interpro_id string | interpro_numeric_id int64 | name string | short_name string | entry_type string | protein_count int64 | is_llm bool | is_llm_reviewed bool | abstract string | go_ids list | go_terms list | go_categories list | go_count int64 | member_databases list | member_accessions list | member_names list | member_protein_counts list | member_count int64 | external_databases list | external_accessions list | external_xrefs list | external_xref_count int64 | pdb_ids list | structure_count int64 | publication_ids list | pubmed_ids list | publication_titles list | publication_years list | publication_count int64 | parent_ids list | child_ids list | parent_count int64 | child_count int64 | tree_depth float64 | taxonomy_names list | taxonomy_protein_counts list | taxonomy_count int64 | key_species_names list | key_species_protein_counts list | key_species_count int64 | in_entry_list bool | entry_list_type string | entry_list_name string | names_dat_name string | short_names_dat_name string | split_bucket int64 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
IPR055393 | 55,393 | EDC4-like protein pdc1, beta-propeller domain | Beta-prop_EDC4L | Domain | 1,068 | false | false | This entry represents the β-propeller domain of the enhancer of mRNA-decapping protein 4-like protein pdc1 from yeast. This protein is required for the assembly of processing bodies (P-bodies), cytoplasmic RNA granules where mRNA decay occurs [ ]. While evidence suggests pdc1 interacts with proteins Edc3 and Dcp2 throu... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24106"
] | [
"Beta-prop_EDC4L"
] | [
1068
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00154155",
"PUB00155523",
"PUB00155524"
] | [
"24862735",
"23319050",
"24755092"
] | [
"In vitro reconstitution of a cellular phase-transition process that involves the mRNA decapping machinery.",
"Pdc1 functions in the assembly of P bodies in Schizosaccharomyces pombe.",
"Cotranslational protein-RNA associations predict protein-protein interactions."
] | [
2014,
2013,
2014
] | 3 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1068
] | 1 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
1,
2
] | 2 | true | Domain | EDC4-like protein pdc1, beta-propeller domain | EDC4-like protein pdc1, beta-propeller domain | Beta-prop_EDC4L | 5 |
IPR055394 | 55,394 | TiaS, C-terminal zinc ribbon domain | Zn_ribbon_TiaS | Domain | 887 | false | false | This entry represents the zinc ribbon domain (ZRD) found at the the C-terminal of tRNA(Ile2) 2-agmatinylcytidine synthetase TiaS. TiaS is an archaeal ATP-dependent agmatine transferase that catalyses the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2) [1-3]. This modified base specif... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23783"
] | [
"Zn_ribbon_TiaS"
] | [
887
] | 1 | [
"EC"
] | [
"6.3.4.22"
] | [
"EC:6.3.4.22"
] | 1 | [
"3amt",
"3amu",
"4rvz",
"5xob",
"6agg"
] | 5 | [
"PUB00056803",
"PUB00106019",
"PUB00154283"
] | [
"20139989",
"30121296",
"22002223"
] | [
"Agmatine-conjugated cytidine in a tRNA anticodon is essential for AUA decoding in archaea.",
"Structure of tRNA-Modifying Enzyme TiaS and Motions of Its Substrate Binding Zinc Ribbon.",
"Structural basis of tRNA agmatinylation essential for AUA codon decoding."
] | [
2010,
2018,
2011
] | 3 | [] | [] | 0 | 0 | null | [
"Archaea",
"Geodia barretti",
"unclassified sequences"
] | [
859,
1,
27
] | 3 | [] | [] | 0 | true | Domain | TiaS, C-terminal zinc ribbon domain | TiaS, C-terminal zinc ribbon domain | Zn_ribbon_TiaS | 8 |
IPR055395 | 55,395 | Duc1 FFAT-like motif | Duc1_FFAT-like | Conserved_site | 6 | false | false | This entry represents the FFAT-like motif found in proteins such as Duc1 from Schizosaccharomyces pombe [ ], that interact with VAP (VAMP-associated protein) family members like Scs2 and Scs22. The motif is characterised by two adjacent aromatic residues (typically FF, but YF in Duc1) downstream of an acidic tract. It ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24794"
] | [
"Duc1_FFAT_like"
] | [
6
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00155608"
] | [
"39239853"
] | [
"Fission yeast Duc1 links to ER-PM contact sites and influences PM lipid composition and cytokinetic ring anchoring."
] | [
2024
] | 1 | [] | [] | 0 | 0 | null | [
"Parabacteroides distasonis",
"Schizosaccharomyces"
] | [
1,
5
] | 2 | [
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
1
] | 1 | true | Conserved_site | Duc1 FFAT-like motif | Duc1 FFAT-like motif | Duc1_FFAT-like | 5 |
IPR055396 | 55,396 | Domain of unknown function DUF7088 | DUF7088 | Domain | 5,615 | false | false | This domain is found at the N-terminal of a group of poorly characterised bacterial sequences. It is usually found associated with . The function of this domain is unknown. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23357"
] | [
"DUF7088"
] | [
5615
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
5423,
6,
186
] | 3 | [] | [] | 0 | true | Domain | Domain of unknown function DUF7088 | Domain of unknown function DUF7088 | DUF7088 | 9 |
IPR055398 | 55,398 | Bacillithiol biosynthesis BshC, N-terminal Rossmann-like domain | Rossmann-like_BshC | Domain | 4,155 | false | false | This entry represents the N-terminal Rossmann-like domain of the bacillithiol biosynthesis protein BshC from Bacillus subtilis, which has been described as a cysteine-adding enzyme [ , ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF10079"
] | [
"Rossmann-like_BshC"
] | [
4155
] | 1 | [] | [] | [] | 0 | [
"4wbd"
] | 1 | [
"PUB00055031",
"PUB00155578"
] | [
"20308541",
"25496067"
] | [
"Biosynthesis and functions of bacillithiol, a major low-molecular-weight thiol in Bacilli.",
"X-ray crystallographic structure of BshC, a unique enzyme involved in bacillithiol biosynthesis."
] | [
2010,
2015
] | 2 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Metazoa",
"ecological metagenomes"
] | [
4,
4095,
4,
52
] | 4 | [] | [] | 0 | true | Domain | Bacillithiol biosynthesis BshC, N-terminal Rossmann-like domain | Bacillithiol biosynthesis BshC, N-terminal Rossmann-like domain | Rossmann-like_BshC | 7 |
IPR055399 | 55,399 | Bacillithiol biosynthesis BshC, C-terminal coiled-coil domain | CC_BshC | Domain | 4,078 | false | false | This entry represents the C-terminal coiled-coil domain of the bacillithiol biosynthesis protein BshC from Bacillus subtilis, which has been described as a cysteine-adding enzyme. This domain, found associated with , shows a four-helix bundle and is responsible for the dimerisation of the protein [ , ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24850"
] | [
"CC_BshC"
] | [
4078
] | 1 | [] | [] | [] | 0 | [
"4wbd"
] | 1 | [
"PUB00055031",
"PUB00155578"
] | [
"20308541",
"25496067"
] | [
"Biosynthesis and functions of bacillithiol, a major low-molecular-weight thiol in Bacilli.",
"X-ray crystallographic structure of BshC, a unique enzyme involved in bacillithiol biosynthesis."
] | [
2010,
2015
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eumetazoa",
"unclassified sequences"
] | [
4043,
3,
32
] | 3 | [] | [] | 0 | true | Domain | Bacillithiol biosynthesis BshC, C-terminal coiled-coil domain | Bacillithiol biosynthesis BshC, C-terminal coiled-coil domain | CC_BshC | 9 |
IPR055400 | 55,400 | CEMIP, domain X | CEMIP_X | Domain | 3,254 | false | false | This entry represents Domain X of CEMIP, CEMIP2 and closely related sequences [ ]. This domain is located after the β-helix domain. Proteins in this entry are involved in the metabolism of hyaluronic acid (HA) and mediate the depolymerization of high-molecular-weight HA into intermediate-sized fragments [ ], a process ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24605"
] | [
"CEMIP_X"
] | [
3254
] | 1 | [
"EC",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"3.2.1.35",
"PWY-6573",
"R-DDI-2160916",
"R-HSA-2160916",
"R-MMU-2160916"
] | [
"EC:3.2.1.35",
"METACYC:PWY-6573",
"REACTOME:R-DDI-2160916",
"REACTOME:R-HSA-2160916",
"REACTOME:R-MMU-2160916"
] | 5 | [
"8c6i"
] | 1 | [
"PUB00153307",
"PUB00154997",
"PUB00154998",
"PUB00154999"
] | [
"37234743",
"37527776",
"33647313",
"34624311"
] | [
"Structure of the transmembrane protein 2 (TMEM2) ectodomain and its apparent lack of hyaluronidase activity.",
"TMEM2 is a bona fide hyaluronidase possessing intrinsic catalytic activity.",
"The cell surface hyaluronidase TMEM2 regulates cell adhesion and migration via degradation of hyaluronan at focal adhesi... | [
2023,
2023,
2021,
2021
] | 4 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
3254
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
5,
7,
4,
7
] | 4 | true | Domain | CEMIP, domain X | CEMIP, domain X | CEMIP_X | 1 |
IPR055401 | 55,401 | CEMIP, beta-helix domain | CEMIP_beta-hel_dom | Domain | 6,008 | false | false | This entry represents the β-helix domain of CEMIP, CEMIP2 and related sequences [ ]. Proteins in this entry are involved in the metabolism of hyaluronic acid (HA) and mediate the depolymerization of high-molecular-weight HA into intermediate-sized fragments [ ], a process crucial for various physiological functions, in... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24606"
] | [
"CEMIP_beta-hel"
] | [
6008
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-DDI-2160916",
"R-HSA-2160916",
"R-MMU-2160916"
] | [
"REACTOME:R-DDI-2160916",
"REACTOME:R-HSA-2160916",
"REACTOME:R-MMU-2160916"
] | 3 | [
"8c6i"
] | 1 | [
"PUB00153307",
"PUB00154997",
"PUB00154998",
"PUB00154999",
"PUB00155066",
"PUB00155067",
"PUB00155068"
] | [
"37234743",
"37527776",
"33647313",
"34624311",
"18235088",
"20875407",
"30898581"
] | [
"Structure of the transmembrane protein 2 (TMEM2) ectodomain and its apparent lack of hyaluronidase activity.",
"TMEM2 is a bona fide hyaluronidase possessing intrinsic catalytic activity.",
"The cell surface hyaluronidase TMEM2 regulates cell adhesion and migration via degradation of hyaluronan at focal adhesi... | [
2023,
2023,
2021,
2021,
2008,
2011,
2019
] | 7 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Halobacteriales",
"metagenomes"
] | [
357,
5620,
25,
6
] | 4 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
12,
7,
9,
13
] | 4 | true | Domain | CEMIP, beta-helix domain | CEMIP, beta-helix domain | CEMIP_beta-hel_dom | 7 |
IPR055402 | 55,402 | KNTC1, N-terminal | KNTC1_N | Domain | 1,456 | false | false | This entry represents the β-propeller domain found at the N-terminal of KNTC1 (Kinetochore-associated protein 1, also known as ROD) from vertebrates. KNTC1 is the major subunit of the RZZ (ROD-Zwilch-ZW10) complex [ ], which plays a significant role in spindle assembly, kinetochore-microtubule attachment, and spindle p... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24506"
] | [
"KNTC1_N"
] | [
1456
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-141444",
"R-HSA-2467813",
"R-HSA-2500257",
"R-HSA-5663220",
"R-HSA-68877",
"R-HSA-9648025",
"R-MMU-141444",
"R-MMU-2467813",
"R-MMU-2500257",
"R-MMU-5663220",
"R-MMU-68877",
"R-MMU-9648025"
] | [
"REACTOME:R-HSA-141444",
"REACTOME:R-HSA-2467813",
"REACTOME:R-HSA-2500257",
"REACTOME:R-HSA-5663220",
"REACTOME:R-HSA-68877",
"REACTOME:R-HSA-9648025",
"REACTOME:R-MMU-141444",
"REACTOME:R-MMU-2467813",
"REACTOME:R-MMU-2500257",
"REACTOME:R-MMU-5663220",
"REACTOME:R-MMU-68877",
"REACTOME:R-MM... | 12 | [
"7qpg"
] | 1 | [
"PUB00012302",
"PUB00044470",
"PUB00154939",
"PUB00154940"
] | [
"11146660",
"15824131",
"11590237",
"35373361"
] | [
"Human Zw10 and ROD are mitotic checkpoint proteins that bind to kinetochores.",
"ZW10 links mitotic checkpoint signaling to the structural kinetochore.",
"The ZW10 and Rough Deal checkpoint proteins function together in a large, evolutionarily conserved complex targeted to the kinetochore.",
"Structure of th... | [
2000,
2005,
2001,
2022
] | 4 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1456
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
6,
2,
3,
1,
3
] | 5 | true | Domain | KNTC1, N-terminal | KNTC1, N-terminal | KNTC1_N | 9 |
IPR055403 | 55,403 | KNTC1, first ARM-repeats domain | ARM_KNTC1_1st | Domain | 1,923 | false | false | This entry represents the first segment of ARM repeats present in KNTC1 (Kinetochore-associated protein 1, also known as ROD), following the β-propeller domain. KNTC1 is a crucial component of the mitotic checkpoint, ensuring cells do not exit mitosis prematurely [ , , ]. KNTC1 is required for the assembly of essential... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24520"
] | [
"ARM_KNTC1_1st"
] | [
1923
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-141444",
"R-HSA-2467813",
"R-HSA-2500257",
"R-HSA-5663220",
"R-HSA-68877",
"R-HSA-9648025",
"R-MMU-141444",
"R-MMU-2467813",
"R-MMU-2500257",
"R-MMU-5663220",
"R-MMU-68877",
"R-MMU-9648025"
] | [
"REACTOME:R-HSA-141444",
"REACTOME:R-HSA-2467813",
"REACTOME:R-HSA-2500257",
"REACTOME:R-HSA-5663220",
"REACTOME:R-HSA-68877",
"REACTOME:R-HSA-9648025",
"REACTOME:R-MMU-141444",
"REACTOME:R-MMU-2467813",
"REACTOME:R-MMU-2500257",
"REACTOME:R-MMU-5663220",
"REACTOME:R-MMU-68877",
"REACTOME:R-MM... | 12 | [
"7qpg"
] | 1 | [
"PUB00012302",
"PUB00044470",
"PUB00072936",
"PUB00154939",
"PUB00154940"
] | [
"11146660",
"15824131",
"24118572",
"11590237",
"35373361"
] | [
"Human Zw10 and ROD are mitotic checkpoint proteins that bind to kinetochores.",
"ZW10 links mitotic checkpoint signaling to the structural kinetochore.",
"MAG2 and three MAG2-INTERACTING PROTEINs form an ER-localized complex to facilitate storage protein transport in Arabidopsis thaliana.",
"The ZW10 and Rou... | [
2000,
2005,
2013,
2001,
2022
] | 5 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1923
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
7,
1,
6,
2,
3,
1,
3
] | 7 | true | Domain | KNTC1, first ARM-repeats domain | KNTC1, first ARM-repeats domain | ARM_KNTC1_1st | 7 |
IPR055404 | 55,404 | KNTC1, second ARM-repeats domain | ARM_KNTC1_2nd | Domain | 1,452 | false | false | This entry represents the second segment of ARM repeats present in KNTC1 (Kinetochore-associated protein 1, also known as ROD), following the β-propeller domain. KNTC1 is a crucial component of the mitotic checkpoint, ensuring cells do not exit mitosis prematurely [ , , ]. KNTC1 is required for the assembly of essentia... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24516"
] | [
"ARM_KNTC1_2nd"
] | [
1452
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-141444",
"R-HSA-2467813",
"R-HSA-2500257",
"R-HSA-5663220",
"R-HSA-68877",
"R-HSA-9648025",
"R-MMU-141444",
"R-MMU-2467813",
"R-MMU-2500257",
"R-MMU-5663220",
"R-MMU-68877",
"R-MMU-9648025"
] | [
"REACTOME:R-HSA-141444",
"REACTOME:R-HSA-2467813",
"REACTOME:R-HSA-2500257",
"REACTOME:R-HSA-5663220",
"REACTOME:R-HSA-68877",
"REACTOME:R-HSA-9648025",
"REACTOME:R-MMU-141444",
"REACTOME:R-MMU-2467813",
"REACTOME:R-MMU-2500257",
"REACTOME:R-MMU-5663220",
"REACTOME:R-MMU-68877",
"REACTOME:R-MM... | 12 | [
"7qpg"
] | 1 | [
"PUB00012302",
"PUB00044470",
"PUB00154939",
"PUB00154940"
] | [
"11146660",
"15824131",
"11590237",
"35373361"
] | [
"Human Zw10 and ROD are mitotic checkpoint proteins that bind to kinetochores.",
"ZW10 links mitotic checkpoint signaling to the structural kinetochore.",
"The ZW10 and Rough Deal checkpoint proteins function together in a large, evolutionarily conserved complex targeted to the kinetochore.",
"Structure of th... | [
2000,
2005,
2001,
2022
] | 4 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1452
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
6,
2,
1,
2,
3
] | 5 | true | Domain | KNTC1, second ARM-repeats domain | KNTC1, second ARM-repeats domain | ARM_KNTC1_2nd | 7 |
IPR055405 | 55,405 | KNTC1, third ARM-repeats domain | ARM_KNTC1_3rd | Domain | 1,548 | false | false | This entry represents the third segment of ARM repeats present in KNTC1 (Kinetochore-associated protein 1, also known as ROD), following the β-propeller domain. KNTC1 is a crucial component of the mitotic checkpoint, ensuring cells do not exit mitosis prematurely [ , , ]. KNTC1 is required for the assembly of essential... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24515"
] | [
"ARM_KNTC1_3rd"
] | [
1548
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-141444",
"R-HSA-2467813",
"R-HSA-2500257",
"R-HSA-5663220",
"R-HSA-68877",
"R-HSA-9648025",
"R-MMU-141444",
"R-MMU-2467813",
"R-MMU-2500257",
"R-MMU-5663220",
"R-MMU-68877",
"R-MMU-9648025"
] | [
"REACTOME:R-HSA-141444",
"REACTOME:R-HSA-2467813",
"REACTOME:R-HSA-2500257",
"REACTOME:R-HSA-5663220",
"REACTOME:R-HSA-68877",
"REACTOME:R-HSA-9648025",
"REACTOME:R-MMU-141444",
"REACTOME:R-MMU-2467813",
"REACTOME:R-MMU-2500257",
"REACTOME:R-MMU-5663220",
"REACTOME:R-MMU-68877",
"REACTOME:R-MM... | 12 | [
"7qpg"
] | 1 | [
"PUB00012302",
"PUB00044470",
"PUB00154939",
"PUB00154940"
] | [
"11146660",
"15824131",
"11590237",
"35373361"
] | [
"Human Zw10 and ROD are mitotic checkpoint proteins that bind to kinetochores.",
"ZW10 links mitotic checkpoint signaling to the structural kinetochore.",
"The ZW10 and Rough Deal checkpoint proteins function together in a large, evolutionarily conserved complex targeted to the kinetochore.",
"Structure of th... | [
2000,
2005,
2001,
2022
] | 4 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1548
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
6,
3,
1,
3
] | 4 | true | Domain | KNTC1, third ARM-repeats domain | KNTC1, third ARM-repeats domain | ARM_KNTC1_3rd | 6 |
IPR055406 | 55,406 | Maestro/Maestro-like, HEAT-repeats domain | HEAT_Maestro | Domain | 6,870 | false | false | This entry represents a HEAT-repeats domain found in maestro and maestro heat-like repeat-containing proteins, including Maestro heat-like repeat -containing protein family member 2B from mouse (MROH2B, also known as SPIF), which may play a role in the process of sperm capacitation [ ]. This region is found at the C-te... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23227"
] | [
"HEAT_MROH2B_C"
] | [
6870
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00098264"
] | [
"27105888"
] | [
"A novel germ cell protein, SPIF (sperm PKA interacting factor), is essential for the formation of a PKA/TCP11 complex that undergoes conformational and phosphorylation changes upon capacitation."
] | [
2016
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Methanofervidicoccus abyssi",
"bird metagenome"
] | [
5,
6862,
1,
2
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
7,
1,
12,
1,
25,
21,
3,
36,
20
] | 9 | true | Domain | Maestro/Maestro-like, HEAT-repeats domain | Maestro/Maestro-like, HEAT-repeats domain | HEAT_Maestro | 7 |
IPR055407 | 55,407 | Conjugative transposon TraM, C-terminal | TraM_C | Domain | 4,110 | false | false | This domain is found at the C-terminal end of Conjugative transposon TraM protein and similar proteins found in a proposed transfer region of a class of conjugative transposon from bacteroidetes. This domain is predicted to show a β-barrel structure. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12508"
] | [
"Transposon_TraM"
] | [
4110
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Pseudomonadati",
"Tanacetum cinerariifolium",
"metagenomes"
] | [
4052,
1,
57
] | 3 | [] | [] | 0 | true | Domain | Conjugative transposon TraM, C-terminal | Conjugative transposon TraM, C-terminal | TraM_C | 9 |
IPR055408 | 55,408 | MROH2B-like, HEAT-repeats domain | HEAT_MROH2B-like | Domain | 5,646 | false | false | This entry represents a HEAT-repeats domain from Maestro heat-like repeat-containing protein family member 2B (MROH2B, also known as SPIF and MRO2B) from mouse, Protein SHOOT GRAVITROPISM 6 from Arabidopsis thaliana (SGR6) and similar sequences mainly found in animals and plants. SPIF may play a role in the process of ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23210"
] | [
"HEAT_Maestro_2"
] | [
5646
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00098263",
"PUB00098264"
] | [
"24486761",
"27105888"
] | [
"A unique HEAT repeat-containing protein SHOOT GRAVITROPISM6 is involved in vacuolar membrane dynamics in gravity-sensing cells of Arabidopsis inflorescence stem.",
"A novel germ cell protein, SPIF (sperm PKA interacting factor), is essential for the formation of a PKA/TCP11 complex that undergoes conformational ... | [
2014,
2016
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"bird metagenome"
] | [
5645,
1
] | 2 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
9,
1,
12,
2,
32,
21,
2,
28,
12
] | 9 | true | Domain | MROH2B-like, HEAT-repeats domain | MROH2B-like, HEAT-repeats domain | HEAT_MROH2B-like | 4 |
IPR055409 | 55,409 | FAM234A/B, beta-propeller | Beta-prop_FAM234A_B | Domain | 3,250 | false | false | This entry represents the β-propeller domain found in FAM234A/B proteins from mammals and related sequences, whose function is unknown. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23727"
] | [
"Beta-prop_FAM234A_B"
] | [
3250
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Metazoa"
] | [
43,
3207
] | 2 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
6,
11,
5,
8
] | 5 | true | Domain | FAM234A/B, beta-propeller | FAM234A/B, beta-propeller | Beta-prop_FAM234A_B | 8 |
IPR055410 | 55,410 | CAF1B/HIR1, beta-propeller domain | Beta-prop_CAF1B_HIR1 | Domain | 9,282 | false | false | This entry represents the β-propeller domain found in chromatin assembly factor 1 subunit CAF1B (also known as p60 subunit) from animals, and its homologues Cac2 from yeasts and FAS from plants. These proteins are involved in DNA synthesis-coupled chromatic assembly in S-phase and chromatin assembly following DNA repai... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24105"
] | [
"Beta-prop_CAF1B_HIR1"
] | [
9282
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-CEL-2559584",
"R-HSA-2559584",
"R-HSA-9821993",
"R-MMU-2559584",
"R-SCE-2559584"
] | [
"REACTOME:R-CEL-2559584",
"REACTOME:R-HSA-2559584",
"REACTOME:R-HSA-9821993",
"REACTOME:R-MMU-2559584",
"REACTOME:R-SCE-2559584"
] | 5 | [
"7y5k",
"7y5l",
"7y5o",
"7y5u",
"7y5v",
"7y60",
"7y61",
"8ghl",
"8ghm",
"8ghn",
"8iqf",
"8iqg",
"8j6s",
"8j6t"
] | 14 | [
"PUB00043990",
"PUB00062043",
"PUB00098126",
"PUB00098127",
"PUB00098128",
"PUB00155516",
"PUB00155517"
] | [
"16980972",
"19029251",
"9813080",
"18045841",
"20699390",
"27221973",
"15121850"
] | [
"Structure of a human ASF1a-HIRA complex and insights into specificity of histone chaperone complex assembly.",
"Human UBN1 is an ortholog of yeast Hpc2p and has an essential role in the HIRA/ASF1a chromatin-remodeling pathway in senescent cells.",
"Recruitment of phosphorylated chromatin assembly factor 1 to c... | [
2006,
2009,
1998,
2008,
2010,
2016,
2004
] | 7 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota"
] | [
26,
9256
] | 2 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
7,
3,
3,
6,
5,
4,
2,
2,
9,
2,
2,
16
] | 12 | true | Domain | CAF1B/HIR1, beta-propeller domain | CAF1B/HIR1, beta-propeller domain | Beta-prop_CAF1B_HIR1 | 6 |
IPR055411 | 55,411 | F-box/LRR-repeat protein 15/At3g58940/PEG3-like, LRR domain | LRR_FXL15/At3g58940/PEG3-like | Domain | 29,235 | false | false | This entry represents a domain consisting of leucine-rich repeats (LRRs) mainly found in plant proteins, such as F-box/LRR-repeat protein At3g58940, At1g56610, F-box protein At1g60400 (also known as PEG3) from Arabidopsis thaliana among others. Some of the plant members have been described as components of SCF (ASK-cul... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24758"
] | [
"LRR_At5g56370"
] | [
29235
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-MMU-8951664",
"R-MMU-983168",
"R-RNO-8951664",
"R-RNO-983168"
] | [
"REACTOME:R-MMU-8951664",
"REACTOME:R-MMU-983168",
"REACTOME:R-RNO-8951664",
"REACTOME:R-RNO-983168"
] | 4 | [] | 0 | [
"PUB00147666",
"PUB00155968"
] | [
"21572392",
"26344545"
] | [
"SCFFBXL¹⁵ regulates BMP signalling by directing the degradation of HECT-type ubiquitin ligase Smurf1.",
"Paternally expressed imprinted genes establish postzygotic hybridization barriers in Arabidopsis thaliana."
] | [
2011,
2015
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"marine metagenome"
] | [
51,
29183,
1
] | 3 | [
"Arabidopsis thaliana",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
664,
3,
1,
294,
2,
124
] | 6 | true | Domain | F-box/LRR-repeat protein 15/At3g58940/PEG3-like, LRR domain | F-box/LRR-repeat protein 15/At3g58940/PEG3-like, LRR domain | LRR_FXL15/At3g58940/PEG3-like | 7 |
IPR055412 | 55,412 | Root UVB sensitive protein, C-terminal | UVB_sens_C | Domain | 5,120 | false | false | This domain is found at the C terminus of a group of root UVB sensitive plant proteins and their eukaryotic RUS homologues. It is predicted to adopt an α/β configuration. This domain is found associated with . This entry includes root UVB sensitive proteins and their homologues. In Arabidopsis thaliana, proteins in thi... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24160"
] | [
"UVB_sens_C"
] | [
5120
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00057512",
"PUB00057513",
"PUB00066759",
"PUB00072694",
"PUB00154596"
] | [
"19515790",
"20562234",
"21511809",
"19075229",
"31268148"
] | [
"ROOT UV-B SENSITIVE2 acts with ROOT UV-B SENSITIVE1 in a root ultraviolet B-sensing pathway.",
"Arabidopsis ROOT UVB SENSITIVE2/WEAK AUXIN RESPONSE1 is required for polar auxin transport.",
"root uv-b sensitive mutants are suppressed by specific mutations in ASPARTATE AMINOTRANSFERASE2 and by exogenous vitamin... | [
2009,
2010,
2011,
2008,
2019
] | 5 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Pseudomonadota"
] | [
5113,
7
] | 2 | [
"Arabidopsis thaliana",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
25,
9,
2,
4,
3,
13,
4,
44
] | 8 | true | Domain | Root UVB sensitive protein, C-terminal | Root UVB sensitive protein, C-terminal | UVB_sens_C | 6 |
IPR055413 | 55,413 | Matrix protein, C-terminal, Paramyxoviridae | Matrix_Paramyxo_C | Domain | 2,042 | false | false | This entry represents the C-terminal domain found in a variety of paramyxoviruses such as morbillivirus, paramyxovirus, pneumovirus M proteins. The C-terminal domain of the NDV matrix protein, similar to the N-terminal domain, adopts a β-sandwich fold with β-strands in the opposing β-sheets arranged approximately ortho... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23765"
] | [
"Matrix_Paramyxo_C"
] | [
2042
] | 1 | [] | [] | [] | 0 | [
"4g1g",
"4g1l",
"4g1o",
"6bk6",
"7sks",
"7skt",
"7sku"
] | 7 | [
"PUB00062701",
"PUB00155732"
] | [
"22891297",
"29695428"
] | [
"Structure and assembly of a paramyxovirus matrix protein.",
"Electrostatic Interactions between Hendra Virus Matrix Proteins Are Required for Efficient Virus-Like-Particle Assembly."
] | [
2012,
2018
] | 2 | [] | [] | 0 | 0 | null | [
"Candidatus Clostridium helianthi",
"Paralichthys olivaceus",
"Paramyxoviridae"
] | [
1,
1,
2040
] | 3 | [] | [] | 0 | true | Domain | Matrix protein, C-terminal, Paramyxoviridae | Matrix protein, C-terminal, Paramyxoviridae | Matrix_Paramyxo_C | 1 |
IPR055414 | 55,414 | Disease resistance R13L4/SHOC-2-like, LRR domain | LRR_R13L4/SHOC2-like | Domain | 158,468 | false | false | This entry represents a region containing leucine-rich repeats found mainly in plants, including a variety of plant resistance proteins, such as disease resistance RPP13-like protein 4 (R13L4) from Arabidopsis. R13L4 is a CC-NB-LRR receptor-like protein required for recognition of pathogenic bacteria type III effectors... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23598"
] | [
"LRR_14"
] | [
158468
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-5673000",
"R-CEL-438066",
"R-CEL-5223345",
"R-CEL-5673000",
"R-CEL-6798695",
"R-CEL-9013406",
"R-DDI-193648",
"R-DDI-446388",
"R-DDI-5675482",
"R-DDI-9013148",
"R-DDI-9013149",
"R-DME-438066",
"R-DME-5223345",
"R-DME-6798695",
"R-DME-9013406",
"R-DRE-5673000",
"R-DRE-9013406",... | [
"REACTOME:R-BTA-5673000",
"REACTOME:R-CEL-438066",
"REACTOME:R-CEL-5223345",
"REACTOME:R-CEL-5673000",
"REACTOME:R-CEL-6798695",
"REACTOME:R-CEL-9013406",
"REACTOME:R-DDI-193648",
"REACTOME:R-DDI-446388",
"REACTOME:R-DDI-5675482",
"REACTOME:R-DDI-9013148",
"REACTOME:R-DDI-9013149",
"REACTOME:R... | 88 | [
"4lsx",
"4m7e",
"4mn8",
"4mna",
"4q3g",
"4q3i",
"4tzh",
"4u06",
"4u08",
"4u09",
"4z5w",
"4z61",
"4z62",
"5gij",
"5gqr",
"5gr9",
"5hyx",
"5hz0",
"5hz1",
"5hz3",
"5iyx",
"5jfi",
"5jfk",
"5xjo",
"5xjx",
"5xkj",
"5zsu",
"6djb",
"6fg8",
"6fnw",
"6g8z",
"6g9l"... | 125 | [
"PUB00098445",
"PUB00098447",
"PUB00155969",
"PUB00155970",
"PUB00155971",
"PUB00155972",
"PUB00155973",
"PUB00155974",
"PUB00155975",
"PUB00155976",
"PUB00155977",
"PUB00155978",
"PUB00155979",
"PUB00155980",
"PUB00155981"
] | [
"28288096",
"28499073",
"20368970",
"26355215",
"28652264",
"30948526",
"30948527",
"22730405",
"25137548",
"27694184",
"30361234",
"35768504",
"35830882",
"35831509",
"36175670"
] | [
"Expanded type III effector recognition by the ZAR1 NLR protein using ZED1-related kinases.",
"Arabidopsis ZED1-related kinases mediate the temperature-sensitive intersection of immune response and growth homeostasis.",
"Allele-specific virulence attenuation of the Pseudomonas syringae HopZ1a type III effector ... | [
2017,
2017,
2010,
2015,
2017,
2019,
2019,
2012,
2014,
2016,
2018,
2022,
2022,
2022,
2022
] | 15 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
52,
4490,
153469,
46,
411
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
1155,
8,
149,
33,
66,
43,
2,
1587,
70,
1,
1,
602
] | 12 | true | Domain | Disease resistance R13L4/SHOC-2-like, LRR domain | Disease resistance R13L4/SHOC-2-like, LRR domain | LRR_R13L4/SHOC2-like | 1 |
IPR055415 | 55,415 | SV2A/B/C, luminal domain | LD_SV2 | Domain | 4,331 | false | false | This entry represents the luminal domain found in synaptic vesicle protein 2 A, B and C (SV2A, SV2B and SV2C) from animals. SV2s are specific to vesicles that undergo calcium-regulated secretion and are essential for normal nervous system function, particularly for neurotransmission [ ]. SV2s have also been identified ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23894"
] | [
"LD_SV2"
] | [
4331
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-5250955",
"R-HSA-5250968",
"R-HSA-5250981",
"R-HSA-5250992"
] | [
"REACTOME:R-HSA-5250955",
"REACTOME:R-HSA-5250968",
"REACTOME:R-HSA-5250981",
"REACTOME:R-HSA-5250992"
] | 4 | [
"4jra",
"5jlv",
"5jmc",
"5moy",
"6es1",
"7uia",
"7uib",
"8jlc",
"8jle",
"8jlf",
"8jlg",
"8jlh",
"8jli",
"8js8",
"8js9",
"8k77",
"8uo8",
"8uo9",
"8uoa",
"8yf0",
"8yf1",
"9f1r",
"9f2b",
"9f2j",
"9f2y",
"9f3c",
"9fyq",
"9fyr",
"9ntc",
"9pc9",
"9pcb"
] | 31 | [
"PUB00052050",
"PUB00142517",
"PUB00155705"
] | [
"19476346",
"24240280",
"30826548"
] | [
"Glycosylated SV2 and gangliosides as dual receptors for botulinum neurotoxin serotype F.",
"Structural basis for recognition of synaptic vesicle protein 2C by botulinum neurotoxin A.",
"Synaptic vesicle protein 2: A multi-faceted regulator of secretion."
] | [
2009,
2014,
2019
] | 3 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"ecological metagenomes"
] | [
252,
4077,
2
] | 3 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
7,
5,
5,
12
] | 4 | true | Domain | SV2A/B/C, luminal domain | SV2A/B/C, luminal domain | LD_SV2 | 6 |
IPR055416 | 55,416 | Leucine--tRNA ligase, RagD-binding domain | RBD_LARS1 | Domain | 4,201 | false | false | This is the RagD-binding domain (RBD) of human Leucine--tRNA ligase, a synthetase that catalyses the specific attachment of leucine to its cognate tRNA. This domain shows three α-helices [ , ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24810"
] | [
"RBD_LARS1"
] | [
4201
] | 1 | [
"EC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"6.1.1.4",
"R-DDI-9856649",
"R-HSA-2408522",
"R-HSA-379716",
"R-HSA-9856649",
"R-MMU-9856649"
] | [
"EC:6.1.1.4",
"REACTOME:R-DDI-9856649",
"REACTOME:R-HSA-2408522",
"REACTOME:R-HSA-379716",
"REACTOME:R-HSA-9856649",
"REACTOME:R-MMU-9856649"
] | 6 | [
"6kid",
"6kie",
"6kqy",
"6kr7",
"6lpf",
"6lr6"
] | 6 | [
"PUB00154461",
"PUB00154462"
] | [
"32232361",
"33910001"
] | [
"Molecular basis of the multifaceted functions of human leucyl-tRNA synthetase in protein synthesis and beyond.",
"Leucine-sensing mechanism of leucyl-tRNA synthetase 1 for mTORC1 activation."
] | [
2020,
2021
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
4201
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
5,
1,
1,
3,
16,
4,
1,
6,
3,
1,
1,
6
] | 12 | true | Domain | Leucine--tRNA ligase, RagD-binding domain | Leucine--tRNA ligase, RagD-binding domain | RBD_LARS1 | 7 |
IPR055417 | 55,417 | Ubiquitin fusion degradation protein UFD1, N-terminal subdomain 1 | UFD1_N1 | Domain | 8,090 | false | false | This entry corresponds to the first subdomain of UFD1 UT3 which forms a double-psi β-barrel fold. Ufd1 is a 40kDa protein involved in the ubiquitin fusion degradation (UFD) pathway, which recognises post-translational ubiquitin-protein conjugates for degradation, and is essential for vegetative cell viability [ ]. Stru... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF03152"
] | [
"UFD1_N1"
] | [
8090
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-CEL-110320",
"R-CEL-8951664",
"R-CEL-9755511",
"R-DDI-8951664",
"R-DDI-9755511",
"R-DME-110320",
"R-DME-5689880",
"R-DME-8951664",
"R-DME-9755511",
"R-HSA-110320",
"R-HSA-5689880",
"R-HSA-8951664",
"R-HSA-9755511",
"R-MMU-110320",
"R-MMU-5689880",
"R-MMU-8951664",
"R-MMU-9755511",... | [
"REACTOME:R-CEL-110320",
"REACTOME:R-CEL-8951664",
"REACTOME:R-CEL-9755511",
"REACTOME:R-DDI-8951664",
"REACTOME:R-DDI-9755511",
"REACTOME:R-DME-110320",
"REACTOME:R-DME-5689880",
"REACTOME:R-DME-8951664",
"REACTOME:R-DME-9755511",
"REACTOME:R-HSA-110320",
"REACTOME:R-HSA-5689880",
"REACTOME:R... | 27 | [
"1zc1",
"2yuj",
"8dar",
"8das",
"8dat",
"8dau",
"8dav",
"8daw"
] | 8 | [
"PUB00007707",
"PUB00007708",
"PUB00038834",
"PUB00085171",
"PUB00085175",
"PUB00085176",
"PUB00155902",
"PUB00155903"
] | [
"7615550",
"9063746",
"16004872",
"20206597",
"28355556",
"26471729",
"11781570",
"12847084"
] | [
"A proteolytic pathway that recognizes ubiquitin as a degradation signal.",
"UFD1L, a developmentally expressed ubiquitination gene, is deleted in CATCH 22 syndrome.",
"Ufd1 exhibits the AAA-ATPase fold with two distinct ubiquitin interaction sites.",
"The Cdc48-Ufd1-Npl4 complex is central in ubiquitin-prote... | [
1995,
1997,
2005,
2010,
2017,
2015,
2001,
2003
] | 8 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Imitervirales",
"metagenomes"
] | [
8074,
3,
13
] | 3 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
20,
2,
1,
1,
7,
5,
2,
14,
4,
1,
1,
18
] | 12 | true | Domain | Ubiquitin fusion degradation protein UFD1, N-terminal subdomain 1 | Ubiquitin fusion degradation protein UFD1, N-terminal subdomain 1 | UFD1_N1 | 3 |
IPR055418 | 55,418 | Ubiquitin fusion degradation protein UFD1, N-terminal subdomain 2 | UFD1_N2 | Domain | 8,247 | false | false | This entry corresponds to the second subdomain of UFD1 UT3 which has a mixed α/β roll structure [ ]. Ufd1 is a 40kDa protein involved in the ubiquitin fusion degradation (UFD) pathway, which recognises post-translational ubiquitin-protein conjugates for degradation, and is essential for vegetative cell viability [ ]. S... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24842"
] | [
"UFD1_N2"
] | [
8247
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-CEL-110320",
"R-CEL-8951664",
"R-CEL-9755511",
"R-DDI-8951664",
"R-DDI-9755511",
"R-DME-110320",
"R-DME-5689880",
"R-DME-8951664",
"R-DME-9755511",
"R-HSA-110320",
"R-HSA-5689880",
"R-HSA-8951664",
"R-HSA-9755511",
"R-MMU-110320",
"R-MMU-5689880",
"R-MMU-8951664",
"R-MMU-9755511",... | [
"REACTOME:R-CEL-110320",
"REACTOME:R-CEL-8951664",
"REACTOME:R-CEL-9755511",
"REACTOME:R-DDI-8951664",
"REACTOME:R-DDI-9755511",
"REACTOME:R-DME-110320",
"REACTOME:R-DME-5689880",
"REACTOME:R-DME-8951664",
"REACTOME:R-DME-9755511",
"REACTOME:R-HSA-110320",
"REACTOME:R-HSA-5689880",
"REACTOME:R... | 27 | [
"1zc1",
"2yuj",
"8dar",
"8das",
"8dat",
"8dau",
"8dav",
"8daw"
] | 8 | [
"PUB00007707",
"PUB00007708",
"PUB00038834",
"PUB00085171",
"PUB00085175",
"PUB00085176",
"PUB00155902",
"PUB00155903"
] | [
"7615550",
"9063746",
"16004872",
"20206597",
"28355556",
"26471729",
"11781570",
"12847084"
] | [
"A proteolytic pathway that recognizes ubiquitin as a degradation signal.",
"UFD1L, a developmentally expressed ubiquitination gene, is deleted in CATCH 22 syndrome.",
"Ufd1 exhibits the AAA-ATPase fold with two distinct ubiquitin interaction sites.",
"The Cdc48-Ufd1-Npl4 complex is central in ubiquitin-prote... | [
1995,
1997,
2005,
2010,
2017,
2015,
2001,
2003
] | 8 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Mimiviridae sp. ChoanoV1",
"metagenomes"
] | [
8234,
1,
12
] | 3 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
21,
2,
1,
1,
6,
4,
2,
14,
4,
1,
1,
17
] | 12 | true | Domain | Ubiquitin fusion degradation protein UFD1, N-terminal subdomain 2 | Ubiquitin fusion degradation protein UFD1, N-terminal subdomain 2 | UFD1_N2 | 8 |
IPR055419 | 55,419 | Periplakin/Envoplakin, N-terminal | Spectrin_PEPL/EVPL | Domain | 2,277 | false | false | This domain consists of spectrin-like repeats found at the N-terminal in human Periplakin and related vertebrate proteins including Envoplakin and Envoplakin-like proteins. Periplakin is a component of the cornified envelope of keratinocytes and, together with envoplakin, forms a network radiating from desmosomes that ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23160"
] | [
"Spectrin_1st_PEPL"
] | [
2277
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-6809371",
"R-HSA-8851680",
"R-MMU-6809371",
"R-MMU-8851680"
] | [
"REACTOME:R-HSA-6809371",
"REACTOME:R-HSA-8851680",
"REACTOME:R-MMU-6809371",
"REACTOME:R-MMU-8851680"
] | 4 | [] | 0 | [
"PUB00155847"
] | [
"9412476"
] | [
"Periplakin, a novel component of cornified envelopes and desmosomes that belongs to the plakin family and forms complexes with envoplakin."
] | [
1997
] | 1 | [] | [] | 0 | 0 | null | [
"Bilateria"
] | [
2277
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
5,
9,
5,
7
] | 4 | true | Domain | Periplakin/Envoplakin, N-terminal | Periplakin/Envoplakin, N-terminal | Spectrin_PEPL/EVPL | 8 |
IPR055420 | 55,420 | Trafficking protein particle complex II-specific subunit 65, IgD3 | IgD3_Trs65 | Domain | 1,546 | false | false | This entry represents the IgD3 domain of Trs65 [ ] and similar fungal proteins. This entry includes Trafficking protein particle complex II-specific subunit 65 from Saccharomyces cerevisiae (Trp65), an essential subunit of the TRAPP Golgi trafficking complex [ , , , , ]. TRAPP subunits are found in three forms-core TRA... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12735"
] | [
"IgD3_Trs65"
] | [
1546
] | 1 | [] | [] | [] | 0 | [
"7e2c",
"7e2d",
"7e8s",
"7e8t",
"7e93",
"7e94",
"7ea3",
"7u05",
"7u06"
] | 9 | [
"PUB00020479",
"PUB00055557",
"PUB00055565",
"PUB00056101",
"PUB00153720"
] | [
"9564032",
"11239471",
"18801063",
"17475775",
"35080977"
] | [
"TRAPP, a highly conserved novel complex on the cis-Golgi that mediates vesicle docking and fusion.",
"TRAPP I implicated in the specificity of tethering in ER-to-Golgi transport.",
"The TRAPP complex: insights into its architecture and function.",
"The role of Trs65 in the Ypt/Rab guanine nucleotide exchange... | [
1998,
2001,
2008,
2007,
2022
] | 5 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1546
] | 1 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)"
] | [
2,
1
] | 2 | true | Domain | Trafficking protein particle complex II-specific subunit 65, IgD3 | Trafficking protein particle complex II-specific subunit 65, IgD3 | IgD3_Trs65 | 6 |
IPR055421 | 55,421 | Transmembrane protein TMEM132, cohesin-like domain | TMEM132_3rd | Domain | 5,223 | false | false | This is the third domain of TMEM132 family, which includes TMEM132A-E. This is a β-sandwich domain closely related to cohesin, which may be involved in cellular adhesion [ ]. The transmembrane protein 132 family (TMEM132) consists of TMEM132A, TMEM132B, TMEM132C, TMEM132D, TMEM132E. These are transmembrane proteins tha... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23039"
] | [
"TMEM132_3rd"
] | [
5223
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-381426",
"R-HSA-8957275",
"R-MMU-381426",
"R-MMU-8957275",
"R-RNO-381426",
"R-RNO-8957275"
] | [
"REACTOME:R-HSA-381426",
"REACTOME:R-HSA-8957275",
"REACTOME:R-MMU-381426",
"REACTOME:R-MMU-8957275",
"REACTOME:R-RNO-381426",
"REACTOME:R-RNO-8957275"
] | 6 | [] | 0 | [
"PUB00060383",
"PUB00060384",
"PUB00153373",
"PUB00153374",
"PUB00153375"
] | [
"12514190",
"16806201",
"25331638",
"29088312",
"33726789"
] | [
"Cloning and characterization of a novel GRP78-binding protein in the rat brain.",
"GRP78-binding protein regulates cAMP-induced glial fibrillary acidic protein expression in rat C6 glioblastoma cells.",
"Whole-exome sequencing identifies a variant in TMEM132E causing autosomal-recessive nonsyndromic hearing lo... | [
2003,
2006,
2015,
2018,
2021
] | 5 | [] | [] | 0 | 0 | null | [
"Bilateria"
] | [
5223
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
20,
3,
10,
9,
18
] | 5 | true | Domain | Transmembrane protein TMEM132, cohesin-like domain | Transmembrane protein TMEM132, cohesin-like domain | TMEM132_3rd | 8 |
IPR055422 | 55,422 | Transmembrane protein TMEM132, second Ig-like domain | Ig_TMEM132_2nd | Domain | 4,639 | false | false | This entry represents the second Ig-like domain found in TMEM132 family of proteins. The transmembrane protein 132 family (TMEM132) consists of TMEM132A, TMEM132B, TMEM132C, TMEM132D, TMEM132E. These are transmembrane proteins that regulate neuronal structure and function. In mammalian cells, they may regulate NAP1 in ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23481"
] | [
"Ig_TMEM132_2nd"
] | [
4639
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-381426",
"R-HSA-8957275",
"R-MMU-381426",
"R-MMU-8957275",
"R-RNO-381426",
"R-RNO-8957275"
] | [
"REACTOME:R-HSA-381426",
"REACTOME:R-HSA-8957275",
"REACTOME:R-MMU-381426",
"REACTOME:R-MMU-8957275",
"REACTOME:R-RNO-381426",
"REACTOME:R-RNO-8957275"
] | 6 | [] | 0 | [
"PUB00060383",
"PUB00060384",
"PUB00153373",
"PUB00153374",
"PUB00153375"
] | [
"12514190",
"16806201",
"25331638",
"29088312",
"33726789"
] | [
"Cloning and characterization of a novel GRP78-binding protein in the rat brain.",
"GRP78-binding protein regulates cAMP-induced glial fibrillary acidic protein expression in rat C6 glioblastoma cells.",
"Whole-exome sequencing identifies a variant in TMEM132E causing autosomal-recessive nonsyndromic hearing lo... | [
2003,
2006,
2015,
2018,
2021
] | 5 | [] | [] | 0 | 0 | null | [
"Bilateria"
] | [
4639
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
20,
7,
9,
18
] | 4 | true | Domain | Transmembrane protein TMEM132, second Ig-like domain | Transmembrane protein TMEM132, second Ig-like domain | Ig_TMEM132_2nd | 4 |
IPR055424 | 55,424 | Transmembrane protein TMEM132, sixth domain | Ig_TMEM132_6th | Domain | 5,536 | false | false | This is the sixth domain of TMEM132 family of proteins. This domain includes a β-hairpin extension which is swapped with the N-terminal domain to complete its β-sandwich fold. The transmembrane protein 132 family (TMEM132) consists of TMEM132A, TMEM132B, TMEM132C, TMEM132D, TMEM132E. These are transmembrane proteins th... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23487"
] | [
"Ig_TMEM132_6th"
] | [
5536
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-CEL-381426",
"R-CEL-8957275",
"R-HSA-381426",
"R-HSA-8957275",
"R-MMU-381426",
"R-MMU-8957275",
"R-RNO-381426",
"R-RNO-8957275"
] | [
"REACTOME:R-CEL-381426",
"REACTOME:R-CEL-8957275",
"REACTOME:R-HSA-381426",
"REACTOME:R-HSA-8957275",
"REACTOME:R-MMU-381426",
"REACTOME:R-MMU-8957275",
"REACTOME:R-RNO-381426",
"REACTOME:R-RNO-8957275"
] | 8 | [] | 0 | [
"PUB00060383",
"PUB00060384",
"PUB00153373",
"PUB00153374",
"PUB00153375"
] | [
"12514190",
"16806201",
"25331638",
"29088312",
"33726789"
] | [
"Cloning and characterization of a novel GRP78-binding protein in the rat brain.",
"GRP78-binding protein regulates cAMP-induced glial fibrillary acidic protein expression in rat C6 glioblastoma cells.",
"Whole-exome sequencing identifies a variant in TMEM132E causing autosomal-recessive nonsyndromic hearing lo... | [
2003,
2006,
2015,
2018,
2021
] | 5 | [] | [] | 0 | 0 | null | [
"Bilateria"
] | [
5536
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
21,
3,
10,
9,
17
] | 6 | true | Domain | Transmembrane protein TMEM132, sixth domain | Transmembrane protein TMEM132, sixth domain | Ig_TMEM132_6th | 4 |
IPR055426 | 55,426 | Trafficking protein particle complex II-specific subunit 65, IgD2 | IgD2_Trs65 | Domain | 60 | false | false | This entry represents the IgD2 domain of Trs65 [ ] and similar proteins from Saccharomycetales. This entry includes Trafficking protein particle complex II-specific subunit 65 from Saccharomyces cerevisiae (Trp65), an essential subunit of the TRAPP Golgi trafficking complex [ , , , , ]. TRAPP subunits are found in thre... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23646"
] | [
"IgD2_Trs65"
] | [
60
] | 1 | [] | [] | [] | 0 | [
"7e2c",
"7e2d",
"7e8s",
"7e8t",
"7e93",
"7e94",
"7ea3",
"7u05",
"7u06"
] | 9 | [
"PUB00020479",
"PUB00055557",
"PUB00055565",
"PUB00056101",
"PUB00153720"
] | [
"9564032",
"11239471",
"18801063",
"17475775",
"35080977"
] | [
"TRAPP, a highly conserved novel complex on the cis-Golgi that mediates vesicle docking and fusion.",
"TRAPP I implicated in the specificity of tethering in ER-to-Golgi transport.",
"The TRAPP complex: insights into its architecture and function.",
"The role of Trs65 in the Ypt/Rab guanine nucleotide exchange... | [
1998,
2001,
2008,
2007,
2022
] | 5 | [] | [] | 0 | 0 | null | [
"Saccharomycetes"
] | [
60
] | 1 | [
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)"
] | [
1
] | 1 | true | Domain | Trafficking protein particle complex II-specific subunit 65, IgD2 | Trafficking protein particle complex II-specific subunit 65, IgD2 | IgD2_Trs65 | 4 |
IPR055427 | 55,427 | Trafficking protein particle complex subunit 13, N-terminal | TRAPPC13_N | Domain | 5,489 | false | false | This entry represents the N-terminal domain, which may adopt a β-sandwich fold with an insertion at the very N-terminal consisting of a short β-strand and α-helix connected by a long loop. Trafficking protein particle complex subunit 13 (TRAPPC13) is involved in regulating autophagy and survival in response to small mo... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF06159"
] | [
"TRAPPC13_N"
] | [
5489
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-8876198",
"R-CEL-8876198",
"R-DDI-8876198",
"R-DME-8876198",
"R-HSA-8876198",
"R-MMU-8876198",
"R-RNO-8876198"
] | [
"REACTOME:R-BTA-8876198",
"REACTOME:R-CEL-8876198",
"REACTOME:R-DDI-8876198",
"REACTOME:R-DME-8876198",
"REACTOME:R-HSA-8876198",
"REACTOME:R-MMU-8876198",
"REACTOME:R-RNO-8876198"
] | 7 | [] | 0 | [
"PUB00090991"
] | [
"28536105"
] | [
"TRAPPC13 modulates autophagy and the response to Golgi stress."
] | [
2017
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
5489
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
5,
1,
4,
1,
4,
2,
1,
2,
5,
6
] | 10 | true | Domain | Trafficking protein particle complex subunit 13, N-terminal | Trafficking protein particle complex subunit 13, N-terminal | TRAPPC13_N | 4 |
IPR055428 | 55,428 | Trafficking protein particle complex subunit 13, C-terminal | TRAPPC13_C | Domain | 3,270 | false | false | This entry represents the C-terminal domain of TRAPPC13 which is predicted to adopt an Ig-like fold. Trafficking protein particle complex subunit 13 (TRAPPC13) is involved in regulating autophagy and survival in response to small molecule compound-induced Golgi stress [ ]. It is the mammal homologue of Trs65 from yeast... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23643"
] | [
"TRAPPC13_C"
] | [
3270
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-8876198",
"R-CEL-8876198",
"R-DDI-8876198",
"R-DME-8876198",
"R-HSA-8876198",
"R-MMU-8876198",
"R-RNO-8876198"
] | [
"REACTOME:R-BTA-8876198",
"REACTOME:R-CEL-8876198",
"REACTOME:R-DDI-8876198",
"REACTOME:R-DME-8876198",
"REACTOME:R-HSA-8876198",
"REACTOME:R-MMU-8876198",
"REACTOME:R-RNO-8876198"
] | 7 | [] | 0 | [
"PUB00090991"
] | [
"28536105"
] | [
"TRAPPC13 modulates autophagy and the response to Golgi stress."
] | [
2017
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Pyrococcus horikoshii"
] | [
3268,
2
] | 2 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
5,
1,
4,
1,
3,
2,
5,
5,
4
] | 9 | true | Domain | Trafficking protein particle complex subunit 13, C-terminal | Trafficking protein particle complex subunit 13, C-terminal | TRAPPC13_C | 8 |
IPR055429 | 55,429 | Trafficking protein particle complex subunit 13, middle domain | TRAPPC13_M | Domain | 5,131 | false | false | This entry represents the middle domain of TRAPPC13 which is predicted to adopt a β-sandwich fold. Trafficking protein particle complex subunit 13 (TRAPPC13) is involved in regulating autophagy and survival in response to small molecule compound-induced Golgi stress [ ]. It is the mammal homologue of Trs65 from yeast, ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23647"
] | [
"TRAPPC13_M"
] | [
5131
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-8876198",
"R-CEL-8876198",
"R-DDI-8876198",
"R-DME-8876198",
"R-HSA-8876198",
"R-MMU-8876198",
"R-RNO-8876198"
] | [
"REACTOME:R-BTA-8876198",
"REACTOME:R-CEL-8876198",
"REACTOME:R-DDI-8876198",
"REACTOME:R-DME-8876198",
"REACTOME:R-HSA-8876198",
"REACTOME:R-MMU-8876198",
"REACTOME:R-RNO-8876198"
] | 7 | [] | 0 | [
"PUB00090991"
] | [
"28536105"
] | [
"TRAPPC13 modulates autophagy and the response to Golgi stress."
] | [
2017
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
5131
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
4,
1,
4,
1,
3,
2,
3,
4,
6
] | 9 | true | Domain | Trafficking protein particle complex subunit 13, middle domain | Trafficking protein particle complex subunit 13, middle domain | TRAPPC13_M | 7 |
IPR055430 | 55,430 | Pre-mRNA-splicing factor Syf1/CRNKL1-like, C-terminal HAT-repeats domain | HAT_Syf1_CNRKL1_C | Domain | 10,770 | false | false | This entry includes a group of pre-mRNA-processing factors that are components of the spliceosome that are involved in pre-RNA splicing, including Syf1 from human and its homologues from fungi, crooked neck from Drosophila and its homologues from human and fungi Crooked neck-like protein 1 (CRNKL1/SYF-3) and CFL1, resp... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23231"
] | [
"HAT_Syf1_CNRKL1_C"
] | [
10770
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-DDI-6781823",
"R-DDI-6782135",
"R-DDI-6782210",
"R-DDI-72163",
"R-DME-6781823",
"R-DME-6782135",
"R-DME-6782210",
"R-DME-6791226",
"R-DME-72163",
"R-HSA-6781823",
"R-HSA-6781827",
"R-HSA-6782135",
"R-HSA-6782210",
"R-HSA-72163",
"R-MMU-6781823",
"R-MMU-6782135",
"R-MMU-6782210",
... | [
"REACTOME:R-DDI-6781823",
"REACTOME:R-DDI-6782135",
"REACTOME:R-DDI-6782210",
"REACTOME:R-DDI-72163",
"REACTOME:R-DME-6781823",
"REACTOME:R-DME-6782135",
"REACTOME:R-DME-6782210",
"REACTOME:R-DME-6791226",
"REACTOME:R-DME-72163",
"REACTOME:R-HSA-6781823",
"REACTOME:R-HSA-6781827",
"REACTOME:R-... | 29 | [
"3jb9",
"5gm6",
"5gmk",
"5lj3",
"5lj5",
"5lqw",
"5mps",
"5mq0",
"5mqf",
"5wsg",
"5xjc",
"5y88",
"5ylz",
"5yzg",
"5z56",
"5z57",
"5z58",
"6bk8",
"6exn",
"6ff4",
"6ff7",
"6icz",
"6id0",
"6id1",
"6j6g",
"6j6h",
"6j6n",
"6j6q",
"6qdv",
"6zym",
"7a5p",
"7abi"... | 59 | [
"PUB00097019",
"PUB00152085",
"PUB00155642"
] | [
"28076346",
"27459055",
"35705093"
] | [
"Cryo-EM structure of a human spliceosome activated for step 2 of splicing.",
"Cryo-EM structure of the spliceosome immediately after branching.",
"Mechanism of exon ligation by human spliceosome."
] | [
2017,
2016,
2022
] | 3 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
17,
10751,
2
] | 3 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
23,
3,
2,
3,
7,
3,
2,
25,
12,
1,
2,
42
] | 12 | true | Domain | Pre-mRNA-splicing factor Syf1/CRNKL1-like, C-terminal HAT-repeats domain | Pre-mRNA-splicing factor Syf1/CRNKL1-like, C-terminal HAT-repeats domain | HAT_Syf1_CNRKL1_C | 8 |
IPR055431 | 55,431 | Anti-sigma factor RsgI-like, middle domain | RsgI_M | Domain | 2,373 | false | false | The heat shock genes in B. subtilis can be classified into several groups according to their regulation [ ], and the sigma gene, sigI, of Bacillus subtilis belongs to the group IV heat-shock response genes and has many orthologues in firmicutes [ , ]. Regulation of sigma factor I is carried out by RsgI from the same op... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23750"
] | [
"RsgI_M"
] | [
2373
] | 1 | [] | [] | [] | 0 | [
"8hdj",
"8hep",
"8heq",
"8her",
"8t9n",
"8u9o"
] | 6 | [
"PUB00034420",
"PUB00056050"
] | [
"11157964",
"17185538"
] | [
"Putative sigma factor SigI (YkoZ) of Bacillus subtilis is induced by heat shock.",
"Regulatory role of RsgI in sigI expression in Bacillus subtilis."
] | [
2001,
2007
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"metagenomes"
] | [
2355,
18
] | 2 | [] | [] | 0 | true | Domain | Anti-sigma factor RsgI-like, middle domain | Anti-sigma factor RsgI-like, middle domain | RsgI_M | 3 |
IPR055432 | 55,432 | STING, ligand-binding domain | STING_LBD | Domain | 1,666 | false | false | This entry represents the ligand-binding domain (LBD) of Transmembrane protein 173 which binds to c-di-GMP [ , ]. Cyclic dinucleotides induce a conformational change to the STING LBD, leading to high-order oligomerization of STING that is essential for triggering the downstream signalling pathways [ ]. Transmembrane pr... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF15009"
] | [
"STING_LBD"
] | [
1666
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-1834941",
"R-BTA-3134975",
"R-BTA-3249367",
"R-BTA-3270619",
"R-BTA-6798695",
"R-DME-1834941",
"R-DME-3134975",
"R-DME-3249367",
"R-DME-6798695",
"R-DRE-1834941",
"R-DRE-3134975",
"R-DRE-3249367",
"R-DRE-6798695",
"R-GGA-1834941",
"R-GGA-6798695",
"R-HSA-1834941",
"R-HSA-31349... | [
"REACTOME:R-BTA-1834941",
"REACTOME:R-BTA-3134975",
"REACTOME:R-BTA-3249367",
"REACTOME:R-BTA-3270619",
"REACTOME:R-BTA-6798695",
"REACTOME:R-DME-1834941",
"REACTOME:R-DME-3134975",
"REACTOME:R-DME-3249367",
"REACTOME:R-DME-6798695",
"REACTOME:R-DRE-1834941",
"REACTOME:R-DRE-3134975",
"REACTOM... | 35 | [
"4ef4",
"4ef5",
"4emt",
"4emu",
"4f5d",
"4f5e",
"4f5w",
"4f5y",
"4f9e",
"4f9g",
"4jc5",
"4kby",
"4kc0",
"4ksy",
"4loh",
"4loi",
"4loj",
"4lok",
"4lol",
"4qxo",
"4qxp",
"4qxq",
"4qxr",
"4yp1",
"5bqx",
"5cfl",
"5cfm",
"5cfn",
"5cfo",
"5cfp",
"5cfq",
"5cfr"... | 141 | [
"PUB00069826",
"PUB00069827",
"PUB00069828",
"PUB00069829",
"PUB00081854",
"PUB00155854"
] | [
"18724357",
"19776740",
"18818105",
"19433799",
"22728660",
"35388221"
] | [
"STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling.",
"STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity.",
"The adaptor protein MITA links virus-sensing receptors to IRF3 transcription factor activation.",
"ERIS, an endoplasmic reticulum... | [
2008,
2009,
2008,
2009,
2012,
2022
] | 6 | [] | [] | 0 | 0 | null | [
"Opisthokonta"
] | [
1666
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
2,
9,
5,
3
] | 5 | true | Domain | STING, ligand-binding domain | STING, ligand-binding domain | STING_LBD | 4 |
IPR055433 | 55,433 | Pre-mRNA-splicing factor Syf1-like, N-terminal HAT-repeats domain | HAT_Syf1-like_N | Domain | 8,486 | false | false | This entry includes a group of pre-mRNA-processing factors that are components of the spliceosome, involved in pre-RNA splicing, including Syf1 from human and its homologues from fungi, CFL1. These proteins contain HAT (Half A TPR) repeats which have a repetitive pattern characterised by three aromatic residues with a ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23233"
] | [
"HAT_Syf1_CNRKL1_N"
] | [
8486
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-DDI-6781823",
"R-DDI-6782135",
"R-DDI-6782210",
"R-DDI-72163",
"R-DME-6781823",
"R-DME-6782135",
"R-DME-6782210",
"R-DME-72163",
"R-HSA-6781823",
"R-HSA-6781827",
"R-HSA-6782135",
"R-HSA-6782210",
"R-HSA-72163",
"R-MMU-6781823",
"R-MMU-6782135",
"R-MMU-6782210",
"R-MMU-72163",
"... | [
"REACTOME:R-DDI-6781823",
"REACTOME:R-DDI-6782135",
"REACTOME:R-DDI-6782210",
"REACTOME:R-DDI-72163",
"REACTOME:R-DME-6781823",
"REACTOME:R-DME-6782135",
"REACTOME:R-DME-6782210",
"REACTOME:R-DME-72163",
"REACTOME:R-HSA-6781823",
"REACTOME:R-HSA-6781827",
"REACTOME:R-HSA-6782135",
"REACTOME:R-... | 28 | [
"3jb9",
"5gm6",
"5gmk",
"5ic8",
"5lj3",
"5lj5",
"5lqw",
"5mps",
"5mq0",
"5mqf",
"5nlg",
"5oql",
"5wsg",
"5wwm",
"5xjc",
"5y88",
"5ylz",
"5yzg",
"5z56",
"5z57",
"6bk8",
"6exn",
"6ff7",
"6icz",
"6id0",
"6id1",
"6j6g",
"6j6h",
"6j6n",
"6j6q",
"6qdv",
"6rxt"... | 64 | [
"PUB00097019",
"PUB00152085",
"PUB00155642"
] | [
"28076346",
"27459055",
"35705093"
] | [
"Cryo-EM structure of a human spliceosome activated for step 2 of splicing.",
"Cryo-EM structure of the spliceosome immediately after branching.",
"Mechanism of exon ligation by human spliceosome."
] | [
2017,
2016,
2022
] | 3 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
8486
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
25,
1,
1,
1,
2,
4,
2,
11,
6,
2,
2,
17
] | 12 | true | Domain | Pre-mRNA-splicing factor Syf1-like, N-terminal HAT-repeats domain | Pre-mRNA-splicing factor Syf1-like, N-terminal HAT-repeats domain | HAT_Syf1-like_N | 8 |
IPR055434 | 55,434 | STING, transmembrane domain | STING_TM | Domain | 1,116 | false | false | This entry represents the transmembrane domain (TM) of Transmembrane protein 173 which contains a cryptic pocket involved in inter-dimer interactions that mediate the formation of the high-order oligomer [ ]. Transmembrane protein 173, also known as stimulator of interferon genes protein (STING), is a transmembrane ada... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23417"
] | [
"STING_TM"
] | [
1116
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-1834941",
"R-BTA-3134975",
"R-BTA-3249367",
"R-BTA-3270619",
"R-BTA-6798695",
"R-DME-1834941",
"R-DME-3134975",
"R-DME-3249367",
"R-DME-6798695",
"R-DRE-1834941",
"R-DRE-3134975",
"R-DRE-3249367",
"R-DRE-6798695",
"R-GGA-1834941",
"R-GGA-6798695",
"R-HSA-1834941",
"R-HSA-31349... | [
"REACTOME:R-BTA-1834941",
"REACTOME:R-BTA-3134975",
"REACTOME:R-BTA-3249367",
"REACTOME:R-BTA-3270619",
"REACTOME:R-BTA-6798695",
"REACTOME:R-DME-1834941",
"REACTOME:R-DME-3134975",
"REACTOME:R-DME-3249367",
"REACTOME:R-DME-6798695",
"REACTOME:R-DRE-1834941",
"REACTOME:R-DRE-3134975",
"REACTOM... | 35 | [
"6nt5",
"6nt6",
"6nt7",
"6nt8",
"6nt9",
"7sii",
"8flk",
"8flm",
"8gsz",
"8gt6",
"8ik0",
"8ik3",
"8ywb",
"9ct3",
"9ct4",
"9ct5",
"9ct6",
"9jw6"
] | 18 | [
"PUB00081854",
"PUB00155854"
] | [
"22728660",
"35388221"
] | [
"Crystal structures of STING protein reveal basis for recognition of cyclic di-GMP.",
"Activation of STING by targeting a pocket in the transmembrane domain."
] | [
2012,
2022
] | 2 | [] | [] | 0 | 0 | null | [
"Opisthokonta"
] | [
1116
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
1,
8,
4,
3
] | 5 | true | Domain | STING, transmembrane domain | STING, transmembrane domain | STING_TM | 6 |
IPR055435 | 55,435 | TMEM131L, third Ig-like domain | Ig_TMEM131L_3 | Domain | 2,936 | false | false | This entry represents the third Ig-like domain of TMEM131L and the fourth in TMEM131. Transmembrane protein 131-like (TMEM131L) was identified as a negative regulator of thymocyte proliferation that acts through mixed Wnt-dependent and independent mechanisms. It has two isoforms, L and S, which have different subcellul... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24498"
] | [
"Ig_TMEM131L_3"
] | [
2936
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00090250",
"PUB00155677"
] | [
"23690469",
"32095531"
] | [
"Identification of TMEM131L as a novel regulator of thymocyte proliferation in humans.",
"Broadly conserved roles of TMEM131 family proteins in intracellular collagen assembly and secretory cargo trafficking."
] | [
2013,
2020
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
2936
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
7,
3,
4,
9
] | 4 | true | Domain | TMEM131L, third Ig-like domain | TMEM131L, third Ig-like domain | Ig_TMEM131L_3 | 3 |
IPR055437 | 55,437 | TMEM131L, fifth Ig-like domain | TMEM131L_Ig_5 | Domain | 4,111 | false | false | This entry represents the fifth Ig-like domain of TMEM131L which is eighth in TMEM131. Transmembrane protein 131-like (TMEM131L) was identified as a negative regulator of thymocyte proliferation that acts through mixed Wnt-dependent and independent mechanisms. It has two isoforms, L and S, which have different subcellu... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24501"
] | [
"Ig_TMEM131L_5"
] | [
4111
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00090250",
"PUB00155677"
] | [
"23690469",
"32095531"
] | [
"Identification of TMEM131L as a novel regulator of thymocyte proliferation in humans.",
"Broadly conserved roles of TMEM131 family proteins in intracellular collagen assembly and secretory cargo trafficking."
] | [
2013,
2020
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
4111
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
7,
1,
7,
1,
5,
3,
5,
10,
5
] | 9 | true | Domain | TMEM131L, fifth Ig-like domain | TMEM131L, fifth Ig-like domain | TMEM131L_Ig_5 | 4 |
IPR055438 | 55,438 | Succinylglutamate desuccinylase/Aspartoacylase, catalytic domain | AstE_AspA_cat | Domain | 24,789 | false | false | This entry represents the catalytic domain found in Succinylglutamate desuccinylase (AstE), aspartoacylase (AspA) and related enzymes. AstE catalyses the fifth and last step in arginine catabolism by the arginine succinyltransferase pathway whereas AspA cleaves acylaspartate into a fatty acid and aspartate. Mutations i... | [
"GO:0016788"
] | [
"hydrolase activity, acting on ester bonds"
] | [
"molecular_function"
] | 1 | [
"PFAM"
] | [
"PF24827"
] | [
"AstE_AspA_cat"
] | [
24789
] | 1 | [
"EC",
"EC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"3.5.1",
"3.5.1.96",
"R-DRE-5423646",
"R-DRE-8963693",
"R-HSA-5423646",
"R-HSA-8963693",
"R-MMU-5423646",
"R-MMU-8963693",
"R-RNO-5423646",
"R-RNO-8963693",
"R-XTR-5423646",
"R-XTR-8963693"
] | [
"EC:3.5.1",
"EC:3.5.1.96",
"REACTOME:R-DRE-5423646",
"REACTOME:R-DRE-8963693",
"REACTOME:R-HSA-5423646",
"REACTOME:R-HSA-8963693",
"REACTOME:R-MMU-5423646",
"REACTOME:R-MMU-8963693",
"REACTOME:R-RNO-5423646",
"REACTOME:R-RNO-8963693",
"REACTOME:R-XTR-5423646",
"REACTOME:R-XTR-8963693"
] | 12 | [
"1yw4",
"1yw6",
"2bco",
"2g9d",
"2gu2",
"2i3c",
"2o4h",
"2o53",
"2q4z",
"2q51",
"2qj8",
"2qvp",
"3b2y",
"3cdx",
"3fmc",
"3ieh",
"3lwu",
"3na6",
"3nfz",
"3nh4",
"3nh5",
"3nh8",
"4axv",
"4mri",
"4mxu",
"4nfr",
"4tnu",
"6twl",
"6twm",
"8ein",
"8eip"
] | 31 | [
"PUB00008718",
"PUB00065416"
] | [
"8252036",
"20921362"
] | [
"Cloning of the human aspartoacylase cDNA and a common missense mutation in Canavan disease.",
"Structures of aminoacylase 3 in complex with acetylated substrates."
] | [
1993,
2010
] | 2 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
1826,
20362,
2384,
3,
214
] | 5 | [
"Danio rerio",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
6,
1,
7,
8,
12
] | 5 | true | Domain | Succinylglutamate desuccinylase/Aspartoacylase, catalytic domain | Succinylglutamate desuccinylase/Aspartoacylase, catalytic domain | AstE_AspA_cat | 3 |
IPR055440 | 55,440 | WDR90, 4th beta-propeller domain | Beta-prop_WDR90_4th | Domain | 1,535 | false | false | This entry represents the fourth β-propeller domain found in WD repeat-containing protein 90 from mouse and human. WDR90 proteins constitute an evolutionary conserved central core microtubule triplet component that is essential for maintaining the inner centriolar scaffold components in centrioles [ ]. This entry also ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23342"
] | [
"WDR90_beta-prop_4th"
] | [
1535
] | 1 | [] | [] | [] | 0 | [
"6u42",
"6ve7",
"8glv"
] | 3 | [
"PUB00155545"
] | [
"32946374"
] | [
"WDR90 is a centriolar microtubule wall protein important for centriole architecture integrity."
] | [
2020
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"hydrothermal vent metagenome"
] | [
55,
1479,
1
] | 3 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
4,
3,
1
] | 4 | true | Domain | WDR90, 4th beta-propeller domain | WDR90, 4th beta-propeller domain | Beta-prop_WDR90_4th | 1 |
IPR055441 | 55,441 | WDR90/POC16, second beta-propeller domain | Beta-prop_WDR90_POC16_2nd | Domain | 1,081 | false | false | This entry represents the second β-propeller domain found in WD repeat-containing protein 90 (WDR90) from animals, and the homologue protein POC16 from Chlamydomonas reinhardtii. WDR90 is proposed to be localised in the centriole and required for ciliogenesis [ ]. The similarities between WDR90 and the flagellar inner ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23393"
] | [
"Beta-prop_WDR90_POC16_2nd"
] | [
1081
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00090986",
"PUB00155545"
] | [
"28781053",
"32946374"
] | [
"Identification of Chlamydomonas Central Core Centriolar Proteins Reveals a Role for Human WDR90 in Ciliogenesis.",
"WDR90 is a centriolar microtubule wall protein important for centriole architecture integrity."
] | [
2017,
2020
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1081
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
3,
2,
1
] | 4 | true | Domain | WDR90/POC16, second beta-propeller domain | WDR90/POC16, second beta-propeller domain | Beta-prop_WDR90_POC16_2nd | 6 |
IPR055443 | 55,443 | Proteasome adapter and scaffold protein ECM29, HEAT-repeat domain | HEAT_ECM29 | Domain | 4,537 | false | false | This entry represents a HEAT-repeat domain found in ECM29, an adapter/scaffolding protein that binds to the 26S proteasome, motor proteins and other compartment specific proteins [ ]. This domain is found in the C-terminal half of ECM29, which binds kinesin and myosin [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24492"
] | [
"HEAT_ECM29"
] | [
4537
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00061901"
] | [
"20682791"
] | [
"A protein interaction network for Ecm29 links the 26 S proteasome to molecular motors and endosomal components."
] | [
2010
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
4537
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
8,
1,
2,
1,
3,
2,
1,
6,
7,
1,
1,
21
] | 12 | true | Domain | Proteasome adapter and scaffold protein ECM29, HEAT-repeat domain | Proteasome adapter and scaffold protein ECM29, HEAT-repeat domain | HEAT_ECM29 | 3 |
IPR055444 | 55,444 | ECM29, ARM-like repeats domain | ARM_ECM29 | Domain | 2,691 | false | false | This is a region of armadillo-like repeats found in human Proteasome adapter and scaffold protein ECM29 and similar protein sequences found in animals and some uncharacterised plant and fungal proteins. ECM29 binds to the 26S proteasome, motor proteins and other compartment specific proteins. This entry is often found ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23702"
] | [
"ARM_ECM29"
] | [
2691
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
2691
] | 1 | [
"Arabidopsis thaliana",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
8,
2,
1,
5,
3,
3,
9,
19
] | 8 | true | Domain | ECM29, ARM-like repeats domain | ECM29, ARM-like repeats domain | ARM_ECM29 | 8 |
IPR055446 | 55,446 | ATP-dependent RecD2 DNA helicase, OB-fold domain | RecD2_N_OB | Domain | 8,440 | false | false | This entry represents a domain which is found N-terminal in ATP-dependent RecD2 DNA helicase (also known as YrrC) and related bacterial proteins. RecD2 may favour replication restart by preventing RecA from binding to blocked replication forks, avoiding unnecessary recombination during replication restart. It fuctions ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23139"
] | [
"OB_YrrC"
] | [
8440
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00153408",
"PUB00155985"
] | [
"35234892",
"24443534"
] | [
"The RecD2 helicase balances RecA activities.",
"RecD2 helicase limits replication fork stress in Bacillus subtilis."
] | [
2022,
2014
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Viruses",
"metagenomes"
] | [
8304,
55,
4,
77
] | 4 | [] | [] | 0 | true | Domain | ATP-dependent RecD2 DNA helicase, OB-fold domain | ATP-dependent RecD2 DNA helicase, OB-fold domain | RecD2_N_OB | 8 |
IPR055447 | 55,447 | Spike glycoprotein G, central domain, rhabdovirus | Rhabdo_glycop_CD | Domain | 6,188 | false | false | This entry represents the central domain (CD) which consists of domains I (β-sheet rich) and II (α-helical) [ ]). The glycoprotein G from rhabdoviruses, such as rabies virus (RABV), Mokola virus (MOKV) and European bat lyssavirus 1 (EBLV) [ , , , , , ] attaches the virus to host cellular receptor, and induces endocytos... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24833"
] | [
"Rhabdo_glycop_CD"
] | [
6188
] | 1 | [] | [] | [] | 0 | [
"4d6w",
"5i2m",
"5i2s",
"5mdm",
"5oy9",
"5oyl",
"6lgw",
"6lgx",
"6tit",
"6tmr",
"7u9g",
"8a1e",
"8zhw",
"8zhz",
"9hgn",
"9hh9",
"9hhr",
"9i8q",
"9kef",
"9kfb"
] | 20 | [
"PUB00003167",
"PUB00005582",
"PUB00155794",
"PUB00155795",
"PUB00155796",
"PUB00155797"
] | [
"9000093",
"1660200",
"35714192",
"32150590",
"35985336",
"28188244"
] | [
"Low pH-induced pore formation by spike proteins of enveloped viruses.",
"Membrane fusion activity, oligomerization, and assembly of the rabies virus glycoprotein.",
"Structure of the rabies virus glycoprotein trimer bound to a prefusion-specific neutralizing antibody.",
"Crystal structure of Mokola virus gly... | [
1996,
1991,
2022,
2020,
2022,
2017
] | 6 | [] | [] | 0 | 0 | null | [
"Gammaproteobacteria",
"Pancrustacea",
"Riboviria"
] | [
2,
5,
6181
] | 3 | [] | [] | 0 | true | Domain | Spike glycoprotein G, central domain, rhabdovirus | Spike glycoprotein G, central domain, rhabdovirus | Rhabdo_glycop_CD | 5 |
IPR055448 | 55,448 | Glycoprotein G, PH domain, rhabdovirus | PH_Rhabdo_glycop | Domain | 4,167 | false | false | This entry represents the PH domain (also known as the neck domain) [ ]. The glycoprotein G from rhabdoviruses, such as rabies virus (RABV), Mokola virus (MOKV) and European bat lyssavirus 1 (EBLV) [ , , , , , ] attaches the virus to host cellular receptor, and induces endocytosis of the virion. It forms the glycoprote... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24834"
] | [
"PH_Rhabdo_glycop"
] | [
4167
] | 1 | [] | [] | [] | 0 | [
"6lgw",
"6lgx",
"6tmr",
"6tou",
"7u9g",
"8a1e",
"8r40",
"8zhw",
"8zhz",
"9kef",
"9kep",
"9kfb"
] | 12 | [
"PUB00003167",
"PUB00005582",
"PUB00155794",
"PUB00155795",
"PUB00155796",
"PUB00155797"
] | [
"9000093",
"1660200",
"35714192",
"32150590",
"35985336",
"28188244"
] | [
"Low pH-induced pore formation by spike proteins of enveloped viruses.",
"Membrane fusion activity, oligomerization, and assembly of the rabies virus glycoprotein.",
"Structure of the rabies virus glycoprotein trimer bound to a prefusion-specific neutralizing antibody.",
"Crystal structure of Mokola virus gly... | [
1996,
1991,
2022,
2020,
2022,
2017
] | 6 | [] | [] | 0 | 0 | null | [
"Riboviria"
] | [
4167
] | 1 | [] | [] | 0 | true | Domain | Glycoprotein G, PH domain, rhabdovirus | Glycoprotein G, PH domain, rhabdovirus | PH_Rhabdo_glycop | 1 |
IPR055449 | 55,449 | INO80 complex subunit 3-like, middle region | Iec3-like_M | Domain | 1,016 | false | false | This entry represents the middle region of a group of fungal sequences that are homologues of the INO80 complex subunit 3 (Iec3) from S.pombe. They differ in this region that is absent on the S.pombe homologue which only consists of an α-helix. According to structure predictions, this section may adopt an arrangement o... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24244"
] | [
"Iec3-like_M"
] | [
1016
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1016
] | 1 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)"
] | [
1
] | 1 | true | Domain | INO80 complex subunit 3-like, middle region | INO80 complex subunit 3-like, middle region | Iec3-like_M | 5 |
IPR055450 | 55,450 | AP-5 complex subunit zeta-1, ARM repeats domain | AP5Z1_ARM | Domain | 1,988 | false | false | This entry represents a region of ARM-repeats in human AP-5 complex subunit zeta-1. Adaptor protein (AP) complexes facilitate the trafficking of cargo from one membrane compartment of the cell to another by recruiting other proteins to particular types of vesicles. AP-5 is involved in trafficking proteins from endosome... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF14764"
] | [
"SPG48"
] | [
1988
] | 1 | [] | [] | [] | 0 | [
"8yab",
"8yah"
] | 2 | [
"PUB00067709",
"PUB00067710",
"PUB00067711"
] | [
"22022230",
"20613862",
"22022232"
] | [
"The fifth adaptor protein complex.",
"A genome-scale DNA repair RNAi screen identifies SPG48 as a novel gene associated with hereditary spastic paraplegia.",
"And now there are five: a new player in intracellular trafficking pathways."
] | [
2011,
2010,
2011
] | 3 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1988
] | 1 | [
"Arabidopsis thaliana",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
6,
2,
5,
5,
5,
3,
12
] | 7 | true | Domain | AP-5 complex subunit zeta-1, ARM repeats domain | AP-5 complex subunit zeta-1, ARM repeats domain | AP5Z1_ARM | 2 |
IPR055451 | 55,451 | CATSPERD, Ig-like domain | Ig-like_CATSPERD | Domain | 339 | false | false | This entry represents a Ig-like domain found in the central region of the delta subunit (CATSPERD) [ ]. The CATSPER (cation channel of sperm) complex is a tetrameric complex consisting of CATSPER1, CATSPER2, CATSPER3 and CATSPER4, it functions as an alkalinisation-activated calcium channel. This complex is involved in ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23747"
] | [
"Ig-like_CATSPERD"
] | [
339
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-1300642",
"R-MMU-1300642",
"R-RNO-1300642"
] | [
"REACTOME:R-HSA-1300642",
"REACTOME:R-MMU-1300642",
"REACTOME:R-RNO-1300642"
] | 3 | [
"7eeb"
] | 1 | [
"PUB00067741",
"PUB00100197"
] | [
"21224844",
"34225353"
] | [
"A novel gene required for male fertility and functional CATSPER channel formation in spermatozoa.",
"Structure of a mammalian sperm cation channel complex."
] | [
2011,
2021
] | 2 | [] | [] | 0 | 0 | null | [
"Deuterostomia"
] | [
339
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
2,
5
] | 3 | true | Domain | CATSPERD, Ig-like domain | CATSPERD, Ig-like domain | Ig-like_CATSPERD | 6 |
IPR055452 | 55,452 | TRAPP14, C-terminal | TRAPP14_C | Domain | 757 | false | false | This entry includes Trafficking protein particle complex subunit 14 (TRAPP14), which is a specific subunit of the TRAPP (transport protein particle) II complex, a conserved vesicle tethering complex that functions in late Golgi trafficking as a membrane tether [ , ]. This entry represents the C-terminal domain which is... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23652"
] | [
"TRAPP14_C"
] | [
757
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00092767",
"PUB00096661"
] | [
"30715179",
"31467083"
] | [
"Mutations in the microtubule-associated protein MAP11 (C7orf43) cause microcephaly in humans and zebrafish.",
"The C7orf43/TRAPPC14 component links the TRAPPII complex to Rabin8 for preciliary vesicle tethering at the mother centriole during ciliogenesis."
] | [
2019,
2019
] | 2 | [] | [] | 0 | 0 | null | [
"Eumetazoa"
] | [
757
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
4,
3,
3
] | 4 | true | Domain | TRAPP14, C-terminal | TRAPP14, C-terminal | TRAPP14_C | 5 |
IPR055453 | 55,453 | TRAPP14, N-terminal | TRAPP14_N | Domain | 784 | false | false | This entry includes Trafficking protein particle complex subunit 14 (TRAPP14), a specific subunit of the TRAPP (transport protein particle) II complex, a conserved vesicle tethering complex that functions in late Golgi trafficking as a membrane tether [ , ]. This entry represents the N-terminal region consisting of two... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF15806"
] | [
"TRAPP14_N"
] | [
784
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00092767",
"PUB00096661"
] | [
"30715179",
"31467083"
] | [
"Mutations in the microtubule-associated protein MAP11 (C7orf43) cause microcephaly in humans and zebrafish.",
"The C7orf43/TRAPPC14 component links the TRAPPII complex to Rabin8 for preciliary vesicle tethering at the mother centriole during ciliogenesis."
] | [
2019,
2019
] | 2 | [] | [] | 0 | 0 | null | [
"Eumetazoa",
"bird metagenome"
] | [
783,
1
] | 2 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
6,
3,
4
] | 4 | true | Domain | TRAPP14, N-terminal | TRAPP14, N-terminal | TRAPP14_N | 7 |
IPR055454 | 55,454 | CCR4-NOT transcription complex subunit 1-like, NOT1 connector | CNOT1-like_NOT1_connector | Domain | 5,362 | false | false | This entry represents a region of human CCR4-NOT transcription complex subunit 1 (CNOT1), an scaffolding component of the CCR4-NOT complex, which is one of the major cellular mRNA deadenylases. This region shows several repeats of the HEAT type [ , ]. Members of this group are predominantly found in animals and fungal ... | [] | [] | [] | 0 | [
"PFAM",
"PFAM"
] | [
"PF23590",
"PF25097"
] | [
"NOT1_connector",
"ARM_Cnot1"
] | [
2165,
3199
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-DRE-6804115",
"R-HSA-429947",
"R-HSA-6804115",
"R-HSA-9820841",
"R-MMU-429947",
"R-MMU-6804115",
"R-XTR-429947",
"R-XTR-6804115"
] | [
"REACTOME:R-DRE-6804115",
"REACTOME:R-HSA-429947",
"REACTOME:R-HSA-6804115",
"REACTOME:R-HSA-9820841",
"REACTOME:R-MMU-429947",
"REACTOME:R-MMU-6804115",
"REACTOME:R-XTR-429947",
"REACTOME:R-XTR-6804115"
] | 8 | [
"4c0d",
"6h3z"
] | 2 | [
"PUB00088315",
"PUB00153875"
] | [
"24121232",
"36586408"
] | [
"Structure and assembly of the NOT module of the human CCR4-NOT complex.",
"The human CNOT1-CNOT10-CNOT11 complex forms a structural platform for protein-protein interactions."
] | [
2013,
2023
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
5362
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)",
"Zea ma... | [
10,
1,
1,
8,
3,
5,
6,
5,
1,
1,
105
] | 11 | true | Domain | CCR4-NOT transcription complex subunit 1-like, NOT1 connector | CCR4-NOT transcription complex subunit 1-like, NOT1 connector | CNOT1-like_NOT1_connector | 7 |
IPR055455 | 55,455 | Proteasome activator complex subunit 4-like, HEAT repeat-like | HEAT_PSME4 | Domain | 4,877 | false | false | This domain is found in Proteasome activator complex subunit 4 (PSME4) and in similar sequences from animals and fungi as well as some uncharacterised proteins from plants. PSME4 is an associated component of the proteasome that specifically recognises acetylated histones and promotes ATP- and ubiquitin -independent de... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23096"
] | [
"HEAT_PSME4"
] | [
4877
] | 1 | [
"REACTOME"
] | [
"R-HSA-9907900"
] | [
"REACTOME:R-HSA-9907900"
] | 1 | [
"4v7o",
"6kwx",
"6kwy",
"6rey",
"7naq",
"8cvs",
"9d0t",
"9d4c",
"9gbk"
] | 9 | [
"PUB00076285",
"PUB00155659",
"PUB00156026"
] | [
"20227375",
"32134919",
"39260885"
] | [
"Structure of a Blm10 complex reveals common mechanisms for proteasome binding and gate opening.",
"Cryo-EM structures of the human PA200 and PA200-20S complex reveal regulation of proteasome gate opening and two PA200 apertures.",
"Structural roles of Ump1 and β-subunit propeptides in proteasome biogenesis."
] | [
2010,
2020,
2024
] | 3 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Brachyspigtaviriform stantoni",
"Eukaryota"
] | [
20,
1,
4856
] | 3 | [
"Caenorhabditis elegans",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Zea mays"
] | [
5,
7,
1,
1,
1,
3,
7,
1,
1
] | 9 | true | Domain | Proteasome activator complex subunit 4-like, HEAT repeat-like | Proteasome activator complex subunit 4-like, HEAT repeat-like | HEAT_PSME4 | 1 |
IPR055457 | 55,457 | OST48, N-terminal domain | OST48_N | Domain | 5,792 | false | false | This is the N-terminal domain of OST48 subunits from animals and plants and the orthologue from yeast Wbp1. This domain is distantly related to the IFT52 N-terminal domain ( ). Members of this entry are involved in asparagine-linked protein glycosylation. In particular, dolichyl-diphosphooligosaccharide-protein glycosy... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF03345"
] | [
"OST48_N"
] | [
5792
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-CEL-6798695",
"R-DDI-6798695",
"R-DME-6798695",
"R-DME-9768727",
"R-DRE-6798695",
"R-DRE-9768727",
"R-HSA-1799339",
"R-HSA-446203",
"R-HSA-6798695",
"R-HSA-879415",
"R-HSA-9694548",
"R-HSA-9768727",
"R-MMU-6798695",
"R-MMU-9768727",
"R-RNO-6798695",
"R-RNO-9768727",
"R-SCE-6798695... | [
"REACTOME:R-CEL-6798695",
"REACTOME:R-DDI-6798695",
"REACTOME:R-DME-6798695",
"REACTOME:R-DME-9768727",
"REACTOME:R-DRE-6798695",
"REACTOME:R-DRE-9768727",
"REACTOME:R-HSA-1799339",
"REACTOME:R-HSA-446203",
"REACTOME:R-HSA-6798695",
"REACTOME:R-HSA-879415",
"REACTOME:R-HSA-9694548",
"REACTOME:... | 19 | [
"6c26",
"6ezn",
"6s7o",
"6s7t",
"7oci",
"8agb",
"8agc",
"8age",
"8b6l",
"8pn9"
] | 10 | [
"PUB00019399",
"PUB00076363",
"PUB00155776"
] | [
"9367678",
"25135935",
"31831667"
] | [
"Genome organization of human 48-kDa oligosaccharyltransferase (DDOST).",
"Oxidoreductase activity is necessary for N-glycosylation of cysteine-proximal acceptor sites in glycoproteins.",
"Cryo-electron microscopy structures of human oligosaccharyltransferase complexes OST-A and OST-B."
] | [
1997,
2014,
2019
] | 3 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Haloarcula",
"Novosphingobium aureum"
] | [
5787,
4,
1
] | 3 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
3,
1,
2,
1,
3,
3,
1,
2,
5,
1,
1,
13
] | 12 | true | Domain | OST48, N-terminal domain | OST48, N-terminal domain | OST48_N | 4 |
IPR055458 | 55,458 | IFT52, GIFT domain | IFT52_GIFT | Domain | 2,497 | false | false | This domain is found in various eukaryotic and prokaryotic intra-flagellar transport proteins involved in gliding motility, as well as in several hypothetical proteins. Intraflagellar transport protein 52 homolog (IFT52) from human is included in this entry, which is essential for anterograde complex integrity and for ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23355"
] | [
"IFT52_GIFT"
] | [
2497
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-5610787",
"R-HSA-5620924",
"R-MMU-5610787",
"R-MMU-5620924"
] | [
"REACTOME:R-HSA-5610787",
"REACTOME:R-HSA-5620924",
"REACTOME:R-MMU-5610787",
"REACTOME:R-MMU-5620924"
] | 4 | [
"5fmr",
"5fms",
"8bd7",
"8ruy"
] | 4 | [
"PUB00090376",
"PUB00151717"
] | [
"27466190",
"25349261"
] | [
"IFT52 mutations destabilize anterograde complex assembly, disrupt ciliogenesis and result in short rib polydactyly syndrome.",
"Crystal structures of IFT70/52 and IFT52/46 provide insight into intraflagellar transport B core complex assembly."
] | [
2016,
2014
] | 2 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"marine sediment metagenome"
] | [
37,
102,
2329,
29
] | 4 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
4,
1,
2,
3,
5
] | 6 | true | Domain | IFT52, GIFT domain | IFT52, GIFT domain | IFT52_GIFT | 8 |
IPR055459 | 55,459 | OST48, middle domain | OST48_MD | Domain | 4,879 | false | false | This entry represents the middle domain (MD) of OST48 from animals and its orthologue from yeast Wbp1 [ , ]. This domain adopts a β-sandwich fold, which together with the N-terminal domain ( ), interacts with riphophorin II/Swp1 subunit [ ]. Members of this entry are involved in asparagine-linked protein glycosylation.... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23358"
] | [
"OST48_MD"
] | [
4879
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-CEL-6798695",
"R-DDI-6798695",
"R-DME-6798695",
"R-DME-9768727",
"R-DRE-6798695",
"R-DRE-9768727",
"R-HSA-1799339",
"R-HSA-446203",
"R-HSA-6798695",
"R-HSA-879415",
"R-HSA-9694548",
"R-HSA-9768727",
"R-MMU-6798695",
"R-MMU-9768727",
"R-RNO-6798695",
"R-RNO-9768727",
"R-SCE-6798695... | [
"REACTOME:R-CEL-6798695",
"REACTOME:R-DDI-6798695",
"REACTOME:R-DME-6798695",
"REACTOME:R-DME-9768727",
"REACTOME:R-DRE-6798695",
"REACTOME:R-DRE-9768727",
"REACTOME:R-HSA-1799339",
"REACTOME:R-HSA-446203",
"REACTOME:R-HSA-6798695",
"REACTOME:R-HSA-879415",
"REACTOME:R-HSA-9694548",
"REACTOME:... | 19 | [
"6c26",
"6ezn",
"6s7o",
"6s7t",
"7oci",
"8agb",
"8agc",
"8age",
"8b6l",
"8pn9"
] | 10 | [
"PUB00019399",
"PUB00076363",
"PUB00155776",
"PUB00155777"
] | [
"9367678",
"25135935",
"31831667",
"29466327"
] | [
"Genome organization of human 48-kDa oligosaccharyltransferase (DDOST).",
"Oxidoreductase activity is necessary for N-glycosylation of cysteine-proximal acceptor sites in glycoproteins.",
"Cryo-electron microscopy structures of human oligosaccharyltransferase complexes OST-A and OST-B.",
"The atomic structure... | [
1997,
2014,
2019,
2018
] | 4 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
4879
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
3,
1,
2,
1,
2,
3,
1,
2,
4,
1,
1,
12
] | 12 | true | Domain | OST48, middle domain | OST48, middle domain | OST48_MD | 4 |
IPR055462 | 55,462 | Domain of unknown function DUF7034 | DUF7034 | Domain | 497 | false | false | This domain is found in a group of uncharacterised proteins from Dictyostelia. It is predicted to adopt Ig-like fold with the fibronectin type III-like topology. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23033"
] | [
"DUF7034"
] | [
497
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Dictyostelia",
"freshwater metagenome"
] | [
2,
492,
3
] | 3 | [] | [] | 0 | true | Domain | Domain of unknown function DUF7034 | Domain of unknown function DUF7034 | DUF7034 | 8 |
IPR055463 | 55,463 | Domain of unknown function DUF7035 | DUF7035 | Domain | 511 | false | false | This domain is found in a group of uncharacterised proteins from Dictyostelia. It is predicted to adopt Ig-like fold with the fibronectin type III-like topology. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23034"
] | [
"DUF7035"
] | [
511
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Candidatus Methanocrinis alkalitolerans",
"Dictyostelia",
"ecological metagenomes"
] | [
12,
1,
495,
3
] | 4 | [] | [] | 0 | true | Domain | Domain of unknown function DUF7035 | Domain of unknown function DUF7035 | DUF7035 | 2 |
IPR055464 | 55,464 | Domain of unknown function DUF7036 | DUF7036 | Domain | 1,711 | false | false | This entry represents a predicted ferredoxin-like domain found in a family of uncharacterised plant proteins. This group of proteins typically has this domain duplicated. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23041"
] | [
"DUF7036"
] | [
1711
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Tracheophyta"
] | [
1711
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
19,
11,
14
] | 3 | true | Domain | Domain of unknown function DUF7036 | Domain of unknown function DUF7036 | DUF7036 | 4 |
IPR055467 | 55,467 | Domain of unknown function DUF7039 | DUF7039 | Domain | 82 | false | false | This entry represents a domain found in a family of uncharacterised proteins in nematodes. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23049"
] | [
"DUF7039"
] | [
82
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Caenorhabditis"
] | [
82
] | 1 | [
"Caenorhabditis elegans"
] | [
1
] | 1 | true | Domain | Domain of unknown function DUF7039 | Domain of unknown function DUF7039 | DUF7039 | 4 |
IPR055468 | 55,468 | Domain of unknown function DUF7040 | DUF7040 | Domain | 129 | false | false | This entry represents a C-terminal domain found in a family of uncharacterised proteins in nematodes. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23051"
] | [
"DUF7040"
] | [
129
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Caenorhabditis"
] | [
129
] | 1 | [
"Caenorhabditis elegans"
] | [
1
] | 1 | true | Domain | Domain of unknown function DUF7040 | Domain of unknown function DUF7040 | DUF7040 | 2 |
IPR055469 | 55,469 | Domain of unknown function DUF7041 | DUF7041 | Domain | 7,096 | false | false | This is a domain of unknown function predominantly found at the N-terminal of sequences from ticks, spiders and similar sequences from arthropods. According to structure predictions this domain may adopt an α-helical bundle fold similar to Ty3 transposon capsid-like proteins. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23055"
] | [
"DUF7041"
] | [
7096
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Armadillidium vulgare clopovirus",
"Bacteria",
"Metazoa"
] | [
1,
11,
7084
] | 3 | [] | [] | 0 | true | Domain | Domain of unknown function DUF7041 | Domain of unknown function DUF7041 | DUF7041 | 4 |
IPR055470 | 55,470 | Domain of unknown function DUF7042 | DUF7042 | Domain | 2,488 | false | false | This domain is found in a group of uncharacterised metazoan proteins. It is predicted to adopt a globular structure with lipocalin fold. It also contains several highly conserved cysteine residues that are likely involved in the formation of intra-domain disulfide bridges. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23069"
] | [
"DUF7042"
] | [
2488
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bilateria"
] | [
2488
] | 1 | [
"Caenorhabditis elegans",
"Drosophila melanogaster"
] | [
2,
5
] | 2 | true | Domain | Domain of unknown function DUF7042 | Domain of unknown function DUF7042 | DUF7042 | 6 |
IPR055471 | 55,471 | Domain of unknown function DUF7043 | DUF7043 | Domain | 2,035 | false | false | This domain is found in a group of uncharacterised metazoan proteins. It is predicted to adopt a globular structure with lipocalin fold. It also contains several highly conserved cysteine residues that are likely involved in the formation of intra-domain disulfide bridges. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23070"
] | [
"DUF7043"
] | [
2035
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eumetazoa"
] | [
2035
] | 1 | [
"Caenorhabditis elegans",
"Drosophila melanogaster"
] | [
2,
5
] | 2 | true | Domain | Domain of unknown function DUF7043 | Domain of unknown function DUF7043 | DUF7043 | 7 |
IPR055472 | 55,472 | Domain of unknown function DUF7044 | DUF7044 | Domain | 1,835 | false | false | This domain is found in a group of uncharacterised metazoan proteins. It is predicted to adopt a globular structure with lipocalin fold. It also contains several highly conserved cysteine residues that are likely involved in the formation of intra-domain disulfide bridges. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23071"
] | [
"DUF7044"
] | [
1835
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Protostomia"
] | [
1835
] | 1 | [
"Caenorhabditis elegans",
"Drosophila melanogaster"
] | [
2,
5
] | 2 | true | Domain | Domain of unknown function DUF7044 | Domain of unknown function DUF7044 | DUF7044 | 3 |
IPR055473 | 55,473 | Domain of unknown function DUF7045 | DUF7045 | Domain | 437 | false | false | This domain is found in a group of uncharacterised metazoan proteins. It is predicted to adopt a globular structure with lipocalin fold. It also contains several highly conserved cysteine residues that are likely involved in the formation of intra-domain disulfide bridges. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23073"
] | [
"DUF7045"
] | [
437
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Protostomia"
] | [
437
] | 1 | [
"Caenorhabditis elegans"
] | [
1
] | 1 | true | Domain | Domain of unknown function DUF7045 | Domain of unknown function DUF7045 | DUF7045 | 2 |
IPR055474 | 55,474 | Domain of unknown function DUF7046 | DUF7046 | Domain | 2,149 | false | false | This domain is found in a group of uncharacterised plant proteins. These proteins are probably distantly related to the plant-specific actin-binding protein SCAB1 and are predicted to contain a fusion domain composed of Ig and PH-like domains in a similar arrangement as in SCAB1 [ ]. The domain represented by this entr... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23080"
] | [
"DUF7046"
] | [
2149
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00076164"
] | [
"22356912"
] | [
"Plant actin-binding protein SCAB1 is dimeric actin cross-linker with atypical pleckstrin homology domain."
] | [
2012
] | 1 | [] | [] | 0 | 0 | null | [
"Embryophyta"
] | [
2149
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
29,
13,
39
] | 3 | true | Domain | Domain of unknown function DUF7046 | Domain of unknown function DUF7046 | DUF7046 | 2 |
IPR055475 | 55,475 | Domain of unknown function DUF7047 | DUF7047 | Domain | 509 | false | false | This is a domain of unknown function mostly found in arthropods. This domain may adopt a three helical bundle fold. These sequences might be related to reverse transcriptase polymerases. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23088"
] | [
"DUF7047"
] | [
509
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
509
] | 1 | [] | [] | 0 | true | Domain | Domain of unknown function DUF7047 | Domain of unknown function DUF7047 | DUF7047 | 1 |
IPR055476 | 55,476 | Domain of unknown function DUF7048 | DUF7048 | Domain | 29 | false | false | This entry represents a domain found in uncharacterised proteins mainly from Trypanosoma sp. According to structural predictions, this domain is likely to adopt a β-propeller fold. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23126"
] | [
"DUF7048"
] | [
29
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Trypanosomatidae"
] | [
29
] | 1 | [] | [] | 0 | true | Domain | Domain of unknown function DUF7048 | Domain of unknown function DUF7048 | DUF7048 | 1 |
IPR055477 | 55,477 | Domain of unknown function DUF7049 | DUF7049 | Domain | 1,052 | false | false | This domain is found in a group of uncharacterised proteins mainly from plants. This domain is predicted to fold into a globular structure that adopts a ferredoxin-like fold. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23132"
] | [
"DUF7049"
] | [
1052
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Magnoliopsida"
] | [
1052
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
6,
13,
16
] | 3 | true | Domain | Domain of unknown function DUF7049 | Domain of unknown function DUF7049 | DUF7049 | 3 |
IPR055478 | 55,478 | Domain of unknown function DUF7050 | DUF7050 | Domain | 783 | false | false | This domain is found N-terminal in a group of uncharacterised proteins mainly from plants. It shares a significant sequence similarity with the N-terminal domain of bHLH-MYC and R2R3-MYB transcription factors (Pfam:PF14215) and it is predicted to adopt similar structure. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23133"
] | [
"DUF7050"
] | [
783
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Embryophyta"
] | [
783
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
6,
8,
3
] | 3 | true | Domain | Domain of unknown function DUF7050 | Domain of unknown function DUF7050 | DUF7050 | 5 |
IPR055479 | 55,479 | Domain of unknown function DUF7051 | DUF7051 | Domain | 25 | false | false | This is a domain of unknown function mostly found in organisms within the Trypanosoma genus. This domain adopt a multiple helical bundle fold. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23136"
] | [
"DUF7051"
] | [
25
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Metakinetoplastina"
] | [
25
] | 1 | [] | [] | 0 | true | Domain | Domain of unknown function DUF7051 | Domain of unknown function DUF7051 | DUF7051 | 3 |
IPR055480 | 55,480 | NAD-dependent glutamate dehydrogenase, N-terminal domain | NAD-GDH_N | Domain | 2,100 | false | false | This domain is found in yeast NAD-specific glutamate dehydrogenase (GDH2, also known as DHE2) [ , ] and similar fungal proteins. GDH2 is involved in the degradation of glutamate to ammonia and alpha-ketoglutarate. This domain is found at the N terminus of GDH2 [ , ] and is predicted to adopt a globular structure compos... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23147"
] | [
"GDH2_N"
] | [
2100
] | 1 | [
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC"
] | [
"1.4.1.2",
"PWY-5022",
"PWY-6728",
"PWY-7126",
"PWY-8190"
] | [
"EC:1.4.1.2",
"METACYC:PWY-5022",
"METACYC:PWY-6728",
"METACYC:PWY-7126",
"METACYC:PWY-8190"
] | 5 | [] | 0 | [
"PUB00016745",
"PUB00042874"
] | [
"7901008",
"8398079"
] | [
"The role of the NAD-dependent glutamate dehydrogenase in restoring growth on glucose of a Saccharomyces cerevisiae phosphoglucose isomerase mutant.",
"NAD(+)-specific glutamate dehydrogenase of Neurospora crassa: cloning, complete nucleotide sequence, and gene mapping."
] | [
1993,
1993
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria candidate phyla",
"Eukaryota",
"marine sediment metagenome"
] | [
2,
2097,
1
] | 3 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
1,
1,
1
] | 3 | true | Domain | NAD-dependent glutamate dehydrogenase, N-terminal domain | NAD-dependent glutamate dehydrogenase, N-terminal domain | NAD-GDH_N | 6 |
IPR055481 | 55,481 | Domain of unknown function DUF7053 | DUF7053 | Domain | 3,358 | false | false | This domain is found in a group of uncharacterised proteins mainly from Fungi. It shares significant sequence similarity with domains members of the Bet v1-like superfamily and it is predicted to adopt similar structure. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23155"
] | [
"DUF7053"
] | [
3358
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Mycobacterium"
] | [
3355,
3
] | 2 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)"
] | [
3
] | 1 | true | Domain | Domain of unknown function DUF7053 | Domain of unknown function DUF7053 | DUF7053 | 6 |
IPR055482 | 55,482 | Domain of unknown function DUF7054 | DUF7054 | Domain | 3,382 | false | false | This domain is found in the uncharacterised protein At4g22758 from Arabidopsis thaliana and related proteins. It shares significant sequence similarity with CRIM domain and it is predicted to adopt a similar structure with ubiquitin-like topology. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23156"
] | [
"DUF7054"
] | [
3382
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Embryophyta"
] | [
3382
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
27,
13,
15
] | 3 | true | Domain | Domain of unknown function DUF7054 | Domain of unknown function DUF7054 | DUF7054 | 6 |
IPR055483 | 55,483 | Domain of unknown function DUF7055 | DUF7055 | Domain | 15 | false | false | This is a presumed domain found in a group of uncharacterised sequences from bacteria. According to structure predictions, this domain is found at the C-terminal and may adopt an all-β structure consisting of eight anti-parallel β-sheets. These proteins also have a glycosyltransferase domain at the N-terminal ( ). | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23157"
] | [
"DUF7055"
] | [
15
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Pseudomonadota",
"hydrothermal vent metagenome"
] | [
14,
1
] | 2 | [] | [] | 0 | true | Domain | Domain of unknown function DUF7055 | Domain of unknown function DUF7055 | DUF7055 | 5 |
IPR055484 | 55,484 | Domain of unknown function DUF7056 | DUF7056 | Domain | 20 | false | false | This is a presumed domain found in a group of uncharacterised sequences from bacteria. According to structure predictions, this domain is found towards the C-terminal, after a glycosyltransferase domain ( ), and it may adopt an α/β structure. In some instances, this domain is followed by and all-β domain at the very C-... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23158"
] | [
"DUF7056"
] | [
20
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Pseudomonadati",
"hydrothermal vent metagenome"
] | [
18,
2
] | 2 | [] | [] | 0 | true | Domain | Domain of unknown function DUF7056 | Domain of unknown function DUF7056 | DUF7056 | 7 |
IPR055485 | 55,485 | Domain of unknown function DUF7057 | DUF7057 | Domain | 43 | false | false | This is a presumed domain found at the C-terminal of sequences from Gammaproteobacteria. According to structure predictions it may have an α/β fold. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23167"
] | [
"DUF7057"
] | [
43
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Knufia peltigerae"
] | [
42,
1
] | 2 | [] | [] | 0 | true | Domain | Domain of unknown function DUF7057 | Domain of unknown function DUF7057 | DUF7057 | 8 |
IPR055486 | 55,486 | CUL7/CUL9, N-terminal domain | CUL7/CUL9_N | Domain | 1,567 | false | false | This domain is found N-terminal in the homologues of human Cullin-7 and Cullin-9. It adopts a β-barrel structure with some similarity to chromodomains and is known as a small beta-domain (SBD) [ , ]. This domain is usually followed by an ARM-like domain. Cullins are a family of hydrophobic proteins that act as scaffold... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23168"
] | [
"CUL7_CUL9_N"
] | [
1567
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-381038",
"R-HSA-8951664",
"R-HSA-983168",
"R-MMU-983168",
"R-RNO-8951664",
"R-RNO-983168"
] | [
"REACTOME:R-HSA-381038",
"REACTOME:R-HSA-8951664",
"REACTOME:R-HSA-983168",
"REACTOME:R-MMU-983168",
"REACTOME:R-RNO-8951664",
"REACTOME:R-RNO-983168"
] | 6 | [
"7z8b",
"8q7e",
"8q7h",
"8rhz"
] | 4 | [
"PUB00000937",
"PUB00010627",
"PUB00031678",
"PUB00042618",
"PUB00075111",
"PUB00103546",
"PUB00155195",
"PUB00156050"
] | [
"8681378",
"11961546",
"15537541",
"15688063",
"24793696",
"36041947",
"38605244",
"35982156"
] | [
"cul-1 is required for cell cycle exit in C. elegans and identifies a novel gene family.",
"Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex.",
"Structure of the Cand1-Cul1-Roc1 complex reveals regulatory mechanisms for the assembly of the multisubunit cullin-dependent ubiquitin ligases.",... | [
1996,
2002,
2004,
2005,
2014,
2023,
2024,
2022
] | 8 | [] | [] | 0 | 0 | null | [
"Chordata"
] | [
1567
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
10,
8,
7
] | 4 | true | Domain | CUL7/CUL9, N-terminal domain | CUL7/CUL9, N-terminal domain | CUL7/CUL9_N | 4 |
IPR055487 | 55,487 | Domain of unknown function DUF7059 | DUF7059 | Domain | 3,830 | false | false | This domain is found N-terminal in a group of uncharacterised bacterial proteins. These proteins are probably distantly related to Aeronamide N-methyltransferases AerE. They share two similar domains that are predicted in the same arrangement. This domain is found N-terminal to the methyltransferase domain and has a we... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23186"
] | [
"DUF7059"
] | [
3830
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Pleodorina starrii",
"metagenomes"
] | [
3822,
1,
7
] | 3 | [] | [] | 0 | true | Domain | Domain of unknown function DUF7059 | Domain of unknown function DUF7059 | DUF7059 | 9 |
IPR055489 | 55,489 | Domain of unknown function DUF7061 | DUF7061 | Domain | 24 | false | false | This entry represents a domain found towards the N-terminal of a group of proteins from nematodes such as Trichuris suis and Trichinella britovi, members of the BPI/LBP/Plunc family of proteins which share homology with cholesterol ester transfer protein (CETP) and phospholipid transfer protein (PLTP). The exact functi... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23200"
] | [
"DUF7061"
] | [
24
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Trichinellida"
] | [
24
] | 1 | [] | [] | 0 | true | Domain | Domain of unknown function DUF7061 | Domain of unknown function DUF7061 | DUF7061 | 6 |
IPR055490 | 55,490 | Domain of unknown function DUF7062 | DUF7062 | Domain | 36 | false | false | This domain is found in a group of uncharacterised proteins from digenean species. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23201"
] | [
"DUF7062"
] | [
36
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Digenea"
] | [
36
] | 1 | [] | [] | 0 | true | Domain | Domain of unknown function DUF7062 | Domain of unknown function DUF7062 | DUF7062 | 6 |
IPR055491 | 55,491 | Domain of unknown function DUF7063 | DUF7063 | Domain | 122 | false | false | This is a SH2 domain found mainly in nematodes such as Trichuris trichura, Toxocara canis and Trichinella sp. The function of this domain is unknown. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23205"
] | [
"DUF7063"
] | [
122
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Ecdysozoa"
] | [
122
] | 1 | [] | [] | 0 | true | Domain | Domain of unknown function DUF7063 | Domain of unknown function DUF7063 | DUF7063 | 3 |
IPR055492 | 55,492 | Domain of unknown function DUF7064 | DUF7064 | Domain | 1,325 | false | false | This is a domain of unknown function found in fungi, bacteria and archaea, which, according to structure predictions it adopts a lipocalin-like fold. This domain is found as a pair of two flattened, orthogonally packed, beta-barrels. This entry represents the C-terminal barrel of the pair. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23212"
] | [
"DUF7064"
] | [
1325
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Opisthokonta",
"ecological metagenomes"
] | [
18,
992,
245,
70
] | 4 | [
"Caenorhabditis elegans"
] | [
1
] | 1 | true | Domain | Domain of unknown function DUF7064 | Domain of unknown function DUF7064 | DUF7064 | 4 |
IPR055493 | 55,493 | Domain of unknown function DUF7065 | DUF7065 | Domain | 801 | false | false | This is a domain of unknown function found in fungi and bacteria, which, according to structure predictions it adopts a lipocalin-like fold. This domain is found as a pair of two flattened, orthogonally packed, beta-barrels. This entry represents the N-terminal barrel of the pair. In some members, the lipocalin-like do... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23213"
] | [
"DUF7065"
] | [
801
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"ecological metagenomes"
] | [
17,
667,
46,
71
] | 4 | [] | [] | 0 | true | Domain | Domain of unknown function DUF7065 | Domain of unknown function DUF7065 | DUF7065 | 6 |
IPR055494 | 55,494 | Domain of unknown function DUF7066 | DUF7066 | Domain | 1,000 | false | false | This is a beta-beta-alpha zinc finger found in a group of uncharacterised sequences, mainly from fungi. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23217"
] | [
"DUF7066"
] | [
1000
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1000
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus"
] | [
8,
1,
1
] | 3 | true | Domain | Domain of unknown function DUF7066 | Domain of unknown function DUF7066 | DUF7066 | 1 |
IPR055495 | 55,495 | Alpha-glucan water dikinase, DUF7067 | CWD_DUF7067 | Domain | 1,135 | false | false | This domain is found in in Alpha-glucan water dikinase (GWD1 and GWD2) from Arabidopsis thaliana and in two-tandem copies in GWD1 from Citrus reticulata and Solanum tuberosum. It is predicted to adopt a globular structure consisting of a three helical bundle. GWD1 is involved in the incorporation of phosphate into star... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23229"
] | [
"DUF7067"
] | [
1135
] | 1 | [
"EC",
"METACYC"
] | [
"2.7.9.4",
"PWY-6724"
] | [
"EC:2.7.9.4",
"METACYC:PWY-6724"
] | 2 | [] | 0 | [
"PUB00153995"
] | [
"11487701"
] | [
"The Arabidopsis sex1 mutant is defective in the R1 protein, a general regulator of starch degradation in plants, and not in the chloroplast hexose transporter."
] | [
2001
] | 1 | [] | [] | 0 | 0 | null | [
"Viridiplantae"
] | [
1135
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
9,
3,
7
] | 3 | true | Domain | Alpha-glucan water dikinase, DUF7067 | Alpha-glucan water dikinase, DUF7067 | CWD_DUF7067 | 8 |
IPR055498 | 55,498 | Domain of unknown function DUF7070 | DUF7070 | Domain | 254 | false | false | This domain is found in a group of uncharacterised proteins mainly from actinopterygians that are distantly related and share overall similar domain organisation to the human NEDD4-binding protein 1 (N4BP1). This domain shares a weak sequence similarity to known UBA domains and it is predicted to fold into a typical th... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23255"
] | [
"DUF7070"
] | [
254
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Euteleostomi"
] | [
254
] | 1 | [
"Danio rerio"
] | [
3
] | 1 | true | Domain | Domain of unknown function DUF7070 | Domain of unknown function DUF7070 | DUF7070 | 3 |
IPR055499 | 55,499 | Domain of unknown function DUF7071 | DUF7071 | Domain | 1,159 | false | false | This domain is found C-terminal in a group of uncharacterised proteins mainly from fungi. It is predicted to adopt a globular structure consisting of two α-helical repeats. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23257"
] | [
"DUF7071"
] | [
1159
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1159
] | 1 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)"
] | [
1
] | 1 | true | Domain | Domain of unknown function DUF7071 | Domain of unknown function DUF7071 | DUF7071 | 6 |
IPR055500 | 55,500 | Domain of unknown function DUF7072 | DUF7072 | Domain | 1,102 | false | false | This domain is found in a group of uncharacterised proteins mainly from Fungi. It shares a weak sequence similarity to the C-terminal domain of the Escherichia Coli ProQ RNA binding protein (Pfam:PF17516) and it is predicted to adopt a similar structure with SH3-like topology. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23258"
] | [
"DUF7072"
] | [
1102
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Opisthokonta"
] | [
1102
] | 1 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)"
] | [
1
] | 1 | true | Domain | Domain of unknown function DUF7072 | Domain of unknown function DUF7072 | DUF7072 | 4 |
IPR055501 | 55,501 | Domain of unknown function DUF7073 | DUF7073 | Domain | 67 | false | false | This domain is found in Histone-lysine N-methyltransferase, H3 lysine-4 specific from Plasmodium falciparum ( ) and similar sequences from alveolates. In some proteins this domain is found associated with . It shows a conserved motif LLxxYKxKI/LxDLL. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23264"
] | [
"DUF7073"
] | [
67
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
67
] | 1 | [] | [] | 0 | true | Domain | Domain of unknown function DUF7073 | Domain of unknown function DUF7073 | DUF7073 | 1 |
IPR055502 | 55,502 | Domain of unknown function DUF7074 | DUF7074 | Domain | 1,391 | false | false | This domain is found in a group of uncharacterised plant proteins. It is predicted to adopt a globular structure with a Cystatin-like topology consisting of a curved four-stranded β-sheet and an α-helix packed on the concave side of it. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23269"
] | [
"DUF7074"
] | [
1391
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Streptophyta"
] | [
1391
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
11,
8,
6
] | 3 | true | Domain | Domain of unknown function DUF7074 | Domain of unknown function DUF7074 | DUF7074 | 7 |
IPR055503 | 55,503 | Domain of unknown function DUF7075 | DUF7075 | Domain | 1,523 | false | false | This domain is found in a group of uncharacterised plant proteins. It shares a significant sequence similarity with members of the GDP-fucose protein O-fucosyltransferase family (Pfam:PF10250) and it is predicted to adopt similar structure. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23272"
] | [
"DUF7075"
] | [
1523
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1523
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
15,
10,
9
] | 3 | true | Domain | Domain of unknown function DUF7075 | Domain of unknown function DUF7075 | DUF7075 | 3 |
IPR055504 | 55,504 | Domain of unknown function DUF7076 | DUF7076 | Domain | 151 | false | false | This domain is found in a group of uncharacterised proteins mainly from fungi. It shares a significant sequence similarity of Ig-like domains found in Trs120 and it is predicted to adopt a structure with a similar topology. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23273"
] | [
"DUF7076"
] | [
151
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Fungi"
] | [
151
] | 1 | [] | [] | 0 | true | Domain | Domain of unknown function DUF7076 | Domain of unknown function DUF7076 | DUF7076 | 9 |
IPR055505 | 55,505 | Domain of unknown function DUF7077 | DUF7077 | Domain | 1,501 | false | false | This domain is found in a group of uncharacterised proteins mainly from fungi. It shares a weak sequence similarity with the Ig-like domains found in Trs130, particularly the second Ig-like domain, and it is predicted to adopt a structure with a similar topology. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23274"
] | [
"DUF7077"
] | [
1501
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1501
] | 1 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)"
] | [
1
] | 1 | true | Domain | Domain of unknown function DUF7077 | Domain of unknown function DUF7077 | DUF7077 | 5 |
IPR055506 | 55,506 | Domain of unknown function DUF7078 | DUF7078 | Domain | 56 | false | false | This domain is found in uncharacterised proteins mainly from fungi. This domain is predicted to adopt a globular structure consisting of a four helical bundle and having structural similarity to the α-helical domain inserted in the third Ig domain of the Trs130 component of the TRAPPII complex [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23285"
] | [
"DUF7078"
] | [
56
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00153720"
] | [
"35080977"
] | [
"Structural basis for assembly of TRAPPII complex and specific activation of GTPase Ypt31/32."
] | [
2022
] | 1 | [] | [] | 0 | 0 | null | [
"Dikarya"
] | [
56
] | 1 | [] | [] | 0 | true | Domain | Domain of unknown function DUF7078 | Domain of unknown function DUF7078 | DUF7078 | 6 |
IPR055507 | 55,507 | Domain of unknown function DUF7079 | DUF7079 | Domain | 932 | false | false | This is a presumed domain found in a set of bacterial sequences, whose function is unknown. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23296"
] | [
"DUF7079"
] | [
932
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Dikarya",
"metagenomes"
] | [
880,
44,
8
] | 3 | [] | [] | 0 | true | Domain | Domain of unknown function DUF7079 | Domain of unknown function DUF7079 | DUF7079 | 4 |
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