LiteFold/InterPro · Datasets at Hugging Face

IPR005284

5,284

Pigment precursor permease/Protein ATP-binding cassette sub-family G

Pigment_permease/Abcg

Family

880

false

This family includes pigment precursor permeases (protein white, brown and scarlet) from flies and ATP-binding cassette sub-family G member 1 (ABCG1) from mammals.

[ "GO:0055085", "GO:0016020" ]

[ "transmembrane transport", "membrane" ]

[ "biological_process", "cellular_component" ]

2

[ "NCBIFAM" ]

[ "TIGR00955" ]

[ "3a01204" ]

[ 880 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-DME-1369062", "R-DME-1660661", "R-DME-189451", "R-DME-189483", "R-DME-917937", "R-DME-9753281", "R-DME-9793528", "R-HSA-1369062", "R-HSA-8964058", "R-HSA-9029569", "R-MMU-1369062", "R-MMU-8964058" ]

[ "REACTOME:R-DME-1369062", "REACTOME:R-DME-1660661", "REACTOME:R-DME-189451", "REACTOME:R-DME-189483", "REACTOME:R-DME-917937", "REACTOME:R-DME-9753281", "REACTOME:R-DME-9793528", "REACTOME:R-HSA-1369062", "REACTOME:R-HSA-8964058", "REACTOME:R-HSA-9029569", "REACTOME:R-MMU-1369062", "REACTOME:R...

12

[ "7fdv", "7oz1", "7r8c", "7r8d", "7r8e" ]

5

[ "PUB00070272", "PUB00087189", "PUB00087190" ]

[ "14668945", "3149712", "21039336" ]

[ "Physiological function of ABCG1.", "The brown protein of Drosophila melanogaster is similar to the white protein and to components of active transport complexes.", "ATP-binding cassette transporters A1 and G1, HDL metabolism, cholesterol efflux, and inflammation: important targets for the treatment of atherosc...

[ 2003, 1988, 2011 ]

3

[]

0

null

[ "Eukaryota" ]

[ 880 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 2, 7, 4, 2, 3 ]

6

true

Family

Pigment precursor permease/Protein ATP-binding cassette sub-family G

Pigment_permease/Abcg

2

IPR005285

5,285

Pleiotropic drug resistance protein PDR/CDR

Drug-R_PDR/CDR

Family

639

false

This family consists of multidrug resistance ATP binding cassette (ABC) transporters from fungi. This family includes PDR10 and PDR15, members of the pleiotropic drug resistance (PDR) network in Saccharomyces cerevisiae [ ], and CDR transporters from Candida albicans [ , , ]. The ABC transporter family is a group of me...

[ "GO:0042626", "GO:1990961", "GO:0016020" ]

[ "ATPase-coupled transmembrane transporter activity", "xenobiotic detoxification by transmembrane export across the plasma membrane", "membrane" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "NCBIFAM" ]

[ "TIGR00956" ]

[ "3a01205" ]

[ 639 ]

1

[]

0

[ "7p03", "7p04", "7p05", "7p06", "9iuk", "9iul", "9ium" ]

7

[ "PUB00072552", "PUB00074972", "PUB00074973", "PUB00074974", "PUB00074977" ]

[ "11441126", "9428726", "9210670", "9043118", "25221515" ]

[ "The human ATP-binding cassette (ABC) transporter superfamily.", "The yeast ATP binding cassette (ABC) protein genes PDR10 and PDR15 are novel targets for the Pdr1 and Pdr3 transcriptional regulators.", "Increased mRNA levels of ERG16, CDR, and MDR1 correlate with increases in azole resistance in Candida albica...

[ 2001, 1997, 1997, 1997, 2014 ]

5

[]

0

null

[ "Fungi" ]

[ 639 ]

1

[ "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 4, 1 ]

2

true

Family

Pleiotropic drug resistance protein PDR/CDR

Drug-R_PDR/CDR

6

IPR005286

5,286

Cell division protein FtsE

Cell_div_FtsE

Family

15,662

false

This entry represents Cell division ATP-binding protein FtsE from Streptococcus pneumoniae and similar bacterial sequences. FtsE is an ABC transporter ATP-binding protein with as ATPase activity [ ]. This protein and its permease partner FtsX, localise to the cell division site. It is essential for cell division and vi...

[ "GO:0005524", "GO:0051301" ]

[ "ATP binding", "cell division" ]

[ "molecular_function", "biological_process" ]

2

[ "NCBIFAM" ]

[ "TIGR02673" ]

[ "FtsE" ]

[ 15662 ]

1

[]

0

[ "6z4w", "6z63", "6z67", "8hd0", "8i6o", "8i6q", "8i6r", "8i6s", "8idb", "8idc", "8idd", "8igq", "8jia", "8tzj", "8tzk", "8tzl", "8w6i", "8w6j", "8x61", "8y3x", "8ymc", "9iue" ]

22

[ "PUB00004290", "PUB00014769", "PUB00017894", "PUB00017895", "PUB00017896", "PUB00017897", "PUB00017898", "PUB00017899", "PUB00025109", "PUB00026406", "PUB00043654", "PUB00160960", "PUB00160961" ]

[ "9872322", "9873074", "11421269", "1282354", "9640644", "11988180", "11470432", "11402022", "11080142", "11532960", "11421270", "23860769", "27167971" ]

[ "Crystal structure of the ATP-binding subunit of an ABC transporter.", "Getting in or out: early segregation between importers and exporters in the evolution of ATP-binding cassette (ABC) transporters.", "ABC transporters: physiology, structure and mechanism--an overview.", "ABC transporters: from microorgani...

[ 1998, 1999, 2001, 1992, 1998, 2002, 2001, 2001, 2000, 2001, 2001, 2013, 2016 ]

13

[ "IPR015854" ]

[]

1

0

1

[ "Bacteria", "Candidatus Nitrosopumilus salarius BD31", "Eukaryota", "Siphoviridae sp. ctXQ92", "unclassified sequences" ]

[ 15407, 1, 9, 1, 244 ]

5

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Cell division protein FtsE

Cell_div_FtsE

4

IPR005287

5,287

Conserved hypothetical protein CHP00375

CHP00375

Family

300

false

This family of conserved hypothetical proteins has no known function.

[]

0

[ "NCBIFAM" ]

[ "TIGR00375" ]

[ "" ]

[ 300 ]

1

[]

0

[ "5zb8", "7k30", "7k31", "7k32", "7k33" ]

5

[]

0

[ "IPR059260" ]

[]

1

0

1

[ "Archaea", "Bacillales", "bioreactor metagenome" ]

[ 205, 94, 1 ]

3

[]

0

true

Family

Conserved hypothetical protein CHP00375

CHP00375

3

IPR005288

5,288

L-aspartate oxidase

NadB

Family

23,393

false

L-aspartate oxidase is the B protein, NadB, of the quinolinate synthetase complex. Quinolinate synthetase makes a precursor of the pyridine nucleotide portion of NAD.

[ "GO:0008734", "GO:0009435" ]

[ "L-aspartate oxidase activity", "NAD+ biosynthetic process" ]

[ "molecular_function", "biological_process" ]

2

[ "PANTHER", "NCBIFAM" ]

[ "PTHR42716", "TIGR00551" ]

[ "", "nadB" ]

[ 23393, 16390 ]

2

[ "EC", "GP", "GP", "METACYC", "METACYC" ]

[ "1.4.3.16", "GenProp0057", "GenProp1250", "PWY-5316", "PWY-7342" ]

[ "EC:1.4.3.16", "GP:GenProp0057", "GP:GenProp1250", "METACYC:PWY-5316", "METACYC:PWY-7342" ]

5

[ "1chu", "1knp", "1knr", "2e5v", "5kxj" ]

5

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 351, 21373, 1104, 565 ]

4

[ "Arabidopsis thaliana", "Escherichia coli (strain K12)", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 3, 1, 2, 8 ]

4

true

Family

L-aspartate oxidase

NadB

3

IPR005290

5,290

Small ribosomal subunit protein uS15, bacteria

Ribosomal_uS15_bact

Family

40,828

false

This family includes specifically bacterial, chloroplast, and mitochondrial ribosomal protein uS15. Ribosomes are the particles that catalyse mRNA-directed protein synthesis in all organisms. The codons of the mRNA are exposed on the ribosome to allow tRNA binding. This leads to the incorporation of amino acids into th...

[ "GO:0003735", "GO:0006412", "GO:0005840" ]

[ "structural constituent of ribosome", "translation", "ribosome" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "HAMAP", "PANTHER", "NCBIFAM" ]

[ "MF_01343_B", "PTHR23321", "TIGR00952" ]

[ "Ribosomal_uS15_B", "", "S15_bact" ]

[ 39337, 39400, 38667 ]

3

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-DME-5389840", "R-DME-5419276", "R-DME-9937383", "R-DRE-5389840", "R-DRE-5419276", "R-HSA-5368286", "R-HSA-5389840", "R-HSA-5419276", "R-HSA-9937383", "R-MMU-5389840", "R-MMU-5419276", "R-MMU-9937383", "R-RNO-5389840", "R-RNO-5419276", "R-RNO-9937383" ]

[ "REACTOME:R-DME-5389840", "REACTOME:R-DME-5419276", "REACTOME:R-DME-9937383", "REACTOME:R-DRE-5389840", "REACTOME:R-DRE-5419276", "REACTOME:R-HSA-5368286", "REACTOME:R-HSA-5389840", "REACTOME:R-HSA-5419276", "REACTOME:R-HSA-9937383", "REACTOME:R-MMU-5389840", "REACTOME:R-MMU-5419276", "REACTOM...

15

[ "1a32", "1ab3", "1dk1", "1eg0", "1f7y", "1fjg", "1fka", "1g1x", "1hnw", "1hnx", "1hnz", "1hr0", "1i94", "1i95", "1i96", "1i97", "1ibk", "1ibl", "1ibm", "1j5e", "1jgo", "1jgp", "1jgq", "1kuq", "1ml5", "1n32", "1n33", "1n34", "1n36", "1qd7", "1vvj", "1vy4"...

1,293

[ "PUB00007068", "PUB00007069", "PUB00007070", "PUB00007750" ]

[ "11297922", "11290319", "11114498", "12126618" ]

[ "Atomic structures at last: the ribosome in 2000.", "The ribosome in focus.", "The end of the beginning: structural studies of ribosomal proteins.", "Do mRNA and rRNA binding sites of E.coli ribosomal protein S15 share common structural determinants?" ]

[ 2001, 2001, 2000, 2002 ]

4

[ "IPR000589" ]

[]

1

0

1

[ "Bacteria", "Eukaryota", "unclassified sequences", "uncultured marine thaumarchaeote KM3_46_G10" ]

[ 23182, 17187, 458, 1 ]

4

[ "Arabidopsis thaliana", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae...

[ 10, 1, 1, 1, 1, 1, 1, 15, 3, 1, 1, 8 ]

12

true

Family

Small ribosomal subunit protein uS15, bacteria

Ribosomal_uS15_bact

1

IPR005292

5,292

Multi drug resistance-associated protein

MRP

Family

6,054

false

This family consists of multi drug resistance-associated proteins (MRPs) from eukaryotes, including MRP1/ABCC1 from human [, , , , ]. MRPs are integral membrane proteins that mediate export of organic anions and drugs from the cytoplasm, which cause multidrug resistance when overexpressed in mammalian cells. They belon...

[ "GO:0022857", "GO:0055085", "GO:0016020" ]

[ "transmembrane transporter activity", "transmembrane transport", "membrane" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "NCBIFAM" ]

[ "TIGR00957" ]

[ "MRP_assoc_pro" ]

[ 6054 ]

1

[ "EC", "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", ...

[ "7.6.2.2", "7.6.2.3", "PWY-4061", "PWY-4621", "PWY-6842", "PWY-6972", "PWY-8259", "PWY-8301", "R-BTA-1660661", "R-BTA-189483", "R-BTA-2142691", "R-BTA-382556", "R-BTA-9707564", "R-BTA-9753281", "R-BTA-9758890", "R-CEL-159418", "R-CEL-189483", "R-CEL-382556", "R-CEL-9749641", "R...

[ "EC:7.6.2.2", "EC:7.6.2.3", "METACYC:PWY-4061", "METACYC:PWY-4621", "METACYC:PWY-6842", "METACYC:PWY-6972", "METACYC:PWY-8259", "METACYC:PWY-8301", "REACTOME:R-BTA-1660661", "REACTOME:R-BTA-189483", "REACTOME:R-BTA-2142691", "REACTOME:R-BTA-382556", "REACTOME:R-BTA-9707564", "REACTOME:R-BT...

61

[ "5uj9", "5uja", "6bhu", "6uy0", "8f4b", "8hvh", "8hw2", "8hw4", "8izp", "8izq", "8izr", "8jx7", "8jxq", "8jxu", "8jy4", "8jy5", "8rq3", "8rq4", "8vt4", "8vux", "8vvc", "9br2", "9buk", "9c12", "9c2i", "9j9f", "9j9g", "9lg6", "9lg7", "9lg8", "9lg9", "9lga"...

37

[ "PUB00004290", "PUB00014769", "PUB00017894", "PUB00017895", "PUB00017896", "PUB00017897", "PUB00017898", "PUB00017899", "PUB00025109", "PUB00026406", "PUB00043654", "PUB00099634", "PUB00099635", "PUB00099636", "PUB00103853" ]

[ "9872322", "9873074", "11421269", "1282354", "9640644", "11988180", "11470432", "11402022", "11080142", "11532960", "11421270", "16230346", "15083066", "24266639", "36070769" ]

[ "Crystal structure of the ATP-binding subunit of an ABC transporter.", "Getting in or out: early segregation between importers and exporters in the evolution of ATP-binding cassette (ABC) transporters.", "ABC transporters: physiology, structure and mechanism--an overview.", "ABC transporters: from microorgani...

[ 1998, 1999, 2001, 1992, 1998, 2002, 2001, 2001, 2000, 2001, 2001, 2006, 2004, 2014, 2022 ]

15

[]

0

null

[ "Opisthokonta" ]

[ 6054 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 10, 13, 18, 14, 8, 19 ]

6

true

Family

Multi drug resistance-associated protein

MRP

9

IPR005295

5,295

IBV 3B protein

IBV_3B

Family

244

false

These proteins are the product of ORF 3B from Infectious bronchitis virus). Currently, the function of this protein remains unknown [ ].

[]

0

[ "PFAM" ]

[ "PF03622" ]

[ "IBV_3B" ]

[ 244 ]

1

[]

0

[]

0

[ "PUB00008387" ]

[ "9168126" ]

[ "Sequence analysis of gene 3, gene 4 and gene 5 of avian infectious bronchitis virus strain CU-T2." ]

[ 1997 ]

1

[]

0

null

[ "Orthocoronavirinae" ]

[ 244 ]

1

[]

0

true

Family

IBV 3B protein

IBV_3B

1

IPR005296

5,296

IBV 3C protein

IBV_3C

Family

385

false

These proteins are the product of ORF 3C from Infectious bronchitis virus. Currently, the function of this protein remains unknown.

[]

0

[ "HAMAP", "PFAM" ]

[ "MF_04206", "PF03620" ]

[ "GAMMA_CORONA_E", "IBV_3C" ]

[ 306, 385 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Gammacoronavirus" ]

[ 385 ]

1

[]

0

true

Family

IBV 3C protein

IBV_3C

8

IPR005297

5,297

Lipoprotein repeat

Lipoprotein_repeat

Repeat

6,858

false

This repeat is found in tandem in a set of lipoproteins. The alignment contains a Y-X4-D motif.

[]

0

[ "PFAM" ]

[ "PF03640" ]

[ "Lipoprotein_15" ]

[ 6858 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "ecological metagenomes" ]

[ 39, 6795, 4, 20 ]

4

[]

0

true

Repeat

Lipoprotein repeat

Lipoprotein_repeat

3

IPR005298

5,298

MAP domain

MAP_dom

Domain

190

false

Map (MHC class II analogous protein), also known as eap (extracellular adherence protein) and p70, is found in Staphylococcus aureus. It is a cell-wall associated protein, which is capable of binding to a number of different extracellular matrix glycoploteins and plasma proteins, and to the cell surface of S. aureus. B...

[]

0

[ "PFAM", "PROFILE" ]

[ "PF03642", "PS51223" ]

[ "MAP", "MAP" ]

[ 174, 184 ]

2

[ "PROSITEDOC" ]

[ "PDOC51223" ]

[ "PROSITEDOC:PDOC51223" ]

1

[ "1yn3", "1yn4", "1yn5", "4nzl", "6vtm", "8d4o", "8d4q", "8d4s", "8d4u", "8d4v", "8d7i", "8d7k", "8g24", "8g25", "8g26", "8gdg", "8gdh", "9ass", "9asx", "9atk", "9atu" ]

21

[ "PUB00008388", "PUB00035316", "PUB00035317" ]

[ "7545162", "14523103", "15691839" ]

[ "Staphylococcus aureus expresses a major histocompatibility complex class II analog.", "The adhesive and immunomodulating properties of the multifunctional Staphylococcus aureus protein Eap.", "The crystal structures of EAP domains from Staphylococcus aureus reveal an unexpected homology to bacterial superantig...

[ 1995, 2003, 2005 ]

3

[]

0

null

[ "Bacteria", "Eukaryota", "Methanobrevibacter filiformis", "Mus rat paramyxovirus" ]

[ 180, 8, 1, 1 ]

4

[]

0

true

Domain

MAP domain

MAP_dom

1

IPR005299

5,299

SAM dependent carboxyl methyltransferase

MeTrfase_7

Family

13,427

false

This family of plant methyltransferases contains enzymes that act on a variety of substrates including salicylic acid, jasmonic acid and 7-methylxanthine. Caffeine is synthesised through sequential three-step methylation of xanthine derivatives at positions 7-N, 3-N, and 1-N [ , ]. The protein 7-methylxanthine methyltr...

[ "GO:0008168" ]

[ "methyltransferase activity" ]

[ "molecular_function" ]

1

[ "PFAM", "PANTHER" ]

[ "PF03492", "PTHR31009" ]

[ "Methyltransf_7", "" ]

[ 13377, 13051 ]

2

[ "EC", "GP" ]

[ "2.1.1", "GenProp1420" ]

[ "EC:2.1.1", "GP:GenProp1420" ]

2

[ "1m6e", "2efj", "2eg5", "3b5i", "5f2k", "5f2n", "5f2o", "6c8r", "6c8s", "6lyh", "6lyi", "8uzd", "8wwq" ]

13

[ "PUB00008390", "PUB00040394", "PUB00096633", "PUB00153148" ]

[ "11108716", "17434991", "18068204", "34586497" ]

[ "7-Methylxanthine methyltransferase of coffee plants. Gene isolation and enzymatic properties.", "The structure of two N-methyltransferases from the caffeine biosynthetic pathway.", "Caffeine and related purine alkaloids: biosynthesis, catabolism, function and genetic engineering.", "Specific methylation of (...

[ 2001, 2007, 2008, 2021 ]

4

[]

0

null

[ "Bacteria", "Eukaryota", "ecological metagenomes" ]

[ 437, 12980, 10 ]

3

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 133, 122, 57 ]

3

true

Family

SAM dependent carboxyl methyltransferase

MeTrfase_7

1

IPR005301

5,301

MOB kinase activator family

MOB_kinase_act_fam

Family

18,953

false

The MOB kinase activator family includes MOB1, an essential Saccharomyces cerevisiae protein, identified from a two-hybrid screen, that binds Mps1p, a protein kinase essential for spindle pole body duplication and mitotic checkpoint regulation. Conditional alleles of MOB1 cause a late nuclear division arrest at restric...

[]

0

[ "PFAM", "PANTHER", "SMART" ]

[ "PF03637", "PTHR22599", "SM01388" ]

[ "Mob1_phocein", "", "Mob1_phocein" ]

[ 18902, 18498, 18669 ]

3

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-DME-2028269", "R-DME-390089", "R-DME-390098", "R-DME-390150", "R-HSA-2028269", "R-MMU-2028269", "R-RNO-2028269" ]

[ "REACTOME:R-DME-2028269", "REACTOME:R-DME-390089", "REACTOME:R-DME-390098", "REACTOME:R-DME-390150", "REACTOME:R-HSA-2028269", "REACTOME:R-MMU-2028269", "REACTOME:R-RNO-2028269" ]

7

[ "1pi1", "1r3b", "2hjn", "4j1v", "4jiz", "4lqp", "4lqq", "4lqs", "5b5v", "5b5w", "5b6b", "5brk", "5brm", "5ncl", "5ncm", "5ncn", "5twf", "5twg", "5twh", "5xqz", "5yf4", "6mcp", "6mcq", "7k36" ]

24

[ "PUB00008393", "PUB00074294" ]

[ "9436989", "11872741" ]

[ "MOB1, an essential yeast gene required for completion of mitosis and maintenance of ploidy.", "Interactions of phocein with nucleoside-diphosphate kinase, Eps15, and Dynamin I." ]

[ 1998, 2002 ]

2

[]

0

null

[ "Eukaryota" ]

[ 18953 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 16, 10, 20, 8, 20, 23, 5, 13, 30, 2, 2, 20 ]

12

true

Family

MOB kinase activator family

MOB_kinase_act_fam

3

IPR005302

5,302

Molybdenum cofactor sulfurase, C-terminal

MoCF_Sase_C

Domain

46,074

false

Molybdenum cofactor (MOCO) sulphurases [ ] catalyse the insertion of a terminal sulphur ligand into the molybdenum cofactor, thereby converting the oxo form of MOCO to a sulphurylated form. Suphurylated MOCO is required by several enzymes, including: aldehyde oxidase ( ), which function in the last step of abscisic aci...

[ "GO:0003824", "GO:0030151", "GO:0030170" ]

[ "catalytic activity", "molybdenum ion binding", "pyridoxal phosphate binding" ]

[ "molecular_function", "molecular_function", "molecular_function" ]

3

[ "PFAM", "PROFILE" ]

[ "PF03473", "PS51340" ]

[ "MOSC", "MOSC" ]

[ 44541, 45867 ]

2

[ "EC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "2.8.1.9", "PWY-5963", "R-BTA-211945", "R-BTA-947581", "R-CEL-947581", "R-DDI-947581", "R-DME-947581", "R-DRE-211945", "R-DRE-947581", "R-HSA-211945", "R-HSA-947581", "R-MMU-211945", "R-MMU-947581", "R-RNO-211945" ]

[ "EC:2.8.1.9", "METACYC:PWY-5963", "REACTOME:R-BTA-211945", "REACTOME:R-BTA-947581", "REACTOME:R-CEL-947581", "REACTOME:R-DDI-947581", "REACTOME:R-DME-947581", "REACTOME:R-DRE-211945", "REACTOME:R-DRE-947581", "REACTOME:R-HSA-211945", "REACTOME:R-HSA-947581", "REACTOME:R-MMU-211945", "REACTOM...

14

[ "1o65", "1o67", "1oru", "5yhh", "5yhi", "6fw2", "7p41" ]

7

[ "PUB00019067", "PUB00034759", "PUB00035521", "PUB00035522" ]

[ "11886751", "16784786", "11549764", "12650690" ]

[ "MOSC domains: ancient, predicted sulfur-carrier domains, present in diverse metal-sulfur cluster biosynthesis proteins including Molybdenum cofactor sulfurases.", "Cell biology of molybdenum.", "The Arabidopsis LOS5/ABA3 locus encodes a molybdenum cofactor sulfurase and modulates cold stress- and osmotic stres...

[ 2002, 2006, 2001, 2003 ]

4

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 674, 31616, 13334, 7, 443 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus",...

[ 15, 5, 6, 5, 2, 10, 5, 4, 6, 15, 30 ]

11

true

Domain

Molybdenum cofactor sulfurase, C-terminal

MoCF_Sase_C

7

IPR005303

5,303

Molybdenum cofactor sulfurase, middle domain

MOCOS_middle

Domain

23,797

false

This entry represents a domain located in the middle of Molybdenum cofactor sulfurases (MOCOS). MOCOS sulfurates the molybdenum cofactor [ ]. Mutations in this protein lead to a disorder characterised by excretion of very large amounts of xanthine in the urine and a tendency to form xanthine stones [ ]. This domain is ...

[]

0

[ "PFAM" ]

[ "PF03476" ]

[ "MOSC_N" ]

[ 23797 ]

1

[ "EC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "2.8.1.9", "PWY-5963", "R-BTA-211945", "R-BTA-947581", "R-CEL-947581", "R-DDI-947581", "R-DME-947581", "R-DRE-211945", "R-DRE-947581", "R-HSA-211945", "R-HSA-947581", "R-MMU-211945", "R-MMU-947581", "R-RNO-211945" ]

[ "EC:2.8.1.9", "METACYC:PWY-5963", "REACTOME:R-BTA-211945", "REACTOME:R-BTA-947581", "REACTOME:R-CEL-947581", "REACTOME:R-DDI-947581", "REACTOME:R-DME-947581", "REACTOME:R-DRE-211945", "REACTOME:R-DRE-947581", "REACTOME:R-HSA-211945", "REACTOME:R-HSA-947581", "REACTOME:R-MMU-211945", "REACTOM...

14

[ "2exn", "6fw2", "7p41" ]

3

[ "PUB00069600", "PUB00103854", "PUB00103855", "PUB00103856", "PUB00103857", "PUB00104737", "PUB00163267" ]

[ "11302742", "19053771", "16973608", "21029045", "30397129", "18312271", "35640667" ]

[ "Mutation of human molybdenum cofactor sulfurase gene is responsible for classical xanthinuria type II.", "The fourth molybdenum containing enzyme mARC: cloning and involvement in the activation of N-hydroxylated prodrugs.", "Identification of the missing component in the mitochondrial benzamidoxime prodrug-con...

[ 2001, 2008, 2006, 2011, 2018, 2008, 2022 ]

7

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "metagenomes" ]

[ 340, 11546, 11798, 2, 111 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus",...

[ 15, 5, 8, 4, 1, 9, 5, 3, 6, 13, 36 ]

11

true

Domain

Molybdenum cofactor sulfurase, middle domain

MOCOS_middle

8

IPR005304

5,304

Ribosomal biogenesis, methyltransferase, EMG1/NEP1

Rbsml_bgen_MeTrfase_EMG1/NEP1

Family

5,433

false

8S rRNA (pseudouridine(1248)-N1)-methyltransferase Nep1 (also known as EMG1) methylates pseudouridine at position1248 (Psi1248) in 18S rRNA and is required for small subunit (SSU) ribosomal RNA (rRNA) maturation [ ]. Mutations in the human homologue cause Bowen-Conradi Syndrome [ ]. Nep1 is a member of the SPOUT (SpoU-...

[ "GO:0070037", "GO:0070475" ]

[ "rRNA (pseudouridine) methyltransferase activity", "rRNA base methylation" ]

[ "molecular_function", "biological_process" ]

2

[ "PFAM", "PANTHER", "CDD" ]

[ "PF03587", "PTHR12636", "cd18088" ]

[ "EMG1", "", "Nep1-like" ]

[ 5412, 5342, 4870 ]

3

[ "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC"...

[ "2.1.1.-", "PWY-1061", "PWY-2083", "PWY-3542", "PWY-4021", "PWY-4161", "PWY-4202", "PWY-5059", "PWY-5105", "PWY-5301", "PWY-5305", "PWY-5479", "PWY-5665", "PWY-5729", "PWY-5748", "PWY-5765", "PWY-5773", "PWY-5846", "PWY-5883", "PWY-5975", "PWY-5987", "PWY-601", "PWY-6045"...

[ "EC:2.1.1.-", "METACYC:PWY-1061", "METACYC:PWY-2083", "METACYC:PWY-3542", "METACYC:PWY-4021", "METACYC:PWY-4161", "METACYC:PWY-4202", "METACYC:PWY-5059", "METACYC:PWY-5105", "METACYC:PWY-5301", "METACYC:PWY-5305", "METACYC:PWY-5479", "METACYC:PWY-5665", "METACYC:PWY-5729", "METACYC:PWY-5...

153

[ "2v3j", "2v3k", "3bbd", "3bbe", "3bbh", "3o7b", "3oii", "3oij", "3oin", "5fai", "5jpq", "5oql", "5tzs", "5wlc", "5wyj", "5wyk", "6ke6", "6lqp", "6lqq", "6lqr", "6lqs", "6lqt", "6lqu", "6lqv", "6rxt", "6rxu", "6rxv", "6rxx", "6rxy", "6rxz", "6zqa", "6zqb"...

66

[ "PUB00019919", "PUB00044726", "PUB00096286", "PUB00096304" ]

[ "11935223", "18063569", "20047967", "21087996" ]

[ "Nep1p (Emg1p), a novel protein conserved in eukaryotes and archaea, is involved in ribosome biogenesis.", "The yeast ribosome synthesis factor Emg1 is a novel member of the superfamily of alpha/beta knot fold methyltransferases.", "The ribosome assembly factor Nep1 responsible for Bowen-Conradi syndrome is a p...

[ 2002, 2008, 2010, 2011 ]

4

[]

[ "IPR023503" ]

0

1

0

[ "Archaea", "Eukaryota", "ecological metagenomes" ]

[ 313, 5099, 21 ]

3

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 5, 1, 1, 3, 8, 3, 2, 2, 4, 1, 1, 7 ]

12

true

Family

Ribosomal biogenesis, methyltransferase, EMG1/NEP1

Rbsml_bgen_MeTrfase_EMG1/NEP1

2

IPR005305

5,305

Nepovirus coat protein, C-terminal

Nepo_coat_C

Domain

925

false

Nepoviruses are plant viruses that, together with comoviruses and picornaviruses, are classified in the picornavirus superfamily of plus strand single-stranded RNA viruses. Its genome consist of two single-stranded RNAs, both required for infection [ ]. This domain aligns several nepovirus coat protein sequences. In se...

[ "GO:0019028" ]

[ "viral capsid" ]

[ "cellular_component" ]

1

[ "PFAM" ]

[ "PF03688" ]

[ "Nepo_coat_C" ]

[ 925 ]

1

[]

0

[ "1a6c", "2y26", "4v5t", "4v5w", "5foj" ]

5

[ "PUB00007724", "PUB00099814" ]

[ "9519407", "34370094" ]

[ "The structure of tobacco ringspot virus: a link in the evolution of icosahedral capsids in the picornavirus superfamily.", "Metagenomic analysis of nepoviruses: diversity, evolution and identification of a genome region in members of subgroup A that appears to be important for host range." ]

[ 1998, 2021 ]

2

[]

0

null

[ "Parasteatoda tepidariorum", "Viruses" ]

[ 1, 924 ]

2

[]

0

true

Domain

Nepovirus coat protein, C-terminal

Nepo_coat_C

1

IPR005306

5,306

Nepovirus coat protein, N-terminal

Nepo_coat_N

Domain

925

false

Nepoviruses are plant viruses that, together with comoviruses and picornaviruses, are classified in the picornavirus superfamily of plus strand single-stranded RNA viruses. Its genome consist of two single-stranded RNAs, both required for infection [ ]. This family includes several nepovirus coat protein sequences. In ...

[ "GO:0019028" ]

[ "viral capsid" ]

[ "cellular_component" ]

1

[ "PFAM" ]

[ "PF03689" ]

[ "Nepo_coat_N" ]

[ 925 ]

1

[]

0

[ "1a6c", "2y26", "4v5t", "4v5w", "5foj" ]

5

[ "PUB00007724", "PUB00099814" ]

[ "9519407", "34370094" ]

[ "The structure of tobacco ringspot virus: a link in the evolution of icosahedral capsids in the picornavirus superfamily.", "Metagenomic analysis of nepoviruses: diversity, evolution and identification of a genome region in members of subgroup A that appears to be important for host range." ]

[ 1998, 2021 ]

2

[]

0

null

[ "Parasteatoda tepidariorum", "Viruses" ]

[ 1, 924 ]

2

[]

0

true

Domain

Nepovirus coat protein, N-terminal

Nepo_coat_N

3

IPR005308

5,308

Orn/Lys/Arg decarboxylase, N-terminal

OKR_de-COase_N

Domain

10,108

false

This domain has a flavodoxin-like fold, and is termed the "wing" domain because of its position in the overall 3D structure. Ornithine decarboxylase from Lactobacillus 30a (L30a OrnDC, ) is representative of the large, pyridoxal-5'-phosphate-dependent decarboxylases that act on lysine, arginine or ornithine. The crysta...

[ "GO:0016831" ]

[ "carboxy-lyase activity" ]

[ "molecular_function" ]

1

[ "PFAM" ]

[ "PF03709" ]

[ "OKR_DC_1_N" ]

[ 10108 ]

1

[ "EC", "GP", "GP", "GP" ]

[ "4.1.1", "GenProp1279", "GenProp1433", "GenProp1596" ]

[ "EC:4.1.1", "GP:GenProp1279", "GP:GenProp1433", "GP:GenProp1596" ]

4

[ "1c4k", "1ord", "2vyc", "3n75", "3q16", "4upb", "4upf", "5fkx", "5fkz", "5fl2", "5xx1", "6q6i", "6q7l", "6q7m", "6y3x", "6yn5", "6yn6", "7p9b", "7pk6", "9e0m", "9e0o", "9e0q" ]

22

[ "PUB00003351" ]

[ "7563080" ]

[ "Crystallographic structure of a PLP-dependent ornithine decarboxylase from Lactobacillus 30a to 3.0 A resolution." ]

[ 1995 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "Methanomicrobia", "unclassified sequences" ]

[ 10035, 11, 30, 32 ]

4

[ "Escherichia coli (strain K12)" ]

[ 5 ]

1

true

Domain

Orn/Lys/Arg decarboxylase, N-terminal

OKR_de-COase_N

8

IPR005309

5,309

PapG, chaperone-binding

PapG_chaper-bd_C

Domain

95

false

PapG, the adhesin of the P-pili, is situated at the tip and is only a minor component of the whole pilus structure. A two-domain structure has been postulated for PapG; a carbohydrate binding N terminus and chaperone binding C terminus (this domain). The chaperone-binding domain is highly conserved, and is essential fo...

[]

0

[ "PFAM" ]

[ "PF03628" ]

[ "PapG_C" ]

[ 95 ]

1

[ "REACTOME" ]

[ "R-HSA-9638630" ]

[ "REACTOME:R-HSA-9638630" ]

1

[ "2wmp", "3me0", "6cd2", "7lhg", "7lhh", "7lhi" ]

6

[ "PUB00008963", "PUB00008964" ]

[ "11454740", "11440716" ]

[ "The solution structure of PapGII from uropathogenic Escherichia coli and its recognition of glycolipid receptors.", "Structural basis of the interaction of the pyelonephritic E. coli adhesin to its human kidney receptor." ]

[ 2001, 2001 ]

2

[]

0

null

[ "Bacteria", "Halohasta litorea" ]

[ 94, 1 ]

2

[]

0

true

Domain

PapG, chaperone-binding

PapG_chaper-bd_C

2

IPR005310

5,310

PapG, carbohydrate-binding domain

PapG_carb-bd_N

Domain

92

false

PapG, the adhesin of the P-pili, is situated at the tip and is only a minor component of the whole pilus structure. A two-domain structure has been postulated for PapG; a carbohydrate binding N terminus (this domain) and chaperone binding C terminus. The carbohydrate-binding domain interacts with the receptor glycan [ ...

[ "GO:0030246", "GO:0007155" ]

[ "carbohydrate binding", "cell adhesion" ]

[ "molecular_function", "biological_process" ]

2

[ "PFAM", "CDD" ]

[ "PF03627", "cd00239" ]

[ "PapG_N", "PapG_CBD" ]

[ 92, 64 ]

2

[ "REACTOME" ]

[ "R-HSA-9638630" ]

[ "REACTOME:R-HSA-9638630" ]

1

[ "1j8r", "1j8s", "4z3e", "4z3f", "4z3g", "4z3h", "4z3i", "4z3j", "6cd2", "7lhg", "7lhh", "7lhi" ]

12

[ "PUB00008963", "PUB00008964", "PUB00080442" ]

[ "11454740", "11440716", "2898842" ]

[ "The solution structure of PapGII from uropathogenic Escherichia coli and its recognition of glycolipid receptors.", "Structural basis of the interaction of the pyelonephritic E. coli adhesin to its human kidney receptor.", "Tip proteins of pili associated with pyelonephritis: new candidates for vaccine develop...

[ 2001, 2001, 1988 ]

3

[]

0

null

[ "Enterobacteriaceae" ]

[ 92 ]

1

[]

0

true

Domain

PapG, carbohydrate-binding domain

PapG_carb-bd_N

5

IPR005311

5,311

Penicillin-binding protein, dimerisation domain

PBP_dimer

Domain

62,368

false

This entry represents the N terminus domain of Class B High Molecular Weight Penicillin-Binding Proteins. Its function has not been precisely defined, but is strongly implicated in PBP polymerisation. The domain forms a largely disordered "sugar tongs" structure.

[ "GO:0008658" ]

[ "penicillin binding" ]

[ "molecular_function" ]

1

[ "PFAM" ]

[ "PF03717" ]

[ "PBP_dimer" ]

[ 62368 ]

1

[ "EC", "METACYC", "METACYC" ]

[ "3.4.16.4", "PWY-5265", "PWY-6471" ]

[ "EC:3.4.16.4", "METACYC:PWY-5265", "METACYC:PWY-6471" ]

3

[ "1k25", "1mwr", "1mws", "1mwt", "1mwu", "1pmd", "1pyy", "1qme", "1qmf", "1rp5", "1vqq", "2wad", "2wae", "2waf", "2z2l", "2z2m", "2zc3", "2zc4", "3equ", "3eqv", "3oc2", "3ocl", "3ocn", "3pbn", "3pbo", "3pbq", "3pbr", "3pbs", "3pbt", "3ue3", "3vsk", "3vsl"...

186

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Siphoviridae sp. ctBLh2", "unclassified sequences", "uncultured marine group II/III euryarchaeote KM3_94_C01" ]

[ 61159, 96, 1, 1111, 1 ]

5

[ "Escherichia coli (strain K12)" ]

[ 2 ]

1

true

Domain

Penicillin-binding protein, dimerisation domain

PBP_dimer

2

IPR005312

5,312

Domain of unknown function DUF1759

DUF1759

Domain

22,659

false

This is a domain of unknown function found in eukaryotic proteins related to gag-polyproteins.

[]

0

[ "PFAM" ]

[ "PF03564" ]

[ "DUF1759" ]

[ 22659 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota" ]

[ 7, 22652 ]

2

[ "Danio rerio", "Drosophila melanogaster" ]

[ 69, 6 ]

2

true

Domain

Domain of unknown function DUF1759

DUF1759

8

IPR005313

5,313

Peptidase N2

Peptidase_N2

Family

50

false

The asparagine endopeptidases are all autocatalytic endopeptidases utilizing Asn at position P1. Cleavage occurs as a consequence of cyclization of the Asn residue [ ]. This group of peptidases belongs to the MEROPS family N2 (clan NA). In the Nudaurelia capensis omega virus capsid protein the residues that form the ca...

[]

0

[ "PFAM", "PIRSF" ]

[ "PF03566", "PIRSF007212" ]

[ "Peptidase_A21", "Peptidase_A21" ]

[ 50, 30 ]

2

[]

0

[ "1ohf", "2qqp", "3s6p", "7anm", "7ata", "8a3c", "8a41", "8a6j", "8aay", "8ac6", "8ach" ]

11

[ "PUB00054229", "PUB00054233" ]

[ "16246842", "15659373" ]

[ "FlhB regulates ordered export of flagellar components via autocleavage mechanism.", "Folding and particle assembly are disrupted by single-point mutations near the autocatalytic cleavage site of Nudaurelia capensis omega virus capsid protein." ]

[ 2005, 2005 ]

2

[]

0

null

[ "Lutzomyia longipalpis", "Riboviria" ]

[ 1, 49 ]

2

[]

0

true

Family

Peptidase N2

Peptidase_N2

5

IPR005314

5,314

Peptidase C50, separase

Peptidase_C50

Family

5,038

false

This group of cysteine peptidases belong to MEROPS peptidase family C50 (separase family, clan CD). The active site residues for members of this family and family C14 occur in the same order in the sequence: H,C. The separases are caspase-like proteases, which plays a central role in the chromosome segregation. In yeas...

[ "GO:0004197", "GO:0006508", "GO:0005634" ]

[ "cysteine-type endopeptidase activity", "proteolysis", "nucleus" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PANTHER" ]

[ "PTHR12792" ]

[ "" ]

[ 5038 ]

1

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "3.4.22.49", "R-CEL-2467813", "R-HSA-2467813", "R-MMU-2467813", "R-SCE-2467813", "R-SPO-2467813" ]

[ "EC:3.4.22.49", "REACTOME:R-CEL-2467813", "REACTOME:R-HSA-2467813", "REACTOME:R-MMU-2467813", "REACTOME:R-SCE-2467813", "REACTOME:R-SPO-2467813" ]

6

[ "5fby", "5fc2", "5fc3", "5mz6", "5u1s", "5u1t", "7nj0", "7nj1", "9hm7", "9hma", "9hms", "9hn0", "9hn4", "9hn5" ]

14

[ "PUB00011704", "PUB00020025", "PUB00030423", "PUB00076953" ]

[ "11517925", "9891971", "14725770", "7044372" ]

[ "Evolutionary lines of cysteine peptidases.", "Identification of the active site of legumain links it to caspases, clostripain and gingipains in a new clan of cysteine endopeptidases.", "The structure of sortase B, a cysteine transpeptidase that tethers surface protein to the Staphylococcus aureus cell wall.", ...

[ 2001, 1998, 2004, 1982 ]

4

[]

0

null

[ "Eukaryota" ]

[ 5038 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 10, 2, 3, 1, 3, 6, 1, 3, 3, 1, 1, 11 ]

12

true

Family

Peptidase C50, separase

Peptidase_C50

5

IPR005315

5,315

Peptidase C8, hypovirus

Peptidase_C8

Family

29

false

This group of cysteine peptidases belong to MEROPS peptidase family C8 (clan CA). The peptidases are encoded by the double stranded viral RNAs belonging to the genus Hypovirus. A cysteine peptidase is a proteolytic enzyme that hydrolyses a peptide bond using the thiol group of a cysteine residue as a nucleophile. Hydro...

[]

0

[ "PFAM", "PROFILE" ]

[ "PF03569", "PS51875" ]

[ "Peptidase_C8", "HAV_P48_PRO" ]

[ 29, 29 ]

2

[]

0

[]

0

[ "PUB00011704", "PUB00020025", "PUB00030423", "PUB00076953" ]

[ "11517925", "9891971", "14725770", "7044372" ]

[ "Evolutionary lines of cysteine peptidases.", "Identification of the active site of legumain links it to caspases, clostripain and gingipains in a new clan of cysteine endopeptidases.", "The structure of sortase B, a cysteine transpeptidase that tethers surface protein to the Staphylococcus aureus cell wall.", ...

[ 2001, 1998, 2004, 1982 ]

4

[]

0

null

[ "Alphahypovirus" ]

[ 29 ]

1

[]

0

true

Family

Peptidase C8, hypovirus

Peptidase_C8

9

IPR005317

5,317

Dipeptidyl-peptidase 3

Dipeptidyl-peptase3

Family

3,073

false

This entry represents dipeptidyl peptidase 3 ( ), the best characterised member of Peptidase family M49. The dipeptidyl peptidase III aminopeptidases are zinc-dependent enzymes that cleave dipeptides from the N-terminal of peptides consisting of four or more amino acids and have a broad specificity. The active site res...

[ "GO:0008235", "GO:0008239", "GO:0006508", "GO:0005737" ]

[ "metalloexopeptidase activity", "dipeptidyl-peptidase activity", "proteolysis", "cytoplasm" ]

[ "molecular_function", "molecular_function", "biological_process", "cellular_component" ]

4

[ "PIRSF" ]

[ "PIRSF007828" ]

[ "Dipeptidyl-peptidase_III" ]

[ 3073 ]

1

[ "EC", "REACTOME", "REACTOME" ]

[ "3.4.14.4", "R-HSA-8951664", "R-HSA-9755511" ]

[ "EC:3.4.14.4", "REACTOME:R-HSA-8951664", "REACTOME:R-HSA-9755511" ]

3

[ "3csk", "3fvy", "3t6b", "3t6j", "5e2q", "5e33", "5e3a", "5e3c", "5egy", "5ehh", "5yfb", "5yfc", "5yfd", "7oup" ]

14

[ "PUB00089698", "PUB00089699" ]

[ "10387075", "18550518" ]

[ "The HELLGH motif of rat liver dipeptidyl peptidase III is involved in zinc coordination and the catalytic activity of the enzyme.", "The first structure of dipeptidyl-peptidase III provides insight into the catalytic mechanism and mode of substrate binding." ]

[ 1999, 2008 ]

2

[ "IPR039461" ]

[]

1

0

1

[ "Eukaryota", "Terrestrivirus sp." ]

[ 3072, 1 ]

2

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)" ]

[ 2, 1, 2, 7, 6, 1, 3, 1 ]

8

true

Family

Dipeptidyl-peptidase 3

Dipeptidyl-peptase3

4

IPR005318

5,318

Outer membrane porin, bacterial

OM_porin_bac

Family

15,936

false

This family contains bacterial outer membrane porins with serine protease activity [ ], including Chitoporin from Escherichia coli (ChiP) and Porin D from Pseudomonas aeruginosa (OprD). ChiP is involved in the uptake of chitosugars [ , ]. OprD shows specificity for basic amino acids [ , , ] and is involved in facilitat...

[ "GO:0015288", "GO:0016020" ]

[ "porin activity", "membrane" ]

[ "molecular_function", "cellular_component" ]

2

[ "PFAM", "PANTHER" ]

[ "PF03573", "PTHR34596" ]

[ "OprD", "" ]

[ 15730, 15436 ]

2

[]

0

[ "2odj", "2qtk", "2y0h", "2y0k", "2y0l", "2y2x", "3jty", "3sy7", "3sy9", "3syb", "3sys", "3szd", "3szv", "3t0s", "3t20", "3t24", "4fms", "4foz", "4frt", "4frx", "4fso", "4fsp", "4ft6", "5dl5", "5dl6", "5dl7", "5dl8", "7vtz", "7vu0", "7vu1", "7vu2", "7vu3"...

32

[ "PUB00007751", "PUB00059112", "PUB00065014", "PUB00159691", "PUB00159869", "PUB00161017", "PUB00161018" ]

[ "9636669", "22272184", "23467408", "16857666", "19682266", "2109575", "2118530" ]

[ "Identification of the catalytic triad of the protein D2 protease in Pseudomonas aeruginosa.", "Substrate specificity within a family of outer membrane carboxylate channels.", "Towards understanding the outer membrane uptake of small molecules by Pseudomonas aeruginosa.", "Comparative genomics and experimenta...

[ 1998, 2012, 2013, 2006, 2009, 1990, 1990 ]

7

[]

[ "IPR058075" ]

0

1

0

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 15852, 34, 50 ]

3

[ "Escherichia coli (strain K12)" ]

[ 2 ]

1

true

Family

Outer membrane porin, bacterial

OM_porin_bac

6

IPR005319

5,319

Peptidase S48, DNA-binding transcriptional activator HetR

Pept_S48_HetR

Family

216

false

HetR serine peptidases are associated with heterocystous cyanobacteria and belong to MEROPS peptidase family S48 (clan S-). HetR is a DNA-binding serine-type protease required for heterocyst differentiation in heterocystous cyanobacteria under conditions of nitrogen deprivation. Mutation of HetR from of Anabaena sp. (s...

[ "GO:0003677", "GO:0004252", "GO:0043158" ]

[ "DNA binding", "serine-type endopeptidase activity", "heterocyst development" ]

[ "molecular_function", "molecular_function", "biological_process" ]

3

[ "HAMAP", "NCBIFAM" ]

[ "MF_00781", "NF009718" ]

[ "HetR", "PRK13245.1" ]

[ 165, 216 ]

2

[ "EC", "METACYC" ]

[ "3.4.21.-", "PWY-7884" ]

[ "EC:3.4.21.-", "METACYC:PWY-7884" ]

2

[ "3qod", "3qoe", "4hri", "4izz", "4j00", "4j01", "4yrv" ]

7

[ "PUB00000522", "PUB00003576", "PUB00044662", "PUB00044663", "PUB00104871", "PUB00104872" ]

[ "8439290", "7845208", "10692362", "15051891", "15520378", "17220221" ]

[ "Evolutionary families of peptidases.", "Families of serine peptidases.", "Identification of the active site of HetR protease and its requirement for heterocyst differentiation in the cyanobacterium Anabaena sp. strain PCC 7120.", "HetR homodimer is a DNA-binding protein required for heterocyst differentiatio...

[ 1993, 1994, 2000, 2004, 2004, 2007 ]

6

[]

0

null

[ "Cyanobacteriota" ]

[ 216 ]

1

[]

0

true

Family

Peptidase S48, DNA-binding transcriptional activator HetR

Pept_S48_HetR

7

IPR005320

5,320

Peptidase S51

Peptidase_S51

Family

17,439

false

Proteolytic enzymes that exploit serine in their catalytic activity are ubiquitous, being found in viruses, bacteria and eukaryotes [ ]. They include a wide range of peptidase activity, including exopeptidase, endopeptidase, oligopeptidase and omega-peptidase activity. Many families of serine protease have been identif...

[ "GO:0008236", "GO:0006508" ]

[ "serine-type peptidase activity", "proteolysis" ]

[ "molecular_function", "biological_process" ]

2

[ "PFAM", "CDD" ]

[ "PF03575", "cd03146" ]

[ "Peptidase_S51", "GAT1_Peptidase_E" ]

[ 17432, 6871 ]

2

[ "EC" ]

[ "3.4.13.21" ]

[ "EC:3.4.13.21" ]

1

[ "1fy2", "1fye", "3en0", "3l4e", "6a4r", "6a4s", "6a4t", "6iru", "6nqc", "7c9b", "7ffp", "7uqv", "7uqw" ]

13

[ "PUB00000522", "PUB00003576", "PUB00011861" ]

[ "8439290", "7845208", "11106384" ]

[ "Evolutionary families of peptidases.", "Families of serine peptidases.", "The structure of aspartyl dipeptidase reveals a unique fold with a Ser-His-Glu catalytic triad." ]

[ 1993, 1994, 2000 ]

3

[]

[ "IPR011811", "IPR023172" ]

0

2

0

[ "Archaea", "Bacteria", "Eukaryota", "Myoviridae sp. ctQQg4", "unclassified sequences" ]

[ 11, 15513, 1634, 1, 280 ]

5

[ "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)" ]

[ 1, 2, 1 ]

3

true

Family

Peptidase S51

Peptidase_S51

4

IPR005321

5,321

Peptidase S58, DmpA

Peptidase_S58_DmpA

Family

13,256

false

This group of serine peptidases belong to MEROPS peptidase family S58 (DmpA aminopeptidase family, clan PE). The protein fold of the peptidase unit for members of this family resembles that of archaean proteasome subunit B, the type example of clan PB. The type example is aminopeptidase DmpA from Ochrobactrum anthropi....

[]

0

[ "PFAM", "PANTHER" ]

[ "PF03576", "PTHR36512" ]

[ "Peptidase_S58", "" ]

[ 13230, 13181 ]

2

[]

0

[ "1b65", "2drh", "3axg", "3n2w", "3n33", "3n5i", "3ndv", "3nfb", "3s3u", "3tm1", "3tm2", "4ihd", "4ihe", "5tzb", "5xyg", "5xyo", "5xyp", "5xyq", "5xys", "5xyt", "5y0l", "5y0m", "7yu0", "7yu1", "7yu2", "9cxr", "9dys" ]

27

[ "PUB00015067" ]

[ "10673442" ]

[ "A new variant of the Ntn hydrolase fold revealed by the crystal structure of L-aminopeptidase D-ala-esterase/amidase from Ochrobactrum anthropi." ]

[ 2000 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Megamimivirinae", "unclassified sequences" ]

[ 102, 11801, 1145, 16, 192 ]

5

[]

0

true

Family

Peptidase S58, DmpA

Peptidase_S58_DmpA

4

IPR005322

5,322

Peptidase C69

Peptidase_C69

Family

12,076

false

This group of peptidases, belong to MEROPS peptidase family C69 (dipeptidase, clan PB). They are mainly dipeptidases [ ] such as dipeptidase A from Lactobacillus helveticus (MEROPS identifier C69.001). This entry also include Secernin 1-3 from animals (MEROPS identifier C69.003) which may regulate exocytosis in mast ce...

[ "GO:0016805", "GO:0070004", "GO:0006508" ]

[ "dipeptidase activity", "cysteine-type exopeptidase activity", "proteolysis" ]

[ "molecular_function", "molecular_function", "biological_process" ]

3

[ "PFAM", "PANTHER" ]

[ "PF03577", "PTHR12994" ]

[ "Peptidase_C69", "" ]

[ 11188, 11834 ]

2

[]

0

[ "5iau", "5img", "5imh", "5inr", "5inx" ]

5

[ "PUB00011704", "PUB00011859", "PUB00020025", "PUB00020040", "PUB00030423", "PUB00076953", "PUB00151042", "PUB00151043" ]

[ "11517925", "8766699", "9891971", "12717035", "14725770", "7044372", "12221138", "31796108" ]

[ "Evolutionary lines of cysteine peptidases.", "Molecular characterization, over-expression and purification of a novel dipeptidase from Lactobacillus helveticus.", "Identification of the active site of legumain links it to caspases, clostripain and gingipains in a new clan of cysteine endopeptidases.", "Pepti...

[ 2001, 1996, 1998, 2003, 2004, 1982, 2002, 2019 ]

8

[]

[ "IPR047804" ]

0

1

0

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 94, 7120, 4690, 172 ]

4

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 5, 1, 24, 9, 12 ]

5

true

Family

Peptidase C69

Peptidase_C69

8

IPR005324

5,324

Small ribosomal subunit protein uS5, C-terminal

Ribosomal_uS5_C

Domain

37,315

false

This entry represents the C-terminal of the ribosomal protein uS5, which is related to the 30S ribosomal protein S5P from Sulfolobus acidocaldarius ( ). Ribosomal protein uS5 is one of the proteins from the small ribosomal subunit. In Escherichia coli, uS5 is known to be important in the assembly and function of the 30...

[ "GO:0003735", "GO:0006412", "GO:0005840" ]

[ "structural constituent of ribosome", "translation", "ribosome" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PFAM" ]

[ "PF03719" ]

[ "Ribosomal_S5_C" ]

[ 37315 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-5389840", "R-BTA-5419276", "R-BTA-9937383", "R-CEL-156827", "R-CEL-1799339", "R-CEL-5389840", "R-CEL-5419276", "R-CEL-6791226", "R-CEL-72649", "R-CEL-72689", "R-CEL-72695", "R-CEL-72702", "R-CEL-72706", "R-CEL-975956", "R-CEL-975957", "R-CEL-9937383", "R-DDI-156827", "R-DDI-...

[ "REACTOME:R-BTA-5389840", "REACTOME:R-BTA-5419276", "REACTOME:R-BTA-9937383", "REACTOME:R-CEL-156827", "REACTOME:R-CEL-1799339", "REACTOME:R-CEL-5389840", "REACTOME:R-CEL-5419276", "REACTOME:R-CEL-6791226", "REACTOME:R-CEL-72649", "REACTOME:R-CEL-72689", "REACTOME:R-CEL-72695", "REACTOME:R-CEL...

115

[ "1dv4", "1eg0", "1fjg", "1fka", "1hnw", "1hnx", "1hnz", "1hr0", "1i94", "1i95", "1i96", "1i97", "1ibk", "1ibl", "1ibm", "1j5e", "1jgo", "1jgp", "1jgq", "1ml5", "1n32", "1n33", "1n34", "1n36", "1pkp", "1qd7", "1vvj", "1vy4", "1vy5", "1vy6", "1vy7", "1xmo"...

1,865

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 944, 23613, 12254, 504 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus",...

[ 28, 2, 2, 3, 1, 19, 15, 2, 17, 32, 2, 2, 24 ]

13

true

Domain

Small ribosomal subunit protein uS5, C-terminal

Ribosomal_uS5_C

6

IPR005325

5,325

Protein of unknown function DUF308, membrane

DUF308_memb

Repeat

15,079

false

This represents a group of short repeats that occurs in a limited number of membrane proteins. It may divide further in short repeats of around 7-10 residues of the pattern G-#-X(2)-#(2)-X (#=hydrophobic) [ ].

[]

0

[ "PFAM" ]

[ "PF03729" ]

[ "DUF308" ]

[ 15079 ]

1

[]

0

[]

0

[ "PUB00016669" ]

[ "12625841" ]

[ "New knowledge from old: in silico discovery of novel protein domains in Streptomyces coelicolor." ]

[ 2003 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "metagenomes" ]

[ 511, 14368, 65, 135 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Repeat

Protein of unknown function DUF308, membrane

DUF308_memb

1

IPR005326

5,326

Plectin/eS10, N-terminal

Plectin_eS10_N

Domain

6,757

false

This domain is found at the N terminus of some isoforms of the cytoskeletal muscle protein plectin as well as the eukaryotic small ribosomal subunit protein eS10. This domain may be involved in RNA binding.

[]

0

[ "PFAM" ]

[ "PF03501" ]

[ "S10_plectin" ]

[ 6757 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-156827", "R-BTA-1799339", "R-BTA-6791226", "R-BTA-72649", "R-BTA-72689", "R-BTA-72695", "R-BTA-72702", "R-BTA-72706", "R-BTA-975956", "R-BTA-975957", "R-DDI-156827", "R-DDI-1799339", "R-DDI-72689", "R-DDI-72695", "R-DDI-72702", "R-DDI-72706", "R-DDI-975956", "R-DDI-975957", ...

[ "REACTOME:R-BTA-156827", "REACTOME:R-BTA-1799339", "REACTOME:R-BTA-6791226", "REACTOME:R-BTA-72649", "REACTOME:R-BTA-72689", "REACTOME:R-BTA-72695", "REACTOME:R-BTA-72702", "REACTOME:R-BTA-72706", "REACTOME:R-BTA-975956", "REACTOME:R-BTA-975957", "REACTOME:R-DDI-156827", "REACTOME:R-DDI-179933...

90

[ "3j6x", "3j6y", "3j77", "3j78", "3j7a", "3j7p", "3j7r", "3j80", "3j81", "3jag", "3jah", "3jai", "3jaj", "3jam", "3jan", "3jap", "3jbn", "3jbo", "3jbp", "4bts", "4d5l", "4d61", "4kzx", "4kzy", "4kzz", "4u3m", "4u3n", "4u3u", "4u4n", "4u4o", "4u4q", "4u4r"...

507

[]

0

[]

0

null

[ "Bacteria", "Eukaryota" ]

[ 4, 6753 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 13, 1, 14, 6, 10, 10, 1, 4, 14, 2, 2, 24 ]

12

true

Domain

Plectin/eS10, N-terminal

Plectin_eS10_N

6

IPR005327

5,327

Small hydrophobic protein

SHP

Family

313

false

The small hydrophobic integral membrane protein, SH (previously designated 1A) is found to have a variety of glycosylated forms [ , ]. This protein is a component of the mature respiratory syncytial virion [ ] where it may form complexes and appears to play a structural role.

[]

0

[ "PFAM" ]

[ "PF03579" ]

[ "SHP" ]

[ 313 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-9820960", "R-HSA-9820962", "R-HSA-9828721", "R-HSA-9828806", "R-HSA-9833110" ]

[ "REACTOME:R-HSA-9820960", "REACTOME:R-HSA-9820962", "REACTOME:R-HSA-9828721", "REACTOME:R-HSA-9828806", "REACTOME:R-HSA-9833110" ]

5

[ "2nb8" ]

1

[ "PUB00008398", "PUB00008399" ]

[ "1413513", "2374008" ]

[ "Polylactosaminoglycan modification of the respiratory syncytial virus small hydrophobic (SH) protein: a conserved feature among human and bovine respiratory syncytial viruses.", "The small hydrophobic protein of human respiratory syncytial virus: comparison between antigenic subgroups A and B." ]

[ 1992, 1990 ]

2

[]

0

null

[ "Orthopneumovirus" ]

[ 313 ]

1

[]

0

true

Family

Small hydrophobic protein

SHP

4

IPR005328

5,328

Sic protein repeat

Sic

Repeat

321

false

Serotype M1 group A Streptococcus strains cause epidemic waves of human infections. This 30 aa repeat occurs in the sic protein, an extracellular protein (streptococcal inhibitor of complement) that inhibits human complement [ ].

[]

0

[ "PFAM" ]

[ "PF03482" ]

[ "SIC" ]

[ 321 ]

1

[]

0

[]

0

[ "PUB00008400" ]

[ "10426317" ]

[ "Rapid selection of complement-inhibiting protein variants in group A Streptococcus epidemic waves." ]

[ 1999 ]

1

[]

0

null

[ "Streptococcus" ]

[ 321 ]

1

[]

0

true

Repeat

Sic protein repeat

Sic

1

IPR005330

5,330

MHYT domain

MHYT_dom

Domain

13,796

false

The MHYT domain is an about 190-residue domain, which was named after its conserved amino acid pattern. The MHYT domain consists of six predicted transmembrane (TM) segments, connected by short arginine-rich cytoplasmic loops and periplasmic loops that are also rich in charged amino acid residues. Three of its TM segme...

[]

0

[ "PFAM", "PROFILE" ]

[ "PF03707", "PS50924" ]

[ "MHYT", "MHYT" ]

[ 13493, 13398 ]

2

[ "PROSITEDOC" ]

[ "PDOC50924" ]

[ "PROSITEDOC:PDOC50924" ]

1

[]

0

[ "PUB00016193" ]

[ "11728710" ]

[ "MHYT, a new integral membrane sensor domain." ]

[ 2001 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 11910, 1848, 38 ]

3

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)" ]

[ 1 ]

1

true

Domain

MHYT domain

MHYT_dom

1

IPR005331

5,331

Sulfotransferase

Family

27,355

false

This entry consists of a number of carbohydrate sulphotransferases that transfer sulphate to carbohydrate groups in glycoproteins and glycolipids. These include: Carbohydrate sulphotransferases 8 and 9, which transfer sulphate to position 4 of non-reducing N-acetylgalactosamine (GalNAc) residues in both N-glycans and O...

[ "GO:0008146", "GO:0016020" ]

[ "sulfotransferase activity", "membrane" ]

[ "molecular_function", "cellular_component" ]

2

[ "PFAM" ]

[ "PF03567" ]

[ "Sulfotransfer_2" ]

[ 27355 ]

1

[ "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "2.8.2.-", "PWY-6546", "PWY-6558", "PWY-6567", "PWY-6568", "PWY-7831", "PWY-8045", "PWY-8358", "PWY-8381", "R-CEL-2022928", "R-DME-2022870", "R-DME-2022923", "R-DME-2022928", "R-DRE-2022870", "R-DRE-2022923", "R-DRE-2022928", "R-DRE-975578", "R-DRE-9939291", "R-GGA-2022928", "R...

[ "EC:2.8.2.-", "METACYC:PWY-6546", "METACYC:PWY-6558", "METACYC:PWY-6567", "METACYC:PWY-6568", "METACYC:PWY-7831", "METACYC:PWY-8045", "METACYC:PWY-8358", "METACYC:PWY-8381", "REACTOME:R-CEL-2022928", "REACTOME:R-DME-2022870", "REACTOME:R-DME-2022923", "REACTOME:R-DME-2022928", "REACTOME:R-...

33

[ "3f5f", "4ndz", "5t03", "5t05", "5t0a" ]

5

[ "PUB00010170", "PUB00012826", "PUB00033954", "PUB00033955", "PUB00033956", "PUB00033957", "PUB00053392", "PUB00085650" ]

[ "11956326", "12492399", "11445554", "9478973", "10781601", "11470797", "18697746", "27645998" ]

[ "Increased responsiveness of hypoxic endothelial cells to FGF2 is mediated by HIF-1alpha-dependent regulation of enzymes involved in synthesis of heparan sulfate FGF2-binding sites.", "Biosynthesis of heparan sulphate with diverse structures and functions: two alternatively spliced forms of human heparan sulphate...

[ 2002, 2003, 2001, 1998, 2000, 2001, 2008, 2016 ]

8

[]

[ "IPR007669", "IPR007734", "IPR010635", "IPR018011" ]

0

4

0

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "metagenomes" ]

[ 8, 4852, 22274, 51, 170 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 4, 32, 87, 10, 35, 27, 42 ]

7

true

Family

Sulfotransferase

5

IPR005332

5,332

Tomato bushy stunt virus (TBSV), p22, movement protein

TBSV_p22

Family

57

false

Two small nested genes (p19 and p22) are located near the 3' end of the genome of tomato bushy stunt virus (TBSV) -the p19 gene encodes a soluble protein, whereas the p22 gene specifies a membrane-associated protein. p22 is required for cell-to-cell movement in all plants tested [ ].

[ "GO:0019028" ]

[ "viral capsid" ]

[ "cellular_component" ]

1

[ "PFAM" ]

[ "PF03558" ]

[ "TBSV_P22" ]

[ 57 ]

1

[]

0

[]

0

[ "PUB00008401" ]

[ "7491767" ]

[ "Tomato bushy stunt virus spread is regulated by two nested genes that function in cell-to-cell movement and host-dependent systemic invasion." ]

[ 1995 ]

1

[]

0

null

[ "Orthornavirae" ]

[ 57 ]

1

[]

0

true

Family

Tomato bushy stunt virus (TBSV), p22, movement protein

TBSV_p22

3

IPR005333

5,333

Transcription factor, TCP

Transcription_factor_TCP

Family

14,913

false

The TCP transcription factor family was named after: teosinte branched 1 (tb1, Zea mays (Maize)) [ ], cycloidea (cyc) (Antirrhinum majus) (Garden snapdragon) [ ] and PCF in rice (Oryza sativa) [ , ]. The TCP proteins code for structurally related proteins implicated in the evolution of key morphological traits [ ]. How...

[ "GO:0003700" ]

[ "DNA-binding transcription factor activity" ]

[ "molecular_function" ]

1

[ "PANTHER" ]

[ "PTHR31072" ]

[ "" ]

[ 14913 ]

1

[]

0

[ "5zkt", "7vp1", "7vp2", "7vp3", "7vp4", "7vp5", "7vp6", "7vp7" ]

8

[ "PUB00008402", "PUB00036025", "PUB00036026", "PUB00036027", "PUB00036028", "PUB00036029" ]

[ "10363373", "17452340", "12000681", "539398", "16123132", "17568984" ]

[ "The TCP domain: a motif found in proteins regulating plant growth and development.", "Arabidopsis Teosinte Branched1-like 1 regulates axillary bud outgrowth and is homologous to monocot Teosinte Branched1.", "DNA binding and dimerization specificity and potential targets for the TCP protein family.", "Skin t...

[ 1999, 2007, 2002, 1979, 2005, 2007 ]

6

[]

0

null

[ "Streptophytina" ]

[ 14913 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 95, 62, 104 ]

3

true

Family

Transcription factor, TCP

Transcription_factor_TCP

7

IPR005334

5,334

Dynein light chain Tctex-1-like

Tctex-1-like

Family

11,610

false

Tctex-1 is a dynein light chain. Dynein translocates rhodopsin-bearing vesicles along microtubules and it has been shown that Tctex-1 can bind to the cytoplasmic tail of rhodopsin for retrograde or apical transport [ ]. An efficient vectorial transport system must be required to deliver large numbers of newly synthesis...

[]

0

[ "PFAM", "PANTHER" ]

[ "PF03645", "PTHR21255" ]

[ "Tctex-1", "" ]

[ 11608, 10829 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-DDI-6798695", "R-DME-6798695", "R-HSA-5620924", "R-HSA-6798695", "R-MMU-5620924", "R-MMU-6798695", "R-RNO-6798695", "R-SPO-6798695" ]

[ "REACTOME:R-DDI-6798695", "REACTOME:R-DME-6798695", "REACTOME:R-HSA-5620924", "REACTOME:R-HSA-6798695", "REACTOME:R-MMU-5620924", "REACTOME:R-MMU-6798695", "REACTOME:R-RNO-6798695", "REACTOME:R-SPO-6798695" ]

8

[ "1xdx", "1ygt", "2pg1", "3fm7", "5hxl", "5hyc", "5jpw", "5wi4", "6zyw", "6zyx", "7k58", "7k5b", "7kek", "7kzm", "7kzn", "7moq", "8bwy", "8bx8", "8glv", "8j07", "8pr0", "8pr1", "8ptk", "8rgi", "9bly", "9e12", "9e13", "9e14", "9e23", "9e28", "9e5c", "9fqr"...

32

[ "PUB00007752", "PUB00020416", "PUB00038504", "PUB00095613" ]

[ "2570638", "10399916", "15701632", "28706108" ]

[ "tctex-1: a candidate gene family for a mouse t complex sterility locus.", "Rhodopsin's carboxy-terminal cytoplasmic tail acts as a membrane receptor for cytoplasmic dynein by binding to the dynein light chain Tctex-1.", "Crystal structure of dynein light chain TcTex-1.", "Novel function of a dynein light cha...

[ 1989, 1999, 2005, 2017 ]

4

[]

0

null

[ "Eukaryota", "bird metagenome" ]

[ 11609, 1 ]

2

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 3, 9, 9, 11, 20, 1, 24, 1 ]

8

true

Family

Dynein light chain Tctex-1-like

Tctex-1-like

7

IPR005335

5,335

Terminase small subunit

Terminase_ssu

Family

5,685

false

Packaging of double-stranded viral DNA concatemers requires interaction of the prohead with virus DNA. This process is mediated by a phage-encoded DNA recognition and terminase protein. The terminase enzymes described so far, which are hetero-oligomers composed of a small and a large subunit, do not have a significant ...

[ "GO:0051276" ]

[ "chromosome organization" ]

[ "biological_process" ]

1

[ "PFAM" ]

[ "PF03592" ]

[ "Terminase_2" ]

[ 5685 ]

1

[ "GP" ]

[ "GenProp0208" ]

[ "GP:GenProp0208" ]

1

[ "2cmp", "3zqm", "3zqn", "3zqo", "3zqp", "3zqq", "4zc3" ]

7

[ "PUB00008403", "PUB00057578", "PUB00062503", "PUB00067159" ]

[ "2679356", "22207627", "22858866", "23545641" ]

[ "DNA packaging in dsDNA bacteriophages.", "Structural basis for DNA recognition and loading into a viral packaging motor.", "Structural and Functional Studies of the Phage Sf6 Terminase Small Subunit Reveal a DNA-Spooling Device Facilitated by Structural Plasticity.", "The 1.58 A resolution structure of the D...

[ 1989, 2012, 2012, 2013 ]

4

[]

0

null

[ "Bacteria", "Methanobacteriota", "Opisthokonta", "Viruses", "unclassified sequences" ]

[ 4914, 4, 5, 570, 192 ]

5

[]

0

true

Family

Terminase small subunit

Terminase_ssu

3

IPR005336

5,336

Mitochondrial pyruvate carrier

MPC

Family

10,173

false

This entry represents the mitochondrial pyruvate carrier proteins, including Mpc 1/2 and their homologues. They mediate the uptake of pyruvate into mitochondria [ ]. In humans, Mpc1 and Mpc2 associate to form an ~150-kilodalton complex in the inner mitochondrial membrane [ ].

[ "GO:0006850", "GO:0005743" ]

[ "pyruvate import into mitochondria", "mitochondrial inner membrane" ]

[ "biological_process", "cellular_component" ]

2

[ "PFAM" ]

[ "PF03650" ]

[ "MPC" ]

[ 10173 ]

1

[ "REACTOME" ]

[ "R-HSA-70268" ]

[ "REACTOME:R-HSA-70268" ]

1

[ "8yw6", "8yw8", "8yw9", "9giv", "9giw", "9gix", "9giy", "9knw", "9knx", "9kny", "9mnw", "9mnx", "9mny", "9mnz", "9mo0", "9o9s", "9o9t" ]

17

[ "PUB00066748" ]

[ "22628558" ]

[ "A mitochondrial pyruvate carrier required for pyruvate uptake in yeast, Drosophila, and humans." ]

[ 2012 ]

1

[]

0

null

[ "Eukaryota" ]

[ 10173 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 12, 2, 6, 7, 6, 10, 3, 13, 12, 3, 2, 22 ]

12

true

Family

Mitochondrial pyruvate carrier

MPC

9

IPR005337

5,337

RapZ-like family

RapZ-like

Family

19,238

false

This entry represents RNase adapter protein RapZ from Escherichia coli and similar bacterial proteins. RapZ plays a central role in RNA-mediated regulation of amino-sugar metabolism. It is a RNA-binding protein that recruits the major endoribonuclease RNase E to sRNAs GlmZ [ ]. Bacterial small RNAs (sRNAs) regulate div...

[ "GO:0005524" ]

[ "ATP binding" ]

[ "molecular_function" ]

1

[ "HAMAP", "NCBIFAM", "PIRSF", "PANTHER" ]

[ "MF_00636", "NF003828", "PIRSF005052", "PTHR30448" ]

[ "RapZ_like", "PRK05416.1", "P-loopkin", "" ]

[ 17599, 17704, 17341, 19230 ]

4

[]

0

[ "5o5o", "5o5q", "5o5s", "8b0i", "8b0j", "9m1q", "9m1v" ]

7

[ "PUB00075613", "PUB00075614", "PUB00150969" ]

[ "23475961", "19074378", "28977623" ]

[ "Targeted decay of a regulatory small RNA by an adaptor protein for RNase E and counteraction by an anti-adaptor RNA.", "Characterization of YvcJ, a conserved P-loop-containing protein, and its implication in competence in Bacillus subtilis.", "Structural insights into RapZ-mediated regulation of bacterial amin...

[ 2013, 2009, 2017 ]

3

[]

0

null

[ "Bacteria", "Caudoviricetes", "Eukaryota", "unclassified sequences" ]

[ 18723, 17, 92, 406 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

RapZ-like family

RapZ-like

5

IPR005338

5,338

Anhydro-N-acetylmuramic acid kinase

Anhydro_N_Ac-Mur_kinase

Family

15,735

false

This entry represents the enzyme Anhydro-N-acetylmuramic acid kinase, predominantly found in bacteria. This protein catalyses the specific phosphorylation of 1,6-anhydro-N-acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. It is also required for the utilisatio...

[ "GO:0005524", "GO:0016773", "GO:0006040", "GO:0009254" ]

[ "ATP binding", "phosphotransferase activity, alcohol group as acceptor", "amino sugar metabolic process", "peptidoglycan turnover" ]

[ "molecular_function", "molecular_function", "biological_process", "biological_process" ]

4

[ "HAMAP", "PFAM", "PANTHER" ]

[ "MF_01270", "PF03702", "PTHR30605" ]

[ "AnhMurNAc_kinase", "AnmK", "" ]

[ 12131, 15724, 15646 ]

3

[ "EC", "GP", "GP", "METACYC" ]

[ "2.7.1.170", "GenProp0766", "GenProp1623", "PWY-7883" ]

[ "EC:2.7.1.170", "GP:GenProp0766", "GP:GenProp1623", "METACYC:PWY-7883" ]

4

[ "3cqy", "3qbw", "3qbx", "4bg8", "4bg9", "4bga", "4bgb", "4mo4", "4mo5", "4yh5", "4zfv", "4zlu", "4zxz", "5bsb", "5bvc", "5tkr", "8bre", "8c0u", "8cp9", "8cpb" ]

20

[ "PUB00043013", "PUB00046146", "PUB00100277", "PUB00100278" ]

[ "16452451", "15901686", "26354439", "21719279" ]

[ "MurQ Etherase is required by Escherichia coli in order to metabolize anhydro-N-acetylmuramic acid obtained either from the environment or from its own cell wall.", "Recycling of the anhydro-N-acetylmuramic acid derived from cell wall murein involves a two-step conversion to N-acetylglucosamine-phosphate.", "Pr...

[ 2006, 2005, 2015, 2011 ]

4

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Myoviridae sp. ctHIt1", "unclassified sequences" ]

[ 23, 14206, 1292, 1, 213 ]

5

[ "Escherichia coli (strain K12)", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)" ]

[ 1, 2 ]

2

true

Family

Anhydro-N-acetylmuramic acid kinase

Anhydro_N_Ac-Mur_kinase

2

IPR005339

5,339

GINS complex, subunit Psf1

GINS_Psf1

Family

4,484

false

DNA replication in eukaryotes results from a highly coordinated interaction between proteins, often as part of protein complexes, and the DNA template. One of the key early steps leading to DNA replication is formation of the prereplication complex, or pre-RC. The pre-RC is formed by the sequential binding of the origi...

[ "GO:0006260", "GO:0000811" ]

[ "DNA replication", "GINS complex" ]

[ "biological_process", "cellular_component" ]

2

[ "PANTHER", "CDD" ]

[ "PTHR12914", "cd11710" ]

[ "", "GINS_A_psf1" ]

[ 4395, 4141 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-176974", "R-CEL-176974", "R-DDI-176974", "R-HSA-176974", "R-MMU-176974", "R-SCE-176974", "R-SPO-176974" ]

[ "REACTOME:R-BTA-176974", "REACTOME:R-CEL-176974", "REACTOME:R-DDI-176974", "REACTOME:R-HSA-176974", "REACTOME:R-MMU-176974", "REACTOME:R-SCE-176974", "REACTOME:R-SPO-176974" ]

7

[ "2e9x", "2eho", "2q9q", "3jc5", "3jc6", "3jc7", "5u8s", "5u8t", "6hv9", "6ptj", "6ptn", "6pto", "6raw", "6rax", "6ray", "6raz", "6skl", "6u0m", "6xtx", "6xty", "7pfo", "7plo", "7pmk", "7pmn", "7qhs", "7z13", "8b9a", "8b9b", "8b9c", "8b9d", "8kg6", "8kg8"...

46

[ "PUB00012381", "PUB00015004", "PUB00015005" ]

[ "12730133", "12730134", "8001157" ]

[ "A novel ring-like complex of Xenopus proteins essential for the initiation of DNA replication.", "GINS, a novel multiprotein complex required for chromosomal DNA replication in budding yeast.", "Crystal structure of the eukaryotic DNA polymerase processivity factor PCNA." ]

[ 2003, 2003, 1994 ]

3

[]

0

null

[ "Eukaryota" ]

[ 4484 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 5, 1, 1, 1, 15, 3, 1, 3, 4, 1, 1, 6 ]

12

true

Family

GINS complex, subunit Psf1

GINS_Psf1

8

IPR005341

5,341

Mitochondrial import inner membrane translocase subunit Tim16

Tim16

Family

4,529

false

This entry represents the mitochondrial import inner membrane translocase subunit Tim16 (also known as Pam16).

[ "GO:0030150", "GO:0005744" ]

[ "protein import into mitochondrial matrix", "TIM23 mitochondrial import inner membrane translocase complex" ]

[ "biological_process", "cellular_component" ]

2

[ "PANTHER" ]

[ "PTHR12388" ]

[ "" ]

[ 4529 ]

1

[ "REACTOME" ]

[ "R-HSA-1268020" ]

[ "REACTOME:R-HSA-1268020" ]

1

[ "2guz" ]

1

[ "PUB00019986" ]

[ "14981507" ]

[ "Pam16 has an essential role in the mitochondrial protein import motor." ]

[ 2004 ]

1

[]

0

null

[ "Eukaryota" ]

[ 4529 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 9, 1, 2, 5, 4, 2, 1, 5, 8, 1, 1, 5 ]

12

true

Family

Mitochondrial import inner membrane translocase subunit Tim16

Tim16

4

IPR005343

5,343

Nucleolar complex protein 2

Noc2

Family

6,644

false

In Saccharomyces cerevisiae, Nucleolar complex protein 2 (Noc2) forms a nucleolar complex with Mak21 that binds to 90S and 66S pre-ribosomes. It also forms a nuclear complex with Noc3 that binds to 66S pre-ribosomes [ ]. Both complexes mediate intranuclear transport of ribosomal precursors [ ]. In humans, Noc2 (also kn...

[]

0

[ "PFAM", "PANTHER" ]

[ "PF03715", "PTHR12687" ]

[ "Noc2", "" ]

[ 6448, 6587 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-6804756", "R-DME-6804756", "R-HSA-6804756", "R-MMU-6804756" ]

[ "REACTOME:R-BTA-6804756", "REACTOME:R-DME-6804756", "REACTOME:R-HSA-6804756", "REACTOME:R-MMU-6804756" ]

4

[ "7nac", "7nad", "7r6k", "7r72", "7r7a", "8e5t", "8esq", "8esr", "8fkv", "8fkw", "8fkx", "8fky", "8i9v", "8i9w", "8i9x", "8i9y", "8i9z", "8ia0", "8v87" ]

19

[ "PUB00020526", "PUB00063056", "PUB00063057", "PUB00063058", "PUB00090619", "PUB00100279" ]

[ "11371346", "16322561", "20123734", "20959462", "19734265", "18441215" ]

[ "Maturation and intranuclear transport of pre-ribosomes requires Noc proteins.", "NIR is a novel INHAT repressor that modulates the transcriptional activity of p53.", "NIR, an inhibitor of histone acetyltransferases, regulates transcription factor TAp63 and is controlled by the cell cycle.", "Aurora B interac...

[ 2001, 2005, 2010, 2011, 2009, 2008 ]

6

[]

0

null

[ "Eukaryota" ]

[ 6644 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 8, 1, 2, 1, 6, 4, 1, 4, 3, 1, 2, 57 ]

12

true

Family

Nucleolar complex protein 2

Noc2

1

IPR005344

5,344

TMEM33/Pom33 family

TMEM33/Pom33

Family

5,147

false

This entry represents the TMEM33/Pom33 family. Budding yeast Pom33 is a transmembrane nucleoporin that contributes to proper distribution and/or efficient assembly of nuclear pores [ ]. Proteins in this entry also include Tts1 from fission yeasts [ ], Kr-h2 (krueppel homologue 2) from flies [ ] and TMEM33 from vertebra...

[ "GO:0016020" ]

[ "membrane" ]

[ "cellular_component" ]

1

[ "PFAM" ]

[ "PF03661" ]

[ "TMEM33_Pom33" ]

[ 5147 ]

1

[]

0

[]

0

[ "PUB00075311", "PUB00075313", "PUB00075314", "PUB00085045", "PUB00094350" ]

[ "20498018", "20434336", "10816971", "25612671", "26268696" ]

[ "Pom33, a novel transmembrane nucleoporin required for proper nuclear pore complex distribution.", "The cortical ER network limits the permissive zone for actomyosin ring assembly.", "Kruppel homolog (Kr h) is a dosage-dependent modifier of gene expression in Drosophila.", "Identification and characterization...

[ 2010, 2010, 2000, 2014, 2015 ]

5

[]

0

null

[ "Eukaryota" ]

[ 5147 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 5, 4, 1, 2, 6, 7, 1, 10, 6, 2, 1, 15 ]

12

true

Family

TMEM33/Pom33 family

TMEM33/Pom33

3

IPR005345

5,345

PHF5-like

PHF5

Family

4,156

false

Phf5 is a member of a novel murine multigene family that is highly conserved during evolution and belongs to the superfamily of PHD-finger proteins. At least one example, from Mus musculus (mouse), may act as a chromatin-associated protein [ ]. The Schizosaccharomyces pombe (fission yeast) ini1 gene is essential, requi...

[ "GO:0000398" ]

[ "mRNA splicing, via spliceosome" ]

[ "biological_process" ]

1

[ "PFAM", "PIRSF", "PANTHER" ]

[ "PF03660", "PIRSF016468", "PTHR13120" ]

[ "PHF5", "PHF5", "" ]

[ 4156, 3290, 4065 ]

3

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-DME-72163", "R-HSA-72163", "R-MMU-72163", "R-RNO-72163", "R-SPO-72163" ]

[ "REACTOME:R-DME-72163", "REACTOME:R-HSA-72163", "REACTOME:R-MMU-72163", "REACTOME:R-RNO-72163", "REACTOME:R-SPO-72163" ]

5

[ "2k0a", "5gm6", "5ife", "5lqw", "5nrl", "5o9z", "5syb", "5z56", "5z57", "5z58", "5zwm", "5zwo", "5zya", "6ah0", "6ahd", "6en4", "6ff4", "6ff7", "6g90", "6qx9", "6y50", "6y5q", "7abg", "7abh", "7abi", "7b0i", "7b91", "7b92", "7b9c", "7dco", "7dvq", "7evn"...

69

[ "PUB00020105", "PUB00020106" ]

[ "12054543", "14762117" ]

[ "Identification and characterization of a novel murine multigene family containing a PHD-finger-like motif.", "A novel RING-finger-like protein Ini1 is essential for cell cycle progression in fission yeast." ]

[ 2002, 2004 ]

2

[]

0

null

[ "Eukaryota" ]

[ 4156 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 3, 1, 2, 2, 1, 1, 1, 5, 4, 1, 1, 5 ]

12

true

Family

PHF5-like

PHF5

4

IPR005346

5,346

RnfH protein

RnfH

Family

6,639

false

The RnfH family is a member of the ubiquitin superfamily. Members of the RnfH family strongly co-occur in two distinct gene neighbourhood contexts. In one it is associated with a START domain protein, a membrane protein SmpA and the transfer mRNA binding protein SmpB. This association suggests a possible role in the Sm...

[]

0

[ "HAMAP", "PFAM", "PANTHER" ]

[ "MF_00460", "PF03658", "PTHR37483" ]

[ "UPF0125_RnfH", "Ub-RnfH", "" ]

[ 6469, 6638, 6521 ]

3

[]

0

[ "2hj1", "8ahx", "8rb8", "8rb9", "8rbq" ]

5

[ "PUB00034476" ]

[ "16859499" ]

[ "The prokaryotic antecedents of the ubiquitin-signaling system and the early evolution of ubiquitin-like beta-grasp domains." ]

[ 2006 ]

1

[]

0

null

[ "Bacteria", "Escherichia phage vB_EcoM-613R3", "Opisthokonta", "unclassified sequences" ]

[ 6542, 1, 8, 88 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

RnfH protein

RnfH

8

IPR005349

5,349

TMEM14 family

TMEM14

Family

9,156

false

This entry includes a group of transmembrane proteins, including protein FATTY ACID EXPORT 1 (FAX1) from Arabidopsis and TMEM14 from animals. FAX1 mediates the export of free fatty acid from the plastids and is required for biogenesis of the outer pollen cell wall, in particular for the assembly of exine and pollen coa...

[ "GO:0016020" ]

[ "membrane" ]

[ "cellular_component" ]

1

[ "PFAM", "PANTHER" ]

[ "PF03647", "PTHR12668" ]

[ "Tmemb_14", "" ]

[ 9147, 8109 ]

2

[]

0

[ "2loo", "2lop", "2los" ]

3

[ "PUB00061006", "PUB00077562", "PUB00077563" ]

[ "22609626", "25646734", "19656490" ]

[ "Facile backbone structure determination of human membrane proteins by NMR spectroscopy.", "FAX1, a novel membrane protein mediating plastid fatty acid export.", "Discovery of genes essential for heme biosynthesis through large-scale gene expression analysis." ]

[ 2012, 2015, 2009 ]

3

[]

0

null

[ "Bacteria", "Eukaryota" ]

[ 237, 8919 ]

2

[ "Arabidopsis thaliana", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "...

[ 22, 10, 2, 13, 5, 1, 20, 8, 1, 1, 72 ]

11

true

Family

TMEM14 family

TMEM14

8

IPR005350

5,350

Uncharacterised protein family UPF0137

UPF0137

Family

80

false

This family of proteins mainly found in Chlamydiae includes a number of plasmid-encoded virulence proteins, such as Virulence plasmid protein pGP6-D from Chlamydia trachomatis, which seems to be required for growth within mammalian cells [ ].

[]

0

[ "PFAM" ]

[ "PF03677" ]

[ "UPF0137" ]

[ 80 ]

1

[]

0

[]

0

[ "PUB00011294" ]

[ "2845228" ]

[ "The structure of a plasmid of Chlamydia trachomatis believed to be required for growth within mammalian cells." ]

[ 1988 ]

1

[]

0

null

[ "Bacteria", "Dictyostelium firmibasis" ]

[ 78, 2 ]

2

[]

0

true

Family

Uncharacterised protein family UPF0137

UPF0137

5

IPR005352

5,352

Erg28

Family

3,804

false

This is a family of integral membrane proteins, which may contain four transmembrane helices. Members of this family are thought to be involved in sterol C-4 demethylation. In Saccharomyces cerevisiae (Baker's yeast) they may tether Erg26p (sterol dehydrogenase/decarboxylase) and Erg27p (3-ketoreductase) to the endopla...

[ "GO:0016020" ]

[ "membrane" ]

[ "cellular_component" ]

1

[ "PFAM", "PANTHER" ]

[ "PF03694", "PTHR15451" ]

[ "Erg28", "" ]

[ 3802, 3649 ]

2

[]

0

[]

0

[ "PUB00019518" ]

[ "11160377" ]

[ "A novel gene conserved from yeast to humans is involved in sterol biosynthesis." ]

[ 2001 ]

1

[]

0

null

[ "Eukaryota" ]

[ 3804 ]

1

[ "Arabidopsis thaliana", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "...

[ 3, 2, 1, 3, 2, 1, 2, 4, 1, 1, 19 ]

11

true

Family

Erg28

3

IPR005353

5,353

Uncharacterised protein family UPF0146

UPF0146

Family

545

false

This family consists of functionally uncharacterised proteins predominantly found in archaea, including from Methanothermobacter thermautotrophicus, which shows an α/β structure.

[]

0

[ "HAMAP", "PFAM", "PIRSF" ]

[ "MF_00341", "PF03686", "PIRSF016725" ]

[ "UPF0146", "UPF0146", "UCP016725" ]

[ 445, 545, 222 ]

3

[]

0

[ "2k4m" ]

1

[]

0

[]

0

null

[ "Archaea", "ecological metagenomes" ]

[ 540, 5 ]

2

[]

0

true

Family

Uncharacterised protein family UPF0146

UPF0146

6

IPR005354

5,354

Uncharacterised protein family UPF0147

UPF0147

Family

577

false

This family represents a group of proteins predominantly found in archaea, including UPF0147 protein Ta0600 from Thermoplasma acidophilum , which shows an all-α structure. Members of this entry are functionally uncharacterised.

[]

0

[ "HAMAP", "NCBIFAM", "PFAM" ]

[ "MF_00342", "NF003319", "PF03685" ]

[ "UPF0147", "PRK04330.1", "UPF0147" ]

[ 505, 511, 577 ]

3

[]

0

[ "2qsb", "2qzg" ]

2

[]

0

[]

0

null

[ "Archaea", "Eukaryota", "ecological metagenomes" ]

[ 531, 2, 44 ]

3

[]

0

true

Family

Uncharacterised protein family UPF0147

UPF0147

1

IPR005358

5,358

Putative zinc- or iron-chelating domain containing protein

Puta_zinc/iron-chelating_dom

Family

29,392

false

This family of proteins contains 8 conserved cysteines. It has in the past been annotated as being one of the complex of proteins of the flagellar Fli complex. However this was due to a mis-annotation of the original Salmonella LT2 Genbank entry of 'fliB'. With all its conserved cysteines it is possibly a domain that c...

[]

0

[ "PFAM" ]

[ "PF03692" ]

[ "CxxCxxCC" ]

[ 29392 ]

1

[]

0

[]

0

[ "PUB00066745", "PUB00066746" ]

[ "9168604", "15687208" ]

[ "The flagellin N-methylase gene fliB and an adjacent serovar-specific IS200 element in Salmonella typhimurium.", "The Flag-2 locus, an ancestral gene cluster, is potentially associated with a novel flagellar system from Escherichia coli." ]

[ 1997, 2005 ]

2

[]

[ "IPR008228", "IPR016928" ]

0

2

0

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 1409, 26794, 670, 19, 500 ]

5

[ "Arabidopsis thaliana", "Escherichia coli (strain K12)", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 3, 3, 5, 2 ]

4

true

Family

Putative zinc- or iron-chelating domain containing protein

Puta_zinc/iron-chelating_dom

2

IPR005359

5,359

Protein with unknown function UPF0154

UPF0154

Family

3,092

false

This entry includes a group of bacterial proteins that are functionally uncharacterised.

[]

0

[ "HAMAP", "PFAM" ]

[ "MF_00363", "PF03672" ]

[ "UPF0154", "UPF0154" ]

[ 1990, 3092 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Glomeromycetes", "metagenomes" ]

[ 3084, 4, 4 ]

3

[]

0

true

Family

Protein with unknown function UPF0154

UPF0154

8

IPR005361

5,361

Uncharacterised protein family UPF0158

UPF0158

Family

1,411

false

This is a small family of hypothetical bacterial proteins of unknown function.

[]

0

[ "PFAM" ]

[ "PF03682" ]

[ "UPF0158" ]

[ 1411 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Methanobacteriota", "ecological metagenomes" ]

[ 1388, 6, 17 ]

3

[]

0

true

Family

Uncharacterised protein family UPF0158

UPF0158

3

IPR005362

5,362

Uncharacterised protein family UPF0164

UPF0164

Family

384

false

This family of uncharacterised proteins were first identified in the proteome of Treponema pallidum where they are assumed to be secreted proteins because of the presence of putative signal peptides. Homologues are known from other spirochaetes, Elusimicrobia and other bacteria.

[]

0

[ "PFAM" ]

[ "PF03687" ]

[ "UPF0164" ]

[ 384 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "ecological metagenomes" ]

[ 359, 25 ]

2

[]

0

true

Family

Uncharacterised protein family UPF0164

UPF0164

3

IPR005363

5,363

Uncharacterised protein family UPF0167

UPF0167

Family

1,074

false

The proteins in this family are about 200 amino acids long and each contain 3 CXXC motifs.

[]

0

[ "PFAM" ]

[ "PF03691" ]

[ "UPF0167" ]

[ 1074 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota" ]

[ 1068, 6 ]

2

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Uncharacterised protein family UPF0167

UPF0167

4

IPR005365

5,365

Nitrogen permease regulator 3

Npr3

Family

4,262

false

In budding yeasts, Npr3 forms a complex with NPR2. This complex heterodimer is responsible for inactivating TORC1, an evolutionarily conserved protein complex that controls cell size via nutritional input signals, specifically, in response to amino acid starvation [ ]. In fission yeast, Nitrogen permease regulator 3-li...

[ "GO:0032007" ]

[ "negative regulation of TOR signaling" ]

[ "biological_process" ]

1

[ "PFAM", "PANTHER" ]

[ "PF03666", "PTHR13153" ]

[ "NPR3", "" ]

[ 4029, 4214 ]

2

[ "GP", "REACTOME", "REACTOME" ]

[ "GenProp2028", "R-HSA-9639288", "R-MMU-9639288" ]

[ "GP:GenProp2028", "REACTOME:R-HSA-9639288", "REACTOME:R-MMU-9639288" ]

3

[ "6ces", "6cet", "7t3a", "7t3b", "7t3c", "8adl", "8ae6", "8fw5", "9h4q", "9h5k", "9v0j" ]

11

[ "PUB00053872", "PUB00085662", "PUB00098636", "PUB00151526" ]

[ "19521502", "23723238", "33534698", "35338845" ]

[ "A genome-wide screen for regulators of TORC1 in response to amino acid starvation reveals a conserved Npr2/3 complex.", "A Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1.", "Tripartite suppression of fission yeast TORC1 signaling by the GATOR1-Sea3 c...

[ 2009, 2013, 2021, 2022 ]

4

[]

0

null

[ "Eukaryota" ]

[ 4262 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strai...

[ 2, 15, 2, 10, 6, 1, 4, 1, 1 ]

9

true

Family

Nitrogen permease regulator 3

Npr3

4

IPR005366

5,366

ER membrane protein complex subunit 8/9

EMC8/9

Family

3,821

false

Saccharomyces cerevisiae ER membrane protein complex (EMC) comprises six subunits [ ]. Four and three additional subunits have been identified in mammals and Drosophila, respectively [ ]. EMC is required for protein folding in the endoplasmic reticulum (ER). It also facilitates lipid transfer from ER to mitochondria [ ...

[ "GO:0072546" ]

[ "EMC complex" ]

[ "cellular_component" ]

1

[ "PFAM", "PANTHER", "CDD" ]

[ "PF03665", "PTHR12941", "cd08060" ]

[ "UPF0172", "", "MPN_UPF0172" ]

[ 3820, 3669, 3230 ]

3

[]

0

[ "6ww7", "6y4l", "6z3w", "7ado", "7adp", "8eoi", "8j0n", "8j0o", "8s9s", "9c7v" ]

10

[ "PUB00061987", "PUB00070552", "PUB00080899", "PUB00080901", "PUB00080902" ]

[ "19325107", "22119785", "25313861", "10337626", "25715730" ]

[ "Comprehensive characterization of genes required for protein folding in the endoplasmic reticulum.", "Defining human ERAD networks through an integrative mapping strategy.", "A conserved endoplasmic reticulum membrane protein complex (EMC) facilitates phospholipid transfer from the ER to mitochondria.", "The...

[ 2009, 2012, 2014, 1999, 2015 ]

5

[]

0

null

[ "Eukaryota", "marine sediment metagenome" ]

[ 3820, 1 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 11, 1, 2, 2, 7, 13, 2, 5, 3 ]

9

true

Family

ER membrane protein complex subunit 8/9

EMC8/9

8

IPR005368

5,368

UPF0175

Family

3,798

false

This entry contains small proteins of unknown function, they belong to the UPF0175 group and are mainly found in prokaryotes.

[]

0

[ "PFAM", "PANTHER" ]

[ "PF03683", "PTHR37525" ]

[ "UPF0175", "" ]

[ 3787, 1303 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 794, 2913, 2, 89 ]

4

[]

0

true

Family

UPF0175

3

IPR005369

5,369

Uncharacterised protein family UPF0179

UPF0179

Family

703

false

The function of this family is unknown, however the proteins contain two cysteine clusters that may be iron sulphur redox centres.

[]

0

[ "HAMAP", "PFAM", "PIRSF", "PANTHER" ]

[ "MF_00498", "PF03684", "PIRSF006595", "PTHR40699" ]

[ "UPF0179", "UPF0179", "UCP006595", "" ]

[ 682, 703, 528, 701 ]

4

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "candidate division WOR-3 bacterium", "unclassified sequences" ]

[ 689, 1, 13 ]

3

[]

0

true

Family

Uncharacterised protein family UPF0179

UPF0179

2

IPR005370

5,370

Uncharacterised protein family UPF0180

UPF0180

Family

1,455

false

The members of this family are small uncharacterised proteins.

[]

0

[ "HAMAP", "PFAM" ]

[ "MF_00506", "PF03698" ]

[ "UPF0180", "UPF0180" ]

[ 657, 1455 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Bacillati", "Rhizophagus irregularis", "ecological metagenomes" ]

[ 1443, 1, 11 ]

3

[]

0

true

Family

Uncharacterised protein family UPF0180

UPF0180

9

IPR005371

5,371

Uncharacterised protein family UPF0181

UPF0181

Family

1,488

false

This family contains small proteins of about 50 amino acids of unknown function. The family includes YoaH ( ).

[]

0

[ "HAMAP", "NCBIFAM", "PFAM" ]

[ "MF_00507", "NF003476", "PF03701" ]

[ "UPF0181", "PRK05114.1", "UPF0181" ]

[ 1264, 1446, 1488 ]

3

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Beauveria bassiana D1-5" ]

[ 1487, 1 ]

2

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Uncharacterised protein family UPF0181

UPF0181

9

IPR005372

5,372

Uncharacterised protein family UPF0182

UPF0182

Family

6,904

false

This family contains uncharacterised integral membrane proteins.

[ "GO:0016020" ]

[ "membrane" ]

[ "cellular_component" ]

1

[ "HAMAP", "PFAM", "PANTHER" ]

[ "MF_01600", "PF03699", "PTHR39344" ]

[ "UPF0182", "UPF0182", "" ]

[ 6049, 6856, 6880 ]

3

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 160, 6322, 11, 411 ]

4

[]

0

true

Family

Uncharacterised protein family UPF0182

UPF0182

6

IPR005373

5,373

Phagosome assembly factor 1

PHAF1

Family

4,693

false

PHAF1 and BCAS3 form a complex that affects the recruitment of several core autophagy proteins to the phagophore assembly site [ ].

[]

0

[ "PFAM" ]

[ "PF03676" ]

[ "PHAF1" ]

[ 4693 ]

1

[]

0

[]

0

[ "PUB00097858" ]

[ "33499712" ]

[ "Mammalian BCAS3 and C16orf70 associate with the phagophore assembly site in response to selective and non-selective autophagy." ]

[ 2021 ]

1

[ "IPR039156" ]

[]

1

0

1

[ "Eukaryota" ]

[ 4693 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 2, 1, 2, 1, 5, 5, 1, 3, 5, 5 ]

10

true

Family

Phagosome assembly factor 1

PHAF1

9

IPR005374

5,374

Bublin coiled-coil protein-like, eukaryota

BBLN_eukaryota

Family

829

false

This small family includes Bublin coiled-coil proteins (BBLNs) found in eukaryotes (also known UPF0184 proteins), including the human BBLN previously known as UPF0184 protein C9orf16 and other uncharacterised proteins. Their function is currently unknown.

[]

0

[ "PANTHER" ]

[ "PTHR34344" ]

[ "" ]

[ 829 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Calothrix parasitica NIES-267", "Metazoa" ]

[ 1, 828 ]

2

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus" ]

[ 2, 2, 2, 1 ]

4

true

Family

Bublin coiled-coil protein-like, eukaryota

BBLN_eukaryota

1

IPR005375

5,375

Ubiquitin-fold modifier 1

UFM1

Family

2,210

false

This entry represents Ufm1 (ubiquitin-fold modifier), which is a ubiquitin-like protein with structural similarities to ubiquitin [ , ]. Ufm1 is one of a number of ubiquitin-like modifiers that conjugate to target proteins in cells through Uba5 (E1) and Ufc1 (E2). The Ufm1-system is conserved in metazoa and plants, sug...

[ "GO:0071569" ]

[ "protein ufmylation" ]

[ "biological_process" ]

1

[ "PFAM", "PIRSF", "PANTHER" ]

[ "PF03671", "PIRSF038027", "PTHR15825" ]

[ "Ufm1", "Ubiquitin-like_Ufm1", "" ]

[ 2207, 1149, 2131 ]

3

[]

0

[ "1j0g", "1l7y", "1wxs", "5hkh", "5ia7", "5ia8", "5iaa", "5l95", "5xda", "6h77", "6izg", "7w3n", "8bzr", "8ohd", "8oj0", "8oj5", "8qfc", "9gy4" ]

18

[ "PUB00034737", "PUB00034738", "PUB00034739", "PUB00034740" ]

[ "10884686", "16527251", "17182609", "15071506" ]

[ "Ubiquitin and its kin: how close are the family ties?", "Solution structure and dynamics of Ufm1, a ubiquitin-fold modifier 1.", "Two novel ubiquitin-fold modifier 1 (Ufm1)-specific proteases, UfSP1 and UfSP2.", "A novel protein-conjugating system for Ufm1, a ubiquitin-fold modifier." ]

[ 2000, 2006, 2007, 2004 ]

4

[]

0

null

[ "Eukaryota" ]

[ 2210 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 2, 1, 2, 2, 2, 3, 2, 1, 5 ]

9

true

Family

Ubiquitin-fold modifier 1

UFM1

2

IPR005376

5,376

Adenovirus DNA-binding, zinc-binding domain

Adenovirus_DNA-bd_zn-bd

Domain

490

false

The adenovirus early E2A DNA-binding protein (Ad DBP) is a multifunctional protein required, amongst other things, for DNA replication and transcription control. It binds to single- and double-stranded DNA, as well as to RNA, in a sequence-independent manner. This signature represents the zinc binding domain of the vir...

[ "GO:0003677", "GO:0008270", "GO:0006260" ]

[ "DNA binding", "zinc ion binding", "DNA replication" ]

[ "molecular_function", "molecular_function", "biological_process" ]

3

[ "PFAM" ]

[ "PF03728" ]

[ "Viral_DNA_Zn_bi" ]

[ 490 ]

1

[]

0

[ "1adu", "1adv", "1anv", "2waz", "2wb0" ]

5

[ "PUB00007753" ]

[ "8039495" ]

[ "Crystal structure of the adenovirus DNA binding protein reveals a hook-on model for cooperative DNA binding." ]

[ 1994 ]

1

[]

0

null

[ "Adenoviridae", "Streptomyces sioyaensis" ]

[ 489, 1 ]

2

[]

0

true

Domain

Adenovirus DNA-binding, zinc-binding domain

Adenovirus_DNA-bd_zn-bd

1

IPR005378

5,378

Vacuolar protein sorting-associated protein 35

Vps35

Family

6,660

false

This entry represents vacuolar protein sorting-associated protein 35 (Vps35) from eukaryotes. Vps35 is a core component of the retromer complex which functions in the endosome-to-Golgi retrieval cargo transport pathway [ , ]. Vps35 is part of the a cargo-selective complex trimer (CSC) of the retromer, which is composed...

[ "GO:0015031", "GO:0042147", "GO:0030906" ]

[ "protein transport", "retrograde transport, endosome to Golgi", "retromer, cargo-selective complex" ]

[ "biological_process", "biological_process", "cellular_component" ]

3

[ "PFAM", "PIRSF", "PANTHER" ]

[ "PF03635", "PIRSF009375", "PTHR11099" ]

[ "Vps35", "Retromer_Vps35", "" ]

[ 6629, 4925, 6493 ]

3

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-3238698", "R-DDI-3238698", "R-HSA-3238698", "R-MMU-3238698", "R-SCE-3238698", "R-SPO-3238698" ]

[ "REACTOME:R-BTA-3238698", "REACTOME:R-DDI-3238698", "REACTOME:R-HSA-3238698", "REACTOME:R-MMU-3238698", "REACTOME:R-SCE-3238698", "REACTOME:R-SPO-3238698" ]

6

[ "2r17", "5f0j", "5f0k", "5f0l", "5f0m", "5f0p", "5osh", "5osi", "6h7w", "6vab", "6vac", "7bln", "7blo", "7blp", "7blq", "7blr", "7u6f", "8r02", "8r0j", "8rks", "8tta", "8ttc" ]

22

[ "PUB00028000", "PUB00049218", "PUB00075395", "PUB00075396", "PUB00087283" ]

[ "11598206", "17891154", "25416282", "25937119", "23148298" ]

[ "Vps26p, a component of retromer, directs the interactions of Vps35p in endosome-to-Golgi retrieval.", "Functional architecture of the retromer cargo-recognition complex.", "Retromer-dependent neurotransmitter receptor trafficking to synapses is altered by the Parkinson's disease VPS35 mutation p.D620N.", "VP...

[ 2001, 2007, 2015, 2015, 2012 ]

5

[]

0

null

[ "Eukaryota" ]

[ 6660 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 25, 2, 3, 4, 3, 6, 1, 6, 6, 1, 1, 42 ]

12

true

Family

Vacuolar protein sorting-associated protein 35

Vps35

5

IPR005379

5,379

Factor of DNA methylation 1-5/IDN2 , domain XH

FDM1-5/IDN2_XH

Domain

4,617

false

The XH (rice gene X Homology) domain is found in a family of plant proteins including Oryza sativa (Rice) and Arabidopsis FDM1-5/IDN2. These proteins usually contain an XS domain ( ) that is also found in the PTGS protein SGS3. As the XS and XH domains are fused in most of these proteins, these two domains may interact...

[]

0

[ "PFAM" ]

[ "PF03469" ]

[ "XH" ]

[ 4617 ]

1

[]

0

[]

0

[ "PUB00007755", "PUB00072951", "PUB00098201" ]

[ "12162795", "22592791", "22757778" ]

[ "The SGS3 protein involved in PTGS finds a family.", "INVOLVED IN DE NOVO 2-containing complex involved in RNA-directed DNA methylation in Arabidopsis.", "The DNA- and RNA-binding protein FACTOR of DNA METHYLATION 1 requires XH domain-mediated complex formation for its function in RNA-directed DNA methylation."...

[ 2002, 2012, 2012 ]

3

[]

0

null

[ "Eukaryota", "Paenibacillus nuruki" ]

[ 4616, 1 ]

2

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 57, 36, 30 ]

3

true

Domain

Factor of DNA methylation 1-5/IDN2 , domain XH

FDM1-5/IDN2_XH

8

IPR005380

5,380

XS domain

XS_domain

Domain

5,861

false

This XS (named after rice gene X and SGS3) domain is a single-stranded RNA-binding domain (RBD) and possesses a unique version of a RNA recognition motif (RRM) fold [ ]. It is conserved in a family of plant proteins including gene X and SGS3. Although its function is still unknown, the plant SGS3 proteins are thought t...

[ "GO:0031047" ]

[ "regulatory ncRNA-mediated gene silencing" ]

[ "biological_process" ]

1

[ "PFAM", "CDD" ]

[ "PF03468", "cd12266" ]

[ "XS", "RRM_like_XS" ]

[ 5861, 2472 ]

2

[]

0

[ "4e8u" ]

1

[ "PUB00072951", "PUB00079468" ]

[ "22592791", "18635957" ]

[ "INVOLVED IN DE NOVO 2-containing complex involved in RNA-directed DNA methylation in Arabidopsis.", "The XS domain of a plant specific SGS3 protein adopts a unique RNA recognition motif (RRM) fold." ]

[ 2012, 2008 ]

2

[]

0

null

[ "Viridiplantae" ]

[ 5861 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 56, 29, 58 ]

3

true

Domain

XS domain

XS_domain

3

IPR005381

5,381

Zinc finger-XS domain

Znf-XS_domain

Domain

3,814

false

This domain is a putative nucleic acid binding zinc finger and is found at the N terminus of proteins that also contain an adjacent XS domain and in some proteins a C-terminal XH domain [ ]. Proteins containing this domain include protein SUPPRESSOR OF GENE SILENCING 3 (SGS3), which is required for post-transcriptional...

[ "GO:0031047" ]

[ "regulatory ncRNA-mediated gene silencing" ]

[ "biological_process" ]

1

[ "PFAM" ]

[ "PF03470" ]

[ "zf-XS" ]

[ 3814 ]

1

[]

0

[]

0

[ "PUB00066818", "PUB00066819", "PUB00072951" ]

[ "15466488", "15165191", "22592791" ]

[ "SGS3 and SGS2/SDE1/RDR6 are required for juvenile development and the production of trans-acting siRNAs in Arabidopsis.", "Geminivirus VIGS of endogenous genes requires SGS2/SDE1 and SGS3 and defines a new branch in the genetic pathway for silencing in plants.", "INVOLVED IN DE NOVO 2-containing complex involv...

[ 2004, 2004, 2012 ]

3

[]

0

null

[ "Acidobacterium capsulatum", "Eukaryota" ]

[ 1, 3813 ]

2

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 29, 18, 49 ]

3

true

Domain

Zinc finger-XS domain

Znf-XS_domain

2

IPR005383

5,383

Atypical chemokine receptor 4

ACKR4

Family

1,350

false

Just like classical chemokine receptors, atypical chemokine receptors (ACKRs) are seven-transmembrane-helix (7TM) receptors that bind chemokines [ ]. However, they lack the canonical DRYLAIV motif necessary for GPCR coupling to G proteins and induction of classical signalling pathways. Instead, ACKRs internalise their ...

[ "GO:0005044", "GO:0019956", "GO:0016020" ]

[ "scavenger receptor activity", "chemokine binding", "membrane" ]

[ "molecular_function", "molecular_function", "cellular_component" ]

3

[ "PRINTS" ]

[ "PR01558" ]

[ "CHEMOKINER11" ]

[ 1350 ]

1

[ "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-380108", "R-HSA-380108", "R-MMU-380108" ]

[ "REACTOME:R-BTA-380108", "REACTOME:R-HSA-380108", "REACTOME:R-MMU-380108" ]

3

[]

0

[ "PUB00064731", "PUB00064765", "PUB00077487", "PUB00077489", "PUB00077491", "PUB00077492" ]

[ "10706668", "23121557", "25521433", "24319779", "24549061", "16791897" ]

[ "Cutting edge: identification of a novel chemokine receptor that binds dendritic cell- and T cell-active chemokines including ELC, SLC, and TECK.", "Inhibition of CXCR3-mediated chemotaxis by the human chemokine receptor-like protein CCX-CKR.", "CCRL1/ACKR4 is expressed in key thymic microenvironments but is di...

[ 2000, 2013, 2015, 2013, 2014, 2006 ]

6

[ "IPR000355" ]

[]

1

0

1

[ "Gnathostomata", "Lymphocystivirus" ]

[ 1347, 3 ]

2

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 3, 2, 3 ]

4

true

Family

Atypical chemokine receptor 4

ACKR4

9

IPR005384

5,384

Duffy antigen/chemokine receptor

Duffy_chemokine_rcpt

Family

733

false

Chemokines (chemotactic cytokines) are a family of chemoattractant molecules. They attract leukocytes to areas of inflammation and lesions, and play a key role in leukocyte activation. Originally defined as host defense proteins, chemokines are now known to play a much broader biological role [ ]. They have a wide rang...

[ "GO:0019956", "GO:0006954", "GO:0070098", "GO:0016020" ]

[ "chemokine binding", "inflammatory response", "chemokine-mediated signaling pathway", "membrane" ]

[ "molecular_function", "biological_process", "biological_process", "cellular_component" ]

4

[ "PANTHER" ]

[ "PTHR14181" ]

[ "" ]

[ 733 ]

1

[ "REACTOME" ]

[ "R-HSA-375276" ]

[ "REACTOME:R-HSA-375276" ]

1

[ "8jps", "8ynf" ]

2

[ "PUB00007758", "PUB00009401", "PUB00064589", "PUB00064621", "PUB00064622", "PUB00064677", "PUB00066891", "PUB00066892", "PUB00066893", "PUB00066894", "PUB00066895", "PUB00066896", "PUB00066897", "PUB00066898", "PUB00066900", "PUB00066901", "PUB00066902", "PUB00066903", "PUB000669...

[ "9129009", "11544102", "10714678", "10601351", "9500790", "10699158", "8248172", "7663520", "7689250", "8132497", "7517400", "23224555", "19060902", "22246380", "9058825", "8083383", "12734373", "10961863", "12081195", "16054417", "15572394", "7699323", "10201015", "968...

[ "From malaria to chemokine receptor: the emerging physiologic role of the Duffy blood group antigen.", "Chemokine receptors.", "Chemokines: a new classification system and their role in immunity.", "Macrophage inflammatory protein 3alpha is involved in the constitutive trafficking of epidermal langerhans cell...

[ 1997, 2001, 2000, 1999, 1998, 2000, 1993, 1995, 1993, 1994, 1994, 2012, 2009, 2012, 1997, 1994, 2003, 2000, 2002, 2005, 2005, 1995, 1999, 1998, 1995 ]

25

[]

0

null

[ "Amniota" ]

[ 733 ]

1

[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 38, 5, 5 ]

3

true

Family

Duffy antigen/chemokine receptor

Duffy_chemokine_rcpt

7

IPR005385

5,385

Lysophosphatidic acid receptor EDG-7

LPA_rcpt_EDG7

Family

837

false

G protein-coupled receptors (GPCRs) constitute a vast protein family that encompasses a wide range of functions, including various autocrine, paracrine and endocrine processes. They show considerable diversity at the sequence level, on the basis of which they can be separated into distinct groups [ ]. The term clan can...

[ "GO:0070915", "GO:0007186", "GO:0016020" ]

[ "lysophosphatidic acid receptor activity", "G protein-coupled receptor signaling pathway", "membrane" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PRINTS" ]

[ "PR01560" ]

[ "EDG7RECEPTOR" ]

[ 837 ]

1

[ "IUPHAR", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "274", "R-HSA-416476", "R-HSA-418594", "R-HSA-419408", "R-MMU-416476", "R-MMU-418594", "R-MMU-419408", "R-RNO-416476", "R-RNO-418594", "R-RNO-419408" ]

[ "IUPHAR:274", "REACTOME:R-HSA-416476", "REACTOME:R-HSA-418594", "REACTOME:R-HSA-419408", "REACTOME:R-MMU-416476", "REACTOME:R-MMU-418594", "REACTOME:R-MMU-419408", "REACTOME:R-RNO-416476", "REACTOME:R-RNO-418594", "REACTOME:R-RNO-419408" ]

10

[]

0

[ "PUB00000131", "PUB00002477", "PUB00004960", "PUB00004961", "PUB00007190", "PUB00053635", "PUB00063577", "PUB00063578", "PUB00063579", "PUB00063580", "PUB00063816" ]

[ "2111655", "2830256", "8386361", "8170923", "11093753", "12679517", "8081729", "15914470", "18948278", "16753280", "23020293" ]

[ "G proteins in signal transduction.", "G protein involvement in receptor-effector coupling.", "Design of a discriminating fingerprint for G-protein-coupled receptors.", "Fingerprinting G-protein-coupled receptors.", "Lysophosphatidic acid receptors.", "The G protein-coupled receptor repertoires of human a...

[ 1990, 1988, 1993, 1994, 2000, 2003, 1994, 2005, 2009, 2006, 2013 ]

11

[ "IPR004065" ]

[]

1

0

1

[ "Gnathostomata" ]

[ 837 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 2, 2, 3 ]

4

true

Family

Lysophosphatidic acid receptor EDG-7

LPA_rcpt_EDG7

2

IPR005386

5,386

EDG-8 sphingosine 1-phosphate receptor

EDG8_S1P_rcpt

Family

206

false

G protein-coupled receptors (GPCRs) constitute a vast protein family that encompasses a wide range of functions, including various autocrine, paracrine and endocrine processes. They show considerable diversity at the sequence level, on the basis of which they can be separated into distinct groups [ ]. The term clan can...

[ "GO:0038036", "GO:0007186", "GO:0016020" ]

[ "sphingosine-1-phosphate receptor activity", "G protein-coupled receptor signaling pathway", "membrane" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PRINTS" ]

[ "PR01561" ]

[ "EDG8RECEPTOR" ]

[ 206 ]

1

[ "IUPHAR", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "279", "R-HSA-418594", "R-HSA-419408", "R-MMU-418594", "R-MMU-419408", "R-RNO-418594", "R-RNO-419408", "R-SSC-418594", "R-SSC-419408" ]

[ "IUPHAR:279", "REACTOME:R-HSA-418594", "REACTOME:R-HSA-419408", "REACTOME:R-MMU-418594", "REACTOME:R-MMU-419408", "REACTOME:R-RNO-418594", "REACTOME:R-RNO-419408", "REACTOME:R-SSC-418594", "REACTOME:R-SSC-419408" ]

9

[ "7ew1", "7yxa" ]

2

[ "PUB00000131", "PUB00002477", "PUB00004960", "PUB00004961", "PUB00007103", "PUB00007105", "PUB00007759", "PUB00053635", "PUB00063577", "PUB00063578", "PUB00063579", "PUB00063580", "PUB00063816" ]

[ "2111655", "2830256", "8386361", "8170923", "11264467", "11150592", "1106989", "12679517", "8081729", "15914470", "18948278", "16753280", "23020293" ]

[ "G proteins in signal transduction.", "G protein involvement in receptor-effector coupling.", "Design of a discriminating fingerprint for G-protein-coupled receptors.", "Fingerprinting G-protein-coupled receptors.", "Lysophospholipid receptors.", "Sphingosine 1-phosphate signalling via the endothelial dif...

[ 1990, 1988, 1993, 1994, 2001, 2000, 1975, 2003, 1994, 2005, 2009, 2006, 2013 ]

13

[ "IPR004061" ]

[]

1

0

1

[ "Actinomycetota", "Eukaryota" ]

[ 6, 200 ]

2

[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 4, 1, 2 ]

3

true

Family

EDG-8 sphingosine 1-phosphate receptor

EDG8_S1P_rcpt

2

IPR005387

5,387

CX3C chemokine receptor 1

Chemokine_CX3CR1

Family

246

false

Chemokines (chemotactic cytokines) are a family of chemoattractant molecules. They attract leukocytes to areas of inflammation and lesions, and play a key role in leukocyte activation. Originally defined as host defense proteins, chemokines are now known to play a much broader biological role [ ]. They have a wide rang...

[ "GO:0016495", "GO:0006935", "GO:0007155", "GO:0007186", "GO:0016020" ]

[ "C-X3-C chemokine receptor activity", "chemotaxis", "cell adhesion", "G protein-coupled receptor signaling pathway", "membrane" ]

[ "molecular_function", "biological_process", "biological_process", "biological_process", "cellular_component" ]

5

[ "PRINTS" ]

[ "PR01562" ]

[ "FRACTALKINER" ]

[ 246 ]

1

[ "IUPHAR", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "74", "R-BTA-380108", "R-BTA-418594", "R-HSA-380108", "R-HSA-418594", "R-HSA-9820960", "R-HSA-9833110", "R-MMU-380108", "R-MMU-418594", "R-RNO-380108", "R-RNO-418594" ]

[ "IUPHAR:74", "REACTOME:R-BTA-380108", "REACTOME:R-BTA-418594", "REACTOME:R-HSA-380108", "REACTOME:R-HSA-418594", "REACTOME:R-HSA-9820960", "REACTOME:R-HSA-9833110", "REACTOME:R-MMU-380108", "REACTOME:R-MMU-418594", "REACTOME:R-RNO-380108", "REACTOME:R-RNO-418594" ]

11

[ "7xbw", "7xbx" ]

2

[ "PUB00007760", "PUB00007761", "PUB00009401", "PUB00010311", "PUB00064589", "PUB00064621", "PUB00064622", "PUB00064962", "PUB00064963", "PUB00067945", "PUB00067946" ]

[ "9390561", "9726990", "11544102", "9024663", "10714678", "10601351", "9500790", "15786508", "7590284", "9689100", "7592998" ]

[ "Identification and molecular characterization of fractalkine receptor CX3CR1, which mediates both leukocyte migration and adhesion.", "Identification of CX3CR1. A chemotactic receptor for the human CX3C chemokine fractalkine and a fusion coreceptor for HIV-1.", "Chemokine receptors.", "A new class of membran...

[ 1997, 1998, 2001, 1997, 2000, 1999, 1998, 2005, 1995, 1998, 1995 ]

11

[]

0

null

[ "Amniota" ]

[ 246 ]

1

[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 3, 4, 2 ]

3

true

Family

CX3C chemokine receptor 1

Chemokine_CX3CR1

9

IPR005388

5,388

G2A lysophosphatidylcholine receptor

G2A_lysphc_rcpt

Family

245

false

G protein-coupled receptors (GPCRs) constitute a vast protein family that encompasses a wide range of functions, including various autocrine, paracrine and endocrine processes. They show considerable diversity at the sequence level, on the basis of which they can be separated into distinct groups [ ]. The term clan can...

[ "GO:0007186", "GO:0016020" ]

[ "G protein-coupled receptor signaling pathway", "membrane" ]

[ "biological_process", "cellular_component" ]

2

[ "PRINTS" ]

[ "PR01563" ]

[ "G2ARECEPTOR" ]

[ 245 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-373076", "R-HSA-416476", "R-MMU-373076", "R-MMU-416476" ]

[ "REACTOME:R-HSA-373076", "REACTOME:R-HSA-416476", "REACTOME:R-MMU-373076", "REACTOME:R-MMU-416476" ]

4

[ "8hqe", "8hqm", "8hqn", "8hvi" ]

4

[ "PUB00000131", "PUB00002477", "PUB00004960", "PUB00004961", "PUB00007763", "PUB00053635", "PUB00063577", "PUB00063578", "PUB00063579", "PUB00063580", "PUB00063816" ]

[ "2111655", "2830256", "8386361", "8170923", "11371358", "12679517", "8081729", "15914470", "18948278", "16753280", "23020293" ]

[ "G proteins in signal transduction.", "G protein involvement in receptor-effector coupling.", "Design of a discriminating fingerprint for G-protein-coupled receptors.", "Fingerprinting G-protein-coupled receptors.", "Mice lacking the orphan G protein-coupled receptor G2A develop a late-onset autoimmune synd...

[ 1990, 1988, 1993, 1994, 2001, 2003, 1994, 2005, 2009, 2006, 2013 ]

11

[ "IPR000276" ]

[]

1

0

1

[ "Tetrapoda" ]

[ 245 ]

1

[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 1, 4 ]

3

true

Family

G2A lysophosphatidylcholine receptor

G2A_lysphc_rcpt

8

IPR005389

5,389

OGR1 sphingosylphosphorylcholine receptor

OGR1_rcpt

Family

765

false

G protein-coupled receptors (GPCRs) constitute a vast protein family that encompasses a wide range of functions, including various autocrine, paracrine and endocrine processes. They show considerable diversity at the sequence level, on the basis of which they can be separated into distinct groups [ ]. The term clan can...

[ "GO:0007186", "GO:0016020" ]

[ "G protein-coupled receptor signaling pathway", "membrane" ]

[ "biological_process", "cellular_component" ]

2

[ "PRINTS" ]

[ "PR01564" ]

[ "OGR1RECEPTOR" ]

[ 765 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-373076", "R-BTA-416476", "R-HSA-373076", "R-HSA-416476", "R-MMU-373076", "R-MMU-416476" ]

[ "REACTOME:R-BTA-373076", "REACTOME:R-BTA-416476", "REACTOME:R-HSA-373076", "REACTOME:R-HSA-416476", "REACTOME:R-MMU-373076", "REACTOME:R-MMU-416476" ]

6

[ "8z3o", "8z5h", "8z68", "9bhm", "9bi6" ]

5

[ "PUB00000131", "PUB00002477", "PUB00004960", "PUB00004961", "PUB00007765", "PUB00053635", "PUB00063577", "PUB00063578", "PUB00063579", "PUB00063580", "PUB00063816" ]

[ "2111655", "2830256", "8386361", "8170923", "8661159", "12679517", "8081729", "15914470", "18948278", "16753280", "23020293" ]

[ "G proteins in signal transduction.", "G protein involvement in receptor-effector coupling.", "Design of a discriminating fingerprint for G-protein-coupled receptors.", "Fingerprinting G-protein-coupled receptors.", "Identification of human OGR1, a novel G protein-coupled receptor that maps to chromosome 14...

[ 1990, 1988, 1993, 1994, 1996, 2003, 1994, 2005, 2009, 2006, 2013 ]

11

[ "IPR000276" ]

[]

1

0

1

[ "Gnathostomata" ]

[ 765 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 5, 2, 2 ]

4

true

Family

OGR1 sphingosylphosphorylcholine receptor

OGR1_rcpt

7

IPR005390

5,390

Neuromedin U receptor

NeuromedU_rcpt

Family

3,024

false

G protein-coupled receptors (GPCRs) constitute a vast protein family that encompasses a wide range of functions, including various autocrine, paracrine and endocrine processes. They show considerable diversity at the sequence level, on the basis of which they can be separated into distinct groups [ ]. The term clan can...

[ "GO:0001607", "GO:0007186", "GO:0016020" ]

[ "neuromedin U receptor activity", "G protein-coupled receptor signaling pathway", "membrane" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PRINTS" ]

[ "PR01565" ]

[ "NEUROMEDINUR" ]

[ 3024 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-DME-416476", "R-HSA-375276", "R-HSA-416476", "R-HSA-418594", "R-MMU-375276", "R-MMU-416476", "R-MMU-418594", "R-RNO-375276", "R-RNO-416476", "R-RNO-418594" ]

[ "REACTOME:R-DME-416476", "REACTOME:R-HSA-375276", "REACTOME:R-HSA-416476", "REACTOME:R-HSA-418594", "REACTOME:R-MMU-375276", "REACTOME:R-MMU-416476", "REACTOME:R-MMU-418594", "REACTOME:R-RNO-375276", "REACTOME:R-RNO-416476", "REACTOME:R-RNO-418594" ]

10

[ "7w53", "7w55", "7w56", "7w57", "7xk8" ]

5

[ "PUB00000131", "PUB00002477", "PUB00004960", "PUB00004961", "PUB00007766", "PUB00007767", "PUB00053635", "PUB00063577", "PUB00063578", "PUB00063579", "PUB00063580", "PUB00063816" ]

[ "2111655", "2830256", "8386361", "8170923", "10899166", "10894543", "12679517", "8081729", "15914470", "18948278", "16753280", "23020293" ]

[ "G proteins in signal transduction.", "G protein involvement in receptor-effector coupling.", "Design of a discriminating fingerprint for G-protein-coupled receptors.", "Fingerprinting G-protein-coupled receptors.", "Identification and characterization of two neuromedin U receptors differentially expressed ...

[ 1990, 1988, 1993, 1994, 2000, 2000, 2003, 1994, 2005, 2009, 2006, 2013 ]

12

[ "IPR000276" ]

[ "IPR005391", "IPR005392" ]

1

2

0

[ "Bilateria" ]

[ 3024 ]

1

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 6, 3, 4, 6, 8 ]

5

true

Family

Neuromedin U receptor

NeuromedU_rcpt

2

IPR005391

5,391

Neuromedin U receptor, type 1

NeuromedU_rcpt_1

Family

749

false

G protein-coupled receptors (GPCRs) constitute a vast protein family that encompasses a wide range of functions, including various autocrine, paracrine and endocrine processes. They show considerable diversity at the sequence level, on the basis of which they can be separated into distinct groups [ ]. The term clan can...

[ "GO:0001607", "GO:0007186", "GO:0016020" ]

[ "neuromedin U receptor activity", "G protein-coupled receptor signaling pathway", "membrane" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PRINTS" ]

[ "PR01566" ]

[ "NEUROMEDNU1R" ]

[ 749 ]

1

[ "IUPHAR", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "298", "R-HSA-375276", "R-HSA-416476", "R-HSA-418594", "R-MMU-375276", "R-MMU-416476", "R-MMU-418594", "R-RNO-375276", "R-RNO-416476", "R-RNO-418594" ]

[ "IUPHAR:298", "REACTOME:R-HSA-375276", "REACTOME:R-HSA-416476", "REACTOME:R-HSA-418594", "REACTOME:R-MMU-375276", "REACTOME:R-MMU-416476", "REACTOME:R-MMU-418594", "REACTOME:R-RNO-375276", "REACTOME:R-RNO-416476", "REACTOME:R-RNO-418594" ]

10

[ "7w53", "7w56" ]

2

[ "PUB00000131", "PUB00002477", "PUB00004960", "PUB00004961", "PUB00007766", "PUB00007767", "PUB00053635", "PUB00063577", "PUB00063578", "PUB00063579", "PUB00063580", "PUB00063816" ]

[ "2111655", "2830256", "8386361", "8170923", "10899166", "10894543", "12679517", "8081729", "15914470", "18948278", "16753280", "23020293" ]

[ "G proteins in signal transduction.", "G protein involvement in receptor-effector coupling.", "Design of a discriminating fingerprint for G-protein-coupled receptors.", "Fingerprinting G-protein-coupled receptors.", "Identification and characterization of two neuromedin U receptors differentially expressed ...

[ 1990, 1988, 1993, 1994, 2000, 2000, 2003, 1994, 2005, 2009, 2006, 2013 ]

12

[ "IPR005390" ]

[]

1

0

1

[ "Gnathostomata" ]

[ 749 ]

1

[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 3, 3, 4 ]

3

true

Family

Neuromedin U receptor, type 1

NeuromedU_rcpt_1

1

IPR005392

5,392

Neuromedin U receptor, type 2

NeuromedU_rcpt_2

Family

634

false

G protein-coupled receptors (GPCRs) constitute a vast protein family that encompasses a wide range of functions, including various autocrine, paracrine and endocrine processes. They show considerable diversity at the sequence level, on the basis of which they can be separated into distinct groups [ ]. The term clan can...

[ "GO:0001607", "GO:0007186", "GO:0016020" ]

[ "neuromedin U receptor activity", "G protein-coupled receptor signaling pathway", "membrane" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PRINTS" ]

[ "PR01567" ]

[ "NEUROMEDNU2R" ]

[ 634 ]

1

[ "IUPHAR", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "299", "R-HSA-375276", "R-HSA-416476", "R-HSA-418594", "R-MMU-375276", "R-MMU-416476", "R-MMU-418594", "R-RNO-375276", "R-RNO-416476", "R-RNO-418594" ]

[ "IUPHAR:299", "REACTOME:R-HSA-375276", "REACTOME:R-HSA-416476", "REACTOME:R-HSA-418594", "REACTOME:R-MMU-375276", "REACTOME:R-MMU-416476", "REACTOME:R-MMU-418594", "REACTOME:R-RNO-375276", "REACTOME:R-RNO-416476", "REACTOME:R-RNO-418594" ]

10

[ "7w55", "7w57", "7xk8" ]

3

[ "PUB00000131", "PUB00002477", "PUB00004960", "PUB00004961", "PUB00007766", "PUB00007767", "PUB00053635", "PUB00063577", "PUB00063578", "PUB00063579", "PUB00063580", "PUB00063816" ]

[ "2111655", "2830256", "8386361", "8170923", "10899166", "10894543", "12679517", "8081729", "15914470", "18948278", "16753280", "23020293" ]

[ "G proteins in signal transduction.", "G protein involvement in receptor-effector coupling.", "Design of a discriminating fingerprint for G-protein-coupled receptors.", "Fingerprinting G-protein-coupled receptors.", "Identification and characterization of two neuromedin U receptors differentially expressed ...

[ 1990, 1988, 1993, 1994, 2000, 2000, 2003, 1994, 2005, 2009, 2006, 2013 ]

12

[ "IPR005390" ]

[]

1

0

1

[ "Vertebrata" ]

[ 634 ]

1

[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 2, 4 ]

3

true

Family

Neuromedin U receptor, type 2

NeuromedU_rcpt_2

6

IPR005393

5,393

XC chemokine receptor 1

Chemokine_XCR1

Family

570

false

Chemokines (chemotactic cytokines) are a family of chemoattractant molecules. They attract leukocytes to areas of inflammation and lesions, and play a key role in leukocyte activation. Originally defined as host defense proteins, chemokines are now known to play a much broader biological role [ ]. They have a wide rang...

[ "GO:0004950", "GO:0006935", "GO:0007186", "GO:0016020" ]

[ "chemokine receptor activity", "chemotaxis", "G protein-coupled receptor signaling pathway", "membrane" ]

[ "molecular_function", "biological_process", "biological_process", "cellular_component" ]

4

[ "PRINTS" ]

[ "PR01568" ]

[ "LYMPHOTACTNR" ]

[ 570 ]

1

[ "IUPHAR", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "75", "R-HSA-380108", "R-HSA-416476", "R-MMU-380108", "R-MMU-416476" ]

[ "IUPHAR:75", "REACTOME:R-HSA-380108", "REACTOME:R-HSA-416476", "REACTOME:R-MMU-380108", "REACTOME:R-MMU-416476" ]

5

[ "9ast" ]

1

[ "PUB00007768", "PUB00007769", "PUB00007770", "PUB00009401", "PUB00064589", "PUB00064621", "PUB00064622", "PUB00064968", "PUB00064969", "PUB00067945", "PUB00067946" ]

[ "7973732", "9632725", "10518929", "11544102", "10714678", "10601351", "9500790", "7602097", "8977329", "9689100", "7592998" ]

[ "Lymphotactin: a cytokine that represents a new class of chemokine.", "Identification of single C motif-1/lymphotactin receptor XCR1.", "Molecular cloning of mXCR1, the murine SCM-1/lymphotactin receptor.", "Chemokine receptors.", "Chemokines: a new classification system and their role in immunity.", "Mac...

[ 1994, 1998, 1999, 2001, 2000, 1999, 1998, 1995, 1996, 1998, 1995 ]

11

[]

0

null

[ "Euteleostomi" ]

[ 570 ]

1

[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 3, 16, 22 ]

3

true

Family

XC chemokine receptor 1

Chemokine_XCR1

7

IPR005394

5,394

P2Y12 purinoceptor

P2Y12_rcpt

Family

623

false

There are three distinct families of extracellular receptors for purine and pyrimidine nucleotides [ ], known as P1, P2X and P2Y purinoceptors [ ]. These receptors induce a wide variety of biological effects and are involved in many different cellular functions [ , , ]. P2X receptors are ligand-gated ion channels, wher...

[ "GO:0045028", "GO:0007186", "GO:0007596", "GO:0016020" ]

[ "G protein-coupled purinergic nucleotide receptor activity", "G protein-coupled receptor signaling pathway", "blood coagulation", "membrane" ]

[ "molecular_function", "biological_process", "biological_process", "cellular_component" ]

4

[ "PRINTS", "CDD" ]

[ "PR01569", "cd15150" ]

[ "P2Y12PRNCPTR", "7tmA_P2Y12" ]

[ 601, 536 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-392170", "R-HSA-417957", "R-HSA-418594", "R-MMU-392170", "R-MMU-417957", "R-MMU-418594", "R-RNO-392170", "R-RNO-417957", "R-RNO-418594" ]

[ "REACTOME:R-HSA-392170", "REACTOME:R-HSA-417957", "REACTOME:R-HSA-418594", "REACTOME:R-MMU-392170", "REACTOME:R-MMU-417957", "REACTOME:R-MMU-418594", "REACTOME:R-RNO-392170", "REACTOME:R-RNO-417957", "REACTOME:R-RNO-418594" ]

9

[ "4ntj", "4pxz", "4py0", "7pp1", "7xxi" ]

5

[ "PUB00007054", "PUB00007772", "PUB00007773", "PUB00028347", "PUB00033968", "PUB00066193", "PUB00066194", "PUB00066195", "PUB00066196", "PUB00066197", "PUB00066198", "PUB00066203", "PUB00066204", "PUB00066205", "PUB00066206", "PUB00066207", "PUB00066208", "PUB00066209", "PUB000662...

[ "12270951", "11104774", "11196645", "8872457", "11111826", "10629443", "20471713", "11099464", "19921464", "11734617", "16257449", "9364468", "7724657", "16968944", "8508924", "19386608", "8921391", "8702478", "12724320", "18404483", "9755289", "11794691", "16914897", "...

[ "Molecular physiology of P2X receptors.", "ADP is the cognate ligand for the orphan G protein-coupled receptor SP1999.", "Identification of the platelet ADP receptor targeted by antithrombotic drugs.", "Modelling the P2Y purinoceptor using rhodopsin as template.", "Molecular pharmacology of P2Y-receptors.",...

[ 2002, 2001, 2001, 1995, 2000, 2000, 2011, 2000, 2010, 2001, 2006, 1997, 1994, 2006, 1993, 2009, 1996, 1996, 2003, 2006, 1998, 2001, 2006, 2006, 2000, 2005, 2004, 2002, 1975, 2004, 2005, 2003, 2003, 2001, 2004 ]

35

[ "IPR000276" ]

[]

1

0

1

[ "Gnathostomata" ]

[ 623 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 5, 3, 3 ]

4

true

Family

P2Y12 purinoceptor

P2Y12_rcpt

7

IPR005395

5,395

Neuropeptide FF receptor family

NPFF_rcpt

Family

2,854

false

Neuropeptide FF receptors [ ] belong to a family of neuropeptides containing an RF-amide motif at their C terminus which have a high affinity for the pain modulatory peptide neuropeptide NPFF (NPFF) [ ]. Neuropeptide FF (NPFF) receptors have two subtypes, neuropeptide FF receptor type 1 (NPFF1) and neuropeptide FF rece...

[ "GO:0008188", "GO:0007186", "GO:0016020" ]

[ "neuropeptide receptor activity", "G protein-coupled receptor signaling pathway", "membrane" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PRINTS" ]

[ "PR01570" ]

[ "NPFFRECEPTOR" ]

[ 2854 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-389397", "R-HSA-416476", "R-MMU-389397", "R-MMU-416476", "R-RNO-389397", "R-RNO-416476" ]

[ "REACTOME:R-HSA-389397", "REACTOME:R-HSA-416476", "REACTOME:R-MMU-389397", "REACTOME:R-MMU-416476", "REACTOME:R-RNO-389397", "REACTOME:R-RNO-416476" ]

6

[ "9jfy", "9jg0", "9m0r", "9m1o", "9m2f", "9m54" ]

6

[ "PUB00007774", "PUB00063682", "PUB00063683", "PUB00063684", "PUB00063685", "PUB00063686", "PUB00063687", "PUB00063688", "PUB00063693", "PUB00063694", "PUB00063695", "PUB00063722" ]

[ "8804117", "10837915", "10851242", "16443306", "17224450", "17854890", "18804517", "18823989", "9593588", "10612711", "20803521", "14696013" ]

[ "Neuropeptide FF, a mammalian neuropeptide with multiple functions.", "Molecular cloning and characterisation of GPR74 a novel G-protein coupled receptor closest related to the Y-receptor family.", "Receptor for the pain modulatory neuropeptides FF and AF is an orphan G protein-coupled receptor.", "Modulatory...

[ 1996, 2000, 2000, 2006, 2007, 2008, 2008, 2008, 1998, 1999, 2010, 2004 ]

12

[ "IPR000276" ]

[ "IPR005396", "IPR005397" ]

1

2

0

[ "Eumetazoa" ]

[ 2854 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 14, 4, 4, 7 ]

4

true

Family

Neuropeptide FF receptor family

NPFF_rcpt

7

IPR005396

5,396

Neuropeptide FF receptor, type 1

NPFF_rcpt_1

Family

680

false

Neuropeptide FF receptors [ ] belong to a family of neuropeptides containing an RF-amide motif at their C terminus which have a high affinity for the pain modulatory peptide neuropeptide NPFF (NPFF) [ ]. Neuropeptide FF (NPFF) receptors have two subtypes, neuropeptide FF receptor type 1 (NPFF1) and neuropeptide FF rece...

[ "GO:0008188", "GO:0007186", "GO:0016020" ]

[ "neuropeptide receptor activity", "G protein-coupled receptor signaling pathway", "membrane" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PRINTS" ]

[ "PR01571" ]

[ "NPFFRECEPTR1" ]

[ 680 ]

1

[ "IUPHAR", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "300", "R-HSA-389397", "R-HSA-416476", "R-RNO-389397", "R-RNO-416476" ]

[ "IUPHAR:300", "REACTOME:R-HSA-389397", "REACTOME:R-HSA-416476", "REACTOME:R-RNO-389397", "REACTOME:R-RNO-416476" ]

5

[ "9m0r", "9m2f" ]

2

[ "PUB00007774", "PUB00007777", "PUB00063682", "PUB00063683", "PUB00063684", "PUB00063685", "PUB00063686", "PUB00063687", "PUB00063688", "PUB00063690", "PUB00063693", "PUB00063694", "PUB00063695", "PUB00063722" ]

[ "8804117", "11025660", "10837915", "10851242", "16443306", "17224450", "17854890", "18804517", "18823989", "11481330", "9593588", "10612711", "20803521", "14696013" ]

[ "Neuropeptide FF, a mammalian neuropeptide with multiple functions.", "New neuropeptides containing carboxy-terminal RFamide and their receptor in mammals.", "Molecular cloning and characterisation of GPR74 a novel G-protein coupled receptor closest related to the Y-receptor family.", "Receptor for the pain m...

[ 1996, 2000, 2000, 2000, 2006, 2007, 2008, 2008, 2008, 2001, 1998, 1999, 2010, 2004 ]

14

[ "IPR005395" ]

[]

1

0

1

[ "Euteleostomi" ]

[ 680 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 1, 1, 5 ]

4

true

Family

Neuropeptide FF receptor, type 1

NPFF_rcpt_1

3

IPR005397

5,397

Neuropeptide FF receptor, type 2

NPFF_rcpt_2

Family

1,030

false

This entry represents NPFF2, which is expressed at high levels in the thymus and placenta, with moderate levels in the pituitary, spleen, testis and brain. Low levels were detected in the spinal cord, pancreas, small intestine, uterus, stomach, lung, heart and skeletal muscle. No expression was detected in liver or kid...

[ "GO:0008188", "GO:0031628", "GO:0007186", "GO:0043408", "GO:0045761", "GO:0016020" ]

[ "neuropeptide receptor activity", "opioid receptor binding", "G protein-coupled receptor signaling pathway", "regulation of MAPK cascade", "regulation of adenylate cyclase activity", "membrane" ]

[ "molecular_function", "molecular_function", "biological_process", "biological_process", "biological_process", "cellular_component" ]

6

[ "PRINTS" ]

[ "PR01572" ]

[ "NPFFRECEPTR2" ]

[ 1030 ]

1

[ "IUPHAR", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "301", "R-HSA-389397", "R-HSA-416476", "R-MMU-389397", "R-MMU-416476", "R-RNO-389397", "R-RNO-416476" ]

[ "IUPHAR:301", "REACTOME:R-HSA-389397", "REACTOME:R-HSA-416476", "REACTOME:R-MMU-389397", "REACTOME:R-MMU-416476", "REACTOME:R-RNO-389397", "REACTOME:R-RNO-416476" ]

7

[ "9jfy", "9jg0", "9m1o", "9m54" ]

4

[ "PUB00007774", "PUB00007775", "PUB00063682", "PUB00063683", "PUB00063684", "PUB00063685", "PUB00063686", "PUB00063687", "PUB00063688", "PUB00063693", "PUB00063694", "PUB00063695", "PUB00063699", "PUB00063700", "PUB00063701", "PUB00063702", "PUB00063703", "PUB00063722" ]

[ "8804117", "11325803", "10837915", "10851242", "16443306", "17224450", "17854890", "18804517", "18823989", "9593588", "10612711", "20803521", "10536200", "12932818", "16488058", "15608144", "22375000", "14696013" ]

[ "Neuropeptide FF, a mammalian neuropeptide with multiple functions.", "Functional characterization of a human receptor for neuropeptide FF and related peptides.", "Molecular cloning and characterisation of GPR74 a novel G-protein coupled receptor closest related to the Y-receptor family.", "Receptor for the p...

[ 1996, 2001, 2000, 2000, 2006, 2007, 2008, 2008, 2008, 1998, 1999, 2010, 1999, 2003, 2006, 2005, 2012, 2004 ]

18

[ "IPR005395" ]

[]

1

0

1

[ "Chordata" ]

[ 1030 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 3, 2, 2 ]

4

true

Family

Neuropeptide FF receptor, type 2

NPFF_rcpt_2

6

IPR005398

5,398

Tubby, N-terminal

Tubby_N

Domain

3,560

false

A mutation in the mouse tub gene causes maturity-onset obesity, insulin resistance and sensory deficits [ , ]. By contrast with the rapid juvenile-onset weight gain seen in diabetes (db) and obese (ob) mice, obesity in tubby mice develops gradually, and strongly resembles the late-onset obesity observed in the human po...

[]

0

[ "PFAM", "PRINTS" ]

[ "PF16322", "PR01574" ]

[ "Tub_N", "TUBBYPROTEIN" ]

[ 3071, 3007 ]

2

[ "REACTOME", "REACTOME" ]

[ "R-HSA-5610787", "R-MMU-5610787" ]

[ "REACTOME:R-HSA-5610787", "REACTOME:R-MMU-5610787" ]

2

[ "8fh3", "9e2g", "9e5c" ]

3

[ "PUB00000932", "PUB00004232", "PUB00007281", "PUB00076550" ]

[ "8612280", "8606774", "10591637", "11801719" ]

[ "Identification and characterization of the mouse obesity gene tubby: a member of a novel gene family.", "A candidate gene for the mouse mutation tubby.", "Implication of tubby proteins as transcription factors by structure-based functional analysis.", "The tubby-like proteins, a family with roles in neuronal...

[ 1996, 1996, 1999, 2002 ]

4

[]

0

null

[ "Bacteria", "Eukaryota", "ecological metagenomes" ]

[ 48, 3509, 3 ]

3

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus" ]

[ 9, 12, 11, 1, 15 ]

5

true

Domain

Tubby, N-terminal

Tubby_N

6

IPR005399

5,399

Potassium channel, voltage-dependent, beta subunit, KCNAB-related

K_chnl_volt-dep_bsu_KCNAB-rel

Family

28,071

false

This entry consists of the voltage-dependent potassium channel beta subunit KCNAB and related proteins. The bacterial proteins in this entry lack apparent alpha subunit partners and predicted to function as soluble aldo/keto reductase enzymes [ , ]. Potassium channels are the most diverse group of the ion channel famil...

[]

0

[ "PRINTS", "PANTHER" ]

[ "PR01577", "PTHR43150" ]

[ "KCNABCHANNEL", "" ]

[ 14268, 27785 ]

2

[ "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC"...

[ "1.1.1.-", "PWY-1121", "PWY-1186", "PWY-2541", "PWY-2601", "PWY-3162", "PWY-321", "PWY-3261", "PWY-3722", "PWY-5101", "PWY-5271", "PWY-5316", "PWY-5392", "PWY-5652", "PWY-5666", "PWY-5751", "PWY-5782", "PWY-5818", "PWY-5830", "PWY-5848", "PWY-5867", "PWY-5882", "PWY-5883"...

[ "EC:1.1.1.-", "METACYC:PWY-1121", "METACYC:PWY-1186", "METACYC:PWY-2541", "METACYC:PWY-2601", "METACYC:PWY-3162", "METACYC:PWY-321", "METACYC:PWY-3261", "METACYC:PWY-3722", "METACYC:PWY-5101", "METACYC:PWY-5271", "METACYC:PWY-5316", "METACYC:PWY-5392", "METACYC:PWY-5652", "METACYC:PWY-56...

158

[ "1exb", "1qrq", "1zsx", "2a79", "2r9r", "3eau", "3eb3", "3eb4", "3erp", "3lnm", "3lut", "3n6q", "4ast", "4aub", "4jta", "4jtc", "4jtd", "5t79", "5wie", "6ci1", "6ebk", "6ebl", "6hg6", "6ovq", "6ovx", "6ow0", "7ej1", "7ej2", "7sit", "7siz", "7wf3", "7wf4"...

34

[ "PUB00001055", "PUB00001622", "PUB00002771", "PUB00004011", "PUB00004020", "PUB00006577", "PUB00007779", "PUB00009378", "PUB00059153", "PUB00059154" ]

[ "1772658", "1879548", "1373731", "2448635", "2451788", "2555158", "11294861", "11178249", "12583903", "18620424" ]

[ "The molecular biology of K+ channels.", "Shaw-like rat brain potassium channel cDNA's with divergent 3' ends.", "Cloning, functional expression, and regulation of two K+ channels in human T lymphocytes.", "Multiple potassium-channel components are produced by alternative splicing at the Shaker locus in Droso...

[ 1991, 1991, 1992, 1988, 1988, 1989, 2001, 2000, 2003, 2008 ]

10

[]

[ "IPR005983", "IPR047628" ]

0

2

0

[ "Archaea", "Bacteria", "Eukaryota", "Siphoviridae sp. ctBLh2", "unclassified sequences" ]

[ 7, 17053, 10718, 1, 292 ]

5

[ "Arabidopsis thaliana", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Schizosaccharomyces pomb...

[ 2, 44, 9, 1, 32, 22, 1, 1, 18, 1, 7 ]

11

true

Family

Potassium channel, voltage-dependent, beta subunit, KCNAB-related

K_chnl_volt-dep_bsu_KCNAB-rel

9

IPR005400

5,400

Potassium channel, voltage-dependent, beta subunit, KCNAB1

K_chnl_volt-dep_bsu_KCNAB1

Family

3,090

false

Potassium channels are the most diverse group of the ion channel family [ , ]. They are important in shaping the action potential, and in neuronal excitability and plasticity [ ]. The potassium channel family is composed of several functionally distinct isoforms, which can be broadly separated into 2 groups [ ]: the pr...

[ "GO:0006813", "GO:0055085", "GO:0016020" ]

[ "potassium ion transport", "transmembrane transport", "membrane" ]

[ "biological_process", "biological_process", "cellular_component" ]

3

[ "PRINTS" ]

[ "PR01578" ]

[ "KCNAB1CHANEL" ]

[ 3090 ]

1

[ "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC"...

[ "1.1.1.-", "PWY-1121", "PWY-1186", "PWY-2541", "PWY-2601", "PWY-3162", "PWY-321", "PWY-3261", "PWY-3722", "PWY-5101", "PWY-5271", "PWY-5316", "PWY-5392", "PWY-5652", "PWY-5666", "PWY-5751", "PWY-5782", "PWY-5818", "PWY-5830", "PWY-5848", "PWY-5867", "PWY-5882", "PWY-5883"...

[ "EC:1.1.1.-", "METACYC:PWY-1121", "METACYC:PWY-1186", "METACYC:PWY-2541", "METACYC:PWY-2601", "METACYC:PWY-3162", "METACYC:PWY-321", "METACYC:PWY-3261", "METACYC:PWY-3722", "METACYC:PWY-5101", "METACYC:PWY-5271", "METACYC:PWY-5316", "METACYC:PWY-5392", "METACYC:PWY-5652", "METACYC:PWY-56...

154

[ "1exb", "1qrq", "1zsx", "2a79", "2r9r", "3eau", "3eb3", "3eb4", "3lnm", "4jta", "4jtc", "4jtd", "5wie", "6ci1", "6ebk", "6ebl", "7sit", "7siz", "7wf3", "7wf4" ]

20

[ "PUB00001055", "PUB00001622", "PUB00002771", "PUB00004011", "PUB00004020", "PUB00006577", "PUB00007778", "PUB00007779", "PUB00009378" ]

[ "1772658", "1879548", "1373731", "2448635", "2451788", "2555158", "10399921", "11294861", "11178249" ]

[ "The molecular biology of K+ channels.", "Shaw-like rat brain potassium channel cDNA's with divergent 3' ends.", "Cloning, functional expression, and regulation of two K+ channels in human T lymphocytes.", "Multiple potassium-channel components are produced by alternative splicing at the Shaker locus in Droso...

[ 1991, 1991, 1992, 1988, 1988, 1989, 1999, 2001, 2000 ]

9

[ "IPR005983" ]

[]

1

0

1

[ "Bacteria", "Eukaryota", "hydrothermal vent metagenome" ]

[ 3, 3086, 1 ]

3

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 24, 5, 9, 8, 1 ]

5

true

Family

Potassium channel, voltage-dependent, beta subunit, KCNAB1

K_chnl_volt-dep_bsu_KCNAB1

7

IPR005401

5,401

Potassium channel, voltage-dependent, beta subunit, KCNAB2

K_chnl_volt-dep_bsu_KCNAB2

Family

1,115

false

Potassium channels are the most diverse group of the ion channel family [ , ]. They are important in shaping the action potential, and in neuronal excitability and plasticity [ ]. The potassium channel family is composed of several functionally distinct isoforms, which can be broadly separated into 2 groups [ ]: the pr...

[ "GO:0005249", "GO:0006813", "GO:0016020" ]

[ "voltage-gated potassium channel activity", "potassium ion transport", "membrane" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PRINTS" ]

[ "PR01579" ]

[ "KCNAB2CHANEL" ]

[ 1115 ]

1

[ "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC"...

[ "1.1.1.-", "PWY-1121", "PWY-1186", "PWY-2541", "PWY-2601", "PWY-3162", "PWY-321", "PWY-3261", "PWY-3722", "PWY-5101", "PWY-5271", "PWY-5316", "PWY-5392", "PWY-5652", "PWY-5666", "PWY-5751", "PWY-5782", "PWY-5818", "PWY-5830", "PWY-5848", "PWY-5867", "PWY-5882", "PWY-5883"...

[ "EC:1.1.1.-", "METACYC:PWY-1121", "METACYC:PWY-1186", "METACYC:PWY-2541", "METACYC:PWY-2601", "METACYC:PWY-3162", "METACYC:PWY-321", "METACYC:PWY-3261", "METACYC:PWY-3722", "METACYC:PWY-5101", "METACYC:PWY-5271", "METACYC:PWY-5316", "METACYC:PWY-5392", "METACYC:PWY-5652", "METACYC:PWY-56...

156

[ "3lut", "7ej1", "7ej2" ]

3

[ "PUB00001055", "PUB00001622", "PUB00002771", "PUB00004011", "PUB00004020", "PUB00006577", "PUB00007779", "PUB00009378" ]

[ "1772658", "1879548", "1373731", "2448635", "2451788", "2555158", "11294861", "11178249" ]

[ "The molecular biology of K+ channels.", "Shaw-like rat brain potassium channel cDNA's with divergent 3' ends.", "Cloning, functional expression, and regulation of two K+ channels in human T lymphocytes.", "Multiple potassium-channel components are produced by alternative splicing at the Shaker locus in Droso...

[ 1991, 1991, 1992, 1988, 1988, 1989, 2001, 2000 ]

8

[ "IPR005983" ]

[]

1

0

1

[ "Vertebrata" ]

[ 1115 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 16, 24, 7, 5 ]

4

true

Family

Potassium channel, voltage-dependent, beta subunit, KCNAB2

K_chnl_volt-dep_bsu_KCNAB2

1

IPR005402

5,402

Potassium channel, voltage-dependent, beta subunit, KCNAB3

K_chnl_volt-dep_bsu_KCNAB3

Family

551

false

Potassium channels are the most diverse group of the ion channel family [ , ]. They are important in shaping the action potential, and in neuronal excitability and plasticity [ ]. The potassium channel family is composed of several functionally distinct isoforms, which can be broadly separated into 2 groups [ ]: the pr...

[ "GO:0005249", "GO:0006813", "GO:0016020" ]

[ "voltage-gated potassium channel activity", "potassium ion transport", "membrane" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PRINTS" ]

[ "PR01580" ]

[ "KCNAB3CHANEL" ]

[ 551 ]

1

[ "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC"...

[ "1.1.1.-", "PWY-1121", "PWY-1186", "PWY-2541", "PWY-2601", "PWY-3162", "PWY-321", "PWY-3261", "PWY-3722", "PWY-5101", "PWY-5271", "PWY-5316", "PWY-5392", "PWY-5652", "PWY-5666", "PWY-5751", "PWY-5782", "PWY-5818", "PWY-5830", "PWY-5848", "PWY-5867", "PWY-5882", "PWY-5883"...

[ "EC:1.1.1.-", "METACYC:PWY-1121", "METACYC:PWY-1186", "METACYC:PWY-2541", "METACYC:PWY-2601", "METACYC:PWY-3162", "METACYC:PWY-321", "METACYC:PWY-3261", "METACYC:PWY-3722", "METACYC:PWY-5101", "METACYC:PWY-5271", "METACYC:PWY-5316", "METACYC:PWY-5392", "METACYC:PWY-5652", "METACYC:PWY-56...

151

[]

0

[ "PUB00001055", "PUB00001622", "PUB00002771", "PUB00004011", "PUB00004020", "PUB00006577", "PUB00007779", "PUB00007780", "PUB00009378", "PUB00153719" ]

[ "1772658", "1879548", "1373731", "2448635", "2451788", "2555158", "11294861", "9857044", "11178249", "32990398" ]

[ "The molecular biology of K+ channels.", "Shaw-like rat brain potassium channel cDNA's with divergent 3' ends.", "Cloning, functional expression, and regulation of two K+ channels in human T lymphocytes.", "Multiple potassium-channel components are produced by alternative splicing at the Shaker locus in Droso...

[ 1991, 1991, 1992, 1988, 1988, 1989, 2001, 1998, 2000, 2020 ]

10

[ "IPR005983" ]

[]

1

0

1

[ "Chordata" ]

[ 551 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 3, 1, 5, 4 ]

4

true

Family

Potassium channel, voltage-dependent, beta subunit, KCNAB3

K_chnl_volt-dep_bsu_KCNAB3

5

IPR005403

5,403

Potassium channel, voltage dependent, Kv3.1

K_chnl_volt-dep_Kv3.1

Family

950

false

The Kv family can be divided into several subfamilies on the basis of sequence similarity and function. Four of these subfamilies, Kv1 (Shaker), Kv2 (Shab), Kv3 (Shaw) and Kv4 (Shal), consist of pore-forming alpha subunits that associate with different types of beta subunit. Each alpha subunit comprises six hydrophobic...

[ "GO:0005249", "GO:0006813", "GO:0016020" ]

[ "voltage-gated potassium channel activity", "potassium ion transport", "membrane" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PRINTS" ]

[ "PR01581" ]

[ "KV31CHANNEL" ]

[ 950 ]

1

[ "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-1296072", "R-MMU-1296072", "R-RNO-1296072" ]

[ "REACTOME:R-HSA-1296072", "REACTOME:R-MMU-1296072", "REACTOME:R-RNO-1296072" ]

3

[ "7phh", "7phi", "7phk", "7phl", "7pqt", "7pqu", "8f1c", "8f1d", "8quc", "8qud" ]

10

[ "PUB00001055", "PUB00001622", "PUB00002771", "PUB00004011", "PUB00004020", "PUB00006577", "PUB00008322", "PUB00009378", "PUB00009391", "PUB00154493" ]

[ "1772658", "1879548", "1373731", "2448635", "2451788", "2555158", "9305895", "11178249", "10712896", "35840580" ]

[ "The molecular biology of K+ channels.", "Shaw-like rat brain potassium channel cDNA's with divergent 3' ends.", "Cloning, functional expression, and regulation of two K+ channels in human T lymphocytes.", "Multiple potassium-channel components are produced by alternative splicing at the Shaker locus in Droso...

[ 1991, 1991, 1992, 1988, 1988, 1989, 1997, 2000, 2000, 2022 ]

10

[ "IPR003974" ]

[]

1

0

1

[ "Gnathostomata" ]

[ 950 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 3, 3, 3, 2 ]

4

true

Family

Potassium channel, voltage dependent, Kv3.1

K_chnl_volt-dep_Kv3.1

4

IPR005404

5,404

Potassium channel, voltage dependent, Kv3.3

K_chnl_volt-dep_Kv3.3

Family

356

false

Kv3.3 channels are evenly distributed over the soma and proximal apical dendrites. They have also been found in the lens epithelium, corneal endothelium, cerebellar cells and the deep cerebellar nuclei. When co-expressed with NADPH oxidase, they function as an oxygen sensor complex in airway chemoreceptors. A voltage-d...

[ "GO:0005249", "GO:0006813", "GO:0016020" ]

[ "voltage-gated potassium channel activity", "potassium ion transport", "membrane" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PRINTS" ]

[ "PR01582" ]

[ "KV33CHANNEL" ]

[ 356 ]

1

[ "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-1296072", "R-MMU-1296072", "R-RNO-1296072" ]

[ "REACTOME:R-HSA-1296072", "REACTOME:R-MMU-1296072", "REACTOME:R-RNO-1296072" ]

3

[]

0

[ "PUB00001055", "PUB00001622", "PUB00002771", "PUB00004011", "PUB00004020", "PUB00006577", "PUB00008322", "PUB00009378", "PUB00009391" ]

[ "1772658", "1879548", "1373731", "2448635", "2451788", "2555158", "9305895", "11178249", "10712896" ]

[ "The molecular biology of K+ channels.", "Shaw-like rat brain potassium channel cDNA's with divergent 3' ends.", "Cloning, functional expression, and regulation of two K+ channels in human T lymphocytes.", "Multiple potassium-channel components are produced by alternative splicing at the Shaker locus in Droso...

[ 1991, 1991, 1992, 1988, 1988, 1989, 1997, 2000, 2000 ]

9

[ "IPR003974" ]

[]

1

0

1

[ "Bacteria", "Eukaryota" ]

[ 2, 354 ]

2

[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 4, 5, 10 ]

3

true

Family

Potassium channel, voltage dependent, Kv3.3

K_chnl_volt-dep_Kv3.3

6

IPR005405

5,405

Potassium channel, voltage dependent, Kv3.4

K_chnl_volt-dep_Kv3.4

Family

1,020

false

Kv3.4 channels are expressed in cells that surround the cerebellar Purkinje cells. In the presence of protein kinase C, rapid inactivation is eliminated, resulting in a non-inactivating delayed rectifying current. The implications of this are seen for signal encoding in the central nervous system. The Kv family can be ...

[ "GO:0005249", "GO:0006813", "GO:0016020" ]

[ "voltage-gated potassium channel activity", "potassium ion transport", "membrane" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PRINTS" ]

[ "PR01583" ]

[ "KV34CHANNEL" ]

[ 1020 ]

1

[ "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-1296072", "R-MMU-1296072", "R-RNO-1296072" ]

[ "REACTOME:R-HSA-1296072", "REACTOME:R-MMU-1296072", "REACTOME:R-RNO-1296072" ]

3

[]

0

[ "PUB00001055", "PUB00001622", "PUB00002771", "PUB00004011", "PUB00004020", "PUB00006577", "PUB00008322", "PUB00009378", "PUB00009391" ]

[ "1772658", "1879548", "1373731", "2448635", "2451788", "2555158", "9305895", "11178249", "10712896" ]

[ "The molecular biology of K+ channels.", "Shaw-like rat brain potassium channel cDNA's with divergent 3' ends.", "Cloning, functional expression, and regulation of two K+ channels in human T lymphocytes.", "Multiple potassium-channel components are produced by alternative splicing at the Shaker locus in Droso...

[ 1991, 1991, 1992, 1988, 1988, 1989, 1997, 2000, 2000 ]

9

[ "IPR003974" ]

[]

1

0

1

[ "Eukaryota" ]

[ 1020 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 3, 2, 2, 4 ]

4

true

Family

Potassium channel, voltage dependent, Kv3.4

K_chnl_volt-dep_Kv3.4

1