LiteFold/InterPro · Datasets at Hugging Face

IPR058058

58,058

CBU_0592-like

Domain

2,500

false

This entry represents an uncharacterised domain found in CBU_0592 protein from Coxiella burnetii RSA 493 and related proteins. These proteins are about 90 amino acids in length and rich in hydrophobic residues, suggesting a location largely in the membrane. A minority have an additional C-terminal domain related to cyc...

[]

0

[ "NCBIFAM", "PFAM" ]

[ "NF047864", "PF26604" ]

[ "CBU_0592_membra", "CBU_0592" ]

[ 2334, 2497 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Caudoviricetes", "Eukaryota", "unclassified sequences" ]

[ 26, 2425, 11, 16, 22 ]

5

[]

0

true

Domain

CBU_0592-like

4

IPR058059

58,059

PA3496-like

Family

2,970

false

This poorly understood protein family consists of small and highly divergent proteins, about 65 amino acids long. It is widely distributed in Gram-negative bacteria. One member, PA3496 from Pseudomonas aeruginosa, was shown to be upregulated in the presence of inulin or inulin-derived fructooligosaccharide. Moraxella c...

[]

0

[ "NCBIFAM" ]

[ "NF046101" ]

[ "PA3496_fam" ]

[ 2970 ]

1

[]

0

[]

0

[ "PUB00159105", "PUB00159106" ]

[ "24344868", "32153524" ]

[ "Deciphering the genetic basis of Moraxella catarrhalis complement resistance: a critical role for the disulphide bond formation system.", "Full Transcriptomic Response of Pseudomonas aeruginosa to an Inulin-Derived Fructooligosaccharide." ]

[ 2014, 2020 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 2956, 2, 12 ]

3

[]

0

true

Family

PA3496-like

3

IPR058060

58,060

HYC_CC_PP family protein

HYC_CC_PP

Family

2,464

false

This uncharacterised family of proteins, widespread in gram-negative bacteria, is named for three well-conserved motifs, HYC, CC (which may appear twice), and PP.

[]

0

[ "NCBIFAM" ]

[ "NF047658" ]

[ "HYC_CC_PP" ]

[ 2464 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "metagenomes" ]

[ 2435, 29 ]

2

[]

0

true

Family

HYC_CC_PP family protein

HYC_CC_PP

6

IPR058061

58,061

SCO4848-like

Family

2,043

false

This entry represents SCO4848 from Streptomyces coelicolor A3(2) , a 79 amino acid putative membrane protein. It is best known for having the integration site for Streptomyces phage phiBT1 lie within its gene. Homologs of SCO4848 are found broadly within Streptomyces, Saccharomonospora, Arthrobacter, and Nocardioides, ...

[]

0

[ "NCBIFAM", "PFAM" ]

[ "NF046117", "PF26606" ]

[ "SCO4848_fam", "SCO4848" ]

[ 2012, 2043 ]

2

[]

0

[]

0

[ "PUB00105553" ]

[ "12923110" ]

[ "Integration site for Streptomyces phage phiBT1 and development of site-specific integrating vectors." ]

[ 2003 ]

1

[]

0

null

[ "Bacteria", "metagenomes" ]

[ 2037, 6 ]

2

[]

0

true

Family

SCO4848-like

7

IPR058062

58,062

SCO7613, C-terminal domain

SCO7613_C

Domain

1,713

false

This entry describes a conserved region found at the C-terminal of large but variable-length hydrophobic proteins found mostly in members of the Actinomycetes such as Streptomyces, Micromonospora, Actinoplanes, and Nocardioides. The founding member, SCO7613 from Streptomyces coelicolor, is among a limited set of protei...

[]

0

[ "NCBIFAM" ]

[ "NF047321" ]

[ "SCO7613_CTERM" ]

[ 1713 ]

1

[]

0

[]

0

[ "PUB00159414", "PUB00159568" ]

[ "30530707", "34377052" ]

[ "Novel Two-Component System MacRS Is a Pleiotropic Regulator That Controls Multiple Morphogenic Membrane Protein Genes in Streptomyces coelicolor.", "Polyhydroxyalkanoate accumulation in Streptomyces coelicolor affected by SCO7613 gene region." ]

[ 2019, 2021 ]

2

[]

0

null

[ "Bacteria", "metagenomes" ]

[ 1709, 4 ]

2

[]

0

true

Domain

SCO7613, C-terminal domain

SCO7613_C

3

IPR058063

58,063

FFLEELY motif contaning

FFLEE_fam

Family

1,027

false

This uncharacterised family is named for its highly conserved motif, FF[LVF][ED][ED]LY. Members of this family are found mostly in gammaproteobacterial genera such as Acinetobacter, Aeromonas, Alteromonas, and Psychrobacter, but also in betaproteobacteria and in the Leptospira genus of spirochetes.

[]

0

[ "NCBIFAM" ]

[ "NF047641" ]

[ "FFLEE_fam" ]

[ 1027 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "ecological metagenomes" ]

[ 1025, 2 ]

2

[]

0

true

Family

FFLEELY motif contaning

FFLEE_fam

7

IPR058064

58,064

STM2901-like

Family

1,145

false

The founding member of this family of uncharacterised proteins is STM2901, a putative cytoplasmic protein from many but not all forms of SPI-1 (Salmonella Pathogenicity Island 1). Members of this family are found in gamma- and betaproteobacteria.

[]

0

[ "NCBIFAM" ]

[ "NF045926" ]

[ "STM2901_fam" ]

[ 1145 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Erwinia phage EtG", "Pseudomonadati" ]

[ 1, 1144 ]

2

[]

0

true

Family

STM2901-like

9

IPR058065

58,065

LIC_10190-like

Family

594

false

Members of this broadly distributed family average about 600 amino acids in length and are highly hydrophobic. Two of the very few invariant amino acids occur in a DxxxY motif. Some members of this family show sequence similarity to dolichyl-phosphate-mannose-protein mannosyltransferases (see ), suggesting they may be ...

[]

0

[ "NCBIFAM" ]

[ "NF047510" ]

[ "LIC_10190_fam" ]

[ 594 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Methanomicrobia", "ecological metagenomes" ]

[ 587, 4, 3 ]

3

[]

0

true

Family

LIC_10190-like

9

IPR058066

58,066

pXO2-14/BXB0013/GBAA_pXO2_0013, N-terminal domain

pXO2-14_N

Domain

780

false

This entry represents the N-terminal domain in large, membrane-embedded proteins of mobile elements such as the Bacillus subtilis natto plasmid pLS20. They show distant relationships to better-characterised VirB-like conjugal transfer proteins. These proteins also show homology to the family of Mbov_0396-like transmemb...

[]

0

[ "NCBIFAM" ]

[ "NF045890" ]

[ "conj_pls20_p028" ]

[ 780 ]

1

[]

0

[]

0

[ "PUB00159546" ]

[ "16556997" ]

[ "Conjugational transfer kinetics of pLS20 between Bacillus subtilis in liquid medium." ]

[ 2006 ]

1

[]

0

null

[ "Bacteria", "human gut metagenome" ]

[ 779, 1 ]

2

[]

0

true

Domain

pXO2-14/BXB0013/GBAA_pXO2_0013, N-terminal domain

pXO2-14_N

1

IPR058067

58,067

CC_3452-like

Family

388

false

This entry represents a family of uncharacterised proteins found mainly in alphaproteobacteria.

[]

0

[ "NCBIFAM" ]

[ "NF047636" ]

[ "CC_3452_fam" ]

[ 388 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Pseudomonadota", "hydrothermal vent metagenome" ]

[ 384, 4 ]

2

[]

0

true

Family

CC_3452-like

3

IPR058068

58,068

LIC_13387-like

Family

437

false

This entry represents a family of uncharacterised bacterial proteins. It is named for LIC_13387 from Leptospira interrogans, but members are found in wide variety of bacterial species. In Leptospira, LIMLP_17285 was observed to have lower expression in response to hydrogen peroxide stress.

[]

0

[ "NCBIFAM" ]

[ "NF047765" ]

[ "LIC_13387_fam" ]

[ 437 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Dikarya", "ecological metagenomes" ]

[ 417, 13, 7 ]

3

[]

0

true

Family

LIC_13387-like

3

IPR058069

58,069

Threonine/serine transporter ThrP

ThrP

Family

1,054

false

This entry represents Threonine/serine transporter ThrP, a member of the Amino Acid-Polyamine-Organocation (APC) family according to the transporter classification database (TDCB.org). Threonine and serine are substrates. In Escherichia coli K-12, the member protein was previously known as YifK. ThrP is a permease that...

[]

0

[ "NCBIFAM" ]

[ "NF047867" ]

[ "AA_transp_ThrP" ]

[ 1054 ]

1

[]

0

[]

0

[ "PUB00159871" ]

[ "37025642" ]

[ "A study on L-threonine and L-serine uptake in Escherichia coli K-12." ]

[ 2023 ]

1

[]

0

null

[ "Pseudomonadota", "Trichuris trichiura", "human gut metagenome" ]

[ 1052, 1, 1 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Threonine/serine transporter ThrP

ThrP

8

IPR058070

58,070

Morphogenic membrane protein MmpB

MmpB-like

Family

609

false

This entry represents the morphogenic membrane protein MmpB and related proteins from Streptomycetaceae. MmpB expression in S. coelicolor is regulated by a two-component system (TCS) MacRS [ ]. MmpB interacts with the membrane proteins MmpA and MmpC, which are also regulated by MacRS TCS [ ]. MmpA-C proteins are morpho...

[]

0

[ "NCBIFAM", "PFAM" ]

[ "NF047320", "PF26627" ]

[ "morpho_MmpB", "MmpB" ]

[ 604, 609 ]

2

[]

0

[]

0

[ "PUB00159414" ]

[ "30530707" ]

[ "Novel Two-Component System MacRS Is a Pleiotropic Regulator That Controls Multiple Morphogenic Membrane Protein Genes in Streptomyces coelicolor." ]

[ 2019 ]

1

[]

0

null

[ "Actinomycetes" ]

[ 609 ]

1

[]

0

true

Family

Morphogenic membrane protein MmpB

MmpB-like

1

IPR058071

58,071

WalR, receiver domain

WalR_REC

Domain

2,581

false

This entry represents the phosphoacceptor receiver (REC) domain of Transcriptional regulatory protein WalR from Bacillus subtilis (also known as YycF) and similar proteins predominantly found in firmicutes. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phos...

[]

0

[ "CDD" ]

[ "cd17614" ]

[ "REC_OmpR_YycF-like" ]

[ 2581 ]

1

[]

0

[ "1nxo", "1nxp", "1nxs", "1nxt", "1nxv", "1nxw", "1nxx", "2a9o", "2a9p", "2a9r", "2zwm", "3f6p", "6eb7", "6ebb", "6ebr", "8fk2" ]

16

[ "PUB00029263", "PUB00053583", "PUB00105822", "PUB00107112", "PUB00108123", "PUB00127901", "PUB00150104", "PUB00150867", "PUB00160917", "PUB00160918" ]

[ "15090529", "16740923", "22276191", "20226724", "11226872", "17581128", "19574649", "12950927", "15774879", "27610104" ]

[ "Crystal structure of the response regulator 02 receiver domain, the essential YycF two-component system of Streptococcus pneumoniae in both complexed and native states.", "Structural classification of bacterial response regulators: diversity of output domains and domain combinations.", "Purification and activi...

[ 2004, 2006, 2012, 2010, 2001, 2007, 2009, 2003, 2005, 2016 ]

10

[ "IPR001789" ]

[]

1

0

1

[ "Bacteria", "Opisthokonta" ]

[ 2579, 2 ]

2

[]

0

true

Domain

WalR, receiver domain

WalR_REC

9

IPR058072

58,072

LIC_12708-like

LIC12708-like

Family

241

false

This entry represents putative bacterial lipoproteins mainly found in spirochetes. They are named after LIC_12708 from Leptospira interrogans. Some of the members contain a lipoprotein lipid attachment site suggesting they may be associated with the membrane.

[]

0

[ "NCBIFAM" ]

[ "NF047780" ]

[ "LIC12708_fam" ]

[ 241 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Spirochaetia", "bioreactor metagenome" ]

[ 240, 1 ]

2

[]

0

true

Family

LIC_12708-like

LIC12708-like

6

IPR058073

58,073

Silver-binding protein SilE

SilE

Family

291

false

Silver-binding protein SilE is a component of the Sil cation-efflux system that provides resistance to silver. SilE functions as a periplasmic molecular sponge for silver ions, capable of binding up to 38 Ag+ ions. It shares approximately 48% sequence identity with the periplasmic copper-binding protein PcoE, which is ...

[]

0

[ "NCBIFAM" ]

[ "NF047789" ]

[ "AgBindSilE" ]

[ 291 ]

1

[]

0

[]

0

[ "PUB00099025", "PUB00159140", "PUB00159141" ]

[ "9930866", "27085056", "34396382" ]

[ "Molecular basis for resistance to silver cations in Salmonella.", "SilE is an intrinsically disordered periplasmic \"molecular sponge\" involved in bacterial silver resistance.", "NMR reveals the interplay between SilE and SilB model peptides in the context of silver resistance." ]

[ 1999, 2016, 2021 ]

3

[]

0

null

[ "Bacteria" ]

[ 291 ]

1

[]

0

true

Family

Silver-binding protein SilE

SilE

9

IPR058074

58,074

Bacteriocin-like conserved region

Bacteriocin-like

Conserved_site

1,576

false

The sequence region that defines this family is found predominantly in the genus Chryseobacterium, consistently located at the N terminus. It terminates with a Gly-Gly (or occasionally Gly-Ala) motif, beyond which the sequences, while typically rich in cysteine, exhibit considerable diversity. This pattern is highly ch...

[]

0

[ "NCBIFAM" ]

[ "NF047798" ]

[ "leader_Chryseo" ]

[ 1576 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria" ]

[ 1576 ]

1

[]

0

true

Conserved_site

Bacteriocin-like conserved region

Bacteriocin-like

8

IPR058075

58,075

Chitoporin

Family

1,042

false

This entry represents enterobacterial chitoporin and related proteins from gammaproteobacteria. Chitoporin is an outer membrane protein required to import chitin-derived oligosaccharides [ ].

[]

0

[ "NCBIFAM" ]

[ "NF047822" ]

[ "ChporEntbacChiP" ]

[ 1042 ]

1

[]

0

[ "7vtz", "7vu0", "7vu1", "7vu2", "7vu3" ]

5

[ "PUB00159862", "PUB00159869" ]

[ "19638370", "19682266" ]

[ "Caught at its own game: regulatory small RNA inactivated by an inducible transcript mimicking its target.", "Switching off small RNA regulation with trap-mRNA." ]

[ 2009, 2009 ]

2

[ "IPR005318" ]

[]

1

0

1

[ "Gammaproteobacteria", "Opisthokonta" ]

[ 1040, 2 ]

2

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Chitoporin

1

IPR058076

58,076

NADH oxidase

NOXase

Family

954

false

This protein family includes NADH oxidase from Streptococcus pneumoniae (NOXase) and similar sequences mainly found in firmicutes. NOXase catalyses the four-electron reduction of molecular oxygen to water and may be involved in mediating bacterial adhesion to host cells [ , ]. It plays a role in redox balance maintenan...

[ "GO:0016491" ]

[ "oxidoreductase activity" ]

[ "molecular_function" ]

1

[ "NCBIFAM" ]

[ "NF046103" ]

[ "NOXase_Strep" ]

[ 954 ]

1

[ "EC" ]

[ "1.6.3.4" ]

[ "EC:1.6.3.4" ]

1

[ "2bc0", "2bc1", "2bcp" ]

3

[ "PUB00159563", "PUB00159564", "PUB00159565", "PUB00160955", "PUB00160956" ]

[ "23577197", "10594826", "11158360", "26506002", "36928033" ]

[ "NADH oxidase functions as an adhesin in Streptococcus pneumoniae and elicits a protective immune response in mice.", "The NADH oxidase of Streptococcus pneumoniae: its involvement in competence and virulence.", "Characterization of the Streptococcus pneumoniae NADH oxidase that is required for infection.", "...

[ 2013, 1999, 2001, 2015, 2023 ]

5

[ "IPR050260" ]

[]

1

0

1

[ "Bacteria" ]

[ 954 ]

1

[]

0

true

Family

NADH oxidase

NOXase

6

IPR058077

58,077

Ag473-like

Family

45

false

Members of this surface-exposed meningococcal lipoprotein family, called Ag473, have variable numbers of the sequence KEAVTEA. Most members contain a lipoprotein lipid attachment site suggesting may be associated with the membrane.

[]

0

[ "NCBIFAM" ]

[ "NF047840" ]

[ "lipo_Ag473" ]

[ 45 ]

1

[]

0

[]

0

[ "PUB00159739", "PUB00159740", "PUB00159741" ]

[ "22844415", "18491322", "20937316" ]

[ "The immunomodulatory activity of meningococcal lipoprotein Ag473 depends on the conformation made up of the lipid and protein moieties.", "Immunoproteomic identification of the hypothetical protein NMB1468 as a novel lipoprotein ubiquitous in Neisseria meningitidis with vaccine potential.", "Biochemical charac...

[ 2012, 2008, 2010 ]

3

[]

0

null

[ "Neisseriaceae" ]

[ 45 ]

1

[]

0

true

Family

Ag473-like

2

IPR058078

58,078

Cj0814 flagellar-dependent secreted protein

Cj0814-like

Family

1,076

false

Members of this family, restricted to the genus Campylobacter, appear not to be flagellar proteins, but depend on flagellar expression in order to be secreted and be found in culture supernatant.

[]

0

[ "NCBIFAM", "PFAM" ]

[ "NF046095", "PF28266" ]

[ "flg_dep_Cj0814", "Cj0814" ]

[ 614, 1066 ]

2

[]

0

[]

0

[ "PUB00159632" ]

[ "27865792" ]

[ "A quantitative proteomic screen of the Campylobacter jejuni flagellar-dependent secretome." ]

[ 2017 ]

1

[]

0

null

[ "Campylobacterales", "Myoviridae sp. ctTBm11" ]

[ 1072, 4 ]

2

[]

0

true

Family

Cj0814 flagellar-dependent secreted protein

Cj0814-like

1

IPR058079

58,079

LIC_12936-like

Family

127

false

Members of this family are named after LIC_12936 from Leptospira interrogans, and found in all three clades of Leptospira (Pathogenic, Intermediate, and Saprophytic). Members have a conserved signal peptide region. The function is unknown.

[]

0

[ "NCBIFAM", "PFAM" ]

[ "NF047758", "PF28267" ]

[ "LIC12936_fam", "LIC_12936" ]

[ 120, 127 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Leptospira" ]

[ 127 ]

1

[]

0

true

Family

LIC_12936-like

4

IPR058080

58,080

LBF_1011-like

Family

64

false

This family is named after protein LBF_1011 from Leptospira biflexa, a saprophytic (non-pathogenic) species of Leptospira.

[]

0

[ "NCBIFAM", "PFAM" ]

[ "NF047757", "PF28269" ]

[ "LBF_1011_fam", "LBF_1011" ]

[ 33, 64 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Leptospira" ]

[ 64 ]

1

[]

0

true

Family

LBF_1011-like

1

IPR058081

58,081

LBF_2127

Family

67

false

Members of this family of putative lipoproteins occur in more than half the known species of Leptospira and Leptonema. The function is unknown. The founding member is LBF_2127.

[]

0

[ "NCBIFAM", "PFAM" ]

[ "NF047770", "PF28270" ]

[ "LBF_2127_lipo", "LBF_2127" ]

[ 65, 67 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Pseudomonadati" ]

[ 67 ]

1

[]

0

true

Family

LBF_2127

6

IPR058084

58,084

Slr1658-like

Family

566

false

This entry represents Slr1658 protein and homologues. It has been reported that Slr1658 had extensive effects on the expression of genes encoding regulatory proteins, proteins involved in the remodelling and degradation of the photosynthetic apparatus and proteins modulating electron transport in Cyanobacteria. Slr1658...

[]

0

[ "NCBIFAM" ]

[ "NF047703" ]

[ "slr1658_superfam" ]

[ 566 ]

1

[]

0

[]

0

[ "PUB00159603" ]

[ "29161470" ]

[ "Resequencing of a mutant bearing an iron starvation recovery phenotype defines Slr1658 as a new player in the regulatory network of a model cyanobacterium." ]

[ 2018 ]

1

[]

0

null

[ "Bacteria" ]

[ 566 ]

1

[]

0

true

Family

Slr1658-like

1

IPR058085

58,085

PP_RS20740-like

Family

60

false

This entry represents a subset of uncharacterised bacterial proteins related to PP_RS20740 from Pseudomonas putida. A missense mutation (V338F) in this protein improved tolerance to furfural, a metabolite of pentose degradation [ ]. The function is unknown.

[]

0

[ "NCBIFAM", "PFAM" ]

[ "NF047698", "PF28273" ]

[ "PP_RS20740_fam", "PP_RS20740" ]

[ 51, 60 ]

2

[]

0

[]

0

[ "PUB00159602" ]

[ "36338095" ]

[ "Unraveling the mechanism of furfural tolerance in engineered Pseudomonas putida by genomics." ]

[ 2022 ]

1

[]

0

null

[ "Bacteria", "metagenomes" ]

[ 57, 3 ]

2

[]

0

true

Family

PP_RS20740-like

8

IPR058086

58,086

Immunodominant staphylococcal antigen B

IsaB

Family

397

false

This entry represents IsaB (immunodominant staphylococcal antigen B, or immunodominant surface antigen B) from Staphylococcus aureus. IsaB is a virulence factor that impedes autophagy by host defence systems. It is unrelated to IsaA, an apparent soluble lytic transglycosylase [ ]. Additional members of this family are ...

[]

0

[ "NCBIFAM", "PFAM" ]

[ "NF047686", "PF27443" ]

[ "IsaB_fam", "IsaB" ]

[ 394, 371 ]

2

[]

0

[]

0

[ "PUB00159842", "PUB00159843", "PUB00162108" ]

[ "26134948", "23009799", "15870358" ]

[ "IsaB Inhibits Autophagic Flux to Promote Host Transmission of Methicillin-Resistant Staphylococcus aureus.", "Regulation of Staphylococcus aureus immunodominant antigen B (IsaB).", "Differential gene expression profiling of Staphylococcus aureus cultivated under biofilm and planktonic conditions." ]

[ 2015, 2013, 2005 ]

3

[]

0

null

[ "Bacilli", "human gut metagenome" ]

[ 395, 2 ]

2

[]

0

true

Family

Immunodominant staphylococcal antigen B

IsaB

5

IPR058087

58,087

XAC2610 domain

XAC2610_dom

Domain

2,440

false

This entry represents a central domain in Xanthomonas Type IV Secretion System related protein [ ] and related proteins. This domain is formed by two β-sheets. This group of proteins includes XAC2610 , an immunity protein that neutralises the peptidoglycan hydrolase activity of the effector protein X-Tfe (XAC2609) and ...

[]

0

[ "NCBIFAM" ]

[ "NF047539" ]

[ "XAC2610_fam" ]

[ 2440 ]

1

[]

0

[ "4qtq" ]

1

[ "PUB00145392", "PUB00163354" ]

[ "25743609", "38332152" ]

[ "Bacterial killing via a type IV secretion system.", "Xanthomonas immunity proteins protect against the cis-toxic effects of their cognate T4SS effectors." ]

[ 2015, 2024 ]

2

[]

0

null

[ "Bacteria", "Knufia peltigerae", "metagenomes" ]

[ 2428, 1, 11 ]

3

[]

0

true

Domain

XAC2610 domain

XAC2610_dom

8

IPR058088

58,088

Peptidoglycan hydrolase PcsB

PcsB

Family

392

false

This entry represents Peptidoglycan hydrolase PcsB from Streptococcus pneumoniae and similar proteins from lactobacillales. PcsB is required for the maintenance of normal growth and cellular morphology [ , , ] and is involved in the splitting of the septum during cell division [ ]. This protein is organised into three ...

[]

0

[ "NCBIFAM" ]

[ "NF046104" ]

[ "PptglHdxlasePcsB" ]

[ 392 ]

1

[ "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC"...

[ "3.2.1.-", "PWY-1921", "PWY-5821", "PWY-5976", "PWY-6527", "PWY-6717", "PWY-6735", "PWY-6737", "PWY-6749", "PWY-6784", "PWY-6821", "PWY-6848", "PWY-6855", "PWY-6906", "PWY-6972", "PWY-7056", "PWY-7057", "PWY-7074", "PWY-7091", "PWY-7133", "PWY-7134", "PWY-7256", "PWY-7445...

[ "EC:3.2.1.-", "METACYC:PWY-1921", "METACYC:PWY-5821", "METACYC:PWY-5976", "METACYC:PWY-6527", "METACYC:PWY-6717", "METACYC:PWY-6735", "METACYC:PWY-6737", "METACYC:PWY-6749", "METACYC:PWY-6784", "METACYC:PWY-6821", "METACYC:PWY-6848", "METACYC:PWY-6855", "METACYC:PWY-6906", "METACYC:PWY-6...

31

[ "4cgk" ]

1

[ "PUB00153385", "PUB00153386", "PUB00153387", "PUB00153388" ]

[ "14651645", "15306019", "19270090", "24804636" ]

[ "Constitutive expression of PcsB suppresses the requirement for the essential VicR (YycF) response regulator in Streptococcus pneumoniae R6.", "Defective cell wall synthesis in Streptococcus pneumoniae R6 depleted for the essential PcsB putative murein hydrolase or the VicR (YycF) response regulator.", "Influen...

[ 2003, 2004, 2009, 2014 ]

4

[ "IPR009148" ]

[]

1

0

1

[ "Bacteria" ]

[ 392 ]

1

[]

0

true

Family

Peptidoglycan hydrolase PcsB

PcsB

2

IPR058089

58,089

EgtUBC, C-terminal periplasmic solute-binding domain

EgtUBC_SBD

Domain

2,208

false

This entry represents the C-terminal periplasmic solute-binding domain (SBD) of Probable ergothioneine transporter EgtUBC from Staphylococcus aureus and similar proteins predominantly found in firmicutes. EgtUBC is part of an ABC transporter complex EgtU required for the uptake of ergothioneine (EGT), a natural low-mol...

[]

0

[ "CDD" ]

[ "cd13610" ]

[ "PBP2_ChoS" ]

[ 2208 ]

1

[]

0

[ "4z7e", "7txk", "7txl" ]

3

[ "PUB00003610", "PUB00056198", "PUB00061609", "PUB00080630", "PUB00113453", "PUB00130325", "PUB00130326", "PUB00160959" ]

[ "8336670", "11741199", "16645306", "9931266", "10733987", "21658392", "17875413", "36481738" ]

[ "Structural, functional, and evolutionary relationships among extracellular solute-binding receptors of bacteria.", "The Venus flytrap of periplasmic binding proteins: an ancient protein module present in multiple drug receptors.", "Biochemical and structural analysis of the Bacillus subtilis ABC transporter Op...

[ 1993, 1999, 2005, 1999, 2000, 2011, 2007, 2022 ]

8

[ "IPR007210" ]

[]

1

0

1

[ "Bacteria", "Eukaryota", "human gut metagenome" ]

[ 2205, 2, 1 ]

3

[]

0

true

Domain

EgtUBC, C-terminal periplasmic solute-binding domain

EgtUBC_SBD

5

IPR058090

58,090

50S ribosomal protein bL37, actinomycetota type

bL37_actino

Family

578

false

This entry represents the homologues of bL37 ribosomal protein. bL37 is a small, highly basic protein found in the ribosomes of certain bacteria, notably mycobacteria such as Mycolicibacterium smegmatis and Mycobacterium tuberculosis. It consists of 24 amino acids and has a theoretical molecular weight of about 2.84 kD...

[]

0

[ "NCBIFAM", "PFAM" ]

[ "NF047428", "PF26427" ]

[ "ribo_Myco_bL37", "HR_L37" ]

[ 568, 578 ]

2

[]

0

[ "5o60", "5o61", "5xym", "5zeb", "5zep", "5zet", "6dzi", "6dzp", "7kgb", "7msc", "7msh", "7msm", "7msz", "7mt2", "7mt3", "7mt7", "7s0s", "7sfr", "7xam", "7y41", "8crx", "8cvm", "8fr8", "8kab", "8v9j", "8v9k", "8v9l", "8vio", "8vk0", "8vk7", "8vki", "8vkw"...

45

[ "PUB00105396", "PUB00113200", "PUB00159590", "PUB00160962", "PUB00160963", "PUB00160964", "PUB00161273" ]

[ "31402174", "28683309", "30206241", "35355474", "35064151", "39122144", "36827973" ]

[ "Large-Scale Analyses of Human Microbiomes Reveal Thousands of Small, Novel Genes.", "The Complete Structure of the Mycobacterium smegmatis 70S Ribosome.", "Structures of Mycobacterium smegmatis 70S ribosomes in complex with HPF, tmRNA, and P-tRNA.", "[Knockout of ribosomal genes bS22 and bL37 i...

[ 2019, 2017, 2018, 2022, 2022, 2024, 2023 ]

7

[]

0

null

[ "Actinomycetota" ]

[ 578 ]

1

[]

0

true

Family

50S ribosomal protein bL37, actinomycetota type

bL37_actino

8

IPR058091

58,091

FcpA

Family

118

false

This entry represents FcpA (flagellar-coiling protein A, , LEPBI_I0267) from Leptospira biflexa and similar sequences from Leptospira, Leptonema and Turneriella. It is part of the filament sheath of the spirochete periplasmic flagellum [ , , , ].

[]

0

[ "NCBIFAM" ]

[ "NF047448" ]

[ "flagella_FcpA" ]

[ 118 ]

1

[]

0

[ "6nqw", "6nqx", "6nqy", "6pwb" ]

4

[ "PUB00159333", "PUB00159334", "PUB00159335", "PUB00159395" ]

[ "27113476", "29634754", "28291747", "29868490" ]

[ "A novel flagellar sheath protein, FcpA, determines filament coiling, translational motility and virulence for the Leptospira spirochete.", "Leptospiral flagellar sheath protein FcpA interacts with FlaA2 and FlaB1 in Leptospira biflexa.", "Crystallization of FcpA from Leptospira, a novel flagellar protein that ...

[ 2016, 2018, 2017, 2018 ]

4

[ "IPR060703" ]

[]

1

0

1

[ "Leptospiraceae" ]

[ 118 ]

1

[]

0

true

Family

FcpA

7

IPR058092

58,092

WWWY-motif domain

WWWY

Domain

19

false

This extremely hydrophobic domain is found in Clostridia and related Gram-positive species, either as the C-terminal portion of a protein with an N-terminal predicted helix-turn-helix (HTH) DNA-binding domain or standalone. This domain includes a highly unusual motif within a strongly hydrophobic stretch, WxxxWxxWxxY, ...

[]

0

[ "NCBIFAM" ]

[ "NF047451" ]

[ "WxxxWxxW_dom" ]

[ 19 ]

1

[]

0

[]

0

[ "PUB00105396" ]

[ "31402174" ]

[ "Large-Scale Analyses of Human Microbiomes Reveal Thousands of Small, Novel Genes." ]

[ 2019 ]

1

[]

0

null

[ "Bacillati" ]

[ 19 ]

1

[]

0

true

Domain

WWWY-motif domain

WWWY

9

IPR058093

58,093

LA_2272-like repeat

LA_2272-like

Repeat

1,211

false

This entry represents a 15-amino acid repeat. Numbers of repeats in proteins vary. Notable surface-exposed proteins with this repeat domain include lipoproteins LA_2272 (Q8F3X7) and LA_2273 (Q8F3X6) from Leptospira interrogans and VC2662 (Q9KNR9) from Vibrio cholerae.

[]

0

[ "NCBIFAM" ]

[ "NF047436" ]

[ "LA_2272_repeat" ]

[ 1211 ]

1

[]

0

[]

0

[ "PUB00159139", "PUB00159320" ]

[ "38206049", "28352257" ]

[ "Outer membrane vesicles and the outer membrane protein OmpU govern Vibrio cholerae biofilm matrix assembly.", "A Novel Pan-Genome Reverse Vaccinology Approach Employing a Negative-Selection Strategy for Screening Surface-Exposed Antigens against leptospirosis." ]

[ 2024, 2017 ]

2

[]

0

null

[ "Bacteria", "Hirondellea gigas", "unclassified sequences" ]

[ 1202, 1, 8 ]

3

[]

0

true

Repeat

LA_2272-like repeat

LA_2272-like

7

IPR058094

58,094

OmpL47-like, Ig-like domain

Ig-like_OmpL47-like

Domain

3,858

false

This entry represents an Ig-like domain in Leptospira surface-exposed protein OmpL47 [ ] and related proteins, usually annotated as Ig-like domain-containing proteins or as carbohydrate-active enzymes. This domain can be found as tandem copies from 3 to 12 repetitions.

[]

0

[ "NCBIFAM" ]

[ "NF047446" ]

[ "barrel_OmpL47" ]

[ 3858 ]

1

[]

0

[]

0

[ "PUB00159260" ]

[ "19562037" ]

[ "A comprehensive approach to identification of surface-exposed, outer membrane-spanning proteins of Leptospira interrogans." ]

[ 2009 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "ecological metagenomes" ]

[ 37, 3759, 11, 51 ]

4

[]

0

true

Domain

OmpL47-like, Ig-like domain

Ig-like_OmpL47-like

7

IPR058095

58,095

Psb35-like

Family

187

false

This undescribed putative photosystem II protein is related to Psb35 and is restricted to species that have photosystem II, primarily derived from cyanobacteria [ ].

[]

0

[ "NCBIFAM", "PFAM" ]

[ "NF047380", "PF26637" ]

[ "photo_II_xxx", "DUF8210" ]

[ 185, 187 ]

2

[]

0

[]

0

[ "PUB00159047" ]

[ "33258963" ]

[ "Psb35 Protein Stabilizes the CP47 Assembly Module and Associated High-Light Inducible Proteins during the Biogenesis of Photosystem II in the Cyanobacterium Synechocystis sp. PCC6803." ]

[ 2021 ]

1

[]

0

null

[ "Cyanobacteriota" ]

[ 187 ]

1

[]

0

true

Family

Psb35-like

1

IPR058096

58,096

Sensor histidine protein kinase/phosphatase WalK, streptococcus

WalK_streptococcus

Family

445

false

This protein family includes Sensor histidine protein kinase/phosphatase WalK from Streptococcus pneumoniae, the histidine kinase SMU_1516 from Streptococcus mutans (CovS, ) and similar proteins mainly found in Streptococcus. WalK functions as a sensor protein kinase which is autophosphorylated at a histidine residue a...

[ "GO:0007165" ]

[ "signal transduction" ]

[ "biological_process" ]

1

[ "NCBIFAM" ]

[ "NF033093" ]

[ "HK_VicK" ]

[ 445 ]

1

[]

0

[ "4i5s" ]

1

[ "PUB00153881", "PUB00154837", "PUB00154838", "PUB00154839" ]

[ "23468592", "20190050", "23013245", "27902439" ]

[ "Mechanistic insights revealed by the crystal structure of a histidine kinase with signal transducer and sensor domains.", "Kinetic characterization of the WalRKSpn (VicRK) two-component system of Streptococcus pneumoniae: dependence of WalKSpn (VicK) phosphatase activity on its PAS domain.", "Involvement of Wa...

[ 2013, 2010, 2012, 2017 ]

4

[ "IPR050351" ]

[]

1

0

1

[ "Bacteria" ]

[ 445 ]

1

[]

0

true

Family

Sensor histidine protein kinase/phosphatase WalK, streptococcus

WalK_streptococcus

6

IPR058098

58,098

BRANT-like

Family

121

false

This entry represents putative uncharacterised bacterial proteins mainly from genera Bradyrhizobium, Rhodopseudomonas, Afipia, Nitrobacter, and Tardiphaga (BRANT). It has an N-terminal probable signal-anchor domain and a His-rich C-terminal region.

[]

0

[ "NCBIFAM", "PFAM" ]

[ "NF047414", "PF28279" ]

[ "BRANT_His_rich", "BRANT" ]

[ 107, 121 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Pseudomonadati" ]

[ 121 ]

1

[]

0

true

Family

BRANT-like

7

IPR058099

58,099

XAC0095-like domain

T3SS_XAC0095_dom

Domain

511

false

This entry represents a domain found standalone in XAC0095 from the plant pathogen Xanthomonas axonopodis pv. citri. XAC0095 was shown to interact with HrpG, a response regulator transcription factor responsible for type III secretion system (T3SS) hrp gene expression [ ]. The interaction between XAC0095 and HrpG could...

[]

0

[ "NCBIFAM", "PFAM" ]

[ "NF047335", "PF26642" ]

[ "T3SS_XAC0095", "XAC0095_dom" ]

[ 505, 443 ]

2

[]

0

[]

0

[ "PUB00159291" ]

[ "15342589" ]

[ "New protein-protein interactions identified for the regulatory and structural components and substrates of the type III Secretion system of the phytopathogen Xanthomonas axonopodis Pathovar citri." ]

[ 2004 ]

1

[]

0

null

[ "Pseudomonadota" ]

[ 511 ]

1

[]

0

true

Domain

XAC0095-like domain

T3SS_XAC0095_dom

1

IPR058100

58,100

Secretion system apparatus protein SsaO

SsaO

Family

433

false

This entry represents the homologues of Salmonella pathogenicity island 2 protein SsaO which is a member of a type III secretion system involved in the survival and replication of Salmonella in a host cell [ ].

[]

0

[ "NCBIFAM", "PFAM" ]

[ "NF011879", "PF28280" ]

[ "PRK15352.1", "SsaO" ]

[ 402, 433 ]

2

[]

0

[]

0

[ "PUB00012980" ]

[ "9140973" ]

[ "Functional analysis of ssaJ and the ssaK/U operon, 13 genes encoding components of the type III secretion apparatus of Salmonella Pathogenicity Island 2." ]

[ 1997 ]

1

[]

0

null

[ "Bracon brevicornis", "Pseudomonadota" ]

[ 1, 432 ]

2

[]

0

true

Family

Secretion system apparatus protein SsaO

SsaO

7

IPR058101

58,101

Salmonella pathogenicity island 2 protein C

SipC

Family

466

false

This entry represents the Salmonella pathogenicity island 2 protein C (spiC) and related proteins. SipC is a virulence protein that plays a central role in mammalian macrophage infection, by inhibiting phagosome-lysosome fusion and cellular trafficking, including trafficking of organelles that are devoid of Salmonella ...

[]

0

[ "NCBIFAM" ]

[ "NF011895" ]

[ "PRK15368.1" ]

[ 466 ]

1

[]

0

[]

0

[ "PUB00085104", "PUB00160967" ]

[ "18248436", "10406797" ]

[ "Identification of Salmonella SPI-2 secretion system components required for SpvB-mediated cytotoxicity in macrophages and virulence in mice.", "A Salmonella virulence protein that inhibits cellular trafficking." ]

[ 2008, 1999 ]

2

[]

0

null

[ "Enterobacterales" ]

[ 466 ]

1

[]

0

true

Family

Salmonella pathogenicity island 2 protein C

SipC

6

IPR058102

58,102

Transcriptional regulator peptide PatS

PatS

Family

2

false

This entry represents Transcriptional regulator peptide PatS. PatS occurs in a subset of HetR-containing, heterocyst-forming species [ , , , ]. PatS inhibits heterocyst differentiation; a peptide corresponding to the last 5-6 amino acids blocks heterocyst formation when added exogenously in culture. It controls heteroc...

[]

0

[ "NCBIFAM", "PFAM" ]

[ "NF047415", "PF28281" ]

[ "heterocyst_PatS", "PatS" ]

[ 2, 2 ]

2

[]

0

[]

0

[ "PUB00044663", "PUB00091369", "PUB00159049", "PUB00159053", "PUB00159054", "PUB00159055", "PUB00160974", "PUB00160975" ]

[ "15051891", "26576507", "32762845", "33291589", "29885033", "28859320", "11274121", "9794762" ]

[ "HetR homodimer is a DNA-binding protein required for heterocyst differentiation, and the DNA-binding activity is inhibited by PatS.", "Structural insights into HetR-PatS interaction involved in cyanobacterial pattern formation.", "HetL, HetR and PatS form a reaction-diffusion system to control pattern formatio...

[ 2004, 2015, 2020, 2020, 2018, 2017, 2001, 1998 ]

8

[]

0

null

[ "Nostoc" ]

[ 2 ]

1

[]

0

true

Family

Transcriptional regulator peptide PatS

PatS

5

IPR058103

58,103

SPI-1 type 3 secretion system stator protein

SCTL1

Family

394

false

This entry represents the SPI-1 type 3 secretion system stator protein (SCTL1) from Salmonella typhimurium, also known as Oxygen-regulated invasion protein OrgB, and related proteins. SCTL1 is found in the Salmonella pathogenicity island 1 (SPI-1), a component of the SPI-1 type III secretion system (T3SS). It is homolo...

[]

0

[ "NCBIFAM" ]

[ "NF011850" ]

[ "PRK15322.1" ]

[ 394 ]

1

[]

0

[]

0

[ "PUB00020770", "PUB00104981" ]

[ "10816487", "27686865" ]

[ "Transcriptional organization and function of invasion genes within Salmonella enterica serovar Typhimurium pathogenicity island 1, including the prgH, prgI, prgJ, prgK, orgA, orgB, and orgC genes.", "The Architecture of the Cytoplasmic Region of Type III Secretion Systems." ]

[ 2000, 2016 ]

2

[]

0

null

[ "Pseudomonadota" ]

[ 394 ]

1

[]

0

true

Family

SPI-1 type 3 secretion system stator protein

SCTL1

5

IPR058104

58,104

Type III secretion system chaperone SseA

SseA

Family

404

false

This entry represents the type III secretion system chaperone SseA and related proteins. SseA functions as a type III secretion system (T3SS) chaperone, which is required for SseB and SseD accumulation and secretion [ , ]. It may have a direct role in secretion of SseB and SseD, or may facilitate their correct folding,...

[]

0

[ "NCBIFAM", "PFAM" ]

[ "NF011892", "PF28282" ]

[ "PRK15365.1", "SseA" ]

[ 389, 404 ]

2

[]

0

[]

0

[ "PUB00013032", "PUB00160968", "PUB00160969" ]

[ "12724372", "12603739", "12787732" ]

[ "SseA is a chaperone for the SseB and SseD translocon components of the Salmonella pathogenicity-island-2-encoded type III secretion system.", "SseA acts as the chaperone for the SseB component of the Salmonella Pathogenicity Island 2 translocon.", "SseA is required for translocation of Salmonella pathogenicity...

[ 2003, 2003, 2003 ]

3

[]

0

null

[ "Enterobacterales" ]

[ 404 ]

1

[]

0

true

Family

Type III secretion system chaperone SseA

SseA

3

IPR058105

58,105

Secretion system apparatus protein SsaP

SsaP

Family

411

false

This entry represents the Secretion system apparatus protein SsaP and related proteins. SsaP is a component of the type III secretion system from Salmonella pathogenicity island 2 (SPI2), involved in the survival and replication of Salmonella in a host cell [ ]. SsaP along with ssaL and ssaM do not have significant sim...

[]

0

[ "NCBIFAM", "PFAM" ]

[ "NF011878", "PF28283" ]

[ "PRK15351.1", "SsaP" ]

[ 389, 411 ]

2

[]

0

[]

0

[ "PUB00012980" ]

[ "9140973" ]

[ "Functional analysis of ssaJ and the ssaK/U operon, 13 genes encoding components of the type III secretion apparatus of Salmonella Pathogenicity Island 2." ]

[ 1997 ]

1

[]

0

null

[ "Enterobacterales" ]

[ 411 ]

1

[]

0

true

Family

Secretion system apparatus protein SsaP

SsaP

4

IPR058106

58,106

Slr1339

Family

239

false

This entry represents Slr1339 and related proteins, strictly found in cyanobacteria. Slr1339 is one of several genes (along with sll1734, ssr3402, and ssr1853) found to be significantly induced after a 3-day salt stress in Synechocystis. Knockout mutants of these genes, including slr1339, were notably salt-sensitive, i...

[]

0

[ "NCBIFAM", "PFAM" ]

[ "NF047397", "PF26643" ]

[ "slr1339_fam", "Slr1339" ]

[ 231, 239 ]

2

[]

0

[]

0

[ "PUB00159048" ]

[ "24643737" ]

[ "Metabolomic analysis of the salt-sensitive mutants reveals changes in amino acid and fatty acid composition important to long-term salt stress in Synechocystis sp. PCC 6803." ]

[ 2014 ]

1

[]

0

null

[ "Cyanophyceae", "Eukaryota" ]

[ 231, 8 ]

2

[]

0

true

Family

Slr1339

7

IPR058108

58,108

CptlN-like

CptIN-like

Family

215

false

This entry represents CptN-like toxin component of a type III toxin-antitoxin (TA) system, which consists of a ribonuclease (RNase) toxin that processes its structured and specific cognate RNA antitoxin, which in turn then directly inhibits the toxin. TA systems have been associated with many important phenotypes, like...

[]

0

[ "NCBIFAM", "CDD" ]

[ "NF047359", "cd17492" ]

[ "CptIN", "toxin_CptN" ]

[ 174, 214 ]

2

[]

0

[ "4rmo" ]

1

[ "PUB00138864", "PUB00138865", "PUB00138866", "PUB00138867" ]

[ "26350213", "22434880", "27690100", "25808661" ]

[ "Co-evolution of quaternary organization and novel RNA tertiary interactions revealed in the crystal structure of a bacterial protein-RNA toxin-antitoxin system.", "Identification and classification of bacterial Type III toxin-antitoxin systems encoded in chromosomal and plasmid genomes.", "Structure, Evolution...

[ 2015, 2012, 2016, 2015 ]

4

[]

0

null

[ "Bacteria", "Methanosarcinaceae", "unclassified Caudoviricetes" ]

[ 205, 5, 5 ]

3

[]

0

true

Family

CptlN-like

CptIN-like

4

IPR058109

58,109

FlcA, C-terminal

FlcA_C

Domain

143

false

This entry represents the C-terminal domain in FlcA. This domain contains TPR repeats. In spirochetes, flagella are located within the periplasm. FlcA is one of several structural proteins involved in the formation of the flagellar collar. The conserved N-terminal domain of about 40 amino acids and the C-terminal regio...

[]

0

[ "NCBIFAM" ]

[ "NF047371" ]

[ "FlcA_CTERM" ]

[ 143 ]

1

[]

0

[]

0

[ "PUB00159294" ]

[ "31743518" ]

[ "BB0326 is responsible for the formation of periplasmic flagellar collar and assembly of the stator complex in Borrelia burgdorferi." ]

[ 2020 ]

1

[]

0

null

[ "Bacteria", "Menopon gallinae" ]

[ 142, 1 ]

2

[]

0

true

Domain

FlcA, C-terminal

FlcA_C

4

IPR058111

58,111

RcgR-like

Family

197

false

RcgA (Rhizobial Conjugative Gene A), from a Rhizobium favelukesii plasmid, plays an essential role in a quorum-sensing-dependent conjugative transfer system. It is thought to be a transporter that allows uptake of a quorum-signalling lactone. Its partner protein, RgcR, with an α/β hydrolase domain, inhibits the transfe...

[]

0

[ "NCBIFAM" ]

[ "NF047337" ]

[ "hydrolase_RcgR" ]

[ 197 ]

1

[]

0

[]

0

[ "PUB00159108" ]

[ "36073816" ]

[ "RcgA and RcgR, Two Novel Proteins Involved in the Conjugative Transfer of Rhizobial Plasmids." ]

[ 2022 ]

1

[]

0

null

[ "Pseudomonadati", "ecological metagenomes" ]

[ 193, 4 ]

2

[]

0

true

Family

RcgR-like

9

IPR058112

58,112

CD3337/EF1877-like

CD3337_EF1877-like

Family

1,385

false

Members of this family regularly are found in mobile elements. Only the N-terminal 450 amino acids are well-conserved. That portion is strongly hydrophobic and the proteins are predicted to embed in the membrane. Members of this family appear to distantly related to TrbL/VirB6 family conjugal transfer proteins .

[]

0

[ "NCBIFAM" ]

[ "NF046089" ]

[ "CD3337_EF1877" ]

[ 1385 ]

1

[]

0

[]

0

[ "PUB00159560", "PUB00159561" ]

[ "21097591", "31666016" ]

[ "Diversity of the fsr-gelE region of the Enterococcus faecalis genome but conservation in strains with partial deletions of the fsr operon.", "Microevolution within ST11 group Clostridioides difficile isolates through mobile genetic elements based on complete genome sequencing." ]

[ 2011, 2019 ]

2

[]

0

null

[ "Bacteria", "Streptococcus phage IPP61", "metagenomes" ]

[ 1380, 1, 4 ]

3

[]

0

true

Family

CD3337/EF1877-like

CD3337_EF1877-like

3

IPR058113

58,113

Tryptophan biosynthesis modulator TrpM

TrpM_modulator

Family

532

false

TrpM (tryptophan biosynthesis modulator) is a predicted small protein encoded between trpC and trpB in many Streptomyces genomes [ , , ]. This entry represents its homologues found mainly in Streptomyces.

[]

0

[ "NCBIFAM", "PFAM" ]

[ "NF047334", "PF28284" ]

[ "modulat_TrpM", "TrpM_modulator" ]

[ 531, 532 ]

2

[]

0

[]

0

[ "PUB00159415", "PUB00159416", "PUB00159417" ]

[ "10361288", "27669158", "32140146" ]

[ "The expression of the trpD, trpC and trpBA genes of Streptomyces coelicolor A3(2) is regulated by growth rate and growth phase but not by feedback repression.", "TrpM, a Small Protein Modulating Tryptophan Biosynthesis and Morpho-Physiological Differentiation in Streptomyces coelicolor A3(2).", "The Strepto...

[ 1999, 2016, 2020 ]

3

[]

0

null

[ "Actinomycetes" ]

[ 532 ]

1

[]

0

true

Family

Tryptophan biosynthesis modulator TrpM

TrpM_modulator

9

IPR058114

58,114

RcgA-like

Family

209

false

RcgA (Rhizobial Conjugative Gene A), from a Rhizobium favelukesii plasmid, plays an essential role in a quorum-sensing-dependent conjugative transfer system. It is thought to be a transporter that allows uptake of a quorum-signalling lactone. Its partner protein, RgcR, with an α/β hydrolase domain, inhibits the transfe...

[]

0

[ "NCBIFAM", "PFAM" ]

[ "NF047336", "PF28285" ]

[ "conj_memb_RcgA", "RcgA" ]

[ 177, 209 ]

2

[]

0

[]

0

[ "PUB00159108" ]

[ "36073816" ]

[ "RcgA and RcgR, Two Novel Proteins Involved in the Conjugative Transfer of Rhizobial Plasmids." ]

[ 2022 ]

1

[]

0

null

[ "Pseudomonadati", "unclassified sequences" ]

[ 204, 5 ]

2

[]

0

true

Family

RcgA-like

2

IPR058115

58,115

Lmo0673

Family

32

false

In Listeria monocytogenes, lmo0673 is encoded immediately downstream of mogR in a bicistronic operon encoded divergently from flagellar genes. MogR is a transcriptional repressor essential for temperature-dependent transcription of flagellar genes. The gene lmo0673 is therefore considered the end gene of a large flagel...

[]

0

[ "NCBIFAM", "PFAM" ]

[ "NF047325", "PF28286" ]

[ "lmo0673_fam", "Lmo0673" ]

[ 32, 32 ]

2

[]

0

[]

0

[ "PUB00159312" ]

[ "32185833" ]

[ "Advances in bacterial transcriptome understanding: From overlapping transcription to the excludon concept." ]

[ 2020 ]

1

[]

0

null

[ "Listeria" ]

[ 32 ]

1

[]

0

true

Family

Lmo0673

1

IPR058116

58,116

SA0570-like

Family

137

false

The founding member of this mainly staphylococcal protein family, SA0570 Staphylococcus aureus, was listed as part of the core secretome of Staphylococcus aureus, that is, as a secreted protein found in more than 80% of strains. Being both secreted and well-conserved suggests SA0570 proteins may be virulence proteins [...

[]

0

[ "NCBIFAM", "PFAM" ]

[ "NF047391", "PF28288" ]

[ "SA0570_fam", "SA0570" ]

[ 129, 137 ]

2

[]

0

[]

0

[ "PUB00159835" ]

[ "20186749" ]

[ "Proteomics uncovers extreme heterogeneity in the Staphylococcus aureus exoproteome due to genomic plasticity and variant gene regulation." ]

[ 2010 ]

1

[]

0

null

[ "Bacteria", "human gut metagenome" ]

[ 136, 1 ]

2

[]

0

true

Family

SA0570-like

9

IPR058117

58,117

BV97_02767-like, proteobacterial type

BV97_02767_proteobact

Family

603

false

This entry represents uncharacterised proteins predominantly from proteobacteria. They are predicted to contain transmembrane helices. Members of this family are probably distantly related to .

[]

0

[ "NCBIFAM" ]

[ "NF006749" ]

[ "PRK09272.1-2" ]

[ 603 ]

1

[]

0

[]

0

[]

0

[ "IPR060701" ]

[]

1

0

1

[ "Bacteria", "Eukaryota", "ecological metagenomes" ]

[ 581, 2, 20 ]

3

[]

0

true

Family

BV97_02767-like, proteobacterial type

BV97_02767_proteobact

8

IPR058118

58,118

Telomere-protecting terminal protein Tpg

Tpg

Family

1,073

false

Tpg (terminal protein gene) and Tap (telomere-associated protein) together act to maintain the linear topology and telomere regions of the linear chromosome, and some linear plasmids, in Streptomyces and a few related bacteria. These proteins are covalently bound to the 5' ends of the DNA and the threonine in a motif T...

[]

0

[ "NCBIFAM" ]

[ "NF047541" ]

[ "telomere_Tpg" ]

[ 1073 ]

1

[]

0

[]

0

[ "PUB00159592" ]

[ "23457549" ]

[ "Mutational analysis of the terminal protein Tpg of Streptomyces chromosomes: identification of the deoxynucleotidylation site." ]

[ 2013 ]

1

[]

0

null

[ "Actinomycetes" ]

[ 1073 ]

1

[]

0

true

Family

Telomere-protecting terminal protein Tpg

Tpg

1

IPR058119

58,119

SCO0607-like

Family

250

false

This entry represents the homologues of SCO0607 lipoprotein. The lipoprotein SCO0607 of Streptomyces coelicolor ( ), along with a number of morphogenic membrane proteins, is regulated by the response regulator transcription factor MarR (SCO2120) . Related lipoproteins are found in a large number of Streptomyces species...

[]

0

[ "NCBIFAM", "PFAM" ]

[ "NF046120", "PF28290" ]

[ "lipo_SCO0607", "SCO0607" ]

[ 240, 250 ]

2

[]

0

[]

0

[ "PUB00159414" ]

[ "30530707" ]

[ "Novel Two-Component System MacRS Is a Pleiotropic Regulator That Controls Multiple Morphogenic Membrane Protein Genes in Streptomyces coelicolor." ]

[ 2019 ]

1

[]

0

null

[ "Actinomycetes" ]

[ 250 ]

1

[]

0

true

Family

SCO0607-like

1

IPR058120

58,120

Methylation-associated defense system protein MAD7

MADS7

Family

353

false

This entry represents the methylation-associated defense system protein MAD7 and related proteins. The methylation-associated defense system (MADS) is distributed across gram-positive and gram-negative bacteria. MADS interacts with a CRISPR-Cas system in its native host to provide robust and durable resistance against ...

[]

0

[ "NCBIFAM", "PFAM" ]

[ "NF047733", "PF26611" ]

[ "antiphage_MADS7", "MAD7" ]

[ 226, 353 ]

2

[]

0

[]

0

[ "PUB00159606" ]

[ "39094583" ]

[ "The bacterial defense system MADS interacts with CRISPR-Cas to limit phage infection and escape." ]

[ 2024 ]

1

[]

0

null

[ "Bacteria", "Haloarcula nitratireducens", "Nematostella vectensis", "metagenomes" ]

[ 347, 1, 1, 4 ]

4

[]

0

true

Family

Methylation-associated defense system protein MAD7

MADS7

9

IPR058121

58,121

Exodeoxyribonuclease WalJ/YycJ

WalJ/YycJ

Family

2,600

false

This entry represents Exodeoxyribonuclease WalJ/YycJ from Streptococcus pneumoniae and similar 5'->3' double-stranded DNA exonucleases predominantly found in bacilli. Members of this family are involved in the WalK/WalR signal transduction pathway [ ] and may contribute to mutation mismatch repair (MMR) [ ]. They play ...

[]

0

[ "CDD" ]

[ "cd07733" ]

[ "YycJ-like_MBL-fold" ]

[ 2600 ]

1

[ "EC" ]

[ "3.1.11.-" ]

[ "EC:3.1.11.-" ]

1

[]

0

[ "PUB00001273", "PUB00004473", "PUB00085867", "PUB00087023", "PUB00087024", "PUB00153385", "PUB00160970", "PUB00160971" ]

[ "7588620", "9108146", "11513844", "11471246", "17597585", "14651645", "21169496", "23491602" ]

[ "The 3-D structure of a zinc metallo-beta-lactamase from Bacillus cereus reveals a new type of protein fold.", "Extracting protein alignment models from the sequence database.", "Expansion of the zinc metallo-hydrolase family of the beta-lactamase fold.", "An evolutionary classification of the metallo-beta-la...

[ 1995, 1997, 2001, 1999, 2007, 2003, 2011, 2013 ]

8

[ "IPR052533" ]

[]

1

0

1

[ "Bacteria", "Methanomicrobiales", "Opisthokonta", "Siphoviridae sp. ctCCX1", "metagenomes" ]

[ 2566, 28, 3, 1, 2 ]

5

[]

0

true

Family

Exodeoxyribonuclease WalJ/YycJ

WalJ/YycJ

7

IPR058122

58,122

Transcriptional regulatory protein CpxR

CpxR

Family

1,068

false

This entry represents Transcriptional regulatory protein CpxR from Klebsiella pneumoniae and similar proteins from enterobacterales. CpxR is a member of the two-component regulatory system CpxA/CpxR which responds to envelope stress response by activating or, in some cases, repressing expression of downstream genes [ ,...

[]

0

[ "NCBIFAM" ]

[ "NF008199" ]

[ "PRK10955.1" ]

[ 1068 ]

1

[]

0

[]

0

[ "PUB00104694", "PUB00160972", "PUB00160973" ]

[ "24184210", "22496764", "36898943" ]

[ "Everything old is new again: an update on current research on the Cpx envelope stress response.", "Role of the two component signal transduction system CpxAR in conferring cefepime and chloramphenicol resistance in Klebsiella pneumoniae NTUH-K2044.", "Role of the stress-responsive two-component system CpxAR in...

[ 2014, 2012, 2023 ]

3

[ "IPR039420" ]

[]

1

0

1

[ "Bacteria", "Opisthokonta", "human gut metagenome" ]

[ 1063, 4, 1 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Transcriptional regulatory protein CpxR

CpxR

4

IPR058123

58,123

FlcA, N-terminal

FlcA_N

Domain

108

false

This entry represents the N-terminal region in FlcA. In spirochetes, flagella are located within the periplasm. FlcA is one of several structural proteins involved in the formation of the flagellar collar. The conserved N-terminal domain of about 40 amino acids and the C-terminal region domain of about 650 amino acids ...

[]

0

[ "NCBIFAM" ]

[ "NF047372" ]

[ "FlcA_NTERM" ]

[ 108 ]

1

[]

0

[]

0

[ "PUB00159294" ]

[ "31743518" ]

[ "BB0326 is responsible for the formation of periplasmic flagellar collar and assembly of the stator complex in Borrelia burgdorferi." ]

[ 2020 ]

1

[]

0

null

[ "Bacteria", "Menopon gallinae" ]

[ 107, 1 ]

2

[]

0

true

Domain

FlcA, N-terminal

FlcA_N

4

IPR058124

58,124

CpxR-like, receiver domain

CpxR-like_REC

Domain

3,366

false

This entry represents the N-terminal receiver (REC) domain of Transcriptional regulatory protein CpxR from Klebsiella pneumoniae and similar proteins mainly from gammaproteobacteria. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multist...

[]

0

[ "CDD" ]

[ "cd17623" ]

[ "REC_OmpR_CpxR" ]

[ 3366 ]

1

[]

0

[]

0

[ "PUB00053583", "PUB00107112", "PUB00143203", "PUB00143640", "PUB00143641", "PUB00160972", "PUB00160973" ]

[ "16740923", "20226724", "25294881", "16861804", "14623071", "22496764", "36898943" ]

[ "Structural classification of bacterial response regulators: diversity of output domains and domain combinations.", "Diversity of structure and function of response regulator output domains.", "The CpxR/CpxA two-component regulatory system up-regulates the multidrug resistance cascade to facilitate Escherichia ...

[ 2006, 2010, 2014, 2006, 2003, 2012, 2023 ]

7

[ "IPR001789" ]

[]

1

0

1

[ "Bacteria", "Opisthokonta", "Thermococcus litoralis", "metagenomes" ]

[ 3344, 2, 1, 19 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Domain

CpxR-like, receiver domain

CpxR-like_REC

1

IPR058125

58,125

Sensor histidine kinase CpxA

CpxA

Family

1,702

false

This entry represents Sensor histidine kinase CpxA from Vibrio parahaemolyticus [ ], Klebsiella pneumoniae [ ], and similar proteins from gammaproteobacteria. The Cpx system is one of extracytoplasmic stress response systems (ESR) found in Gram-negative bacteria. ESRs are operated by a two-component signalling system w...

[ "GO:0000155", "GO:0007165" ]

[ "phosphorelay sensor kinase activity", "signal transduction" ]

[ "molecular_function", "biological_process" ]

2

[ "NCBIFAM" ]

[ "NF007007" ]

[ "PRK09470.1" ]

[ 1702 ]

1

[ "EC" ]

[ "2.7.13.3" ]

[ "EC:2.7.13.3" ]

1

[ "4biu", "4biv", "4biw", "4bix", "4biy", "4biz", "4cb0", "5lfk" ]

8

[ "PUB00076304", "PUB00104404", "PUB00104405", "PUB00104406", "PUB00160973" ]

[ "22760860", "15576781", "15629938", "3058985", "36898943" ]

[ "The crystal structure of the periplasmic domain of Vibrio parahaemolyticus CpxA.", "Negative regulation of DNA repair gene (ung) expression by the CpxR/CpxA two-component system in Escherichia coli K-12 and induction of mutations by increased expression of CpxR.", "The Cpx envelope stress response affects expr...

[ 2012, 2004, 2005, 1988, 2023 ]

5

[ "IPR050398" ]

[]

1

0

1

[ "Bacteria", "Opisthokonta", "human gut metagenome" ]

[ 1698, 3, 1 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Sensor histidine kinase CpxA

CpxA

4

IPR058127

58,127

DedA

Family

4,493

false

This entry represents the DedA family protein from Klebsiella pneumoniae and similar bacterial sequences. DedA may be involved in undecaprenyl phosphate (UndP) transport and recycling [ ]. It is involved in biosynthesis of LPS lipid A and in the maintenance of membrane potential and plays a role in virulence, probably ...

[]

0

[ "NCBIFAM" ]

[ "NF008102" ]

[ "PRK10847.1" ]

[ 4493 ]

1

[]

0

[]

0

[ "PUB00153389", "PUB00160979", "PUB00160980" ]

[ "36450357", "31988174", "34934166" ]

[ "Two broadly conserved families of polyprenyl-phosphate transporters.", "Transposon Mutagenesis Screen of Klebsiella pneumoniae Identifies Multiple Genes Important for Resisting Antimicrobial Activities of Neutrophils in Mice.", "A Klebsiella pneumoniae DedA family membrane protein is required for colistin resi...

[ 2023, 2020, 2021 ]

3

[ "IPR032818" ]

[]

1

0

1

[ "Bacteria", "Eukaryota", "Methanobacteriota", "unclassified sequences" ]

[ 4423, 42, 11, 17 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

DedA

8

IPR058129

58,129

Phosphatidylethanolamine transferase Mcr-2

Mcr2

Family

3

false

This entry represents Phosphatidylethanolamine transferase Mcr-2 from Escherichia coli (Mcr2) and similar sequences from bacteria. Mcr-2 is thought to catalyse the addition of a phosphoethanolamine moiety to lipid A [ ]. It was found that it confers resistance to polymyxin-type antibiotics such as colistin [ ].

[]

0

[ "NCBIFAM" ]

[ "NF012159" ]

[ "polymyxin_MCR2" ]

[ 3 ]

1

[]

0

[]

0

[ "PUB00160982" ]

[ "30194678" ]

[ "Structural and functional insights into MCR-2 mediated colistin resistance." ]

[ 2018 ]

1

[ "IPR040423" ]

[]

1

0

1

[ "Gammaproteobacteria" ]

[ 3 ]

1

[]

0

true

Family

Phosphatidylethanolamine transferase Mcr-2

Mcr2

6

IPR058130

58,130

Phosphoethanolamine transferase, C-terminal domain

PEA_transf_C

Domain

13,462

false

This entry represents the C-terminal domain of phosphoethanolamine (PEA) transferases mainly found in proteobacteria. The enzyme EptA (also known as LptA, ) promotes phosphoethanolamine (PEA) decoration of lipid A, which promotes resistance to innate defence systems [ , ]. In addition to lipid A PEA transferases, many ...

[]

0

[ "CDD" ]

[ "cd16017" ]

[ "LptA" ]

[ 13462 ]

1

[]

0

[ "4kav", "4kay", "4tn0", "5fgn", "5gov", "5grr", "5k4p", "5lrm", "5lrn", "5mx9", "5ylc", "5yle", "5ylf", "5zjv", "5zzu", "6a7w", "6a82", "6a83", "6bnc", "6bnd", "6bne", "6bnf", "6li4", "6li5", "6li6", "6sut", "7waa", "7yjp", "7yjq", "7yjr", "7yjs", "7yjt"...

32

[ "PUB00007922", "PUB00010629", "PUB00024501", "PUB00077024", "PUB00090933", "PUB00090934", "PUB00090935", "PUB00090936", "PUB00135836", "PUB00135837", "PUB00135838", "PUB00160981" ]

[ "10958932", "1525473", "10873454", "23748343", "12694188", "30186254", "28342805", "26603172", "18824535", "23810904", "19114544", "29079699" ]

[ "Structure, function, and evolution of phosphoglycerate mutases: comparison with fructose-2,6-bisphosphatase, acid phosphatase, and alkaline phosphatase.", "Structure and mechanism of alkaline phosphatase.", "A revised mechanism for the alkaline phosphatase reaction involving three metal ions.", "Fortifying t...

[ 2000, 1992, 2000, 2013, 2003, 2018, 2017, 2016, 2008, 2013, 2009, 2018 ]

12

[ "IPR000917" ]

[]

1

0

1

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 13351, 14, 97 ]

3

[ "Escherichia coli (strain K12)" ]

[ 5 ]

1

true

Domain

Phosphoethanolamine transferase, C-terminal domain

PEA_transf_C

9

IPR058131

58,131

Beta-lactamase CTX-M

Cefotaximase

Family

863

false

This entry represents a group of class A beta-lactamase CTX-M (Cefotaximase) enzymes from gammaproteobacteria, including beta-lactamase CTX-M-15 from Escherichia coli (BLC15). This extended-spectrum beta-lactamase confers resistance to penicillins, as well as first, second, third and fourth-generation cephalosporins an...

[ "GO:0008800" ]

[ "beta-lactamase activity" ]

[ "molecular_function" ]

1

[ "NCBIFAM" ]

[ "NF033089" ]

[ "blaCTX-M" ]

[ 863 ]

1

[ "EC" ]

[ "3.5.2.6" ]

[ "EC:3.5.2.6" ]

1

[ "1bza", "1iyo", "1iyp", "1iyq", "1iys", "1we4", "1ylj", "1ylp", "1ylt", "1ylw", "1yly", "1ylz", "1ym1", "1yms", "1ymx", "2p74", "2xqz", "2xr0", "2zq7", "2zq8", "2zq9", "2zqa", "2zqc", "2zqd", "3g2y", "3g2z", "3g30", "3g31", "3g32", "3g34", "3g35", "3zny"...

192

[ "PUB00160983", "PUB00160984", "PUB00160985", "PUB00160986", "PUB00160987" ]

[ "28069651", "29941650", "34310213", "35515906", "35563620" ]

[ "Inhibition by Avibactam and Clavulanate of the β-Lactamases KPC-2 and CTX-M-15 Harboring the Substitution N132G in the Conserved SDN Motif.", "Combination of Amino Acid Substitutions Leading to CTX-M-15-Mediated Resistance to the Ceftazidime-Avibactam Combination.", "Mechanisms Involved in the Activ...

[ 2017, 2018, 2021, 2019, 2022 ]

5

[ "IPR000871" ]

[]

1

0

1

[ "Bacteria", "Salmonella phage SJ46", "uncultured organism" ]

[ 861, 1, 1 ]

3

[]

0

true

Family

Beta-lactamase CTX-M

Cefotaximase

9

IPR058133

58,133

Redox-sensing transcriptional repressor Rex, streptococcus

Rex_streptococcus

Family

376

false

This entry represents Redox-sensing transcriptional repressor Rex from Streptococcus pneumoniae and similar sequences. Rex modulates transcription in response to changes in cellular NADH/NAD+ redox state and binds to the promoter of the aldehyde-alcohol dehydrogenase adhE gene [ ]. This family is specific to Streptococ...

[]

0

[ "NCBIFAM" ]

[ "NF003988" ]

[ "PRK05472.1-1" ]

[ 376 ]

1

[]

0

[ "3keo", "3keq", "3ket" ]

3

[ "PUB00160990" ]

[ "25312953" ]

[ "Ethanol-induced alcohol dehydrogenase E (AdhE) potentiates pneumolysin in Streptococcus pneumoniae." ]

[ 2015 ]

1

[ "IPR058203" ]

[]

1

0

1

[ "Bacteria" ]

[ 376 ]

1

[]

0

true

Family

Redox-sensing transcriptional repressor Rex, streptococcus

Rex_streptococcus

8

IPR058134

58,134

Ferric enterobactin receptor PirA/FepA/PfeA

PirA/FepA/PfeA

Family

3,518

false

This protein family includes Ferric enterobactin receptor PirA from Acinetobacter baumannii, FepA from Escherichia coli K-12, PfeA from Pseudomonas aeruginosa, and similar TonB-dependent receptors for the ferric-bound form of the siderophore enterobactin (enterochelin). PirA is thought to be involved in the initial ste...

[ "GO:0015344", "GO:0015891" ]

[ "siderophore uptake transmembrane transporter activity", "siderophore transport" ]

[ "molecular_function", "biological_process" ]

2

[ "NCBIFAM" ]

[ "NF010048" ]

[ "PRK13524.1" ]

[ 3518 ]

1

[ "REACTOME" ]

[ "R-HSA-9638334" ]

[ "REACTOME:R-HSA-9638334" ]

1

[ "1fep", "5fp2", "5fr8", "5m9b", "5mzs", "5nc3", "5nc4", "5nr2", "5out", "6i2j", "6q5e", "6r1f", "6y47", "6yy5", "6z2n", "6z33", "7obw" ]

17

[ "PUB00002420", "PUB00104901", "PUB00160991", "PUB00160992" ]

[ "3015941", "8419284", "28137795", "35101443" ]

[ "Nucleotide sequence of the gene for the ferrienterochelin receptor FepA in Escherichia coli. Homology among outer membrane receptors that interact with TonB.", "Cloning and characterization of the ferric enterobactin receptor gene (pfeA) of Pseudomonas aeruginosa.", "Structure and Function of the PiuA and PirA...

[ 1986, 1993, 2017, 2022 ]

4

[ "IPR010105" ]

[]

1

0

1

[ "Bacteria", "leotiomyceta", "plant metagenome" ]

[ 3508, 2, 8 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Ferric enterobactin receptor PirA/FepA/PfeA

PirA/FepA/PfeA

2

IPR058135

58,135

Transcriptional regulator RamA, enterobacterales

RamA_enterobacterales

Family

593

false

This entry represents Transcriptional regulator RamA from Salmonella typhimurium and similar proteins from enterobacterales. RamA binds to regulatory regions of target genes, including efflux pump operon acrAB, probably conferring multidrug resistance; outer membrane protein gene tolC [ , , ]; and genes belonging to th...

[]

0

[ "NCBIFAM" ]

[ "NF012144" ]

[ "ramA_TF" ]

[ 593 ]

1

[]

0

[ "7bef", "7beg" ]

2

[ "PUB00154566", "PUB00160993", "PUB00160994", "PUB00160995" ]

[ "31501286", "18577510", "18694955", "20081028" ]

[ "Multidrug Resistance Regulators MarA, SoxS, Rob, and RamA Repress Flagellar Gene Expression and Motility in Salmonella enterica Serovar Typhimurium.", "AcrAB multidrug efflux pump regulation in Salmonella enterica serovar Typhimurium by RamA in response to environmental signals.", "RamA confers multidrug resis...

[ 2019, 2008, 2008, 2010 ]

4

[ "IPR050959" ]

[]

1

0

1

[ "Gammaproteobacteria", "Timema poppense" ]

[ 592, 1 ]

2

[]

0

true

Family

Transcriptional regulator RamA, enterobacterales

RamA_enterobacterales

8

IPR058136

58,136

Beta-lactamase AmpC

AmpC

Family

4,237

false

This family includes Beta-lactamase AmpC from Escherichia coli and similar beta-lactamases of Ambler class C. Essentially all are active against cephalosporin class beta-lactams. AmpC confers resistance to penicillins and cephalosporins [ , , , , ]. Many of these enzymes have been picked up by mobile elements such as p...

[]

0

[ "NCBIFAM" ]

[ "NF033085" ]

[ "bla_class_C" ]

[ 4237 ]

1

[ "EC" ]

[ "3.5.2.6" ]

[ "EC:3.5.2.6" ]

1

[ "1bls", "1c3b", "1fcm", "1fcn", "1fco", "1fr1", "1fr6", "1fsw", "1fsy", "1ga0", "1ga9", "1gce", "1i5q", "1iel", "1iem", "1kds", "1kdw", "1ke0", "1ke3", "1ke4", "1kvl", "1kvm", "1l0d", "1l0e", "1l0f", "1l0g", "1l2s", "1ll5", "1ll9", "1llb", "1mxo", "1my8"...

263

[ "PUB00022081", "PUB00047681", "PUB00064085", "PUB00160999", "PUB00161000" ]

[ "12323371", "17956081", "23043117", "33199391", "6998377" ]

[ "Using steric hindrance to design new inhibitors of class C beta-lactamases.", "Optimizing cell permeation of an antibiotic resistance inhibitor for improved efficacy.", "Fragment-guided design of subnanomolar β-lactamase inhibitors active in vivo.", "Structural Investigations of the Inhibition of Escherichia...

[ 2002, 2007, 2012, 2021, 1980 ]

5

[ "IPR050491" ]

[ "IPR058140", "IPR058142", "IPR058164", "IPR058221" ]

1

4

0

[ "Bacteria", "unclassified sequences" ]

[ 4224, 13 ]

2

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Beta-lactamase AmpC

AmpC

9

IPR058137

58,137

Beta-lactamase VEB-1

VEB-1

Family

57

false

VEB signifies Vietnam Extended-spectrum Beta-lactamase. Members of this protein family, which includes Beta-lactamase VEB-1 from Pseudomonas aeruginosa [ ], are highly conserved variants of recently mobilised class A beta-lactamases that confer resistance to a number of clinically important cephalosporin-class beta-lac...

[ "GO:0008800" ]

[ "beta-lactamase activity" ]

[ "molecular_function" ]

1

[ "NCBIFAM" ]

[ "NF000390" ]

[ "blaVEB" ]

[ 57 ]

1

[]

0

[]

0

[ "PUB00104014", "PUB00104015" ]

[ "10049269", "26926646" ]

[ "Molecular and biochemical characterization of VEB-1, a novel class A extended-spectrum beta-lactamase encoded by an Escherichia coli integron gene.", "Identification of Novel VEB β-Lactamase Enzymes and Their Impact on Avibactam Inhibition." ]

[ 1999, 2016 ]

2

[ "IPR000871" ]

[]

1

0

1

[ "Pseudomonadati" ]

[ 57 ]

1

[]

0

true

Family

Beta-lactamase VEB-1

VEB-1

4

IPR058138

58,138

Beta-lactamase BlaZ

BlaZ

Family

123

false

This entry represents a group of beta-lactamases from various Staplilococcus species, including Beta-lactamase BlaZ from Staphylococcus aureus, which is encoded on plasmid pI258 [ ].

[ "GO:0008800" ]

[ "beta-lactamase activity" ]

[ "molecular_function" ]

1

[ "NCBIFAM" ]

[ "NF033141" ]

[ "blaZ_gen" ]

[ 123 ]

1

[]

0

[]

0

[ "PUB00161001" ]

[ "3104315" ]

[ "Nucleotide sequence and expression of the beta-lactamase gene from Staphylococcus aureus plasmid pI258 in Escherichia coli, Bacillus subtilis, and Staphylococcus aureus." ]

[ 1987 ]

1

[ "IPR000871" ]

[]

1

0

1

[ "Bacteria" ]

[ 123 ]

1

[]

0

true

Family

Beta-lactamase BlaZ

BlaZ

8

IPR058139

58,139

Beta-lactamase BlaC, bacilli

BlaC_bacilli

Family

739

false

This entry represents a group of beta-lactamases from Bacilli, including beta-lactamase BlaC from Bacillus subtilis.

[ "GO:0008800" ]

[ "beta-lactamase activity" ]

[ "molecular_function" ]

1

[ "NCBIFAM" ]

[ "NF012167" ]

[ "classA_firm" ]

[ 739 ]

1

[ "EC" ]

[ "3.5.2.6" ]

[ "EC:3.5.2.6" ]

1

[ "1i2s", "1i2w", "1mbl", "1w7f", "2blm", "2wk0", "2x71", "2y91", "3b3x", "3ly3", "3ly4", "3m2j", "3m2k", "3qhy", "3sh7", "3sh8", "3sh9", "3soi", "4a5r", "4blm", "4m3k", "4n1h", "4n92", "4n9k", "4n9l", "5ghx", "5ghy", "5ghz", "5lwf", "5zfl", "5zft", "5zg6"...

37

[]

0

[ "IPR000871" ]

[ "IPR058143" ]

1

0

[ "Bacteria" ]

[ 739 ]

1

[]

0

true

Family

Beta-lactamase BlaC, bacilli

BlaC_bacilli

5

IPR058140

58,140

Beta-lactamase AmpC, escherichia-type

AmpC_escherichia-type

Family

225

false

This entry represents a group of beta-lactamases from escherichia and shigella species, including AmpC from Escherichia coli, which confers resistance to penicillins and cephalosporins [ , , , , ]. The chromosomal class C beta-lactamase (AmpC) of Escherichia coli has the species-specific gene symbol blaEC. It is normal...

[]

0

[ "NCBIFAM" ]

[ "NF000185" ]

[ "BlaEC" ]

[ 225 ]

1

[]

0

[ "1c3b", "1fco", "1fsw", "1fsy", "1ga9", "1i5q", "1iel", "1iem", "1kds", "1kdw", "1ke0", "1ke3", "1ke4", "1kvl", "1kvm", "1l0d", "1l0e", "1l0f", "1l0g", "1l2s", "1ll5", "1ll9", "1llb", "1mxo", "1my8", "1pi4", "1pi5", "1xgi", "1xgj", "2bls", "2ffy", "2hdq"...

120

[ "PUB00022081", "PUB00047681", "PUB00064085", "PUB00103994", "PUB00160999", "PUB00161000" ]

[ "12323371", "17956081", "23043117", "16801449", "33199391", "6998377" ]

[ "Using steric hindrance to design new inhibitors of class C beta-lactamases.", "Optimizing cell permeation of an antibiotic resistance inhibitor for improved efficacy.", "Fragment-guided design of subnanomolar β-lactamase inhibitors active in vivo.", "Naturally occurring extended-spectrum cephalosporinases in...

[ 2002, 2007, 2012, 2006, 2021, 1980 ]

6

[ "IPR058136" ]

[]

1

0

1

[ "Bacteria" ]

[ 225 ]

1

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Beta-lactamase AmpC, escherichia-type

AmpC_escherichia-type

8

IPR058142

58,142

Beta-lactamase AmpC, enterobacter

AmpC_enterobacter

Family

242

false

This entry represents a group of beta-lactamases from enterobacter, including AmpC from Enterobacter cloacae, a serine beta-lactamase with a substrate specificity for cephalosporins.

[]

0

[ "NCBIFAM" ]

[ "NF000385" ]

[ "blaACT" ]

[ 242 ]

1

[]

0

[ "1bls", "1ga0", "1gce", "1onh", "1q2q", "1rgz", "1s6r", "1xx2", "1y54", "2q9m", "2q9n", "2zc7", "3s4x", "4xux", "5hai", "5xhr", "7ti1" ]

17

[ "PUB00104011" ]

[ "17005822" ]

[ "High-level carbapenem resistance in a Klebsiella pneumoniae clinical isolate is due to the combination of bla(ACT-1) beta-lactamase production, porin OmpK35/36 insertional inactivation, and down-regulation of the phosphate transport porin phoe." ]

[ 2006 ]

1

[ "IPR058136" ]

[]

1

0

1

[ "Enterobacterales" ]

[ 242 ]

1

[]

0

true

Family

Beta-lactamase AmpC, enterobacter

AmpC_enterobacter

8

IPR058143

58,143

Beta-lactamase 3, bacillus

Bla3_bacillus

Family

106

false

Members of this family of class A beta-lactamases, including the founding member from Bacillus cereus, are now referred to as BlaIII (or Bla3), as the symbol blaZ now far refers much more frequently to a distantly related class A enzyme from Staphylococcus. BlaIII has a lipoprotein-type signal peptide and is membrane-a...

[ "GO:0008800" ]

[ "beta-lactamase activity" ]

[ "molecular_function" ]

1

[ "NCBIFAM" ]

[ "NF041270" ]

[ "bla_Bcer_III" ]

[ 106 ]

1

[]

0

[]

0

[ "PUB00104996", "PUB00106281", "PUB00106282" ]

[ "26511485", "3027036", "6414514" ]

[ "A Structure-Based Classification of Class A β-Lactamases, a Broadly Diverse Family of Enzymes.", "Cloning and sequencing of the blaZ gene encoding beta-lactamase III, a lipoprotein of Bacillus cereus 569/H.", "Characterization of the membrane beta-lactamase in Bacillus cereus 569/H/9." ]

[ 2016, 1987, 1983 ]

3

[ "IPR058139" ]

[]

1

0

1

[ "Bacillus cereus group" ]

[ 106 ]

1

[]

0

true

Family

Beta-lactamase 3, bacillus

Bla3_bacillus

6

IPR058144

58,144

Multiple antibiotic resistance protein MarA

MarA

Family

713

false

This entry represents Multiple antibiotic resistance protein MarA from Salmonella typhimurium and similar proteins from enterobacterales. MarA represses transcription of genes belonging to the flagellar regulon, including flhD, flhB and fliC; probably thereby leading to repression of motility [ ].

[]

0

[ "NCBIFAM" ]

[ "NF008564" ]

[ "PRK11511.1" ]

[ 713 ]

1

[]

0

[ "1bl0", "1xs9" ]

2

[ "PUB00154566" ]

[ "31501286" ]

[ "Multidrug Resistance Regulators MarA, SoxS, Rob, and RamA Repress Flagellar Gene Expression and Motility in Salmonella enterica Serovar Typhimurium." ]

[ 2019 ]

1

[ "IPR050959" ]

[]

1

0

1

[ "Gammaproteobacteria" ]

[ 713 ]

1

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Multiple antibiotic resistance protein MarA

MarA

8

IPR058145

58,145

Dihydropteroate synthase type-2

Sul2

Family

453

false

This entry represents Dihydropteroate synthase type-2 from Escherichia coli (Sul2) and similar proteins mainly found in proteobacteria. Sul2 catalyses the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor o...

[ "GO:0004156" ]

[ "dihydropteroate synthase activity" ]

[ "molecular_function" ]

1

[ "NCBIFAM" ]

[ "NF000295" ]

[ "Sul2" ]

[ 453 ]

1

[]

0

[ "7s2j", "7s2k" ]

2

[ "PUB00161002" ]

[ "37419898" ]

[ "Molecular mechanism of plasmid-borne resistance to sulfonamide antibiotics." ]

[ 2023 ]

1

[ "IPR045031" ]

[]

1

0

1

[ "Bacteria", "Trichuris trichiura", "human gut metagenome" ]

[ 451, 1, 1 ]

3

[]

0

true

Family

Dihydropteroate synthase type-2

Sul2

5

IPR058147

58,147

Right origin-binding protein

Rob

Family

1,195

false

This entry represents Right origin-binding protein from Escherichia coli (Rob) and similar proteins from gammaproteobacteria. Rob is a transcriptional regulator that binds to the right arm of the replication origin oriC of the chromosome, which may influence the formation of the nucleoprotein structure, required for or...

[ "GO:0043565", "GO:0006355" ]

[ "sequence-specific DNA binding", "regulation of DNA-templated transcription" ]

[ "molecular_function", "biological_process" ]

2

[ "NCBIFAM" ]

[ "NF012228" ]

[ "RobA_TF" ]

[ 1195 ]

1

[]

0

[ "1d5y", "7vwy", "7vwz" ]

3

[ "PUB00161004" ]

[ "8449900" ]

[ "A novel binding protein of the origin of the Escherichia coli chromosome." ]

[ 1993 ]

1

[ "IPR050959" ]

[]

1

0

1

[ "Bacteria", "Trichuris trichiura" ]

[ 1194, 1 ]

2

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Right origin-binding protein

Rob

3

IPR058148

58,148

M949_RS01915-like domain

M949_RS01915-like_dom

Domain

807

false

This entry represents a domain found in M949_RS01915 from the Gram-negative duck pathogen Riemerella anatipestifer and similar proteins. Disruption of the gene encoding this protein causes a defect in lipopolysaccharide (LPS) structure with altered serology and apparent changes in O-antigen structure [ ]. Homologues ar...

[]

0

[ "NCBIFAM" ]

[ "NF046077" ]

[ "LPS_M949_RS01915" ]

[ 807 ]

1

[]

0

[]

0

[ "PUB00159557" ]

[ "28166822" ]

[ "Disruption of the M949_RS01915 gene changed the bacterial lipopolysaccharide pattern, pathogenicity and gene expression of Riemerella anatipestifer." ]

[ 2017 ]

1

[]

0

null

[ "Bacteria", "bioreactor metagenome" ]

[ 806, 1 ]

2

[]

0

true

Domain

M949_RS01915-like domain

M949_RS01915-like_dom

3

IPR058149

58,149

Photosystem II assembly protein Psb35

Psb35

Family

370

false

This entry represents Psb35 from cyanobacterium Synechocystis sp. PCC 6803 (Ssl2148, ) and related proteins from cyanobacteria. Psb35 is a component of the CP47 antenna module of Photosystem II [ ]. This protein stabilises the CP47 assembly module and associated high-light inducible proteins during the biogenesis of Ph...

[]

0

[ "NCBIFAM", "PFAM" ]

[ "NF047378", "PF26623" ]

[ "photo_II_Psb35", "Psb35" ]

[ 370, 370 ]

2

[]

0

[]

0

[ "PUB00159047" ]

[ "33258963" ]

[ "Psb35 Protein Stabilizes the CP47 Assembly Module and Associated High-Light Inducible Proteins during the Biogenesis of Photosystem II in the Cyanobacterium Synechocystis sp. PCC6803." ]

[ 2021 ]

1

[]

0

null

[ "Cyanobacteriota" ]

[ 370 ]

1

[]

0

true

Family

Photosystem II assembly protein Psb35

Psb35

8

IPR058151

58,151

Beta-lactamase OXA-1

OXA-1

Family

150

false

This entry represents Beta-lactamase OXA-1 from Escherichia coli and similar proteins mainly found in gammaproteobacteria. OXA-1 is a class D beta-lactamase which confers resistance to the beta-lactam antibiotics, including amoxicillin and ticarcillin [ ]. It has penicillin- and cephalosporin-hydrolysing activities [ ,...

[]

0

[ "NCBIFAM" ]

[ "NF000388" ]

[ "blaOXA-1_like" ]

[ 150 ]

1

[]

0

[ "1m6k", "3isg", "4mll" ]

3

[ "PUB00161005", "PUB00161006", "PUB00161007" ]

[ "11353602", "19485421", "20086146" ]

[ "Oxacillinase-mediated resistance to cefepime and susceptibility to ceftazidime in Pseudomonas aeruginosa.", "Mutation of the active site carboxy-lysine (K70) of OXA-1 beta-lactamase results in a deacylation-deficient enzyme.", "Penicillin sulfone inhibitors of class D beta-lactamases." ]

[ 2001, 2009, 2010 ]

3

[]

0

null

[ "Bacteria" ]

[ 150 ]

1

[]

0

true

Family

Beta-lactamase OXA-1

OXA-1

6

IPR058152

58,152

Beta-lactamase, rhodobacterales

BlaC

Family

5

false

This entry represents a group of beta-lactamases from rhodobacterales, including beta-lactamase BlaC from Rhodobacter capsulatus [ ].

[ "GO:0008800" ]

[ "beta-lactamase activity" ]

[ "molecular_function" ]

1

[ "NCBIFAM" ]

[ "NF033466" ]

[ "blaRCP" ]

[ 5 ]

1

[]

0

[]

0

[ "PUB00000477" ]

[ "2788410" ]

[ "The phototrophic bacterium Rhodopseudomonas capsulata sp108 encodes an indigenous class A beta-lactamase." ]

[ 1989 ]

1

[ "IPR000871" ]

[]

1

0

1

[ "Rhodobacterales" ]

[ 5 ]

1

[]

0

true

Family

Beta-lactamase, rhodobacterales

BlaC

8

IPR058154

58,154

Phage Bxb1, tail tube protein-like

Bxb1_TTP-like

Family

2,255

false

This entry represents a family of phage tail tube proteins from a variety of phages and bacterial prophages, including Mycobacteriophage Bxb1. These proteins form homohexameric rings [ ]. The tail tube forms the inner channel of the contractile tail which is used for DNA transfer from the capsid to the host during infe...

[]

0

[ "PFAM" ]

[ "PF25681" ]

[ "Phage_TTP_17" ]

[ 2255 ]

1

[]

0

[ "9d93", "9d94", "9d9l" ]

3

[ "PUB00161008" ]

[ "40239650" ]

[ "Structure and infection dynamics of mycobacteriophage Bxb1." ]

[ 2025 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "Viruses", "metagenomes" ]

[ 1324, 2, 921, 8 ]

4

[]

0

true

Family

Phage Bxb1, tail tube protein-like

Bxb1_TTP-like

9

IPR058155

58,155

Skg3/CAF120-like, PH-like domain

Skg3/CAF120-like_PH

Domain

1,996

false

This entry represents the second pleckstrin homology (PH) domain found in fungal proteins including Skg3 and components of the CCR4-NOT complex such as CAF120 in Saccharomyces cerevisiae. SKG3 may play a role in cell wall integrity [ ]. This domain is found C-terminal to another PH domain.

[]

0

[ "PFAM" ]

[ "PF25381" ]

[ "PH_26" ]

[ 1996 ]

1

[]

0

[]

0

[ "PUB00161089" ]

[ "15645486" ]

[ "SKG1, a suppressor gene of synthetic lethality of kex2Deltagas1Delta mutations, encodes a novel membrane protein that affects cell wall composition." ]

[ 2005 ]

1

[]

0

null

[ "Opisthokonta" ]

[ 1996 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)" ]

[ 1, 3 ]

2

true

Domain

Skg3/CAF120-like, PH-like domain

Skg3/CAF120-like_PH

7

IPR058156

58,156

ZNF451, double C2H2 zinc finger domain

Znf-C2H2_ZNF451

Domain

1,224

false

This entry represents a domain consisting of two consecutive zinc fingers (of the C2H2 type), whose 4 β-strands are arranged antiparallel in a β-sheet. This domain is found in the E3 SUMO-protein ligase ZNF451 and similar proteins from vertebrates. ZNF451 is a key enzyme involved in the sumoylation process, exhibiting ...

[]

0

[ "PFAM" ]

[ "PF23108" ]

[ "Zf-C2H2_ZNF451" ]

[ 1224 ]

1

[]

0

[]

0

[ "PUB00117493", "PUB00120713", "PUB00120714" ]

[ "26524494", "24324267", "26524493" ]

[ "Structural basis for catalytic activation by the human ZNF451 SUMO E3 ligase.", "Zinc finger protein 451 is a novel Smad corepressor in transforming growth factor-β signaling.", "A new vertebrate SUMO enzyme family reveals insights into SUMO-chain assembly." ]

[ 2015, 2014, 2015 ]

3

[]

0

null

[ "Bilateria" ]

[ 1224 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 4, 3, 3, 4 ]

4

true

Domain

ZNF451, double C2H2 zinc finger domain

Znf-C2H2_ZNF451

2

IPR058157

58,157

Spectrin repeats, metazoan

Spectrin_met

Domain

880

false

This region of spectrin repeats is found in a group of uncharacterised proteins from animals.

[]

0

[ "PFAM" ]

[ "PF25101" ]

[ "Spectrin_7" ]

[ 880 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bilateria", "Nitrososphaerota" ]

[ 876, 4 ]

2

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster" ]

[ 1, 2, 8 ]

3

true

Domain

Spectrin repeats, metazoan

Spectrin_met

2

IPR058158

58,158

Phage FDXHR zinc binding domain

Phage_zn-bd_3

Domain

177

false

This entry represents a small family of uncharacterised phage proteins. According to structure predictions this domain contains two zinc binding clusters. This domain contains a highly conserved sequence motif FDXHR where X can be any amino acid.

[]

0

[ "PFAM" ]

[ "PF24071" ]

[ "Phage_zn_bind_3" ]

[ 177 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Viruses", "uncultured organism" ]

[ 105, 71, 1 ]

3

[]

0

true

Domain

Phage FDXHR zinc binding domain

Phage_zn-bd_3

2

IPR058159

58,159

Bacteriophage holin Pam3 gp28

Phage_holin_10

Family

157

false

This family includes Pam3 gp28 which is annotated as a phage holin. These proteins contain two predicted transmembrane helices.

[]

0

[ "PFAM" ]

[ "PF23987" ]

[ "Phage_holin_10" ]

[ 157 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Caudoviricetes", "ecological metagenomes" ]

[ 126, 29, 2 ]

3

[]

0

true

Family

Bacteriophage holin Pam3 gp28

Phage_holin_10

8

IPR058160

58,160

Beta-lactamase, streptomyces

BlaC_streptomyces

Family

9

false

This family of class A beta-lactamases includes BlaC (also named Exo because it is an exocellular protein) from Streptomyces albus, that is, it can be recovered from the culture medium [ ]. The exocellular trait is common for beta-lactamases of Gram-positive bacteria, but the name Exo is applied only to this narrow fam...

[ "GO:0008800" ]

[ "beta-lactamase activity" ]

[ "molecular_function" ]

1

[ "NCBIFAM" ]

[ "NF033099" ]

[ "bla_Exo" ]

[ 9 ]

1

[]

0

[]

0

[ "PUB00105008" ]

[ "6975618" ]

[ "The exocellular beta-lactamase of Streptomyces albus G. Purification, properties and comparison with the exocellular DD-carboxypeptidase." ]

[ 1981 ]

1

[ "IPR000871" ]

[]

1

0

1

[ "Streptomyces" ]

[ 9 ]

1

[]

0

true

Family

Beta-lactamase, streptomyces

BlaC_streptomyces

9

IPR058162

58,162

Beta-lactamase OXY-1/2

OXY-1/2

Family

103

false

This entry represents beta-lactamase OXY-1 from Klebsiella oxytoca and similar proteins from Klebsiella species. These enzymes hydrolyse broad-spectrum beta-lactam antibiotics and are active against cephalosporins.

[ "GO:0008800" ]

[ "beta-lactamase activity" ]

[ "molecular_function" ]

1

[ "NCBIFAM" ]

[ "NF000271" ]

[ "blaOXY" ]

[ 103 ]

1

[]

0

[ "3byd" ]

1

[]

0

[ "IPR000871" ]

[]

1

0

1

[ "Klebsiella" ]

[ 103 ]

1

[]

0

true

Family

Beta-lactamase OXY-1/2

OXY-1/2

9

IPR058163

58,163

LysR-type transcriptional regulator, proteobacterial-type

LysR-type_TF_proteobact-type

Family

206,563

false

This family of Lys-type transcriptional regulators includes AmpR from Pseudomonas aeruginosa and similar proteins predominantly found in proteobacteria. AmpR plays a critical role in the expression of beta-lactamase AmpC, acting by positive regulation of the ampC gene [ , , , ]. Members of this family are characterised...

[ "GO:0003700", "GO:0006355" ]

[ "DNA-binding transcription factor activity", "regulation of DNA-templated transcription" ]

[ "molecular_function", "biological_process" ]

2

[ "PANTHER" ]

[ "PTHR30537" ]

[ "" ]

[ 206563 ]

1

[]

0

[ "2qsx", "3hhf", "3hhg", "3kos", "3kot", "3mz1", "3szp", "3t1b", "4wkm", "5fhk", "5mmh", "5x0n", "5x0o", "7trv", "7trw", "8y6u", "9bce", "9hh1" ]

18

[ "PUB00086933", "PUB00161010", "PUB00161011", "PUB00161012" ]

[ "8405939", "16251297", "23045355", "25182487" ]

[ "Investigation of the Pseudomonas aeruginosa ampR gene and its role at the chromosomal ampC beta-lactamase promoter.", "Pseudomonas aeruginosa AmpR is a global transcriptional factor that regulates expression of AmpC and PoxB beta-lactamases, proteases, quorum sensing, and other virulence factors.", "Genetic ma...

[ 1993, 2005, 2012, 2014 ]

4

[]

[ "IPR011781", "IPR017786", "IPR049755" ]

0

3

0

[ "Bacteria", "Caudoviricetes", "Eukaryota", "Halorubrum tibetense", "Sym plasmid", "unclassified sequences" ]

[ 205364, 4, 269, 1, 4, 921 ]

6

[ "Escherichia coli (strain K12)" ]

[ 11 ]

1

true

Family

LysR-type transcriptional regulator, proteobacterial-type

LysR-type_TF_proteobact-type

6

IPR058164

58,164

Beta-lactamase AmpC, pseudomonas

AmpC_pseudomonas

Family

476

false

This entry represents a group of beta-lactamases from Pseudomonas species named PDC (Pseudomonas-Derived Cephalosporinase), including AmpC from Pseudomonas aeruginosa, which confers resistance to penicillins and cephalosporins and has nitrocefin-hydrolysing activity [ ]. PDC is a chromosomal AmpC, or class C beta-lacta...

[]

0

[ "NCBIFAM" ]

[ "NF000422" ]

[ "blaPDC" ]

[ 476 ]

1

[]

0

[ "2wzx", "2wzz", "3s1y", "3s22", "4gzb", "4nk3", "6s1s", "6uqs", "6uqt", "6uqu", "6ur3", "8sdl", "8sdn", "8sdr", "8sds", "8sdt", "8sdv", "9azu", "9azw", "9azy" ]

20

[ "PUB00161010" ]

[ "16251297" ]

[ "Pseudomonas aeruginosa AmpR is a global transcriptional factor that regulates expression of AmpC and PoxB beta-lactamases, proteases, quorum sensing, and other virulence factors." ]

[ 2005 ]

1

[ "IPR058136" ]

[]

1

0

1

[ "Pseudomonas" ]

[ 476 ]

1

[]

0

true

Family

Beta-lactamase AmpC, pseudomonas

AmpC_pseudomonas

4

IPR058165

58,165

Vancomycin/teicoplanin A-type resistance protein VanA-like

VanA-like

Family

482

false

This entry represents Vancomycin/teicoplanin A-type resistance protein VanA from Enterococcus faecium and similar proteins from actinomycetes and firmicutes. VanA is a D-Ala--D-Ala ligase of altered specificity which catalyses ester bond formation between D-Ala and various D-hydroxy acids. It produces a peptidoglycan w...

[ "GO:0008716", "GO:0046872" ]

[ "D-alanine-D-alanine ligase activity", "metal ion binding" ]

[ "molecular_function", "molecular_function" ]

2

[ "NCBIFAM" ]

[ "NF000206" ]

[ "D_ala_D_lac" ]

[ 482 ]

1

[]

0

[ "1e4e", "3se7" ]

2

[ "PUB00161013" ]

[ "1931965" ]

[ "Molecular basis for vancomycin resistance in Enterococcus faecium BM4147: biosynthesis of a depsipeptide peptidoglycan precursor by vancomycin resistance proteins VanH and VanA." ]

[ 1991 ]

1

[ "IPR005905" ]

[ "IPR058166" ]

1

0

[ "Bacteria", "unclassified sequences" ]

[ 478, 4 ]

2

[]

0

true

Family

Vancomycin/teicoplanin A-type resistance protein VanA-like

VanA-like

4

IPR058166

58,166

Vancomycin/teicoplanin A-type resistance protein VanA

VanA

Family

18

false

This entry represents Vancomycin/teicoplanin A-type resistance protein VanA from Enterococcus faecium and similar proteins from enterococcus species. VanA is a D-Ala--D-Ala ligase of altered specificity which catalyses ester bond formation between D-Ala and various D-hydroxy acids. It produces a peptidoglycan which doe...

[]

0

[ "NCBIFAM" ]

[ "NF012217" ]

[ "D_ala_D_lac_VanA" ]

[ 18 ]

1

[]

0

[ "1e4e" ]

1

[ "PUB00161013" ]

[ "1931965" ]

[ "Molecular basis for vancomycin resistance in Enterococcus faecium BM4147: biosynthesis of a depsipeptide peptidoglycan precursor by vancomycin resistance proteins VanH and VanA." ]

[ 1991 ]

1

[ "IPR058165" ]

[]

1

0

1

[ "Bacteria" ]

[ 18 ]

1

[]

0

true

Family

Vancomycin/teicoplanin A-type resistance protein VanA

VanA

8

IPR058169

58,169

Beta-lactamase PSE-1/CARB-3-like

PSE-1/CARB-3-like

Family

191

false

This entry represents Beta-lactamase PSE-1/CARB-3 from Pseudomonas aeruginosa and similar proteins from gammaproteobacteria. PSE-1 hydrolyses penicillin, ampicillin and carbenicillin but not other antibiotics including oxacillin, methicillin and cloxacillin [ ].

[ "GO:0008800" ]

[ "beta-lactamase activity" ]

[ "molecular_function" ]

1

[ "NCBIFAM" ]

[ "NF000481" ]

[ "carbeni_gen" ]

[ 191 ]

1

[ "EC" ]

[ "3.5.2.6" ]

[ "EC:3.5.2.6" ]

1

[ "1g68", "1g6a", "6izc", "6izd", "8j6y" ]

5

[ "PUB00161016" ]

[ "410783" ]

[ "Properties of the beta-lactamase specified by the Pseudomonas plasmid RPL11." ]

[ 1977 ]

1

[ "IPR000871" ]

[]

1

0

1

[ "Bacteria" ]

[ 191 ]

1

[]

0

true

Family

Beta-lactamase PSE-1/CARB-3-like

PSE-1/CARB-3-like

2

IPR058170

58,170

Beta-lactamase CblA, bacteroides

CblA_bacteroides

Family

34

false

This entry represents a group of beta-lactamases from bacteroides species, including beta-lactamase CblA from Bacteroides uniformis.

[ "GO:0008800" ]

[ "beta-lactamase activity" ]

[ "molecular_function" ]

1

[ "NCBIFAM" ]

[ "NF033098" ]

[ "bla_CblA" ]

[ 34 ]

1

[]

0

[]

0

[]

0

[ "IPR000871" ]

[]

1

0

1

[ "Bacteria", "uncultured organism" ]

[ 30, 4 ]

2

[]

0

true

Family

Beta-lactamase CblA, bacteroides

CblA_bacteroides

7

IPR058171

58,171

Beta-lactamase CfxA

CfxA

Family

165

false

This entry represents a group of beta-lactamases from bacteroidales, including CfxA from Phocaeicola vulgatus, which can hydrolyse cephalosporins, penicillins and also cefoxitin.

[ "GO:0008800" ]

[ "beta-lactamase activity" ]

[ "molecular_function" ]

1

[ "NCBIFAM" ]

[ "NF033100" ]

[ "bla_CfxA" ]

[ 165 ]

1

[]

0

[]

0

[]

0

[ "IPR000871" ]

[]

1

0

1

[ "Bacteria", "uncultured organism" ]

[ 164, 1 ]

2

[]

0

true

Family

Beta-lactamase CfxA

CfxA

8

IPR058172

58,172

HLGFF-containing, Neisseriales

HLGFF_Neisseriales

Family

118

false

This entry represents uncharacterised bacterial proteins from Neisseriales. These proteins contain an HLGFF motif with a β-barrel-like fold.

[]

0

[ "NCBIFAM", "PFAM" ]

[ "NF047841", "PF28291" ]

[ "HLGFF_fam", "HLGFF_Neisseriales" ]

[ 117, 118 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria" ]

[ 118 ]

1

[]

0

true

Family

HLGFF-containing, Neisseriales

HLGFF_Neisseriales

7