LiteFold/InterPro · Datasets at Hugging Face

IPR058173

58,173

FcpB

Family

129

false

This entry represents the uncharacterised bacterial proteins flagellar-coiling FcpB mainly from Leptospira species, including flagellar-coiling FcpB from Leptospira interrogans (LIC_11848, ) [ , ].

[]

0

[ "NCBIFAM", "PFAM" ]

[ "NF047844", "PF28294" ]

[ "FlgcoilFcpBLepto", "FcpB" ]

[ 120, 129 ]

2

[]

0

[ "6nqz", "6pwb" ]

2

[ "PUB00159395", "PUB00161090" ]

[ "29868490", "22174381" ]

[ "FcpB Is a Surface Filament Protein of the Endoflagellum Required for the Motility of the Spirochete Leptospira.", "Methylation and in vivo expression of the surface-exposed Leptospira interrogans outer-membrane protein OmpL32." ]

[ 2018, 2012 ]

2

[]

0

null

[ "Leptospiraceae" ]

[ 129 ]

1

[]

0

true

Family

FcpB

4

IPR058174

58,174

LIC13410-like

Family

124

false

This entry represents uncharacterised lipoproteins from Leptospira, including LIC13410 from Leptospira interrogans ( ). They contain a small β-sheet surrounded by α-helices.

[]

0

[ "NCBIFAM", "PFAM" ]

[ "NF047813", "PF28300" ]

[ "LIC13410_lipo", "LIC13410" ]

[ 118, 124 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Leptospira", "hydrocarbon metagenome" ]

[ 123, 1 ]

2

[]

0

true

Family

LIC13410-like

5

IPR058175

58,175

ElxI1-like

Family

46

false

This entry represents epilancin biosynthesis-related proteins (Elxl1, ) from Staphylococcus species [ ].

[]

0

[ "NCBIFAM", "PFAM" ]

[ "NF047829", "PF28301" ]

[ "epilancin_ElxI1", "ElxI1" ]

[ 38, 46 ]

2

[]

0

[]

0

[ "PUB00159170" ]

[ "21802007" ]

[ "Biosynthesis of the antimicrobial peptide epilancin 15X and its N-terminal lactate." ]

[ 2011 ]

1

[]

0

null

[ "Staphylococcaceae" ]

[ 46 ]

1

[]

0

true

Family

ElxI1-like

7

IPR058176

58,176

LIC11874-like

Family

129

false

This entry represents uncharacterised lipoproteins from Leptospirales, including LIC11874 from Leptospira interrogans ( ). Some members are associated with a prokaryotic membrane lipoprotein lipid attachment site ( ).

[]

0

[ "NCBIFAM", "PFAM" ]

[ "NF047799", "PF28303" ]

[ "LIC11874_lipo", "LIC11874" ]

[ 112, 129 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Leptospiraceae" ]

[ 129 ]

1

[]

0

true

Family

LIC11874-like

1

IPR058177

58,177

LIC11435-like

Family

124

false

Members of this family of putative surface-exposed proteins include LIC11435 from Leptospira interrogans ( ) and similar proteins from Leptospira. Some members contain the domain DUF5683 ( ). The signal peptide region is not well conserved in this protein family [ ].

[]

0

[ "NCBIFAM" ]

[ "NF047756" ]

[ "LIC11435_fam" ]

[ 124 ]

1

[]

0

[]

0

[ "PUB00159320" ]

[ "28352257" ]

[ "A Novel Pan-Genome Reverse Vaccinology Approach Employing a Negative-Selection Strategy for Screening Surface-Exposed Antigens against leptospirosis." ]

[ 2017 ]

1

[]

0

null

[ "Leptospira" ]

[ 124 ]

1

[]

0

true

Family

LIC11435-like

8

IPR058178

58,178

LBF_1134-like

Family

32

false

This family includes LBF_1134 from Leptospira biflexa ( ), a saprophytic (non-pathogenic) species of Leptospira. Members of this family are uncharacterised lipoproteins.

[]

0

[ "NCBIFAM", "PFAM" ]

[ "NF047759", "PF28304" ]

[ "LBF_1134_fam", "LBF_1134" ]

[ 32, 32 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Leptospira" ]

[ 32 ]

1

[]

0

true

Family

LBF_1134-like

6

IPR058179

58,179

LBF_4227-like

Family

126

false

This entry includes uncharacterised proteins from Leptospira. Some members are annotated as Phage holin family proteins.

[]

0

[ "NCBIFAM", "PFAM" ]

[ "NF047761", "PF28305" ]

[ "LBF_4227_fam", "LBF_4227" ]

[ 125, 126 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Leptospira" ]

[ 126 ]

1

[]

0

true

Family

LBF_4227-like

5

IPR058180

58,180

BPSS1187-like

Family

294

false

BPSS1187 from Burkholderia pseudomallei ( ) was identified as a type III secretion system (T3SS) protein and a useful marker for detecting Burkholderia pseudomallei and discriminating it from multiple other Burkholderia species. Members of this family occur in genera widely separated taxonomically, including Leptospira...

[]

0

[ "NCBIFAM" ]

[ "NF047580" ]

[ "BPSS1187_fam" ]

[ 294 ]

1

[]

0

[]

0

[ "PUB00159593" ]

[ "21803915" ]

[ "Highly sensitive direct detection and quantification of Burkholderia pseudomallei bacteria in environmental soil samples by using real-time PCR." ]

[ 2011 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "ecological metagenomes" ]

[ 289, 3, 2 ]

3

[]

0

true

Family

BPSS1187-like

6

IPR058181

58,181

LIC10012-like

Family

131

false

This entry epresents a group of uncharacterised proteins from Leptospira, including LIC10012 ( ) from Leptospira interrogans. Members of this family of putative surface-exposed proteins are found broadly throughout the genus Leptospira, and appear to have a VWA (von Willibrand factor type A) domain [ ].

[]

0

[ "NCBIFAM", "PFAM" ]

[ "NF047585", "PF28306" ]

[ "LIC10012_fam", "LIC10012" ]

[ 126, 131 ]

2

[]

0

[]

0

[ "PUB00159320" ]

[ "28352257" ]

[ "A Novel Pan-Genome Reverse Vaccinology Approach Employing a Negative-Selection Strategy for Screening Surface-Exposed Antigens against leptospirosis." ]

[ 2017 ]

1

[]

0

null

[ "Leptospira" ]

[ 131 ]

1

[]

0

true

Family

LIC10012-like

4

IPR058182

58,182

LA_1883-like

Family

128

false

This entry represents a group of uncharacterised proteins from Leptospira, including LA_1883 ( ) from Leptospira interrogans. An apparent signal peptide and an invariant Cys residue at about position 21 suggests that members of this family may be lipoproteins.

[]

0

[ "NCBIFAM", "PFAM" ]

[ "NF047592", "PF28307" ]

[ "LA_1883_fam", "LA_1883" ]

[ 121, 128 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Leptospiraceae", "ecological metagenomes" ]

[ 126, 2 ]

2

[]

0

true

Family

LA_1883-like

1

IPR058183

58,183

LBF_2017-like, N-terminal domain

LBF_2017-like_N

Domain

63

false

This entry describes an N-terminal domain specific to a group of uncharacterised proteins from Leptospira, including from Leptospira biflexa, LBF_2017. The domain is followed by in many members.

[]

0

[ "NCBIFAM", "PFAM" ]

[ "NF047607", "PF28308" ]

[ "LBF_2017_Nterm", "LBF_2017-like_N" ]

[ 63, 63 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Leptospira" ]

[ 63 ]

1

[]

0

true

Domain

LBF_2017-like, N-terminal domain

LBF_2017-like_N

7

IPR058184

58,184

AgmC-like, N-terminal domain

AgmC-like_N

Domain

113

false

This entry includes surface proteins from Myxococcales with a wide variety of architectures but a shared N-terminal domain of 400 amino acids. The founding member, (AAO22852.1) from Myxococcus xanthus, was named AgmC because its loss of function affects adventurous gliding motility [ ]. Some proteins included in this e...

[]

0

[ "NCBIFAM" ]

[ "NF047640" ]

[ "gliding_AgmC_N" ]

[ 113 ]

1

[]

0

[]

0

[ "PUB00015301" ]

[ "12828649" ]

[ "Identification of genes required for adventurous gliding motility in Myxococcus xanthus with the transposable element mariner." ]

[ 2003 ]

1

[]

0

null

[ "Cystobacterineae" ]

[ 113 ]

1

[]

0

true

Domain

AgmC-like, N-terminal domain

AgmC-like_N

4

IPR058185

58,185

LIC11073-like

Family

127

false

This entry includes LIC11073 from Leptospira interrogans and similar sequences from Leptospira species. Members of this family are probable lipoproteins with an average length of about 250 amino acids. The C-terminal 100 residues contain 12 invariant Cys residues. The function is unknown.

[]

0

[ "NCBIFAM", "PFAM" ]

[ "NF047587", "PF28309" ]

[ "lipo_LIC11073", "LIC11073" ]

[ 124, 127 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Leptospiraceae" ]

[ 127 ]

1

[]

0

true

Family

LIC11073-like

5

IPR058186

58,186

MIGRI

Family

142

false

This uncharacterised protein family, named MIGRI, is widespread in Neisseriales. Members are small, averaging about 59 amino acids in length, and hydrophobic on both sides of a small central region rich in basic amino acids, suggesting these are membrane proteins.

[]

0

[ "NCBIFAM" ]

[ "NF047648" ]

[ "MIGRI_fam" ]

[ 142 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Betaproteobacteria" ]

[ 142 ]

1

[]

0

true

Family

MIGRI

5

IPR058187

58,187

Extended-spectrum beta-lactamase PER-1

PER-1

Family

49

false

This entry represents a group of beta-lactamases from gammaproteobacteria, including Extended-spectrum beta-lactamase PER-1 from Pseudomonas aeruginosa, which confers resistance to penicillins, as well as first-, second- and third-generation cephalosporins [ ] and has cefotaxime-hydrolysing activity [ , , ].

[ "GO:0008800" ]

[ "beta-lactamase activity" ]

[ "molecular_function" ]

1

[ "NCBIFAM" ]

[ "NF000389" ]

[ "blaPER" ]

[ 49 ]

1

[]

0

[ "4d2o", "6d3g" ]

2

[ "PUB00104013", "PUB00161020", "PUB00161021" ]

[ "8517722", "10325401", "9494118" ]

[ "Characterization of a novel extended-spectrum beta-lactamase from Pseudomonas aeruginosa.", "Site-directed mutagenesis of residues 164, 170, 171, 179, 220, 237 and 242 in PER-1 beta-lactamase hydrolysing expanded-spectrum cephalosporins.", "Role of residues 104, 164, 166, 238 and 240 in the substrate profile o...

[ 1993, 1999, 1998 ]

3

[ "IPR000871" ]

[]

1

0

1

[ "Pseudomonadota" ]

[ 49 ]

1

[]

0

true

Family

Extended-spectrum beta-lactamase PER-1

PER-1

4

IPR058188

58,188

YxiG-like

Domain

144

false

This entry represents a family of uncharacterised proteins found in actinobacteria. Although this family does not contain the YxiG protein from B. subtilis it is clearly related to it from a structural point of view. These proteins like YxiG are also strongly predicted to form homodimers.

[]

0

[ "PFAM" ]

[ "PF24712" ]

[ "YxiG_2" ]

[ 144 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria" ]

[ 144 ]

1

[]

0

true

Domain

YxiG-like

7

IPR058189

58,189

PH-like domain, ascomycota

PH-like_ascomyc

Domain

74

false

This entry represents a PH domain found in a small set of uncharacterised proteins from Ascomycota. These proteins generally have a DH-like domain found to the N-terminal side of this domain, with two further PH-like domains observed in the structure predictions.

[]

0

[ "PFAM" ]

[ "PF25409" ]

[ "PH_33" ]

[ 74 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Dikarya" ]

[ 74 ]

1

[]

0

true

Domain

PH-like domain, ascomycota

PH-like_ascomyc

4

IPR058190

58,190

Centrosomal protein of 85 kDa-like, CC4 coiled-coil domain

CC4_CEP85

Domain

1,975

false

This domain is found in human Centrosomal protein of 85 kDa (CEP85) and similar animal proteins. CEP85 functions as a regulator of centriole duplication through a direct interaction with STIL, a key factor involved in the early steps of centriole formation. This entry represents the coiled-coil domain within the C-term...

[]

0

[ "PFAM" ]

[ "PF24555" ]

[ "CC4_CEP85" ]

[ 1975 ]

1

[]

0

[ "5oi7", "5oid" ]

2

[ "PUB00091069" ]

[ "29712910" ]

[ "Direct binding of CEP85 to STIL ensures robust PLK4 activation and efficient centriole assembly." ]

[ 2018 ]

1

[]

0

null

[ "Eukaryota", "Pseudomonas" ]

[ 1970, 5 ]

2

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 9, 4, 5, 10 ]

4

true

Domain

Centrosomal protein of 85 kDa-like, CC4 coiled-coil domain

CC4_CEP85

5

IPR058191

58,191

Centrosome and spindle pole-associated protein 1, C-terminal

CSPP1_C

Domain

1,349

false

This domain is found at the C-terminal end of human Centrosome and spindle pole-associated protein 1 (CSPP1), which may play a role in cell-cycle-dependent microtubule organisation [ ]. This domain is predicted to show an α-helical configuration. This entry is specific to animal proteins.

[]

0

[ "PFAM" ]

[ "PF24578" ]

[ "CSPP1_C" ]

[ 1349 ]

1

[]

0

[]

0

[ "PUB00061695" ]

[ "16826565" ]

[ "CSPP and CSPP-L associate with centrosomes and microtubules and differently affect microtubule organization." ]

[ 2006 ]

1

[]

0

null

[ "Opisthokonta" ]

[ 1349 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 6, 26, 3, 5 ]

4

true

Domain

Centrosome and spindle pole-associated protein 1, C-terminal

CSPP1_C

3

IPR058192

58,192

Disease resistance protein Roq1-like, winged-helix domain

WHD_ROQ1-like

Domain

23,981

false

This entry represents the winged-helix domain (WHD) of Disease resistance protein Roq1 from Nicotiana benthamiana and related plant proteins. Roq1 specifically recognises the Xanthomonas and Pseudomonas effector proteins XopQ and HopQ1, and triggers cell death [ , ].

[]

0

[ "PFAM" ]

[ "PF23282" ]

[ "WHD_ROQ1" ]

[ 23981 ]

1

[ "EC", "METACYC" ]

[ "3.2.2.6", "PWY-5381" ]

[ "EC:3.2.2.6", "METACYC:PWY-5381" ]

2

[ "7crb", "7crc", "7dfv", "7jlu", "7jlv", "7jlx" ]

6

[ "PUB00098642", "PUB00098643", "PUB00161088" ]

[ "33273071", "33273074", "28891100" ]

[ "Direct pathogen-induced assembly of an NLR immune receptor complex to form a holoenzyme.", "Structure of the activated ROQ1 resistosome directly recognizing the pathogen effector XopQ.", "Roq1 mediates recognition of the Xanthomonas and Pseudomonas effector proteins XopQ and HopQ1." ]

[ 2020, 2020, 2017 ]

3

[]

0

null

[ "Bifidobacterium breve", "Viridiplantae", "marine sediment metagenome" ]

[ 2, 23978, 1 ]

3

[ "Arabidopsis thaliana" ]

[ 734 ]

1

true

Domain

Disease resistance protein Roq1-like, winged-helix domain

WHD_ROQ1-like

6

IPR058193

58,193

D-alanyl-D-alanine carboxypeptidase/YodJ, core domain

VanY/YodJ_core_dom

Domain

8,302

false

This entry represents the common core domain found in D-alanyl-D-alanine carboxypeptidases (DD-CPases) such as VanY and related proteins from the MEROPS peptidase M15B family mostly found in bacteria. This domain features a central twisted antiparallel β-sheet (β1-β6) flanked by two pairs of three α-helices (α2, α3, α6...

[]

0

[ "CDD" ]

[ "cd14852" ]

[ "LD-carboxypeptidase" ]

[ 8302 ]

1

[]

0

[ "4d0y", "4jid", "4mph", "4nt9", "4ox3", "4ox5", "4oxd", "5hnm", "5zhf", "5zhw", "6a6a" ]

11

[ "PUB00008189", "PUB00106228", "PUB00140359", "PUB00140738", "PUB00140739", "PUB00141666", "PUB00161022" ]

[ "8631706", "24909784", "9614968", "1510448", "24711382", "25664738", "9257766" ]

[ "Regulation of VanB-type vancomycin resistance gene expression by the VanS(B)-VanR (B) two-component regulatory system in Enterococcus faecalis V583.", "Structure of the LdcB LD-carboxypeptidase reveals the molecular basis of peptidoglycan recognition.", "Control of peptidoglycan synthesis in vancomycin-resista...

[ 1996, 2014, 1998, 1992, 2014, 2015, 1997 ]

7

[ "IPR003709" ]

[]

1

0

1

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 8216, 32, 54 ]

3

[ "Arabidopsis thaliana" ]

[ 1 ]

1

true

Domain

D-alanyl-D-alanine carboxypeptidase/YodJ, core domain

VanY/YodJ_core_dom

1

IPR058196

58,196

STOP1/2-like, C2H2-type zinc finger

Znf-C2H2_STOP1/2_C

Domain

2,082

false

This domain is found in Protein STOP 1 and 2 from Arabidopsis thaliana and similar sequences from plants. These proteins are probable transcription factors. This entry represents the C-terminal C2H2 or β-β-α zinc finger DNA-binding domain. STOP1 (sensitive to proton rhizotoxicity 1) regulates transcription of multiple ...

[]

0

[ "PFAM" ]

[ "PF23118" ]

[ "zf-C2H2_STOP2_C" ]

[ 2082 ]

1

[]

0

[]

0

[ "PUB00059248", "PUB00059249", "PUB00095772", "PUB00095773", "PUB00095774" ]

[ "18826429", "19321711", "23935008", "17535918", "19880795" ]

[ "Aluminum-activated citrate and malate transporters from the MATE and ALMT families function independently to confer Arabidopsis aluminum tolerance.", "STOP1 regulates multiple genes that protect arabidopsis from proton and aluminum toxicities.", "STOP2 activates transcription of several genes for Al- and low p...

[ 2009, 2009, 2014, 2007, 2009 ]

5

[]

0

null

[ "Eukaryota" ]

[ 2082 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 10, 17, 20 ]

3

true

Domain

STOP1/2-like, C2H2-type zinc finger

Znf-C2H2_STOP1/2_C

2

IPR058197

58,197

Imipenem-hydrolyzing beta-lactamase

NMC-A

Family

40

false

This entry represents a group of beta-lactamases from enterobacterales, including Imipenem-hydrolyzing beta-lactamase from Enterobacter cloacae (NMC-A) [ ].

[ "GO:0008800" ]

[ "beta-lactamase activity" ]

[ "molecular_function" ]

1

[ "NCBIFAM" ]

[ "NF000400" ]

[ "blaIMI" ]

[ 40 ]

1

[]

0

[ "1bue", "1bul" ]

2

[ "PUB00023744", "PUB00159746" ]

[ "9756914", "8878585" ]

[ "X-ray analysis of the NMC-A beta-lactamase at 1.64-A resolution, a class A carbapenemase with broad substrate specificity.", "Characterization of IMI-1 beta-lactamase, a class A carbapenem-hydrolyzing enzyme from Enterobacter cloacae." ]

[ 1998, 1996 ]

2

[ "IPR000871" ]

[]

1

0

1

[ "Enterobacteriaceae" ]

[ 40 ]

1

[]

0

true

Family

Imipenem-hydrolyzing beta-lactamase

NMC-A

3

IPR058198

58,198

Beta-lactamase SME-1

SME-1

Family

7

false

This entry represents a group of beta-lactamases from Serratia species, including Beta-lactamase SME-1 from Serratia marcescens. SME-1 confers resistance to the beta-lactam antibiotics, including penicillins, some cephalosporins and carbapenems acting via hydrolysis of the beta-lactam ring [ , ].

[ "GO:0008800" ]

[ "beta-lactamase activity" ]

[ "molecular_function" ]

1

[ "NCBIFAM" ]

[ "NF012142" ]

[ "blaSME" ]

[ 7 ]

1

[]

0

[]

0

[ "PUB00161027", "PUB00161028" ]

[ "11036019", "8092824" ]

[ "SME-type carbapenem-hydrolyzing class A beta-lactamases from geographically diverse Serratia marcescens strains.", "Cloning and sequence analysis of the gene for a carbapenem-hydrolyzing class A beta-lactamase, Sme-1, from Serratia marcescens S6." ]

[ 2000, 1994 ]

2

[ "IPR058220" ]

[]

1

0

1

[ "Serratia marcescens" ]

[ 7 ]

1

[]

0

true

Family

Beta-lactamase SME-1

SME-1

2

IPR058199

58,199

Metallo-beta-lactamase type 2/VIM/IMP-1

BlaB//VIM/IMP-1

Family

2,627

false

This protein family includes Metallo-beta-lactamase type 2 from Pseudomonas aeruginosa (BlaB), Metallo-beta-lactamase VIM-2 from Escherichia coli [ ], Metallo-beta-lactamase IMP-1 from Serratia marcescens and similar bacterial sequences. BlaB, also known as Bla-imp13, confers resistance to the different beta-lactam ant...

[ "GO:0008800" ]

[ "beta-lactamase activity" ]

[ "molecular_function" ]

1

[ "NCBIFAM" ]

[ "NF033088" ]

[ "bla_subclass_B1" ]

[ 2627 ]

1

[ "EC" ]

[ "3.5.2.6" ]

[ "EC:3.5.2.6" ]

1

[ "1a7t", "1a8t", "1bc2", "1bmc", "1bvt", "1dd6", "1ddk", "1dxk", "1hlk", "1jje", "1jjt", "1ko2", "1ko3", "1kr3", "1m2x", "1mqo", "1vgn", "1wuo", "1wup", "1znb", "2bc2", "2bfk", "2bfl", "2bfz", "2bg2", "2bg6", "2bg7", "2bg8", "2bga", "2bmi", "2doo", "2fhx"...

494

[ "PUB00160914", "PUB00161029", "PUB00161030", "PUB00161031" ]

[ "31744917", "20974864", "32205343", "33126240" ]

[ "A Single Salt Bridge in VIM-20 Increases Protein Stability and Antibiotic Resistance under Low-Zinc Conditions.", "Purification and biochemical characterization of IMP-13 metallo-beta-lactamase.", "Structure and Molecular Recognition Mechanism of IMP-13 Metallo-β-Lactamase.", "RNA-hydrolyzing activity of met...

[ 2019, 2011, 2020, 2020 ]

4

[ "IPR050855" ]

[ "IPR058044", "IPR058237" ]

1

2

0

[ "Bacteria", "unclassified sequences" ]

[ 2620, 7 ]

2

[]

0

true

Family

Metallo-beta-lactamase type 2/VIM/IMP-1

BlaB//VIM/IMP-1

6

IPR058200

58,200

Beta-lactamase TEM-12-like

TEM-12-like

Family

853

false

This entry represents a group of beta-lactamases mainly from gammaproteobacteria, including Beta-lactamase TEM-12 from Klebsiella oxytoca [ ]. TEM-type are the most prevalent beta-lactamases in enterobacteria.

[ "GO:0008800" ]

[ "beta-lactamase activity" ]

[ "molecular_function" ]

1

[ "NCBIFAM" ]

[ "NF000531" ]

[ "blaTEM" ]

[ 853 ]

1

[ "EC", "REACTOME" ]

[ "3.5.2.6", "R-HSA-9913143" ]

[ "EC:3.5.2.6", "REACTOME:R-HSA-9913143" ]

2

[ "1zg4", "1zg6", "3p98", "4zj1", "4zj2", "4zj3" ]

6

[ "PUB00161032" ]

[ "1329636" ]

[ "Transposition of the gene encoding a TEM-12 extended-spectrum beta-lactamase." ]

[ 1992 ]

1

[ "IPR000871" ]

[]

1

0

1

[ "Bacteria", "Eukaryota", "Methanosarcina mazei", "Viruses", "plasmids", "unclassified sequences" ]

[ 823, 12, 1, 3, 4, 10 ]

6

[ "Zea mays" ]

[ 1 ]

1

true

Family

Beta-lactamase TEM-12-like

TEM-12-like

1

IPR058201

58,201

Beta-lactamase ROB-1

ROB-1

Family

25

false

This entry represents a group of beta-lactamases from pasteurellales, including Beta-lactamase ROB-1from Haemophilus influenzae [ ].

[ "GO:0008800" ]

[ "beta-lactamase activity" ]

[ "molecular_function" ]

1

[ "NCBIFAM" ]

[ "NF033568" ]

[ "blaROB" ]

[ 25 ]

1

[ "EC" ]

[ "3.5.2.6" ]

[ "EC:3.5.2.6" ]

1

[]

0

[ "PUB00105177", "PUB00105178" ]

[ "2201253", "30561662" ]

[ "Sequence analysis and evolutionary perspectives of ROB-1 beta-lactamase.", "Plasmid-located extended-spectrum β-lactamase gene blaROB-2 in Mannheimia haemolytica." ]

[ 1990, 2019 ]

2

[ "IPR000871" ]

[]

1

0

1

[ "Pseudomonadati" ]

[ 25 ]

1

[]

0

true

Family

Beta-lactamase ROB-1

ROB-1

1

IPR058202

58,202

Beta-lactamase BlaA, yersinia

BlaA_yersinia

Family

13

false

This entry represents a group of beta-lactamases from yersinia species, including Beta-lactamase BlaA from Yersinia enterocolitica.

[ "GO:0008800" ]

[ "beta-lactamase activity" ]

[ "molecular_function" ]

1

[ "NCBIFAM" ]

[ "NF033152" ]

[ "BlaA_Yent" ]

[ 13 ]

1

[]

0

[ "8iwv", "9xfw", "9xfx", "9xfy" ]

4

[]

0

[ "IPR000871" ]

[]

1

0

1

[ "Yersinia" ]

[ 13 ]

1

[]

0

true

Family

Beta-lactamase BlaA, yersinia

BlaA_yersinia

1

IPR058203

58,203

Redox-sensing transcriptional repressor Rex, bacilli-type

Rex_bacilli-type

Family

2,615

false

This entry represents Redox-sensing transcriptional repressor Rex from Streptococcus pneumoniae and similar sequences from bacillales and lactobacillales. Rex modulates transcription in response to changes in cellular NADH/NAD+ redox state and binds to the promoter of the aldehyde-alcohol dehydrogenase adhE gene [ ].

[]

0

[ "NCBIFAM" ]

[ "NF003991" ]

[ "PRK05472.1-5" ]

[ 2615 ]

1

[]

0

[ "2vt2", "2vt3", "3keo", "3keq", "3ket" ]

5

[ "PUB00160990" ]

[ "25312953" ]

[ "Ethanol-induced alcohol dehydrogenase E (AdhE) potentiates pneumolysin in Streptococcus pneumoniae." ]

[ 2015 ]

1

[ "IPR022876" ]

[ "IPR058133" ]

1

0

[ "Bacteria", "bioreactor metagenome" ]

[ 2611, 4 ]

2

[]

0

true

Family

Redox-sensing transcriptional repressor Rex, bacilli-type

Rex_bacilli-type

1

IPR058204

58,204

Cell division protein FtsX, firmicutes-type

FtsX_firmicutes-type

Family

4,161

false

This entry represents Cell division protein FtsX and similar proteins predominantly found in firmicutes, including FtsX from Streptococcus pneumoniae, which is required in maintaining normal growth and cellular morphology [ ]. This protein is part of the ABC transporter FtsEX complex that is involved in asymmetric cell...

[]

0

[ "NCBIFAM" ]

[ "NF038347" ]

[ "FtsX_Gpos" ]

[ 4161 ]

1

[]

0

[]

0

[ "PUB00059297", "PUB00097511", "PUB00105736", "PUB00161033" ]

[ "18573177", "32873757", "21949405", "30696736" ]

[ "The FtsEX ABC transporter directs cellular differentiation in Bacillus subtilis.", "Structural Characterization of the Essential Cell Division Protein FtsE and Its Interaction with FtsX in Streptococcus pneumoniae.", "Identification of the bacterial protein FtsX as a unique target of chemokine-mediated antimic...

[ 2008, 2020, 2011, 2019 ]

4

[ "IPR004513" ]

[]

1

0

1

[ "Bacteria", "Eukaryota", "Siphoviridae sp. ctXQ92", "metagenomes" ]

[ 4125, 2, 1, 33 ]

4

[]

0

true

Family

Cell division protein FtsX, firmicutes-type

FtsX_firmicutes-type

9

IPR058205

58,205

D-lactate dehydrogenase-like

D-LDH-like

Family

12,655

false

This protein family includes D-lactate dehydrogenase from Escherichia coli (D-LDH), D-specific alpha-keto acid dehydrogenase from Enterococcus faecium (VanH), Aromatic 2-oxoacid reductase from Clostridium sporogenes (FldH) and similar sequences from all cellular organisms. D-LDH is a fermentative lactate dehydrogenase ...

[ "GO:0008720" ]

[ "D-lactate dehydrogenase (NAD+) activity" ]

[ "molecular_function" ]

1

[ "PANTHER" ]

[ "PTHR43026" ]

[ "" ]

[ 12655 ]

1

[ "EC", "EC", "METACYC", "METACYC", "METACYC", "METACYC" ]

[ "1.1.1", "1.1.1.28", "PWY-6454", "PWY-6901", "PWY-8188", "PWY-8274" ]

[ "EC:1.1.1", "EC:1.1.1.28", "METACYC:PWY-6454", "METACYC:PWY-6901", "METACYC:PWY-8188", "METACYC:PWY-8274" ]

6

[ "1dxy", "1j49", "1j4a", "1xdw", "2dld", "2yq4", "2yq5", "3kb6", "3wx0", "4cuj", "4cuk", "4prk", "4prl", "4xkj", "4zgs", "5z1z", "5z20", "5z21", "6abi", "6abj", "7jp2", "7wn9", "8grv", "8i5z" ]

24

[ "PUB00035620", "PUB00161013", "PUB00161034", "PUB00161035", "PUB00161036", "PUB00161037" ]

[ "10849007", "1931965", "1503450", "1522072", "4297265", "9605319" ]

[ "The involvement of coenzyme A esters in the dehydration of (R)-phenyllactate to (E)-cinnamate by Clostridium sporogenes.", "Molecular basis for vancomycin resistance in Enterococcus faecium BM4147: biosynthesis of a depsipeptide peptidoglycan precursor by vancomycin resistance proteins VanH and VanA.", "Eviden...

[ 2000, 1991, 1992, 1992, 1968, 1998 ]

6

[]

[ "IPR058206" ]

0

1

0

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 21, 11243, 1301, 6, 84 ]

5

[ "Escherichia coli (strain K12)", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 1, 2 ]

3

true

Family

D-lactate dehydrogenase-like

D-LDH-like

4

IPR058206

58,206

D-specific alpha-keto acid dehydrogenase

VanH

Family

169

false

This protein family includes D-specific alpha-keto acid dehydrogenase from Enterococcus faecium (VanH) and similar bacterial sequences. VanH catalyses the reduction of 2-keto acids to 2-D-hydroxy acids, exhibiting highest catalytic efficiency with pyruvate and 2-oxobutanoate/alpha-ketobutyrate as substrates, producing ...

[ "GO:0008720" ]

[ "D-lactate dehydrogenase (NAD+) activity" ]

[ "molecular_function" ]

1

[ "NCBIFAM" ]

[ "NF000492" ]

[ "vanH_gen" ]

[ 169 ]

1

[]

0

[]

0

[ "PUB00161013", "PUB00161034", "PUB00161035", "PUB00161037" ]

[ "1931965", "1503450", "1522072", "9605319" ]

[ "Molecular basis for vancomycin resistance in Enterococcus faecium BM4147: biosynthesis of a depsipeptide peptidoglycan precursor by vancomycin resistance proteins VanH and VanA.", "Evidence for in vivo incorporation of D-lactate into peptidoglycan precursors of vancomycin-resistant enterococci.", "The cytoplas...

[ 1991, 1992, 1992, 1998 ]

4

[ "IPR058205" ]

[]

1

0

1

[ "Bacillati", "prokaryotic environmental samples" ]

[ 167, 2 ]

2

[]

0

true

Family

D-specific alpha-keto acid dehydrogenase

VanH

8

IPR058207

58,207

PID-CTERM protein-sorting domain

PID_CTERM

Domain

531

false

This domain is found in uncharacterised proteins mainly from Gram-negative bacteria. It is located at the C terminus and it is presumably involved in protein sorting.

[]

0

[ "NCBIFAM", "PFAM" ]

[ "NF046080", "PF28310" ]

[ "PID_CTERM", "PID_CTERM" ]

[ 503, 493 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Russula earlei", "ecological metagenomes" ]

[ 526, 3, 2 ]

3

[]

0

true

Domain

PID-CTERM protein-sorting domain

PID_CTERM

6

IPR058208

58,208

PACE efflux transporter

PACE

Family

5,377

false

This entry represents PACE transporters mainly from proteobacteria, including Short-chain diamines transporter from Acinetobacter baumannii, which mediates the efflux of short-chain diamines when energised by an electrochemical gradient [ ]. It is also involved in resistance to the synthetic biocide chlorhexidine, a wi...

[]

0

[ "NCBIFAM" ]

[ "NF033664" ]

[ "PACE_transport" ]

[ 5377 ]

1

[]

0

[]

0

[ "PUB00075703", "PUB00105225", "PUB00105226", "PUB00161044" ]

[ "24277845", "25670776", "29063140", "31416917" ]

[ "Transcriptomic and biochemical analyses identify a family of chlorhexidine efflux proteins.", "Homologs of the Acinetobacter baumannii AceI transporter represent a new family of bacterial multidrug efflux systems.", "Biocide Selective TolC-Independent Efflux Pumps in Enterobacteriaceae.", "Short-chain diamin...

[ 2013, 2015, 2018, 2019 ]

4

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 5356, 5, 16 ]

3

[]

0

true

Family

PACE efflux transporter

PACE

8

IPR058209

58,209

Serine/threonine-protein kinase BSK1-like, TPR repeats

TPR_BSK1_C

Domain

6,603

false

This region of tetratricopeptide (TPR)-like repeats is found at the C-terminal end of Serine/threonine-protein kinase BSK1 from Arabidopsis thaliana and similar eukaryotic proteins. BSK1 acts as a positive regulator of brassinosteroid signalling downstream of the receptor kinase BRI1 [ , ]. This region is also found at...

[]

0

[ "PFAM" ]

[ "PF25575" ]

[ "TPR_BSK1_C" ]

[ 6603 ]

1

[ "EC", "REACTOME", "REACTOME", "REACTOME" ]

[ "2.7.11.1", "R-DDI-3371497", "R-SCE-3371497", "R-SCE-9696273" ]

[ "EC:2.7.11.1", "REACTOME:R-DDI-3371497", "REACTOME:R-SCE-3371497", "REACTOME:R-SCE-9696273" ]

4

[]

0

[ "PUB00001313", "PUB00032225", "PUB00039765", "PUB00039860", "PUB00099081", "PUB00161045" ]

[ "9482716", "15577939", "16531226", "16307917", "23532072", "8653891" ]

[ "The structure of the tetratricopeptide repeats of protein phosphatase 5: implications for TPR-mediated protein-protein interactions.", "Molecular basis for TPR domain-mediated regulation of protein phosphatase 5.", "Conformational diversity in the TPR domain-mediated interaction of protein phosphatase 5 with H...

[ 1998, 2005, 2006, 2005, 2013, 1996 ]

6

[]

0

null

[ "Eukaryota" ]

[ 6603 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Zea mays" ]

[ 58, 30, 1, 84 ]

4

true

Domain

Serine/threonine-protein kinase BSK1-like, TPR repeats

TPR_BSK1_C

4

IPR058210

58,210

Sacsin/Nov domain

SACS/Nov_dom

Domain

9,934

false

This domain is found three times in human Sacsin (SACS) and similar proteins mainly found in eukaryotes. SACS is a co-chaperone which acts as a regulator of the Hsp70 chaperone machinery and may be involved in the processing of other ataxia-linked proteins [ ]. This domain is also found once in Protein NO VEIN from Ara...

[]

0

[ "PFAM" ]

[ "PF25794" ]

[ "SACS" ]

[ 9934 ]

1

[]

0

[ "5v44", "5v45", "5v46", "5v47" ]

4

[ "PUB00019425", "PUB00022756", "PUB00036417", "PUB00038620", "PUB00039730", "PUB00085159", "PUB00097628", "PUB00140138", "PUB00160673", "PUB00161046" ]

[ "9230303", "12970348", "9925731", "15951571", "15955698", "15266054", "20729639", "19208651", "29945973", "19880797" ]

[ "Identification and structural characterization of the ATP/ADP-binding site in the Hsp90 molecular chaperone.", "Structure of the N-terminal domain of GRP94. Basis for ligand specificity and regulation.", "Structural basis for inhibition of the Hsp90 molecular chaperone by the antitumor antibiotics radicicol an...

[ 1997, 2003, 1999, 2005, 2005, 2004, 2010, 2009, 2018, 2009 ]

10

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "metagenomes" ]

[ 31, 478, 9413, 12 ]

4

[ "Arabidopsis thaliana", "Danio rerio", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 17, 6, 14, 6, 1, 16, 7, 22 ]

8

true

Domain

Sacsin/Nov domain

SACS/Nov_dom

8

IPR058211

58,211

Regulatory protein VanR-like

VanR-like

Family

782

false

This entry includes Regulatory protein VanR from Enterococcus faecium and similar proteins from firmicutes. VanR is a member of the two-component regulatory system VanS/VanR [ ]. It binds to the promoter regions of target genes [ , ] and activates the transcription of vanH, vanA and vanX in response to vancomycin which...

[ "GO:0000160", "GO:0006355" ]

[ "phosphorelay signal transduction system", "regulation of DNA-templated transcription" ]

[ "biological_process", "biological_process" ]

2

[ "NCBIFAM" ]

[ "NF033117" ]

[ "vanR_ACDEGLN" ]

[ 782 ]

1

[]

0

[]

0

[ "PUB00161047", "PUB00161048", "PUB00161049", "PUB00161050" ]

[ "1320585", "1556077", "8494882", "8664263" ]

[ "Insertional inactivation of a gene which controls expression of vancomycin resistance on plasmid pHKK100.", "The VanS-VanR two-component regulatory system controls synthesis of depsipeptide peptidoglycan precursors in Enterococcus faecium BM4147.", "Purification and characterization of VanR and the cytosolic d...

[ 1992, 1992, 1993, 1996 ]

4

[ "IPR039420" ]

[ "IPR058234" ]

1

0

[ "Bacillati", "unclassified sequences" ]

[ 780, 2 ]

2

[]

0

true

Family

Regulatory protein VanR-like

VanR-like

2

IPR058212

58,212

Sensor protein VanS-like

VanS-like

Family

273

false

This entry includes Sensor protein VanS from Enterococcus faecium and similar proteins from firmicutes. VanS is a member of the two-component regulatory system VanS/VanR [ ] that functions as a sensor protein kinase which is autophosphorylated at a histidine residue in response to environmental stimuli, such as glycope...

[]

0

[ "NCBIFAM" ]

[ "NF033091" ]

[ "HK_VanS_ACDEFG" ]

[ 273 ]

1

[]

0

[]

0

[ "PUB00161048", "PUB00161049", "PUB00161050", "PUB00161051", "PUB00161052", "PUB00161053", "PUB00161054", "PUB00161055" ]

[ "1556077", "8494882", "8664263", "28511809", "30677074", "8161518", "8981985", "9294451" ]

[ "The VanS-VanR two-component regulatory system controls synthesis of depsipeptide peptidoglycan precursors in Enterococcus faecium BM4147.", "Purification and characterization of VanR and the cytosolic domain of VanS: a two-component regulatory system required for vancomycin resistance in Enterococcus faecium BM4...

[ 1992, 1993, 1996, 2017, 2019, 1994, 1997, 1997 ]

8

[ "IPR050351" ]

[]

1

0

1

[ "Bacillota", "bioreactor metagenome" ]

[ 272, 1 ]

2

[]

0

true

Family

Sensor protein VanS-like

VanS-like

3

IPR058213

58,213

D-alanyl-D-alanine dipeptidase, actinomycetes/firmicutes

VanX_actinomycetes/firmicutes

Family

450

false

This family includes D-alanyl-D-alanine dipeptidase from Enterococcus faecium and similar proteins from actinomycetes and firmicutes. This protein is also known as the vancomycin resistance protein VanX, and hydrolyses D-ala-D-ala [ , ].

[ "GO:0006508" ]

[ "proteolysis" ]

[ "biological_process" ]

1

[ "NCBIFAM" ]

[ "NF033115" ]

[ "dipept_VanX" ]

[ 450 ]

1

[ "EC", "METACYC", "METACYC" ]

[ "3.4.13.22", "PWY-6454", "PWY-6455" ]

[ "EC:3.4.13.22", "METACYC:PWY-6454", "METACYC:PWY-6455" ]

3

[ "1r44", "8xz2" ]

2

[ "PUB00027914", "PUB00027959" ]

[ "7873524", "7854121" ]

[ "Overexpression, purification, and characterization of VanX, a D-, D-dipeptidase which is essential for vancomycin resistance in Enterococcus faecium BM4147.", "Glycopeptide resistance mediated by enterococcal transposon Tn1546 requires production of VanX for hydrolysis of D-alanyl-D-alanine." ]

[ 1995, 1994 ]

2

[ "IPR000755" ]

[]

1

0

1

[ "Bacteria", "unclassified sequences" ]

[ 446, 4 ]

2

[]

0

true

Family

D-alanyl-D-alanine dipeptidase, actinomycetes/firmicutes

VanX_actinomycetes/firmicutes

7

IPR058215

58,215

Beta-lactamase OXA-58-like

OXA-58-like

Family

42

false

This entry represents Beta-lactamase OXA-58 from Acinetobacter baumannii and similar sequences. OXA-58 is a class D beta-lactamase that confers resistance to the beta-lactam antibiotics, including penicillins and oxacillin, and moderate resistance to carbapenems such as imipenem [ ] acting via hydrolysis of the beta-la...

[ "GO:0008800" ]

[ "beta-lactamase activity" ]

[ "molecular_function" ]

1

[ "NCBIFAM" ]

[ "NF000500" ]

[ "blaOXA-58_like" ]

[ 42 ]

1

[]

0

[ "4oh0", "4y0o", "4y0t", "4y0u", "4z9q", "7vx3", "7vx6", "9d79", "9d7a", "9d7b", "9d7c", "9d7d", "9d8c" ]

13

[ "PUB00161067", "PUB00161068", "PUB00161069" ]

[ "15616297", "26459904", "26701320" ]

[ "OXA-58, a novel class D {beta}-lactamase involved in resistance to carbapenems in Acinetobacter baumannii.", "Active-Site Plasticity Is Essential to Carbapenem Hydrolysis by OXA-58 Class D β-Lactamase of Acinetobacter baumannii.", "Crystal Structure of OXA-58 with the Substrate-Binding Cleft in a Closed State:...

[ 2005, 2016, 2015 ]

3

[ "IPR050515" ]

[]

1

0

1

[ "Gammaproteobacteria" ]

[ 42 ]

1

[]

0

true

Family

Beta-lactamase OXA-58-like

OXA-58-like

5

IPR058216

58,216

Regulatory protein VanRB

VanRB

Family

14

false

Members of this family are the response regulator VanR of VanB-type vancomycin resistance systems, including Regulatory protein VanRB from Enterococcus faecalis [ , , ].

[]

0

[ "NCBIFAM" ]

[ "NF000402" ]

[ "vanR-B" ]

[ 14 ]

1

[]

0

[]

0

[ "PUB00008189", "PUB00161070", "PUB00161071" ]

[ "8631706", "10463151", "9751771" ]

[ "Regulation of VanB-type vancomycin resistance gene expression by the VanS(B)-VanR (B) two-component regulatory system in Enterococcus faecalis V583.", "Regulated interactions between partner and non-partner sensors and response regulators that control glycopeptide resistance gene expression in enterococci.", "...

[ 1996, 1999, 1998 ]

3

[ "IPR039420" ]

[]

1

0

1

[ "Bacillati" ]

[ 14 ]

1

[]

0

true

Family

Regulatory protein VanRB

VanRB

5

IPR058217

58,217

Sensor protein VanSB

VanSB

Family

21

false

This family includes Sensor protein VanSB from Enterococcus faecalis and related proteins. VanSB is a member of the two-component regulatory system VanSB/VanRB that activates the transcription of vanSB, vanYB and vanW in response to vancomycin which results in vancomycin resistance [ , , ].

[ "GO:0000155", "GO:0007165" ]

[ "phosphorelay sensor kinase activity", "signal transduction" ]

[ "molecular_function", "biological_process" ]

2

[ "NCBIFAM" ]

[ "NF033090" ]

[ "HK_VanS_B" ]

[ 21 ]

1

[]

0

[]

0

[ "PUB00008189", "PUB00161070", "PUB00161071" ]

[ "8631706", "10463151", "9751771" ]

[ "Regulation of VanB-type vancomycin resistance gene expression by the VanS(B)-VanR (B) two-component regulatory system in Enterococcus faecalis V583.", "Regulated interactions between partner and non-partner sensors and response regulators that control glycopeptide resistance gene expression in enterococci.", "...

[ 1996, 1999, 1998 ]

3

[ "IPR050351" ]

[]

1

0

1

[ "Bacillati" ]

[ 21 ]

1

[]

0

true

Family

Sensor protein VanSB

VanSB

3

IPR058218

58,218

Beta-lactamase OXA-48-like

OXA-48-like

Family

130

false

This entry represents Beta-lactamase OXA-48 from Klebsiella pneumoniae and similar proteins from gammaproteobacteria. OXA-48 confers resistance to the beta-lactam antibiotics, including amoxicillin, and moderate resistance to cephalosporins and carbapenems such as cephalothin and imipenem [ ], via hydrolysis of the bet...

[ "GO:0008658", "GO:0008800" ]

[ "penicillin binding", "beta-lactamase activity" ]

[ "molecular_function", "molecular_function" ]

2

[ "NCBIFAM" ]

[ "NF000387" ]

[ "blaOXA-48_like" ]

[ 130 ]

1

[]

0

[ "3hbr", "4s2j", "4s2k", "4s2n", "4s2p", "5dtk", "5dts", "5dtt", "5dva", "5oe0", "5oe2", "6p96", "6p97", "6p98", "6p99", "6p9c", "6pxx", "6q5b", "6q5f", "6zrj", "6zrp", "6zxi", "7ass", "7dml", "7lxg", "7nrj", "7o5n", "7o5q", "7o5t", "7o9n", "7peh", "7pep"...

43

[ "PUB00052259", "PUB00104012", "PUB00161078", "PUB00161079", "PUB00161080" ]

[ "19477418", "33753332", "14693513", "27073009", "38161376" ]

[ "Crystal structure of the OXA-48 beta-lactamase reveals mechanistic diversity among class D carbapenemases.", "Antimicrobial Resistance Conferred by OXA-48 β-Lactamases: Towards a Detailed Mechanistic Understanding.", "Emergence of oxacillinase-mediated resistance to imipenem in Klebsiella pneumoniae.", "Remo...

[ 2009, 2021, 2004, 2016, 2023 ]

5

[ "IPR050515" ]

[]

1

0

1

[ "Gammaproteobacteria" ]

[ 130 ]

1

[]

0

true

Family

Beta-lactamase OXA-48-like

OXA-48-like

9

IPR058219

58,219

LiaX

Family

336

false

LiaX (lipid-II-interacting antibiotics X), as described in Enterococcus faecalis, is expressed under control of the the LiaR response regulator, and is involved in the process of resistance to daptomycin and to antimicrobial peptides of the innate immune response. It is involved in cell membrane remodelling, regulating...

[]

0

[ "NCBIFAM" ]

[ "NF038025" ]

[ "dapto_LiaX" ]

[ 336 ]

1

[]

0

[]

0

[ "PUB00105524" ]

[ "31818937" ]

[ "Antimicrobial sensing coupled with cell membrane remodeling mediates antibiotic resistance and virulence in Enterococcus faecalis." ]

[ 2019 ]

1

[]

0

null

[ "Lactobacillales", "bioreactor metagenome" ]

[ 334, 2 ]

2

[]

0

true

Family

LiaX

1

IPR058220

58,220

Carbapenem-hydrolyzing beta-lactamase KPC-2/ Beta-lactamase SME-1-like

KPC-2/SME-1-like

Family

364

false

This entry represents a group of beta-lactamases mainly found in enterobacterales, including Carbapenem-hydrolyzing beta-lactamase KPC-2 from Klebsiella pneumoniae and Beta-lactamase SME-1 from Serratia marcescens. These proteins confer resistance to the beta-lactam antibiotics, including penicillins, cephalosporins an...

[ "GO:0008800" ]

[ "beta-lactamase activity" ]

[ "molecular_function" ]

1

[ "NCBIFAM" ]

[ "NF000538" ]

[ "classA_carba" ]

[ 364 ]

1

[ "EC", "REACTOME" ]

[ "3.5.2.6", "R-HSA-9913143" ]

[ "EC:3.5.2.6", "REACTOME:R-HSA-9913143" ]

2

[ "1bue", "1bul", "1dy6", "2ov5", "3c5a", "3dw0", "3e2k", "3e2l", "3rxw", "3rxx", "4eqi", "4euz", "4ev4", "4zbe", "5eec", "5ll7", "5mgi", "5uj3", "5uj4", "5ul8", "6b1f", "6b1h", "6b1j", "6b1w", "6b1x", "6b1y", "6d15", "6d16", "6d17", "6d18", "6d19", "6dmh"...

123

[ "PUB00161081", "PUB00161082" ]

[ "11257029", "33257320" ]

[ "Novel carbapenem-hydrolyzing beta-lactamase, KPC-1, from a carbapenem-resistant strain of Klebsiella pneumoniae.", "Natural variants modify Klebsiella pneumoniae carbapenemase (KPC) acyl-enzyme conformational dynamics to extend antibiotic resistance." ]

[ 2001, 2021 ]

2

[ "IPR000871" ]

[ "IPR058198" ]

1

0

[ "Bacteria" ]

[ 364 ]

1

[]

0

true

Family

Carbapenem-hydrolyzing beta-lactamase KPC-2/ Beta-lactamase SME-1-like

KPC-2/SME-1-like

5

IPR058221

58,221

Beta-lactamase CMY-1/10

CMY-1/10

Family

114

false

This entry represents a group of beta-lactamases from gammaproteobacteria, including CMY-1 from Klebsiella pneumoniae, CMY-10 from Klebsiella aerogenes. These proteins confer resistance to penicillins and cephalosporins [ , ]. CMY-1 has benzylpenicillin- and cefalotin-hydrolysing activities [ ]. CMY-10 has benzylpenici...

[ "GO:0008800" ]

[ "beta-lactamase activity" ]

[ "molecular_function" ]

1

[ "NCBIFAM" ]

[ "NF012172" ]

[ "FOX-MOX" ]

[ 114 ]

1

[]

0

[ "1zkj", "3w8k", "4wbg", "5cgs", "5cgw", "5cgx", "5chj", "5chm", "5chu", "5f1f", "5gsc", "5k1d", "5k1f", "5za2", "5zyb", "6fm6", "6fm7" ]

17

[ "PUB00038919", "PUB00161084", "PUB00161085", "PUB00161086", "PUB00161087" ]

[ "16677302", "15383166", "16189104", "28242658", "8843306" ]

[ "Structural basis for the extended substrate spectrum of CMY-10, a plasmid-encoded class C beta-lactamase.", "Dissemination of transferable AmpC-type beta-lactamase (CMY-10) in a Korean hospital.", "Kinetic properties of four plasmid-mediated AmpC beta-lactamases.", "GMP and IMP Are Competitive Inhibitors of ...

[ 2006, 2004, 2005, 2017, 1996 ]

5

[ "IPR058136" ]

[]

1

0

1

[ "Bacteria" ]

[ 114 ]

1

[]

0

true

Family

Beta-lactamase CMY-1/10

CMY-1/10

2

IPR058222

58,222

Type III secretion systems effector SseF-like

SseF-like

Family

645

false

This entry represents a group of uncharacterised Type III secretion systems effector SseF proteins from Salmonella species. With SseG, it is involved in the aggregation of the host endosomes [ ].

[]

0

[ "NCBIFAM" ]

[ "NF011885" ]

[ "PRK15358.1" ]

[ 645 ]

1

[]

0

[]

0

[ "PUB00161091" ]

[ "29610274" ]

[ "The Salmonella effectors SseF and SseG inhibit Rab1A-mediated autophagy to facilitate intracellular bacterial survival and replication." ]

[ 2018 ]

1

[ "IPR060700" ]

[]

1

0

1

[ "Salmonella" ]

[ 645 ]

1

[]

0

true

Family

Type III secretion systems effector SseF-like

SseF-like

9

IPR058223

58,223

Type III secretion system effector SseG-like

SseG-like

Family

483

false

This entry represents a group of uncharacterised type III secretion systems effector SseG proteins, from Salmonella pathogenicity island 2 in Salmonella species. With SseF , it is involved in the aggregation of the host endosomes [ ].

[]

0

[ "NCBIFAM" ]

[ "NF011884" ]

[ "PRK15357.1" ]

[ 483 ]

1

[]

0

[]

0

[ "PUB00104986", "PUB00161091" ]

[ "27406559", "29610274" ]

[ "Salmonella Effectors SseF and SseG Interact with Mammalian Protein ACBD3 (GCP60) To Anchor Salmonella-Containing Vacuoles at the Golgi Network.", "The Salmonella effectors SseF and SseG inhibit Rab1A-mediated autophagy to facilitate intracellular bacterial survival and replication." ]

[ 2016, 2018 ]

2

[ "IPR060700" ]

[]

1

0

1

[ "Salmonella" ]

[ 483 ]

1

[]

0

true

Family

Type III secretion system effector SseG-like

SseG-like

6

IPR058224

58,224

Choice-of-anchor T protein

Choice_anch_T

Family

28

false

Members of this family are found in the predicted proteins of archaeal genomes from metagenome-derived assemblies. Multiple sequence alignment shows that members contain several different classes of short C-terminal putative sorting signals.

[]

0

[ "NCBIFAM" ]

[ "NF041740" ]

[ "choice_anch_T" ]

[ 28 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Methanobacteriati", "marine metagenome", "uncultured Rhodobacterales bacterium HF0010_04M21" ]

[ 16, 11, 1 ]

3

[]

0

true

Family

Choice-of-anchor T protein

Choice_anch_T

6

IPR058225

58,225

Periplasmic-type flagellar collar protein FlbB-like

FlbB-like

Family

260

false

This family, specific to Spirochaetota, includes the collar protein FlbB of periplasmic-type ( , BB_0286) flagella [ ]. Note that the term FlbB is used in other lineages to describe a flagellar transcriptional activator unrelated to this protein.

[]

0

[ "NCBIFAM" ]

[ "NF047368" ]

[ "collar_FlbB" ]

[ 260 ]

1

[]

0

[]

0

[ "PUB00159572" ]

[ "27416872" ]

[ "Spirochetes flagellar collar protein FlbB has astounding effects in orientation of periplasmic flagella, bacterial shape, motility, and assembly of motors in Borrelia burgdorferi." ]

[ 2016 ]

1

[]

0

null

[ "Bacteria" ]

[ 260 ]

1

[]

0

true

Family

Periplasmic-type flagellar collar protein FlbB-like

FlbB-like

4

IPR058226

58,226

Cell surface glycopolymer formation protein AZOBR_p60025-like

AZOBR_p60025-like

Family

252

false

Members of this baterial family, including AZOBR_p60025 from a plasmid of Azospirillum brasilense ( ), are thought to be membrane proteins of surface polysaccharide biosynthesis. AZOBR_p60025 has been reported to be essential for the decoration of the cell surface with LPSII and CBPS (Calcofluor-binding polysaccharides...

[]

0

[ "NCBIFAM" ]

[ "NF046093" ]

[ "AZOBR_p60025_fam" ]

[ 252 ]

1

[]

0

[]

0

[ "PUB00159562" ]

[ "32607666" ]

[ "Plasmid gene for putative integral membrane protein affects formation of lipopolysaccharide and motility in Azospirillum brasilense Sp245." ]

[ 2020 ]

1

[]

0

null

[ "Bacteria", "hydrothermal vent metagenome" ]

[ 251, 1 ]

2

[]

0

true

Family

Cell surface glycopolymer formation protein AZOBR_p60025-like

AZOBR_p60025-like

8

IPR058227

58,227

RSP_7527-like

Family

293

false

This entry represents a group of uncharacterised proteins from proteobacteria, including the hypothetical protein RSP_7527 from the facultative phototrophic Rhodobacter sphaeroides ( ), which is notable because a 67 nucleotide small structural RNA, UdsC (UTR-derived sRNA C), derives from the 3'-untranslated region of i...

[]

0

[ "NCBIFAM" ]

[ "NF046098" ]

[ "RSP_7527_fam" ]

[ 293 ]

1

[]

0

[]

0

[ "PUB00159102", "PUB00159103", "PUB00159104" ]

[ "30456366", "34830143", "36555125" ]

[ "RNase E cleavage shapes the transcriptome of Rhodobacter sphaeroides and strongly impacts phototrophic growth.", "Maturation of UTR-Derived sRNAs Is Modulated during Adaptation to Different Growth Conditions.", "A Small RNA, UdsC, Interacts with the RpoHII mRNA and Affects the Motility and Stress...

[ 2018, 2021, 2022 ]

3

[]

0

null

[ "Pseudomonadota", "marine sediment metagenome" ]

[ 292, 1 ]

2

[]

0

true

Family

RSP_7527-like

2

IPR058228

58,228

Surface attachment protein Sap1

Sap1

Family

262

false

This entry represents a group of uncharacterised proteins from Burkholderiales, including the surface attachment protein 1 from Burkholderia pseudomallei (BP1026B_I0091, ), a virulence factor important for attachment to host cells [ , ].

[]

0

[ "NCBIFAM", "PFAM" ]

[ "NF046013", "PF28314" ]

[ "surf_attach_Sap1", "Sap1" ]

[ 254, 262 ]

2

[]

0

[]

0

[ "PUB00159059", "PUB00159060" ]

[ "33772012", "36726566" ]

[ "The Burkholderia pseudomallei intracellular 'TRANSITome'.", "A virulence activator of a surface attachment protein in Burkholderia pseudomallei acts as a global regulator of other membrane-associated virulence factors." ]

[ 2021, 2022 ]

2

[]

0

null

[ "Pseudomonadota" ]

[ 262 ]

1

[]

0

true

Family

Surface attachment protein Sap1

Sap1

7

IPR058230

58,230

Surface protein adhesin OmpL37

OmpL37

Family

300

false

Members of this family of major outer membrane proteins are found in Leptospira species, where from one to three paralogs are seen per proteome. In Leptospira interrogans, the family includes two paralogs, LIC_12263, which is the adhesin OmpL37 ( ), and LIC_10262 ( ), which is uncharacterised. OmpL37 interacts with hos...

[]

0

[ "NCBIFAM", "PFAM" ]

[ "NF047447", "PF28315" ]

[ "Lepto_OmpL37", "OmpL37" ]

[ 286, 300 ]

2

[]

0

[]

0

[ "PUB00159260", "PUB00159331", "PUB00159332" ]

[ "19562037", "20844573", "36555188" ]

[ "A comprehensive approach to identification of surface-exposed, outer membrane-spanning proteins of Leptospira interrogans.", "The OmpL37 surface-exposed protein is expressed by pathogenic Leptospira during infection and binds skin and vascular elastin.", "Host Cell Binding Mediated by Leptospira interrogans...

[ 2009, 2010, 2022 ]

3

[]

0

null

[ "Leptospiraceae" ]

[ 300 ]

1

[]

0

true

Family

Surface protein adhesin OmpL37

OmpL37

1

IPR058231

58,231

MG284-like, C-terminal domain

MG284-like_C

Domain

193

false

This entry represents the C-terminal domain of MG284 from Mycoplasma pneumoniae and similar uncharacterised proteins from actinobacteria and firmicutes. The function of this domain is currently unknown.

[]

0

[ "NCBIFAM" ]

[ "NF045770" ]

[ "MPN403_MG284_C" ]

[ 193 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacillati", "bioreactor metagenome" ]

[ 192, 1 ]

2

[]

0

true

Domain

MG284-like, C-terminal domain

MG284-like_C

2

IPR058233

58,233

D,D-carboxypeptidase/D,D-dipeptidase VanXY

VanXY

Family

38

false

This entry represents Bifunctional D-Ala-D-Ala dipeptidase and D-Ala-D-Ala carboxypeptidase VanXYC from Enterococcus gallinarum and similar proteins mainly found in lactobacillales. VanXYC catalyses the hydrolysis of the D-alanyl-D-alanine dipeptideand cleaves the C-terminal D-alanine residue of UDP-muramyl-pentapeptid...

[]

0

[ "NCBIFAM" ]

[ "NF000380" ]

[ "vanXY" ]

[ 38 ]

1

[]

0

[ "4f78", "4muq", "4mur", "4mus", "4mut", "4oak" ]

6

[ "PUB00140739", "PUB00161014", "PUB00161095", "PUB00161096" ]

[ "24711382", "15728903", "10564477", "10817725" ]

[ "Structural basis for the evolution of vancomycin resistance D,D-peptidases.", "Transcriptional analysis of the vanC cluster from Enterococcus gallinarum strains with constitutive and inducible vancomycin resistance.", "Gene vanXYC encodes D,D -dipeptidase (VanX) and D,D-carboxypeptidase (VanY) activities in va...

[ 2014, 2005, 1999, 2000 ]

4

[ "IPR052179" ]

[]

1

0

1

[ "Bacilli" ]

[ 38 ]

1

[]

0

true

Family

D,D-carboxypeptidase/D,D-dipeptidase VanXY

VanXY

5

IPR058234

58,234

Regulatory protein VanRc

VanRc

Family

14

false

Members of this family are the response regulator VanR of VanC-type vancomycin resistance systems. This family is specific to Enterococcus species.

[]

0

[ "NCBIFAM" ]

[ "NF000403" ]

[ "vanR-C" ]

[ 14 ]

1

[]

0

[]

0

[]

0

[ "IPR058211" ]

[]

1

0

1

[ "Enterococcus" ]

[ 14 ]

1

[]

0

true

Family

Regulatory protein VanRc

VanRc

6

IPR058235

58,235

Beta-lactamase OXA-23/133

OXA-23/133

Family

101

false

This entry represents a group of beta-lactamases mainly found in Acinetobacter species, including OXA-23 from A.baumannii and OXA-133 from A.radioresistens [ ]. OXA-23 is a class D beta-lactamase which confers resistance to the beta-lactam antibiotics, including ampicillin, and carbapenems such as imipenem and meropene...

[ "GO:0008658", "GO:0008800" ]

[ "penicillin binding", "beta-lactamase activity" ]

[ "molecular_function", "molecular_function" ]

2

[ "NCBIFAM" ]

[ "NF000266" ]

[ "blaOXA-23_like" ]

[ 101 ]

1

[]

0

[ "9nsw", "9nsx", "9nsy", "9nsz", "9nt0" ]

5

[ "PUB00161097", "PUB00161098", "PUB00161099", "PUB00161100", "PUB00161101", "PUB00161102" ]

[ "18725452", "19015330", "20194701", "24012371", "30530607", "35420470" ]

[ "Genetic basis of multidrug resistance in Acinetobacter baumannii clinical isolates at a tertiary medical center in Pennsylvania.", "Codetection of blaOXA-23-like gene (blaOXA-133) and blaOXA-58 in Acinetobacter radioresistens: report from the SENTRY antimicrobial surveillance program.", "Genetic basis of multi...

[ 2008, 2009, 2010, 2013, 2019, 2022 ]

6

[ "IPR050515" ]

[]

1

0

1

[ "Gammaproteobacteria" ]

[ 101 ]

1

[]

0

true

Family

Beta-lactamase OXA-23/133

OXA-23/133

9

IPR058236

58,236

Redox-sensing transcriptional repressor Rex, actinobacterial-type

Rex_actinobacterial-type

Family

4,433

false

This entry represents Redox-sensing transcriptional repressor Rex from Streptomyces coelicolor and similar sequences mainly found in actinobacteria, but also some species of firmicutes, chloroflexota and other bacteria. Rex modulates the transcription of respiratory genes in response to changes in cellular NADH/NAD+ re...

[]

0

[ "NCBIFAM" ]

[ "NF003993" ]

[ "PRK05472.2-2" ]

[ 4433 ]

1

[]

0

[ "1xcb", "2dt5", "3ikt", "3ikv", "3il2", "3wg9", "3wgg", "3wgh", "3wgi", "5zz5", "5zz6", "5zz7", "7wb3" ]

13

[ "PUB00015140" ]

[ "12970197" ]

[ "A novel sensor of NADH/NAD+ redox poise in Streptomyces coelicolor A3(2)." ]

[ 2003 ]

1

[ "IPR022876" ]

[]

1

0

1

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 4314, 5, 114 ]

3

[]

0

true

Family

Redox-sensing transcriptional repressor Rex, actinobacterial-type

Rex_actinobacterial-type

8

IPR058237

58,237

Metallo-beta-lactamase IND-1

IND-1

Family

74

false

This entry represents a group of beta-lactamases from Chryseobacterium species, including Metallo-beta-lactamase IND-1 from Chryseobacterium indologenes, a class B beta-lactamase which confers resistance to the beta-lactam antibiotics, including penicillins, cephalosporins and carbapenems [ ].

[ "GO:0008800" ]

[ "beta-lactamase activity" ]

[ "molecular_function" ]

1

[ "NCBIFAM" ]

[ "NF012149" ]

[ "blaIND" ]

[ 74 ]

1

[]

0

[ "3l6n" ]

1

[ "PUB00161103" ]

[ "10077836" ]

[ "Molecular characterization of a carbapenem-hydrolyzing beta-lactamase from Chryseobacterium (Flavobacterium) indologenes." ]

[ 1999 ]

1

[ "IPR058199" ]

[]

1

0

1

[ "Chryseobacterium" ]

[ 74 ]

1

[]

0

true

Family

Metallo-beta-lactamase IND-1

IND-1

3

IPR058238

58,238

Class I lanthipeptide leader domain

Lant_leader_dom

Domain

1,072

false

This entry represents a homology domain found regularly as a leader peptide, ending with a GlyGly dipeptide (a leader peptide cleavage site), of putative lanthipeptides (probably lantibiotics in most cases) encoded in the vicinity of a class I lanthionine synthase, or LanC. The designation L1a reflects model constructi...

[]

0

[ "NCBIFAM" ]

[ "NF038153" ]

[ "lant_leader_L1a" ]

[ 1072 ]

1

[]

0

[]

0

[ "PUB00105579" ]

[ "32493223" ]

[ "Precursor peptide-targeted mining of more than one hundred thousand genomes expands the lanthipeptide natural product family." ]

[ 2020 ]

1

[]

0

null

[ "Bacteria", "Symbiodinium", "bioreactor metagenome" ]

[ 1069, 2, 1 ]

3

[]

0

true

Domain

Class I lanthipeptide leader domain

Lant_leader_dom

5

IPR058239

58,239

Inner membrane protein, putative, salmonella

Inner_memb_put_salmonella

Family

339

false

This entry represents a group of uncharacterised proteins from Salmonella species. Most members are annotated as inner membrane proteins.

[]

0

[ "NCBIFAM" ]

[ "NF007301" ]

[ "PRK09781.1" ]

[ 339 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Salmonella" ]

[ 339 ]

1

[]

0

true

Family

Inner membrane protein, putative, salmonella

Inner_memb_put_salmonella

9

IPR058240

58,240

Radical SAM superfamily

rSAM_sf

Homologous_superfamily

468,679

false

This superfamily represents the radical SAM domain, which is organised in a fold related to the β-barrel or TIM barrel, in which β-strands are arranged in a barrel-like array, with peripheral helices intervening between β-strands. The [4Fe-4S] clusters and substrates are bound within the barrels, as is typical of TIM b...

[]

0

[ "SSF" ]

[ "SSF102114" ]

[ "" ]

[ 468679 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-947581", "R-BTA-9857492", "R-DDI-947581", "R-DME-947581", "R-DME-9857492", "R-DRE-9857492", "R-HSA-3214847", "R-HSA-6782315", "R-HSA-6782861", "R-HSA-909733", "R-HSA-947581", "R-HSA-9857492", "R-MMU-947581", "R-MMU-9857492", "R-RNO-9857492" ]

[ "REACTOME:R-BTA-947581", "REACTOME:R-BTA-9857492", "REACTOME:R-DDI-947581", "REACTOME:R-DME-947581", "REACTOME:R-DME-9857492", "REACTOME:R-DRE-9857492", "REACTOME:R-HSA-3214847", "REACTOME:R-HSA-6782315", "REACTOME:R-HSA-6782861", "REACTOME:R-HSA-909733", "REACTOME:R-HSA-947581", "REACTOME:R-H...

15

[ "1olt", "1r30", "1tv7", "1tv8", "2a5h", "2fb2", "2fb3", "2qgq", "2y7d", "2y7e", "2y7f", "2y7g", "2yx0", "2z2u", "3c8f", "3can", "3cb8", "3ciw", "3cix", "3iix", "3iiz", "3lot", "3rf9", "3rfa", "3t7v", "4jc0", "4jxc", "4jy8", "4jy9", "4jyd", "4jye", "4jyf"...

170

[ "PUB00010539", "PUB00015124", "PUB00065909", "PUB00097555", "PUB00097556", "PUB00097557" ]

[ "11222759", "15317939", "22761404", "18307109", "22579873", "28893989" ]

[ "Radical SAM, a novel protein superfamily linking unresolved steps in familiar biosynthetic pathways with radical mechanisms: functional characterization using new analysis and information visualization methods.", "Crystal structure of the S-adenosylmethionine-dependent enzyme MoaA and its implications for molybd...

[ 2001, 2004, 2012, 2008, 2012, 2017 ]

6

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 19090, 398706, 37987, 1247, 11649 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus",...

[ 48, 8, 16, 5, 20, 41, 18, 8, 39, 34, 4, 4, 96 ]

13

true

Homologous_superfamily

Radical SAM superfamily

rSAM_sf

7

IPR058241

58,241

Lysostaphin, N-terminal domain

Lysostaphin_N

Domain

78

false

This entry represents a domain found toward the N-terminal end of lysostaphin from Staphylococcus simulans, an extracellular glycylglycine endopeptidase that lyses staphylococcal cells by hydrolysing the polyglycine interpeptide bridges of the peptidoglycan [ , ]. This domain contains a repeated semi-conserved SHxxV[ED...

[]

0

[ "PFAM" ]

[ "PF25533" ]

[ "Lysostaphin_N" ]

[ 78 ]

1

[]

0

[ "6rk4" ]

1

[ "PUB00101294", "PUB00101295" ]

[ "30018958", "31686030" ]

[ "Structural and Functional Insights Into Lysostaphin-Substrate Interaction.", "Two-site recognition of Staphylococcus aureus peptidoglycan by lysostaphin SH3b." ]

[ 2018, 2020 ]

2

[]

0

null

[ "Opisthokonta", "Staphylococcus simulans" ]

[ 75, 3 ]

2

[]

0

true

Domain

Lysostaphin, N-terminal domain

Lysostaphin_N

3

IPR058242

58,242

Capsid protein, partitivirus

Capsid_partitivirus

Family

121

false

This entry represents the capsid protein of partitiviruses. The capsid protein self-assembles to form an icosahedral capsid with a T=2 symmetry made of 120 subunits. In partitiviruses, one dsRNA segment typically encodes the viral RNA-dependent RNA polymerase, while the second segment encodes the capsid protein. The Pa...

[]

0

[ "PFAM" ]

[ "PF25666" ]

[ "Partiti_capsid" ]

[ 121 ]

1

[]

0

[ "8phh" ]

1

[ "PUB00160650" ]

[ "7782774" ]

[ "Genome organization of a partitivirus from the filamentous ascomycete Atkinsonella hypoxylon." ]

[ 1995 ]

1

[]

0

null

[ "Eukaryota", "unclassified Partitiviridae" ]

[ 29, 92 ]

2

[]

0

true

Family

Capsid protein, partitivirus

Capsid_partitivirus

5

IPR058244

58,244

DNA-binding transcriptional activator EvgA

EvgA

Family

223

false

This family includes DNA-binding transcriptional activator EvgA from Escherichia coli and similar proteins from enterobacterales. EvgA is a member of the two-component regulatory system EvgS/EvgA [ , , ], which is involved in regulating the expression of glutamate-dependent acid resistance genes, acting in concert with...

[ "GO:0043565" ]

[ "sequence-specific DNA binding" ]

[ "molecular_function" ]

1

[ "NCBIFAM" ]

[ "NF007419" ]

[ "PRK09958.1" ]

[ 223 ]

1

[]

0

[ "3f6c", "5f64", "8zwn" ]

3

[ "PUB00013252", "PUB00075795", "PUB00161565", "PUB00161566", "PUB00161567", "PUB00161568", "PUB00161569", "PUB00161571", "PUB00161572" ]

[ "12694615", "17998538", "10825546", "10923791", "11157960", "11914367", "15489450", "9535079", "12951338" ]

[ "Regulatory network of acid resistance genes in Escherichia coli.", "B1500, a small membrane protein, connects the two-component systems EvgS/EvgA and PhoQ/PhoP in Escherichia coli.", "Dimerization of signalling modules of the EvgAS and BvgAS phosphorelay systems.", "Transcription of emrKY is regulated by the...

[ 2003, 2007, 2000, 2000, 2001, 2002, 2004, 1998, 2003 ]

9

[ "IPR051015" ]

[]

1

0

1

[ "Enterobacterales" ]

[ 223 ]

1

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

DNA-binding transcriptional activator EvgA

EvgA

7

IPR058245

58,245

NreC/VraR/RcsB-like, phosphoacceptor receiver domain

NreC/VraR/RcsB-like_REC

Domain

173,048

false

This entry represents phosphoacceptor receiver (REC) domain of Oxygen regulatory protein NreC and Response regulator protein VraR from Staphylococcus aureus, Transcriptional regulatory protein RcsB from Escherichia coli and similar bacterial regulators. NreC is a member of the two-component regulatory system NreB/NreC ...

[]

0

[ "CDD" ]

[ "cd17535" ]

[ "REC_NarL-like" ]

[ 173048 ]

1

[]

0

[ "2qsj", "3c3w", "3cz5", "3eul", "3f6c", "4gvp", "4if4", "4yn8", "5f64", "5hev", "5i4c", "5o8y", "5o8z", "5vxn", "5w43", "6eo2", "6eo3", "6zii", "6zil", "6zix", "6zj2", "7ve6", "8zwn", "9xzo" ]

24

[ "PUB00007150", "PUB00042647", "PUB00074155", "PUB00074156", "PUB00107921", "PUB00144125", "PUB00161573", "PUB00161574", "PUB00161575" ]

[ "11557134", "10708580", "10702265", "20189963", "26010043", "26307095", "1597415", "31009806", "31214151" ]

[ "Novel domains of the prokaryotic two-component signal transduction systems.", "Identification of the up- and down-regulated genes in vancomycin-resistant Staphylococcus aureus strains Mu3 and Mu50 by cDNA differential hybridization method.", "The RcsAB box. Characterization of a new operator essential for the ...

[ 2001, 2000, 2000, 2010, 2015, 2015, 1992, 2019, 2019 ]

9

[ "IPR001789" ]

[]

1

0

1

[ "Archaea", "Bacteria", "Eukaryota", "Siphoviridae sp. ctBLh2", "unclassified sequences" ]

[ 34, 171746, 113, 1, 1154 ]

5

[ "Escherichia coli (strain K12)" ]

[ 5 ]

1

true

Domain

NreC/VraR/RcsB-like, phosphoacceptor receiver domain

NreC/VraR/RcsB-like_REC

5

IPR058246

58,246

Sensor protein EvgS

EvgS

Family

193

false

This entry represents Sensor protein EvgS from Escherichia coli and similar proteins from enterobacterales. EvgS, a outer membrane protein, is the sensor kinase in a two-component system EvgS/EvgA and is is involved in adaptation to low pH environments and the control of acid resistance genes [ , , , ].

[ "GO:0004673", "GO:0010447" ]

[ "protein histidine kinase activity", "response to acidic pH" ]

[ "molecular_function", "biological_process" ]

2

[ "NCBIFAM" ]

[ "NF007420" ]

[ "PRK09959.1" ]

[ 193 ]

1

[]

0

[]

0

[ "PUB00112343", "PUB00141051", "PUB00159747", "PUB00159748", "PUB00161576" ]

[ "24957621", "24995530", "26151934", "28674068", "29140975" ]

[ "Alkali metals in addition to acidic pH activate the EvgS histidine kinase sensor in Escherichia coli.", "Characterization of mutations in the PAS domain of the EvgS sensor kinase selected by laboratory evolution for acid resistance in Escherichia coli.", "Functional Characterization of the Receiver Domain for ...

[ 2014, 2014, 2015, 2017, 2017 ]

5

[]

0

null

[ "Enterobacterales" ]

[ 193 ]

1

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Sensor protein EvgS

EvgS

8

IPR058247

58,247

CcdC-like

DUF1453

Family

3,199

false

This family includes protein CcdC, csk22 and Uncharacterized protein YxjN from Bacillus subtilis. In Bacillus velezensis, ccdC gene has been found to be involved in the process of biofilm dispersion [ ].

[]

0

[ "PFAM" ]

[ "PF07301" ]

[ "DUF1453" ]

[ 3199 ]

1

[]

0

[]

0

[ "PUB00161579" ]

[ "9068642" ]

[ "Identification and characterization of the ccdA gene, required for cytochrome c synthesis in Bacillus subtilis." ]

[ 1997 ]

1

[]

[ "IPR031306" ]

0

1

0

[ "Archaea", "Bacteria", "Eukaryota", "ecological metagenomes" ]

[ 26, 3166, 2, 5 ]

4

[]

0

true

Family

CcdC-like

DUF1453

5

IPR058248

58,248

Putative lipoprotein Lxx21020-like

Lxx211020-like

Family

13,023

false

This entry represents Putative lipoprotein Lxx21020, Uncharacterized protein RP573 and similar proteins mainly from bacteria.

[]

0

[ "PANTHER" ]

[ "PTHR36302" ]

[ "" ]

[ 13023 ]

1

[]

0

[ "1x9l", "2jqa", "2k6w", "2k6y", "2k6z", "2k70", "3zja", "3zk0", "6p16", "6p17", "6p1e", "6p1f", "6p1g" ]

13

[ "PUB00161580" ]

[ "33042100" ]

[ "Lipoproteins in Gram-Positive Bacteria: Abundance, Function, Fitness." ]

[ 2020 ]

1

[ "IPR007410" ]

[ "IPR021174" ]

1

0

[ "Bacteria", "Eukaryota", "Thermoproteati", "unclassified sequences" ]

[ 12835, 14, 14, 160 ]

4

[]

0

true

Family

Putative lipoprotein Lxx21020-like

Lxx211020-like

5

IPR058249

58,249

Pachytene checkpoint protein 2, C-terminal

Pch2_C

Domain

3,031

false

This domain is found at the C-terminal end of Pch2 and similar eukaryotic proteins. It is normally found associated to and is predicted to show an α-helical configuration. Pachytene checkpoint protein 2 (Pch2, also known as TRIP13) is a member of the AAA-ATPase family, predicted to have ATP binding and ATP hydrolysis a...

[]

0

[ "PFAM" ]

[ "PF23242" ]

[ "AAA_lid_TRIP13_C" ]

[ 3031 ]

1

[]

0

[ "4xgu", "5vq9", "5vqa", "5wc2", "6f0x", "6lk0", "7l9p" ]

7

[ "PUB00096383", "PUB00096384", "PUB00155484", "PUB00155485" ]

[ "10319812", "28553959", "28659378", "29208896" ]

[ "Pch2 links chromatin silencing to meiotic checkpoint control.", "Biallelic TRIP13 mutations predispose to Wilms tumor and chromosome missegregation.", "The AAA+ ATPase TRIP13 remodels HORMA domains through N-terminal engagement and unfolding.", "Mechanistic insight into TRIP13-catalyzed Mad2 structural trans...

[ 1999, 2017, 2017, 2017 ]

4

[]

0

null

[ "Eukaryota" ]

[ 3031 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Zea mays" ]

[ 5, 1, 3, 1, 1, 1, 2, 4, 1, 4 ]

10

true

Domain

Pachytene checkpoint protein 2, C-terminal

Pch2_C

4

IPR058250

58,250

CCC domain

CCC

Domain

342

false

This domain is found in uncharacterised insect proteins. It contains highly conserved cysteine residues, including some arranged in CCC sequence motif after which this domain was named. This CCC-motif is usually repeated twice. These residues are predicted to form disulfide bonds.

[]

0

[ "PFAM" ]

[ "PF26644" ]

[ "CCC" ]

[ 342 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Pterygota" ]

[ 342 ]

1

[ "Drosophila melanogaster" ]

[ 1 ]

1

true

Domain

CCC domain

CCC

6

IPR058251

58,251

Probable treble clef zinc finger

Znf_Tbcl_3

Domain

173

false

This domain is found in uncharacterised fungal proteins. It contains three highly conserved cysteine and histidine residues that may be involved in metal coordination. It probably a variant of treble clef zinc fingers.

[]

0

[ "PFAM" ]

[ "PF26647" ]

[ "zf_Tbcl_3" ]

[ 173 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Fungi" ]

[ 173 ]

1

[]

0

true

Domain

Probable treble clef zinc finger

Znf_Tbcl_3

3

IPR058252

58,252

Probable treble clef zinc finger, fungi

Znf_Tbcl_4

Domain

194

false

This domain is found in uncharacterised fungal proteins. It contains three highly conserved cysteine and histidine residues that may be involved in metal coordination. It is probably a variant of treble clef zinc fingers. This domain is frequently found paired with .

[]

0

[ "PFAM" ]

[ "PF26648" ]

[ "zf_Tbcl_4" ]

[ 194 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "leotiomyceta" ]

[ 194 ]

1

[]

0

true

Domain

Probable treble clef zinc finger, fungi

Znf_Tbcl_4

3

IPR058253

58,253

Probable double zinc ribbon domain

Zn_ribbon_double

Domain

196

false

This domain is found in uncharacterised fungal proteins. It contains four pairs of highly conserved cysteine residues that may be involved in metal coordination. It probably resembles two joined zinc ribbon domains judging by the AlphaFold prediction.

[]

0

[ "PFAM" ]

[ "PF26652" ]

[ "Zn_ribbon_double" ]

[ 196 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Dothideomycetes" ]

[ 196 ]

1

[]

0

true

Domain

Probable double zinc ribbon domain

Zn_ribbon_double

8

IPR058254

58,254

Putative CHCC zinc finger

Znf-CHCC_shd

Domain

141

false

This entry represents a domain found in multiple copies in uncharacterised eukaryotic proteins. In contains invariant cysteine and histidine residues that may be involved in metal coordination. It is predicted to adopt a structure reminiscent of the classical C2H2 zinc fingers and composed of β-hairpin and α-helix pack...

[]

0

[ "PFAM" ]

[ "PF26600" ]

[ "zf-CHCC_shd" ]

[ 141 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Eukaryota" ]

[ 141 ]

1

[]

0

true

Domain

Putative CHCC zinc finger

Znf-CHCC_shd

1

IPR058256

58,256

WLGC domain

WLGC

Domain

664

false

This domain is found in uncharacterised proteins mainly from Oomycetes. It is predicted to fold into a three-stranded antiparallel β-sheet with a small α-helix packed on it and a C-terminal α-helical extension. This domain contains six highly conserved cysteine residues which are predicted to form disulfide bonds. At i...

[]

0

[ "PFAM" ]

[ "PF26605" ]

[ "WLGC" ]

[ 664 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Peronosporomycetes" ]

[ 664 ]

1

[]

0

true

Domain

WLGC domain

WLGC

5

IPR058257

58,257

CorA-like transporter domain

CorA-like_dom

Domain

1,894

false

This entry represents probable membrane transporters mainly from fungi which are distantly related to prokaryotic CorA transporter.

[]

0

[ "PFAM" ]

[ "PF26616" ]

[ "CorA-like" ]

[ 1894 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Opisthokonta" ]

[ 1894 ]

1

[]

0

true

Domain

CorA-like transporter domain

CorA-like_dom

1

IPR058258

58,258

CcmS related domain

CcmS-rel_dom

Domain

294

false

This entry represents a domain found in uncharacterised proteins mainly from fungi. It has a significant similarity to the bacterial chaperone CcmS and it is predicted to adopt similar structure.

[]

0

[ "PFAM" ]

[ "PF26617" ]

[ "CcmS-like" ]

[ 294 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Agaricomycetes", "Bacteria" ]

[ 287, 7 ]

2

[]

0

true

Domain

CcmS related domain

CcmS-rel_dom

5

IPR058259

58,259

Putative Zn2Cys6 domain

Zn2Cys6-like

Domain

23

false

This entry represents a domain that contains a probable binuclear Zn2+ cluster, in which two Zn2+ atoms are bound by six cysteine residues. This domain is similar to PPR1 transcription factor and related Zn2Cys6 DNA-binding domains but elaborated by additional structural elements. The residues probably involved in Zn2+...

[]

0

[ "PFAM" ]

[ "PF26625" ]

[ "Zn2Cys6-like" ]

[ 23 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Dacrymycetaceae" ]

[ 23 ]

1

[]

0

true

Domain

Putative Zn2Cys6 domain

Zn2Cys6-like

1

IPR058260

58,260

Domain of unknown function DUF7954

DUF7954

Domain

44

false

This domain is found at the N-terminal of a range of spirochete proteins. Based on structural similarity to LolA these proteins are likely to be involved in lipid transport.

[]

0

[ "PFAM" ]

[ "PF25843" ]

[ "DUF7954" ]

[ 44 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Spirochaetia" ]

[ 44 ]

1

[]

0

true

Domain

Domain of unknown function DUF7954

DUF7954

3

IPR058261

58,261

Domain of unknown function DUF7955

DUF7955

Domain

43

false

This entry represents a C-terminal domain found in a family of spirochete proteins that are likely involved in lipid transport.

[]

0

[ "PFAM" ]

[ "PF25844" ]

[ "DUF7955" ]

[ 43 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Spirochaetia" ]

[ 43 ]

1

[]

0

true

Domain

Domain of unknown function DUF7955

DUF7955

1

IPR058263

58,263

Repeat of unknown function DUF7957

DUF7957

Repeat

419

false

This domain is found in uncharacterised protein from Halogeometricum borinquense (Hbor_03000) and related prokaryotic proteins. This protein is found next to a toxic gene Hbor_02990 and is likely a immunity protein which is able to prevent self-intoxication [ ]. This domain is predicted to fold into three four-stranded...

[]

0

[ "PFAM" ]

[ "PF25857" ]

[ "DUF7957" ]

[ 419 ]

1

[]

0

[]

0

[ "PUB00160456" ]

[ "39546591" ]

[ "Archaeal type six secretion system mediates contact-dependent antagonism." ]

[ 2024 ]

1

[]

0

null

[ "Bacteria", "Halobacteriales", "Mycena chlorophos", "bioreactor metagenome" ]

[ 363, 53, 1, 2 ]

4

[]

0

true

Repeat

Repeat of unknown function DUF7957

DUF7957

3

IPR058264

58,264

Protein of unknown function DUF7958

DUF7958

Family

341

false

This entry represents uncharacterised protein from Halogeometricum borinquense ( ) and related archaeal proteins. This protein is found next to a toxic gene, Hbor_38900, and is likely an immunity protein which is able to prevent self-intoxication [ ]. This protein is predicted to adopt a complex α/β structure with a un...

[]

0

[ "PFAM" ]

[ "PF25858" ]

[ "DUF7958" ]

[ 341 ]

1

[]

0

[]

0

[ "PUB00160456" ]

[ "39546591" ]

[ "Archaeal type six secretion system mediates contact-dependent antagonism." ]

[ 2024 ]

1

[]

0

null

[ "Halobacteriales" ]

[ 341 ]

1

[]

0

true

Family

Protein of unknown function DUF7958

DUF7958

5

IPR058265

58,265

Domain of unknown function DUF7959

DUF7959

Domain

493

false

This entry represents a presumed ferredoxin-like fold domain found at the C terminus of a range of animal proteins that contain LolA-like domains suggesting these proteins may act as lipoprotein chaperones. The function of this domain is uncertain.

[]

0

[ "PFAM" ]

[ "PF25899" ]

[ "DUF7959" ]

[ 493 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Eumetazoa" ]

[ 493 ]

1

[ "Caenorhabditis elegans" ]

[ 1 ]

1

true

Domain

Domain of unknown function DUF7959

DUF7959

1

IPR058266

58,266

Domain of unknown function DUF7960

DUF7960

Domain

162

false

This entry represents an uncharacterised family found in Methanobacteriota. Structure prediction suggests that this protein binds to a zinc ion. This family includes gene HVO_1405 from Haloferax volcanii.

[]

0

[ "PFAM" ]

[ "PF25901" ]

[ "DUF7960" ]

[ 162 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Halobacteriales" ]

[ 162 ]

1

[]

0

true

Domain

Domain of unknown function DUF7960

DUF7960

5

IPR058267

58,267

Domain of unknown function DUF7961

DUF7961

Domain

181

false

This entry represents an uncharacterised halobacterial protein family. This family is surprisingly composed of half a TIM-barrel fold, related to the domain found in xylose isomerase.

[]

0

[ "PFAM" ]

[ "PF25905" ]

[ "DUF7961" ]

[ 181 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Halobacteriales" ]

[ 181 ]

1

[]

0

true

Domain

Domain of unknown function DUF7961

DUF7961

4

IPR058268

58,268

Domain of unknown function DUF7962

DUF7962

Domain

1,809

false

This entry describes a domain of unknown function predominantly found in bacteria and fungi. It is often associated with which is located at the N-terminal. This domain forms an all α-helical bundle and shows structural similarity to the C-terminal domain of glutathione S-transferase (GST).

[]

0

[ "PFAM" ]

[ "PF25907" ]

[ "DUF7962" ]

[ 1809 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Eukaryota", "Pseudomonadati" ]

[ 1774, 35 ]

2

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)" ]

[ 1 ]

1

true

Domain

Domain of unknown function DUF7962

DUF7962

6

IPR058270

58,270

Domain of unknown function DUF7964

DUF7964

Domain

369

false

This entry represents a family of uncharacterised proteins from halobacteria. These proteins contain a conserved LPXXXP motif towards the N-terminal.

[]

0

[ "PFAM" ]

[ "PF25912" ]

[ "DUF7964" ]

[ 369 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Halobacteriales" ]

[ 369 ]

1

[]

0

true

Domain

Domain of unknown function DUF7964

DUF7964

6

IPR058271

58,271

Domain of unknown function DUF7965

DUF7965

Domain

96

false

This entry represents a small family of uncharacterised halobacterial integral membrane proteins. These proteins have four transmembrane helices, with the N and C-terminal likely being cytoplasmic.

[]

0

[ "PFAM" ]

[ "PF25913" ]

[ "DUF7965" ]

[ 96 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Halobacteriales" ]

[ 96 ]

1

[]

0

true

Domain

Domain of unknown function DUF7965

DUF7965

6

IPR058272

58,272

Protein of unknown function DUF7966

DUF7966

Family

161

false

This entry represents a small family of uncharacterised halobacterial proteins. Structure prediction shows that these proteins form a non-compact fold composed of four α-helices. There is weak evidence from structure prediction that this protein may form a domain-swapped homodimer

[]

0

[ "PFAM" ]

[ "PF25920" ]

[ "DUF7966" ]

[ 161 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Halobacteriales" ]

[ 161 ]

1

[]

0

true

Family

Protein of unknown function DUF7966

DUF7966

8

IPR058273

58,273

Domain of unknown function DUF7967

DUF7967

Domain

733

false

This entry represents a family of uncharacterised halobacterial proteins. The domain adopts a compact domain structure composed of a twisted 5-stranded sheet with a C-terminal α-helix.

[]

0

[ "PFAM" ]

[ "PF25921" ]

[ "DUF7967" ]

[ 733 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Halobacteria" ]

[ 733 ]

1

[]

0

true

Domain

Domain of unknown function DUF7967

DUF7967

5

IPR058274

58,274

Domain of unknown function DUF7968

DUF7968

Domain

241

false

This entry represents a family of uncharacterised halobacterial proteins. The protein assumes a compact domain structure with an N-terminal helix that is packed onto the concave face of a twisted four stranded β sheet.

[]

0

[ "PFAM" ]

[ "PF25922" ]

[ "DUF7968" ]

[ 241 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Halobacteriales" ]

[ 241 ]

1

[]

0

true

Domain

Domain of unknown function DUF7968

DUF7968

4

IPR058275

58,275

Domain of unknown function DUF7969

DUF7969

Domain

267

false

This entry represents a family of uncharacterised halobacterial proteins that adopt a small β sandwich domain structure with a glycine rich C-terminal tail.

[]

0

[ "PFAM" ]

[ "PF25923" ]

[ "DUF7969" ]

[ 267 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Halobacteriales" ]

[ 267 ]

1

[]

0

true

Domain

Domain of unknown function DUF7969

DUF7969

2

IPR058276

58,276

Protein of unknown function DUF7970

DUF7970

Family

715

false

This entry represents a family of uncharacterised proteins found in halobacteria. Proteins in this family are predicted to adopt a series of four α helices that do not form a compact domain. There is weak evidence for a homodimer from structure prediction.

[]

0

[ "PFAM" ]

[ "PF25925" ]

[ "DUF7970" ]

[ 715 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Actinomycetes", "Halobacteriales" ]

[ 6, 709 ]

2

[]

0

true

Family

Protein of unknown function DUF7970

DUF7970

4

IPR058277

58,277

Protein of unknown function DUF7971

DUF7971

Family

247

false

This entry represents a family of uncharacterised proteins found in halobacteria. The proteins are composed of four α helices.

[]

0

[ "PFAM" ]

[ "PF25926" ]

[ "DUF7971" ]

[ 247 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Halobacteriales" ]

[ 247 ]

1

[]

0

true

Family

Protein of unknown function DUF7971

DUF7971

8

IPR058278

58,278

Protein of unknown function DUF7972

DUF7972

Family

1,014

false

This entry represents a family of uncharacterised proteins found in halobacteria. These proteins are about 350-400 amino acids in length. These proteins form a large all α helical fold. These proteins may be integral membrane proteins.

[]

0

[ "PFAM" ]

[ "PF25927" ]

[ "DUF7972" ]

[ 1014 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Methanobacteriota" ]

[ 2, 1012 ]

2

[]

0

true

Family

Protein of unknown function DUF7972

DUF7972

8

IPR058279

58,279

Domain of unknown function DUF7973

DUF7973

Domain

733

false

This entry represents a family of uncharacterised integral membrane proteins found in halobacteria.

[]

0

[ "PFAM" ]

[ "PF25928" ]

[ "DUF7973" ]

[ 733 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Cylicocyclus nassatus", "Halobacteriales", "ecological metagenomes" ]

[ 382, 1, 348, 2 ]

4

[]

0

true

Domain

Domain of unknown function DUF7973

DUF7973

6

IPR058280

58,280

Domain of unknown function DUF7974

DUF7974

Domain

269

false

This entry represents a family of uncharacterised proteins found in halobacteria. These proteins have an immunoglobulin-like domain.

[]

0

[ "PFAM" ]

[ "PF25929" ]

[ "DUF7974" ]

[ 269 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Actinomycetes", "Halobacteriales" ]

[ 11, 258 ]

2

[]

0

true

Domain

Domain of unknown function DUF7974

DUF7974

1

IPR058281

58,281

Domain of unknown function DUF7975

DUF7975

Domain

263

false

This entry represents Propionyl-CoA carboxylase, the protein PccX subunit from Haloferax mediterranei and similar uncharacterised proteins found in halobacteria. PccX is part of the propionyl coenzyme A carboxylase (PCC) complex involved in propionate utilisation and in the production of the poly(3-hydroxybutyrate-co-3...

[]

0

[ "PFAM" ]

[ "PF25930" ]

[ "DUF7975" ]

[ 263 ]

1

[]

0

[]

0

[ "PUB00161612" ]

[ "25398867" ]

[ "Propionyl coenzyme A (propionyl-CoA) carboxylase in Haloferax mediterranei: Indispensability for propionyl-CoA assimilation and impacts on global metabolism." ]

[ 2015 ]

1

[]

0

null

[ "Halobacteriales" ]

[ 263 ]

1

[]

0

true

Domain

Domain of unknown function DUF7975

DUF7975

3