LiteFold/InterPro · Datasets at Hugging Face

IPR054818

54,818

Variant surface antigen A, N-terminal region

VlpA_N

Domain

4

false

This entry represents the N-terminal region of the highly repetitive surface antigen VlpA (variant lipoprotein A) of Mycoplasma hyorhinis, a pig pathogen, and similar sequences.

[]

0

[ "NCBIFAM" ]

[ "NF045729" ]

[ "VlpA_Nterm" ]

[ 4 ]

1

[]

0

[]

0

[ "PUB00154762" ]

[ "34954543" ]

[ "The variable lipoprotein family participates in the interaction of Mycoplasma hyorhinis with host extracellular matrix and plasminogen." ]

[ 2022 ]

1

[]

0

null

[ "Mesomycoplasma hyorhinis" ]

[ 4 ]

1

[]

0

true

Domain

Variant surface antigen A, N-terminal region

VlpA_N

3

IPR054819

54,819

Variant surface antigen C, N-terminal region

VlpC_N

Domain

4

false

This entry represents the N-terminal region of the highly repetitive surface antigen VlpC (variant lipoprotein C) of Mycoplasma hyorhinis, a pig pathogen.

[]

0

[ "NCBIFAM" ]

[ "NF045730" ]

[ "VlpC_Nterm" ]

[ 4 ]

1

[]

0

[]

0

[ "PUB00154762" ]

[ "34954543" ]

[ "The variable lipoprotein family participates in the interaction of Mycoplasma hyorhinis with host extracellular matrix and plasminogen." ]

[ 2022 ]

1

[ "IPR049890" ]

[]

1

0

1

[ "Mesomycoplasma hyorhinis" ]

[ 4 ]

1

[]

0

true

Domain

Variant surface antigen C, N-terminal region

VlpC_N

8

IPR054820

54,820

MPN555 chaperone-like

MPN555-like

Family

39

false

This entry includes MNP55 from Mycoplasma pneumoniae, also known as MG377 homolog. According to structural homology, this protein may be involved in protein folding as a molecular chaperone [ ].

[]

0

[ "NCBIFAM" ]

[ "NF045756" ]

[ "MPN555" ]

[ 39 ]

1

[]

0

[ "1zxj" ]

1

[ "PUB00039059", "PUB00154763", "PUB00154765" ]

[ "16204885", "22373819", "32732422" ]

[ "Structure of the hypothetical Mycoplasma protein MPN555 suggests a chaperone function.", "Cross-talk between phosphorylation and lysine acetylation in a genome-reduced bacterium.", "In-cell architecture of an actively transcribing-translating expressome." ]

[ 2005, 2012, 2020 ]

3

[]

0

null

[ "Mycoplasmatota" ]

[ 39 ]

1

[]

0

true

Family

MPN555 chaperone-like

MPN555-like

4

IPR054821

54,821

Transcciptional activator PmfR

Trans_act_PmfR

Family

4

false

This family includes transcriptional activator PmfR, a transcriptional regulator involved in the activation of the purU-mabO-folD-nepA-nepB and mao-ORF55-nbr operons implicated in the nicotine catabolic pathway. The sequence GTTT-14 bp-AAAC seems to be the core binding site of the regulator upstream of the -35 promoter...

[]

0

[ "NCBIFAM" ]

[ "NF045769" ]

[ "TransActPmfR" ]

[ 4 ]

1

[]

0

[]

0

[ "PUB00154649", "PUB00154650", "PUB00154866" ]

[ "17293530", "15838033", "17464069" ]

[ "An NAD(P)H-nicotine blue oxidoreductase is part of the nicotine regulon and may protect Arthrobacter nicotinovorans from oxidative stress during nicotine catabolism.", "Characterization of PmfR, the transcriptional activator of the pAO1-borne purU-mabO-folD operon of Arthrobacter nicotinovorans.", "A two-compo...

[ 2007, 2005, 2007 ]

3

[]

0

null

[ "Micrococcaceae" ]

[ 4 ]

1

[]

0

true

Family

Transcciptional activator PmfR

Trans_act_PmfR

7

IPR054822

54,822

Sulfate reduction electron transfer complex DsrMKJOP subunit DsrO-like

DsrO-like

Family

1,933

false

This family represents a group of prokaryotic members of the DsrMKJOP dissimilatory sulfate reduction complex that contain an iron-sulphur binding domain ( ), including subunit DsrO from Desulfovibrio desulfuricans ( ), a periplasmic FeS protein. This membrane-bound redox complex is involved in sulfate reduction in sul...

[]

0

[ "NCBIFAM" ]

[ "NF045797" ]

[ "DsrO" ]

[ 1933 ]

1

[]

0

[]

0

[ "PUB00088715", "PUB00105534", "PUB00109129", "PUB00154667", "PUB00154668" ]

[ "15009189", "16388601", "11952791", "21747791", "38285932" ]

[ "Two distinct heterodisulfide reductase-like enzymes in the sulfate-reducing archaeon Archaeoglobus profundus.", "Characterization of the Desulfovibrio desulfuricans ATCC 27774 DsrMKJOP complex--a membrane-bound redox complex involved in the sulfate respiratory pathway.", "Purification and characterization of a...

[ 2004, 2006, 2002, 2011, 2024 ]

5

[]

0

null

[ "Archaea", "Bacteria", "Ecdysozoa", "unclassified sequences" ]

[ 78, 1787, 2, 66 ]

4

[]

0

true

Family

Sulfate reduction electron transfer complex DsrMKJOP subunit DsrO-like

DsrO-like

9

IPR054823

54,823

Sulfate reduction electron transfer complex DsrMKJOP subunit DsrP-like

DsrP-like

Family

520

false

This family represents a group of prokaryotic proteins, including the DsrP subunit of the DsrMKJOP dissimilatory sulfate reduction complex from Desulfovibrio desulfuricans ( ), a highly hydrophobic protein [ ].

[]

0

[ "NCBIFAM" ]

[ "NF045798" ]

[ "DsrP" ]

[ 520 ]

1

[]

0

[]

0

[ "PUB00105534", "PUB00154668" ]

[ "16388601", "38285932" ]

[ "Characterization of the Desulfovibrio desulfuricans ATCC 27774 DsrMKJOP complex--a membrane-bound redox complex involved in the sulfate respiratory pathway.", "DsrMKJOP is the terminal reductase complex in anaerobic sulfate respiration." ]

[ 2006, 2024 ]

2

[ "IPR005614" ]

[]

1

0

1

[ "Archaeoglobus sulfaticallidus PM70-1", "Bacteria", "ecological metagenomes" ]

[ 1, 502, 17 ]

3

[]

0

true

Family

Sulfate reduction electron transfer complex DsrMKJOP subunit DsrP-like

DsrP-like

8

IPR054824

54,824

Gas vesicle protein GvpO-like, N-terminal domain

GvpO-like_N

Domain

97

false

This entry represents the N-terminal domain of gas vesicle protein GvpO sequences from halobacteria. It is around 35-amino acids long and has three invariant Cys residues.

[]

0

[ "NCBIFAM" ]

[ "NF045806" ]

[ "GvpO_arch_Nterm" ]

[ 97 ]

1

[]

0

[]

0

[]

0

[ "IPR043914" ]

[]

1

0

1

[ "Halobacteriales" ]

[ 97 ]

1

[]

0

true

Domain

Gas vesicle protein GvpO-like, N-terminal domain

GvpO-like_N

9

IPR054825

54,825

Surface lipoprotein P68-like

P68-like

Family

376

false

This entry represents a group of proteins from Mycoplasmatota, including P68 from Mesomycoplasma hyopneumoniae ( , Mhp390, a membrane-associated lipoprotein). P68 plays an important role in binding to swine tracheal cilia. It contributes to the production of proinflammatory cytokines and could induce significant apopto...

[]

0

[ "NCBIFAM" ]

[ "NF045826" ]

[ "lipo_P68" ]

[ 376 ]

1

[]

0

[]

0

[ "PUB00154764", "PUB00154802", "PUB00154804" ]

[ "23297388", "35873172", "30385395" ]

[ "Implication of glycerol and phospholipid transporters in Mycoplasma pneumoniae growth and virulence.", "Mycoplasma hyopneumoniae Infection Activates the NOD1 Signaling Pathway to Modulate Inflammation.", "Surface proteins mhp390 (P68) contributes to cilium adherence and mediates inflammation and apoptos...

[ 2013, 2022, 2019 ]

3

[]

0

null

[ "Mycoplasmatota", "Vespula germanica" ]

[ 375, 1 ]

2

[]

0

true

Family

Surface lipoprotein P68-like

P68-like

4

IPR054826

54,826

Thiol peroxidase Prx-SUH

Perox_SUH

Family

62

false

This entry represents a group of thiol peroxidases Prx from Epsilonproteobacteria in which the last six amino acids are typically CCGXCH or CCGSUH, where U is selenocysteine. The function if this C-terminal hexapeptide region is not yet well understood [ ].

[]

0

[ "NCBIFAM" ]

[ "NF045827" ]

[ "perox_SUH" ]

[ 62 ]

1

[]

0

[]

0

[ "PUB00081206" ]

[ "26342139" ]

[ "Evolution of the Selenoproteome in Helicobacter pylori and Epsilonproteobacteria." ]

[ 2015 ]

1

[ "IPR002065" ]

[]

1

0

1

[ "Campylobacterales", "bioreactor metagenome" ]

[ 61, 1 ]

2

[]

0

true

Family

Thiol peroxidase Prx-SUH

Perox_SUH

7

IPR054827

54,827

TCP-1 chaperonin-like

TCP-1-like

Family

30,241

true

This entry represents members of the TCP-1 chaperonin family, which includes Chaperonin and T-complex protein 1 (TCP1) subunits. These proteins function as molecular chaperones, assisting in the folding of proteins upon ATP hydrolysis. The Chaperonin subunits, found in archaea, bind unfolded polypeptides and have weak ...

[]

0

[ "NCBIFAM", "NCBIFAM" ]

[ "NF041082", "NF041083" ]

[ "thermosome_alpha", "TCP-1_chaperonin" ]

[ 23064, 30221 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-390471", "R-BTA-6798695", "R-BTA-6814122", "R-BTA-9013418", "R-BTA-9013422", "R-CEL-390471", "R-CEL-6798695", "R-CEL-6814122", "R-DDI-390471", "R-DDI-6798695", "R-DDI-6814122", "R-DDI-9013418", "R-DDI-9013422", "R-DME-390471", "R-DME-6814122", "R-GGA-390471", "R-GGA-6814122", ...

[ "REACTOME:R-BTA-390471", "REACTOME:R-BTA-6798695", "REACTOME:R-BTA-6814122", "REACTOME:R-BTA-9013418", "REACTOME:R-BTA-9013422", "REACTOME:R-CEL-390471", "REACTOME:R-CEL-6798695", "REACTOME:R-CEL-6814122", "REACTOME:R-DDI-390471", "REACTOME:R-DDI-6798695", "REACTOME:R-DDI-6814122", "REACTOME:R...

44

[ "1a6d", "1a6e", "1q2v", "1q3q", "1q3r", "1q3s", "3aq1", "3iyg", "3izh", "3izi", "3izj", "3izm", "3j1b", "3j1c", "3j1e", "3j1f", "3j3x", "3kfb", "3ko1", "3ktt", "3los", "3ruq", "3rus", "3ruv", "3ruw", "4a0o", "4a0v", "4a0w", "4a13", "4b2t", "4v81", "4v8r"...

124

[ "PUB00106164", "PUB00106165", "PUB00106166" ]

[ "10508614", "7867646", "9023959" ]

[ "Recurrent paralogy in the evolution of archaeal chaperonins.", "The thermosome of Thermoplasma acidophilum and its relationship to the eukaryotic chaperonin TRiC.", "In vitro stabilization and in vivo solubilization of foreign proteins by the beta subunit of a chaperonin from the hyperthermophilic archaeon Pyr...

[ 1999, 1995, 1997 ]

3

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences", "uncultured virus" ]

[ 2367, 3, 27803, 64, 4 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 22, 6, 7, 11, 30, 30, 7, 20, 22, 5, 7, 46 ]

12

true

Family

TCP-1 chaperonin-like

TCP-1-like

2

IPR054828

54,828

Vitamin B12-binding protein

Vit_B12_bind_prot

Family

14,633

true

false

This entry represents the Vitamin B12-binding protein, also known as the Cobalamin-binding protein or BtuF family protein. These proteins are part of the ABC transporter complex BtuCDF involved in the import of vitamin B12 (cobalamin). They bind vitamin B12 and deliver it to the periplasmic surface of BtuC. The functio...

[]

0

[ "NCBIFAM" ]

[ "NF038402" ]

[ "Vit_B12_bind_prot" ]

[ 14633 ]

1

[]

0

[ "1n2z", "1n4a", "1n4d", "2qi9", "4dbl", "4fi3", "4m7o", "5b58", "5giz", "5m29", "5m2q", "5m34", "5m3b", "5ovw", "5y89", "5y8a", "5ysc" ]

17

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 612, 13783, 10, 228 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Vitamin B12-binding protein

Vit_B12_bind_prot

4

IPR054829

54,829

Ferredoxin-1

FdxA

Family

7,580

true

false

Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. These proteins are found in various bacterial species including Pseudomonas aeruginosa, Pseudomonas putida, Rickettsia prowazekii, Rickettsia bellii, Rhodobacter capsulatus, Azotobacter vinelandii, Stutzerimonas stutz...

[]

0

[ "NCBIFAM" ]

[ "NF045490" ]

[ "FdxA" ]

[ 7580 ]

1

[]

0

[ "1a6l", "1axq", "1b0t", "1b0v", "1d3w", "1f5b", "1f5c", "1fd2", "1fda", "1fdb", "1fdd", "1fer", "1ff2", "1frh", "1fri", "1frj", "1frk", "1frl", "1frm", "1frx", "1ftc", "1g3o", "1g6b", "1gao", "1pc4", "1pc5", "2fd2", "5fd1", "6fd1", "6fdr", "7fd1", "7fdr"...

32

[ "PUB00021173", "PUB00153553", "PUB00153554" ]

[ "10593945", "2388848", "7751303" ]

[ "Alteration of the reduction potential of the [4Fe-4S](2+/+) cluster of Azotobacter vinelandii ferredoxin I.", "Nucleotide sequence of fdxA encoding a 7Fe ferredoxin of Rhodobacter capsulatus.", "Synthesis of the Caulobacter ferredoxin protein, FdxA, is cell cycle controlled." ]

[ 1999, 1990, 1995 ]

3

[]

0

null

[ "Bacteria", "Opisthokonta", "unclassified sequences", "uncultured Caudovirales phage" ]

[ 7463, 6, 110, 1 ]

4

[]

0

true

Family

Ferredoxin-1

FdxA

6

IPR054830

54,830

Ferredoxin

FdxA_Actino

Family

6,092

true

false

Ferredoxins are iron-sulfur proteins that play a crucial role in electron transfer across a variety of metabolic reactions. These proteins are characterized by their ability to transfer electrons, which is essential for numerous biochemical processes. The ferredoxins described here are found in various Actinobacteria, ...

[]

0

[ "NCBIFAM" ]

[ "NF045480" ]

[ "FdxA_Actino" ]

[ 6092 ]

1

[ "REACTOME" ]

[ "R-MTU-936721" ]

[ "REACTOME:R-MTU-936721" ]

1

[ "2v2k" ]

1

[ "PUB00153550" ]

[ "2055472" ]

[ "Cloning and characterization of the Saccharopolyspora erythraea fdxA gene encoding ferredoxin." ]

[ 1991 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 5970, 2, 120 ]

3

[]

0

true

Family

Ferredoxin

FdxA_Actino

6

IPR054831

54,831

UPF0122 family protein

UPF0122_fam_protein

Family

4,538

true

false

The UPF0122 family proteins are a group of conserved proteins that are believed to be involved in the signal recognition particle (SRP) pathway. This inference is based on the conservation of their genetic proximity to ftsY/ffh genes, which are key components of the SRP pathway. The exact function of these proteins is ...

[]

0

[ "NCBIFAM" ]

[ "NF045758" ]

[ "UPF0122_fam_protein" ]

[ 4538 ]

1

[]

0

[ "1s7o", "1xsv" ]

2

[ "PUB00154737", "PUB00154738" ]

[ "31445891", "24659773" ]

[ "Determination of the Gene Regulatory Network of a Genome-Reduced Bacterium Highlights Alternative Regulation Independent of Transcription Factors.", "YlxM is a newly identified accessory protein that influences the function of signal recognition particle pathway components in Streptococcus mutans." ]

[ 2019, 2014 ]

2

[]

0

null

[ "Bacteria", "Opisthokonta", "Siphoviridae sp. ctDiR9", "metagenomes" ]

[ 4505, 2, 1, 30 ]

4

[]

0

true

Family

UPF0122 family protein

UPF0122_fam_protein

7

IPR054832

54,832

Transposase IS91-like

Transpos_IS91

Family

4,468

true

The IS91 family transposase is involved in the transposition of insertion sequence elements [ ]. Members of this family are found in various bacterial species, including Pseudomonas savastanoi pv. phaseolicola and Sinorhizobium americanum. These transposases belong to the transposase 32 family and play a crucial role i...

[]

0

[ "NCBIFAM" ]

[ "NF033538" ]

[ "transpos_IS91" ]

[ 4468 ]

1

[]

0

[]

0

[ "PUB00162882" ]

[ "20625149" ]

[ "Structural characterization of ISCR8, ISCR22, and ISCR23, subgroups of IS91-like insertion elements." ]

[ 2010 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "Methanomicrobia", "unclassified sequences" ]

[ 4322, 15, 20, 111 ]

4

[]

0

true

Family

Transposase IS91-like

Transpos_IS91

7

IPR054833

54,833

Acetamidase/formamidase family

FormamaseFmdA

Family

4,141

true

false

This entry represents formamidases, which are enzymes that hydrolyze formamide to produce ammonia, which can be used as a nitrogen source for growth. These enzymes may also act on other amides such as acetamide, propanamide, and butanamide, albeit more slowly. Members of this family include the putative formamidase C86...

[]

0

[ "NCBIFAM" ]

[ "NF045496" ]

[ "FormamaseFmdA" ]

[ 4141 ]

1

[]

0

[ "2wkn" ]

1

[ "PUB00020777" ]

[ "8841393" ]

[ "Molecular characterisation of formamidase from Methylophilus methylotrophus." ]

[ 1996 ]

1

[]

0

null

[ "Bacteria", "Catovirus CTV1", "Eukaryota", "Halobacteriales", "metagenomes" ]

[ 2179, 1, 1864, 82, 15 ]

5

[ "Arabidopsis thaliana", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)", "Zea mays" ]

[ 16, 2, 3, 1, 6 ]

5

true

Family

Acetamidase/formamidase family

FormamaseFmdA

8

IPR054834

54,834

Small archaeal modifier protein 1/3

SAMP1_3

Family

1,887

true

false

Small archaeal modifier proteins 1 and 3 (SAMP1 and SAMP3) from Haloferax volcanii function as protein modifiers covalently attached to lysine residues of substrate proteins. This modification process, termed sampylation, involves the formation of an isopeptide bond between the C-terminal glycine carboxylate of SAMP pr...

[]

0

[ "NCBIFAM" ]

[ "NF041918" ]

[ "SAMP1_3" ]

[ 1887 ]

1

[]

0

[ "1v8c", "1vjk", "2g1e", "2k22", "2l52", "2l83", "2m19", "3po0", "4hro" ]

9

[ "PUB00058155", "PUB00138936" ]

[ "20054389", "21216237" ]

[ "Ubiquitin-like small archaeal modifier proteins (SAMPs) in Haloferax volcanii.", "Crystal structure of ubiquitin-like small archaeal modifier protein 1 (SAMP1) from Haloferax volcanii." ]

[ 2010, 2011 ]

2

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "ecological metagenomes" ]

[ 964, 856, 8, 59 ]

4

[]

0

true

Family

Small archaeal modifier protein 1/3

SAMP1_3

8

IPR054835

54,835

ArsJ-associated glyceraldehyde-3-phosphate dehydrogenase

G3PDH_Arsen

Family

2,534

true

false

This entry represents ArsJ-associated glyceraldehyde-3-phosphate dehydrogenase (GAPDH 3), an enzyme that catalyzes the oxidative phosphorylation of glyceraldehyde 3-phosphate (G3P) to 1,3-bisphosphoglycerate (BPG) using the cofactor NAD. The reaction involves the formation of a hemiacetal intermediate between G3P and a...

[]

0

[ "NCBIFAM" ]

[ "NF033735" ]

[ "G3PDH_Arsen" ]

[ 2534 ]

1

[]

0

[]

0

[ "PUB00105284" ]

[ "26991003" ]

[ "Synergistic interaction of glyceraldehydes-3-phosphate dehydrogenase and ArsJ, a novel organoarsenical efflux permease, confers arsenate resistance." ]

[ 2016 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "ecological metagenomes" ]

[ 2422, 75, 37 ]

3

[]

0

true

Family

ArsJ-associated glyceraldehyde-3-phosphate dehydrogenase

G3PDH_Arsen

3

IPR054836

54,836

Transposase for transposon Tn5

Tn5_transposase

Family

1,851

true

false

This entry represents the transposase for transposon Tn5, a protein that mediates the transposition of the Tn5 transposon in Escherichia coli. The transposase operates via a 'cut and paste' mechanism. Initially, the monomeric transposase binds to the 19 bp inverted DNA repeats flanking the transposon. Dimerization of t...

[]

0

[ "NCBIFAM" ]

[ "NF033590" ]

[ "Tn5_transposase" ]

[ 1851 ]

1

[]

0

[ "1b7e", "1mm8", "1muh", "1mus", "3ecp", "4dm0" ]

6

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Methanobacteriota", "ecological metagenomes", "plasmids" ]

[ 1768, 13, 35, 33, 2 ]

5

[]

0

true

Family

Transposase for transposon Tn5

Tn5_transposase

7

IPR054837

54,837

Galactofuranose ABC transporter, galactofuranose-binding protein YtfQ

YtfQ_transport

Family

1,399

true

false

This entry represents the galactofuranose-binding protein YtfQ, which is part of the ABC transporter complex YtfQRT-YjfF involved in galactofuranose transport in Escherichia coli (strain K12). YtfQ binds to both alpha- and beta-galactofuranose. It belongs to the bacterial solute-binding protein 2 family.

[]

0

[ "NCBIFAM" ]

[ "NF041827" ]

[ "YtfQ_transport" ]

[ 1399 ]

1

[]

0

[ "2vk2" ]

1

[ "PUB00152883" ]

[ "30698741" ]

[ "The y-ome defines the 35% of Escherichia coli genes that lack experimental evidence of function." ]

[ 2019 ]

1

[]

0

null

[ "Bacteria", "Trichuris trichiura", "human gut metagenome" ]

[ 1397, 1, 1 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Galactofuranose ABC transporter, galactofuranose-binding protein YtfQ

YtfQ_transport

8

IPR054838

54,838

Adenylyltransferase SelO

adnlytase_SelO

Family

1,214

true

false

Protein adenylyltransferase SelO is an enzyme that catalyzes the transfer of adenosine 5'-monophosphate (AMP) to serine, threonine, or tyrosine residues of target proteins, a process known as AMPylation. This enzyme belongs to the SELO family and is found in various bacterial species, including Escherichia coli and Sal...

[]

0

[ "NCBIFAM" ]

[ "NF040880" ]

[ "adnlytase_SelO" ]

[ 1214 ]

1

[ "EC", "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC" ]

[ "2.7.7.-", "2.7.7.108", "PWY-6322", "PWY-6626", "PWY-6749", "PWY-6955", "PWY-6998", "PWY-7127", "PWY-7419", "PWY-7529", "PWY-7706", "PWY-7719", "PWY-7735", "PWY-7737", "PWY-7769", "PWY-7888", "PWY-7904", "PWY-8117", "PWY-8179" ]

[ "EC:2.7.7.-", "EC:2.7.7.108", "METACYC:PWY-6322", "METACYC:PWY-6626", "METACYC:PWY-6749", "METACYC:PWY-6955", "METACYC:PWY-6998", "METACYC:PWY-7127", "METACYC:PWY-7419", "METACYC:PWY-7529", "METACYC:PWY-7706", "METACYC:PWY-7719", "METACYC:PWY-7735", "METACYC:PWY-7737", "METACYC:PWY-7769"...

19

[ "6iii", "6iny", "6k20", "6lna" ]

4

[ "PUB00092455" ]

[ "30270044" ]

[ "Protein AMPylation by an Evolutionarily Conserved Pseudokinase." ]

[ 2018 ]

1

[]

0

null

[ "Gammaproteobacteria" ]

[ 1214 ]

1

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Adenylyltransferase SelO

adnlytase_SelO

8

IPR054839

54,839

Photosynthetic complex putative assembly protein PuhB

puhB_PGC

Family

639

true

false

This entry represents the photosynthetic complex putative assembly protein PuhB. The protein is involved in the assembly of photosynthetic complexes, which are crucial for the photosynthetic process in organisms such as Rhodobacter capsulatus. The exact function of PuhB remains to be fully characterized, but it is beli...

[]

0

[ "NCBIFAM" ]

[ "NF040894" ]

[ "puhB_PGC" ]

[ 639 ]

1

[]

0

[]

0

[ "PUB00106049" ]

[ "29795276" ]

[ "Horizontal operon transfer, plasmids, and the evolution of photosynthesis in Rhodobacteraceae." ]

[ 2018 ]

1

[]

0

null

[ "Pseudomonadati", "Symbiodinium necroappetens", "freshwater sediment metagenome" ]

[ 637, 1, 1 ]

3

[]

0

true

Family

Photosynthetic complex putative assembly protein PuhB

puhB_PGC

1

IPR054840

54,840

1-hydroxy-gamma-carotene desaturase

hydcarot_desat_CrtD

Family

619

true

false

This entry represents 1-hydroxycarotenoid 3,4-desaturase, an enzyme that catalyzes the introduction of a C-3,4 double bond into 1'-hydroxy-gamma-carotene and rhodopin (1-hydroxylycopene) to yield 1'-hydroxytorulene and (3E)-3,4-didehydrorhodopin, respectively. It can also act on 1-hydroxy-all-trans-1,2-dihydro-neurospo...

[]

0

[ "NCBIFAM" ]

[ "NF042421" ]

[ "hydcarot_desat_CrtD" ]

[ 619 ]

1

[]

0

[ "4rep" ]

1

[ "PUB00153527", "PUB00153528" ]

[ "26138397", "15251462" ]

[ "Crystal structure of 1'-OH-carotenoid 3,4-desaturase from Nonlabens dokdonensis DSW-6.", "1-Hydroxy monocyclic carotenoid 3,4-dehydrogenase from a marine bacterium that produces myxol." ]

[ 2015, 2004 ]

2

[]

0

null

[ "Pseudomonadati", "ecological metagenomes" ]

[ 616, 3 ]

2

[]

0

true

Family

1-hydroxy-gamma-carotene desaturase

hydcarot_desat_CrtD

1

IPR054841

54,841

1-hydroxycarotenoid 3,4-desaturase

carotdesatCrtD

Family

636

true

false

This entry represents the 1-hydroxycarotenoid 3,4-desaturase (CrtD), which belongs to the carotenoid/retinoid oxidoreductase family. The enzyme catalyzes the introduction of C-3,4 double bonds into 1-hydroxyneurosporene (1-HO-Neu) to yield demethylspheroidene (DMS). The preferred substrates for this enzyme include 1-hy...

[]

0

[ "NCBIFAM" ]

[ "NF045637" ]

[ "carotdesatCrtD" ]

[ 636 ]

1

[ "EC", "METACYC", "METACYC" ]

[ "1.3.99.27", "PWY-6581", "PWY-7947" ]

[ "EC:1.3.99.27", "METACYC:PWY-6581", "METACYC:PWY-7947" ]

3

[]

0

[ "PUB00154721", "PUB00154722" ]

[ "10880364", "9393712" ]

[ "Substrate specificity of the expressed carotenoid 3,4-desaturase from Rubrivivax gelatinosus reveals the detailed reaction sequence to spheroidene and spirilloxanthin.", "Purification and biochemical characterization of a hydroxyneurosporene desaturase involved in the biosynthetic pathway of the carotenoid spher...

[ 2000, 1997 ]

2

[]

0

null

[ "Bacteria", "freshwater sediment metagenome" ]

[ 635, 1 ]

2

[]

0

true

Family

1-hydroxycarotenoid 3,4-desaturase

carotdesatCrtD

9

IPR054842

54,842

Probable dimethyl sulfoxide reductase chain YnfF

DMSO_reductase_YnfF

Family

935

true

false

The protein YnfF from Escherichia coli (strain K12) is a probable dimethyl sulfoxide (DMSO) reductase chain. It functions as a terminal reductase during anaerobic growth on various sulfoxide and N-oxide compounds. YnfF is also annotated as a selenate/tellurate reductase subunit. This protein belongs to the prokaryotic ...

[]

0

[ "NCBIFAM" ]

[ "NF041884" ]

[ "DMSO_reductase_YnfF" ]

[ 935 ]

1

[]

0

[]

0

[ "PUB00034653", "PUB00152968" ]

[ "14522592", "33136147" ]

[ "The Escherichia coli ynfEFGHI operon encodes polypeptides which are paralogues of dimethyl sulfoxide reductase (DmsABC).", "Genetic analysis of tellurate reduction reveals the selenate/tellurate reductase genes ynfEF and the transcriptional regulation of moeA by NsrR in Escherichia coli." ]

[ 2003, 2021 ]

2

[]

0

null

[ "Gammaproteobacteria" ]

[ 935 ]

1

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Probable dimethyl sulfoxide reductase chain YnfF

DMSO_reductase_YnfF

4

IPR054843

54,843

Slam-dependent hemophilin, C-terminal domain

Slam_hemophilin_C

Domain

820

false

This entry represents the C-terminal domain of Slam-dependent hemophilins found in Acinetobacter baumannii, Haemophilus influenzae and related Gram-negative bacteria, which consists of a β-barrel. Hemophilins are part of a high affinity heme acquisition system [ , , ]. It functions as a hemophore that acquires heme fro...

[]

0

[ "NCBIFAM" ]

[ "NF041636" ]

[ "slam_lipo" ]

[ 820 ]

1

[]

0

[ "5ee2", "6om5", "7re4", "7rea", "7red", "8glo", "8gm3", "8gmm" ]

8

[ "PUB00095100", "PUB00154014", "PUB00155018" ]

[ "28620585", "34725337", "38814789" ]

[ "Identification of a Large Family of Slam-Dependent Surface Lipoproteins in Gram-Negative Bacteria.", "A Slam-dependent hemophore contributes to heme acquisition in the bacterial pathogen Acinetobacter baumannii.", "Prevalence of Slam-dependent hemophilins in Gram-negative bacteria." ]

[ 2017, 2021, 2024 ]

3

[]

[ "IPR054536" ]

0

1

0

[ "Bacteria", "Opisthokonta", "marine sediment metagenome" ]

[ 815, 3, 2 ]

3

[]

0

true

Domain

Slam-dependent hemophilin, C-terminal domain

Slam_hemophilin_C

6

IPR054844

54,844

HTH-type transcriptional regulator BhcR

TransRegBhcR

Family

537

true

false

HTH-type transcriptional regulator BhcR is a protein found in Paracoccus denitrificans (strain Pd 1222). It functions as a transcriptional regulator of the bhc gene cluster, which is involved in glycolate and glyoxylate assimilation via the beta-hydroxyaspartate cycle (BHAC). The interaction of BhcR with the promoter r...

[]

0

[ "NCBIFAM" ]

[ "NF045644" ]

[ "TransRegBhcR" ]

[ 537 ]

1

[]

0

[]

0

[ "PUB00154623" ]

[ "31723261" ]

[ "Marine Proteobacteria metabolize glycolate via the β-hydroxyaspartate cycle." ]

[ 2019 ]

1

[]

0

null

[ "Pseudomonadota", "ecological metagenomes" ]

[ 532, 5 ]

2

[]

0

true

Family

HTH-type transcriptional regulator BhcR

TransRegBhcR

3

IPR054845

54,845

CsxC family protein

Exosporium_prot_C

Family

857

true

false

Exosporium protein C (CsxC) is a protein found in Clostridium sporogenes (strain ATCC 15579). It is part of the CsxC family, which is characterized by its role in the exosporium, a protective layer surrounding the spore. The CsxC family proteins are involved in the formation and maintenance of this layer, which is cruc...

[]

0

[ "NCBIFAM" ]

[ "NF045794" ]

[ "Exosporium_prot_C" ]

[ 857 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacillota", "bioreactor metagenome" ]

[ 854, 3 ]

2

[]

0

true

Family

CsxC family protein

Exosporium_prot_C

2

IPR054847

54,847

Reactive chlorine resistance oxidoreductase RclA

chlor_oxi_RclA

Family

793

true

false

Reactive chlorine resistance oxidoreductase RclA is a probable pyridine nucleotide-disulfide oxidoreductase found in Escherichia coli (strain K12). It belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family and is likely involved in reactive chlorine species (RCS) stress resistance. This enzyme plays...

[]

0

[ "NCBIFAM" ]

[ "NF040477" ]

[ "chlor_oxi_RclA" ]

[ 793 ]

1

[]

0

[ "6kgy", "6kod", "6kyy" ]

3

[ "PUB00085116" ]

[ "24078635" ]

[ "The RclR protein is a reactive chlorine-specific transcription factor in Escherichia coli." ]

[ 2013 ]

1

[]

0

null

[ "Pseudomonadota" ]

[ 793 ]

1

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Reactive chlorine resistance oxidoreductase RclA

chlor_oxi_RclA

3

IPR054848

54,848

Geranylgeranyl pyrophosphate synthase CRTE-like

GGPPSyn_CRT-like

Family

416

false

Geranylgeranyl diphosphate synthase CRTE (GGPPS) is an enzyme that catalyses the condensation of farnesyl diphosphate (FPP) and isopentenyl diphosphate (IPP) to yield geranylgeranyl diphosphate (GGPP) [ ]. This reaction is crucial for the biosynthesis of carotenoids and diterpenes. The enzyme belongs to the FPP/GGPP sy...

[]

0

[ "NCBIFAM" ]

[ "NF045685" ]

[ "GGPPSynCrtE" ]

[ 416 ]

1

[]

0

[ "6sxl", "7mxz", "7my0", "7my1", "7my6", "7my7" ]

6

[ "PUB00100305", "PUB00154610", "PUB00154611" ]

[ "24180436", "32523588", "10412909" ]

[ "Biosynthesis of ambiguine indole alkaloids in cyanobacterium Fischerella ambigua.", "Crystal Structure of Geranylgeranyl Pyrophosphate Synthase (CrtE) Involved in Cyanobacterial Terpenoid Biosynthesis.", "A thermophilic cyanobacterium Synechococcus elongatus has three different Class I prenyltransferase genes....

[ 2014, 2020, 1999 ]

3

[ "IPR053378" ]

[]

1

0

1

[ "Cyanobacteriota", "Eukaryota" ]

[ 364, 52 ]

2

[]

0

true

Family

Geranylgeranyl pyrophosphate synthase CRTE-like

GGPPSyn_CRT-like

5

IPR054849

54,849

UPF0336

UPF0336_fam

Family

659

true

This entry represents a family of proteins known as UPF0336. Members of this family are found in various Mycobacterium species, including Mycobacterium bovis, Mycobacterium leprae, Mycobacterium tuberculosis, and Mycolicibacterium paratuberculosis. The exact function of UPF0336 family proteins is currently unknown, but...

[]

0

[ "NCBIFAM" ]

[ "NF040624" ]

[ "UPF0336_fam" ]

[ 659 ]

1

[]

0

[ "4rlj", "4rlt", "4rlu", "4rlw", "4rv2", "7svt", "8y21" ]

7

[ "PUB00104910", "PUB00105858" ]

[ "17804795", "26104214" ]

[ "The missing piece of the type II fatty acid synthase system from Mycobacterium tuberculosis.", "The Molecular Genetics of Mycolic Acid Biosynthesis." ]

[ 2007, 2014 ]

2

[]

0

null

[ "Mycobacteriales", "freshwater metagenome" ]

[ 658, 1 ]

2

[]

0

true

Family

UPF0336

UPF0336_fam

5

IPR054850

54,850

Xylan 1,4-beta-xylosidase

Xylosidase_Xyl3A

Family

577

true

false

Xylan 1,4-beta-xylosidase (Xyl3A) from Xylanibacter ruminicola is a member of the glycosyl hydrolase 3 family. This enzyme is involved in the degradation of plant cell wall polysaccharides. It exhibits beta-xylosidase activity by hydrolyzing glycosidic linkages of beta-1,4-xylo-oligosaccharides of various lengths (X2 t...

[]

0

[ "NCBIFAM" ]

[ "NF041776" ]

[ "Xylosidase_Xyl3A" ]

[ 577 ]

1

[]

0

[]

0

[ "PUB00097679" ]

[ "19304844" ]

[ "Biochemical analysis of a beta-D-xylosidase and a bifunctional xylanase-ferulic acid esterase from a xylanolytic gene cluster in Prevotella ruminicola 23." ]

[ 2009 ]

1

[]

0

null

[ "Bacteroidota/Chlorobiota group", "metagenomes" ]

[ 574, 3 ]

2

[]

0

true

Family

Xylan 1,4-beta-xylosidase

Xylosidase_Xyl3A

7

IPR054851

54,851

Prenyl lipid carboxyl methyltransferase

Isoprenylcys_mtase

Family

439

true

false

This entry represents protein-S-isoprenylcysteine O-methyltransferase, an enzyme that catalyzes the methylation of isoprenylated cysteine residues in proteins. The enzyme exhibits activity towards prenyl lipids, including N-acetyl-S-farnesyl-L-cysteine (AFC) and S-farnesylthioacetic acid (FTA), an analog of AFC. It bel...

[]

0

[ "NCBIFAM" ]

[ "NF040696" ]

[ "Isoprenylcys_mtase" ]

[ 439 ]

1

[]

0

[ "4a2n" ]

1

[ "PUB00065859" ]

[ "22195972" ]

[ "Mechanism of isoprenylcysteine carboxyl methylation from the crystal structure of the integral membrane methyltransferase ICMT." ]

[ 2011 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "Methanomicrobia", "marine sediment metagenome" ]

[ 422, 7, 9, 1 ]

4

[]

0

true

Family

Prenyl lipid carboxyl methyltransferase

Isoprenylcys_mtase

2

IPR054852

54,852

Arginine ABC transporter substrate-binding protein ArtI

ArtI_ABC_transporter

Family

699

true

false

This entry represents the putative ABC transporter arginine-binding protein ArtI from Escherichia coli (strain K12). ArtI is part of the ABC transporter complex ArtPIQMJ, which is involved in the transport of arginine. Proteins in this family belong to the bacterial solute-binding protein 3 family.

[]

0

[ "NCBIFAM" ]

[ "NF041764" ]

[ "ArtI_ABC_transporter" ]

[ 699 ]

1

[]

0

[]

0

[ "PUB00152883" ]

[ "30698741" ]

[ "The y-ome defines the 35% of Escherichia coli genes that lack experimental evidence of function." ]

[ 2019 ]

1

[]

0

null

[ "Gammaproteobacteria" ]

[ 699 ]

1

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Arginine ABC transporter substrate-binding protein ArtI

ArtI_ABC_transporter

1

IPR054853

54,853

Lipid II isoglutaminyl synthase subunit MurT

isoglutsynth_MurT

Family

597

true

false

The lipid II isoglutaminyl synthase complex catalyzes the formation of alpha-D-isoglutamine in the cell wall lipid II stem peptide. The MurT subunit catalyzes the ATP-dependent amidation of the D-glutamate residue of lipid II, converting it to an isoglutamine residue. This function is essential for the proper formation...

[]

0

[ "NCBIFAM" ]

[ "NF045635" ]

[ "isoglutsynth_MurT" ]

[ 597 ]

1

[]

0

[ "6fqb" ]

1

[ "PUB00154652", "PUB00154653" ]

[ "30093673", "24044435" ]

[ "Structure of the essential peptidoglycan amidotransferase MurT/GatD complex from Streptococcus pneumoniae.", "In vitro reconstitution of peptidoglycan assembly from the Gram-positive pathogen Streptococcus pneumoniae." ]

[ 2018, 2013 ]

2

[]

0

null

[ "Bacteria" ]

[ 597 ]

1

[]

0

true

Family

Lipid II isoglutaminyl synthase subunit MurT

isoglutsynth_MurT

1

IPR054854

54,854

3-hydroxy-D-aspartate aldolase BhcC

HdxyAspAldBhcC

Family

487

true

false

3-hydroxy-D-aspartate aldolase (BhcC) is an enzyme that catalyzes the condensation of glyoxylate and glycine into (2R,3S)-beta-hydroxyaspartate ((3S)-3-hydroxy-D-aspartate). This enzyme plays a crucial role in the glyoxylate assimilation pathway known as the beta-hydroxyaspartate cycle (BHAC). In Paracoccus denitrifica...

[]

0

[ "NCBIFAM" ]

[ "NF045642" ]

[ "HdxyAspAldBhcC" ]

[ 487 ]

1

[]

0

[ "6qkb" ]

1

[ "PUB00154623", "PUB00154624" ]

[ "31723261", "12835921" ]

[ "Marine Proteobacteria metabolize glycolate via the β-hydroxyaspartate cycle.", "A novel enzyme, D-3-hydroxyaspartate aldolase from Paracoccus denitrificans IFO 13301: purification, characterization, and gene cloning." ]

[ 2019, 2003 ]

2

[]

0

null

[ "Bacteria", "ecological metagenomes" ]

[ 482, 5 ]

2

[]

0

true

Family

3-hydroxy-D-aspartate aldolase BhcC

HdxyAspAldBhcC

5

IPR054855

54,855

Cis-3-hydroxy-L-proline dehydratase, mandelate racemase/muconate lactonizing enzyme family

HProlDhtase

Family

184

true

false

Cis-3-hydroxy-L-proline dehydratase is an enzyme that catalyzes the dehydration of cis-3-hydroxy-L-proline (c3LHyp) to Delta(1)-pyrroline-2-carboxylate (Pyr2C). This enzyme is likely involved in a degradation pathway that converts c3LHyp to L-proline, allowing certain bacteria such as Roseibium aggregatum and Ancylobac...

[]

0

[ "NCBIFAM" ]

[ "NF043002" ]

[ "HProlDhtase" ]

[ 184 ]

1

[]

0

[ "4mgg" ]

1

[ "PUB00083792" ]

[ "25608448" ]

[ "A unique cis-3-hydroxy-l-proline dehydratase in the enolase superfamily." ]

[ 2015 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "Halobacteriales", "ecological metagenomes" ]

[ 161, 9, 3, 11 ]

4

[]

0

true

Family

Cis-3-hydroxy-L-proline dehydratase, mandelate racemase/muconate lactonizing enzyme family

HProlDhtase

4

IPR054857

54,857

Cyclic nucleotide-degrading phosphodiesterase

cyc_nuc_deg_phdiest

Family

590

true

false

This entry represents a family of cyclic nucleotide-degrading phosphodiesterases. These enzymes are involved in the hydrolysis of cyclic nucleotides, such as cAMP and cGMP, into their corresponding nucleoside monophosphates. Members of this family include uncharacterized proteins from various Mycobacterium species, suc...

[]

0

[ "NCBIFAM" ]

[ "NF041851" ]

[ "cyc_nuc_deg_phdiest" ]

[ 590 ]

1

[]

0

[]

0

[ "PUB00152928" ]

[ "36760076" ]

[ "Mycobacterial phosphodiesterase Rv0805 is a virulence determinant and its cyclic nucleotide hydrolytic activity is required for propionate detoxification." ]

[ 2023 ]

1

[]

0

null

[ "Mycobacteriales", "freshwater metagenome" ]

[ 589, 1 ]

2

[]

0

true

Family

Cyclic nucleotide-degrading phosphodiesterase

cyc_nuc_deg_phdiest

3

IPR054858

54,858

Peptidoglycan-N-acetylglucosamine deacetylase BC_1974

PgAcgDac_BC_1974

Family

466

false

Peptidoglycan-N-acetylglucosamine deacetylase (BC_1974) from Bacillus cereus (strain ATCC 14579) catalyses the deacetylation of N-acetylglucosamine (GlcNAc) residues in peptidoglycan. This enzyme belongs to the polysaccharide deacetylase family and is involved in modifying the peptidoglycan structure, which is crucial ...

[]

0

[ "NCBIFAM" ]

[ "NF045822" ]

[ "PgAcgDacpgdA2_Bac" ]

[ 466 ]

1

[]

0

[ "5n1j", "5n1p", "5nc6", "5nc9", "5ncd", "5nek", "5nel" ]

7

[ "PUB00154682" ]

[ "29983281" ]

[ "Polysaccharide deacetylases serve as new targets for the design of inhibitors against Bacillus anthracis and Bacillus cereus." ]

[ 2018 ]

1

[ "IPR050248" ]

[]

1

0

1

[ "Bacillus" ]

[ 466 ]

1

[]

0

true

Family

Peptidoglycan-N-acetylglucosamine deacetylase BC_1974

PgAcgDac_BC_1974

7

IPR054859

54,859

Lipid II isoglutaminyl synthase subunit GatD

isoglutsynth_GatD

Family

561

true

false

The lipid II isoglutaminyl synthase complex catalyzes the formation of alpha-D-isoglutamine in the cell wall lipid II stem peptide. The GatD subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia. The resulting ammonia molecule is channeled to the active site of MurT. This function is critical for the b...

[]

0

[ "NCBIFAM" ]

[ "NF045636" ]

[ "isoglutsynth_GatD" ]

[ 561 ]

1

[]

0

[ "6fqb", "9sq9", "9sqj" ]

3

[ "PUB00154652" ]

[ "30093673" ]

[ "Structure of the essential peptidoglycan amidotransferase MurT/GatD complex from Streptococcus pneumoniae." ]

[ 2018 ]

1

[]

0

null

[ "Bacteria" ]

[ 561 ]

1

[]

0

true

Family

Lipid II isoglutaminyl synthase subunit GatD

isoglutsynth_GatD

7

IPR054860

54,860

Iminosuccinate reductase BhcD

BhcD-like

Family

463

true

Iminosuccinate reductase BhcD is an enzyme that catalyzes the NADH-dependent reduction of iminosuccinate to L-aspartate [ ]. This enzyme is essential for the growth of Paracoccus denitrificans in the presence of glycolate and glyoxylate, as it functions in glyoxylate assimilation via the beta-hydroxyaspartate cycle (BH...

[]

0

[ "NCBIFAM" ]

[ "NF045643" ]

[ "ImmsucRedBhcD" ]

[ 463 ]

1

[]

0

[ "6rqa" ]

1

[ "PUB00154623" ]

[ "31723261" ]

[ "Marine Proteobacteria metabolize glycolate via the β-hydroxyaspartate cycle." ]

[ 2019 ]

1

[]

0

null

[ "Effrenium voratum", "Pseudomonadota", "ecological metagenomes" ]

[ 1, 457, 5 ]

3

[]

0

true

Family

Iminosuccinate reductase BhcD

BhcD-like

2

IPR054861

54,861

Endo-beta-N-acetylglucosaminidase H

Endoglyc_H

Family

507

true

false

This entry represents endo-beta-N-acetylglucosaminidase H, a member of the glycosyl hydrolase 18 family. These enzymes cleave asparagine-linked oligomannose and hybrid, but not complex, oligosaccharides from glycoproteins. The proteins matched by this entry include endo-beta-N-acetylglucosaminidase H from Streptomyces ...

[]

0

[ "NCBIFAM" ]

[ "NF045482" ]

[ "Endoglyc_H" ]

[ 507 ]

1

[]

0

[ "1c3f", "1c8x", "1c8y", "1c90", "1c91", "1c92", "1c93", "1edt", "6ve1" ]

9

[ "PUB00021308", "PUB00024509" ]

[ "10595536", "7663942" ]

[ "Mutations of endo-beta-N-acetylglucosaminidase H active site residueAs sp130 anG glu132: activities and conformations.", "Crystal structure of endo-beta-N-acetylglucosaminidase H at 1.9 A resolution: active-site geometry and substrate recognition." ]

[ 1999, 1995 ]

2

[]

0

null

[ "Bacteria", "Opisthokonta" ]

[ 502, 5 ]

2

[]

0

true

Family

Endo-beta-N-acetylglucosaminidase H

Endoglyc_H

6

IPR054862

54,862

DNA protection during starvation protein

DNA_prot_starvation

Family

459

true

false

The DNA protection during starvation protein (Dps) is a member of the Dps family, which plays a crucial role in protecting DNA from oxidative damage. This protection is achieved by sequestering intracellular Fe(2+) ions and storing them in the form of Fe(3+) oxyhydroxide mineral. The process involves the oxidation of t...

[]

0

[ "NCBIFAM" ]

[ "NF041388" ]

[ "DNA_prot_starvation" ]

[ 459 ]

1

[]

0

[ "1moj", "1tjo", "1tk6", "1tko", "1tkp" ]

5

[ "PUB00016788", "PUB00080655" ]

[ "15365182", "12147354" ]

[ "Iron-oxo clusters biomineralizing on protein surfaces: structural analysis of Halobacterium salinarum DpsA in its low- and high-iron states.", "The DpsA-homologue of the archaeon Halobacterium salinarum is a ferritin." ]

[ 2004, 2002 ]

2

[]

0

null

[ "Bacteria", "Halobacteria" ]

[ 11, 448 ]

2

[]

0

true

Family

DNA protection during starvation protein

DNA_prot_starvation

7

IPR054863

54,863

L-aspartate--glyoxylate aminotransferase

AspGlyoxATase

Family

423

true

false

L-aspartate--glyoxylate aminotransferase (BhcA) from Paracoccus denitrificans (strain Pd 1222) is an enzyme that catalyzes the transamination of glyoxylate into glycine using L-aspartate as the preferred amino group donor. This enzyme is essential for the growth of P. denitrificans in the presence of glycolate and glyo...

[]

0

[ "NCBIFAM" ]

[ "NF045640" ]

[ "AspGlyoxATase" ]

[ 423 ]

1

[]

0

[]

0

[ "PUB00154623" ]

[ "31723261" ]

[ "Marine Proteobacteria metabolize glycolate via the β-hydroxyaspartate cycle." ]

[ 2019 ]

1

[]

0

null

[ "Effrenium voratum", "Pseudomonadota", "ecological metagenomes" ]

[ 1, 420, 2 ]

3

[]

0

true

Family

L-aspartate--glyoxylate aminotransferase

AspGlyoxATase

2

IPR054864

54,864

Oligopeptide ABC transporter permease OppC

OppC_permease

Family

461

true

false

This entry represents the oligopeptide ABC transporter permease OppC, also known as AmiD, found in Streptococcus pneumoniae. These proteins are part of the binding-protein-dependent transport system for oligopeptides and are likely responsible for the translocation of substrates across the membrane. They belong to the ...

[]

0

[ "NCBIFAM" ]

[ "NF043080" ]

[ "OppC_permease" ]

[ 461 ]

1

[]

0

[]

0

[ "PUB00153514", "PUB00153515" ]

[ "31308405", "20488990" ]

[ "Environmental conditions shape the nature of a minimal bacterial genome.", "Creation of a bacterial cell controlled by a chemically synthesized genome." ]

[ 2019, 2010 ]

2

[]

0

null

[ "Bacteria" ]

[ 461 ]

1

[]

0

true

Family

Oligopeptide ABC transporter permease OppC

OppC_permease

3

IPR054865

54,865

Superoxide dismutase [Mn], archaeal

Superox_dis_Halo

Family

413

true

false

This entry represents superoxide dismutase [Mn] enzymes found in various archaeal species, including Halobacterium salinarum, Haloferax volcanii, and Haloarcula marismortui. These enzymes belong to the iron/manganese superoxide dismutase family and are responsible for the destruction of superoxide anion radicals, which...

[]

0

[ "NCBIFAM" ]

[ "NF041312" ]

[ "Superox_dis_Halo" ]

[ 413 ]

1

[ "EC", "METACYC" ]

[ "1.15.1.1", "PWY-6854" ]

[ "EC:1.15.1.1", "METACYC:PWY-6854" ]

2

[]

0

[ "PUB00106319", "PUB00106320", "PUB00106321" ]

[ "3104309", "3341765", "8449865" ]

[ "Superoxide dismutase from the extremely halophilic archaebacterium Halobacterium cutirubrum.", "Purification of a manganese-containing superoxide dismutase from Halobacterium halobium.", "Characterization of paralogous and orthologous members of the superoxide dismutase gene family from genera of the halophili...

[ 1987, 1988, 1993 ]

3

[]

0

null

[ "Archaea" ]

[ 413 ]

1

[]

0

true

Family

Superoxide dismutase [Mn], archaeal

Superox_dis_Halo

7

IPR054866

54,866

15-cis-phytoene synthase

PhytoSynCyanob

Family

287

true

false

This entry represents 15-cis-phytoene synthase, also known as CrtB, which is involved in the biosynthesis of carotenoids. The enzyme catalyzes the condensation of two molecules of geranylgeranyl diphosphate (GGPP) to form prephytoene diphosphate (PPPP), followed by the rearrangement of the cyclopropylcarbinyl intermedi...

[]

0

[ "NCBIFAM" ]

[ "NF045686" ]

[ "PhytoSynCyanob" ]

[ 287 ]

1

[ "EC" ]

[ "2.5.1.32" ]

[ "EC:2.5.1.32" ]

1

[]

0

[ "PUB00154612", "PUB00154613" ]

[ "1537409", "8018713" ]

[ "Molecular cloning and expression in Escherichia coli of a cyanobacterial gene coding for phytoene synthase, a carotenoid biosynthesis enzyme.", "Cloning and expression in Escherichia coli of the gene coding for phytoene synthase from the cyanobacterium Synechocystis sp. PCC6803." ]

[ 1992, 1994 ]

2

[]

0

null

[ "Cyanobacteriota" ]

[ 287 ]

1

[]

0

true

Family

15-cis-phytoene synthase

PhytoSynCyanob

7

IPR054867

54,867

Glutamate dehydrogenase B

GluDhGdhB

Family

452

true

false

This entry represents glutamate dehydrogenases from Halobacterium salinarum, including Glutamate dehydrogenase B (GdhB) and NAD-specific glutamate dehydrogenase A (GdhX). These enzymes belong to the Glu/Leu/Phe/Val dehydrogenases family. Glutamate dehydrogenases are involved in the reversible oxidative deamination of g...

[]

0

[ "NCBIFAM" ]

[ "NF041398" ]

[ "GluDhGdhB" ]

[ 452 ]

1

[]

0

[]

0

[ "PUB00106375" ]

[ "15780999" ]

[ "The discovery of four distinct glutamate dehydrogenase genes in a strain of Halobacterium salinarum." ]

[ 2005 ]

1

[]

0

null

[ "Halobacteria" ]

[ 452 ]

1

[]

0

true

Family

Glutamate dehydrogenase B

GluDhGdhB

6

IPR054868

54,868

Archaetidylinositol phosphate synthase, archaeal

archin_ph_syn

Family

195

true

false

Archaetidylinositol phosphate synthase (AIPS) is an enzyme that catalyzes the formation of archaetidylinositol phosphate (AIP) from CDP-archaeol (CDP-ArOH or CDP-2,3-bis-(O-phytanyl)-sn-glycerol) and 1L-myo-inositol 1-phosphate (IP or 1D-myo-inositol 3-phosphate). AIP is a precursor of archaetidyl-myo-inositol (AI), an...

[]

0

[ "NCBIFAM" ]

[ "NF040950" ]

[ "archin_ph_syn" ]

[ 195 ]

1

[ "EC", "METACYC", "METACYC" ]

[ "2.7.8.39", "PWY-6350", "PWY-8365" ]

[ "EC:2.7.8.39", "METACYC:PWY-6350", "METACYC:PWY-8365" ]

3

[]

0

[ "PUB00106084" ]

[ "24269814" ]

[ "Ubiquitous distribution of phosphatidylinositol phosphate synthase and archaetidylinositol phosphate synthase in Bacteria and Archaea, which contain inositol phospholipid." ]

[ 2014 ]

1

[]

0

null

[ "Archaea", "Thermosulfidibacter takaii", "bioreactor metagenome" ]

[ 193, 1, 1 ]

3

[]

0

true

Family

Archaetidylinositol phosphate synthase, archaeal

archin_ph_syn

3

IPR054869

54,869

Aldehyde dehydrogenase, thermostable

AlphKGSA_gudD

Family

493

true

false

This entry represents alpha-ketoglutaric semialdehyde dehydrogenase (GucD) and thermostable aldehyde dehydrogenase from Bacillus subtilis (strain 168) and Geobacillus stearothermophilus, respectively. These enzymes belong to the aldehyde dehydrogenase family and catalyze the NAD(P)(+)-dependent oxidation of alpha-ketog...

[]

0

[ "NCBIFAM" ]

[ "NF042993" ]

[ "AlphKGSA_gudD" ]

[ 493 ]

1

[]

0

[]

0

[ "PUB00095200" ]

[ "17202142" ]

[ "alpha-ketoglutaric semialdehyde dehydrogenase isozymes involved in metabolic pathways of D-glucarate, D-galactarate, and hydroxy-L-proline. Molecular and metabolic convergent evolution." ]

[ 2007 ]

1

[]

0

null

[ "Bacillales" ]

[ 493 ]

1

[]

0

true

Family

Aldehyde dehydrogenase, thermostable

AlphKGSA_gudD

7

IPR054870

54,870

N-acyl homoserine lactonase AiiA

AiiA

Family

387

true

This entry represents N-acyl homoserine lactonase AiiA enzymes from bacilalles. which belong to the metallo-beta-lactamase superfamily. AiiA catalyses the hydrolysis of N-acyl homoserine lactones (AHLs) [ ], which are signalling molecules used in quorum sensing by various bacteria. The enzyme shows activity towards bot...

[]

0

[ "NCBIFAM" ]

[ "NF045699" ]

[ "AHLLactAiiA" ]

[ 387 ]

1

[ "EC" ]

[ "3.1.1.81" ]

[ "EC:3.1.1.81" ]

1

[ "2a7m", "2br6", "2btn", "3dha", "3dhb", "3dhc", "4j5f", "4j5h", "5eh9", "5eht", "7l5f" ]

11

[ "PUB00154679", "PUB00154680", "PUB00163187", "PUB00163188", "PUB00163189" ]

[ "10716724", "11459062", "16972128", "27444875", "34095651" ]

[ "AiiA, an enzyme that inactivates the acylhomoserine lactone quorum-sensing signal and attenuates the virulence of Erwinia carotovora.", "Quenching quorum-sensing-dependent bacterial infection by an N-acyl homoserine lactonase.", "Identification of the critical role of Tyr-194 in the catalytic activity of a nov...

[ 2000, 2001, 2006, 2016, 2021 ]

5

[ "IPR051013" ]

[]

1

0

1

[ "Bacteria" ]

[ 387 ]

1

[]

0

true

Family

N-acyl homoserine lactonase AiiA

AiiA

2

IPR054871

54,871

Bifunctional 2-dehydro-3-deoxygluconokinase/2-dehydro-3-deoxygalactonokinase

KDG_KDGal_kin_Halo

Family

352

true

false

This entry represents bifunctional enzymes that exhibit both 2-dehydro-3-deoxygluconokinase and 2-dehydro-3-deoxygalactonokinase activities. These enzymes are involved in the degradation of glucose via the semi-phosphorylative Entner-Doudoroff pathway and galactose catabolism. They catalyze the phosphorylation of 2-ket...

[]

0

[ "NCBIFAM" ]

[ "NF041332" ]

[ "KDG_KDGal_kin_Halo" ]

[ 352 ]

1

[]

0

[]

0

[ "PUB00106336" ]

[ "25287957" ]

[ "Identification and characterization of 2-keto-3-deoxygluconate kinase and 2-keto-3-deoxygalactonate kinase in the haloarchaeon Haloferax volcanii." ]

[ 2014 ]

1

[]

0

null

[ "Halobacteriales" ]

[ 352 ]

1

[]

0

true

Family

Bifunctional 2-dehydro-3-deoxygluconokinase/2-dehydro-3-deoxygalactonokinase

KDG_KDGal_kin_Halo

2

IPR054873

54,873

Peroxynitrite isomerase

PeroxynitIsom

Family

383

true

false

This entry represents peroxynitrite isomerases, which belong to the nitrobindin family. These proteins form a 10-stranded antiparallel beta-barrel structure capable of accommodating a hydrophobic ligand in its interior. The fold hosts a heme group located in a wide surface cleft. The primary function of these proteins ...

[]

0

[ "NCBIFAM" ]

[ "NF045819" ]

[ "PeroxynitIsom" ]

[ 383 ]

1

[]

0

[ "2fr2", "6r3w", "6r3y" ]

3

[ "PUB00099650" ]

[ "32295384" ]

[ "Mycobacterial and Human Nitrobindins: Structure and Function." ]

[ 2020 ]

1

[]

0

null

[ "Actinomycetota", "Populus alba x Populus x berolinensis", "freshwater metagenome" ]

[ 381, 1, 1 ]

3

[]

0

true

Family

Peroxynitrite isomerase

PeroxynitIsom

6

IPR054875

54,875

Indole-3-glycerol phosphate synthase, archaeal

Indglycph_syn_Halo_TrpC

Family

330

true

false

Indole-3-glycerol phosphate synthase (IGPS) is an enzyme that catalyses the conversion of 1-(2-carboxyphenylamino)-1-deoxyribulose-5-phosphate to indole-3-glycerol phosphate, a key step in the biosynthesis of tryptophan. This enzyme is part of the TrpC family and is found in various archaeal species, including Halofera...

[]

0

[ "NCBIFAM" ]

[ "NF041303" ]

[ "Indglycph_syn_Halo_TrpC" ]

[ 330 ]

1

[ "EC" ]

[ "4.1.1.48" ]

[ "EC:4.1.1.48" ]

1

[]

0

[ "PUB00106307" ]

[ "2118654" ]

[ "Genes for tryptophan biosynthesis in the archaebacterium Haloferax volcanii." ]

[ 1990 ]

1

[]

0

null

[ "Halobacteriales" ]

[ 330 ]

1

[]

0

true

Family

Indole-3-glycerol phosphate synthase, archaeal

Indglycph_syn_Halo_TrpC

2

IPR054876

54,876

RIO-type serine/threonine-protein kinase Rio1

RIO1_kinase

Family

324

true

false

RIO-type serine/threonine-protein kinase Rio1 is a serine/threonine-protein kinase that is capable of autophosphorylation and can phosphorylate proteasome subunit alpha 1 (PsmA1) in vitro. Despite having a protein kinase domain, it is proposed to function predominantly as an ATPase. This protein belongs to the protein ...

[]

0

[ "NCBIFAM" ]

[ "NF041310" ]

[ "RIO1_kinase" ]

[ 324 ]

1

[]

0

[]

0

[ "PUB00106316" ]

[ "20671954" ]

[ "Phosphorylation and methylation of proteasomal proteins of the haloarcheon Haloferax volcanii." ]

[ 2010 ]

1

[]

0

null

[ "Halobacteriales" ]

[ 324 ]

1

[]

0

true

Family

RIO-type serine/threonine-protein kinase Rio1

RIO1_kinase

4

IPR054877

54,877

Phthiotriol/phenolphthiotriol dimycocerosates methyltransferase

PthPhpthDimycoMt

Family

343

true

false

This entry represents phthiotriol/phenolphthiotriol dimycocerosates methyltransferases, which are enzymes that catalyze the methylation of the lipid moiety of intermediate compounds such as phthiotriol and glycosylated phenolphthiotriol dimycocerosates. This methylation process results in the formation of phthiocerol d...

[]

0

[ "NCBIFAM" ]

[ "NF045823" ]

[ "PthPhpthDimycoMt" ]

[ 343 ]

1

[ "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC"...

[ "2.1.1.-", "PWY-1061", "PWY-2083", "PWY-3542", "PWY-4021", "PWY-4161", "PWY-4202", "PWY-5059", "PWY-5105", "PWY-5301", "PWY-5305", "PWY-5479", "PWY-5665", "PWY-5729", "PWY-5748", "PWY-5765", "PWY-5773", "PWY-5846", "PWY-5883", "PWY-5975", "PWY-5987", "PWY-601", "PWY-6045"...

[ "EC:2.1.1.-", "METACYC:PWY-1061", "METACYC:PWY-2083", "METACYC:PWY-3542", "METACYC:PWY-4021", "METACYC:PWY-4161", "METACYC:PWY-4202", "METACYC:PWY-5059", "METACYC:PWY-5105", "METACYC:PWY-5301", "METACYC:PWY-5305", "METACYC:PWY-5479", "METACYC:PWY-5665", "METACYC:PWY-5729", "METACYC:PWY-5...

146

[]

0

[ "PUB00053670" ]

[ "15292265" ]

[ "Molecular dissection of the role of two methyltransferases in the biosynthesis of phenolglycolipids and phthiocerol dimycoserosate in the Mycobacterium tuberculosis complex." ]

[ 2004 ]

1

[]

0

null

[ "Bacteria" ]

[ 343 ]

1

[]

0

true

Family

Phthiotriol/phenolphthiotriol dimycocerosates methyltransferase

PthPhpthDimycoMt

2

IPR054878

54,878

Endonuclease VIII Nei2

Endonuc_Nei2

Family

342

true

false

This entry represents endonuclease VIII Nei2, a member of the FPG family. Endonuclease VIII Nei2 is involved in the base excision repair of DNA damaged by oxidation or mutagenic agents. It functions as a DNA glycosylase that recognizes and removes damaged bases, and has AP (apurinic/apyrimidinic) lyase activity. The en...

[]

0

[ "NCBIFAM" ]

[ "NF040775" ]

[ "Endonuc_Nei2" ]

[ 342 ]

1

[ "EC", "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC" ]

[ "3.2.2.-", "4.2.99.18", "PWY-2681", "PWY-5316", "PWY-5381", "PWY-7342", "PWY-7564", "PWY-8106" ]

[ "EC:3.2.2.-", "EC:4.2.99.18", "METACYC:PWY-2681", "METACYC:PWY-5316", "METACYC:PWY-5381", "METACYC:PWY-7342", "METACYC:PWY-7564", "METACYC:PWY-8106" ]

8

[ "8tjg" ]

1

[ "PUB00105955", "PUB00105956" ]

[ "28955788", "34820919" ]

[ "Biochemical characterization and novel inhibitor identification of Mycobacterium tuberculosis Endonuclease VIII 2 (Rv3297).", "Mycobacterium tuberculosis Endonuclease VIII 2 (Nei2) forms a prereplicative BER complex with DnaN: Identification, characterization, and disruption of complex formation." ]

[ 2017, 2022 ]

2

[]

0

null

[ "Mycobacteriales" ]

[ 342 ]

1

[]

0

true

Family

Endonuclease VIII Nei2

Endonuc_Nei2

6

IPR054879

54,879

Rad50/Mre11 complex component

Mre11_Halo

Family

319

true

false

The DNA double-strand break repair protein Mre11 is a crucial component of the Rad50/Mre11 complex, which plays a significant role in the early steps of DNA double-strand break (DSB) repair. Mre11 binds to DSB ends and exhibits both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity. I...

[]

0

[ "NCBIFAM" ]

[ "NF041030" ]

[ "Mre11_Halo" ]

[ 319 ]

1

[]

0

[]

0

[ "PUB00076983", "PUB00153517" ]

[ "19593371", "18502851" ]

[ "Mre11-Rad50 promotes rapid repair of DNA damage in the polyploid archaeon Haloferax volcanii by restraining homologous recombination.", "Rad50 is not essential for the Mre11-dependent repair of DNA double-strand breaks in Halobacterium sp. strain NRC-1." ]

[ 2009, 2008 ]

2

[]

0

null

[ "Halobacteriales" ]

[ 319 ]

1

[]

0

true

Family

Rad50/Mre11 complex component

Mre11_Halo

9

IPR054880

54,880

Menaquinone reductase

MkRedMenJ

Family

345

true

false

Menaquinone reductase, also known as MenJ, is an enzyme that catalyzes the reduction of a single double bond in the isoprenoid tail of menaquinone (MK-9) in mycobacteria, likely the beta-isoprene unit. This reaction forms the predominant form of menaquinone found in mycobacteria, MK-9(II-H2). The enzyme belongs to the ...

[]

0

[ "NCBIFAM" ]

[ "NF045655" ]

[ "MkRedMenJ" ]

[ 345 ]

1

[ "EC", "METACYC" ]

[ "1.3.99.38", "PWY-7993" ]

[ "EC:1.3.99.38", "METACYC:PWY-7993" ]

2

[]

0

[ "PUB00154698" ]

[ "26436137" ]

[ "Partial Saturation of Menaquinone in Mycobacterium tuberculosis: Function and Essentiality of a Novel Reductase, MenJ." ]

[ 2015 ]

1

[]

0

null

[ "Mycobacteriaceae" ]

[ 345 ]

1

[]

0

true

Family

Menaquinone reductase

MkRedMenJ

3

IPR054881

54,881

3-phenylpropionate/cinnamic acid dioxygenase subunit beta

3PPDioc_HcaF

Family

313

true

false

This entry represents the beta subunit of the multicomponent 3-phenylpropionate/cinnamic acid dioxygenase enzyme complex. This enzyme complex is responsible for the conversion of 3-phenylpropionic acid (PP) and cinnamic acid (CI) into their respective dihydrodiol forms, 3-phenylpropionate-dihydrodiol (PP-dihydrodiol) a...

[]

0

[ "NCBIFAM" ]

[ "NF042947" ]

[ "3PPDioc_HcaF" ]

[ 313 ]

1

[ "EC", "METACYC" ]

[ "1.14.12.19", "PWY-6690" ]

[ "EC:1.14.12.19", "METACYC:PWY-6690" ]

2

[ "8k0a" ]

1

[ "PUB00054929" ]

[ "9603882" ]

[ "Characterization of the hca cluster encoding the dioxygenolytic pathway for initial catabolism of 3-phenylpropionic acid in Escherichia coli K-12." ]

[ 1998 ]

1

[]

0

null

[ "Pseudomonadota" ]

[ 313 ]

1

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

3-phenylpropionate/cinnamic acid dioxygenase subunit beta

3PPDioc_HcaF

4

IPR054882

54,882

Outer membrane protein Omp38

Omp38

Family

251

true

false

Outer membrane protein Omp38 is a member of the outer membrane OOP (TC 1.B.6) superfamily. This protein functions as a porin, facilitating the transport of molecules across the outer membrane. In Acinetobacter baumannii, Omp38 has been shown to induce apoptosis in human cell lines through caspase-dependent and AIF-depe...

[]

0

[ "NCBIFAM" ]

[ "NF045788" ]

[ "Omp38" ]

[ 251 ]

1

[]

0

[]

0

[ "PUB00065666", "PUB00154795", "PUB00154796" ]

[ "21965596", "9928952", "16008580" ]

[ "Mechanism of anchoring of OmpA protein to the cell wall peptidoglycan of the gram-negative bacterial outer membrane.", "Purification and characterization of a major 40 kDa outer membrane protein of Acinetobacter baumannii.", "Outer membrane protein 38 of Acinetobacter baumannii localizes to the mitochondria an...

[ 2012, 1999, 2005 ]

3

[]

0

null

[ "Moraxellaceae", "Oppiella nova" ]

[ 250, 1 ]

2

[]

0

true

Family

Outer membrane protein Omp38

Omp38

8

IPR054883

54,883

3-phenylpropionate/cinnamic acid dioxygenase subunit alpha

3PPDioc_HcaE

Family

298

true

false

This entry represents the alpha subunit of the 3-phenylpropionate/cinnamic acid dioxygenase enzyme complex. This multicomponent dioxygenase converts 3-phenylpropionic acid (PP) and cinnamic acid (CI) into their respective dihydrodiol forms, 3-phenylpropionate-dihydrodiol (PP-dihydrodiol) and cinnamic acid-dihydrodiol (...

[]

0

[ "NCBIFAM" ]

[ "NF042946" ]

[ "3PPDioc_HcaE" ]

[ 298 ]

1

[ "EC", "METACYC" ]

[ "1.14.12.19", "PWY-6690" ]

[ "EC:1.14.12.19", "METACYC:PWY-6690" ]

2

[ "8k0a" ]

1

[ "PUB00054929" ]

[ "9603882" ]

[ "Characterization of the hca cluster encoding the dioxygenolytic pathway for initial catabolism of 3-phenylpropionic acid in Escherichia coli K-12." ]

[ 1998 ]

1

[]

0

null

[ "Pseudomonadota", "bioreactor metagenome" ]

[ 297, 1 ]

2

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

3-phenylpropionate/cinnamic acid dioxygenase subunit alpha

3PPDioc_HcaE

4

IPR054884

54,884

DGGGPL reductase

Dggglyphlred_Halo

Family

296

true

false

Digeranylgeranylglycerophospholipid reductase (DGGGPL reductase) is an enzyme involved in the biosynthesis of archaeal membrane lipids. It catalyzes the reduction of 2,3-digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols). This enzyme can fully redu...

[]

0

[ "NCBIFAM" ]

[ "NF041385" ]

[ "Dggglyphlred_Halo" ]

[ 296 ]

1

[]

0

[]

0

[ "PUB00089906" ]

[ "22469971" ]

[ "A predicted geranylgeranyl reductase reduces the ω-position isoprene of dolichol phosphate in the halophilic archaeon, Haloferax volcanii." ]

[ 2012 ]

1

[]

0

null

[ "Halobacteriales" ]

[ 296 ]

1

[]

0

true

Family

DGGGPL reductase

Dggglyphlred_Halo

5

IPR054885

54,885

(2E,6E)-farnesyl diphosphate synthase

FPP_synthase

Family

316

true

false

This entry represents (2E,6E)-farnesyl diphosphate synthase, an enzyme that catalyzes the sequential condensations of isopentenyl pyrophosphate (IPP) with dimethylallyl diphosphate (DMAPP) to yield geranyl diphosphate (GPP) and with GPP to yield (2E,6E)-farnesyl diphosphate (E,E-FPP). The enzyme contains two aspartate-...

[]

0

[ "NCBIFAM" ]

[ "NF042416" ]

[ "FPP_synthase" ]

[ 316 ]

1

[]

0

[ "8f8f", "8f8k", "8f8l" ]

3

[ "PUB00153500" ]

[ "32495977" ]

[ "Insight into Isoprenoid Biosynthesis by Functional Analysis of Isoprenyl Diphosphate Synthases from Mycobacterium vanbaalenii and Mycobacterium tuberculosis." ]

[ 2020 ]

1

[]

0

null

[ "Mycobacteriaceae" ]

[ 316 ]

1

[]

0

true

Family

(2E,6E)-farnesyl diphosphate synthase

FPP_synthase

3

IPR054886

54,886

UDP-glucose 6-dehydrogenase AglM

UDPGDh_AglM

Family

287

true

false

UDP-glucose 6-dehydrogenase AglM is an enzyme involved in the assembly of a N-linked pentasaccharide that decorates the S-layer glycoprotein and flagellins in Haloferax volcanii. It plays a crucial role in the biosynthesis of the hexuronic acids found at both positions 2 and 3 of the pentasaccharide. The activity of th...

[]

0

[ "NCBIFAM" ]

[ "NF041297" ]

[ "UDPGDh_AglM" ]

[ 287 ]

1

[]

0

[]

0

[ "PUB00106302", "PUB00106303" ]

[ "20487296", "22730124" ]

[ "N-glycosylation in Archaea: on the coordinated actions of Haloferax volcanii AglF and AglM.", "N-glycosylation of Haloferax volcanii flagellins requires known Agl proteins and is essential for biosynthesis of stable flagella." ]

[ 2010, 2012 ]

2

[]

0

null

[ "Halobacteriales" ]

[ 287 ]

1

[]

0

true

Family

UDP-glucose 6-dehydrogenase AglM

UDPGDh_AglM

5

IPR054887

54,887

Dolichyl-phosphate hexose transferase

DPhHxTase

Family

261

true

false

Dolichyl-phosphate hexose transferase is a glycosyltransferase that belongs to the glycosyltransferase 2 family. This enzyme is responsible for adding a monosaccharide to dolichol phosphate, thereby generating one of the three monosaccharide-modified dolichol phosphates. The specific subunit onto which additional sugar...

[]

0

[ "NCBIFAM" ]

[ "NF041391" ]

[ "DPhHxTase" ]

[ 261 ]

1

[]

0

[]

0

[ "PUB00060477" ]

[ "20802039" ]

[ "AglJ adds the first sugar of the N-linked pentasaccharide decorating the Haloferax volcanii S-layer glycoprotein." ]

[ 2010 ]

1

[]

0

null

[ "Halobacteria" ]

[ 261 ]

1

[]

0

true

Family

Dolichyl-phosphate hexose transferase

DPhHxTase

3

IPR054888

54,888

Olefin beta-lactone synthetase

OlefBLtnSyn

Family

309

true

false

Olefin beta-lactone synthetase is an enzyme involved in the biosynthesis of olefins. It catalyzes the conversion of beta-hydroxy acid substrates to beta-lactones in the presence of ATP. This enzyme can use various stereoisomers of 2-hexyl-3-hydroxydecanoic acid and 2-alkyl-3-hydroxyalkanoic acids as substrates. The enz...

[]

0

[ "NCBIFAM" ]

[ "NF045786" ]

[ "OlefBLtnSyn" ]

[ 309 ]

1

[]

0

[]

0

[ "PUB00154644", "PUB00154645", "PUB00154646" ]

[ "21266575", "20823539", "27238740" ]

[ "Purification and characterization of OleA from Xanthomonas campestris and demonstration of a non-decarboxylative Claisen condensation reaction.", "Cloning, purification, crystallization and preliminary X-ray diffraction of the OleC protein from Stenotrophomonas maltophilia involved in head-to-head hydrocarbon bi...

[ 2011, 2010, 2016 ]

3

[]

0

null

[ "Knufia peltigerae", "Pseudomonadati" ]

[ 1, 308 ]

2

[]

0

true

Family

Olefin beta-lactone synthetase

OlefBLtnSyn

9

IPR054889

54,889

N-acyl homoserine lactonase AttM

AttM

Family

269

true

This protein family includes N-acyl homoserine lactonase AttM from Agrobacterium tumefaciens and similar proteins mainly found in proteobacteria. N-acyl homoserine lactonase AttM is an enzyme that belongs to the metallo-beta-lactamase superfamily. This enzyme is involved in the hydrolysis of N-acyl homoserine lactones ...

[]

0

[ "NCBIFAM" ]

[ "NF045700" ]

[ "AHLLactAttM" ]

[ 269 ]

1

[ "EC" ]

[ "3.1.1.81" ]

[ "EC:3.1.1.81" ]

1

[ "9kho", "9khq" ]

2

[ "PUB00154627" ]

[ "11930013" ]

[ "Genetic control of quorum-sensing signal turnover in Agrobacterium tumefaciens." ]

[ 2002 ]

1

[ "IPR051013" ]

[]

1

0

1

[ "Bacteria", "Ricinus communis", "marine metagenome" ]

[ 260, 1, 8 ]

3

[]

0

true

Family

N-acyl homoserine lactonase AttM

AttM

7

IPR054890

54,890

ATP-dependent DNA ligase LigA

LigA_Halo

Family

263

true

false

This entry represents ATP-dependent DNA ligases, specifically the LigA type found in various halophilic archaea. DNA ligases are essential enzymes that seal nicks in double-stranded DNA during DNA replication, recombination, and repair. These enzymes utilize ATP to catalyze the formation of a phosphodiester bond betwee...

[]

0

[ "NCBIFAM" ]

[ "NF041331" ]

[ "LigA_Halo" ]

[ 263 ]

1

[ "EC" ]

[ "6.5.1.1" ]

[ "EC:6.5.1.1" ]

1

[]

0

[ "PUB00106335" ]

[ "16420348" ]

[ "ATP- and NAD+-dependent DNA ligases share an essential function in the halophilic archaeon Haloferax volcanii." ]

[ 2006 ]

1

[]

0

null

[ "Halobacteriales" ]

[ 263 ]

1

[]

0

true

Family

ATP-dependent DNA ligase LigA

LigA_Halo

6

IPR054891

54,891

D-2-hydroxyacid dehydrogenase

Dhydh_Halo

Family

262

true

false

This entry represents D-2-hydroxyacid dehydrogenase, an enzyme that catalyzes the stereospecific NAD(P)H-dependent reduction of 2-ketocarboxylic acids into the corresponding D-2-hydroxycarboxylic acids. The enzyme can utilize both NADPH and NADH as reductants, with a marked preference for NADPH. It exhibits broad subst...

[]

0

[ "NCBIFAM" ]

[ "NF041369" ]

[ "Dhydh_Halo" ]

[ 262 ]

1

[]

0

[ "5mh5", "5mh6", "5mha", "8qza", "8qzb", "9ibe" ]

6

[ "PUB00106360" ]

[ "17049749" ]

[ "A new D-2-hydroxyacid dehydrogenase with dual coenzyme-specificity from Haloferax mediterranei, sequence analysis and heterologous overexpression." ]

[ 2006 ]

1

[]

0

null

[ "Halobacteriales" ]

[ 262 ]

1

[]

0

true

Family

D-2-hydroxyacid dehydrogenase

Dhydh_Halo

5

IPR054892

54,892

Lateral flagellin LafA

lat_flg_LafA

Family

282

true

false

Lateral flagellin LafA is a protein found in Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633). It is the subunit protein that polymerizes to form the filaments of bacterial flagella, which are essential for lateral flagellar synthesis and swarming motility. This protein belongs to the bacterial flagellin fa...

[]

0

[ "NCBIFAM" ]

[ "NF038071" ]

[ "lat_flg_LafA" ]

[ 282 ]

1

[]

0

[]

0

[ "PUB00104072", "PUB00104251", "PUB00105550" ]

[ "15170400", "16428388", "4010543" ]

[ "Dual flagellar systems enable motility under different circumstances.", "Analysis of the lateral flagellar gene system of Aeromonas hydrophila AH-3.", "Lateral flagellar antigen of Vibrio alginolyticus and Vibrio harveyi: existence of serovars common to the two species." ]

[ 2004, 2006, 1985 ]

3

[]

0

null

[ "Bacteria", "bioreactor metagenome" ]

[ 281, 1 ]

2

[]

0

true

Family

Lateral flagellin LafA

lat_flg_LafA

3

IPR054893

54,893

Methenyltetrahydrofolate cyclohydrolase

MthfCyhylase

Family

165

true

false

Methenyltetrahydrofolate cyclohydrolase (MTHF cyclohydrolase) is an enzyme that plays a crucial role in the metabolism of one-carbon (C1) and two-carbon (C2) units. This enzyme is part of the cyclodeaminase/cyclohydrolase family and is required for the interconversion of 5,10-methenyltetrahydrofolate to 10-formyltetrah...

[]

0

[ "NCBIFAM" ]

[ "NF045657" ]

[ "MthfCyhylase" ]

[ 165 ]

1

[]

0

[ "7vg4", "7vg5" ]

2

[ "PUB00002257", "PUB00020619", "PUB00154625" ]

[ "7961516", "10215859", "35051495" ]

[ "Genetics of the serine cycle in Methylobacterium extorquens AM1: identification, sequence, and mutation of three new genes involved in C1 assimilation, orf4, mtkA, and mtkB.", "A methenyl tetrahydromethanopterin cyclohydrolase and a methenyl tetrahydrofolate cyclohydrolase in Methylobacterium extorquens AM1.", ...

[ 1994, 1999, 2022 ]

3

[]

0

null

[ "Pseudomonadati", "ecological metagenomes" ]

[ 163, 2 ]

2

[]

0

true

Family

Methenyltetrahydrofolate cyclohydrolase

MthfCyhylase

9

IPR054894

54,894

Assimilatory nitrate reductase NasA

Nitr_red_NasA

Family

225

true

false

Assimilatory nitrate reductase NasA is a key enzyme involved in the first step of nitrate assimilation. It catalyzes the reduction of nitrate to nitrite, using ferredoxin as the electron donor. This enzyme can also use reduced methyl viologen but neither NADPH nor NADH as electron donors. The activity of NasA is inhibi...

[]

0

[ "NCBIFAM" ]

[ "NF041323" ]

[ "Nitr_red_NasA" ]

[ 225 ]

1

[]

0

[]

0

[ "PUB00073482", "PUB00106331" ]

[ "11731152", "16182473" ]

[ "Assimilatory nitrate reductase from the haloarchaeon Haloferax mediterranei: purification and characterisation.", "Identification and transcriptional analysis of nitrate assimilation genes in the halophilic archaeon Haloferax mediterranei." ]

[ 2001, 2005 ]

2

[]

0

null

[ "Halobacteriales" ]

[ 225 ]

1

[]

0

true

Family

Assimilatory nitrate reductase NasA

Nitr_red_NasA

4

IPR054895

54,895

Peptidoglycan-N-acetylglucosamine deacetylase BC_1960

PGN_GlcNAc_Dac_BC_1960

Family

202

true

Peptidoglycan-N-acetylglucosamine deacetylase BC_1960 catalyses the deacetylation of N-acetylglucosamine (GlcNAc) residues in peptidoglycan [ , ]. It also acts on soluble chitin substrates and N-acetylchitooligomers. This protein acts on cell wall peptidoglycan from the Gram-positive bacteria B.cereus and B.subtilis an...

[]

0

[ "NCBIFAM" ]

[ "NF045821" ]

[ "PGN_GlcNAc_Dac" ]

[ 202 ]

1

[]

0

[ "4l1g", "5o6y" ]

2

[ "PUB00093393", "PUB00154681", "PUB00154682" ]

[ "15961396", "18323609", "29983281" ]

[ "Peptidoglycan N-acetylglucosamine deacetylases from Bacillus cereus, highly conserved proteins in Bacillus anthracis.", "Purification, crystallization and preliminary X-ray analysis of the peptidoglycan N-acetylglucosamine deacetylase BC1960 from Bacillus cereus in the presence of its substrate (GlcNAc)6.", "P...

[ 2005, 2008, 2018 ]

3

[ "IPR050248" ]

[]

1

0

1

[ "Bacillaceae" ]

[ 202 ]

1

[]

0

true

Family

Peptidoglycan-N-acetylglucosamine deacetylase BC_1960

PGN_GlcNAc_Dac_BC_1960

2

IPR054896

54,896

Lycopene cyclase, cyanobacteria

CrtY_cyanobact

Family

85

false

This family represents Lycopene beta cyclase (CrtY) mainly found in cyanobacteria. Lycopene cyclase is a key enzyme which converts the acyclic carotenoid lycopene into the cyclic carotenoid beta-carotene [ ]. It is thought that CrtY lycopene cyclases use reduced flavin adenine dinucleotide (redFAD) as a cofactor, which...

[]

0

[ "NCBIFAM" ]

[ "NF045687" ]

[ "LycopCycCtrL" ]

[ 85 ]

1

[]

0

[]

0

[ "PUB00011302", "PUB00011586", "PUB00053852", "PUB00106873", "PUB00106874", "PUB00154704", "PUB00154705" ]

[ "9168123", "8837512", "20178989", "12782726", "25943989", "8344419", "7919981" ]

[ "Cloning, sequencing and expressing the carotenoid biosynthesis genes, lycopene cyclase and phytoene desaturase, from the aerobic photosynthetic bacterium Erythrobacter longus sp. strain Och101 in Escherichia coli.", "Functional analysis of the beta and epsilon lycopene cyclase enzymes of Arabidopsis reveals a me...

[ 1997, 1996, 2010, 2003, 2015, 1993, 1994 ]

7

[ "IPR010108" ]

[]

1

0

1

[ "Bacteria", "Paulinella" ]

[ 81, 4 ]

2

[]

0

true

Family

Lycopene cyclase, cyanobacteria

CrtY_cyanobact

3

IPR054898

54,898

Enoyl-CoA hydratase DpgD

EnCoAhydt_DpgD

Family

226

true

false

Enoyl-CoA hydratase DpgD is a member of the enoyl-CoA hydratase/isomerase family, found in Amycolatopsis orientalis. This enzyme is involved in the biosynthesis of the nonproteinogenic amino acid monomer (S)-3,5-dihydroxyphenylglycine (Dpg), which is crucial for the production of the antibiotics vancomycin and teicopla...

[]

0

[ "NCBIFAM" ]

[ "NF042430" ]

[ "EnCoAhydt_DpgD" ]

[ 226 ]

1

[]

0

[]

0

[ "PUB00014465" ]

[ "11752437" ]

[ "Glycopeptide antibiotic biosynthesis: enzymatic assembly of the dedicated amino acid monomer (S)-3,5-dihydroxyphenylglycine." ]

[ 2001 ]

1

[]

0

null

[ "Bacteria", "prokaryotic environmental samples" ]

[ 223, 3 ]

2

[]

0

true

Family

Enoyl-CoA hydratase DpgD

EnCoAhydt_DpgD

5

IPR054899

54,899

Acidic tetraheme cytochrome c3 TmcA

c3_cytochr_TmcA

Family

86

true

false

Acidic tetraheme cytochrome c3 TmcA is a protein found in Desulfocurvibacter africanus. This protein is involved in electron transfer processes, specifically exchanging electrons with the basic cytochrome c3. The protein is characterized by the presence of four heme groups, which are essential for its function in elect...

[]

0

[ "NCBIFAM" ]

[ "NF045722" ]

[ "c3_cytochr_TmcA" ]

[ 86 ]

1

[]

0

[ "3cao", "3car" ]

2

[ "PUB00154735", "PUB00154758", "PUB00154759" ]

[ "16922512", "8573595", "9392524" ]

[ "The Tmc complex from Desulfovibrio vulgaris hildenborough is involved in transmembrane electron transfer from periplasmic hydrogen oxidation.", "Biochemical studies of the c-type cytochromes of the sulfate reducer Desulfovibrio africanus. Characterization of two tetraheme cytochromes c3 with different specificit...

[ 2006, 1996, 1997 ]

3

[]

0

null

[ "Thermodesulfobacteriota", "hydrocarbon metagenome" ]

[ 85, 1 ]

2

[]

0

true

Family

Acidic tetraheme cytochrome c3 TmcA

c3_cytochr_TmcA

3

IPR054900

54,900

Sulfate respiration complex protein HmcC

sulf_resp_HmcC

Family

95

true

false

This entry represents the sulfate respiration complex protein HmcC, also known as high-molecular-weight cytochrome c (HmcC). HmcC is part of a transmembrane protein complex that facilitates electron flow from the periplasmic hydrogenase to cytoplasmic enzymes involved in sulfate reduction. The protein is encoded by the...

[]

0

[ "NCBIFAM" ]

[ "NF045714" ]

[ "sulf_resp_HmcC" ]

[ 95 ]

1

[]

0

[]

0

[ "PUB00021717", "PUB00154757" ]

[ "12356749", "8335628" ]

[ "Sulfate respiration in Desulfovibrio vulgaris Hildenborough. Structure of the 16-heme cytochrome c HmcA AT 2.5-A resolution and a view of its role in transmembrane electron transfer.", "The hmc operon of Desulfovibrio vulgaris subsp. vulgaris Hildenborough encodes a potential transmembrane redox protein complex....

[ 2002, 1993 ]

2

[]

0

null

[ "Bacteria" ]

[ 95 ]

1

[]

0

true

Family

Sulfate respiration complex protein HmcC

sulf_resp_HmcC

6

IPR054901

54,901

2-isopropylmalate synthase LeuA2

IPMS_Lepto

Family

135

true

false

This entry represents 2-isopropylmalate synthase 2 (LeuA2) from Leptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain 56601). The enzyme catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-ketoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isop...

[]

0

[ "NCBIFAM" ]

[ "NF042434" ]

[ "IPMS_Lepto" ]

[ 135 ]

1

[]

0

[ "4ov4", "4ov9" ]

2

[ "PUB00153491" ]

[ "15292141" ]

[ "Isoleucine biosynthesis in Leptospira interrogans serotype lai strain 56601 proceeds via a threonine-independent pathway." ]

[ 2004 ]

1

[]

0

null

[ "Bacteria" ]

[ 135 ]

1

[]

0

true

Family

2-isopropylmalate synthase LeuA2

IPMS_Lepto

8

IPR054902

54,902

1-phosphofructokinase

pfkB_Halo

Family

145

true

false

1-phosphofructokinase (pfkB) from Haloferax volcanii catalyzes the ATP-dependent phosphorylation of fructose-1-phosphate to fructose-1,6-bisphosphate. This enzyme plays a crucial role in the utilization of fructose as a sole carbon and energy source. It belongs to the carbohydrate kinase PfkB family, which is character...

[]

0

[ "NCBIFAM" ]

[ "NF041320" ]

[ "pfkB_Halo" ]

[ 145 ]

1

[]

0

[]

0

[ "PUB00060540" ]

[ "22493022" ]

[ "Fructose degradation in the haloarchaeon Haloferax volcanii involves a bacterial type phosphoenolpyruvate-dependent phosphotransferase system, fructose-1-phosphate kinase, and class II fructose-1,6-bisphosphate aldolase." ]

[ 2012 ]

1

[]

0

null

[ "Halobacteriales" ]

[ 145 ]

1

[]

0

true

Family

1-phosphofructokinase

pfkB_Halo

7

IPR054903

54,903

Sulfate respiration complex protein HmcE

sulf_resp_HmcE

Family

90

true

false

The sulfate respiration complex protein HmcE is part of a high-molecular-weight cytochrome c (HMWC) complex. This complex, which includes ORF2, ORF3, ORF4, ORF5, and ORF6 in the HMC operon, forms a transmembrane protein assembly that facilitates electron flow from the periplasmic hydrogenase to the cytoplasmic enzymes ...

[]

0

[ "NCBIFAM" ]

[ "NF045716" ]

[ "sulf_resp_HmcE" ]

[ 90 ]

1

[]

0

[]

0

[ "PUB00021717", "PUB00154757" ]

[ "12356749", "8335628" ]

[ "Sulfate respiration in Desulfovibrio vulgaris Hildenborough. Structure of the 16-heme cytochrome c HmcA AT 2.5-A resolution and a view of its role in transmembrane electron transfer.", "The hmc operon of Desulfovibrio vulgaris subsp. vulgaris Hildenborough encodes a potential transmembrane redox protein complex....

[ 2002, 1993 ]

2

[]

0

null

[ "Bacteria", "bioreactor metagenome" ]

[ 89, 1 ]

2

[]

0

true

Family

Sulfate respiration complex protein HmcE

sulf_resp_HmcE

1

IPR054904

54,904

Non-specific acid phosphatase

Acid_Phosphatase_PhoC

Family

150

true

false

This entry represents non-specific acid phosphatases, including major phosphate-irrepressible acid phosphatases from various bacterial species such as Providencia stuartii and Morganella morganii. These enzymes belong to the class A bacterial acid phosphatase family. Acid phosphatases catalyse the hydrolysis of phospha...

[]

0

[ "NCBIFAM" ]

[ "NF045654" ]

[ "Acid_Phosphatase_PhoC" ]

[ 150 ]

1

[]

0

[ "1d2t", "1eoi", "1iw8", "8yc1", "9jq0" ]

5

[ "PUB00003588", "PUB00154799" ]

[ "8081499", "10877772" ]

[ "Characterization and sequence of PhoC, the principal phosphate-irrepressible acid phosphatase of Morganella morganii.", "Phosphorylation of nucleosides by the mutated acid phosphatase from Morganella morganii." ]

[ 1994, 2000 ]

2

[]

0

null

[ "Bacteria", "Beauveria bassiana D1-5" ]

[ 149, 1 ]

2

[]

0

true

Family

Non-specific acid phosphatase

Acid_Phosphatase_PhoC

1

IPR054905

54,905

Succinyl-CoA:mesaconate CoA-transferase

Scnl_mescCoAtase

Family

134

true

false

Succinyl-CoA:mesaconate CoA-transferase is an enzyme involved in the methylaspartate cycle. It catalyzes the transfer of the CoA moiety from succinyl-CoA to mesaconate, generating mesaconyl-CoA (2-methylfumaryl-CoA) and succinate. This enzyme belongs to the CoA-transferase III family. In Haloarcula hispanica, the enzym...

[]

0

[ "NCBIFAM" ]

[ "NF041294" ]

[ "Scnl_mescCoAtase" ]

[ 134 ]

1

[]

0

[]

0

[ "PUB00070126", "PUB00093662" ]

[ "21252347", "28932214" ]

[ "A methylaspartate cycle in haloarchaea.", "Succinyl-CoA:Mesaconate CoA-Transferase and Mesaconyl-CoA Hydratase, Enzymes of the Methylaspartate Cycle in Haloarcula hispanica." ]

[ 2011, 2017 ]

2

[]

0

null

[ "Halobacteriales" ]

[ 134 ]

1

[]

0

true

Family

Succinyl-CoA:mesaconate CoA-transferase

Scnl_mescCoAtase

4

IPR054906

54,906

2,3-Digeranylgeranylglycerophospholipid reductase

DGGGPL_red

Family

86

true

false

This entry represents digeranylgeranylglycerophospholipid reductase, an enzyme involved in the biosynthesis of archaeal membrane lipids. The enzyme catalyzes the reduction of 2,3-digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols). This process invo...

[]

0

[ "NCBIFAM" ]

[ "NF041080" ]

[ "DGGGPL_red" ]

[ 86 ]

1

[]

0

[ "3atq", "3atr", "4opc", "4opd", "4opg", "4opi", "4opl", "4opt", "4opu" ]

9

[ "PUB00106161", "PUB00106162" ]

[ "18375567", "21515284" ]

[ "Specific partial reduction of geranylgeranyl diphosphate by an enzyme from the thermoacidophilic archaeon Sulfolobus acidocaldarius yields a reactive prenyl donor, not a dead-end product.", "Structure and mutation analysis of archaeal geranylgeranyl reductase." ]

[ 2008, 2011 ]

2

[]

0

null

[ "Thermoprotei" ]

[ 86 ]

1

[]

0

true

Family

2,3-Digeranylgeranylglycerophospholipid reductase

DGGGPL_red

2

IPR054907

54,907

(R)-citramalate synthase

CitmalSynth_CimA

Family

122

true

false

This entry represents (R)-citramalate synthase (CimA), an enzyme found in Leptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain 56601). CimA catalyzes the condensation of pyruvate and acetyl-coenzyme A to form (R)-citramalate. The enzyme shows strict substrate specificity for pyruvate and cannot use ...

[]

0

[ "NCBIFAM" ]

[ "NF042433" ]

[ "CitmalSynth_CimA" ]

[ 122 ]

1

[]

0

[]

0

[ "PUB00050683", "PUB00153491" ]

[ "18498255", "15292141" ]

[ "Molecular basis of the substrate specificity and the catalytic mechanism of citramalate synthase from Leptospira interrogans.", "Isoleucine biosynthesis in Leptospira interrogans serotype lai strain 56601 proceeds via a threonine-independent pathway." ]

[ 2008, 2004 ]

2

[]

0

null

[ "Leptospira" ]

[ 122 ]

1

[]

0

true

Family

(R)-citramalate synthase

CitmalSynth_CimA

9

IPR054908

54,908

PTS phosphocarrier protein HPr

PTS-HPr

Family

97

true

false

Phosphocarrier protein HPr is a general (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. T...

[]

0

[ "NCBIFAM" ]

[ "NF041319" ]

[ "PTS-HPr" ]

[ 97 ]

1

[]

0

[]

0

[ "PUB00060540" ]

[ "22493022" ]

[ "Fructose degradation in the haloarchaeon Haloferax volcanii involves a bacterial type phosphoenolpyruvate-dependent phosphotransferase system, fructose-1-phosphate kinase, and class II fructose-1,6-bisphosphate aldolase." ]

[ 2012 ]

1

[]

0

null

[ "Halobacteriales" ]

[ 97 ]

1

[]

0

true

Family

PTS phosphocarrier protein HPr

PTS-HPr

9

IPR054909

54,909

Fructose-bisphosphate aldolase class II

Fbpase2

Family

102

true

false

Fructose-bisphosphate aldolase class II (Fbpase class II) enzymes catalyse the aldol condensation of dihydroxyacetone phosphate (DHAP) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis. These enzymes are required for the utilization o...

[]

0

[ "NCBIFAM" ]

[ "NF041368" ]

[ "Fbpase2" ]

[ 102 ]

1

[]

0

[]

0

[ "PUB00060540" ]

[ "22493022" ]

[ "Fructose degradation in the haloarchaeon Haloferax volcanii involves a bacterial type phosphoenolpyruvate-dependent phosphotransferase system, fructose-1-phosphate kinase, and class II fructose-1,6-bisphosphate aldolase." ]

[ 2012 ]

1

[]

0

null

[ "Methanobacteriota" ]

[ 102 ]

1

[]

0

true

Family

Fructose-bisphosphate aldolase class II

Fbpase2

2

IPR054910

54,910

Olefin beta-lactone synthetase, Shewanella oneidensis

OlefBLtnSynShew

Family

112

true

false

Olefin beta-lactone synthetase is an enzyme involved in the biosynthesis of olefins. It catalyzes the conversion of 2-alkyl-3-hydroxyalkanoic acids to beta-lactones in the presence of ATP. This enzyme belongs to the ATP-dependent AMP-binding enzyme family. In Shewanella oneidensis, the oleABCD gene cluster is responsib...

[]

0

[ "NCBIFAM" ]

[ "NF045785" ]

[ "OlefBLtnSynShew" ]

[ 112 ]

1

[]

0

[]

0

[ "PUB00153446" ]

[ "20418444" ]

[ "Structure, function, and insights into the biosynthesis of a head-to-head hydrocarbon in Shewanella oneidensis strain MR-1." ]

[ 2010 ]

1

[]

0

null

[ "Gammaproteobacteria" ]

[ 112 ]

1

[]

0

true

Family

Olefin beta-lactone synthetase, Shewanella oneidensis

OlefBLtnSynShew

9

IPR054911

54,911

Sulfate respiration complex protein HmcD

sulf_resp_HmcD

Family

71

true

false

The sulfate respiration complex protein HmcD is part of a high-molecular-weight cytochrome c (HMWC) complex involved in electron transfer. This protein is encoded by the DVU_0533 gene in Nitratidesulfovibrio vulgaris (strain ATCC 29579 / DSM 644 / CCUG 34227 / NCIMB 8303 / VKM B-1760 / Hildenborough). HmcD, along with ...

[]

0

[ "NCBIFAM" ]

[ "NF045712" ]

[ "sulf_resp_HmcD" ]

[ 71 ]

1

[]

0

[]

0

[ "PUB00021717", "PUB00154757" ]

[ "12356749", "8335628" ]

[ "Sulfate respiration in Desulfovibrio vulgaris Hildenborough. Structure of the 16-heme cytochrome c HmcA AT 2.5-A resolution and a view of its role in transmembrane electron transfer.", "The hmc operon of Desulfovibrio vulgaris subsp. vulgaris Hildenborough encodes a potential transmembrane redox protein complex....

[ 2002, 1993 ]

2

[ "IPR060724" ]

[]

1

0

1

[ "Bacteria" ]

[ 71 ]

1

[]

0

true

Family

Sulfate respiration complex protein HmcD

sulf_resp_HmcD

6

IPR054912

54,912

Multifunctional alkaline phosphatase PehA

HdlasePehA

Family

106

true

false

This entry represents the multifunctional alkaline phosphatase PehA, a member of the alkaline phosphatase superfamily. PehA exhibits a broad substrate specificity, hydrolyzing phosphate diesters and phosphonate monoesters. It also acts on phosphate mono- and triesters, sulfate monoesters, and sulfonate monoesters. PehA...

[]

0

[ "NCBIFAM" ]

[ "NF045661" ]

[ "HdlasePehA" ]

[ 106 ]

1

[]

0

[ "2vqr", "2w8s", "9gvd", "9gve" ]

4

[ "PUB00049859", "PUB00136051", "PUB00154626" ]

[ "18793651", "20133613", "8824203" ]

[ "A new member of the alkaline phosphatase superfamily with a formylglycine nucleophile: structural and kinetic characterisation of a phosphonate monoester hydrolase/phosphodiesterase from Rhizobium leguminosarum.", "An efficient, multiply promiscuous hydrolase in the alkaline phosphatase superfamily.", "Identif...

[ 2008, 2010, 1996 ]

3

[]

0

null

[ "Pseudomonadota" ]

[ 106 ]

1

[]

0

true

Family

Multifunctional alkaline phosphatase PehA

HdlasePehA

5

IPR054914

54,914

F(420)H(2) dehydrogenase subunit D

F420_dehyd_FpoD

Family

63

true

false

The F(420)H(2) dehydrogenase subunit D is a component of the F(420)H(2) dehydrogenase (FPO complex), which is part of the energy-conserving F(420)H(2):heterodisulfide oxidoreductase system. This system plays a crucial role in the metabolism of methylotrophic methanogens, particularly when these organisms grow on methan...

[]

0

[ "NCBIFAM" ]

[ "NF040602" ]

[ "F420_dehyd_FpoD" ]

[ 63 ]

1

[]

0

[]

0

[ "PUB00009994" ]

[ "10751389" ]

[ "The F420H2 dehydrogenase from Methanosarcina mazei is a Redox-driven proton pump closely related to NADH dehydrogenases." ]

[ 2000 ]

1

[]

0

null

[ "Methanomicrobia", "hydrocarbon metagenome" ]

[ 62, 1 ]

2

[]

0

true

Family

F(420)H(2) dehydrogenase subunit D

F420_dehyd_FpoD

8

IPR054915

54,915

Outer membrane protein OmpV

OmpV

Family

116

true

false

The outer membrane protein OmpV is a member of the MipA/OmpV family, which is found in various Vibrio species, including Vibrio anguillarum and Vibrio cholerae. These proteins are integral components of the bacterial outer membrane and are involved in maintaining membrane integrity and function. The OmpV protein from V...

[]

0

[ "NCBIFAM" ]

[ "NF045789" ]

[ "OmpV" ]

[ 116 ]

1

[]

0

[]

0

[ "PUB00154647" ]

[ "3031428" ]

[ "Nucleotide sequence of ompV, the gene for a major Vibrio cholerae outer membrane protein." ]

[ 1986 ]

1

[]

0

null

[ "Gammaproteobacteria" ]

[ 116 ]

1

[]

0

true

Family

Outer membrane protein OmpV

OmpV

5

IPR054916

54,916

Fatty-acid O-methyltransferase

FAmtase_mtf2

Family

90

true

false

Fatty-acid O-methyltransferase (Mtf2) is an enzyme that modifies the hydroxy group of fatty acids through methylation. Oleate is identified as the most effective fatty acid acceptor for this enzyme. This protein belongs to the methyltransferase superfamily and is found in Mycolicibacterium smegmatis (strain ATCC 700084...

[]

0

[ "NCBIFAM" ]

[ "NF045825" ]

[ "FAmtase_mtf2" ]

[ 90 ]

1

[]

0

[]

0

[ "PUB00154699" ]

[ "12368441" ]

[ "Modification of glycopeptidolipids by an O-methyltransferase of Mycobacterium smegmatis." ]

[ 2002 ]

1

[]

0

null

[ "Actinomycetes" ]

[ 90 ]

1

[]

0

true

Family

Fatty-acid O-methyltransferase

FAmtase_mtf2

1

IPR054917

54,917

Oxalate oxidoreductase subunit alpha

OxalOxred_alpha

Family

41

true

This entry represents Oxalate oxidoreductase subunit alpha also known as OOR subunit alpha. OOR is an enzyme that catalyses the anaerobic oxidation of oxalate using a broad range of electron acceptors, including ferredoxin and the nickel-dependent carbon monoxide dehydrogenase. This enzyme does not require coenzyme A a...

[]

0

[ "NCBIFAM" ]

[ "NF045791" ]

[ "OxalOxredalpha" ]

[ 41 ]

1

[]

0

[ "5c4i", "5exd", "5exe" ]

3

[ "PUB00078738" ]

[ "20956531" ]

[ "Identification and characterization of oxalate oxidoreductase, a novel thiamine pyrophosphate-dependent 2-oxoacid oxidoreductase that enables anaerobic growth on oxalate." ]

[ 2010 ]

1

[ "IPR050722" ]

[]

1

0

1

[ "Bacteria" ]

[ 41 ]

1

[]

0

true

Family

Oxalate oxidoreductase subunit alpha

OxalOxred_alpha

2

IPR054918

54,918

UPF0167 protein CbrC

UPF0167_CbrC

Family

92

true

false

This entry represents the UPF0167 protein CbrC, which is involved in colicin E2 tolerance. The CbrC protein belongs to the UPF0167 family and is found in Escherichia coli (strain K12). The exact function of CbrC is not fully characterized, but it is known to play a role in the bacterial response to colicin E2. Colicins...

[]

0

[ "NCBIFAM" ]

[ "NF040891" ]

[ "UPF0167_CbrC" ]

[ 92 ]

1

[]

0

[]

0

[ "PUB00106048" ]

[ "20418396" ]

[ "YieJ (CbrC) mediates CreBC-dependent colicin E2 tolerance in Escherichia coli." ]

[ 2010 ]

1

[]

0

null

[ "Bacteria", "Trichuris trichiura" ]

[ 91, 1 ]

2

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

UPF0167 protein CbrC

UPF0167_CbrC

2

IPR054919

54,919

Mycoplasma-type histidine triad protein HinT

M_plasma_HinT

Family

111

true

false

This entry represents a Mycoplasma-type histidine triad (HIT) protein, HinT. HIT proteins are characterized by a conserved histidine triad motif (HφHφHφ, where φ is a hydrophobic residue) and are involved in various biochemical processes, including nucleotide binding and hydrolysis. The specific function of this protei...

[]

0

[ "NCBIFAM" ]

[ "NF045834" ]

[ "M_plasma_HinT" ]

[ 111 ]

1

[]

0

[]

0

[ "PUB00035586", "PUB00154805" ]

[ "15904496", "15579213" ]

[ "HinT proteins and their putative interaction partners in Mollicutes and Chlamydiaceae.", "P80, the HinT interacting membrane protein, is a secreted antigen of Mycoplasma hominis." ]

[ 2005, 2004 ]

2

[]

0

null

[ "Mycoplasmatota" ]

[ 111 ]

1

[]

0

true

Family

Mycoplasma-type histidine triad protein HinT

M_plasma_HinT

9

IPR054920

54,920

NAD(P)-dependent benzaldehyde dehydrogenase

BenzalDHMdlD

Family

96

true

false

NAD(P)-dependent benzaldehyde dehydrogenase is an enzyme that catalyzes the conversion of benzaldehyde into benzoate in the (R)-mandelate degradation pathway. This enzyme can utilize either NAD or NADP as a cofactor. It belongs to the aldehyde dehydrogenase family and is encoded by the mdlD gene in Pseudomonas putida. ...

[]

0

[ "NCBIFAM" ]

[ "NF045701" ]

[ "BenzalDHMdlD" ]

[ 96 ]

1

[]

0

[ "5ucd" ]

1

[ "PUB00000334", "PUB00154734" ]

[ "2271624", "12670968" ]

[ "Mandelate pathway of Pseudomonas putida: sequence relationships involving mandelate racemase, (S)-mandelate dehydrogenase, and benzoylformate decarboxylase and expression of benzoylformate decarboxylase in Escherichia coli.", "Identification and characterization of a mandelamide hydrolase and an NAD(P)+-dependen...

[ 1990, 2003 ]

2

[]

0

null

[ "Pseudomonadati" ]

[ 96 ]

1

[]

0

true

Family

NAD(P)-dependent benzaldehyde dehydrogenase

BenzalDHMdlD

6

IPR054921

54,921

Tyrosine isonitrile synthase

TyIsonSynPvcA

Family

128

true

false

L-tyrosine isonitrile synthase is an enzyme involved in the biosynthesis of rhabduscin, a tyrosine derivative that acts as a potent inhibitor of phenoloxidase, a key component of the insect's innate immune system. This enzyme is responsible for the synthesis of the isonitrile group on tyrosine, using the C2 of ribulose...

[]

0

[ "NCBIFAM" ]

[ "NF045653" ]

[ "TyIsonSynPvcA" ]

[ 128 ]

1

[]

0

[ "9dh4", "9dhm", "9dhn" ]

3

[ "PUB00100306" ]

[ "22711807" ]

[ "Small molecule perimeter defense in entomopathogenic bacteria." ]

[ 2012 ]

1

[]

0

null

[ "Enterobacterales" ]

[ 128 ]

1

[]

0

true

Family

Tyrosine isonitrile synthase

TyIsonSynPvcA

2

IPR054922

54,922

FPO subunit F

FPO_su_F

Family

60

true

The F420H2 dehydrogenase subunit F (FpoF) is a component of the F420H2 dehydrogenase (FPO complex), which is part of the energy-conserving F420H2:heterodisulfide oxidoreductase system. This membrane-bound electron transfer system plays a crucial role in the metabolism of methylotrophic methanogens, particularly when th...

[]

0

[ "NCBIFAM" ]

[ "NF040616" ]

[ "F420_dehyd_sub_F" ]

[ 60 ]

1

[]

0

[]

0

[ "PUB00009994" ]

[ "10751389" ]

[ "The F420H2 dehydrogenase from Methanosarcina mazei is a Redox-driven proton pump closely related to NADH dehydrogenases." ]

[ 2000 ]

1

[ "IPR045220" ]

[]

1

0

1

[ "Methanosarcinales" ]

[ 60 ]

1

[]

0

true

Family

FPO subunit F

FPO_su_F

2

IPR054923

54,923

Decorin-binding protein A

Decorin_bind_prot_A

Family

101

true

false

Decorin-binding protein A (DbpA) is a member of the decorin-binding protein family found in Borreliella burgdorferi, the causative agent of Lyme disease. This protein binds to decorin, a component of the extracellular matrix, which may facilitate the adherence of B. burgdorferi to collagen fibers in skin and other tiss...

[]

0

[ "NCBIFAM" ]

[ "NF033713" ]

[ "Decorin_bind_prot_A" ]

[ 101 ]

1

[]

0

[ "2lqu", "2mtc", "2mtd", "4onr", "9bqw" ]

5

[ "PUB00105264", "PUB00105265", "PUB00105266" ]

[ "18507835", "21628660", "25079227" ]

[ "Assessment of decorin-binding protein A to the infectivity of Borrelia burgdorferi in the murine models of needle and tick infection.", "Decorin binding by DbpA and B of Borrelia garinii, Borrelia afzelii, and Borrelia burgdorferi sensu Stricto.", "Strain-specific variation of the decorin-binding adhesin DbpA ...

[ 2008, 2011, 2014 ]

3

[]

0

null

[ "Borreliaceae" ]

[ 101 ]

1

[]

0

true

Family

Decorin-binding protein A

Decorin_bind_prot_A

3