LiteFold/InterPro · Datasets at Hugging Face

IPR057948

57,948

E3 ubiquitin-protein ligase TRIP12-like, TPR repeats

TPR_TRIP12_N

Domain

7,393

false

This is a region of tetratricopeptide (TPR)-like repeats found at the N-terminal end of human E3 ubiquitin-protein ligase TRIP12 and similar eukaryotic proteins, including Ufd4 from budding yeasts and UPL3/4 from Arabidopsis. TRIP12 is involved in the ubiquitin fusion degradation pathway and regulation of DNA repair , ...

[]

0

[ "PFAM" ]

[ "PF25579" ]

[ "TPR_TRIP12_N" ]

[ 7393 ]

1

[ "EC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "2.3.2.26", "PWY-7511", "R-BTA-983168", "R-DRE-983168", "R-HSA-983168", "R-MMU-983168", "R-RNO-983168", "R-SCE-983168", "R-SPO-983168" ]

[ "EC:2.3.2.26", "METACYC:PWY-7511", "REACTOME:R-BTA-983168", "REACTOME:R-DRE-983168", "REACTOME:R-HSA-983168", "REACTOME:R-MMU-983168", "REACTOME:R-RNO-983168", "REACTOME:R-SCE-983168", "REACTOME:R-SPO-983168" ]

9

[ "8j1p", "8j1r", "9gkm", "9gkn", "9ken" ]

5

[ "PUB00063976", "PUB00098566", "PUB00098567", "PUB00160704", "PUB00160705", "PUB00160706", "PUB00160707", "PUB00160867", "PUB00160868", "PUB00160869" ]

[ "23250448", "22884692", "19028681", "24503158", "25284001", "25599645", "29042532", "10224275", "14530964", "28251352" ]

[ "Crystal Structure of Rice Importin-α and Structural Basis of Its Interaction with Plant-Specific Nuclear Localization Signals.", "TRIP12 and UBR5 suppress spreading of chromatin ubiquitylation at damaged chromosomes.", "The HECT domain of TRIP12 ubiquitinates substrates of the ubiquitin fusion degradation path...

[ 2012, 2012, 2009, 2014, 2015, 2015, 2017, 1999, 2003, 2017 ]

10

[]

0

null

[ "Eukaryota" ]

[ 7393 ]

1

[ "Arabidopsis thaliana", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "...

[ 14, 19, 12, 13, 8, 4, 7, 9, 1, 1, 39 ]

11

true

Domain

E3 ubiquitin-protein ligase TRIP12-like, TPR repeats

TPR_TRIP12_N

5

IPR057949

57,949

TEX10-like, TPR repeats

TPR_TEX10

Domain

2,015

false

This is the C-terminal region of human Testis-expressed protein 10 (TEX10), which consists of tetratricopeptide (TPR)-like repeats. TEX10 functions as a component of the Five Friends of Methylated Chtop complex, which can only be recruited when Chtop is arginine-methylated leading to transactivation of ZNF148 target ge...

[]

0

[ "PFAM" ]

[ "PF25781" ]

[ "TPR_TEX10" ]

[ 2015 ]

1

[ "REACTOME", "REACTOME" ]

[ "R-HSA-6791226", "R-MMU-6791226" ]

[ "REACTOME:R-HSA-6791226", "REACTOME:R-MMU-6791226" ]

2

[ "8fl2", "8fl3", "8fl4", "9dum" ]

4

[ "PUB00078806", "PUB00087911" ]

[ "21326211", "22872859" ]

[ "The SUMO system controls nucleolar partitioning of a novel mammalian ribosome biogenesis complex.", "Five friends of methylated chromatin target of protein-arginine-methyltransferase[prmt]-1 (chtop), a complex linking arginine methylation to desumoylation." ]

[ 2011, 2012 ]

2

[]

0

null

[ "Eukaryota" ]

[ 2015 ]

1

[ "Arabidopsis thaliana", "Danio rerio", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 9, 2, 2, 1, 2, 3, 5 ]

7

true

Domain

TEX10-like, TPR repeats

TPR_TEX10

8

IPR057950

57,950

RIMB1/RIM3A-C-like, N-terminal domain

RIMB1/RIM3A-C-like_N

Domain

1,630

false

This domain is found at the N-terminal end of human Peripheral-type benzodiazepine receptor-associated protein 1 (RIMB1), RIMS-binding protein 3A-C (RIM3A-C) and similar proteins mainly found in animals. RIMB1 is required for synaptic transmission regulation [ ] and probably controls the recruitment of voltage-gated ca...

[]

0

[ "PFAM" ]

[ "PF25566" ]

[ "RIMB1_N" ]

[ 1630 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-181429", "R-HSA-181430", "R-HSA-196108", "R-HSA-210500", "R-HSA-212676", "R-HSA-264642", "R-MMU-181429", "R-MMU-181430", "R-MMU-196108", "R-MMU-210500", "R-MMU-212676", "R-MMU-264642", "R-RNO-181429", "R-RNO-181430", "R-RNO-196108", "R-RNO-210500", "R-RNO-212676", "R-RNO-264...

[ "REACTOME:R-HSA-181429", "REACTOME:R-HSA-181430", "REACTOME:R-HSA-196108", "REACTOME:R-HSA-210500", "REACTOME:R-HSA-212676", "REACTOME:R-HSA-264642", "REACTOME:R-MMU-181429", "REACTOME:R-MMU-181430", "REACTOME:R-MMU-196108", "REACTOME:R-MMU-210500", "REACTOME:R-MMU-212676", "REACTOME:R-MMU-264...

18

[]

0

[ "PUB00085469", "PUB00085470", "PUB00085471", "PUB00085472", "PUB00085473", "PUB00160870", "PUB00160871" ]

[ "11988172", "17855024", "10748113", "19091768", "22174254", "28003339", "33539324" ]

[ "RIM binding proteins (RBPs) couple Rab3-interacting molecules (RIMs) to voltage-gated Ca(2+) channels.", "Structure and evolution of RIM-BP genes: identification of a novel family member.", "The RIM/NIM family of neuronal C2 domain proteins. Interactions with Rab3 and a new class of Src homology 3 domain prote...

[ 2002, 2007, 2000, 2009, 2011, 2017, 2021 ]

7

[]

0

null

[ "Opisthokonta" ]

[ 1630 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 40, 16, 3, 7 ]

4

true

Domain

RIMB1/RIM3A-C-like, N-terminal domain

RIMB1/RIM3A-C-like_N

6

IPR057952

57,952

Rv2743c-like

Family

1,104

false

This entry represents Putative envelope-preserving system protein Rv2743c from Mycobacterium tuberculosis and similar proteins from actinomycetes. Rv2743c plays a crucial role in maintaining envelope integrity and tolerance to surface stress [ , ]. It is part of a four-gene operon that includes clgR, pspA, rv2743c, and...

[]

0

[ "NCBIFAM", "PFAM" ]

[ "NF047839", "PF25587" ]

[ "PspM_Rv2743c", "Rv2743c" ]

[ 1074, 1102 ]

2

[]

0

[]

0

[ "PUB00095086", "PUB00154694", "PUB00158885", "PUB00160672" ]

[ "25899163", "25422323", "38809013", "27865622" ]

[ "The Psp system of Mycobacterium tuberculosis integrates envelope stress-sensing and envelope-preserving functions.", "The Mycobacterium tuberculosis Clp gene regulator is required for in vitro reactivation from hypoxia-induced dormancy.", "The phage shock protein (PSP) envelope stress response: discovery of no...

[ 2015, 2015, 2024, 2017 ]

4

[]

0

null

[ "Actinomycetes", "Halorussus gelatinilyticus", "freshwater metagenome" ]

[ 1101, 1, 2 ]

3

[]

0

true

Family

Rv2743c-like

7

IPR057953

57,953

Suppressor APC domain-containing protein 2, N-terminal EF-hand-like domain

SAPC2_N

Domain

1,224

false

This entry represents the EF-hand-like fold found at the N-terminal end of suppressor APC domain-containing protein 2 (SAPC2) and related proteins in animals [ ]. In humans, SAPC2 plays a role in planar mitotic spindle orientation. It is also involved in positive regulation of cell proliferation and tumour cell growth ...

[]

0

[ "PFAM" ]

[ "PF25825" ]

[ "SAPC2_N" ]

[ 1224 ]

1

[]

0

[]

0

[ "PUB00061903", "PUB00147885", "PUB00160674", "PUB00160675", "PUB00160676" ]

[ "17525738", "26766442", "23576022", "23704824", "25313560" ]

[ "Identification and characterization of a novel p42.3 gene as tumor-specific and mitosis phase-dependent expression in gastric cancer.", "SAPCD2 Controls Spindle Orientation and Asymmetric Divisions by Negatively Regulating the Gαi-LGN-NuMA Ternary Complex.", "p42.3: a promising biomarker for the progression an...

[ 2007, 2016, 2013, 2013, 2014 ]

5

[]

0

null

[ "Eukaryota" ]

[ 1224 ]

1

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 1, 1, 1, 3 ]

5

true

Domain

Suppressor APC domain-containing protein 2, N-terminal EF-hand-like domain

SAPC2_N

3

IPR057954

57,954

Tubulin--tyrosine ligase-like protein 12, SET-like domain

SET_TTL12

Domain

2,709

false

This entry represents the SET-like domain found in Tubulin--tyrosine ligase-like protein 12 (TTL12) and related proteins in eukaryotes. Tubulin tyrosine ligase-like 12 (TTLL2) is a member of the tubulin tyrosine ligase (TTL) group, although its precise function remains unclear. TTLL2 contains both SET-like and TTL-like...

[]

0

[ "PFAM" ]

[ "PF25556" ]

[ "SET_TTL" ]

[ 2709 ]

1

[ "REACTOME", "REACTOME" ]

[ "R-HSA-8955332", "R-MMU-8955332" ]

[ "REACTOME:R-HSA-8955332", "REACTOME:R-MMU-8955332" ]

2

[]

0

[ "PUB00070170", "PUB00160678" ]

[ "23251473", "20162578" ]

[ "Tubulin tyrosine ligase like 12, a TTLL family member with SET- and TTL-like domains and roles in histone and tubulin modifications and mitosis.", "Tubulin tyrosine ligase like 12 links to prostate cancer through tubulin posttranslational modification and chromosome ploidy." ]

[ 2012, 2010 ]

2

[]

0

null

[ "Eukaryota" ]

[ 2709 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 5, 1, 1, 1, 2, 1, 5, 2, 8 ]

9

true

Domain

Tubulin--tyrosine ligase-like protein 12, SET-like domain

SET_TTL12

1

IPR057955

57,955

SF0329-like

Family

790

false

This family includes SF0329 ( ) from Shigella flexneri and similar bacterial sequences. Full length homologues of SF0329 are found in hundreds of bacterial species. The function of these proteins is still unknown.

[]

0

[ "NCBIFAM", "PFAM" ]

[ "NF049912", "PF25753" ]

[ "SF0329_fam", "SF0329" ]

[ 750, 790 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Ricinus communis", "metagenomes" ]

[ 779, 1, 10 ]

3

[]

0

true

Family

SF0329-like

6

IPR057956

57,956

Major coat protein VP4

SFV1_VP4

Family

3

false

This entry represents one of the two major coat proteins (VP4) of Sulfolobus filamentous virus 1 (SFV1), a membrane-enveloped filamentous virus that infects the hyperthermophilic acidophile Sulfolobus shibatae. VP4 forms a heterodimer with VP5 and wraps around A-form DNA. Despite having no detectable sequence similarit...

[]

0

[ "PFAM" ]

[ "PF25647" ]

[ "SFV1_VP4" ]

[ 3 ]

1

[]

0

[ "6d5f" ]

1

[ "PUB00160679" ]

[ "30135568" ]

[ "Structural conservation in a membrane-enveloped filamentous virus infecting a hyperthermophilic acidophile." ]

[ 2018 ]

1

[]

0

null

[ "Alphalipothrixvirus" ]

[ 3 ]

1

[]

0

true

Family

Major coat protein VP4

SFV1_VP4

6

IPR057957

57,957

Major coat protein VP5

SFV1_VP5

Family

3

false

This entry represents one of the two major coat proteins (VP5) of Sulfolobus filamentous virus 1 (SFV1), a membrane-enveloped filamentous virus that infects the hyperthermophilic acidophile Sulfolobus shibatae. VP5 forms a heterodimer with VP4 and wraps around A-form DNA. Compared to VP4, VP5 has an insertion containin...

[]

0

[ "PFAM" ]

[ "PF25648" ]

[ "SFV1_VP5" ]

[ 3 ]

1

[]

0

[ "6d5f" ]

1

[ "PUB00160679" ]

[ "30135568" ]

[ "Structural conservation in a membrane-enveloped filamentous virus infecting a hyperthermophilic acidophile." ]

[ 2018 ]

1

[]

0

null

[ "Alphalipothrixvirus" ]

[ 3 ]

1

[]

0

true

Family

Major coat protein VP5

SFV1_VP5

8

IPR057958

57,958

SH3b_P2 domain

SH3b_P2_dom

Domain

144

false

This entry represents a bacterial SH3 domain. This domain is typically present in peptidoglycan-degrading enzymes from bacteriophages as a cell wall-binding domain. It is closely related to ( ).

[]

0

[ "PFAM" ]

[ "PF25606" ]

[ "SH3b_P2" ]

[ 144 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Acyrthosiphon pisum", "Bacteria", "Viruses" ]

[ 1, 95, 48 ]

3

[]

0

true

Domain

SH3b_P2 domain

SH3b_P2_dom

2

IPR057959

57,959

Shotokuvirus capsid protein

Shotoku_capsid

Family

27

false

This entry represents the capsid proteins from Shotokuviruses that are responsible for forming the icosahedral capsid of virions. Members of this family have the ability to self-assemble, which is a critical function in the construction of the protective shell that encases the viral genome. This structural role is esse...

[]

0

[ "PFAM" ]

[ "PF25628" ]

[ "Shotoku_capsid" ]

[ 27 ]

1

[]

0

[ "7ns0", "9s3s" ]

2

[]

0

[]

0

null

[ "Bacillariophycidae", "Viruses" ]

[ 6, 21 ]

2

[]

0

true

Family

Shotokuvirus capsid protein

Shotoku_capsid

1

IPR057961

57,961

Gp41

Family

7

false

This entry represents a family of proteins related to gene 41 protein from Bacillus phage SP01. Its specific function remains unknown. Members of this family are found in bacteriophages that infect Bacillus species.

[]

0

[ "PFAM" ]

[ "PF25749" ]

[ "SPO1_gp41" ]

[ 7 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Caudoviricetes" ]

[ 7 ]

1

[]

0

true

Family

Gp41

2

IPR057962

57,962

SPT23/MGA2-like, DNA-binding domain

SPT23_MGA2_DBD

Domain

1,992

false

This entry represents the DNA-binding domain found in yeast SPT23 and MGA2 transcription factors. The specific function of this DNA-binding domain remains to be fully characterised [ ]. SPT23 and MGA2 are involved in the regulation of OLE1 gene expression, which encodes a fatty acid desaturase essential for unsaturated...

[]

0

[ "PFAM" ]

[ "PF25603" ]

[ "SPT23_MGA2_DBD" ]

[ 1992 ]

1

[]

0

[]

0

[ "PUB00160680", "PUB00160905" ]

[ "11063674", "9927444" ]

[ "MGA2 and SPT23 are modifiers of transcriptional silencing in yeast.", "MGA2 or SPT23 is required for transcription of the delta9 fatty acid desaturase gene, OLE1, and nuclear membrane integrity in Saccharomyces cerevisiae." ]

[ 2000, 1999 ]

2

[]

0

null

[ "Eukaryota" ]

[ 1992 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 2, 2, 1 ]

3

true

Domain

SPT23/MGA2-like, DNA-binding domain

SPT23_MGA2_DBD

1

IPR057963

57,963

Capsid protein VP10

SPV1_VP10

Family

2

false

This entry represents the VP10 capsid protein found in Sulfolobus polyhedral virus 1 (SPV1), a virus that infects hyperthermophilic acidophilic archaea. VP10 forms pentamers located at the 5-fold axes of the icosahedral virion. Despite having low sequence identity (~15%) with the major capsid protein VP4, VP10 shares a...

[]

0

[ "PFAM" ]

[ "PF25635" ]

[ "SPV1_VP10" ]

[ 2 ]

1

[]

0

[ "6oj0" ]

1

[ "PUB00160681" ]

[ "31636205" ]

[ "A packing for A-form DNA in an icosahedral virus." ]

[ 2019 ]

1

[]

0

null

[ "Alphaportoglobovirus" ]

[ 2 ]

1

[]

0

true

Family

Capsid protein VP10

SPV1_VP10

5

IPR057964

57,964

Major capsid protein VP4

SPV1_VP4

Family

2

false

This entry represents the major capsid protein VP4 from Sulfolobus polyhedral virus 1 (SPV1), which infects hyperthermophilic acidophilic archaea. VP4 is the primary component of the icosahedral capsid of SPV1, forming hexamers that assemble into a T=43 surface lattice. The protein adopts a variation of the jelly-roll ...

[]

0

[ "PFAM" ]

[ "PF25646" ]

[ "SPV1_VP4" ]

[ 2 ]

1

[]

0

[ "6oj0" ]

1

[ "PUB00160681" ]

[ "31636205" ]

[ "A packing for A-form DNA in an icosahedral virus." ]

[ 2019 ]

1

[]

0

null

[ "Alphaportoglobovirus" ]

[ 2 ]

1

[]

0

true

Family

Major capsid protein VP4

SPV1_VP4

5

IPR057966

57,966

Capsid assembly scaffolding protein, T4-phage

T4_SCAF

Family

625

false

This entry represents Capsid assembly scaffolding protein from Enterobacteria phage T4 (SCAF) and similar sequences mainly found in tailed bacteriophages. Members of this protein family are crucial for the assembly of icosahedral procapsids in bacteriophages. These proteins coassemble with capsid proteins to form the p...

[]

0

[ "PFAM" ]

[ "PF25623" ]

[ "T4_CASP" ]

[ 625 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Pseudomonadati", "Viruses", "metagenomes" ]

[ 4, 2, 590, 29 ]

4

[]

0

true

Family

Capsid assembly scaffolding protein, T4-phage

T4_SCAF

6

IPR057967

57,967

Tape measure protein-like

T4_TMP

Family

299

false

This entry represents bacteriophage tape measure proteins (TMP) that serve as molecular rulers determining the length of phage tails [ ]. During tail assembly, the TMP acts as a template for tail tube polymerisation, with the protein being incorporated in an initially unfolded form. As the tail tube forms, the TMP exte...

[]

0

[ "PFAM" ]

[ "PF25671" ]

[ "T4_Tape_measure" ]

[ 299 ]

1

[]

0

[ "9f4b" ]

1

[ "PUB00160873" ]

[ "8122363" ]

[ "Tail length determination in bacteriophage T4." ]

[ 1994 ]

1

[]

0

null

[ "Bacteria", "Viruses" ]

[ 3, 296 ]

2

[]

0

true

Family

Tape measure protein-like

T4_TMP

4

IPR057968

57,968

Phage T4 Y03C-like

T4_Y03C-like

Family

177

false

This entry represents a family of small uncharacterised proteins found in bacteriophage T4, including the 10.3 kDa protein encoded in the Gp46-Gp47 intergenic region of T4 phage (Y03C). The function of this protein family remains unknown.

[]

0

[ "PFAM" ]

[ "PF25721" ]

[ "T4_Y03C" ]

[ 177 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Viruses" ]

[ 177 ]

1

[]

0

true

Family

Phage T4 Y03C-like

T4_Y03C-like

2

IPR057969

57,969

Bacteriophage T4 Y13H-like

T4_Y13H-like

Family

145

false

This entry represents the uncharacterised Y13H (cd.5) protein found in Enterobacteria phage T4. The protein is encoded in the cd-pseT intergenic region of the phage genome. The function of this small 8.7 kDa protein remains unknown. It may play a role in phage replication or host interaction.

[]

0

[ "PFAM" ]

[ "PF25744" ]

[ "T4_Y13H" ]

[ 145 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Viruses", "marine sediment metagenome" ]

[ 144, 1 ]

2

[]

0

true

Family

Bacteriophage T4 Y13H-like

T4_Y13H-like

4

IPR057970

57,970

Tail completion protein p143

T5_p143

Family

233

false

This entry represents the tail completion protein p143 found in bacteriophage T5. Unlike typical tail completion proteins that are located at the head-tail joining region, p143 is found at the base of only one BHP pb3 monomer in the T5 tail tip. This protein appears to have a role in tail stability [ ] and may detach d...

[]

0

[ "PFAM" ]

[ "PF25747" ]

[ "T5_p143" ]

[ 233 ]

1

[]

0

[]

0

[ "PUB00155631" ]

[ "36961893" ]

[ "Structural basis of bacteriophage T5 infection trigger and E. coli cell wall perforation." ]

[ 2023 ]

1

[]

0

null

[ "Viruses" ]

[ 233 ]

1

[]

0

true

Family

Tail completion protein p143

T5_p143

4

IPR057971

57,971

Pleckstrin homology domain-containing family A member 4-7, TBCA domain

PKHA4-7_TBCA

Domain

9,335

false

This entry represents the tubulin chaperone cofactor A (TBCA) domain in Pleckstrin homology (PH) domain-containing proteins, mostly found in eukaryotes. The TBCA fold displays three α-helices forming an antiparallel bundle. Human TBCA functions as a molecular chaperone for beta-tubulin [ ]. PH domain-containing protein...

[]

0

[ "PFAM" ]

[ "PF25541" ]

[ "TBCA_PH" ]

[ 9335 ]

1

[ "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-1660499", "R-MMU-1660499", "R-RNO-1660499" ]

[ "REACTOME:R-HSA-1660499", "REACTOME:R-MMU-1660499", "REACTOME:R-RNO-1660499" ]

3

[]

0

[ "PUB00014130", "PUB00025558" ]

[ "14594214", "12054808" ]

[ "Membrane targeting by pleckstrin homology domains.", "Three-dimensional structure of human tubulin chaperone cofactor A." ]

[ 2004, 2002 ]

2

[]

0

null

[ "Bacteria", "Eukaryota" ]

[ 3, 9332 ]

2

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 204, 7, 24, 27, 33 ]

5

true

Domain

Pleckstrin homology domain-containing family A member 4-7, TBCA domain

PKHA4-7_TBCA

4

IPR057973

57,973

Transmembrane protein 218, N-terminal domain

TMEM218_N

Domain

592

false

This domain is found at the N-terminal end of human Transmembrane protein 218 (TMEM218), which may be involved in ciliary biogenesis or function [ ].

[]

0

[ "PFAM" ]

[ "PF25810" ]

[ "TMEM218_N" ]

[ 592 ]

1

[]

0

[]

0

[ "PUB00160874" ]

[ "25161209" ]

[ "Nephronophthisis and retinal degeneration in tmem218-/- mice: a novel mouse model for Senior-Loken syndrome?" ]

[ 2015 ]

1

[]

0

null

[ "Opisthokonta" ]

[ 592 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 5, 5, 1, 2 ]

4

true

Domain

Transmembrane protein 218, N-terminal domain

TMEM218_N

3

IPR057974

57,974

NUA/TPR/MLP1-2-like domain

NUA/TPR/MLP1-2-like_dom

Domain

4,798

false

This domain is found in human Nucleoprotein TPR, Nuclear-pore anchor from Arabidopsis thaliana (NUA), yeast Protein MLP1/2 and similar eukaryotic proteins. This domain is often found associated with and is predicted to adopt an all-α structure. TPR is a component of the nuclear pore complex (NPC), a complex required fo...

[]

0

[ "PFAM" ]

[ "PF25785" ]

[ "TPR" ]

[ 4798 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-DME-159227", "R-DME-159230", "R-DME-159231", "R-DME-159236", "R-DME-170822", "R-DME-3108214", "R-DME-3301854", "R-DME-4085377", "R-DME-4551638", "R-DME-4615885", "R-DME-5578749", "R-HSA-1169408", "R-HSA-159227", "R-HSA-159230", "R-HSA-159231", "R-HSA-159236", "R-HSA-165054", "R-...

[ "REACTOME:R-DME-159227", "REACTOME:R-DME-159230", "REACTOME:R-DME-159231", "REACTOME:R-DME-159236", "REACTOME:R-DME-170822", "REACTOME:R-DME-3108214", "REACTOME:R-DME-3301854", "REACTOME:R-DME-4085377", "REACTOME:R-DME-4551638", "REACTOME:R-DME-4615885", "REACTOME:R-DME-5578749", "REACTOME:R-H...

85

[]

0

[ "PUB00087394", "PUB00160875", "PUB00160876", "PUB00160877" ]

[ "22253824", "10638763", "17535820", "19704557" ]

[ "Localization of nucleoporin Tpr to the nuclear pore complex is essential for Tpr mediated regulation of the export of unspliced RNA.", "Nuclear pore complexes in the organization of silent telomeric chromatin.", "The nuclear pore protein AtTPR is required for RNA homeostasis, flowering time, and auxin signalin...

[ 2012, 2000, 2007, 2007 ]

4

[]

0

null

[ "Eukaryota" ]

[ 4798 ]

1

[ "Arabidopsis thaliana", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "...

[ 4, 9, 3, 4, 7, 1, 1, 4, 2, 1, 32 ]

11

true

Domain

NUA/TPR/MLP1-2-like domain

NUA/TPR/MLP1-2-like_dom

6

IPR057975

57,975

Anaphase-promoting complex subunit 2, TPR repeats

TPR_ANAPC2

Domain

4,458

false

This is a region of tetratricopeptide (TPR)-like repeats found in human Anaphase-promoting complex subunit 2 (ANAPC2) and similar eukaryotic sequences. ANAPC2 is part of the catalytic component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression thro...

[]

0

[ "PFAM" ]

[ "PF25773" ]

[ "TPR_ANAPC2" ]

[ 4458 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-CEL-983168", "R-DDI-141430", "R-DDI-174048", "R-DDI-174084", "R-DDI-174154", "R-DDI-174178", "R-DDI-174184", "R-DDI-176407", "R-DDI-176408", "R-DDI-176409", "R-DDI-176412", "R-DDI-179409", "R-DDI-2467813", "R-DDI-2559582", "R-DDI-69017", "R-DDI-983168", "R-HSA-141430", "R-HSA-17...

[ "REACTOME:R-CEL-983168", "REACTOME:R-DDI-141430", "REACTOME:R-DDI-174048", "REACTOME:R-DDI-174084", "REACTOME:R-DDI-174154", "REACTOME:R-DDI-174178", "REACTOME:R-DDI-174184", "REACTOME:R-DDI-176407", "REACTOME:R-DDI-176408", "REACTOME:R-DDI-176409", "REACTOME:R-DDI-176412", "REACTOME:R-DDI-179...

52

[ "4ui9", "5a31", "5g04", "5g05", "5khr", "5khu", "5l9t", "5l9u", "5lcw", "6q6g", "6q6h", "6tlj", "6tm5", "6tnt", "8a3t", "8a5y", "8a61", "8pkp", "8tar", "8tau", "9gaw", "9n9r", "9n9s" ]

23

[ "PUB00059221", "PUB00091489", "PUB00137338", "PUB00152679", "PUB00160689" ]

[ "18485873", "26083744", "11739784", "27522463", "37735619" ]

[ "Mechanism of ubiquitin-chain formation by the human anaphase-promoting complex.", "Atomic structure of the APC/C and its mechanism of protein ubiquitination.", "APC2 Cullin protein and APC11 RING protein comprise the minimal ubiquitin ligase module of the anaphase-promoting complex.", "Cryo-EM of Mitotic Che...

[ 2008, 2015, 2001, 2016, 2023 ]

5

[]

0

null

[ "Eukaryota" ]

[ 4458 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 3, 1, 1, 2, 2, 4, 1, 4, 3, 1, 1, 12 ]

12

true

Domain

Anaphase-promoting complex subunit 2, TPR repeats

TPR_ANAPC2

1

IPR057977

57,977

DENND3-like, TPR repeats

TPR_DENND3

Domain

1,547

false

This is a region of tetratricopeptide (TPR)-like repeats found in human DENN domain-containing protein 3 (DENND3) and similar proteins from vertebrates. DENND3 is a guanine nucleotide exchange factor (GEF) that promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB12 into its active GTP-bound form [ ].

[]

0

[ "PFAM" ]

[ "PF25570" ]

[ "TPR_DENND3" ]

[ 1547 ]

1

[ "REACTOME", "REACTOME" ]

[ "R-HSA-8876198", "R-MMU-8876198" ]

[ "REACTOME:R-HSA-8876198", "REACTOME:R-MMU-8876198" ]

2

[]

0

[ "PUB00073236" ]

[ "20937701" ]

[ "Family-wide characterization of the DENN domain Rab GDP-GTP exchange factors." ]

[ 2010 ]

1

[]

0

null

[ "Eukaryota" ]

[ 1547 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 11, 3, 2, 3 ]

4

true

Domain

DENND3-like, TPR repeats

TPR_DENND3

2

IPR057978

57,978

Dynein axonemal assembly factor 5, TPR repeats

TPR_DAAF5

Domain

2,924

false

This is a region of tetratricopeptide (TPR)-like repeats found towards the N-terminal end of human Dynein axonemal assembly factor 5 (DNAAF5) and similar eukaryotic proteins. DAAF5 is a cytoplasmic protein involved in the delivery of the dynein machinery to the motile cilium. It is required for the assembly of the axon...

[]

0

[ "PFAM" ]

[ "PF25757" ]

[ "TPR_DNAAF5" ]

[ 2924 ]

1

[]

0

[]

0

[ "PUB00006180", "PUB00030197", "PUB00030257", "PUB00031678", "PUB00031809", "PUB00154951", "PUB00154952" ]

[ "9989501", "10353245", "10353244", "15537541", "14645851", "23040496", "25232951" ]

[ "The structure of the protein phosphatase 2A PR65/A subunit reveals the conformation of its 15 tandemly repeated HEAT motifs.", "Structure of the nuclear transport complex karyopherin-beta2-Ran x GppNHp.", "Structure of importin-beta bound to the IBB domain of importin-alpha.", "Structure of the Cand1-Cul1-Ro...

[ 1999, 1999, 1999, 2004, 2003, 2012, 2014 ]

7

[]

0

null

[ "Eukaryota" ]

[ 2924 ]

1

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 1, 4, 2, 5 ]

5

true

Domain

Dynein axonemal assembly factor 5, TPR repeats

TPR_DAAF5

9

IPR057979

57,979

IFT121-like, TPR repeats

TPR_IFT121

Domain

2,278

false

This region of tetratricopeptide (TPR)-like repeats is found towards the C-terminal end of IFT121. IFT121 (also known as WDR35) is a component of the IFT complex A (IFT-A), which is required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors that is involved in ciliogenesis and ciliary...

[]

0

[ "PFAM" ]

[ "PF25768" ]

[ "TPR_IFT121" ]

[ 2278 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-5610787", "R-HSA-5620924", "R-MMU-5610787", "R-MMU-5620924", "R-RNO-5610787", "R-RNO-5620924" ]

[ "REACTOME:R-HSA-5610787", "REACTOME:R-HSA-5620924", "REACTOME:R-MMU-5610787", "REACTOME:R-MMU-5620924", "REACTOME:R-RNO-5610787", "REACTOME:R-RNO-5620924" ]

6

[ "8bbe", "8bbg", "8bda", "8f5o", "8f5p", "8fgw", "8fh3", "8hmc", "8hmd", "8ruy" ]

10

[ "PUB00083315", "PUB00089704", "PUB00101515", "PUB00101516", "PUB00155528", "PUB00155869", "PUB00158865", "PUB00160195" ]

[ "21473986", "20889716", "28400947", "29220510", "36462505", "36593313", "36775821", "36563665" ]

[ "Human and mouse mutations in WDR35 cause short-rib polydactyly syndromes due to abnormal ciliogenesis.", "TULP3 bridges the IFT-A complex and membrane phosphoinositides to promote trafficking of G protein-coupled receptors into primary cilia.", "Mutations in IFT-A satellite core component genes IFT43 an...

[ 2011, 2010, 2017, 2018, 2022, 2023, 2023, 2022 ]

8

[]

0

null

[ "Eukaryota" ]

[ 2278 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 2, 1, 2, 1, 3 ]

6

true

Domain

IFT121-like, TPR repeats

TPR_IFT121

7

IPR057980

57,980

Integrator complex subunit 8, TPR repeats

TPR_INTS8_C

Domain

2,346

false

This is a region of tetratricopeptide (TPR)-like repeats found towards the C-terminal end of human Integrator complex subunit 8 (INTS8) and similar animal sequences. Integrator complex subunit 8 (INTS8) is a component of the multiprotein complex Integrator, which is responsible for the endonucleolytic cleavage in the s...

[]

0

[ "PFAM" ]

[ "PF25756" ]

[ "TPR_INTS8" ]

[ 2346 ]

1

[ "REACTOME", "REACTOME", "REACTOME" ]

[ "R-DME-6807505", "R-HSA-6807505", "R-MMU-6807505" ]

[ "REACTOME:R-DME-6807505", "REACTOME:R-HSA-6807505", "REACTOME:R-MMU-6807505" ]

3

[ "7cun", "7pks", "7ycx", "8rbx", "8rbz", "8rc4", "8yjb", "9eof", "9ep4", "9vd9" ]

10

[ "PUB00045283", "PUB00060148", "PUB00060149", "PUB00088538", "PUB00152015", "PUB00155682", "PUB00160694", "PUB00160695", "PUB00160880", "PUB00160881" ]

[ "16239144", "22250197", "22252320", "28542170", "33243860", "38570683", "35258937", "38823386", "34004147", "37080207" ]

[ "Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II.", "The integrator complex is required for integrity of Cajal bodies.", "snRNA 3' end formation requires heterodimeric association of integrator subunits.", "Human mutations in inte...

[ 2005, 2012, 2012, 2017, 2020, 2024, 2022, 2024, 2021, 2023 ]

10

[]

0

null

[ "Eukaryota" ]

[ 2346 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 5, 1, 6, 3, 4 ]

6

true

Domain

Integrator complex subunit 8, TPR repeats

TPR_INTS8_C

5

IPR057981

57,981

LAA1-like, C-terminal TPR repeats

TPR_LAA1-like_C

Domain

2,022

false

This is a region of tetratricopeptide (TPR)-like repeats found at the C-terminal end of AP-1 accessory protein LAA1 from Saccharomyces cerevisiae and similar sequences mainly found in fungi. LAA1 is involved in localisation of clathrin adapter protein complex-1 (AP-1) and subsequent AP-1-mediated clathrin-coated vesicl...

[]

0

[ "PFAM" ]

[ "PF25808" ]

[ "TPR_LAA1_C" ]

[ 2022 ]

1

[]

0

[]

0

[ "PUB00090529", "PUB00155153" ]

[ "19243310", "30523155" ]

[ "Identification of a conserved F-box protein 6 interactor essential for endocytosis and cytokinesis in fission yeast.", "Adaptor protein complex-1 (AP-1) is recruited by the HEATR5 protein Laa1 and its co-factor Laa2 in yeast." ]

[ 2009, 2019 ]

2

[]

0

null

[ "Eukaryota" ]

[ 2022 ]

1

[ "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 1, 1, 1, 1 ]

5

true

Domain

LAA1-like, C-terminal TPR repeats

TPR_LAA1-like_C

2

IPR057982

57,982

NAA35-like, TPR repeats

TPR_NAA35

Domain

4,868

false

This is a region of tetratricopeptide (TPR)-like repeats found at the C-terminal end of human N-alpha-acetyltransferase 35, NatC auxiliary subunit (NAA35) and similar sequences. In budding yeasts, NatC N(alpha)-terminal acetyltransferases contain Mak10, Mak31 and Mak3 subunits. All three subunits are associated with ea...

[]

0

[ "PFAM" ]

[ "PF25789" ]

[ "TPR_NAA35" ]

[ 4868 ]

1

[ "REACTOME" ]

[ "R-HSA-6811440" ]

[ "REACTOME:R-HSA-6811440" ]

1

[ "6yga", "6ygb", "6ygc", "6ygd", "7l1k", "7mx2", "7rb3" ]

7

[ "PUB00009844", "PUB00091098", "PUB00155198", "PUB00160698", "PUB00160699", "PUB00160700" ]

[ "11274203", "19398576", "37891180", "36638802", "33139728", "34019809" ]

[ "NatC Nalpha-terminal acetyltransferase of yeast contains three subunits, Mak3p, Mak10p, and Mak31p.", "Knockdown of human N alpha-terminal acetyltransferase complex C leads to p53-dependent apoptosis and aberrant human Arl8b localization.", "N-terminal acetylation shields proteins from degradation and promotes...

[ 2001, 2009, 2023, 2023, 2020, 2021 ]

6

[]

0

null

[ "Eukaryota" ]

[ 4868 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 13, 1, 1, 2, 2, 4, 1, 3, 6, 1, 1, 11 ]

12

true

Domain

NAA35-like, TPR repeats

TPR_NAA35

1

IPR057983

57,983

NAA35-like, N-terminal

NAA35-like_N

Domain

4,708

false

This entry represents the N-terminal region of human N-alpha-acetyltransferase 35, NatC auxiliary subunit (NAA35) and similar sequences. In budding yeasts, NatC N(alpha)-terminal acetyltransferases contain Mak10, Mak31 and Mak3 subunits. All three subunits are associated with each other to form the active complex [ ]. ...

[]

0

[ "PFAM" ]

[ "PF04112" ]

[ "Mak10" ]

[ 4708 ]

1

[ "REACTOME" ]

[ "R-HSA-6811440" ]

[ "REACTOME:R-HSA-6811440" ]

1

[ "6yga", "6ygb", "6ygc", "6ygd", "7l1k", "7mx2", "7rb3" ]

7

[ "PUB00009844", "PUB00091098", "PUB00155198" ]

[ "11274203", "19398576", "37891180" ]

[ "NatC Nalpha-terminal acetyltransferase of yeast contains three subunits, Mak3p, Mak10p, and Mak31p.", "Knockdown of human N alpha-terminal acetyltransferase complex C leads to p53-dependent apoptosis and aberrant human Arl8b localization.", "N-terminal acetylation shields proteins from degradation and promotes...

[ 2001, 2009, 2023 ]

3

[]

0

null

[ "Eukaryota" ]

[ 4708 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 11, 1, 1, 2, 2, 5, 1, 3, 7, 1, 1, 10 ]

12

true

Domain

NAA35-like, N-terminal

NAA35-like_N

1

IPR057984

57,984

PATROL1-like, C-terminal

PATROL1_C

Domain

4,116

false

This region is found towards the C-terminal end of Protein unc-13 homolog from Arabidopsis thaliana (PATROL1), which is essential for stomatal opening in response to low concentration of carbon dioxide and light [ ]. PATROL1 controls the tethering of proton ATPase AHA1 to the plasma membrane and is essential for stomat...

[]

0

[ "PFAM" ]

[ "PF25761" ]

[ "TPR_PATROL1" ]

[ 4116 ]

1

[]

0

[]

0

[ "PUB00088405" ]

[ "23896897" ]

[ "A Munc13-like protein in Arabidopsis mediates H+-ATPase translocation that is essential for stomatal responses." ]

[ 2013 ]

1

[]

0

null

[ "Eukaryota" ]

[ 4116 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 39, 33, 49 ]

3

true

Domain

PATROL1-like, C-terminal

PATROL1_C

7

IPR057985

57,985

26S proteasome non-ATPase regulatory subunit 3, N-terminal TPR repeats

TPR_PSMD3_N

Domain

6,773

false

This region of tetratricopeptide (TPR)-like repeats is found at the N-terminal of human 26S proteasome non-ATPase regulatory subunit 3 (PSMD3) and similar eukaryotic sequences. PSMD3 is a component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins [ ]. Int...

[]

0

[ "PFAM" ]

[ "PF25573" ]

[ "TPR_PSMD3_N" ]

[ 6773 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-1169091", "R-BTA-1234176", "R-BTA-1236978", "R-BTA-174084", "R-BTA-174154", "R-BTA-174178", "R-BTA-174184", "R-BTA-187577", "R-BTA-195253", "R-BTA-202424", "R-BTA-2467813", "R-BTA-2871837", "R-BTA-349425", "R-BTA-350562", "R-BTA-382556", "R-BTA-450408", "R-BTA-4608870", "R-B...

[ "REACTOME:R-BTA-1169091", "REACTOME:R-BTA-1234176", "REACTOME:R-BTA-1236978", "REACTOME:R-BTA-174084", "REACTOME:R-BTA-174154", "REACTOME:R-BTA-174178", "REACTOME:R-BTA-174184", "REACTOME:R-BTA-187577", "REACTOME:R-BTA-195253", "REACTOME:R-BTA-202424", "REACTOME:R-BTA-2467813", "REACTOME:R-BTA...

300

[ "3jck", "3jco", "3jcp", "4cr2", "4cr3", "4cr4", "5a5b", "5gjq", "5gjr", "5l4k", "5ln3", "5m32", "5mpb", "5mpc", "5mpd", "5mpe", "5t0c", "5t0g", "5t0h", "5t0i", "5t0j", "5vfp", "5vfq", "5vfr", "5vfs", "5vft", "5vfu", "5vgz", "5vhf", "5vhh", "5vhi", "5vhs"...

110

[ "PUB00016866", "PUB00034667", "PUB00034668", "PUB00043308", "PUB00085267", "PUB00086026", "PUB00147862", "PUB00151985", "PUB00152659", "PUB00160701" ]

[ "15571806", "15890341", "9741626", "16566573", "27342858", "28583440", "1317798", "29398115", "26744777", "32783951" ]

[ "The proteasome: a proteolytic nanomachine of cell regulation and waste disposal.", "Proteasome plasticity.", "A subcomplex of the proteasome regulatory particle required for ubiquitin-conjugate degradation and related to the COP9-signalosome and eIF3.", "Effects of tumor necrosis factor-alpha on the 26S prot...

[ 2004, 2005, 1998, 2006, 2016, 2017, 1992, 2018, 2016, 2020 ]

10

[]

0

null

[ "Eukaryota" ]

[ 6773 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 8, 1, 1, 4, 9, 5, 1, 10, 2, 1, 1, 24 ]

12

true

Domain

26S proteasome non-ATPase regulatory subunit 3, N-terminal TPR repeats

TPR_PSMD3_N

7

IPR057986

57,986

Zinc finger protein Rlf/292/654, TPR repeats

TPR_Rlf/292/654

Domain

3,536

false

This region of tetratricopeptide (TPR)-like repeats is found in human Zinc finger protein Rlf/292/654 and similar proteins. These proteins may be involved in transcriptional regulation.

[]

0

[ "PFAM" ]

[ "PF25580" ]

[ "TPR_Rlf" ]

[ 3536 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bilateria" ]

[ 3536 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 9, 10, 7, 7 ]

4

true

Domain

Zinc finger protein Rlf/292/654, TPR repeats

TPR_Rlf/292/654

9

IPR057987

57,987

E3 ubiquitin-protein ligase RNF123/RKP, TPR repeat

TPR_RNF123/RKP

Domain

2,514

false

This is a region of tetratricopeptide (TPR)-like repeats found in human E3 ubiquitin-protein ligase RNF123 and similar eukaryotic proteins including E3 ubiquitin-protein ligase RKP from plants. RNF123 is the catalytic subunit of the KPC complex and functions as an E3 ubiquitin-protein ligase that promotes the ubiquitin...

[]

0

[ "PFAM" ]

[ "PF25576" ]

[ "TPR_RNF123" ]

[ 2514 ]

1

[ "EC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "2.3.2.27", "PWY-7511", "R-HSA-5689880", "R-HSA-983168", "R-MMU-5689880", "R-MMU-983168", "R-RNO-5689880", "R-RNO-983168" ]

[ "EC:2.3.2.27", "METACYC:PWY-7511", "REACTOME:R-HSA-5689880", "REACTOME:R-HSA-983168", "REACTOME:R-MMU-5689880", "REACTOME:R-MMU-983168", "REACTOME:R-RNO-5689880", "REACTOME:R-RNO-983168" ]

8

[]

0

[ "PUB00086162", "PUB00086163", "PUB00086167", "PUB00086396", "PUB00086397", "PUB00098097", "PUB00135879" ]

[ "15531880", "25860612", "26365341", "19000158", "18005227", "27312109", "16227581" ]

[ "Cytoplasmic ubiquitin ligase KPC regulates proteolysis of p27(Kip1) at G1 phase.", "KPC1-mediated ubiquitination and proteasomal processing of NF-κB1 p105 to p50 restricts tumor growth.", "Identification of a Recognizable Progressive Skeletal Dysplasia Caused by RSPRY1 Mutations.", "RKP, a RING finger E3 lig...

[ 2004, 2015, 2015, 2009, 2008, 2016, 2005 ]

7

[]

0

null

[ "Eukaryota" ]

[ 2514 ]

1

[ "Arabidopsis thaliana", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 4, 4, 2, 3, 3, 4, 3, 9 ]

8

true

Domain

E3 ubiquitin-protein ligase RNF123/RKP, TPR repeat

TPR_RNF123/RKP

3

IPR057988

57,988

PBCV-1 P7, disulphide-bonded domain

PBCV1_P7

Domain

41

false

This entry represents a small disulphide-bonded subdomain in multiple copies of the P7 protein of Paramecium bursaria chlorella virus 1 (PBCV-1). In the viral capsid, P7 is situated at the conjunction of capsomers b, c, and e, glueing these three capsomers together within the pentasymmetron. This subdomain plays a cruc...

[]

0

[ "PFAM" ]

[ "PF25636" ]

[ "PBCV1_P7" ]

[ 41 ]

1

[]

0

[ "6ncl" ]

1

[ "PUB00154526" ]

[ "30674888" ]

[ "Near-atomic structure of a giant virus." ]

[ 2019 ]

1

[]

0

null

[ "Chlorovirus", "Eukaryota" ]

[ 30, 11 ]

2

[]

0

true

Domain

PBCV-1 P7, disulphide-bonded domain

PBCV1_P7

9

IPR057989

57,989

RPAP1/MINIYO-like, TPR repeats

TPR_RPAP1/MINIYO-like

Domain

2,949

false

This region of tetratricopeptide (TPR)-like repeats is found in human RNA polymerase II-associated protein 1 (RPAP1), Transcriptional elongation regulator MINIYO from Arabidopsis thaliana and similar eukaryotic proteins. RPAP1 is required for interaction of the RNA polymerase II complex with acetylated histone H3 [ ]. ...

[]

0

[ "PFAM" ]

[ "PF25766" ]

[ "TPR_RPAP1" ]

[ 2949 ]

1

[]

0

[]

0

[ "PUB00077149", "PUB00155353" ]

[ "17643375", "21620701" ]

[ "Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme.", "A molecular switch for initiating cell differentiation in Arabidopsis." ]

[ 2007, 2011 ]

2

[]

0

null

[ "Eukaryota" ]

[ 2949 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 6, 2, 2, 4, 2, 2, 4, 2, 12 ]

9

true

Domain

RPAP1/MINIYO-like, TPR repeats

TPR_RPAP1/MINIYO-like

9

IPR057990

57,990

SYO1-like, TPR repeats

TPR_SYO1

Domain

2,930

false

This is a region of tetratricopeptide (TPR)-like repeats found in Synchronised import protein 1 from Saccharomyces cerevisiae (SYO1), human HEAT repeat-containing protein 3 (HEATR3) and similar eukaryotic proteins. SYO1 and HEATR3 are involved in ribosome biogenesis and nuclear import, functioning as adaptor proteins t...

[]

0

[ "PFAM" ]

[ "PF25567" ]

[ "TPR_SYO1" ]

[ 2930 ]

1

[]

0

[ "4gmn", "4gmo", "5aff", "7ozs" ]

4

[ "PUB00123344", "PUB00151834", "PUB00160702", "PUB00160703", "PUB00160882" ]

[ "23118189", "28572639", "25849277", "31226277", "35213692" ]

[ "Synchronizing nuclear import of ribosomal proteins with ribosome assembly.", "Construction of novel repeat proteins with rigid and predictable structures using a shared helix method.", "Symportin 1 chaperones 5S RNP assembly during ribosome biogenesis by occupying an essential rRNA-binding site.", "Structura...

[ 2012, 2017, 2015, 2019, 2022 ]

5

[]

0

null

[ "Eukaryota" ]

[ 2930 ]

1

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 2, 1, 2, 6, 1, 3, 1, 1 ]

8

true

Domain

SYO1-like, TPR repeats

TPR_SYO1

6

IPR057991

57,991

Transcription initiation factor TFIID subunit 2, TPR repeats

TPR_TAF2_C

Domain

5,529

false

This is a region of tetratricopeptide (TPR)-like repeats found towards the C-terminal end of human Transcription initiation factor TFIID subunit 2 (TAF2) and similar eukaryotic sequences. In yeast, TAF2 functions as a component of the DNA-binding general transcription factor complex TFIID. Its binding to a promoter, wh...

[]

0

[ "PFAM" ]

[ "PF25577" ]

[ "TPR_TAF2_C" ]

[ 5529 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-CEL-674695", "R-CEL-73776", "R-CEL-73779", "R-CEL-75953", "R-CEL-76042", "R-DME-674695", "R-DME-6804756", "R-DME-73776", "R-DME-73779", "R-DME-75953", "R-DME-76042", "R-HSA-167161", "R-HSA-167162", "R-HSA-167172", "R-HSA-674695", "R-HSA-6804756", "R-HSA-73776", "R-HSA-73779", ...

[ "REACTOME:R-CEL-674695", "REACTOME:R-CEL-73776", "REACTOME:R-CEL-73779", "REACTOME:R-CEL-75953", "REACTOME:R-CEL-76042", "REACTOME:R-DME-674695", "REACTOME:R-DME-6804756", "REACTOME:R-DME-73776", "REACTOME:R-DME-73779", "REACTOME:R-DME-75953", "REACTOME:R-DME-76042", "REACTOME:R-HSA-167161", ...

36

[ "5fur", "6hqa", "6mzc", "6mzl", "6mzm", "7edx", "7eg7", "7eg8", "7eg9", "7ega", "7egb", "7egc", "7egd", "7ege", "7egh", "7egi", "7egj", "7ena", "7enc", "8gxq", "8gxs", "8wak", "8wal", "8wan", "8wao", "8wap", "8waq", "8war", "8was" ]

29

[ "PUB00098146", "PUB00101058", "PUB00122513", "PUB00125866", "PUB00160919" ]

[ "30442764", "33795473", "30405110", "9774672", "9418870" ]

[ "Structure of human TFIID and mechanism of TBP loading onto promoter DNA.", "Structural insights into preinitiation complex assembly on core promoters.", "Molecular structure of promoter-bound yeast TFIID.", "Novel cofactors and TFIIA mediate functional core promoter selectivity by the human TAFII150-containi...

[ 2018, 2021, 2018, 1998, 1998 ]

5

[]

0

null

[ "Eukaryota" ]

[ 5529 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 9, 1, 3, 2, 11, 2, 1, 1, 4, 1, 1, 4 ]

12

true

Domain

Transcription initiation factor TFIID subunit 2, TPR repeats

TPR_TAF2_C

5

IPR057992

57,992

E3 ubiquitin-protein ligase synoviolin-like, TPR repeats

TPR_SYVN1_N

Domain

7,968

false

This region of tetratricopeptide (TPR)-like repeats is found at the N-terminal end of human E3 ubiquitin-protein ligase synoviolin (SYVN1), ERAD-associated E3 ubiquitin-protein ligase HRD1 from Saccharomyces cerevisiae, and E3 ubiquitin-protein ligase AMFR, and similar proteins mainly found in animals. SYVN1 accepts ub...

[]

0

[ "PFAM" ]

[ "PF25563" ]

[ "TPR_SYVN1_N" ]

[ 7968 ]

1

[ "EC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "2.3.2.27", "PWY-7511", "R-CEL-5358346", "R-DME-5358346", "R-DRE-532668", "R-DRE-5358346", "R-HSA-381038", "R-HSA-532668", "R-HSA-5358346", "R-HSA-5362768", "R-HSA-901032", "R-MMU-532668", "R-MMU-5358346", "R-SPO-5358346" ]

[ "EC:2.3.2.27", "METACYC:PWY-7511", "REACTOME:R-CEL-5358346", "REACTOME:R-DME-5358346", "REACTOME:R-DRE-532668", "REACTOME:R-DRE-5358346", "REACTOME:R-HSA-381038", "REACTOME:R-HSA-532668", "REACTOME:R-HSA-5358346", "REACTOME:R-HSA-5362768", "REACTOME:R-HSA-901032", "REACTOME:R-MMU-532668", "R...

14

[ "5v6p", "6vjy", "6vjz", "6vk0", "6vk1", "8kes", "8ket", "8kev", "9lwu", "9og0", "9uav" ]

11

[ "PUB00133402", "PUB00133404", "PUB00138348", "PUB00158391", "PUB00160883", "PUB00160884", "PUB00160885", "PUB00160886", "PUB00160887" ]

[ "19103148", "11724934", "12670940", "22607976", "24424410", "26471130", "27827840", "28827405", "28604676" ]

[ "CYP3A4 ubiquitination by gp78 (the tumor autocrine motility factor receptor, AMFR) and CHIP E3 ligases.", "The tumor autocrine motility factor receptor, gp78, is a ubiquitin protein ligase implicated in degradation from the endoplasmic reticulum.", "Overexpression of the tumor autocrine motility factor recepto...

[ 2009, 2001, 2003, 2012, 2014, 2016, 2016, 2017, 2017 ]

9

[]

0

null

[ "Eukaryota" ]

[ 7968 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 20, 1, 7, 3, 10, 9, 1, 5, 7, 1, 1, 57 ]

12

true

Domain

E3 ubiquitin-protein ligase synoviolin-like, TPR repeats

TPR_SYVN1_N

7

IPR057993

57,993

HD-Zip IV, C-terminal domain

HD-Zip_IV_C

Domain

8,700

false

This entry represents the C-terminal domain in transcription factors of the class IV homeodomain-leucine zipper (HD-Zip IV) including GLABRA2, ANTHOCYANINLESS2 (ANL2), ARABIDOPSIS THALIANA MERISTEM LAYER1 (ATML1), PROTODERMAL FACTOR2 (PDF2), ROC1-9 and HDG1-12, found in plants. This domain is predicted to fold into a c...

[]

0

[ "PFAM" ]

[ "PF25797" ]

[ "PDF2_C" ]

[ 8700 ]

1

[]

0

[]

0

[ "PUB00092751", "PUB00092752", "PUB00092753", "PUB00092754", "PUB00160888", "PUB00160889" ]

[ "11844112", "10402424", "12505995", "25766904", "23590515", "11846882" ]

[ "Entopically additive expression of GLABRA2 alters the frequency and spacing of trichome initiation.", "ANTHOCYANINLESS2, a homeobox gene affecting anthocyanin distribution and root development in Arabidopsis.", "Regulation of shoot epidermal cell differentiation by a pair of homeodomain proteins in Arabidopsis...

[ 2002, 1999, 2003, 2015, 2013, 2002 ]

6

[]

0

null

[ "Streptophyta" ]

[ 8700 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 107, 30, 109 ]

3

true

Domain

HD-Zip IV, C-terminal domain

HD-Zip_IV_C

7

IPR057994

57,994

Major capsid protein 1, PFV

PFV_capsid

Family

2

false

The Pyrobaculum filamentous virus Major capsid protein is involved in the formation of a helical, filamentous nucleocapsid that measures approximately 400 nm in length and 20 nm in width. This family of proteins works in conjunction with capsid protein 2 to wrap around viral DNA, maintaining it in an A-form. This struc...

[]

0

[ "PFAM" ]

[ "PF25634" ]

[ "PFV_capsid" ]

[ 2 ]

1

[]

0

[ "6v7b" ]

1

[ "PUB00160651" ]

[ "32368353" ]

[ "Structure of a filamentous virus uncovers familial ties within the archaeal virosphere." ]

[ 2020 ]

1

[]

0

null

[ "Alphatristromavirus" ]

[ 2 ]

1

[]

0

true

Family

Major capsid protein 1, PFV

PFV_capsid

8

IPR057995

57,995

Gp11, Phage 80a

Phage_80a_gp11

Family

27

false

This entry represents a small family of phage proteins that include gp11 from Staphylococcus phage 80alpha. This protein is composed of three α-helices and appears to adopt a confident homotrimeric arrangement in structure prediction. The function of this protein is unknown.

[]

0

[ "PFAM" ]

[ "PF25605" ]

[ "Phage_80a_gp11" ]

[ 27 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacillales", "Caudoviricetes" ]

[ 12, 15 ]

2

[]

0

true

Family

Gp11, Phage 80a

Phage_80a_gp11

2

IPR057996

57,996

Depolymerase 2 capsule K5-specific, C-terminal domain

K52_C

Domain

71

false

This entry represents the C-terminal β-sandwich domain found in bacteriophage-encoded depolymerase 2, capsule K5-specific (K52). This domain is found in phages with dual host specificity, where each phage encodes two different capsule depolymerases with specificity for different capsular types. This domain is C-termina...

[]

0

[ "PFAM" ]

[ "PF25692" ]

[ "Phage_depo_C" ]

[ 71 ]

1

[]

0

[]

0

[ "PUB00160652", "PUB00160653" ]

[ "28676686", "30706654" ]

[ "Two T7-like Bacteriophages, K5-2 and K5-4, Each Encodes Two Capsule Depolymerases: Isolation and Functional Characterization.", "Identification of three podoviruses infecting Klebsiella encoding capsule depolymerases that digest specific capsular types." ]

[ 2017, 2019 ]

2

[]

0

null

[ "Bacteria", "Caudoviricetes", "Ecdysozoa", "metagenomes" ]

[ 48, 13, 2, 8 ]

4

[]

0

true

Domain

Depolymerase 2 capsule K5-specific, C-terminal domain

K52_C

1

IPR057997

57,997

Gp33 protein

Gp33

Family

8

false

This entry represents the Gene 33 protein (Gp33) found in Bacillus phage SP01 and related bacteriophages. Gp33 from Bacillus phage SP01 is thought to act as a regulatory subunit of the Bacillus subtilis RNA polymerase during viral infection [ ]. Some homologs in other bacteriophages are annotated as sigma factor access...

[]

0

[ "PFAM" ]

[ "PF25742" ]

[ "Phage_Gene33" ]

[ 8 ]

1

[]

0

[ "8xa6", "8xa7" ]

2

[ "PUB00160654" ]

[ "6441846" ]

[ "Bacteriophage SPO1 genes 33 and 34. Location and primary structure of genes encoding regulatory subunits of Bacillus subtilis RNA polymerase." ]

[ 1984 ]

1

[]

0

null

[ "Spounavirinae" ]

[ 8 ]

1

[]

0

true

Family

Gp33 protein

Gp33

3

IPR057998

57,998

Gp168

Family

42

false

This entry represents a bacteriophage protein family that includes Gp168 from phage Twort, which inhibits bacterial DNA replication. The protein exists as a hexamer in solution but binds as a dimer to the bacterial β-clamp, a protein essential for DNA replication. Unlike other β-clamp binding proteins that interact wit...

[]

0

[ "PFAM" ]

[ "PF25696" ]

[ "Phage_Gp168" ]

[ 42 ]

1

[]

0

[ "7evp" ]

1

[ "PUB00160655" ]

[ "34614154" ]

[ "Bacteriophage Twort protein Gp168 is a β-clamp inhibitor by occupying the DNA sliding channel." ]

[ 2021 ]

1

[]

0

null

[ "Caudoviricetes" ]

[ 42 ]

1

[]

0

true

Family

Gp168

3

IPR057999

57,999

Gp49

Family

402

false

This entry represents the Gene 49 protein (Gp49) found in Mycobacteriophage D29 and L5. The protein contains disordered regions at both the N-terminal (residues 1-49) and internally (residues 114-157). The C-terminal region contains several conserved cysteine residues that may be functionally important. The specific fu...

[]

0

[ "PFAM" ]

[ "PF25690" ]

[ "Phage_gp49" ]

[ 402 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Viruses" ]

[ 62, 340 ]

2

[]

0

true

Family

Gp49

5

IPR058000

58,000

Gp58, bacteriophage

Gp58_bacteriophage

Family

7

false

This entry represents a small, highly conserved family of bacteriophage proteins including Gp58 protein from Bacillus phage SP01. The function of this protein remains unknown. The family is characterised by a conserved CxxC motif (CNGCGK) followed by another conserved cysteine, suggesting a potential metal-binding role...

[]

0

[ "PFAM" ]

[ "PF25745" ]

[ "Phage_GP58" ]

[ 7 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Herelleviridae" ]

[ 7 ]

1

[]

0

true

Family

Gp58, bacteriophage

Gp58_bacteriophage

3

IPR058001

58,001

Head completion protein 1

HCP1

Family

188

false

This entry represents the phage Head completion protein 1 (HCP1) that forms part of the connector complex between the phage capsid and tail in lactococcal phages. This protein has been characterised in Lactococcus phage p2, a member of the Skunavirus genus (formerly 936 group of lactococcal phages), which infects Lacto...

[]

0

[ "PFAM" ]

[ "PF25714" ]

[ "Phage_HCP1" ]

[ 188 ]

1

[]

0

[]

0

[ "PUB00054437", "PUB00082566" ]

[ "20351260", "24027307" ]

[ "Structure of lactococcal phage p2 baseplate and its mechanism of activation.", "Structure, adsorption to host, and infection mechanism of virulent lactococcal phage p2." ]

[ 2010, 2013 ]

2

[]

0

null

[ "Bacteria", "Caudoviricetes" ]

[ 13, 175 ]

2

[]

0

true

Family

Head completion protein 1

HCP1

5

IPR058002

58,002

Gp82

Family

556

false

This entry represents a family of proteins related to Gene 82 protein (Gp82) from Mycobacterium phage L5. The function of this protein is currently unknown. It is found in mycobacteriophages, which are viruses that infect Mycobacterium species. Structure prediction suggests this protein may form a homodimer.

[]

0

[ "PFAM" ]

[ "PF25735" ]

[ "Phage_L5_gp82" ]

[ 556 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Halorarum halophilum", "Ostreococcus tauri", "Viruses", "unclassified sequences" ]

[ 212, 1, 1, 327, 15 ]

5

[]

0

true

Family

Gp82

2

IPR058003

58,003

Tail tubular protein gp12

Phage_gp12

Family

1,252

false

This entry represents the tail tubular protein gp12 protein family found in phages. Gp12 exists as a monomer in solution, but assembles into a hexameric nozzle structure when incorporated into the tail complex. In phage T7, six copies of gp12 assemble into a hexameric tube attached to the adaptor protein ring (gp11) at...

[]

0

[ "PFAM" ]

[ "PF25675" ]

[ "Phage_nozzle" ]

[ 1252 ]

1

[]

0

[ "6r21", "7boy", "7ey7", "7ey9", "7y1c", "7y22", "8e4g", "8es4", "8i4m", "8vbx", "9jyz", "9jz0", "9vvr" ]

13

[ "PUB00081256", "PUB00151527", "PUB00160656", "PUB00160904" ]

[ "23884409", "32266588", "39351541", "26283379" ]

[ "Structural characterization of the bacteriophage T7 tail machinery.", "Structural changes of a bacteriophage upon DNA packaging and maturation.", "Ejectosome of Pectobacterium bacteriophage ΦM1.", "Structural remodeling of bacteriophage T4 and host membranes during infection initiation." ]

[ 2013, 2020, 2024, 2015 ]

4

[]

0

null

[ "Bacteria", "Eukaryota", "Viruses", "metagenomes" ]

[ 168, 5, 1070, 9 ]

4

[]

0

true

Family

Tail tubular protein gp12

Phage_gp12

7

IPR058004

58,004

ORF43.1

Family

82

false

This entry represents an uncharacterised protein found in the 3' region of the regA gene (ORF43.1) in Enterobacteria phage RB18 and related proteins. Their function remains unknown.

[]

0

[ "PFAM" ]

[ "PF25760" ]

[ "Phage_RB18_ORF43" ]

[ 82 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Viruses" ]

[ 82 ]

1

[]

0

true

Family

ORF43.1

3

IPR058005

58,005

Repressor protein C

Repressor_C

Family

42

false

This entry represents the repressor protein (c) of the Streptomyces temperate phage phi-c31. This protein is involved in the establishment and maintenance of lysogeny. This protein contains a DNA-binding helix-turn-helix motif near the C-terminal. Lysogens of phi-c31 are not inducible by UV irradiation or by mitomycin ...

[]

0

[ "PFAM" ]

[ "PF25746" ]

[ "Phage_Repressor_c" ]

[ 42 ]

1

[]

0

[]

0

[ "PUB00160657", "PUB00160903" ]

[ "3185504", "11972788" ]

[ "The repressor gene (c) of the Streptomyces temperate phage phi c31: nucleotide sequence, analysis and functional cloning.", "Dam-dependent phase variation of Ag43 in Escherichia coli is altered in a seqA mutant." ]

[ 1988, 2002 ]

2

[]

0

null

[ "Caudoviricetes", "Streptomycetaceae" ]

[ 17, 25 ]

2

[]

0

true

Family

Repressor protein C

Repressor_C

6

IPR058006

58,006

1.05 protein

1.05

Family

299

false

This entry represents an uncharacterised gene 1.05 protein found in Enterobacteria phage T3. The function of this small phage protein is currently unknown. Structure prediction suggests that this region forms a compact domain composed of 6 β-strands that form a small β-sandwich.

[]

0

[ "PFAM" ]

[ "PF25755" ]

[ "Phage_T3_1_05" ]

[ 299 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Pseudomonadati", "Viruses" ]

[ 3, 296 ]

2

[]

0

true

Family

1.05 protein

1.05

7

IPR058007

58,007

Gp5.9

Family

356

false

This entry represents a group of phage proteins that act as a DNA mimic to inhibit the bacterial RecBCD complex, encoded by gene 5.9 (Gp5.9). The T7 gp5.9 protein adopts a parallel coiled-coil architecture with an N-terminal β-sheet. The protein's highly acidic surface mimics DNA structure, allowing it to compete with ...

[]

0

[ "PFAM" ]

[ "PF25708" ]

[ "Phage_T7_Gp5_9" ]

[ 356 ]

1

[]

0

[ "8b1r", "9gmb", "9gmd" ]

3

[ "PUB00160658" ]

[ "36533901" ]

[ "Structures of RecBCD in complex with phage-encoded inhibitor proteins reveal distinctive strategies for evasion of a bacterial immunity hub." ]

[ 2022 ]

1

[]

0

null

[ "Bacteria", "Viruses", "metagenomes" ]

[ 77, 264, 15 ]

3

[]

0

true

Family

Gp5.9

7

IPR058008

58,008

Phage tail protein, C-terminal domain

Gp26_C

Domain

1,093

false

This entry represents a C-terminal domain that is found in a range of probable phage tail proteins, including Gp26 from Bacteriophage T1 and from Escherichia phage vB_EcoP_SU10 [ ]. The domain forms an elaborated β-sandwich domain. Members of this entry are found in tailed bacteriophages and prophages mainly found in p...

[]

0

[ "PFAM" ]

[ "PF25670" ]

[ "Phage_tail_C_2" ]

[ 1093 ]

1

[]

0

[ "7z47", "7z4a", "7z4b", "7z4f" ]

4

[ "PUB00153713" ]

[ "36153309" ]

[ "Tail proteins of phage SU10 reorganize into the nozzle for genome delivery." ]

[ 2022 ]

1

[]

0

null

[ "Bacteria", "Coniosporium tulheliwenetii", "Viruses" ]

[ 1003, 1, 89 ]

3

[]

0

true

Domain

Phage tail protein, C-terminal domain

Gp26_C

7

IPR058010

58,010

Y01A

Family

311

false

This entry represents a family of small proteins found in T4-like bacteriophages, including Y01A proteins. The function of these proteins is currently unknown. The proteins are approximately 12 kDa in size and are highly conserved across a wide range of phages that infect different bacterial hosts, including Enterobact...

[]

0

[ "PFAM" ]

[ "PF25693" ]

[ "Phage_Y01A" ]

[ 311 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Flagellimonas marina", "Viruses" ]

[ 1, 310 ]

2

[]

0

true

Family

Y01A

6

IPR058011

58,011

Major capsid protein, Phi29

Phi29_MCP

Family

236

false

This entry represents the major capsid protein found in phi29-like bacteriophages. These proteins assemble to form the icosahedral capsid structure of the virion. Based on the characterised member from Staphylococcus phage 44AHJD ( ), these phages belong to the Podoviridae family with short, non-contractile tails. The ...

[]

0

[ "PFAM" ]

[ "PF25622" ]

[ "Phi29_MCP" ]

[ 236 ]

1

[]

0

[ "6iat", "6iaw", "6ib1", "6q3g", "6qvk", "6qyd", "6qz0", "8egt", "8f2m", "8f2n", "8f2o" ]

11

[ "PUB00152156" ]

[ "31663016" ]

[ "Structure and genome ejection mechanism of Staphylococcus aureus phage P68." ]

[ 2019 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "Viruses", "metagenomes" ]

[ 25, 18, 191, 2 ]

4

[]

0

true

Family

Major capsid protein, Phi29

Phi29_MCP

6

IPR058012

58,012

Major outer capsid P8

MOCP_P8

Family

47

false

This entry represents the major outer capsid protein P8 from dsRNA bacteriophage phi6, which forms the T=13 shell of the nucleocapsid. The protein consists of two α-helical domains: an N-terminal peripheral domain and a C-terminal core domain, joined by a ~10-residue linker that allows the trimer to adopt either a clos...

[]

0

[ "PFAM" ]

[ "PF25655" ]

[ "Phi6_P8" ]

[ 47 ]

1

[]

0

[ "5muu", "6hy0" ]

2

[ "PUB00152052", "PUB00160902" ]

[ "28287099", "22379079" ]

[ "Double-stranded RNA virus outer shell assembly by bona fide domain-swapping.", "Bacteriophage ϕ6 nucleocapsid surface protein 8 interacts with virus-specific membrane vesicles containing major envelope protein 9." ]

[ 2017, 2012 ]

2

[]

0

null

[ "Cystoviridae", "Rhodoblastus acidophilus" ]

[ 46, 1 ]

2

[]

0

true

Family

Major outer capsid P8

MOCP_P8

9

IPR058013

58,013

Gp119

Family

14

false

This entry represents the vertex-binding protein gp119 from the jumbo bacteriophage PhiKZ that infects Pseudomonas aeruginosa. This α-helical protein forms part of the vertex-binding complex attached to the inner surface of the viral capsid. Gp119, along with gp28 and the gp85 dimer, forms a sandwich structure at the c...

[]

0

[ "PFAM" ]

[ "PF25619" ]

[ "PhiKZ_gp119" ]

[ 14 ]

1

[]

0

[ "8y6v" ]

1

[ "PUB00160659", "PUB00160856" ]

[ "36433970", "39095371" ]

[ "High-resolution reconstruction of a Jumbo-bacteriophage infecting capsulated bacteria using hyperbranched tail fibers.", "Capsid structure of bacteriophage ΦKZ provides insights into assembly and stabilization of jumbo phages." ]

[ 2022, 2024 ]

2

[]

0

null

[ "Viruses" ]

[ 14 ]

1

[]

0

true

Family

Gp119

2

IPR058014

58,014

Gp244

Family

10

false

This entry represents the capsid decoration protein gp244 from jumbo bacteriophage PhiKZ that infects Pseudomonas aeruginosa. This protein is located in the outer surface of the viral capsid, specifically positioned on the top of each pentameric capsomer. The structure consists of a core domain and an N-terminal arm. T...

[]

0

[ "PFAM" ]

[ "PF25621" ]

[ "PhiKZ_gp244" ]

[ 10 ]

1

[]

0

[ "8y6v" ]

1

[ "PUB00160659", "PUB00160856" ]

[ "36433970", "39095371" ]

[ "High-resolution reconstruction of a Jumbo-bacteriophage infecting capsulated bacteria using hyperbranched tail fibers.", "Capsid structure of bacteriophage ΦKZ provides insights into assembly and stabilization of jumbo phages." ]

[ 2022, 2024 ]

2

[]

0

null

[ "Chimalliviridae" ]

[ 10 ]

1

[]

0

true

Family

Gp244

8

IPR058015

58,015

Gp35

Family

6

false

This entry represents the capsid decoration protein gp35 from jumbo bacteriophage PhiKZ that infects Pseudomonas aeruginosa. This protein decorates the outer surface of the viral capsid near the vertices. Only the C-terminal portion of gp35 (residues 160-266) was resolved in the cryo-EM structure, as the N-terminal por...

[]

0

[ "PFAM" ]

[ "PF25616" ]

[ "PhiKZ_gp35" ]

[ 6 ]

1

[]

0

[ "8y6v" ]

1

[ "PUB00160659", "PUB00160856" ]

[ "36433970", "39095371" ]

[ "High-resolution reconstruction of a Jumbo-bacteriophage infecting capsulated bacteria using hyperbranched tail fibers.", "Capsid structure of bacteriophage ΦKZ provides insights into assembly and stabilization of jumbo phages." ]

[ 2022, 2024 ]

2

[]

0

null

[ "Viruses" ]

[ 6 ]

1

[]

0

true

Family

Gp35

7

IPR058016

58,016

Gp85

Family

13

false

This entry represents the vertex-binding protein gp85 from jumbo bacteriophage PhiKZ that infects Pseudomonas aeruginosa. This protein forms a homodimer and functions as a key component of the vertex-binding complex attached to the inner surface of the viral capsid. The gp85 dimer, along with gp28 and gp119, forms a sa...

[]

0

[ "PFAM" ]

[ "PF25615" ]

[ "PhiKZ_gp85" ]

[ 13 ]

1

[]

0

[ "8y6v" ]

1

[ "PUB00160659", "PUB00160856" ]

[ "36433970", "39095371" ]

[ "High-resolution reconstruction of a Jumbo-bacteriophage infecting capsulated bacteria using hyperbranched tail fibers.", "Capsid structure of bacteriophage ΦKZ provides insights into assembly and stabilization of jumbo phages." ]

[ 2022, 2024 ]

2

[]

0

null

[ "Viruses" ]

[ 13 ]

1

[]

0

true

Family

Gp85

5

IPR058017

58,017

AAA+ ATPase At3g28540-like, C-terminal domain

At3g28540-like_C

Domain

11,178

false

This domain is found at the C-terminal end of AAA-ATPase At3g28540 from Arabidopsis thaliana and similar plant proteins. This domain is predicted to have a helical bundle and is found associated with . The AAA ATPase BCS1 subfamily is a group of proteins that belong to the larger AAA ATPase family. These proteins are c...

[]

0

[ "PFAM" ]

[ "PF25568" ]

[ "AAA_lid_At3g28540" ]

[ 11178 ]

1

[ "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC" ]

[ "3.6.1.-", "PWY-5757", "PWY-6147", "PWY-6383", "PWY-6797", "PWY-7206", "PWY-7419", "PWY-7539", "PWY-7719", "PWY-7821", "PWY-8289" ]

[ "EC:3.6.1.-", "METACYC:PWY-5757", "METACYC:PWY-6147", "METACYC:PWY-6383", "METACYC:PWY-6797", "METACYC:PWY-7206", "METACYC:PWY-7419", "METACYC:PWY-7539", "METACYC:PWY-7719", "METACYC:PWY-7821", "METACYC:PWY-8289" ]

11

[]

0

[ "PUB00057226", "PUB00160900", "PUB00160901" ]

[ "11473577", "20561255", "21359673" ]

[ "AAA+ superfamily ATPases: common structure--diverse function.", "ABA overly-sensitive 5 (ABO5), encoding a pentatricopeptide repeat protein required for cis-splicing of mitochondrial nad2 intron 3, is involved in the abscisic acid response in Arabidopsis.", "Activation of a mitochondrial ATPase gene induces ab...

[ 2001, 2010, 2011 ]

3

[]

0

null

[ "Eukaryota" ]

[ 11178 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 116, 84, 59 ]

3

true

Domain

AAA+ ATPase At3g28540-like, C-terminal domain

At3g28540-like_C

6

IPR058018

58,018

TANC1/2-like, AAA+ ATPase lid domain

AAA_lid_TANC1/2

Domain

7,557

false

This domain is found in Protein TANC1, TANC2 and similar proteins mainly found in animals. This domain is often found associated with a long region of ankyrin repeats ( ). TANC proteins function as scaffolding components in the postsynaptic density and dendritic spines. These proteins are involved in the organisation a...

[]

0

[ "PFAM" ]

[ "PF25520" ]

[ "AAA_lid_TANC1" ]

[ 7557 ]

1

[]

0

[]

0

[ "PUB00160897", "PUB00160898", "PUB00160899" ]

[ "21068316", "22182840", "38092135" ]

[ "Regulation of dendritic spines, spatial memory, and embryonic development by the TANC family of PSD-95-interacting proteins.", "Drosophila and mammalian models uncover a role for the myoblast fusion gene TANC1 in rhabdomyosarcoma.", "Tanc1/2 TPR domain interacts with Myo18a C-terminus and undergoes liquid-liqu...

[ 2010, 2012, 2024 ]

3

[]

0

null

[ "Cyanophyceae", "Opisthokonta" ]

[ 19, 7538 ]

2

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 44, 14, 6, 6, 12 ]

5

true

Domain

TANC1/2-like, AAA+ ATPase lid domain

AAA_lid_TANC1/2

1

IPR058019

58,019

Capsid protein, anulavirus

Anulav_capsid

Family

11

false

The Anulavirus capsid protein family is involved in the formation of a quasi-spherical capsid structure, typically ranging from 25 to 35 nanometers in diameter. This structural protein self-assembles to create the protective shell of a virus, which encases the viral genome. The capsid plays a crucial role in the viral ...

[]

0

[ "PFAM" ]

[ "PF25633" ]

[ "Anula_coat" ]

[ 11 ]

1

[]

0

[]

0

[ "PUB00160896" ]

[ "14573820" ]

[ "Complete nucleotide sequence of Pelargonium zonate spot virus and its relationship with the family Bromoviridae." ]

[ 2003 ]

1

[]

0

null

[ "Anulavirus" ]

[ 11 ]

1

[]

0

true

Family

Capsid protein, anulavirus

Anulav_capsid

6

IPR058020

58,020

Minor capsid protein p17

P17

Family

17

false

This entry represents the African swine fever virus minor capsid protein p17. This protein is a component of the viral inner capsid shell, where three copies of p17 encircle each p72 capsomer, anchoring them on the inner membrane and forming a rigid zipper structure that stabilises the capsomers. It is essential for th...

[]

0

[ "PFAM" ]

[ "PF25667" ]

[ "ASFV_P17" ]

[ 17 ]

1

[]

0

[]

0

[ "PUB00160569", "PUB00160570", "PUB00160895" ]

[ "20504920", "35844609", "31624094" ]

[ "African swine fever virus protein p17 is essential for the progression of viral membrane precursors toward icosahedral intermediates.", "African Swine Fever Virus Structural Protein p17 Inhibits cGAS-STING Signaling Pathway Through Interacting With STING.", "Architecture of African swine fever virus and implic...

[ 2010, 2022, 2019 ]

3

[]

0

null

[ "African swine fever virus" ]

[ 17 ]

1

[]

0

true

Family

Minor capsid protein p17

P17

9

IPR058021

58,021

Minor capsid protein p49

P49

Family

21

false

This entry represents the minor capsid protein p49 of African swine fever virus (ASFV). The p49 protein plays an essential role in the formation of infectious virus particles. It is particularly required for the formation of the capsid vertices, where it localises in close proximity. Together with the penton and other ...

[]

0

[ "PFAM" ]

[ "PF25668" ]

[ "ASFV_p49" ]

[ 21 ]

1

[]

0

[]

0

[ "PUB00160571", "PUB00160894", "PUB00160895" ]

[ "10640542", "17005638", "31624094" ]

[ "Characterization of the african swine fever virus protein p49: a new late structural polypeptide.", "Generation of filamentous instead of icosahedral particles by repression of African swine fever virus structural protein pB438L.", "Architecture of African swine fever virus and implications for viral assembly....

[ 2000, 2006, 2019 ]

3

[]

0

null

[ "African swine fever virus" ]

[ 21 ]

1

[]

0

true

Family

Minor capsid protein p49

P49

6

IPR058022

58,022

P15

Family

19

false

This entry represents a putative 15 kDa capsid protein (P15) found in baculoviruses. The protein is encoded by the p15 gene (also annotated as ORF88) in the Orgyia pseudotsugata multicapsid polyhedrosis virus (OpMNPV) genome. This protein is predicted to be a structural component of the viral capsid. The specific funct...

[]

0

[ "PFAM" ]

[ "PF25651" ]

[ "Baculo_P15" ]

[ 19 ]

1

[]

0

[]

0

[ "PUB00160893" ]

[ "9126251" ]

[ "The sequence of the Orgyia pseudotsugata multinucleocapsid nuclear polyhedrosis virus genome." ]

[ 1997 ]

1

[]

0

null

[ "Alphabaculovirus" ]

[ 19 ]

1

[]

0

true

Family

P15

1

IPR058023

58,023

U91

Family

53

false

This entry represents the herpesvirus U91 protein, a membrane protein with two predicted transmembrane helices. U91 is found in HHV-6B, a betaherpesvirus that causes roseola in young children. The protein is localised to the host cell membrane as a multi-pass membrane protein, with transmembrane regions at positions 18...

[]

0

[ "PFAM" ]

[ "PF25686" ]

[ "Betaherpes_U91" ]

[ 53 ]

1

[]

0

[]

0

[ "PUB00019428", "PUB00160892" ]

[ "7747482", "1321205" ]

[ "The DNA sequence of human herpesvirus-6: structure, coding content, and genome evolution.", "The right end of the unique region of the genome of human herpesvirus 6 U1102 contains a candidate immediate early gene enhancer and a homologue of the human cytomegalovirus US22 gene family." ]

[ 1995, 1992 ]

2

[]

0

null

[ "Betaherpesvirinae", "Homo sapiens" ]

[ 52, 1 ]

2

[ "Homo sapiens" ]

[ 1 ]

1

true

Family

U91

9

IPR058024

58,024

G-protein coupled receptor BILF1-like

BILF1-like

Family

67

false

This entry represents the gammaherpesvirus G-protein coupled receptor (GPCR) BILF1 and related virus GPCR. These receptors are constitutively active and signal through Gi type G-proteins. BILF1 is a lytic gene in Epstein-Barr virus (EBV) and inhibits cAMP response element-binding protein (CREB) activation via stimulati...

[]

0

[ "PFAM" ]

[ "PF25732" ]

[ "BILF1" ]

[ 67 ]

1

[]

0

[ "7jhj" ]

1

[ "PUB00160576", "PUB00160577", "PUB00160578", "PUB00160579", "PUB00160580", "PUB00160581", "PUB00160582", "PUB00160583", "PUB00160584", "PUB00160585" ]

[ "15596846", "15596837", "19119421", "20622011", "20543866", "21123379", "23315076", "30647152", "37311461", "18024890" ]

[ "Epstein-Barr virus-encoded BILF1 is a constitutively active G protein-coupled receptor.", "The Epstein-Barr virus BILF1 gene encodes a G protein-coupled receptor that inhibits phosphorylation of RNA-dependent protein kinase.", "The Epstein-Barr virus G-protein-coupled receptor contributes to immune evasion by ...

[ 2005, 2005, 2009, 2010, 2010, 2011, 2013, 2019, 2023, 2007 ]

10

[]

0

null

[ "Gammaherpesvirinae" ]

[ 67 ]

1

[]

0

true

Family

G-protein coupled receptor BILF1-like

BILF1-like

1

IPR058025

58,025

BKRF4

Family

41

false

This entry represents the histone binding protein BKRF4 of the Epstein-Barr virus, which interacts with histone H2A-H2B dimers. BKRF4-HBD binds to H2A-H2B via a triple-anchor binding mode involving the N-terminal region (NTR), the DWP motif (containing D81, W84, P86), and the C-terminal region (CTR). This binding enabl...

[ "GO:0042393" ]

[ "histone binding" ]

[ "molecular_function" ]

1

[ "PFAM" ]

[ "PF25695" ]

[ "BKRF4" ]

[ 41 ]

1

[]

0

[ "7vcl", "7vcq", "7wlp" ]

3

[ "PUB00160586", "PUB00160587", "PUB00160588" ]

[ "35870648", "36067323", "29743367" ]

[ "Epstein-Barr Virus Tegument Protein BKRF4 is a Histone Chaperone.", "Epstein-Barr virus protein BKRF4 restricts nucleosome assembly to suppress host antiviral responses.", "A Screen for Epstein-Barr Virus Proteins That Inhibit the DNA Damage Response Reveals a Novel Histone Binding Protein." ]

[ 2022, 2022, 2018 ]

3

[]

0

null

[ "Lymphocryptovirus" ]

[ 41 ]

1

[]

0

true

Family

BKRF4

4

IPR058026

58,026

BNLF2a

Family

32

false

This entry represents the BNLF2a protein family found in Epstein-Barr virus. BNLF2a is a membrane-associated protein that inhibits TAP-mediated peptide transport into the endoplasmic reticulum for binding to HLA class I molecules. By preventing peptide loading, BNLF2a helps the virus evade detection by cytotoxic T cell...

[ "GO:0005515" ]

[ "protein binding" ]

[ "molecular_function" ]

1

[ "PFAM" ]

[ "PF25740" ]

[ "BNLF2a" ]

[ 32 ]

1

[]

0

[ "9ocg" ]

1

[ "PUB00160589", "PUB00160890", "PUB00160891" ]

[ "19201886", "16490228", "16306603" ]

[ "Specific targeting of the EBV lytic phase protein BNLF2a to the transporter associated with antigen processing results in impairment of HLA class I-restricted antigen presentation.", "The genome of Epstein-Barr virus type 2 strain AG876.", "Genomic sequence analysis of Epstein-Barr virus strain GD1 from a naso...

[ 2009, 2006, 2005 ]

3

[]

0

null

[ "Lymphocryptovirus" ]

[ 32 ]

1

[]

0

true

Family

BNLF2a

5

IPR058027

58,027

Late promoter-activating protein

Lpa

Family

112

false

This entry represents the Late promoter-activating protein (Lpa) from bacteriophage P1. Lpa is a trans-activating factor involved in the late regulation of the P1 lytic growth cycle. It may function as the transcriptional activator of all late P1 functions. The protein has DNA-binding activity [ ].

[ "GO:0003677" ]

[ "DNA binding" ]

[ "molecular_function" ]

1

[ "PFAM" ]

[ "PF25716" ]

[ "BPP1_LPA" ]

[ 112 ]

1

[]

0

[]

0

[ "PUB00045957" ]

[ "1917870" ]

[ "Bacteriophage P1 gene 10 encodes a trans-activating factor required for late gene expression." ]

[ 1991 ]

1

[]

0

null

[ "Enterobacterales", "Punavirus", "feces metagenome" ]

[ 103, 8, 1 ]

3

[]

0

true

Family

Late promoter-activating protein

Lpa

2

IPR058029

58,029

CENPJ, tubulin-binding region

Tubulin-bd_CENPJ

Domain

1,371

false

This region, also known as PN2-3 domain, is found in the human Centrosomal P4.1-associated protein (CPAP, also known as CENPJ). The region represented by this entry binds and caps the longitudinal surface of the tubulin beta-subunit [ ]. This binding site also targeted by fungal and bacterial peptide-like inhibitors of...

[]

0

[ "PFAM" ]

[ "PF25779" ]

[ "Tubulin-bind_CPAP" ]

[ 1371 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-2565942", "R-HSA-380259", "R-HSA-380270", "R-HSA-380284", "R-HSA-380320", "R-HSA-5620912", "R-HSA-6804115", "R-HSA-8854518", "R-MMU-2565942", "R-MMU-380259", "R-MMU-380270", "R-MMU-380284", "R-MMU-380320", "R-MMU-5620912", "R-MMU-6804115", "R-MMU-8854518" ]

[ "REACTOME:R-HSA-2565942", "REACTOME:R-HSA-380259", "REACTOME:R-HSA-380270", "REACTOME:R-HSA-380284", "REACTOME:R-HSA-380320", "REACTOME:R-HSA-5620912", "REACTOME:R-HSA-6804115", "REACTOME:R-HSA-8854518", "REACTOME:R-MMU-2565942", "REACTOME:R-MMU-380259", "REACTOME:R-MMU-380270", "REACTOME:R-MM...

16

[ "5eib", "5itz", "7q1e", "7q1f", "7z0f", "7z0g" ]

6

[ "PUB00033370", "PUB00052372", "PUB00060686", "PUB00101595", "PUB00158960", "PUB00160710", "PUB00160711" ]

[ "15047868", "17681131", "20531387", "27306797", "27219064", "19481460", "35507869" ]

[ "Identification of a novel microtubule-destabilizing motif in CPAP that binds to tubulin heterodimers and inhibits microtubule assembly.", "Plk4-induced centriole biogenesis in human cells.", "PLK2 phosphorylation is critical for CPAP function in procentriole formation during the centrosome cycle.", "Molecula...

[ 2004, 2007, 2010, 2016, 2016, 2009, 2022 ]

7

[]

0

null

[ "Arcicella aurantiaca", "Eukaryota" ]

[ 1, 1370 ]

2

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 11, 5, 1, 6 ]

4

true

Domain

CENPJ, tubulin-binding region

Tubulin-bd_CENPJ

6

IPR058030

58,030

TRIM8/14/16/25/29/45/65, coiled-coil region

TRIM8/14/16/25/29/45/65_CC

Domain

24,356

false

This entry represents a long helical region connecting domains in TRIM proteins such as TRIM16, TRIM29, TRIM25, TRIM 65, TRIM47, TRIM8 and TRIM14. Many members of this entry act as E3 ubiquitin-protein ligases [ , , ]. The TRIM Coiled-Coil (TRIM_CC) domain is a long helical region found in Tripartite Motif (TRIM) prote...

[]

0

[ "PFAM" ]

[ "PF25600" ]

[ "TRIM_CC" ]

[ 24356 ]

1

[ "EC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "2.3.2.27", "PWY-7511", "R-HSA-1169408", "R-HSA-168928", "R-HSA-5656169", "R-HSA-5689896", "R-HSA-877300", "R-HSA-918233", "R-HSA-933541", "R-HSA-933542", "R-HSA-933543", "R-HSA-936440", "R-HSA-9692916", "R-HSA-9705671", "R-HSA-9833109", "R-HSA-9833110", "R-HSA-9833482", "R-HSA-990...

[ "EC:2.3.2.27", "METACYC:PWY-7511", "REACTOME:R-HSA-1169408", "REACTOME:R-HSA-168928", "REACTOME:R-HSA-5656169", "REACTOME:R-HSA-5689896", "REACTOME:R-HSA-877300", "REACTOME:R-HSA-918233", "REACTOME:R-HSA-933541", "REACTOME:R-HSA-933542", "REACTOME:R-HSA-933543", "REACTOME:R-HSA-936440", "REA...

22

[ "4cfg", "4ltb", "5nt1", "5nt2", "6fln", "8sde" ]

6

[ "PUB00107839", "PUB00130668", "PUB00160709", "PUB00160906", "PUB00160907" ]

[ "23630998", "22629402", "31406497", "27981609", "28747347" ]

[ "TRIM proteins as RING finger E3 ubiquitin ligases.", "TRIM16 acts as an E3 ubiquitin ligase and can heterodimerize with other TRIM family members.", "Tripartite motif proteins: an emerging antiviral protein family.", "The E3 ligase tripartite motif 8 targets TAK1 to promote insulin resistance and steatohepat...

[ 2012, 2012, 2019, 2017, 2017 ]

5

[]

0

null

[ "Eukaryota" ]

[ 24356 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 331, 35, 26, 28 ]

4

true

Domain

TRIM8/14/16/25/29/45/65, coiled-coil region

TRIM8/14/16/25/29/45/65_CC

9

IPR058031

58,031

NorR-like, AAA+ ATPase lid domain

AAA_lid_NorR

Domain

147,579

false

This entry represents the AAA+ ATPase lid domain, often found C-terminal to the RNA polymerase sigma factor 54 interaction domain in bacterial transcription factors, including NorR and NtrC. Some bacterial regulatory proteins activate the expression of genes from promoters recognised by core RNA polymerase associated w...

[]

0

[ "PFAM" ]

[ "PF25601" ]

[ "AAA_lid_14" ]

[ 147579 ]

1

[]

0

[ "1ny5", "1ny6", "1ojl", "2bjv", "2bjw", "2c96", "2c98", "2c99", "2c9c", "2vii", "3dzd", "3m0e", "4bs1", "4bt0", "4bt1", "4l4u", "4ly6", "4lzz", "4qhs", "4qht", "4qnm", "4qnr", "4qos", "5ep0", "5ep1", "5ep2", "5ep3", "5ep4", "5exp", "5exs", "5ext", "5exx"...

62

[ "PUB00000103", "PUB00001221", "PUB00002228", "PUB00004389", "PUB00108190", "PUB00160559", "PUB00160560" ]

[ "2694934", "1534752", "8407777", "2041769", "28088479", "25688103", "32483114" ]

[ "Prokaryotic signal transduction mediated by sensor and regulator protein pairs.", "The prokaryotic enhancer binding protein NTRC has an ATPase activity which is phosphorylation and DNA dependent.", "The sigma 54 bacterial enhancer-binding protein family: mechanism of action and phylogenetic relationship of the...

[ 1989, 1992, 1993, 1991, 2017, 2015, 2020 ]

7

[]

0

null

[ "Bacteria", "Eukaryota", "Fervidicoccus fontis", "Siphoviridae sp. ctKRD15", "unclassified sequences" ]

[ 145502, 273, 1, 1, 1802 ]

5

[ "Escherichia coli (strain K12)" ]

[ 13 ]

1

true

Domain

NorR-like, AAA+ ATPase lid domain

AAA_lid_NorR

2

IPR058032

58,032

Plastid division protein CDP1-like, 1st alpha solenoid domain

CDP1-like_a_solenoid_1

Domain

1,784

false

This entry represents the first α-helical solenoid domain at the N-terminal of Plastid division protein CDP1, chloroplastic and Protein ACCUMULATION AND REPLICATION OF CHLOROPLASTS 6, chloroplastic (ARC6) from Arabidopsis thaliana, and similar sequences mainly from plants and cyanobacteria. This domain is usually found...

[]

0

[ "PFAM" ]

[ "PF25515" ]

[ "Arm_PDR" ]

[ 1784 ]

1

[]

0

[]

0

[ "PUB00015440", "PUB00096838", "PUB00096839", "PUB00160083", "PUB00160084", "PUB00160085" ]

[ "9770300", "26452626", "26527658", "23936263", "28248291", "28984364" ]

[ "The armadillo family of structural proteins.", "Crystal structure of a conserved domain in the intermembrane space region of the plastid division protein ARC6.", "Roles of Arabidopsis PARC6 in Coordination of the Chloroplast Division Complex and Negative Regulation of FtsZ Assembly.", "The chloroplast min sy...

[ 1999, 2016, 2016, 2013, 2017, 2018 ]

6

[]

0

null

[ "Cyanobacteriota", "Eukaryota" ]

[ 364, 1420 ]

2

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 11, 6, 9 ]

3

true

Domain

Plastid division protein CDP1-like, 1st alpha solenoid domain

CDP1-like_a_solenoid_1

6

IPR058033

58,033

Tubulin-folding cofactor D, ARM repeats

ARM_TBCD_2nd

Domain

5,321

false

This is the second region of armadillo (ARM)-like repeats found in human Tubulin-specific chaperone D (TBCD) and its homologues in eukaryotes. It is found next to . Tubulin-folding cofactor D (TBCD) can interact with beta tubulin, which is regulated via its interaction with ARL2 (ADP ribosylation factor-like protein 2)...

[]

0

[ "PFAM" ]

[ "PF25767" ]

[ "ARM_TBCD_2nd" ]

[ 5321 ]

1

[ "REACTOME" ]

[ "R-HSA-389977" ]

[ "REACTOME:R-HSA-389977" ]

1

[ "9m1i", "9m1j", "9m1k", "9m1l", "9m1m", "9m1n" ]

6

[ "PUB00010143", "PUB00053749", "PUB00065872", "PUB00077898", "PUB00077911", "PUB00154251", "PUB00160564", "PUB00160565", "PUB00160566", "PUB00160567", "PUB00160568" ]

[ "10831612", "10722852", "22118460", "23973072", "26208336", "31036638", "26182430", "25290767", "30718544", "35414142", "20887736" ]

[ "ADP ribosylation factor-like protein 2 (Arl2) regulates the interaction of tubulin-folding cofactor D with native tubulin.", "Tubulin folding cofactor D is a microtubule destabilizing protein.", "The molecular basis of CRL4DDB2/CSA ubiquitin ligase architecture, targeting, and activation.", "Tubulin-specific...

[ 2000, 2000, 2011, 2013, 2015, 2019, 2015, 2014, 2019, 2022, 2010 ]

11

[]

0

null

[ "Eukaryota", "bioreactor metagenome" ]

[ 5320, 1 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 6, 1, 2, 1, 20, 3, 1, 4, 5, 1, 1, 18 ]

12

true

Domain

Tubulin-folding cofactor D, ARM repeats

ARM_TBCD_2nd

3

IPR058034

58,034

Putative surface-exposed virulence protein BigA, beta-sandwich domain

BigA_beta

Domain

2,888

false

This entry represents a β-sandwich domain found in Putative surface-exposed virulence protein BigA from Salmonella typhimurium and similar proteins from proteobacteria. This domain is found adjacent to the C-terminal autotransporter domain ( ) and is part of the passenger domain that is transported through the autotran...

[]

0

[ "PFAM" ]

[ "PF25783" ]

[ "BigA_beta" ]

[ 2888 ]

1

[]

0

[]

0

[ "PUB00008435" ]

[ "9778731" ]

[ "The great escape: structure and function of the autotransporter proteins." ]

[ 1998 ]

1

[]

0

null

[ "Bacteria", "Opisthokonta" ]

[ 2885, 3 ]

2

[]

0

true

Domain

Putative surface-exposed virulence protein BigA, beta-sandwich domain

BigA_beta

1

IPR058035

58,035

BigA/YdbA-like, N-terminal domain

BigA/YdbA-like_N

Domain

2,746

false

This entry represents the N-terminal 8-stranded β-barrel domain found in the BigA family of bacterial virulence proteins and related proteins such as YdbA from Escherichia coli. This domain is located N-terminal to the repetitive region in BigA proteins and is part of the passenger domain that is transported through th...

[]

0

[ "PFAM" ]

[ "PF25784" ]

[ "BigA_N" ]

[ 2746 ]

1

[]

0

[]

0

[ "PUB00008435" ]

[ "9778731" ]

[ "The great escape: structure and function of the autotransporter proteins." ]

[ 1998 ]

1

[]

0

null

[ "Pseudomonadota" ]

[ 2746 ]

1

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Domain

BigA/YdbA-like, N-terminal domain

BigA/YdbA-like_N

8

IPR058036

58,036

Probable ATP-binding protein BrxC, 4th six-stranded beta-sheet domain

BREX_BrxC_4th

Domain

1,465

false

This entry represents the 4th domain of the BrxC protein from the BREX (bacteriophage exclusion) system. This α/β domain contains a distinctive six-stranded β-sheet with α-helices. It is predicted to be the 4th of 8 domains in the full-length BrxC protein. BrxC is a P-loop-containing, probable ATPase associated with ty...

[]

0

[ "PFAM" ]

[ "PF25796" ]

[ "BREX_BrxC_4th" ]

[ 1465 ]

1

[]

0

[]

0

[ "PUB00093365" ]

[ "25452498" ]

[ "BREX is a novel phage resistance system widespread in microbial genomes." ]

[ 2015 ]

1

[]

0

null

[ "Bacteria", "IncJ plasmid R391", "Methanobacteriota", "Pleodorina starrii", "Siphoviridae sp. ctSA812", "metagenomes" ]

[ 1394, 1, 59, 1, 1, 9 ]

6

[]

0

true

Domain

Probable ATP-binding protein BrxC, 4th six-stranded beta-sheet domain

BREX_BrxC_4th

4

IPR058037

58,037

Probable ATP-binding protein BrxC, alpha-helical domain

BREX_BrxC_helical

Domain

1,439

false

This entry represents the small α-helical domain of the BrxC protein from the BREX (bacteriophage exclusion) system. This domain is predicted to be the 6th of 8 domains in the full-length BrxC protein. This small α-helical domain may be involved in protein-protein interactions within the BREX complex or contribute to t...

[]

0

[ "PFAM" ]

[ "PF25792" ]

[ "BREX_BrxC_helical" ]

[ 1439 ]

1

[]

0

[]

0

[ "PUB00093365" ]

[ "25452498" ]

[ "BREX is a novel phage resistance system widespread in microbial genomes." ]

[ 2015 ]

1

[]

0

null

[ "Bacteria", "IncJ plasmid R391", "Methanobacteriota", "Pleodorina starrii", "Siphoviridae sp. ctSA812", "metagenomes" ]

[ 1371, 1, 56, 1, 1, 9 ]

6

[]

0

true

Domain

Probable ATP-binding protein BrxC, alpha-helical domain

BREX_BrxC_helical

5

IPR058039

58,039

At3g05675-like, ankyrin-like domain

At3g05675-like_ankyrin

Domain

4,061

false

This entry describes a region of ankyrin-like repeats found at the C-terminal of BTB/POZ containing proteins mostly from plants, including At3g05675, At2g13690, At1g63850, At5g60050 and At3g50780 from Arabidopsis thaliana. At3g05675 and related proteins may act as a substrate-specific adapter of an E3 ubiquitin-protein...

[]

0

[ "PFAM" ]

[ "PF25553" ]

[ "BTB-POZ_ANK-like" ]

[ 4061 ]

1

[]

0

[]

0

[ "PUB00033542", "PUB00033553" ]

[ "13679922", "15772280" ]

[ "BTB proteins are substrate-specific adaptors in an SCF-like modular ubiquitin ligase containing CUL-3.", "Arabidopsis has two redundant Cullin3 proteins that are essential for embryo development and that interact with RBX1 and BTB proteins to form multisubunit E3 ubiquitin ligase complexes in vivo." ]

[ 2003, 2005 ]

2

[]

0

null

[ "Streptophytina" ]

[ 4061 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 30, 28, 41 ]

3

true

Domain

At3g05675-like, ankyrin-like domain

At3g05675-like_ankyrin

5

IPR058040

58,040

Baseplate wedge 3 tail fiber network component

BW3TFN

Family

394

false

This entry represents the Baseplate Wedge 3 Tail Fibre Network (BW3TFN) component found in bacteriophage A511 and related phages. The protein forms dimers that constitute an essential part of the bacteriophage tail fibre structure. The BW3TFN protein (gp105 in phage A511, ) is located in the proximal part of the tail f...

[]

0

[ "PFAM" ]

[ "PF25691" ]

[ "BW3TFN" ]

[ 394 ]

1

[]

0

[ "6hhk", "9euf", "9eui", "9euj", "9fko" ]

5

[ "PUB00160590" ]

[ "30606715" ]

[ "Structure and transformation of bacteriophage A511 baseplate and tail upon infection of Listeria cells." ]

[ 2019 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "Viruses", "viral metagenome" ]

[ 199, 9, 185, 1 ]

4

[]

0

true

Family

Baseplate wedge 3 tail fiber network component

BW3TFN

3

IPR058041

58,041

Filamentous dsRNA virus capsid protein

CcFV1_CP

Family

30

false

This entry represents the capsid protein (CP, P4) of Colletotrichum camelliae filamentous virus 1 (CcFV-1), a unique dsRNA virus that forms filamentous particles rather than the typical isometric particles found in other dsRNA viruses. The CcFV-1 CP is encoded by ORF4 on dsRNA4 and has a molecular mass of approximately...

[]

0

[ "PFAM" ]

[ "PF25660" ]

[ "CcFV1_CP" ]

[ 30 ]

1

[]

0

[]

0

[ "PUB00160941" ]

[ "28761042" ]

[ "A dsRNA virus with filamentous viral particles." ]

[ 2017 ]

1

[]

0

null

[ "Riboviria" ]

[ 30 ]

1

[]

0

true

Family

Filamentous dsRNA virus capsid protein

CcFV1_CP

5

IPR058043

58,043

Chimallin

Family

67

false

The Phikzvirus chimallin family consists of proteins that self-assemble to form a protective proteinaceous shell around viral DNA. This shell compartmentalises proteins and DNA during viral infection, creating a micrometre-scale compartment with narrow pores. It serves as the site of viral replication, where proteins i...

[]

0

[ "PFAM" ]

[ "PF25677" ]

[ "Chimallin_Phikzvirus" ]

[ 67 ]

1

[]

0

[ "7sqq", "7sqr", "7sqs", "7sqt", "7squ", "7sqv", "8fne", "8fv5", "8igg" ]

9

[ "PUB00154309", "PUB00160598", "PUB00160599" ]

[ "28813669", "37138628", "35922510" ]

[ "The Phage Nucleus and Tubulin Spindle Are Conserved among Large Pseudomonas Phages.", "Structural studies of the nucleus-like assembly of jumbo bacteriophage 201φ2-1.", "Architecture and self-assembly of the jumbo bacteriophage nuclear shell." ]

[ 2017, 2023, 2022 ]

3

[]

0

null

[ "Salmonella muenchen", "Viruses", "Wickerhamomyces mucosus" ]

[ 1, 65, 1 ]

3

[]

0

true

Family

Chimallin

6

IPR058044

58,044

Metallo-beta-lactamase VIM-1/2/7

VIM-1/2/7

Family

230

false

This protein family includes the metallo-beta-lactamases VIM-1/7 from Pseudomonas aeruginosa, VIM-2 from Escherichia coli, and similar VIM (Verona integron-encoded metallo-beta-lactamase)-type proteins from gammaproteobacteria. These proteins are class B1 beta-lactamases that confer resistance to the beta-lactam antibi...

[ "GO:0008800" ]

[ "beta-lactamase activity" ]

[ "molecular_function" ]

1

[ "NCBIFAM" ]

[ "NF012100" ]

[ "blaVIM" ]

[ 230 ]

1

[ "EC" ]

[ "3.5.2.6" ]

[ "EC:3.5.2.6" ]

1

[ "1ko2", "1ko3", "2whg", "2wrs", "2y87", "2y8a", "2y8b", "2yz3", "4bz3", "4c1d", "4c1e", "4d1t", "4d1u", "4d1v", "4d1w", "4fr7", "4fsb", "4nq2", "4pvo", "4pvt", "4ua4", "4uwo", "4uwp", "4uwr", "4uws", "5a87", "5acu", "5acv", "5acw", "5acx", "5fqc", "5k48"...

201

[ "PUB00087024", "PUB00135074", "PUB00135349", "PUB00135350", "PUB00135351", "PUB00135352", "PUB00159075", "PUB00160909", "PUB00160910", "PUB00160911", "PUB00160912", "PUB00160913", "PUB00160914", "PUB00160915", "PUB00160916" ]

[ "17597585", "15980349", "19917750", "21521413", "25601024", "25825035", "10390207", "15561840", "28971872", "32229489", "20498317", "24965651", "31744917", "14693560", "18559652" ]

[ "Metallo-beta-lactamases (classification, activity, genetic organization, structure, zinc coordination) and their superfamily.", "Structure-based phylogeny of the metallo-beta-lactamases.", "VIM-19, a metallo-beta-lactamase with increased carbapenemase activity from Escherichia coli and Klebsiella pneumoniae.",...

[ 2007, 2005, 2010, 2011, 2015, 2015, 1999, 2004, 2017, 2020, 2010, 2014, 2019, 2004, 2008 ]

15

[ "IPR058199" ]

[]

1

0

1

[ "Pseudomonadati" ]

[ 230 ]

1

[]

0

true

Family

Metallo-beta-lactamase VIM-1/2/7

VIM-1/2/7

9

IPR058045

58,045

UL148C

Family

21

false

This entry represents a family of viral membrane proteins UL148C found in Human cytomegalovirus (HCMV). UL148C is predicted to contain two transmembrane helices and is located in the host cell membrane. The specific function of this protein remains to be determined.

[]

0

[ "PFAM" ]

[ "PF25750" ]

[ "CMV_UL148C" ]

[ 21 ]

1

[]

0

[]

0

[ "PUB00160600" ]

[ "17049918" ]

[ "Polymorphisms of human cytomegalovirus UL148A, UL148B, UL148C, UL148D genes in clinical strains." ]

[ 2006 ]

1

[]

0

null

[ "Cytomegalovirus" ]

[ 21 ]

1

[]

0

true

Family

UL148C

3

IPR058046

58,046

Transcriptional regulator UL34

UL34

Family

100

false

This entry represents the UL34 protein family found in herpesvirales. UL34 acts as a transcriptional repressor of the US3 gene expression through a specific DNA sequence named the transcriptional repressive element (tre). The protein is localised to the host nucleus during viral infection [ ]. Structure prediction sugg...

[]

0

[ "PFAM" ]

[ "PF25722" ]

[ "CMV_UL34" ]

[ 100 ]

1

[ "REACTOME" ]

[ "R-HSA-9609690" ]

[ "REACTOME:R-HSA-9609690" ]

1

[]

0

[ "PUB00160934" ]

[ "11390608" ]

[ "Identification of a novel transcriptional repressor encoded by human cytomegalovirus." ]

[ 2001 ]

1

[]

0

null

[ "Herpesvirales" ]

[ 100 ]

1

[]

0

true

Family

Transcriptional regulator UL34

UL34

1

IPR058047

58,047

Carbamoyl phosphate synthase, preATP-grasp domain

CPSase_preATP-grasp

Domain

58,248

false

This entry represents the preATP-grasp domain found twice in Carbamoyl phosphate synthase proteins. This domain is found associated with . Carbamoyl phosphate synthase (CPSase) is a heterodimeric enzyme composed of a small and a large subunit (with the exception of CPSase III, see below). CPSase catalyses the synthesis...

[]

0

[ "PFAM" ]

[ "PF25596" ]

[ "CPSase_L_D1" ]

[ 58248 ]

1

[ "EC", "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "6.3.4.16", "6.3.5.5", "PWY-4984", "PWY-5154", "PWY-5686", "PWY-7400", "PWY-7790", "PWY-7791", "R-CEL-500753", "R-DDI-500753", "R-DME-500753", "R-HSA-500753", "R-HSA-70635", "R-MMU-500753", "R-MMU-70635", "R-RNO-70635", "R-SCE-500753", "R-SCE-70635", "R-SPO-500753", "R-SPO-7063...

[ "EC:6.3.4.16", "EC:6.3.5.5", "METACYC:PWY-4984", "METACYC:PWY-5154", "METACYC:PWY-5686", "METACYC:PWY-7400", "METACYC:PWY-7790", "METACYC:PWY-7791", "REACTOME:R-CEL-500753", "REACTOME:R-DDI-500753", "REACTOME:R-DME-500753", "REACTOME:R-HSA-500753", "REACTOME:R-HSA-70635", "REACTOME:R-MMU-5...

20

[ "1a9x", "1bxr", "1c30", "1c3o", "1ce8", "1cs0", "1jdb", "1kee", "1m6v", "1t36", "5dot", "5dou", "6uel", "6w2j" ]

14

[ "PUB00006448", "PUB00007868", "PUB00042596", "PUB00042597", "PUB00042598", "PUB00042599", "PUB00042600", "PUB00042601", "PUB00042602" ]

[ "10387030", "10089390", "17397987", "11212301", "8916922", "12379099", "7907330", "17451989", "7932737" ]

[ "The amidotransferase family of enzymes: molecular machines for the production and delivery of ammonia.", "The structure of carbamoyl phosphate synthetase determined to 2.1 A resolution.", "cyclicAMP and glucocorticoid responsiveness of the rat carbamoylphosphate synthetase gene requires the interplay of upstre...

[ 1999, 1999, 2007, 1999, 1996, 2002, 1994, 2007, 1994 ]

9

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 889, 27156, 29442, 3, 758 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus",...

[ 5, 1, 7, 3, 1, 13, 7, 2, 1, 12, 2, 2, 6 ]

13

true

Domain

Carbamoyl phosphate synthase, preATP-grasp domain

CPSase_preATP-grasp

7

IPR058048

58,048

Auxiliary capsid protein, crAss001

AuxCP

Family

22

false

This entry represents the auxiliary capsid protein found in Bacteroides phage crAss001. This protein forms an outer layer on the major capsid protein protrusions and is present in 535 copies in the virion. The central region (amino acids 75-237) is structurally similar to Helicobacter pylori flagellar cap protein FliD ...

[]

0

[ "PFAM" ]

[ "PF25650" ]

[ "crAss_AuxCP" ]

[ 22 ]

1

[]

0

[ "7qof", "7qoh", "7qoi", "8ckb" ]

4

[]

0

[]

0

null

[ "Caudoviricetes" ]

[ 22 ]

1

[]

0

true

Family

Auxiliary capsid protein, crAss001

AuxCP

9

IPR058049

58,049

Cargo protein 1, compact domain

crAss_CARG1

Domain

23

false

This entry represents the compact domain of cargo protein 1 (C1) found in crassviruses. This protein is unique in that different portions of it are found in both the capsid and the tail of the virion. This domain is bound to the portal protein wing domain inside the capsid, with 12 such segments interdigitating with wi...

[]

0

[ "PFAM" ]

[ "PF25725" ]

[ "crAss_CARG1" ]

[ 23 ]

1

[]

0

[ "7qog", "7qoi", "7qoj", "7qol", "8ckb" ]

5

[ "PUB00155591" ]

[ "37138077" ]

[ "Structural atlas of a human gut crassvirus." ]

[ 2023 ]

1

[]

0

null

[ "Caudoviricetes", "Cylicocyclus nassatus" ]

[ 22, 1 ]

2

[]

0

true

Domain

Cargo protein 1, compact domain

crAss_CARG1

7

IPR058050

58,050

Cargo protein 2

CARGO2

Family

23

false

This entry represents cargo protein 2, a protein stored in high quantity within bacteriophage capsids. This protein likely plays an important role during the phage infection process, particularly during genome ejection. Cargo proteins are packaged inside the viral capsid and are delivered to the host cell during infect...

[]

0

[ "PFAM" ]

[ "PF25712" ]

[ "crAss_CARGO2" ]

[ 23 ]

1

[]

0

[]

0

[ "PUB00155591" ]

[ "37138077" ]

[ "Structural atlas of a human gut crassvirus." ]

[ 2023 ]

1

[]

0

null

[ "Bacteroides xylanisolvens", "Caudoviricetes", "Cylicocyclus nassatus" ]

[ 1, 21, 1 ]

3

[]

0

true

Family

Cargo protein 2

CARGO2

3

IPR058051

58,051

Synoviolin-like, RING finger

Znf_RING_synoviolin

Domain

4,581

false

This entry represents the C3H2C2-type RING-H2 finger in Synoviolin proteins and Hrd1p, its orthologue in fungi and plants. Synoviolin, also known as synovial apoptosis inhibitor 1 (Syvn1), Hrd1, or Der3, is an endoplasmic reticulum (ER)-anchoring E3 ubiquitin ligase that functions as a suppressor of ER stress-induced a...

[]

0

[ "CDD" ]

[ "cd16479" ]

[ "RING-H2_synoviolin" ]

[ 4581 ]

1

[ "EC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "2.3.2.27", "PWY-7511", "R-CEL-5358346", "R-DME-5358346", "R-DRE-5358346", "R-HSA-381038", "R-HSA-5358346", "R-HSA-5362768", "R-HSA-901032", "R-MMU-5358346", "R-SPO-5358346" ]

[ "EC:2.3.2.27", "METACYC:PWY-7511", "REACTOME:R-CEL-5358346", "REACTOME:R-DME-5358346", "REACTOME:R-DRE-5358346", "REACTOME:R-HSA-381038", "REACTOME:R-HSA-5358346", "REACTOME:R-HSA-5362768", "REACTOME:R-HSA-901032", "REACTOME:R-MMU-5358346", "REACTOME:R-SPO-5358346" ]

11

[ "5v6p", "6a3z", "6f98", "6vjy", "6vjz", "6vk0", "6vk1", "8kes", "8ket", "8kev", "9lwu", "9og0" ]

12

[ "PUB00045240", "PUB00076836", "PUB00090052", "PUB00098136", "PUB00098137", "PUB00114901", "PUB00138034", "PUB00138035", "PUB00138036", "PUB00138037", "PUB00138038", "PUB00138039", "PUB00138040", "PUB00138041", "PUB00138042", "PUB00138043", "PUB00138044", "PUB00138045", "PUB001380...

[ "18656546", "17170702", "16289116", "18502753", "18264092", "24275569", "12459480", "12646171", "12975321", "14593114", "16186510", "17059562", "16847254", "17141218", "25806530", "25698262", "23129766", "22992760", "20976214", "19725872", "18369366", "18235538", "1678616...

[ "Ubxd1 is a novel co-factor of the human p97 ATPase.", "Cytoplasmic destruction of p53 by the endoplasmic reticulum-resident ubiquitin ligase 'Synoviolin'.", "The ubiquitin-domain protein HERP forms a complex with components of the endoplasmic reticulum associated degradation pathway.", "Human XTP3-B forms an...

[ 2008, 2007, 2005, 2008, 2008, 2014, 2002, 2003, 2003, 2004, 2005, 2006, 2006, 2007, 2015, 2015, 2012, 2012, 2010, 2009, 2008, 2008, 2006, 2005 ]

24

[ "IPR001841" ]

[]

1

0

1

[ "Eukaryota" ]

[ 4581 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 12, 1, 2, 3, 3, 4, 1, 2, 5, 1, 1, 24 ]

12

true

Domain

Synoviolin-like, RING finger

Znf_RING_synoviolin

8

IPR058053

58,053

RamC, C-terminal domain

RamC_C

Domain

2,582

false

This domain is found at the C-terminal end of RamC and similar proteins mainly found in actinomycetes. Probable SapB synthase from Streptomyces coelicolor (RamC) is required for aerial hyphae formation [ , , ]. It is probably involved in processing the precursor of SapB to its mature form. It shows an α-β configuration...

[]

0

[ "CDD" ]

[ "cd04791" ]

[ "LanC_SerThrkinase" ]

[ 2582 ]

1

[]

0

[ "8car", "8cav", "8sam", "8sao", "8sap", "8w7a", "8w7j", "8w7l", "8wgo", "9ugq" ]

10

[ "PUB00040886", "PUB00081567", "PUB00081568", "PUB00081569", "PUB00081570", "PUB00081571", "PUB00160859", "PUB00160860", "PUB00160861" ]

[ "16527981", "17046525", "16118063", "15638769", "15450492", "11348686", "12100547", "12169618", "12453210" ]

[ "Structure and mechanism of the lantibiotic cyclase involved in nisin biosynthesis.", "Lantibiotics: insight and foresight for new paradigm.", "New developments in lantibiotic biosynthesis and mode of action.", "Bacterial lantibiotics: strategies to improve therapeutic potential.", "Post-translational modif...

[ 2006, 2006, 2005, 2005, 2004, 2001, 2002, 2002, 2002 ]

9

[]

0

null

[ "Bacteria", "Russula earlei", "mine drainage metagenome" ]

[ 2579, 1, 2 ]

3

[]

0

true

Domain

RamC, C-terminal domain

RamC_C

3

IPR058054

58,054

PHD finger protein MALE STERILITY 1-like, Zinc finger

Znf_MS1-like

Domain

2,066

false

This entry represents the PHD (homeodomain) zinc finger domain in MS1, PTC1 and similar proteins found in plants. PHD finger protein MALE STERILITY 1 (MS1) is a nuclear transcriptional activator essential for anther and post-meiotic pollen development and maturation. It plays a key role in tapetal development, pollen w...

[]

0

[ "CDD" ]

[ "cd15556" ]

[ "PHD_MMD1_like" ]

[ 2066 ]

1

[]

0

[]

0

[ "PUB00085380", "PUB00134260", "PUB00134261", "PUB00134262", "PUB00134263", "PUB00134264", "PUB00134265", "PUB00160826", "PUB00160943" ]

[ "21037105", "18032630", "18032629", "14573517", "12782723", "12461128", "11696184", "7824655", "21515697" ]

[ "Arabidopsis SET DOMAIN GROUP2 is required for H3K4 trimethylation and is crucial for both sporophyte and gametophyte development.", "Arabidopsis MALE STERILITY1 encodes a PHD-type transcription factor and regulates pollen and tapetum development.", "MALE STERILITY1 is required for tapetal development and polle...

[ 2010, 2007, 2007, 2003, 2003, 2002, 2001, 1994, 2011 ]

9

[ "IPR019787" ]

[]

1

0

1

[ "Eukaryota" ]

[ 2066 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 19, 10, 12 ]

3

true

Domain

PHD finger protein MALE STERILITY 1-like, Zinc finger

Znf_MS1-like

2

IPR058055

58,055

PA-PLA1

Family

10,648

false

This entry includes PA-PLA1 proteins, including SEC23-interacting protein (Sec23ip), Triacylglycerol hydrolase DDHD2 (DDHD2) and Phospholipase DDHD1, which are PA-PLA1 proteins in mammals. This entry also includes the homologue in Saccharomyces cerevisiae and putative homologues in Schizosaccharomyces pombe, Caenorhabd...

[]

0

[ "PANTHER" ]

[ "PTHR23509" ]

[ "" ]

[ 10648 ]

1

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "3.1.1", "R-HSA-1483166", "R-HSA-204005", "R-MMU-1483166", "R-MMU-204005", "R-SCE-1483166", "R-SCE-1483226", "R-SCE-204005", "R-SPO-1483166", "R-SPO-1483226", "R-SPO-204005" ]

[ "EC:3.1.1", "REACTOME:R-HSA-1483166", "REACTOME:R-HSA-204005", "REACTOME:R-MMU-1483166", "REACTOME:R-MMU-204005", "REACTOME:R-SCE-1483166", "REACTOME:R-SCE-1483226", "REACTOME:R-SCE-204005", "REACTOME:R-SPO-1483166", "REACTOME:R-SPO-1483226", "REACTOME:R-SPO-204005" ]

11

[]

0

[ "PUB00126412", "PUB00126413", "PUB00160931", "PUB00160933", "PUB00160935", "PUB00160936", "PUB00160954" ]

[ "10400679", "15623529", "24599962", "22922100", "29278326", "37832604", "31024579" ]

[ "p125 is a novel mammalian Sec23p-interacting protein with structural similarity to phospholipid-modifying proteins.", "p125 is localized in endoplasmic reticulum exit sites and involved in their organization.", "Phosphatidic acid (PA)-preferring phospholipase A1 regulates mitochondrial dynamics.", "Roles of ...

[ 1999, 2005, 2014, 2012, 2018, 2023, 2019 ]

7

[]

0

null

[ "Bacillati", "Eukaryota" ]

[ 9, 10639 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 4, 1, 15, 4, 27, 24, 2, 5, 15, 1, 2, 34 ]

12

true

Family

PA-PLA1

1

IPR058056

58,056

TANC1/2-like, winged helix domain

WH_TANC1/2

Domain

8,309

false

This presumed winged helix-turn-helix domain is found in Protein TANC1, TANC2 and similar proteins mainly found in animals. This domain is often found associated to a long region of ankyrin repeats ( ). TANC proteins function as scaffolding components in the postsynaptic density and dendritic spines. These proteins are...

[]

0

[ "PFAM" ]

[ "PF25521" ]

[ "WHD_TANC1" ]

[ 8309 ]

1

[]

0

[]

0

[ "PUB00160897", "PUB00160898", "PUB00160899" ]

[ "21068316", "22182840", "38092135" ]

[ "Regulation of dendritic spines, spatial memory, and embryonic development by the TANC family of PSD-95-interacting proteins.", "Drosophila and mammalian models uncover a role for the myoblast fusion gene TANC1 in rhabdomyosarcoma.", "Tanc1/2 TPR domain interacts with Myo18a C-terminus and undergoes liquid-liqu...

[ 2010, 2012, 2024 ]

3

[]

0

null

[ "Bacteria", "Eukaryota", "Methanomicrobia" ]

[ 14, 8293, 2 ]

3

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 44, 14, 6, 8, 12 ]

5

true

Domain

TANC1/2-like, winged helix domain

WH_TANC1/2

1

IPR058057

58,057

Lipoprotein BBH37-like

BBH37-like

Family

158

false

This entry represents BBH37 from Borrelia burgdorferi ( ) and related proteins from Spirochaetales. Many members posses a lipid attachment site. Proteins in this entry have a domain ( ) that folds into a helical bundle ( ).

[]

0

[ "NCBIFAM" ]

[ "NF033721" ]

[ "P12_lipo" ]

[ 158 ]

1

[]

0

[ "8cqn", "8cqo", "8s2f", "8s2p" ]

4

[ "PUB00105271" ]

[ "19936201" ]

[ "Stem loop sequences specific to transposable element IS605 are found linked to lipoprotein genes in Borrelia plasmids." ]

[ 2009 ]

1

[]

0

null

[ "Borreliaceae" ]

[ 158 ]

1

[]

0

true

Family

Lipoprotein BBH37-like

BBH37-like

5