", "PUB00002771", "PUB00004011", "PUB00004020", "PUB00004219", "PUB00004878", "PUB00006577", "PUB00007784", "PUB00009378", "PUB00018829" ]

[ "1772658", "8605869", "9003761", "9312005", "1879548", "1373731", "2448635", "2451788", "7651518", "8917578", "2555158", "10075682", "11178249", "10887187" ]

[ "The molecular biology of K+ channels.", "TWIK-1, a ubiquitous human weakly inward rectifying K+ channel with a novel structure.", "Cloning, functional expression and brain localization of a novel unconventional outward rectifier K+ channel.", "TASK, a human background K+ channel to sense external pH variatio...

[ 1991, 1996, 1996, 1997, 1991, 1992, 1988, 1988, 1995, 1996, 1989, 1999, 2000, 2000 ]

14

[ "IPR005408" ]

[]

1

0

1

[ "Euteleostomi" ]

[ 385 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 3, 5, 2 ]

4

true

Family

Two pore domain potassium channel, TWIK-2

2pore_dom_K_chnl_TWIK2

4

IPR005410

5,410

Two pore domain potassium channel, THIK

2pore_dom_K_chnl_THIK

Family

2,087

false

Potassium channels are the most diverse group of the ion channel family [ , ]. They are important in shaping the action potential, and in neuronal excitability and plasticity [ ]. The potassium channel family is composed of several functionally distinct isoforms, which can be broadly separated into 2 groups [ ]: the pr...

[ "GO:0005267", "GO:0071805", "GO:0016020" ]

[ "potassium channel activity", "potassium ion transmembrane transport", "membrane" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PRINTS" ]

[ "PR01588" ]

[ "THIKCHANNEL" ]

[ 2087 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-1299287", "R-HSA-5576886", "R-MMU-1299287", "R-MMU-5576886", "R-RNO-1299287", "R-RNO-5576886" ]

[ "REACTOME:R-HSA-1299287", "REACTOME:R-HSA-5576886", "REACTOME:R-MMU-1299287", "REACTOME:R-MMU-5576886", "REACTOME:R-RNO-1299287", "REACTOME:R-RNO-5576886" ]

6

[ "9bsn", "9bws", "9byi", "9c07", "9c09", "9dwn", "9ft7", "9jgz", "9jh1" ]

9

[ "PUB00001055", "PUB00001622", "PUB00002771", "PUB00004011", "PUB00004020", "PUB00006577", "PUB00007785", "PUB00009378" ]

[ "1772658", "1879548", "1373731", "2448635", "2451788", "2555158", "11060316", "11178249" ]

[ "The molecular biology of K+ channels.", "Shaw-like rat brain potassium channel cDNA's with divergent 3' ends.", "Cloning, functional expression, and regulation of two K+ channels in human T lymphocytes.", "Multiple potassium-channel components are produced by alternative splicing at the Shaker locus in Droso...

[ 1991, 1991, 1992, 1988, 1988, 1989, 2001, 2000 ]

8

[ "IPR003280" ]

[]

1

0

1

[ "Bilateria" ]

[ 2087 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 3, 9, 2, 4, 6 ]

5

true

Family

Two pore domain potassium channel, THIK

2pore_dom_K_chnl_THIK

1

IPR005411

5,411

Claudin-2

Claudin2

Family

1,115

false

Claudins form the paracellular tight junction seal in epithelial tissues. In humans, 24 claudins (claudin 1-24) have been identified. Their ability to polymerise and form strands is affected by the cell types [ , , ]. They can also form heteropolymers with each other within and between tight junction strands [ ]. Most ...

[ "GO:0005198", "GO:0005923" ]

[ "structural molecule activity", "bicellular tight junction" ]

[ "molecular_function", "cellular_component" ]

2

[ "PRINTS" ]

[ "PR01589" ]

[ "CLAUDIN2" ]

[ 1115 ]

1

[ "REACTOME" ]

[ "R-HSA-420029" ]

[ "REACTOME:R-HSA-420029" ]

1

[]

0

[ "PUB00003085", "PUB00070979", "PUB00070980", "PUB00070981", "PUB00070982" ]

[ "9647647", "24665401", "20188437", "21372174", "10562289" ]

[ "Claudin-1 and -2: novel integral membrane proteins localizing at tight junctions with no sequence similarity to occludin.", "Claudin interactions in and out of the tight junction.", "The protoplasmic or exoplasmic face association of tight junction particles cannot predict paracellular permeability or heteroty...

[ 1998, 2013, 2010, 2011, 1999 ]

5

[ "IPR006187" ]

[]

1

0

1

[ "Gnathostomata" ]

[ 1115 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 1, 2, 4 ]

4

true

Family

Claudin-2

Claudin2

3

IPR005412

5,412

DNA-binding protein Fis

Fis_DNA-bd

Family

5,770

false

The Factor for Inversion Stimulation (FIS) protein is a regulator of bacterial functions, and binds specifically to weakly related DNA sequences [ ]. It activates ribosomal RNA transcription, and is involved in upstream activation of rRNA promoters. Found in gammaproteobacterial microbes, the protein has been shown to ...

[ "GO:0003677", "GO:0006355" ]

[ "DNA binding", "regulation of DNA-templated transcription" ]

[ "molecular_function", "biological_process" ]

2

[ "HAMAP", "PIRSF", "PRINTS", "PANTHER" ]

[ "MF_00166", "PIRSF002097", "PR01591", "PTHR47918" ]

[ "DNA_binding_Fis", "DNA-binding_Fis", "DNABINDNGFIS", "" ]

[ 1573, 5230, 4038, 5766 ]

4

[]

0

[ "1etk", "1eto", "1etq", "1etv", "1etw", "1etx", "1ety", "1f36", "1fia", "1fip", "3fis", "3iv5", "3jr9", "3jra", "3jrb", "3jrc", "3jrd", "3jre", "3jrf", "3jrg", "3jrh", "3jri", "4fis", "4ihv", "4ihw", "4ihx", "4ihy", "5ds9", "5dtd", "5e3l", "5e3m", "5e3n"...

37

[ "PUB00007180", "PUB00007181", "PUB00007182", "PUB00007183", "PUB00007184", "PUB00007786" ]

[ "7536730", "11123690", "11532124", "9738943", "11183780", "1946369" ]

[ "Sequence, regulation, and functions of fis in Salmonella typhimurium.", "Fis, a DNA nucleoid-associated protein, is involved in Salmonella typhimurium SPI-1 invasion gene expression.", "Role of the nucleoid-associated protein Fis in the regulation of virulence properties of enteropathogenic Escherichia coli.",...

[ 1995, 2001, 2001, 1998, 2000, 1991 ]

6

[]

0

null

[ "Bacteria", "Opisthokonta", "unclassified sequences" ]

[ 5675, 5, 90 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

DNA-binding protein Fis

Fis_DNA-bd

8

IPR005413

5,413

Low calcium response V antigen

LowCa_resp_V_Ag

Family

207

false

The type III secretion system of Gram-negative bacteria is used to transport virulence factors from the pathogen directly into the host cell [ ] and is only triggered when the bacterium comes into close contact with the host. Effector proteins secreted by the type III system do not possess a secretion signal, and are c...

[ "GO:0005576" ]

[ "extracellular region" ]

[ "cellular_component" ]

1

[ "PFAM", "PRINTS" ]

[ "PF04792", "PR01592" ]

[ "LcrV", "LCRVANTIGEN" ]

[ 207, 179 ]

2

[]

0

[ "1r6f", "4jbu", "6cyf", "8cr9", "8crb", "9fm0", "9jbq" ]

7

[ "PUB00003585", "PUB00007787", "PUB00007788", "PUB00007789", "PUB00007790", "PUB00007791" ]

[ "9618447", "9440524", "9495760", "11443094", "11489861", "11500471" ]

[ "Type III protein secretion systems in bacterial pathogens of animals and plants.", "YopD of Yersinia pestis plays a role in negative regulation of the low-calcium response in addition to its role in translocation of Yops.", "The Yersinia Yop virulon: LcrV is required for extrusion of the translocators YopB and...

[ 1998, 1998, 1998, 2001, 2001, 2001 ]

6

[]

0

null

[ "Bacteria", "Ecdysozoa" ]

[ 205, 2 ]

2

[]

0

true

Family

Low calcium response V antigen

LowCa_resp_V_Ag

6

IPR005414

5,414

Guanine nucleotide exchange factor SopE

SopE

Family

1,009

false

The type III secretion system of Gram-negative bacteria is used to transport virulence factors from the pathogen directly into the host cell [ ] and is only triggered when the bacterium comes into close contact with the host. Effector proteins secreted by the type III system do not possess a secretion signal, and are c...

[ "GO:0005085", "GO:0030036", "GO:0090630", "GO:0005576" ]

[ "guanyl-nucleotide exchange factor activity", "actin cytoskeleton organization", "activation of GTPase activity", "extracellular region" ]

[ "molecular_function", "biological_process", "biological_process", "cellular_component" ]

4

[ "PIRSF", "PRINTS" ]

[ "PIRSF034781", "PR01593" ]

[ "SecIII_sopE", "SOPEPROTEIN" ]

[ 772, 1009 ]

2

[]

0

[ "1gzs", "1r6e", "1r9k", "2jok", "2jol" ]

5

[ "PUB00003585", "PUB00007792", "PUB00007793" ]

[ "9618447", "9482928", "11316807" ]

[ "Type III protein secretion systems in bacterial pathogens of animals and plants.", "A substrate of the centisome 63 type III protein secretion system of Salmonella typhimurium is encoded by a cryptic bacteriophage.", "SopE acts as an Rab5-specific nucleotide exchange factor and recruits non-prenylated Rab5 on ...

[ 1998, 1998, 2001 ]

3

[]

0

null

[ "Pseudomonadota" ]

[ 1009 ]

1

[]

0

true

Family

Guanine nucleotide exchange factor SopE

SopE

3

IPR005415

5,415

Type III secretion system, low calcium response, chaperone LcrH/SycD

T3SS_Ca_resp_chp_LcrH/SycD

Family

2,344

false

The type III secretion system of Gram-negative bacteria is used to transport virulence factors from the pathogen directly into the host cell [ ] and is only triggered when the bacterium comes into close contact with the host. Effector proteins secreted by the type III system do not possess a secretion signal, and are c...

[]

0

[ "PRINTS", "NCBIFAM" ]

[ "PR01595", "TIGR02552" ]

[ "SYCDCHAPRONE", "LcrH_SycD" ]

[ 1539, 2084 ]

2

[ "GP" ]

[ "GenProp0052" ]

[ "GP:GenProp0052" ]

1

[ "2vgx", "2vgy", "2xcb", "2xcc", "3gyz", "3gz1", "3gz2", "3ks2", "3wxx", "4am9", "4jl0", "4nrh", "6scb", "7axy", "7ayw", "7azv", "7b1u", "7nhw", "7nl8", "7nrg", "7o04", "7o6s", "7owv", "7p42", "7pe0", "7pef", "8qh6" ]

27

[ "PUB00003585", "PUB00007787", "PUB00007794", "PUB00007795", "PUB00007796", "PUB00015206", "PUB00018830", "PUB00018832", "PUB00020767", "PUB00020778" ]

[ "9618447", "9440524", "7937981", "10476031", "11123678", "12799000", "1705541", "9987117", "11844757", "14673772" ]

[ "Type III protein secretion systems in bacterial pathogens of animals and plants.", "YopD of Yersinia pestis plays a role in negative regulation of the low-calcium response in addition to its role in translocation of Yops.", "Individual chaperones required for Yop secretion by Yersinia.", "Insertion of a Yop ...

[ 1998, 1998, 1994, 1999, 2000, 2003, 1991, 1999, 2002, 2003 ]

10

[]

[ "IPR016379" ]

0

1

0

[ "Bacteria", "Ecdysozoa", "metagenomes" ]

[ 2337, 3, 4 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Type III secretion system, low calcium response, chaperone LcrH/SycD

T3SS_Ca_resp_chp_LcrH/SycD

5

IPR005416

5,416

Type III secretion chaperone SycE

T3SS_chp_SycE

Family

111

false

The type III secretion system of Gram-negative bacteria is used to transport virulence factors from the pathogen directly into the host cell [ ] and is only triggered when the bacterium comes into close contact with the host. Effector proteins secreted by the type III system do not possess a secretion signal, and are c...

[ "GO:0030254" ]

[ "protein secretion by the type III secretion system" ]

[ "biological_process" ]

1

[ "PIRSF", "PRINTS" ]

[ "PIRSF011271", "PR01596" ]

[ "T3SS_chp_SycE_GmN_bac", "SYCECHAPRONE" ]

[ 37, 111 ]

2

[]

0

[ "1jya", "1k6z", "1l2w", "1n5b", "4jmf", "6jnp", "7eva" ]

7

[ "PUB00003585", "PUB00006632", "PUB00006679", "PUB00007794", "PUB00007797", "PUB00007798" ]

[ "9618447", "2191183", "10419539", "7937981", "7806344", "11372029" ]

[ "Type III protein secretion systems in bacterial pathogens of animals and plants.", "The cytotoxic protein YopE of Yersinia obstructs the primary host defence.", "Yersinia enterocolitica type III secretion. On the role of SycE in targeting YopE into HeLa cells.", "Individual chaperones required for Yop secret...

[ 1998, 1990, 1999, 1994, 1995, 2001 ]

6

[ "IPR010261" ]

[]

1

0

1

[ "Pseudomonadota" ]

[ 111 ]

1

[]

0

true

Family

Type III secretion chaperone SycE

T3SS_chp_SycE

9

IPR005417

5,417

Tight junction protein ZO

ZO

Family

6,276

false

The zona occuldens proteins (ZO-1, ZO-2 and ZO-3) are a family of TJ-associated proteins that function as cross-linkers, anchoring the TJ strand proteins to the actin-based cytoskeleton [ ]. Each protein contains three PDZ (postsynaptic density, disc-large, ZO-1) domains, a single SH3 (Src Homology-3) domain and a GK (...

[ "GO:0005923" ]

[ "bicellular tight junction" ]

[ "cellular_component" ]

1

[ "PRINTS" ]

[ "PR01597" ]

[ "ZONOCCLUDNS" ]

[ 6276 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-191650", "R-HSA-2028269", "R-HSA-351906", "R-HSA-8935964", "R-HSA-8980692", "R-HSA-9013026", "R-HSA-9013106", "R-HSA-9705677", "R-MMU-191650", "R-MMU-2028269", "R-MMU-351906", "R-MMU-8980692", "R-MMU-9013026", "R-MMU-9013106", "R-RNO-191650", "R-RNO-2028269", "R-RNO-351906" ]

[ "REACTOME:R-HSA-191650", "REACTOME:R-HSA-2028269", "REACTOME:R-HSA-351906", "REACTOME:R-HSA-8935964", "REACTOME:R-HSA-8980692", "REACTOME:R-HSA-9013026", "REACTOME:R-HSA-9013106", "REACTOME:R-HSA-9705677", "REACTOME:R-MMU-191650", "REACTOME:R-MMU-2028269", "REACTOME:R-MMU-351906", "REACTOME:R-...

17

[ "3shw" ]

1

[ "PUB00007799", "PUB00007800", "PUB00007801" ]

[ "9214391", "10601346", "9792688" ]

[ "Involvement of ZO-1 in cadherin-based cell adhesion through its direct binding to alpha catenin and actin filaments.", "Direct binding of three tight junction-associated MAGUKs, ZO-1, ZO-2, and ZO-3, with the COOH termini of claudins.", "The tight junction protein ZO-1 establishes a link between the transmembr...

[ 1997, 1999, 1998 ]

3

[]

[ "IPR005418", "IPR005419", "IPR005420" ]

0

3

0

[ "Vertebrata" ]

[ 6276 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 112, 24, 9, 23 ]

4

true

Family

Tight junction protein ZO

ZO

5

IPR005418

5,418

Tight junction protein ZO-1

ZO-1

Family

2,262

false

The zona occuldens proteins (ZO-1, ZO-2 and ZO-3) are a family of tight junction associated proteins that function as cross-linkers, anchoring the TJ strand proteins to the actin-based cytoskeleton [ ]. Each protein contains three PDZ (postsynaptic density, disc-large, ZO-1) domains, a single SH3 (Src Homology-3) domai...

[ "GO:0005923" ]

[ "bicellular tight junction" ]

[ "cellular_component" ]

1

[ "PRINTS" ]

[ "PR01598" ]

[ "ZONOCCLUDNS1" ]

[ 2262 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-191650", "R-HSA-2028269", "R-HSA-351906", "R-HSA-8935964", "R-HSA-9705677", "R-MMU-191650", "R-MMU-2028269", "R-MMU-351906", "R-RNO-191650", "R-RNO-2028269", "R-RNO-351906" ]

[ "REACTOME:R-HSA-191650", "REACTOME:R-HSA-2028269", "REACTOME:R-HSA-351906", "REACTOME:R-HSA-8935964", "REACTOME:R-HSA-9705677", "REACTOME:R-MMU-191650", "REACTOME:R-MMU-2028269", "REACTOME:R-MMU-351906", "REACTOME:R-RNO-191650", "REACTOME:R-RNO-2028269", "REACTOME:R-RNO-351906" ]

11

[]

0

[ "PUB00007799", "PUB00007800", "PUB00007801", "PUB00007802", "PUB00007803", "PUB00057053", "PUB00085529" ]

[ "9214391", "10601346", "9792688", "3528172", "9531559", "22030391", "21965684" ]

[ "Involvement of ZO-1 in cadherin-based cell adhesion through its direct binding to alpha catenin and actin filaments.", "Direct binding of three tight junction-associated MAGUKs, ZO-1, ZO-2, and ZO-3, with the COOH termini of claudins.", "The tight junction protein ZO-1 establishes a link between the transmembr...

[ 1997, 1999, 1998, 1986, 1998, 2011, 2011 ]

7

[ "IPR005417" ]

[]

1

0

1

[ "Gnathostomata" ]

[ 2262 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 14, 10, 3, 6 ]

4

true

Family

Tight junction protein ZO-1

ZO-1

1

IPR005419

5,419

Tight junction protein ZO-2

ZO-2

Family

2,030

false

The zona occuldens proteins (ZO-1, ZO-2 and ZO-3) are a family of tight junction associated proteins that function as cross-linkers, anchoring the TJ strand proteins to the actin-based cytoskeleton [ ]. Each protein contains three PDZ (postsynaptic density, disc-large, ZO-1) domains, a single SH3 (Src Homology-3) domai...

[ "GO:0005923" ]

[ "bicellular tight junction" ]

[ "cellular_component" ]

1

[ "PRINTS" ]

[ "PR01599" ]

[ "ZONOCCLUDNS2" ]

[ 2030 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-2028269", "R-HSA-351906", "R-HSA-8980692", "R-HSA-9013026", "R-HSA-9013106", "R-MMU-2028269", "R-MMU-351906", "R-MMU-8980692", "R-MMU-9013026", "R-MMU-9013106" ]

[ "REACTOME:R-HSA-2028269", "REACTOME:R-HSA-351906", "REACTOME:R-HSA-8980692", "REACTOME:R-HSA-9013026", "REACTOME:R-HSA-9013106", "REACTOME:R-MMU-2028269", "REACTOME:R-MMU-351906", "REACTOME:R-MMU-8980692", "REACTOME:R-MMU-9013026", "REACTOME:R-MMU-9013106" ]

10

[]

0

[ "PUB00007799", "PUB00007800", "PUB00007801", "PUB00007804" ]

[ "9214391", "10601346", "9792688", "2014265" ]

[ "Involvement of ZO-1 in cadherin-based cell adhesion through its direct binding to alpha catenin and actin filaments.", "Direct binding of three tight junction-associated MAGUKs, ZO-1, ZO-2, and ZO-3, with the COOH termini of claudins.", "The tight junction protein ZO-1 establishes a link between the transmembr...

[ 1997, 1999, 1998, 1991 ]

4

[ "IPR005417" ]

[]

1

0

1

[ "Gnathostomata" ]

[ 2030 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 12, 15, 4, 14 ]

4

true

Family

Tight junction protein ZO-2

ZO-2

2

IPR005420

5,420

Tight junction protein ZO-3

ZO-3

Family

836

false

The zona occuldens proteins (ZO-1, ZO-2 and ZO-3) are a family of tight junction associated proteins that function as cross-linkers, anchoring the TJ strand proteins to the actin-based cytoskeleton [ ]. Each protein contains three PDZ (postsynaptic density, disc-large, ZO-1) domains, a single SH3 (Src Homology-3) domai...

[ "GO:0005923" ]

[ "bicellular tight junction" ]

[ "cellular_component" ]

1

[ "PRINTS" ]

[ "PR01600" ]

[ "ZONOCCLUDNS3" ]

[ 836 ]

1

[]

0

[ "3kfv" ]

1

[ "PUB00007799", "PUB00007800", "PUB00007801", "PUB00007803", "PUB00007805" ]

[ "9214391", "10601346", "9792688", "9531559", "8408213" ]

[ "Involvement of ZO-1 in cadherin-based cell adhesion through its direct binding to alpha catenin and actin filaments.", "Direct binding of three tight junction-associated MAGUKs, ZO-1, ZO-2, and ZO-3, with the COOH termini of claudins.", "The tight junction protein ZO-1 establishes a link between the transmembr...

[ 1997, 1999, 1998, 1998, 1993 ]

5

[ "IPR005417" ]

[]

1

0

1

[ "Gnathostomata", "uncultured Solirubrobacteraceae bacterium" ]

[ 835, 1 ]

2

[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 3, 3, 3 ]

3

true

Family

Tight junction protein ZO-3

ZO-3

7

IPR005421

5,421

Voltage-dependent calcium channel, gamma-1 subunit

VDCC_g1su

Family

811

false

Ca2+ ions are unique in that they not only carry charge but they are also the most widely used of diffusible second messengers. Voltage-dependent Ca2+ channels (VDCC) are a family of molecules that allow cells to couple electrical activity to intracellular Ca2+ signalling. The opening and closing of these channels by d...

[ "GO:0005245", "GO:0070588", "GO:0005891" ]

[ "voltage-gated calcium channel activity", "calcium ion transmembrane transport", "voltage-gated calcium channel complex" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PRINTS" ]

[ "PR01601" ]

[ "VDCCGAMMA1" ]

[ 811 ]

1

[]

0

[ "3jbr", "5gjv", "5gjw", "6jp5", "6jp8", "6jpa", "6jpb", "7jpk", "7jpl", "7jpv", "7jpw", "7jpx", "8e56", "8e57", "8e58" ]

15

[ "PUB00007806", "PUB00007807", "PUB00007808", "PUB00007809", "PUB00036034" ]

[ "11170751", "2158672", "1718988", "1716787", "14657414" ]

[ "A cluster of three novel Ca2+ channel gamma subunit genes on chromosome 19q13.4: evolution and expression profile of the gamma subunit gene family.", "Primary structure of the gamma subunit of the DHP-sensitive calcium channel from skeletal muscle.", "Heterologous regulation of the cardiac Ca2+ channel alpha 1...

[ 2001, 1990, 1991, 1991, 2003 ]

5

[ "IPR008368" ]

[]

1

0

1

[ "Vertebrata" ]

[ 811 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 4, 1, 3, 3 ]

4

true

Family

Voltage-dependent calcium channel, gamma-1 subunit

VDCC_g1su

4

IPR005422

5,422

Voltage-dependent calcium channel, gamma-2 subunit

VDCC_g2su

Family

876

false

Ca2+ ions are unique in that they not only carry charge but they are also the most widely used of diffusible second messengers. Voltage-dependent Ca2+ channels (VDCC) are a family of molecules that allow cells to couple electrical activity to intracellular Ca2+ signalling. The opening and closing of these channels by d...

[ "GO:0005245", "GO:0070588", "GO:0005891" ]

[ "voltage-gated calcium channel activity", "calcium ion transmembrane transport", "voltage-gated calcium channel complex" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PRINTS" ]

[ "PR01602" ]

[ "VDCCGAMMA2" ]

[ 876 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-112308", "R-HSA-399719", "R-HSA-5682910", "R-MMU-112308", "R-MMU-399719", "R-MMU-5682910", "R-RNO-112308", "R-RNO-399719", "R-RNO-5682910" ]

[ "REACTOME:R-HSA-112308", "REACTOME:R-HSA-399719", "REACTOME:R-HSA-5682910", "REACTOME:R-MMU-112308", "REACTOME:R-MMU-399719", "REACTOME:R-MMU-5682910", "REACTOME:R-RNO-112308", "REACTOME:R-RNO-399719", "REACTOME:R-RNO-5682910" ]

9

[ "5kk2", "5vot", "5vou", "5vov", "6njl", "6njm", "6njn", "8c1r", "8c1s", "8fp4", "8fp9", "8fpg", "8fps", "8fq1", "8fq5", "8fqb", "8fqf", "8p3q", "8p3s", "8p3x", "8p3y", "8p3z", "8piv", "9b5z", "9b60", "9b61", "9b63", "9b64", "9b67", "9b6a", "9hpc", "9hpd"...

43

[ "PUB00007806", "PUB00007810", "PUB00018838", "PUB00036034" ]

[ "11170751", "9697694", "11140673", "14657414" ]

[ "A cluster of three novel Ca2+ channel gamma subunit genes on chromosome 19q13.4: evolution and expression profile of the gamma subunit gene family.", "The mouse stargazer gene encodes a neuronal Ca2+-channel gamma subunit.", "Stargazin regulates synaptic targeting of AMPA receptors by two distinct mechanisms."...

[ 2001, 1998, 2000, 2003 ]

4

[ "IPR008368" ]

[]

1

0

1

[ "Gnathostomata" ]

[ 876 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 1, 2, 2 ]

4

true

Family

Voltage-dependent calcium channel, gamma-2 subunit

VDCC_g2su

6

IPR005423

5,423

Voltage-dependent calcium channel, gamma-4 subunit

VDCC_g4su

Family

930

false

Ca2+ ions are unique in that they not only carry charge but they are also the most widely used of diffusible second messengers. Voltage-dependent Ca2+ channels (VDCC) are a family of molecules that allow cells to couple electrical activity to intracellular Ca2+ signalling. The opening and closing of these channels by d...

[ "GO:0005245", "GO:0070588", "GO:0005891" ]

[ "voltage-gated calcium channel activity", "calcium ion transmembrane transport", "voltage-gated calcium channel complex" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PRINTS" ]

[ "PR01603" ]

[ "VDCCGAMMA4" ]

[ 930 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-112308", "R-HSA-399719", "R-HSA-5576892", "R-HSA-5576893", "R-HSA-5682910", "R-MMU-112308", "R-MMU-399719", "R-MMU-5576892", "R-MMU-5576893", "R-MMU-5682910", "R-RNO-112308", "R-RNO-399719", "R-RNO-5576892", "R-RNO-5576893", "R-RNO-5682910" ]

[ "REACTOME:R-HSA-112308", "REACTOME:R-HSA-399719", "REACTOME:R-HSA-5576892", "REACTOME:R-HSA-5576893", "REACTOME:R-HSA-5682910", "REACTOME:R-MMU-112308", "REACTOME:R-MMU-399719", "REACTOME:R-MMU-5576892", "REACTOME:R-MMU-5576893", "REACTOME:R-MMU-5682910", "REACTOME:R-RNO-112308", "REACTOME:R-R...

15

[]

0

[ "PUB00007806", "PUB00007811", "PUB00007812", "PUB00036034" ]

[ "11170751", "10734232", "11313431", "14657414" ]

[ "A cluster of three novel Ca2+ channel gamma subunit genes on chromosome 19q13.4: evolution and expression profile of the gamma subunit gene family.", "A family of gamma-like calcium channel subunits.", "Functional roles of gamma2, gamma3 and gamma4, three new Ca2+ channel subunits, in P/Q-type Ca2+ channel exp...

[ 2001, 2000, 2001, 2003 ]

4

[ "IPR008368" ]

[]

1

0

1

[ "Gnathostomata" ]

[ 930 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 1, 3, 2 ]

4

true

Family

Voltage-dependent calcium channel, gamma-4 subunit

VDCC_g4su

4

IPR005424

5,424

Potassium voltage-gated channel subfamily E member 1

KCNE1

Family

539

false

KCNE1 (Potassium voltage-gated channel subfamily E member 1, also known as Mink) subunits associate with KCNQ1 alpha subunits to form channels that are responsible for the IkS currents that determine the duration of the action potential in cardiac muscle [ ]. Mutations in both of the genes encoding these subunits cause...

[ "GO:0005249", "GO:0006813", "GO:0016020" ]

[ "voltage-gated potassium channel activity", "potassium ion transport", "membrane" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PRINTS" ]

[ "PR01604" ]

[ "KCNE1CHANNEL" ]

[ 539 ]

1

[ "REACTOME", "REACTOME" ]

[ "R-HSA-5576890", "R-HSA-5576893" ]

[ "REACTOME:R-HSA-5576890", "REACTOME:R-HSA-5576893" ]

2

[ "2k21", "9u7f", "9vec", "9vei" ]

4

[ "PUB00001055", "PUB00001622", "PUB00002771", "PUB00004011", "PUB00004020", "PUB00006577", "PUB00007813", "PUB00009378", "PUB00099633" ]

[ "1772658", "1879548", "1373731", "2448635", "2451788", "2555158", "10493825", "11178249", "19219384" ]

[ "The molecular biology of K+ channels.", "Shaw-like rat brain potassium channel cDNA's with divergent 3' ends.", "Cloning, functional expression, and regulation of two K+ channels in human T lymphocytes.", "Multiple potassium-channel components are produced by alternative splicing at the Shaker locus in Droso...

[ 1991, 1991, 1992, 1988, 1988, 1989, 1999, 2000, 2009 ]

9

[ "IPR000369" ]

[]

1

0

1

[ "Amniota" ]

[ 539 ]

1

[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 7, 2, 2 ]

3

true

Family

Potassium voltage-gated channel subfamily E member 1

KCNE1

9

IPR005426

5,426

Potassium channel, voltage-dependent, beta subunit, KCNE3

K_chnl_volt-dep_bsu_KCNE3

Family

408

false

Potassium channels are the most diverse group of the ion channel family [ , ]. They are important in shaping the action potential, and in neuronal excitability and plasticity [ ]. The potassium channel family is composed of several functionally distinct isoforms, which can be broadly separated into 2 groups [ ]: the pr...

[ "GO:0005249", "GO:0006813", "GO:0016020" ]

[ "voltage-gated potassium channel activity", "potassium ion transport", "membrane" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PRINTS" ]

[ "PR01606" ]

[ "KCNE3CHANNEL" ]

[ 408 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-5576890", "R-HSA-5576893", "R-MMU-5576890", "R-MMU-5576893", "R-RNO-5576890", "R-RNO-5576893" ]

[ "REACTOME:R-HSA-5576890", "REACTOME:R-HSA-5576893", "REACTOME:R-MMU-5576890", "REACTOME:R-MMU-5576893", "REACTOME:R-RNO-5576890", "REACTOME:R-RNO-5576893" ]

6

[ "2ndj", "6v00", "6v01", "9wd8" ]

4

[ "PUB00001055", "PUB00001622", "PUB00002771", "PUB00004011", "PUB00004020", "PUB00006577", "PUB00007815", "PUB00007816", "PUB00009378" ]

[ "1772658", "1879548", "1373731", "2448635", "2451788", "2555158", "11207363", "10646604", "11178249" ]

[ "The molecular biology of K+ channels.", "Shaw-like rat brain potassium channel cDNA's with divergent 3' ends.", "Cloning, functional expression, and regulation of two K+ channels in human T lymphocytes.", "Multiple potassium-channel components are produced by alternative splicing at the Shaker locus in Droso...

[ 1991, 1991, 1992, 1988, 1988, 1989, 2001, 2000, 2000 ]

9

[ "IPR000369" ]

[]

1

0

1

[ "Amniota" ]

[ 408 ]

1

[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 5, 2, 2 ]

3

true

Family

Potassium channel, voltage-dependent, beta subunit, KCNE3

K_chnl_volt-dep_bsu_KCNE3

5

IPR005427

5,427

Effector protein BipC/T3SS SctB

BipC/SctB

Family

682

false

Some Gram-negative animal enteropathogens express a specialised secretion system to directly "inject" exotoxins into the cytoplasm of host cells. The system is composed of structural proteins and exotoxin effectors; these are often encoded on large virulence plasmids or on the bacterial chromosome itself [ ]. Members m...

[]

0

[ "PFAM", "NCBIFAM" ]

[ "PF09599", "TIGR02101" ]

[ "IpaC_SipC", "IpaC_SipC" ]

[ 682, 513 ]

2

[ "GP" ]

[ "GenProp0052" ]

[ "GP:GenProp0052" ]

1

[]

0

[ "PUB00007582", "PUB00007817", "PUB00007818", "PUB00007819", "PUB00151514", "PUB00151516" ]

[ "7608068", "11018143", "3057506", "9784535", "17367391", "23544147" ]

[ "Homologs of the Shigella IpaB and IpaC invasins are required for Salmonella typhimurium entry into cultured epithelial cells.", "Assembly and function of type III secretory systems.", "Characterization of invasion plasmid antigen genes (ipaBCD) from Shigella flexneri.", "Inhibition of Salmonella typhimurium ...

[ 1995, 2000, 1988, 1998, 2007, 2013 ]

6

[]

0

null

[ "Pseudomonadota" ]

[ 682 ]

1

[]

0

true

Family

Effector protein BipC/T3SS SctB

BipC/SctB

7

IPR005429

5,429

Lysosome membrane protein II

LimpII

Family

2,264

false

Lysosome membrane protein II (LIMP II) is a 478-residue glycoprotein expressed in the membrane of lysosomes and secretory granules with lysosomal properties [ ]. The N-terminal segment (residues ~4-26) constitutes an uncleavable signal peptide [ ]. LIMP II possesses an additional C-terminal hydrophobic region that, tog...

[ "GO:0005044", "GO:0005764" ]

[ "scavenger receptor activity", "lysosome" ]

[ "molecular_function", "cellular_component" ]

2

[ "PRINTS" ]

[ "PR01611" ]

[ "LIMPII" ]

[ 2264 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-8856825", "R-HSA-8856828", "R-MMU-8856825", "R-MMU-8856828", "R-RNO-8856825", "R-RNO-8856828" ]

[ "REACTOME:R-HSA-8856825", "REACTOME:R-HSA-8856828", "REACTOME:R-MMU-8856825", "REACTOME:R-MMU-8856828", "REACTOME:R-RNO-8856825", "REACTOME:R-RNO-8856828" ]

6

[ "4f7b", "4q4b", "4q4f", "4tvz", "4tw0", "4tw2", "5uph", "5xbm", "6i2k", "9fjf" ]

10

[ "PUB00010597" ]

[ "1715871" ]

[ "Cloning, sequencing, and expression of a cDNA encoding rat LIMP II, a novel 74-kDa lysosomal membrane protein related to the surface adhesion protein CD36." ]

[ 1991 ]

1

[ "IPR002159" ]

[]

1

0

1

[ "Eukaryota" ]

[ 2264 ]

1

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 3, 1, 13, 2, 4 ]

5

true

Family

Lysosome membrane protein II

LimpII

4

IPR005430

5,430

P pili tip fibrillum PapF protein

P_pili_tip_PapF

Family

302

false

The Gram-negative pathogen Escherichia coli causes several common bacterial illnesses in humans, including diarrhoea, neonatal meningitidis and urinary tract infections. Attachment to host tissues is essential for successful invasion, and requires interaction between a bacterial adhesive protein and its target receptor...

[ "GO:0009289" ]

[ "pilus" ]

[ "cellular_component" ]

1

[ "PRINTS" ]

[ "PR01613" ]

[ "FIMBRIALPAPF" ]

[ 302 ]

1

[]

0

[ "2w07", "7lhi" ]

2

[ "PUB00007359", "PUB00007360", "PUB00007820" ]

[ "1348107", "7816100", "8096174" ]

[ "P pili in uropathogenic E. coli are composite fibres with distinct fibrillar adhesive tips.", "Structural polymorphism of bacterial adhesion pili.", "Initiation of assembly and association of the structural elements of a bacterial pilus depend on two specialized tip proteins." ]

[ 1992, 1995, 1993 ]

3

[]

0

null

[ "Bacteria", "Mesangiospermae" ]

[ 300, 2 ]

2

[]

0

true

Family

P pili tip fibrillum PapF protein

P_pili_tip_PapF

3

IPR005431

5,431

Gamma-aminobutyric-acid A receptor, alpha 1 subunit

GABBAa1_rcpt

Family

823

false

Neurotransmitter ligand-gated ion channels are transmembrane receptor-ion channel complexes that open transiently upon binding of specific ligands, allowing rapid transmission of signals at chemical synapses [ , ]. Five of these ion channel receptor families have been shown to form a sequence-related superfamily: Nicot...

[ "GO:0004890", "GO:0006821", "GO:0007214", "GO:0016020" ]

[ "GABA-A receptor activity", "chloride transport", "gamma-aminobutyric acid signaling pathway", "membrane" ]

[ "molecular_function", "biological_process", "biological_process", "cellular_component" ]

4

[ "PRINTS" ]

[ "PR01614" ]

[ "GABAARALPHA1" ]

[ 823 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-977443", "R-GGA-977443", "R-HSA-1236394", "R-HSA-977443", "R-MMU-977443", "R-RNO-977443" ]

[ "REACTOME:R-BTA-977443", "REACTOME:R-GGA-977443", "REACTOME:R-HSA-1236394", "REACTOME:R-HSA-977443", "REACTOME:R-MMU-977443", "REACTOME:R-RNO-977443" ]

6

[ "6hug", "6huj", "6huk", "6huo", "6hup", "6i53", "7qne", "8foi", "8g4n", "8g4o", "8g4x", "8g5f", "8g5g", "8g5h", "8pet", "9crs", "9crv", "9csb", "9ct0", "9ctj", "9ctp", "9ctv", "9cx7", "9cxa", "9cxb", "9cxc", "9cxd", "9eqg", "9faj", "9fak", "9fam", "9fap"...

49

[ "PUB00002675", "PUB00003455", "PUB00007821", "PUB00007822", "PUB00007823", "PUB00007824", "PUB00009393", "PUB00009394", "PUB00010340", "PUB00044612", "PUB00044613", "PUB00044614", "PUB00044615" ]

[ "1721053", "1846404", "11712530", "8537206", "9647870", "11282419", "10449790", "2538761", "10026168", "18446614", "15383648", "18760291", "15165736" ]

[ "Determination of the tyrosine phosphorylation sites of the nicotinic acetylcholine receptor.", "Generation of two forms of the gamma-aminobutyric acidA receptor gamma 2-subunit in mice by alternative splicing.", "GABA(A)-receptor subtypes: a new pharmacology.", "Structure and pharmacology of vertebrate GABAA...

[ 1991, 1991, 2001, 1995, 1998, 2001, 1999, 1989, 1999, 2008, 2004, 2008, 2004 ]

13

[ "IPR001390" ]

[]

1

0

1

[ "Gnathostomata" ]

[ 823 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 5, 3, 4 ]

4

true

Family

Gamma-aminobutyric-acid A receptor, alpha 1 subunit

GABBAa1_rcpt

7

IPR005432

5,432

Gamma-aminobutyric-acid A receptor, alpha 2 subunit

GABBAa2_rcpt

Family

1,315

false

Amongst type II members, alpha 2-containing receptors have a very similar BZ affinity profile to those containing the alpha 3 subunit. Differences in efficacy can be exploited to differentiate such subtypes: for example, the compound flunitrazepam has a greater efficacy on the alpha 2 subtype. Alpha 2-containing recept...

[ "GO:0004890", "GO:0006821", "GO:0007214", "GO:0016020" ]

[ "GABA-A receptor activity", "chloride transport", "gamma-aminobutyric acid signaling pathway", "membrane" ]

[ "molecular_function", "biological_process", "biological_process", "cellular_component" ]

4

[ "PRINTS" ]

[ "PR01615" ]

[ "GABAARALPHA2" ]

[ 1315 ]

1

[ "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-977443", "R-MMU-977443", "R-RNO-977443" ]

[ "REACTOME:R-HSA-977443", "REACTOME:R-MMU-977443", "REACTOME:R-RNO-977443" ]

3

[ "9crv", "9csb", "9ct0", "9ctj", "9ctv", "9cx7", "9cxb", "9cxc" ]

8

[ "PUB00002675", "PUB00003455", "PUB00007821", "PUB00007822", "PUB00007823", "PUB00007824", "PUB00009393", "PUB00009394", "PUB00010340", "PUB00044612", "PUB00044613", "PUB00044614", "PUB00044615" ]

[ "1721053", "1846404", "11712530", "8537206", "9647870", "11282419", "10449790", "2538761", "10026168", "18446614", "15383648", "18760291", "15165736" ]

[ "Determination of the tyrosine phosphorylation sites of the nicotinic acetylcholine receptor.", "Generation of two forms of the gamma-aminobutyric acidA receptor gamma 2-subunit in mice by alternative splicing.", "GABA(A)-receptor subtypes: a new pharmacology.", "Structure and pharmacology of vertebrate GABAA...

[ 1991, 1991, 2001, 1995, 1998, 2001, 1999, 1989, 1999, 2008, 2004, 2008, 2004 ]

13

[ "IPR001390" ]

[]

1

0

1

[ "Gnathostomata" ]

[ 1315 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 5, 3, 5 ]

4

true

Family

Gamma-aminobutyric-acid A receptor, alpha 2 subunit

GABBAa2_rcpt

4

IPR005433

5,433

Gamma-aminobutyric-acid A receptor, alpha 3 subunit

GABBAa3_rcpt

Family

340

false

Amongst type II members, alpha 2-containing receptors have a very similar BZ affinity profile to those containing the alpha 3 subunit. Differences in efficacy can be exploited to differentiate such subtypes: for example, the compound flunitrazepam has a greater efficacy on the alpha 2 subtype. Alpha 3-containing recept...

[ "GO:0004890", "GO:0006821", "GO:0007214", "GO:0016020" ]

[ "GABA-A receptor activity", "chloride transport", "gamma-aminobutyric acid signaling pathway", "membrane" ]

[ "molecular_function", "biological_process", "biological_process", "cellular_component" ]

4

[ "PRINTS" ]

[ "PR01616" ]

[ "GABAARALPHA3" ]

[ 340 ]

1

[ "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-977443", "R-MMU-977443", "R-RNO-977443" ]

[ "REACTOME:R-HSA-977443", "REACTOME:R-MMU-977443", "REACTOME:R-RNO-977443" ]

3

[ "8g4x", "8g5f", "8g5g", "8g5h", "9ctp" ]

5

[ "PUB00002675", "PUB00003455", "PUB00007821", "PUB00007822", "PUB00007823", "PUB00007824", "PUB00009393", "PUB00009394", "PUB00010340", "PUB00044612", "PUB00044613", "PUB00044614", "PUB00044615" ]

[ "1721053", "1846404", "11712530", "8537206", "9647870", "11282419", "10449790", "2538761", "10026168", "18446614", "15383648", "18760291", "15165736" ]

[ "Determination of the tyrosine phosphorylation sites of the nicotinic acetylcholine receptor.", "Generation of two forms of the gamma-aminobutyric acidA receptor gamma 2-subunit in mice by alternative splicing.", "GABA(A)-receptor subtypes: a new pharmacology.", "Structure and pharmacology of vertebrate GABAA...

[ 1991, 1991, 2001, 1995, 1998, 2001, 1999, 1989, 1999, 2008, 2004, 2008, 2004 ]

13

[ "IPR001390" ]

[]

1

0

1

[ "Bilateria" ]

[ 340 ]

1

[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 3, 4 ]

3

true

Family

Gamma-aminobutyric-acid A receptor, alpha 3 subunit

GABBAa3_rcpt

3

IPR005434

5,434

Gamma-aminobutyric-acid A receptor, alpha 4 subunit

GABBAa4_rcpt

Family

627

false

Alpha 4-and 6-containing receptors are often referred to as `diazepam-insensitive' receptors, since inclusion of such subunits in place of type I and II polypeptides virtually eliminates sensitivity to BZs. The alpha 4 receptor subtype is localised primarily in the thalamus [ ]. Neurotransmitter ligand-gated ion channe...

[ "GO:0004890", "GO:0006821", "GO:0007214", "GO:0016020" ]

[ "GABA-A receptor activity", "chloride transport", "gamma-aminobutyric acid signaling pathway", "membrane" ]

[ "molecular_function", "biological_process", "biological_process", "cellular_component" ]

4

[ "PRINTS" ]

[ "PR01617" ]

[ "GABAARALPHA4" ]

[ 627 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-977443", "R-HSA-977443", "R-MMU-977443", "R-RNO-977443" ]

[ "REACTOME:R-BTA-977443", "REACTOME:R-HSA-977443", "REACTOME:R-MMU-977443", "REACTOME:R-RNO-977443" ]

4

[ "7qn5", "7qn7", "7qn9", "7qna", "7qnc" ]

5

[ "PUB00002675", "PUB00003455", "PUB00007821", "PUB00007822", "PUB00007823", "PUB00007824", "PUB00009393", "PUB00009394", "PUB00010340", "PUB00044612", "PUB00044613", "PUB00044614", "PUB00044615" ]

[ "1721053", "1846404", "11712530", "8537206", "9647870", "11282419", "10449790", "2538761", "10026168", "18446614", "15383648", "18760291", "15165736" ]

[ "Determination of the tyrosine phosphorylation sites of the nicotinic acetylcholine receptor.", "Generation of two forms of the gamma-aminobutyric acidA receptor gamma 2-subunit in mice by alternative splicing.", "GABA(A)-receptor subtypes: a new pharmacology.", "Structure and pharmacology of vertebrate GABAA...

[ 1991, 1991, 2001, 1995, 1998, 2001, 1999, 1989, 1999, 2008, 2004, 2008, 2004 ]

13

[ "IPR001390" ]

[]

1

0

1

[ "Gnathostomata" ]

[ 627 ]

1

[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 4, 2 ]

3

true

Family

Gamma-aminobutyric-acid A receptor, alpha 4 subunit

GABBAa4_rcpt

4

IPR005435

5,435

Gamma-aminobutyric-acid A receptor, alpha 5 subunit

GABBAa5_rcpt

Family

660

false

Neurotransmitter ligand-gated ion channels are transmembrane receptor-ion channel complexes that open transiently upon binding of specific ligands, allowing rapid transmission of signals at chemical synapses [ , ]. Five of these ion channel receptor families have been shown to form a sequence-related superfamily: Nicot...

[ "GO:0004890", "GO:0006821", "GO:0007214", "GO:0016020" ]

[ "GABA-A receptor activity", "chloride transport", "gamma-aminobutyric acid signaling pathway", "membrane" ]

[ "molecular_function", "biological_process", "biological_process", "cellular_component" ]

4

[ "PRINTS" ]

[ "PR01618" ]

[ "GABAARALPHA5" ]

[ 660 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-977443", "R-HSA-977443", "R-MMU-977443", "R-RNO-977443" ]

[ "REACTOME:R-BTA-977443", "REACTOME:R-HSA-977443", "REACTOME:R-MMU-977443", "REACTOME:R-RNO-977443" ]

4

[ "6a96" ]

1

[ "PUB00002675", "PUB00003455", "PUB00007821", "PUB00007822", "PUB00007823", "PUB00007824", "PUB00009393", "PUB00009394", "PUB00010340", "PUB00044612", "PUB00044613", "PUB00044614", "PUB00044615" ]

[ "1721053", "1846404", "11712530", "8537206", "9647870", "11282419", "10449790", "2538761", "10026168", "18446614", "15383648", "18760291", "15165736" ]

[ "Determination of the tyrosine phosphorylation sites of the nicotinic acetylcholine receptor.", "Generation of two forms of the gamma-aminobutyric acidA receptor gamma 2-subunit in mice by alternative splicing.", "GABA(A)-receptor subtypes: a new pharmacology.", "Structure and pharmacology of vertebrate GABAA...

[ 1991, 1991, 2001, 1995, 1998, 2001, 1999, 1989, 1999, 2008, 2004, 2008, 2004 ]

13

[ "IPR001390" ]

[]

1

0

1

[ "Euteleostomi" ]

[ 660 ]

1

[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 6, 1, 3 ]

3

true

Family

Gamma-aminobutyric-acid A receptor, alpha 5 subunit

GABBAa5_rcpt

9

IPR005436

5,436

Gamma-aminobutyric-acid A receptor, alpha 6 subunit

GABBAa6_rcpt

Family

356

false

Neurotransmitter ligand-gated ion channels are transmembrane receptor-ion channel complexes that open transiently upon binding of specific ligands, allowing rapid transmission of signals at chemical synapses [ , ]. Five of these ion channel receptor families have been shown to form a sequence-related superfamily: Nicot...

[ "GO:0004890", "GO:0006821", "GO:0007214", "GO:0016020" ]

[ "GABA-A receptor activity", "chloride transport", "gamma-aminobutyric acid signaling pathway", "membrane" ]

[ "molecular_function", "biological_process", "biological_process", "cellular_component" ]

4

[ "PRINTS" ]

[ "PR01619" ]

[ "GABAARALPHA6" ]

[ 356 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-GGA-977443", "R-HSA-977443", "R-MMU-977443", "R-RNO-977443" ]

[ "REACTOME:R-GGA-977443", "REACTOME:R-HSA-977443", "REACTOME:R-MMU-977443", "REACTOME:R-RNO-977443" ]

4

[]

0

[ "PUB00002675", "PUB00003455", "PUB00007821", "PUB00007822", "PUB00007823", "PUB00007824", "PUB00009393", "PUB00009394", "PUB00010340", "PUB00044612", "PUB00044613", "PUB00044614", "PUB00044615" ]

[ "1721053", "1846404", "11712530", "8537206", "9647870", "11282419", "10449790", "2538761", "10026168", "18446614", "15383648", "18760291", "15165736" ]

[ "Determination of the tyrosine phosphorylation sites of the nicotinic acetylcholine receptor.", "Generation of two forms of the gamma-aminobutyric acidA receptor gamma 2-subunit in mice by alternative splicing.", "GABA(A)-receptor subtypes: a new pharmacology.", "Structure and pharmacology of vertebrate GABAA...

[ 1991, 1991, 2001, 1995, 1998, 2001, 1999, 1989, 1999, 2008, 2004, 2008, 2004 ]

13

[ "IPR001390" ]

[]

1

0

1

[ "Amniota" ]

[ 356 ]

1

[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 4, 2, 4 ]

3

true

Family

Gamma-aminobutyric-acid A receptor, alpha 6 subunit

GABBAa6_rcpt

6

IPR005437

5,437

Gamma-aminobutyric acid receptor subunit gamma-1/4

GABRG-1/4

Family

3,954

false

Neurotransmitter ligand-gated ion channels are transmembrane receptor-ion channel complexes that open transiently upon binding of specific ligands, allowing rapid transmission of signals at chemical synapses [ , ]. Five of these ion channel receptor families have been shown to form a sequence-related superfamily: Nicot...

[ "GO:0004890", "GO:0006821", "GO:0007214", "GO:0016020" ]

[ "GABA-A receptor activity", "chloride transport", "gamma-aminobutyric acid signaling pathway", "membrane" ]

[ "molecular_function", "biological_process", "biological_process", "cellular_component" ]

4

[ "PRINTS" ]

[ "PR01620" ]

[ "GABAARGAMMA" ]

[ 3954 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-GGA-977443", "R-HSA-1236394", "R-HSA-977443", "R-MMU-977443", "R-RNO-977443" ]

[ "REACTOME:R-GGA-977443", "REACTOME:R-HSA-1236394", "REACTOME:R-HSA-977443", "REACTOME:R-MMU-977443", "REACTOME:R-RNO-977443" ]

5

[ "6d6t", "6d6u", "6dw0", "6dw1", "6hug", "6huj", "6huk", "6huo", "6hup", "6i53", "6x3s", "6x3t", "6x3u", "6x3v", "6x3w", "6x3x", "6x3z", "6x40", "7qna", "7qnb", "7qne", "7t0w", "7t0z", "8bhg", "8dd2", "8dd3", "8foi", "8g4n", "8g4o", "8g4x", "8g5f", "8g5g"...

82

[ "PUB00002675", "PUB00003455", "PUB00007821", "PUB00007822", "PUB00007823", "PUB00007824", "PUB00009393", "PUB00009394", "PUB00010340", "PUB00044612", "PUB00044613", "PUB00044614", "PUB00044615" ]

[ "1721053", "1846404", "11712530", "8537206", "9647870", "11282419", "10449790", "2538761", "10026168", "18446614", "15383648", "18760291", "15165736" ]

[ "Determination of the tyrosine phosphorylation sites of the nicotinic acetylcholine receptor.", "Generation of two forms of the gamma-aminobutyric acidA receptor gamma 2-subunit in mice by alternative splicing.", "GABA(A)-receptor subtypes: a new pharmacology.", "Structure and pharmacology of vertebrate GABAA...

[ 1991, 1991, 2001, 1995, 1998, 2001, 1999, 1989, 1999, 2008, 2004, 2008, 2004 ]

13

[ "IPR006028" ]

[ "IPR005438", "IPR005439", "IPR005440" ]

1

3

0

[ "Eumetazoa" ]

[ 3954 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 17, 21, 9, 12 ]

4

true

Family

Gamma-aminobutyric acid receptor subunit gamma-1/4

GABRG-1/4

6

IPR005438

5,438

Gamma-aminobutyric-acid A receptor, gamma 1 subunit

GABBAg1_rcpt

Family

162

false

Neurotransmitter ligand-gated ion channels are transmembrane receptor-ion channel complexes that open transiently upon binding of specific ligands, allowing rapid transmission of signals at chemical synapses [ , ]. Five of these ion channel receptor families have been shown to form a sequence-related superfamily: Nicot...

[ "GO:0004890", "GO:0006821", "GO:0007214", "GO:0016020" ]

[ "GABA-A receptor activity", "chloride transport", "gamma-aminobutyric acid signaling pathway", "membrane" ]

[ "molecular_function", "biological_process", "biological_process", "cellular_component" ]

4

[ "PRINTS" ]

[ "PR01621" ]

[ "GABAARGAMMA1" ]

[ 162 ]

1

[]

0

[]

0

[ "PUB00002675", "PUB00003455", "PUB00007821", "PUB00007822", "PUB00007823", "PUB00007824", "PUB00009393", "PUB00009394", "PUB00010340", "PUB00044612", "PUB00044613", "PUB00044614", "PUB00044615" ]

[ "1721053", "1846404", "11712530", "8537206", "9647870", "11282419", "10449790", "2538761", "10026168", "18446614", "15383648", "18760291", "15165736" ]

[ "Determination of the tyrosine phosphorylation sites of the nicotinic acetylcholine receptor.", "Generation of two forms of the gamma-aminobutyric acidA receptor gamma 2-subunit in mice by alternative splicing.", "GABA(A)-receptor subtypes: a new pharmacology.", "Structure and pharmacology of vertebrate GABAA...

[ 1991, 1991, 2001, 1995, 1998, 2001, 1999, 1989, 1999, 2008, 2004, 2008, 2004 ]

13

[ "IPR005437" ]

[]

1

0

1

[ "Amniota" ]

[ 162 ]

1

[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 3, 2, 3 ]

3

true

Family

Gamma-aminobutyric-acid A receptor, gamma 1 subunit

GABBAg1_rcpt

4

IPR005440

5,440

Gamma-aminobutyric-acid A receptor, gamma 3 subunit

GABBAg3_rcpt

Family

265

false

Neurotransmitter ligand-gated ion channels are transmembrane receptor-ion channel complexes that open transiently upon binding of specific ligands, allowing rapid transmission of signals at chemical synapses [ , ]. Five of these ion channel receptor families have been shown to form a sequence-related superfamily: Nicot...

[ "GO:0004890", "GO:0006821", "GO:0007214", "GO:0016020" ]

[ "GABA-A receptor activity", "chloride transport", "gamma-aminobutyric acid signaling pathway", "membrane" ]

[ "molecular_function", "biological_process", "biological_process", "cellular_component" ]

4

[ "PRINTS" ]

[ "PR01623" ]

[ "GABAARGAMMA3" ]

[ 265 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-1236394", "R-HSA-977443", "R-MMU-977443", "R-RNO-977443" ]

[ "REACTOME:R-HSA-1236394", "REACTOME:R-HSA-977443", "REACTOME:R-MMU-977443", "REACTOME:R-RNO-977443" ]

4

[]

0

[ "PUB00002675", "PUB00003455", "PUB00007821", "PUB00007822", "PUB00007823", "PUB00007824", "PUB00009393", "PUB00009394", "PUB00010340", "PUB00044612", "PUB00044613", "PUB00044614", "PUB00044615" ]

[ "1721053", "1846404", "11712530", "8537206", "9647870", "11282419", "10449790", "2538761", "10026168", "18446614", "15383648", "18760291", "15165736" ]

[ "Determination of the tyrosine phosphorylation sites of the nicotinic acetylcholine receptor.", "Generation of two forms of the gamma-aminobutyric acidA receptor gamma 2-subunit in mice by alternative splicing.", "GABA(A)-receptor subtypes: a new pharmacology.", "Structure and pharmacology of vertebrate GABAA...

[ 1991, 1991, 2001, 1995, 1998, 2001, 1999, 1989, 1999, 2008, 2004, 2008, 2004 ]

13

[ "IPR005437" ]

[]

1

0

1

[ "Euteleostomi" ]

[ 265 ]

1

[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 3, 1, 3 ]

3

true

Family

Gamma-aminobutyric-acid A receptor, gamma 3 subunit

GABBAg3_rcpt

4

IPR005441

5,441

Preproghrelin peptide

Preproghrelin

Family

780

false

Growth hormone (GH) is a pituitary hormone involved in cell and overall body growth, carbohydrate-protein-lipid metabolism and osmotic homeostasis. Control of GH release was initially ascribed to 2 pathways: stimulation by hypothalamic GH-releasing hormone (GHRH) and inhibition by somatostatin. More recently, synthetic...

[ "GO:0016608", "GO:0005576" ]

[ "growth hormone-releasing hormone activity", "extracellular region" ]

[ "molecular_function", "cellular_component" ]

2

[ "PRINTS", "PANTHER" ]

[ "PR01624", "PTHR14122" ]

[ "GHRELIN", "" ]

[ 587, 775 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-416476", "R-BTA-422085", "R-CFA-416476", "R-CFA-422085", "R-HSA-375276", "R-HSA-416476", "R-HSA-422085", "R-MMU-416476", "R-MMU-422085", "R-RNO-416476", "R-RNO-422085", "R-SSC-416476", "R-SSC-422085" ]

[ "REACTOME:R-BTA-416476", "REACTOME:R-BTA-422085", "REACTOME:R-CFA-416476", "REACTOME:R-CFA-422085", "REACTOME:R-HSA-375276", "REACTOME:R-HSA-416476", "REACTOME:R-HSA-422085", "REACTOME:R-MMU-416476", "REACTOME:R-MMU-422085", "REACTOME:R-RNO-416476", "REACTOME:R-RNO-422085", "REACTOME:R-SSC-416...

13

[ "7f9y" ]

1

[ "PUB00007825", "PUB00007826", "PUB00007827" ]

[ "11306336", "10604470", "11483998" ]

[ "Ghrelin: discovery of the natural endogenous ligand for the growth hormone secretagogue receptor.", "Ghrelin is a growth-hormone-releasing acylated peptide from stomach.", "Ghrelin: an orexigenic and somatotrophic signal from the stomach." ]

[ 2001, 1999, 2001 ]

3

[]

0

null

[ "Euteleostomi" ]

[ 780 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 7, 5, 4 ]

4

true

Family

Preproghrelin peptide

Preproghrelin

8

IPR005442

5,442

Glutathione S-transferase, omega-class

GST_omega

Family

4,780

false

Glutathione S-transferases (GSTs) are soluble proteins with typical molecular masses of around 50kDa, each composed of two polypeptide subunits. GSTs catalyse the transfer of the tripeptide glutathione (gamma-glutamyl-cysteinyl-glycine; GSH) to a co-substrate (R-X) containing a reactive electrophillic centre to form a ...

[ "GO:0004364", "GO:0005737" ]

[ "glutathione transferase activity", "cytoplasm" ]

[ "molecular_function", "cellular_component" ]

2

[ "PRINTS" ]

[ "PR01625" ]

[ "GSTRNSFRASEO" ]

[ 4780 ]

1

[ "EC", "EC", "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REAC...

[ "1.20.4.2", "1.8.5.1", "2.5.1.18", "PWY-2261", "PWY-4061", "PWY-4202", "PWY-6370", "PWY-6842", "PWY-7112", "PWY-7533", "R-CEL-156581", "R-CEL-156590", "R-CEL-196836", "R-DME-156581", "R-DME-156590", "R-DME-196836", "R-HSA-156581", "R-HSA-156590", "R-HSA-196836", "R-HSA-8950505"...

[ "EC:1.20.4.2", "EC:1.8.5.1", "EC:2.5.1.18", "METACYC:PWY-2261", "METACYC:PWY-4061", "METACYC:PWY-4202", "METACYC:PWY-6370", "METACYC:PWY-6842", "METACYC:PWY-7112", "METACYC:PWY-7533", "REACTOME:R-CEL-156581", "REACTOME:R-CEL-156590", "REACTOME:R-CEL-196836", "REACTOME:R-DME-156581", "REA...

29

[ "1eem", "3lfl", "3q18", "3q19", "3qag", "3rbt", "3vln", "3wd6", "4is0", "4pqi", "4qq7", "4yqm", "4yqu", "4yqv", "5ueh", "5v3q", "5yvn", "5yvo", "6mhb", "6mhc", "6mhd", "6pnm", "6pnn", "6pno", "8qll" ]

25

[ "PUB00007307" ]

[ "10783391" ]

[ "Identification, characterization, and crystal structure of the Omega class glutathione transferases." ]

[ 2000 ]

1

[ "IPR040079" ]

[]

1

0

1

[ "Bacteria", "Eukaryota", "ecological metagenomes" ]

[ 253, 4518, 9 ]

3

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus", "Zea mays" ]

[ 5, 3, 8, 6, 8, 10, 2 ]

7

true

Family

Glutathione S-transferase, omega-class

GST_omega

1

IPR005443

5,443

Voltage-dependent calcium channel, L-type, beta-1 subunit

VDCC_L_b1su

Family

1,383

false

Ca2+ ions are unique in that they not only carry charge but they are also the most widely used of diffusible second messengers. Voltage-dependent Ca2+ channels (VDCC) are a family of molecules that allow cells to couple electrical activity to intracellular Ca2+ signalling. The opening and closing of these channels by d...

[ "GO:0005245", "GO:0070588", "GO:0005891" ]

[ "voltage-gated calcium channel activity", "calcium ion transmembrane transport", "voltage-gated calcium channel complex" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PRINTS" ]

[ "PR01627" ]

[ "LCACHANNELB1" ]

[ 1383 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-112308", "R-BTA-5576892", "R-BTA-5576893", "R-HSA-112308", "R-HSA-419037", "R-HSA-5576892", "R-HSA-5576893", "R-HSA-9856532", "R-MMU-112308", "R-MMU-5576892", "R-MMU-5576893", "R-RNO-112308", "R-RNO-5576892", "R-RNO-5576893" ]

[ "REACTOME:R-BTA-112308", "REACTOME:R-BTA-5576892", "REACTOME:R-BTA-5576893", "REACTOME:R-HSA-112308", "REACTOME:R-HSA-419037", "REACTOME:R-HSA-5576892", "REACTOME:R-HSA-5576893", "REACTOME:R-HSA-9856532", "REACTOME:R-MMU-112308", "REACTOME:R-MMU-5576892", "REACTOME:R-MMU-5576893", "REACTOME:R-...

14

[ "4zw2", "5gjv", "5gjw", "6jp5", "6jp8", "6jpa", "6jpb", "7vfs", "7vfu", "7vfv", "7vfw", "7xlq", "7yg5", "8dam" ]

14

[ "PUB00007090", "PUB00007828", "PUB00036034" ]

[ "9153247", "9560220", "14657414" ]

[ "Beta subunit heterogeneity in neuronal L-type Ca2+ channels.", "Association of calcium channel alpha1S and beta1a subunits is required for the targeting of beta1a but not of alpha1S into skeletal muscle triads.", "International Union of Pharmacology. XL. Compendium of voltage-gated ion channels: calcium channe...

[ 1997, 1998, 2003 ]

3

[ "IPR000584" ]

[]

1

0

1

[ "Gnathostomata" ]

[ 1383 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 5, 5, 7, 5 ]

4

true

Family

Voltage-dependent calcium channel, L-type, beta-1 subunit

VDCC_L_b1su

1

IPR005444

5,444

Voltage-dependent calcium channel, L-type, beta-2 subunit

VDCC_L_b2su

Family

2,499

false

Ca2+ ions are unique in that they not only carry charge but they are also the most widely used of diffusible second messengers. Voltage-dependent Ca2+ channels (VDCC) are a family of molecules that allow cells to couple electrical activity to intracellular Ca2+ signalling. The opening and closing of these channels by d...

[ "GO:0005245", "GO:0070588", "GO:0005891" ]

[ "voltage-gated calcium channel activity", "calcium ion transmembrane transport", "voltage-gated calcium channel complex" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PRINTS" ]

[ "PR01628" ]

[ "LCACHANNELB2" ]

[ 2499 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-112308", "R-BTA-422356", "R-BTA-5576892", "R-BTA-5576893", "R-HSA-112308", "R-HSA-400042", "R-HSA-419037", "R-HSA-422356", "R-HSA-5576892", "R-HSA-5576893", "R-HSA-9662360", "R-HSA-9856532", "R-MMU-112308", "R-MMU-422356", "R-MMU-5576892", "R-MMU-5576893", "R-RNO-112308", "R...

[ "REACTOME:R-BTA-112308", "REACTOME:R-BTA-422356", "REACTOME:R-BTA-5576892", "REACTOME:R-BTA-5576893", "REACTOME:R-HSA-112308", "REACTOME:R-HSA-400042", "REACTOME:R-HSA-419037", "REACTOME:R-HSA-422356", "REACTOME:R-HSA-5576892", "REACTOME:R-HSA-5576893", "REACTOME:R-HSA-9662360", "REACTOME:R-HS...

20

[ "1t0h", "1t0j", "1t3l", "1t3s", "3jbr", "4dex", "4dey", "8hlp", "8hma", "8hmb" ]

10

[ "PUB00007090", "PUB00018859", "PUB00036034" ]

[ "9153247", "11604404", "14657414" ]

[ "Beta subunit heterogeneity in neuronal L-type Ca2+ channels.", "Cloning of a functional splice variant of L-type calcium channel beta 2 subunit from rat heart.", "International Union of Pharmacology. XL. Compendium of voltage-gated ion channels: calcium channels." ]

[ 1997, 2001, 2003 ]

3

[ "IPR000584" ]

[]

1

0

1

[ "Chordata" ]

[ 2499 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 9, 19, 8, 15 ]

4

true

Family

Voltage-dependent calcium channel, L-type, beta-2 subunit

VDCC_L_b2su

4

IPR005445

5,445

Voltage-dependent calcium channel, T-type, alpha-1 subunit

VDCC_T_a1

Family

6,560

false

Ca2+ ions are unique in that they not only carry charge but they are also the most widely used of diffusible second messengers. Voltage-dependent Ca2+ channels (VDCC) are a family of molecules that allow cells to couple electrical activity to intracellular Ca2+ signalling. The opening and closing of these channels by d...

[ "GO:0005245", "GO:0070588", "GO:0005891" ]

[ "voltage-gated calcium channel activity", "calcium ion transmembrane transport", "voltage-gated calcium channel complex" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PRINTS" ]

[ "PR01629" ]

[ "TVDCCALPHA1" ]

[ 6560 ]

1

[ "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-419037", "R-HSA-445355", "R-HSA-9856532" ]

[ "REACTOME:R-HSA-419037", "REACTOME:R-HSA-445355", "REACTOME:R-HSA-9856532" ]

3

[ "6kzo", "6kzp", "7wli", "7wlj", "7wlk", "7wll", "9ayg", "9ayh", "9ayj", "9ayk", "9ayl" ]

11

[ "PUB00007829", "PUB00007830", "PUB00007831", "PUB00036034", "PUB00036040", "PUB00036041" ]

[ "8815798", "8232302", "2557425", "14657414", "11031246", "10774722" ]

[ "Low-threshold calcium currents in central nervous system neurons.", "T-type Ca2+ channels are required for adrenocorticotropin-stimulated cortisol production by bovine adrenal zona fasciculata cells.", "Dihydropyridine-sensitive low-threshold calcium channels in isolated rat hypothalamic neurones.", "Interna...

[ 1996, 1993, 1989, 2003, 2000, 2000 ]

6

[]

0

null

[ "Eumetazoa" ]

[ 6560 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 5, 24, 5, 29, 23, 22 ]

6

true

Family

Voltage-dependent calcium channel, T-type, alpha-1 subunit

VDCC_T_a1

7

IPR005446

5,446

Voltage-dependent calcium channel, L-type, alpha-1 subunit

VDCC_L_a1su

Family

9,790

false

Ca2+ ions are unique in that they not only carry charge but they are also the most widely used of diffusible second messengers. Voltage-dependent Ca2+ channels (VDCC) are a family of molecules that allow cells to couple electrical activity to intracellular Ca2+ signalling. The opening and closing of these channels by d...

[ "GO:0005245", "GO:0070588", "GO:0005891" ]

[ "voltage-gated calcium channel activity", "calcium ion transmembrane transport", "voltage-gated calcium channel complex" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PRINTS" ]

[ "PR01630" ]

[ "LVDCCALPHA1" ]

[ 9790 ]

1

[ "GP", "GP", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "GenProp2095", "GenProp2099", "R-DME-422356", "R-DME-5576892", "R-DME-5576893", "R-GGA-422356", "R-HSA-400042", "R-HSA-419037", "R-HSA-422356", "R-HSA-5576892", "R-HSA-5576893", "R-HSA-9662360", "R-MMU-422356", "R-MMU-5576892", "R-MMU-5576893", "R-RNO-422356", "R-RNO-5576892", "R-R...

[ "GP:GenProp2095", "GP:GenProp2099", "REACTOME:R-DME-422356", "REACTOME:R-DME-5576892", "REACTOME:R-DME-5576893", "REACTOME:R-GGA-422356", "REACTOME:R-HSA-400042", "REACTOME:R-HSA-419037", "REACTOME:R-HSA-422356", "REACTOME:R-HSA-5576892", "REACTOME:R-HSA-5576893", "REACTOME:R-HSA-9662360", "...

18

[ "3jbr", "4dey", "5gjv", "5gjw", "6byo", "6jp5", "6jp8", "6jpa", "6jpb", "7jpk", "7jpl", "7jpv", "7jpw", "7jpx", "7uhf", "7uhg", "8e56", "8e57", "8e58", "8e59", "8e5a", "8e5b", "8eog", "8eoi", "8fd7", "8fhs", "8hlp", "8hma", "8hmb", "8we6", "8we7", "8we8"...

34

[ "PUB00036034", "PUB00036040", "PUB00036041", "PUB00036043", "PUB00071805" ]

[ "14657414", "11031246", "10774722", "12825828", "15336981" ]

[ "International Union of Pharmacology. XL. Compendium of voltage-gated ion channels: calcium channels.", "Structure and regulation of voltage-gated Ca2+ channels.", "Nomenclature of voltage-gated calcium channels.", "1,4-Dihydropyridines as calcium channel ligands and privileged structures.", "L-type Ca2+ ch...

[ 2003, 2000, 2000, 2003, 2004 ]

5

[ "IPR002077" ]

[ "IPR005450", "IPR005451", "IPR005452" ]

1

3

0

[ "Eukaryota", "bird metagenome" ]

[ 9789, 1 ]

2

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 123, 9, 36, 42, 45 ]

6

true

Family

Voltage-dependent calcium channel, L-type, alpha-1 subunit

VDCC_L_a1su

1

IPR005447

5,447

Voltage-dependent calcium channel, N-type, alpha-1 subunit

VDCC_N_a1su

Family

2,175

false

Ca2+ ions are unique in that they not only carry charge but they are also the most widely used of diffusible second messengers. Voltage-dependent Ca2+ channels (VDCC) are a family of molecules that allow cells to couple electrical activity to intracellular Ca2+ signalling. The opening and closing of these channels by d...

[ "GO:0005245", "GO:0070588", "GO:0005891" ]

[ "voltage-gated calcium channel activity", "calcium ion transmembrane transport", "voltage-gated calcium channel complex" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PRINTS" ]

[ "PR01631" ]

[ "NVDCCALPHA1" ]

[ 2175 ]

1

[ "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-112308", "R-MMU-112308", "R-RNO-112308" ]

[ "REACTOME:R-HSA-112308", "REACTOME:R-MMU-112308", "REACTOME:R-RNO-112308" ]

3

[ "7mix", "7miy", "7vfs", "7vfu", "7vfv", "7vfw" ]

6

[ "PUB00018861", "PUB00018862", "PUB00036034", "PUB00036040", "PUB00036041", "PUB00036079", "PUB00036080", "PUB00100492" ]

[ "8415733", "2447647", "14657414", "11031246", "10774722", "7902110", "16489373", "34234349" ]

[ "Multiple Ca2+ channel types coexist to regulate synaptosomal neurotransmitter release.", "Dominant role of N-type Ca2+ channels in evoked release of norepinephrine from sympathetic neurons.", "International Union of Pharmacology. XL. Compendium of voltage-gated ion channels: calcium channels.", "Structure an...

[ 1993, 1988, 2003, 2000, 2000, 1993, 2005, 2021 ]

8

[ "IPR002077" ]

[]

1

0

1

[ "Vertebrata" ]

[ 2175 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 16, 11, 5, 13 ]

4

true

Family

Voltage-dependent calcium channel, N-type, alpha-1 subunit

VDCC_N_a1su

6

IPR005448

5,448

Voltage-dependent calcium channel, P/Q-type, alpha-1 A

CACNA1A

Family

768

false

Ca2+ ions are unique in that they not only carry charge but they are also the most widely used of diffusible second messengers. Voltage-dependent Ca2+ channels (VDCC) are a family of molecules that allow cells to couple electrical activity to intracellular Ca2+ signalling. The opening and closing of these channels by d...

[ "GO:0005245", "GO:0070588", "GO:0005891" ]

[ "voltage-gated calcium channel activity", "calcium ion transmembrane transport", "voltage-gated calcium channel complex" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PRINTS" ]

[ "PR01632" ]

[ "PQVDCCALPHA1" ]

[ 768 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-112308", "R-HSA-422356", "R-MMU-112308", "R-MMU-422356", "R-RNO-112308", "R-RNO-422356" ]

[ "REACTOME:R-HSA-112308", "REACTOME:R-HSA-422356", "REACTOME:R-MMU-112308", "REACTOME:R-MMU-422356", "REACTOME:R-RNO-112308", "REACTOME:R-RNO-422356" ]

6

[ "8x90", "8x91", "8x93" ]

3

[ "PUB00007832", "PUB00036034", "PUB00036040", "PUB00036041" ]

[ "8825650", "14657414", "11031246", "10774722" ]

[ "Chromosomal localization of the human genes for alpha 1A, alpha 1B, and alpha 1E voltage-dependent Ca2+ channel subunits.", "International Union of Pharmacology. XL. Compendium of voltage-gated ion channels: calcium channels.", "Structure and regulation of voltage-gated Ca2+ channels.", "Nomenclature of volt...

[ 1995, 2003, 2000, 2000 ]

4

[ "IPR002077" ]

[]

1

0

1

[ "Eukaryota", "Mycolicibacterium canariasense" ]

[ 767, 1 ]

2

[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 21, 8, 6 ]

3

true

Family

Voltage-dependent calcium channel, P/Q-type, alpha-1 A

CACNA1A

5

IPR005449

5,449

Voltage-dependent calcium channel, R-type, alpha-1 subunit

VDCC_R_a1su

Family

1,189

false

Ca2+ ions are unique in that they not only carry charge but they are also the most widely used of diffusible second messengers. Voltage-dependent Ca2+ channels (VDCC) are a family of molecules that allow cells to couple electrical activity to intracellular Ca2+ signalling. The opening and closing of these channels by d...

[ "GO:0005245", "GO:0070588", "GO:0005891" ]

[ "voltage-gated calcium channel activity", "calcium ion transmembrane transport", "voltage-gated calcium channel complex" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PRINTS" ]

[ "PR01633" ]

[ "RVDCCALPHA1" ]

[ 1189 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-112308", "R-HSA-422356", "R-MMU-112308", "R-MMU-422356", "R-RNO-112308", "R-RNO-422356" ]

[ "REACTOME:R-HSA-112308", "REACTOME:R-HSA-422356", "REACTOME:R-MMU-112308", "REACTOME:R-MMU-422356", "REACTOME:R-RNO-112308", "REACTOME:R-RNO-422356" ]

6

[ "7xlq", "7yg5", "8epl", "8epm" ]

4

[ "PUB00007833", "PUB00007834", "PUB00007835", "PUB00036034", "PUB00036040", "PUB00036041" ]

[ "9257934", "11067968", "11698583", "14657414", "11031246", "10774722" ]

[ "Contrasting biophysical and pharmacological properties of T-type and R-type calcium channels.", "Unique properties of R-type calcium currents in neocortical and neostriatal neurons.", "Presynaptic R-type calcium channels contribute to fast excitatory synaptic transmission in the rat hippocampus.", "Internati...

[ 1997, 2000, 2001, 2003, 2000, 2000 ]

6

[ "IPR002077" ]

[]

1

0

1

[ "Gnathostomata" ]

[ 1189 ]

1

[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 7, 5, 9 ]

3

true

Family

Voltage-dependent calcium channel, R-type, alpha-1 subunit

VDCC_R_a1su

2

IPR005450

5,450

Voltage-dependent calcium channel, L-type, alpha-1S subunit

VDCC_L_a1ssu

Family

1,591

false

Ca2+ ions are unique in that they not only carry charge but they are also the most widely used of diffusible second messengers. Voltage-dependent Ca2+ channels (VDCC) are a family of molecules that allow cells to couple electrical activity to intracellular Ca2+ signalling. The opening and closing of these channels by d...

[ "GO:0005245", "GO:0070588", "GO:0005891" ]

[ "voltage-gated calcium channel activity", "calcium ion transmembrane transport", "voltage-gated calcium channel complex" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PRINTS" ]

[ "PR01634" ]

[ "LVDCCALPHA1S" ]

[ 1591 ]

1

[ "REACTOME" ]

[ "R-HSA-419037" ]

[ "REACTOME:R-HSA-419037" ]

1

[ "3jbr", "5gjv", "5gjw", "6byo", "6jp5", "6jp8", "6jpa", "6jpb", "7jpk", "7jpl", "7jpv", "7jpw", "7jpx", "8e56", "8e57", "8e58" ]

16

[ "PUB00007836", "PUB00036034", "PUB00036040", "PUB00036041", "PUB00036043", "PUB00071805" ]

[ "3037387", "14657414", "11031246", "10774722", "12825828", "15336981" ]

[ "Primary structure of the receptor for calcium channel blockers from skeletal muscle.", "International Union of Pharmacology. XL. Compendium of voltage-gated ion channels: calcium channels.", "Structure and regulation of voltage-gated Ca2+ channels.", "Nomenclature of voltage-gated calcium channels.", "1,4-...

[ 1987, 2003, 2000, 2000, 2003, 2004 ]

6

[ "IPR005446" ]

[]

1

0

1

[ "Gnathostomata" ]

[ 1591 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 3, 8, 4, 3 ]

4

true

Family

Voltage-dependent calcium channel, L-type, alpha-1S subunit

VDCC_L_a1ssu

1

IPR005452

5,452

Voltage-dependent calcium channel, L-type, alpha-1D subunit

LVDCC_a1dsu

Family

1,469

false

This entry represents the alpha-1D subunits of the Voltage-dependent calcium channel, L-type (LVDCC), which allow cells to slowly inactivate voltage-gated Ca2+ influx to weak depolarisations [ ]. This property allows them to participate in important physiological functions, such as tonic neurotransmitter release in coc...

[ "GO:0005245", "GO:0070588", "GO:0005891" ]

[ "voltage-gated calcium channel activity", "calcium ion transmembrane transport", "voltage-gated calcium channel complex" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PRINTS" ]

[ "PR01636" ]

[ "LVDCCALPHA1D" ]

[ 1469 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-GGA-422356", "R-HSA-400042", "R-HSA-419037", "R-HSA-422356", "R-HSA-9662360", "R-MMU-422356", "R-RNO-422356" ]

[ "REACTOME:R-GGA-422356", "REACTOME:R-HSA-400042", "REACTOME:R-HSA-419037", "REACTOME:R-HSA-422356", "REACTOME:R-HSA-9662360", "REACTOME:R-MMU-422356", "REACTOME:R-RNO-422356" ]

7

[ "7uhf", "7uhg", "8e59", "8e5a", "8e5b" ]

5

[ "PUB00007839", "PUB00007840", "PUB00007841", "PUB00036034", "PUB00036040", "PUB00036041", "PUB00036043", "PUB00071805", "PUB00100491" ]

[ "11285265", "10639174", "8930286", "14657414", "11031246", "10774722", "12825828", "15336981", "28472301" ]

[ "alpha 1D (Cav1.3) subunits can form l-type Ca2+ channels activating at negative voltages.", "Kinetics of exocytosis and endocytosis at the cochlear inner hair cell afferent synapse of the mouse.", "Dihydropyridine-sensitive, voltage-gated Ca2+ channels contribute to the resting intracellular Ca2+ concentration...

[ 2001, 2000, 1996, 2003, 2000, 2000, 2003, 2004, 2017 ]

9

[ "IPR005446" ]

[]

1

0

1

[ "Euteleostomi" ]

[ 1469 ]

1

[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 10, 7, 15 ]

3

true

Family

Voltage-dependent calcium channel, L-type, alpha-1D subunit

LVDCC_a1dsu

3

IPR005453

5,453

Pollen allergen Lol p2

Allergen_Lolp2

Family

239

false

Grass pollen allergy is a major human health problem throughout the world, perennial ryegrass (Lolium perenne) being one of the more important species causing such allergy. Several proteins from this grass pollen have been characterised and used to study specific serum antibody responses in individuals allergic to poll...

[ "GO:0005576" ]

[ "extracellular region" ]

[ "cellular_component" ]

1

[ "PRINTS" ]

[ "PR01637" ]

[ "LOLP2ALLERGN" ]

[ 239 ]

1

[]

0

[ "1bmw", "1who", "1whp", "2jnz", "2vxq", "3ft1", "3ft9" ]

7

[ "PUB00007842", "PUB00007843", "PUB00007844", "PUB00007845", "PUB00007846", "PUB00007847" ]

[ "1560197", "2715056", "3261461", "2496037", "9130496", "10467147" ]

[ "Human T cell responses to purified pollen allergens of the grass, Lolium perenne. Analysis of relationship between structural homology and T cell recognition.", "Human immune responsiveness to Lolium perenne pollen allergen Lol p III (rye III) is associated with HLA-DR3 and DR5.", "Association of HLA-DR3 with ...

[ 1992, 1989, 1988, 1989, 1997, 1999 ]

6

[]

0

null

[ "Poaceae" ]

[ 239 ]

1

[ "Oryza sativa subsp. japonica" ]

[ 37 ]

1

true

Family

Pollen allergen Lol p2

Allergen_Lolp2

1

IPR005454

5,454

Profilin1/2/3, vertebrate

Profilin1/2/3_vertebrate

Family

2,446

false

This entry represents Profilin1/2/3 (PFN1-3) from vertebrates.

[ "GO:0003779", "GO:0030036" ]

[ "actin binding", "actin cytoskeleton organization" ]

[ "molecular_function", "biological_process" ]

2

[ "PRINTS" ]

[ "PR01639" ]

[ "PROFILINMAML" ]

[ 2446 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-4086400", "R-BTA-5663220", "R-HSA-114608", "R-HSA-376176", "R-HSA-4086400", "R-HSA-5663220", "R-MMU-376176", "R-MMU-4086400", "R-MMU-5663220", "R-RNO-4086400", "R-RNO-5663220" ]

[ "REACTOME:R-BTA-4086400", "REACTOME:R-BTA-5663220", "REACTOME:R-HSA-114608", "REACTOME:R-HSA-376176", "REACTOME:R-HSA-4086400", "REACTOME:R-HSA-5663220", "REACTOME:R-MMU-376176", "REACTOME:R-MMU-4086400", "REACTOME:R-MMU-5663220", "REACTOME:R-RNO-4086400", "REACTOME:R-RNO-5663220" ]

11

[ "1awi", "1cf0", "1cjf", "1d1j", "1fik", "1fil", "1hlu", "1pfl", "1pne", "2btf", "2pav", "2pbd", "2v8c", "2v8f", "2vk3", "3chw", "3u4l", "3ub5", "4x1l", "4x1m", "4x25", "6nas", "6nbe", "6nbw", "7p1h", "8bjh", "8bji", "8bjj", "8br0", "8rty", "9azp" ]

31

[ "PUB00071234", "PUB00071235" ]

[ "19419568", "16542844" ]

[ "Testis-expressed profilins 3 and 4 show distinct functional characteristics and localize in the acroplaxome-manchette complex in spermatids.", "Profilin: emerging concepts and lingering misconceptions." ]

[ 2009, 2006 ]

2

[ "IPR005455" ]

[]

1

0

1

[ "Bilateria" ]

[ 2446 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 5, 14, 10, 13 ]

4

true

Family

Profilin1/2/3, vertebrate

Profilin1/2/3_vertebrate

6

IPR005455

5,455

Profilin, eukaryotic type

PFN_euk

Family

9,302

false

This entry represents the Profilin family, which are small eukaryotic proteins that have different functions. In plants, they are major allergens present in pollens [ ]. The majority of the Profilin family members binds to monomeric actin (G-actin) in a 1:1 ratio thus preventing the polymerisation of actin into filamen...

[ "GO:0003779" ]

[ "actin binding" ]

[ "molecular_function" ]

1

[ "PRINTS", "PRINTS", "PANTHER", "SMART", "CDD" ]

[ "PR00392", "PR01640", "PTHR11604", "SM00392", "cd00148" ]

[ "PROFILIN", "PROFILINPLNT", "", "PROF", "PROF" ]

[ 6076, 4910, 6504, 8906, 7851 ]

5

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-4086400", "R-BTA-5663220", "R-HSA-114608", "R-HSA-376176", "R-HSA-4086400", "R-HSA-5663220", "R-MMU-376176", "R-MMU-4086400", "R-MMU-5663220", "R-RNO-4086400", "R-RNO-5663220" ]

[ "REACTOME:R-BTA-4086400", "REACTOME:R-BTA-5663220", "REACTOME:R-HSA-114608", "REACTOME:R-HSA-376176", "REACTOME:R-HSA-4086400", "REACTOME:R-HSA-5663220", "REACTOME:R-MMU-376176", "REACTOME:R-MMU-4086400", "REACTOME:R-MMU-5663220", "REACTOME:R-RNO-4086400", "REACTOME:R-RNO-5663220" ]

11

[ "1a0k", "1acf", "1awi", "1cf0", "1cjf", "1cqa", "1d1j", "1f2k", "1fik", "1fil", "1g5u", "1hlu", "1k0k", "1pfl", "1pne", "1prq", "1ypr", "2acg", "2btf", "2jkf", "2jkg", "2pav", "2pbd", "2prf", "2v8c", "2v8f", "2vk3", "3chw", "3d9y", "3dav", "3nec", "3nul"...

72

[ "PUB00000725", "PUB00018867", "PUB00063827", "PUB00063828", "PUB00071234", "PUB00071235", "PUB00081657" ]

[ "7945274", "1651167", "11034907", "21458043", "19419568", "16542844", "11137023" ]

[ "Profilin: at the crossroads of signal transduction and the actin cytoskeleton.", "Profilin, a weak CAP for actin and RAS.", "Alternative splicing of the mouse profilin II gene generates functionally different profilin isoforms.", "Profilin: a relevant aeroallergen?", "Testis-expressed profilins 3 and 4 sho...

[ 1994, 1991, 2000, 2011, 2009, 2006, 2000 ]

7

[ "IPR048278" ]

[ "IPR005454", "IPR016814" ]

1

2

0

[ "Bacteria", "Chordopoxvirinae", "Eukaryota" ]

[ 26, 49, 9227 ]

3

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 15, 3, 6, 2, 12, 11, 1, 4, 14, 1, 1, 50 ]

12

true

Family

Profilin, eukaryotic type

PFN_euk

4

IPR005456

5,456

Pre-pro melanin-concentrating hormone

Prepro-melanin_conc_hormone

Family

936

false

Melanin-concentrating hormone (MCH) is a cyclic peptide originally identified in teleost fish [ , ]. In fish, MCH is released from the pituitary and causes lightening of skin pigment cells through pigment aggregation [ ]. In mammals, MCH is predominantly expressed in the hypothalamus, and functions as a neurotransmitte...

[ "GO:0030354", "GO:0007268" ]

[ "melanin-concentrating hormone activity", "chemical synaptic transmission" ]

[ "molecular_function", "biological_process" ]

2

[ "PFAM", "PRINTS", "PANTHER" ]

[ "PF05824", "PR01641", "PTHR12091" ]

[ "Pro-MCH", "PROMCHFAMILY", "" ]

[ 909, 730, 924 ]

3

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-CFA-375276", "R-CFA-416476", "R-CFA-418594", "R-HSA-375276", "R-HSA-416476", "R-HSA-418594", "R-MMU-375276", "R-MMU-416476", "R-MMU-418594", "R-RNO-375276", "R-RNO-416476", "R-RNO-418594" ]

[ "REACTOME:R-CFA-375276", "REACTOME:R-CFA-416476", "REACTOME:R-CFA-418594", "REACTOME:R-HSA-375276", "REACTOME:R-HSA-416476", "REACTOME:R-HSA-418594", "REACTOME:R-MMU-375276", "REACTOME:R-MMU-416476", "REACTOME:R-MMU-418594", "REACTOME:R-RNO-375276", "REACTOME:R-RNO-416476", "REACTOME:R-RNO-418...

12

[ "8wss", "8wst", "8wwk", "8wwl", "8wwm", "8wwn" ]

6

[ "PUB00007848", "PUB00007849", "PUB00007850", "PUB00007851", "PUB00007852" ]

[ "10421367", "10421368", "10996523", "8559281", "9175893" ]

[ "Melanin-concentrating hormone is the cognate ligand for the orphan G-protein-coupled receptor SLC-1.", "Molecular characterization of the melanin-concentrating-hormone receptor.", "Melanin-concentrating hormone receptor: an orphan receptor fits the key.", "Identification, cellular localization and in vitro r...

[ 1999, 1999, 2000, 1995, 1997 ]

5

[]

0

null

[ "Gnathostomata" ]

[ 936 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 5, 2, 3 ]

4

true

Family

Pre-pro melanin-concentrating hormone

Prepro-melanin_conc_hormone

2

IPR005457

5,457

Transient receptor potential channel, canonical 1

TRPC1_channel

Family

1,178

false

Transient receptor potential (TRP) channels can be described as tetramers formed by subunits with six transmembrane domains and containing cation-selective pores, which in several cases show high calcium permeability. The molecular architecture of TRP channels is reminiscent of voltage-gated channels and comprises six ...

[ "GO:0005262", "GO:0070588", "GO:0016020" ]

[ "calcium channel activity", "calcium ion transmembrane transport", "membrane" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PRINTS" ]

[ "PR01642" ]

[ "TRPCHANNEL1" ]

[ 1178 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-3295583", "R-HSA-418890", "R-HSA-5578775", "R-HSA-983695", "R-MMU-3295583", "R-MMU-5578775", "R-MMU-983695", "R-RNO-3295583", "R-RNO-5578775", "R-RNO-983695" ]

[ "REACTOME:R-HSA-3295583", "REACTOME:R-HSA-418890", "REACTOME:R-HSA-5578775", "REACTOME:R-HSA-983695", "REACTOME:R-MMU-3295583", "REACTOME:R-MMU-5578775", "REACTOME:R-MMU-983695", "REACTOME:R-RNO-3295583", "REACTOME:R-RNO-5578775", "REACTOME:R-RNO-983695" ]

10

[ "8wpl", "8wpm", "9khi" ]

3

[ "PUB00054048", "PUB00054049", "PUB00054050", "PUB00054051", "PUB00054052", "PUB00054053" ]

[ "18535090", "20025796", "20861159", "15909153", "12032305", "11864597" ]

[ "TRP channels entering the structural era.", "Structure-functional intimacies of transient receptor potential channels.", "The role of transient receptor potential cation channels in Ca2+ signaling.", "Functional characterization and physiological relevance of the TRPC3/6/7 subfamily of cation channels.", "...

[ 2008, 2009, 2010, 2005, 2002, 2002 ]

6

[ "IPR002153" ]

[]

1

0

1

[ "Vertebrata" ]

[ 1178 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 4, 3, 10 ]

4

true

Family

Transient receptor potential channel, canonical 1

TRPC1_channel

7

IPR005458

5,458

Transient receptor potential channel, canonical 2

TRPC2_channel

Family

607

false

Transient receptor potential (TRP) channels can be described as tetramers formed by subunits with six transmembrane domains and containing cation-selective pores, which in several cases show high calcium permeability. The molecular architecture of TRP channels is reminiscent of voltage-gated channels and comprises six ...

[ "GO:0005262", "GO:0070588", "GO:0016020" ]

[ "calcium channel activity", "calcium ion transmembrane transport", "membrane" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PRINTS" ]

[ "PR01643" ]

[ "TRPCHANNEL2" ]

[ 607 ]

1

[]

0

[]

0

[ "PUB00054048", "PUB00054049", "PUB00054050", "PUB00054051", "PUB00054052", "PUB00054053" ]

[ "18535090", "20025796", "20861159", "15909153", "12032305", "11864597" ]

[ "TRP channels entering the structural era.", "Structure-functional intimacies of transient receptor potential channels.", "The role of transient receptor potential cation channels in Ca2+ signaling.", "Functional characterization and physiological relevance of the TRPC3/6/7 subfamily of cation channels.", "...

[ 2008, 2009, 2010, 2005, 2002, 2002 ]

6

[ "IPR002153" ]

[]

1

0

1

[ "Vertebrata" ]

[ 607 ]

1

[ "Danio rerio", "Mus musculus", "Rattus norvegicus" ]

[ 2, 2, 3 ]

3

true

Family

Transient receptor potential channel, canonical 2

TRPC2_channel

7

IPR005459

5,459

Transient receptor potential channel, canonical 3

TRPC3_channel

Family

996

false

Transient receptor potential (TRP) channels can be described as tetramers formed by subunits with six transmembrane domains and containing cation-selective pores, which in several cases show high calcium permeability. The molecular architecture of TRP channels is reminiscent of voltage-gated channels and comprises six ...

[ "GO:0005262", "GO:0070588", "GO:0016020" ]

[ "calcium channel activity", "calcium ion transmembrane transport", "membrane" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PRINTS" ]

[ "PR01644" ]

[ "TRPCHANNEL3" ]

[ 996 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-114508", "R-HSA-139853", "R-HSA-3295583", "R-HSA-418890", "R-HSA-9022699", "R-MMU-114508", "R-MMU-139853", "R-MMU-3295583", "R-RNO-114508", "R-RNO-139853", "R-RNO-3295583" ]

[ "REACTOME:R-HSA-114508", "REACTOME:R-HSA-139853", "REACTOME:R-HSA-3295583", "REACTOME:R-HSA-418890", "REACTOME:R-HSA-9022699", "REACTOME:R-MMU-114508", "REACTOME:R-MMU-139853", "REACTOME:R-MMU-3295583", "REACTOME:R-RNO-114508", "REACTOME:R-RNO-139853", "REACTOME:R-RNO-3295583" ]

11

[ "5zbg", "6cud", "6d7l", "7dxb", "7dxc", "7dxd", "7dxe", "9kdb", "9kdc", "9kdd", "9kde", "9u5c" ]

12

[ "PUB00007858", "PUB00054048", "PUB00054049", "PUB00054050", "PUB00054051", "PUB00054052", "PUB00054053", "PUB00100466", "PUB00100467" ]

[ "9930701", "18535090", "20025796", "20861159", "15909153", "12032305", "11864597", "32037396", "20095964" ]

[ "Direct activation of human TRPC6 and TRPC3 channels by diacylglycerol.", "TRP channels entering the structural era.", "Structure-functional intimacies of transient receptor potential channels.", "The role of transient receptor potential cation channels in Ca2+ signaling.", "Functional characterization and ...

[ 1999, 2008, 2009, 2010, 2005, 2002, 2002, 2020, 2010 ]

9

[ "IPR002153" ]

[]

1

0

1

[ "Gnathostomata" ]

[ 996 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 1, 6, 5 ]

4

true

Family

Transient receptor potential channel, canonical 3

TRPC3_channel

4

IPR005460

5,460

Transient receptor potential channel, canonical 4

TRPC4_channel

Family

813

false

Transient receptor potential (TRP) channels can be described as tetramers formed by subunits with six transmembrane domains and containing cation-selective pores, which in several cases show high calcium permeability. The molecular architecture of TRP channels is reminiscent of voltage-gated channels and comprises six ...

[ "GO:0005262", "GO:0070588", "GO:0016020" ]

[ "calcium channel activity", "calcium ion transmembrane transport", "membrane" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PRINTS" ]

[ "PR01645" ]

[ "TRPCHANNEL4" ]

[ 813 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-3295583", "R-HSA-3295583", "R-HSA-418890", "R-MMU-3295583", "R-RNO-3295583" ]

[ "REACTOME:R-BTA-3295583", "REACTOME:R-HSA-3295583", "REACTOME:R-HSA-418890", "REACTOME:R-MMU-3295583", "REACTOME:R-RNO-3295583" ]

5

[ "8wpl", "8wpm", "8wpn" ]

3

[ "PUB00054048", "PUB00054049", "PUB00054050", "PUB00054051", "PUB00054052", "PUB00054053", "PUB00054060" ]

[ "18535090", "20025796", "20861159", "15909153", "12032305", "11864597", "12765689" ]

[ "TRP channels entering the structural era.", "Structure-functional intimacies of transient receptor potential channels.", "The role of transient receptor potential cation channels in Ca2+ signaling.", "Functional characterization and physiological relevance of the TRPC3/6/7 subfamily of cation channels.", "...

[ 2008, 2009, 2010, 2005, 2002, 2002, 2003 ]

7

[ "IPR002153" ]

[]

1

0

1

[ "Tetrapoda" ]

[ 813 ]

1

[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 4, 3, 8 ]

3

true

Family

Transient receptor potential channel, canonical 4

TRPC4_channel

5

IPR005461

5,461

Transient receptor potential channel, canonical 5

TRPC5_channel

Family

784

false

Transient receptor potential (TRP) channels can be described as tetramers formed by subunits with six transmembrane domains and containing cation-selective pores, which in several cases show high calcium permeability. The molecular architecture of TRP channels is reminiscent of voltage-gated channels and comprises six ...

[ "GO:0005262", "GO:0070588", "GO:0016020" ]

[ "calcium channel activity", "calcium ion transmembrane transport", "membrane" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PRINTS" ]

[ "PR01646" ]

[ "TRPCHANNEL5" ]

[ 784 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-3295583", "R-HSA-3295583", "R-HSA-418890", "R-MMU-3295583" ]

[ "REACTOME:R-BTA-3295583", "REACTOME:R-HSA-3295583", "REACTOME:R-HSA-418890", "REACTOME:R-MMU-3295583" ]

4

[ "6aei", "7d4p", "7d4q", "7e4t", "7wdb", "7x6c", "7x6i", "8gvw", "8gvx", "9g4y", "9g50", "9gkb", "9gl6", "9khi", "9khj", "9khk", "9m36", "9m4w", "9m5v" ]

19

[ "PUB00054048", "PUB00054049", "PUB00054050", "PUB00054051", "PUB00054052", "PUB00054053", "PUB00054060" ]

[ "18535090", "20025796", "20861159", "15909153", "12032305", "11864597", "12765689" ]

[ "TRP channels entering the structural era.", "Structure-functional intimacies of transient receptor potential channels.", "The role of transient receptor potential cation channels in Ca2+ signaling.", "Functional characterization and physiological relevance of the TRPC3/6/7 subfamily of cation channels.", "...

[ 2008, 2009, 2010, 2005, 2002, 2002, 2003 ]

7

[ "IPR002153" ]

[]

1

0

1

[ "Gnathostomata" ]

[ 784 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 2, 3, 2 ]

4

true

Family

Transient receptor potential channel, canonical 5

TRPC5_channel

4

IPR005462

5,462

Transient receptor potential channel, canonical 6

TRPC6_channel

Family

589

false

Transient receptor potential (TRP) channels can be described as tetramers formed by subunits with six transmembrane domains and containing cation-selective pores, which in several cases show high calcium permeability. The molecular architecture of TRP channels is reminiscent of voltage-gated channels and comprises six ...

[ "GO:0005262", "GO:0070588", "GO:0016020" ]

[ "calcium channel activity", "calcium ion transmembrane transport", "membrane" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PRINTS" ]

[ "PR01647" ]

[ "TRPCHANNEL6" ]

[ 589 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-114508", "R-BTA-139853", "R-BTA-3295583", "R-HSA-114508", "R-HSA-139853", "R-HSA-3295583", "R-HSA-418890", "R-MMU-114508", "R-MMU-139853", "R-MMU-3295583" ]

[ "REACTOME:R-BTA-114508", "REACTOME:R-BTA-139853", "REACTOME:R-BTA-3295583", "REACTOME:R-HSA-114508", "REACTOME:R-HSA-139853", "REACTOME:R-HSA-3295583", "REACTOME:R-HSA-418890", "REACTOME:R-MMU-114508", "REACTOME:R-MMU-139853", "REACTOME:R-MMU-3295583" ]

10

[ "5yx9", "6cv9", "6uz8", "6uza", "7a6u", "7dxf", "7dxg" ]

7

[ "PUB00054048", "PUB00054049", "PUB00054050", "PUB00054051", "PUB00054052", "PUB00054053" ]

[ "18535090", "20025796", "20861159", "15909153", "12032305", "11864597" ]

[ "TRP channels entering the structural era.", "Structure-functional intimacies of transient receptor potential channels.", "The role of transient receptor potential cation channels in Ca2+ signaling.", "Functional characterization and physiological relevance of the TRPC3/6/7 subfamily of cation channels.", "...

[ 2008, 2009, 2010, 2005, 2002, 2002 ]

6

[ "IPR002153" ]

[]

1

0

1

[ "Gnathostomata" ]

[ 589 ]

1

[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 3, 2, 8 ]

3

true

Family

Transient receptor potential channel, canonical 6

TRPC6_channel

2

IPR005464

5,464

Psychosine receptor

Psych_rcpt

Family

596

false

G protein-coupled receptors (GPCRs) constitute a vast protein family that encompasses a wide range of functions, including various autocrine, paracrine and endocrine processes. They show considerable diversity at the sequence level, on the basis of which they can be separated into distinct groups [ ]. The term clan can...

[ "GO:0004930", "GO:0016020" ]

[ "G protein-coupled receptor activity", "membrane" ]

[ "molecular_function", "cellular_component" ]

2

[ "PRINTS" ]

[ "PR01649" ]

[ "PSYCHOSINER" ]

[ 596 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-373076", "R-HSA-416476", "R-MMU-373076", "R-MMU-416476" ]

[ "REACTOME:R-HSA-373076", "REACTOME:R-HSA-416476", "REACTOME:R-MMU-373076", "REACTOME:R-MMU-416476" ]

4

[ "9bhl", "9jft" ]

2

[ "PUB00000131", "PUB00002477", "PUB00004960", "PUB00004961", "PUB00007863", "PUB00053635", "PUB00063577", "PUB00063578", "PUB00063579", "PUB00063580", "PUB00063816" ]

[ "2111655", "2830256", "8386361", "8170923", "11309421", "12679517", "8081729", "15914470", "18948278", "16753280", "23020293" ]

[ "G proteins in signal transduction.", "G protein involvement in receptor-effector coupling.", "Design of a discriminating fingerprint for G-protein-coupled receptors.", "Fingerprinting G-protein-coupled receptors.", "Identification of a molecular target of psychosine and its role in globoid cell formation."...

[ 1990, 1988, 1993, 1994, 2001, 2003, 1994, 2005, 2009, 2006, 2013 ]

11

[ "IPR000276" ]

[]

1

0

1

[ "Gnathostomata" ]

[ 596 ]

1

[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 3, 4, 2 ]

3

true

Family

Psychosine receptor

Psych_rcpt

5

IPR005466

5,466

P2Y14 purinoceptor

P2Y14_rcpt

Family

1,175

false

There are three distinct families of extracellular receptors for purine and pyrimidine nucleotides [ ], known as P1, P2X and P2Y purinoceptors [ ]. These receptors induce a wide variety of biological effects and are involved in many different cellular functions [ , , ]. P2X receptors are ligand-gated ion channels, wher...

[ "GO:0045028", "GO:0007186", "GO:0016020" ]

[ "G protein-coupled purinergic nucleotide receptor activity", "G protein-coupled receptor signaling pathway", "membrane" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PRINTS" ]

[ "PR01655" ]

[ "UDPGLUCOSER" ]

[ 1175 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-417957", "R-BTA-418594", "R-HSA-417957", "R-HSA-418594", "R-MMU-417957", "R-MMU-418594", "R-RNO-417957", "R-RNO-418594" ]

[ "REACTOME:R-BTA-417957", "REACTOME:R-BTA-418594", "REACTOME:R-HSA-417957", "REACTOME:R-HSA-418594", "REACTOME:R-MMU-417957", "REACTOME:R-MMU-418594", "REACTOME:R-RNO-417957", "REACTOME:R-RNO-418594" ]

8

[ "9j05", "9j0b", "9j0f", "9j0i" ]

4

[ "PUB00007054", "PUB00007865", "PUB00028347", "PUB00033968", "PUB00066193", "PUB00066194", "PUB00066195", "PUB00066196", "PUB00066197", "PUB00066198", "PUB00066203", "PUB00066204", "PUB00066205", "PUB00066206", "PUB00066207", "PUB00066208", "PUB00066209", "PUB00066210", "PUB000662...

[ "12270951", "10753868", "8872457", "11111826", "10629443", "20471713", "11099464", "19921464", "11734617", "16257449", "9364468", "7724657", "16968944", "8508924", "19386608", "8921391", "8702478", "12724320", "18404483", "9755289", "11794691", "16914897", "16934527", "...

[ "Molecular physiology of P2X receptors.", "A G protein-coupled receptor for UDP-glucose.", "Modelling the P2Y purinoceptor using rhodopsin as template.", "Molecular pharmacology of P2Y-receptors.", "Renal vascular reactivity to P(2)-purinoceptor activation in spontaneously hypertensive rats.", "Purinergic...

[ 2002, 2000, 1995, 2000, 2000, 2011, 2000, 2010, 2001, 2006, 1997, 1994, 2006, 1993, 2009, 1996, 1996, 2003, 2006, 1998, 2001, 2006, 2006, 2000, 2005, 2005, 2003, 2003, 2001, 2003 ]

30

[ "IPR000276" ]

[]

1

0

1

[ "Gnathostomata" ]

[ 1175 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 3, 4, 3 ]

4

true

Family

P2Y14 purinoceptor

P2Y14_rcpt

7

IPR005467

5,467

Histidine kinase domain

His_kinase_dom

Domain

903,074

false

The entry represents the histidine kinase core. Most prokaryotic signal-transduction systems and a few eukaryotic pathways use phosphotransfer schemes involving two conserved components, a histidine protein kinase (HK) and a response regulator protein (RR). The HK, which is regulated by environmental stimuli, autophosp...

[]

0

[ "PROFILE" ]

[ "PS50109" ]

[ "HIS_KIN" ]

[ 903074 ]

1

[ "EC", "PROSITEDOC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", ...

[ "2.7.13.3", "PDOC50109", "R-BTA-70895", "R-CEL-204174", "R-CEL-5362517", "R-CEL-9837999", "R-DME-204174", "R-DME-5362517", "R-DME-9837999", "R-HSA-204174", "R-HSA-5362517", "R-HSA-70895", "R-HSA-9837999", "R-HSA-9841922", "R-HSA-9912481", "R-MMU-204174", "R-MMU-5362517", "R-MMU-708...

[ "EC:2.7.13.3", "PROSITEDOC:PDOC50109", "REACTOME:R-BTA-70895", "REACTOME:R-CEL-204174", "REACTOME:R-CEL-5362517", "REACTOME:R-CEL-9837999", "REACTOME:R-DME-204174", "REACTOME:R-DME-5362517", "REACTOME:R-DME-9837999", "REACTOME:R-HSA-204174", "REACTOME:R-HSA-5362517", "REACTOME:R-HSA-70895", ...

26

[ "1b3q", "1bxd", "1gjv", "1gkx", "1gkz", "1i58", "1i59", "1i5a", "1i5b", "1i5c", "1i5d", "1id0", "1jm6", "1r62", "1y8n", "1y8o", "1y8p", "1ys3", "1ysr", "2btz", "2bu2", "2bu5", "2bu6", "2bu7", "2bu8", "2c2a", "2ch4", "2e0a", "2pnr", "2q8f", "2q8g", "2q8h"...

223

[ "PUB00007866", "PUB00007867", "PUB00011096" ]

[ "11406410", "11369279", "10966457" ]

[ "Histidine kinases and response regulator proteins in two-component signaling systems.", "The molecular puzzle of two-component signaling cascades.", "Two-component signal transduction." ]

[ 2001, 2001, 2000 ]

3

[]

[ "IPR043836" ]

0

1

0

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "plasmids", "unclassified sequences" ]

[ 15587, 830803, 47652, 54, 2, 8976 ]

6

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus",...

[ 197, 1, 8, 4, 28, 14, 12, 13, 68, 18, 2, 4, 167 ]

13

true

Domain

Histidine kinase domain

His_kinase_dom

9

IPR005468

5,468

Avidin/streptavidin

Avidin/str

Family

3,112

false

This entry includes avidin and streptavidin, and their homologs such as afifavidin [ ], hoefavidin [ ] and fibropellin [ ]. Avidin [ ] is a minor constituent of egg white in several groups of oviparous vertebrates. Avidin, which was discovered in the 1920's, takes its name from the avidity with which it binds biotin. T...

[ "GO:0009374" ]

[ "biotin binding" ]

[ "molecular_function" ]

1

[ "PFAM", "PROFILE" ]

[ "PF01382", "PS51326" ]

[ "Avidin", "AVIDIN_2" ]

[ 3004, 2909 ]

2

[ "PROSITEDOC" ]

[ "PDOC00499" ]

[ "PROSITEDOC:PDOC00499" ]

1

[ "1avd", "1ave", "1df8", "1hqq", "1hxl", "1hxz", "1hy2", "1i9h", "1ij8", "1kff", "1kl3", "1kl4", "1kl5", "1lcv", "1lcw", "1lcz", "1ldo", "1ldq", "1lel", "1luq", "1mep", "1mk5", "1mm9", "1moy", "1n43", "1n4j", "1n7y", "1n9m", "1n9y", "1nbx", "1nc9", "1ndj"...

399

[ "PUB00001099", "PUB00001496", "PUB00003308", "PUB00003567", "PUB00004675", "PUB00151105", "PUB00151106", "PUB00151107" ]

[ "8500658", "2784773", "8515446", "2388586", "2928324", "2060714", "26126731", "30369031" ]

[ "The SpEGF III gene encodes a member of the fibropellins: EGF repeat-containing proteins that form the apical lamina of the sea urchin embryo.", "Avidin-like domain in an epidermal growth factor homolog from a sea urchin.", "Three-dimensional structure of the tetragonal crystal form of egg-white avidin in its f...

[ 1993, 1989, 1993, 1990, 1989, 1991, 2015, 2018 ]

8

[]

[ "IPR005469" ]

0

1

0

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "metagenomes" ]

[ 2, 537, 2566, 4, 3 ]

5

[ "Danio rerio" ]

[ 2 ]

1

true

Family

Avidin/streptavidin

Avidin/str

7

IPR005469

5,469

Avidin

Family

2,228

false

Avidin [ ] is a minor constituent of egg white in several groups of oviparous vertebrates. Avidin, which was discovered in the 1920's, takes its name from the avidity with which it binds biotin. These two molecules bind so strongly that is extremely difficult to separate them. Streptavidin is a protein produced by Stre...

[ "GO:0009374" ]

[ "biotin binding" ]

[ "molecular_function" ]

1

[ "PRINTS" ]

[ "PR00709" ]

[ "AVIDIN" ]

[ 2228 ]

1

[]

0

[ "1avd", "1ave", "1df8", "1hqq", "1hxl", "1hxz", "1hy2", "1i9h", "1ij8", "1kff", "1kl3", "1kl4", "1kl5", "1lcv", "1lcw", "1lcz", "1ldo", "1ldq", "1lel", "1luq", "1mep", "1mk5", "1mm9", "1moy", "1n43", "1n4j", "1n7y", "1n9m", "1n9y", "1nbx", "1nc9", "1ndj"...

364

[ "PUB00001099", "PUB00001496", "PUB00003308", "PUB00003567", "PUB00004675" ]

[ "8500658", "2784773", "8515446", "2388586", "2928324" ]

[ "The SpEGF III gene encodes a member of the fibropellins: EGF repeat-containing proteins that form the apical lamina of the sea urchin embryo.", "Avidin-like domain in an epidermal growth factor homolog from a sea urchin.", "Three-dimensional structure of the tetragonal crystal form of egg-white avidin in its f...

[ 1993, 1989, 1993, 1990, 1989 ]

5

[ "IPR005468" ]

[]

1

0

1

[ "Bacteria", "Eukaryota", "Nitrosopumilus ureiphilus", "Pithoviruses", "metagenomes" ]

[ 130, 2093, 1, 2, 2 ]

5

[ "Danio rerio" ]

[ 2 ]

1

true

Family

Avidin

8

IPR005471

5,471

Transcription regulator IclR, N-terminal

Tscrpt_reg_IclR_N

Domain

116,895

false

null

[ "GO:0003677", "GO:0006355" ]

[ "DNA binding", "regulation of DNA-templated transcription" ]

[ "molecular_function", "biological_process" ]

2

[ "PFAM", "PROFILE", "SMART" ]

[ "PF09339", "PS51077", "SM00346" ]

[ "HTH_IclR", "HTH_ICLR", "HTH_ICLR" ]

[ 115106, 105822, 104319 ]

3

[ "PROSITEDOC" ]

[ "PDOC00807" ]

[ "PROSITEDOC:PDOC00807" ]

1

[ "1mkm", "2g7u", "2ia2", "2o0y", "2xrn", "2xro", "3mq0", "3r4k", "5h1a", "5tjj", "5w1e", "5whm", "5y6i", "7cuo", "7dqb", "8eju", "8ejv", "9e6a" ]

18

[ "PUB00003813" ]

[ "1840643" ]

[ "Characterization of kdgR, a gene of Erwinia chrysanthemi that regulates pectin degradation." ]

[ 1991 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Sym plasmid", "Viruses", "unclassified sequences" ]

[ 3574, 112367, 181, 2, 37, 734 ]

6

[ "Escherichia coli (strain K12)" ]

[ 8 ]

1

true

Domain

Transcription regulator IclR, N-terminal

Tscrpt_reg_IclR_N

6

IPR005474

5,474

Transketolase, N-terminal

Transketolase_N

Domain

71,437

false

This entry represents the N-terminal domain of a group of transketolase proteins widespread among all cellular organisms. Transketolase (TK) catalyses the reversible transfer of a two-carbon ketol unit from xylulose 5-phosphate to an aldose receptor, such as ribose 5-phosphate, to form sedoheptulose 7-phosphate and gly...

[]

0

[ "PFAM", "CDD" ]

[ "PF00456", "cd02012" ]

[ "Transketolase_N", "TPP_TK" ]

[ 71435, 49451 ]

2

[ "EC", "METACYC", "METACYC", "METACYC", "METACYC", "PROSITEDOC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "2.2.1.1", "PWY-1861", "PWY-5723", "PWY-6901", "PWY-8178", "PDOC00635", "R-HSA-163754", "R-HSA-71336", "R-HSA-9818028", "R-MMU-163754", "R-MMU-71336", "R-RNO-163754", "R-RNO-71336" ]

[ "EC:2.2.1.1", "METACYC:PWY-1861", "METACYC:PWY-5723", "METACYC:PWY-6901", "METACYC:PWY-8178", "PROSITEDOC:PDOC00635", "REACTOME:R-HSA-163754", "REACTOME:R-HSA-71336", "REACTOME:R-HSA-9818028", "REACTOME:R-MMU-163754", "REACTOME:R-MMU-71336", "REACTOME:R-RNO-163754", "REACTOME:R-RNO-71336" ]

13

[ "1ay0", "1gpu", "1itz", "1l8a", "1ngs", "1qgd", "1r9j", "1rp7", "1tka", "1tkb", "1tkc", "1trk", "2e6k", "2g25", "2g28", "2g67", "2iea", "2qta", "2qtc", "2r5n", "2r8o", "2r8p", "3hyl", "3kom", "3l84", "3lpl", "3lq2", "3lq4", "3m34", "3m49", "3m6l", "3m7i"...

96

[ "PUB00000209", "PUB00000362", "PUB00001222", "PUB00004906" ]

[ "1567394", "1737042", "1628611", "9371765" ]

[ "Nucleotide and predicted amino acid sequence of a cDNA clone encoding part of human transketolase.", "DNA sequence of the yeast transketolase gene.", "Three-dimensional structure of transketolase, a thiamine diphosphate dependent enzyme, at 2.5 A resolution.", "Identification of a thiamin-dependent synthase ...

[ 1992, 1992, 1992, 1997 ]

4

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Megaviricetes", "unclassified sequences" ]

[ 340, 59819, 9926, 3, 1349 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus",...

[ 8, 1, 3, 4, 3, 22, 6, 1, 8, 14, 2, 1, 13 ]

13

true

Domain

Transketolase, N-terminal

Transketolase_N

3

IPR005475

5,475

Transketolase-like, pyrimidine-binding domain

Transketolase-like_Pyr-bd

Domain

167,485

false

This entry represents the pyrimidine-binding domain of a group of transketolase proteins widespread among all cellular organisms. Transketolase (TK) catalyses the reversible transfer of a two-carbon ketol unit from xylulose 5-phosphate to an aldose receptor, such as ribose 5-phosphate, to form sedoheptulose 7-phosphate...

[]

0

[ "PFAM", "SMART" ]

[ "PF02779", "SM00861" ]

[ "Transket_pyr", "Transket_pyr" ]

[ 164837, 164934 ]

2

[ "EC", "EC", "GP", "METACYC", "METACYC", "METACYC", "PROSITEDOC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", ...

[ "2.2.1", "2.2.1.7", "GenProp1408", "PWY-6891", "PWY-6892", "PWY-7560", "PDOC00635", "R-BTA-204174", "R-BTA-5362517", "R-BTA-6783984", "R-BTA-70895", "R-BTA-9837999", "R-BTA-9853506", "R-BTA-9859138", "R-BTA-9861559", "R-CEL-204174", "R-CEL-5362517", "R-CEL-6783984", "R-CEL-983799...

[ "EC:2.2.1", "EC:2.2.1.7", "GP:GenProp1408", "METACYC:PWY-6891", "METACYC:PWY-6892", "METACYC:PWY-7560", "PROSITEDOC:PDOC00635", "REACTOME:R-BTA-204174", "REACTOME:R-BTA-5362517", "REACTOME:R-BTA-6783984", "REACTOME:R-BTA-70895", "REACTOME:R-BTA-9837999", "REACTOME:R-BTA-9853506", "REACTOME...

83

[ "1ay0", "1dtw", "1gpu", "1ik6", "1itz", "1ngs", "1ni4", "1ols", "1olu", "1olx", "1qgd", "1qs0", "1r9j", "1tka", "1tkb", "1tkc", "1trk", "1u5b", "1um9", "1umb", "1umc", "1umd", "1v11", "1v16", "1v1m", "1v1r", "1w85", "1w88", "1wci", "1x7w", "1x7x", "1x7y"...

191

[ "PUB00000209", "PUB00000362", "PUB00001222", "PUB00004906" ]

[ "1567394", "1737042", "1628611", "9371765" ]

[ "Nucleotide and predicted amino acid sequence of a cDNA clone encoding part of human transketolase.", "DNA sequence of the yeast transketolase gene.", "Three-dimensional structure of transketolase, a thiamine diphosphate dependent enzyme, at 2.5 A resolution.", "Identification of a thiamin-dependent synthase ...

[ 1992, 1992, 1992, 1997 ]

4

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 1157, 127701, 36044, 8, 2575 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus",...

[ 62, 7, 22, 22, 4, 43, 12, 4, 35, 36, 4, 3, 113 ]

13

true

Domain

Transketolase-like, pyrimidine-binding domain

Transketolase-like_Pyr-bd

8

IPR005478

5,478

Transketolase, bacterial-like

Transketolase_bac-like

Family

29,433

false

Transketolase ( ) (TK) catalyzes the reversible transfer of a two-carbon ketol unit from xylulose 5-phosphate to an aldose receptor, such as ribose 5-phosphate, to form sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate. This enzyme, together with transaldolase, provides a link between the glycolytic and pentose-...

[ "GO:0004802" ]

[ "transketolase activity" ]

[ "molecular_function" ]

1

[ "NCBIFAM" ]

[ "TIGR00232" ]

[ "tktlase_bact" ]

[ 29433 ]

1

[ "EC", "GP", "GP", "METACYC", "METACYC", "METACYC", "METACYC" ]

[ "2.2.1.1", "GenProp0120", "GenProp1294", "PWY-1861", "PWY-5723", "PWY-6901", "PWY-8178" ]

[ "EC:2.2.1.1", "GP:GenProp0120", "GP:GenProp1294", "METACYC:PWY-1861", "METACYC:PWY-5723", "METACYC:PWY-6901", "METACYC:PWY-8178" ]

7

[ "1ay0", "1gpu", "1itz", "1ngs", "1qgd", "1r9j", "1tka", "1tkb", "1tkc", "1trk", "2e6k", "2r5n", "2r8o", "2r8p", "3hyl", "3kom", "3l84", "3m34", "3m49", "3m6l", "3m7i", "3rim", "3uk1", "3upt", "4c7v", "4c7x", "4xeu", "5hgx", "5hht", "5hje", "5hyv", "5i4i"...

70

[]

0

[ "IPR033247" ]

[]

1

0

1

[ "Bacteria", "Eukaryota", "unclassified sequences", "uncultured marine thaumarchaeote KM3_54_F04" ]

[ 25193, 3875, 364, 1 ]

4

[ "Arabidopsis thaliana", "Escherichia coli (strain K12)", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)", "Zea mays" ]

[ 8, 2, 1, 7, 2, 1, 8 ]

7

true

Family

Transketolase, bacterial-like

Transketolase_bac-like

8

IPR005479

5,479

Carbamoyl phosphate synthase, ATP-binding domain

CPAse_ATP-bd

Domain

149,295

false

This entry represents the ATP-binding domain found in the large subunit of carbamoyl phosphate synthase, as well as in other proteins, including acetyl-CoA carboxylases and pyruvate carboxylases. Carbamoyl phosphate synthase (CPSase) is a heterodimeric enzyme composed of a small and a large subunit (with the exception ...

[ "GO:0005524" ]

[ "ATP binding" ]

[ "molecular_function" ]

1

[ "PFAM", "PROSITE", "PROSITE" ]

[ "PF02786", "PS00866", "PS00867" ]

[ "CPSase_L_D2", "CPSASE_1", "CPSASE_2" ]

[ 146450, 97304, 132895 ]

3

[ "EC", "EC", "EC", "GP", "GP", "GP", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "PROSITEDOC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACT...

[ "6.3.4", "6.3.4.16", "6.3.5.5", "GenProp1439", "GenProp1629", "GenProp1673", "PWY-4984", "PWY-5154", "PWY-5686", "PWY-7400", "PWY-7790", "PWY-7791", "PDOC00676", "R-BTA-196780", "R-BTA-70263", "R-BTA-70268", "R-CEL-196780", "R-CEL-500753", "R-CEL-70263", "R-CEL-70268", "R-CEL...

[ "EC:6.3.4", "EC:6.3.4.16", "EC:6.3.5.5", "GP:GenProp1439", "GP:GenProp1629", "GP:GenProp1673", "METACYC:PWY-4984", "METACYC:PWY-5154", "METACYC:PWY-5686", "METACYC:PWY-7400", "METACYC:PWY-7790", "METACYC:PWY-7791", "PROSITEDOC:PDOC00676", "REACTOME:R-BTA-196780", "REACTOME:R-BTA-70263", ...

73

[ "1a9x", "1bnc", "1bxr", "1c30", "1c3o", "1ce8", "1cs0", "1dv1", "1dv2", "1jdb", "1kee", "1m6v", "1t36", "1ulz", "1w93", "1w96", "2c00", "2cqy", "2dzd", "2gps", "2gpw", "2hjw", "2j9g", "2qf7", "2v58", "2v59", "2v5a", "2vpq", "2vqd", "2vr1", "2w6m", "2w6n"...

163

[ "PUB00006448", "PUB00007868", "PUB00042596", "PUB00042597", "PUB00042598", "PUB00042599", "PUB00042600", "PUB00042601", "PUB00042602" ]

[ "10387030", "10089390", "17397987", "11212301", "8916922", "12379099", "7907330", "17451989", "7932737" ]

[ "The amidotransferase family of enzymes: molecular machines for the production and delivery of ammonia.", "The structure of carbamoyl phosphate synthetase determined to 2.1 A resolution.", "cyclicAMP and glucocorticoid responsiveness of the rat carbamoylphosphate synthetase gene requires the interplay of upstre...

[ 1999, 1999, 2007, 1999, 1996, 2002, 1994, 2007, 1994 ]

9

[ "IPR011761" ]

[ "IPR005483" ]

1

0

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 1959, 97557, 47877, 7, 1895 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus",...

[ 38, 9, 62, 10, 2, 35, 25, 5, 8, 51, 7, 4, 87 ]

13

true

Domain

Carbamoyl phosphate synthase, ATP-binding domain

CPAse_ATP-bd

8

IPR005480

5,480

Carbamoyl-phosphate synthetase, large subunit oligomerisation domain

CPSase_lsu_oligo

Domain

52,341

false

This entry represents the oligomerisation domain found in the large subunit of carbamoyl phosphate synthases as well as in certain other carboxy phosphate domain-containing enzymes. This domain forms a primarily α-helical fold [ ].

[]

0

[ "PFAM", "SMART" ]

[ "PF02787", "SM01096" ]

[ "CPSase_L_D3", "CPSase_L_D3" ]

[ 51146, 52274 ]

2

[ "EC", "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "6.3.4.16", "6.3.5.5", "PWY-4984", "PWY-5154", "PWY-5686", "PWY-7400", "PWY-7790", "PWY-7791", "R-CEL-500753", "R-DDI-500753", "R-DME-500753", "R-HSA-500753", "R-HSA-70635", "R-MMU-500753", "R-MMU-70635", "R-RNO-70635", "R-SCE-500753", "R-SCE-70635", "R-SPO-500753", "R-SPO-7063...

[ "EC:6.3.4.16", "EC:6.3.5.5", "METACYC:PWY-4984", "METACYC:PWY-5154", "METACYC:PWY-5686", "METACYC:PWY-7400", "METACYC:PWY-7790", "METACYC:PWY-7791", "REACTOME:R-CEL-500753", "REACTOME:R-DDI-500753", "REACTOME:R-DME-500753", "REACTOME:R-HSA-500753", "REACTOME:R-HSA-70635", "REACTOME:R-MMU-5...

20

[ "1a9x", "1bxr", "1c30", "1c3o", "1ce8", "1cs0", "1jdb", "1kee", "1m6v", "1t36", "5dot", "5dou", "6uel", "6w2j" ]

14

[ "PUB00007868" ]

[ "10089390" ]

[ "The structure of carbamoyl phosphate synthetase determined to 2.1 A resolution." ]

[ 1999 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 862, 26707, 24177, 2, 593 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus",...

[ 5, 1, 7, 3, 1, 11, 7, 2, 1, 12, 2, 2, 7 ]

13

true

Domain

Carbamoyl-phosphate synthetase, large subunit oligomerisation domain

CPSase_lsu_oligo

7

IPR005481

5,481

Biotin carboxylase-like, N-terminal domain

BC-like_N

Domain

88,708

false

This domain is structurally related to the PreATP-grasp domain. It is found at the N terminus of biotin carboxylase enzymes [ , , ], and propionyl-CoA carboxylase A chain [ ].

[]

0

[ "PFAM" ]

[ "PF00289" ]

[ "Biotin_carb_N" ]

[ 88708 ]

1

[ "EC", "GP", "GP", "GP", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REA...

[ "6.4.1", "GenProp1439", "GenProp1629", "GenProp1673", "R-BTA-196780", "R-BTA-70263", "R-BTA-70268", "R-CEL-196780", "R-CEL-70263", "R-CEL-70268", "R-CEL-71032", "R-DDI-196780", "R-DDI-200425", "R-DDI-70895", "R-DDI-75105", "R-HSA-163765", "R-HSA-196780", "R-HSA-200425", "R-HSA-24...

[ "EC:6.4.1", "GP:GenProp1439", "GP:GenProp1629", "GP:GenProp1673", "REACTOME:R-BTA-196780", "REACTOME:R-BTA-70263", "REACTOME:R-BTA-70268", "REACTOME:R-CEL-196780", "REACTOME:R-CEL-70263", "REACTOME:R-CEL-70268", "REACTOME:R-CEL-71032", "REACTOME:R-DDI-196780", "REACTOME:R-DDI-200425", "REA...

52

[ "1bnc", "1dv1", "1dv2", "1ulz", "1w93", "1w96", "2c00", "2dzd", "2gps", "2gpw", "2hjw", "2j9g", "2qf7", "2v58", "2v59", "2v5a", "2vpq", "2vqd", "2vr1", "2w6m", "2w6n", "2w6o", "2w6p", "2w6q", "2w6z", "2w70", "2w71", "2yl2", "3bg5", "3g8c", "3g8d", "3gid"...

145

[ "PUB00000390", "PUB00047140", "PUB00078719", "PUB00078720" ]

[ "7915138", "18725455", "20443544", "25383525" ]

[ "Three-dimensional structure of the biotin carboxylase subunit of acetyl-CoA carboxylase.", "Structural evidence for substrate-induced synergism and half-sites reactivity in biotin carboxylase.", "Structural impact of human and Escherichia coli biotin carboxyl carrier proteins on biotin attachment.", "Structu...

[ 1994, 2008, 2010, 2015 ]

4

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 866, 64186, 22759, 897 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus",...

[ 23, 8, 54, 8, 1, 26, 21, 3, 4, 39, 5, 2, 58 ]

13

true

Domain

Biotin carboxylase-like, N-terminal domain

BC-like_N

1

IPR005482

5,482

Biotin carboxylase, C-terminal

Biotin_COase_C

Domain

89,377

false

Acetyl-CoA carboxylase is found in all animals, plants, and bacteria and catalyzes the first committed step in fatty acid synthesis. It is a multicomponent enzyme containing a biotin carboxylase activity, a biotin carboxyl carrier protein, and a carboxyltransferase functionality. The "B-domain" extends from the main bo...

[]

0

[ "PFAM", "SMART" ]

[ "PF02785", "SM00878" ]

[ "Biotin_carb_C", "Biotin_carb_C" ]

[ 88931, 88766 ]

2

[ "EC", "GP", "GP", "GP", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REA...

[ "6.4.1", "GenProp1439", "GenProp1629", "GenProp1673", "R-BTA-196780", "R-BTA-70263", "R-BTA-70268", "R-CEL-196780", "R-CEL-70263", "R-CEL-70268", "R-CEL-71032", "R-DDI-196780", "R-DDI-200425", "R-DDI-70895", "R-DDI-75105", "R-HSA-163765", "R-HSA-196780", "R-HSA-200425", "R-HSA-24...

[ "EC:6.4.1", "GP:GenProp1439", "GP:GenProp1629", "GP:GenProp1673", "REACTOME:R-BTA-196780", "REACTOME:R-BTA-70263", "REACTOME:R-BTA-70268", "REACTOME:R-CEL-196780", "REACTOME:R-CEL-70263", "REACTOME:R-CEL-70268", "REACTOME:R-CEL-71032", "REACTOME:R-DDI-196780", "REACTOME:R-DDI-200425", "REA...

52

[ "1bnc", "1dv1", "1dv2", "1ulz", "1w93", "1w96", "2c00", "2dzd", "2gps", "2gpw", "2hjw", "2j9g", "2qf7", "2v58", "2v59", "2v5a", "2vpq", "2vqd", "2vr1", "2w6m", "2w6n", "2w6o", "2w6p", "2w6q", "2w6z", "2w70", "2w71", "2yl2", "3bg5", "3g8c", "3g8d", "3gid"...

145

[ "PUB00000390" ]

[ "7915138" ]

[ "Three-dimensional structure of the biotin carboxylase subunit of acetyl-CoA carboxylase." ]

[ 1994 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 865, 63999, 23639, 874 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus",...

[ 21, 8, 54, 8, 1, 20, 15, 3, 4, 38, 5, 2, 83 ]

13

true

Domain

Biotin carboxylase, C-terminal

Biotin_COase_C

7

IPR005483

5,483

Carbamoyl phosphate synthase, CPSase domain

CPSase_dom

Domain

51,305

false

This entry represents the CPSase domain of the large subunit of carbamoyl phosphate synthase. Carbamoyl phosphate synthase (CPSase) is a heterodimeric enzyme composed of a small and a large subunit (with the exception of CPSase III, see below). CPSase catalyses the synthesis of carbamoyl phosphate from biocarbonate, AT...

[]

0

[ "PRINTS" ]

[ "PR00098" ]

[ "CPSASE" ]

[ 51305 ]

1

[ "EC", "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "6.3.4.16", "6.3.5.5", "PWY-4984", "PWY-5154", "PWY-5686", "PWY-7400", "PWY-7790", "PWY-7791", "R-CEL-500753", "R-DDI-500753", "R-DME-500753", "R-HSA-500753", "R-HSA-70635", "R-MMU-500753", "R-MMU-70635", "R-RNO-70635", "R-SCE-500753", "R-SCE-70635", "R-SPO-500753", "R-SPO-7063...

[ "EC:6.3.4.16", "EC:6.3.5.5", "METACYC:PWY-4984", "METACYC:PWY-5154", "METACYC:PWY-5686", "METACYC:PWY-7400", "METACYC:PWY-7790", "METACYC:PWY-7791", "REACTOME:R-CEL-500753", "REACTOME:R-DDI-500753", "REACTOME:R-DME-500753", "REACTOME:R-HSA-500753", "REACTOME:R-HSA-70635", "REACTOME:R-MMU-5...

20

[ "1a9x", "1bxr", "1c30", "1c3o", "1ce8", "1cs0", "1jdb", "1kee", "1m6v", "1t36", "5dot", "5dou", "6uel", "6w2j" ]

14

[ "PUB00006448", "PUB00007868", "PUB00042596", "PUB00042597", "PUB00042598", "PUB00042599", "PUB00042600", "PUB00042601", "PUB00042602" ]

[ "10387030", "10089390", "17397987", "11212301", "8916922", "12379099", "7907330", "17451989", "7932737" ]

[ "The amidotransferase family of enzymes: molecular machines for the production and delivery of ammonia.", "The structure of carbamoyl phosphate synthetase determined to 2.1 A resolution.", "cyclicAMP and glucocorticoid responsiveness of the rat carbamoylphosphate synthetase gene requires the interplay of upstre...

[ 1999, 1999, 2007, 1999, 1996, 2002, 1994, 2007, 1994 ]

9

[ "IPR005479" ]

[]

1

0

1

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 892, 27347, 22192, 3, 871 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus",...

[ 5, 1, 7, 2, 1, 13, 8, 2, 2, 12, 2, 2, 7 ]

13

true

Domain

Carbamoyl phosphate synthase, CPSase domain

CPSase_dom

1

IPR005484

5,484

Large ribosomal subunit protein uL18, bacterial/plantae/animalia

Ribosomal_uL18_bac/plant/anim

Family

30,939

false

This family includes the large subunit ribosomal protein uL18 from bacteria, mitochondria and plastids. The large ribosomal subunit protein uL18 is an essential component of the large subunit LSU, which is required in its formation and stabilisation. The LSU contains the ribosomal catalytic site termed the peptidyl tra...

[ "GO:0003735", "GO:0006412", "GO:0005840" ]

[ "structural constituent of ribosome", "translation", "ribosome" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PFAM", "PANTHER" ]

[ "PF00861", "PTHR12899" ]

[ "Ribosomal_L18p", "" ]

[ 29410, 30581 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-5389840", "R-BTA-5419276", "R-BTA-9937383", "R-CEL-5389840", "R-CEL-5419276", "R-CEL-9937383", "R-HSA-5368286", "R-HSA-5389840", "R-HSA-5419276", "R-HSA-9937383", "R-MMU-5389840", "R-MMU-5419276", "R-MMU-9937383" ]

[ "REACTOME:R-BTA-5389840", "REACTOME:R-BTA-5419276", "REACTOME:R-BTA-9937383", "REACTOME:R-CEL-5389840", "REACTOME:R-CEL-5419276", "REACTOME:R-CEL-9937383", "REACTOME:R-HSA-5368286", "REACTOME:R-HSA-5389840", "REACTOME:R-HSA-5419276", "REACTOME:R-HSA-9937383", "REACTOME:R-MMU-5389840", "REACTOM...

13

[ "1ily", "1nkw", "1nwx", "1nwy", "1ovy", "1sm1", "1vvj", "1vy4", "1vy5", "1vy6", "1vy7", "1xbp", "2j28", "2rdo", "2zjp", "2zjq", "2zjr", "3bbx", "3cf5", "3dll", "3j3v", "3j5l", "3j7y", "3j7z", "3j8g", "3j9m", "3j9w", "3j9y", "3j9z", "3ja1", "3jbu", "3jbv"...

1,209

[ "PUB00007068", "PUB00007069", "PUB00007070", "PUB00030943", "PUB00079485", "PUB00097818" ]

[ "11297922", "11290319", "11114498", "15184028", "14527328", "12962325" ]

[ "Atomic structures at last: the ribosome in 2000.", "The ribosome in focus.", "The end of the beginning: structural studies of ribosomal proteins.", "The roles of ribosomal proteins in the structure assembly, and evolution of the large ribosomal subunit.", "The structural basis of large ribosomal subunit fu...

[ 2001, 2001, 2000, 2004, 2003, 2003 ]

6

[ "IPR057268" ]

[ "IPR004389" ]

1

0

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 23754, 6751, 434 ]

3

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 32, 1, 3, 2, 1, 2, 2, 27, 5, 37 ]

10

true

Family

Large ribosomal subunit protein uL18, bacterial/plantae/animalia

Ribosomal_uL18_bac/plant/anim

9

IPR005485

5,485

Large ribosomal subunit protein uL18, eukaryota/archaea

Rbsml_uL18_euk_arc

Family

8,607

false

This entry represents ribosomal protein uL18 from eukaryotes. The large ribosomal subunit protein uL18 is an essential component of the large subunit LSU, which is required in its formation and stabilisation. The LSU contains the ribosomal catalytic site termed the peptidyl transferase centre (PTC), which catalyses the...

[ "GO:0003735", "GO:0008097", "GO:0006412", "GO:0005840" ]

[ "structural constituent of ribosome", "5S rRNA binding", "translation", "ribosome" ]

[ "molecular_function", "molecular_function", "biological_process", "cellular_component" ]

4

[ "HAMAP", "PFAM", "PRINTS", "PANTHER" ]

[ "MF_01337_A", "PF17144", "PR00058", "PTHR23410" ]

[ "Ribosomal_uL18_A", "Ribosomal_L5e", "RIBOSOMALL5", "" ]

[ 6356, 8256, 7536, 8506 ]

4

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-156827", "R-BTA-1799339", "R-BTA-6791226", "R-BTA-72689", "R-BTA-72706", "R-BTA-975956", "R-BTA-975957", "R-CEL-156827", "R-CEL-1799339", "R-CEL-72689", "R-CEL-72706", "R-CEL-975956", "R-CEL-975957", "R-DDI-156827", "R-DDI-1799339", "R-DDI-72689", "R-DDI-72706", "R-DDI-97595...

[ "REACTOME:R-BTA-156827", "REACTOME:R-BTA-1799339", "REACTOME:R-BTA-6791226", "REACTOME:R-BTA-72689", "REACTOME:R-BTA-72706", "REACTOME:R-BTA-975956", "REACTOME:R-BTA-975957", "REACTOME:R-CEL-156827", "REACTOME:R-CEL-1799339", "REACTOME:R-CEL-72689", "REACTOME:R-CEL-72706", "REACTOME:R-CEL-9759...

69

[ "1ffk", "1jj2", "1k73", "1k8a", "1k9m", "1kc8", "1kd1", "1kqs", "1m1k", "1m90", "1ml5", "1n8r", "1nji", "1q7y", "1q81", "1q82", "1q86", "1qvf", "1qvg", "1s72", "1vq4", "1vq5", "1vq6", "1vq7", "1vq8", "1vq9", "1vqk", "1vql", "1vqm", "1vqn", "1vqo", "1vqp"...

634

[ "PUB00003687", "PUB00004566", "PUB00007068", "PUB00007069", "PUB00007070", "PUB00030943", "PUB00079485", "PUB00097818" ]

[ "8474444", "8219074", "11297922", "11290319", "11114498", "15184028", "14527328", "12962325" ]

[ "Yeast ribosomal protein L1 is required for the stability of newly synthesized 5S rRNA and the assembly of 60S ribosomal subunits.", "A rice (Oryza sativa L.) cDNA encodes a protein sequence homologous to the eukaryotic ribosomal 5S RNA-binding protein.", "Atomic structures at last: the ribosome in 2000.", "T...

[ 1993, 1993, 2001, 2001, 2000, 2004, 2003, 2003 ]

8

[ "IPR057268" ]

[ "IPR057267" ]

1

0

[ "Archaea", "Eukaryota", "Pseudomonadota", "ecological metagenomes" ]

[ 951, 7616, 6, 34 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 14, 1, 2, 5, 9, 6, 1, 6, 6, 1, 2, 17 ]

12

true

Family

Large ribosomal subunit protein uL18, eukaryota/archaea

Rbsml_uL18_euk_arc

2

IPR005486

5,486

Glucokinase regulatory protein, conserved site

Glucokinase_regulatory_CS

Conserved_site

12,034

false

The glucokinase regulatory protein (GCKR) [ ] is a vertebrate protein that inhibits glucokinase by forming a complex with the enzyme, which plays a role in the control of blood glucose homeostasis. GCKR is a protein of about 70 Kd which is evolutionary related to bacterial N-acetylmuramic acid 6-phosphate etherases (Mu...

[]

0

[ "PROSITE" ]

[ "PS01272" ]

[ "GCKR" ]

[ 12034 ]

1

[ "EC", "PROSITEDOC", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "4.2.1.126", "PDOC00979", "R-HSA-170822", "R-HSA-5619107", "R-MMU-170822", "R-RNO-170822" ]

[ "EC:4.2.1.126", "PROSITEDOC:PDOC00979", "REACTOME:R-HSA-170822", "REACTOME:R-HSA-5619107", "REACTOME:R-MMU-170822", "REACTOME:R-RNO-170822" ]

6

[ "1nri", "3w0l", "4bb9", "4bba", "4lc9", "4ly9", "4lzj", "4m0d", "4mqu", "4mro", "4msu", "4ohk", "4ohm", "4oho", "4ohp", "4olh", "4op1", "4op2", "4op3", "4px2", "4px3", "4px5", "4pxs", "4s12" ]

24

[ "PUB00001455", "PUB00070737" ]

[ "7925465", "18049859" ]

[ "Cloning and expression of a Xenopus liver cDNA encoding a fructose-phosphate-insensitive regulatory protein of glucokinase.", "N-acetylmuramic acid 6-phosphate lyases (MurNAc etherases): role in cell wall metabolism, distribution, structure, and mechanism." ]

[ 1994, 2008 ]

2

[]

0

null

[ "Bacteria", "Candidatus Sysuiplasma superficiale", "Eukaryota", "metagenomes" ]

[ 11059, 3, 888, 84 ]

4

[ "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 4, 1, 4 ]

4

true

Conserved_site

Glucokinase regulatory protein, conserved site

Glucokinase_regulatory_CS

4

IPR005488

5,488

N-acetylmuramic acid 6-phosphate etherase MurQ

Etherase_MurQ

Family

12,909

false

MurQ is involved in recycling components of the bacterial murein sacculus turned over during cell growth. The cell wall metabolite anhydro-N-acetylmuramic acid (anhMurNAc) is converted by a kinase, AnmK, to MurNAc-phosphate, then converted to N-acetylglucosamine-phosphate by this etherase, called MurQ [ , ].

[ "GO:0016835", "GO:0046348" ]

[ "carbon-oxygen lyase activity", "amino sugar catabolic process" ]

[ "molecular_function", "biological_process" ]

2

[ "HAMAP", "NCBIFAM", "CDD" ]

[ "MF_00068", "TIGR00274", "cd05007" ]

[ "MurQ", "", "SIS_Etherase" ]

[ 11284, 10789, 12881 ]

3

[ "EC", "GP", "GP" ]

[ "4.2.1.126", "GenProp0766", "GenProp1623" ]

[ "EC:4.2.1.126", "GP:GenProp0766", "GP:GenProp1623" ]

3

[ "1nri", "4lzj", "4m0d", "4s12" ]

4

[ "PUB00043012", "PUB00043013" ]

[ "15983044", "16452451" ]

[ "Scission of the lactyl ether bond of N-acetylmuramic acid by Escherichia coli \"etherase\".", "MurQ Etherase is required by Escherichia coli in order to metabolize anhydro-N-acetylmuramic acid obtained either from the environment or from its own cell wall." ]

[ 2005, 2006 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "Thermoplasmata", "metagenomes" ]

[ 12429, 390, 6, 84 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

N-acetylmuramic acid 6-phosphate etherase MurQ

Etherase_MurQ

8

IPR005489

5,489

Protein of unknown function DUF257

DUF257

Family

325

false

This family of proteins is of unknown function.

[]

0

[ "PFAM" ]

[ "PF03192" ]

[ "DUF257" ]

[ 325 ]

1

[]

0

[ "2ekd" ]

1

[]

0

[]

0

null

[ "Thermococcaceae" ]

[ 325 ]

1

[]

0

true

Family

Protein of unknown function DUF257

DUF257

7

IPR005491

5,491

ENT domain

ENT_dom

Domain

7,527

false

The EMSY N-terminal (ENT) domain is a ~90-residue module, which is unique in the human proteome, although multiple copies are found in Arabidopsis proteins. In the plant proteins, the ENT domains are accompanied by Agenet domains, plant specific homologues of Tudor domains [ , ]. The ENT domain consists of a unique arr...

[]

0

[ "PFAM", "PROFILE", "SMART" ]

[ "PF03735", "PS51138", "SM01191" ]

[ "ENT", "ENT", "ENT" ]

[ 7162, 7350, 7217 ]

3

[ "PROSITEDOC" ]

[ "PDOC51138" ]

[ "PROSITEDOC:PDOC51138" ]

1

[ "1utu", "1uz3", "2fmm" ]

3

[ "PUB00011247", "PUB00018569", "PUB00018571", "PUB00018572" ]

[ "12575993", "14651845", "15978617", "15947784" ]

[ "The Tudor domain 'Royal Family': Tudor, plant Agenet, Chromo, PWWP and MBT domains.", "EMSY links the BRCA2 pathway to sporadic breast and ovarian cancer.", "Crystal structure of the ENT domain of human EMSY.", "Binding of EMSY to HP1beta: implications for recruitment of HP1beta and BS69." ]

[ 2003, 2003, 2005, 2005 ]

4

[]

0

null

[ "Bacteria", "Eukaryota" ]

[ 80, 7447 ]

2

[ "Arabidopsis thaliana", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 36, 30, 2, 4, 4, 32, 8, 100 ]

8

true

Domain

ENT domain

ENT_dom

3

IPR005492

5,492

Leucine-rich glioma-inactivated , EPTP repeat

EPTP

Repeat

6,006

false

Mutations in the LGI/EPT gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein (also known as Leucine-rich glioma-inactivated protein) was seen to contain a 130 amino acid repeat in its C-terminal section, although a sub-domain of 50 amino acids has now been ...

[]

0

[ "PFAM" ]

[ "PF03736" ]

[ "EPTP" ]

[ 6006 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-5682910", "R-HSA-5682910", "R-HSA-9619665", "R-MMU-5682910", "R-RNO-5682910" ]

[ "REACTOME:R-BTA-5682910", "REACTOME:R-HSA-5682910", "REACTOME:R-HSA-9619665", "REACTOME:R-MMU-5682910", "REACTOME:R-RNO-5682910" ]

5

[ "5y2z", "5y31", "8hpy", "8hq1", "8hq2", "8y6b", "9kzc", "9kzt" ]

8

[ "PUB00007869", "PUB00011794" ]

[ "12217514", "12095917" ]

[ "The novel EPTP repeat defines a superfamily of proteins implicated in epileptic disorders.", "A common protein interaction domain links two recently identified epilepsy genes." ]

[ 2002, 2002 ]

2

[]

0

null

[ "Bacteria", "Eukaryota" ]

[ 126, 5880 ]

2

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 22, 20, 14, 19 ]

4

true

Repeat

Leucine-rich glioma-inactivated , EPTP repeat

EPTP

3

IPR005493

5,493

Ribonuclease E inhibitor RraA/RraA-like protein

RraA/RraA-like

Family

32,209

false

This entry represents the regulator of ribonuclease E activity A (RraA). These proteins contain a swivelling 3-layer β/β/α domain that appears to be mobile in most multi-domain proteins known to contain it. These proteins are structurally similar, and may have distant homology, to the phosphohistidine domain of pyruvat...

[]

0

[ "PFAM", "CDD" ]

[ "PF03737", "cd16841" ]

[ "RraA-like", "RraA_family" ]

[ 32206, 30727 ]

2

[]

0

[ "1j3l", "1nxj", "1q5x", "1vi4", "2c5q", "2pcn", "2yjt", "2yjv", "3c8o", "3k4i", "3noj", "5ir2", "5x15" ]

13

[ "PUB00017730", "PUB00078042" ]

[ "14499605", "24359411" ]

[ "The X-ray structure of Escherichia coli RraA (MenG), A protein inhibitor of RNA processing.", "Biochemical and structural analysis of RraA proteins to decipher their relationships with 4-hydroxy-4-methyl-2-oxoglutarate/4-carboxy-4-hydroxy-2-oxoadipate aldolases." ]

[ 2003, 2014 ]

2

[]

[ "IPR010203", "IPR014165", "IPR017120" ]

0

3

0

[ "Archaea", "Bacteria", "Cafeteria roenbergensis virus (strain BV-PW1)", "Eukaryota", "unclassified sequences" ]

[ 391, 26935, 1, 4462, 420 ]

5

[ "Arabidopsis thaliana", "Escherichia coli (strain K12)", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Zea mays" ]

[ 9, 1, 1, 7, 1, 6 ]

6

true

Family

Ribonuclease E inhibitor RraA/RraA-like protein

RraA/RraA-like

6

IPR005494

5,494

Glutathionylspermidine synthase, pre-ATP-grasp-like domain

GSPS_pre-ATP-grasp-like_dom

Domain

10,531

false

Glutathionylspermidine (GSP) synthetases of Trypanosomatidae and Escherichia coli couple hydrolysis of ATP (to ADP and Pi) with formation of an amide bond between spermidine and the glycine carboxylate of glutathione (gamma-Glu-Cys-Gly). In the pathogenic trypanosomatids, this reaction is the penultimate step in the bi...

[]

0

[ "PFAM" ]

[ "PF03738" ]

[ "GSP_synth" ]

[ 10531 ]

1

[ "EC" ]

[ "6.3.1" ]

[ "EC:6.3.1" ]

1

[ "2io7", "2io8", "2io9", "2ioa", "2iob", "2vob", "2vpm", "2vps", "3o98", "7uk6", "7uk7", "7uk8", "7uka" ]

13

[ "PUB00008407", "PUB00041749" ]

[ "7775463", "17124497" ]

[ "Glutathionylspermidine metabolism in Escherichia coli. Purification, cloning, overproduction, and characterization of a bifunctional glutathionylspermidine synthetase/amidase.", "Dual binding sites for translocation catalysis by Escherichia coli glutathionylspermidine synthetase." ]

[ 1995, 2006 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 9927, 516, 49, 39 ]

4

[ "Escherichia coli (strain K12)" ]

[ 3 ]

1

true

Domain

Glutathionylspermidine synthase, pre-ATP-grasp-like domain

GSPS_pre-ATP-grasp-like_dom

5

IPR005495

5,495

Permease LptG/LptF-related

LptG/LptF_permease

Family

30,508

false

Members of this family are predicted integral membrane proteins of about 350 amino acids long and containing about 6 transmembrane regions. Characterised members include LptF and LptG, two homologous tandem-encoded permeases of an export ATP transporter for lipopolysaccharide (LPS) assembly in most Gram-negative bacter...

[ "GO:0016020" ]

[ "membrane" ]

[ "cellular_component" ]

1

[ "PFAM", "PANTHER" ]

[ "PF03739", "PTHR33529" ]

[ "LptF_LptG", "" ]

[ 30505, 30289 ]

2

[]

0

[ "5l75", "5x5y", "6mhu", "6mhz", "6mi7", "6mi8", "6mit", "6mjp", "6s8g", "6s8h", "6s8n", "7efo", "8frl", "8frm", "8frn", "8fro", "8frp", "8ufg", "8ufh" ]

19

[ "PUB00074210" ]

[ "18375759" ]

[ "Identification of two inner-membrane proteins required for the transport of lipopolysaccharide to the outer membrane of Escherichia coli." ]

[ 2008 ]

1

[]

[ "IPR030922", "IPR030923" ]

0

2

0

[ "Bacteria", "Eukaryota", "unclassified Caudoviricetes", "unclassified sequences", "uncultured marine thaumarchaeote AD1000_06_A03" ]

[ 29702, 73, 3, 729, 1 ]

5

[ "Escherichia coli (strain K12)" ]

[ 2 ]

1

true

Family

Permease LptG/LptF-related

LptG/LptF_permease

3

IPR005496

5,496

Integral membrane protein TerC

Integral_membrane_TerC

Family

41,508

false

A family containing a number of integral membrane proteins is named after TerC protein. TerC has been implicated in resistance to tellurium, and may be involved in efflux of tellurium ions. The tellurite-resistant Escherichia coli strain KL53 was found during testing of a group of clinical isolates for antibiotic and h...

[ "GO:0016020" ]

[ "membrane" ]

[ "cellular_component" ]

1

[ "PFAM" ]

[ "PF03741" ]

[ "TerC" ]

[ 41508 ]

1

[]

0

[]

0

[ "PUB00008408", "PUB00076704", "PUB00085185" ]

[ "10069007", "18429937", "24612058" ]

[ "In vivo and in vitro cloning and phenotype characterization of tellurite resistance determinant conferred by plasmid pTE53 of a clinical isolate of Escherichia coli.", "Deletion of the chloroplast-localized AtTerC gene product in Arabidopsis thaliana leads to loss of the thylakoid membrane and to seedling lethal...

[ 1998, 2008, 2014 ]

3

[]

[ "IPR022301", "IPR022493" ]

0

2

0

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 31, 39771, 1193, 62, 451 ]

5

[ "Arabidopsis thaliana", "Escherichia coli (strain K12)", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 5, 4, 2, 8 ]

4

true

Family

Integral membrane protein TerC

Integral_membrane_TerC

3

IPR005497

5,497

Cytochrome b6-f complex, subunit 8

Cytochrome_b6-f_cplx_su8

Family

14,591

false

PetN is a small hydrophobic protein, crucial for cytochrome b6-f complex assembly and/or stability. It is found in bacteria and plants. Cytochrome b6-f complex is composed of 4 large subunits: cytochrome b6, subunit IV (17kDa polypeptide, petD), cytochrome f and the Rieske protein, as well as 4 small subunits: petG, pe...

[ "GO:0017004", "GO:0009512" ]

[ "cytochrome complex assembly", "cytochrome b6f complex" ]

[ "biological_process", "cellular_component" ]

2

[ "HAMAP", "PFAM" ]

[ "MF_00395", "PF03742" ]

[ "Cytb6_f_PetN", "PetN" ]

[ 13662, 14591 ]

2

[ "GP" ]

[ "GenProp1353" ]

[ "GP:GenProp1353" ]

1

[ "1q90", "1vf5", "2d2c", "2e74", "2e75", "2e76", "2zt9", "4h0l", "4h13", "4h44", "4i7z", "4ogq", "4pv1", "6rqf", "7qrm", "7r0w", "7zxy", "7zyv", "9es7", "9es8", "9es9" ]

21

[ "PUB00032072" ]

[ "14526088" ]

[ "Structure of the cytochrome b6f complex of oxygenic photosynthesis: tuning the cavity." ]

[ 2003 ]

1

[]

0

null

[ "Bacteria", "Eukaryota" ]

[ 273, 14318 ]

2

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 3, 3, 2 ]

3

true

Family

Cytochrome b6-f complex, subunit 8

Cytochrome_b6-f_cplx_su8

1

IPR005498

5,498

Type IV secretion system, VirB10/TraB/TrbI

T4SS_VirB10/TraB/TrbI

Family

12,084

false

This entry represents type IV secretion system proteins VirB10, TraB, TrwE and TrbI. Type IV secretion systems are found in plant and animal pathogens, as well as in symbiotic bacteria. The tumour-inducing (Ti) plasmid of Rhizobium radiobacter (Agrobacterium tumefaciens) encodes various DNA transfer systems: VirB, Tra ...

[]

0

[ "PFAM", "CDD" ]

[ "PF03743", "cd16429" ]

[ "TrbI", "VirB10" ]

[ 12082, 8587 ]

2

[ "GP" ]

[ "GenProp0485" ]

[ "GP:GenProp0485" ]

1

[ "2bhv", "3jqo", "3zbi", "6gyb", "6odi", "6x6j", "6x6k", "6x6l", "6x6s", "7muc", "7mue", "7muq", "7mus", "7muv", "7muw", "7muy", "7o3j", "7o3t", "7okn", "7spb", "7spc", "7spi", "7spj", "7spk", "8cb2", "8rt4", "8rt5", "8rt6", "8rt7", "8rt8", "8rta", "8rtb"...

37

[ "PUB00008409", "PUB00012609", "PUB00019242", "PUB00020483", "PUB00034400", "PUB00053381" ]

[ "8763954", "8655498", "10438776", "9679196", "1355084", "12169609" ]

[ "The conjugal transfer system of Agrobacterium tumefaciens octopine-type Ti plasmids is closely related to the transfer system of an IncP plasmid and distantly related to Ti plasmid vir genes.", "Analysis of the traLEKBP sequence and the TraP protein from three F-like plasmids: F, R100-1 and ColB2.", "Essential...

[ 1996, 1996, 1999, 1998, 1992, 2002 ]

6

[]

[ "IPR047695", "IPR048018" ]

0

2

0

[ "Bacteria", "Eukaryota", "metagenomes", "plasmids", "uncultured Caudovirales phage" ]

[ 11928, 63, 84, 8, 1 ]

5

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Type IV secretion system, VirB10/TraB/TrbI

T4SS_VirB10/TraB/TrbI

2

IPR005499

5,499

6-carboxyhexanoate--CoA ligase

BioW

Family

612

false

This family contains the enzyme 6-carboxyhexanoate-CoA ligase . This enzyme is involved in the first step of biotin synthesis, where it converts pimelate into pimeloyl-CoA [ ]. The enzyme requires magnesium as a cofactor and forms a homodimer [ , ]. This enzyme sometimes can be found as part of a bifunctional protein w...

[ "GO:0005524", "GO:0042410", "GO:0009102" ]

[ "ATP binding", "6-carboxyhexanoate-CoA ligase activity", "biotin biosynthetic process" ]

[ "molecular_function", "molecular_function", "biological_process" ]

3

[ "HAMAP", "PFAM", "NCBIFAM" ]

[ "MF_00668", "PF03744", "TIGR01204" ]

[ "BioW", "BioW", "bioW" ]

[ 405, 612, 320 ]

3

[ "EC", "METACYC" ]

[ "6.2.1.14", "PWY-6578" ]

[ "EC:6.2.1.14", "METACYC:PWY-6578" ]

2

[ "5flg", "5fll", "5fm0", "5g1f", "5tv5", "5tv6", "5tv8", "5tva" ]

8

[ "PUB00008410", "PUB00070726" ]

[ "1445232", "21437340" ]

[ "Investigation of the first step of biotin biosynthesis in Bacillus sphaericus. Purification and characterization of the pimeloyl-CoA synthase, and uptake of pimelate.", "Closing in on complete pathways of biotin biosynthesis." ]

[ 1992, 2011 ]

2

[]

0

null

[ "Bacteria", "Methanobacteriota", "metagenomes" ]

[ 543, 57, 12 ]

3

[]

0

true

Family

6-carboxyhexanoate--CoA ligase

BioW

1

IPR005500

5,500

Protein of unknown function DUF309

DUF309

Family

6,260

false

This family consists of eubacterial and archaebacterial proteins of unknown function. The proteins contain a motif HXXXEXX(W/Y) where X can be any amino acid. This motif is likely to be functionally important and may be involved in metal binding.

[]

0

[ "PFAM", "PANTHER" ]

[ "PF03745", "PTHR34796" ]

[ "DUF309", "" ]

[ 6213, 5439 ]

2

[]

0

[ "2cwy", "2cxd", "2ijq" ]

3

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "metagenomes" ]

[ 770, 4879, 548, 63 ]

4

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 4, 8, 5 ]

3

true

Family

Protein of unknown function DUF309

DUF309

8

IPR005501

5,501

LamB/YcsF/PxpA-like

Family

17,921

false

This entry includes LamB/YcsF/PxpA and related proteins. The lam locus of Emericella nidulans (Aspergillus nidulans) consists of two divergently transcribed genes, lamA and lamB, involved in the utilization of lactams such as 2-pyrrolidinone. Both genes are under the control of the positive regulatory gene amdR and are...

[]

0

[ "HAMAP", "NCBIFAM", "PFAM", "PANTHER" ]

[ "MF_00691", "NF003814", "PF03746", "PTHR30292" ]

[ "PxpA", "PRK05406.1-3", "LamB_YcsF", "" ]

[ 12047, 16846, 17921, 17811 ]

4

[ "EC", "METACYC", "METACYC" ]

[ "3.5.2.9", "PWY-4041", "PWY-7942" ]

[ "EC:3.5.2.9", "METACYC:PWY-4041", "METACYC:PWY-7942" ]

3

[ "1v6t", "1xw8", "2dfa", "2xu2" ]

4

[ "PUB00008411", "PUB00088732" ]

[ "1729609", "28830929" ]

[ "Molecular characterization of the lam locus and sequences involved in regulation by the AmdR protein of Aspergillus nidulans.", "Discovery of a widespread prokaryotic 5-oxoprolinase that was hiding in plain sight." ]

[ 1992, 2017 ]

2

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 91, 16577, 1064, 189 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

LamB/YcsF/PxpA-like

5

IPR005502

5,502

ADP-ribosylation/Crystallin J1

Ribosyl_crysJ1

Family

34,934

false

This entry represents enzymes that perform ADP-ribosylations, including ADP-ribosylhydrolase ARH1/3 from animals, which preferentially hydrolyses the scissile alpha-O-linkage attached to the anomeric C1'' position of ADP-ribose and acts on different substrates, such as proteins ADP-ribosylated on serine and threonine, ...

[]

0

[ "PFAM" ]

[ "PF03747" ]

[ "ADP_ribosyl_GH" ]

[ 34934 ]

1

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "3.2.2", "R-DRE-110362", "R-HSA-110362", "R-MMU-110362", "R-XTR-110362" ]

[ "EC:3.2.2", "REACTOME:R-DRE-110362", "REACTOME:R-HSA-110362", "REACTOME:R-MMU-110362", "REACTOME:R-XTR-110362" ]

5

[ "1t5j", "2cwc", "2foz", "2fp0", "2g4k", "2qty", "2woc", "2wod", "2woe", "2yzv", "2yzw", "3g9d", "3hfw", "3o5t", "5ovo", "5zqy", "6d36", "6d3a", "6dre", "6drh", "6g1p", "6g1q", "6g28", "6g2a", "6hgz", "6hh3", "6hh4", "6hh5", "6hoz", "6iux", "7akr", "7aks"...

43

[ "PUB00008413", "PUB00015931", "PUB00052772", "PUB00100280", "PUB00100282", "PUB00100283", "PUB00100284" ]

[ "2506427", "8505315", "19706507", "30343895", "33769608", "21498885", "30830864" ]

[ "Genes coding for the reversible ADP-ribosylation system of dinitrogenase reductase from Rhodospirillum rubrum.", "J1-crystallins of the cubomedusan jellyfish lens constitute a novel family encoded in at least three intronless genes.", "Mechanism of ADP-ribosylation removal revealed by the structure and ligand ...

[ 1989, 1993, 2009, 2018, 2021, 2011, 2019 ]

7

[]

[ "IPR012108", "IPR013479", "IPR049650" ]

0

3

0

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "metagenomes" ]

[ 489, 24570, 9368, 125, 382 ]

5

[ "Danio rerio", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus" ]

[ 9, 1, 10, 8, 1, 10 ]

6

true

Family

ADP-ribosylation/Crystallin J1

Ribosyl_crysJ1

6

IPR005503

5,503

Flagellar basal body-associated protein FliL

FliL

Family

14,606

false

This FliL protein controls the rotational direction of the flagella during chemotaxis [ ]. FliL is a cytoplasmic membrane protein associated with the basal body [ ].

[ "GO:0006935", "GO:0071973", "GO:0009425" ]

[ "chemotaxis", "bacterial-type flagellum-dependent cell motility", "bacterial-type flagellum basal body" ]

[ "biological_process", "biological_process", "cellular_component" ]

3

[ "PFAM", "PANTHER" ]

[ "PF03748", "PTHR35091" ]

[ "FliL", "" ]

[ 14589, 11969 ]

2

[ "GP" ]

[ "GenProp0886" ]

[ "GP:GenProp0886" ]

1

[ "6ahp", "6ahq", "7sgn", "7sgo", "7sgp", "9hmf" ]

6

[ "PUB00008414", "PUB00008415" ]

[ "3519573", "10439416" ]

[ "Sequence of the flaA (cheC) locus of Escherichia coli and discovery of a new gene.", "FliL is a membrane-associated component of the flagellar basal body of Salmonella." ]

[ 1986, 1999 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 14411, 11, 184 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Flagellar basal body-associated protein FliL

FliL

1

IPR005506

5,506

Protein of unknown function DUF312, ALF

DUF312_ALF

Repeat

1,597

false

This entry represents a set of repeats named ALF (Alanine-rich, AL - conserved Phenylalanine, F), which are found in a small family of secreted proteins of no known function. They may be involved in signal transduction [ ].

[]

0

[ "PFAM" ]

[ "PF03752" ]

[ "ALF" ]

[ 1597 ]

1

[]

0

[ "8w20", "8w22" ]

2

[ "PUB00016669" ]

[ "12625841" ]

[ "New knowledge from old: in silico discovery of novel protein domains in Streptomyces coelicolor." ]

[ 2003 ]

1

[]

0

null

[ "Actinomycetes" ]

[ 1597 ]

1

[]

0

true

Repeat

Protein of unknown function DUF312, ALF

DUF312_ALF

3

IPR005507

5,507

Human herpesvirus 6 immediate early protein

HHV6-IE

Family

141

false

The proteins in this family are poorly characterised, but an investigation [ ] has indicated that the immediate early protein is required for the down-regulation of MHC class I expression in dendritic cells. Human herpesvirus 6 immediate early protein is also referred to as U90.

[]

0

[ "PFAM" ]

[ "PF03753" ]

[ "HHV6-IE" ]

[ 141 ]

1

[]

0

[]

0

[ "PUB00008416" ]

[ "11596096" ]

[ "Human herpesvirus 6 downregulates major histocompatibility complex class I in dendritic cells." ]

[ 2001 ]

1

[]

0

null

[ "Homo sapiens", "Roseolovirus" ]

[ 2, 139 ]

2

[ "Homo sapiens" ]

[ 2 ]

1

true

Family

Human herpesvirus 6 immediate early protein

HHV6-IE

9

IPR005508

5,508

B3 domain-containing protein At2g31720-like

At2g31720-like

Family

3,964

false

This entry represents a group of uncharacterised plant proteins, including B3 domain-containing protein At2g31720 (also known as Protein AUXIN RESPONSE FACTOR 70) from Arabidopsis. These are DNA-binding proteins likely to be involved in stress response [ ].

[ "GO:0003677" ]

[ "DNA binding" ]

[ "molecular_function" ]

1

[ "PFAM", "PANTHER" ]

[ "PF03754", "PTHR31541" ]

[ "At2g31720-like", "" ]

[ 3259, 3747 ]

2

[]

0

[]

0

[ "PUB00097781" ]

[ "29462363" ]

[ "A Gene Regulatory Network for Cellular Reprogramming in Plant Regeneration." ]

[ 2018 ]

1

[]

0

null

[ "Eukaryota" ]

[ 3964 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica" ]

[ 102, 1 ]

2

true

Family

B3 domain-containing protein At2g31720-like

At2g31720-like

4

IPR005509

5,509

A-factor biosynthesis hotdog domain

AfsA_hotdog_dom

Domain

2,801

false

The AfsA family are key enzymes in A-factor biosynthesis, which is essential for streptomycin production and resistance. This domain is distantly related to the thioester dehydratase FabZ family and therefore has a Hotdog domain [ ].

[]

0

[ "PFAM" ]

[ "PF03756" ]

[ "AfsA" ]

[ 2801 ]

1

[ "EC", "METACYC", "METACYC", "METACYC" ]

[ "2.3.1.277", "PWY-7878", "PWY-7881", "PWY-7882" ]

[ "EC:2.3.1.277", "METACYC:PWY-7878", "METACYC:PWY-7881", "METACYC:PWY-7882" ]

4

[]

0

[ "PUB00055611" ]

[ "15307895" ]

[ "The Hotdog fold: wrapping up a superfamily of thioesterases and dehydratases." ]

[ 2004 ]

1

[]

0

null

[ "Bacteria", "metagenomes" ]

[ 2796, 5 ]

2

[]

0

true

Domain

A-factor biosynthesis hotdog domain

AfsA_hotdog_dom

1

IPR005510

5,510

CRISPR type III-associated RAMP protein Csm4

Csm4

Family

883

false

CRISPR is a term for Clustered Regularly Interspaced Short Palidromic Repeats. A number of protein families appear only in association with these repeats and are designated Cas (CRISPR associated) proteins. Members of this cas gene family are found in the mtube subtype of CRISPR/cas locus and designated Csm4, for CRISP...

[]

0

[ "NCBIFAM" ]

[ "TIGR01903" ]

[ "cas5_csm4" ]

[ 883 ]

1

[ "GP", "GP" ]

[ "GenProp0021", "GenProp0318" ]

[ "GP:GenProp0021", "GP:GenProp0318" ]

2

[ "4qts", "6ifk", "6ifl", "6ifn", "6ifr", "6ifu", "6ify", "6ifz", "6ig0", "6iqw", "6mua", "6mur", "6mus", "6mut", "6muu", "6nud", "6nue", "6o73", "6o74", "6o75", "6o78", "6o79", "6o7b", "6o7d", "6o7e", "6o7h", "6o7i", "6xn3", "6xn4", "6xn5", "6xn7", "7uzw"...

55

[ "PUB00014786", "PUB00159951" ]

[ "11788711", "27105119" ]

[ "A DNA repair system specific for thermophilic Archaea and bacteria predicted by genomic context analysis.", "Spatiotemporal Control of Type III-A CRISPR-Cas Immunity: Coupling DNA Degradation with the Target RNA Recognition." ]

[ 2002, 2016 ]

2

[]

0

null

[ "Archaea", "Bacteria", "metagenomes" ]

[ 81, 790, 12 ]

3

[]

0

true

Family

CRISPR type III-associated RAMP protein Csm4

Csm4

9

IPR005511

5,511

Senescence marker protein-30 (SMP-30)

SMP-30

Family

26,902

false

This entry represents members of the SMP-30/CGR1 family which act as lactonases such as regucalcin. Regucalcin (RGN) is a gluconolactonase ( ), converting D-glucono-1,5-lactone to D-gluconate, but also hydrolyses other carbohydrate lactones. This enzyme is required for the penultimate step in vitamin C biosynthesis. Fr...

[]

0

[ "PRINTS" ]

[ "PR01790" ]

[ "SMP30FAMILY" ]

[ 26902 ]

1

[ "EC", "METACYC", "METACYC", "METACYC", "METACYC" ]

[ "3.1.1.17", "PWY-2221", "PWY-5530", "PWY-7165", "PWY-8142" ]

[ "EC:3.1.1.17", "METACYC:PWY-2221", "METACYC:PWY-5530", "METACYC:PWY-7165", "METACYC:PWY-8142" ]

5

[ "2ghs", "3dr2", "3e5z", "3g4e", "3g4h", "4gn7", "4gn8", "4gn9", "4gna", "4gnb", "4gnc", "5d9b", "5d9c", "5d9d", "5gtq", "5gx1", "5gx2", "5gx3", "5gx4", "5gx5", "5xfe", "7plb", "7plc", "7pld", "7ris", "7riz", "8djf", "8djz", "8dk0" ]

29

[ "PUB00011463", "PUB00011526", "PUB00011527", "PUB00018983", "PUB00018984", "PUB00018985", "PUB00018986", "PUB00041654", "PUB00088925", "PUB00088926", "PUB00088927", "PUB00088928" ]

[ "1315924", "8232287", "9278268", "8348951", "1618342", "2177680", "9586564", "15966726", "20329768", "1482681", "16950779", "16019162" ]

[ "Reversible effect of calcium-binding protein regucalcin on the Ca(2+)-induced inhibition of deoxyuridine 5'-triphosphatase activity in rat liver cytosol.", "Regulatory effect of regucalcin on (Ca(2+)-Mg2+)-ATPase in rat liver plasma membranes: comparison with the activation by Mn2+ and Co2+.", "Inhibitory effe...

[ 1992, 1993, 1997, 1993, 1992, 1990, 1998, 2005, 2010, 1992, 2006, 2005 ]

12

[]

[ "IPR008367" ]

0

1

0

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 183, 21010, 5397, 312 ]

4

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus" ]

[ 3, 28, 2, 1, 1, 3 ]

6

true

Family

Senescence marker protein-30 (SMP-30)

SMP-30

4

IPR005512

5,512

PRONE domain

PRONE_dom

Domain

7,082

false

In plants, the small GTP-binding proteins called Rops work as signalling switches that control growth, development and plant responses to various environmental stimuli. Rop proteins (Rho of plants, Rac-like and atRac in Arabidopsis thaliana belong to the Rho family of Ras-related GTP-binding proteins that turn on signa...

[ "GO:0005085" ]

[ "guanyl-nucleotide exchange factor activity" ]

[ "molecular_function" ]

1

[ "PFAM", "PROFILE" ]

[ "PF03759", "PS51334" ]

[ "PRONE", "PRONE" ]

[ 7055, 7055 ]

2

[]

0

[ "2ntx", "2nty", "2wbl" ]

3

[ "PUB00042041", "PUB00043712", "PUB00043713", "PUB00043714" ]

[ "17218277", "15980860", "16415208", "16754995" ]

[ "Structural evidence for a common intermediate in small G protein-GEF reactions.", "A new family of RhoGEFs activates the Rop molecular switch in plants.", "Members of a novel class of Arabidopsis Rho guanine nucleotide exchange factors control Rho GTPase-dependent polar growth.", "Purification and crystalliz...

[ 2007, 2005, 2006, 2006 ]

4

[]

0

null

[ "Eukaryota" ]

[ 7082 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 67, 32, 110 ]

3

true

Domain

PRONE domain

PRONE_dom

3

IPR005513

5,513

Late embryogenesis abundant protein, LEA_1 subgroup

LEA_1

Family

2,030

false

LEA (late embryogenesis abundant) proteins were first identified in land plants. Plant LEA proteins have been found to accumulate to high levels during the last stage of seed formation (when a natural desiccation of the seed tissues takes place) and during periods of water deficit in vegetative organs. Later, LEA homol...

[ "GO:0009793" ]

[ "embryo development ending in seed dormancy" ]

[ "biological_process" ]

1

[ "PFAM", "PANTHER" ]

[ "PF03760", "PTHR33493" ]

[ "LEA_1", "" ]

[ 2025, 1898 ]

2

[]

0

[]

0

[ "PUB00009713", "PUB00088595", "PUB00088596", "PUB00088598" ]

[ "10681550", "18318901", "21034219", "20668063" ]

[ "Highly hydrophilic proteins in prokaryotes and eukaryotes are common during conditions of water deficit.", "LEA (late embryogenesis abundant) proteins and their encoding genes in Arabidopsis thaliana.", "LEA proteins during water stress: not just for plants anymore.", "Functional analysis of the group 4 late...

[ 2000, 2008, 2011, 2010 ]

4

[]

0

null

[ "Embryophyta" ]

[ 2030 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 8, 13, 10 ]

3

true

Family

Late embryogenesis abundant protein, LEA_1 subgroup

LEA_1

4

IPR005514

5,514

Chymotrypsin family Peptidase-S1

DUF316

Family

522

false

This is a family of trypsin-6 part of the chymotrypsin family S21, ie a serine peptidase. The C. elegans sequence ( ) is trypsin-6: all the active site residues are present (His90, Asp168, Ser267).

[]

0

[ "PFAM" ]

[ "PF03761" ]

[ "DUF316" ]

[ 522 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Opisthokonta" ]

[ 522 ]

1

[ "Caenorhabditis elegans" ]

[ 20 ]

1

true

Family

Chymotrypsin family Peptidase-S1

DUF316

6

IPR005515

5,515

Vitelline membrane outer layer protein I (VOMI)

VOMI

Family

2,578

false

Vitelline membrane outer layer protein I (VMO-I) is one of the proteins found in the outer layer of the vitelline membrane of eggs. VMO-I, lysozyme, and VMO-II are bound tightly to ovomucin fibrils of the egg yolk membrane. The structure of VMO-I [ ] consists of three β-sheets forming Greek key motifs, which are relate...

[]

0

[ "PFAM", "PANTHER", "CDD" ]

[ "PF03762", "PTHR18841", "cd00220" ]

[ "VOMI", "", "VMO-I" ]

[ 2576, 2419, 1054 ]

3

[]

0

[ "1vmo" ]

1

[ "PUB00008418", "PUB00008419" ]

[ "8131734", "8848836" ]

[ "Crystal structure of vitelline membrane outer layer protein I (VMO-I): a folding motif with homologous Greek key structures related by an internal three-fold symmetry.", "The beta-prism: a new folding motif." ]

[ 1994, 1996 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 63, 2513, 2 ]

3

[ "Caenorhabditis elegans", "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 18, 3, 2, 1, 2 ]

5

true

Family

Vitelline membrane outer layer protein I (VOMI)

VOMI

6

IPR005516

5,516

Remorin, C-terminal

Remorin_C

Domain

9,705

false

Remorins are plant-specific plasma membrane-associated proteins. In tobacco remorin co-purifies with lipid rafts. Most remorins have a variable, proline-rich N-half and a more conserved C-half that is predicted to form coiled coils. Consistent with this, circular dichroism studies have demonstrated that much of the pro...

[]

0

[ "PFAM" ]

[ "PF03763" ]

[ "Remorin_C" ]

[ 9705 ]

1

[]

0

[ "9f1f", "9f1g" ]

2

[ "PUB00008420" ]

[ "8989883" ]

[ "Cloning of a cDNA encoding a plasma membrane-associated, uronide binding phosphoprotein with physical properties similar to viral movement proteins." ]

[ 1996 ]

1

[]

0

null

[ "Luteolibacter flavescens", "Streptophytina" ]

[ 1, 9704 ]

2

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 85, 63, 162 ]

3

true

Domain

Remorin, C-terminal

Remorin_C

1

IPR005517

5,517

Translation elongation factor EFG/EF2, domain IV

Transl_elong_EFG/EF2_IV

Domain

66,440

false

Included in this entry is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins that is homologous to domain IV of EF-G. Eukaryotic cells harbor 2 protein synthesis systems: one localized in the cytoplasm, the other in the mitochondria. Most factors regulating mitochondrial protein synthesis are encoded by n...

[ "GO:0005525" ]

[ "GTP binding" ]

[ "molecular_function" ]

1

[ "PFAM", "SMART" ]

[ "PF03764", "SM00889" ]

[ "EFG_IV", "EFG_IV" ]

[ 66004, 65483 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-156902", "R-BTA-5358493", "R-BTA-5419276", "R-BTA-6798695", "R-BTA-8876725", "R-CEL-156902", "R-CEL-5358493", "R-CEL-5389840", "R-CEL-6798695", "R-DDI-156902", "R-DDI-5358493", "R-DDI-6798695", "R-DME-156902", "R-DME-5358493", "R-DME-5389840", "R-DME-6798695", "R-DME-8876725",...

[ "REACTOME:R-BTA-156902", "REACTOME:R-BTA-5358493", "REACTOME:R-BTA-5419276", "REACTOME:R-BTA-6798695", "REACTOME:R-BTA-8876725", "REACTOME:R-CEL-156902", "REACTOME:R-CEL-5358493", "REACTOME:R-CEL-5389840", "REACTOME:R-CEL-6798695", "REACTOME:R-DDI-156902", "REACTOME:R-DDI-5358493", "REACTOME:R...

56

[ "1dar", "1efg", "1elo", "1fnm", "1jqm", "1ktv", "1n0u", "1n0v", "1pn6", "1u2r", "1wdt", "1zm2", "1zm3", "1zm4", "1zm9", "1zn0", "2bm0", "2bm1", "2bv3", "2dy1", "2e1r", "2efg", "2j7k", "2mzw", "2npf", "2om7", "2p8w", "2p8x", "2p8y", "2p8z", "2rdo", "2xex"...

307

[ "PUB00014828", "PUB00027704", "PUB00033951", "PUB00033952", "PUB00033953", "PUB00033958", "PUB00033959", "PUB00080028", "PUB00080029", "PUB00080030", "PUB00080031", "PUB00080032", "PUB00080033", "PUB00095177" ]

[ "12471894", "16213500", "12932732", "15922593", "12762045", "12762009", "12762047", "11735030", "1935960", "1602493", "8159735", "10837219", "12932345", "25288752" ]

[ "Translational elongation factor G: a GTP-driven motor of the ribosome.", "How can elongation factors EF-G and EF-Tu discriminate the functional state of the ribosome using the same binding site?", "Elongation factors in protein biosynthesis.", "Elongation factors on the ribosome.", "Structural studies of e...

[ 2000, 2005, 2003, 2005, 2001, 2001, 2001, 2001, 1991, 1992, 1994, 2000, 2003, 2014 ]

14

[]

[ "IPR047872" ]

0

1

0

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 1008, 44355, 20249, 11, 817 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus",...

[ 29, 5, 18, 3, 1, 18, 32, 3, 25, 15, 3, 3, 28 ]

13

true

Domain

Translation elongation factor EFG/EF2, domain IV

Transl_elong_EFG/EF2_IV

8

IPR005518

5,518

Remorin, N-terminal

Remorin_N

Domain

1,644

false

Remorin binds both simple and complex galaturonides. The N-terminal region of remorin is proline rich, while the C-terminal region has been predicted to form a coiled-coil, that is expected to interact with other macromolecules, most likely DNA. Functional similarities between the behavior of the proteins and viral pro...

[]

0

[ "PFAM" ]

[ "PF03766" ]

[ "Remorin_N" ]

[ 1644 ]

1

[]

0

[]

0

[ "PUB00008420" ]

[ "8989883" ]

[ "Cloning of a cDNA encoding a plasma membrane-associated, uronide binding phosphoprotein with physical properties similar to viral movement proteins." ]

[ 1996 ]

1

[]

0

null

[ "Luteolibacter flavescens", "Spermatophyta" ]

[ 1, 1643 ]

2

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 15, 11, 20 ]

3

true

Domain

Remorin, N-terminal

Remorin_N

3

IPR005519

5,519

Acid phosphatase, class B-like

Acid_phosphat_B-like

Family

11,192

false

This family of class B acid phosphatases also contains a number of vegetative storage proteins (VPS25) [ ]. The acid phosphatase activity of VPS has been experimentally demonstrated [ ].

[]

0

[ "PFAM" ]

[ "PF03767" ]

[ "Acid_phosphat_B" ]

[ 11192 ]

1

[ "EC", "GP", "GP", "METACYC" ]

[ "3.1.3.2", "GenProp1301", "GenProp1658", "PWY-6348" ]

[ "EC:3.1.3.2", "GP:GenProp1301", "GP:GenProp1658", "METACYC:PWY-6348" ]

4

[ "1n8n", "1n9k", "1rmq", "1rmt", "1rmy", "1z5g", "1z5u", "1z88", "2aut", "2b82", "2b8j", "2g1a", "2heg", "2hf7", "2i33", "2i34", "3cz4", "3et4", "3et5", "3ocu", "3ocv", "3ocw", "3ocx", "3ocy", "3ocz", "3pct", "3sf0", "4fyp", "7cle", "7f7a", "7f7b", "7f7c"...

33

[ "PUB00008422", "PUB00077128" ]

[ "1639823", "23957885" ]

[ "The soybean vegetative storage proteins VSP alpha and VSP beta are acid phosphatases active on polyphosphates.", "Elucidating the evolutionary history and expression patterns of nucleoside phosphorylase paralogs (vegetative storage proteins) in Populus and the plant kingdom." ]

[ 1992, 2013 ]

2

[]

[ "IPR006423", "IPR010025", "IPR014403" ]

0

3

0

[ "Bacteria", "Eukaryota", "Thermoproteota", "Viruses", "metagenomes" ]

[ 6171, 4943, 8, 21, 49 ]

5

[ "Arabidopsis thaliana", "Escherichia coli (strain K12)", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 40, 1, 53, 23 ]

4

true

Family

Acid phosphatase, class B-like

Acid_phosphat_B-like

4

IPR005520

5,520

Attacin, N-terminal

Attacin_N

Domain

349

false

This domain is found in attacin and sarcotoxin, but not diptericin (which shares similarity to the C-terminal region of attacin). All these proteins are insect antibacterial proteins which are induced by the fat body and subsequently secreted into the hemolymph where they act synergistically to kill the invading microo...

[ "GO:0005576" ]

[ "extracellular region" ]

[ "cellular_component" ]

1

[ "PFAM" ]

[ "PF03768" ]

[ "Attacin_N" ]

[ 349 ]

1

[]

0

[]

0

[ "PUB00008423" ]

[ "7772280" ]

[ "Innate immunity of insects." ]

[ 1995 ]

1

[]

0

null

[ "Endopterygota" ]

[ 349 ]

1

[ "Drosophila melanogaster" ]

[ 16 ]

1

true

Domain

Attacin, N-terminal

Attacin_N

6

IPR005521

5,521

Attacin, C-terminal

Attacin_C

Domain

763

false

This domain is found in attacin, sarcotoxin and diptericin. All members of these proteins are insect antibacterial proteins which are induced by the fat body and subsequently secreted into the hemolymph where they act synergistically to kill the invading microorganism [ , ].

[ "GO:0042742", "GO:0005576" ]

[ "defense response to bacterium", "extracellular region" ]

[ "biological_process", "cellular_component" ]

2

[ "PFAM" ]

[ "PF03769" ]

[ "Attacin_C" ]

[ 763 ]

1

[]

0

[]

0

[ "PUB00008423", "PUB00087181" ]

[ "7772280", "2452654" ]

[ "Innate immunity of insects.", "Molecular cloning, sequencing, and characterization of cDNA for sarcotoxin IIA, an inducible antibacterial protein of Sarcophaga peregrina (flesh fly)." ]

[ 1995, 1988 ]

2

[]

0

null

[ "Pterygota" ]

[ 763 ]

1

[ "Drosophila melanogaster" ]

[ 20 ]

1

true

Domain

Attacin, C-terminal

Attacin_C

9