LiteFold/InterPro · Datasets at Hugging Face

IPR055154

55,154

L-gulonolactone oxidase 2-like, C-terminal domain

GULLO2-like_C

Domain

2,153

false

This domain is found at the C-terminal end of L-gulonolactone oxidase from Arabidopsis thaliana (GULLO2) and similar plant proteins. This enzyme catalyses the oxidation of L-gulono-1,4-lactone to ascorbic acid [ ]. This short domain is predicted to contain a β-hairpin and have structural similarity with omega toxins.

[]

0

[ "PFAM" ]

[ "PF22906" ]

[ "GULLO2-like_3rd" ]

[ 2153 ]

1

[ "EC" ]

[ "1.1.3.8" ]

[ "EC:1.1.3.8" ]

1

[]

0

[ "PUB00074288" ]

[ "20622436" ]

[ "The contribution of Arabidopsis homologs of L-gulono-1,4-lactone oxidase to the biosynthesis of ascorbic acid." ]

[ 2010 ]

1

[]

0

null

[ "Eukaryota", "Pseudomonadati" ]

[ 2120, 33 ]

2

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 27, 20, 15 ]

3

true

Domain

L-gulonolactone oxidase 2-like, C-terminal domain

GULLO2-like_C

4

IPR055155

55,155

Tetracyclin repressor SMU_134-like, C-terminal domain

SMU_134-like_C

Domain

52

false

This domain is found at the C-terminal of Transcriptional regulator SMU_134 ( ) from Streptococcus mutans and similar sequences from firmicutes. It is normally found associated with . This domain shows an all-α configuration.

[]

0

[ "PFAM" ]

[ "PF22568" ]

[ "Tet_C_40" ]

[ 52 ]

1

[]

0

[ "3mvp" ]

1

[]

0

[]

0

null

[ "Bacillota" ]

[ 52 ]

1

[]

0

true

Domain

Tetracyclin repressor SMU_134-like, C-terminal domain

SMU_134-like_C

5

IPR055156

55,156

Formimidoylglutamate deiminase, N-terminal domain

HutF-like_N

Domain

3,506

false

This entry represents a small domain found at the N-terminal end of Formimidoylglutamate deiminase from Pseudomonas aeruginosa (also known as N-formimino-L-Glutamate Iminohydrolase, HutF, , ), N-acetylgalactosamine-6-phosphate deacetylasefrom Escherichia coli (AgaA) and similar proteins predominantly found in proteobac...

[]

0

[ "PFAM" ]

[ "PF22429" ]

[ "HutF_N" ]

[ 3506 ]

1

[]

0

[ "3mdu", "3mdw", "4f0l", "4rdv", "4rdw", "4rzb" ]

6

[ "PUB00086892", "PUB00101363", "PUB00101364" ]

[ "23634833", "17128965", "16475788" ]

[ "Genetic analysis of the roles of agaA, agaI, and agaS genes in the N-acetyl-D-galactosamine and D-galactosamine catabolic pathways in Escherichia coli strains O157:H7 and C.", "Mechanistic characterization of N-formimino-L-glutamate iminohydrolase from Pseudomonas aeruginosa.", "Annotating enzymes of unknown f...

[ 2013, 2006, 2006 ]

3

[]

0

null

[ "Bacteria", "Eukaryota", "ecological metagenomes" ]

[ 3491, 3, 12 ]

3

[]

0

true

Domain

Formimidoylglutamate deiminase, N-terminal domain

HutF-like_N

5

IPR055157

55,157

Flagellar biosynthesis protein FlhF, N domain

FlhF_N

Domain

35

false

This domain is found in Flagellar biosynthesis protein FlhF from Bacillus subtilis, a protein that is necessary for flagellar biosynthesis. FlhF contains a basic N-terminal domain followed by the conserved NG domain, which can be divided into two segments: the N domain (this entry) and the G domain ( ) [ ].

[]

0

[ "PFAM" ]

[ "PF22510" ]

[ "FlhF_N" ]

[ 35 ]

1

[]

0

[ "2px0", "2px3", "3syn" ]

3

[ "PUB00045457" ]

[ "17699634" ]

[ "The crystal structure of the third signal-recognition particle GTPase FlhF reveals a homodimer with bound GTP." ]

[ 2007 ]

1

[]

0

null

[ "Bacillus" ]

[ 35 ]

1

[]

0

true

Domain

Flagellar biosynthesis protein FlhF, N domain

FlhF_N

6

IPR055158

55,158

Response regulator protein ChxR, N-terminal domain

ChxR_N

Domain

29

false

This domain is found at the N-terminal of the response regulator protein ChxR from Chlamydia trachomatis ( ). ChxR is organised into a receiver domain, represented in this entry, and a C-terminal effector domain ( ). Dimerisation occurs through the receiver domain. It shows an α-β configuration [ ].

[]

0

[ "PFAM" ]

[ "PF22368" ]

[ "ChxR_N" ]

[ 29 ]

1

[]

0

[ "3q7r", "3q7s", "3q7t" ]

3

[ "PUB00056962" ]

[ "21775428" ]

[ "The atypical response regulator protein ChxR has structural characteristics and dimer interface interactions that are unique within the OmpR/PhoB subfamily." ]

[ 2011 ]

1

[ "IPR001789" ]

[]

1

0

1

[ "Chlamydia" ]

[ 29 ]

1

[]

0

true

Domain

Response regulator protein ChxR, N-terminal domain

ChxR_N

9

IPR055159

55,159

DdMyo7, FERM domain

DdMyo7_FERM

Domain

7

false

This entry represents the C-terminal FERM domain found in Myo7 from Dictyostelium discoideum [ ], a protein that is essential for the extension of filopodia, plasma membrane protrusions filled with parallel bundles of F-actin similarly as metazoan Myo10, which suggests a high degree of functional conservation throughou...

[]

0

[ "PFAM" ]

[ "PF22406" ]

[ "DdMyo7_FERM" ]

[ 7 ]

1

[]

0

[ "5ejr", "5ejs" ]

2

[ "PUB00139720" ]

[ "27166421" ]

[ "Myosin MyTH4-FERM structures highlight important principles of convergent evolution." ]

[ 2016 ]

1

[]

0

null

[ "Dictyostelia" ]

[ 7 ]

1

[]

0

true

Domain

DdMyo7, FERM domain

DdMyo7_FERM

2

IPR055162

55,162

RET, cysteine rich domain

RET_CRD

Domain

1,348

false

RET is a single transmembrane-spanning receptor tyrosine kinase (RTK) that plays critical roles in the development of vertebrates. Structural analysis indicate that the ligand-binding RET ectodomain (RET-ECD) contains four consecutive cadherin-like domains (CLD1-CLD4) followed by a membrane-proximal cysteine-rich domai...

[]

0

[ "PFAM" ]

[ "PF22540" ]

[ "RET_CRD" ]

[ 1348 ]

1

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "2.7.10.1", "R-HSA-5673001", "R-HSA-8853659", "R-HSA-9768919", "R-HSA-9830364", "R-HSA-9830674", "R-MMU-5673001", "R-MMU-8853659", "R-RNO-5673001", "R-RNO-8853659" ]

[ "EC:2.7.10.1", "REACTOME:R-HSA-5673001", "REACTOME:R-HSA-8853659", "REACTOME:R-HSA-9768919", "REACTOME:R-HSA-9830364", "REACTOME:R-HSA-9830674", "REACTOME:R-MMU-5673001", "REACTOME:R-MMU-8853659", "REACTOME:R-RNO-5673001", "REACTOME:R-RNO-8853659" ]

10

[ "4ux8", "6gl7", "6q2j", "6q2n", "6q2o", "6q2r", "6q2s", "7aml" ]

8

[ "PUB00154200", "PUB00154201" ]

[ "33484636", "31535977" ]

[ "A two-site flexible clamp mechanism for RET-GDNF-GFRα1 assembly reveals both conformational adaptation and strict geometric spacing.", "Cryo-EM analyses reveal the common mechanism and diversification in the activation of RET by different ligands." ]

[ 2021, 2019 ]

2

[]

0

null

[ "Bilateria", "Candidatus Doudnabacteria bacterium CG10_big_fil_rev_8_21_14_0_10_41_10", "Candidatus Iainarchaeum sp." ]

[ 1345, 1, 2 ]

3

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 4, 8, 2, 3 ]

5

true

Domain

RET, cysteine rich domain

RET_CRD

7

IPR055163

55,163

ALK/LTK-like, glycine-rich domain

ALK/LTK-like_GRD

Domain

3,707

false

This entry represents the glycine-rich domain (GRD) from the Anaplastic lymphoma kinase (ALK), the closely related leukocyte tyrosine kinase (LTK) and similar proteins. ALK and LTK have been recently deorphanized receptor tyrosine kinases [ , ]. They are involved in neural development, cancer and autoimmune diseases. A...

[]

0

[ "PFAM" ]

[ "PF12810" ]

[ "ALK_LTK_GRD" ]

[ 3707 ]

1

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "2.7.10.1", "R-DRE-9842663", "R-HSA-201556", "R-HSA-9700645", "R-HSA-9717264", "R-HSA-9717301", "R-HSA-9717316", "R-HSA-9717319", "R-HSA-9717323", "R-HSA-9717326", "R-HSA-9717329", "R-HSA-9725370", "R-HSA-9842663", "R-HSA-9851151", "R-MMU-201556", "R-MMU-9842663", "R-MMU-9851151" ]

[ "EC:2.7.10.1", "REACTOME:R-DRE-9842663", "REACTOME:R-HSA-201556", "REACTOME:R-HSA-9700645", "REACTOME:R-HSA-9717264", "REACTOME:R-HSA-9717301", "REACTOME:R-HSA-9717316", "REACTOME:R-HSA-9717319", "REACTOME:R-HSA-9717323", "REACTOME:R-HSA-9717326", "REACTOME:R-HSA-9717329", "REACTOME:R-HSA-9725...

17

[ "7lir", "7lrz", "7ls0", "7mzw", "7mzy", "7n00", "7nwz", "7nx0", "7nx1", "7nx3", "7nx4", "9g5i" ]

12

[ "PUB00100759", "PUB00154890" ]

[ "34646012", "34819665" ]

[ "Structural basis of cytokine-mediated activation of ALK family receptors.", "Structural basis for ligand reception by anaplastic lymphoma kinase." ]

[ 2021, 2021 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "Halobacteriales", "Viruses", "metagenomes" ]

[ 468, 3115, 12, 59, 53 ]

5

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 2, 2, 19, 3, 6 ]

6

true

Domain

ALK/LTK-like, glycine-rich domain

ALK/LTK-like_GRD

3

IPR055164

55,164

EDR1/CTR1/ARMC3-like, peptidase-like domain

EDR1/CTR1/ARMC3-like_pept-like

Domain

8,792

false

This entry represents a peptidase-like domain mainly found in plant proteins, including serine/threonine-protein kinases EDR1 and CTR1 from Arabidopsis thaliana. EDR1 regulates disease resistance and ethylene-induced senescence, and is also involved in stress response signaling and cell death regulation [ , ]. CTR1 act...

[]

0

[ "PFAM" ]

[ "PF14381" ]

[ "EDR1_CTR1_ARMC3_pept" ]

[ 8792 ]

1

[ "EC" ]

[ "2.7.11.1" ]

[ "EC:2.7.11.1" ]

1

[]

0

[ "PUB00061918", "PUB00109660", "PUB00154891", "PUB00154892", "PUB00154893" ]

[ "8431946", "15894742", "23132950", "21605210", "34428398" ]

[ "CTR1, a negative regulator of the ethylene response pathway in Arabidopsis, encodes a member of the raf family of protein kinases.", "Regulation of plant disease resistance, stress responses, cell death, and ethylene signaling in Arabidopsis by the EDR1 protein kinase.", "CTR1 phosphorylates the central regula...

[ 1993, 2005, 2012, 2011, 2021 ]

5

[]

0

null

[ "Eukaryota", "Pseudomonadati" ]

[ 8779, 13 ]

2

[ "Arabidopsis thaliana", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 68, 2, 1, 2, 4, 38, 4, 118 ]

8

true

Domain

EDR1/CTR1/ARMC3-like, peptidase-like domain

EDR1/CTR1/ARMC3-like_pept-like

5

IPR055165

55,165

Flagellar protein FlgA, HotDog domain-like

FlgA_HD-like

Domain

5

false

This domain is found in the flagellar protein FlgA from Thermotoga maritima ( ) and similar sequences from Thermotogales. Its structure has been characterised ( ).

[]

0

[ "PFAM" ]

[ "PF22438" ]

[ "FlgA_HD-like" ]

[ 5 ]

1

[]

0

[ "3frn" ]

1

[]

0

[]

0

null

[ "Thermotoga" ]

[ 5 ]

1

[]

0

true

Domain

Flagellar protein FlgA, HotDog domain-like

FlgA_HD-like

3

IPR055166

55,166

Transcriptional regulator SarA/SarZ/Rot-like, helix-turn-helix domain

Transc_reg_Sar_Rot_HTH

Domain

16,839

false

This entry represents a helix-turn-helix (HTH) domain found in bacterial transcriptional regulatory proteins, including SarA, SarZ and Rot from Staphylococcus aureus [ , , , , ]. Sar is a global regulator with both positive and negative effects that controls expression of several virulence factors and biofilm formation...

[]

0

[ "PFAM" ]

[ "PF22381" ]

[ "Staph_reg_Sar_Rot" ]

[ 16839 ]

1

[]

0

[ "1hsj", "1p4x", "1z91", "1z9c", "2bv6", "2fnp", "2frh", "2pex", "2pfb", "3hrm", "3hse", "3hsr", "4gxo", "4hbl", "4q77", "4rbr", "5hlg", "5hlh", "5hli", "5hs5", "5ywj", "6k8e", "7l19", "9ilk", "9ill" ]

25

[ "PUB00025780", "PUB00029721", "PUB00040748", "PUB00154245", "PUB00154246" ]

[ "11381122", "12837797", "16455801", "25331435", "25195759" ]

[ "Crystal structure of the SarR protein from Staphylococcus aureus.", "Crystal structure of the SarS protein from Staphylococcus aureus.", "Structural and function analyses of the global regulatory protein SarA from Staphylococcus aureus.", "Structure-based functional characterization of repressor of toxin (Ro...

[ 2001, 2003, 2006, 2015, 2014 ]

5

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "metagenomes" ]

[ 78, 16690, 8, 63 ]

4

[]

0

true

Domain

Transcriptional regulator SarA/SarZ/Rot-like, helix-turn-helix domain

Transc_reg_Sar_Rot_HTH

5

IPR055167

55,167

Rootletin-like, coiled-coil

Rootletin-like_CC

Domain

3,278

false

This is a coiled-coil domain found in rootletin (also known as Ciliary rootlet coiled-coil protein, CROCC), CROCC2, the centrosome-associated protein CEP250 and related sequences, involved in centrosome cohesion [ ]. Rootletin is the major structural component of the ciliary rootlet, a cytoskeletal-like structure in ci...

[]

0

[ "PFAM" ]

[ "PF15035" ]

[ "Rootletin" ]

[ 3278 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-2565942", "R-HSA-380259", "R-HSA-380270", "R-HSA-380284", "R-HSA-380320", "R-HSA-5620912", "R-HSA-8854518", "R-MMU-2565942", "R-MMU-380259", "R-MMU-380270", "R-MMU-380284", "R-MMU-380320", "R-MMU-5620912", "R-MMU-8854518" ]

[ "REACTOME:R-HSA-2565942", "REACTOME:R-HSA-380259", "REACTOME:R-HSA-380270", "REACTOME:R-HSA-380284", "REACTOME:R-HSA-380320", "REACTOME:R-HSA-5620912", "REACTOME:R-HSA-8854518", "REACTOME:R-MMU-2565942", "REACTOME:R-MMU-380259", "REACTOME:R-MMU-380270", "REACTOME:R-MMU-380284", "REACTOME:R-MMU...

14

[]

0

[ "PUB00062219", "PUB00094631", "PUB00152443", "PUB00154894", "PUB00154930" ]

[ "16203858", "27623382", "9647649", "30404835", "11076968" ]

[ "Rootletin forms centriole-associated filaments and functions in centrosome cohesion.", "A Conserved Role for Girdin in Basal Body Positioning and Ciliogenesis.", "C-Nap1, a novel centrosomal coiled-coil protein and candidate substrate of the cell cycle-regulated protein kinase Nek2.", "CCDC102B functions in ...

[ 2005, 2016, 1998, 2018, 2000 ]

5

[]

0

null

[ "Eumetazoa" ]

[ 3278 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 7, 21, 1, 20, 8, 7 ]

6

true

Domain

Rootletin-like, coiled-coil

Rootletin-like_CC

4

IPR055168

55,168

Pyruvate-ferredoxin oxidoreductase, insertion domain

Pyruv_OxRed_insertion

Domain

1,065

false

This entry represents the insertion domain of Pyruvate-flavodoxin oxidoreductase from Desulfocurvibacter africanus (Por) and similar bacterial sequences. Por catalyses the ferredoxin-dependent oxidative decarboxylation of pyruvate required for the transfer of electrons from pyruvate to ferredoxin [ , ]. This domain ado...

[]

0

[ "PFAM" ]

[ "PF22338" ]

[ "Pyruv_OxRed_insertion" ]

[ 1065 ]

1

[]

0

[ "1b0p", "1kek", "2c3m", "2c3o", "2c3p", "2c3u", "2c3y", "2c42", "2pda", "2uza", "6cin", "6cio", "6cip", "6ciq", "7plm" ]

15

[ "PUB00074318", "PUB00154189", "PUB00154895" ]

[ "9294422", "29581263", "7612653" ]

[ "Isolation and analysis of the gene encoding the pyruvate-ferredoxin oxidoreductase of Desulfovibrio africanus, production of the recombinant enzyme in Escherichia coli, and effect of carboxy-terminal deletions on its stability.", "Binding site for coenzyme A revealed in the structure of pyruvate:ferredoxin oxido...

[ 1997, 2018, 1995 ]

3

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 942, 96, 27 ]

3

[]

0

true

Domain

Pyruvate-ferredoxin oxidoreductase, insertion domain

Pyruv_OxRed_insertion

7

IPR055169

55,169

Adenylosuccinate lyase, C-terminal domain

ASLyase_C

Domain

21

false

This entry represents the C-terminal helical domain present in the adenylosuccinate lyase from Pyrobaculum aerophilum [ ] and similar archaeal proteins. This domain is remotely related to (Adenylosuccinate lyase C terminus).

[]

0

[ "PFAM" ]

[ "PF22304" ]

[ "ASLyase_C" ]

[ 21 ]

1

[]

0

[ "1dof" ]

1

[ "PUB00024269" ]

[ "10926519" ]

[ "The crystal structure of adenylosuccinate lyase from Pyrobaculum aerophilum reveals an intracellular protein with three disulfide bonds." ]

[ 2000 ]

1

[]

0

null

[ "Filarioidea", "Thermoproteaceae" ]

[ 9, 12 ]

2

[]

0

true

Domain

Adenylosuccinate lyase, C-terminal domain

ASLyase_C

3

IPR055171

55,171

GT-D fold-like domain

GT-D-like

Domain

446

false

This domain is related to the GT-D fold glycosyltransferase domain ( ). These protein domains share a common sequence motif R[VIL]GDGE, significant structural similarity based on the predicted AF2 model, but low sequence similarity. This domain is found standalone and in combination with other domains in a number of pr...

[]

0

[ "PFAM" ]

[ "PF22882" ]

[ "GT-D-like" ]

[ 446 ]

1

[]

0

[]

0

[]

0

[]

[ "IPR049785" ]

0

1

0

[ "Bacteria", "metagenomes" ]

[ 439, 7 ]

2

[]

0

true

Domain

GT-D fold-like domain

GT-D-like

4

IPR055172

55,172

RsaL-like, HTH domain

HTH_RsaL-like

Domain

641

false

This is a helix-turn-helix (HTH) domain found in quorum-sensing regulator RsaL ( ) from Pseudomonas aeruginosa and related proteins [ ]. RsaL is a QS repressor that reduces QS signal production and ensures homeostasis by functioning in opposition to LasR [ ].

[]

0

[ "PFAM" ]

[ "PF22495" ]

[ "HTH_92" ]

[ 641 ]

1

[]

0

[ "5j2y" ]

1

[ "PUB00154897" ]

[ "27924027" ]

[ "Crystal structure of Pseudomonas aeruginosa RsaL bound to promoter DNA reaffirms its role as a global regulator involved in quorum-sensing." ]

[ 2017 ]

1

[ "IPR001387" ]

[]

1

0

1

[ "Caudoviricetes", "Pseudomonadati", "ecological metagenomes" ]

[ 23, 614, 4 ]

3

[]

0

true

Domain

RsaL-like, HTH domain

HTH_RsaL-like

9

IPR055173

55,173

Transcriptional repressor NrdR-like, N-terminal domain

NrdR-like_N

Domain

19,307

false

This entry represents the N-terminal domain of the Transcriptional repressor NrdR and similar sequences, which is a zinc β-ribbon domain, followed by an ATP-cone domain ( ) [ ]. These proteins negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes. This d...

[]

0

[ "PFAM" ]

[ "PF22811" ]

[ "Zn_ribbon_NrdR" ]

[ 19307 ]

1

[]

0

[ "7p37", "7p3f", "7p3q", "9fvr", "9fxk", "9fzf" ]

6

[ "PUB00154118" ]

[ "35577776" ]

[ "A nucleotide-sensing oligomerization mechanism that controls NrdR-dependent transcription of ribonucleotide reductases." ]

[ 2022 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 56, 18851, 21, 29, 350 ]

5

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Domain

Transcriptional repressor NrdR-like, N-terminal domain

NrdR-like_N

7

IPR055174

55,174

Pus10, THUMP domain, archaeal

Pus10_THUMP_arc

Domain

922

false

This entry represents the THUMP domain found in Pus10 proteins from archaea. Pus10 is a tRNA pseudouridine synthase responsible for the synthesis of pseudouridine from uracil-54 and uracil-55 in the psi GC loop of transfer RNAs [ , ].

[]

0

[ "PFAM" ]

[ "PF22023" ]

[ "Pus10_THUMP_arc" ]

[ 922 ]

1

[ "EC" ]

[ "5.4.99.25" ]

[ "EC:5.4.99.25" ]

1

[]

0

[ "PUB00056793", "PUB00090269", "PUB00154188" ]

[ "18952823", "29349599", "36833309" ]

[ "Archaeal Pus10 proteins can produce both pseudouridine 54 and 55 in tRNA.", "Evolution of Eukaryal and Archaeal Pseudouridine Synthase Pus10.", "Transfer RNA Modification Enzymes with a Thiouridine Synthetase, Methyltransferase and Pseudouridine Synthase (THUMP) Domain and the Nucleosides They Produce in tRNA....

[ 2008, 2018, 2023 ]

3

[]

0

null

[ "Archaea", "Bacteria", "unclassified sequences" ]

[ 884, 5, 33 ]

3

[]

0

true

Domain

Pus10, THUMP domain, archaeal

Pus10_THUMP_arc

8

IPR055175

55,175

ACK/TNK-like, SAM domain

ACK/TNK-like_SAM

Domain

4,391

false

This entry represents the SAM (sterile alpha motif) domain of ACK/TNK-like subfamily of non-receptor tyrosine-protein kinases. It is usually located at the N terminus and is followed by the catalytic domain and a number of other domains. This is a putative protein-protein interaction domain [ ].

[]

0

[ "PFAM" ]

[ "PF22931" ]

[ "SAM_TNK" ]

[ 4391 ]

1

[ "EC", "EC", "REACTOME", "REACTOME", "REACTOME" ]

[ "2.7.10.2", "2.7.11.1", "R-HSA-9842663", "R-MMU-9842663", "R-RNO-9842663" ]

[ "EC:2.7.10.2", "EC:2.7.11.1", "REACTOME:R-HSA-9842663", "REACTOME:R-MMU-9842663", "REACTOME:R-RNO-9842663" ]

5

[]

0

[ "PUB00154287" ]

[ "36980241" ]

[ "Domain Architecture of the Nonreceptor Tyrosine Kinase Ack1." ]

[ 2023 ]

1

[]

[ "IPR049587" ]

0

1

0

[ "Eukaryota" ]

[ 4391 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 15, 4, 17, 16, 13 ]

6

true

Domain

ACK/TNK-like, SAM domain

ACK/TNK-like_SAM

6

IPR055176

55,176

UBP24/USP9X/USP9Y, ubiquitin-like domain

UBP24/USP9X/USP9Y_UBL

Domain

3,526

false

This entry represents a Ubiquitin-like domain found in a ubiquitin carboxyl-terminal hydrolases, such as UBP24, USP9X and USP9Y from human and its orthologue from Drosophila, the probable ubiquitin carboxyl-terminal hydrolase FAF. UCHs are thiol proteases that recognise and hydrolyse the peptide bond at the C-terminal ...

[]

0

[ "PFAM" ]

[ "PF22900" ]

[ "UCH_UBL1" ]

[ 3526 ]

1

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "3.4.19.12", "R-DME-2173795", "R-DME-5689880", "R-DME-8866652", "R-DME-9013420", "R-DME-9013424", "R-DME-9033241", "R-HSA-2173795", "R-HSA-5689880", "R-HSA-8866652", "R-HSA-9013420", "R-HSA-9013424", "R-HSA-9033241", "R-HSA-977225", "R-MMU-2173795", "R-MMU-5689880", "R-MMU-8866652", ...

[ "EC:3.4.19.12", "REACTOME:R-DME-2173795", "REACTOME:R-DME-5689880", "REACTOME:R-DME-8866652", "REACTOME:R-DME-9013420", "REACTOME:R-DME-9013424", "REACTOME:R-DME-9033241", "REACTOME:R-HSA-2173795", "REACTOME:R-HSA-5689880", "REACTOME:R-HSA-8866652", "REACTOME:R-HSA-9013420", "REACTOME:R-HSA-90...

20

[ "5vbd", "7yxx", "7yxy" ]

3

[ "PUB00045907", "PUB00069571", "PUB00078669", "PUB00095288", "PUB00132877", "PUB00154898", "PUB00154899", "PUB00154900", "PUB00154901" ]

[ "19135894", "23845989", "23159851", "29695420", "18254724", "12895410", "22371489", "30914461", "37454738" ]

[ "FAM/USP9x, a deubiquitinating enzyme essential for TGFbeta signaling, controls Smad4 monoubiquitination.", "Regulation of proteolysis by human deubiquitinating enzymes.", "The deubiquitinating protein USP24 interacts with DDB2 and regulates DDB2 stability.", "Human Cytomegalovirus Protein pUL38 Prevents Prem...

[ 2009, 2014, 2012, 2018, 2008, 2003, 2012, 2019, 2023 ]

9

[]

[ "IPR047061" ]

0

1

0

[ "Eukaryota" ]

[ 3526 ]

1

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 9, 3, 9, 5, 9 ]

5

true

Domain

UBP24/USP9X/USP9Y, ubiquitin-like domain

UBP24/USP9X/USP9Y_UBL

4

IPR055177

55,177

UPF0425 pyridoxal phosphate-dependent protein MJ0158-like, C-terminal domain

UPF0425_MJ0158-like_C

Domain

98

false

This entry represents the C-terminal domain of UPF0425 pyridoxal phosphate-dependent protein MJ0158 from Methanocaldococcus jannaschii [ ] and similar sequences mainly found in archaea.

[]

0

[ "PFAM" ]

[ "PF22583" ]

[ "UPF0425_C" ]

[ 98 ]

1

[]

0

[ "2aeu", "2aev" ]

2

[ "PUB00039259" ]

[ "16201757" ]

[ "Structural and functional investigation of a putative archaeal selenocysteine synthase." ]

[ 2005 ]

1

[]

0

null

[ "Bacteria", "Methanomada group", "bioreactor metagenome" ]

[ 2, 95, 1 ]

3

[]

0

true

Domain

UPF0425 pyridoxal phosphate-dependent protein MJ0158-like, C-terminal domain

UPF0425_MJ0158-like_C

2

IPR055178

55,178

RsdA/BaiN/AoA(So)-like, insert domain

RsdA/BaiN/AoA(So)-like_dom

Domain

24,344

false

This entry represents two structural (β-barrel and H2TH α-helical) domains that are found inserted within a Rossmann fold-like domain . This domain is found in 3-dehydro-bile acid delta(4,6)-reductase from Clostridium scindens (BaiN), Ribosomal RNA dihydrouridine synthase (rdsA) from Escherichia coli and Aminoacetone o...

[]

0

[ "PFAM" ]

[ "PF22780" ]

[ "HI0933_like_1st" ]

[ 24344 ]

1

[]

0

[ "2gqf", "2i0z", "3v76", "4cnj", "4cnk" ]

5

[ "PUB00090979", "PUB00106457", "PUB00160761", "PUB00160762", "PUB00160763" ]

[ "29217478", "25269103", "18469105", "22666463", "39078675" ]

[ "Identification of a gene encoding a flavoprotein involved in bile acid metabolism by the human gut bacterium Clostridium scindens ATCC 35704.", "Aminoacetone oxidase from Streptococcus oligofermentans belongs to a new three-domain family of bacterial flavoproteins.", "SO-LAAO, a novel L-amino acid oxidase that...

[ 2018, 2014, 2008, 2012, 2024 ]

5

[]

0

null

[ "Bacteria", "Eukaryota", "Methanobacteriota", "unclassified sequences" ]

[ 23209, 809, 95, 231 ]

4

[ "Arabidopsis thaliana", "Escherichia coli (strain K12)", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 10, 1, 5, 7 ]

4

true

Domain

RsdA/BaiN/AoA(So)-like, insert domain

RsdA/BaiN/AoA(So)-like_dom

3

IPR055179

55,179

Tex-like, central region

Tex-like_central_region

Domain

25,236

false

This domain is found in the transcriptional accessory protein Tex protein from Bordetella pertussis, in the human and yeast transcription elongation factor SPT6 and in similar sequences maily from bacteria and eukaryotes. Tex belongs to a family of prokaryotic transcriptional accessory factors that likely function in a...

[]

0

[ "PFAM" ]

[ "PF22706" ]

[ "Tex_central_region" ]

[ 25236 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-CEL-112382", "R-CEL-674695", "R-CEL-75955", "R-DME-112382", "R-DME-674695", "R-DME-75955", "R-HSA-112382", "R-HSA-674695", "R-HSA-75955", "R-MMU-112382", "R-MMU-674695", "R-MMU-75955" ]

[ "REACTOME:R-CEL-112382", "REACTOME:R-CEL-674695", "REACTOME:R-CEL-75955", "REACTOME:R-DME-112382", "REACTOME:R-DME-674695", "REACTOME:R-DME-75955", "REACTOME:R-HSA-112382", "REACTOME:R-HSA-674695", "REACTOME:R-HSA-75955", "REACTOME:R-MMU-112382", "REACTOME:R-MMU-674695", "REACTOME:R-MMU-75955"...

12

[ "2oce", "3bzc", "3bzk", "3psf", "3psi", "6gmh", "6ted", "7o3d", "7o6b", "7oop", "7opc", "7opd", "7unc", "7und", "7xn7", "7xse", "7xsx", "7xsz", "7xt7", "7xtd", "7xti", "8a3y", "8oeu", "8oev", "8of0", "8xrm", "9egx", "9egy", "9egz", "9eh0", "9eh1", "9eh2"...

39

[ "PUB00050835", "PUB00065554", "PUB00154273", "PUB00154274", "PUB00154275", "PUB00154902", "PUB00154903", "PUB00154904" ]

[ "18321528", "21419780", "30135578", "32541898", "34526721", "15060154", "23503590", "9514752" ]

[ "Crystal structure and RNA binding of the Tex protein from Pseudomonas aeruginosa.", "Crystal structures of the S. cerevisiae Spt6 core and C-terminal tandem SH2 domain.", "Structure of activated transcription complex Pol II-DSIF-PAF-SPT6.", "Structure of complete Pol II-DSIF-PAF-SPT6 transcription complex re...

[ 2008, 2011, 2018, 2020, 2021, 2004, 2013, 1998 ]

8

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 65, 19472, 5573, 126 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus", "Saccharomyces cerevisiae (stra...

[ 10, 1, 9, 4, 1, 3, 3, 1, 10, 1, 1 ]

11

true

Domain

Tex-like, central region

Tex-like_central_region

8

IPR055180

55,180

Restriction endonuclease, type I, HsdR, second RecA-like helicase domain

HsdR_RecA-like_helicase_dom_2

Domain

18,777

false

This entry represents the second RecA-like helicase domain (the third domain) found in a restriction (R) subunit (HsdR) of a number of type I restriction enzymes, including the Type I restriction enzyme EcoR124I/EcoR124II endonuclease subunit from Escherichia coli [ ]. Subunit R is required for both nuclease and ATPase...

[]

0

[ "PFAM" ]

[ "PF22679" ]

[ "T1R_D3-like" ]

[ 18777 ]

1

[ "EC" ]

[ "3.1.21.3" ]

[ "EC:3.1.21.3" ]

1

[ "2w00", "4be7", "4beb", "4bec", "4xjx", "6h2j", "7bst", "7bto", "7btp", "7btq", "7btr" ]

11

[ "PUB00049980", "PUB00099965" ]

[ "19079266", "12654995" ]

[ "Structure of the motor subunit of type I restriction-modification complex EcoR124I.", "A nomenclature for restriction enzymes, DNA methyltransferases, homing endonucleases and their genes." ]

[ 2009, 2003 ]

2

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 483, 17928, 145, 4, 217 ]

5

[]

0

true

Domain

Restriction endonuclease, type I, HsdR, second RecA-like helicase domain

HsdR_RecA-like_helicase_dom_2

6

IPR055181

55,181

FGAR-AT, PurM N-terminal-like domain

FGAR-AT_PurM_N-like

Domain

13,904

false

This entry represents the PurM_N-like domain of Phosphoribosylformylglycinamidine synthase from Schizosaccharomyces pombe (FGAR-AT) and related proteins from eukaryotes and bacteria. FGAR-AT catalyses the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) to formylglycinamidine ribonucleotide (FGAM) in...

[]

0

[ "PFAM" ]

[ "PF22689" ]

[ "FGAR-AT_PurM_N-like" ]

[ 13904 ]

1

[ "EC", "METACYC", "METACYC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "6.3.5.3", "PWY-6121", "PWY-6122", "PWY-6277", "R-CEL-73817", "R-DDI-73817", "R-DME-73817", "R-HSA-73817", "R-MMU-73817", "R-SCE-73817", "R-SPO-73817" ]

[ "EC:6.3.5.3", "METACYC:PWY-6121", "METACYC:PWY-6122", "METACYC:PWY-6277", "REACTOME:R-CEL-73817", "REACTOME:R-DDI-73817", "REACTOME:R-DME-73817", "REACTOME:R-HSA-73817", "REACTOME:R-MMU-73817", "REACTOME:R-SCE-73817", "REACTOME:R-SPO-73817" ]

11

[ "1t3t", "3ugj", "3ujn", "3umm", "4l78", "4lgy", "4mgh", "4r7g", "6jt7", "6jt8", "6jt9", "6jta", "6lyk", "6lyl", "6lym", "6lyo", "7dw7" ]

17

[ "PUB00037958", "PUB00041488", "PUB00043267", "PUB00051253", "PUB00058401" ]

[ "16544324", "17154526", "17612488", "18597481", "22081394" ]

[ "Crystal structure of phosphoribosylformylglycinamidine synthase II (smPurL) from Thermotoga maritima at 2.15 A resolution.", "Complexed structures of formylglycinamide ribonucleotide amidotransferase from Thermotoga maritima describe a novel ATP binding protein superfamily.", "Crystal structures of [NiFe] hydr...

[ 2006, 2006, 2007, 2008, 2012 ]

5

[]

0

null

[ "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 9387, 4322, 56, 139 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus",...

[ 5, 1, 1, 1, 1, 6, 1, 1, 5, 2, 1, 1, 11 ]

13

true

Domain

FGAR-AT, PurM N-terminal-like domain

FGAR-AT_PurM_N-like

6

IPR055183

55,183

PTEN2A/B, C2 domain

PTEN2A/B_C2

Domain

1,223

false

This entry represents a C2 domain found in PTEN2A (Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and protein-tyrosine-phosphatase) and PTEN2B from plants. These proteins are tyrosine phosphatases that exhibit also a weak lipid phosphatase activity towards PtdIns3P [ ].

[]

0

[ "PFAM" ]

[ "PF22918" ]

[ "PTEN2_C2" ]

[ 1223 ]

1

[]

0

[]

0

[ "PUB00154907" ]

[ "21864294" ]

[ "A novel class of PTEN protein in Arabidopsis displays unusual phosphoinositide phosphatase activity and efficiently binds phosphatidic acid." ]

[ 2012 ]

1

[ "IPR014020" ]

[]

1

0

1

[ "Viridiplantae" ]

[ 1223 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 8, 7, 7 ]

3

true

Domain

PTEN2A/B, C2 domain

PTEN2A/B_C2

2

IPR055184

55,184

COMMD8, helical N-terminal domain

COMMD8_HN

Domain

1,168

false

This entry represents the α-helical N-terminal domain (HN) of COMMD8, one of the subunits of the CCC complex (Commander complex), which regulates the Retromer-independent retrieval and recycling of hundreds of proteins including integrins and lipoprotein receptors [ ].

[]

0

[ "PFAM" ]

[ "PF22838" ]

[ "COMMD8_HN" ]

[ 1168 ]

1

[ "REACTOME", "REACTOME", "REACTOME" ]

[ "R-DDI-8951664", "R-HSA-8951664", "R-MMU-8951664" ]

[ "REACTOME:R-DDI-8951664", "REACTOME:R-HSA-8951664", "REACTOME:R-MMU-8951664" ]

3

[ "8f2r", "8f2u", "8p0w" ]

3

[ "PUB00153880" ]

[ "37172566" ]

[ "Structure of the endosomal Commander complex linked to Ritscher-Schinzel syndrome." ]

[ 2023 ]

1

[]

0

null

[ "Eukaryota" ]

[ 1168 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 1, 3, 4 ]

4

true

Domain

COMMD8, helical N-terminal domain

COMMD8_HN

6

IPR055185

55,185

BIRD-IDD transcription factor, fourth C2HC zinc finger

C2CH-4th_BIRD-IDD

Domain

8,981

false

This C2HC zinc finger domain is found in the plant BIRD/INDETERMINATE DOMAIN (IDD) transcription factor family. Members of this BIRD/IDD family such as JACKDAW (JKD)/IDD10, BALDIBIS (BIB), MAGPIE (MGP)/IDD3 are required for asymmetric cell division of ground tissue and QC specification by direct protein-protein interac...

[]

0

[ "PFAM" ]

[ "PF22992" ]

[ "C2CH-4th_BIRD-IDD" ]

[ 8981 ]

1

[]

0

[ "5b3h" ]

1

[ "PUB00101451" ]

[ "28211915" ]

[ "Structure of the SHR-SCR heterodimer bound to the BIRD/IDD transcriptional factor JKD." ]

[ 2017 ]

1

[]

0

null

[ "Eukaryota" ]

[ 8981 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 66, 34, 75 ]

3

true

Domain

BIRD-IDD transcription factor, fourth C2HC zinc finger

C2CH-4th_BIRD-IDD

9

IPR055186

55,186

BIRD-IDD transcription factor, second C2H2 zinc finger

C2H2-2nd_BIRD-IDD

Domain

9,894

false

This C2H2 zinc finger domain is found in the plant BIRD/INDETERMINATE DOMAIN (IDD) transcription factor family. Members of this BIRD/IDD family such as JACKDAW (JKD)/IDD10, BALDIBIS (BIB), MAGPIE (MGP)/IDD3 are required for asymmetric cell division of ground tissue and QC specification by direct protein-protein interac...

[]

0

[ "PFAM" ]

[ "PF22996" ]

[ "C2H2-2nd_BIRD-IDD" ]

[ 9894 ]

1

[]

0

[]

0

[ "PUB00101451" ]

[ "28211915" ]

[ "Structure of the SHR-SCR heterodimer bound to the BIRD/IDD transcriptional factor JKD." ]

[ 2017 ]

1

[ "IPR013087" ]

[]

1

0

1

[ "Streptophyta" ]

[ 9894 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 73, 41, 85 ]

3

true

Domain

BIRD-IDD transcription factor, second C2H2 zinc finger

C2H2-2nd_BIRD-IDD

2

IPR055187

55,187

BIRD-IDD transcription factor, third C2HC zinc finger

C2CH-3rd_BIRD-IDD

Domain

13,588

false

This C2HC zinc finger domain is found in the plant BIRD/INDETERMINATE DOMAIN (IDD) transcription factor family. Members of this BIRD/IDD family such as JACKDAW (JKD)/IDD10, BALDIBIS (BIB), MAGPIE (MGP)/IDD3 are required for asymmetric cell division of ground tissue and QC specification by direct protein-protein interac...

[]

0

[ "PFAM" ]

[ "PF22995" ]

[ "C2CH-3rd_BIRD-IDD" ]

[ 13588 ]

1

[]

0

[ "5b3h" ]

1

[ "PUB00101451" ]

[ "28211915" ]

[ "Structure of the SHR-SCR heterodimer bound to the BIRD/IDD transcriptional factor JKD." ]

[ 2017 ]

1

[ "IPR013087" ]

[]

1

0

1

[ "Eukaryota" ]

[ 13588 ]

1

[ "Arabidopsis thaliana", "Mus musculus", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 98, 1, 66, 104 ]

4

true

Domain

BIRD-IDD transcription factor, third C2HC zinc finger

C2CH-3rd_BIRD-IDD

1

IPR055188

55,188

Choice-of-anchor I domain

Choice_anch_I

Domain

5,610

false

This entry represents the choice-of-anchor I domain, found in the alkaline phosphatase PhoA of Synechocystis sp. PCC 6803 ( ), upstream of the region presumed to have phosphatase activity. It is also found in Mesenchyme-specific cell surface glycoprotein from Strongylocentrotus purpuratus that is likely involved in in ...

[]

0

[ "PFAM" ]

[ "PF22494" ]

[ "choice_anch_I" ]

[ 5610 ]

1

[]

0

[ "1l0q" ]

1

[ "PUB00154932" ]

[ "2295637" ]

[ "Promoter structure and protein sequence of msp130, a lipid-anchored sea urchin glycoprotein." ]

[ 1990 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "Kyanoviridae", "Methanobacteriati", "metagenomes" ]

[ 4946, 545, 3, 81, 35 ]

5

[]

0

true

Domain

Choice-of-anchor I domain

Choice_anch_I

9

IPR055189

55,189

Large ribosomal subunit protein mL44, endonuclease domain

RM44_endonuclase

Domain

1,863

false

Large ribosomal subunit protein mL44 (RM44) is a component of the 39S subunit of mitochondrial ribosome. It may play a role in the assembly/stability of nascent mitochondrial polypeptides exiting the ribosome. This entry represents the endonuclease (RNase III-like) domain of RM44 [ , , ].

[]

0

[ "PFAM" ]

[ "PF22935" ]

[ "RM44_endonuclase" ]

[ 1863 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-CEL-5389840", "R-CEL-5419276", "R-CEL-9937383", "R-HSA-5368286", "R-HSA-5389840", "R-HSA-5419276", "R-HSA-9937383", "R-MMU-5389840", "R-MMU-5419276", "R-MMU-9937383" ]

[ "REACTOME:R-CEL-5389840", "REACTOME:R-CEL-5419276", "REACTOME:R-CEL-9937383", "REACTOME:R-HSA-5368286", "REACTOME:R-HSA-5389840", "REACTOME:R-HSA-5419276", "REACTOME:R-HSA-9937383", "REACTOME:R-MMU-5389840", "REACTOME:R-MMU-5419276", "REACTOME:R-MMU-9937383" ]

10

[ "3j7y", "3j9m", "4ce4", "4v1a", "5aj4", "5ool", "5oom", "6gaw", "6gb2", "6i9r", "6nu2", "6nu3", "6vlz", "6vmi", "6ydp", "6ydw", "6zm5", "6zm6", "6zs9", "6zsa", "6zsb", "6zsc", "6zsd", "6zse", "6zsg", "7a5f", "7a5g", "7a5h", "7a5i", "7a5j", "7a5k", "7l08"...

91

[ "PUB00089007", "PUB00108679", "PUB00108680" ]

[ "25278503", "24362565", "25271403" ]

[ "Structure of the large ribosomal subunit from human mitochondria.", "Architecture of the large subunit of the mammalian mitochondrial ribosome.", "The complete structure of the large subunit of the mammalian mitochondrial ribosome." ]

[ 2014, 2014, 2014 ]

3

[]

0

null

[ "Opisthokonta" ]

[ 1863 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 1, 2, 1, 3, 2 ]

6

true

Domain

Large ribosomal subunit protein mL44, endonuclease domain

RM44_endonuclase

8

IPR055191

55,191

DNA polymerase epsilon ,catalytic subunit A, thumb domain

POL2_thumb

Domain

4,894

false

This entry represents the thumb domain of DNA polymerase epsilon catalytic subunit A from Saccharomyces cerevisiae (POL2) and its homologues from eukaryotes. This domain, which makes contacts in the DNA minor groove, shows a mainly α-helical structure [ ]. The catalytic component of the DNA polymerase epsilon complex i...

[]

0

[ "PFAM" ]

[ "PF22634" ]

[ "POL2_thumb" ]

[ 4894 ]

1

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", ...

[ "2.7.7.7", "R-DDI-110314", "R-DDI-5651801", "R-DDI-5656169", "R-DDI-5696397", "R-DDI-6782135", "R-DDI-6782210", "R-DDI-68952", "R-DDI-68962", "R-DME-110314", "R-DME-5651801", "R-DME-5656169", "R-DME-5696400", "R-DME-6782135", "R-DME-68952", "R-DME-68962", "R-HSA-110314", "R-HSA-565...

[ "EC:2.7.7.7", "REACTOME:R-DDI-110314", "REACTOME:R-DDI-5651801", "REACTOME:R-DDI-5656169", "REACTOME:R-DDI-5696397", "REACTOME:R-DDI-6782135", "REACTOME:R-DDI-6782210", "REACTOME:R-DDI-68952", "REACTOME:R-DDI-68962", "REACTOME:R-DME-110314", "REACTOME:R-DME-5651801", "REACTOME:R-DME-5656169", ...

49

[ "4m8o", "4ptf", "6fwk", "6g0a", "6h1v", "6i8a", "6qib", "6s2e", "6s2f", "6wjv", "7pfo", "7plo", "7pmk", "7pmn", "7qhs", "7r3x", "7r3y", "7z13", "8b67", "8b6k", "8b76", "8b77", "8b79", "8b7e", "8kg6", "8kg8", "8kg9", "8p5e", "8p62", "8p63", "8tw9", "8twa"...

48

[ "PUB00070663", "PUB00070664", "PUB00154171", "PUB00154172", "PUB00154173" ]

[ "24292646", "24733111", "30670696", "30968138", "32585006" ]

[ "Structural basis for processive DNA synthesis by yeast DNA polymerase ɛ.", "Crystal structure of yeast DNA polymerase ε catalytic domain.", "Structural consequence of the most frequently recurring cancer-associated substitution in DNA polymerase ε.", "Structural evidence for an essential Fe-S cluster in the ...

[ 2014, 2014, 2019, 2019, 2020 ]

5

[]

0

null

[ "Eukaryota" ]

[ 4894 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 13, 1, 1, 3, 7, 5, 1, 3, 3, 1, 1, 20 ]

12

true

Domain

DNA polymerase epsilon ,catalytic subunit A, thumb domain

POL2_thumb

7

IPR055192

55,192

Proline-rich AKT1 substrate 1, N-terminal domain

PRAS_NT

Domain

567

false

This entry represents a domain found in the N-terminal of the PRAS (Proline-rich AKT1 substrate 1) family [ , , , ]. PRAS is a proline-rich protein that can be phosphorylated by AKT, and in the phosphorylated state binds to 14-3-3. The AKT signalling pathway contributes to regulation of apoptosis after a variety of cel...

[]

0

[ "PFAM" ]

[ "PF22911" ]

[ "PRAS_NT" ]

[ 567 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-165159", "R-HSA-166208", "R-HSA-198323", "R-HSA-3371571", "R-HSA-5674400", "R-MMU-165159", "R-MMU-166208", "R-MMU-198323", "R-MMU-3371571" ]

[ "REACTOME:R-HSA-165159", "REACTOME:R-HSA-166208", "REACTOME:R-HSA-198323", "REACTOME:R-HSA-3371571", "REACTOME:R-HSA-5674400", "REACTOME:R-MMU-165159", "REACTOME:R-MMU-166208", "REACTOME:R-MMU-198323", "REACTOME:R-MMU-3371571" ]

9

[ "6sb0" ]

1

[ "PUB00061636", "PUB00061637", "PUB00061638", "PUB00154179" ]

[ "17277771", "14973226", "16397181", "31601764" ]

[ "Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40.", "Neuroprotective role of a proline-rich Akt substrate in apoptotic neuronal cell death after stroke: relationships with nerve growth factor.", "Modulation of proline-rich akt substrate survival signaling pathways by oxidative stress in mous...

[ 2007, 2004, 2006, 2019 ]

4

[]

0

null

[ "Vertebrata" ]

[ 567 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 3, 3, 8, 8 ]

4

true

Domain

Proline-rich AKT1 substrate 1, N-terminal domain

PRAS_NT

6

IPR055194

55,194

E3 ubiquitin-protein ligase UBR1-like, winged-helix domain

UBR1-like_WH

Domain

8,949

false

This entry represents the winged-helix domain of E3 ubiquitin-protein ligase UBR1/2/3 and the plant homologue PRT6. These E3 ubiquitin-protein ligases recognise and bind to proteins bearing specific N-terminal residues that are destabilising according to the N-end rule, leading to their ubiquitination and subsequent de...

[]

0

[ "PFAM" ]

[ "PF22960" ]

[ "WHD_UBR1" ]

[ 8949 ]

1

[ "EC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "2.3.2.27", "PWY-7511", "R-CEL-983168", "R-DME-983168", "R-HSA-983168", "R-MMU-983168", "R-SCE-983168", "R-SPO-983168" ]

[ "EC:2.3.2.27", "METACYC:PWY-7511", "REACTOME:R-CEL-983168", "REACTOME:R-DME-983168", "REACTOME:R-HSA-983168", "REACTOME:R-MMU-983168", "REACTOME:R-SCE-983168", "REACTOME:R-SPO-983168" ]

8

[ "7mex", "7mey" ]

2

[ "PUB00089034", "PUB00103365", "PUB00154933" ]

[ "27195754", "28392261", "34789879" ]

[ "Ubr3, a Novel Modulator of Hh Signaling Affects the Degradation of Costal-2 and Kif7 through Poly-ubiquitination.", "Bound Waters Mediate Binding of Diverse Substrates to a Ubiquitin Ligase.", "Structural insights into Ubr1-mediated N-degron polyubiquitination." ]

[ 2016, 2017, 2021 ]

3

[]

0

null

[ "Eukaryota" ]

[ 8949 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizo...

[ 5, 2, 17, 4, 10, 9, 2, 12, 2, 2, 9 ]

11

true

Domain

E3 ubiquitin-protein ligase UBR1-like, winged-helix domain

UBR1-like_WH

9

IPR055195

55,195

Integrator complex subunit 7-like, C-terminal domain, plant

INTS7_C_plant

Domain

653

false

This entry represents a C-terminal domain found in the putative Integrator complex subunit 7 (INTS7) from plants. INTS7 is a component of the integrator complex, a complex that is recruited to the U1 and U2 snRNA genes and mediates the snRNAs' 3' end processing. The integrator complex interacts with the C-terminal tail...

[]

0

[ "PFAM" ]

[ "PF22966" ]

[ "INTS7_C_plants" ]

[ 653 ]

1

[]

0

[]

0

[ "PUB00154024" ]

[ "27427483" ]

[ "Integrator complex and transcription regulation: Recent findings and pathophysiology." ]

[ 2016 ]

1

[]

0

null

[ "Embryophyta" ]

[ 653 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 6, 2, 14 ]

3

true

Domain

Integrator complex subunit 7-like, C-terminal domain, plant

INTS7_C_plant

1

IPR055196

55,196

Pyridoxamine 5'-phosphate oxidase-like

Putative_PNPOx_2

Domain

383

false

This domain is found in bacterial Pyridoxamine 5'-phosphate oxidase-like proteins. It folds into a β-barrel capped at the top and bottom with α-helices.

[]

0

[ "PFAM" ]

[ "PF22696" ]

[ "Putative_PNPOx_2" ]

[ 383 ]

1

[]

0

[ "3ba3" ]

1

[]

0

[]

0

null

[ "Bacteria", "Methanimicrococcus", "Ranatra chinensis", "bioreactor metagenome" ]

[ 372, 4, 1, 6 ]

4

[]

0

true

Domain

Pyridoxamine 5'-phosphate oxidase-like

Putative_PNPOx_2

1

IPR055197

55,197

Histone-lysine N-methyltransferase NSD-like, variant PHD zinc finger

PHDvar_NSD

Domain

4,925

false

This domain is found in the NSD (nuclear receptor SET domain- containing) family of histone-lysine N-methyltransferase such as NSD1, NSD2, NSD3 and other related proteins [ ]. It is a variant of the classical PHD zinc finger containing a C4HC2H zinc finger-like motif which is distinct from the typical C4HC3 motif.

[]

0

[ "PFAM" ]

[ "PF23004" ]

[ "PHDvar_NSD" ]

[ 4925 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-3214841", "R-HSA-5693565", "R-HSA-5693571", "R-HSA-5693607", "R-HSA-69473", "R-MMU-3214841", "R-MMU-5693565", "R-MMU-5693571", "R-MMU-5693607", "R-MMU-69473" ]

[ "REACTOME:R-HSA-3214841", "REACTOME:R-HSA-5693565", "REACTOME:R-HSA-5693571", "REACTOME:R-HSA-5693607", "REACTOME:R-HSA-69473", "REACTOME:R-MMU-3214841", "REACTOME:R-MMU-5693565", "REACTOME:R-MMU-5693571", "REACTOME:R-MMU-5693607", "REACTOME:R-MMU-69473" ]

10

[ "7cro", "7crp", "7crq", "7crr" ]

4

[ "PUB00154120" ]

[ "33361816" ]

[ "Molecular basis of nucleosomal H3K36 methylation by NSD methyltransferases." ]

[ 2021 ]

1

[ "IPR001965" ]

[ "IPR047429", "IPR047441" ]

1

2

0

[ "Eukaryota" ]

[ 4925 ]

1

[ "Arabidopsis thaliana", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 16, 33, 2, 9, 8, 3, 7, 10 ]

8

true

Domain

Histone-lysine N-methyltransferase NSD-like, variant PHD zinc finger

PHDvar_NSD

2

IPR055199

55,199

Hda, lid domain

Hda_lid

Domain

7,825

false

This entry represents the lid domain found at the C-terminal of the Regulatory inactivation of DnaA Hda protein from Shewanella amazonensis, the essential component of RIDA (regulatory inactivation of DnaA), and related proteins predominantly from proteobacteria. This domain is a short four-helical bundle that contains...

[]

0

[ "PFAM" ]

[ "PF22688" ]

[ "Hda_lid" ]

[ 7825 ]

1

[]

0

[ "3bos", "3sc3", "5x06" ]

3

[ "PUB00050713" ]

[ "19000695" ]

[ "A structural basis for the regulatory inactivation of DnaA." ]

[ 2009 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 7695, 8, 122 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Domain

Hda, lid domain

Hda_lid

6

IPR055201

55,201

Integration host factor-like, helix-two turn-helix domain

IHF-like_H2TH

Domain

5,011

false

This entry represents helix-two turn-helix (H2TH) domains found in Integration host factor from Streptomyces coelicolor (IHF) and similar proteins mainly found in actinomycetes. IHF is a nucleoid-associated protein (NAP) that probably plays a role in chromosome compactation. It contributes to development and secondary ...

[]

0

[ "PFAM" ]

[ "PF22525" ]

[ "H2TH_5" ]

[ 5011 ]

1

[]

0

[ "4itq", "6bek", "6tob" ]

3

[ "PUB00065099", "PUB00151044", "PUB00154908" ]

[ "23427309", "31376411", "22038127" ]

[ "A novel nucleoid-associated protein specific to the actinobacteria.", "Streptomyces IHF uses multiple interfaces to bind DNA.", "A novel function of Streptomyces integration host factor (sIHF) in the control of antibiotic production and sporulation in Streptomyces coelicolor." ]

[ 2013, 2019, 2012 ]

3

[]

0

null

[ "Bacteria", "Caudoviricetes", "Rhynchospora breviuscula", "metagenomes" ]

[ 4821, 5, 1, 184 ]

4

[]

0

true

Domain

Integration host factor-like, helix-two turn-helix domain

IHF-like_H2TH

3

IPR055204

55,204

Heterogeneous nuclear ribonucleoprotein L, RRM domain

HNRNPL_RRM

Domain

10,142

false

This entry represents the fourth RRM domain found at the C-terminal of human Heterogeneous nuclear ribonucleoprotein L (HNRNPL) [ ], an splicing factor binding to exonic or intronic sites and acting as either an activator or repressor of exon inclusion [ , , , , ]. It is also found in the Polypyrimidine tract-binding p...

[]

0

[ "PFAM" ]

[ "PF22976" ]

[ "RRM_10" ]

[ 10142 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-6803529", "R-BTA-72163", "R-BTA-72203", "R-HSA-6803529", "R-HSA-72163", "R-HSA-72203", "R-MMU-6803529", "R-MMU-72163", "R-MMU-72203", "R-RNO-6803529", "R-RNO-72163", "R-RNO-72203" ]

[ "REACTOME:R-BTA-6803529", "REACTOME:R-BTA-72163", "REACTOME:R-BTA-72203", "REACTOME:R-HSA-6803529", "REACTOME:R-HSA-72163", "REACTOME:R-HSA-72203", "REACTOME:R-MMU-6803529", "REACTOME:R-MMU-72163", "REACTOME:R-MMU-72203", "REACTOME:R-RNO-6803529", "REACTOME:R-RNO-72163", "REACTOME:R-RNO-72203"...

12

[ "1qm9", "2adc", "2evz", "2mju", "2mqn", "2mqq", "3s01", "3to8", "3tyt", "4cq1", "4qpt" ]

11

[ "PUB00154214", "PUB00154909", "PUB00154910", "PUB00154911", "PUB00154912", "PUB00154913" ]

[ "26051023", "11809897", "22570490", "24164894", "25623890", "33174841" ]

[ "The Signature of the Five-Stranded vRRM Fold Defined by Functional, Structural and Computational Analysis of the hnRNP L Protein.", "Human AP-endonuclease 1 and hnRNP-L interact with a nCaRE-like repressor element in the AP-endonuclease 1 promoter.", "A conserved serine of heterogeneous nuclear ribonucleoprote...

[ 2015, 2002, 2012, 2014, 2015, 2020 ]

6

[]

[ "IPR034817" ]

0

1

0

[ "Eukaryota" ]

[ 10142 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 3, 24, 29, 31, 24, 32 ]

6

true

Domain

Heterogeneous nuclear ribonucleoprotein L, RRM domain

HNRNPL_RRM

2

IPR055205

55,205

5,10-methenyltetrahydromethanopterin hydrogenase, N-terminal domain

HMD_N

Domain

153

false

This entry represents the N-terminal domain of 5,10-methenyltetrahydromethanopterin hydrogenase (HMD) and related proteins, an enzyme of the methanogenic energy metabolism. HMD is an iron-sulphur-cluster-free enzyme that contains an intrinsic CO ligand bound to iron. This domain has a Rossmann fold-like structure that ...

[]

0

[ "PFAM" ]

[ "PF22616" ]

[ "HMD_N" ]

[ 153 ]

1

[ "EC", "METACYC" ]

[ "1.12.98.2", "PWY-7784" ]

[ "EC:1.12.98.2", "METACYC:PWY-7784" ]

2

[ "2b0j", "3daf", "3dag", "3f46", "3f47", "3h65", "4jjf", "4jjg", "4yt2", "4yt4", "4yt5", "4yt8", "4yte", "5ok4", "6ggu", "6hac", "6hae", "6hav", "6hux", "6huy", "6huz", "6yk9", "6yka", "6ykb" ]

24

[ "PUB00039471", "PUB00051317", "PUB00051862", "PUB00088210", "PUB00154008" ]

[ "16540118", "18653896", "19162018", "26094576", "23873755" ]

[ "The crystal structure of the apoenzyme of the iron-sulphur cluster-free hydrogenase.", "The crystal structure of [Fe]-hydrogenase reveals the geometry of the active site.", "The crystal structure of C176A mutated [Fe]-hydrogenase suggests an acyl-iron ligation in the active site iron complex.", "Towards a fu...

[ 2006, 2008, 2009, 2015, 2013 ]

5

[]

0

null

[ "Desulfurobacterium", "Methanobacteriota", "bioreactor metagenome" ]

[ 5, 147, 1 ]

3

[]

0

true

Domain

5,10-methenyltetrahydromethanopterin hydrogenase, N-terminal domain

HMD_N

8

IPR055206

55,206

ATP-dependent RNA helicase SUV3, DEXQ-box helicase domain

DEXQc_SUV3

Domain

9,970

false

This entry represents the DEXQ-box helicase domain found in ATP-dependent RNA helicase SUPV3L1 (Suv3) [ ] and similar sequences from eukaryotes and bacteria. SUV3 is a major helicase player in mitochondrial RNA metabolism. It is a component of the mitochondrial degradosome (mtEXO) complex, that degrades 3' overhang dou...

[]

0

[ "PFAM" ]

[ "PF22527" ]

[ "DEXQc_Suv3" ]

[ 9970 ]

1

[ "EC", "REACTOME" ]

[ "3.6.4.13", "R-HSA-9836573" ]

[ "EC:3.6.4.13", "REACTOME:R-HSA-9836573" ]

2

[ "3rc3", "3rc8", "6f4a", "7w1r" ]

4

[ "PUB00091432", "PUB00095346" ]

[ "22101826", "29967381" ]

[ "Human Suv3 protein reveals unique features among SF2 helicases.", "Dedicated surveillance mechanism controls G-quadruplex forming non-coding RNAs in human mitochondria." ]

[ 2011, 2018 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 4380, 5529, 61 ]

3

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 9, 1, 1, 1, 3, 2, 1, 2, 3, 1, 1, 30 ]

12

true

Domain

ATP-dependent RNA helicase SUV3, DEXQ-box helicase domain

DEXQc_SUV3

2

IPR055207

55,207

DNA-directed RNA polymerase III subunit RPC3, winged-helix domain

POLR3C_WHD

Domain

4,325

false

This entry represents the WH-like domain (WH4) found at the C-terminal of the DNA-directed RNA polymerase III subunit RPC3 (POLR3C) from humans (also known as hRPC62) [ ]. POLR3C exhibits helicase activity [ ]. Helicases are enzymes responsible for unwinding DNA or RNA helices, facilitating essential processes such as ...

[]

0

[ "PFAM" ]

[ "PF22536" ]

[ "WHD_POLR3C" ]

[ 4325 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-76061", "R-BTA-76066", "R-BTA-76071", "R-DDI-76061", "R-DDI-76066", "R-HSA-1834949", "R-HSA-73780", "R-HSA-73980", "R-HSA-749476", "R-HSA-76061", "R-HSA-76066", "R-HSA-76071", "R-MMU-76061", "R-MMU-76066", "R-MMU-76071", "R-RNO-76061", "R-RNO-76066", "R-RNO-76071", "R-SCE-...

[ "REACTOME:R-BTA-76061", "REACTOME:R-BTA-76066", "REACTOME:R-BTA-76071", "REACTOME:R-DDI-76061", "REACTOME:R-DDI-76066", "REACTOME:R-HSA-1834949", "REACTOME:R-HSA-73780", "REACTOME:R-HSA-73980", "REACTOME:R-HSA-749476", "REACTOME:R-HSA-76061", "REACTOME:R-HSA-76066", "REACTOME:R-HSA-76071", "...

21

[ "2xub", "2xv4", "5afq", "5fj8", "5fj9", "5fja", "6cnb", "6cnc", "6cnd", "6cnf", "6eu0", "6eu1", "6eu2", "6eu3", "6f40", "6f41", "6f42", "6f44", "6tut", "7a6h", "7ae1", "7ae3", "7aea", "7ast", "7d58", "7d59", "7dn3", "7du2", "7fji", "7fjj", "7z0h", "7z1l"...

57

[ "PUB00090049", "PUB00154177" ]

[ "21358628", "31529052" ]

[ "Structure-function analysis of hRPC62 provides insights into RNA polymerase III transcription initiation.", "The hRPC62 subunit of human RNA polymerase III displays helicase activity." ]

[ 2011, 2019 ]

2

[]

0

null

[ "Eukaryota" ]

[ 4325 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizo...

[ 7, 1, 6, 1, 5, 2, 1, 3, 1, 1, 6 ]

11

true

Domain

DNA-directed RNA polymerase III subunit RPC3, winged-helix domain

POLR3C_WHD

9

IPR055208

55,208

DNA polymerase II, insertion domain

PolB_insertion

Domain

3,406

false

This is the insertion domain found in DNA polymerase II from E. coli (PolB), a member of family B of DNA polymerases [ ]. Members of this family are found in proteobacteria.

[]

0

[ "PFAM" ]

[ "PF22587" ]

[ "DNApolII_insertion" ]

[ 3406 ]

1

[]

0

[ "1q8i", "3k57", "3k58", "3k59", "3k5l", "3k5m", "3k5n", "3k5o", "3maq" ]

9

[ "PUB00054786" ]

[ "20064374" ]

[ "Structural insight into translesion synthesis by DNA Pol II." ]

[ 2009 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "hydrothermal vent metagenome" ]

[ 3403, 2, 1 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Domain

DNA polymerase II, insertion domain

PolB_insertion

7

IPR055209

55,209

RsiG-like domain

RsiG-like_dom

Domain

1,396

false

This entry represents a domain found in the anti-sigma factor RsiG from Streptomyces and its homologues. RsiG binds and sequesters the sporulation-specific sigma factor WhiG in a fashion dependent on 3',5'-cyclic diguanylic acid (c-di-GMP). This domain adopts an α-helix and in Streptomyces self associates to form a dim...

[]

0

[ "PFAM" ]

[ "PF22802" ]

[ "RsiG" ]

[ 1396 ]

1

[]

0

[ "6pfj", "6pfv", "7lq2", "7lq3", "7lq4" ]

5

[ "PUB00145669", "PUB00154215" ]

[ "31810759", "34290147" ]

[ "c-di-GMP Arms an Anti-σ to Control Progression of Multicellular Differentiation in Streptomyces.", "Evolution of a σ-(c-di-GMP)-anti-σ switch." ]

[ 2020, 2021 ]

2

[]

0

null

[ "Actinomycetota", "ecological metagenomes" ]

[ 1350, 46 ]

2

[]

0

true

Domain

RsiG-like domain

RsiG-like_dom

5

IPR055210

55,210

Activating protease CtpA/B, N-terminal domain

CtpA/B_N

Domain

14,378

false

This domain is found N-terminal of Carboxy-terminal processing protease CtpA, CtpB and related proteins. CtpB is involved in signal transduction pathway leading to the proteolytic activation of the mother cell transcription factor pro-sigma-K during sporulation. This domain contains auto-cleavage site at which it is pr...

[]

0

[ "PFAM" ]

[ "PF22694" ]

[ "CtpB_N-like" ]

[ 14378 ]

1

[ "EC", "METACYC" ]

[ "3.4.21.-", "PWY-7884" ]

[ "EC:3.4.21.-", "METACYC:PWY-7884" ]

2

[ "4c2c", "4c2d", "4c2e", "4c2f", "4c2g", "4c2h", "7rpq", "7rqh", "8sxe", "8sxf", "8sxg", "8sxh" ]

12

[ "PUB00153563" ]

[ "24243021" ]

[ "CtpB assembles a gated protease tunnel regulating cell-cell signaling during spore formation in Bacillus subtilis." ]

[ 2013 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 14118, 24, 236 ]

3

[]

0

true

Domain

Activating protease CtpA/B, N-terminal domain

CtpA/B_N

5

IPR055212

55,212

PNO1, first type I KH domain

KH-I_PNO1_first

Domain

4,316

false

PNO1 is an RNA-binding protein that acts as a ribosome assembly factor and plays an important role in ribosome biogenesis. It positively regulates dimethylation of two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 18S rRNA. PNO1 contains two K-homology (KH) RNA-binding domains, the first one...

[]

0

[ "CDD" ]

[ "cd22391" ]

[ "KH-I_PNO1_rpt1" ]

[ 4316 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-6791226", "R-HSA-6790901", "R-HSA-6791226", "R-MMU-6791226", "R-RNO-6791226" ]

[ "REACTOME:R-BTA-6791226", "REACTOME:R-HSA-6790901", "REACTOME:R-HSA-6791226", "REACTOME:R-MMU-6791226", "REACTOME:R-RNO-6791226" ]

5

[ "5oql", "5wlc", "5wyj", "5wyk", "6eml", "6fai", "6g18", "6g4s", "6g4w", "6g51", "6g53", "6g5i", "6ke6", "6lqp", "6lqq", "6lqr", "6lqs", "6lqt", "6lqu", "6rbd", "6rxt", "6rxu", "6rxv", "6rxx", "6rxy", "6rxz", "6y7c", "6zqa", "6zqb", "6zqc", "6zqd", "6zqe"...

84

[ "PUB00086871", "PUB00101822", "PUB00150591", "PUB00150592", "PUB00150593", "PUB00150594", "PUB00150595" ]

[ "25851604", "29875412", "29155690", "15497447", "31800162", "32483111", "30862720" ]

[ "The human 18S rRNA base methyltransferases DIMT1L and WBSCR22-TRMT112 but not rRNA modification are required for ribosome biogenesis.", "Visualizing late states of human 40S ribosomal subunit maturation.", "Cryo-EM structure of a late pre-40S ribosomal subunit from Saccharomyces cerevisiae.", "Cloning and ch...

[ 2015, 2018, 2017, 2004, 2020, 2020, 2019 ]

7

[]

0

null

[ "Eukaryota" ]

[ 4316 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 2, 1, 2, 1, 2, 1, 1, 6, 9, 1, 1, 5 ]

12

true

Domain

PNO1, first type I KH domain

KH-I_PNO1_first

1

IPR055213

55,213

IML1/DEPDC5, N-terminal double psi beta-barrel domain

IML1_double_psi_beta_barrel

Domain

3,292

false

This entry represents the N-terminal double psi β-barrel domain found in IML1/DEPDC5 proteins predominantly from animals. The IML1 protein family is involved in the regulation of the mTORC1 signaling pathway, particularly in response to amino acid availability. Members of this family are components of the GATOR1 comple...

[]

0

[ "PFAM" ]

[ "PF23013" ]

[ "IML1_N" ]

[ 3292 ]

1

[ "REACTOME", "REACTOME", "REACTOME" ]

[ "R-DDI-9639288", "R-HSA-9639288", "R-MMU-9639288" ]

[ "REACTOME:R-DDI-9639288", "REACTOME:R-HSA-9639288", "REACTOME:R-MMU-9639288" ]

3

[ "6ces", "6cet", "7t3a", "7t3b", "7t3c", "8fw5", "9v0j" ]

7

[ "PUB00099065" ]

[ "29590090" ]

[ "Architecture of the human GATOR1 and GATOR1-Rag GTPases complexes." ]

[ 2018 ]

1

[]

0

null

[ "Eukaryota" ]

[ 3292 ]

1

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 16, 4, 24, 10, 4 ]

5

true

Domain

IML1/DEPDC5, N-terminal double psi beta-barrel domain

IML1_double_psi_beta_barrel

3

IPR055214

55,214

DSP-PTPase phosphatase fused to NAD+ Kinase

PTP-NADK

Domain

2,698

false

This domain is found in NAD kinase 2 from Arabidopsis thaliana, related sequences from plants and uncharacterised sequences from bacteria. While the land plant version of this DSP-PTPase domain is likely inactive as the catalytic cysteine is replaced by serine or threonine, the rest are predicted to be active. Keeping ...

[]

0

[ "PFAM" ]

[ "PF22741" ]

[ "PTP-NADK" ]

[ 2698 ]

1

[]

0

[]

0

[ "PUB00153826", "PUB00154187" ]

[ "36968430", "24968225" ]

[ "New biochemistry in the Rhodanese-phosphatase superfamily: emerging roles in diverse metabolic processes, nucleic acid modifications, and biological conflicts.", "Genome-wide analysis of the NADK gene family in plants." ]

[ 2023, 2014 ]

2

[]

0

null

[ "Bacteria", "Barrevirus sp.", "Eukaryota", "unclassified sequences" ]

[ 1752, 1, 917, 28 ]

4

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 4, 7, 20 ]

3

true

Domain

DSP-PTPase phosphatase fused to NAD+ Kinase

PTP-NADK

8

IPR055215

55,215

Sperm-associated microtubule inner protein 5 domain

SPMIP5_dom

Domain

478

false

This entry represents a domain found in Sperm-associated microtubule inner protein 5 (SPMIP5 also known as C10orf82) and its homologues. SPMIP5 is a mammalian sperm-specific microtubule inner protein that probably plays a role in the stabilisation of the axonemal microtubules [ ]. This domain binds to tubulin.

[]

0

[ "PFAM" ]

[ "PF22573" ]

[ "SPMIP5" ]

[ 478 ]

1

[]

0

[ "8iyj", "8otz", "9fqr" ]

3

[ "PUB00151496" ]

[ "37327785" ]

[ "Structural specializations of the sperm tail." ]

[ 2023 ]

1

[]

0

null

[ "Eumetazoa" ]

[ 478 ]

1

[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 2, 5 ]

3

true

Domain

Sperm-associated microtubule inner protein 5 domain

SPMIP5_dom

6

IPR055216

55,216

Ant venom allergen Sol i 2/4

Sol_i_2/4

Domain

66

false

Sol i 2, one of four known potent allergens from the venom of red imported fire ant, is a powerful trigger of anaphylaxis. It causes production of IgE antibody in many individuals stung by fire ants. The closest structure homologue of Sol I 2 is the odorant binding protein and pheromone binding protein LUSH of the frui...

[]

0

[ "PFAM" ]

[ "PF22750" ]

[ "Sol_i_2" ]

[ 66 ]

1

[]

0

[ "2ygu" ]

1

[ "PUB00057651" ]

[ "22100449" ]

[ "Crystal structure of sol I 2: a major allergen from fire ant venom." ]

[ 2012 ]

1

[]

0

null

[ "Formicidae" ]

[ 66 ]

1

[]

0

true

Domain

Ant venom allergen Sol i 2/4

Sol_i_2/4

7

IPR055217

55,217

EMC2, TPR-like domain

TPR_EMC2

Domain

4,486

false

This entry represents a TPR-like domain from the central region of EMC2 and its homolgoues. ER membrane protein complex subunit 2 (EMC2, also known as tetratricopeptide repeat protein 35) is a tetratricopeptide repeat-containing protein, and a component of the ER membrane protein complex (EMC), which is required for ef...

[]

0

[ "PFAM" ]

[ "PF22890" ]

[ "TPR_EMC2" ]

[ 4486 ]

1

[]

0

[ "6ww7", "6y4l", "6z3w", "7ado", "7adp", "8eoi", "8j0n", "8j0o", "8s9s", "9c7v" ]

10

[ "PUB00096681", "PUB00096682" ]

[ "32459176", "32439656" ]

[ "The architecture of EMC reveals a path for membrane protein insertion.", "Structural basis for membrane insertion by the human ER membrane protein complex." ]

[ 2020, 2020 ]

2

[]

0

null

[ "Bacteria", "Eukaryota" ]

[ 29, 4457 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Schizosaccharomyces pombe (stra...

[ 10, 1, 1, 4, 4, 2, 1, 4, 4, 1, 11 ]

11

true

Domain

EMC2, TPR-like domain

TPR_EMC2

8

IPR055219

55,219

Septum site-determining protein MinC, N-terminal domain

MinC_N_1

Domain

2,575

false

This entry represents the N-terminal domain of Septum site-determining protein MinC and related proteins mainly found in firmicutes. MinC is a cell division inhibitor that blocks the formation of polar Z ring septums. It consists of two domains. The N-terminal domain interacts with FtsZ and inhibits FtsZ polymerisation...

[]

0

[ "PFAM" ]

[ "PF22642" ]

[ "MinC_N_1" ]

[ 2575 ]

1

[]

0

[ "2m4i" ]

1

[ "PUB00154916" ]

[ "23853099" ]

[ "MinC protein shortens FtsZ protofilaments by preferentially interacting with GDP-bound subunits." ]

[ 2013 ]

1

[]

0

null

[ "Bacteria", "Geodia barretti", "metagenomes" ]

[ 2565, 2, 8 ]

3

[]

0

true

Domain

Septum site-determining protein MinC, N-terminal domain

MinC_N_1

8

IPR055220

55,220

Spartan-like, zinc binding domain

SPRTN_ZBD

Domain

2,336

false

This zinc binding domain (ZBD) is found in DNA-dependent metalloprotease Spartan (SPRTN) and its homologues. SPRTN cleaves DNA-protein crosslinks (DPCs) and protects cells from DPC-induced genome instability. The zinc binding domain is located in close proximity to the catalytic domain and contributes to the ssDNA spec...

[]

0

[ "PFAM" ]

[ "PF22934" ]

[ "SPRTN_ZBD" ]

[ 2336 ]

1

[ "EC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "3.4.24.-", "PWY-8119", "R-BTA-110320", "R-CEL-110320", "R-DRE-110320", "R-HSA-110320", "R-MMU-110320", "R-RNO-110320", "R-XTR-110320" ]

[ "EC:3.4.24.-", "METACYC:PWY-8119", "REACTOME:R-BTA-110320", "REACTOME:R-CEL-110320", "REACTOME:R-DRE-110320", "REACTOME:R-HSA-110320", "REACTOME:R-MMU-110320", "REACTOME:R-RNO-110320", "REACTOME:R-XTR-110320" ]

9

[ "6mdw", "6mdx" ]

2

[ "PUB00095542" ]

[ "30893605" ]

[ "Structural Insight into DNA-Dependent Activation of Human Metalloprotease Spartan." ]

[ 2019 ]

1

[]

0

null

[ "Eukaryota" ]

[ 2336 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 2, 2, 2, 1, 3 ]

6

true

Domain

Spartan-like, zinc binding domain

SPRTN_ZBD

1

IPR055221

55,221

DNA replication complex GINS protein PSF3, N-terminal domain

PSF3_N

Domain

3,434

false

This entry represents the GINS/PriA/YqbF domain, which is found in the N-terminal region of the GINS complex protein PSF3 [ ]. The GINS complex is crucial for the establishment of DNA replication forks and replisome progression in eukaryotes. The crystal structure of the human GINS complex reveals a heterotetrameric as...

[]

0

[ "PFAM" ]

[ "PF22466" ]

[ "PSF3_N" ]

[ 3434 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-176974", "R-DDI-176974", "R-HSA-176974", "R-MMU-176974", "R-SCE-176974", "R-SPO-176974" ]

[ "REACTOME:R-BTA-176974", "REACTOME:R-DDI-176974", "REACTOME:R-HSA-176974", "REACTOME:R-MMU-176974", "REACTOME:R-SCE-176974", "REACTOME:R-SPO-176974" ]

6

[ "2e9x", "2eho", "2q9q", "3jc5", "3jc6", "3jc7", "5u8s", "5u8t", "6hv9", "6ptj", "6ptn", "6pto", "6raw", "6rax", "6ray", "6raz", "6skl", "6u0m", "6xtx", "6xty", "7pfo", "7plo", "7pmk", "7pmn", "7qhs", "7z13", "8b9a", "8b9b", "8b9c", "8b9d", "8kg6", "8kg8"...

45

[ "PUB00015004", "PUB00040384", "PUB00040400", "PUB00044029", "PUB00151701", "PUB00151996", "PUB00152060", "PUB00154055", "PUB00154917", "PUB00154918" ]

[ "12730134", "17417653", "17545466", "17652513", "28096349", "35585232", "26854665", "32453425", "34694004", "34700328" ]

[ "GINS, a novel multiprotein complex required for chromosomal DNA replication in budding yeast.", "Structure of the human GINS complex and its assembly and functional interface in replication initiation.", "Crystal structure of the human GINS complex.", "Crystal structure of the GINS complex and functional ins...

[ 2003, 2007, 2007, 2007, 2017, 2022, 2016, 2020, 2021, 2021 ]

10

[]

0

null

[ "Eukaryota" ]

[ 3434 ]

1

[ "Arabidopsis thaliana", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "...

[ 4, 1, 3, 3, 2, 1, 5, 3, 1, 1, 9 ]

11

true

Domain

DNA replication complex GINS protein PSF3, N-terminal domain

PSF3_N

6

IPR055222

55,222

PRISE-like, Rossmann-fold domain

PRISE-like_Rossmann-fold

Domain

9,221

false

This NAD(P)-binding Rossmann-fold-like domain is found in a number of enzymes with oxidoreductase activity from eukaryotes and uncharacterised bacterial sequences [ , , ]. Amongst them are the PRISEs (Progesterone 5beta-reductase and/or iridoid synthase-like 1,4-enone reductases) that are involved in cardenolide and ir...

[]

0

[ "PFAM", "CDD" ]

[ "PF22917", "cd08948" ]

[ "PRISE", "5beta-POR_like_SDR_a" ]

[ 8948, 8088 ]

2

[]

0

[ "2v6f", "2v6g", "5coa", "5cob", "5dbf", "5dbg", "5dbi", "5dcu", "5dcw", "5dcy", "5df1", "5emh", "5mlh", "5mlm", "5mlr", "6el3", "6gsd" ]

17

[ "PUB00025631", "PUB00049597", "PUB00081093", "PUB00081096", "PUB00154919", "PUB00154920" ]

[ "8262916", "18032383", "19011750", "19027726", "28233494", "29076725" ]

[ "The crystallographic structure of a human dihydropteridine reductase NADH binary complex expressed in Escherichia coli by a cDNA constructed from its rat homologue.", "The crystal structure of progesterone 5beta-reductase from Digitalis lanata defines a novel class of short chain dehydrogenases/reductases.", "...

[ 1993, 2008, 2008, 2009, 2017, 2017 ]

6

[]

0

null

[ "Bacteria", "Eukaryota", "ecological metagenomes" ]

[ 3059, 6128, 34 ]

3

[ "Arabidopsis thaliana", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)", "Zea mays" ]

[ 8, 2, 10, 1, 7 ]

5

true

Domain

PRISE-like, Rossmann-fold domain

PRISE-like_Rossmann-fold

5

IPR055223

55,223

Fe(3+) ions import ATP-binding protein FbpC, regulatory domain

FbpC_RD

Domain

78

false

This entry represents the regulatory domain (RD) of Fe(3+) ions import ATP-binding protein FbpC, the nucleotide-binding domain of the iron-uptake ABC transporter FbpABC from Neisseria gonorrhoeae. This domain adopts two OB-folds per monomer [ ]. Members of this group are mainly found in Neisseria species.

[]

0

[ "PFAM" ]

[ "PF22443" ]

[ "FbpC-like_RD" ]

[ 78 ]

1

[ "EC" ]

[ "7.2.2.7" ]

[ "EC:7.2.2.7" ]

1

[ "3fvq" ]

1

[ "PUB00091492" ]

[ "19748342" ]

[ "Insights into how nucleotide-binding domains power ABC transport." ]

[ 2009 ]

1

[]

0

null

[ "Bacteria" ]

[ 78 ]

1

[]

0

true

Domain

Fe(3+) ions import ATP-binding protein FbpC, regulatory domain

FbpC_RD

7

IPR055224

55,224

MLPTv-like, winged helix-turn-helix domain

MLPTv-like_wHTH

Domain

4

false

This entry represents a winged helix-turn-helix (wHTH) domain present in MLPTv (MarR-like protein from Thermoplasma volcanium) [ ].

[]

0

[ "PFAM" ]

[ "PF22393" ]

[ "MLPTv-like_HTH" ]

[ 4 ]

1

[]

0

[ "3lfk" ]

1

[ "PUB00154071" ]

[ "20162616" ]

[ "A reported archaeal mechanosensitive channel is a structural homolog of MarR-like transcriptional regulators." ]

[ 2010 ]

1

[]

0

null

[ "Methanobacteriati" ]

[ 4 ]

1

[]

0

true

Domain

MLPTv-like, winged helix-turn-helix domain

MLPTv-like_wHTH

9

IPR055226

55,226

FilE, C-terminal domain

FilE_C

Domain

223

false

This entry represents a domain found C-terminal in FilE protein. FilE is found almost exclusively in Acinetobacter, and is assigned as a putative pilus system protein from local genomic contexts that include several additional putative pilus system proteins. It is predicted to adopt a globular structure similar to gala...

[]

0

[ "PFAM" ]

[ "PF22881" ]

[ "FilE_C" ]

[ 223 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Moraxellaceae" ]

[ 223 ]

1

[]

0

true

Domain

FilE, C-terminal domain

FilE_C

1

IPR055227

55,227

ATP-dependent helicase HRQ1, winged helix domain

HRQ1_WHD

Domain

8,148

false

This domain is found in ATP-dependent helicase HRQ1 from yeast and its homologues. HRQ1 is a helicase with 3'-5' helicase activity involved in genome stability [ ]. Hrq1 is able to unwind relatively long duplex DNA up to 120-bp and is significantly stimulated by a preexisting fork structure. This domain is predicted to...

[]

0

[ "PFAM" ]

[ "PF22982" ]

[ "WHD_HRQ1" ]

[ 8148 ]

1

[]

0

[ "6znp", "6znq", "6zns" ]

3

[ "PUB00154018" ]

[ "23456718" ]

[ "Hrq1 functions independently of Sgs1 to preserve genome integrity in Saccharomyces cerevisiae." ]

[ 2013 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 288, 5293, 2460, 107 ]

4

[ "Arabidopsis thaliana", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)", "Zea mays" ]

[ 7, 1, 3, 1, 1, 12 ]

6

true

Domain

ATP-dependent helicase HRQ1, winged helix domain

HRQ1_WHD

4

IPR055228

55,228

Cas9, RuvC domain

Cas9_RuvC

Domain

845

false

This entry represent a RuvC endonuclease domain found in CRISPR-Cas9 from Streptococcus pyogenes and related sequences, mainly from firmicutes [ , , , ]. This domain, and the HNH ( ) domain of Cas9, are used to cleave the DNA strands complementary (target) and non-complementary (non-target) to the crRNA, respectively [...

[]

0

[ "PFAM" ]

[ "PF22702" ]

[ "Cas9_RuvC" ]

[ 845 ]

1

[]

0

[ "4cmp", "4cmq", "4oo8", "4un3", "4un4", "4un5", "4zt0", "4zt9", "5axw", "5b2r", "5b2s", "5b2t", "5czz", "5f9r", "5fq5", "5fw1", "5fw2", "5fw3", "5vw1", "5vzl", "5xbl", "5y36", "6aeb", "6aeg", "6ai6", "6ifo", "6k3z", "6k4p", "6k4q", "6k4s", "6k4u", "6k57"...

142

[ "PUB00076235", "PUB00077735", "PUB00153851", "PUB00153852", "PUB00153853" ]

[ "24529477", "24505130", "26990991", "25079318", "26113724" ]

[ "Crystal structure of Cas9 in complex with guide RNA and target DNA.", "Structures of Cas9 endonucleases reveal RNA-mediated conformational activation.", "Structural Basis for the Altered PAM Specificities of Engineered CRISPR-Cas9.", "Structural basis of PAM-dependent target DNA recognition by the Cas9 endon...

[ 2014, 2014, 2016, 2014, 2015 ]

5

[]

0

null

[ "Bacteria", "Chlamydomonas reinhardtii", "Methanimicrococcus", "metagenomes" ]

[ 840, 1, 2, 2 ]

4

[]

0

true

Domain

Cas9, RuvC domain

Cas9_RuvC

5

IPR055229

55,229

VEGFR1-3, fifth immunoglobulin-like domain

VEGFR1-3_5th

Domain

5,062

false

This is the fifth immunoglobulin-like domain of human Vascular endothelial growth factor receptor 1, 2 and 3 (VEGFR1-3) and similar sequences mainly found in animals. VEGFR-1 is a cell-surface receptor for VEGFA, VEGFB and PGF. It is a tyrosine-protein kinase that plays an essential role in the development of embryonic...

[]

0

[ "PFAM" ]

[ "PF22971" ]

[ "Ig_VEGFR-1-like_5th" ]

[ 5062 ]

1

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "2.7.10.1", "R-DRE-194306", "R-DRE-195399", "R-DRE-4420097", "R-DRE-5218921", "R-HSA-194306", "R-HSA-195399", "R-HSA-216083", "R-HSA-4420097", "R-HSA-5218921", "R-HSA-9013695", "R-HSA-9673768", "R-HSA-9856530", "R-MMU-194306", "R-MMU-195399", "R-MMU-4420097", "R-MMU-5218921", "R-RN...

[ "EC:2.7.10.1", "REACTOME:R-DRE-194306", "REACTOME:R-DRE-195399", "REACTOME:R-DRE-4420097", "REACTOME:R-DRE-5218921", "REACTOME:R-HSA-194306", "REACTOME:R-HSA-195399", "REACTOME:R-HSA-216083", "REACTOME:R-HSA-4420097", "REACTOME:R-HSA-5218921", "REACTOME:R-HSA-9013695", "REACTOME:R-HSA-9673768"...

21

[ "3v2a", "3v6b", "4bsj", "5oyj", "5t89" ]

5

[ "PUB00000215", "PUB00055146", "PUB00065576", "PUB00140409", "PUB00154321", "PUB00154322", "PUB00154922", "PUB00154923", "PUB00154924", "PUB00154925" ]

[ "1417831", "21454754", "21402080", "25385546", "22207738", "23878260", "19779139", "20080685", "20445537", "21273538" ]

[ "Identification of the KDR tyrosine kinase as a receptor for vascular endothelial cell growth factor.", "Proteoglycan-Specific Molecular Switch for RPTP{sigma} Clustering and Neuronal Extension.", "The immunoglobulin-like domains 1 and 2 of the protein tyrosine phosphatase LAR adopt an unusual horseshoe-like co...

[ 1992, 2011, 2011, 2014, 2012, 2013, 2009, 2010, 2010, 2011 ]

10

[ "IPR003599" ]

[]

1

0

1

[ "Eumetazoa" ]

[ 5062 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 16, 8, 9, 17 ]

4

true

Domain

VEGFR1-3, fifth immunoglobulin-like domain

VEGFR1-3_5th

5

IPR055230

55,230

Tiam1/2, second PH-like domain

PH_Tiam1/2

Domain

4,420

false

This entry represents the second PH domain found in TIAM1/2 proteins from human and its orthologues from Drosophila, SIF1/2. The TIAM family proteins are guanine nucleotide exchange factors (GEFs) that modulate the activity of RHO-like GTPases, linking extracellular signals to cytoskeletal dynamics. They are involved i...

[]

0

[ "PFAM" ]

[ "PF23014" ]

[ "PH_Tiam1" ]

[ 4420 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-DME-193648", "R-DME-3928662", "R-DME-3928665", "R-DME-416482", "R-DME-8980692", "R-DME-9013148", "R-DME-9013149", "R-DME-9013404", "R-DME-9013423", "R-HSA-193648", "R-HSA-1989781", "R-HSA-3928662", "R-HSA-3928665", "R-HSA-416482", "R-HSA-8980692", "R-HSA-9013148", "R-HSA-9013149",...

[ "REACTOME:R-DME-193648", "REACTOME:R-DME-3928662", "REACTOME:R-DME-3928665", "REACTOME:R-DME-416482", "REACTOME:R-DME-8980692", "REACTOME:R-DME-9013148", "REACTOME:R-DME-9013149", "REACTOME:R-DME-9013404", "REACTOME:R-DME-9013423", "REACTOME:R-HSA-193648", "REACTOME:R-HSA-1989781", "REACTOME:R...

29

[ "1foe" ]

1

[ "PUB00021597" ]

[ "11130063" ]

[ "Crystal structure of Rac1 in complex with the guanine nucleotide exchange region of Tiam1." ]

[ 2000 ]

1

[ "IPR001849" ]

[]

1

0

1

[ "Metazoa" ]

[ 4420 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 23, 12, 13, 11, 6 ]

6

true

Domain

Tiam1/2, second PH-like domain

PH_Tiam1/2

6

IPR055231

55,231

PIK3R4-like, middle domain

PIK3R4-like_middle

Domain

10,258

false

This entry represents a TPR-like domain found in diverse eukaryotic kinases and phosphatases. The domain is present in phosphoinositide 3-kinase regulatory subunit 4 (PIK3R4), serine/threonine-protein kinase VPS15, protein phosphatase 2A regulatory subunits, and protein phosphatase 4 regulatory subunit 1. The domain sh...

[]

0

[ "PFAM" ]

[ "PF22956" ]

[ "2AA_helical" ]

[ 10258 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-DDI-113501", "R-DDI-1632852", "R-DDI-1660514", "R-DDI-1660516", "R-DDI-1660517", "R-DDI-198753", "R-DDI-202670", "R-DDI-389513", "R-DDI-5668599", "R-DDI-6811558", "R-DDI-69231", "R-DDI-69273", "R-HSA-109704", "R-HSA-113501", "R-HSA-1295596", "R-HSA-141444", "R-HSA-1632852", "R-H...

[ "REACTOME:R-DDI-113501", "REACTOME:R-DDI-1632852", "REACTOME:R-DDI-1660514", "REACTOME:R-DDI-1660516", "REACTOME:R-DDI-1660517", "REACTOME:R-DDI-198753", "REACTOME:R-DDI-202670", "REACTOME:R-DDI-389513", "REACTOME:R-DDI-5668599", "REACTOME:R-DDI-6811558", "REACTOME:R-DDI-69231", "REACTOME:R-DD...

196

[ "1b3u", "2iae", "2ie3", "2ie4", "2npp", "2nyl", "2nym", "2pf4", "2pkg", "3dw8", "3fga", "3k7v", "3k7w", "4i5l", "4i5n", "5dfz", "5kc2", "5w0w", "6ef4", "6iur", "6nts", "7bl1", "7cun", "7k36", "7pks", "7soy", "7ycx", "8rbx", "8rbz", "8rc4", "8so0", "8sor"...

52

[ "PUB00044322", "PUB00077159", "PUB00091364", "PUB00154327", "PUB00154926", "PUB00161600", "PUB00162463" ]

[ "11859360", "20643123", "26450213", "27630019", "23878393", "9078365", "22361507" ]

[ "The genome sequence of Schizosaccharomyces pombe.", "A phosphatidylinositol 3-kinase class III sub-complex containing VPS15, VPS34, Beclin 1, UVRAG and BIF-1 regulates cytokinesis and degradative endocytic traffic.", "Structure and flexibility of the endosomal Vps34 complex reveals the basis of its function on...

[ 2002, 2010, 2015, 2016, 2013, 1996, 2012 ]

7

[]

0

null

[ "Eukaryota", "Legionella maceachernii" ]

[ 10257, 1 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 9, 3, 7, 9, 19, 18, 3, 2, 18, 2, 2, 53 ]

12

true

Domain

PIK3R4-like, middle domain

PIK3R4-like_middle

1

IPR055232

55,232

DIS3-like exonuclease 2, C-terminal

Dis32-like_C

Domain

4

false

This domain is found at the C-terminal of DIS3-like exonuclease 2 from Schizosaccharomyces pombe (Dis32) and related proteins from Schizosaccharomyces. Dis32, also known as Dis3l2, is a 3'-5'-exoribonuclease that specifically recognises RNAs polyuridylated at their 3' end and mediates their degradation. This domain sho...

[]

0

[ "PFAM" ]

[ "PF22428" ]

[ "Dis32-like_C" ]

[ 4 ]

1

[]

0

[ "4ro1", "9cy7" ]

2

[ "PUB00153907" ]

[ "26057668" ]

[ "Structural analysis of Dis3l2, an exosome-independent exonuclease from Schizosaccharomyces pombe." ]

[ 2015 ]

1

[]

0

null

[ "Schizosaccharomyces" ]

[ 4 ]

1

[ "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1 ]

1

true

Domain

DIS3-like exonuclease 2, C-terminal

Dis32-like_C

4

IPR055233

55,233

PaaX-like, ferredoxin-like domain

PaaX-like_ferredoxin-like

Domain

3

false

This entry represents a ferredoxin-like domain in PaaX-like protein from Jannaschia sp. ( ). PaaX-like is a putative transcriptional regulator. Members of this group are specific to Rhodobacterales.

[]

0

[ "PFAM" ]

[ "PF22444" ]

[ "PaaX-like_Fer-like" ]

[ 3 ]

1

[]

0

[ "3l09" ]

1

[]

0

[]

0

null

[ "Rhodobacterales" ]

[ 3 ]

1

[]

0

true

Domain

PaaX-like, ferredoxin-like domain

PaaX-like_ferredoxin-like

2

IPR055234

55,234

Pheromone cCF10 receptor-like, TPR region

PrgX-like_TPR

Domain

13

false

This entry represents the C-terminal tetratricopeptide repeat region (TPR) of the pheromone cCF10 receptor from Enterococcus faecalis (PrgX, ), which serves as a molecular switch controlling expression of conjugation and virulence genes encoded by the conjugative plasmid pCF10. This region includes two domains: a large...

[]

0

[ "PFAM" ]

[ "PF22459" ]

[ "PrgX_C_TPR" ]

[ 13 ]

1

[]

0

[ "2aw6", "2awi", "2axu", "2axv", "2axz", "2grl", "2grm" ]

7

[ "PUB00039428", "PUB00099792" ]

[ "16339309", "17038121" ]

[ "Structure of peptide sex pheromone receptor PrgX and PrgX/pheromone complexes and regulation of conjugation in Enterococcus faecalis.", "Molecular basis for control of conjugation by bacterial pheromone and inhibitor peptides." ]

[ 2005, 2006 ]

2

[]

0

null

[ "Enterococcus", "Plasmid pHKK701" ]

[ 12, 1 ]

2

[]

0

true

Domain

Pheromone cCF10 receptor-like, TPR region

PrgX-like_TPR

8

IPR055235

55,235

Alpha-L-arabinofuranosidase 1, catalytic domain

ASD1_cat

Domain

17,628

false

This entry represents the catalytic domain of Alpha-L-arabinofuranosidase 1/2 from Arabidopsis thaliana (ASD1/2), Alpha-L-arabinofuranosidases from fungi (AbfA), Intracellular exo-alpha-(1->5)-L-arabinofuranosidase 1 and Exo-alpha-(1->6)-L-arabinofuranosidase from bacteria and similar uncharacterised sequences. ASD1 ma...

[]

0

[ "PFAM" ]

[ "PF22848" ]

[ "ASD1_dom" ]

[ 17628 ]

1

[ "EC" ]

[ "3.2.1.55" ]

[ "EC:3.2.1.55" ]

1

[ "1pz2", "1pz3", "1qw8", "1qw9", "2c7f", "2c8n", "2vrk", "2vrq", "2y2w", "3s2c", "3ug3", "3ug4", "3ug5", "4atw", "5o7z", "5o80", "5o81", "5o82", "6d25", "6sxu", "6sxv", "6zps", "6zpv", "6zpw", "6zpx", "6zpy", "6zpz", "6zq0", "6zq1", "6zt6", "6zt7", "6zt8"...

35

[ "PUB00055639", "PUB00058391", "PUB00063990", "PUB00153827", "PUB00153828", "PUB00154927", "PUB00161583" ]

[ "18563919", "22313787", "23221536", "21796714", "33524585", "18344421", "16233515" ]

[ "The structure of the complex between a branched pentasaccharide and Thermobacillus xylanilyticus GH-51 arabinofuranosidase reveals xylan-binding determinants and induced fit.", "Crystal structures of glycoside hydrolase family 51 α-L-arabinofuranosidase from Thermotoga maritima.", "Structural analysis of alpha...

[ 2008, 2012, 2012, 2011, 2021, 2008, 2003 ]

7

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "metagenomes" ]

[ 132, 12305, 5085, 2, 104 ]

5

[ "Arabidopsis thaliana", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 10, 1, 27, 62 ]

4

true

Domain

Alpha-L-arabinofuranosidase 1, catalytic domain

ASD1_cat

6

IPR055237

55,237

Cdc6, AAA+ ATPase-type lid domain

Cdc6_lid

Domain

4,664

false

This domain is found in ORC1-type DNA replication protein (also known as Cdc6) and related proteins found mainly in archaea. Cdc6 is a key protein involved in the pre-replication complex assembly. It contains AAA+ ATPase domain that is capped by a lid domain, represented by this entry [ , ].

[]

0

[ "PFAM" ]

[ "PF22703" ]

[ "Cdc6_lid" ]

[ 4664 ]

1

[]

0

[ "1fnn", "2qby", "2v1u" ]

3

[ "PUB00013199", "PUB00032187", "PUB00039942", "PUB00048937", "PUB00049536" ]

[ "11030343", "15465044", "17060327", "17761879", "17761880" ]

[ "Structure and function of Cdc6/Cdc18: implications for origin recognition and checkpoint control.", "Conformational changes induced by nucleotide binding in Cdc6/ORC from Aeropyrum pernix.", "Crystal structure of the human AAA+ protein RuvBL1.", "Replication origin recognition and deformation by a heterodime...

[ 2000, 2004, 2006, 2007, 2007 ]

5

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 4520, 9, 41, 3, 91 ]

5

[]

0

true

Domain

Cdc6, AAA+ ATPase-type lid domain

Cdc6_lid

3

IPR055238

55,238

VEGFR1-3-like, N-terminal Ig-like domain

VEGFR1-3_N_Ig-like

Domain

8,579

false

This entry represents the N-terminal Ig-like domain of Vascular endothelial growth factor receptor 1-3 (VEGFR1-3) from vertebrates [ , ]. Members are tyrosine kinase receptors with seven Ig-like domains in its extracellular portion. This entry also includes Platelet-derived growth factor receptor alpha, a tyrosine-prot...

[]

0

[ "PFAM" ]

[ "PF22854" ]

[ "VEGFR1-3_N_Ig-like" ]

[ 8579 ]

1

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", ...

[ "2.7.10.1", "R-DRE-1257604", "R-DRE-1433557", "R-DRE-1433559", "R-DRE-186763", "R-DRE-186797", "R-DRE-194306", "R-DRE-195399", "R-DRE-4420097", "R-DRE-5218921", "R-DRE-5673001", "R-DRE-6811558", "R-DRE-9856649", "R-HSA-1257604", "R-HSA-186763", "R-HSA-186797", "R-HSA-194306", "R-HS...

[ "EC:2.7.10.1", "REACTOME:R-DRE-1257604", "REACTOME:R-DRE-1433557", "REACTOME:R-DRE-1433559", "REACTOME:R-DRE-186763", "REACTOME:R-DRE-186797", "REACTOME:R-DRE-194306", "REACTOME:R-DRE-195399", "REACTOME:R-DRE-4420097", "REACTOME:R-DRE-5218921", "REACTOME:R-DRE-5673001", "REACTOME:R-DRE-6811558...

52

[ "3mjg", "3v2a", "4bsk", "5t89", "7lbf", "7ram" ]

6

[ "PUB00022638", "PUB00154321", "PUB00154322", "PUB00154323", "PUB00154324", "PUB00162460" ]

[ "14684734", "22207738", "23878260", "28111021", "33626330", "10947961" ]

[ "The crystal structure of placental growth factor in complex with domain 2 of vascular endothelial growth factor receptor-1.", "Thermodynamic and structural description of allosterically regulated VEGFR-2 dimerization.", "Structural and mechanistic insights into VEGF receptor 3 ligand binding and activation.", ...

[ 2004, 2012, 2013, 2017, 2021, 2000 ]

6

[ "IPR003599" ]

[]

1

0

1

[ "Bilateria" ]

[ 8579 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 22, 19, 22, 26 ]

4

true

Domain

VEGFR1-3-like, N-terminal Ig-like domain

VEGFR1-3_N_Ig-like

2

IPR055239

55,239

Trans-sialidase, C-terminal domain

TS_C

Domain

4,009

false

This domain is found C-terminal in Trans-sialidase (TS) from Trypanosoma cruzi and other similar proteins. Members of this group are specific to Trypanosoma. TS is involved in host cell invasion and parasite survival in the bloodstream. The parasite uses TS activity to sialylate its own surface molecules, allowing it t...

[]

0

[ "PFAM" ]

[ "PF22925" ]

[ "TS_C" ]

[ 4009 ]

1

[ "EC" ]

[ "3.2.1.18" ]

[ "EC:3.2.1.18" ]

1

[ "1mr5", "1ms0", "1ms1", "1ms3", "1ms4", "1ms5", "1ms8", "1ms9", "1mz5", "1mz6", "1n1s", "1n1t", "1n1v", "1n1y", "1s0i", "1s0j", "1wcs", "2a75", "2ags", "2ah2", "2fhr", "3b69", "3opz", "3pjq" ]

24

[ "PUB00154302" ]

[ "35130274" ]

[ "Cooperativity of catalytic and lectin-like domain of Trypanosoma congolense trans-sialidase modulates its catalytic activity." ]

[ 2022 ]

1

[]

0

null

[ "Trypanosoma" ]

[ 4009 ]

1

[]

0

true

Domain

Trans-sialidase, C-terminal domain

TS_C

3

IPR055240

55,240

Alpha-galactosidase, CBM13 domain

CBM13-like

Domain

985

false

This is a carbohydrate-binding module family 13 domain that is found in beta-L-Arabinopyranosidase from Streptomyces avermitilis and similar sequences [ ].

[]

0

[ "PFAM" ]

[ "PF22704" ]

[ "CBM13-like" ]

[ 985 ]

1

[]

0

[ "3a21", "3a22", "3a23" ]

3

[ "PUB00054441", "PUB00054458" ]

[ "19218457", "19608743" ]

[ "Evidence that family 35 carbohydrate binding modules display conserved specificity but divergent function.", "A beta-l-Arabinopyranosidase from Streptomyces avermitilis is a novel member of glycoside hydrolase family 27." ]

[ 2009, 2009 ]

2

[]

0

null

[ "Bacteria", "Opisthokonta" ]

[ 614, 371 ]

2

[]

0

true

Domain

Alpha-galactosidase, CBM13 domain

CBM13-like

7

IPR055241

55,241

Armadillo-like repeats domain

Armadillo_rpt_dom

Domain

667

false

This entry represents a conserved region containing set of armadillo-like repeats found in uncharacterised plant proteins. Its function is not known.

[]

0

[ "PFAM" ]

[ "PF22915" ]

[ "ARMH5" ]

[ 667 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Flavobacteriaceae", "Viridiplantae" ]

[ 3, 664 ]

2

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 5, 3, 5 ]

3

true

Domain

Armadillo-like repeats domain

Armadillo_rpt_dom

7

IPR055242

55,242

Lmo2446-like, N-terminal

Lmo2446-like_N

Domain

200

false

This domain is found at the N-terminal end of a group of bacterial proteins, including Lmo2446 protein from Listeria monocytogenes, a functionally uncharacterised extracellular lipidated protein. Lmo2446 contains a glycoside hydrolase 31 family (GH31) catalytic domain ( ) flanked by three structural β-domains. This dom...

[]

0

[ "PFAM" ]

[ "PF22681" ]

[ "Lmo2446-like_N" ]

[ 200 ]

1

[]

0

[ "4kmq", "4kwu", "5f7u", "5hpo", "5hxm", "5i0d" ]

6

[ "PUB00122106", "PUB00151839", "PUB00151840", "PUB00154928" ]

[ "12092816", "27819654", "28089449", "12400677" ]

[ "Cloning and sequencing of the genes encoding cyclic tetrasaccharide-synthesizing enzymes from Bacillus globisporus C11.", "Structure to function of an α-glucan metabolic pathway that promotes Listeria monocytogenes pathogenesis.", "Transferase Versus Hydrolase: The Role of Conformational Flexibility in Reactio...

[ 2002, 2016, 2017, 2002 ]

4

[]

0

null

[ "Bacteria", "hydrothermal vent metagenome" ]

[ 199, 1 ]

2

[]

0

true

Domain

Lmo2446-like, N-terminal

Lmo2446-like_N

1

IPR055243

55,243

Negative regulator of ofd1, C-terminal

Nro1_C

Domain

8

false

This entry represents the C-terminal region of fission yeast Negative regulator of ofd1 (Nro1), whose α-helices are grouped in six helical hairpins. This protein is a positive regulator of the stability of the N-terminal transcription factor domain (Sre1N) of sre1 which is released from the membrane and enters the nucl...

[]

0

[ "PFAM" ]

[ "PF22329" ]

[ "Nro1_C" ]

[ 8 ]

1

[]

0

[ "3msv", "3qtm", "3qtn" ]

3

[ "PUB00056187", "PUB00154119" ]

[ "21610214", "21481773" ]

[ "Structural and functional analysis of Nro1/Ett1: a protein involved in translation termination in S. cerevisiae and in O2-mediated gene control in S. pombe.", "The hypoxic regulator of sterol synthesis nro1 is a nuclear import adaptor." ]

[ 2011, 2011 ]

2

[]

0

null

[ "Fungi" ]

[ 8 ]

1

[ "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1 ]

1

true

Domain

Negative regulator of ofd1, C-terminal

Nro1_C

4

IPR055244

55,244

DNA double-strand break repair protein Mre11, C-terminal Rad50-binding domain, archaea

Mre11_C_arc

Domain

8

false

Communication between Mre11 and Rad50 in the MR complex is critical for the sensing, damage signalling, and repair of DNA double-strand breaks. Mre11 protein consists of an N-terminal core domain and a C-terminal domain linked by an extended connecting loop. The C-terminal domain of Mre11 (this entry) is composed of th...

[]

0

[ "PFAM" ]

[ "PF22226" ]

[ "Mre11_C" ]

[ 8 ]

1

[]

0

[ "3av0", "5dny", "5f3w" ]

3

[ "PUB00154078" ]

[ "26717941" ]

[ "ATP-dependent DNA binding, unwinding, and resection by the Mre11/Rad50 complex." ]

[ 2016 ]

1

[]

0

null

[ "Methanocaldococcaceae" ]

[ 8 ]

1

[]

0

true

Domain

DNA double-strand break repair protein Mre11, C-terminal Rad50-binding domain, archaea

Mre11_C_arc

3

IPR055245

55,245

Winged helix-turn-helix domain, proteobacterial-type

HTH_proteobacteria

Domain

1,273

false

This winged helix-turn-helix domain is often found in proteobacteria and some phage proteins. It is likely to be involved in DNA-binding.

[]

0

[ "PFAM" ]

[ "PF14090" ]

[ "HTH_39" ]

[ 1273 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Candidatus Methanodesulfokora washburnensis", "Opisthokonta", "Viruses", "metagenomes" ]

[ 1113, 1, 4, 106, 49 ]

5

[]

0

true

Domain

Winged helix-turn-helix domain, proteobacterial-type

HTH_proteobacteria

9

IPR055246

55,246

Topoisomerase V, HHH domain

TopoV_HHH

Domain

2

false

This entry represents a helix-hairpin-helix (HHH) domain of topoisomerase V (Topo-V, ), the only member of a novel topoisomerase subtype. Topo-V is unique as it is a bifunctional enzyme carrying both topoisomerase and DNA repair lyase activities within the same protein [ , ]. This protein contains a topoisomerase domai...

[]

0

[ "PFAM" ]

[ "PF22409" ]

[ "TopoV_HHH" ]

[ 2 ]

1

[]

0

[ "4gfj", "5hm5", "8df7", "8df8", "8df9", "8dfb" ]

6

[ "PUB00064037", "PUB00151856" ]

[ "23125368", "26908655" ]

[ "Identification of one of the apurinic/apyrimidinic lyase active sites of topoisomerase V by structural and functional studies.", "Methanopyrus kandleri topoisomerase V contains three distinct AP lyase active sites in addition to the topoisomerase active site." ]

[ 2013, 2016 ]

2

[]

0

null

[ "Methanopyrus kandleri" ]

[ 2 ]

1

[]

0

true

Domain

Topoisomerase V, HHH domain

TopoV_HHH

9

IPR055247

55,247

Insertion element IS150 protein InsJ-like, helix-turn-helix domain

InsJ-like_HTH

Domain

16,721

false

This entry represents a helix-turn-helix (HTH) domain found in Insertion element IS150 protein InsJ from Escherichia coli and similar sequences from cellular organisms, mainly bacteria. It is likely to be DNA-binding.

[]

0

[ "PFAM" ]

[ "PF13518" ]

[ "HTH_28" ]

[ 16721 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 80, 14785, 1547, 58, 251 ]

5

[ "Drosophila melanogaster", "Escherichia coli (strain K12)" ]

[ 1, 1 ]

2

true

Domain

Insertion element IS150 protein InsJ-like, helix-turn-helix domain

InsJ-like_HTH

7

IPR055248

55,248

PSV, transcriptional regulator domain

PSV_trans_reg_dom

Domain

2

false

This domain is found in Transcriptional regulator from Pyrobaculum spherical virus (PSV) and similar viral proteins. It shows a winged-helix configuration [ ].

[]

0

[ "PFAM" ]

[ "PF22376" ]

[ "PSV_trans_reg_dom" ]

[ 2 ]

1

[]

0

[ "2vxz" ]

1

[ "PUB00054436" ]

[ "20419351" ]

[ "The Scottish Structural Proteomics Facility: targets, methods and outputs." ]

[ 2010 ]

1

[]

0

null

[ "Pyrobaculum spherical virus (isolate United States/Yellowstone)" ]

[ 2 ]

1

[]

0

true

Domain

PSV, transcriptional regulator domain

PSV_trans_reg_dom

8

IPR055249

55,249

Crb2, Tudor domain, schizosaccharomyces

Crb2_Tudor_schizosaccharomyces

Domain

4

false

This entry represents a Tudor domain in the DNA repair protein Crb2 from Schizosaccharomyces pombe [ ]. Crb2 possesses tandem Tudor domains which interact with histone H4 dimethylated at Lys20 (H4-K20me2). Crb2 is a checkpoint mediator required for the cellular response to DNA damage [ ].

[]

0

[ "PFAM", "CDD" ]

[ "PF22520", "cd20396" ]

[ "Crb2_Tudor", "Tudor_SpCrb2-like_rpt2" ]

[ 4, 4 ]

2

[ "REACTOME", "REACTOME" ]

[ "R-SPO-3232118", "R-SPO-5693565" ]

[ "REACTOME:R-SPO-3232118", "REACTOME:R-SPO-5693565" ]

2

[ "2fhd" ]

1

[ "PUB00040667", "PUB00049944", "PUB00058015", "PUB00102334", "PUB00139175", "PUB00145226", "PUB00145227", "PUB00145228", "PUB00145229", "PUB00145230", "PUB00145231" ]

[ "17190600", "18676809", "15550243", "22792081", "9407031", "9153313", "10488332", "16314498", "16778077", "18826944", "20679485" ]

[ "Structural basis for the methylation state-specific recognition of histone H4-K20 by 53BP1 and Crb2 in DNA repair.", "Structural and functional analysis of the Crb2-BRCT2 domain reveals distinct roles in checkpoint signaling and DNA damage repair.", "Methylation of histone H4 lysine 20 controls recruitment of ...

[ 2006, 2008, 2004, 2012, 1997, 1997, 1999, 2005, 2006, 2008, 2010 ]

11

[]

0

null

[ "Schizosaccharomyces" ]

[ 4 ]

1

[ "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1 ]

1

true

Domain

Crb2, Tudor domain, schizosaccharomyces

Crb2_Tudor_schizosaccharomyces

8

IPR055252

55,252

Class III superoxide reductase, N-terminal

SOR_N

Domain

6

false

This short domain is found at the N-terminal of class III superoxide reductase from Treponema pallidum (SOR, ), a small protein that catalyses the one-electron reduction of superoxide to hydrogen peroxide, having rubredoxin as their putative electron donor. It is organised into two distinct domains: an N-terminal domai...

[]

0

[ "PFAM" ]

[ "PF22496" ]

[ "SOR_N" ]

[ 6 ]

1

[]

0

[ "1y07" ]

1

[ "PUB00038396" ]

[ "16791639" ]

[ "The first crystal structure of class III superoxide reductase from Treponema pallidum." ]

[ 2006 ]

1

[]

0

null

[ "Treponema" ]

[ 6 ]

1

[]

0

true

Domain

Class III superoxide reductase, N-terminal

SOR_N

9

IPR055253

55,253

Argonaute, N-terminal domain, thermococcales

Ago_N_thermococcales

Domain

4

false

This domain is found at the N-terminal of Protein argonaute from Pyrococcus furiosus (Ago), a component of the RNAi effector complex (RISC). Ago is organised into four domains: N (this entry), PAZ ( ), middle and PIWI ( ). This domain shows a small four-stranded β-sheet, three α-helices and a β-hairpin [ ]. Members of ...

[]

0

[ "PFAM" ]

[ "PF22476" ]

[ "Ago_N_3" ]

[ 4 ]

1

[]

0

[ "1u04", "1z25", "1z26", "8jpx", "8jsi", "8wd8" ]

6

[ "PUB00020128", "PUB00038714" ]

[ "15284453", "15800637" ]

[ "Crystal structure of Argonaute and its implications for RISC slicer activity.", "Purified Argonaute2 and an siRNA form recombinant human RISC." ]

[ 2004, 2005 ]

2

[]

0

null

[ "Thermococcaceae" ]

[ 4 ]

1

[]

0

true

Domain

Argonaute, N-terminal domain, thermococcales

Ago_N_thermococcales

8

IPR055254

55,254

pPIWI_RE three-gene island, domain Z

pPIWI_RE_Z

Domain

524

false

This entry represents a poorly-understood bacterial domain observed N-terminal to DinG-type helicase, which is part of a conserved three-gene island also containing a REase domain and the pPIWI_RE module. This three gene island is predicted to form a conflict system which targets R-loop formation of invasive plasmids d...

[]

0

[ "PFAM" ]

[ "PF18155" ]

[ "pPIWI_RE_Z" ]

[ 524 ]

1

[]

0

[]

0

[ "PUB00091016" ]

[ "23758928" ]

[ "Two novel PIWI families: roles in inter-genomic conflicts in bacteria and Mediator-dependent modulation of transcription in eukaryotes." ]

[ 2013 ]

1

[]

0

null

[ "Bacteria", "bioreactor metagenome" ]

[ 523, 1 ]

2

[]

0

true

Domain

pPIWI_RE three-gene island, domain Z

pPIWI_RE_Z

9

IPR055255

55,255

Reticulophagy regulator 1, N-terminal reticulon-homology domain

RETR1_RHD

Domain

296

false

This entry represents the N-terminal reticulon-homology domain (RHD) of RETREG1/FAM134B, which shows sequence similarity to ADP-ribosylation factor-like 6 binding factor 1 (Arl6IP1 or Arl6ip-1), an ER protein that has an important role in cell conduction and material transport. This domain may function in inducing memb...

[]

0

[ "CDD" ]

[ "cd22560" ]

[ "RETR1_RHD" ]

[ 296 ]

1

[]

0

[]

0

[ "PUB00078530", "PUB00078532", "PUB00145493", "PUB00145494", "PUB00145495", "PUB00145496", "PUB00145497", "PUB00145498", "PUB00145499", "PUB00145500", "PUB00150570" ]

[ "26040720", "23939472", "29226326", "31147549", "31446166", "28102736", "29964340", "30291780", "28144752", "30559329", "30556279" ]

[ "Regulation of endoplasmic reticulum turnover by selective autophagy.", "Novel genes FAM134C, C3orf10 and ENOX1 are regulated by NRF-1 and differentially regulate neurite outgrowth in neuroblastoma cells and hippocampal neurons.", "RETREG1 (FAM134B): A new player in human diseases: 15 years after the discovery ...

[ 2015, 2013, 2018, 2019, 2019, 2017, 2018, 2019, 2017, 2019, 2019 ]

11

[ "IPR057282" ]

[]

1

0

1

[ "Euteleostomi" ]

[ 296 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 3, 1, 1 ]

4

true

Domain

Reticulophagy regulator 1, N-terminal reticulon-homology domain

RETR1_RHD

3

IPR055256

55,256

KHDC4/BBP-like, KH-domain type I

KH_1_KHDC4/BBP-like

Domain

22,301

false

This entry represents an eukaryotic type I KH domain found in a group of proteins involved in pre-mRNA splicing, such as KH domain-containing BBP from fungi, KH homology domain-containing protein 4 (KHDC4, also known as BLOM7) and Splicing factor 1 from animals, animal quaking proteins such as human QKI, and homologues...

[]

0

[ "PFAM" ]

[ "PF22675" ]

[ "KH-I_KHDC4-BBP" ]

[ 22301 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-DRE-8849468", "R-HSA-6802952", "R-HSA-72163", "R-HSA-8849468", "R-MMU-72163", "R-MMU-8849468", "R-RNO-8849468", "R-XTR-8849468" ]

[ "REACTOME:R-DRE-8849468", "REACTOME:R-HSA-6802952", "REACTOME:R-HSA-72163", "REACTOME:R-HSA-8849468", "REACTOME:R-MMU-72163", "REACTOME:R-MMU-8849468", "REACTOME:R-RNO-8849468", "REACTOME:R-XTR-8849468" ]

8

[ "1k1g", "2bl5", "2mjh", "2yqr", "4jvh", "4jvy", "4wal", "4wan", "5el3", "5elr", "5els", "5elt", "5emo", "7vpx", "7z89", "7z8a", "7z9a", "7z9b", "7zab", "7zac", "7zaf", "7zam" ]

22

[ "PUB00026613", "PUB00032783", "PUB00067019", "PUB00074396", "PUB00074790", "PUB00074791", "PUB00074792", "PUB00074794", "PUB00086864", "PUB00086865", "PUB00115590", "PUB00154028", "PUB00155953", "PUB00155954", "PUB00155955", "PUB00155956" ]

[ "11691992", "15811367", "23630077", "16243907", "12374752", "10775271", "21189690", "9660765", "19641227", "23144703", "25587180", "24838563", "25768908", "31829086", "34428287", "37379838" ]

[ "Structural basis for recognition of the intron branch site RNA by splicing factor 1.", "Solution structure and backbone dynamics of the KH-QUA2 region of the Xenopus STAR/GSG quaking protein.", "Structure-function studies of STAR family Quaking proteins bound to their in vivo RNA target sites.", "Maize rough...

[ 2001, 2005, 2013, 2005, 2002, 2000, 2010, 1998, 2009, 2012, 2015, 2014, 2015, 2020, 2021, 2023 ]

16

[]

[ "IPR047889" ]

0

1

0

[ "Eukaryota" ]

[ 22301 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 31, 10, 40, 29, 25, 15, 2, 27, 32, 1, 2, 75 ]

12

true

Domain

KHDC4/BBP-like, KH-domain type I

KH_1_KHDC4/BBP-like

1

IPR055257

55,257

Reticulophagy regulator 2, N-terminal reticulon-homology domain

RETR2_RHD

Domain

260

false

This entry represents the N-terminal reticulon-homology domain (RHD) of RETREG2/FAM134A, which shows sequence similarity to ADP-ribosylation factor-like 6 binding factor 1 (Arl6IP1 or Arl6ip-1), an endoplasmic reticulum protein that has an important role in cell conduction and material transport. The RHD may function i...

[]

0

[ "CDD" ]

[ "cd22561" ]

[ "RETR2_RHD" ]

[ 260 ]

1

[]

0

[]

0

[ "PUB00078530", "PUB00078532", "PUB00145494", "PUB00145501", "PUB00150571", "PUB00150572" ]

[ "26040720", "23939472", "31147549", "29440427", "29097687", "23474461" ]

[ "Regulation of endoplasmic reticulum turnover by selective autophagy.", "Novel genes FAM134C, C3orf10 and ENOX1 are regulated by NRF-1 and differentially regulate neurite outgrowth in neuroblastoma cells and hippocampal neurons.", "Curvature induction and membrane remodeling by FAM134B reticulon homology domain...

[ 2015, 2013, 2019, 2018, 2017, 2013 ]

6

[ "IPR057282" ]

[]

1

0

1

[ "Gnathostomata" ]

[ 260 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 1, 1, 5 ]

4

true

Domain

Reticulophagy regulator 2, N-terminal reticulon-homology domain

RETR2_RHD

7

IPR055258

55,258

Reticulophagy regulator 3, N-terminal reticulon-homology domain

RETR3_RHD

Domain

271

false

This entry represents the N-terminal reticulon-homology domain (RHD) of RETREG3/FAM134C, which shows sequence similarity to ADP-ribosylation factor-like 6 binding factor 1 (Arl6IP1 or Arl6ip-1), an endoplasmic reticulum protein that has an important role in cell conduction and material transport. The RHD may function i...

[]

0

[ "CDD" ]

[ "cd22562" ]

[ "RETR3_RHD" ]

[ 271 ]

1

[]

0

[]

0

[ "PUB00078530", "PUB00078532", "PUB00145494", "PUB00150573" ]

[ "26040720", "23939472", "31147549", "29850813" ]

[ "Regulation of endoplasmic reticulum turnover by selective autophagy.", "Novel genes FAM134C, C3orf10 and ENOX1 are regulated by NRF-1 and differentially regulate neurite outgrowth in neuroblastoma cells and hippocampal neurons.", "Curvature induction and membrane remodeling by FAM134B reticulon homology domain...

[ 2015, 2013, 2019, 2018 ]

4

[ "IPR057282" ]

[]

1

0

1

[ "Gnathostomata" ]

[ 271 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 1, 1, 1 ]

4

true

Domain

Reticulophagy regulator 3, N-terminal reticulon-homology domain

RETR3_RHD

1

IPR055259

55,259

Spore protein YkvP/CgeB, glycosyl transferase-like domain

YkvP/CgeB_Glyco_trans-like

Domain

13,283

false

This entry represents a glycosyl transferase-like domain found in spore protein YkvP and protein CgeB from Bacillus subtilis [ , ]. YkvP is a spore protein that contains a motif conserved among cell wall binding proteins. Its expression is dependent on both SigK and GerE transcription factors. YkvP is intrinsic to matu...

[]

0

[ "PFAM" ]

[ "PF13524" ]

[ "Glyco_trans_1_2" ]

[ 13283 ]

1

[]

0

[]

0

[ "PUB00057269", "PUB00062761", "PUB00160290" ]

[ "7592393", "11011148", "31502725" ]

[ "Adjacent and divergently oriented operons under the control of the sporulation regulatory protein GerE in Bacillus subtilis.", "Synthesis and characterization of the spore proteins of Bacillus subtilis YdhD, YkuD, and YkvP, which carry a motif conserved among cell wall binding proteins.", "The Bacillus subtili...

[ 1995, 2000, 2019 ]

3

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "metagenomes" ]

[ 119, 12516, 256, 47, 345 ]

5

[]

0

true

Domain

Spore protein YkvP/CgeB, glycosyl transferase-like domain

YkvP/CgeB_Glyco_trans-like

5

IPR055260

55,260

Kinetochore protein Ndc80, CH domain

Ndc80_CH

Domain

4,438

false

This entry represents the calponin homology (CH) domain found towards the N terminus of Ndc80 proteins, a component of the NMS (Ndc80-MIND-Spc7) super complex which has a role in kinetochore function during late meiotic prophase and throughout the mitotic cell cycle [ ]. This complex is required for chromosome segregat...

[]

0

[ "PFAM" ]

[ "PF03801" ]

[ "Ndc80_HEC" ]

[ 4438 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-GGA-141444", "R-GGA-2467813", "R-GGA-2500257", "R-GGA-5663220", "R-GGA-9648025", "R-HSA-141444", "R-HSA-2467813", "R-HSA-2500257", "R-HSA-5663220", "R-HSA-68877", "R-HSA-9648025", "R-MMU-141444", "R-MMU-2467813", "R-MMU-2500257", "R-MMU-5663220", "R-MMU-68877", "R-MMU-9648025", ...

[ "REACTOME:R-GGA-141444", "REACTOME:R-GGA-2467813", "REACTOME:R-GGA-2500257", "REACTOME:R-GGA-5663220", "REACTOME:R-GGA-9648025", "REACTOME:R-HSA-141444", "REACTOME:R-HSA-2467813", "REACTOME:R-HSA-2500257", "REACTOME:R-HSA-5663220", "REACTOME:R-HSA-68877", "REACTOME:R-HSA-9648025", "REACTOME:R-...

23

[ "2igp", "2ve7", "3iz0", "5tcs", "5td8", "7kdf", "8g0q", "8q84", "8q85", "8qau", "8v10", "8v11" ]

12

[ "PUB00008439", "PUB00077598", "PUB00088250", "PUB00088267", "PUB00154934", "PUB00154935", "PUB00154936", "PUB00154937" ]

[ "11266451", "23085020", "15548592", "27851957", "23891108", "25743205", "30409912", "36883282" ]

[ "The Ndc80p complex from Saccharomyces cerevisiae contains conserved centromere components and has a function in chromosome segregation.", "The kinetochore-bound Ska1 complex tracks depolymerizing microtubules and binds to curved protofilaments.", "Hec1 and nuf2 are core components of the kinetochore outer plat...

[ 2001, 2012, 2005, 2016, 2013, 2015, 2019, 2023 ]

8

[]

0

null

[ "Eukaryota" ]

[ 4438 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 2, 1, 2, 1, 4, 2, 1, 3, 4, 1, 1, 7 ]

12

true

Domain

Kinetochore protein Ndc80, CH domain

Ndc80_CH

2

IPR055261

55,261

Phosphatidylinositol transfer protein, N-terminal

PI_transfer_N

Domain

12,504

false

This entry represents the N-terminal domain of phosphatidylinositol transfer proteins (PITPs) which catalyse the transfer of phosphatidylinositol (PI) or phosphatidylcholine (PC) between membranes [ , , , , , ]. There are three sub-families - all share an N-terminal PITP-like domain, whose sequence is highly conserved....

[]

0

[ "PFAM" ]

[ "PF02121" ]

[ "IP_trans" ]

[ 12504 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-1483196", "R-DDI-1483196", "R-DME-1483226", "R-HSA-1483196", "R-HSA-1483226", "R-HSA-418890", "R-HSA-8950505", "R-MMU-1483196", "R-MMU-1483226", "R-RNO-1483196", "R-RNO-1483226" ]

[ "REACTOME:R-BTA-1483196", "REACTOME:R-DDI-1483196", "REACTOME:R-DME-1483226", "REACTOME:R-HSA-1483196", "REACTOME:R-HSA-1483226", "REACTOME:R-HSA-418890", "REACTOME:R-HSA-8950505", "REACTOME:R-MMU-1483196", "REACTOME:R-MMU-1483226", "REACTOME:R-RNO-1483196", "REACTOME:R-RNO-1483226" ]

11

[ "1kcm", "1t27", "1uw5", "2a1l", "8pqo" ]

5

[ "PUB00000922", "PUB00019748", "PUB00039104", "PUB00122281", "PUB00155085", "PUB00155086" ]

[ "7774006", "11574064", "16274224", "10531358", "18636990", "22822086" ]

[ "Signal transduction and membrane traffic: the PITP/phosphoinositide connection.", "The PITP family of phosphatidylinositol transfer proteins.", "Structure of PITPbeta in complex with phosphatidylcholine: comparison of structure and lipid transfer to other PITP isoforms.", "Cloning and characterization of a n...

[ 1995, 2001, 2005, 1999, 2008, 2012 ]

6

[]

0

null

[ "Eukaryota", "Megaviricetes" ]

[ 12501, 3 ]

2

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 3, 26, 12, 31, 20, 5, 25, 6 ]

8

true

Domain

Phosphatidylinositol transfer protein, N-terminal

PI_transfer_N

1

IPR055262

55,262

Gamma-glutamyltranspeptidase, conserved site

GGT_CS

Conserved_site

9,911

false

This entry represents a conserved site of GGTs. Gamma-glutamyltranspeptidase ( ) (GGT) [ ] catalyses the transfer of the gamma-glutamyl moiety of glutathione to an acceptor that may be an amino acid, a peptide or water (forming glutamate). GGT plays a key role in the gamma-glutamyl cycle, a pathway for the synthesis an...

[]

0

[ "PROSITE" ]

[ "PS00462" ]

[ "G_GLU_TRANSPEPTIDASE" ]

[ 9911 ]

1

[ "EC", "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "...

[ "2.3.2.2", "3.4.19.13", "PWY-4041", "PWY-4061", "PWY-5826", "PWY-6842", "PWY-7112", "PWY-7559", "PWY-8001", "PWY-8301", "PWY-8355", "R-HSA-174403", "R-HSA-2142691", "R-HSA-5423646", "R-HSA-5579022", "R-HSA-9035968", "R-HSA-9664535", "R-HSA-9753281", "R-MMU-174403", "R-MMU-21426...

[ "EC:2.3.2.2", "EC:3.4.19.13", "METACYC:PWY-4041", "METACYC:PWY-4061", "METACYC:PWY-5826", "METACYC:PWY-6842", "METACYC:PWY-7112", "METACYC:PWY-7559", "METACYC:PWY-8001", "METACYC:PWY-8301", "METACYC:PWY-8355", "REACTOME:R-HSA-174403", "REACTOME:R-HSA-2142691", "REACTOME:R-HSA-5423646", "...

30

[ "2dbu", "2dbw", "2dbx", "2dg5", "2e0x", "2e0y", "2nqo", "2qm6", "2v36", "2z8i", "2z8j", "2z8k", "3a75", "3fnm", "3whq", "3whr", "3whs", "4gdx", "4gg2", "4ott", "4otu", "4z9o", "4zbk", "4zc6", "4zcg", "5b5t", "5bpk", "5v4q", "5xlu", "5y8x", "5y9b", "5zjg"...

40

[ "PUB00000636", "PUB00002088", "PUB00003561", "PUB00006169", "PUB00092777" ]

[ "1358202", "2570061", "2868390", "1378736", "23148443" ]

[ "Nucleotide sequence and expression in Escherichia coli of the cephalosporin acylase gene of a Pseudomonas strain.", "DNA sequence of the Escherichia coli K-12 gamma-glutamyltranspeptidase gene, ggt.", "gamma-Glutamyl transpeptidase from kidney.", "Gamma-glutamyltransferase: nucleotide sequence of the human p...

[ 1992, 1989, 1985, 1992, 2012 ]

5

[]

0

null

[ "Bacteria", "Eukaryota", "Halococcaceae", "metagenomes" ]

[ 7112, 2717, 5, 77 ]

4

[ "Caenorhabditis elegans", "Danio rerio", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)" ]

[ 2, 8, 1, 20, 5, 6, 1 ]

7

true

Conserved_site

Gamma-glutamyltranspeptidase, conserved site

GGT_CS

5

IPR055264

55,264

BOD1/SHG1 domain

BOD1/SHG1_dom

Domain

4,279

false

This domain is found at the N-terminal of Biorientation of chromosomes in cell division protein 1-like 1 (BODL1) from animals, and covers the whole length of the protein sequence in its paralogues BD1L2/BOD1 and the orthologues from yeast SHG1. BOD1L1 is a component of the fork protection machinery required to protect ...

[]

0

[ "PFAM" ]

[ "PF05205" ]

[ "COMPASS-Shg1" ]

[ 4279 ]

1

[ "REACTOME", "REACTOME" ]

[ "R-HSA-9772755", "R-MMU-9772755" ]

[ "REACTOME:R-HSA-9772755", "REACTOME:R-MMU-9772755" ]

2

[]

0

[ "PUB00033368", "PUB00056115", "PUB00093807", "PUB00153020", "PUB00153021" ]

[ "11805083", "17938248", "26889944", "26166705", "29937342" ]

[ "COMPASS, a histone H3 (Lysine 4) methyltransferase required for telomeric silencing of gene expression.", "Bod1, a novel kinetochore protein required for chromosome biorientation.", "Protection or resection: BOD1L as a novel replication fork protection factor.", "BOD1L Is Required to Suppress Deleterious Res...

[ 2002, 2007, 2016, 2015, 2018 ]

5

[]

0

null

[ "Eukaryota" ]

[ 4279 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strai...

[ 2, 3, 3, 8, 3, 1, 7, 1, 1 ]

9

true

Domain

BOD1/SHG1 domain

BOD1/SHG1_dom

4

IPR055265

55,265

Photosynthetic reaction centre, L/M, conserved site

Photo_RC_L/M_CS

Conserved_site

43,479

false

This entry represents a conserved site found in this group of proteins which includes two conserved histidine residues. In L and M chains, the first histidine is a ligand of the magnesium ion of the special pair bacteriochlorophyll, the second is a ligand of a ferrous non-haem iron atom. In photosystem II these two his...

[]

0

[ "PROSITE" ]

[ "PS00244" ]

[ "REACTION_CENTER" ]

[ 43479 ]

1

[ "EC", "METACYC" ]

[ "1.10.3.9", "PWY-101" ]

[ "EC:1.10.3.9", "METACYC:PWY-101" ]

2

[ "1aig", "1aij", "1ds8", "1dv3", "1dv6", "1dxr", "1e14", "1e6d", "1eys", "1f6n", "1fnp", "1fnq", "1izl", "1jgw", "1jgx", "1jgy", "1jgz", "1jh0", "1k6l", "1k6n", "1kby", "1l9b", "1l9j", "1m3x", "1mps", "1ogv", "1pcr", "1prc", "1pss", "1pst", "1qov", "1r2c"...

395

[ "PUB00015357", "PUB00015359", "PUB00082625" ]

[ "12518057", "14871485", "27386923" ]

[ "Crystal structure of oxygen-evolving photosystem II from Thermosynechococcus vulcanus at 3.7-A resolution.", "The low molecular mass subunits of the photosynthetic supracomplex, photosystem II.", "Light-dependent chlorophyll f synthase is a highly divergent paralog of PsbA of photosystem II." ]

[ 2003, 2004, 2016 ]

3

[]

0

null

[ "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 3534, 37082, 1312, 1551 ]

4

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 11, 13, 9 ]

3

true

Conserved_site

Photosynthetic reaction centre, L/M, conserved site

Photo_RC_L/M_CS

6

IPR055266

55,266

Photosystem II protein D1/D2

D1/D2

Family

44,669

false

This entry includes D1 (PsbA) and D2 (PsbD) photosystem II (PSII) reaction centre proteins from cyanobacteria, algae and plants. The D1 and D2 proteins only show approximately 15% sequence homology with the L and M subunits, however the conserved amino acids correspond to the binding sites of the phytochemically active...

[]

0

[ "PANTHER" ]

[ "PTHR33149" ]

[ "" ]

[ 44669 ]

1

[ "EC", "METACYC" ]

[ "1.10.3.9", "PWY-101" ]

[ "EC:1.10.3.9", "METACYC:PWY-101" ]

2

[ "1izl", "1s5l", "1w5c", "2axt", "3a0b", "3a0h", "3jcu", "3kzi", "3wu2", "4fby", "4il6", "4ixq", "4ixr", "4pbu", "4pj0", "4rvy", "4tnh", "4tni", "4tnj", "4tnk", "4ub6", "4ub8", "4v62", "4v82", "4yuu", "5b5e", "5b66", "5e79", "5e7c", "5gth", "5gti", "5h2f"...

169

[ "PUB00015357", "PUB00015359", "PUB00082625" ]

[ "12518057", "14871485", "27386923" ]

[ "Crystal structure of oxygen-evolving photosystem II from Thermosynechococcus vulcanus at 3.7-A resolution.", "The low molecular mass subunits of the photosynthetic supracomplex, photosystem II.", "Light-dependent chlorophyll f synthase is a highly divergent paralog of PsbA of photosystem II." ]

[ 2003, 2004, 2016 ]

3

[ "IPR000484" ]

[ "IPR005867", "IPR005868" ]

1

2

0

[ "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 1784, 39760, 1555, 1570 ]

4

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 11, 18, 12 ]

3

true

Family

Photosystem II protein D1/D2

D1/D2

9

IPR055267

55,267

Aerolysin-like, C-terminal

Aerolysin-like_C

Domain

1,290

false

This entry represents the C-terminal region of Aerolysin from Aeromonas sobria and similar sequences mainly from proteobacteria, animals and plants. This protein is a cytolytic toxin that forms pores in host membranes after proteolytic removal of a C-terminal propeptide, leading to destruction of the membrane permeabil...

[]

0

[ "PFAM", "SMART" ]

[ "PF01117", "SM00999" ]

[ "Aerolysin", "Aerolysin" ]

[ 1289, 500 ]

2

[]

0

[ "1pre", "1z52", "3c0m", "3c0n", "3c0o", "3g4n", "3g4o", "5jzh", "5jzt", "5jzw", "9fm6", "9fml", "9fmx", "9fnp", "9fnq", "9gxj" ]

16

[ "PUB00149633", "PUB00155202" ]

[ "27405240", "1302284" ]

[ "Cryo-EM structure of aerolysin variants reveals a novel protein fold and the pore-formation process.", "Nucleotide sequences and characterization of haemolysin genes from Aeromonas hydrophila and Aeromonas sobria." ]

[ 2016, 1992 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 520, 768, 2 ]

3

[]

0

true

Domain

Aerolysin-like, C-terminal

Aerolysin-like_C

5

IPR055268

55,268

Pyruvate carboxylase-like

PCB-like

Family

26,414

false

This entry represents a group of enzymes involved in transfer of carboxyl group such as Pyruvate carboxylase, Oxaloacetate decarboxylase and Methylmalonyl-CoA carboxyltransferase. Pyruvate carboxylase (PCB) catalyses a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the f...

[]

0

[ "PANTHER" ]

[ "PTHR43778" ]

[ "" ]

[ 26414 ]

1

[ "EC", "METACYC", "METACYC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "RE...

[ "6.4.1.1", "PWY-6142", "PWY-6146", "PWY-8086", "R-BTA-196780", "R-BTA-70263", "R-BTA-70268", "R-CEL-196780", "R-CEL-70263", "R-CEL-70268", "R-HSA-196780", "R-HSA-3371599", "R-HSA-70263", "R-HSA-70268", "R-MMU-196780", "R-MMU-70263", "R-MMU-70268", "R-RNO-196780", "R-RNO-70263", ...

[ "EC:6.4.1.1", "METACYC:PWY-6142", "METACYC:PWY-6146", "METACYC:PWY-8086", "REACTOME:R-BTA-196780", "REACTOME:R-BTA-70263", "REACTOME:R-BTA-70268", "REACTOME:R-CEL-196780", "REACTOME:R-CEL-70263", "REACTOME:R-CEL-70268", "REACTOME:R-HSA-196780", "REACTOME:R-HSA-3371599", "REACTOME:R-HSA-70263...

26

[ "1rqb", "1rqe", "1rqh", "1rr2", "1s3h", "1u5j", "2dzd", "2nx9", "2qf7", "3bg3", "3bg5", "3bg9", "3hb9", "3hbl", "3ho8", "3tw6", "3tw7", "4hnt", "4hnu", "4hnv", "4jx4", "4jx5", "4jx6", "4loc", "4m6v", "4mfd", "4mfe", "4mim", "4qsh", "4qsk", "4qsl", "5ks8"...

56

[ "PUB00030767", "PUB00155209", "PUB00155210" ]

[ "15329673", "2556085", "4146915" ]

[ "Transcarboxylase 5S structures: assembly and catalytic mechanism of a multienzyme complex subunit.", "Isolation and characterization of oxaloacetate decarboxylase of Salmonella typhimurium, a sodium ion pump.", "Role of pyruvate carboxylase, phosphoenolpyruvate carboxykinase, and malic enzyme during growth and...

[ 2004, 1989, 1973 ]

3

[]

[ "IPR005776", "IPR005930" ]

0

2

0

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 308, 20407, 5379, 320 ]

4

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strai...

[ 2, 3, 4, 6, 11, 1, 5, 2, 1 ]

9

true

Family

Pyruvate carboxylase-like

PCB-like

7

IPR055269

55,269

Alpha crystallin/Heat shock protein Hsp-16.1/Hsp-16.2

Alpha-crystallin/HSP_16

Family

3,845

false

This entry represents a group of alpha-crystallin domain containing proteins from animals, including the A and B subunits of alpha-crystallin and related small heat shock proteins Hsp-16.1/Hsp-16.11/Hsp-16.2 elegans whose function is not yet clear. This entry also includes the Drosophila melanogaster small heat-shock-r...

[]

0

[ "PIRSF" ]

[ "PIRSF036514" ]

[ "Sm_HSP_B1" ]

[ 3845 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-3371571", "R-CEL-4420097", "R-DME-3371571", "R-DME-4420097", "R-DME-9009391", "R-GGA-3371571", "R-HSA-3371571", "R-MMU-3371571", "R-RNO-3371571", "R-SSC-3371571" ]

[ "REACTOME:R-BTA-3371571", "REACTOME:R-CEL-4420097", "REACTOME:R-DME-3371571", "REACTOME:R-DME-4420097", "REACTOME:R-DME-9009391", "REACTOME:R-GGA-3371571", "REACTOME:R-HSA-3371571", "REACTOME:R-MMU-3371571", "REACTOME:R-RNO-3371571", "REACTOME:R-SSC-3371571" ]

10

[ "2klr", "2ygd", "3j07", "6t1r", "9u4l" ]

5

[ "PUB00003917", "PUB00005345", "PUB00034659", "PUB00087792", "PUB00087815", "PUB00155221" ]

[ "7634077", "2688200", "15575808", "11875128", "10950306", "11908067" ]

[ "The structure of avian eye lens delta-crystallin reveals a new fold for a superfamily of oligomeric enzymes.", "Evolution of eye lens crystallins: the stress connection.", "alpha-crystallin: a review of its structure and function.", "Alpha-crystallin-type heat shock proteins: socializing minichaperones in th...

[ 1994, 1989, 2004, 2002, 2000, 2002 ]

6

[ "IPR001436" ]

[]

1

0

1

[ "Bacteria", "Bilateria" ]

[ 4, 3841 ]

2

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 4, 3, 2, 6, 4, 3 ]

6

true

Family

Alpha crystallin/Heat shock protein Hsp-16.1/Hsp-16.2

Alpha-crystallin/HSP_16

6

IPR055270

55,270

Fucosyltransferase, C-terminal

Glyco_tran_10_C

Domain

18,136

false

This is the C-terminal domain of a family of fucosyltransferases, known as glycosyltransferase family 10 [ , ]. This enzyme transfers fucose from GDP-Fucose to GlcNAc in an alpha(1,3) linkage [ , ]. The C-terminal Rossman-like domain is presumed to be involved in acceptor interactions [ ]

[]

0

[ "PFAM" ]

[ "PF00852" ]

[ "Glyco_transf_10" ]

[ 18136 ]

1

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "2.4.1", "R-BTA-9037629", "R-CEL-9037629", "R-CEL-975578", "R-CFA-9037629", "R-DME-9037629", "R-DME-975578", "R-HSA-5173105", "R-HSA-9037629", "R-HSA-975578", "R-MMU-5173105", "R-MMU-9037629", "R-RNO-5173105", "R-RNO-9037629", "R-XTR-5173105" ]

[ "EC:2.4.1", "REACTOME:R-BTA-9037629", "REACTOME:R-CEL-9037629", "REACTOME:R-CEL-975578", "REACTOME:R-CFA-9037629", "REACTOME:R-DME-9037629", "REACTOME:R-DME-975578", "REACTOME:R-HSA-5173105", "REACTOME:R-HSA-9037629", "REACTOME:R-HSA-975578", "REACTOME:R-MMU-5173105", "REACTOME:R-MMU-9037629",...

15

[ "2nzw", "2nzx", "2nzy", "5zoi", "7yro", "8d0o", "8d0p", "8d0q", "8d0r", "8d0s", "8d0u", "8d0w", "8d0x" ]

13

[ "PUB00001989", "PUB00009409", "PUB00075886", "PUB00155244", "PUB00155285", "PUB00155286" ]

[ "9451017", "9334165", "17251184", "19088067", "29593094", "37202521" ]

[ "Conserved structural features in eukaryotic and prokaryotic fucosyltransferases.", "A classification of nucleotide-diphospho-sugar glycosyltransferases based on amino acid sequence similarities.", "Structure and mechanism of Helicobacter pylori fucosyltransferase. A basis for lipopolysaccharide variation and i...

[ 1998, 1997, 2007, 2009, 2018, 2023 ]

6

[]

0

null

[ "Bacteria", "Eukaryota", "Methanobacteriota", "Viruses", "unclassified sequences" ]

[ 1412, 16477, 12, 61, 174 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 22, 5, 39, 9, 28, 18, 11, 20, 23 ]

9

true

Domain

Fucosyltransferase, C-terminal

Glyco_tran_10_C

4