LiteFold/InterPro · Datasets at Hugging Face

IPR056177

56,177

Corticotropin-releasing factor binding protein, N-terminal domain

CRF-BP_N

Domain

1,451

false

This entry corresponds to the N-terminal domain from eukaryotic corticotropin-releasing factor binding proteins (CRF-BP or CRH-BP). Corticotropin-releasing hormone (CRH) plays multiple roles in vertebrate species. In mammals, it is the major hypothalamic releasing factor for pituitary adrenocorticotropin secretion, and...

[]

0

[ "PFAM" ]

[ "PF05428" ]

[ "CRF-BP_N" ]

[ 1451 ]

1

[ "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-373080", "R-MMU-373080", "R-RNO-373080" ]

[ "REACTOME:R-HSA-373080", "REACTOME:R-MMU-373080", "REACTOME:R-RNO-373080" ]

3

[]

0

[ "PUB00011280" ]

[ "12379493" ]

[ "Corticotropin-releasing hormone-binding protein: biochemistry and function from fishes to mammals." ]

[ 2002 ]

1

[]

0

null

[ "Bilateria" ]

[ 1451 ]

1

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 2, 2, 3, 3 ]

5

true

Domain

Corticotropin-releasing factor binding protein, N-terminal domain

CRF-BP_N

4

IPR056178

56,178

Corticotropin-releasing factor binding protein, C-terminal domain

CRF-BP_C

Domain

1,393

false

This entry corresponds to the C-terminal domain of the eukaryotic corticotropin-releasing factor binding proteins (CRF-BP or CRH-BP). Corticotropin-releasing hormone (CRH) plays multiple roles in vertebrate species. In mammals, it is the major hypothalamic releasing factor for pituitary adrenocorticotropin secretion, a...

[]

0

[ "PFAM" ]

[ "PF23541" ]

[ "CRF-BP_C" ]

[ 1393 ]

1

[ "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-373080", "R-MMU-373080", "R-RNO-373080" ]

[ "REACTOME:R-HSA-373080", "REACTOME:R-MMU-373080", "REACTOME:R-RNO-373080" ]

3

[]

0

[ "PUB00011280" ]

[ "12379493" ]

[ "Corticotropin-releasing hormone-binding protein: biochemistry and function from fishes to mammals." ]

[ 2002 ]

1

[]

0

null

[ "Bilateria" ]

[ 1393 ]

1

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 2, 2, 4, 3 ]

5

true

Domain

Corticotropin-releasing factor binding protein, C-terminal domain

CRF-BP_C

1

IPR056179

56,179

3-dehydroquinate synthase, C-terminal domain

DHQS_C

Domain

34,177

false

This entry represents the C-terminal domain of 3-dehydroquinate synthase (DHQS) and related proteins. This domain contains most of the residues involved in catalysis and in substrate and Zn2+ binding [ ]. This domain is also found in AROM proteins which are pentafunctional enzymes that catalyse 5 consecutive enzymatic ...

[]

0

[ "PFAM", "PFAM" ]

[ "PF24621", "PF26558" ]

[ "DHQS_C", "DHQS_2nd" ]

[ 31655, 2522 ]

2

[ "EC", "EC", "METACYC", "REACTOME" ]

[ "4.2.3", "4.2.3.4", "PWY-6164", "R-MTU-964903" ]

[ "EC:4.2.3", "EC:4.2.3.4", "METACYC:PWY-6164", "REACTOME:R-MTU-964903" ]

4

[ "1dqs", "1nr5", "1nrx", "1nua", "1nva", "1nvb", "1nvd", "1nve", "1nvf", "1sg6", "1ujn", "1xag", "1xah", "1xai", "1xaj", "1xal", "2d2x", "2gru", "3clh", "3okf", "3qbd", "3qbe", "3zok", "4p53", "5eks", "5hvn", "5tpr", "6c5c", "6hqv", "6lk2", "6lla", "7u5s"...

34

[ "PUB00001459", "PUB00003775", "PUB00024300", "PUB00060486", "PUB00109170" ]

[ "7556173", "9613570", "9685163", "15182204", "17010158" ]

[ "The molecular biology of multidomain proteins. Selected examples.", "Cloning and characterisation of the Neisseria gonorrhoeae aroB gene.", "Structure of dehydroquinate synthase reveals an active site capable of multistep catalysis.", "L-Aspartate semialdehyde and a 6-deoxy-5-ketohexose 1-phosphate are the p...

[ 1995, 1998, 1998, 2004, 2006 ]

5

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 854, 27427, 5201, 2, 693 ]

5

[ "Arabidopsis thaliana", "Danio rerio", "Escherichia coli (strain K12)", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)",...

[ 10, 6, 1, 1, 5, 1, 1, 26 ]

8

true

Domain

3-dehydroquinate synthase, C-terminal domain

DHQS_C

6

IPR056180

56,180

ZPR1, jelly-roll domain

ZPR1_jr_dom

Domain

5,554

false

This entry represents the jelly-roll domain found in ZPR1 family. This entry consists of zinc finger protein ZPR1 and ZPR1-like proteins. The function of ZPR1 from archaea and eukaryotes is not yet clear. However, Zpr1 from yeast acts as a protein folding chaperone for elongation factor 1-alpha [ ]. ZPR1 is present in ...

[]

0

[ "PFAM" ]

[ "PF22794" ]

[ "jr-ZPR1" ]

[ 5554 ]

1

[]

0

[ "2qkd" ]

1

[ "PUB00017397", "PUB00020594", "PUB00035839", "PUB00090578", "PUB00090579", "PUB00103908" ]

[ "8650580", "9852145", "17068332", "23029159", "27411854", "36630955" ]

[ "Binding of zinc finger protein ZPR1 to the epidermal growth factor receptor.", "Interaction of ZPR1 with translation elongation factor-1alpha in proliferating cells.", "Deficiency of the zinc finger protein ZPR1 causes defects in transcription and cell cycle progression.", "Drosophila Zpr1 (Zinc finger prote...

[ 1996, 1998, 2006, 2012, 2016, 2023 ]

6

[]

0

null

[ "Archaea", "Eukaryota", "ecological metagenomes" ]

[ 458, 5079, 17 ]

3

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 17, 2, 1, 1, 5, 8, 1, 2, 4, 1, 1, 9 ]

12

true

Domain

ZPR1, jelly-roll domain

ZPR1_jr_dom

8

IPR056181

56,181

SH3BP4, C-terminal helical domain

SH3BP4_C

Domain

2,089

false

The domain represented by this entry is predicted to fold into a mainly helical structure with a DEATH domain-like topology. This entry includes SH3 domain-binding protein 4 (SH3BP4) and related proteins such as Metastasis-associated in colon cancer protein 1 (MACC1). SH3BP4 binds and negative regulates Rag GTPase comp...

[]

0

[ "PFAM" ]

[ "PF23637" ]

[ "SH3BP4_C" ]

[ 2089 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-DRE-9639288", "R-HSA-9639288", "R-MMU-9639288", "R-RNO-9639288", "R-XTR-9639288" ]

[ "REACTOME:R-DRE-9639288", "REACTOME:R-HSA-9639288", "REACTOME:R-MMU-9639288", "REACTOME:R-RNO-9639288", "REACTOME:R-XTR-9639288" ]

5

[]

0

[ "PUB00085389", "PUB00155838" ]

[ "22575674", "19098908" ]

[ "SH3BP4 is a negative regulator of amino acid-Rag GTPase-mTORC1 signaling.", "MACC1, a newly identified key regulator of HGF-MET signaling, predicts colon cancer metastasis." ]

[ 2012, 2009 ]

2

[]

0

null

[ "Chordata" ]

[ 2089 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 14, 4, 3, 5 ]

4

true

Domain

SH3BP4, C-terminal helical domain

SH3BP4_C

4

IPR056182

56,182

SH3BP4, UPA-like domain

UPA_SH3BP4

Domain

2,600

false

The domain represented by this entry is predicted to fold into a β-sandwich with Ig-like topology and significant similarity to UPA domain. This entry includes SH3 domain-binding protein 4 (SH3BP4) and related proteins such as Metastasis-associated in colon cancer protein 1 (MACC1). SH3BP4 binds and negative regulates ...

[]

0

[ "PFAM" ]

[ "PF23640" ]

[ "UPA_SH3BP4" ]

[ 2600 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-DRE-9639288", "R-HSA-9639288", "R-MMU-9639288", "R-RNO-9639288", "R-XTR-9639288" ]

[ "REACTOME:R-DRE-9639288", "REACTOME:R-HSA-9639288", "REACTOME:R-MMU-9639288", "REACTOME:R-RNO-9639288", "REACTOME:R-XTR-9639288" ]

5

[]

0

[ "PUB00085389", "PUB00155838" ]

[ "22575674", "19098908" ]

[ "SH3BP4 is a negative regulator of amino acid-Rag GTPase-mTORC1 signaling.", "MACC1, a newly identified key regulator of HGF-MET signaling, predicts colon cancer metastasis." ]

[ 2012, 2009 ]

2

[]

0

null

[ "Chordata" ]

[ 2600 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 14, 3, 2, 6 ]

4

true

Domain

SH3BP4, UPA-like domain

UPA_SH3BP4

8

IPR056183

56,183

SH3BP4, DEATH domain-like

DEATH_SH3BP4

Domain

2,203

false

This domain is found towards the C-terminal of SH3BP4 and MACC1. This domain, which is often found N-terminal to , is predicted to show a DEATH domain-like all-α structure. This entry includes SH3 domain-binding protein 4 (SH3BP4) and related proteins such as Metastasis-associated in colon cancer protein 1 (MACC1). SH3...

[]

0

[ "PFAM" ]

[ "PF24094" ]

[ "DEATH_SH3BP4" ]

[ 2203 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-DRE-9639288", "R-HSA-9639288", "R-MMU-9639288", "R-RNO-9639288", "R-XTR-9639288" ]

[ "REACTOME:R-DRE-9639288", "REACTOME:R-HSA-9639288", "REACTOME:R-MMU-9639288", "REACTOME:R-RNO-9639288", "REACTOME:R-XTR-9639288" ]

5

[]

0

[ "PUB00085389", "PUB00155838" ]

[ "22575674", "19098908" ]

[ "SH3BP4 is a negative regulator of amino acid-Rag GTPase-mTORC1 signaling.", "MACC1, a newly identified key regulator of HGF-MET signaling, predicts colon cancer metastasis." ]

[ 2012, 2009 ]

2

[]

0

null

[ "Chordata" ]

[ 2203 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 14, 4, 3, 6 ]

4

true

Domain

SH3BP4, DEATH domain-like

DEATH_SH3BP4

5

IPR056184

56,184

BTBD17, TRAF domain

TRAF_BTBD17

Domain

1,426

false

This domain is found in human BTB/POZ domain-containing protein 17 and related proteins. It is predicted to adopt a β-sandwich with permuted Ig-like topology. It has a significant sequence and structural similarity to TRAF domains.

[]

0

[ "PFAM" ]

[ "PF23651" ]

[ "TRAF_BTBD17" ]

[ 1426 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bilateria" ]

[ 1426 ]

1

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 13, 1, 1, 1, 4 ]

5

true

Domain

BTBD17, TRAF domain

TRAF_BTBD17

7

IPR056185

56,185

LYR motif containing domain, plants

LYRM_2_plant

Domain

560

false

This domain is found in uncharacterised plant proteins. It is predicted to fold into a three helical up-and-down bundle. It shares sequence similarity to LYR motif containing domains and has the motif conserved.

[]

0

[ "PFAM" ]

[ "PF23655" ]

[ "LYRM_2" ]

[ 560 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Eukaryota" ]

[ 560 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 6, 4, 7 ]

3

true

Domain

LYR motif containing domain, plants

LYRM_2_plant

5

IPR056186

56,186

CPAF-like, PDZ domain

PDZ_CPAF-rel

Domain

3,026

false

This domain is found in fungal proteins that share global similarity to chlamydial protease/proteasome-like activity factor (CPAF). Amongst these proteins are peptidase S41 family proteins phomP1, phomP1' and ustP. This domain is predicted to adopt PDZ-like fold and shares sequence similarity with CPAF PDZ domain.

[]

0

[ "PFAM" ]

[ "PF23658" ]

[ "PDZ_CPAF_rel" ]

[ 3026 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Eukaryota" ]

[ 3026 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)" ]

[ 2 ]

1

true

Domain

CPAF-like, PDZ domain

PDZ_CPAF-rel

8

IPR056187

56,187

NOMO, eighth prealbumin-like domain

NOMO_8th

Domain

2,279

false

This domain is found in the NOMO family of proteins. This entry represents the eighth domain that is predicted to fold into a β-sandwich with prealbumin-like topology. NOMO family of proteins includes NOMO1, NOMO2, NOMO3. These proteins are components of the multi-pass translocon (MPT) complex that mediates insertion o...

[]

0

[ "PFAM" ]

[ "PF23660" ]

[ "NOMO_8th" ]

[ 2279 ]

1

[]

0

[ "9c7v" ]

1

[ "PUB00097241", "PUB00103609" ]

[ "32820719", "36261522" ]

[ "An ER translocon for multi-pass membrane protein biogenesis.", "Substrate-driven assembly of a translocon for multipass membrane proteins." ]

[ 2020, 2022 ]

2

[]

0

null

[ "Eukaryota" ]

[ 2279 ]

1

[ "Arabidopsis thaliana", "Danio rerio", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 7, 1, 11, 1, 1, 3, 13 ]

7

true

Domain

NOMO, eighth prealbumin-like domain

NOMO_8th

8

IPR056188

56,188

NOMO, sixth transthyretin-like domain

NOMO_6th

Domain

744

false

This domain is found in NOMO family of proteins and has a weak sequence similarity to transthyretin-like domains. It is predicted to adopt a similar structure that consists of seven-stranded β-sandwich. NOMO proteins are predicted to contain a tandem of twelve transthyretin-like domains of which this is the sixth. NOMO...

[]

0

[ "PFAM" ]

[ "PF23196" ]

[ "NOMO_6th" ]

[ 744 ]

1

[]

0

[]

0

[ "PUB00097241", "PUB00103609" ]

[ "32820719", "36261522" ]

[ "An ER translocon for multi-pass membrane protein biogenesis.", "Substrate-driven assembly of a translocon for multipass membrane proteins." ]

[ 2020, 2022 ]

2

[]

0

null

[ "Eukaryota" ]

[ 744 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 4, 1, 11 ]

3

true

Domain

NOMO, sixth transthyretin-like domain

NOMO_6th

6

IPR056189

56,189

NOMO, third transthyretin-like domain

NOMO_3rd

Domain

2,417

false

This domain is found in NOMO family of proteins which has a weak sequence similarity to transthyretin-like domains and it is predicted to adopt similar structure that consists of seven-stranded β-sandwich. NOMO are predicted to contain a tandem of twelve transthyretin-like domains and this domain is the third in the ta...

[]

0

[ "PFAM" ]

[ "PF23193" ]

[ "NOMO_3rd" ]

[ 2417 ]

1

[]

0

[ "9c7v" ]

1

[ "PUB00097241", "PUB00103609" ]

[ "32820719", "36261522" ]

[ "An ER translocon for multi-pass membrane protein biogenesis.", "Substrate-driven assembly of a translocon for multipass membrane proteins." ]

[ 2020, 2022 ]

2

[]

0

null

[ "Eukaryota", "Pseudomonadati" ]

[ 2410, 7 ]

2

[ "Arabidopsis thaliana", "Danio rerio", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 7, 1, 11, 1, 1, 3, 11 ]

7

true

Domain

NOMO, third transthyretin-like domain

NOMO_3rd

4

IPR056190

56,190

NOMO, fifth transthyretin-like domain

NOMO_5th

Domain

2,951

false

This domain is found in NOMO family and related proteins. NOMO proteins are predicted to contain a tandem of twelve Transthyretin-like domains and this domain is the fifth in the tandem. NOMO family of proteins includes NOMO1, NOMO2, NOMO3. These proteins are components of the multi-pass translocon (MPT) complex that m...

[]

0

[ "PFAM" ]

[ "PF23194" ]

[ "NOMO_5th" ]

[ 2951 ]

1

[]

0

[ "9c7v" ]

1

[ "PUB00097241", "PUB00103609" ]

[ "32820719", "36261522" ]

[ "An ER translocon for multi-pass membrane protein biogenesis.", "Substrate-driven assembly of a translocon for multipass membrane proteins." ]

[ 2020, 2022 ]

2

[]

0

null

[ "Candidatus Daviesbacteria bacterium GW2011_GWA2_40_9", "Eukaryota" ]

[ 1, 2950 ]

2

[ "Arabidopsis thaliana", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 7, 1, 4, 13, 1, 1, 3, 13 ]

8

true

Domain

NOMO, fifth transthyretin-like domain

NOMO_5th

7

IPR056191

56,191

NOMO, C-terminal transthyretin-like domain

NOMO_12th

Domain

2,207

false

This domain is found at the C-terminal of NOMO family of proteins. The domain represented by this entry has a weak sequence similarity to transthyretin-like domains and it is predicted to adopt similar structure that consists of seven-stranded β-sandwich. NOMO family of proteins includes NOMO1, NOMO2, NOMO3. These prot...

[]

0

[ "PFAM" ]

[ "PF23192" ]

[ "NOMO_12th" ]

[ 2207 ]

1

[]

0

[ "9c7u", "9c7v" ]

2

[ "PUB00097241", "PUB00103609" ]

[ "32820719", "36261522" ]

[ "An ER translocon for multi-pass membrane protein biogenesis.", "Substrate-driven assembly of a translocon for multipass membrane proteins." ]

[ 2020, 2022 ]

2

[]

0

null

[ "Eukaryota" ]

[ 2207 ]

1

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 5, 13, 1, 3 ]

5

true

Domain

NOMO, C-terminal transthyretin-like domain

NOMO_12th

1

IPR056192

56,192

NPAS4, bHLH domain

bHLH_NPAS4

Domain

1,849

false

This bHLH domain is found in the family of Neuronal PAS domain-containing protein 4 (NPAS4). NPAS4 is a transcription factor expressed in neurons of the brain that regulates the excitatory-inhibitory balance within neural circuits and is required for contextual memory in the hippocampus [ ]. It binds to DNA but efficie...

[]

0

[ "PFAM" ]

[ "PF23183" ]

[ "bHLH_NPAS4" ]

[ 1849 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-CEL-9768919", "R-DRE-9768919", "R-HSA-9768778", "R-HSA-9768919", "R-MMU-9768919", "R-RNO-9768919" ]

[ "REACTOME:R-CEL-9768919", "REACTOME:R-DRE-9768919", "REACTOME:R-HSA-9768778", "REACTOME:R-HSA-9768919", "REACTOME:R-MMU-9768919", "REACTOME:R-RNO-9768919" ]

6

[ "7xhv", "7xi3", "7xi4" ]

3

[ "PUB00149730", "PUB00155557", "PUB00155558" ]

[ "14701734", "18815592", "15363889" ]

[ "Identification of a novel basic helix-loop-helix-PAS factor, NXF, reveals a Sim2 competitive, positive regulatory role in dendritic-cytoskeleton modulator drebrin gene expression.", "Activity-dependent regulation of inhibitory synapse development by Npas4.", "LE-PAS, a novel Arnt-dependent HLH-PAS protein, is ...

[ 2004, 2008, 2004 ]

3

[ "IPR011598" ]

[]

1

0

1

[ "Bilateria" ]

[ 1849 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 5, 7, 1, 3, 2 ]

6

true

Domain

NPAS4, bHLH domain

bHLH_NPAS4

1

IPR056193

56,193

Nuclear receptor coactivator 1-3, bHLH domain

bHLH_NCOA1-3

Domain

4,864

false

This bHLH domain is found in nuclear receptor coactivators NCOA1, NCOA2, and NCOA3. The NCOAs bind to nuclear hormone receptors in a ligand-dependent manner and mediate the transcriptional activation of the downstream target genes in response to hormones, metabolites, xenobiotics, and drugs. They are transcriptional co...

[]

0

[ "PFAM" ]

[ "PF23172" ]

[ "bHLH_NCOA" ]

[ 4864 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-DRE-159418", "R-DRE-3214847", "R-DRE-400206", "R-DRE-5625886", "R-DRE-9707564", "R-HSA-1368108", "R-HSA-159418", "R-HSA-192105", "R-HSA-193368", "R-HSA-193807", "R-HSA-1989781", "R-HSA-211976", "R-HSA-2151201", "R-HSA-2426168", "R-HSA-3214847", "R-HSA-381340", "R-HSA-3899300", "...

[ "REACTOME:R-DRE-159418", "REACTOME:R-DRE-3214847", "REACTOME:R-DRE-400206", "REACTOME:R-DRE-5625886", "REACTOME:R-DRE-9707564", "REACTOME:R-HSA-1368108", "REACTOME:R-HSA-159418", "REACTOME:R-HSA-192105", "REACTOME:R-HSA-193368", "REACTOME:R-HSA-193807", "REACTOME:R-HSA-1989781", "REACTOME:R-HS...

61

[]

0

[ "PUB00069384", "PUB00149292", "PUB00156025" ]

[ "9430642", "8670870", "23508108" ]

[ "The coactivator TIF2 contains three nuclear receptor-binding motifs and mediates transactivation through CBP binding-dependent and -independent pathways.", "TIF2, a 160 kDa transcriptional mediator for the ligand-dependent activation function AF-2 of nuclear receptors.", "RSUME enhances glucocorticoid receptor...

[ 1998, 1996, 2013 ]

3

[ "IPR011598" ]

[ "IPR028819", "IPR028822", "IPR056194" ]

1

3

0

[ "Bilateria" ]

[ 4864 ]

1

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 13, 6, 10, 17, 11 ]

5

true

Domain

Nuclear receptor coactivator 1-3, bHLH domain

bHLH_NCOA1-3

4

IPR056194

56,194

Nuclear receptor coactivator 3, basic helix-loop-helix

NCOA3_bHLH

Domain

535

false

This entry represents the N-terminal basic helix-loop-helix domain of Nuclear receptor coactivator 3. NCoA-3, also termed ACTR, or amplified in breast cancer 1 protein (AIB-1), or CBP-interacting protein (pCIP), or Class E basic helix-loop-helix protein 42 (bHLHe42), or receptor-associated coactivator 3 (RAC-3), or ste...

[]

0

[ "CDD" ]

[ "cd18949" ]

[ "bHLH-PAS_NCoA3_SRC3" ]

[ 535 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-1989781", "R-HSA-381340", "R-HSA-5617472", "R-HSA-5687128", "R-HSA-9018519", "R-HSA-9841922" ]

[ "REACTOME:R-HSA-1989781", "REACTOME:R-HSA-381340", "REACTOME:R-HSA-5617472", "REACTOME:R-HSA-5687128", "REACTOME:R-HSA-9018519", "REACTOME:R-HSA-9841922" ]

6

[]

0

[ "PUB00059610", "PUB00069373", "PUB00075164", "PUB00088129", "PUB00106946", "PUB00106952", "PUB00106953", "PUB00107473", "PUB00107474", "PUB00107475", "PUB00107476", "PUB00107478", "PUB00107479", "PUB00107480", "PUB00107482", "PUB00107483", "PUB00107484", "PUB00107485", "PUB001074...

[ "16951154", "10713439", "17998543", "12917342", "14643885", "20112293", "16520375", "12024042", "12805412", "15300201", "16423883", "16957778", "15698540", "11971985", "11094166", "10490106", "9727751", "9238002", "9252329", "9267036", "9346901", "23795583", "23559371" ]

[ "Male germ cell-associated kinase, a male-specific kinase regulated by androgen, is a coactivator of androgen receptor in prostate cancer cells.", "The SRC family of nuclear receptor coactivators.", "ANCCA, an estrogen-regulated AAA+ ATPase coactivator for ERalpha, is required for coregulator occupancy and chro...

[ 2006, 2000, 2007, 2003, 2004, 2010, 2006, 2002, 2003, 2004, 2006, 2006, 2004, 2002, 2000, 1999, 1998, 1997, 1997, 1997, 1997, 2013, 2013 ]

23

[ "IPR056193" ]

[]

1

0

1

[ "Gnathostomata" ]

[ 535 ]

1

[ "Homo sapiens" ]

[ 5 ]

1

true

Domain

Nuclear receptor coactivator 3, basic helix-loop-helix

NCOA3_bHLH

6

IPR056195

56,195

HTH 3-helical bundle

HTH_70

Domain

393

false

This domain is found in uncharacterised plant proteins. It shares significant sequence similarity to HTH 3-helical bundle domains and it is predicted to adopt similar structure.

[]

0

[ "PFAM" ]

[ "PF23671" ]

[ "HTH_70" ]

[ 393 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Eukaryota" ]

[ 393 ]

1

[ "Oryza sativa subsp. japonica", "Zea mays" ]

[ 10, 17 ]

2

true

Domain

HTH 3-helical bundle

HTH_70

1

IPR056196

56,196

Mmc1, C-terminal domain

Mmc1_C

Domain

1,364

false

This domain is found at the C-terminal of Mmc1 from Schizosaccharomyces pombe ( ) and related proteins. Mmc1 functions in concert with the mitochondrial contact site and cristae organizing system (MICOS) complex to promote normal mitochondrial morphology and respiratory function [ ]. This domain is predicted to adopt a...

[]

0

[ "PFAM" ]

[ "PF23868" ]

[ "Mmc1_C" ]

[ 1364 ]

1

[]

0

[]

0

[ "PUB00155748" ]

[ "38692277" ]

[ "A dynamin superfamily-like pseudoenzyme coordinates with MICOS to promote cristae architecture." ]

[ 2024 ]

1

[]

0

null

[ "Eukaryota" ]

[ 1364 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 1 ]

2

true

Domain

Mmc1, C-terminal domain

Mmc1_C

4

IPR056198

56,198

Putative ionotropic receptor, ligand binding domain

LBD_receptor

Domain

1,004

false

This domain is found in a set of putative arthropod ionotropic receptors. It is predicted to adopt an α/β structure with similarity to known ligand binding domains of ionotropic receptors such as .

[]

0

[ "PFAM" ]

[ "PF24061" ]

[ "LBD_receptor" ]

[ 1004 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Neoptera" ]

[ 1004 ]

1

[ "Drosophila melanogaster" ]

[ 7 ]

1

true

Domain

Putative ionotropic receptor, ligand binding domain

LBD_receptor

4

IPR056199

56,199

SPEF2, C-terminal domain

SPEF2_C

Domain

1,260

false

This domain is found in the axoneme central apparatus (CA) associated proteins such as Chlamydomonas Central pair complex 1 (CPC1, ) and its mammalian orthologues Sperm flagellar protein 2 (SPEF2) [ , ]. CPC1 is located at C1 microtubule. Most of the distal components of the C1b projection bind CPC1 and its correct rec...

[]

0

[ "PFAM" ]

[ "PF24082" ]

[ "SPEF2_C" ]

[ 1260 ]

1

[]

0

[ "7n6g", "7sqc", "9ijj" ]

3

[ "PUB00153933", "PUB00154240", "PUB00154241" ]

[ "35578023", "15292403", "31545650" ]

[ "Ciliary central apparatus structure reveals mechanisms of microtubule patterning.", "Cpc1, a Chlamydomonas central pair protein with an adenylate kinase domain.", "SPEF2- and HYDIN-Mutant Cilia Lack the Central Pair-associated Protein SPEF2, Aiding Primary Ciliary Dyskinesia Diagnostics." ]

[ 2022, 2004, 2020 ]

3

[]

0

null

[ "Eukaryota" ]

[ 1260 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 9, 2, 1, 5 ]

4

true

Domain

SPEF2, C-terminal domain

SPEF2_C

5

IPR056200

56,200

Neurotrophin 1, N-terminal

NT_N

Domain

243

false

This domain is found N-terminal in fruit fly Neurotrophin 1 (NT) and related proteins from arthropods. NT binds to Toll-7 and probably acts as its ligand in promoting motor axon targeting and neuronal survival in the central nervous system (CNS) [ ]. In larvae, NT is involved in the negative regulation of the tracheal ...

[]

0

[ "PFAM" ]

[ "PF24103" ]

[ "NT_N" ]

[ 243 ]

1

[]

0

[]

0

[ "PUB00155765", "PUB00155766" ]

[ "23892553", "22022271" ]

[ "Toll-6 and Toll-7 function as neurotrophin receptors in the Drosophila melanogaster CNS.", "Toll-8/Tollo negatively regulates antimicrobial response in the Drosophila respiratory epithelium." ]

[ 2013, 2011 ]

2

[]

0

null

[ "Pterygota" ]

[ 243 ]

1

[ "Drosophila melanogaster" ]

[ 3 ]

1

true

Domain

Neurotrophin 1, N-terminal

NT_N

2

IPR056201

56,201

Type I-B CRISPR Cas8b, N-terminal domain

Cas8b_N

Domain

38

false

This entry represents the N-terminal domain of Type I-B CRISPR Synechocystis Cas8b and related proteins. Type I CRISPR-Cas systems employ multi-subunit effector Cascade and helicase-nuclease Cas3 to target and degrade foreign nucleic acids, representing the most abundant RNA-guided adaptive immune systems in prokaryote...

[]

0

[ "PFAM" ]

[ "PF24121" ]

[ "Cas8b_N" ]

[ 38 ]

1

[]

0

[ "8h67", "8ip0" ]

2

[ "PUB00155573" ]

[ "38750051" ]

[ "Structure and genome editing of type I-B CRISPR-Cas." ]

[ 2024 ]

1

[]

0

null

[ "Bacteria" ]

[ 38 ]

1

[]

0

true

Domain

Type I-B CRISPR Cas8b, N-terminal domain

Cas8b_N

7

IPR056202

56,202

Type I-B CRISPR Cas8b, C-terminal domain

Cas8b_C

Domain

41

false

This entry represents the C-terminal domain of Type I-B CRISPR Synechocystis Cas8b and related proteins. Type I CRISPR-Cas systems employ multi-subunit effector Cascade and helicase-nuclease Cas3 to target and degrade foreign nucleic acids, representing the most abundant RNA-guided adaptive immune systems in prokaryote...

[]

0

[ "PFAM" ]

[ "PF24122" ]

[ "Cas8b_C" ]

[ 41 ]

1

[]

0

[ "8h67", "8h7q", "8ip0" ]

3

[ "PUB00155573" ]

[ "38750051" ]

[ "Structure and genome editing of type I-B CRISPR-Cas." ]

[ 2024 ]

1

[]

0

null

[ "Bacteria" ]

[ 41 ]

1

[]

0

true

Domain

Type I-B CRISPR Cas8b, C-terminal domain

Cas8b_C

2

IPR056204

56,204

K1 capsule-specific polysaccharide lyase, C-terminal domain

K1-lyase_C

Domain

105

false

This entry represents the C-terminal domain of K1 capsule-specific polysaccharide lyase from Klebsiella phages and related proteins. This domain adopts a β-sandwich fold [ ]. K1-lyase functions as a receptor binding protein (RBP) and mediates the attachment to the host capsular exopolysaccharides [ ]. This enzyme posse...

[]

0

[ "PFAM" ]

[ "PF24146" ]

[ "K1-lyase_C" ]

[ 105 ]

1

[]

0

[ "7eea", "7w1c", "7w1d", "7w1e" ]

4

[ "PUB00155689" ]

[ "35130876" ]

[ "Structural and biological insights into Klebsiella pneumoniae surface polysaccharide degradation by a bacteriophage K1 lyase: implications for clinical use." ]

[ 2022 ]

1

[]

0

null

[ "Bacteria", "Candidatus Iainarchaeum sp.", "Caudoviricetes", "Chlorophyta", "metagenomes" ]

[ 64, 1, 34, 2, 4 ]

5

[]

0

true

Domain

K1 capsule-specific polysaccharide lyase, C-terminal domain

K1-lyase_C

3

IPR056205

56,205

Meg

Domain

163

false

This entry includes Maternally expressed gene (Meg) family of proteins, a multigene family expressed in maize that encodes cysteine-rich proteins. The founding member of the family, Meg1, is required for normal development of the basal endosperm transfer cell layer and is involved in the allocation of maternal nutrient...

[]

0

[ "PFAM" ]

[ "PF24153" ]

[ "Meg" ]

[ 163 ]

1

[]

0

[ "7dab" ]

1

[ "PUB00155738", "PUB00155739" ]

[ "22245001", "25084677" ]

[ "Maternal control of nutrient allocation in plant seeds by genomic imprinting.", "Adaptive expansion of the maize maternally expressed gene (Meg) family involves changes in expression patterns and protein secondary structures of its members." ]

[ 2012, 2014 ]

2

[]

0

null

[ "Mesangiospermae" ]

[ 163 ]

1

[ "Zea mays" ]

[ 25 ]

1

true

Domain

Meg

8

IPR056206

56,206

Immune protein Tis1

Tis1_ImmP

Family

52

false

Tas1 is a type VI secretion effector in the pathogen Pseudomonas aeruginosa that synthesises (p)ppApp. Its cognate immunity protein Tis1 is represented by this entry. Binding of the immunity protein probably neutralises Tas1-mediated toxicity by inducing structural rearrangement in the acceptor nucleotide binding site ...

[]

0

[ "PFAM" ]

[ "PF24154" ]

[ "Tis1_ImmP" ]

[ 52 ]

1

[]

0

[ "6ox6" ]

1

[ "PUB00155863" ]

[ "31695193" ]

[ "An interbacterial toxin inhibits target cell growth by synthesizing (p)ppApp." ]

[ 2019 ]

1

[]

0

null

[ "Bacteria" ]

[ 52 ]

1

[]

0

true

Family

Immune protein Tis1

Tis1_ImmP

7

IPR056207

56,207

Tape measure protein PB2, N-terminal

TMP_PB2_N

Domain

230

false

This entry represents the N-terminal conserved region of the Tape measure protein PB2 and related proteins found mainly in T5-like phages. PB2 functions as a tape measure protein that serves as a base for tail tube protein polymerisation and acts as a template for tail length determination [ , ]. This protein fills the...

[]

0

[ "PFAM" ]

[ "PF24164" ]

[ "TMP_N" ]

[ 230 ]

1

[]

0

[ "7zhj", "7zn2", "7zqb", "7zqp", "8hqo", "8hqz" ]

6

[ "PUB00155631", "PUB00155646", "PUB00155867" ]

[ "36961893", "38081816", "18348984" ]

[ "Structural basis of bacteriophage T5 infection trigger and E. coli cell wall perforation.", "Nearly complete structure of bacteriophage DT57C reveals architecture of head-to-tail interface and lateral tail fibers.", "Phage T5 straight tail fiber is a multifunctional protein acting as a tape measure and ...

[ 2023, 2023, 2008 ]

3

[]

0

null

[ "Viruses" ]

[ 230 ]

1

[]

0

true

Domain

Tape measure protein PB2, N-terminal

TMP_PB2_N

1

IPR056208

56,208

Tape measure protein PB2, C-terminal

TMP_PB2_C

Domain

207

false

This entry represents the C-terminal conserved region of the Tape measure protein PB2 and related proteins found mainly in T5-like phages. PB2 functions as a tape measure protein that serves as a base for tail tube protein polymerisation and acts as a template for tail length determination [ , ]. This protein fills the...

[]

0

[ "PFAM" ]

[ "PF24165" ]

[ "TMP_C" ]

[ 207 ]

1

[]

0

[ "7zhj", "7zn2", "7zqb", "7zqp", "8hqo", "8hqz" ]

6

[ "PUB00155631", "PUB00155646", "PUB00155867" ]

[ "36961893", "38081816", "18348984" ]

[ "Structural basis of bacteriophage T5 infection trigger and E. coli cell wall perforation.", "Nearly complete structure of bacteriophage DT57C reveals architecture of head-to-tail interface and lateral tail fibers.", "Phage T5 straight tail fiber is a multifunctional protein acting as a tape measure and ...

[ 2023, 2023, 2008 ]

3

[]

0

null

[ "Viruses" ]

[ 207 ]

1

[]

0

true

Domain

Tape measure protein PB2, C-terminal

TMP_PB2_C

7

IPR056209

56,209

SU10 adaptor protein

SU10_adaptor

Family

2,244

false

This entry represents adaptor proteins found in SU10-like bacteriophages and prophages. The dodecamer of SU10 adaptor proteins forms the interface between the dodecamer of portal proteins and hexamer of nozzle proteins [ ]. The adaptor complex provides six attachment sites for long tail fibres, each of which is formed ...

[]

0

[ "PFAM" ]

[ "PF24175" ]

[ "SU10_adaptor" ]

[ 2244 ]

1

[]

0

[ "7z47", "7z4a", "7z4b", "7z4f", "8jov", "8zkk", "8zkm", "9k09", "9lc0", "9nwi" ]

10

[ "PUB00153713" ]

[ "36153309" ]

[ "Tail proteins of phage SU10 reorganize into the nozzle for genome delivery." ]

[ 2022 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 6, 1261, 5, 538, 434 ]

5

[]

0

true

Family

SU10 adaptor protein

SU10_adaptor

2

IPR056210

56,210

Effector protein Avr2-like

Avr2-like

Family

28

false

This entry represents Fusarium oxysporum Avr2 effector protein ( ) and similar sequences from ascomycetes. Avr2 targets a conserved defence mechanism in different hosts. It also suppresses FLS2-mediated immune responses, such as growth inhibition, ROS production, MAPK activation and callose deposition following flagell...

[]

0

[ "PFAM" ]

[ "PF24180" ]

[ "Avr2" ]

[ 28 ]

1

[]

0

[ "5od4" ]

1

[ "PUB00155505" ]

[ "28857169" ]

[ "Structure-function analysis of the Fusarium oxysporum Avr2 effector allows uncoupling of its immune-suppressing activity from recognition." ]

[ 2017 ]

1

[]

0

null

[ "sordariomyceta" ]

[ 28 ]

1

[]

0

true

Family

Effector protein Avr2-like

Avr2-like

4

IPR056211

56,211

T2SS substrate NttC-like

NttC-like

Family

75

false

This entry represents the T2SS protein NttC from Legionella pneumophila ( ) and related proteins found mainly in other Legionella species. NttC has a key role during L.pneumophila infection of Vermamoeba vermiformis and Willaertia magna amoebas. It folds into an Ig-like β-sandwich containing ten β-strands and an α-heli...

[]

0

[ "PFAM" ]

[ "PF24268" ]

[ "NttC" ]

[ 75 ]

1

[]

0

[ "6sjt" ]

1

[ "PUB00155764" ]

[ "32656228" ]

[ "Structure, Dynamics and Cellular Insight Into Novel Substrates of the Legionella pneumophila Type II Secretion System." ]

[ 2020 ]

1

[]

0

null

[ "Gammaproteobacteria" ]

[ 75 ]

1

[]

0

true

Family

T2SS substrate NttC-like

NttC-like

1

IPR056212

56,212

T2SS substrate NttA

NttA

Domain

93

false

This entry represents the type II secretion system substrate NttA from Legionella pneumophila and related proteins found mainly in Legionellales species. Homologues of NttA are also found outside Legionella genus. NttA contains and N-terminal disordered region followed by a globular all-α helical domain consisting of f...

[]

0

[ "PFAM" ]

[ "PF24275" ]

[ "NttA" ]

[ 93 ]

1

[]

0

[ "6xtt" ]

1

[ "PUB00155764" ]

[ "32656228" ]

[ "Structure, Dynamics and Cellular Insight Into Novel Substrates of the Legionella pneumophila Type II Secretion System." ]

[ 2020 ]

1

[]

0

null

[ "Pseudomonadati", "ecological metagenomes" ]

[ 91, 2 ]

2

[]

0

true

Domain

T2SS substrate NttA

NttA

8

IPR056213

56,213

T2SS substrate NttE-like

NttE-like

Family

86

false

This entry represents the type II secretion system substrate NttE from Legionella pneumophila ( ) and related proteins found mainly in Legionellales species. NttE structure is composed of two intertwined α/β domains, each of which consists of an antiparallel β-sheet and α-helices packed on it [ , ]. This protein forms ...

[]

0

[ "NCBIFAM", "PFAM", "CDD" ]

[ "NF037977", "PF24274", "cd21108" ]

[ "Lpg0189_fam", "NttE", "Lpg0189-like" ]

[ 84, 86, 69 ]

3

[]

0

[ "6l6g", "6l6h", "6skw" ]

3

[ "PUB00105497", "PUB00145672", "PUB00145673", "PUB00155764" ]

[ "31706575", "11727817", "31166887", "32656228" ]

[ "Crystal structure of a hypothetical T2SS effector Lpg0189 from Legionella pneumophila reveals a novel protein fold.", "Pathogenicity of Legionella pneumophila.", "Assessing the impact, genomics and evolution of type II secretion across a large, medically important genus: the Legionella type II secretion paradi...

[ 2020, 2001, 2019, 2020 ]

4

[]

0

null

[ "Legionellales" ]

[ 86 ]

1

[]

0

true

Family

T2SS substrate NttE-like

NttE-like

3

IPR056214

56,214

SrfA-like, pseudomonas

SrfA-like_pseudomonas

Family

24

false

This entry represents the Stress Response Facilitator A SrfA from Pseudomonas aeruginosa ( ) and similar sequences from Pseudomonas species. SrfA was shown to play a positive role in the sigma(22)-dependent activation of the algD promoter under stress in both sessile and planktonic conditions [ ]. This protein folds in...

[]

0

[ "PFAM" ]

[ "PF24296" ]

[ "SrfA" ]

[ 24 ]

1

[]

0

[ "7xnj" ]

1

[ "PUB00155848" ]

[ "25336469" ]

[ "Cell wall stress activates expression of a novel stress response facilitator (SrfA) under σ22 (AlgT/U) control in Pseudomonas aeruginosa." ]

[ 2015 ]

1

[]

0

null

[ "Pseudomonadaceae" ]

[ 24 ]

1

[]

0

true

Family

SrfA-like, pseudomonas

SrfA-like_pseudomonas

8

IPR056215

56,215

Anti-CRISPR Suppressor AcrIIA4-like

AcrIIA4-like

Family

44

false

This entry represents Anti-CRISPR Suppressor AcrIIA4 proteins encoded by Listeria monocytogenes prophages, including . AcrIIA4 preferentially targets critical residues essential for PAM duplex recognition, as well as it blocks target DNA access to the key catalytic residues lining the RuvC pocket of Cas9 [ ]. AcrIIA4 a...

[]

0

[ "NCBIFAM", "PFAM", "CDD" ]

[ "NF033946", "PF24304", "cd22281" ]

[ "AcrIIA4_fam", "AcrIIA4", "AcrllA4" ]

[ 44, 44, 28 ]

3

[]

0

[ "5vw1", "5vzl", "5xbl", "5xn4" ]

4

[ "PUB00146747", "PUB00147203", "PUB00147205", "PUB00147207", "PUB00147208", "PUB00147220" ]

[ "31021234", "29497118", "28602637", "29488867", "31207570", "26741979" ]

[ "Meet the Anti-CRISPRs: Widespread Protein Inhibitors of CRISPR-Cas Systems.", "Solution structure and dynamics of anti-CRISPR AcrIIA4, the Cas9 inhibitor.", "Inhibition Mechanism of an Anti-CRISPR Suppressor AcrIIA4 Targeting SpyCas9.", "Gene drive inhibition by the anti-CRISPR proteins AcrIIA2 and AcrIIA4 i...

[ 2019, 2018, 2017, 2018, 2019, 2016 ]

6

[]

0

null

[ "Listeria", "Viruses" ]

[ 11, 33 ]

2

[]

0

true

Family

Anti-CRISPR Suppressor AcrIIA4-like

AcrIIA4-like

4

IPR056217

56,217

THSD1, N-terminal domain

THSD1_N

Domain

1,006

false

This domain is found N-terminal in human Thrombospondin type-1 domain-containing protein 1 (THSD1) and similar proteins mainly found in vertebrates. THSD1 is involved in endothelial cell to extracellular matrix adhesion [ ]. THSD1 forms a multimeric protein complex with FAK/talin/vinculin, wherein THSD1 promotes talin ...

[]

0

[ "PFAM" ]

[ "PF24306" ]

[ "THSD1_N" ]

[ 1006 ]

1

[ "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-5083635", "R-HSA-5173214", "R-MMU-5173214" ]

[ "REACTOME:R-HSA-5083635", "REACTOME:R-HSA-5173214", "REACTOME:R-MMU-5173214" ]

3

[]

0

[ "PUB00043707", "PUB00088511", "PUB00155859" ]

[ "11687483", "27895300", "29069646" ]

[ "Thrombospondins: multifunctional regulators of cell interactions.", "THSD1 (Thrombospondin Type 1 Domain Containing Protein 1) Mutation in the Pathogenesis of Intracranial Aneurysm and Subarachnoid Hemorrhage.", "The Intracranial Aneurysm Gene THSD1 Connects Endosome Dynamics to Nascent Focal Adhesion Assembly...

[ 2001, 2016, 2017 ]

3

[]

0

null

[ "Bilateria" ]

[ 1006 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 2, 5, 5 ]

4

true

Domain

THSD1, N-terminal domain

THSD1_N

5

IPR056218

56,218

THSD1, second Ig-like domain

THSD1_D2

Domain

981

false

This domain is found in the human Thrombospondin type-1 domain-containing protein 1 (THSD1) and similar proteins mainly found in vertebrates. THSD1 is involved in endothelial cell to extracellular matrix adhesion [ ]. THSD1 forms a multimeric protein complex with FAK/talin/ vinculin, wherein THSD1 promotes talin bindin...

[]

0

[ "PFAM" ]

[ "PF24310" ]

[ "THSD1_D2" ]

[ 981 ]

1

[ "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-5083635", "R-HSA-5173214", "R-MMU-5173214" ]

[ "REACTOME:R-HSA-5083635", "REACTOME:R-HSA-5173214", "REACTOME:R-MMU-5173214" ]

3

[]

0

[ "PUB00043707", "PUB00088511", "PUB00155859" ]

[ "11687483", "27895300", "29069646" ]

[ "Thrombospondins: multifunctional regulators of cell interactions.", "THSD1 (Thrombospondin Type 1 Domain Containing Protein 1) Mutation in the Pathogenesis of Intracranial Aneurysm and Subarachnoid Hemorrhage.", "The Intracranial Aneurysm Gene THSD1 Connects Endosome Dynamics to Nascent Focal Adhesion Assembly...

[ 2001, 2016, 2017 ]

3

[]

0

null

[ "Gnathostomata" ]

[ 981 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 2, 5, 5 ]

4

true

Domain

THSD1, second Ig-like domain

THSD1_D2

6

IPR056219

56,219

THSD1, third Ig-like domain

THSD1_D3

Domain

1,058

false

This domain is found in the human Thrombospondin type-1 domain-containing protein 1 (THSD1) and similar proteins mainly found in vertebrates. THSD1 is involved in endothelial cell to extracellular matrix adhesion [ ]. THSD1 forms a multimeric protein complex with FAK/talin/ vinculin, wherein THSD1 promotes talin bindin...

[]

0

[ "PFAM" ]

[ "PF24311" ]

[ "THSD1_D3" ]

[ 1058 ]

1

[ "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-5083635", "R-HSA-5173214", "R-MMU-5173214" ]

[ "REACTOME:R-HSA-5083635", "REACTOME:R-HSA-5173214", "REACTOME:R-MMU-5173214" ]

3

[]

0

[ "PUB00043707", "PUB00088511", "PUB00155859" ]

[ "11687483", "27895300", "29069646" ]

[ "Thrombospondins: multifunctional regulators of cell interactions.", "THSD1 (Thrombospondin Type 1 Domain Containing Protein 1) Mutation in the Pathogenesis of Intracranial Aneurysm and Subarachnoid Hemorrhage.", "The Intracranial Aneurysm Gene THSD1 Connects Endosome Dynamics to Nascent Focal Adhesion Assembly...

[ 2001, 2016, 2017 ]

3

[]

0

null

[ "Eumetazoa" ]

[ 1058 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 2, 5, 5 ]

4

true

Domain

THSD1, third Ig-like domain

THSD1_D3

9

IPR056220

56,220

Paratox-like

Family

129

false

This entry represents the conserved mosaic prophage protein Paratox ( ) and related proteins from tailed bacteriophages and profagues from firmicutes. Paratox inhibits the natural competence regulator ComR and serves as a repressor of the competence regulon in vivo [ ]. This protein folds into an α/β structure consisti...

[]

0

[ "PFAM", "CDD" ]

[ "PF24313", "cd19959" ]

[ "Paratox", "paratox" ]

[ 129, 114 ]

2

[]

0

[ "6cka", "7n10", "7n1n", "8vsr" ]

4

[ "PUB00155781", "PUB00156998" ]

[ "30409983", "15866915" ]

[ "The conserved mosaic prophage protein paratox inhibits the natural competence regulator ComR in Streptococcus.", "Mosaic prophages with horizontally acquired genes account for the emergence and diversification of the globally disseminated M1T1 clone of Streptococcus pyogenes." ]

[ 2018, 2005 ]

2

[]

0

null

[ "Streptococcus" ]

[ 129 ]

1

[]

0

true

Family

Paratox-like

7

IPR056221

56,221

T6SS, Tle3 phospholipase effector, alpha/beta domain

Tle3_ab_dom

Domain

989

false

This entry represents a domain found at the N-terminal end of the type VI secretion system (T6SS) Tle3 phospholipase effector from adherent-invasive Escherichia coli and related proteobacterial proteins. Tle3 has a phospholipase A1 activity and its toxicity is neutralised by the cognate immunity protein Tli3. Tli3 and ...

[]

0

[ "PFAM" ]

[ "PF24322" ]

[ "Tle3" ]

[ 989 ]

1

[]

0

[ "8boz" ]

1

[ "PUB00155864" ]

[ "36675258" ]

[ "Activity and Crystal Structure of the Adherent-Invasive Escherichia coli Tle3/Tli3 T6SS Effector/Immunity Complex Determined Using an AlphaFold2 Predicted Model." ]

[ 2023 ]

1

[]

0

null

[ "Bacteria", "Dikarya", "Ralstonia phage RSY1", "marine sediment metagenome" ]

[ 984, 2, 1, 2 ]

4

[]

0

true

Domain

T6SS, Tle3 phospholipase effector, alpha/beta domain

Tle3_ab_dom

2

IPR056222

56,222

PH domain

PH_23

Domain

1,024

false

This domain is found in uncharacterised fungal proteins. It shares significant sequence similarity to known Pleckstrin homology domains (PH-domains) and it is predicted to adopt similar structure. Proteins containing this domain also contain a DH-domain located N-terminal to the PH-domain and are likely members of the ...

[]

0

[ "PFAM" ]

[ "PF24344" ]

[ "PH_23" ]

[ 1024 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Pezizomycotina" ]

[ 1024 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)" ]

[ 1 ]

1

true

Domain

PH domain

PH_23

4

IPR056224

56,224

FIGL1, N-terminal domain

FIGL1_N

Domain

559

false

This domain is found N-terminal in the ATPase family AAA domain-containing protein FIGL1 from Arabidopsis thaliana and similar plant proteins. FIGL1 is involved in DNA double-strand break repair via homologous recombination (HR). This protein Limits class II meiotic crossover formation by regulating the invasion step o...

[]

0

[ "PFAM" ]

[ "PF24347" ]

[ "FIGL1_N" ]

[ 559 ]

1

[]

0

[]

0

[ "PUB00110171" ]

[ "26161528" ]

[ "AAA-ATPase FIDGETIN-LIKE 1 and Helicase FANCM Antagonize Meiotic Crossovers by Distinct Mechanisms." ]

[ 2015 ]

1

[]

0

null

[ "Viridiplantae" ]

[ 559 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 5, 2, 8 ]

3

true

Domain

FIGL1, N-terminal domain

FIGL1_N

5

IPR056225

56,225

Neuron-derived neurotrophic factor, N-terminal domain

NDNF_N

Domain

1,466

false

This domain is found N-terminal in human Neuron-derived neurotrophic factor (NDNF) and similar animal proteins. NDNF is a secretory protein that plays a role in various cellular processes [ , ]. It acts as a chemorepellent on gonadotropin-releasing hormone expressing neurons regulating their migration to the hypothalam...

[]

0

[ "PFAM" ]

[ "PF24354" ]

[ "NDNF_N" ]

[ 1466 ]

1

[]

0

[]

0

[ "PUB00092492", "PUB00092493", "PUB00155755" ]

[ "24706764", "20969804", "31883645" ]

[ "Neuron-derived neurotrophic factor functions as a novel modulator that enhances endothelial cell function and revascularization processes.", "Spatio-temporal expression of a novel neuron-derived neurotrophic factor (NDNF) in mouse brains during development.", "Neuron-Derived Neurotrophic Factor Is Mutated in C...

[ 2014, 2010, 2020 ]

3

[]

0

null

[ "Bilateria" ]

[ 1466 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 2, 3, 1, 3 ]

5

true

Domain

Neuron-derived neurotrophic factor, N-terminal domain

NDNF_N

2

IPR056226

56,226

PARP12, winged helix domain

WH_PARP12

Domain

759

false

This domain is found at the N-terminal of human Protein mono-ADP-ribosyltransferase PARP12 and similar proteins from vertebrates. PARP12 is a mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins [ ]. The domain represented by this entry has a detectable sequence similarity to HTH winged he...

[]

0

[ "PFAM" ]

[ "PF24356" ]

[ "WHD_PARP12" ]

[ 759 ]

1

[]

0

[]

0

[ "PUB00146699" ]

[ "25043379" ]

[ "Family-wide analysis of poly(ADP-ribose) polymerase activity." ]

[ 2014 ]

1

[]

0

null

[ "Gnathostomata" ]

[ 759 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 3, 2, 3 ]

4

true

Domain

PARP12, winged helix domain

WH_PARP12

9

IPR056227

56,227

ABC transporter, TMD0 domain

TMD0_ABC

Domain

12,552

false

This transmembrane domain is found N-terminal in a number of ATP-binding cassette (ABC) transporters from animals and fungi. It is composed of four or five helices arranged in a bundle.

[]

0

[ "PFAM" ]

[ "PF24357" ]

[ "TMD0_ABC" ]

[ 12552 ]

1

[ "EC", "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME",...

[ "7.6.2", "7.6.2.3", "PWY-4061", "PWY-4621", "PWY-6842", "PWY-8259", "PWY-8301", "R-BTA-1660661", "R-BTA-189483", "R-BTA-2142691", "R-BTA-382556", "R-BTA-9707564", "R-BTA-9753281", "R-BTA-9758890", "R-CFA-1660661", "R-CFA-189483", "R-CFA-2142691", "R-CFA-382556", "R-CFA-9707564", ...

[ "EC:7.6.2", "EC:7.6.2.3", "METACYC:PWY-4061", "METACYC:PWY-4621", "METACYC:PWY-6842", "METACYC:PWY-8259", "METACYC:PWY-8301", "REACTOME:R-BTA-1660661", "REACTOME:R-BTA-189483", "REACTOME:R-BTA-2142691", "REACTOME:R-BTA-382556", "REACTOME:R-BTA-9707564", "REACTOME:R-BTA-9753281", "REACTOME:...

76

[ "6bhu", "6uy0", "7m68", "7m69", "7mpe", "8hvh", "8hw2", "8hw4", "8izp", "8izq", "8izr", "8jx7", "8jxq", "8jxu", "8jy4", "8jy5", "8rq3", "8rq4", "8sg4", "8sq0", "8sql", "8sqm", "8vt4", "8vux", "8vvc", "9ay0", "9ayc", "9br2", "9buk", "9c12", "9c2i", "9j9f"...

43

[]

0

[]

0

null

[ "Eukaryota" ]

[ 12552 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strai...

[ 8, 8, 18, 18, 11, 3, 18, 2, 1 ]

9

true

Domain

ABC transporter, TMD0 domain

TMD0_ABC

3

IPR056228

56,228

ABCC10-like, N-terminal domain

ABCC10-like_N

Domain

1,878

false

This domain is found N-terminal in the ABC transporter C family member 10 (ABCC10) from Arabidopsis thaliana and related proteins. ABCC10 is likely to pump for glutathione S-conjugates. This is a transmembrane domain whose function is unknown.

[]

0

[ "PFAM" ]

[ "PF24358" ]

[ "ABCC10_N" ]

[ 1878 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Embryophyta" ]

[ 1878 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 4, 5, 24 ]

3

true

Domain

ABCC10-like, N-terminal domain

ABCC10-like_N

4

IPR056229

56,229

TMEM62, Ig-like domain

Ig_TMM62

Domain

2,823

false

This domain is found in the human Transmembrane protein 62 (TMEM62), uncharacterised At3g03305 protein from Arabidopsis thaliana and related eukaryotic proteins. TMEM62 has been identified as a potential therapeutic target to enhance survival from high-grade serous carcinomas [ ]. The domain represented by this entry i...

[]

0

[ "PFAM" ]

[ "PF24384" ]

[ "Ig_TMM62" ]

[ 2823 ]

1

[]

0

[]

0

[ "PUB00155678" ]

[ "37958473" ]

[ "Aptamers as Potential Therapeutic Tools for Ovarian Cancer: Advancements and Challenges." ]

[ 2023 ]

1

[]

0

null

[ "Eukaryota", "Thermodesulfobacteriota" ]

[ 2821, 2 ]

2

[ "Arabidopsis thaliana", "Danio rerio", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 4, 4, 2, 2, 9, 2, 8 ]

7

true

Domain

TMEM62, Ig-like domain

Ig_TMM62

1

IPR056230

56,230

TMEM62, C-terminal domain

TMEM62_C

Domain

2,583

false

This domain is found C-terminal in the human Transmembrane protein 62 (TMEM62), the uncharacterised At3g03305 protein from Arabidopsis thaliana and related eukaryotic proteins. TMEM62 has been identified as a potential therapeutic target to enhance survival from high-grade serous carcinomas [ ]. The domain represented ...

[]

0

[ "PFAM" ]

[ "PF24394" ]

[ "TMEM62_C" ]

[ 2583 ]

1

[]

0

[]

0

[ "PUB00155678" ]

[ "37958473" ]

[ "Aptamers as Potential Therapeutic Tools for Ovarian Cancer: Advancements and Challenges." ]

[ 2023 ]

1

[]

0

null

[ "Bacteria", "Eukaryota" ]

[ 8, 2575 ]

2

[ "Arabidopsis thaliana", "Danio rerio", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Zea mays" ]

[ 4, 4, 2, 2, 8, 1, 1, 8 ]

8

true

Domain

TMEM62, C-terminal domain

TMEM62_C

8

IPR056231

56,231

VNG_1110C-like

Family

275

false

This entry represents a family of archaeal uncharacterised proteins, including VNG_1110C protein from Halobacterium salinarum. These proteins are predicted to adopt a globular structure consisting of three-stranded antiparallel β-sheet and two α-helices packed on one side of the sheet. They contain two semi-conserved R...

[]

0

[ "PFAM" ]

[ "PF24397" ]

[ "VNG_1110C" ]

[ 275 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Halobacteriales" ]

[ 275 ]

1

[]

0

true

Family

VNG_1110C-like

3

IPR056232

56,232

Nuclear pore complex protein GP210, Ig-like domain 15

Ig_GP210_15th

Domain

623

false

This domain is found in the Nuclear pore complex protein GP210 from Arabidopsis thaliana and related plant proteins. GP210 is predicted to contain 16 Ig-like domains. This entry represents the 15th of these domains.

[]

0

[ "PFAM" ]

[ "PF24425" ]

[ "Ig_GP210_15th" ]

[ 623 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Eukaryota" ]

[ 623 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 5, 3, 7 ]

3

true

Domain

Nuclear pore complex protein GP210, Ig-like domain 15

Ig_GP210_15th

1

IPR056233

56,233

Nuclear pore complex protein GP210, C-terminal Ig-like domain

Ig_GP210_16th

Domain

589

false

This domain is found in the Nuclear pore complex protein GP210 from Arabidopsis thaliana and related plant proteins. GP210 is predicted to contain 16 Ig-like domains. This entry represents the 16th of these domains.

[]

0

[ "PFAM" ]

[ "PF24427" ]

[ "Ig_GP210_16th" ]

[ 589 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Viridiplantae" ]

[ 589 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 4, 3, 6 ]

3

true

Domain

Nuclear pore complex protein GP210, C-terminal Ig-like domain

Ig_GP210_16th

4

IPR056234

56,234

NFXL1, RRM-like domain

RRM_NFXL1

Domain

677

false

This domain is found in NF-X1-type zinc finger protein NFXL1 from Arabidopsis thaliana and related plant proteins. AtNFXL1, a homologue of the human transcription repressor NF-X1, plays an important role in the trichothecene response, as well as the general defence response in Arabidopsis [ ]. This domain has a detecta...

[]

0

[ "PFAM" ]

[ "PF24435" ]

[ "RRM_NFXL1" ]

[ 677 ]

1

[]

0

[]

0

[ "PUB00120752" ]

[ "18069941" ]

[ "AtNFXL1, an Arabidopsis homologue of the human transcription factor NF-X1, functions as a negative regulator of the trichothecene phytotoxin-induced defense response." ]

[ 2008 ]

1

[]

0

null

[ "Eukaryota" ]

[ 677 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 5, 6, 6 ]

3

true

Domain

NFXL1, RRM-like domain

RRM_NFXL1

5

IPR056235

56,235

INTS4, 8 helical bundle domain

INTS4_8HBD

Domain

1,561

false

This domain is found in human Integrator complex subunit 4 (INTS4) and its animal homologues. The domain represented by this entry makes extensive contacts with INTS7 and stabilise the beta-CASP domain of INTS9 in the cleavage module [ , ]. It folds into an eight α-helical bundle. INTS4 is a component of the Integrator...

[]

0

[ "PFAM" ]

[ "PF24493" ]

[ "INTS4_8HBD" ]

[ 1561 ]

1

[ "REACTOME", "REACTOME", "REACTOME" ]

[ "R-DME-6807505", "R-HSA-6807505", "R-MMU-6807505" ]

[ "REACTOME:R-DME-6807505", "REACTOME:R-HSA-6807505", "REACTOME:R-MMU-6807505" ]

3

[ "7bfp", "7bfq", "7cun", "7pks", "7sn8", "7ycx", "8r2d", "8rbx", "8rbz", "8rc4", "8yjb", "9vd9" ]

12

[ "PUB00151776", "PUB00152015", "PUB00155682", "PUB00160477" ]

[ "33548203", "33243860", "38570683", "29471365" ]

[ "Structure of the catalytic core of the Integrator complex.", "Identification of Integrator-PP2A complex (INTAC), an RNA polymerase II phosphatase.", "Structural basis of Integrator-dependent RNA polymerase II termination.", "Integrator subunit 4 is a 'Symplekin-like' scaffold that associates with INTS9/11 to...

[ 2021, 2020, 2024, 2018 ]

4

[]

0

null

[ "Eukaryota" ]

[ 1561 ]

1

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 1, 12, 1, 8 ]

5

true

Domain

INTS4, 8 helical bundle domain

INTS4_8HBD

2

IPR056236

56,236

PCA1, HMA heavy metal-associated domain

HMA_PCA1

Domain

1,286

false

This domain is found in the yeast P-type cation-transporting ATPase (PCA1) and similar fungal proteins. PCA1 is a cadmium transporting P-type ATPase which plays a critical role in cadmium resistance by extruding intracellular cadmium [ , ]. This domain has a detectable similarity to heavy-metal-binding domains and it i...

[]

0

[ "PFAM" ]

[ "PF24534" ]

[ "HMA_PCA1" ]

[ 1286 ]

1

[]

0

[]

0

[ "PUB00155661", "PUB00155662" ]

[ "10743563", "17107946" ]

[ "The cadmium-resistant gene, CAD2, which is a mutated putative copper-transporter gene (PCA1), controls the intracellular cadmium-level in the yeast S. cerevisiae.", "A cadmium-transporting P1B-type ATPase in yeast Saccharomyces cerevisiae." ]

[ 2000, 2007 ]

2

[]

0

null

[ "Eukaryota" ]

[ 1286 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)" ]

[ 1, 1 ]

2

true

Domain

PCA1, HMA heavy metal-associated domain

HMA_PCA1

5

IPR056237

56,237

ANKLE2, third alpha/beta domain

ANKLE2_3rd

Domain

1,810

false

This domain is found in the human Ankyrin repeat and LEM domain-containing protein 2 (ANKLE2) and related proteins. Human ANKLE2 is involved in mitotic nuclear envelope reassembly by promoting dephosphorylation of BAF/BANF1 during mitotic exit [ ]. The domain represented by this entry is predicted to adopt a globular α...

[]

0

[ "PFAM" ]

[ "PF24567" ]

[ "ANKLE2_3rd" ]

[ 1810 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-CEL-2995383", "R-DME-2995383", "R-HSA-2995383", "R-HSA-9013404", "R-HSA-9013408", "R-MMU-2995383", "R-MMU-9013404", "R-MMU-9013408", "R-RNO-2995383", "R-RNO-9013404", "R-RNO-9013408" ]

[ "REACTOME:R-CEL-2995383", "REACTOME:R-DME-2995383", "REACTOME:R-HSA-2995383", "REACTOME:R-HSA-9013404", "REACTOME:R-HSA-9013408", "REACTOME:R-MMU-2995383", "REACTOME:R-MMU-9013404", "REACTOME:R-MMU-9013408", "REACTOME:R-RNO-2995383", "REACTOME:R-RNO-9013404", "REACTOME:R-RNO-9013408" ]

11

[]

0

[ "PUB00084828" ]

[ "22770216" ]

[ "Coordination of kinase and phosphatase activities by Lem4 enables nuclear envelope reassembly during mitosis." ]

[ 2012 ]

1

[]

0

null

[ "Metazoa" ]

[ 1810 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 9, 1, 2, 1, 5 ]

6

true

Domain

ANKLE2, third alpha/beta domain

ANKLE2_3rd

7

IPR056238

56,238

YunG-like

Family

1,191

false

This entry represents the uncharacterised Bacillus subtilis YunG protein and its homologues. Members of this entry contain a potential catalytic triad composed of Cys, His and Asp residues.

[]

0

[ "PFAM" ]

[ "PF24585" ]

[ "YunG" ]

[ 1191 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Cuauhnahuacvirus", "Eukaryota", "ecological metagenomes" ]

[ 5, 1173, 2, 4, 7 ]

5

[]

0

true

Family

YunG-like

1

IPR056239

56,239

Phage YunG-like

Phage_YunG-like

Family

101

false

This entry represents a small family of uncharacterised phage and prophage proteins. These proteins show structural similarity to the B. subtilis YunG protein and appear to conserve a putative catalytic triad of cys, his and asp. Structure predictions suggest that these proteins may form homodimers.

[]

0

[ "PFAM" ]

[ "PF24591" ]

[ "Phage_YunG-like" ]

[ 101 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Candidatus Methanofastidiosum methylothiophilum", "Caudoviricetes", "marine sediment metagenome" ]

[ 26, 1, 73, 1 ]

4

[]

0

true

Family

Phage YunG-like

Phage_YunG-like

7

IPR056241

56,241

E3 ubiquitin-protein ligase listerin, HEAT-repeats region

LTN1_HEAT_5th

Domain

913

false

This entry represents a putative HEAT repeats region from the LTN1 family of proteins. The LTN1 family consists of E3 ubiquitin-protein ligases that are integral components of the ribosome quality control complex (RQC) [ , , ]. The RQC is a ribosome-associated complex responsible for the ubiquitination and subsequent e...

[]

0

[ "PFAM" ]

[ "PF24618" ]

[ "LTN1_E3_ligase_5th" ]

[ 913 ]

1

[ "EC", "METACYC", "REACTOME", "REACTOME", "REACTOME" ]

[ "2.3.2.27", "PWY-7511", "R-CEL-983168", "R-HSA-983168", "R-MMU-983168" ]

[ "EC:2.3.2.27", "METACYC:PWY-7511", "REACTOME:R-CEL-983168", "REACTOME:R-HSA-983168", "REACTOME:R-MMU-983168" ]

5

[ "3j92", "9gy4" ]

2

[ "PUB00090130", "PUB00155724", "PUB00155725" ]

[ "25132172", "23685075", "28757607" ]

[ "Reconstitution of a minimal ribosome-associated ubiquitination pathway with purified factors.", "Listerin-dependent nascent protein ubiquitination relies on ribosome subunit dissociation.", "Ubiquitination of stalled ribosome triggers ribosome-associated quality control." ]

[ 2014, 2013, 2017 ]

3

[]

0

null

[ "Metazoa" ]

[ 913 ]

1

[ "Caenorhabditis elegans", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 1, 1, 2 ]

4

true

Domain

E3 ubiquitin-protein ligase listerin, HEAT-repeats region

LTN1_HEAT_5th

6

IPR056242

56,242

TASOR, PIN domain

PIN_TASOR

Domain

2,601

false

This is a domain found in TASOR proteins, a key component of the HUSH complex, a vertebrate-specific multiprotein complex that mediates epigenetic repression of both exogenous and endogenous genetic elements [ , , ]. The HUSH complex regulates H3K9me3 deposition by promoting recruitment of SETDB1 and also recruits MORC...

[]

0

[ "PFAM" ]

[ "PF24630" ]

[ "PIN_TASOR" ]

[ 2601 ]

1

[ "REACTOME" ]

[ "R-HSA-9843970" ]

[ "REACTOME:R-HSA-9843970" ]

1

[]

0

[ "PUB00087337", "PUB00100823", "PUB00100826", "PUB00100827" ]

[ "26022416", "28581500", "33009411", "28839193" ]

[ "GENE SILENCING. Epigenetic silencing by the HUSH complex mediates position-effect variegation in human cells.", "Hyperactivation of HUSH complex function by Charcot-Marie-Tooth disease mutation in MORC2.", "TASOR is a pseudo-PARP that directs HUSH complex assembly and epigenetic transposon control.", "The ep...

[ 2015, 2017, 2020, 2017 ]

4

[]

0

null

[ "Eumetazoa", "bird metagenome" ]

[ 2600, 1 ]

2

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 7, 10, 4, 8 ]

4

true

Domain

TASOR, PIN domain

PIN_TASOR

5

IPR056244

56,244

DEAH11/12, RRM domain

RRM_DEAH11/12

Domain

767

false

This RNA recognition motif (RRM) containing domain is found in the ATP-dependent RNA helicase DEAH11, DEAH12 from Arabidopsis thaliana and related plant proteins. This domain shares detectable similarity to RNA binding domains and is predicted to adopt an α/β structure with similar topology.

[]

0

[ "PFAM" ]

[ "PF24637" ]

[ "RRM_DEAH11" ]

[ 767 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Eukaryota" ]

[ 767 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 8, 3, 8 ]

3

true

Domain

DEAH11/12, RRM domain

RRM_DEAH11/12

1

IPR056245

56,245

DEAH11/12, KH-domain

KH_DEAH11/12

Domain

965

false

This presumed KH domain is found in ATP-dependent RNA helicase DEAH11 and DEAH12 from Arabidopsis thaliana and similar sequences from plants and animals. Its specific function is unknown.

[]

0

[ "PFAM" ]

[ "PF24471" ]

[ "KH_DEAH11" ]

[ 965 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Eukaryota" ]

[ 965 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 8, 4, 6 ]

3

true

Domain

DEAH11/12, KH-domain

KH_DEAH11/12

7

IPR056246

56,246

DEAH11/12, type I KH-domain

KH_DEAH11/12_1st

Domain

810

false

This domain is found in the ATP-dependent RNA helicase DEAH11 and DEAH12 from Arabidopsis thaliana and related plant proteins. This domain shares detectable similarity to type I KH domains and is predicted to adopt an α/β structure with similar topology.

[]

0

[ "PFAM" ]

[ "PF24638" ]

[ "KH_DEAH11_1st" ]

[ 810 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Embryophyta" ]

[ 810 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 8, 4, 7 ]

3

true

Domain

DEAH11/12, type I KH-domain

KH_DEAH11/12_1st

3

IPR056247

56,247

DEAH11/12, second type I KH-domain

KH_DEAH11/12_2nd

Domain

871

false

This domain is found in the ATP-dependent RNA helicase DEAH11 and DEAH12 from Arabidopsis thaliana and related plant proteins. This domain shares detectable similarity to type I KH domains and is predicted to adopt an α/β structure with similar topology.

[]

0

[ "PFAM" ]

[ "PF24641" ]

[ "KH_DEAH11_2nd" ]

[ 871 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Eukaryota" ]

[ 871 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 8, 4, 7 ]

3

true

Domain

DEAH11/12, second type I KH-domain

KH_DEAH11/12_2nd

6

IPR056248

56,248

DEAH11/12, RNA-binding domain

RBD_DEAH11/12

Domain

838

false

This presumed RNA binding domain (RBD) is found in ATP-dependent RNA helicase DEAH11 and DEAH12 from Arabidopsis thaliana and similar sequences from plants. Its specific function is unknown.

[]

0

[ "PFAM" ]

[ "PF24475" ]

[ "RBD_DEAH11" ]

[ 838 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Eukaryota" ]

[ 838 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 8, 3, 8 ]

3

true

Domain

DEAH11/12, RNA-binding domain

RBD_DEAH11/12

2

IPR056250

56,250

Archaeo-eukaryotic primase 1D-like

AEP-like

Family

83

false

This entry represents a nucleotidyltransferase of the archaeo-eukaryotic primase superfamily predicted to produce an oligo/cyclic nucleotide signal that activates the associated effectors in the associated prokaryotic antiviral immunity system. These proteins feature a single aspartate in the DXD active site [ ].

[]

0

[ "PFAM" ]

[ "PF24387" ]

[ "AEP-like" ]

[ 83 ]

1

[]

0

[]

0

[ "PUB00155486" ]

[ "37889040" ]

[ "Functionally comparable but evolutionarily distinct nucleotide-targeting effectors help identify conserved paradigms across diverse immune systems." ]

[ 2023 ]

1

[]

0

null

[ "Bacteria", "metagenomes" ]

[ 81, 2 ]

2

[]

0

true

Family

Archaeo-eukaryotic primase 1D-like

AEP-like

1

IPR056251

56,251

Arm-like repeat domain

Arm_rpt_dom

Domain

1,001

false

This entry represents a region of α-solenoid repeats found in a group of fungal proteins. This domain is sometimes found at the N-terminal end of the proteins followed by a NACHT domain .

[]

0

[ "PFAM" ]

[ "PF23948" ]

[ "ARM_5" ]

[ 1001 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Fungi", "Mycoavidus cysteinexigens" ]

[ 976, 25 ]

2

[]

0

true

Domain

Arm-like repeat domain

Arm_rpt_dom

4

IPR056252

56,252

Alfy-like, armadillo-like repeat domain

Alfy-like_Arm-like

Domain

4,106

false

This entry represents a region of armadillo-like repeats found in human WD repeat and FYVE domain-containing protein 3 (WDFY3, also known as Alfy) and similar eukaryotic sequences. Alfy is required for selective macroautophagy (aggrephagy) [ ]. It is important for normal brain development [ , ]. This domain is also fou...

[]

0

[ "PFAM" ]

[ "PF23295" ]

[ "Arm_4" ]

[ 4106 ]

1

[]

0

[]

0

[ "PUB00054042", "PUB00155995", "PUB00155996", "PUB00155997", "PUB00155998" ]

[ "20417604", "25198012", "27648578", "10588668", "19392685" ]

[ "The selective macroautophagic degradation of aggregated proteins requires the PI3P-binding protein Alfy.", "Loss of Wdfy3 in mice alters cerebral cortical neurogenesis reflecting aspects of the autism pathology.", "Autophagy linked FYVE (Alfy/WDFY3) is required for establishing neuronal connectivity in the mam...

[ 2010, 2014, 2016, 1999, 2009 ]

5

[]

0

null

[ "Eukaryota" ]

[ 4106 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus" ]

[ 14, 4, 40, 1, 2, 3, 1, 7 ]

8

true

Domain

Alfy-like, armadillo-like repeat domain

Alfy-like_Arm-like

6

IPR056253

56,253

At2g29880-like, C-terminal domain

At2g29880-like_C

Domain

1,131

false

This domain is found C-terminal in Uncharacterized protein At2g29880 from Arabidopsis thaliana and related plant proteins. Some proteins containing this domain have also a Myb/SANT-like domain ( ) at the N terminus. The function of this domain is unknown.

[]

0

[ "PFAM" ]

[ "PF24769" ]

[ "At2g29880_C" ]

[ 1131 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Magnoliopsida" ]

[ 1131 ]

1

[ "Arabidopsis thaliana" ]

[ 23 ]

1

true

Domain

At2g29880-like, C-terminal domain

At2g29880-like_C

4

IPR056254

56,254

At5g58720/SDE5-like, UBA-like domain

At5g58720/SDE5-like_UBA-like

Domain

1,275

false

This domain is found towards the N-terminal of SMR domain-containing protein At5g58720, Putative nuclear RNA export factor SDE5 from Arabidopsis thaliana and similar plant proteins. SDE5 is involved in sense transgene post-transcriptional gene silencing [ ]. This domain has detectable similarity to UBA domains, particu...

[]

0

[ "PFAM" ]

[ "PF24767" ]

[ "UBA_At5g58720" ]

[ 1275 ]

1

[]

0

[]

0

[ "PUB00155897" ]

[ "17397509" ]

[ "SDE5, the putative homologue of a human mRNA export factor, is required for transgene silencing and accumulation of trans-acting endogenous siRNA." ]

[ 2007 ]

1

[]

0

null

[ "Eukaryota", "Methanothermobacter wolfeii" ]

[ 1274, 1 ]

2

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 12, 5, 14 ]

3

true

Domain

At5g58720/SDE5-like, UBA-like domain

At5g58720/SDE5-like_UBA-like

6

IPR056255

56,255

Cartilage intermediate layer protein 1/2 domain

CILP-1/2_dom

Domain

1,839

false

This domain is found in human human Cartilage intermediate layer protein 1/2 (CILP-1/2) and similar sequences mainly found in vertebrates. It is predicted to adopt an all-β structure and is often found immediately C-terminal to . CILP-1 is thought to play a role in cartilage scaffolding. CLIP-1 may act by antagonising ...

[]

0

[ "PFAM" ]

[ "PF23708" ]

[ "CILP_5th" ]

[ 1839 ]

1

[ "REACTOME", "REACTOME" ]

[ "R-HSA-2404192", "R-MMU-2404192" ]

[ "REACTOME:R-HSA-2404192", "REACTOME:R-MMU-2404192" ]

2

[]

0

[ "PUB00089953", "PUB00089955", "PUB00155999" ]

[ "15864306", "21880736", "12746903" ]

[ "A functional SNP in CILP, encoding cartilage intermediate layer protein, is associated with susceptibility to lumbar disc disease.", "Cartilage intermediate layer protein 2 (CILP-2) is expressed in articular and meniscal cartilage and down-regulated in experimental osteoarthritis.", "One of two chondrocyte-exp...

[ 2005, 2011, 2003 ]

3

[]

0

null

[ "Eumetazoa" ]

[ 1839 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 4, 3, 5 ]

4

true

Domain

Cartilage intermediate layer protein 1/2 domain

CILP-1/2_dom

4

IPR056256

56,256

Cartilage intermediate layer protein 1/2, beta-sandwich domain 2

CILP-1/2_b-sand_dom2

Domain

1,828

false

This domain is found in human human Cartilage intermediate layer protein 1/2 (CILP-1/2) and similar sequences mainly found in vertebrates. It is predicted to show a seven stranded β-sandwich fold. CILP-1 is thought to play a role in cartilage scaffolding. CLIP-1 may act by antagonising TGF-beta1 (TGFB1) and IGF1 functi...

[]

0

[ "PFAM" ]

[ "PF23591" ]

[ "CILP" ]

[ 1828 ]

1

[ "REACTOME", "REACTOME" ]

[ "R-HSA-2404192", "R-MMU-2404192" ]

[ "REACTOME:R-HSA-2404192", "REACTOME:R-MMU-2404192" ]

2

[]

0

[ "PUB00089953", "PUB00089955", "PUB00155999" ]

[ "15864306", "21880736", "12746903" ]

[ "A functional SNP in CILP, encoding cartilage intermediate layer protein, is associated with susceptibility to lumbar disc disease.", "Cartilage intermediate layer protein 2 (CILP-2) is expressed in articular and meniscal cartilage and down-regulated in experimental osteoarthritis.", "One of two chondrocyte-exp...

[ 2005, 2011, 2003 ]

3

[]

0

null

[ "Eumetazoa", "Kangiella spongicola" ]

[ 1827, 1 ]

2

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 4, 3, 5 ]

4

true

Domain

Cartilage intermediate layer protein 1/2, beta-sandwich domain 2

CILP-1/2_b-sand_dom2

5

IPR056257

56,257

Cartilage intermediate layer protein 1/2, beta-sandwich domain

CILP-1/2_8th

Domain

2,172

false

This domain is found in human Cartilage intermediate layer protein 1/2 (CILP-1/2) and similar sequences mainly found in vertebrates. CILP-1 is thought to play a role in cartilage scaffolding. CLIP-1 may act by antagonising TGF-beta1 (TGFB1) and IGF1 functions. It can suppress IGF1-induced proliferation and sulfated pro...

[]

0

[ "PFAM" ]

[ "PF23730" ]

[ "CILP_8th" ]

[ 2172 ]

1

[ "REACTOME", "REACTOME" ]

[ "R-HSA-2404192", "R-MMU-2404192" ]

[ "REACTOME:R-HSA-2404192", "REACTOME:R-MMU-2404192" ]

2

[]

0

[ "PUB00089953", "PUB00089955", "PUB00155999" ]

[ "15864306", "21880736", "12746903" ]

[ "A functional SNP in CILP, encoding cartilage intermediate layer protein, is associated with susceptibility to lumbar disc disease.", "Cartilage intermediate layer protein 2 (CILP-2) is expressed in articular and meniscal cartilage and down-regulated in experimental osteoarthritis.", "One of two chondrocyte-exp...

[ 2005, 2011, 2003 ]

3

[]

0

null

[ "Bilateria", "Kangiella spongicola" ]

[ 2171, 1 ]

2

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 4, 3, 5 ]

4

true

Domain

Cartilage intermediate layer protein 1/2, beta-sandwich domain

CILP-1/2_8th

6

IPR056258

56,258

Cartilage intermediate layer protein 1/2, C-terminal

CILP-1/2_C

Domain

1,827

false

This domain is found at the C-terminal of human Cartilage intermediate layer protein 1/2 (CILP-1/2) and similar sequences mainly found in vertebrates. It may adopt a β-sandwich fold. CILP-1 is thought to play a role in cartilage scaffolding. CLIP-1 may act by antagonising TGF-beta1 (TGFB1) and IGF1 functions. It can su...

[]

0

[ "PFAM" ]

[ "PF23599" ]

[ "CILP_C" ]

[ 1827 ]

1

[ "REACTOME", "REACTOME" ]

[ "R-HSA-2404192", "R-MMU-2404192" ]

[ "REACTOME:R-HSA-2404192", "REACTOME:R-MMU-2404192" ]

2

[]

0

[ "PUB00089953", "PUB00089955", "PUB00155999" ]

[ "15864306", "21880736", "12746903" ]

[ "A functional SNP in CILP, encoding cartilage intermediate layer protein, is associated with susceptibility to lumbar disc disease.", "Cartilage intermediate layer protein 2 (CILP-2) is expressed in articular and meniscal cartilage and down-regulated in experimental osteoarthritis.", "One of two chondrocyte-exp...

[ 2005, 2011, 2003 ]

3

[]

0

null

[ "Eumetazoa", "Kangiella spongicola" ]

[ 1826, 1 ]

2

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 4, 3, 5 ]

4

true

Domain

Cartilage intermediate layer protein 1/2, C-terminal

CILP-1/2_C

7

IPR056259

56,259

Caspase-8, N-terminal domain

Dredd_N

Domain

354

false

This domain is found at the N-terminal of Caspase-8 from Drosophila melanogaster (Dredd) and similar proteins mainly found in insects. Dredd is an effector of the programmed cell death (PCD) activators rpr, grim and hid [ ]. It plays a role in the innate immune response and may be involved in apoptosis in the germline ...

[]

0

[ "PFAM" ]

[ "PF23725" ]

[ "Dredd_N" ]

[ 354 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-DME-111458", "R-DME-111459", "R-DME-198323", "R-DME-214397", "R-DME-214399", "R-DME-214411", "R-DME-214416", "R-DME-5357905", "R-DME-6803207", "R-DME-9627069" ]

[ "REACTOME:R-DME-111458", "REACTOME:R-DME-111459", "REACTOME:R-DME-198323", "REACTOME:R-DME-214397", "REACTOME:R-DME-214399", "REACTOME:R-DME-214411", "REACTOME:R-DME-214416", "REACTOME:R-DME-5357905", "REACTOME:R-DME-6803207", "REACTOME:R-DME-9627069" ]

10

[]

0

[ "PUB00156000", "PUB00156001", "PUB00156002" ]

[ "10934188", "11269502", "9740659" ]

[ "dFADD, a novel death domain-containing adapter protein for the Drosophila caspase DREDD.", "The Drosophila caspase Dredd is required to resist gram-negative bacterial infection.", "Dredd, a novel effector of the apoptosis activators reaper, grim, and hid in Drosophila." ]

[ 2000, 2000, 1998 ]

3

[]

0

null

[ "Pancrustacea" ]

[ 354 ]

1

[ "Drosophila melanogaster" ]

[ 9 ]

1

true

Domain

Caspase-8, N-terminal domain

Dredd_N

8

IPR056261

56,261

1,3-beta-glucan synthase component FKS1-like, domain-2

FKS1-like_dom2

Domain

2,556

false

This domain is found in 1,3-beta-glucan synthase component FKS1 from Saccharomyces cerevisiae and similar fungal proteins. FKS1 is involved in cell wall synthesis, maintenance and remodelling. This domain is predicted to adopt an all-α structure [ ]. This domain is often found between and .

[]

0

[ "PFAM" ]

[ "PF23605" ]

[ "FKS1_dom2" ]

[ 2556 ]

1

[ "EC", "METACYC" ]

[ "2.4.1.34", "PWY-6773" ]

[ "EC:2.4.1.34", "METACYC:PWY-6773" ]

2

[ "7xe4", "7yuy", "8jzn", "8wl6", "8wla" ]

5

[ "PUB00156003" ]

[ "11856368" ]

[ "Movement of yeast 1,3-beta-glucan synthase is essential for uniform cell wall synthesis." ]

[ 2002 ]

1

[]

0

null

[ "Opisthokonta" ]

[ 2556 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 3, 4 ]

3

true

Domain

1,3-beta-glucan synthase component FKS1-like, domain-2

FKS1-like_dom2

9

IPR056262

56,262

16S rRNA (adenine(1408)-N(1))-methyltransferase

NpmA

Family

131

false

This entry represents the 16S rRNA (adenine(1408)-N(1))-methyltransferase from Escherichia coli (NPMA) and similar bacterial proteins. NPMA specifically methylates the N1 position of adenine 1408 in 16S rRNA and confers resistance to various aminoglycosides, including kanamycin, neomycin, apramycin, ribostamycin and ge...

[]

0

[ "PFAM" ]

[ "PF24675" ]

[ "NpmA" ]

[ 131 ]

1

[ "EC" ]

[ "2.1.1.180" ]

[ "EC:2.1.1.180" ]

1

[ "3mq2", "3mte", "3p2e", "3p2i", "3p2k", "3pb3", "4ox9", "4rwz", "4rx1", "4x1o", "5bw4", "5bw5", "5d1h", "5d1n", "7ehf", "7jlz" ]

16

[ "PUB00055786", "PUB00156004", "PUB00156005", "PUB00156006" ]

[ "21062819", "17875999", "20667473", "24717845" ]

[ "Structural basis for the methylation of A1408 in 16S rRNA by a panaminoglycoside resistance methyltransferase NpmA from a clinical isolate and analysis of the NpmA interactions with the 30S ribosomal subunit.", "Novel plasmid-mediated 16S rRNA m1A1408 methyltransferase, NpmA, found in a clinically isolated Esche...

[ 2011, 2007, 2011, 2014 ]

4

[]

0

null

[ "Bacteria" ]

[ 131 ]

1

[]

0

true

Family

16S rRNA (adenine(1408)-N(1))-methyltransferase

NpmA

8

IPR056263

56,263

26S proteasome regulatory subunit RPN11, C-terminal domain

RPN11_C

Domain

5,572

false

This entry represents the C-terminal helical domain of Ubiquitin carboxyl-terminal hydrolase RPN11 from Saccharomyces cerevisiae, its animal homologue 26S proteasome non-ATPase regulatory subunit 14 (also named RPN11) and similar eukaryotic 26S proteosomal subunits. This region is involved in forming a helical bundle w...

[]

0

[ "PFAM" ]

[ "PF23594" ]

[ "RPN11_C" ]

[ 5572 ]

1

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", ...

[ "3.4.19", "R-CEL-1234176", "R-CEL-1236978", "R-CEL-187577", "R-CEL-195253", "R-CEL-349425", "R-CEL-350562", "R-CEL-382556", "R-CEL-4608870", "R-CEL-4641258", "R-CEL-5632684", "R-CEL-5687128", "R-CEL-5689603", "R-CEL-5689880", "R-CEL-5689901", "R-CEL-6798695", "R-CEL-68949", "R-CEL-...

[ "EC:3.4.19", "REACTOME:R-CEL-1234176", "REACTOME:R-CEL-1236978", "REACTOME:R-CEL-187577", "REACTOME:R-CEL-195253", "REACTOME:R-CEL-349425", "REACTOME:R-CEL-350562", "REACTOME:R-CEL-382556", "REACTOME:R-CEL-4608870", "REACTOME:R-CEL-4641258", "REACTOME:R-CEL-5632684", "REACTOME:R-CEL-5687128", ...

257

[ "3j47", "3jck", "3jco", "3jcp", "4cr2", "4cr3", "4cr4", "5a5b", "5gjq", "5gjr", "5l4k", "5ln3", "5m32", "5mpb", "5mpc", "5mpd", "5mpe", "5t0c", "5t0g", "5t0h", "5t0i", "5t0j", "5vfp", "5vfq", "5vfr", "5vfs", "5vft", "5vfu", "5vgz", "5vhf", "5vhh", "5vhi"...

114

[ "PUB00091255", "PUB00091262", "PUB00091263", "PUB00152659" ]

[ "27791164", "23911091", "24706844", "26744777" ]

[ "Structural basis for dynamic regulation of the human 26S proteasome.", "Formation of an intricate helical bundle dictates the assembly of the 26S proteasome lid.", "Deep classification of a large cryo-EM dataset defines the conformational landscape of the 26S proteasome.", "Atomic structure of the 26S protea...

[ 2016, 2013, 2014, 2016 ]

4

[]

0

null

[ "Eukaryota" ]

[ 5572 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 3, 1, 1, 1, 5, 3, 1, 7, 3, 1, 1, 21 ]

12

true

Domain

26S proteasome regulatory subunit RPN11, C-terminal domain

RPN11_C

9

IPR056264

56,264

ABCA1-4-like, C-terminal R2 regulatory domain

R2_ABCA1-4-like

Domain

16,548

false

This domain is found at the C-terminal of human Phospholipid-transporting ATPases ABCA1-4 and similar sequences predominantly found in animals, which are lipid transporters. ABCA1 catalyses the translocation of specific phospholipids from the cytoplasmic to the extracellular/lumenal leaflet of membrane coupled to the h...

[]

0

[ "PFAM" ]

[ "PF23321" ]

[ "R1_ABCA1" ]

[ 16548 ]

1

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", ...

[ "7.6.2", "R-BTA-2453902", "R-BTA-382556", "R-DDI-1369062", "R-DDI-2453902", "R-DDI-382556", "R-DDI-5683826", "R-DDI-6798695", "R-DDI-8963896", "R-HSA-1369062", "R-HSA-1989781", "R-HSA-2453902", "R-HSA-382556", "R-HSA-5682113", "R-HSA-5682294", "R-HSA-5683678", "R-HSA-5683826", "R-H...

[ "EC:7.6.2", "REACTOME:R-BTA-2453902", "REACTOME:R-BTA-382556", "REACTOME:R-DDI-1369062", "REACTOME:R-DDI-2453902", "REACTOME:R-DDI-382556", "REACTOME:R-DDI-5683826", "REACTOME:R-DDI-6798695", "REACTOME:R-DDI-8963896", "REACTOME:R-HSA-1369062", "REACTOME:R-HSA-1989781", "REACTOME:R-HSA-2453902"...

32

[ "5xjy", "7e7i", "7e7o", "7e7q", "7lkp", "7lkz", "7m1p", "7m1q", "7roq", "7tbw", "7tby", "7tbz", "7tc0", "7tdt", "7w01", "7w02", "8edw", "8ee6", "8eeb", "8eop", "8f5b", "8y1o", "8y1p" ]

23

[ "PUB00072378", "PUB00155818", "PUB00155819", "PUB00155820", "PUB00155821", "PUB00156027", "PUB00156028", "PUB00156029", "PUB00156030" ]

[ "24201375", "28602350", "36889459", "34158497", "33605212", "28887056", "29847635", "31473345", "33375396" ]

[ "The ATP-binding cassette transporter-2 (ABCA2) regulates esterification of plasma membrane cholesterol by modulation of sphingolipid metabolism.", "Structure of the Human Lipid Exporter ABCA1.", "Activity and Structural Dynamics of Human ABCA1 in a Lipid Membrane.", "Structural basis of substrate recognition...

[ 2014, 2017, 2023, 2021, 2021, 2017, 2018, 2019, 2020 ]

9

[]

0

null

[ "Eukaryota", "Shewanella electrica", "freshwater metagenome" ]

[ 16546, 1, 1 ]

3

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 6, 1, 17, 9, 37, 38, 43 ]

7

true

Domain

ABCA1-4-like, C-terminal R2 regulatory domain

R2_ABCA1-4-like

6

IPR056266

56,266

CDCP1, third and sixth CUB domain

CDCP1_CUB_3rd_6th

Domain

1,228

false

This domain is found in the human CUB domain-containing protein 1 (CDCP1) and related proteins. This entry represents the third and the sixth of the tandem of CUB domains. CDCP1 may be involved in cell adhesion and cell matrix association. It also plays a role in the regulation of anchorage versus migration or prolifer...

[]

0

[ "PFAM" ]

[ "PF23665" ]

[ "CDCP1_CUB_6" ]

[ 1228 ]

1

[]

0

[]

0

[ "PUB00155580", "PUB00155581" ]

[ "11466621", "15153610" ]

[ "Identification of a novel gene, CDCP1, overexpressed in human colorectal cancer.", "CDCP1 identifies a broad spectrum of normal and malignant stem/progenitor cell subsets of hematopoietic and nonhematopoietic origin." ]

[ 2001, 2004 ]

2

[]

0

null

[ "Vertebrata" ]

[ 1228 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 3, 3, 3, 2 ]

4

true

Domain

CDCP1, third and sixth CUB domain

CDCP1_CUB_3rd_6th

6

IPR056267

56,267

Ada2b, tri-helical domain

Ada2b_C

Domain

1,084

false

This domain is found at the C-terminal of Transcriptional adapter 2B from Drosophila melanogaster (Ada2b) and similar animal proteins. Ada2b is required for the function of some acidic activation domains, which activate transcription from a distant site [ , ]. This domain is predicted to show a tri-helical structure.

[]

0

[ "PFAM" ]

[ "PF24533" ]

[ "Tri-helical_Ada2b_C" ]

[ 1084 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-DME-5689880", "R-DRE-5689880", "R-HSA-3214847", "R-HSA-5689880" ]

[ "REACTOME:R-DME-5689880", "REACTOME:R-DRE-5689880", "REACTOME:R-HSA-3214847", "REACTOME:R-HSA-5689880" ]

4

[]

0

[ "PUB00073508", "PUB00155887" ]

[ "12697829", "12482983" ]

[ "Two Drosophila Ada2 homologues function in different multiprotein complexes.", "Two different Drosophila ADA2 homologues are present in distinct GCN5 histone acetyltransferase-containing complexes." ]

[ 2003, 2003 ]

2

[]

0

null

[ "Eukaryota" ]

[ 1084 ]

1

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 1, 2, 2, 2 ]

5

true

Domain

Ada2b, tri-helical domain

Ada2b_C

9

IPR056268

56,268

CDCP1, first CUB domain

CUB_CDCP1_1st

Domain

1,095

false

This domain is found at the N-terminal of human CUB domain-containing protein 1 (CDCP1) and related proteins. This entry represents the first of the tandem of CUB domains. CDCP1 may be involved in cell adhesion and cell matrix association. It also plays a role in the regulation of anchorage versus migration or prolifer...

[]

0

[ "PFAM" ]

[ "PF23667" ]

[ "CUB_CDCP1_1" ]

[ 1095 ]

1

[]

0

[]

0

[ "PUB00155580", "PUB00155581" ]

[ "11466621", "15153610" ]

[ "Identification of a novel gene, CDCP1, overexpressed in human colorectal cancer.", "CDCP1 identifies a broad spectrum of normal and malignant stem/progenitor cell subsets of hematopoietic and nonhematopoietic origin." ]

[ 2001, 2004 ]

2

[]

0

null

[ "Gnathostomata" ]

[ 1095 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 3, 3, 3, 2 ]

4

true

Domain

CDCP1, first CUB domain

CUB_CDCP1_1st

9

IPR056269

56,269

CDCP1, second and fifth CUB domain

CUB_CDCP1_2nd_5th

Domain

1,215

false

This domain is found in the human CUB domain-containing protein 1 (CDCP1) and related proteins. This entry represents the second and fifth of the tandem of CUB domains. CDCP1 may be involved in cell adhesion and cell matrix association. It also plays a role in the regulation of anchorage versus migration or proliferati...

[]

0

[ "PFAM" ]

[ "PF23668" ]

[ "CUB_CDCP1_2" ]

[ 1215 ]

1

[]

0

[]

0

[ "PUB00155580", "PUB00155581" ]

[ "11466621", "15153610" ]

[ "Identification of a novel gene, CDCP1, overexpressed in human colorectal cancer.", "CDCP1 identifies a broad spectrum of normal and malignant stem/progenitor cell subsets of hematopoietic and nonhematopoietic origin." ]

[ 2001, 2004 ]

2

[]

0

null

[ "Gnathostomata" ]

[ 1215 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 3, 3, 3, 2 ]

4

true

Domain

CDCP1, second and fifth CUB domain

CUB_CDCP1_2nd_5th

6

IPR056270

56,270

A disintegrin and metalloproteinase with thrombospondin motifs 17/19, C-terminal helical domain

ADAMTS17/19_C

Domain

1,541

false

This domain is found C-terminal in some members of ADAMTS family (ADAMTS - A Disintegrin And Metalloproteinase domain, with ThromboSpondin type-1 modules) such as human ADAMTS17 and ADAMTS19. Members of the ADAMTS family of zinc-dependent proteases play important roles in a variety of normal and pathological conditions...

[]

0

[ "PFAM" ]

[ "PF23178" ]

[ "ADAMTS_C" ]

[ 1541 ]

1

[ "EC", "METACYC", "REACTOME", "REACTOME", "REACTOME" ]

[ "3.4.24.-", "PWY-8119", "R-HSA-5083635", "R-HSA-5173214", "R-MMU-5173214" ]

[ "EC:3.4.24.-", "METACYC:PWY-8119", "REACTOME:R-HSA-5083635", "REACTOME:R-HSA-5173214", "REACTOME:R-MMU-5173214" ]

5

[]

0

[]

0

[ "IPR010909" ]

[]

1

0

1

[ "Vertebrata" ]

[ 1541 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 4, 4, 5, 4 ]

4

true

Domain

A disintegrin and metalloproteinase with thrombospondin motifs 17/19, C-terminal helical domain

ADAMTS17/19_C

7

IPR056272

56,272

ADAMTS-like protein 1 domain

ADAMTSL1_dom

Domain

566

false

This domain is found in human ADAMTS-like protein 1 (ADAMTSL1) and in similar proteins mainly found in vertebrates. This domain is predicted to adopt a mainly α-helical structure.

[]

0

[ "PFAM" ]

[ "PF24484" ]

[ "ADAMTSL1" ]

[ 566 ]

1

[ "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-5083635", "R-HSA-5173214", "R-MMU-5173214" ]

[ "REACTOME:R-HSA-5083635", "REACTOME:R-HSA-5173214", "REACTOME:R-MMU-5173214" ]

3

[]

0

[]

0

[]

0

null

[ "Vertebrata" ]

[ 566 ]

1

[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 2, 5 ]

3

true

Domain

ADAMTS-like protein 1 domain

ADAMTSL1_dom

2

IPR056273

56,273

CDK5 regulatory subunit-associated protein 2/Myomegalin, coiled coil

CDK5RAP2_MYOME_CC

Domain

3,645

false

This domain is found in human CDK5 regulatory subunit-associated protein 2 (CDK5RAP2), myomegalin (MYOME, also known as PDE4DIP) and related sequences mainly from vertebrates. CDK5RAP2 is a potential regulator of CDK5 activity that plays a role in the spindle checkpoint activation and regulates centrosomal maturation [...

[]

0

[ "PFAM" ]

[ "PF23246" ]

[ "CC_CDK5RAP2" ]

[ 3645 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-2565942", "R-HSA-380259", "R-HSA-380270", "R-HSA-380284", "R-HSA-380320", "R-HSA-5620912", "R-HSA-8854518", "R-MMU-2565942", "R-MMU-380259", "R-MMU-380270", "R-MMU-380284", "R-MMU-380320", "R-MMU-5620912", "R-MMU-8854518", "R-RNO-2565942", "R-RNO-380259", "R-RNO-380270", "R-...

[ "REACTOME:R-HSA-2565942", "REACTOME:R-HSA-380259", "REACTOME:R-HSA-380270", "REACTOME:R-HSA-380284", "REACTOME:R-HSA-380320", "REACTOME:R-HSA-5620912", "REACTOME:R-HSA-8854518", "REACTOME:R-MMU-2565942", "REACTOME:R-MMU-380259", "REACTOME:R-MMU-380270", "REACTOME:R-MMU-380284", "REACTOME:R-MMU...

21

[ "6x0v", "9g3y", "9g3z", "9g40", "9h9p", "9qvm" ]

6

[ "PUB00091368", "PUB00093343", "PUB00099093", "PUB00156007", "PUB00156008", "PUB00156009" ]

[ "29162697", "26485573", "32610146", "25217626", "27666745", "28814570" ]

[ "EB1-binding-myomegalin protein complex promotes centrosomal microtubules functions.", "Cep169, a Novel Microtubule Plus-End-Tracking Centrosomal Protein, Binds to CDK5RAP2 and Regulates Microtubule Stability.", "MZT Proteins Form Multi-Faceted Structural Modules in the γ-Tubulin Ring Complex.", "A newly iden...

[ 2017, 2015, 2020, 2014, 2016, 2017 ]

6

[]

0

null

[ "Eumetazoa" ]

[ 3645 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 94, 32, 7, 25 ]

4

true

Domain

CDK5 regulatory subunit-associated protein 2/Myomegalin, coiled coil

CDK5RAP2_MYOME_CC

6

IPR056274

56,274

Adhesion G-protein coupled receptor F3, Ig-like domain

Ig_ADGRF3

Domain

367

false

This immunoglobulin-like (Ig-like) domain is found in human Adhesion G-protein coupled receptor F3 (ADGRF3) and similar proteins from vertebrates. ADGRF3 is an orphan receptor. In homo sapiens, ADGRF3 is a receptor for soluble FNDC4 (sFNDC4), required for proper systemic glucose tolerance, specifically sensitising whit...

[]

0

[ "PFAM" ]

[ "PF24528" ]

[ "Ig_ADGRF3" ]

[ 367 ]

1

[]

0

[]

0

[ "PUB00160216", "PUB00160436" ]

[ "36716818", "34016966" ]

[ "Crystal Structure of the Extracellular Domains of GPR110.", "Orphan GPR116 mediates the insulin sensitizing effects of the hepatokine FNDC4 in adipose tissue." ]

[ 2023, 2021 ]

2

[]

0

null

[ "Vertebrata" ]

[ 367 ]

1

[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 1, 5 ]

3

true

Domain

Adhesion G-protein coupled receptor F3, Ig-like domain

Ig_ADGRF3

7

IPR056275

56,275

Cdr2, UBA domain

UBA_Crd2

Domain

5

false

The protein kinase Cdr2 from S.pombe promotes mitotic entry by organising cortical oligomeric nodes that lead to inhibition of Wee1 which itself inhibits the cyclin-dependent kinase Cdk1 [ ]. Cdr2 may act as a dosage-dependent regulator of cell size by sequestering its substrate Wee1 in cytoplasmic clusters, away from ...

[]

0

[ "PFAM" ]

[ "PF23149" ]

[ "UBA_Crd2" ]

[ 5 ]

1

[]

0

[]

0

[ "PUB00155898" ]

[ "36574843" ]

[ "Regulation of cell size and Wee1 kinase by elevated levels of the cell cycle regulatory protein kinase Cdr2." ]

[ 2023 ]

1

[]

0

null

[ "Schizosaccharomyces" ]

[ 5 ]

1

[ "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1 ]

1

true

Domain

Cdr2, UBA domain

UBA_Crd2

4

IPR056276

56,276

AtC3H46-like, PABC-like domain

AtC3H46-like_PABC-like

Domain

3,848

false

This PABC-like domain is found N-terminal in Zinc finger CCCH domain-containing protein 46 (AtC3H46) from Arabidopsis thaliana and related proteins specific to plants. AtC3H46 is know to possess RNA-binding and ribonuclease activities in vitro [ ].

[]

0

[ "PFAM" ]

[ "PF23182" ]

[ "PABC_AtC3H46" ]

[ 3848 ]

1

[]

0

[]

0

[ "PUB00083345" ]

[ "18582464" ]

[ "Ribonuclease activity is a common property of Arabidopsis CCCH-containing zinc-finger proteins." ]

[ 2008 ]

1

[]

0

null

[ "Streptophyta" ]

[ 3848 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 45, 14, 51 ]

3

true

Domain

AtC3H46-like, PABC-like domain

AtC3H46-like_PABC-like

3

IPR056277

56,277

AIP/AIPL, N-terminal FKBP-type PPIase domain

PPIase_AIP

Domain

3,091

false

This is the FKBP-type peptidyl-prolyl cis/trans isomerase (PPIase) domain of human AH receptor-interacting protein (AIP), AIPL1 and similar animal proteins. AIP may play a positive role in AHR-mediated (aromatic hydrocarbon receptor) signalling. This domain shows a typical FKBP fold with five antiparallel β-strands for...

[]

0

[ "PFAM" ]

[ "PF23322" ]

[ "PPIase_AIP" ]

[ 3091 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-8937144", "R-HSA-8950505", "R-MMU-8937144", "R-RNO-8937144" ]

[ "REACTOME:R-HSA-8937144", "REACTOME:R-HSA-8950505", "REACTOME:R-MMU-8937144", "REACTOME:R-RNO-8937144" ]

4

[ "2lkn", "5u9a", "5u9i", "5u9j", "5u9k", "5v35", "7zub", "8eoa", "8h77", "8qmo" ]

10

[ "PUB00155811", "PUB00155812" ]

[ "23418784", "28739921" ]

[ "The FKBP-type domain of the human aryl hydrocarbon receptor-interacting protein reveals an unusual Hsp90 interaction.", "Unique structural features of the AIPL1-FKBP domain that support prenyl lipid binding and underlie protein malfunction in blindness." ]

[ 2013, 2017 ]

2

[]

0

null

[ "Eukaryota" ]

[ 3091 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 4, 4, 38, 5, 8 ]

6

true

Domain

AIP/AIPL, N-terminal FKBP-type PPIase domain

PPIase_AIP

5

IPR056278

56,278

CdrL-like, middle region

CdrL_M

Domain

219

false

This entry represents a region found in the middle of CdrL (cell division regulator long, HVO_0583, ) from Haloferax volcanii and similar sequences from halobacteria [ , , ]. CdrL has at the N-terminal and at the C-terminal. According to structure predictions, this region may consist of an α-helix followed by a disorde...

[]

0

[ "PFAM" ]

[ "PF24252" ]

[ "CdrL_M" ]

[ 219 ]

1

[]

0

[]

0

[ "PUB00155582", "PUB00155583", "PUB00155584" ]

[ "32788376", "33903747", "34253062" ]

[ "The Ribbon-Helix-Helix Domain Protein CdrS Regulates the Tubulin Homolog ftsZ2 To Control Cell Division in Archaea.", "Cell division in the archaeon Haloferax volcanii relies on two FtsZ proteins with distinct functions in division ring assembly and constriction.", "CdrS Is a Global Transcriptional Regu...

[ 2020, 2021, 2021 ]

3

[]

0

null

[ "Halobacteriales" ]

[ 219 ]

1

[]

0

true

Domain

CdrL-like, middle region

CdrL_M

3

IPR056279

56,279

Aip3p/Bud6, N-terminal domain

Aip3p_Bud6_N

Domain

1,957

false

This domain is commonly located at the N-terminal end of Aip3p/Bud6 from fungi. This region is essential for its proper localisation on the plasma membrane [ ] and to bind to the microtubule (+) end binding protein Bim1 [ ]. Its absence results in altered localisation patterns, although the secretory pathway remains fu...

[]

0

[ "PFAM" ]

[ "PF23153" ]

[ "Aip3p_Bud6_N" ]

[ 1957 ]

1

[]

0

[]

0

[ "PUB00007877", "PUB00155488", "PUB00155489" ]

[ "10679021", "31362951", "34818061" ]

[ "The secretory pathway mediates localization of the cell polarity regulator Aip3p/Bud6p.", "YFR016c/Aip5 is part of an actin nucleation complex in yeast.", "A teamwork promotion of formin-mediated actin nucleation by Bud6 and Aip5 in Saccharomyces cerevisiae." ]

[ 2000, 2019, 2022 ]

3

[]

0

null

[ "Candidatus Southlakia epibionticum", "Eukaryota" ]

[ 1, 1956 ]

2

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 1, 1 ]

3

true

Domain

Aip3p/Bud6, N-terminal domain

Aip3p_Bud6_N

6

IPR056280

56,280

AIPP2-like, SPOC-like domain

AIPP2-like_SPOC

Domain

4,233

false

This entry represents the SPOC-like domain found at the C-terminal of PHD-containing proteins present in plants, including ASI1-immunoprecipitated protein 2 (AIPP2 or PHD3) and PHD finger-containing protein 1/6 from Arabidopsis thaliana. Together with AIPP3/BDT1, these proteins cooperate to form a BAH-PHD bivalent hist...

[]

0

[ "PFAM" ]

[ "PF23121" ]

[ "SPOC_AIPP2" ]

[ 4233 ]

1

[]

0

[]

0

[ "PUB00013949", "PUB00153327", "PUB00153328" ]

[ "12897056", "33277495", "33433058" ]

[ "A conserved structural motif reveals the essential transcriptional repression function of Spen proteins and their role in developmental signaling.", "Coupling of H3K27me3 recognition with transcriptional repression through the BAH-PHD-CPL2 complex in Arabidopsis.", "A histone H3K27me3 reader cooperates with a ...

[ 2003, 2020, 2021 ]

3

[]

0

null

[ "Streptophytina" ]

[ 4233 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 30, 32, 62 ]

3

true

Domain

AIPP2-like, SPOC-like domain

AIPP2-like_SPOC

1

IPR056281

56,281

ATG1a/b/c, MIT domain

MIT_ATG1a/b/c

Domain

1,661

false

This is the MIT domain found at the C-terminal of ATG1a/b/c proteins from Arabidopsis thaliana and related plant sequences. These proteins are serine/threonine protein kinases involved in autophagy. They form the ATG1-ATG13 protein kinase complex which initiates autophagosome formation and regulates downstream events r...

[]

0

[ "PFAM" ]

[ "PF24497" ]

[ "MIT_ATG1" ]

[ 1661 ]

1

[ "EC" ]

[ "2.7.11.-" ]

[ "EC:2.7.11.-" ]

1

[]

0

[ "PUB00155745", "PUB00155746" ]

[ "36053201", "35961047" ]

[ "14-3-3 proteins contribute to autophagy by modulating SINAT-mediated degradation of ATG13.", "Type one protein phosphatase regulates fixed-carbon starvation-induced autophagy in Arabidopsis." ]

[ 2022, 2022 ]

2

[]

0

null

[ "Viridiplantae" ]

[ 1661 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 18, 11, 36 ]

3

true

Domain

ATG1a/b/c, MIT domain

MIT_ATG1a/b/c

1

IPR056282

56,282

MROH2B-like, N-terminal HEAT-repeats domain

MROH2B-like_N_HEAT

Domain

4,026

false

This entry represents a region of HEAT repeats found at the N-terminal end of maestro heat-like repeat-containing proteins, including Maestro heat-like repeat -containing protein family member 2B from mouse (MROH2B, also known as SPIF), which may play a role in the process of sperm capacitation [ ].

[]

0

[ "PFAM" ]

[ "PF23221" ]

[ "HEAT_MROH2B_1st" ]

[ 4026 ]

1

[]

0

[]

0

[ "PUB00098264" ]

[ "27105888" ]

[ "A novel germ cell protein, SPIF (sperm PKA interacting factor), is essential for the formation of a PKA/TCP11 complex that undergoes conformational and phosphorylation changes upon capacitation." ]

[ 2016 ]

1

[]

0

null

[ "Eukaryota" ]

[ 4026 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 7, 1, 10, 2, 8, 11, 2, 21, 2 ]

9

true

Domain

MROH2B-like, N-terminal HEAT-repeats domain

MROH2B-like_N_HEAT

6

IPR056283

56,283

CdsD, C-terminal

CdsD_C

Domain

77

false

This domain is found at the C-terminal of CdsD from Chlamydia trachomatis ( ) and similar sequences. CdsD is a structural contact-dependent secretion (Cds) protein that form part of the basal body of the type III secretion system (T3SS) injectisome of the bacteria. The periplasmic part of this protein contains at least...

[]

0

[ "PFAM" ]

[ "PF23862" ]

[ "CdsD_C" ]

[ 77 ]

1

[]

0

[]

0

[ "PUB00153859" ]

[ "26914207" ]

[ "The extended structure of the periplasmic region of CdsD, a structural protein of the type III secretion system of Chlamydia trachomatis." ]

[ 2016 ]

1

[]

0

null

[ "Bacteria", "ecological metagenomes" ]

[ 71, 6 ]

2

[]

0

true

Domain

CdsD, C-terminal

CdsD_C

7

IPR056284

56,284

AIR9-like, A9 domain

AIR9-like_A9

Domain

3,371

false

This entry represents an Ig-like domain known as the A9 domain that is repeated 10/11 times in AIR9 (187-kDa microtubule-associated protein AIR9) from Arabidopsis thaliana [ ]. This domain is also found only once, often associated with in a group of plant and bacterial uncharacterised proteins. AIR9 and TAN1 function r...

[]

0

[ "PFAM" ]

[ "PF23197" ]

[ "IG_AIR9" ]

[ 3371 ]

1

[]

0

[]

0

[ "PUB00155668", "PUB00155669" ]

[ "17027491", "36005863" ]

[ "Microtubule-associated AIR9 recognizes the cortical division site at preprophase and cell-plate insertion.", "The localization of PHRAGMOPLAST ORIENTING KINESIN1 at the division site depends on the microtubule-binding proteins TANGLED1 and AUXIN-INDUCED IN ROOT CULTURES9 in Arabidopsis." ]

[ 2006, 2022 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "ecological metagenomes" ]

[ 217, 3150, 4 ]

3

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 26, 17, 65 ]

3

true

Domain

AIR9-like, A9 domain

AIR9-like_A9

6

IPR056285

56,285

CdsD, PD1 domain

CdsD_PD1

Domain

47

false

This domain is found in CdsD from Chlamydia trachomatis ( ) and similar sequences. CdsD is a structural contact-dependent secretion (Cds) protein that forms part of the basal body of the type III secretion system (T3SS) injectisome of the bacteria. The periplasmic part of this protein contains 3 domains: PD1 (represent...

[]

0

[ "PFAM" ]

[ "PF23863" ]

[ "CdsD_PD1" ]

[ 47 ]

1

[]

0

[ "4qo6", "4qq0" ]

2

[ "PUB00153859" ]

[ "26914207" ]

[ "The extended structure of the periplasmic region of CdsD, a structural protein of the type III secretion system of Chlamydia trachomatis." ]

[ 2016 ]

1

[]

0

null

[ "Bacteria", "marine sediment metagenome" ]

[ 46, 1 ]

2

[]

0

true

Domain

CdsD, PD1 domain

CdsD_PD1

7

IPR056286

56,286

CELSR1-3-like, ninth cadherin domain

Cadherin_CELSR1-3_9th

Domain

4,696

false

This entry represents the last of 9 tandem cadherin domains occurring in human Cadherin EGF LAG seven-pass G-type receptor 1-3 (CELSR1-3), its orthologue form Drosophila stan/Flamingo and similar proteins predominantly found in animals. CELSR2 is a receptor that may have an important role in cell/cell signalling during...

[]

0

[ "PFAM" ]

[ "PF23592" ]

[ "Cadherin_CELSR2_9th" ]

[ 4696 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-DME-350368", "R-DME-350376", "R-DME-350379", "R-DME-350411", "R-DME-350480", "R-DME-450728" ]

[ "REACTOME:R-DME-350368", "REACTOME:R-DME-350376", "REACTOME:R-DME-350379", "REACTOME:R-DME-350411", "REACTOME:R-DME-350480", "REACTOME:R-DME-450728" ]

6

[ "8vy2" ]

1

[ "PUB00155565", "PUB00155566", "PUB00155567", "PUB00155568", "PUB00155569", "PUB00156010", "PUB00156011", "PUB00156012", "PUB00156013", "PUB00156014" ]

[ "27161523", "27298358", "30033219", "27782885", "32963095", "10490098", "23292348", "22442082", "23376536", "28052552" ]

[ "Structural Basis of Diverse Homophilic Recognition by Clustered α- and β-Protocadherins.", "Structural basis of adhesive binding by desmocollins and desmogleins.", "Zooming in on Cadherin-23: Structural Diversity and Potential Mechanisms of Inherited Deafness.", "γ-Protocadherin structural diversity and func...

[ 2016, 2016, 2018, 2016, 2020, 1999, 2013, 2012, 2013, 2017 ]

10

[]

0

null

[ "Eumetazoa" ]

[ 4696 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 20, 6, 9, 5, 13 ]

6

true

Domain

CELSR1-3-like, ninth cadherin domain

Cadherin_CELSR1-3_9th

3