interpro_id string | interpro_numeric_id int64 | name string | short_name string | entry_type string | protein_count int64 | is_llm bool | is_llm_reviewed bool | abstract string | go_ids list | go_terms list | go_categories list | go_count int64 | member_databases list | member_accessions list | member_names list | member_protein_counts list | member_count int64 | external_databases list | external_accessions list | external_xrefs list | external_xref_count int64 | pdb_ids list | structure_count int64 | publication_ids list | pubmed_ids list | publication_titles list | publication_years list | publication_count int64 | parent_ids list | child_ids list | parent_count int64 | child_count int64 | tree_depth float64 | taxonomy_names list | taxonomy_protein_counts list | taxonomy_count int64 | key_species_names list | key_species_protein_counts list | key_species_count int64 | in_entry_list bool | entry_list_type string | entry_list_name string | names_dat_name string | short_names_dat_name string | split_bucket int64 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
IPR055271 | 55,271 | Neuron-derived neurotrophic factor, first Fn(III) domain | NDNF_Fn(III)_1 | Domain | 1,932 | false | false | This domain is found centrally located in animal Neuron-derived neurotrophic factor (NDNF), which contains a fibronectin type III domain and one of the predicted N-linked glycosylation sites [ , ]. NDNF is a glycosylated and disulfide-bonded secreted protein expressed in brain and spinal cord that promotes migration an... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF10179"
] | [
"NDNF"
] | [
1932
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00092492",
"PUB00092493"
] | [
"24706764",
"20969804"
] | [
"Neuron-derived neurotrophic factor functions as a novel modulator that enhances endothelial cell function and revascularization processes.",
"Spatio-temporal expression of a novel neuron-derived neurotrophic factor (NDNF) in mouse brains during development."
] | [
2014,
2010
] | 2 | [] | [] | 0 | 0 | null | [
"Bilateria"
] | [
1932
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
4,
4,
1,
1,
3
] | 6 | true | Domain | Neuron-derived neurotrophic factor, first Fn(III) domain | Neuron-derived neurotrophic factor, first Fn(III) domain | NDNF_Fn(III)_1 | 2 |
IPR055273 | 55,273 | CBG09102/CBG15751-like domain | CBG09102/CBG15751-like_dom | Domain | 90 | false | false | This entry represents a domain found in a group of uncharacterised sequences from nematodes, including CBG09102 and CBG15751 from Caenorhabditis briggsae. This domain may adopt a β-sandwich fold consisting of thirteen β-strands. | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR40314"
] | [
""
] | [
90
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Rhabditina"
] | [
90
] | 1 | [
"Caenorhabditis elegans"
] | [
3
] | 1 | true | Domain | CBG09102/CBG15751-like domain | CBG09102/CBG15751-like domain | CBG09102/CBG15751-like_dom | 3 |
IPR055274 | 55,274 | SWOLLEN 1 | SWO1 | Family | 1,469 | false | false | This family represents a group of plant sequences, including SWOLLEN 1 (SWO1, ) from Arabidopsis thaliana. SWO1 is an Agenet domain-containing protein, required for the maintenance of cell wall integrity under salt stress, through the interaction with importin alpha [ ]. | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR48429"
] | [
""
] | [
1469
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00155287"
] | [
"37676567"
] | [
"SWO1 modulates cell wall integrity under salt stress by interacting with importin ɑ in Arabidopsis."
] | [
2021
] | 1 | [] | [] | 0 | 0 | null | [
"Embryophyta"
] | [
1469
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
6,
7,
47
] | 3 | true | Family | SWOLLEN 1 | SWOLLEN 1 | SWO1 | 7 |
IPR055276 | 55,276 | NHL41-like | NHL41-like | Family | 1,181 | false | false | This family represents a group of plant proteins, including NHL41 from Arabidopsis thaliana (also known as late embryogenesis abundant protein, AT3G24600, ) which may play a role in abscisic acid and stress response [ ]. | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR48436"
] | [
""
] | [
1181
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00155288"
] | [
"27110948"
] | [
"Role of Arabidopsis NHL family in ABA and stress response."
] | [
2016
] | 1 | [] | [] | 0 | 0 | null | [
"Embryophyta"
] | [
1181
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
10,
2,
4
] | 3 | true | Family | NHL41-like | NHL41-like | NHL41-like | 2 |
IPR055277 | 55,277 | Fanconi anaemia group A protein, C-terminal | Fanconi_A_C | Domain | 941 | false | false | This domain is found towards the C-terminal of human Fanconi anaemia group A protein (FANCA) and related proteins. It contains ARM repeats. Fanconi anemia (FA) is a human disorder characterised by cancer susceptibility and cellular sensitivity to DNA crosslinks and other damages. The FA complex repairs the interstrand ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF03511"
] | [
"FANCA_CTD"
] | [
941
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-6783310",
"R-HSA-9833482",
"R-MMU-6783310",
"R-MMU-9833482"
] | [
"REACTOME:R-HSA-6783310",
"REACTOME:R-HSA-9833482",
"REACTOME:R-MMU-6783310",
"REACTOME:R-MMU-9833482"
] | 4 | [
"6lhs",
"6lhu",
"7kzp",
"7kzq",
"7kzr",
"7kzs",
"7kzt",
"7kzv"
] | 8 | [
"PUB00054178",
"PUB00089968"
] | [
"20347428",
"29017571"
] | [
"A histone-fold complex and FANCM form a conserved DNA-remodeling complex to maintain genome stability.",
"DNA damage response and cancer therapeutics through the lens of the Fanconi Anemia DNA repair pathway."
] | [
2010,
2017
] | 2 | [] | [] | 0 | 0 | null | [
"Vertebrata"
] | [
941
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
8,
4,
5
] | 4 | true | Domain | Fanconi anaemia group A protein, C-terminal | Fanconi anaemia group A protein, C-terminal | Fanconi_A_C | 5 |
IPR055278 | 55,278 | Cell division control protein 48 homolog C | CDC48c | Family | 1,545 | false | false | This entry represents Cell division control protein 48 homolog C from Arabidopsis thaliana (CDC48c) and similar proteins predominantly found in plants. CDC48c is thought to function in cell division and growth processes. Members of this group contain an ATPase domain ( ). | [
"GO:0016887"
] | [
"ATP hydrolysis activity"
] | [
"molecular_function"
] | 1 | [
"PANTHER"
] | [
"PTHR48470"
] | [
""
] | [
1545
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1545
] | 1 | [
"Arabidopsis thaliana",
"Drosophila melanogaster",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
11,
1,
2,
30
] | 4 | true | Family | Cell division control protein 48 homolog C | Cell division control protein 48 homolog C | CDC48c | 2 |
IPR055280 | 55,280 | Short-chain dehydrogenase TIC 32 | TIC32 | Family | 4,652 | false | false | This entry represents Short-chain dehydrogenase TIC 32, chloroplastic from Pisum sativum (TIC32) and similar plant proteins. TIC32 is involved in protein precursor import into chloroplasts. It is part of the redox regulon that consists of TIC32, TIC 55 and TIC62 [ ]. | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR48476"
] | [
""
] | [
4652
] | 1 | [
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC"... | [
"1.1.1.-",
"PWY-1121",
"PWY-1186",
"PWY-2541",
"PWY-2601",
"PWY-3162",
"PWY-321",
"PWY-3261",
"PWY-3722",
"PWY-5101",
"PWY-5271",
"PWY-5316",
"PWY-5392",
"PWY-5652",
"PWY-5666",
"PWY-5751",
"PWY-5782",
"PWY-5818",
"PWY-5830",
"PWY-5848",
"PWY-5867",
"PWY-5882",
"PWY-5883"... | [
"EC:1.1.1.-",
"METACYC:PWY-1121",
"METACYC:PWY-1186",
"METACYC:PWY-2541",
"METACYC:PWY-2601",
"METACYC:PWY-3162",
"METACYC:PWY-321",
"METACYC:PWY-3261",
"METACYC:PWY-3722",
"METACYC:PWY-5101",
"METACYC:PWY-5271",
"METACYC:PWY-5316",
"METACYC:PWY-5392",
"METACYC:PWY-5652",
"METACYC:PWY-56... | 148 | [] | 0 | [
"PUB00155289"
] | [
"17035502"
] | [
"Calcium regulation of chloroplast protein translocation is mediated by calmodulin binding to Tic32."
] | [
2006
] | 1 | [
"IPR002347"
] | [] | 1 | 0 | 1 | [
"Bacteria",
"Eukaryota"
] | [
9,
4643
] | 2 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
33,
34,
36
] | 3 | true | Family | Short-chain dehydrogenase TIC 32 | Short-chain dehydrogenase TIC 32 | TIC32 | 9 |
IPR055281 | 55,281 | GIR1-2/SIED1 | GIR1-2/SIED1 | Family | 3,184 | false | false | This family of proteins includes protein GL2-INTERACTING REPRESSOR 1/2 (GIR1/2) and their paralogue, protein salt-induced and EIN3/EIL1-dependent 1 (SIED1), which regulators of plant development and stress responses. GIR1/2 are involved in the modulation of root hair development and act as negative regulators in this p... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR33177"
] | [
""
] | [
3184
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00155290",
"PUB00155291",
"PUB00155292"
] | [
"25330213",
"28526410",
"28526412"
] | [
"Salt-induced stabilization of EIN3/EIL1 confers salinity tolerance by deterring ROS accumulation in Arabidopsis.",
"Adaptor proteins GIR1 and GIR2. I. Interaction with the repressor GLABRA2 and regulation of root hair development.",
"Adaptor proteins GIR1 and GIR2. II. Interaction with the co-repressor TOPLESS... | [
2014,
2017,
2017
] | 3 | [] | [] | 0 | 0 | null | [
"Embryophyta"
] | [
3184
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
21,
21,
38
] | 3 | true | Family | GIR1-2/SIED1 | GIR1-2/SIED1 | GIR1-2/SIED1 | 1 |
IPR055282 | 55,282 | Proton pump-interactor 1-4 | PPI1-4 | Family | 2,343 | false | false | The Proton pump-interactor protein family (PPI, which includes PPI1-4 from Arabidopsis and BIP103/131 from rice) is implicated in the regulation of plasma membrane ATPase activity in plants. Members of this family may interact with the plasma membrane ATPases, such as AHA1, to modulate their activity [ , , , ]. PPI2 is... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR32219"
] | [
""
] | [
2343
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00070626",
"PUB00155293",
"PUB00155363",
"PUB00155364"
] | [
"16279950",
"12182706",
"18304198",
"32554506"
] | [
"Characterization of the interaction between the plasma membrane H-ATPase of Arabidopsis thaliana and a novel interactor (PPI1).",
"A novel interaction partner for the C-terminus of Arabidopsis thaliana plasma membrane H+-ATPase (AHA1 isoform): site and mechanism of action on H+-ATPase activity differ from those ... | [
2005,
2002,
2008,
2020
] | 4 | [] | [] | 0 | 0 | null | [
"Viridiplantae"
] | [
2343
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
32,
5,
24
] | 3 | true | Family | Proton pump-interactor 1-4 | Proton pump-interactor 1-4 | PPI1-4 | 2 |
IPR055284 | 55,284 | Galaxin-like | Galaxin-like | Family | 809 | false | false | This family of proteins includes galaxins and related proteins that share common structural features such as the presence of repetitive motifs containing dicysteine residues. Galaxins are characterised by their role in biomineralization processes [ ]. These proteins are typically involved in the formation of calcium ca... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR34490"
] | [
""
] | [
809
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00155296"
] | [
"19638240"
] | [
"Differential expression of three galaxin-related genes during settlement and metamorphosis in the scleractinian coral Acropora millepora."
] | [
2009
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Methanospirillum",
"viral metagenome"
] | [
2,
796,
10,
1
] | 4 | [
"Caenorhabditis elegans",
"Danio rerio"
] | [
1,
12
] | 2 | true | Family | Galaxin-like | Galaxin-like | Galaxin-like | 7 |
IPR055285 | 55,285 | Ankyrin repeat domain-containing protein 13, C-terminal | ANKRD13_C | Domain | 9,631 | false | false | This entry represents the C-terminal domain of ankyrin repeat domain-containing protein 13 (ANKRD13). At least 4 subtypes are known to exist, termed A-D. ANKRD13C has been experimentally characterised and acts as a chaperone for biogenesis and folding of the DP receptor for prostaglandin D2 [ ]. ANKRD13A/B/D are ubiqui... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF11904"
] | [
"ANKRD13_C"
] | [
9631
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00057233",
"PUB00155297"
] | [
"20959461",
"22298428"
] | [
"ANKRD13C acts as a molecular chaperone for G protein-coupled receptors.",
"The Ankrd 13 family of UIM-bearing proteins regulates EGF receptor endocytosis from the plasma membrane."
] | [
2010,
2012
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
9631
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
29,
2,
9,
6,
18,
11,
15,
16,
25
] | 9 | true | Domain | Ankyrin repeat domain-containing protein 13, C-terminal | Ankyrin repeat domain-containing protein 13, C-terminal | ANKRD13_C | 3 |
IPR055286 | 55,286 | Ribitol-5-phosphate xylosyltransferase 1-like | RXYLT1-like | Family | 1,626 | false | false | This entry represents human Ribitol-5-phosphate xylosyltransferase 1 (RXYLT1) and similar proteins predominantly found in animals. RXYLT1 acts as a UDP-D-xylose:ribitol-5-phosphate beta1,4-xylosyltransferase, which catalyses the transfer of UDP-D-xylose to ribitol 5-phosphate (Rbo5P) to form the Xylbeta1-4Rbo5P linkage... | [
"GO:0120053",
"GO:0035269"
] | [
"ribitol beta-1,4-xylosyltransferase activity",
"protein O-linked glycosylation via mannose"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PANTHER"
] | [
"PTHR15576"
] | [
""
] | [
1626
] | 1 | [
"EC",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"2.4.2.61",
"PWY-7981",
"R-DRE-9939291",
"R-HSA-9939291",
"R-MMU-9939291"
] | [
"EC:2.4.2.61",
"METACYC:PWY-7981",
"REACTOME:R-DRE-9939291",
"REACTOME:R-HSA-9939291",
"REACTOME:R-MMU-9939291"
] | 5 | [] | 0 | [
"PUB00098859",
"PUB00155298",
"PUB00155299"
] | [
"29477842",
"27130732",
"27733679"
] | [
"Cell endogenous activities of fukutin and FKRP coexist with the ribitol xylosyltransferase, TMEM5.",
"The functional O-mannose glycan on α-dystroglycan contains a phospho-ribitol primed for matriglycan addition.",
"The Muscular Dystrophy Gene TMEM5 Encodes a Ribitol β1,4-Xylosyltransferase Required for the Fun... | [
2018,
2016,
2016
] | 3 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Candidatus Lokiarchaeum ossiferum",
"Eukaryota",
"Viruses",
"metagenomes"
] | [
32,
1,
1529,
3,
61
] | 5 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
5,
2,
2
] | 4 | true | Family | Ribitol-5-phosphate xylosyltransferase 1-like | Ribitol-5-phosphate xylosyltransferase 1-like | RXYLT1-like | 1 |
IPR055287 | 55,287 | Interleukin-16-like | IL-16-like | Family | 1,849 | false | false | This entry represents human interleukin-16 (IL-16) and similar sequences from vertebrates and arthropods. Interleukins (IL) are a group of cytokines that play an important role in the immune system. They modulate inflammation and immunity by regulating growth, mobility and differentiation of lymphoid and other cells. I... | [
"GO:0005125",
"GO:0050930"
] | [
"cytokine activity",
"induction of positive chemotaxis"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PANTHER"
] | [
"PTHR48484"
] | [
""
] | [
1849
] | 1 | [
"REACTOME",
"REACTOME"
] | [
"R-HSA-449836",
"R-MMU-449836"
] | [
"REACTOME:R-HSA-449836",
"REACTOME:R-MMU-449836"
] | 2 | [
"1i16",
"1x6d",
"5fb8"
] | 3 | [
"PUB00046078",
"PUB00046079",
"PUB00155303",
"PUB00155304"
] | [
"7910967",
"16881862",
"16271292",
"16387589"
] | [
"Molecular and functional analysis of a lymphocyte chemoattractant factor: association of biologic function with CD4 expression.",
"Not-so-sweet sixteen: the role of IL-16 in infectious and immune-mediated inflammatory diseases.",
"Increased levels of bioactive IL-16 correlate with disease activity during relap... | [
1994,
2006,
2005,
2006
] | 4 | [] | [
"IPR020450"
] | 0 | 1 | 0 | [
"Eumetazoa"
] | [
1849
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
5,
16,
3,
7
] | 4 | true | Family | Interleukin-16-like | Interleukin-16-like | IL-16-like | 7 |
IPR055288 | 55,288 | NALCN channel auxiliary factor 1/2 | NALCN_aux_factor_1/2 | Family | 2,256 | false | false | This family of proteins includes auxiliary components of the NALCN sodium channel complex, NALF1/2 [ ]. These proteins are involved in regulating the resting membrane potential and controlling neuronal excitability [ ]. They are likely to interact with the NALCN channel to modulate its function and play a crucial role ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR15819"
] | [
""
] | [
2256
] | 1 | [] | [] | [] | 0 | [
"6xiw",
"7cm3",
"7cu3",
"7sx3",
"7sx4",
"7w7g",
"7wji"
] | 7 | [
"PUB00100244"
] | [
"32494638"
] | [
"The NALCN channel complex is voltage sensitive and directly modulated by extracellular calcium."
] | [
2020
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
2256
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
6,
2,
2,
2,
5
] | 5 | true | Family | NALCN channel auxiliary factor 1/2 | NALCN channel auxiliary factor 1/2 | NALCN_aux_factor_1/2 | 9 |
IPR055289 | 55,289 | Centriole and centriolar satellite OFD1 | OFD1 | Family | 1,929 | false | false | This family of proteins, which includes centriole and centriolar satellite protein OFD1, is involved in the structural integrity and functional regulation of centrioles, which are critical for cell division and signaling. Members of this family play a key role in determining the length of mother and daughter centrioles... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR39063"
] | [
""
] | [
1929
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-2565942",
"R-HSA-380259",
"R-HSA-380270",
"R-HSA-380284",
"R-HSA-380320",
"R-HSA-5610787",
"R-HSA-5620912",
"R-HSA-8854518",
"R-MMU-2565942",
"R-MMU-380259",
"R-MMU-380270",
"R-MMU-380284",
"R-MMU-380320",
"R-MMU-5610787",
"R-MMU-5620912",
"R-MMU-8854518"
] | [
"REACTOME:R-HSA-2565942",
"REACTOME:R-HSA-380259",
"REACTOME:R-HSA-380270",
"REACTOME:R-HSA-380284",
"REACTOME:R-HSA-380320",
"REACTOME:R-HSA-5610787",
"REACTOME:R-HSA-5620912",
"REACTOME:R-HSA-8854518",
"REACTOME:R-MMU-2565942",
"REACTOME:R-MMU-380259",
"REACTOME:R-MMU-380270",
"REACTOME:R-MM... | 16 | [] | 0 | [
"PUB00155305",
"PUB00155306",
"PUB00155307"
] | [
"18084282",
"20230748",
"33934390"
] | [
"Kif3a constrains beta-catenin-dependent Wnt signalling through dual ciliary and non-ciliary mechanisms.",
"Ofd1, a human disease gene, regulates the length and distal structure of centrioles.",
"The TBC1D31/praja2 complex controls primary ciliogenesis through PKA-directed OFD1 ubiquitylation."
] | [
2008,
2010,
2021
] | 3 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Haloarchaeobius litoreus"
] | [
2,
1926,
1
] | 3 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
4,
14,
4,
5
] | 4 | true | Family | Centriole and centriolar satellite OFD1 | Centriole and centriolar satellite OFD1 | OFD1 | 9 |
IPR055290 | 55,290 | F-box protein At3g26010-like | At3g26010-like | Family | 9,309 | false | false | This entry represents F-box protein At3g26010 from Arabidopsis thaliana and similar plant proteins. At3g26010 is a galactose oxidase/kelch repeat superfamily protein. Members of this family contain an F-box domain or an F-box associated interaction domain. | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR35546"
] | [
""
] | [
9309
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Magnoliopsida"
] | [
9309
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
27,
77,
54
] | 3 | true | Family | F-box protein At3g26010-like | F-box protein At3g26010-like | At3g26010-like | 1 |
IPR055292 | 55,292 | Mitogen-activated protein kinase-binding protein 1 | MABP1 | Family | 2,215 | false | false | This entry represents the Mitogen-activated protein kinase-binding protein 1 (MAPKBP1, also known as JNKBP1) and related proteins. Members of this family contain two WD40 domains at the N-terminal that mediate interaction with NOD2, leading to the down-regulation of NOD2-induced signalling pathways [ ]. These proteins ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR44813"
] | [
""
] | [
2215
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00155314",
"PUB00155315"
] | [
"10471813",
"22700971"
] | [
"A novel Jun N-terminal kinase (JNK)-binding protein that enhances the activation of JNK by MEK kinase 1 and TGF-beta-activated kinase 1.",
"The c-Jun N-terminal kinase (JNK)-binding protein (JNKBP1) acts as a negative regulator of NOD2 protein signaling by inhibiting its oligomerization process."
] | [
1999,
2012
] | 2 | [] | [] | 0 | 0 | null | [
"Opisthokonta"
] | [
2215
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
16,
12,
4,
3
] | 4 | true | Family | Mitogen-activated protein kinase-binding protein 1 | Mitogen-activated protein kinase-binding protein 1 | MABP1 | 1 |
IPR055294 | 55,294 | F-box/LRR-repeat protein At3g58940-like | FBL60-like | Family | 4,503 | false | false | This entry represents F-box/LRR-repeat protein At3g58940 from Arabidopsis thaliana (FBL60) and similar plant proteins. | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR31293"
] | [
""
] | [
4503
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Magnoliopsida"
] | [
4503
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica"
] | [
337,
2
] | 2 | true | Family | F-box/LRR-repeat protein At3g58940-like | F-box/LRR-repeat protein At3g58940-like | FBL60-like | 4 |
IPR055295 | 55,295 | Uridine diphosphate glucose pyrophosphatase NUDT22/Nudix hydrolase 9-like | NUDT22/NUDT9-like | Family | 1,720 | false | false | This entry represents a family of eukaryotic proteins, including animal Uridine diphosphate glucose pyrophosphatase NUDT22 and plant Nudix hydrolase 9 (NUDT9). NUDT22 hydrolyses UDP-glucose to glucose 1-phosphate and UMP and UDP-galactose to galactose 1-phosphate and UMP. Preferred substrate is UDP-glucose [ ]. | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR31835"
] | [
""
] | [
1720
] | 1 | [
"EC"
] | [
"3.6.1.45"
] | [
"EC:3.6.1.45"
] | 1 | [
"5lf9",
"5lor",
"5lou",
"5r50",
"5r51",
"5r52",
"5r53",
"5r54",
"5r55",
"5r56",
"5r57",
"5r58",
"5r59",
"5r5a",
"5r5b",
"5r5c",
"5r5d",
"5r5e",
"5r5f",
"5r5g",
"5r5h",
"5r5i",
"5r5j",
"5r5k",
"5r5l",
"5r5m",
"5r5n",
"5r5o",
"5r5p",
"5r5q",
"5r5r",
"5r5s"... | 33 | [
"PUB00155316"
] | [
"29413322"
] | [
"Human NUDT22 Is a UDP-Glucose/Galactose Hydrolase Exhibiting a Unique Structural Fold."
] | [
2018
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"marine sediment metagenome"
] | [
22,
1696,
2
] | 3 | [
"Arabidopsis thaliana",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
11,
3,
4,
1,
3,
3,
5
] | 7 | true | Family | Uridine diphosphate glucose pyrophosphatase NUDT22/Nudix hydrolase 9-like | Uridine diphosphate glucose pyrophosphatase NUDT22/Nudix hydrolase 9-like | NUDT22/NUDT9-like | 3 |
IPR055296 | 55,296 | SEMI-ROLLED LEAF 2-like | SRL2-like | Family | 3,972 | false | false | This entry represents the SEMI-ROLLED LEAF 2 protein (SRL2) from Oryza sativa and related plant proteins. SRL2 is involved in the regulation of leaf development, specifically in the modulation of leaf rolling [ ]. This protein is mainly expressed in the vascular bundles of leaf blades, leaf sheaths, and roots, especial... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46087"
] | [
""
] | [
3972
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00155317"
] | [
"26873975"
] | [
"Semi-Rolled Leaf2 modulates rice leaf rolling by regulating abaxial side cell differentiation."
] | [
2016
] | 1 | [] | [] | 0 | 0 | null | [
"Viridiplantae"
] | [
3972
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
26,
17,
214
] | 3 | true | Family | SEMI-ROLLED LEAF 2-like | SEMI-ROLLED LEAF 2-like | SRL2-like | 9 |
IPR055297 | 55,297 | Nebulin/Nebulette | NEBU/NEBL | Family | 8,250 | false | false | This family of proteins is involved in the structural and functional organisation of sarcomeres, the basic contractile units of muscle fibres. Members of this family bind to actin, contributing to the assembly and stabilization of the Z-disk, which is critical for muscle contraction [ , , , ]. This entry includes nebul... | [
"GO:0051015",
"GO:0030018"
] | [
"actin filament binding",
"Z disc"
] | [
"molecular_function",
"cellular_component"
] | 2 | [
"PANTHER"
] | [
"PTHR11039"
] | [
""
] | [
8250
] | 1 | [
"REACTOME"
] | [
"R-HSA-390522"
] | [
"REACTOME:R-HSA-390522"
] | 1 | [
"1ark",
"1neb",
"4f14",
"6y17"
] | 4 | [
"PUB00036336",
"PUB00085758",
"PUB00085759",
"PUB00155318",
"PUB00155319",
"PUB00155320"
] | [
"9514727",
"18823973",
"20951326",
"27733623",
"10470015",
"36661122"
] | [
"SH3 in muscles: solution structure of the SH3 domain from nebulin.",
"The nebulette repeat domain is necessary for proper maintenance of tropomyosin with the cardiac sarcomere.",
"Nebulette mutations are associated with dilated cardiomyopathy and endocardial fibroelastosis.",
"Nebulette is a powerful cytolin... | [
1998,
2008,
2010,
2016,
1999,
2023
] | 6 | [] | [
"IPR013998"
] | 0 | 1 | 0 | [
"Bilateria",
"Gammaproteobacteria"
] | [
8243,
7
] | 2 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
8,
39,
32,
26
] | 4 | true | Family | Nebulin/Nebulette | Nebulin/Nebulette | NEBU/NEBL | 9 |
IPR055299 | 55,299 | Complex I assembly factor TIMMDC1 | TIMMDC1 | Family | 2,141 | false | false | This family of proteins includes complex I assembly factor TIMMDC1 from human and its orthologues, which are mitochondrial chaperones that are involved in the assembly of the mitochondrial NADH:ubiquinone oxidoreductase complex, also known as complex I [ , , ]. Members of this family participate in constructing the mem... | [
"GO:0032981"
] | [
"mitochondrial respiratory chain complex I assembly"
] | [
"biological_process"
] | 1 | [
"PANTHER"
] | [
"PTHR13002"
] | [
""
] | [
2141
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-DME-6799198",
"R-HSA-6799198",
"R-MMU-6799198",
"R-RNO-6799198"
] | [
"REACTOME:R-DME-6799198",
"REACTOME:R-HSA-6799198",
"REACTOME:R-MMU-6799198",
"REACTOME:R-RNO-6799198"
] | 4 | [] | 0 | [
"PUB00077052",
"PUB00155322",
"PUB00155323"
] | [
"24191001",
"24344204",
"34386730"
] | [
"Assembly factors for the membrane arm of human complex I.",
"TIMMDC1/C3orf1 functions as a membrane-embedded mitochondrial complex I assembly factor through association with the MCIA complex.",
"Dissecting the concordant and disparate roles of NDUFAF3 and NDUFAF4 in mitochondrial complex I biogenesis."
] | [
2013,
2014,
2021
] | 3 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
2141
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
4,
4,
1,
1,
4,
1,
2,
4,
5
] | 9 | true | Family | Complex I assembly factor TIMMDC1 | Complex I assembly factor TIMMDC1 | TIMMDC1 | 8 |
IPR055300 | 55,300 | Cysteine-tryptophan domain-containing zinc finger protein 3/5/7 | CWZF3/5/7 | Family | 2,472 | false | false | This family of proteins includes Cysteine-tryptophan domain-containing zinc finger protein 3/5/7 and related plant sequences. Members of this entry contain a CW-type zinc finger domain ( ), which is implicated in the recognition of methylated histones, particularly histone H3 lysine 4 (H3K4me). These proteins are invol... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46524"
] | [
""
] | [
2472
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00155324",
"PUB00155325"
] | [
"28818372",
"31830332"
] | [
"Functional characterization of rice CW-domain containing zinc finger proteins involved in histone recognition.",
"Wide Grain 7 increases grain width by enhancing H3K4me3 enrichment in the OsMADS1 promoter in rice (Oryza sativa L.)."
] | [
2017,
2020
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
2472
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
23,
6,
94
] | 3 | true | Family | Cysteine-tryptophan domain-containing zinc finger protein 3/5/7 | Cysteine-tryptophan domain-containing zinc finger protein 3/5/7 | CWZF3/5/7 | 9 |
IPR055301 | 55,301 | Late embryogenesis abundant protein Lea14-like_2 | Lea14-like_2 | Family | 5,237 | false | false | This family includes Lea14-like proteins from plants. Unlike members of , most proteins in this family lack the Water Stress and Hypersensitive response (WHy) domain. Their function is not clear. LEA (late embryogenesis abundant) proteins were first identified in land plants. Plant LEA proteins have been found to accum... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR31852"
] | [
""
] | [
5237
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00009713",
"PUB00088595",
"PUB00088596"
] | [
"10681550",
"18318901",
"21034219"
] | [
"Highly hydrophilic proteins in prokaryotes and eukaryotes are common during conditions of water deficit.",
"LEA (late embryogenesis abundant) proteins and their encoding genes in Arabidopsis thaliana.",
"LEA proteins during water stress: not just for plants anymore."
] | [
2000,
2008,
2011
] | 3 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
5237
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
28,
20,
24
] | 3 | true | Family | Late embryogenesis abundant protein Lea14-like_2 | Late embryogenesis abundant protein Lea14-like_2 | Lea14-like_2 | 7 |
IPR055302 | 55,302 | F-box domain-containing protein-like | F-box_dom-containing | Family | 5,624 | false | false | This entry represents a group of uncharacterised proteins mainly from clade Poaceae that contain an F-box-like domain. | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR32141"
] | [
""
] | [
5624
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
5624
] | 1 | [
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
178,
30
] | 2 | true | Family | F-box domain-containing protein-like | F-box domain-containing protein-like | F-box_dom-containing | 1 |
IPR055303 | 55,303 | ATM interactor | ATMIN | Family | 1,565 | false | false | This family includes human ATM interactor (ATMIN, also known as ATM/ATR-substrate CHK2-interacting zinc finger protein (ASCIZ)) and related proteins from animals. These proteins are transcription factors that are essential for cell survival and the formation of RAD51 foci, a response to methylating DNA damage [ ]. Memb... | [
"GO:0000976",
"GO:0045944"
] | [
"transcription cis-regulatory region binding",
"positive regulation of transcription by RNA polymerase II"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PANTHER"
] | [
"PTHR46664"
] | [
""
] | [
1565
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00147277",
"PUB00155326",
"PUB00155327"
] | [
"22167198",
"15933716",
"17525732"
] | [
"ATM substrate Chk2-interacting Zn2+ finger (ASCIZ) Is a bi-functional transcriptional activator and feedback sensor in the regulation of dynein light chain (DYNLL1) expression.",
"ASCIZ regulates lesion-specific Rad51 focus formation and apoptosis after methylating DNA damage.",
"ATMIN defines an NBS1-independ... | [
2012,
2005,
2007
] | 3 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1565
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
2,
1,
3,
1,
4
] | 6 | true | Family | ATM interactor | ATM interactor | ATMIN | 8 |
IPR055304 | 55,304 | Coiled-coil-helix-coiled-coil-helix domain-containing protein 2/10-like | CHCHD2/10-like | Family | 5,804 | false | false | This family includes Coiled-coil-helix-coiled-coil-helix domain-containing protein 2 and 10 (CHCHD2/10) from human and its orthologues. CHCHD2/10 are homologous proteins that form a complex in the mitochondrial intermembrane space and cooperate to regulate mitochondrial function, playing a role in mitochondrial dynamic... | [
"GO:0007005"
] | [
"mitochondrion organization"
] | [
"biological_process"
] | 1 | [
"PANTHER"
] | [
"PTHR13523"
] | [
""
] | [
5804
] | 1 | [
"REACTOME",
"REACTOME"
] | [
"R-HSA-1268020",
"R-HSA-9837999"
] | [
"REACTOME:R-HSA-1268020",
"REACTOME:R-HSA-9837999"
] | 2 | [
"9cww",
"9oyo",
"9oyq",
"9oyr",
"9oys",
"9oyt",
"9oyw"
] | 7 | [
"PUB00066967",
"PUB00086618",
"PUB00155328",
"PUB00155329",
"PUB00155330",
"PUB00155331",
"PUB00155332"
] | [
"22842922",
"23303788",
"35173147",
"24934289",
"32338760",
"27308501",
"28585542"
] | [
"Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress.",
"Oxygen-dependent expression of cytochrome c oxidase subunit 4-2 gene expression is mediated by transcription factors RBPJ, CXXC5 and CHCHD2.",
"CHCHD2 and CHCHD10 regulate mitochond... | [
2012,
2013,
2022,
2014,
2020,
2015,
2017
] | 7 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
2,
5799,
3
] | 3 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
7,
1,
2,
5,
5,
6,
1,
6,
7,
1,
1,
28
] | 12 | true | Family | Coiled-coil-helix-coiled-coil-helix domain-containing protein 2/10-like | Coiled-coil-helix-coiled-coil-helix domain-containing protein 2/10-like | CHCHD2/10-like | 7 |
IPR055305 | 55,305 | Guanine nucleotide-binding protein subunit gamma 3-like | GG3-like | Family | 1,034 | false | false | This entry represents a group of proteins from plants, including Guanine nucleotide-binding protein subunit gamma 3 from Arabidopsis thaliana (GG3) [ ]. Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signalling systems. The beta and gamma chains are r... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR32378"
] | [
""
] | [
1034
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00155333",
"PUB00155334",
"PUB00155335"
] | [
"22209167",
"29487318",
"32111163"
] | [
"Gγ1+Gγ2+Gγ3=Gβ: the search for heterotrimeric G-protein γ subunits in Arabidopsis is over.",
"A G-protein pathway determines grain size in rice.",
"Heterotrimeric G protein are involved in the regulation of multiple agronomic traits and stress tolerance in rice."
] | [
2012,
2018,
2020
] | 3 | [] | [] | 0 | 0 | null | [
"Streptophytina"
] | [
1034
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
6,
10,
13
] | 3 | true | Family | Guanine nucleotide-binding protein subunit gamma 3-like | Guanine nucleotide-binding protein subunit gamma 3-like | GG3-like | 9 |
IPR055306 | 55,306 | NBPF | NBPF | Family | 1,014 | false | false | This family represents the neuroblastoma breakpoint family (NBPF) of proteins which contains a highly conserved domain of unknown function, which is known as NBPF, also known as Olduvai [ ] or DUF1220 [ ]. The NBPF/DUF1220 domain is present in multiple copies in NBPF proteins. An association has been established betwee... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR14199"
] | [
""
] | [
1014
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00043671",
"PUB00053867",
"PUB00077272",
"PUB00077275"
] | [
"16079250",
"19850849",
"25758905",
"25287832"
] | [
"A novel gene family NBPF: intricate structure generated by gene duplications during primate evolution.",
"DUF1220 Domains, Cognitive Disease, and Human Brain Evolution.",
"Replicated linear association between DUF1220 copy number and severity of social impairment in autism.",
"DUF1220 copy number is linearly... | [
2005,
2009,
2015,
2015
] | 4 | [] | [] | 0 | 0 | null | [
"Bilateria"
] | [
1014
] | 1 | [
"Homo sapiens"
] | [
119
] | 1 | true | Family | NBPF | NBPF | NBPF | 1 |
IPR055307 | 55,307 | Kinetochore protein NDC80 homolog, plants | NDC80_plants | Family | 883 | false | false | This family includes plant homologues of Kinetochore protein NDC80, mainly found in clade Streptophyta. NDC80 is essential for accurate chromosome segregation during cell division [ , ]. Members of this family are involved in the formation of the kinetochore, a critical structure that attaches chromosomes to the spindl... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR46681"
] | [
""
] | [
883
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00097609",
"PUB00155365"
] | [
"29356153",
"33993566"
] | [
"MUN (MERISTEM UNSTRUCTURED), encoding a SPC24 homolog of NDC80 kinetochore complex, affects development through cell division in Arabidopsis thaliana.",
"AtNUF2 modulates spindle microtubule organization and chromosome segregation during mitosis."
] | [
2018,
2021
] | 2 | [] | [] | 0 | 0 | null | [
"Euphyllophyta"
] | [
883
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
2,
3,
18
] | 3 | true | Family | Kinetochore protein NDC80 homolog, plants | Kinetochore protein NDC80 homolog, plants | NDC80_plants | 2 |
IPR055309 | 55,309 | Zinc finger protein 318-like | Znf318-like | Family | 1,766 | false | false | This family of proteins includes zinc finger matrin-type and zinc finger protein 318. Members of this family are involved in transcriptional regulation, acting as both coactivators and corepressors for androgen receptor (AR)-mediated transactivation [ , ]. They play a role in spermatogenesis, particularly during meioti... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR15577"
] | [
""
] | [
1766
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00155336",
"PUB00155337"
] | [
"15882980",
"16446156"
] | [
"A zinc finger protein TZF is a novel corepressor of androgen receptor.",
"Opposite effects of alternative TZF spliced variants on androgen receptor."
] | [
2005,
2006
] | 2 | [] | [] | 0 | 0 | null | [
"Cryptophlebia peltastica nucleopolyhedrovirus",
"Eukaryota"
] | [
1,
1765
] | 2 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
8,
2,
2,
2,
4
] | 6 | true | Family | Zinc finger protein 318-like | Zinc finger protein 318-like | Znf318-like | 3 |
IPR055310 | 55,310 | Centrosomal protein of 112 kDa | CEP112 | Family | 2,175 | false | false | This family of proteins includes Centrosomal protein of 112 kDa which is thought to be involved in the organisation and function of the centrosome, a cellular structure critical for the organisation of microtubules and the segregation of chromosomes during cell division [ ]. Members of this family are known to play a r... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR18871"
] | [
""
] | [
2175
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00060832",
"PUB00155338",
"PUB00155339",
"PUB00155340"
] | [
"21399614",
"20417281",
"25115610",
"23456457"
] | [
"Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods.",
"Identification and characterisation of a Maf1/Macoco protein complex that interacts with GABAA receptors in neurons.",
"Mutations in microRNA binding sites of CEP genes involved in cancer.",
"CE... | [
2011,
2010,
2014,
2013
] | 4 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota"
] | [
10,
2165
] | 2 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
8,
15,
11,
11
] | 4 | true | Family | Centrosomal protein of 112 kDa | Centrosomal protein of 112 kDa | CEP112 | 6 |
IPR055311 | 55,311 | Phosphatidylcholine:diacylglycerol cholinephosphotransferase 1/2-like | PDCT1/2-like | Family | 836 | false | false | This entry represents a group of proteins predominantly found in plants, including phosphatidylcholine:diacylglycerol cholinephosphotransferase 1 (PDCT1 or ROD1) and 2 (PDCT2) from Arabidopsis thaliana. PDCT1 catalyses the transfer of the phosphocholine headgroup from phosphatidylcholine (PC) to diacylglycerol, a major... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR34674"
] | [
""
] | [
836
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00155341",
"PUB00155342",
"PUB00155343"
] | [
"19833868",
"22371508",
"22932756"
] | [
"An enzyme regulating triacylglycerol composition is encoded by the ROD1 gene of Arabidopsis.",
"The phosphatidylcholine diacylglycerol cholinephosphotransferase is required for efficient hydroxy fatty acid accumulation in transgenic Arabidopsis.",
"Acyl editing and headgroup exchange are the major mechanisms t... | [
2009,
2012,
2012
] | 3 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Pseudomonadati"
] | [
831,
5
] | 2 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
8,
3,
8
] | 3 | true | Family | Phosphatidylcholine:diacylglycerol cholinephosphotransferase 1/2-like | Phosphatidylcholine:diacylglycerol cholinephosphotransferase 1/2-like | PDCT1/2-like | 8 |
IPR055312 | 55,312 | F-box/LRR-repeat protein 15-like | FBL15-like | Family | 3,823 | false | false | This entry represents F-box/LRR-repeat protein 15 from Arabidopsis thaliana (FBL15) and similar plant proteins. Members of this family contain an F-box-like domain and LRR repeats. | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR34709"
] | [
""
] | [
3823
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
3823
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
4,
116,
63
] | 3 | true | Family | F-box/LRR-repeat protein 15-like | F-box/LRR-repeat protein 15-like | FBL15-like | 4 |
IPR055313 | 55,313 | Temptin-like | Temptin-like | Family | 1,210 | false | false | This entry represents Temptin from Aplysia californica and similar proteins from eukaryotes and bacteria. Temptin is a component of the complex of water-borne protein pheromones that stimulates attraction and mating behaviour. It modulates pheromone signalling by direct binding to attractin [ , ]. | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR34737"
] | [
""
] | [
1210
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00155344",
"PUB00155345"
] | [
"15054104",
"17894821"
] | [
"Characterization of Aplysia enticin and temptin, two novel water-borne protein pheromones that act in concert with attractin to stimulate mate attraction.",
"Aplysia temptin - the 'glue' in the water-borne attractin pheromone complex."
] | [
2004,
2007
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
8,
1200,
2
] | 3 | [] | [] | 0 | true | Family | Temptin-like | Temptin-like | Temptin-like | 7 |
IPR055314 | 55,314 | At2g29880-like | At2g29880-like | Family | 1,174 | false | false | This entry represents the uncharacterised protein At2g29880 from Arabidopsis thaliana and related plant proteins, found mainly in clade Magnoliopsida. Members of this family contain a Myb/SANT-like domain at the N terminus [ ]. Their function is unknown. | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR47864"
] | [
""
] | [
1174
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1174
] | 1 | [
"Arabidopsis thaliana"
] | [
26
] | 1 | true | Family | At2g29880-like | At2g29880-like | At2g29880-like | 4 |
IPR055315 | 55,315 | Cramped-like | Cramped-like | Family | 3,640 | false | false | This family of proteins includes cramped protein from Drosophila melanogaster and its orthologues from animals, cramped-like proteins. Cramped is involved in the regulation of gene expression patterns, particularly those governing developmental processes and segmental determination. They are associated with the Polycom... | [
"GO:0003682"
] | [
"chromatin binding"
] | [
"molecular_function"
] | 1 | [
"PANTHER"
] | [
"PTHR21677"
] | [
""
] | [
3640
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00155346"
] | [
"9310333"
] | [
"The cramped gene of Drosophila is a member of the Polycomb-group, and interacts with mus209, the gene encoding Proliferating Cell Nuclear Antigen."
] | [
1997
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
3640
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
11,
2,
2,
1,
5,
1,
14,
2,
33
] | 9 | true | Family | Cramped-like | Cramped-like | Cramped-like | 5 |
IPR055316 | 55,316 | Radial spoke head protein 9 homolog | RSP9 | Family | 1,898 | false | false | The Radial spoke head protein 9 homolog (RSPH9) is involved in the assembly and function of axonemal radial spoke complexes, which are crucial for the motility of sperm and cilia [ , , , ]. Members of this family are essential for radial spoke head assembly and central pair microtubule stability, impacting the motility... | [
"GO:0035082"
] | [
"axoneme assembly"
] | [
"biological_process"
] | 1 | [
"PANTHER"
] | [
"PTHR22069"
] | [
""
] | [
1898
] | 1 | [] | [] | [] | 0 | [
"7dmp",
"7jr9",
"7jrj",
"7jtk",
"8glv",
"8j07",
"8wzb",
"8x2u",
"9e5c",
"9fqr"
] | 10 | [
"PUB00092583",
"PUB00153060",
"PUB00155347",
"PUB00155348",
"PUB00155349"
] | [
"19200523",
"36417862",
"30383886",
"34871179",
"27687975"
] | [
"Mutations in radial spoke head protein genes RSPH9 and RSPH4A cause primary ciliary dyskinesia with central-microtubular-pair abnormalities.",
"Differential requirements of IQUB for the assembly of radial spoke 1 and the motility of mouse cilia and flagella.",
"Rsph9 is critical for ciliary radial spoke assemb... | [
2009,
2022,
2019,
2021,
2016
] | 5 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1898
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
1,
1,
3,
3
] | 5 | true | Family | Radial spoke head protein 9 homolog | Radial spoke head protein 9 homolog | RSP9 | 4 |
IPR055317 | 55,317 | CLAVATA3/ESR (CLE)-related protein 14-like | CLE14-like | Family | 411 | false | false | This entry represents CLAVATA3/ESR (CLE)-related protein 14 from Arabidopsis thaliana (CLE14) and similar proteins predominantly found in plants. CLE14 is an extracellular signal peptide that regulates cell fate. It represses root apical meristem maintenance and functions as an elicitor of the root meristem differentia... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR35472"
] | [
""
] | [
411
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00155350",
"PUB00155351"
] | [
"20697738",
"28586647"
] | [
"CLE14/CLE20 peptides may interact with CLAVATA2/CORYNE receptor-like kinases to irreversibly inhibit cell division in the root meristem of Arabidopsis.",
"Phosphate Starvation-Dependent Iron Mobilization Induces CLE14 Expression to Trigger Root Meristem Differentiation through CLV2/PEPR2 Signaling."
] | [
2010,
2017
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
411
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans"
] | [
2,
1
] | 2 | true | Family | CLAVATA3/ESR (CLE)-related protein 14-like | CLAVATA3/ESR (CLE)-related protein 14-like | CLE14-like | 9 |
IPR055319 | 55,319 | At5g58720-like | At5g58720-like | Family | 848 | false | false | This family represents the SMR domain-containing protein At5g58720 from Arabidopsis thaliana and related plant proteins, mainly from clade Magnoliopsida. Members of this family contain SMR domain which is typically involved in DNA repair processes and is found in a variety of proteins that participate in mismatch repai... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR47676"
] | [
""
] | [
848
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Streptophytina"
] | [
848
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
9,
3,
34
] | 3 | true | Family | At5g58720-like | At5g58720-like | At5g58720-like | 1 |
IPR055320 | 55,320 | Centrosomal protein of 72 kDa-like | CEP72-like | Family | 1,206 | false | false | This family of proteins includes centrosomal protein of 72 kDa (CEP72) which is involved in centrosomal and spindle assembly functions [ ]. CEP72 plays a crucial role in the recruitment of essential proteins to the centrosome, a key cellular structure involved in organising microtubules. They are responsible for provid... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR23311"
] | [
""
] | [
1206
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-2565942",
"R-HSA-380259",
"R-HSA-380270",
"R-HSA-380284",
"R-HSA-380320",
"R-HSA-5620912",
"R-HSA-8854518",
"R-MMU-2565942",
"R-MMU-380259",
"R-MMU-380270",
"R-MMU-380284",
"R-MMU-380320",
"R-MMU-5620912",
"R-MMU-8854518"
] | [
"REACTOME:R-HSA-2565942",
"REACTOME:R-HSA-380259",
"REACTOME:R-HSA-380270",
"REACTOME:R-HSA-380284",
"REACTOME:R-HSA-380320",
"REACTOME:R-HSA-5620912",
"REACTOME:R-HSA-8854518",
"REACTOME:R-MMU-2565942",
"REACTOME:R-MMU-380259",
"REACTOME:R-MMU-380270",
"REACTOME:R-MMU-380284",
"REACTOME:R-MMU... | 14 | [] | 0 | [
"PUB00061741",
"PUB00076882"
] | [
"19536135",
"26297806"
] | [
"Cep72 regulates the localization of key centrosomal proteins and proper bipolar spindle formation.",
"Centriolar satellites assemble centrosomal microcephaly proteins to recruit CDK2 and promote centriole duplication."
] | [
2009,
2015
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1206
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
5,
9,
9,
6
] | 4 | true | Family | Centrosomal protein of 72 kDa-like | Centrosomal protein of 72 kDa-like | CEP72-like | 5 |
IPR055322 | 55,322 | C3orf49-like | C3orf49-like | Family | 211 | false | false | This entry represents a group of proteins from vertebrates, including human Putative uncharacterized protein C3orf49. | [] | [] | [] | 0 | [
"PFAM",
"PANTHER"
] | [
"PF28264",
"PTHR36473"
] | [
"C3orf49",
""
] | [
211,
211
] | 2 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Vertebrata"
] | [
211
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
4,
2,
2
] | 3 | true | Family | C3orf49-like | C3orf49-like | C3orf49-like | 5 |
IPR055323 | 55,323 | Uncharacterized protein C57A10.07/YOR238W | C57A10.07/YOR238W | Family | 2,235 | false | false | This entry includes the uncharacterised proteins C57A10.07/YOR238W from S.pombe and S.cerevisiae, respectively, which are orthologues. Their function is not yet known. | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR28110"
] | [
""
] | [
2235
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Pseudomonadati",
"marine sediment metagenome"
] | [
2228,
5,
2
] | 3 | [
"Arabidopsis thaliana",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)",
"Zea mays"
] | [
3,
1,
3,
1,
1,
2
] | 6 | true | Family | Uncharacterized protein C57A10.07/YOR238W | Uncharacterized protein C57A10.07/YOR238W | C57A10.07/YOR238W | 2 |
IPR055325 | 55,325 | Cilia- and flagella-associated protein 161 | CF161 | Family | 1,764 | false | false | This entry represents human Cilia- and flagella-associated protein 161 (CF161) and similar proteins mainly found in animals. CF161 consists of microtubule inner proteins (MIPs) that are integral components of the dynein-decorated doublet microtubules (DMTs) in the axoneme of cilia [ ]. These proteins are essential for ... | [] | [] | [] | 0 | [
"PFAM",
"PANTHER"
] | [
"PF24569",
"PTHR24274"
] | [
"CFAP161",
""
] | [
1576,
1727
] | 2 | [] | [] | [] | 0 | [
"6u42",
"7rro",
"7ung",
"8g2z",
"8g3d",
"8glv",
"8i7r",
"8iyj",
"8j07",
"8otz",
"8sf7",
"8snb",
"8to0",
"9cpb",
"9cpc",
"9d5n",
"9e2g",
"9e5c",
"9e78",
"9fqr"
] | 20 | [
"PUB00103594",
"PUB00152767"
] | [
"36191189",
"37258679"
] | [
"SPACA9 is a lumenal protein of human ciliary singlet and doublet microtubules.",
"Axonemal structures reveal mechanoregulatory and disease mechanisms."
] | [
2022,
2023
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1764
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
2,
4,
4,
4
] | 5 | true | Family | Cilia- and flagella-associated protein 161 | Cilia- and flagella-associated protein 161 | CF161 | 3 |
IPR055326 | 55,326 | Transcriptional elongation regulator MINIYO | MINIYO | Family | 860 | false | false | This family includes Transcriptional elongation regulator MINIYO from Arabidopsis thaliana and related plant proteins. MINIYO acts as a positive regulator of transcriptional elongation, a crucial process in gene expression. Members of this family are essential for initiating cell differentiation by interacting with RNA... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR47605"
] | [
""
] | [
860
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00155353",
"PUB00155366",
"PUB00155367"
] | [
"21620701",
"31552063",
"38513608"
] | [
"A molecular switch for initiating cell differentiation in Arabidopsis.",
"Identification of Domains and Factors Involved in MINIYO Nuclear Import.",
"Arabidopsis ribosomal RNA processing meerling mutants exhibit suspensor-derived polyembryony due to direct reprogramming of the suspensor."
] | [
2011,
2019,
2024
] | 3 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
860
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
6,
5,
12
] | 3 | true | Family | Transcriptional elongation regulator MINIYO | Transcriptional elongation regulator MINIYO | MINIYO | 1 |
IPR055327 | 55,327 | TNF receptor-associated factor homolog 1a/b | TRAF1A/B | Family | 2,090 | false | false | This family represents TNF receptor-associated factor homolog 1a/b from Arabidopsis thaliana, which function redundantly and are involved in the regulation of plant immune responses and autophagy [ , ]. Members of this family contribute to the turnover of specific nucleotide-binding domain and leucine-rich repeat-conta... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR47477"
] | [
""
] | [
2090
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00155354",
"PUB00155355"
] | [
"26867179",
"28351989"
] | [
"Plant TRAF Proteins Regulate NLR Immune Receptor Turnover.",
"TRAF Family Proteins Regulate Autophagy Dynamics by Modulating AUTOPHAGY PROTEIN6 Stability in Arabidopsis."
] | [
2016,
2017
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
2090
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
28,
14,
89
] | 3 | true | Family | TNF receptor-associated factor homolog 1a/b | TNF receptor-associated factor homolog 1a/b | TRAF1A/B | 4 |
IPR055330 | 55,330 | Preprotein translocase subunit SECE1-like | SECE1-like | Family | 517 | false | false | This entry represents Preprotein translocase subunit SECE1 from Arabidopsis thaliana and similar plant proteins. SECE1 is involved in the import/insertion pathway in the thylakoids [ , ]. | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR37240"
] | [
""
] | [
517
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00099958",
"PUB00155358"
] | [
"21051552",
"11389897"
] | [
"Plastids contain a second sec translocase system with essential functions.",
"Complementation of bacterial SecE by a chloroplastic homologue."
] | [
2011,
2001
] | 2 | [] | [] | 0 | 0 | null | [
"Viridiplantae"
] | [
517
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
4,
4,
4
] | 3 | true | Family | Preprotein translocase subunit SECE1-like | Preprotein translocase subunit SECE1-like | SECE1-like | 6 |
IPR055331 | 55,331 | FMR1 neighbor protein-like | FMR1-like | Family | 237 | false | false | This entry represents human FMR1 neighbor protein (FMR1NB) and similar sequences mainly found in mammals. Members of this family are located in the vicinity of the FMR1 gene, which is associated with Fragile X syndrome, a condition related to intellectual disability and developmental delays. FMR1NB, also named NY-SAR-3... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR37360"
] | [
""
] | [
237
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00155359",
"PUB00155360"
] | [
"26648093",
"28126340"
] | [
"Cancer/testis antigen NY-SAR-35 enhances cell proliferation, migration, and invasion.",
"A cancer/testis antigen, NY-SAR-35, induces EpCAM, CD44, and CD133, and activates ERK in HEK293 cells."
] | [
2016,
2017
] | 2 | [] | [] | 0 | 0 | null | [
"Gnathostomata"
] | [
237
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
4,
3
] | 3 | true | Family | FMR1 neighbor protein-like | FMR1 neighbor protein-like | FMR1-like | 7 |
IPR055333 | 55,333 | Histone H2B, conserved site | HISTONE_H2B_site | Conserved_site | 16,279 | false | false | This entry represents a conserved region in the C-terminal part of H2B [ , ]. Histone H2B is one of the five histones, along with H1/H5, H2A, H3 and H4. Two copies of each of the H2A, H2B, H3, and H4 histones ensemble to form the core of the nucleosome [ ]. The nucleosome forms octameric structure that wraps DNA in a l... | [] | [] | [] | 0 | [
"PROSITE"
] | [
"PS00357"
] | [
"HISTONE_H2B"
] | [
16279
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-110330",
"R-BTA-110331",
"R-BTA-171306",
"R-BTA-201722",
"R-BTA-212300",
"R-BTA-2299718",
"R-BTA-2559580",
"R-BTA-2559582",
"R-BTA-2559586",
"R-BTA-3214815",
"R-BTA-3214847",
"R-BTA-427359",
"R-BTA-427413",
"R-BTA-5250924",
"R-BTA-5578749",
"R-BTA-5625886",
"R-BTA-5689880",
... | [
"REACTOME:R-BTA-110330",
"REACTOME:R-BTA-110331",
"REACTOME:R-BTA-171306",
"REACTOME:R-BTA-201722",
"REACTOME:R-BTA-212300",
"REACTOME:R-BTA-2299718",
"REACTOME:R-BTA-2559580",
"REACTOME:R-BTA-2559582",
"REACTOME:R-BTA-2559586",
"REACTOME:R-BTA-3214815",
"REACTOME:R-BTA-3214847",
"REACTOME:R-B... | 215 | [
"1aoi",
"1eqz",
"1f66",
"1hio",
"1hq3",
"1id3",
"1kx3",
"1kx4",
"1kx5",
"1m18",
"1m19",
"1m1a",
"1p34",
"1p3a",
"1p3b",
"1p3f",
"1p3g",
"1p3i",
"1p3k",
"1p3l",
"1p3m",
"1p3o",
"1p3p",
"1s32",
"1tzy",
"1u35",
"1zbb",
"1zla",
"2aro",
"2cv5",
"2f8n",
"2fj7"... | 956 | [
"PUB00004388",
"PUB00004448",
"PUB00066796"
] | [
"2041803",
"8121801",
"16472024"
] | [
"Histone and histone gene compilation and alignment update.",
"Phylogenetic analysis of the core histones H2A, H2B, H3, and H4.",
"Recognition and classification of histones using support vector machine."
] | [
1991,
1994,
2006
] | 3 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Pandoravirus"
] | [
3,
16268,
8
] | 3 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
34,
4,
21,
1,
22,
18,
1,
22,
27,
2,
1,
51
] | 12 | true | Conserved_site | Histone H2B, conserved site | Histone H2B, conserved site | HISTONE_H2B_site | 2 |
IPR055334 | 55,334 | Peroxisomal biogenesis factor 8-like | PEX8-like | Family | 1,650 | false | false | This entry represents Peroxisomal biogenesis factor 8 from Komagataella pastoris (PEX8) and similar fungal proteins. PEX8 is an essential component of the machinery required for the import of both PTS1 and PTS2 (and perhaps all) peroxisomal matrix proteins [ , ]. This family also includes the ortologue PEX17 from Yarro... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR39214"
] | [
""
] | [
1650
] | 1 | [] | [] | [] | 0 | [
"8rqt"
] | 1 | [
"PUB00155361",
"PUB00155362"
] | [
"23902771",
"7738036"
] | [
"Redox-regulated cargo binding and release by the peroxisomal targeting signal receptor, Pex5.",
"PER3, a gene required for peroxisome biogenesis in Pichia pastoris, encodes a peroxisomal membrane protein involved in protein import."
] | [
2013,
1995
] | 2 | [] | [] | 0 | 0 | null | [
"Fungi"
] | [
1650
] | 1 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)"
] | [
1
] | 1 | true | Family | Peroxisomal biogenesis factor 8-like | Peroxisomal biogenesis factor 8-like | PEX8-like | 5 |
IPR055335 | 55,335 | UBA domain-containing protein 6/RUP1 | Ucp6/RUP1 | Family | 1,586 | false | false | This entry represents the orthologues UBA domain-containing protein 6 from Schizosaccharomyces pombe (Ucp6), UBA domain-containing protein RUP1 from Saccharomyces cerevisiae and similar fungal proteins. Ucp6 modulates the activity of the RSP5 HECT ubiquitin-protein ligase through its mediation of the interaction betwee... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR39597"
] | [
""
] | [
1586
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00056710",
"PUB00056711"
] | [
"15933713",
"17028178"
] | [
"The Rsp5 ubiquitin ligase is coupled to and antagonized by the Ubp2 deubiquitinating enzyme.",
"The deubiquitinating enzyme Ubp2 modulates Rsp5-dependent Lys63-linked polyubiquitin conjugates in Saccharomyces cerevisiae."
] | [
2005,
2006
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1586
] | 1 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
1,
1,
1
] | 3 | true | Family | UBA domain-containing protein 6/RUP1 | UBA domain-containing protein 6/RUP1 | Ucp6/RUP1 | 9 |
IPR055336 | 55,336 | F-box protein At4g00755-like | At4g00755-like | Family | 1,848 | false | false | This entry represents F-box protein At4g00755 from Arabidopsis thaliana and similar proteins predominantly found in plants. Many members of this family contain the F-box domain. | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR39741"
] | [
""
] | [
1848
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1848
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
3,
9,
6
] | 3 | true | Family | F-box protein At4g00755-like | F-box protein At4g00755-like | At4g00755-like | 8 |
IPR055338 | 55,338 | YqfX-like | YqfX-like | Family | 2,604 | false | false | This entry represents a group of uncharacterised proteins, including YqfX from Bacillus subtilis ( ). The function of these proteins is unknown but the presence of predicted transmembrane helices suggests that they are likely associated with membrane. | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR40040"
] | [
""
] | [
2604
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Methanoculleus methanifontis",
"marine sediment metagenome"
] | [
2602,
1,
1
] | 3 | [] | [] | 0 | true | Family | YqfX-like | YqfX-like | YqfX-like | 8 |
IPR055339 | 55,339 | WD repeat and HMG-box DNA-binding protein 1, HMG-box | HMG-box_WDHD1 | Domain | 1,282 | false | false | This entry represents the HMG-box found at the C-terminal of WDHD1, which binds DNA [ ]. WDHD1, also called acidic nucleoplasmic DNA-binding protein 1 (AND-1), acts as a replication initiation factor that brings together the MCM2-7 helicase and the DNA polymerase alpha/primase complex in order to initiate DNA replicati... | [
"GO:0003677",
"GO:0006261"
] | [
"DNA binding",
"DNA-templated DNA replication"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PFAM",
"CDD"
] | [
"PF24815",
"cd21993"
] | [
"HMG_WDHD1",
"HMG-box_WDHD1"
] | [
1230,
1274
] | 2 | [] | [] | [] | 0 | [
"2d7l",
"6xty",
"7pfo",
"7plo",
"8b9d"
] | 5 | [
"PUB00062305",
"PUB00118339",
"PUB00148740",
"PUB00151993",
"PUB00154917"
] | [
"22570476",
"17761813",
"19805216",
"28381552",
"34694004"
] | [
"Okazaki fragment processing-independent role for human Dna2 enzyme during DNA replication.",
"Mcm10 and And-1/CTF4 recruit DNA polymerase alpha to chromatin for initiation of DNA replication.",
"Assembly of the Cdc45-Mcm2-7-GINS complex in human cells requires the Ctf4/And-1, RecQL4, and Mcm10 proteins.",
"T... | [
2012,
2007,
2009,
2017,
2021
] | 5 | [
"IPR009071"
] | [] | 1 | 0 | 1 | [
"Eukaryota"
] | [
1282
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
5,
4,
4
] | 4 | true | Domain | WD repeat and HMG-box DNA-binding protein 1, HMG-box | WD repeat and HMG-box DNA-binding protein 1, HMG-box | HMG-box_WDHD1 | 9 |
IPR055340 | 55,340 | Pre-mRNA-processing factor 19, U-box domain | RING-Ubox_PRP19 | Domain | 4,439 | false | false | This entry represents the U-box domain of Prp19. Prp19, also known as DNA repair protein Pso4 (psoralen-sensitive mutant 4), is a ubiquitously expressed multifunctional E3 ubiquitin ligase with pleiotropic activities in DNA damage signalling, repair, and replicative senescence. It functions as a critical component of D... | [] | [] | [] | 0 | [
"CDD"
] | [
"cd16656"
] | [
"RING-Ubox_PRP19"
] | [
4439
] | 1 | [
"EC",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"... | [
"2.3.2.27",
"PWY-7511",
"R-BTA-6781823",
"R-BTA-6782135",
"R-BTA-6782210",
"R-BTA-72163",
"R-CEL-6781823",
"R-CEL-6782135",
"R-CEL-6782210",
"R-CEL-72163",
"R-DDI-6781823",
"R-DDI-6782135",
"R-DDI-6782210",
"R-DDI-72163",
"R-HSA-6781823",
"R-HSA-6781827",
"R-HSA-6782135",
"R-HSA-67... | [
"EC:2.3.2.27",
"METACYC:PWY-7511",
"REACTOME:R-BTA-6781823",
"REACTOME:R-BTA-6782135",
"REACTOME:R-BTA-6782210",
"REACTOME:R-BTA-72163",
"REACTOME:R-CEL-6781823",
"REACTOME:R-CEL-6782135",
"REACTOME:R-CEL-6782210",
"REACTOME:R-CEL-72163",
"REACTOME:R-DDI-6781823",
"REACTOME:R-DDI-6782135",
"... | 34 | [
"1n87",
"2bay",
"3jb9",
"5gm6",
"5gmk",
"5lj5",
"5m88",
"5mq0",
"5mqf",
"5wsg",
"5xjc",
"5y88",
"5ylz",
"5yzg",
"5z56",
"5z57",
"6bk8",
"6exn",
"6ff7",
"6icz",
"6id0",
"6id1",
"6j6g",
"6j6h",
"6j6n",
"6j6q",
"6qdv",
"7a5p",
"7b9v",
"7dco",
"7w59",
"7w5a"... | 50 | [
"PUB00027592",
"PUB00033314",
"PUB00039586",
"PUB00067554",
"PUB00078520",
"PUB00090460",
"PUB00092514",
"PUB00137580",
"PUB00137581",
"PUB00137582",
"PUB00137583",
"PUB00155379"
] | [
"12627222",
"16332694",
"16388587",
"20595234",
"24332808",
"17981804",
"28502770",
"21536736",
"26292707",
"26364595",
"26130721",
"28962858"
] | [
"Structural insights into the U-box, a domain associated with multi-ubiquitination.",
"SNEV is an evolutionarily conserved splicing factor whose oligomerization is necessary for spliceosome assembly.",
"The Prp19 U-box crystal structure suggests a common dimeric architecture for a class of oligomeric E3 ubiquit... | [
2003,
2005,
2006,
2010,
2014,
2008,
2017,
2011,
2015,
2016,
2015,
2017
] | 12 | [
"IPR003613"
] | [] | 1 | 0 | 1 | [
"Eukaryota"
] | [
4439
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
9,
1,
1,
1,
2,
1,
1,
1,
9,
1,
1,
19
] | 12 | true | Domain | Pre-mRNA-processing factor 19, U-box domain | Pre-mRNA-processing factor 19, U-box domain | RING-Ubox_PRP19 | 5 |
IPR055341 | 55,341 | Herpesvirus glycoprotein B ectodomain C-terminal | Glycoprotein_B_ecto_C | Domain | 2,815 | false | false | This domain corresponds to the C-terminal region of the glycoprotein B ectodomain [ , , ]. gB ectodomain has an elongated rod-like molecule, composed of five domains that contain both β-sheet and α-helical secondary structures. Domains 1 and 2 have a fold that resembles that of a plekstrin-homology (PH) domains. Domain... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF00606"
] | [
"Glycoprotein_B"
] | [
2815
] | 1 | [
"REACTOME",
"REACTOME"
] | [
"R-HSA-9609690",
"R-HSA-9610379"
] | [
"REACTOME:R-HSA-9609690",
"REACTOME:R-HSA-9610379"
] | 2 | [
"2gum",
"3fvc",
"3nw8",
"3nwa",
"3nwd",
"3nwf",
"4bom",
"4hsi",
"4l1r",
"5c6t",
"5cxf",
"5v2s",
"5ys2",
"5ys6",
"5zs0",
"6bm8",
"6esc",
"6vlk",
"6vn1",
"6z9m",
"7fbi",
"7k1s",
"7kdd",
"7kdp",
"7uhz",
"7ui0",
"7yrn",
"8kfa",
"8rgz",
"8rh0",
"8rh1",
"8rh2"... | 56 | [
"PUB00041186",
"PUB00052055",
"PUB00085345",
"PUB00085346",
"PUB00155380"
] | [
"16840698",
"19196955",
"23736286",
"27573107",
"26365435"
] | [
"Crystal structure of glycoprotein B from herpes simplex virus 1.",
"Structure of a trimeric variant of the Epstein-Barr virus glycoprotein B.",
"Human cytomegalovirus (HCMV) glycoprotein gB promotes virus entry in trans acting as the viral fusion protein rather than as a receptor-binding protein.",
"Platelet... | [
2006,
2009,
2013,
2016,
2015
] | 5 | [] | [] | 0 | 0 | null | [
"Herpesvirales",
"Homo sapiens",
"Salmonella enterica"
] | [
2813,
1,
1
] | 3 | [
"Homo sapiens"
] | [
1
] | 1 | true | Domain | Herpesvirus glycoprotein B ectodomain C-terminal | Herpesvirus glycoprotein B ectodomain C-terminal | Glycoprotein_B_ecto_C | 9 |
IPR055342 | 55,342 | Rod shape-determining protein MreC, beta-barrel core | MreC_beta-barrel_core | Domain | 20,764 | false | false | This entry represents the periplasmic core of MreC and related proteins which is composed of two six-stranded β-barrels [ , ]. MreC self-associates into polar filaments [ ]. The periplasmic part of MreC contains also a coiled-coil which is involved in the formation of dimer essential for its function [ ]. MreC (murein ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF04085"
] | [
"MreC"
] | [
20764
] | 1 | [] | [] | [] | 0 | [
"2j5u",
"2qf4",
"2qf5",
"5lp5",
"6zlv",
"6zm0",
"7eft",
"9dvb",
"9dvc"
] | 9 | [
"PUB00048981",
"PUB00056833",
"PUB00155381",
"PUB00155984"
] | [
"17707860",
"2687239",
"34016967",
"34510818"
] | [
"High-resolution structure of the major periplasmic domain from the cell shape-determining filament MreC.",
"New mre genes mreC and mreD, responsible for formation of the rod shape of Escherichia coli cells.",
"Self-association of MreC as a regulatory signal in bacterial cell wall elongation.",
"The crystal s... | [
2007,
1989,
2021,
2022
] | 4 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
20182,
30,
552
] | 3 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Domain | Rod shape-determining protein MreC, beta-barrel core | Rod shape-determining protein MreC, beta-barrel core | MreC_beta-barrel_core | 3 |
IPR055345 | 55,345 | Large ribosomal subunit protein eL24-like, archaea | Ribosomal_eL24-like_arc | Family | 1,095 | false | false | This entry represents mammalian Large ribosomal subunit protein eL24 and related proteins from archaea. Ribosomal protein eL24/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (eL24, distinct from archaeal L24). eL24/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3,... | [
"GO:0003735"
] | [
"structural constituent of ribosome"
] | [
"molecular_function"
] | 1 | [
"HAMAP",
"NCBIFAM"
] | [
"MF_00773",
"NF034186"
] | [
"Ribosomal_eL24",
"PRK14891.1-1"
] | [
1018,
918
] | 2 | [] | [] | [] | 0 | [
"1ffk",
"1jj2",
"1k73",
"1k8a",
"1k9m",
"1kc8",
"1kd1",
"1kqs",
"1m1k",
"1m90",
"1ml5",
"1n8r",
"1nji",
"1q7y",
"1q81",
"1q82",
"1q86",
"1qvf",
"1qvg",
"1s72",
"1vq4",
"1vq5",
"1vq6",
"1vq7",
"1vq8",
"1vq9",
"1vqk",
"1vql",
"1vqm",
"1vqn",
"1vqo",
"1vqp"... | 137 | [
"PUB00007068",
"PUB00007069",
"PUB00007070",
"PUB00080482",
"PUB00080483",
"PUB00080484"
] | [
"11297922",
"11290319",
"11114498",
"15289434",
"17462931",
"15270688"
] | [
"Atomic structures at last: the ribosome in 2000.",
"The ribosome in focus.",
"The end of the beginning: structural studies of ribosomal proteins.",
"Ribosomal protein L24 defect in belly spot and tail (Bst), a mouse Minute.",
"Ribosomal protein L24 is differentially expressed in ovary and testis of the mar... | [
2001,
2001,
2000,
2004,
2007,
2004
] | 6 | [
"IPR056366"
] | [] | 1 | 0 | 1 | [
"Archaea",
"Eukaryota",
"ecological metagenomes"
] | [
866,
214,
15
] | 3 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
4,
3,
3
] | 3 | true | Family | Large ribosomal subunit protein eL24-like, archaea | Large ribosomal subunit protein eL24-like, archaea | Ribosomal_eL24-like_arc | 3 |
IPR055346 | 55,346 | SUF system FeS cluster assembly, SufBD | Fe-S_cluster_assembly_SufBD | Family | 43,535 | false | false | Iron-sulphur (FeS) clusters are important cofactors for numerous proteins involved in electron transfer, in redox and non-redox catalysis, in gene regulation, and as sensors of oxygen and iron. These functions depend on the various FeS cluster prosthetic groups, the most common being [2Fe-2S] and [4Fe-4S] [ ]. FeS clus... | [
"GO:0016226"
] | [
"iron-sulfur cluster assembly"
] | [
"biological_process"
] | 1 | [
"PANTHER",
"PANTHER"
] | [
"PTHR30508",
"PTHR43575"
] | [
"",
""
] | [
25829,
17706
] | 2 | [] | [] | [] | 0 | [
"1vh4",
"2zu0",
"4dn7",
"5awf",
"5awg",
"9h78",
"9h7y",
"9hbl"
] | 8 | [
"PUB00035635",
"PUB00035639",
"PUB00035640",
"PUB00089442",
"PUB00089443",
"PUB00089444"
] | [
"16221578",
"17350000",
"15278785",
"17350958",
"20857974",
"26472926"
] | [
"How Escherichia coli and Saccharomyces cerevisiae build Fe/S proteins.",
"The SUF iron-sulfur cluster biosynthetic machinery: sulfur transfer from the SUFS-SUFE complex to SUFA.",
"SufA/IscA: reactivity studies of a class of scaffold proteins involved in [Fe-S] cluster assembly.",
"SufE transfers sulfur from... | [
2005,
2007,
2004,
2007,
2010,
2015
] | 6 | [] | [
"IPR010231",
"IPR011542"
] | 0 | 2 | 0 | [
"Archaea",
"Bacteria",
"Caudoviricetes",
"Eukaryota",
"unclassified sequences"
] | [
1668,
38188,
2,
2627,
1050
] | 5 | [
"Arabidopsis thaliana",
"Escherichia coli (strain K12)",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
13,
2,
5,
10
] | 4 | true | Family | SUF system FeS cluster assembly, SufBD | SUF system FeS cluster assembly, SufBD | Fe-S_cluster_assembly_SufBD | 9 |
IPR055347 | 55,347 | U3 small nucleolar RNA-associated protein 6, N-terminal | UTP6_N | Domain | 4,550 | false | false | This entry represents the N-terminal segment of UTP6 proteins. This region contains repeats related to TPR superfamily repeats . Utp6 is a component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF08640"
] | [
"U3_assoc_6"
] | [
4550
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-DDI-6791226",
"R-HSA-6790901",
"R-HSA-6791226",
"R-MMU-6791226",
"R-SCE-6791226",
"R-SPO-6791226"
] | [
"REACTOME:R-DDI-6791226",
"REACTOME:R-HSA-6790901",
"REACTOME:R-HSA-6791226",
"REACTOME:R-MMU-6791226",
"REACTOME:R-SCE-6791226",
"REACTOME:R-SPO-6791226"
] | 6 | [
"5oql",
"5wlc",
"6ke6",
"6lqp",
"6lqq",
"6lqr",
"6lqs",
"6lqt",
"6lqu",
"6lqv",
"6nd4",
"6rxt",
"6rxu",
"6rxv",
"6rxx",
"6rxy",
"6rxz",
"6zqa",
"6zqb",
"6zqc",
"6zqd",
"7ajt",
"7aju",
"7d4i",
"7d5s",
"7d5t",
"7d63",
"7mq8",
"7mq9",
"7mqa",
"7suk",
"9g33"... | 43 | [
"PUB00008496"
] | [
"12068309"
] | [
"A large nucleolar U3 ribonucleoprotein required for 18S ribosomal RNA biogenesis."
] | [
2002
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
4550
] | 1 | [
"Arabidopsis thaliana",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"... | [
4,
3,
1,
4,
1,
1,
3,
4,
1,
1,
3
] | 11 | true | Domain | U3 small nucleolar RNA-associated protein 6, N-terminal | U3 small nucleolar RNA-associated protein 6, N-terminal | UTP6_N | 8 |
IPR055348 | 55,348 | Tripartite ATP-independent periplasmic transporters, DctQ component | DctQ | Domain | 51,727 | false | false | This entry includes tripartite ATP-independent periplasmic (TRAP) transporters which are substrate-binding protein (SBP)-dependent secondary transporters ubiquitous prokaryotes [ ]. They are comprised of an SBP of the DctP or TAXI families and two integral membrane proteins of unequal sizes that form the DctQ and DctM ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF04290"
] | [
"DctQ"
] | [
51727
] | 1 | [] | [] | [] | 0 | [
"7qe5",
"7qha",
"8b01",
"8thi",
"8thj",
"8y4w",
"8y4x",
"9pym"
] | 8 | [
"PUB00009932",
"PUB00015015",
"PUB00044822",
"PUB00078592"
] | [
"10627041",
"11524131",
"16262798",
"20584082"
] | [
"TRAP transporters: an ancient family of extracytoplasmic solute-receptor-dependent secondary active transporters.",
"The tripartite ATP-independent periplasmic (TRAP) transporters of bacteria and archaea.",
"Sialic acid transport in Haemophilus influenzae is essential for lipopolysaccharide sialylation and ser... | [
1999,
2001,
2005,
2011
] | 4 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Sym plasmid",
"unclassified sequences"
] | [
112,
50656,
32,
1,
926
] | 5 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Domain | Tripartite ATP-independent periplasmic transporters, DctQ component | Tripartite ATP-independent periplasmic transporters, DctQ component | DctQ | 6 |
IPR055349 | 55,349 | GIPC, GH2 | GH2_GIPC | Domain | 2,827 | false | false | The GIPC family includes PDZ domain-containing proteins, GIPC1 (also called GAIP C-terminus-interacting protein, RGS-GAIP-interacting protein, RGS19-interacting protein 1, RGS19IP1, synectin, tax interaction protein 2, or TIP-2), GIPC2, and GIPC3, which may act as scaffold proteins linking heterotrimeric G-proteins to ... | [] | [] | [] | 0 | [
"PFAM",
"CDD"
] | [
"PF25082",
"cd21180"
] | [
"GIPC1_GH2",
"GH2_GIPC"
] | [
2827,
2467
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-190370",
"R-HSA-190373",
"R-HSA-9839389",
"R-HSA-9839397",
"R-MMU-190370",
"R-MMU-190373",
"R-MMU-9839389",
"R-MMU-9839397",
"R-RNO-190370",
"R-RNO-190373",
"R-RNO-9839389",
"R-RNO-9839397"
] | [
"REACTOME:R-HSA-190370",
"REACTOME:R-HSA-190373",
"REACTOME:R-HSA-9839389",
"REACTOME:R-HSA-9839397",
"REACTOME:R-MMU-190370",
"REACTOME:R-MMU-190373",
"REACTOME:R-MMU-9839389",
"REACTOME:R-MMU-9839397",
"REACTOME:R-RNO-190370",
"REACTOME:R-RNO-190373",
"REACTOME:R-RNO-9839389",
"REACTOME:R-RN... | 12 | [
"5v6b",
"5v6e",
"5v6h",
"5v6t",
"7nrn"
] | 5 | [
"PUB00147338",
"PUB00147342",
"PUB00147343",
"PUB00147345",
"PUB00147348",
"PUB00147349"
] | [
"17881731",
"26757732",
"20634288",
"22991442",
"11836571",
"28537552"
] | [
"Myosin VI is required for targeted membrane transport during cytokinesis.",
"CAPG and GIPC1: Breast Cancer Biomarkers for Bone Metastasis Development and Treatment.",
"GIPC1 interacts with MyoGEF and promotes MDA-MB-231 breast cancer cell invasion.",
"Gipc1 has a dual role in Vangl2 trafficking and hair bund... | [
2007,
2016,
2010,
2012,
2002,
2017
] | 6 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
2827
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
6,
1,
7,
3,
8
] | 6 | true | Domain | GIPC, GH2 | GIPC, GH2 | GH2_GIPC | 3 |
IPR055350 | 55,350 | Coiled-coil protein 142, C-terminal | CCDC142_C | Domain | 1,283 | false | false | This entry represents an α-helical ARM segment found at the C-terminal of CC142 proteins, whose function is unknown. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF14923"
] | [
"CCDC142"
] | [
1283
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"bird metagenome"
] | [
1282,
1
] | 2 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
2,
2,
1,
2
] | 5 | true | Domain | Coiled-coil protein 142, C-terminal | Coiled-coil protein 142, C-terminal | CCDC142_C | 2 |
IPR055352 | 55,352 | aECM cysteine-cradle domain | CCD_aECM | Domain | 464 | false | false | This domain is found in nematode proteins that are known to be aECM (apical ExtraCellular Matrice) components. It is predicted to adopt a globular α-helical structure with a cradle-like shape. This domain contains four invariant cysteines which are probably involved in forming two disulfide bonds. The latter likely con... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23626"
] | [
"CCD_aECM"
] | [
464
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Chromadorea"
] | [
464
] | 1 | [
"Caenorhabditis elegans"
] | [
7
] | 1 | true | Domain | aECM cysteine-cradle domain | aECM cysteine-cradle domain | CCD_aECM | 1 |
IPR055353 | 55,353 | Domain of unknown function DUF7619 | DUF7619 | Domain | 1,864 | false | false | This domain is found in uncharacterised proteins, sometimes in multiple copies. Some proteins containing this domain contain either LPXTG cell wall anchor motif or secretion system C-terminal sorting domain at the C terminus. It is likely that some members of this entry contain an intramolecular isopeptide bond. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24595"
] | [
"DUF7619"
] | [
1864
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"ecological metagenomes"
] | [
4,
1827,
29,
4
] | 4 | [] | [] | 0 | true | Domain | Domain of unknown function DUF7619 | Domain of unknown function DUF7619 | DUF7619 | 9 |
IPR055354 | 55,354 | Domain of unknown function DUF7507 | DUF7507 | Domain | 3,876 | false | false | This domain of unknown function is found in multiple copies in a number of bacterial proteins. It is closely related to domains represented by DUF11 ( ). Similarly to DUF11, this domain contains a conserved N-terminal lysine and a C-terminal asparagine with central aspartate/glutamate residues suggesting that it may co... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24346"
] | [
"DUF7507"
] | [
3876
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
174,
3626,
26,
50
] | 4 | [] | [] | 0 | true | Domain | Domain of unknown function DUF7507 | Domain of unknown function DUF7507 | DUF7507 | 7 |
IPR055355 | 55,355 | ZP-C domain | ZP-C | Domain | 29,724 | false | false | This entry represents the ZP-C domain which is the C-terminal structural domain that composes the Zona pellucida domain. This domain is predicted to adopt an Ig-like β-sandwich topology. The zona pellucida (ZP) domain is a protein polymerisation module of ~260 amino acid module, which is found at the C terminus of many... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF00100"
] | [
"Zona_pellucida"
] | [
29724
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-2534343",
"R-HSA-1502540",
"R-HSA-163125",
"R-HSA-190370",
"R-HSA-190373",
"R-HSA-201451",
"R-HSA-2173789",
"R-HSA-2534343",
"R-HSA-446203",
"R-HSA-5683826",
"R-HSA-9839383",
"R-HSA-9839389",
"R-HSA-9839394",
"R-HSA-9839397",
"R-HSA-9839406",
"R-HSA-9925561",
"R-MMU-1502540",
... | [
"REACTOME:R-BTA-2534343",
"REACTOME:R-HSA-1502540",
"REACTOME:R-HSA-163125",
"REACTOME:R-HSA-190370",
"REACTOME:R-HSA-190373",
"REACTOME:R-HSA-201451",
"REACTOME:R-HSA-2173789",
"REACTOME:R-HSA-2534343",
"REACTOME:R-HSA-446203",
"REACTOME:R-HSA-5683826",
"REACTOME:R-HSA-9839383",
"REACTOME:R-H... | 41 | [
"3nk3",
"3nk4",
"3qw9",
"4ajv",
"4wrn",
"5bup",
"6tqk",
"6tql",
"6zs5",
"6zya",
"7lbg",
"7pfp",
"7q3n",
"8bqu",
"8dc0",
"8rki",
"8xc5",
"9nu1",
"9nu2",
"9nu3"
] | 20 | [
"PUB00001633",
"PUB00017980",
"PUB00017982",
"PUB00017983",
"PUB00054244",
"PUB00155598",
"PUB00155942",
"PUB00155943",
"PUB00155944",
"PUB00158837",
"PUB00163198"
] | [
"1313375",
"12021773",
"12878193",
"15079052",
"20970175",
"33196145",
"21402931",
"23826237",
"26811476",
"21715714",
"40550004"
] | [
"A large domain common to sperm receptors (Zp2 and Zp3) and TGF-beta type III receptor.",
"The ZP domain is a conserved module for polymerization of extracellular proteins.",
"Identification of the carboxyl termini of porcine zona pellucida glycoproteins ZPB and ZPC.",
"A duplicated motif controls assembly of... | [
1992,
2002,
2003,
2004,
2010,
2020,
2011,
2013,
2016,
2011,
2025
] | 11 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
29724
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
7,
152,
8,
40,
40,
65
] | 6 | true | Domain | ZP-C domain | ZP-C domain | ZP-C | 4 |
IPR055356 | 55,356 | ZP-N domain | ZP-N | Domain | 21,484 | false | false | This entry represents the ZP-N domain which is the N-terminal structural domain of the Zona pellucida domain. This domain is predicted to adopt an Ig-like β-sandwich topology. The zona pellucida (ZP) domain is a protein polymerisation module of ~260 amino acid module, which is found at the C terminus of many secreted e... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23344"
] | [
"ZP-N"
] | [
21484
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-2534343",
"R-HSA-1502540",
"R-HSA-163125",
"R-HSA-190370",
"R-HSA-190373",
"R-HSA-201451",
"R-HSA-2173789",
"R-HSA-2534343",
"R-HSA-446203",
"R-HSA-5683826",
"R-HSA-9839383",
"R-HSA-9839389",
"R-HSA-9839394",
"R-HSA-9839397",
"R-HSA-9839406",
"R-HSA-9925561",
"R-MMU-1502540",
... | [
"REACTOME:R-BTA-2534343",
"REACTOME:R-HSA-1502540",
"REACTOME:R-HSA-163125",
"REACTOME:R-HSA-190370",
"REACTOME:R-HSA-190373",
"REACTOME:R-HSA-201451",
"REACTOME:R-HSA-2173789",
"REACTOME:R-HSA-2534343",
"REACTOME:R-HSA-446203",
"REACTOME:R-HSA-5683826",
"REACTOME:R-HSA-9839383",
"REACTOME:R-H... | 39 | [
"3d4c",
"3d4g",
"3ef7",
"3nk3",
"3nk4",
"4wrn",
"5osq",
"6tqk",
"6tql",
"6zs5",
"6zya",
"7lbg",
"7pfp",
"7q3n",
"8bqu",
"8rki",
"8xc5",
"9nu1",
"9nu2",
"9nu3"
] | 20 | [
"PUB00001633",
"PUB00017980",
"PUB00017982",
"PUB00017983",
"PUB00051238",
"PUB00054244",
"PUB00155598",
"PUB00155599",
"PUB00155944",
"PUB00163198"
] | [
"1313375",
"12021773",
"12878193",
"15079052",
"19052627",
"20970175",
"33196145",
"32815518",
"26811476",
"40550004"
] | [
"A large domain common to sperm receptors (Zp2 and Zp3) and TGF-beta type III receptor.",
"The ZP domain is a conserved module for polymerization of extracellular proteins.",
"Identification of the carboxyl termini of porcine zona pellucida glycoproteins ZPB and ZPC.",
"A duplicated motif controls assembly of... | [
1992,
2002,
2003,
2004,
2008,
2010,
2020,
2020,
2016,
2025
] | 10 | [] | [] | 0 | 0 | null | [
"Eumetazoa"
] | [
21484
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
86,
28,
34,
60
] | 4 | true | Domain | ZP-N domain | ZP-N domain | ZP-N | 7 |
IPR055357 | 55,357 | At1g61320/AtMIF1, LRR domain | LRR_At1g61320_AtMIF1 | Domain | 16,487 | false | false | This entry represents the leucine-rich repeats (LRR) mainly found in plant proteins, such as At1g61320 and At1g61330 from Arabidopsis thaliana, which are F-box/LRR-repeat containing proteins involved in the ubiquitin-proteasome pathway. They function as components of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase co... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23622"
] | [
"LRR_At1g61320_AtMIF1"
] | [
16487
] | 1 | [] | [] | [] | 0 | [
"8yn1"
] | 1 | [
"PUB00096545",
"PUB00153716"
] | [
"23166809",
"33098089"
] | [
"A comprehensive analysis of interaction and localization of Arabidopsis SKP1-like (ASK) and F-box (FBX) proteins.",
"AtMIF1 increases seed oil content by attenuating GL2 inhibition."
] | [
2012,
2021
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"marine sediment metagenome"
] | [
15,
16471,
1
] | 3 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
52,
298,
68
] | 3 | true | Domain | At1g61320/AtMIF1, LRR domain | At1g61320/AtMIF1, LRR domain | LRR_At1g61320_AtMIF1 | 4 |
IPR055358 | 55,358 | Clathrin heavy-chain repeat | CHCR | Repeat | 11,213 | false | false | This entry represents the CHCR found in the arm region of the Clathrin heavy chain. Clathrin is a triskelion-shaped cytoplasmic protein that polymerises into a polyhedral lattice on intracellular membranes to form protein-coated membrane vesicles. Lattice formation induces the sorting of membrane proteins during endocy... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF00637"
] | [
"Clathrin"
] | [
11213
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-177504",
"R-BTA-190873",
"R-BTA-196025",
"R-BTA-2132295",
"R-BTA-432720",
"R-BTA-432722",
"R-BTA-437239",
"R-BTA-5099900",
"R-BTA-5140745",
"R-BTA-8856825",
"R-BTA-8856828",
"R-BTA-8866427",
"R-BTA-8964038",
"R-BTA-9013420",
"R-BTA-9013424",
"R-CEL-190873",
"R-CEL-196025",
"... | [
"REACTOME:R-BTA-177504",
"REACTOME:R-BTA-190873",
"REACTOME:R-BTA-196025",
"REACTOME:R-BTA-2132295",
"REACTOME:R-BTA-432720",
"REACTOME:R-BTA-432722",
"REACTOME:R-BTA-437239",
"REACTOME:R-BTA-5099900",
"REACTOME:R-BTA-5140745",
"REACTOME:R-BTA-8856825",
"REACTOME:R-BTA-8856828",
"REACTOME:R-BT... | 114 | [
"1b89",
"1xi4",
"1xi5",
"3iyv",
"3lvg",
"3lvh",
"3qil",
"6sct",
"6wcj",
"6yai"
] | 10 | [
"PUB00000871",
"PUB00004649",
"PUB00023546",
"PUB00068728",
"PUB00068729",
"PUB00068730",
"PUB00068731",
"PUB00160303"
] | [
"1547490",
"3480512",
"10360576",
"11160821",
"12906858",
"11448994",
"17702618",
"21330665"
] | [
"Folding and trimerization of clathrin subunits at the triskelion hub.",
"Clathrin heavy chain: molecular cloning and complete primary structure.",
"Clathrin self-assembly is mediated by a tandemly repeated superhelix.",
"Vps41p function in the alkaline phosphatase pathway requires homo-oligomerization and in... | [
1992,
1987,
1999,
2001,
2003,
2001,
2007,
2011
] | 8 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Ignavibacterium album (strain DSM 19864 / JCM 16511 / NBRC 101810 / Mat9-16)"
] | [
11212,
1
] | 2 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
6,
1,
9,
3,
26,
7,
1,
14,
8,
1,
1,
222
] | 12 | true | Repeat | Clathrin heavy-chain repeat | Clathrin heavy-chain repeat | CHCR | 9 |
IPR055359 | 55,359 | 60S ribosome subunit biogenesis protein Nip7, pre-PUA domain, eukaryotes | Nip7_N_euk | Domain | 4,293 | false | false | Human 60S ribosome subunit biogenesis protein NIP7 homologue (also known as KD93) is essential in the accurate processing of pre-rRNA [ ]. The overall fold of KD93 consists of two interlinked α/β domains. The C-terminal domain resembles the PUA domain of some RNA modification enzymes, especially that of archaeosine tRN... | [] | [] | [] | 0 | [
"CDD"
] | [
"cd21146"
] | [
"Nip7_N_euk"
] | [
4293
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-6791226",
"R-MMU-6791226",
"R-RNO-6791226",
"R-SSC-6791226"
] | [
"REACTOME:R-HSA-6791226",
"REACTOME:R-MMU-6791226",
"REACTOME:R-RNO-6791226",
"REACTOME:R-SSC-6791226"
] | 4 | [
"1sqw",
"1t5y",
"6elz",
"6em5",
"7nac",
"7ohr",
"7r6k",
"7r7a",
"7r7c",
"8esq",
"8esr",
"8fkt",
"8fku",
"8fkv",
"8fkw",
"8fkx",
"8fky",
"8i9r",
"8i9t",
"8i9v",
"8i9w",
"8i9x",
"8i9y",
"8i9z",
"8ia0",
"8v83",
"8v84",
"8v87"
] | 28 | [
"PUB00017206",
"PUB00031177",
"PUB00068805",
"PUB00100535",
"PUB00102150"
] | [
"9271378",
"15522784",
"22195017",
"29245012",
"20798176"
] | [
"Saccharomyces cerevisiae Nip7p is required for efficient 60S ribosome subunit biogenesis.",
"Crystal structure of KD93, a novel protein expressed in human hematopoietic stem/progenitor cells.",
"The human nucleolar protein FTSJ3 associates with NIP7 and functions in pre-rRNA processing.",
"Visualizing the As... | [
1997,
2004,
2011,
2017,
2011
] | 5 | [
"IPR040598"
] | [] | 1 | 0 | 1 | [
"Eukaryota"
] | [
4293
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
3,
1,
2,
1,
3,
2,
1,
3,
2,
1,
1,
2
] | 12 | true | Domain | 60S ribosome subunit biogenesis protein Nip7, pre-PUA domain, eukaryotes | 60S ribosome subunit biogenesis protein Nip7, pre-PUA domain, eukaryotes | Nip7_N_euk | 2 |
IPR055360 | 55,360 | bAvd-like | bAvd | Domain | 1,459 | false | false | This entry includes accessory variability determinant bAvd protein from Bordetella phage BPP-1 and similar sequences from tailed bacteriophages and proteobacterial prophages. bAvd proteins are encoded by diversity-generating retroelements (DGR). They transfer coding information from a template region through an RNA int... | [] | [] | [] | 0 | [
"NCBIFAM",
"PFAM",
"CDD"
] | [
"NF033474",
"PF22296",
"cd16376"
] | [
"DivGenRetAVD",
"bAvd",
"Avd_like"
] | [
456,
1147,
1445
] | 3 | [] | [] | [] | 0 | [
"4dwl",
"8ub7",
"8ub8",
"8ub9",
"8uba",
"8ubb",
"8ubc",
"8ubd",
"8ube",
"8ubf"
] | 10 | [
"PUB00091539",
"PUB00136001",
"PUB00136002"
] | [
"15386016",
"23273427",
"23394941"
] | [
"Tropism switching in Bordetella bacteriophage defines a family of diversity-generating retroelements.",
"Structure of the essential diversity-generating retroelement protein bAvd and its functionally important interaction with reverse transcriptase.",
"Hand-holding for retrohoming in a molecular diversity danc... | [
2004,
2013,
2013
] | 3 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Daphnia pulex",
"Viruses",
"metagenomes"
] | [
3,
1408,
1,
32,
15
] | 5 | [] | [] | 0 | true | Domain | bAvd-like | bAvd-like | bAvd | 8 |
IPR055361 | 55,361 | tRNA (guanine-N(7)-)-methyltransferase TrmB, bacteria | tRNA_methyltr_TrmB_bact | Family | 22,755 | false | false | This entry represents tRNA (guanine-N-7) methyltransferase ( ) mainly from bacteria, which catalyses the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. Capping of the pre-mRNA 5' end by addition a monomethylated guanosine cap (m(7)G) is an essential and the earliest modification in the biogenesis of mR... | [] | [] | [] | 0 | [
"HAMAP"
] | [
"MF_01057"
] | [
"tRNA_methyltr_TrmB"
] | [
22755
] | 1 | [
"EC"
] | [
"2.1.1.33"
] | [
"EC:2.1.1.33"
] | 1 | [
"1yzh",
"2fca",
"3dxx",
"3dxy",
"3dxz",
"7nyb",
"7nzi",
"7nzj"
] | 8 | [
"PUB00017356",
"PUB00040616",
"PUB00043301",
"PUB00044795"
] | [
"12403464",
"16600901",
"18412263",
"17949828"
] | [
"Two proteins that form a complex are required for 7-methylguanosine modification of yeast tRNA.",
"Crystal structure of Bacillus subtilis TrmB, the tRNA (m7G46) methyltransferase.",
"Crystal structure of the methyltransferase domain of human TARBP1.",
"Evidence for a capping enzyme with specificity for the t... | [
2002,
2006,
2008,
2007
] | 4 | [
"IPR003358"
] | [] | 1 | 0 | 1 | [
"Bacteria",
"Eukaryota",
"candidate division MSBL1 archaeon SCGC-AAA382M17",
"unclassified sequences"
] | [
22232,
206,
1,
316
] | 4 | [
"Arabidopsis thaliana",
"Escherichia coli (strain K12)"
] | [
1,
1
] | 2 | true | Family | tRNA (guanine-N(7)-)-methyltransferase TrmB, bacteria | tRNA (guanine-N(7)-)-methyltransferase TrmB, bacteria | tRNA_methyltr_TrmB_bact | 2 |
IPR055362 | 55,362 | PTHB1, platform domain | PTHB1_pf_dom | Domain | 2,285 | false | false | This entry represents the platform domain found in PTHB1 protein and PTHB1 homolog from C. elegans. PTHB1 (also known as Bardet-Biedl syndrome 9 protein, BBS9) forms a part of the BBSome complex, which is required for ciliogenesis [ ]. PTHB1 is the major binding subunit of the IFT38 C-terminal tail, which assists the B... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23337"
] | [
"PTHB1_pf"
] | [
2285
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-CEL-5620922",
"R-HSA-5620922",
"R-MMU-5620922"
] | [
"REACTOME:R-CEL-5620922",
"REACTOME:R-HSA-5620922",
"REACTOME:R-MMU-5620922"
] | 3 | [
"6vbu",
"6vbv",
"6vnw",
"6voa",
"6xt9"
] | 5 | [
"PUB00153357"
] | [
"32510327"
] | [
"Near-atomic structures of the BBSome reveal the basis for BBSome activation and binding to GPCR cargoes."
] | [
2020
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
2285
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
8,
1,
12,
2,
4
] | 6 | true | Domain | PTHB1, platform domain | PTHB1, platform domain | PTHB1_pf_dom | 7 |
IPR055363 | 55,363 | PTHB1, hairpin domain | PTHB1_hp_dom | Domain | 2,277 | false | false | This entry represents a hairpin domain found in PTHB1 protein and PTHB1 homolog from C. elegans. PTHB1 (also known as Bardet-Biedl syndrome 9 protein, BBS9) forms a part of the BBSome complex, which is required for ciliogenesis [ ]. PTHB1 is the major binding subunit of the IFT38 C-terminal tail, which assists the BBSo... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23338"
] | [
"PTHB1_hp"
] | [
2277
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-CEL-5620922",
"R-HSA-5620922",
"R-MMU-5620922"
] | [
"REACTOME:R-CEL-5620922",
"REACTOME:R-HSA-5620922",
"REACTOME:R-MMU-5620922"
] | 3 | [
"6vbu",
"6vbv",
"6vnw",
"6voa",
"6xt9"
] | 5 | [
"PUB00153357"
] | [
"32510327"
] | [
"Near-atomic structures of the BBSome reveal the basis for BBSome activation and binding to GPCR cargoes."
] | [
2020
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
2277
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
8,
1,
12,
1,
4
] | 6 | true | Domain | PTHB1, hairpin domain | PTHB1, hairpin domain | PTHB1_hp_dom | 8 |
IPR055364 | 55,364 | PTHB1, C-terminal helix bundle domain | PTHB1_CtH_dom | Domain | 1,873 | false | false | This entry represents the C-terminal helix bundle (CtH) found in PTHB1 protein. PTHB1 (also known as Bardet-Biedl syndrome 9 protein, BBS9) forms a part of the BBSome complex, which is required for ciliogenesis [ ]. PTHB1 is the major binding subunit of the IFT38 C-terminal tail, which assists the BBSome in some of its... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23339"
] | [
"PTHB1_CtH"
] | [
1873
] | 1 | [
"REACTOME",
"REACTOME"
] | [
"R-HSA-5620922",
"R-MMU-5620922"
] | [
"REACTOME:R-HSA-5620922",
"REACTOME:R-MMU-5620922"
] | 2 | [
"6vbu",
"6vbv",
"6vnw",
"6voa",
"6xt9"
] | 5 | [
"PUB00153357"
] | [
"32510327"
] | [
"Near-atomic structures of the BBSome reveal the basis for BBSome activation and binding to GPCR cargoes."
] | [
2020
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1873
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
7,
1,
13,
1,
4
] | 5 | true | Domain | PTHB1, C-terminal helix bundle domain | PTHB1, C-terminal helix bundle domain | PTHB1_CtH_dom | 9 |
IPR055365 | 55,365 | Sublancin immunity protein SunI-like, PH domain | PH_SunI-like | Domain | 594 | false | false | Bacillus subtilis strain 168 produces the lantibiotic sublancin 168, a broad spectrum bacteriocin. SunI has been identified as the sublancin immunity protein. It belongs to a novel class of bacteriocin antagonists with a particular topology consisting of one N-terminal transmembrane domain and the bulk of the protein f... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23491"
] | [
"bPH_8"
] | [
594
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00077111"
] | [
"19047653"
] | [
"Immunity to the bacteriocin sublancin 168 Is determined by the SunI (YolF) protein of Bacillus subtilis."
] | [
2009
] | 1 | [] | [] | 0 | 0 | null | [
"Bacillota",
"Bacillus phage SPbeta",
"Phytophthora kernoviae 00238/432",
"human gut metagenome"
] | [
591,
1,
1,
1
] | 4 | [] | [] | 0 | true | Domain | Sublancin immunity protein SunI-like, PH domain | Sublancin immunity protein SunI-like, PH domain | PH_SunI-like | 8 |
IPR055366 | 55,366 | Small VCP/p97-interacting protein, metazoa | SVIP_metazoa | Family | 857 | false | false | This entry includes mammalian SVIP (small VCP/p97-interacting protein) SVIP and its homologues from animals. It was identified by yeast two-hybrid screening to be an interactive partner of VCP/p97. Mammalian VCP/p97 and its yeast counterpart Cdc48 participate in the formation of organelles, including the endoplasmic re... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR35269"
] | [
""
] | [
857
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-6798695",
"R-MMU-6798695",
"R-RNO-6798695"
] | [
"REACTOME:R-HSA-6798695",
"REACTOME:R-MMU-6798695",
"REACTOME:R-RNO-6798695"
] | 3 | [] | 0 | [
"PUB00075970",
"PUB00155951",
"PUB00155952"
] | [
"12529442",
"17872946",
"18793143"
] | [
"SVIP is a novel VCP/p97-interacting protein whose expression causes cell vacuolation.",
"Identification of SVIP as an endogenous inhibitor of endoplasmic reticulum-associated degradation.",
"Regulation of ER-associated degradation via p97/VCP-interacting motif."
] | [
2003,
2007,
2008
] | 3 | [
"IPR031632"
] | [] | 1 | 0 | 1 | [
"Metazoa"
] | [
857
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
6,
3,
1,
1,
4
] | 5 | true | Family | Small VCP/p97-interacting protein, metazoa | Small VCP/p97-interacting protein, metazoa | SVIP_metazoa | 6 |
IPR055367 | 55,367 | Large helicase-related protein, winged-helix domain 4 | WH4_Lhr | Domain | 6,527 | false | false | This entry represents WH4 of Lhr. It shows three α-helices followed by two loops or 'wings' and two β-strands forming an antiparallel β-sheet [ ]. This is a winged-helix (WH) domain is found in Large helicase-related protein from Escherichia coli (Lhr), DEAD/DEAH box helicase from Mycolicibacterium smegmatis ( ) and si... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23234"
] | [
"WHD_4th_Lhr"
] | [
6527
] | 1 | [] | [] | [] | 0 | [
"7lhl"
] | 1 | [
"PUB00155915"
] | [
"33744958"
] | [
"Oligomeric quaternary structure of Escherichia coli and Mycobacterium smegmatis Lhr helicases is nucleated by a novel C-terminal domain composed of five winged-helix modules."
] | [
2021
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
6474,
6,
47
] | 3 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Domain | Large helicase-related protein, winged-helix domain 4 | Large helicase-related protein, winged-helix domain 4 | WH4_Lhr | 2 |
IPR055368 | 55,368 | Large helicase-related protein, winged-helix domain 3 | WH3_Lhr | Domain | 6,508 | false | false | This entry represents WH3 of Lhr. It shows three α-helices followed by two loops or 'wings' and two β-strands forming an antiparallel β-sheet [ ]. This is a winged-helix (WH) domain is found in Large helicase-related protein from Escherichia coli (Lhr), DEAD/DEAH box helicase from Mycolicibacterium smegmatis ( ) and si... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23235"
] | [
"WHD_3rd_Lhr"
] | [
6508
] | 1 | [] | [] | [] | 0 | [
"7lhl"
] | 1 | [
"PUB00155915"
] | [
"33744958"
] | [
"Oligomeric quaternary structure of Escherichia coli and Mycobacterium smegmatis Lhr helicases is nucleated by a novel C-terminal domain composed of five winged-helix modules."
] | [
2021
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
6461,
3,
44
] | 3 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Domain | Large helicase-related protein, winged-helix domain 3 | Large helicase-related protein, winged-helix domain 3 | WH3_Lhr | 6 |
IPR055369 | 55,369 | Large helicase-related protein, winged-helix domain 2 | WH2_Lhr | Domain | 4,571 | false | false | This entry represents WH2 of Lhr. It shows three α-helices followed by two loops or 'wings' and two β-strands forming an antiparallel β-sheet [ ]. This is a winged-helix (WH) domain is found in Large helicase-related protein from Escherichia coli (Lhr), DEAD/DEAH box helicase from Mycolicibacterium smegmatis ( ) and si... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23236"
] | [
"WHD_2nd_Lhr"
] | [
4571
] | 1 | [] | [] | [] | 0 | [
"7lhl"
] | 1 | [
"PUB00155915"
] | [
"33744958"
] | [
"Oligomeric quaternary structure of Escherichia coli and Mycobacterium smegmatis Lhr helicases is nucleated by a novel C-terminal domain composed of five winged-helix modules."
] | [
2021
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
4539,
2,
30
] | 3 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Domain | Large helicase-related protein, winged-helix domain 2 | Large helicase-related protein, winged-helix domain 2 | WH2_Lhr | 9 |
IPR055370 | 55,370 | Lsr2, DNA-binding domain | Lsr2_DNA-bd | Domain | 8,781 | false | false | This entry represents the DNA-binding domain found at the C-terminal of Lsr2. It binds AT-rich regions of chromosomal DNA and physically protects DNA from damage by reactive oxygen intermediates [ , ]. This domain is also found in protein Ku from Mycobacterium phage Omega and Type II methyltransferase M.SalI. This doma... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23359"
] | [
"Lsr2_DNA-bd"
] | [
8781
] | 1 | [] | [] | [] | 0 | [
"2kng",
"6qkp",
"6qkq"
] | 3 | [
"PUB00056035",
"PUB00056036",
"PUB00065750",
"PUB00092826"
] | [
"18776007",
"17046956",
"22719899",
"20133735"
] | [
"Lsr2 of Mycobacterium represents a novel class of H-NS-like proteins.",
"Escherichia coli histone-like protein H-NS preferentially binds to horizontally acquired DNA in association with RNA polymerase.",
"The structure of the oligomerization domain of Lsr2 from Mycobacterium tuberculosis reveals a mechanism fo... | [
2008,
2006,
2012,
2010
] | 4 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Viruses",
"metagenomes"
] | [
8583,
8,
173,
17
] | 4 | [] | [] | 0 | true | Domain | Lsr2, DNA-binding domain | Lsr2, DNA-binding domain | Lsr2_DNA-bd | 3 |
IPR055371 | 55,371 | SpaA-like, prealbumin fold domain subgroup 4 | SpaA_PFL_dom_4 | Domain | 540 | false | false | This entry represents a domain found in uncharacterised bacterial proteins. Some members are likely to contain an isopeptide bond. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24514"
] | [
"SpaA_4"
] | [
540
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Durusdinium trenchii",
"Nitrosopumilus ureiphilus",
"ecological metagenomes"
] | [
521,
1,
1,
17
] | 4 | [] | [] | 0 | true | Domain | SpaA-like, prealbumin fold domain subgroup 4 | SpaA-like, prealbumin fold domain subgroup 4 | SpaA_PFL_dom_4 | 4 |
IPR055372 | 55,372 | Carbohydrate-binding module family 96 | CBM96 | Domain | 5,962 | false | false | This entry represents a CBM domain, a member of the family, found in functionally diverse multi-domain proteins including tRNA nuclease WapA, alginate lyase from Defluviitalea phaphyphila, chondroitinase from Dysgonomonas sp. The CBM96 domain from the latter proteins, has been structurally characterised. It folds into ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24517"
] | [
"CBM96"
] | [
5962
] | 1 | [] | [] | [] | 0 | [
"7vbo",
"8wab"
] | 2 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
88,
5353,
392,
10,
119
] | 5 | [] | [] | 0 | true | Domain | Carbohydrate-binding module family 96 | Carbohydrate-binding module family 96 | CBM96 | 7 |
IPR055373 | 55,373 | Ribophorin II, N-terminal domain | Ribophorin_II_N | Domain | 3,605 | false | false | This entry represents the N-terminal domain of eukaryotic Ribophorin II (RPN2, also known as dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2) proteins, which forms an α/α6 structure. The mammalian oligosaccharyltransferase (OST) is a protein complex that effects the cotranslational N-glycosylat... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF05817"
] | [
"Ribophorin_II"
] | [
3605
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-1799339",
"R-HSA-446203",
"R-HSA-9694548",
"R-HSA-9768727",
"R-MMU-9768727",
"R-RNO-9768727"
] | [
"REACTOME:R-HSA-1799339",
"REACTOME:R-HSA-446203",
"REACTOME:R-HSA-9694548",
"REACTOME:R-HSA-9768727",
"REACTOME:R-MMU-9768727",
"REACTOME:R-RNO-9768727"
] | 6 | [
"6s7o",
"6s7t",
"8b6l",
"8pn9"
] | 4 | [
"PUB00011452",
"PUB00155776"
] | [
"10826490",
"31831667"
] | [
"Localization of ribophorin II to the endoplasmic reticulum involves both its transmembrane and cytoplasmic domains.",
"Cryo-electron microscopy structures of human oligosaccharyltransferase complexes OST-A and OST-B."
] | [
2000,
2019
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Paramaledivibacter caminithermalis (strain DSM 15212 / CIP 107654 / DViRD3)"
] | [
3604,
1
] | 2 | [
"Arabidopsis thaliana",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
6,
2,
2,
6,
4,
2,
8,
22
] | 8 | true | Domain | Ribophorin II, N-terminal domain | Ribophorin II, N-terminal domain | Ribophorin_II_N | 3 |
IPR055374 | 55,374 | Ribophorin II, third domain | Ribophorin_II_3rd | Domain | 3,995 | false | false | This entry represents the third domain of Ribophorin II (RPN2, also known as dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2) proteins, which may adopt a β-sandwich fold. The mammalian oligosaccharyltransferase (OST) is a protein complex that effects the cotranslational N-glycosylation of newly... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23860"
] | [
"Ribophorin_II_3rd"
] | [
3995
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-1799339",
"R-HSA-446203",
"R-HSA-9694548",
"R-HSA-9768727",
"R-MMU-9768727",
"R-RNO-9768727"
] | [
"REACTOME:R-HSA-1799339",
"REACTOME:R-HSA-446203",
"REACTOME:R-HSA-9694548",
"REACTOME:R-HSA-9768727",
"REACTOME:R-MMU-9768727",
"REACTOME:R-RNO-9768727"
] | 6 | [
"6s7o",
"6s7t",
"8b6l",
"8pn9"
] | 4 | [
"PUB00011452",
"PUB00155776"
] | [
"10826490",
"31831667"
] | [
"Localization of ribophorin II to the endoplasmic reticulum involves both its transmembrane and cytoplasmic domains.",
"Cryo-electron microscopy structures of human oligosaccharyltransferase complexes OST-A and OST-B."
] | [
2000,
2019
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
3995
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
6,
1,
2,
2,
6,
4,
2,
8,
20
] | 9 | true | Domain | Ribophorin II, third domain | Ribophorin II, third domain | Ribophorin_II_3rd | 5 |
IPR055375 | 55,375 | Ribophorin II, second domain | Ribophorin_II_2nd | Domain | 3,461 | false | false | This entry represents the second domain of Ribophorin II (RPN2, also known as dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2) proteins, which adopts a β-sandwich fold. The mammalian oligosaccharyltransferase (OST) is a protein complex that effects the cotranslational N-glycosylation of newly s... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23861"
] | [
"Ribophorin_II_2nd"
] | [
3461
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-1799339",
"R-HSA-446203",
"R-HSA-9694548",
"R-HSA-9768727",
"R-MMU-9768727",
"R-RNO-9768727"
] | [
"REACTOME:R-HSA-1799339",
"REACTOME:R-HSA-446203",
"REACTOME:R-HSA-9694548",
"REACTOME:R-HSA-9768727",
"REACTOME:R-MMU-9768727",
"REACTOME:R-RNO-9768727"
] | 6 | [
"6s7o",
"6s7t",
"8b6l",
"8pn9"
] | 4 | [
"PUB00011452",
"PUB00155776"
] | [
"10826490",
"31831667"
] | [
"Localization of ribophorin II to the endoplasmic reticulum involves both its transmembrane and cytoplasmic domains.",
"Cryo-electron microscopy structures of human oligosaccharyltransferase complexes OST-A and OST-B."
] | [
2000,
2019
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
3461
] | 1 | [
"Arabidopsis thaliana",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
6,
2,
2,
6,
4,
2,
8,
20
] | 8 | true | Domain | Ribophorin II, second domain | Ribophorin II, second domain | Ribophorin_II_2nd | 5 |
IPR055377 | 55,377 | GH3, middle domain | GH3_M | Domain | 15,525 | false | false | This entry represents the middle domain of the GH3 IAA-amido conjugating enzyme family, which consists of a β-barrel [ ]. This entry includes GH3 IAA-amido conjugating enzyme family, which consists of proteins that catalyse the synthesis of amino acid conjugates with indole-3-acetic acid (IAA) or jasmonate (JA), which ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23571"
] | [
"GH3_M"
] | [
15525
] | 1 | [
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC"... | [
"6.3.2.-",
"PWY-6289",
"PWY-6374",
"PWY-6378",
"PWY-6379",
"PWY-6409",
"PWY-6574",
"PWY-7510",
"PWY-7533",
"PWY-7542",
"PWY-7543",
"PWY-7549",
"PWY-7555",
"PWY-7556",
"PWY-7561",
"PWY-7563",
"PWY-7565",
"PWY-7569",
"PWY-7570",
"PWY-7571",
"PWY-7577",
"PWY-7600",
"PWY-7605... | [
"EC:6.3.2.-",
"METACYC:PWY-6289",
"METACYC:PWY-6374",
"METACYC:PWY-6378",
"METACYC:PWY-6379",
"METACYC:PWY-6409",
"METACYC:PWY-6574",
"METACYC:PWY-7510",
"METACYC:PWY-7533",
"METACYC:PWY-7542",
"METACYC:PWY-7543",
"METACYC:PWY-7549",
"METACYC:PWY-7555",
"METACYC:PWY-7556",
"METACYC:PWY-7... | 44 | [
"4b2g",
"4epl",
"4epm",
"4eq4",
"4eql",
"4ewv",
"4l39",
"5ech",
"5eci",
"5eck",
"5ecl",
"5ecm",
"5ecn",
"5eco",
"5ecp",
"5ecq",
"5ecr",
"5gzz",
"5kod",
"6avh",
"6e1q",
"6oms",
"7dk8",
"7vka",
"9fwd",
"9fxd"
] | 26 | [
"PUB00019613",
"PUB00059590",
"PUB00077101"
] | [
"10066623",
"22628555",
"15659623"
] | [
"Molecular mechanisms of auxin action.",
"Structural Basis for Prereceptor Modulation of Plant Hormones by GH3 Proteins.",
"Characterization of an Arabidopsis enzyme family that conjugates amino acids to indole-3-acetic acid."
] | [
1998,
2012,
2005
] | 3 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"metagenomes"
] | [
8,
6417,
9003,
2,
95
] | 5 | [
"Arabidopsis thaliana",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
93,
5,
3,
4,
28,
1,
50
] | 7 | true | Domain | GH3, middle domain | GH3, middle domain | GH3_M | 6 |
IPR055378 | 55,378 | GH3, C-terminal domain | GH3_C | Domain | 14,692 | false | false | This entry represents the C-terminal domain of the GH3 IAA-amido conjugating enzyme family, which consists of a single four-stranded β-sheet bracketed by two α-helices on each side [ , ]. This entry includes GH3 IAA-amido conjugating enzyme family, which consists of proteins that catalyse the synthesis of amino acid co... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23572"
] | [
"GH3_C"
] | [
14692
] | 1 | [
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC"... | [
"6.3.2.-",
"PWY-6289",
"PWY-6374",
"PWY-6378",
"PWY-6379",
"PWY-6409",
"PWY-6574",
"PWY-7510",
"PWY-7533",
"PWY-7542",
"PWY-7543",
"PWY-7549",
"PWY-7555",
"PWY-7556",
"PWY-7561",
"PWY-7563",
"PWY-7565",
"PWY-7569",
"PWY-7570",
"PWY-7571",
"PWY-7577",
"PWY-7600",
"PWY-7605... | [
"EC:6.3.2.-",
"METACYC:PWY-6289",
"METACYC:PWY-6374",
"METACYC:PWY-6378",
"METACYC:PWY-6379",
"METACYC:PWY-6409",
"METACYC:PWY-6574",
"METACYC:PWY-7510",
"METACYC:PWY-7533",
"METACYC:PWY-7542",
"METACYC:PWY-7543",
"METACYC:PWY-7549",
"METACYC:PWY-7555",
"METACYC:PWY-7556",
"METACYC:PWY-7... | 44 | [
"4b2g",
"4epl",
"4epm",
"4eq4",
"4eql",
"4ewv",
"4l39",
"5ech",
"5eci",
"5eck",
"5ecl",
"5ecm",
"5ecn",
"5eco",
"5ecp",
"5ecq",
"5ecr",
"5gzz",
"5kod",
"6avh",
"6e1q",
"6oms",
"7dk8",
"7vka",
"9fwd",
"9fxd"
] | 26 | [
"PUB00019613",
"PUB00059590",
"PUB00077101",
"PUB00156023"
] | [
"10066623",
"22628555",
"15659623",
"29462792"
] | [
"Molecular mechanisms of auxin action.",
"Structural Basis for Prereceptor Modulation of Plant Hormones by GH3 Proteins.",
"Characterization of an Arabidopsis enzyme family that conjugates amino acids to indole-3-acetic acid.",
"<i>Arabidopsis thaliana</i> GH3.15 acyl acid amido synthetase has a highly specif... | [
1998,
2012,
2005,
2018
] | 4 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
4,
5916,
8677,
95
] | 4 | [
"Arabidopsis thaliana",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
95,
3,
2,
4,
24,
1,
54
] | 7 | true | Domain | GH3, C-terminal domain | GH3, C-terminal domain | GH3_C | 6 |
IPR055379 | 55,379 | BBS2, platform domain | BBS2_pf_dom | Domain | 1,838 | false | false | This entry represents the platform domain of BBS2. BBSome complex member BBS2 (BBS2) is one of the BBS proteins that form the BBSome complex found in vertebrates and nematodes, including humans, mice, and Caenorhabditis elegans. The BBSome complex is required for ciliogenesis, as well as the assembly and movement of in... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23350"
] | [
"BBS2_pf"
] | [
1838
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-CEL-5620922",
"R-HSA-5620922",
"R-MMU-5620922",
"R-RNO-5620922"
] | [
"REACTOME:R-CEL-5620922",
"REACTOME:R-HSA-5620922",
"REACTOME:R-MMU-5620922",
"REACTOME:R-RNO-5620922"
] | 4 | [
"6vbu",
"6vbv",
"6vnw",
"6voa"
] | 4 | [
"PUB00043592",
"PUB00060532",
"PUB00067726",
"PUB00070006",
"PUB00093551",
"PUB00153357"
] | [
"18334641",
"17574030",
"20395968",
"19150989",
"22922713",
"32510327"
] | [
"Bardet-Biedl syndrome proteins are required for the localization of G protein-coupled receptors to primary cilia.",
"A core complex of BBS proteins cooperates with the GTPase Rab8 to promote ciliary membrane biogenesis.",
"The primary cilium: a signalling centre during vertebrate development.",
"Requirement ... | [
2008,
2007,
2010,
2009,
2012,
2020
] | 6 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1838
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
2,
14,
1,
3
] | 5 | true | Domain | BBS2, platform domain | BBS2, platform domain | BBS2_pf_dom | 6 |
IPR055381 | 55,381 | BBS2, C-terminal helix bundle domain | BBS2_CtH_dom | Domain | 1,535 | false | false | This entry represents the C-terminal helix bundle domain of BBS2. BBSome complex member BBS2 (BBS2) is one of the BBS proteins that form the BBSome complex found in vertebrates and nematodes, including humans, mice, and Caenorhabditis elegans. The BBSome complex is required for ciliogenesis, as well as the assembly and... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23351"
] | [
"BBS2_CtH"
] | [
1535
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-5620922",
"R-MMU-5620922",
"R-RNO-5620922"
] | [
"REACTOME:R-HSA-5620922",
"REACTOME:R-MMU-5620922",
"REACTOME:R-RNO-5620922"
] | 3 | [
"6vbu",
"6vbv",
"6vnw",
"6voa"
] | 4 | [
"PUB00043592",
"PUB00060532",
"PUB00067726",
"PUB00070006",
"PUB00093551",
"PUB00153357"
] | [
"18334641",
"17574030",
"20395968",
"19150989",
"22922713",
"32510327"
] | [
"Bardet-Biedl syndrome proteins are required for the localization of G protein-coupled receptors to primary cilia.",
"A core complex of BBS proteins cooperates with the GTPase Rab8 to promote ciliary membrane biogenesis.",
"The primary cilium: a signalling centre during vertebrate development.",
"Requirement ... | [
2008,
2007,
2010,
2009,
2012,
2020
] | 6 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1535
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
13,
2,
3
] | 4 | true | Domain | BBS2, C-terminal helix bundle domain | BBS2, C-terminal helix bundle domain | BBS2_CtH_dom | 4 |
IPR055384 | 55,384 | Domain of unknown function DUF7604 | DUF7604 | Domain | 389 | false | false | This domain is found in uncharacterised bacterial proteins. It is usually associated with von Willebrand factor type A domain ( ), which is inserted into the domain core. Members of this entry are likely to contain an intramolecular isopeptide bond. The domain represented by this entry is predicted to fold into a β-san... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24558"
] | [
"DUF7604"
] | [
389
] | 1 | [] | [] | [] | 0 | [
"7vcn",
"7vcr",
"7w6b"
] | 3 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"uncultured organism"
] | [
388,
1
] | 2 | [] | [] | 0 | true | Domain | Domain of unknown function DUF7604 | Domain of unknown function DUF7604 | DUF7604 | 5 |
IPR055385 | 55,385 | Tip attachment protein J, HDII-ins2 domain | GpJ_HDII-ins2 | Domain | 5,065 | false | false | This domain is found at the N-terminal of Tip attachment protein J from the bacteriophage lambda (GpJ) and similar sequences from tailed bacteriophages and bacterial prophages [ ]. This domain, which shows an Ig-like structure, undergoes rotation and determines the narrowest diameter within the hub domains (HDs) region... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24801"
] | [
"FNIII-A_GpJ"
] | [
5065
] | 1 | [] | [] | [] | 0 | [
"8iyk",
"8iyl",
"8k35",
"8xcg",
"8xci",
"9e7m",
"9l9p"
] | 7 | [
"PUB00075602",
"PUB00075672",
"PUB00155633",
"PUB00155963"
] | [
"6228546",
"23542343",
"38096144",
"38760367"
] | [
"Proteinase sensitivity of bacteriophage lambda tail proteins gpJ and pH in complexes with the lambda receptor.",
"Tail tip proteins related to bacteriophage λ gpL coordinate an iron-sulfur cluster.",
"Structure of the siphophage neck-Tail complex suggests that conserved tail tip proteins facilitate receptor bi... | [
1984,
2013,
2023,
2024
] | 4 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Viruses",
"metagenomes"
] | [
4558,
11,
462,
34
] | 4 | [] | [] | 0 | true | Domain | Tip attachment protein J, HDII-ins2 domain | Tip attachment protein J, HDII-ins2 domain | GpJ_HDII-ins2 | 2 |
IPR055386 | 55,386 | Fanconi anaemia group A protein, helical domain | FANCA_helical | Domain | 1,217 | false | false | This entry represents the helical domain of Fanconi anaemia group A protein (FANCA), found in the central region of the protein, which is packed against the arcC half of the C-terminal domain [ , ]. Fanconi anemia (FA) is a human disorder characterised by cancer susceptibility and cellular sensitivity to DNA crosslinks... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24781"
] | [
"FANCA_helical"
] | [
1217
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-6783310",
"R-HSA-9833482",
"R-MMU-6783310",
"R-MMU-9833482"
] | [
"REACTOME:R-HSA-6783310",
"REACTOME:R-HSA-9833482",
"REACTOME:R-MMU-6783310",
"REACTOME:R-MMU-9833482"
] | 4 | [
"6lhs",
"6lhu",
"7kzp",
"7kzq",
"7kzr",
"7kzs",
"7kzt",
"7kzv"
] | 8 | [
"PUB00054178",
"PUB00089968",
"PUB00101197",
"PUB00155624"
] | [
"20347428",
"29017571",
"33686268",
"32002546"
] | [
"A histone-fold complex and FANCM form a conserved DNA-remodeling complex to maintain genome stability.",
"DNA damage response and cancer therapeutics through the lens of the Fanconi Anemia DNA repair pathway.",
"Structure of the FA core ubiquitin ligase closing the ID clamp on DNA.",
"Structural basis of the... | [
2010,
2017,
2021,
2020
] | 4 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1217
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
7,
3,
5
] | 4 | true | Domain | Fanconi anaemia group A protein, helical domain | Fanconi anaemia group A protein, helical domain | FANCA_helical | 2 |
IPR055387 | 55,387 | Fanconi anaemia group A protein, arcN subdomain | FANCA_arcN | Domain | 1,071 | false | false | This entry represents the N-terminal half of the arc-shaped C-terminal domain of Fanconi anaemia group A protein (FANCA), named arcN, which interacts with the C-terminal half of a second FANCA molecule in a head-to-tail manner to form a pseudo-symmetric dimeric interface [ ]. The C-terminal domain of FANCA (arcN and ar... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24783"
] | [
"FANCA_arcN"
] | [
1071
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-6783310",
"R-HSA-9833482",
"R-MMU-6783310",
"R-MMU-9833482"
] | [
"REACTOME:R-HSA-6783310",
"REACTOME:R-HSA-9833482",
"REACTOME:R-MMU-6783310",
"REACTOME:R-MMU-9833482"
] | 4 | [
"6lhs",
"6lhu",
"7kzp",
"7kzq",
"7kzr",
"7kzs",
"7kzt",
"7kzv"
] | 8 | [
"PUB00054178",
"PUB00089968",
"PUB00101197",
"PUB00155624"
] | [
"20347428",
"29017571",
"33686268",
"32002546"
] | [
"A histone-fold complex and FANCM form a conserved DNA-remodeling complex to maintain genome stability.",
"DNA damage response and cancer therapeutics through the lens of the Fanconi Anemia DNA repair pathway.",
"Structure of the FA core ubiquitin ligase closing the ID clamp on DNA.",
"Structural basis of the... | [
2010,
2017,
2021,
2020
] | 4 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1071
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
5,
3,
5
] | 4 | true | Domain | Fanconi anaemia group A protein, arcN subdomain | Fanconi anaemia group A protein, arcN subdomain | FANCA_arcN | 1 |
IPR055388 | 55,388 | Domain of unknown function DUF7617 | DUF7617 | Domain | 129 | false | false | This domain is found in multiple copies in a number of bacterial proteins mainly from Actinomycetes. It is closely related to domains represented by and . Similarly to them, this domain contains a conserved N-terminal lysine and a C-terminal asparagine with central aspartate/glutamate residues suggesting that some memb... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24593"
] | [
"DUF7617"
] | [
129
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacillati"
] | [
129
] | 1 | [] | [] | 0 | true | Domain | Domain of unknown function DUF7617 | Domain of unknown function DUF7617 | DUF7617 | 5 |
IPR055389 | 55,389 | L-arabinose isomerase, N-terminal domain | AraA_N | Domain | 6,556 | false | false | This entry represents the N-terminal domain of L-arabinose isomerases, AraA, which is composed of a central parallel β-sheet packed with α-helices on both sides and with topology similar to the topology of the middle domain [ ]. This entry includes L-arabinose isomerases, AraA, ( ). These enzymes catalyse the reaction:... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF02610"
] | [
"AraA_N"
] | [
6556
] | 1 | [
"EC"
] | [
"5.3.1.4"
] | [
"EC:5.3.1.4"
] | 1 | [
"2ajt",
"2hxg",
"4f2d",
"4lql",
"4r1o",
"4r1p",
"4r1q",
"7ch3",
"7chl",
"7cwv",
"7cx7",
"7cxo",
"7cyy"
] | 13 | [
"PUB00008241",
"PUB00039308"
] | [
"9084180",
"16756997"
] | [
"The Bacillus subtilis L-arabinose (ara) operon: nucleotide sequence, genetic organization and expression.",
"Crystal structure of Escherichia coli L-arabinose isomerase (ECAI), the putative target of biological tagatose production."
] | [
1997,
2006
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Halorhabdus",
"unclassified sequences"
] | [
6473,
20,
3,
60
] | 4 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Domain | L-arabinose isomerase, N-terminal domain | L-arabinose isomerase, N-terminal domain | AraA_N | 6 |
IPR055390 | 55,390 | L-arabinose isomerase, central domain | AraA_central | Domain | 6,761 | false | false | This entry represents a domain found central in L-arabinose isomerases, AraA. The domain represented by this entry is composed of a central parallel β-sheet packed with α-helices on both sides and with topology similar to the topology of the N-terminal domain [ ]. This entry includes L-arabinose isomerases, AraA, ( ). ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24856"
] | [
"AraA_central"
] | [
6761
] | 1 | [
"EC"
] | [
"5.3.1.4"
] | [
"EC:5.3.1.4"
] | 1 | [
"2ajt",
"2hxg",
"4f2d",
"4lql",
"4r1o",
"4r1p",
"4r1q",
"7ch3",
"7chl",
"7cwv",
"7cx7",
"7cxo",
"7cyy"
] | 13 | [
"PUB00008241",
"PUB00039308"
] | [
"9084180",
"16756997"
] | [
"The Bacillus subtilis L-arabinose (ara) operon: nucleotide sequence, genetic organization and expression.",
"Crystal structure of Escherichia coli L-arabinose isomerase (ECAI), the putative target of biological tagatose production."
] | [
1997,
2006
] | 2 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
9,
6650,
24,
78
] | 4 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Domain | L-arabinose isomerase, central domain | L-arabinose isomerase, central domain | AraA_central | 6 |
IPR055391 | 55,391 | BROMI, N-terminal domain | BROMI_N | Domain | 1,160 | false | false | This entry represents the N-terminal domain of BROMI. The Broad-minded family of proteins is essential for the proper response to Sonic hedgehog (Shh) signalling during neural tube development. Members of the Broad-minded family collaborate with cyclin-dependent kinase 20 (CDK20) to regulate the structure of the primar... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23431"
] | [
"BROMI_N"
] | [
1160
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00076775",
"PUB00156024"
] | [
"20159594",
"35609210"
] | [
"Broad-minded links cell cycle-related kinase to cilia assembly and hedgehog signal transduction.",
"BROMI/TBC1D32 together with CCRK/CDK20 and FAM149B1/JBTS36 contributes to intraflagellar transport turnaround involving ICK/CILK1."
] | [
2010,
2022
] | 2 | [] | [] | 0 | 0 | null | [
"Opisthokonta"
] | [
1160
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
6,
2,
1,
3
] | 4 | true | Domain | BROMI, N-terminal domain | BROMI, N-terminal domain | BROMI_N | 5 |
IPR055392 | 55,392 | BROMI, C-terminal Rab TBC-like domain | BROMI_C | Domain | 1,666 | false | false | This entry represents the C-terminal Rab TBC-like domain [ ]. The Broad-minded family of proteins is essential for the proper response to Sonic hedgehog (Shh) signalling during neural tube development. Members of the Broad-minded family collaborate with cyclin-dependent kinase 20 (CDK20) to regulate the structure of th... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23440"
] | [
"BROMI_C"
] | [
1666
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00076775",
"PUB00156024"
] | [
"20159594",
"35609210"
] | [
"Broad-minded links cell cycle-related kinase to cilia assembly and hedgehog signal transduction.",
"BROMI/TBC1D32 together with CCRK/CDK20 and FAM149B1/JBTS36 contributes to intraflagellar transport turnaround involving ICK/CILK1."
] | [
2010,
2022
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1666
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
4,
2,
1,
4
] | 4 | true | Domain | BROMI, C-terminal Rab TBC-like domain | BROMI, C-terminal Rab TBC-like domain | BROMI_C | 3 |
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