interpro_id string | interpro_numeric_id int64 | name string | short_name string | entry_type string | protein_count int64 | is_llm bool | is_llm_reviewed bool | abstract string | go_ids list | go_terms list | go_categories list | go_count int64 | member_databases list | member_accessions list | member_names list | member_protein_counts list | member_count int64 | external_databases list | external_accessions list | external_xrefs list | external_xref_count int64 | pdb_ids list | structure_count int64 | publication_ids list | pubmed_ids list | publication_titles list | publication_years list | publication_count int64 | parent_ids list | child_ids list | parent_count int64 | child_count int64 | tree_depth float64 | taxonomy_names list | taxonomy_protein_counts list | taxonomy_count int64 | key_species_names list | key_species_protein_counts list | key_species_count int64 | in_entry_list bool | entry_list_type string | entry_list_name string | names_dat_name string | short_names_dat_name string | split_bucket int64 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
IPR056070 | 56,070 | Domain of unknown function DUF7653 | DUF7653 | Domain | 930 | false | false | This domain is found in uncharacterised proteins mainly from plants. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24670"
] | [
"DUF7653"
] | [
930
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Embryophyta"
] | [
930
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
10,
5,
5
] | 3 | true | Domain | Domain of unknown function DUF7653 | Domain of unknown function DUF7653 | DUF7653 | 4 |
IPR056071 | 56,071 | Domain of unknown function DUF7654 | DUF7654 | Domain | 478 | false | false | This domain is found in uncharacterised bacterial proteins. It is predicted to adopt a globular α/β structure. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24672"
] | [
"DUF7654"
] | [
478
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Methanobrevibacter",
"metagenomes"
] | [
460,
7,
11
] | 3 | [] | [] | 0 | true | Domain | Domain of unknown function DUF7654 | Domain of unknown function DUF7654 | DUF7654 | 3 |
IPR056073 | 56,073 | Domain of unknown function DUF7656 | DUF7656 | Domain | 539 | false | false | This domain is found in a group of uncharacterised eukaryotic proteins. It shares detectable similarity to the Thioredoxin-like SNTX domain (Pfam:PF18078) and it is predicted to adopt similar structure. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24676"
] | [
"DUF7656"
] | [
539
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
539
] | 1 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)"
] | [
1
] | 1 | true | Domain | Domain of unknown function DUF7656 | Domain of unknown function DUF7656 | DUF7656 | 6 |
IPR056074 | 56,074 | Domain of unknown function DUF7657 | DUF7657 | Domain | 538 | false | false | This domain is found in uncharacterised bacterial proteins. It contains a semi-conserved sequence motif TxYPGxR. It is likely that this domain is a transmembrane domain composed of α-helices. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24677"
] | [
"DUF7657"
] | [
538
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Methanobrevibacter",
"freshwater metagenome"
] | [
524,
7,
7
] | 3 | [] | [] | 0 | true | Domain | Domain of unknown function DUF7657 | Domain of unknown function DUF7657 | DUF7657 | 5 |
IPR056075 | 56,075 | Domain of unknown function DUF7658 | DUF7658 | Domain | 395 | false | false | This is a presumed domain found towards the C-terminal of a group of uncharacterised sequences from nematodes, including the uncharacterised protein F54D1.6 from Caenorhabditis elegans. This domain is found immediately N-terminal to . | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24678"
] | [
"DUF7658"
] | [
395
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Nematoda"
] | [
395
] | 1 | [
"Caenorhabditis elegans"
] | [
2
] | 1 | true | Domain | Domain of unknown function DUF7658 | Domain of unknown function DUF7658 | DUF7658 | 5 |
IPR056077 | 56,077 | Domain of unknown function DUF7660 | DUF7660 | Domain | 916 | false | false | This family represents a set of uncharacterised bacterial proteins. Structure prediction shows them to be composed of three α-helices. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24693"
] | [
"DUF7660"
] | [
916
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"metagenomes"
] | [
910,
6
] | 2 | [] | [] | 0 | true | Domain | Domain of unknown function DUF7660 | Domain of unknown function DUF7660 | DUF7660 | 8 |
IPR056078 | 56,078 | Domain of unknown function DUF7661 | DUF7661 | Domain | 577 | false | false | This entry represents a family of small uncharacterised bacterial proteins that adopts a compact domain composed of 5 β-strands and a single α-helix. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24697"
] | [
"DUF7661"
] | [
577
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria"
] | [
577
] | 1 | [] | [] | 0 | true | Domain | Domain of unknown function DUF7661 | Domain of unknown function DUF7661 | DUF7661 | 7 |
IPR056079 | 56,079 | Domain of unknown function DUF7662 | DUF7662 | Domain | 930 | false | false | This domain is found in uncharacterised bacterial proteins. It is frequently found in combination with and which suggests that it may be involved in DNA binding and recognition. It is predicted to adopt a globular structure consisting of a three-stranded antiparallel β-sheet and α-helices packed on one side of it. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24698"
] | [
"DUF7662"
] | [
930
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Chiloscyllium punctatum",
"ecological metagenomes"
] | [
23,
887,
1,
19
] | 4 | [] | [] | 0 | true | Domain | Domain of unknown function DUF7662 | Domain of unknown function DUF7662 | DUF7662 | 5 |
IPR056080 | 56,080 | Domain of unknown function DUF7663 | DUF7663 | Domain | 11 | false | false | This domain is found in uncharacterised bacterial proteins. It is frequently found in combination with . It is predicted to adopt a complex α/β structure composed of a curved β-sheet that encloses an α-helix and a number of helices packed on its exterior. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24699"
] | [
"DUF7663"
] | [
11
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Pseudomonadati",
"bioreactor metagenome"
] | [
10,
1
] | 2 | [] | [] | 0 | true | Domain | Domain of unknown function DUF7663 | Domain of unknown function DUF7663 | DUF7663 | 2 |
IPR056081 | 56,081 | Domain of unknown function DUF7664 | DUF7664 | Domain | 4 | false | false | This entry represents a small accessory domain found at the N-terminal of a small family of archaeal AGOG proteins. These proteins have 8-oxoguanine DNA glycosylase activity. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24701"
] | [
"DUF7664"
] | [
4
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaeoglobus",
"Natranaerobius thermophilus (strain ATCC BAA-1301 / DSM 18059 / JW/NM-WN-LF)"
] | [
3,
1
] | 2 | [] | [] | 0 | true | Domain | Domain of unknown function DUF7664 | Domain of unknown function DUF7664 | DUF7664 | 6 |
IPR056082 | 56,082 | Bacterial E2-like ubiquitin protein BilB-like | BilB-like | Family | 111 | false | false | This protein family includes Bacterial E2-like ubiquitin protein BilB from Collimonas sp. and similar short uncharacterised bacterial proteins. BilB is a component of the Bil (bacterial ISG15-like) antiviral defense system. BilB probably accepts ubiquitin from the BilA-BilD (E1) complex and catalyses its covalent attac... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24702"
] | [
"DUF7665"
] | [
111
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00160357"
] | [
"39020165"
] | [
"Bacteria conjugate ubiquitin-like proteins to interfere with phage assembly."
] | [
2024
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"ecological metagenomes"
] | [
109,
2
] | 2 | [] | [] | 0 | true | Family | Bacterial E2-like ubiquitin protein BilB-like | Bacterial E2-like ubiquitin protein BilB-like | BilB-like | 8 |
IPR056083 | 56,083 | Domain of unknown function DUF7666 | DUF7666 | Domain | 970 | false | false | This entry represents an uncharacterised protein domain that is sometimes found associated with . | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24703"
] | [
"DUF7666"
] | [
970
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Ranatra chinensis",
"Viruses",
"metagenomes"
] | [
766,
1,
182,
21
] | 4 | [] | [] | 0 | true | Domain | Domain of unknown function DUF7666 | Domain of unknown function DUF7666 | DUF7666 | 6 |
IPR056084 | 56,084 | Protein of unknown function DUF7667 | DUF7667 | Family | 297 | false | false | This entry represents a small family of uncharacterised bacterial proteins. Structure prediction shows these proteins are α-helical with a long central α-helix packed against two shorter N and C-terminal helices. Structure prediction suggests these proteins may form homodimers. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24704"
] | [
"DUF7667"
] | [
297
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacillales",
"Caudoviricetes"
] | [
281,
16
] | 2 | [] | [] | 0 | true | Family | Protein of unknown function DUF7667 | Protein of unknown function DUF7667 | DUF7667 | 9 |
IPR056085 | 56,085 | Domain of unknown function DUF7668 | DUF7668 | Domain | 364 | false | false | This entry represents a bacterial protein domain of unknown function. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24705"
] | [
"DUF7668"
] | [
364
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Tanacetum cinerariifolium"
] | [
363,
1
] | 2 | [] | [] | 0 | true | Domain | Domain of unknown function DUF7668 | Domain of unknown function DUF7668 | DUF7668 | 6 |
IPR056086 | 56,086 | Domain of unknown function DUF7669 | DUF7669 | Domain | 243 | false | false | This domain is found in a group of uncharacterised proteins primarily found in Bacteria. It has a detectable similarity to winged helix HTH domain and it is predicted to adopt similar structure. This domain is frequently found in combination with and . | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24706"
] | [
"DUF7669"
] | [
243
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Symbiodinium pilosum",
"ecological metagenomes"
] | [
20,
217,
1,
5
] | 4 | [] | [] | 0 | true | Domain | Domain of unknown function DUF7669 | Domain of unknown function DUF7669 | DUF7669 | 7 |
IPR056087 | 56,087 | Protein of unknown function DUF7670 | DUF7670 | Family | 196 | false | false | This entry represents a family of uncharacterised bacterial membrane proteins that contain four transmembrane α-helices. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24709"
] | [
"DUF7670"
] | [
196
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Promethearchaeum syntrophicum",
"ecological metagenomes"
] | [
182,
1,
13
] | 3 | [] | [] | 0 | true | Family | Protein of unknown function DUF7670 | Protein of unknown function DUF7670 | DUF7670 | 5 |
IPR056088 | 56,088 | Domain of unknown function DUF7671 | DUF7671 | Domain | 283 | false | false | This entry represents a family of uncharacterised bacterial proteins. The protein forms a single β-barrel domain which shows some structural similarity to the N-terminal domain of the PriA protein. However, structure prediction does not support this protein having a DNA-binding function like PriA. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24710"
] | [
"DUF7671"
] | [
283
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Lactobacillaceae"
] | [
283
] | 1 | [] | [] | 0 | true | Domain | Domain of unknown function DUF7671 | Domain of unknown function DUF7671 | DUF7671 | 3 |
IPR056089 | 56,089 | Domain of unknown function DUF7672 | DUF7672 | Domain | 35 | false | false | This entry represents a domain of unknown function in uncharacterised proteins found in bacteria (Bacteroidota and Chloroflexi). The proteins are likely to be integral membrane proteins with two transmembrane α-helices. Structural modelling suggests that these proteins form a dimeric arrangement with pairs of α helices... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24717"
] | [
"DUF7672"
] | [
35
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"marine metagenome"
] | [
34,
1
] | 2 | [] | [] | 0 | true | Domain | Domain of unknown function DUF7672 | Domain of unknown function DUF7672 | DUF7672 | 2 |
IPR056090 | 56,090 | Domain of unknown function DUF7673 | DUF7673 | Domain | 692 | false | false | This entry represents an uncharacterised family of proteins, which are typically between 100 and 122 amino acids in length. This protein is often found to be plasmid borne and in a few cases is associated with ParBc domains that are critical for plasmid segregation. This suggests that this domain may play a role in chr... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24720"
] | [
"DUF7673"
] | [
692
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Diploscapter pachys",
"Pseudomonadati",
"Viruses",
"ecological metagenomes"
] | [
1,
675,
6,
10
] | 4 | [] | [] | 0 | true | Domain | Domain of unknown function DUF7673 | Domain of unknown function DUF7673 | DUF7673 | 4 |
IPR056091 | 56,091 | Domain of unknown function DUF7674 | DUF7674 | Domain | 1,457 | false | false | This family of proteins is found in bacteria. Proteins in this family are typically between 113 and 127 amino acids in length. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24722"
] | [
"DUF7674"
] | [
1457
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Candidatus Methanoperedens nitratireducens",
"Eukaryota",
"metagenomes"
] | [
1438,
1,
2,
16
] | 4 | [] | [] | 0 | true | Domain | Domain of unknown function DUF7674 | Domain of unknown function DUF7674 | DUF7674 | 6 |
IPR056092 | 56,092 | Domain of unknown function DUF7675 | DUF7675 | Domain | 118 | false | false | This entry represents an uncharacterised family of proteins is found in bacteria and viruses. Proteins in this family are typically between 69 and 93 amino acids in length. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24723"
] | [
"DUF7675"
] | [
118
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Caudoviricetes"
] | [
109,
9
] | 2 | [] | [] | 0 | true | Domain | Domain of unknown function DUF7675 | Domain of unknown function DUF7675 | DUF7675 | 2 |
IPR056093 | 56,093 | Domain of unknown function DUF7676 | DUF7676 | Domain | 251 | false | false | This entry represents a family of bacterial proteins that based on structural similarities are likely to bind to heme or a related derivative molecule. Structural modelling suggests these proteins are likely to form homodimers and that this complex can bind to two heme-like molecules. Each heme binding site is composed... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24724"
] | [
"DUF7676"
] | [
251
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Geodia barretti",
"ecological metagenomes"
] | [
244,
1,
6
] | 3 | [] | [] | 0 | true | Domain | Domain of unknown function DUF7676 | Domain of unknown function DUF7676 | DUF7676 | 2 |
IPR056094 | 56,094 | Domain of unknown function DUF7677 | DUF7677 | Domain | 294 | false | false | This entry represents a group of uncharacterised proteins found in bacteria. These proteins are predicted to adopt globular structure that folds into a three helical bundle. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24725"
] | [
"DUF7677"
] | [
294
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Saccharomycotina",
"hydrothermal vent metagenome"
] | [
286,
5,
3
] | 3 | [] | [] | 0 | true | Domain | Domain of unknown function DUF7677 | Domain of unknown function DUF7677 | DUF7677 | 1 |
IPR056095 | 56,095 | Domain of unknown function DUF7678 | DUF7678 | Domain | 228 | false | false | This entry represents a conserved domain of unknown function found in various bacterial species. The domain is approximately 75-100 amino acids in length and contains several highly conserved residues. The function of this domain remains to be determined. Structure prediction suggests this domain is composed of a 6 str... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24726"
] | [
"DUF7678"
] | [
228
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Brugia timori",
"Caudoviricetes",
"ecological metagenomes"
] | [
196,
1,
17,
14
] | 4 | [] | [] | 0 | true | Domain | Domain of unknown function DUF7678 | Domain of unknown function DUF7678 | DUF7678 | 7 |
IPR056096 | 56,096 | Protein of unknown function DUF7679 | DUF7679 | Family | 262 | false | false | This entry represents a small family of Lactobacillus proteins of unknown function. The predicted structure suggests these proteins contain two subdomains, with an N-terminal partly open β barrel and C-terminal α/β subdomain. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24727"
] | [
"DUF7679"
] | [
262
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacillota"
] | [
262
] | 1 | [] | [] | 0 | true | Family | Protein of unknown function DUF7679 | Protein of unknown function DUF7679 | DUF7679 | 5 |
IPR056097 | 56,097 | Domain of unknown function DUF7680 | DUF7680 | Domain | 278 | false | false | This entry represents a group of uncharacterised prokaryotic proteins. These proteins share a common semi-conserved EExxWY sequence motif which is predicted as a solvent-exposed in a α/β structure consisting of a four-stranded antiparallel β-sheet and α-helices packed on one side of it. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24728"
] | [
"DUF7680"
] | [
278
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"ecological metagenomes"
] | [
70,
204,
4
] | 3 | [] | [] | 0 | true | Domain | Domain of unknown function DUF7680 | Domain of unknown function DUF7680 | DUF7680 | 1 |
IPR056098 | 56,098 | Acb2/Tad1, hairpin domain | Acb2/Tad1_hairpin | Domain | 1,426 | false | false | This domain, previously known as DUF7681, is found in phage proteins including Anti-CBASS protein 2 (Acb2) and Thoeris anti-defense 1 (Tad1). It folds into an α-helical hairpin that is found either standalone (in Acb2) or in combination with a four-stranded antiparallel β-sheet domain (in Tad1) [ , , ]. Prokaryotic ant... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24729"
] | [
"Acb2_Tad1_hairpin"
] | [
1426
] | 1 | [] | [] | [] | 0 | [
"7uav",
"7uaw",
"7uq2",
"8h2j",
"8h2x",
"8h39",
"8ixz",
"8iy0",
"8iy1",
"8iy2",
"8j8o",
"8kbb",
"8kbc",
"8kbd",
"8kbe",
"8kbf",
"8kbg",
"8kbh",
"8smd",
"9ptq"
] | 20 | [
"PUB00153173",
"PUB00156031",
"PUB00156032",
"PUB00156033"
] | [
"36848932",
"36174646",
"39478223",
"38103556"
] | [
"Ubiquitin-like conjugation by bacterial cGAS enhances anti-phage defence.",
"Viruses inhibit TIR gcADPR signalling to overcome bacterial defence.",
"Single phage proteins sequester signals from TIR and cGAS-like enzymes.",
"Phage anti-CBASS protein simultaneously sequesters cyclic trinucleotides and dinucleo... | [
2023,
2022,
2024,
2024
] | 4 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Viruses",
"metagenomes"
] | [
800,
4,
557,
65
] | 4 | [] | [] | 0 | true | Domain | Acb2/Tad1, hairpin domain | Acb2/Tad1, hairpin domain | Acb2/Tad1_hairpin | 7 |
IPR056099 | 56,099 | Domain of unknown function DUF7682 | DUF7682 | Domain | 198 | false | false | This entry represents a small zinc-binding domain found to the N-terminal of proteins that belong to the ParE toxin superfamily. The exact function of this domain is unknown. The zinc ligands are composed of the Cys and His in the N-terminal CGH motif and the Cys residues in the C-terminal CHXC motif. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24730"
] | [
"DUF7682"
] | [
198
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria"
] | [
198
] | 1 | [] | [] | 0 | true | Domain | Domain of unknown function DUF7682 | Domain of unknown function DUF7682 | DUF7682 | 8 |
IPR056100 | 56,100 | Domain of unknown function DUF7683 | DUF7683 | Domain | 550 | false | false | This family represents uncharacterised proteins found in bacteria. These proteins are related to members of which are described as immunity proteins. They are predicted to adopt similar structure composed of a four-stranded antiparallel β-sheet with α-helices packed on one side of it. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24731"
] | [
"DUF7683"
] | [
550
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"ecological metagenomes"
] | [
543,
7
] | 2 | [] | [] | 0 | true | Domain | Domain of unknown function DUF7683 | Domain of unknown function DUF7683 | DUF7683 | 2 |
IPR056101 | 56,101 | Domain of unknown function DUF7684 | DUF7684 | Domain | 223 | false | false | This entry represents a group of uncharacterised bacterial proteins found in bacteria. They are predicted to adopt a globular α/β structure that has some similarity to MurD C-terminal domain. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24733"
] | [
"DUF7684"
] | [
223
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"bioreactor metagenome"
] | [
220,
2,
1
] | 3 | [] | [] | 0 | true | Domain | Domain of unknown function DUF7684 | Domain of unknown function DUF7684 | DUF7684 | 9 |
IPR056102 | 56,102 | Domain of unknown function DUF7685 | DUF7685 | Domain | 137 | false | false | This domain is found in uncharacterised bacterial proteins. It contains two pairs of conserved cysteine residues and it is predicted to adopt a fold typical for treble clef zinc fingers. It has a detectable similarity to the N-terminal zinc finger domain of the bacterial AAA+ disaggregase ClpG, which confers extreme he... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24734"
] | [
"DUF7685"
] | [
137
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"ecological metagenomes"
] | [
135,
2
] | 2 | [] | [] | 0 | true | Domain | Domain of unknown function DUF7685 | Domain of unknown function DUF7685 | DUF7685 | 2 |
IPR056103 | 56,103 | Domain of unknown function DUF7686 | DUF7686 | Domain | 163 | false | false | This domain is found in uncharacterised bacterial proteins. It is usually found next to . It is predicted to adopt α/β structure consisting of a four-stranded β-sheet curved around an α-helix. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24735"
] | [
"DUF7686"
] | [
163
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"ecological metagenomes"
] | [
155,
8
] | 2 | [] | [] | 0 | true | Domain | Domain of unknown function DUF7686 | Domain of unknown function DUF7686 | DUF7686 | 6 |
IPR056104 | 56,104 | Domain of unknown function DUF7687 | DUF7687 | Domain | 83 | false | false | This entry represents a domain found in uncharacterised bacterial proteins. It shares detectable similarity to a number of type II restriction endonucleases such as DpnII and Ecl18kI and it is predicted to adopt similar structure. It is likely to possess endonuclease activity given the conservation of putative function... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24736"
] | [
"DUF7687"
] | [
83
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Thermoproteota archaeon",
"hydrothermal vent metagenome"
] | [
81,
1,
1
] | 3 | [] | [] | 0 | true | Domain | Domain of unknown function DUF7687 | Domain of unknown function DUF7687 | DUF7687 | 3 |
IPR056105 | 56,105 | Domain of unknown function DUF7688 | DUF7688 | Domain | 365 | false | false | This entry represents a small family of uncharacterised protein found in bacteria. They are predicted to adopt α+β structure defined as β(2)α(2)β(2) structural elements in which the β-strands form an antiparallel β-sheet. The function of these proteins is unknown. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24737"
] | [
"DUF7688"
] | [
365
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Biomphalaria pfeifferi",
"Pseudomonadati",
"Siphoviridae sp. ctBLh2",
"metagenomes"
] | [
1,
359,
1,
4
] | 4 | [] | [] | 0 | true | Domain | Domain of unknown function DUF7688 | Domain of unknown function DUF7688 | DUF7688 | 9 |
IPR056106 | 56,106 | Domain of unknown function DUF7689 | DUF7689 | Domain | 306 | false | false | This entry represents a group of uncharacterised proteins. They are predicted to adopt a fold typical for cysteine proteinases and topology similar to that of NlpC/P60 family proteins. These proteins are likely enzymes as they have similar active site architecture. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24738"
] | [
"DUF7689"
] | [
306
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Methanomicrobia",
"ecological metagenomes"
] | [
239,
61,
2,
4
] | 4 | [] | [] | 0 | true | Domain | Domain of unknown function DUF7689 | Domain of unknown function DUF7689 | DUF7689 | 5 |
IPR056107 | 56,107 | Domain of unknown function DUF7690 | DUF7690 | Domain | 60 | false | false | This entry represents a domain found in uncharacterised bacterial proteins. It is found N-terminal to . This domain is predicted to adopt a globular structure composed of four α-helices. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24739"
] | [
"DUF7690"
] | [
60
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"hydrothermal vent metagenome"
] | [
59,
1
] | 2 | [] | [] | 0 | true | Domain | Domain of unknown function DUF7690 | Domain of unknown function DUF7690 | DUF7690 | 2 |
IPR056108 | 56,108 | Domain of unknown function DUF7691 | DUF7691 | Domain | 543 | false | false | This entry represents a group of uncharacterised bacterial proteins. They share detectable similarity to proteins members of whose function is unknown. Their predicted structures resemble the structure of DNA mimic protein DMP12 but elaborated with additional α-helices. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24740"
] | [
"DUF7691"
] | [
543
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Cylindrotheca closterium"
] | [
542,
1
] | 2 | [] | [] | 0 | true | Domain | Domain of unknown function DUF7691 | Domain of unknown function DUF7691 | DUF7691 | 8 |
IPR056109 | 56,109 | Domain of unknown function DUF7692 | DUF7692 | Domain | 159 | false | false | This domain is found in a group of proteins from Halobacteria. It is predicted to adopt a structure that is reminiscent of ribbon-helix-helix fold. Members of this entry are likely to form dimers. They have a stretch of positively charged residues at the N terminus. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24743"
] | [
"DUF7692"
] | [
159
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Betapleolipovirus",
"Halobacteriales"
] | [
2,
157
] | 2 | [] | [] | 0 | true | Domain | Domain of unknown function DUF7692 | Domain of unknown function DUF7692 | DUF7692 | 7 |
IPR056110 | 56,110 | Domain of unknown function DUF7693 | DUF7693 | Domain | 585 | false | false | This entry represents a group of uncharacterised bacterial proteins. They are predicted to adopt a globular structure consisting of a five-stranded antiparallel β-sheet and helices packed on one side of it. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24745"
] | [
"DUF7693"
] | [
585
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Rhabditidae",
"marine sediment metagenome"
] | [
581,
2,
2
] | 3 | [] | [] | 0 | true | Domain | Domain of unknown function DUF7693 | Domain of unknown function DUF7693 | DUF7693 | 3 |
IPR056111 | 56,111 | Domain of unknown function DUF7694 | DUF7694 | Domain | 278 | false | false | This entry represents a domain found in uncharacterised bacterial proteins. They are predicted to adopt a globular structure consisting of an antiparallel β-sheet and α-helix packed on it. Most members contain a highly conserved HhW sequence motif where h is hydrophobic residue. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24746"
] | [
"DUF7694"
] | [
278
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Fusarium",
"Halococcus hamelinensis 100A6",
"Viruses",
"unclassified sequences"
] | [
219,
2,
1,
31,
25
] | 5 | [] | [] | 0 | true | Domain | Domain of unknown function DUF7694 | Domain of unknown function DUF7694 | DUF7694 | 4 |
IPR056112 | 56,112 | Domain of unknown function DUF7695 | DUF7695 | Domain | 188 | false | false | This domain is found in uncharacterised bacterial proteins. It contains a pair of conserved cysteines and it is predicted to adopt a fold which is typical for zinc-ribbon domains. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24749"
] | [
"DUF7695"
] | [
188
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Candidatus Iainarchaeum sp.",
"Viruses",
"metagenomes"
] | [
138,
1,
22,
27
] | 4 | [] | [] | 0 | true | Domain | Domain of unknown function DUF7695 | Domain of unknown function DUF7695 | DUF7695 | 9 |
IPR056114 | 56,114 | Protein of unknown function DUF7697 | DUF7697 | Family | 354 | false | false | This entry represents a small family of uncharacterised proteins. Although apparently having a bacterial origin these proteins appear in genomic contexts suggesting they are part of an integrated phage genome. Structurally these proteins are composed of a β-hairpin followed by a pair of α-helices. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24752"
] | [
"DUF7697"
] | [
354
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Alphaproteobacteria",
"mine drainage metagenome"
] | [
353,
1
] | 2 | [] | [] | 0 | true | Family | Protein of unknown function DUF7697 | Protein of unknown function DUF7697 | DUF7697 | 3 |
IPR056115 | 56,115 | Domain of unknown function DUF7698 | DUF7698 | Domain | 86 | false | false | This entry represents a domain from uncharacterised proteins found mainly in Firmicutes. It is predicted to adopt a globular structure consisting of a curved β-sheet and α-helices packed on one side of it. It contains a number of conserved aromatic hydrophobic residues, some of which are predicted to be solvent-exposed... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24753"
] | [
"DUF7698"
] | [
86
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"bioreactor metagenome",
"unclassified Caudoviricetes"
] | [
74,
1,
11
] | 3 | [] | [] | 0 | true | Domain | Domain of unknown function DUF7698 | Domain of unknown function DUF7698 | DUF7698 | 1 |
IPR056116 | 56,116 | Domain of unknown function DUF7699 | DUF7699 | Domain | 1,090 | false | false | This domain of unknown function is found in Zinc finger CCCH domain-containing protein 62 from Oryza sativa (C3H62) and similar proteins from plants. Members of this family also show a SAP domain (Pfam:PF02037). This domain is predicted to adopt a mainly beta configuration. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24766"
] | [
"DUF7699"
] | [
1090
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Pseudomonadati",
"Viridiplantae"
] | [
16,
1074
] | 2 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
5,
4,
7
] | 3 | true | Domain | Domain of unknown function DUF7699 | Domain of unknown function DUF7699 | DUF7699 | 8 |
IPR056117 | 56,117 | Domain of unknown function DUF7700 | DUF7700 | Domain | 97 | false | false | This domain is usually found in tandem in uncharacterised bacterial proteins. It is predicted to adopt a globular structure consisting of a curved anti-parallel β-sheet and α-helices packed on one side of it. It contains highly conserved aspartate and histidine residues that may constitute a metal binding site. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24777"
] | [
"DUF7700"
] | [
97
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Metazoa",
"metagenomes"
] | [
44,
17,
36
] | 3 | [] | [] | 0 | true | Domain | Domain of unknown function DUF7700 | Domain of unknown function DUF7700 | DUF7700 | 4 |
IPR056118 | 56,118 | Domain of unknown function DUF7701 | DUF7701 | Domain | 98 | false | false | This domain is found in uncharacterised proteins mainly from bacteria. It is predicted to adopt an α-helical structure with a highly conserved DVHDxWxxW sequence motif which may constitute a ligand binding site. This domain is likely to form a homodimer. Investigation of STRING networks suggests this protein may functi... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24792"
] | [
"DUF7701"
] | [
98
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacillati",
"Caudoviricetes",
"ecological metagenomes"
] | [
81,
15,
2
] | 3 | [] | [] | 0 | true | Domain | Domain of unknown function DUF7701 | Domain of unknown function DUF7701 | DUF7701 | 4 |
IPR056119 | 56,119 | Domain of unknown function DUF7702 | DUF7702 | Domain | 3,473 | false | false | This entry represents a domain found in uncharacterised proteins mainly from fungi. It has a detectable similarity to domains members of Lipid-translocating exporter superfamily and are predicted to adopt similar structure. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24800"
] | [
"DUF7702"
] | [
3473
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
3473
] | 1 | [] | [] | 0 | true | Domain | Domain of unknown function DUF7702 | Domain of unknown function DUF7702 | DUF7702 | 4 |
IPR056120 | 56,120 | Domain of unknown function DUF7703 | DUF7703 | Domain | 4,419 | false | false | This domain is found in a group of uncharacterised proteins mainly from fungi. It is predicted to contain seven transmembrane helices. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24802"
] | [
"DUF7703"
] | [
4419
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
4419
] | 1 | [] | [] | 0 | true | Domain | Domain of unknown function DUF7703 | Domain of unknown function DUF7703 | DUF7703 | 9 |
IPR056121 | 56,121 | Domain of unknown function DUF7704 | DUF7704 | Domain | 3,257 | false | false | This domain is found in a group of uncharacterised eukaryotic proteins. It has a detectable similarity to Tumor protein p53-inducible protein 11 (TP53I11) and it is predicted to adopt similar structure. | [] | [] | [] | 0 | [
"PFAM",
"PANTHER"
] | [
"PF24803",
"PTHR37019"
] | [
"DUF7704",
""
] | [
3220,
3159
] | 2 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
3257
] | 1 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)"
] | [
3
] | 1 | true | Domain | Domain of unknown function DUF7704 | Domain of unknown function DUF7704 | DUF7704 | 4 |
IPR056122 | 56,122 | Domain of unknown function DUF7705 | DUF7705 | Domain | 1,634 | false | false | This domain is found in a group of uncharacterised plant proteins. It has remote similarity to some glucanases and it is predicted to adopt similar β-sandwich structure but elaborated with additional strands. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24804"
] | [
"DUF7705"
] | [
1634
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1634
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
15,
6,
8
] | 3 | true | Domain | Domain of unknown function DUF7705 | Domain of unknown function DUF7705 | DUF7705 | 9 |
IPR056123 | 56,123 | Protein of unknown function DUF7706 | DUF7706 | Family | 404 | false | false | This entry represents an uncharacterised family of bacterial proteins. Structure prediction ( , AF3 iPTM=0.93) suggests that these proteins form dimers. The monomer is composed of three α helices. STRING provides some weak evidence that these proteins may be immunity proteins or perhaps part of a plasmid addiction syst... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24806"
] | [
"DUF7706"
] | [
404
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Biomphalaria pfeifferi",
"Kisquattuordecimvirus",
"uncultured prokaryote"
] | [
399,
1,
2,
2
] | 4 | [] | [] | 0 | true | Family | Protein of unknown function DUF7706 | Protein of unknown function DUF7706 | DUF7706 | 8 |
IPR056124 | 56,124 | Domain of unknown function DUF7707 | DUF7707 | Domain | 2,317 | false | false | This domain is found in uncharacterised fungal proteins. It contains a set of highly conserved cysteine residues that are predicted to form disulfide bonds. It is likely that proteins containing this domain are secreted. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24808"
] | [
"DUF7707"
] | [
2317
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Streptomyces polychromogenes"
] | [
2316,
1
] | 2 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)"
] | [
3
] | 1 | true | Domain | Domain of unknown function DUF7707 | Domain of unknown function DUF7707 | DUF7707 | 4 |
IPR056125 | 56,125 | Domain of unknown function DUF7708 | DUF7708 | Domain | 6,190 | false | false | This domain is found N-terminal in uncharacterised fungal proteins. It shares detectable similarity to the N-terminal domain of NACHT proteins and it is predicted to adopt similar structure. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24809"
] | [
"DUF7708"
] | [
6190
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
6190
] | 1 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)"
] | [
6
] | 1 | true | Domain | Domain of unknown function DUF7708 | Domain of unknown function DUF7708 | DUF7708 | 6 |
IPR056126 | 56,126 | Domain of unknown function DUF7709 | DUF7709 | Domain | 336 | false | false | This domain is found in uncharacterised proteins. It is predicted to adopt a globular structure consisting of array of helices followed by a beta-hairpin. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24813"
] | [
"DUF7709"
] | [
336
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Pseudomonadati"
] | [
150,
186
] | 2 | [] | [] | 0 | true | Domain | Domain of unknown function DUF7709 | Domain of unknown function DUF7709 | DUF7709 | 1 |
IPR056127 | 56,127 | Domain of unknown function DUF7710 | DUF7710 | Domain | 206 | false | false | This entry represents a small family of uncharacterised bacterial proteins. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24819"
] | [
"DUF7710"
] | [
206
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria"
] | [
206
] | 1 | [] | [] | 0 | true | Domain | Domain of unknown function DUF7710 | Domain of unknown function DUF7710 | DUF7710 | 4 |
IPR056128 | 56,128 | Domain of unknown function DUF7711 | DUF7711 | Domain | 144 | false | false | This entry represents a small family of uncharacterised Actinomycete proteins. These proteins may form homodimers (AlphaFold3 A6WE73 ipTM = 0.79). The dimerisation is mediated by a C-terminal α-helical subdomain. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24821"
] | [
"DUF7711"
] | [
144
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Actinomycetes"
] | [
144
] | 1 | [] | [] | 0 | true | Domain | Domain of unknown function DUF7711 | Domain of unknown function DUF7711 | DUF7711 | 9 |
IPR056129 | 56,129 | Protein of unknown function DUF7712 | DUF7712 | Family | 16 | false | false | This entry represents a small family of uncharacterised bacterial proteins. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24822"
] | [
"DUF7712"
] | [
16
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacillati"
] | [
16
] | 1 | [] | [] | 0 | true | Family | Protein of unknown function DUF7712 | Protein of unknown function DUF7712 | DUF7712 | 7 |
IPR056130 | 56,130 | Domain of unknown function DUF7713 | DUF7713 | Domain | 194 | false | false | This entry represents a protein domain that forms an intimate self-self dimer. The domain is found at the C-terminal of proteins that often have a domain. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24828"
] | [
"DUF7713"
] | [
194
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"ecological metagenomes"
] | [
184,
10
] | 2 | [] | [] | 0 | true | Domain | Domain of unknown function DUF7713 | Domain of unknown function DUF7713 | DUF7713 | 7 |
IPR056131 | 56,131 | Protein of unknown function DUF7714 | DUF7714 | Family | 228 | false | false | This entry represents a group of uncharacterised prokaryotic proteins. They are likely to contain two domains that create a compact, elongated structure. Towards the C-terminal, these proteins have two highly conserved pairs of cysteines which are likely to be involved in metal coordination. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24830"
] | [
"DUF7714"
] | [
228
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Methanobacteriati",
"ecological metagenomes"
] | [
81,
134,
13
] | 3 | [] | [] | 0 | true | Family | Protein of unknown function DUF7714 | Protein of unknown function DUF7714 | DUF7714 | 6 |
IPR056132 | 56,132 | Domain of unknown function DUF7715 | DUF7715 | Domain | 265 | false | false | This entry represents a family of uncharacterised actinobacterial proteins that are related to . | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24831"
] | [
"DUF7715"
] | [
265
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria"
] | [
265
] | 1 | [] | [] | 0 | true | Domain | Domain of unknown function DUF7715 | Domain of unknown function DUF7715 | DUF7715 | 7 |
IPR056133 | 56,133 | Domain of unknown function DUF7716 | DUF7716 | Domain | 753 | false | false | This domain is found in uncharacterised bacterial proteins either standalone or in combination with other domains. It is predicted to adopt a globular structure consisting of an antiparallel three-stranded β-sheet and α-helices packed on one side of it. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24832"
] | [
"DUF7716"
] | [
753
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Knufia peltigerae",
"Natrinema altunense"
] | [
750,
1,
2
] | 3 | [] | [] | 0 | true | Domain | Domain of unknown function DUF7716 | Domain of unknown function DUF7716 | DUF7716 | 9 |
IPR056136 | 56,136 | Domain of unknown function DUF7719 | DUF7719 | Domain | 1,400 | false | false | This domain is found in uncharacterised proteins mainly from fungi. It is predicted to fold into three transmembrane helices. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24841"
] | [
"DUF7719"
] | [
1400
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1400
] | 1 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)"
] | [
1
] | 1 | true | Domain | Domain of unknown function DUF7719 | Domain of unknown function DUF7719 | DUF7719 | 4 |
IPR056137 | 56,137 | Domain of unknown function DUF7720 | DUF7720 | Domain | 47 | false | false | This entry represents a small domain found in streptococcal phage proteins. Structurally the domain is composed of a three stranded β-sheet followed by an α-helix. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24843"
] | [
"DUF7720"
] | [
47
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Streptococcus",
"Viruses"
] | [
40,
7
] | 2 | [] | [] | 0 | true | Domain | Domain of unknown function DUF7720 | Domain of unknown function DUF7720 | DUF7720 | 3 |
IPR056138 | 56,138 | Domain of unknown function DUF7721 | DUF7721 | Domain | 1,474 | false | false | This domain is found in uncharacterised proteins from fungi. It is predicted to adopt globular structure consisting of array of helices. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24845"
] | [
"DUF7721"
] | [
1474
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1474
] | 1 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)"
] | [
1
] | 1 | true | Domain | Domain of unknown function DUF7721 | Domain of unknown function DUF7721 | DUF7721 | 2 |
IPR056139 | 56,139 | Domain of unknown function DUF7722 | DUF7722 | Domain | 1,819 | false | false | This domain is found in uncharacterised plant proteins. It is predicted to contain helix-extended loop-helix (HeH) structure and has similarity to domains containing this motif. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24847"
] | [
"DUF7722"
] | [
1819
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1819
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
20,
8,
19
] | 3 | true | Domain | Domain of unknown function DUF7722 | Domain of unknown function DUF7722 | DUF7722 | 8 |
IPR056140 | 56,140 | Domain of unknown function DUF7723 | DUF7723 | Domain | 78 | false | false | This small family of uncharacterised bacterial proteins are often found adjacent to proteins from . Structure prediction shows that these proteins are very likely to form a complex. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24848"
] | [
"DUF7723"
] | [
78
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria"
] | [
78
] | 1 | [] | [] | 0 | true | Domain | Domain of unknown function DUF7723 | Domain of unknown function DUF7723 | DUF7723 | 4 |
IPR056141 | 56,141 | Domain of unknown function DUF7724 | DUF7724 | Domain | 102 | false | false | This entry represents a family of bacterial proteins composed of an all β strand domain composed of 7 β-strands. Structure prediction suggests that these proteins will form a complex with proteins from . | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24849"
] | [
"DUF7724"
] | [
102
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria"
] | [
102
] | 1 | [] | [] | 0 | true | Domain | Domain of unknown function DUF7724 | Domain of unknown function DUF7724 | DUF7724 | 8 |
IPR056142 | 56,142 | Domain of unknown function DUF7725 | DUF7725 | Domain | 1,349 | false | false | This domain is found in uncharacterised plan proteins. It has detectable similarity to winged helix HTH domains and it is predicted to adopt similar structure. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24851"
] | [
"DUF7725"
] | [
1349
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Viridiplantae"
] | [
1349
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
4,
4,
27
] | 3 | true | Domain | Domain of unknown function DUF7725 | Domain of unknown function DUF7725 | DUF7725 | 9 |
IPR056143 | 56,143 | Domain of unknown function DUF7726 | DUF7726 | Domain | 1,319 | false | false | This domain is found in uncharacterised fungal proteins. It has detectable similarity to HTH domains and it is predicted to adopt similar structure. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24852"
] | [
"DUF7726"
] | [
1319
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota"
] | [
3,
1316
] | 2 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)"
] | [
1
] | 1 | true | Domain | Domain of unknown function DUF7726 | Domain of unknown function DUF7726 | DUF7726 | 7 |
IPR056144 | 56,144 | Domain of unknown function DUF7727 | DUF7727 | Domain | 1,343 | false | false | This domain is found in uncharacterised fungal proteins. It has detectable similarity to proteins members of the Cytochrome b558 subunit alpha family and it is predicted to adopt similar structure composed of four helices. | [] | [] | [] | 0 | [
"PFAM",
"PANTHER"
] | [
"PF24853",
"PTHR40629"
] | [
"DUF7727",
""
] | [
1342,
1219
] | 2 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1343
] | 1 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)"
] | [
1
] | 1 | true | Domain | Domain of unknown function DUF7727 | Domain of unknown function DUF7727 | DUF7727 | 3 |
IPR056145 | 56,145 | Domain of unknown function DUF7728 | DUF7728 | Domain | 955 | false | false | This domain is found in uncharacterised fungal proteins. It is predicted to fold into a β-sandwich. It contains highly conserved cysteine residues that are predicted to form a disulfide bond. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24854"
] | [
"DUF7728"
] | [
955
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"leotiomyceta"
] | [
955
] | 1 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)"
] | [
1
] | 1 | true | Domain | Domain of unknown function DUF7728 | Domain of unknown function DUF7728 | DUF7728 | 9 |
IPR056146 | 56,146 | Domain of unknown function DUF7729 | DUF7729 | Domain | 1,791 | false | false | This domain is found in uncharacterised fungal proteins. It is predicted to adopt a globular structure consisting of array of α-helices. It contains several conserved cysteine residues that are predicted to form disulfide bonds. It is likely that the proteins containing this domain are secreted. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24855"
] | [
"DUF7729"
] | [
1791
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1791
] | 1 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)"
] | [
1
] | 1 | true | Domain | Domain of unknown function DUF7729 | Domain of unknown function DUF7729 | DUF7729 | 7 |
IPR056147 | 56,147 | NqrA, N-terminal barrel-sandwich hybrid domain | NQRA_N | Domain | 4,583 | false | false | This domain is found N-terminal in several bacterial Na(+)-translocating NADH-quinone reductase subunit A (NqrA) proteins. The Na(+)-translocating NADH: ubiquinone oxidoreductase (Na(+)-NQR) generates an electrochemical Na(+) potential driven by aerobic respiration [ ]. This domain has a significant similarity to known... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF05896"
] | [
"NQRA_N"
] | [
4583
] | 1 | [
"EC"
] | [
"7.2.1.1"
] | [
"EC:7.2.1.1"
] | 1 | [
"4u9o",
"4u9q",
"7xk3",
"7xk4",
"7xk5",
"7xk6",
"7xk7",
"8a1t",
"8a1u",
"8a1v",
"8a1w",
"8a1x",
"8a1y",
"8acw",
"8acy",
"8ad0",
"8evu",
"8ew3",
"9lrr",
"9u5g",
"9ud2",
"9ud3",
"9ud4",
"9ud5",
"9ud6",
"9ud8",
"9ud9",
"9uda",
"9udf",
"9udg",
"9uuu"
] | 31 | [
"PUB00011393",
"PUB00155761"
] | [
"10587447",
"25471880"
] | [
"Sequencing and preliminary characterization of the Na+-translocating NADH:ubiquinone oxidoreductase from Vibrio harveyi.",
"Structure of the V. cholerae Na+-pumping NADH:quinone oxidoreductase."
] | [
1999,
2014
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
4497,
9,
77
] | 3 | [] | [] | 0 | true | Domain | NqrA, N-terminal barrel-sandwich hybrid domain | NqrA, N-terminal barrel-sandwich hybrid domain | NQRA_N | 3 |
IPR056148 | 56,148 | NqrA, second alpha/beta domain | NQRA_2nd | Domain | 4,642 | false | false | This domain is found in several bacterial Na(+)-translocating NADH-quinone reductase subunit A (NqrA) proteins. The Na(+)-translocating NADH: ubiquinone oxidoreductase (Na(+)-NQR) generates an electrochemical Na(+) potential driven by aerobic respiration [ ]. This domain has an α/β structure and binds an FMN cofactor [... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24836"
] | [
"NQRA_2nd"
] | [
4642
] | 1 | [
"EC"
] | [
"7.2.1.1"
] | [
"EC:7.2.1.1"
] | 1 | [
"4u9o",
"4u9q",
"7xk3",
"7xk4",
"7xk5",
"7xk6",
"7xk7",
"8a1t",
"8a1u",
"8a1v",
"8a1w",
"8a1x",
"8a1y",
"8acw",
"8acy",
"8ad0",
"8evu",
"8ew3",
"9lrr",
"9u5g",
"9ud2",
"9ud3",
"9ud4",
"9ud5",
"9ud6",
"9ud8",
"9ud9",
"9uda",
"9udf",
"9udg",
"9uuu"
] | 31 | [
"PUB00011393",
"PUB00155761"
] | [
"10587447",
"25471880"
] | [
"Sequencing and preliminary characterization of the Na+-translocating NADH:ubiquinone oxidoreductase from Vibrio harveyi.",
"Structure of the V. cholerae Na+-pumping NADH:quinone oxidoreductase."
] | [
1999,
2014
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
4550,
10,
82
] | 3 | [] | [] | 0 | true | Domain | NqrA, second alpha/beta domain | NqrA, second alpha/beta domain | NQRA_2nd | 5 |
IPR056149 | 56,149 | ATP-dependent RNA helicase PRP5/DDX46/KHDC4, KH domain | PRP5/DDX46/KHDC4_KH | Domain | 8,153 | false | false | This entry represents a likely RNA-binding KH domain found at the C teminus of Pre-mRNA-processing ATP-dependent RNA helicase PRP5 from Saccharomyces cerevisiae, the Probable ATP-dependent RNA helicase DDX46 from human (DDX46) and similar eukaryotic proteins. PRP5 is involved in spliceosome assembly and in nuclear spli... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23469"
] | [
"KH_12"
] | [
8153
] | 1 | [
"EC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"3.6.4.13",
"R-DDI-72163",
"R-DRE-72163",
"R-HSA-72163",
"R-MMU-72163",
"R-RNO-72163",
"R-SPO-72163"
] | [
"EC:3.6.4.13",
"REACTOME:R-DDI-72163",
"REACTOME:R-DRE-72163",
"REACTOME:R-HSA-72163",
"REACTOME:R-MMU-72163",
"REACTOME:R-RNO-72163",
"REACTOME:R-SPO-72163"
] | 7 | [
"6y50",
"6y53",
"6y5q",
"7evo",
"7oqb",
"7oqe",
"7q3l",
"7vpx"
] | 8 | [
"PUB00013034",
"PUB00086864",
"PUB00109287",
"PUB00155986",
"PUB00155987",
"PUB00155988",
"PUB00155989",
"PUB00155990",
"PUB00155991"
] | [
"12234937",
"19641227",
"8969184",
"14610285",
"32494006",
"34349264",
"34822310",
"36797247",
"38196034"
] | [
"Characterization of novel SF3b and 17S U2 snRNP proteins, including a human Prp5p homologue and an SF3b DEAD-box protein.",
"Blom7alpha is a novel heterogeneous nuclear ribonucleoprotein K homology domain protein involved in pre-mRNA splicing that interacts with SNEVPrp19-Pso4.",
"The Saccharomyces cerevisiae ... | [
2002,
2009,
1996,
2003,
2020,
2021,
2022,
2023,
2024
] | 9 | [] | [
"IPR047890"
] | 0 | 1 | 0 | [
"Eukaryota"
] | [
8153
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
16,
1,
10,
9,
7,
3,
2,
8,
7,
1,
2,
14
] | 12 | true | Domain | ATP-dependent RNA helicase PRP5/DDX46/KHDC4, KH domain | ATP-dependent RNA helicase PRP5/DDX46/KHDC4, KH domain | PRP5/DDX46/KHDC4_KH | 1 |
IPR056150 | 56,150 | CDC20/Fizzy, WD40 domain | WD40_CDC20-Fz | Domain | 13,048 | false | false | This entry represents the β-propeller found in the homologues of WD40 protein Cdc20/Fizzy, a protein that associates and phosphorylates anaphase promoting complex/cyclosome (APC/C) at the end of mitosis [ , ]. It is required for full ubiquitin ligase activity of the APC/C and confers substrate specificity upon the comp... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24807"
] | [
"WD40_CDC20-Fz"
] | [
13048
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-CEL-141405",
"R-CEL-141430",
"R-CEL-5689880",
"R-CEL-983168",
"R-DDI-141405",
"R-DDI-141430",
"R-DDI-174048",
"R-DDI-174084",
"R-DDI-174154",
"R-DDI-174178",
"R-DDI-174184",
"R-DDI-176407",
"R-DDI-176408",
"R-DDI-176409",
"R-DDI-179409",
"R-DDI-2467813",
"R-DDI-2559582",
"R-DDI-... | [
"REACTOME:R-CEL-141405",
"REACTOME:R-CEL-141430",
"REACTOME:R-CEL-5689880",
"REACTOME:R-CEL-983168",
"REACTOME:R-DDI-141405",
"REACTOME:R-DDI-141430",
"REACTOME:R-DDI-174048",
"REACTOME:R-DDI-174084",
"REACTOME:R-DDI-174154",
"REACTOME:R-DDI-174178",
"REACTOME:R-DDI-174184",
"REACTOME:R-DDI-17... | 122 | [
"4aez",
"4bh6",
"4gga",
"4ggc",
"4ggd",
"4n14",
"4ui9",
"5a31",
"5g04",
"5khr",
"5khu",
"5l9t",
"5l9u",
"5lcw",
"6f0x",
"6q6g",
"6q6h",
"6tlj",
"8a3t",
"8tar",
"8tau",
"9gaw",
"9i68",
"9i69",
"9i6a",
"9n9r",
"9n9s"
] | 27 | [
"PUB00091489",
"PUB00155914"
] | [
"26083744",
"27030811"
] | [
"Atomic structure of the APC/C and its mechanism of protein ubiquitination.",
"Ubiquitin-specific protease 22 is a deubiquitinase of CCNB1."
] | [
2015,
2015
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
13048
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
34,
3,
5,
5,
6,
10,
2,
17,
6,
3,
5,
24
] | 12 | true | Domain | CDC20/Fizzy, WD40 domain | CDC20/Fizzy, WD40 domain | WD40_CDC20-Fz | 2 |
IPR056151 | 56,151 | DDB1- and CUL4-associated factor 12, beta-propeller domain | Beta-prop_DCAF12 | Domain | 2,357 | false | false | This entry represents the β-propeller domain found in DDB1- and CUL4-associated factor 12 proteins (DCAF12) as well as DCAF12-like proteins 1 and 2 (DCAF12L1 and DCAF12L2) from animals. DCAF proteins have been hypothesised to play important roles during spermatogenesis due to their high level of conservation in mammals... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23760"
] | [
"Beta-prop_DCAF12"
] | [
2357
] | 1 | [] | [] | [] | 0 | [
"8ajm",
"8ajn",
"8ajo",
"8t9a"
] | 4 | [
"PUB00155518",
"PUB00155519",
"PUB00155520"
] | [
"32867693",
"35850260",
"30670470"
] | [
"Expression profiling of WD40 family genes including DDB1- and CUL4- associated factor (DCAF) genes in mice and human suggests important regulatory roles in testicular development and spermatogenesis.",
"DDB1- and CUL4-associated factor 12-like protein 1 (Dcaf12l1) is not essential for male fertility in mice.",
... | [
2020,
2022,
2019
] | 3 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota"
] | [
7,
2350
] | 2 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
4,
1,
5,
3,
9
] | 5 | true | Domain | DDB1- and CUL4-associated factor 12, beta-propeller domain | DDB1- and CUL4-associated factor 12, beta-propeller domain | Beta-prop_DCAF12 | 8 |
IPR056152 | 56,152 | IFT122, second beta-propeller domain | Beta-prop_IFT122_2nd | Domain | 2,732 | false | false | This entry represents the second β-propeller of IFT122, which is a crucial subunit for IFT-A integrity [ ]. Intraflagellar transport protein 122 homolog (IFT122) is one of the core components (together with WDR19/IFT144 and IFT140) of the IFT-A complex which is required for retrograde ciliary transport and entry into c... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23377"
] | [
"Beta-prop_IFT122_2nd"
] | [
2732
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-CEL-5610787",
"R-CEL-5620924",
"R-HSA-5610787",
"R-HSA-5620924",
"R-MMU-5610787",
"R-MMU-5620924",
"R-XTR-5610787"
] | [
"REACTOME:R-CEL-5610787",
"REACTOME:R-CEL-5620924",
"REACTOME:R-HSA-5610787",
"REACTOME:R-HSA-5620924",
"REACTOME:R-MMU-5610787",
"REACTOME:R-MMU-5620924",
"REACTOME:R-XTR-5610787"
] | 7 | [
"8bbe",
"8bbf",
"8bbg",
"8bda",
"8f5o",
"8f5p",
"8fgw",
"8fh3",
"8hmc",
"8hmd",
"8hme",
"8hmf",
"8ruy"
] | 13 | [
"PUB00101516",
"PUB00155528",
"PUB00155529"
] | [
"29220510",
"36462505",
"27932497"
] | [
"Ciliopathy-associated mutations of IFT122 impair ciliary protein trafficking but not ciliogenesis.",
"IFT-A structure reveals carriages for membrane protein transport into cilia.",
"Intraflagellar transport-A complex mediates ciliary entry and retrograde trafficking of ciliary G protein-coupled receptors."
] | [
2018,
2022,
2017
] | 3 | [] | [] | 0 | 0 | null | [
"Colwellia",
"Eukaryota"
] | [
7,
2725
] | 2 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
7,
2,
54,
2,
7
] | 6 | true | Domain | IFT122, second beta-propeller domain | IFT122, second beta-propeller domain | Beta-prop_IFT122_2nd | 6 |
IPR056153 | 56,153 | IFT122/SMU1, beta-propeller domain | IFT122/SMU1_beta-prop | Domain | 21,764 | false | false | This entry represents a β-propeller found at the N-terminal end of IFT122 and at the C-terminal of SMU1. Members of this group are found in eukaryotes and bacteria. Intraflagellar transport protein 122 homolog (IFT122) is one of the core components (together with WDR19/IFT144 and IFT140) of the IFT-A complex which is r... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23381"
] | [
"Beta-prop_IFT122_1st"
] | [
21764
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-72163",
"R-BTA-8951664",
"R-BTA-983168",
"R-CEL-5610787",
"R-CEL-5620924",
"R-DDI-1257604",
"R-DDI-1632852",
"R-DDI-165159",
"R-DDI-166208",
"R-DDI-3371571",
"R-DDI-380972",
"R-DDI-389357",
"R-DDI-5218920",
"R-DDI-5628897",
"R-DDI-6791226",
"R-DDI-6804757",
"R-DDI-8943724",
... | [
"REACTOME:R-BTA-72163",
"REACTOME:R-BTA-8951664",
"REACTOME:R-BTA-983168",
"REACTOME:R-CEL-5610787",
"REACTOME:R-CEL-5620924",
"REACTOME:R-DDI-1257604",
"REACTOME:R-DDI-1632852",
"REACTOME:R-DDI-165159",
"REACTOME:R-DDI-166208",
"REACTOME:R-DDI-3371571",
"REACTOME:R-DDI-380972",
"REACTOME:R-DD... | 73 | [
"2ymu",
"3j2t",
"3jbt",
"3sfz",
"3shf",
"5juy",
"5mzh",
"5o9z",
"5oql",
"5wve",
"5yzv",
"6ahd",
"6q8f",
"6q8i",
"6rxt",
"6rxu",
"6rxv",
"6rxx",
"6rxy",
"6rxz",
"7bie",
"7mq8",
"7mq9",
"7mqa",
"8bbe",
"8bbf",
"8bbg",
"8bda",
"8f5o",
"8f5p",
"8fgw",
"8fh3"... | 41 | [
"PUB00090272",
"PUB00101516",
"PUB00155528",
"PUB00162459"
] | [
"28781166",
"29220510",
"36462505",
"24945353"
] | [
"Cryo-EM Structure of a Pre-catalytic Human Spliceosome Primed for Activation.",
"Ciliopathy-associated mutations of IFT122 impair ciliary protein trafficking but not ciliogenesis.",
"IFT-A structure reveals carriages for membrane protein transport into cilia.",
"Recruitment of RED-SMU1 complex by Influenza A... | [
2017,
2018,
2022,
2014
] | 4 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"ecological metagenomes"
] | [
12,
4435,
17304,
13
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Schizosaccharomyces pombe (stra... | [
19,
1,
13,
5,
57,
11,
1,
6,
25,
2,
22
] | 11 | true | Domain | IFT122/SMU1, beta-propeller domain | IFT122/SMU1, beta-propeller domain | IFT122/SMU1_beta-prop | 7 |
IPR056154 | 56,154 | IFT140, first beta-propeller domain | Beta-prop_IFT140_1st | Domain | 2,940 | false | false | This entry represents the first β-propeller of IFT140. IFT140 is one of the core components (together with WDR19/IFT144 and IFT122) of the IFT-A complex which is required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs), being involved in cilia function and/or assembly [ , ].... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23383"
] | [
"Beta-prop_IFT140_1st"
] | [
2940
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-5610787",
"R-HSA-5620924",
"R-MMU-5610787",
"R-MMU-5620924"
] | [
"REACTOME:R-HSA-5610787",
"REACTOME:R-HSA-5620924",
"REACTOME:R-MMU-5610787",
"REACTOME:R-MMU-5620924"
] | 4 | [
"8bbf",
"8bbg",
"8bda",
"8f5o",
"8f5p",
"8fgw",
"8fh3",
"8hme",
"8hmf",
"8ruy"
] | 10 | [
"PUB00089704",
"PUB00155528"
] | [
"20889716",
"36462505"
] | [
"TULP3 bridges the IFT-A complex and membrane phosphoinositides to promote trafficking of G protein-coupled receptors into primary cilia.",
"IFT-A structure reveals carriages for membrane protein transport into cilia."
] | [
2010,
2022
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"uncultured Poseidoniia archaeon"
] | [
10,
2929,
1
] | 3 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
1,
1,
4,
3,
6,
6,
1,
3,
10
] | 9 | true | Domain | IFT140, first beta-propeller domain | IFT140, first beta-propeller domain | Beta-prop_IFT140_1st | 2 |
IPR056155 | 56,155 | IFT140, second beta-propeller domain | Beta-prop_IFT140_2nd | Domain | 2,092 | false | false | This entry represents the second β-propeller of IFT140. IFT140 is one of the core components (together with WDR19/IFT144 and IFT122) of the IFT-A complex which is required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs), being involved in cilia function and/or assembly [ , ]... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23385"
] | [
"Beta-prop_IFT140_2nd"
] | [
2092
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-5610787",
"R-HSA-5620924",
"R-MMU-5610787",
"R-MMU-5620924"
] | [
"REACTOME:R-HSA-5610787",
"REACTOME:R-HSA-5620924",
"REACTOME:R-MMU-5610787",
"REACTOME:R-MMU-5620924"
] | 4 | [
"8bbf",
"8bbg",
"8bda",
"8f5o",
"8f5p",
"8fgw",
"8fh3",
"8hme",
"8hmf",
"8ruy"
] | 10 | [
"PUB00089704",
"PUB00155528"
] | [
"20889716",
"36462505"
] | [
"TULP3 bridges the IFT-A complex and membrane phosphoinositides to promote trafficking of G protein-coupled receptors into primary cilia.",
"IFT-A structure reveals carriages for membrane protein transport into cilia."
] | [
2010,
2022
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
2092
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
4,
3,
4,
6,
3
] | 6 | true | Domain | IFT140, second beta-propeller domain | IFT140, second beta-propeller domain | Beta-prop_IFT140_2nd | 9 |
IPR056156 | 56,156 | IF140, C-terminal TPR domain | TPR_IF140_C | Domain | 2,104 | false | false | This entry represents the TPR domain found at the C-terminal of IFT140. IFT140 is one of the core components (together with WDR19/IFT144 and IFT122) of the IFT-A complex which is required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs), being involved in cilia function and/o... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24760"
] | [
"TPR_IF140_C"
] | [
2104
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-5610787",
"R-HSA-5620924",
"R-MMU-5610787",
"R-MMU-5620924"
] | [
"REACTOME:R-HSA-5610787",
"REACTOME:R-HSA-5620924",
"REACTOME:R-MMU-5610787",
"REACTOME:R-MMU-5620924"
] | 4 | [
"8bbf",
"8bbg",
"8bda",
"8f5o",
"8f5p",
"8fgw",
"8fh3",
"8hme",
"8hmf",
"8ruy"
] | 10 | [
"PUB00089704",
"PUB00155528"
] | [
"20889716",
"36462505"
] | [
"TULP3 bridges the IFT-A complex and membrane phosphoinositides to promote trafficking of G protein-coupled receptors into primary cilia.",
"IFT-A structure reveals carriages for membrane protein transport into cilia."
] | [
2010,
2022
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
2104
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
4,
3,
4,
6,
2
] | 6 | true | Domain | IF140, C-terminal TPR domain | IF140, C-terminal TPR domain | TPR_IF140_C | 8 |
IPR056157 | 56,157 | IFT80/172/WDR35, TPR domain | TPR_IFT80_172_dom | Domain | 6,092 | false | false | This entry represents the tetratricopeptide-like repeats (TPRs) domain found in proteins comprising the intraflagellar transport (IFT) complexes B2 and A, which are found in nematodes and mammals, including IFT80, IF172, WDR35, DYF2 and other eukaryotic proteins. The IFT complex is required for retrograde ciliary trans... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23387"
] | [
"TPR_IFT80_172"
] | [
6092
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-CEL-5610787",
"R-CEL-5620924",
"R-DME-5610787",
"R-DRE-5610787",
"R-HSA-5610787",
"R-HSA-5620924",
"R-MMU-5610787",
"R-MMU-5620924",
"R-RNO-5610787",
"R-RNO-5620924"
] | [
"REACTOME:R-CEL-5610787",
"REACTOME:R-CEL-5620924",
"REACTOME:R-DME-5610787",
"REACTOME:R-DRE-5610787",
"REACTOME:R-HSA-5610787",
"REACTOME:R-HSA-5620924",
"REACTOME:R-MMU-5610787",
"REACTOME:R-MMU-5620924",
"REACTOME:R-RNO-5610787",
"REACTOME:R-RNO-5620924"
] | 10 | [
"5n4a",
"8bbe",
"8bbg",
"8bd7",
"8bda",
"8f5o",
"8f5p",
"8fgw",
"8fh3",
"8hmc",
"8hmd",
"8ruy"
] | 12 | [
"PUB00090877",
"PUB00155530",
"PUB00155869",
"PUB00155870"
] | [
"28479320",
"29658880",
"36593313",
"33175651"
] | [
"Dynein-Driven Retrograde Intraflagellar Transport Is Triphasic in C. elegans Sensory Cilia.",
"Crystal structure of intraflagellar transport protein 80 reveals a homo-dimer required for ciliogenesis.",
"The molecular structure of IFT-A and IFT-B in anterograde intraflagellar transport trains.",
"Cooperation ... | [
2017,
2018,
2023,
2021
] | 4 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
6092
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
5,
9,
3,
10,
5,
12
] | 6 | true | Domain | IFT80/172/WDR35, TPR domain | IFT80/172/WDR35, TPR domain | TPR_IFT80_172_dom | 2 |
IPR056158 | 56,158 | IFT121, second beta-propeller domain | Beta-prop_IFT121_2nd | Domain | 2,476 | false | false | This entry represents the second β-propeller of IFT121. IFT121 (also known as WDR35) is a component of the IFT complex A (IFT-A), which is required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors that is involved in ciliogenesis and ciliary protein trafficking [ , , ]. This protein ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23390"
] | [
"Beta-prop_WDR35_2nd"
] | [
2476
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-5610787",
"R-HSA-5620924",
"R-MMU-5610787",
"R-MMU-5620924",
"R-RNO-5610787",
"R-RNO-5620924"
] | [
"REACTOME:R-HSA-5610787",
"REACTOME:R-HSA-5620924",
"REACTOME:R-MMU-5610787",
"REACTOME:R-MMU-5620924",
"REACTOME:R-RNO-5610787",
"REACTOME:R-RNO-5620924"
] | 6 | [
"8bbe",
"8bbg",
"8bda",
"8f5o",
"8f5p",
"8fgw",
"8fh3",
"8hmc",
"8hmd",
"8ruy"
] | 10 | [
"PUB00083315",
"PUB00089704",
"PUB00101515",
"PUB00101516",
"PUB00155528",
"PUB00155869",
"PUB00158865"
] | [
"21473986",
"20889716",
"28400947",
"29220510",
"36462505",
"36593313",
"36775821"
] | [
"Human and mouse mutations in WDR35 cause short-rib polydactyly syndromes due to abnormal ciliogenesis.",
"TULP3 bridges the IFT-A complex and membrane phosphoinositides to promote trafficking of G protein-coupled receptors into primary cilia.",
"Mutations in IFT-A satellite core component genes <i>IFT43</i> an... | [
2011,
2010,
2017,
2018,
2022,
2023,
2023
] | 7 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
2476
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
2,
1,
6,
4,
3
] | 6 | true | Domain | IFT121, second beta-propeller domain | IFT121, second beta-propeller domain | Beta-prop_IFT121_2nd | 9 |
IPR056159 | 56,159 | IFT121/TULP4, N-terminal | Beta-prop_IFT121_TULP_N | Domain | 4,096 | false | false | This entry represents a β-propeller domain found at the N-terminal of IFT121 (which corresponds to the first one) and TULP4 proteins. TULP4 may be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex. IFT-A polymerises and interacts with IFT-B, and uses an ar... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24797"
] | [
"Beta-prop_WDR35_TULP_N"
] | [
4096
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-5610787",
"R-HSA-5620924",
"R-HSA-8951664",
"R-MMU-5610787",
"R-MMU-5620924",
"R-MMU-8951664",
"R-RNO-5610787",
"R-RNO-5620924"
] | [
"REACTOME:R-HSA-5610787",
"REACTOME:R-HSA-5620924",
"REACTOME:R-HSA-8951664",
"REACTOME:R-MMU-5610787",
"REACTOME:R-MMU-5620924",
"REACTOME:R-MMU-8951664",
"REACTOME:R-RNO-5610787",
"REACTOME:R-RNO-5620924"
] | 8 | [
"8bbe",
"8bbg",
"8bda",
"8f5o",
"8f5p",
"8fgw",
"8fh3",
"8hmc",
"8hmd",
"8ruy"
] | 10 | [
"PUB00083315",
"PUB00089704",
"PUB00101515",
"PUB00101516",
"PUB00155528",
"PUB00155869",
"PUB00158865"
] | [
"21473986",
"20889716",
"28400947",
"29220510",
"36462505",
"36593313",
"36775821"
] | [
"Human and mouse mutations in WDR35 cause short-rib polydactyly syndromes due to abnormal ciliogenesis.",
"TULP3 bridges the IFT-A complex and membrane phosphoinositides to promote trafficking of G protein-coupled receptors into primary cilia.",
"Mutations in IFT-A satellite core component genes <i>IFT43</i> an... | [
2011,
2010,
2017,
2018,
2022,
2023,
2023
] | 7 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"mine drainage metagenome"
] | [
4095,
1
] | 2 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
7,
5,
5,
7,
5
] | 6 | true | Domain | IFT121/TULP4, N-terminal | IFT121/TULP4, N-terminal | Beta-prop_IFT121_TULP_N | 4 |
IPR056160 | 56,160 | Leucine-rich repeat and WD repeat-containing protein 1, WD domain | WD_LRWD1 | Domain | 1,381 | false | false | This entry represents the WD (β-propeller) domain found at the C-terminal of Leucine-rich repeat and WD repeat-containing protein 1 (LRWD1) from animals and related sequences. This domain is required for chromatin association of LRWD1 and for its binding to ORC [ ]. LRWD1 (also known as CENP-33 and ORCA) is required fo... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23215"
] | [
"WD_LRWD1"
] | [
1381
] | 1 | [] | [] | [] | 0 | [
"8siu",
"8siy"
] | 2 | [
"PUB00155714",
"PUB00155715",
"PUB00155716"
] | [
"20932478",
"22427655",
"22645314"
] | [
"A WD-repeat protein stabilizes ORC binding to chromatin.",
"Leucine-rich repeat and WD repeat-containing protein 1 is recruited to pericentric heterochromatin by trimethylated lysine 9 of histone H3 and maintains heterochromatin silencing.",
"Dynamic association of ORCA with prereplicative complex components r... | [
2010,
2012,
2012
] | 3 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1381
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
4,
4,
2,
4
] | 4 | true | Domain | Leucine-rich repeat and WD repeat-containing protein 1, WD domain | Leucine-rich repeat and WD repeat-containing protein 1, WD domain | WD_LRWD1 | 8 |
IPR056161 | 56,161 | MABP1/WDR62, first WD40 domain | WD40_MABP1-WDR62_1st | Domain | 2,450 | false | false | This entry represents the first WD40 domain of MABP1 and WDR62. MABP1 (Mitogen-activated protein kinase-binding protein 1) is a negative regulator of NOD2 function, leading to the down-regulation of NOD2-induced processes such as activation of NF-kappa-B signalling, IL8 secretion and antibacterial response [ ]. WDR62 i... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24780"
] | [
"WD40_MABP1-WDR62_1st"
] | [
2450
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00073161",
"PUB00073163",
"PUB00076882",
"PUB00155315",
"PUB00155369",
"PUB00155370"
] | [
"20729831",
"20890278",
"26297806",
"22700971",
"34137789",
"34137788"
] | [
"Whole-exome sequencing identifies recessive WDR62 mutations in severe brain malformations.",
"Mutations in WDR62, encoding a centrosome-associated protein, cause microcephaly with simplified gyri and abnormal cortical architecture.",
"Centriolar satellites assemble centrosomal microcephaly proteins to recruit ... | [
2010,
2010,
2015,
2012,
2021,
2021
] | 6 | [] | [] | 0 | 0 | null | [
"Eumetazoa"
] | [
2450
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
16,
13,
6,
8
] | 4 | true | Domain | MABP1/WDR62, first WD40 domain | MABP1/WDR62, first WD40 domain | WD40_MABP1-WDR62_1st | 4 |
IPR056162 | 56,162 | MABP1/WDR62, second WD40 domain | WD40_MABP1-WDR62_2nd | Domain | 3,550 | false | false | This entry represents the second WD40 domain of MABP1 and WDR62. MABP1 (Mitogen-activated protein kinase-binding protein 1) is a negative regulator of NOD2 function, leading to the down-regulation of NOD2-induced processes such as activation of NF-kappa-B signalling, IL8 secretion and antibacterial response [ ]. WDR62 ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24782"
] | [
"WD40_MABP1-WDR62_2nd"
] | [
3550
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00073161",
"PUB00073163",
"PUB00076882",
"PUB00155315",
"PUB00155369"
] | [
"20729831",
"20890278",
"26297806",
"22700971",
"34137789"
] | [
"Whole-exome sequencing identifies recessive WDR62 mutations in severe brain malformations.",
"Mutations in WDR62, encoding a centrosome-associated protein, cause microcephaly with simplified gyri and abnormal cortical architecture.",
"Centriolar satellites assemble centrosomal microcephaly proteins to recruit ... | [
2010,
2010,
2015,
2012,
2021
] | 5 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
3550
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
16,
8,
10,
7,
9
] | 5 | true | Domain | MABP1/WDR62, second WD40 domain | MABP1/WDR62, second WD40 domain | WD40_MABP1-WDR62_2nd | 1 |
IPR056163 | 56,163 | Transcriptional regulator TbsP-like, C-terminal domain | TbsP_C | Domain | 541 | false | false | This domain is found at the C terminus of the putative transcriptional regulator TbsP from Haloferax volcanii (Halobacterium volcanii) ( , also known as HVO_2861) and similar sequences predominantly found in Halobacteria. TbsP is required for adhesion to abiotic surfaces (i.e., biofilm formation) and maintains wild-typ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23336"
] | [
"HTH_TbsP_C"
] | [
541
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00153356"
] | [
"38204420"
] | [
"TbsP and TrmB jointly regulate gapII to influence cell development phenotypes in the archaeon Haloferax volcanii."
] | [
2024
] | 1 | [] | [] | 0 | 0 | null | [
"Methanobacteriota",
"Stieleria maiorica",
"uncultured prokaryote 2E01B"
] | [
539,
1,
1
] | 3 | [] | [] | 0 | true | Domain | Transcriptional regulator TbsP-like, C-terminal domain | Transcriptional regulator TbsP-like, C-terminal domain | TbsP_C | 3 |
IPR056164 | 56,164 | ELP1, first N-terminal beta-propeller | Beta-prop_ELP1_1st | Domain | 4,877 | false | false | This entry represents the first out of two N-terminal β-propeller domains, found in Elongator complex protein 1 (ELP1) from eukaryotes. Elongator is a conserved protein complex implicated in multiple processes including regulation of transcription, alpha-tubulin acetylation, and tRNA modification. Mutations in the ELP1... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF04762"
] | [
"Beta-prop_ELP1_1st"
] | [
4877
] | 1 | [
"REACTOME"
] | [
"R-HSA-3214847"
] | [
"REACTOME:R-HSA-3214847"
] | 1 | [
"6qk7",
"8asv",
"8asw",
"8avg",
"8ptx",
"8pty",
"8ptz",
"8pu0"
] | 8 | [
"PUB00016033",
"PUB00074322",
"PUB00155480"
] | [
"9751059",
"11818576",
"29332244"
] | [
"IKAP is a scaffold protein of the IkappaB kinase complex.",
"Human Elongator facilitates RNA polymerase II transcription through chromatin.",
"Structural insights into the function of Elongator."
] | [
1998,
2002,
2018
] | 3 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota"
] | [
6,
4871
] | 2 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
5,
1,
6,
5,
24,
1,
1,
4,
4,
1,
1,
5
] | 12 | true | Domain | ELP1, first N-terminal beta-propeller | ELP1, first N-terminal beta-propeller | Beta-prop_ELP1_1st | 8 |
IPR056165 | 56,165 | ELP1, N-terminal second beta-propeller | Beta-prop_ELP1_2nd | Domain | 4,730 | false | false | This entry represents second out of two N-terminal β-propeller domains, found in Elongator complex protein 1 (ELP1) from eukaryotes. Elongator is a conserved protein complex implicated in multiple processes including regulation of transcription, alpha-tubulin acetylation, and tRNA modification. Mutations in the ELP1 ge... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23797"
] | [
"Beta-prop_ELP1_2nd"
] | [
4730
] | 1 | [
"REACTOME"
] | [
"R-HSA-3214847"
] | [
"REACTOME:R-HSA-3214847"
] | 1 | [
"6qk7",
"8asv",
"8asw",
"8avg",
"8ptx",
"8pty",
"8ptz",
"8pu0"
] | 8 | [
"PUB00016033",
"PUB00074322",
"PUB00155480"
] | [
"9751059",
"11818576",
"29332244"
] | [
"IKAP is a scaffold protein of the IkappaB kinase complex.",
"Human Elongator facilitates RNA polymerase II transcription through chromatin.",
"Structural insights into the function of Elongator."
] | [
1998,
2002,
2018
] | 3 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
4730
] | 1 | [
"Arabidopsis thaliana",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"... | [
5,
6,
5,
21,
1,
1,
4,
4,
1,
1,
5
] | 11 | true | Domain | ELP1, N-terminal second beta-propeller | ELP1, N-terminal second beta-propeller | Beta-prop_ELP1_2nd | 5 |
IPR056166 | 56,166 | ELP1, TPR domain | TPR_ELP1 | Domain | 4,418 | false | false | This entry represents the TPR domain found within the C-terminal dimerisation domain of Elongator complex protein 1 (ELP1), from eukaryotes. Elongator is a conserved protein complex implicated in multiple processes including regulation of transcription, alpha-tubulin acetylation and tRNA modification. Mutations in the ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23878"
] | [
"TPR_ELP1"
] | [
4418
] | 1 | [
"REACTOME"
] | [
"R-HSA-3214847"
] | [
"REACTOME:R-HSA-3214847"
] | 1 | [
"5cqr",
"5cqs",
"6qk7",
"8asv",
"8asw",
"8avg",
"8ptx",
"8pty",
"8ptz",
"8pu0"
] | 10 | [
"PUB00016033",
"PUB00074322",
"PUB00155480",
"PUB00155481",
"PUB00155482"
] | [
"9751059",
"11818576",
"29332244",
"26261306",
"23510783"
] | [
"IKAP is a scaffold protein of the IkappaB kinase complex.",
"Human Elongator facilitates RNA polymerase II transcription through chromatin.",
"Structural insights into the function of Elongator.",
"Dimerization of elongator protein 1 is essential for Elongator complex assembly.",
"Structural insights into ... | [
1998,
2002,
2018,
2015,
2013
] | 5 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Streptomyces javensis"
] | [
4417,
1
] | 2 | [
"Arabidopsis thaliana",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"... | [
5,
4,
5,
20,
1,
1,
4,
4,
1,
1,
6
] | 11 | true | Domain | ELP1, TPR domain | ELP1, TPR domain | TPR_ELP1 | 7 |
IPR056167 | 56,167 | ELP1, alpha-solenoid | A-sol_ELP1 | Domain | 4,930 | false | false | This entry represents the α-solenoid domain found within the C-terminal dimerisation domain of Elongator complex protein 1 (ELP1) from eukaryotes. Residues within the α-14-helix are highly conserved from yeast to human and act as a kink to maintain the TPR-like domain and α-solenoid domain at nearly a 90-degree angle. ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23925"
] | [
"A-sol_ELP1"
] | [
4930
] | 1 | [
"REACTOME"
] | [
"R-HSA-3214847"
] | [
"REACTOME:R-HSA-3214847"
] | 1 | [
"5cqr",
"5cqs",
"6qk7",
"8asv",
"8asw",
"8avg",
"8ptx",
"8pty",
"8ptz",
"8pu0"
] | 10 | [
"PUB00016033",
"PUB00074322",
"PUB00155480",
"PUB00155481",
"PUB00155482"
] | [
"9751059",
"11818576",
"29332244",
"26261306",
"23510783"
] | [
"IKAP is a scaffold protein of the IkappaB kinase complex.",
"Human Elongator facilitates RNA polymerase II transcription through chromatin.",
"Structural insights into the function of Elongator.",
"Dimerization of elongator protein 1 is essential for Elongator complex assembly.",
"Structural insights into ... | [
1998,
2002,
2018,
2015,
2013
] | 5 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
4930
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
5,
1,
6,
5,
22,
1,
1,
4,
4,
1,
1,
5
] | 12 | true | Domain | ELP1, alpha-solenoid | ELP1, alpha-solenoid | A-sol_ELP1 | 3 |
IPR056169 | 56,169 | ELP1, three-helical bundle | HB_ELP1 | Domain | 4,310 | false | false | This entry represents the helical bundle domain found within the C-terminal dimerisation domain of Elongator complex protein 1 (ELP1), from eukaryotes. Elongator is a conserved protein complex implicated in multiple processes including regulation of transcription, alpha-tubulin acetylation and tRNA modification. Mutati... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23936"
] | [
"HB_ELP1"
] | [
4310
] | 1 | [
"REACTOME"
] | [
"R-HSA-3214847"
] | [
"REACTOME:R-HSA-3214847"
] | 1 | [
"5cqr",
"5cqs",
"6qk7",
"8asv",
"8asw",
"8avg",
"8ptx",
"8pty",
"8ptz",
"8pu0"
] | 10 | [
"PUB00016033",
"PUB00074322",
"PUB00155480",
"PUB00155481",
"PUB00155482"
] | [
"9751059",
"11818576",
"29332244",
"26261306",
"23510783"
] | [
"IKAP is a scaffold protein of the IkappaB kinase complex.",
"Human Elongator facilitates RNA polymerase II transcription through chromatin.",
"Structural insights into the function of Elongator.",
"Dimerization of elongator protein 1 is essential for Elongator complex assembly.",
"Structural insights into ... | [
1998,
2002,
2018,
2015,
2013
] | 5 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
4310
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
5,
1,
4,
5,
19,
2,
1,
4,
4,
1,
1,
7
] | 12 | true | Domain | ELP1, three-helical bundle | ELP1, three-helical bundle | HB_ELP1 | 4 |
IPR056171 | 56,171 | DNA polymerase II large subunit DP2, central domain | PolC_DP2_central_dom | Domain | 965 | false | false | This entry represents the central domain of DNA polymerase II large subunit from Pyrococcus abyssi (PolC) and similar sequences mainly found in archaea. This domain, which is found adjacent , shows an α-β configuration [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24844"
] | [
"PolC_DP2_central"
] | [
965
] | 1 | [
"EC",
"EC"
] | [
"2.7.7.7",
"3.1.11.1"
] | [
"EC:2.7.7.7",
"EC:3.1.11.1"
] | 2 | [
"5ijl",
"6hms",
"6knb",
"6knc",
"6t8h",
"8ppt",
"8ppu",
"8ppv",
"9f29",
"9f2a"
] | 10 | [
"PUB00154174",
"PUB00154175",
"PUB00155809",
"PUB00155810"
] | [
"33115459",
"32221299",
"27548043",
"30657780"
] | [
"Two conformations of DNA polymerase D-PCNA-DNA, an archaeal replisome complex, revealed by cryo-electron microscopy.",
"Structural basis for the increased processivity of D-family DNA polymerases in complex with PCNA.",
"Shared active site architecture between archaeal PolD and multi-subunit RNA polymerases re... | [
2020,
2020,
2016,
2019
] | 4 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Geodia barretti",
"ecological metagenomes"
] | [
904,
4,
1,
56
] | 4 | [] | [] | 0 | true | Domain | DNA polymerase II large subunit DP2, central domain | DNA polymerase II large subunit DP2, central domain | PolC_DP2_central_dom | 3 |
IPR056172 | 56,172 | DNA polymerase II large subunit DP2, catalytic domain | PolC_DP2_cat_dom | Domain | 889 | false | false | This entry represents the catalytic domain of DNA polymerase II large subunit from Pyrococcus abyssi (PolC) and similar sequences mainly found in archaea. This domain is found between and ; it shows a six-stranded double-psi β-barrel (DPBB) [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24846"
] | [
"PolC_DP2_cat"
] | [
889
] | 1 | [
"EC",
"EC"
] | [
"2.7.7.7",
"3.1.11.1"
] | [
"EC:2.7.7.7",
"EC:3.1.11.1"
] | 2 | [
"5ijl",
"6hms",
"6knb",
"6knc",
"6t8h",
"8ppt",
"8ppu",
"8ppv",
"9f29",
"9f2a"
] | 10 | [
"PUB00154174",
"PUB00154175",
"PUB00155809",
"PUB00155810"
] | [
"33115459",
"32221299",
"27548043",
"30657780"
] | [
"Two conformations of DNA polymerase D-PCNA-DNA, an archaeal replisome complex, revealed by cryo-electron microscopy.",
"Structural basis for the increased processivity of D-family DNA polymerases in complex with PCNA.",
"Shared active site architecture between archaeal PolD and multi-subunit RNA polymerases re... | [
2020,
2020,
2016,
2019
] | 4 | [] | [] | 0 | 0 | null | [
"Archaea",
"Geodia barretti",
"Thermodesulfobium narugense",
"ecological metagenomes"
] | [
836,
1,
2,
50
] | 4 | [] | [] | 0 | true | Domain | DNA polymerase II large subunit DP2, catalytic domain | DNA polymerase II large subunit DP2, catalytic domain | PolC_DP2_cat_dom | 1 |
IPR056173 | 56,173 | Sec20, C-terminal | Sec20_C | Domain | 5,628 | false | false | Sec20 is a membrane glycoprotein and a SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) involved in retrograde transport from the Golgi to the endoplasmic reticulum (ER) [ ]. It is also required for N- and O-glycosylation in the Golgi [ ]. This entry represents the C-terminal region of Sec2... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF03908"
] | [
"Sec20"
] | [
5628
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-6811434",
"R-MMU-6811434",
"R-RNO-6811434",
"R-SCE-6811434",
"R-SPO-6811434"
] | [
"REACTOME:R-HSA-6811434",
"REACTOME:R-MMU-6811434",
"REACTOME:R-RNO-6811434",
"REACTOME:R-SCE-6811434",
"REACTOME:R-SPO-6811434"
] | 5 | [
"8eki"
] | 1 | [
"PUB00010001",
"PUB00092570",
"PUB00092571"
] | [
"8334998",
"11477110",
"1537327"
] | [
"The TIP1 gene of Saccharomyces cerevisiae encodes an 80 kDa cytoplasmic protein that interacts with the cytoplasmic domain of Sec20p.",
"The yeast SEC20 gene is required for N- and O-glycosylation in the Golgi. Evidence that impaired glycosylation does not correlate with the secretory defect.",
"The Saccharomy... | [
1993,
2001,
1992
] | 3 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
5628
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
12,
1,
3,
1,
2,
2,
1,
13,
6,
1,
1,
17
] | 12 | true | Domain | Sec20, C-terminal | Sec20, C-terminal | Sec20_C | 5 |
IPR056174 | 56,174 | SpoVR protein-like, N-terminal | SpoVR_N | Domain | 8,188 | false | false | This entry represents a domain found at the N-terminal of the stage V sporulation protein R, YcgB from E.coli and related proteins. Stage V sporulation protein R is involved in spore cortex formation [ ]. Little is known about cortex biosynthesis, except that it depends on several sigma E controlled genes, including sp... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF04293"
] | [
"SpoVR"
] | [
8188
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00009937",
"PUB00010122",
"PUB00093610"
] | [
"8144469",
"8982457",
"29769716"
] | [
"Cloning and characterization of spoVR, a gene from Bacillus subtilis involved in spore cortex formation.",
"Molecular genetics of sporulation in Bacillus subtilis.",
"Mutant phenotypes for thousands of bacterial genes of unknown function."
] | [
1994,
1996,
2018
] | 3 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences",
"uncultured marine phage"
] | [
305,
7801,
16,
65,
1
] | 5 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Domain | SpoVR protein-like, N-terminal | SpoVR protein-like, N-terminal | SpoVR_N | 6 |
IPR056175 | 56,175 | Anti-CBASS protein Acb1-like, C-terminal domain | Acb1-like_C | Domain | 536 | false | false | This domain is found at the N terminus end of Anti-CBASS protein Acb1 from Sphingomonas paeninsulae [ ], covering the whole length of the protein in Bacteriophage T4 [ ] and in related sequences from tailed bacteriophages and proteobacterial prophages. Abc1 counteracts or regulates the endogenous CBASS (cyclic oligonuc... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23474"
] | [
"Acb1"
] | [
536
] | 1 | [] | [] | [] | 0 | [
"7t26",
"7t27",
"8hds",
"9q2g",
"9q2y"
] | 5 | [
"PUB00101341"
] | [
"35395152"
] | [
"Phage anti-CBASS and anti-Pycsar nucleases subvert bacterial immunity."
] | [
2022
] | 1 | [] | [] | 0 | 0 | null | [
"Didymodactylos carnosus",
"Pseudomonadati",
"Viruses",
"metagenomes"
] | [
2,
145,
384,
5
] | 4 | [] | [] | 0 | true | Domain | Anti-CBASS protein Acb1-like, C-terminal domain | Anti-CBASS protein Acb1-like, C-terminal domain | Acb1-like_C | 8 |
IPR056176 | 56,176 | COPA/B, TPR domain | TPR_COPA_B | Domain | 12,413 | false | false | This entry represents the TPR domain found in Coatomer subunits alpha and beta (COPA1-3, COPB2 and COB21-3), from eukaryotes. The domain adopts an α-solenoid fold. Coatomer complexes function in the sorting and trafficking of proteins between subcellular organelles [ ]. Coat protein I (COPI)-coated vesicles mediate ret... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23953"
] | [
"TPR_COPA_B"
] | [
12413
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-6807878",
"R-BTA-6811434",
"R-CEL-6807878",
"R-CEL-6811434",
"R-DDI-6807878",
"R-DDI-6811434",
"R-DME-6807878",
"R-DME-6811434",
"R-HSA-6807878",
"R-HSA-6811434",
"R-MMU-6807878",
"R-MMU-6811434",
"R-RNO-6807878",
"R-RNO-6811434",
"R-SCE-6807878",
"R-SCE-6811434",
"R-SPO-68078... | [
"REACTOME:R-BTA-6807878",
"REACTOME:R-BTA-6811434",
"REACTOME:R-CEL-6807878",
"REACTOME:R-CEL-6811434",
"REACTOME:R-DDI-6807878",
"REACTOME:R-DDI-6811434",
"REACTOME:R-DME-6807878",
"REACTOME:R-DME-6811434",
"REACTOME:R-HSA-6807878",
"REACTOME:R-HSA-6811434",
"REACTOME:R-MMU-6807878",
"REACTOM... | 18 | [
"3mkq",
"5a1u",
"5a1v",
"5a1w",
"5a1x",
"5a1y",
"5nzr",
"5nzs",
"5nzt",
"5nzu",
"5nzv",
"9qpq"
] | 12 | [
"PUB00100148",
"PUB00103201",
"PUB00155507",
"PUB00155508"
] | [
"31712447",
"34450031",
"34101128",
"32725128"
] | [
"Roles of singleton tryptophan motifs in COPI coat stability and vesicle tethering.",
"COPB2 loss of function causes a coatopathy with osteoporosis and developmental delay.",
"COPB2: a transport protein with multifaceted roles in cancer development and progression.",
"Mutations in COPA lead to abnormal traffi... | [
2019,
2021,
2021,
2020
] | 4 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
12413
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
28,
2,
3,
3,
9,
6,
2,
16,
13,
2,
2,
119
] | 12 | true | Domain | COPA/B, TPR domain | COPA/B, TPR domain | TPR_COPA_B | 8 |
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