interpro_id string | interpro_numeric_id int64 | name string | short_name string | entry_type string | protein_count int64 | is_llm bool | is_llm_reviewed bool | abstract string | go_ids list | go_terms list | go_categories list | go_count int64 | member_databases list | member_accessions list | member_names list | member_protein_counts list | member_count int64 | external_databases list | external_accessions list | external_xrefs list | external_xref_count int64 | pdb_ids list | structure_count int64 | publication_ids list | pubmed_ids list | publication_titles list | publication_years list | publication_count int64 | parent_ids list | child_ids list | parent_count int64 | child_count int64 | tree_depth float64 | taxonomy_names list | taxonomy_protein_counts list | taxonomy_count int64 | key_species_names list | key_species_protein_counts list | key_species_count int64 | in_entry_list bool | entry_list_type string | entry_list_name string | names_dat_name string | short_names_dat_name string | split_bucket int64 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
IPR058855 | 58,855 | RGS1/SST2-like, Fungal-Differentiation Regulator domain | RGS1/SST2-like_Fungal-DR | Domain | 2,073 | false | false | This entry represents the Fungal-Differentiation Regulator (Fungal-DR) domain, a winged helix domain found in fungal regulators of G-protein signalling (RGS) that regulate differentiation pathways, such as Aspergillus nidulans FlbA, Schizosaccharomyces pombe Rgs1 and Saccharomyces cerevisiae Sst2, where it plays a crit... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25889"
] | [
"WHD_Fungal_DR"
] | [
2073
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-SCE-416476",
"R-SCE-418594",
"R-SCE-418597",
"R-SPO-416476",
"R-SPO-418594",
"R-SPO-418597"
] | [
"REACTOME:R-SCE-416476",
"REACTOME:R-SCE-418594",
"REACTOME:R-SCE-418597",
"REACTOME:R-SPO-416476",
"REACTOME:R-SPO-418594",
"REACTOME:R-SPO-418597"
] | 6 | [] | 0 | [
"PUB00120935"
] | [
"11554925"
] | [
"The RGS domain-containing fission yeast protein, Rgs1p, regulates pheromone signalling and is required for mating."
] | [
2001
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
2073
] | 1 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
2,
1,
1
] | 3 | true | Domain | RGS1/SST2-like, Fungal-Differentiation Regulator domain | RGS1/SST2-like, Fungal-Differentiation Regulator domain | RGS1/SST2-like_Fungal-DR | 9 |
IPR058857 | 58,857 | Adhesion G-protein coupled receptor G2/6, GAIN domain | GAIN_ADGRG2/6 | Domain | 3,212 | false | false | This presumed GAIN domain is found in human Adhesion G-protein coupled receptor G2/6 (ADGRG2/6) and similar proteins from vertebrates. This domain, which is predicted to adopt an α-β structure, is usually found associated with . ADGRG2 is an adhesion G-protein coupled receptor (aGPCR) for steroid hormones, such as dehy... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26574"
] | [
"GAIN_ADGRG2"
] | [
3212
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-DRE-9619665",
"R-HSA-9619665",
"R-MMU-9619665"
] | [
"REACTOME:R-DRE-9619665",
"REACTOME:R-HSA-9619665",
"REACTOME:R-MMU-9619665"
] | 3 | [
"6v55",
"7wui",
"7xke",
"7yp7",
"8ykd"
] | 5 | [
"PUB00137747",
"PUB00161115",
"PUB00161116",
"PUB00161242",
"PUB00161660",
"PUB00161661",
"PUB00161662",
"PUB00161663",
"PUB00161664"
] | [
"24227709",
"15367682",
"29393851",
"35982227",
"33303626",
"34234254",
"39884271",
"18391950",
"35394864"
] | [
"Gpr126 functions in Schwann cells to control differentiation and myelination via G-protein activation.",
"Targeted deletion of the epididymal receptor HE6 results in fluid dysregulation and male infertility.",
"Gq activity- and β-arrestin-1 scaffolding-mediated ADGRG2/CFTR coupling are required for male fertil... | [
2013,
2004,
2018,
2022,
2021,
2021,
2025,
2008,
2022
] | 9 | [] | [] | 0 | 0 | null | [
"Vertebrata"
] | [
3212
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
54,
6,
8,
15
] | 4 | true | Domain | Adhesion G-protein coupled receptor G2/6, GAIN domain | Adhesion G-protein coupled receptor G2/6, GAIN domain | GAIN_ADGRG2/6 | 1 |
IPR058858 | 58,858 | Halobacterial acidic protein | HacaP | Family | 150 | false | false | This entry represents a family of small, uncharacterised proteins found exclusively in extremely halophilic archaea (Halobacteria). These proteins are approximately 50-65 amino acids in length and contain a highly conserved N-terminal region with the motif MPDTK. The C-terminal region is enriched in acidic residues (as... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26396"
] | [
"HacaP"
] | [
150
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Halobacteriales"
] | [
150
] | 1 | [] | [] | 0 | true | Family | Halobacterial acidic protein | Halobacterial acidic protein | HacaP | 7 |
IPR058859 | 58,859 | R-PTP-O-like, Fn3 domain | Fn3_R-PTP-O | Domain | 1,321 | false | false | This fibronectin type-III (Fn3) domain is found in human Receptor-type tyrosine-protein phosphatase O (R-PTP-O), which possesses tyrosine phosphatase activity [ ]. R-PTP-O is a long protein predicted to have five tandem Fn3 domains connected to another two through an unstructured loop in the N-terminal region. This dom... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26586"
] | [
"Fn3_R-PTP-O"
] | [
1321
] | 1 | [
"REACTOME"
] | [
"R-HSA-9034015"
] | [
"REACTOME:R-HSA-9034015"
] | 1 | [] | 0 | [
"PUB00045909",
"PUB00161233"
] | [
"19167335",
"11086029"
] | [
"Large-scale structural analysis of the classical human protein tyrosine phosphatome.",
"Altered podocyte structure in GLEPP1 (Ptpro)-deficient mice associated with hypertension and low glomerular filtration rate."
] | [
2009,
2000
] | 2 | [
"IPR003961"
] | [] | 1 | 0 | 1 | [
"Gnathostomata"
] | [
1321
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
24,
6,
4,
4
] | 4 | true | Domain | R-PTP-O-like, Fn3 domain | R-PTP-O-like, Fn3 domain | Fn3_R-PTP-O | 6 |
IPR058860 | 58,860 | Mycoplasma immunoglobulin binding protein, M2 domain | MIB_M2 | Domain | 410 | false | false | This entry represents the M2 domain of Mycoplasma immunoglobulin binding (MIB) protein. The MIB_M2 domain shares structural features with the M2 domain of Protein M from Mycoplasma genitalium, although with less conservation. This domain primarily binds to the VL domain of antibody Fab fragments and also encircles the ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26364"
] | [
"MIB_M2"
] | [
410
] | 1 | [] | [] | [] | 0 | [
"7adj",
"7adk",
"7adm"
] | 3 | [
"PUB00151017"
] | [
"33674316"
] | [
"The mycoplasma surface proteins MIB and MIP promote the dissociation of the antibody-antigen interaction."
] | [
2021
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria"
] | [
410
] | 1 | [] | [] | 0 | true | Domain | Mycoplasma immunoglobulin binding protein, M2 domain | Mycoplasma immunoglobulin binding protein, M2 domain | MIB_M2 | 7 |
IPR058861 | 58,861 | Mycoplasma immunoglobulin binding protein, arm domain | MIB_arm | Domain | 240 | false | false | This entry represents the N-terminal arm domain of the Mycoplasma immunoglobulin binding (MIB) protein. This domain contributes to the hug of death mechanism by which MIB and MIP proteins capture and cleave antibodies. The MIB arm domain is made of a globular region and connects to the MIB M1 and M2 domains via a large... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26361"
] | [
"MIB_arm"
] | [
240
] | 1 | [] | [] | [] | 0 | [
"7adj",
"7adk",
"7adm"
] | 3 | [
"PUB00151017"
] | [
"33674316"
] | [
"The mycoplasma surface proteins MIB and MIP promote the dissociation of the antibody-antigen interaction."
] | [
2021
] | 1 | [] | [] | 0 | 0 | null | [
"Mycoplasmatota"
] | [
240
] | 1 | [] | [] | 0 | true | Domain | Mycoplasma immunoglobulin binding protein, arm domain | Mycoplasma immunoglobulin binding protein, arm domain | MIB_arm | 9 |
IPR058862 | 58,862 | YgzA | YgzA | Family | 64 | false | false | This entry represents a family of small α-helical proteins related to the YgzA protein from Bacillus subtilis. The function of these proteins remains unknown. Members of this family are approximately 67 amino acids in length. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25847"
] | [
"YgzA"
] | [
64
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacillales"
] | [
64
] | 1 | [] | [] | 0 | true | Family | YgzA | YgzA | YgzA | 7 |
IPR058863 | 58,863 | Pectate disaccharide-lyase-like, central Ig-like domain | PelX-like_Ig | Domain | 549 | false | false | This entry represents the central immunoglobulin-like domain of pectate disaccharide-lyase from Dickeya chrysanthemi (PelX, ), also known as exopolygalacturonate lyase, and similar bacterial proteins. This domain is positioned between the N-terminal β-supersandwich domain and the C-terminal catalytic α-helix domain. Wh... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25850"
] | [
"PelX_Ig"
] | [
549
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00161400"
] | [
"2254266"
] | [
"Molecular cloning of the structural gene for exopolygalacturonate lyase from Erwinia chrysanthemi EC16 and characterization of the enzyme product."
] | [
1990
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"human gut metagenome"
] | [
547,
2
] | 2 | [] | [] | 0 | true | Domain | Pectate disaccharide-lyase-like, central Ig-like domain | Pectate disaccharide-lyase-like, central Ig-like domain | PelX-like_Ig | 6 |
IPR058864 | 58,864 | UBA-like domain, fungi | UBA_10 | Domain | 733 | false | false | This entry represents a UBA-like domain found in a set of fungal proteins. These proteins also contain a CUE domain , a domain related to the UBA domain. These domains may be more related to CUE domains than UBA domains. CUE domains are involved in ubiquitin binding, suggesting a potential function for this domain. Pro... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26286"
] | [
"UBA_10"
] | [
733
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"viral metagenome"
] | [
732,
1
] | 2 | [] | [] | 0 | true | Domain | UBA-like domain, fungi | UBA-like domain, fungi | UBA_10 | 2 |
IPR058865 | 58,865 | GDPGP1-like, C-terminal domain | GDPGP1_C | Domain | 3,348 | false | false | This domain is found at the C-terminal end of human GDP-D-glucose phosphorylase 1 (GDPGP1), an specific and highly efficient GDP-D-glucose phosphorylase regulating the levels of GDP-D-glucose in cells [ ]. The orthologues in A.thaliana are GDP-L-galactose phosphorylases catalysing the first reaction of the Smirnoff-Whe... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26216"
] | [
"GDPGP1_C"
] | [
3348
] | 1 | [
"EC"
] | [
"2.7.7.78"
] | [
"EC:2.7.7.78"
] | 1 | [] | 0 | [
"PUB00060530",
"PUB00070303",
"PUB00070304",
"PUB00153077",
"PUB00153078"
] | [
"21507950",
"17462988",
"18463094",
"17485667",
"17877701"
] | [
"A novel GDP-D-glucose phosphorylase involved in quality control of the nucleoside diphosphate sugar pool in Caenorhabditis elegans and mammals.",
"Arabidopsis VTC2 encodes a GDP-L-galactose phosphorylase, the last unknown enzyme in the Smirnoff-Wheeler pathway to ascorbic acid in plants.",
"A second GDP-L-gala... | [
2011,
2007,
2008,
2007,
2007
] | 5 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
386,
2938,
24
] | 3 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
5,
1,
1,
1,
1,
11,
1,
11
] | 8 | true | Domain | GDPGP1-like, C-terminal domain | GDPGP1-like, C-terminal domain | GDPGP1_C | 3 |
IPR058866 | 58,866 | GDPGP1-like, N-terminal domain | GDPGP1_N | Domain | 3,456 | false | false | This domain is found at the N-terminal end of human GDP-D-glucose phosphorylase 1 (GDPGP1), an specific and highly efficient GDP-D-glucose phosphorylase regulating the levels of GDP-D-glucose in cells [ ]. The orthologues in A.thaliana are GDP-L-galactose phosphorylases catalysing the first reaction of the Smirnoff-Whe... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26217"
] | [
"GDPGP1_N"
] | [
3456
] | 1 | [
"EC"
] | [
"2.7.7.78"
] | [
"EC:2.7.7.78"
] | 1 | [] | 0 | [
"PUB00060530",
"PUB00070303",
"PUB00070304",
"PUB00153077",
"PUB00153078"
] | [
"21507950",
"17462988",
"18463094",
"17485667",
"17877701"
] | [
"A novel GDP-D-glucose phosphorylase involved in quality control of the nucleoside diphosphate sugar pool in Caenorhabditis elegans and mammals.",
"Arabidopsis VTC2 encodes a GDP-L-galactose phosphorylase, the last unknown enzyme in the Smirnoff-Wheeler pathway to ascorbic acid in plants.",
"A second GDP-L-gala... | [
2011,
2007,
2008,
2007,
2007
] | 5 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"hydrothermal vent metagenome"
] | [
47,
3395,
14
] | 3 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
5,
1,
1,
3,
4,
2,
12,
1,
11
] | 9 | true | Domain | GDPGP1-like, N-terminal domain | GDPGP1-like, N-terminal domain | GDPGP1_N | 9 |
IPR058867 | 58,867 | YtzJ | YtzJ | Family | 306 | false | false | This entry represents the YtzJ protein from B. subtilis and related bacterial proteins. This protein forms a small compact α/β domain composed of a three-stranded β sheet with two α-helices packed on one side. This protein family seems specific to bacilli. Structure prediction suggests this protein might form a homodim... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26326"
] | [
"YtzJ"
] | [
306
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacillales"
] | [
306
] | 1 | [] | [] | 0 | true | Family | YtzJ | YtzJ | YtzJ | 1 |
IPR058868 | 58,868 | ARM repeat, N-terminal, plant | ARM_7 | Domain | 1,401 | false | false | This entry represents the N-terminal in a set of uncharacterised plant proteins. This domain is composed of an α-solenoid structure composed of repeating pairs of α-helices. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26524"
] | [
"ARM_7"
] | [
1401
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1401
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
14,
5,
7
] | 3 | true | Domain | ARM repeat, N-terminal, plant | ARM repeat, N-terminal, plant | ARM_7 | 1 |
IPR058869 | 58,869 | YqzN/YkzM | YqzN_YkzM | Domain | 423 | false | false | This entry represents a small domain found in two B. subtilis proteins, YqzN and YkzM. This domain shows some structural similarity to members of the UBA domain superfamily. The function of these proteins is unknown. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26160"
] | [
"YqzN_YkzM"
] | [
423
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacillota",
"Caudoviricetes",
"Phytophthora kernoviae 00238/432"
] | [
408,
14,
1
] | 3 | [] | [] | 0 | true | Domain | YqzN/YkzM | YqzN/YkzM | YqzN_YkzM | 2 |
IPR058870 | 58,870 | YuzC | YuzC | Family | 636 | false | false | This entry represents an inner spore coat protein that contributes to spore protection and structural integrity. It is involved in the assembly and defence of the spore during bacterial sporulation. Experimental evidence, including protein fusion studies, supports a role for YuzC in the kinetics of spore coat formation... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26344"
] | [
"YuzC"
] | [
636
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00161548",
"PUB00161549"
] | [
"33052805",
"30168214"
] | [
"Diversity and evolutionary dynamics of spore-coat proteins in spore-forming species of Bacillales.",
"SpoVID functions as a non-competitive hub that connects the modules for assembly of the inner and outer spore coat layers in Bacillus subtilis."
] | [
2020,
2018
] | 2 | [] | [] | 0 | 0 | null | [
"Bacillati"
] | [
636
] | 1 | [] | [] | 0 | true | Family | YuzC | YuzC | YuzC | 7 |
IPR058871 | 58,871 | Zuotin, N-terminal domain | Zuotin_N | Domain | 1,550 | false | false | This entry represents the N-terminal domain of yeast Zuotin and similar proteins from fungi. Zuotin is a component of the ribosome-associated complex (RAC), which is a heterodimer of the Hsp70/DnaK-type chaperone SSZ1 and the Hsp40/DnaJ-type chaperone ZUO1. The RAC chaperone complex plays a role in regulating accurate ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26185"
] | [
"Zuotin_N"
] | [
1550
] | 1 | [
"REACTOME",
"REACTOME"
] | [
"R-SCE-3371453",
"R-SPO-3371453"
] | [
"REACTOME:R-SCE-3371453",
"REACTOME:R-SPO-3371453"
] | 2 | [
"5mb9",
"6sr6",
"7x3k",
"7z3n",
"7z3o"
] | 5 | [
"PUB00096579",
"PUB00158520"
] | [
"15908962",
"1396572"
] | [
"The Hsp70 Ssz1 modulates the function of the ribosome-associated J-protein Zuo1.",
"Zuotin, a putative Z-DNA binding protein in Saccharomyces cerevisiae."
] | [
2005,
1992
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1550
] | 1 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
1,
1,
1
] | 3 | true | Domain | Zuotin, N-terminal domain | Zuotin, N-terminal domain | Zuotin_N | 7 |
IPR058872 | 58,872 | Profilin fold domain, halobacteria | Halo_prof | Domain | 241 | false | false | This entry represents a profilin-fold domain that is found to be duplicated in a set of halobacterial proteins. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26420"
] | [
"Halo_prof"
] | [
241
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Halobacteriales"
] | [
241
] | 1 | [] | [] | 0 | true | Domain | Profilin fold domain, halobacteria | Profilin fold domain, halobacteria | Halo_prof | 9 |
IPR058873 | 58,873 | GAPS4, PD-(D/E)XK nuclease domain | PDDEXK_GAPS4 | Domain | 504 | false | false | This entry represents the PD-(D/E)XK domain found in the GAPS4 protein from Vibrio furnissii ( ) and similar prokaryotic proteins. The PD-(D/E)XK phosphodiesterase domain, is a widespread catalytic domain found in a diverse superfamily of nucleases. The domain is characterised by a conserved catalytic motif containing ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26115"
] | [
"PDDEXK_GAPS4"
] | [
504
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00161243"
] | [
"39443754"
] | [
"Gamma-Mobile-Trio systems are mobile elements rich in bacterial defensive and offensive tools."
] | [
2024
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Gegevirus ST437OXA245phi41",
"Stenosarchaea group",
"metagenomes"
] | [
486,
3,
3,
10,
2
] | 5 | [] | [] | 0 | true | Domain | GAPS4, PD-(D/E)XK nuclease domain | GAPS4, PD-(D/E)XK nuclease domain | PDDEXK_GAPS4 | 6 |
IPR058874 | 58,874 | Plant disease resistance, WDH | WHD_plant | Domain | 1,336 | false | false | This entry represents a Winged Helix Domain (WHD) found in plant disease resistance proteins. The domain is typically found C-terminal and adjacent to the NB-ARC domain in proteins often annotated as disease resistance proteins in plants. These proteins are involved in the plant immune response against pathogens. This ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25895"
] | [
"WHD_plant_disease"
] | [
1336
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Embryophyta"
] | [
1336
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
8,
10,
10
] | 3 | true | Domain | Plant disease resistance, WDH | Plant disease resistance, WDH | WHD_plant | 1 |
IPR058875 | 58,875 | Minor capsid decoration protein | DEC | Family | 104 | false | false | This entry represents the minor capsid decoration protein (DEC) of bacteriophage phiTE that infects the plant pathogen Pectobacterium atrosepticum. The DEC protein belongs to the β-tulip family and forms trimers at three-fold and quasi-three-fold axes of the capsid. Unlike other β-tulip proteins, the DEC features a C-t... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26074"
] | [
"Phage_DEC_PhiTE"
] | [
104
] | 1 | [] | [] | [] | 0 | [
"9cul",
"9mjn"
] | 2 | [
"PUB00161405"
] | [
"40188083"
] | [
"Global structural survey of the flagellotropic myophage φTE infecting agricultural pathogen Pectobacterium atrosepticum."
] | [
2025
] | 1 | [] | [] | 0 | 0 | null | [
"Pedobacter africanus",
"Viruses"
] | [
2,
102
] | 2 | [] | [] | 0 | true | Family | Minor capsid decoration protein | Minor capsid decoration protein | DEC | 6 |
IPR058877 | 58,877 | JAB/MPN domain-containing | JAB/MPN_dom-containing | Family | 408 | false | false | This entry represents a family of uncharacterised proteins from halobacteria that contain a JAB/MPN-like domain. Proteins in this group range from 130 to 160 amino acids in length. JAB/MPN domains are related to enzymes involved in deubiquitination. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26422"
] | [
"Halo_JAB_MPN"
] | [
408
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Halobacteria"
] | [
408
] | 1 | [] | [] | 0 | true | Family | JAB/MPN domain-containing | JAB/MPN domain-containing | JAB/MPN_dom-containing | 7 |
IPR058879 | 58,879 | NTF2-like domain, nematodes 2 | NTF2-like_dom_nem | Domain | 132 | false | false | This entry represents an NTF2-like domain found in a family of uncharacterised proteins from nematodes. The typical length of the proteins containing this domain ranges from approximately 450 to 550 amino acids. These proteins usually contain three copies of this domain. This domain belongs to the NTF2-like superfamily... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26529"
] | [
"NTF2_2_"
] | [
132
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Caenorhabditis"
] | [
132
] | 1 | [
"Caenorhabditis elegans"
] | [
5
] | 1 | true | Domain | NTF2-like domain, nematodes 2 | NTF2-like domain, nematodes 2 | NTF2-like_dom_nem | 2 |
IPR058880 | 58,880 | Alkaline phosphatase-like protein PglZ, N-terminal domain | PglZ_N | Domain | 521 | false | false | This entry represents the N-terminal domain of the PglZ protein (Alkaline phosphatase-like protein PglZ), part of the BREX (bacteriophage exclusion) systems that provide immunity against bacteriophages [ ]. This domain is found in type 2 BREX systems, previously called the phage growth limitation (Pgl) system, that con... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25862"
] | [
"PglZ_1st"
] | [
521
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00093365",
"PUB00105105",
"PUB00151239",
"PUB00161155"
] | [
"25452498",
"25592393",
"11972785",
"7642495"
] | [
"BREX is a novel phage resistance system widespread in microbial genomes.",
"The phage growth limitation system in Streptomyces coelicolor A(3)2 is a toxin/antitoxin system, comprising enzymes with DNA methyltransferase, protein kinase and ATPase activity.",
"Genetics of the phage growth limitation (Pgl) system... | [
2015,
2015,
2002,
1995
] | 4 | [] | [] | 0 | 0 | null | [
"Bacteria",
"ecological metagenomes"
] | [
515,
6
] | 2 | [] | [] | 0 | true | Domain | Alkaline phosphatase-like protein PglZ, N-terminal domain | Alkaline phosphatase-like protein PglZ, N-terminal domain | PglZ_N | 3 |
IPR058881 | 58,881 | Alkaline phosphatase-like protein PglZ, second domain | PglZ_2nd | Domain | 581 | false | false | This entry represents the second domain of Alkaline phosphatase-like protein PglZ from Streptomyces coelicolor and similar sequences from actinomycetes and some species from proteobacteria and planctomycetes. PglZ is part of the BREX (bacteriophage exclusion) systems that provide immunity against bacteriophages [ ]. Th... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25861"
] | [
"PglZ_2nd"
] | [
581
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00093365",
"PUB00105105",
"PUB00151239",
"PUB00161155"
] | [
"25452498",
"25592393",
"11972785",
"7642495"
] | [
"BREX is a novel phage resistance system widespread in microbial genomes.",
"The phage growth limitation system in Streptomyces coelicolor A(3)2 is a toxin/antitoxin system, comprising enzymes with DNA methyltransferase, protein kinase and ATPase activity.",
"Genetics of the phage growth limitation (Pgl) system... | [
2015,
2015,
2002,
1995
] | 4 | [] | [] | 0 | 0 | null | [
"Bacteria",
"unclassified sequences"
] | [
575,
6
] | 2 | [] | [] | 0 | true | Domain | Alkaline phosphatase-like protein PglZ, second domain | Alkaline phosphatase-like protein PglZ, second domain | PglZ_2nd | 8 |
IPR058882 | 58,882 | Alkaline phosphatase-like protein PglZ, C-terminal domain | PglZ_C | Domain | 669 | false | false | This entry represents the C-terminal α-helical domain of Alkaline phosphatase-like protein PglZ from Streptomyces coelicolor and similar sequences from actinomycetes and some species from proteobacteria and planctomycetes. PglZ is part of the BREX (bacteriophage exclusion) system that provides immunity against bacterio... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25863"
] | [
"PglZ_C"
] | [
669
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00093365",
"PUB00105105",
"PUB00151239",
"PUB00161155"
] | [
"25452498",
"25592393",
"11972785",
"7642495"
] | [
"BREX is a novel phage resistance system widespread in microbial genomes.",
"The phage growth limitation system in Streptomyces coelicolor A(3)2 is a toxin/antitoxin system, comprising enzymes with DNA methyltransferase, protein kinase and ATPase activity.",
"Genetics of the phage growth limitation (Pgl) system... | [
2015,
2015,
2002,
1995
] | 4 | [] | [] | 0 | 0 | null | [
"Bacteria",
"unclassified sequences"
] | [
661,
8
] | 2 | [] | [] | 0 | true | Domain | Alkaline phosphatase-like protein PglZ, C-terminal domain | Alkaline phosphatase-like protein PglZ, C-terminal domain | PglZ_C | 9 |
IPR058883 | 58,883 | Cilium assembly protein DZIP1 domain | DZIP1_dom | Domain | 2,300 | false | false | This domain is found in zebrafish Cilium assembly protein DZIP1 and similar sequences from animals. DZIP1 is a molecular adapter that recruits protein complexes required for cilium assembly and function to the cilium basal body. It is required for establishment of left-right asymmetry during embryogenesis [ ]. This dom... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25977"
] | [
"DZIP1"
] | [
2300
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-DME-5632684",
"R-DRE-5632684",
"R-HSA-5632684",
"R-MMU-5632684"
] | [
"REACTOME:R-DME-5632684",
"REACTOME:R-DRE-5632684",
"REACTOME:R-HSA-5632684",
"REACTOME:R-MMU-5632684"
] | 4 | [] | 0 | [
"PUB00076767",
"PUB00076768",
"PUB00097912",
"PUB00100315",
"PUB00100380",
"PUB00100381",
"PUB00100382",
"PUB00100383",
"PUB00161223",
"PUB00161224"
] | [
"15115751",
"19852954",
"31821146",
"33370260",
"27979967",
"32051257",
"23955340",
"31118289",
"15198976",
"28530676"
] | [
"The zebrafish iguana locus encodes Dzip1, a novel zinc-finger protein required for proper regulation of Hedgehog signaling.",
"The Zn finger protein Iguana impacts Hedgehog signaling by promoting ciliogenesis.",
"Dzip1 and Fam92 form a ciliary transition zone complex with cell type specific roles in Drosophila... | [
2004,
2010,
2019,
2020,
2017,
2020,
2013,
2019,
2004,
2017
] | 10 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
2300
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
13,
1,
3,
6,
8
] | 5 | true | Domain | Cilium assembly protein DZIP1 domain | Cilium assembly protein DZIP1 domain | DZIP1_dom | 5 |
IPR058884 | 58,884 | Cystin-1 | Cys1 | Family | 154 | false | false | This protein family from vertebrates includes mouse Cystin-1, a cilia-associated protein that has been associated to polycystic kidney disease [ , ]. Its structure is predicted to include two α helices. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26203"
] | [
"Cys1"
] | [
154
] | 1 | [
"REACTOME"
] | [
"R-HSA-5624138"
] | [
"REACTOME:R-HSA-5624138"
] | 1 | [] | 0 | [
"PUB00161199",
"PUB00161200"
] | [
"11854326",
"34521872"
] | [
"Cystin, a novel cilia-associated protein, is disrupted in the cpk mouse model of polycystic kidney disease.",
"Cystin genetic variants cause autosomal recessive polycystic kidney disease associated with altered Myc expression."
] | [
2002,
2021
] | 2 | [] | [] | 0 | 0 | null | [
"Amniota"
] | [
154
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
3,
3
] | 3 | true | Family | Cystin-1 | Cystin-1 | Cys1 | 5 |
IPR058885 | 58,885 | Winged helix domain, halobacteria | WHD_halobact | Domain | 208 | false | false | This entry represents a winged helix domain (WHD) found in a family of uncharacterised proteins in halobacteria. The domain is typically found in proteins ranging from approximately 580 to 660 amino acids in length. These domains are found C-terminal to a P-loop domain found in these proteins ( ). | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26491"
] | [
"WH_Halo"
] | [
208
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Halobacteriales"
] | [
208
] | 1 | [] | [] | 0 | true | Domain | Winged helix domain, halobacteria | Winged helix domain, halobacteria | WHD_halobact | 8 |
IPR058886 | 58,886 | eIF2D, SWIB domain | SWIB_eIF2D | Domain | 3,319 | false | false | This SWIB domain is found in the animal eukaryotic translation reinitiation factor 2D (elF2D), its yeast homologue Translation machinery-associated protein 64 (TMA64) and similar eukaryotic sequences. This domain is unique to elF2D and is not observed in other translation initiation factors. This domain along with the ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26291"
] | [
"SWIB_eIF2D"
] | [
3319
] | 1 | [] | [] | [] | 0 | [
"5oa3",
"5oa9",
"5w2f"
] | 3 | [
"PUB00147892"
] | [
"28732596"
] | [
"Structural and Functional Insights into Human Re-initiation Complexes."
] | [
2017
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Indivirus ILV1"
] | [
3318,
1
] | 2 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Zea mays"
] | [
6,
1,
2,
2,
4,
3,
9,
1,
13
] | 9 | true | Domain | eIF2D, SWIB domain | eIF2D, SWIB domain | SWIB_eIF2D | 8 |
IPR058887 | 58,887 | Membrane protein YuzI | YuzI-like | Family | 478 | false | false | This entry represents a family of integral membrane proteins related to uncharacterised Bacillus subtilis protein YuzI. These proteins are composed of two transmembrane helices. Members of this group are mainly found in Bacilli. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26135"
] | [
"YuzI"
] | [
478
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria"
] | [
478
] | 1 | [] | [] | 0 | true | Family | Membrane protein YuzI | Membrane protein YuzI | YuzI-like | 9 |
IPR058888 | 58,888 | GPI-anchored protein LLG1-like domain | LLG1-like | Domain | 1,716 | false | false | This domain is found in GPI-anchored protein LLG1 from Arabidopsis thaliana and similar plant proteins, including GPI-anchored protein LORELEI (LRE). These proteins are components of the FER-regulated Rho GTPase signalling complex, act as a chaperone and co-receptor for FER and are required for localisation of FER to t... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26578"
] | [
"LLG1"
] | [
1716
] | 1 | [] | [] | [] | 0 | [
"6a5d",
"6a5e"
] | 2 | [
"PUB00089419",
"PUB00089420",
"PUB00089421",
"PUB00161322",
"PUB00161323"
] | [
"19028964",
"26052747",
"27081182",
"31291642",
"20163554"
] | [
"Maternal control of male-gamete delivery in Arabidopsis involves a putative GPI-anchored protein encoded by the LORELEI gene.",
"Glycosylphosphatidylinositol-anchored proteins as chaperones and co-receptors for FERONIA receptor kinase signaling in Arabidopsis.",
"The Role of LORELEI in Pollen Tube Reception at... | [
2008,
2015,
2016,
2019,
2010
] | 5 | [] | [] | 0 | 0 | null | [
"Streptophytina"
] | [
1716
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
15,
19,
10
] | 3 | true | Domain | GPI-anchored protein LLG1-like domain | GPI-anchored protein LLG1-like domain | LLG1-like | 2 |
IPR058890 | 58,890 | YwtC-like | YwtC-like | Family | 156 | false | false | This entry represents a family of uncharacterised proteins from bacillales, including YwtC, a small protein found in Bacillus species that is associated with the machinery for poly-gamma-glutamic acid synthesis. However, its precise biochemical function remains unclear. Although its conservation across different strain... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26359"
] | [
"YwtC"
] | [
156
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00161550"
] | [
"38622505"
] | [
"Genomic characterization and related functional genes of γ- poly glutamic acid producing Bacillus subtilis."
] | [
2024
] | 1 | [] | [] | 0 | 0 | null | [
"Bacillota"
] | [
156
] | 1 | [] | [] | 0 | true | Family | YwtC-like | YwtC-like | YwtC-like | 2 |
IPR058891 | 58,891 | Cryptic plasmid protein A | CPPA | Family | 392 | false | false | This entry represents the Cryptic plasmid protein A (CppA) found in small gonococcal plasmids such as pJD1 from Neisseria gonorrhoeae. The function of this protein and the plasmid it resides on is currently unknown. This short protein contains a small helical domain composed of three α-helices. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25860"
] | [
"CPPA"
] | [
392
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"mine drainage metagenome"
] | [
389,
3
] | 2 | [] | [] | 0 | true | Family | Cryptic plasmid protein A | Cryptic plasmid protein A | CPPA | 9 |
IPR058892 | 58,892 | ATP phosphoribosyltransferase-like | HisG-like | Family | 309 | false | false | This entry represents a family of halobacterial proteins that are homologous to the ATP phosphoribosyltransferase enzyme HisG. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25936"
] | [
"HisG_halo"
] | [
309
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Halobacteriales"
] | [
309
] | 1 | [] | [] | 0 | true | Family | ATP phosphoribosyltransferase-like | ATP phosphoribosyltransferase-like | HisG-like | 2 |
IPR058893 | 58,893 | Ribbon-helix-helix protein | RHH-containing | Family | 268 | false | false | This entry represents a family of halobacterial Ribbon-helix-helix proteins. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26048"
] | [
"RHH_11"
] | [
268
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Halobacteria"
] | [
268
] | 1 | [] | [] | 0 | true | Family | Ribbon-helix-helix protein | Ribbon-helix-helix protein | RHH-containing | 2 |
IPR058894 | 58,894 | Phage phiTE_211, coil containing protein-like | PhiTE_211_coil-containing-like | Family | 219 | false | false | This entry represents a family of uncharacterised phage proteins that includes Phage phiTE_211 coil containing protein ( ). | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26210"
] | [
"Phage_phiTE_211"
] | [
219
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Gammaproteobacteria",
"Viruses"
] | [
25,
194
] | 2 | [] | [] | 0 | true | Family | Phage phiTE_211, coil containing protein-like | Phage phiTE_211, coil containing protein-like | PhiTE_211_coil-containing-like | 1 |
IPR058895 | 58,895 | YkoA-like | YkoA-like | Family | 76 | false | false | This family represents a set of uncharacterised integral membrane proteins related to B. subtilis YkoA ( ). These proteins contain three predicted transmembrane helices. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26313"
] | [
"YkoA"
] | [
76
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacillaceae"
] | [
76
] | 1 | [] | [] | 0 | true | Family | YkoA-like | YkoA-like | YkoA-like | 3 |
IPR058899 | 58,899 | TGFBR3/Endoglin-like, N-terminal domain | TGFBR3/Endoglin-like_N | Domain | 2,345 | false | false | This domain is found at the N-terminal end of human Transforming growth factor beta receptor type 3 (TGFBR3), Endoglin (ENG) and similar proteins mainly found in animals. TGFBR3 is a cell surface receptor that regulates diverse cellular processes including cell proliferation, differentiation, migration, and apoptosis. ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26060"
] | [
"TGFBR3_N"
] | [
2345
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-HSA-1502540",
"R-HSA-190370",
"R-HSA-190373",
"R-HSA-201451",
"R-HSA-2173789",
"R-HSA-9839383",
"R-HSA-9839389",
"R-HSA-9839394",
"R-HSA-9839397",
"R-HSA-9839406",
"R-MMU-1502540",
"R-MMU-190370",
"R-MMU-190373",
"R-MMU-201451",
"R-MMU-2173789",
"R-MMU-9839383",
"R-MMU-9839389",
... | [
"REACTOME:R-HSA-1502540",
"REACTOME:R-HSA-190370",
"REACTOME:R-HSA-190373",
"REACTOME:R-HSA-201451",
"REACTOME:R-HSA-2173789",
"REACTOME:R-HSA-9839383",
"REACTOME:R-HSA-9839389",
"REACTOME:R-HSA-9839394",
"REACTOME:R-HSA-9839397",
"REACTOME:R-HSA-9839406",
"REACTOME:R-MMU-1502540",
"REACTOME:R... | 28 | [
"5hzw",
"5i04",
"6mzn",
"6mzp",
"7lbg",
"9b9f",
"9fdy",
"9fk5",
"9fkp"
] | 9 | [
"PUB00107060",
"PUB00107063",
"PUB00107064",
"PUB00107068",
"PUB00154324",
"PUB00161476",
"PUB00161477",
"PUB00161478",
"PUB00161479",
"PUB00161480",
"PUB00161481",
"PUB00161482",
"PUB00161483",
"PUB00161668"
] | [
"21737454",
"22347366",
"23300529",
"28564608",
"33626330",
"12958365",
"19416857",
"17540773",
"10625534",
"28530658",
"17704211",
"21871877",
"31327662",
"7894484"
] | [
"Soluble endoglin specifically binds bone morphogenetic proteins 9 and 10 via its orphan domain, inhibits blood vessel formation, and suppresses tumor growth.",
"Structural and functional insights into endoglin ligand recognition and binding.",
"Endoglin requirement for BMP9 signaling in endothelial cells revea... | [
2011,
2012,
2012,
2017,
2021,
2003,
2009,
2007,
2000,
2017,
2007,
2011,
2019,
1994
] | 14 | [] | [] | 0 | 0 | null | [
"Eumetazoa"
] | [
2345
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
25,
19,
7,
11
] | 4 | true | Domain | TGFBR3/Endoglin-like, N-terminal domain | TGFBR3/Endoglin-like, N-terminal domain | TGFBR3/Endoglin-like_N | 8 |
IPR058900 | 58,900 | TTC28, C-terminal domain | TTC28_C | Domain | 1,973 | false | false | This domain is found towards the C-terminal end of human Tetratricopeptide repeat protein 28 (TTC28) and similar sequences mainly found in animals. TTC28 may be involved in the condensation of spindle midzone microtubules during mitosis, leading to the formation of midbody [ ]. This domain is predicted to show an α-β c... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26117"
] | [
"TTC28_C"
] | [
1973
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00069413"
] | [
"23036704"
] | [
"A novel big protein TPRBK possessing 25 units of TPR motif is essential for the progress of mitosis and cytokinesis."
] | [
2012
] | 1 | [] | [] | 0 | 0 | null | [
"Metazoa"
] | [
1973
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
4,
2,
3,
2,
9
] | 5 | true | Domain | TTC28, C-terminal domain | TTC28, C-terminal domain | TTC28_C | 8 |
IPR058901 | 58,901 | ATRX, C-terminal domain | ATRX_C | Domain | 1,495 | false | false | This entry represents the C-terminal domain in Transcriptional regulator ATRX and similar proteins from vertebrates. The function of the C-terminal has not yet been elucidated. It contains an all-α-helical structure. ATRX is a chromatin-associated protein involved in transcriptional regulation, chromatin remodelling, D... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26143"
] | [
"ATRX_C"
] | [
1495
] | 1 | [
"EC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"3.6.4.12",
"R-HSA-9670095",
"R-HSA-9670613",
"R-HSA-9670615",
"R-MMU-9670095"
] | [
"EC:3.6.4.12",
"REACTOME:R-HSA-9670095",
"REACTOME:R-HSA-9670613",
"REACTOME:R-HSA-9670615",
"REACTOME:R-MMU-9670095"
] | 5 | [] | 0 | [
"PUB00129121",
"PUB00161133"
] | [
"21653732",
"34162889"
] | [
"Role of ATRX in chromatin structure and function: implications for chromosome instability and human disease.",
"ATRX promotes heterochromatin formation to protect cells from G-quadruplex DNA-mediated stress."
] | [
2011,
2021
] | 2 | [] | [] | 0 | 0 | null | [
"Vertebrata"
] | [
1495
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
4,
6,
1,
4
] | 4 | true | Domain | ATRX, C-terminal domain | ATRX, C-terminal domain | ATRX_C | 9 |
IPR058903 | 58,903 | YLPM1-like, spectrin repeat | Spectrin_YLPM1-like | Domain | 1,662 | false | false | This entry represents a spectrin repeat found in human YLP motif-containing protein 1 (YLPM1) and similar animal sequences. YLPM1 plays a role in the reduction of telomerase activity during differentiation of embryonic stem cells by binding to the core promoter of TERT and controlling its down-regulation [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26583"
] | [
"Spectrin_YLPM1"
] | [
1662
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00060398"
] | [
"15511642"
] | [
"A role for nucleoprotein Zap3 in the reduction of telomerase activity during embryonic stem cell differentiation."
] | [
2004
] | 1 | [] | [] | 0 | 0 | null | [
"Bilateria"
] | [
1662
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
8,
5,
6,
6
] | 5 | true | Domain | YLPM1-like, spectrin repeat | YLPM1-like, spectrin repeat | Spectrin_YLPM1-like | 2 |
IPR058904 | 58,904 | PARP4, MVP-ID C-terminal domain | PARP4_MVP-ID | Domain | 1,049 | false | false | This entry represents the major vault protein interaction domain (MVP-ID) at the C-terminal in PARP4 proteins. The MVP-ID domain facilitates PARP4 interaction with the Major Vault Protein (MVP) and localisation inside the vault ribonucleoprotein complex. It is predicted to contain a helical structure [ ]. Members of th... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26156"
] | [
"PARP4_MVP-ID"
] | [
1049
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-196807",
"R-HSA-9683610",
"R-HSA-9694631"
] | [
"REACTOME:R-HSA-196807",
"REACTOME:R-HSA-9683610",
"REACTOME:R-HSA-9694631"
] | 3 | [
"9bw6",
"9bw7"
] | 2 | [
"PUB00075207",
"PUB00146699",
"PUB00161392",
"PUB00161393"
] | [
"21840394",
"25043379",
"37971310",
"38979142"
] | [
"The poly(ADP-ribose) polymerases (PARPs): new roles in intracellular transport.",
"Family-wide analysis of poly(ADP-ribose) polymerase activity.",
"Structural and biochemical analysis of the PARP1-homology region of PARP4/vault PARP.",
"Structural Insights into the Roles of PARP4 and NAD <sup>+</sup> in the ... | [
2012,
2014,
2023,
2024
] | 4 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1049
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
1,
1,
3
] | 4 | true | Domain | PARP4, MVP-ID C-terminal domain | PARP4, MVP-ID C-terminal domain | PARP4_MVP-ID | 5 |
IPR058905 | 58,905 | PARP4, WGR-like domain | WGR-like_PARP4 | Domain | 871 | false | false | This entry represents the WGR-like domain in PARP4 proteins. The WGR domain is named after its most conserved central motif (Trp-Gly-Arg residues). In PARP4, it forms part of the BRCT-WGR-CAT region, which regulates catalytic activity [ ]. In this entry, the conservation of Gly and Arg is evident, but the conservation ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26166"
] | [
"WGR-like_PARP4"
] | [
871
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-196807",
"R-HSA-9683610",
"R-HSA-9694631"
] | [
"REACTOME:R-HSA-196807",
"REACTOME:R-HSA-9683610",
"REACTOME:R-HSA-9694631"
] | 3 | [
"9bw6",
"9bw7"
] | 2 | [
"PUB00075207",
"PUB00075208",
"PUB00146699",
"PUB00161392"
] | [
"21840394",
"10455009",
"25043379",
"37971310"
] | [
"The poly(ADP-ribose) polymerases (PARPs): new roles in intracellular transport.",
"Poly(ADP-ribosyl)ation reactions in the regulation of nuclear functions.",
"Family-wide analysis of poly(ADP-ribose) polymerase activity.",
"Structural and biochemical analysis of the PARP1-homology region of PARP4/vault PARP.... | [
2012,
1999,
2014,
2023
] | 4 | [] | [] | 0 | 0 | null | [
"Gnathostomata"
] | [
871
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
3,
1,
2
] | 4 | true | Domain | PARP4, WGR-like domain | PARP4, WGR-like domain | WGR-like_PARP4 | 5 |
IPR058906 | 58,906 | Apoptosis-resistant E3 ubiquitin protein ligase 1, N-terminal domain | AREL1_N | Domain | 1,146 | false | false | This entry describes the N-terminal domain in AREL1 and similar sequences found in animals. This domain is 55 amino acids long and adopts an all α-helical fold. It is often found adjacent to . Apoptosis-resistant E3 ubiquitin protein ligase 1 (AREL1) proteins function as E3 ubiquitin-protein ligases, catalysing the for... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25915"
] | [
"AREL1_N"
] | [
1146
] | 1 | [
"REACTOME",
"REACTOME"
] | [
"R-HSA-983168",
"R-MMU-983168"
] | [
"REACTOME:R-HSA-983168",
"REACTOME:R-MMU-983168"
] | 2 | [] | 0 | [
"PUB00161123",
"PUB00161124",
"PUB00161125"
] | [
"31578312",
"23479728",
"25752577"
] | [
"KIAA0317 regulates pulmonary inflammation through SOCS2 degradation.",
"Identification of a novel anti-apoptotic E3 ubiquitin ligase that ubiquitinates antagonists of inhibitor of apoptosis proteins SMAC, HtrA2, and ARTS.",
"Assembly and specific recognition of k29- and k33-linked polyubiquitin."
] | [
2019,
2013,
2015
] | 3 | [] | [] | 0 | 0 | null | [
"Gnathostomata"
] | [
1146
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
6,
9,
2
] | 4 | true | Domain | Apoptosis-resistant E3 ubiquitin protein ligase 1, N-terminal domain | Apoptosis-resistant E3 ubiquitin protein ligase 1, N-terminal domain | AREL1_N | 7 |
IPR058907 | 58,907 | Broad-specificity ulvan lyase, N-terminal domain | P29_N | Domain | 309 | false | false | This entry represents the N-terminal domain of Broad-specificity ulvan lyase from Formosa agariphila P29) and similar prokaryotic sequences. P29 is involved in the degradation of ulvan, a major cell wall polysaccharide from green seaweeds of the genus Ulva [ ]. The N-terminal domain is rich in α-helices and adopts an (... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25840"
] | [
"Ulvan_lyase_N"
] | [
309
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00093668",
"PUB00161512"
] | [
"31285597",
"30279430"
] | [
"A marine bacterial enzymatic cascade degrades the algal polysaccharide ulvan.",
"A novel ulvan lyase family with broad-spectrum activity from the ulvan utilisation loci of Formosa agariphila KMM 3901."
] | [
2019,
2018
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Stenosarchaea group",
"ecological metagenomes"
] | [
301,
3,
5
] | 3 | [] | [] | 0 | true | Domain | Broad-specificity ulvan lyase, N-terminal domain | Broad-specificity ulvan lyase, N-terminal domain | P29_N | 3 |
IPR058909 | 58,909 | cGAS/DncV-like nucleotidyltransferase, C-terminal helical domain | CD_NTase_C | Domain | 654 | false | false | This entry represents the C-terminal helical domain of a group of prokaryotic cGAS/DncV-like nucleotidyltransferases (CD-NTases). CD-NTases are a family of enzymes that synthesise cyclic dinucleotides (CDNs) and cyclic trinucleotides (CTNs) which function as signalling molecules [ ]. While the N-terminal domain contain... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26305"
] | [
"CD_NTase_C"
] | [
654
] | 1 | [
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC"
] | [
"2.7.7.-",
"PWY-6322",
"PWY-6626",
"PWY-6749",
"PWY-6955",
"PWY-6998",
"PWY-7127",
"PWY-7419",
"PWY-7529",
"PWY-7706",
"PWY-7719",
"PWY-7735",
"PWY-7737",
"PWY-7769",
"PWY-7888",
"PWY-7904",
"PWY-8117",
"PWY-8179"
] | [
"EC:2.7.7.-",
"METACYC:PWY-6322",
"METACYC:PWY-6626",
"METACYC:PWY-6749",
"METACYC:PWY-6955",
"METACYC:PWY-6998",
"METACYC:PWY-7127",
"METACYC:PWY-7419",
"METACYC:PWY-7529",
"METACYC:PWY-7706",
"METACYC:PWY-7719",
"METACYC:PWY-7735",
"METACYC:PWY-7737",
"METACYC:PWY-7769",
"METACYC:PWY-7... | 18 | [
"6e0k",
"6e0l",
"6e0m",
"6e0n",
"6e0o",
"6wt8",
"6wt9",
"7x4a",
"7x4c",
"7x4f",
"7x4g",
"7x4p",
"7x4q",
"7x4t",
"8hyk"
] | 15 | [
"PUB00106182",
"PUB00161173"
] | [
"30787435",
"37604815"
] | [
"Bacterial cGAS-like enzymes synthesize diverse nucleotide signals.",
"Crystal structure and functional implications of cyclic di-pyrimidine-synthesizing cGAS/DncV-like nucleotidyltransferases."
] | [
2019,
2023
] | 2 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Syncephalis pseudoplumigaleata",
"metagenomes",
"uncultured Caudovirales phage"
] | [
39,
602,
1,
11,
1
] | 5 | [] | [] | 0 | true | Domain | cGAS/DncV-like nucleotidyltransferase, C-terminal helical domain | cGAS/DncV-like nucleotidyltransferase, C-terminal helical domain | CD_NTase_C | 9 |
IPR058910 | 58,910 | Protein of unknown function DUF8186, central domain | DUF8186_M | Domain | 317 | false | false | This entry represents the central domain found in a family of uncharacterised proteins predominantly found in Halobacteria. The proteins in this family are typically around 550-580 amino acids in length. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26590"
] | [
"DUF8186_M"
] | [
317
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Halobacteria"
] | [
317
] | 1 | [] | [] | 0 | true | Domain | Protein of unknown function DUF8186, central domain | Protein of unknown function DUF8186, central domain | DUF8186_M | 8 |
IPR058911 | 58,911 | Protein of unknown function DUF8186, C-terminal domain | DUF8186_C | Domain | 296 | false | false | This entry represents the C-terminal domain found in a family of uncharacterised proteins from Halobacteria. The proteins in this family are typically around 550-580 amino acids in length. This domain is predicted to adopt an Ig-like fold. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26591"
] | [
"DUF8186_C"
] | [
296
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Halobacteria"
] | [
296
] | 1 | [] | [] | 0 | true | Domain | Protein of unknown function DUF8186, C-terminal domain | Protein of unknown function DUF8186, C-terminal domain | DUF8186_C | 4 |
IPR058912 | 58,912 | Helix-turn-helix domain, animal | HTH_animal | Domain | 11,299 | false | false | This predicted helix-turn-helix (HTH) domain is found in a group of uncharacterised proteins mainly found in animals. Many members of this family are annotated as reverse transcriptases, some of them also harbouring . | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26215"
] | [
"HTH_animal"
] | [
11299
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bracoviriform congregatae",
"Eukaryota",
"Pseudomonadota",
"invertebrate metagenome"
] | [
1,
11295,
2,
1
] | 4 | [
"Drosophila melanogaster"
] | [
2
] | 1 | true | Domain | Helix-turn-helix domain, animal | Helix-turn-helix domain, animal | HTH_animal | 8 |
IPR058913 | 58,913 | Integrase core domain, putative | Integrase_dom_put | Domain | 8,749 | false | false | This domain is homologous to the integrase central catalytic domain. Members of this group are mainly found in animals and fungi. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24764"
] | [
"rva_4"
] | [
8749
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
157,
8583,
9
] | 3 | [
"Danio rerio"
] | [
22
] | 1 | true | Domain | Integrase core domain, putative | Integrase core domain, putative | Integrase_dom_put | 8 |
IPR058916 | 58,916 | PH domain 40 | PH_40 | Domain | 367 | false | false | This entry represents a bacterial PH domain found in uncharacterised proteins. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26566"
] | [
"PH_40"
] | [
367
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Leptocylindrus danicus",
"ecological metagenomes"
] | [
361,
1,
5
] | 3 | [] | [] | 0 | true | Domain | PH domain 40 | PH domain 40 | PH_40 | 7 |
IPR058917 | 58,917 | RNA-editing substrate-binding complex 6 protein domain | RESC6_dom | Domain | 3,052 | false | false | This domain is found in the RNA-editing substrate-binding complex 6 protein (RESC6, ) from Trypanosoma brucei, a component of RESC which together with RECC forms the editosome that orchestrates guide RNA (gRNA)-programmed editing to recode cryptic mitochondrial transcripts into messenger RNAs [ ]. RESC stabilises gRNAs... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26188"
] | [
"RESC6"
] | [
3052
] | 1 | [] | [] | [] | 0 | [
"8fn4",
"8fn6",
"8fnc",
"8fnf",
"8fni",
"8fnk",
"9g6k",
"9i05"
] | 8 | [
"PUB00160174"
] | [
"37410820"
] | [
"Structural basis of gRNA stabilization and mRNA recognition in trypanosomal RNA editing."
] | [
2023
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota"
] | [
39,
3013
] | 2 | [] | [] | 0 | true | Domain | RNA-editing substrate-binding complex 6 protein domain | RNA-editing substrate-binding complex 6 protein domain | RESC6_dom | 2 |
IPR058918 | 58,918 | Kalirin/TRIO-like, spectrin repeats | KALRN/TRIO-like_spectrin | Domain | 5,240 | false | false | This entry represents a region of spectrin repeats found in human Kalirin (KALRN) and similar proteins from animals. KALRN activates specific Rho GTPase family members, thereby inducing various signalling mechanisms that regulate neuronal shape, growth, and plasticity, through their effects on the actin cytoskeleton [ ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23323"
] | [
"Spectrin_6"
] | [
5240
] | 1 | [
"EC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
... | [
"2.7.11.1",
"R-DRE-193648",
"R-DRE-416476",
"R-DRE-416482",
"R-DRE-418885",
"R-DRE-8980692",
"R-DRE-9013148",
"R-DRE-9013149",
"R-DRE-9013404",
"R-DRE-9013408",
"R-DRE-9013423",
"R-HSA-193648",
"R-HSA-3928662",
"R-HSA-416476",
"R-HSA-416482",
"R-HSA-418885",
"R-HSA-5687128",
"R-HSA... | [
"EC:2.7.11.1",
"REACTOME:R-DRE-193648",
"REACTOME:R-DRE-416476",
"REACTOME:R-DRE-416482",
"REACTOME:R-DRE-418885",
"REACTOME:R-DRE-8980692",
"REACTOME:R-DRE-9013148",
"REACTOME:R-DRE-9013149",
"REACTOME:R-DRE-9013404",
"REACTOME:R-DRE-9013408",
"REACTOME:R-DRE-9013423",
"REACTOME:R-HSA-193648"... | 49 | [] | 0 | [
"PUB00006347",
"PUB00068737",
"PUB00156133",
"PUB00161669",
"PUB00161673",
"PUB00161674"
] | [
"8643598",
"10023074",
"22155786",
"10341202",
"27418539",
"32109419"
] | [
"The multidomain protein Trio binds the LAR transmembrane tyrosine phosphatase, contains a protein kinase domain, and has separate rac-specific and rho-specific guanine nucleotide exchange factor domains.",
"Duet is a novel serine/threonine kinase with Dbl-Homology (DH) and Pleckstrin-Homology (PH) domains.",
"... | [
1996,
1999,
2011,
1999,
2016,
2020
] | 6 | [] | [] | 0 | 0 | null | [
"Eumetazoa"
] | [
5240
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
45,
4,
23,
7,
15
] | 5 | true | Domain | Kalirin/TRIO-like, spectrin repeats | Kalirin/TRIO-like, spectrin repeats | KALRN/TRIO-like_spectrin | 8 |
IPR058919 | 58,919 | Pep3/Vps18, RING C-terminal domain | Pep3/Vps18_RING_C | Domain | 4,137 | false | false | This entry represents the RING C-terminal domain in Vps18, Vacuolar membrane protein pep3 (Pep3) [ , ] and similar animal proteins. This domain is a specialised type of Zn-finger of 40 to 60 residues that binds two atoms of zinc, and is probably involved in mediating protein-protein interactions [ ]. Vacuolar sorting p... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26148"
] | [
"VPS18_RING_C"
] | [
4137
] | 1 | [
"REACTOME"
] | [
"R-HSA-9754560"
] | [
"REACTOME:R-HSA-9754560"
] | 1 | [
"7zu0",
"8dit",
"8qx8"
] | 3 | [
"PUB00005712",
"PUB00020011",
"PUB00053551",
"PUB00053803",
"PUB00062954",
"PUB00063476",
"PUB00073490",
"PUB00073491",
"PUB00090016",
"PUB00097428",
"PUB00161515",
"PUB00161516",
"PUB00161517",
"PUB00161518",
"PUB00161519",
"PUB00161675",
"PUB00161676"
] | [
"8317827",
"9065698",
"16000385",
"12006978",
"16601699",
"10549280",
"11382755",
"10978279",
"26783301",
"25783203",
"24501423",
"25273556",
"29463724",
"18923146",
"22160599",
"23351085",
"24554770"
] | [
"The RING finger. A novel protein sequence motif related to the zinc finger.",
"Molecular characterization of the deep orange (dor) gene of Drosophila melanogaster.",
"A genetic screen in zebrafish identifies the mutants vps18, nf2 and foie gras as models of liver disease.",
"Insertional mutagenesis in zebraf... | [
1993,
1997,
2005,
2002,
2006,
1999,
2001,
2000,
2016,
2015,
2014,
2014,
2018,
2009,
2012,
2013,
2014
] | 17 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"viral metagenome"
] | [
4136,
1
] | 2 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
4,
1,
2,
2,
1,
4,
1,
2,
2,
1,
1,
7
] | 12 | true | Domain | Pep3/Vps18, RING C-terminal domain | Pep3/Vps18, RING C-terminal domain | Pep3/Vps18_RING_C | 3 |
IPR058920 | 58,920 | PAP/OAS1 substrate-binding-related domain | PAP-OAS1-bd-rel | Domain | 3,660 | false | false | This entry represents a domain in uncharacterised proteins from plants that shows similarity to the the PAP/OAS1 substrate-binding main. This domain is usually found adjacent to . The PAP/OAS1 proteins bind ATP and interact with RNA. The OAS1 substrate-binding domain enables catalytic 2-5A synthesis (ATP coordination) ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26180"
] | [
"PAP-OAS1"
] | [
3660
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00161383",
"PUB00161384"
] | [
"38603810",
"38423012"
] | [
"Distinct domain organization and diversity of 2'-5'-oligoadenylate synthetases.",
"Oligoadenylate synthetase 1 displays dual antiviral mechanisms in driving translational shutdown and protecting interferon production."
] | [
2024,
2024
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
3660
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
31,
18,
51
] | 3 | true | Domain | PAP/OAS1 substrate-binding-related domain | PAP/OAS1 substrate-binding-related domain | PAP-OAS1-bd-rel | 8 |
IPR058921 | 58,921 | PAP/OAS1-related | PAP/OAS1-rel | Family | 4,056 | false | false | This family includes a group of uncharacterised proteins mainly found in plants. Members often contain and are thought to be related to PAP/OAS1 proteins. The PAP/OAS1 proteins bind ATP and interact with RNA. The OAS1 substrate-binding domain enables catalytic 2-5A synthesis (ATP coordination) and non-catalytic RNA sta... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR45979"
] | [
""
] | [
4056
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00161383",
"PUB00161384"
] | [
"38603810",
"38423012"
] | [
"Distinct domain organization and diversity of 2'-5'-oligoadenylate synthetases.",
"Oligoadenylate synthetase 1 displays dual antiviral mechanisms in driving translational shutdown and protecting interferon production."
] | [
2024,
2024
] | 2 | [] | [] | 0 | 0 | null | [
"Bacillati",
"Eukaryota"
] | [
19,
4037
] | 2 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
32,
19,
60
] | 3 | true | Family | PAP/OAS1-related | PAP/OAS1-related | PAP/OAS1-rel | 2 |
IPR058922 | 58,922 | Disease resistance protein, winged helix domain | WHD_DRP | Domain | 78,303 | false | false | This entry represents a winged helix-turn-helix domain (WHD) found in plant resistance proteins, including RGA4 from Oryza sativa [ ], RPP13-like protein 4 from Arabidopsis thaliana [ , , ] and NRC2a from Nicotiana benthamiana [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23559"
] | [
"WHD_DRP"
] | [
78303
] | 1 | [] | [] | [] | 0 | [
"6j5t",
"6j5u",
"6j5v",
"6j5w",
"6j6i",
"6s2p",
"7xc2",
"7xe0",
"7xvg",
"7xx2",
"8bv0",
"8rfh",
"8xuo",
"8xuq",
"8xuv",
"9cc8",
"9cc9",
"9fp6",
"9fyc",
"9h2l",
"9h4i",
"9h73",
"9ri9",
"9ria"
] | 24 | [
"PUB00155971",
"PUB00155972",
"PUB00155973",
"PUB00161677",
"PUB00161678"
] | [
"28652264",
"30948526",
"30948527",
"21251109",
"39504373"
] | [
"Analysis of the ZAR1 Immune Complex Reveals Determinants for Immunity and Molecular Interactions.",
"Ligand-triggered allosteric ADP release primes a plant NLR complex.",
"Reconstitution and structure of a plant NLR resistosome conferring immunity.",
"A multifaceted genomics approach allows the isolation of ... | [
2017,
2019,
2019,
2011,
2024
] | 5 | [] | [] | 0 | 0 | null | [
"Embryophyta"
] | [
78303
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
361,
1303,
490
] | 3 | true | Domain | Disease resistance protein, winged helix domain | Disease resistance protein, winged helix domain | WHD_DRP | 5 |
IPR058923 | 58,923 | RCC1-like domain | RCC1-like_dom | Domain | 45,206 | false | false | This entry represents the RCC1-like domain (RLD) of a number of proteins including human RCC1 (Regulator of chromosome condensation) [ , , ]. These proteins are typically composed of 7 blades that form a propeller structure. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25390"
] | [
"WD40_RLD"
] | [
45206
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-CEL-1169408",
"R-CEL-936440",
"R-CEL-9615933",
"R-CEL-983168",
"R-CEL-9833482",
"R-CEL-9909505",
"R-DME-5693565",
"R-DME-9615933",
"R-DME-983168",
"R-HSA-1169408",
"R-HSA-141444",
"R-HSA-165054",
"R-HSA-168928",
"R-HSA-180746",
"R-HSA-2467813",
"R-HSA-2500257",
"R-HSA-2980767",
... | [
"REACTOME:R-CEL-1169408",
"REACTOME:R-CEL-936440",
"REACTOME:R-CEL-9615933",
"REACTOME:R-CEL-983168",
"REACTOME:R-CEL-9833482",
"REACTOME:R-CEL-9909505",
"REACTOME:R-DME-5693565",
"REACTOME:R-DME-9615933",
"REACTOME:R-DME-983168",
"REACTOME:R-HSA-1169408",
"REACTOME:R-HSA-141444",
"REACTOME:R-... | 51 | [
"1a12",
"1i2m",
"3kci",
"3mvd",
"3of7",
"4d9s",
"4dnu",
"4dnv",
"4dnw",
"4jhn",
"4jhp",
"4naa",
"4nbm",
"4nc4",
"4o2w",
"4qam",
"5gwn",
"5hq2",
"5t94",
"5tbk",
"5xgs",
"6dd7",
"6xzl",
"6xzm",
"6xzn",
"7q40",
"7q41",
"7q42",
"7q43",
"7q44",
"7q45",
"7q46"... | 37 | [
"PUB00073461",
"PUB00160707",
"PUB00161679"
] | [
"20668449",
"29042532",
"22215983"
] | [
"NRMT is an alpha-N-methyltransferase that methylates RCC1 and retinoblastoma protein.",
"Three-dimensional context rather than NLS amino acid sequence determines importin α subtype specificity for RCC1.",
"Mitotic spindle assembly around RCC1-coated beads in Xenopus egg extracts."
] | [
2010,
2017,
2011
] | 3 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"metagenomes"
] | [
31,
3545,
41470,
84,
76
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
118,
5,
59,
10,
56,
35,
3,
60,
53,
1,
2,
154
] | 12 | true | Domain | RCC1-like domain | RCC1-like domain | RCC1-like_dom | 4 |
IPR058924 | 58,924 | N-acetyl-gamma-glutamyl-phosphate reductase, dimerisation domain | AGPR_dimerisation_dom | Domain | 27,596 | false | false | This entry represents the dimerisation domain found in N-acetyl-gamma-glutamyl-phosphate reductase (AGPR) and related sequences not included in [ , , ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF22698"
] | [
"Semialdhyde_dhC_1"
] | [
27596
] | 1 | [
"EC",
"EC",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"1.2.1",
"1.2.1.38",
"PWY-5154",
"R-DDI-70635",
"R-SCE-70635",
"R-SPO-70635"
] | [
"EC:1.2.1",
"EC:1.2.1.38",
"METACYC:PWY-5154",
"REACTOME:R-DDI-70635",
"REACTOME:R-SCE-70635",
"REACTOME:R-SPO-70635"
] | 6 | [
"1vkn",
"1xyg",
"2cvo",
"2g17",
"2i3a",
"2i3g",
"2nqt",
"2ozp",
"2q49",
"3dr3",
"5ein",
"5eio",
"7nni",
"7nnq",
"7nnr",
"7not",
"7nph",
"7npj",
"8afu",
"8afv"
] | 20 | [
"PUB00040104",
"PUB00041590",
"PUB00083920"
] | [
"16240442",
"17316682",
"26966182"
] | [
"Crystal structure of putative N-acetyl-gamma-glutamyl-phosphate reductase (AK071544) from rice (Oryza sativa).",
"Crystal structure of N-acetyl-gamma-glutamyl-phosphate reductase from Mycobacterium tuberculosis in complex with NADP(+).",
"Crystal Structure of the LysY·LysW Complex from Thermus thermophilus."
] | [
2005,
2007,
2016
] | 3 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Siphoviridae sp. ctBLh2",
"unclassified sequences"
] | [
820,
23444,
2757,
1,
574
] | 5 | [
"Arabidopsis thaliana",
"Escherichia coli (strain K12)",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)",
"Zea mays"
] | [
6,
1,
1,
7,
1,
1,
3
] | 7 | true | Domain | N-acetyl-gamma-glutamyl-phosphate reductase, dimerisation domain | N-acetyl-gamma-glutamyl-phosphate reductase, dimerisation domain | AGPR_dimerisation_dom | 8 |
IPR058925 | 58,925 | Oxidoreductase AcuF-like, C2H2 type zinc-finger | Znf-C2H2_AcuF | Domain | 3,038 | false | false | This C2H2 type zinc-finger is found in Oxidoreductase acuF from Aspergillus aculeatus and similar proteins from ascomycetes. AcuF is part of the gene cluster that mediates the biosynthesis of aculins [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26082"
] | [
"zf-C2H2_AcuF"
] | [
3038
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00161551"
] | [
"26374386"
] | [
"Investigation of a 6-MSA Synthase Gene Cluster in Aspergillus aculeatus Reveals 6-MSA-derived Aculinic Acid, Aculins A-B and Epi-Aculin A."
] | [
2015
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
3038
] | 1 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)"
] | [
3
] | 1 | true | Domain | Oxidoreductase AcuF-like, C2H2 type zinc-finger | Oxidoreductase AcuF-like, C2H2 type zinc-finger | Znf-C2H2_AcuF | 8 |
IPR058926 | 58,926 | YmzB-like | YmzB-like | Family | 330 | false | false | This entry represents Uncharacterized protein YmzB from Bacillus subtilis and similar proteins from bacillales. YmzB has a lipocalin-like fold similar to YojF. Members of this family are approximately 118 amino acids long. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25846"
] | [
"YmzB"
] | [
330
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacillota"
] | [
330
] | 1 | [] | [] | 0 | true | Family | YmzB-like | YmzB-like | YmzB-like | 2 |
IPR058927 | 58,927 | Membrane associated OB-fold-like protein | OB_2TM | Family | 242 | false | false | This entry represents a family of uncharacterised proteins found in halobacteria. Proteins in this family are predicted to have two transmembrane α-helices: one at the N terminus and one at the C terminus. Within these helices resides a 5 stranded β-barrel resembling the OB fold. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26045"
] | [
"OB_2TM_halo"
] | [
242
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Methanobacteriota"
] | [
242
] | 1 | [] | [] | 0 | true | Family | Membrane associated OB-fold-like protein | Membrane associated OB-fold-like protein | OB_2TM | 6 |
IPR058928 | 58,928 | Type VII secretion system extracellular protein C | EsxC | Family | 199 | false | false | This entry represents Type VII secretion system extracellular protein C (EsxC), a secreted substrate of the Staphylococcus aureus Type VII Secretion System (T7SS). EsxC plays an important role in bacterial membrane integrity and modulates membrane fluidity [ , ]. Deletion of esxC increases bacterial sensitivity to memb... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26323"
] | [
"EsxC"
] | [
199
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00044259",
"PUB00055111",
"PUB00161226"
] | [
"15657139",
"18554323",
"32908165"
] | [
"EsxA and EsxB are secreted by an ESAT-6-like system that is required for the pathogenesis of Staphylococcus aureus infections.",
"EsaC substrate for the ESAT-6 secretion pathway and its role in persistent infections of Staphylococcus aureus.",
"The type VII secretion system protects Staphylococcus aureus again... | [
2005,
2008,
2020
] | 3 | [] | [] | 0 | 0 | null | [
"Bacilli"
] | [
199
] | 1 | [] | [] | 0 | true | Family | Type VII secretion system extracellular protein C | Type VII secretion system extracellular protein C | EsxC | 6 |
IPR058929 | 58,929 | Ig-like domain, halobacteria | Ig_halo | Domain | 373 | false | false | This entry represents an Ig-like domains found in a group of uncharacterised proteins from halobacteria. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25942"
] | [
"Ig_halo"
] | [
373
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Actinomycetota",
"Stenosarchaea group"
] | [
2,
371
] | 2 | [] | [] | 0 | true | Domain | Ig-like domain, halobacteria | Ig-like domain, halobacteria | Ig_halo | 3 |
IPR058930 | 58,930 | YwzD | YwzD | Family | 281 | false | false | This entry represents a small family of proteins from bacillales that includes B.subtilis YwzD. This short protein is predicted to form a helical hairpin structure. The function of the members of this family is not known. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26162"
] | [
"YwzD"
] | [
281
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacillales"
] | [
281
] | 1 | [] | [] | 0 | true | Family | YwzD | YwzD | YwzD | 8 |
IPR058931 | 58,931 | SnoaL-like domain 6 | SnoaL_6 | Domain | 213 | false | false | This entry represents a domain from a family of uncharacterised proteins from ascomycetes. Proteins containing this domain are typically around 180-200 amino acids in length. This domain belongs to the NTF2-like superfamily, characterised by a partial β-barrel structure with α helices enclosing a solvent-accessible cav... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26528"
] | [
"SnoaL_6"
] | [
213
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Dikarya"
] | [
213
] | 1 | [] | [] | 0 | true | Domain | SnoaL-like domain 6 | SnoaL-like domain 6 | SnoaL_6 | 5 |
IPR058933 | 58,933 | YMC020W-like, alpha/beta hydrolase domain | YMC020W-like_ab_hydrolase | Domain | 1,916 | false | false | This entry represents the α/β hydrolase domain in a group of uncharacterised fungal proteins, including YMC020W from Saccharomyces cerevisiae. This domain is predicted to show a core structure composed of a central β-sheet consisting of 5-8 strands, connected by α-helices to form an α/β/α sandwich [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26147"
] | [
"AB_HYDROLASE_YMC0-YMC35"
] | [
1916
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00043472"
] | [
"14681380"
] | [
"ESTHER, the database of the alpha/beta-hydrolase fold superfamily of proteins."
] | [
2004
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1916
] | 1 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)"
] | [
1,
1
] | 2 | true | Domain | YMC020W-like, alpha/beta hydrolase domain | YMC020W-like, alpha/beta hydrolase domain | YMC020W-like_ab_hydrolase | 4 |
IPR058934 | 58,934 | YMC020W-like | YMC020W-like | Family | 1,942 | false | false | This entry represents a group of uncharacterised fungal proteins, including YMC020W from Saccharomyces cerevisiae [ ]. Members of this family contain , which is predicted to show an α/β hydrolase fold with a core structure composed of a central β-sheet consisting of 5-8 strands, connected by α-helices to form an α/β/α ... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR47349"
] | [
""
] | [
1942
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00043472"
] | [
"14681380"
] | [
"ESTHER, the database of the alpha/beta-hydrolase fold superfamily of proteins."
] | [
2004
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1942
] | 1 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)"
] | [
1,
1
] | 2 | true | Family | YMC020W-like | YMC020W-like | YMC020W-like | 5 |
IPR058935 | 58,935 | At4g15545-like, C-terminal domain | At4g15545-like_C | Domain | 2,014 | false | false | This domain is found at the C-terminal end of Uncharacterized protein At4g15545 from Arabidopsis thaliana and similar proteins mainly found in plants. This domain is predicted to fold into a bundle of four short α-helices. At4g15545 (named NAIP1) a specialised ER body component and is though to play a role in plant res... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25972"
] | [
"At4g15545_C"
] | [
2014
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00161681"
] | [
"30770459"
] | [
"A Family of NAI2-Interacting Proteins in the Biogenesis of the ER Body and Related Structures."
] | [
2019
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
2014
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
8,
15,
33
] | 3 | true | Domain | At4g15545-like, C-terminal domain | At4g15545-like, C-terminal domain | At4g15545-like_C | 3 |
IPR058936 | 58,936 | At4g15545-like | At4g15545-like | Family | 2,186 | false | false | This entry represents Uncharacterized protein At4g15545 from Arabidopsis thaliana and similar proteins mainly found in plants. Members of this family contain . At4g15545 (named NAIP1) a specialised ER body component and is though to play a role in plant responses to environmental conditions [ ]. | [
"GO:0080119"
] | [
"ER body organization"
] | [
"biological_process"
] | 1 | [
"PANTHER"
] | [
"PTHR47383"
] | [
""
] | [
2186
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00161681"
] | [
"30770459"
] | [
"A Family of NAI2-Interacting Proteins in the Biogenesis of the ER Body and Related Structures."
] | [
2019
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
2186
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
9,
14,
52
] | 3 | true | Family | At4g15545-like | At4g15545-like | At4g15545-like | 9 |
IPR058937 | 58,937 | Hsps-like, putative, alpha-crystallin-like domain | ACL_Hsps-like_put | Domain | 1,609 | false | false | This entry describes the alpha-crystallin-like domain in putative Heat shock proteins (Hsps) mostly found in plants. Hsps are small stress induced proteins with monomeric masses between 12-43 kDa, whose common feature is the alpha-crystallin domain. Hsps are generally active as large oligomers consisting of multiple su... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26144"
] | [
"ACL_Hsps-like"
] | [
1609
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00087792",
"PUB00087815"
] | [
"11875128",
"10950306"
] | [
"Alpha-crystallin-type heat shock proteins: socializing minichaperones in the context of a multichaperone network.",
"Structure and function of small heat shock/alpha-crystallin proteins: established concepts and emerging ideas."
] | [
2002,
2000
] | 2 | [] | [] | 0 | 0 | null | [
"Streptophyta"
] | [
1609
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
13,
9,
14
] | 3 | true | Domain | Hsps-like, putative, alpha-crystallin-like domain | Hsps-like, putative, alpha-crystallin-like domain | ACL_Hsps-like_put | 4 |
IPR058938 | 58,938 | Ribonuclease 3, central domain, two antiparallel helical region | Helical_CED_Drosha | Domain | 2,250 | false | false | This entry represents a region of the central domain (CED) of human Ribonuclease 3 (Drosha) and similar animal sequences. Drosha is a double-stranded RNA-specific endoribonuclease that is involved in the initial step of microRNA (miRNA) biogenesis. It is a component of the microprocessor complex required to process pri... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26050"
] | [
"Helical_CED_Drosha"
] | [
2250
] | 1 | [
"EC",
"REACTOME"
] | [
"3.1.26.3",
"R-HSA-203927"
] | [
"EC:3.1.26.3",
"REACTOME:R-HSA-203927"
] | 2 | [
"6lxd",
"6lxe",
"6v5b",
"6v5c",
"9asm",
"9asn",
"9aso",
"9asp",
"9asq"
] | 9 | [
"PUB00096059",
"PUB00096062",
"PUB00107808",
"PUB00161257",
"PUB00161260"
] | [
"14508493",
"10948199",
"15574589",
"32220645",
"29784949"
] | [
"The nuclear RNase III Drosha initiates microRNA processing.",
"Human RNase III is a 160-kDa protein involved in preribosomal RNA processing.",
"The Drosha-DGCR8 complex in primary microRNA processing.",
"Structural Basis for pri-miRNA Recognition by Drosha.",
"Neuronal activity regulates DROSHA via autopha... | [
2003,
2000,
2004,
2020,
2018
] | 5 | [] | [] | 0 | 0 | null | [
"Metazoa"
] | [
2250
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
1,
2,
2,
7,
3
] | 6 | true | Domain | Ribonuclease 3, central domain, two antiparallel helical region | Ribonuclease 3, central domain, two antiparallel helical region | Helical_CED_Drosha | 1 |
IPR058940 | 58,940 | Small ribosomal subunit protein mS26, fungi | mS26_fungi | Family | 1,252 | false | false | This entry represents the yeast Small ribosomal subunit protein mS26 and related fungal proteins. mS26 is a component of the small subunit of mitochondrial ribosomes, specifically the 37S small subunit [ ]. It contributes to the assembly and function of the ribosome. mS26 plays a critical role in mitochondrial protein ... | [
"GO:0003735"
] | [
"structural constituent of ribosome"
] | [
"molecular_function"
] | 1 | [
"PFAM",
"CDD"
] | [
"PF26163",
"cd23703"
] | [
"mS26",
"mS26_PET12"
] | [
1203,
1175
] | 2 | [] | [] | [] | 0 | [
"5mrc",
"5mre",
"5mrf",
"6yw5",
"6ywe",
"6ywx",
"6ywy",
"8d8j",
"8d8k",
"8d8l",
"8om2",
"8om3",
"8om4"
] | 13 | [
"PUB00098057",
"PUB00158252"
] | [
"28154081",
"2167435"
] | [
"The structure of the yeast mitochondrial ribosome.",
"A novel small-subunit ribosomal protein of yeast mitochondria that interacts functionally with an mRNA-specific translational activator."
] | [
2017,
1990
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1252
] | 1 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)"
] | [
1,
1
] | 2 | true | Family | Small ribosomal subunit protein mS26, fungi | Small ribosomal subunit protein mS26, fungi | mS26_fungi | 5 |
IPR058941 | 58,941 | AT3G52170-like, helix-turn-helix domain | HTH_AT3G52170-like | Domain | 1,309 | false | false | This entry represents a helix-turn-helix (HTH) DNA-binding domain found at the N-terminal region of plant proteins including Arabidopsis thaliana AT3G52170 ( ) and AT5G58210 ( ). These proteins are annotated as DNA binding proteins and the domain is likely involved in transcriptional regulation. The HTH motif is a comm... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25896"
] | [
"HTH_AT3G52170"
] | [
1309
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Streptophytina"
] | [
1309
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
10,
7,
18
] | 3 | true | Domain | AT3G52170-like, helix-turn-helix domain | AT3G52170-like, helix-turn-helix domain | HTH_AT3G52170-like | 5 |
IPR058942 | 58,942 | AT3G52170-like | AT3G52170-like | Family | 1,476 | false | false | This entry represents a family of uncharacterised plant proteins that have an helix-turn-helix domain ( ), including Arabidopsis thaliana AT3G52170 ( ) and AT5G58210 ( ). These proteins are annotated as DNA binding proteins and are are thought to be involved in transcriptional regulation. | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR34568"
] | [
""
] | [
1476
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Embryophyta"
] | [
1476
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
18,
7,
20
] | 3 | true | Family | AT3G52170-like | AT3G52170-like | AT3G52170-like | 9 |
IPR058943 | 58,943 | GT-1/4-like, C-terminal domain | GT-1/4_C | Domain | 1,008 | false | false | This domain is found twice at the C-terminal end of Trihelix transcription factor GT-1 and GT-4 from Arabidopsis thaliana and similar plant proteins. GT-1 binds specifically to the core DNA sequence 5'-GGTTAA-3' and may act as a molecular switch in response to light signals [ , , ]. This domain is predicted to adopt an... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26214"
] | [
"Ubiquitin_GT-1"
] | [
1008
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00066593",
"PUB00128626",
"PUB00161511"
] | [
"15044016",
"10437822",
"7866025"
] | [
"Analysis of GT-3a identifies a distinct subgroup of trihelix DNA-binding transcription factors in Arabidopsis.",
"Modulation of GT-1 DNA-binding activity by calcium-dependent phosphorylation.",
"Molecular dissection of GT-1 from Arabidopsis."
] | [
2004,
1999,
1994
] | 3 | [] | [] | 0 | 0 | null | [
"Streptophytina"
] | [
1008
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
8,
2,
6
] | 3 | true | Domain | GT-1/4-like, C-terminal domain | GT-1/4-like, C-terminal domain | GT-1/4_C | 7 |
IPR058944 | 58,944 | Histidine racemase | CntK-like | Family | 530 | false | false | This entry represents a group of bacterial histidine racemases, including CntK from Staphylococcus aureus and HisR from Fusobacterium nucleatum. These proteins are cofactor-independent histidine racemases that catalyse the conversion of L-histidine to D-histidine [ , ]. CntK is involved in the first step of staphylopin... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26317"
] | [
"CntK_N"
] | [
530
] | 1 | [
"EC",
"METACYC"
] | [
"5.1.1.24",
"PWY-8007"
] | [
"EC:5.1.1.24",
"METACYC:PWY-8007"
] | 2 | [
"6jis",
"6jiw",
"6l4l",
"9cr1",
"9cr6"
] | 5 | [
"PUB00161177",
"PUB00161178",
"PUB00161179",
"PUB00161180"
] | [
"31129210",
"37106798",
"39424140",
"33115405"
] | [
"Crystal structure of CntK, the cofactor-independent histidine racemase in staphylopine-mediated metal acquisition of Staphylococcus aureus.",
"Overview of <i>Yersinia pestis</i> Metallophores: Yersiniabactin and Yersinopine.",
"Discovery, characterization, and structure of a cofactor-independent histidine race... | [
2019,
2023,
2024,
2020
] | 4 | [] | [
"IPR058945"
] | 0 | 1 | 0 | [
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
518,
5,
7
] | 3 | [] | [] | 0 | true | Family | Histidine racemase | Histidine racemase | CntK-like | 7 |
IPR058945 | 58,945 | Histidine racemase CntK | CntK | Family | 70 | false | false | This entry represents a group of Staphylococcus histidine racemases, including CntK from Staphylococcus aureus, a cofactor-independent histidine racemases that catalyse the conversion of L-histidine to D-histidine [ ]. CntK is involved in the first step of the biosynthesis of staphylopine, a metallophore involved in th... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF033599"
] | [
"His_racem_CntK"
] | [
70
] | 1 | [] | [] | [] | 0 | [
"6jis",
"6jiw",
"6l4l"
] | 3 | [
"PUB00081137",
"PUB00161177",
"PUB00161178",
"PUB00161179",
"PUB00161180"
] | [
"27230378",
"31129210",
"37106798",
"39424140",
"33115405"
] | [
"Biosynthesis of a broad-spectrum nicotianamine-like metallophore in Staphylococcus aureus.",
"Crystal structure of CntK, the cofactor-independent histidine racemase in staphylopine-mediated metal acquisition of Staphylococcus aureus.",
"Overview of <i>Yersinia pestis</i> Metallophores: Yersiniabactin and Yersi... | [
2016,
2019,
2023,
2024,
2020
] | 5 | [
"IPR058944"
] | [] | 1 | 0 | 1 | [
"Staphylococcaceae"
] | [
70
] | 1 | [] | [] | 0 | true | Family | Histidine racemase CntK | Histidine racemase CntK | CntK | 4 |
IPR058946 | 58,946 | ZNF451, C-terminal C2H2 type zinc fingers | Zf-C2H2_ZNF451_C | Domain | 945 | false | false | This entry represents a domain is found in the C-terminal of E3 SUMO-protein ligase ZNF451 and similar proteins from vertebrates. This domain consists of two consecutive C2H2 type zinc fingers, whose 4 β-strands are arranged in an antiparallel β-sheet. ZNF451 is a key enzyme involved in the sumoylation process, exhibit... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23107"
] | [
"Zf-C2H2_ZNF451_C"
] | [
945
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00117493",
"PUB00120713",
"PUB00120714"
] | [
"26524494",
"24324267",
"26524493"
] | [
"Structural basis for catalytic activation by the human ZNF451 SUMO E3 ligase.",
"Zinc finger protein 451 is a novel Smad corepressor in transforming growth factor-β signaling.",
"A new vertebrate SUMO enzyme family reveals insights into SUMO-chain assembly."
] | [
2015,
2014,
2015
] | 3 | [] | [] | 0 | 0 | null | [
"Opisthokonta"
] | [
945
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
5,
4
] | 3 | true | Domain | ZNF451, C-terminal C2H2 type zinc fingers | ZNF451, C-terminal C2H2 type zinc fingers | Zf-C2H2_ZNF451_C | 8 |
IPR058947 | 58,947 | ZNF451, second C2H2 type zinc finger | Zf-C2H2_ZNF451_2nd | Domain | 887 | false | false | This entry represents the second C2H2 type zinc finger found in E3 SUMO-protein ligase ZNF451 and similar proteins from vertebrates. ZNF451 is a key enzyme involved in the sumoylation process, exhibiting a preference for SUMO2 and SUMO3 over SUMO1. It facilitates the UBE2I/UBC9-mediated sumoylation of target proteins, ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23102"
] | [
"Zf-C2H2_ZNF451_2nd"
] | [
887
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00117493",
"PUB00120713",
"PUB00120714"
] | [
"26524494",
"24324267",
"26524493"
] | [
"Structural basis for catalytic activation by the human ZNF451 SUMO E3 ligase.",
"Zinc finger protein 451 is a novel Smad corepressor in transforming growth factor-β signaling.",
"A new vertebrate SUMO enzyme family reveals insights into SUMO-chain assembly."
] | [
2015,
2014,
2015
] | 3 | [] | [] | 0 | 0 | null | [
"Bilateria"
] | [
887
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
3,
4
] | 3 | true | Domain | ZNF451, second C2H2 type zinc finger | ZNF451, second C2H2 type zinc finger | Zf-C2H2_ZNF451_2nd | 9 |
IPR058949 | 58,949 | ZNF451, first C2H2 type zinc finger | Zf-C2H2_ZNF451_1st | Domain | 1,249 | false | false | This entry represents a C2H2 type zinc finger found in the N-terminal of E3 SUMO-protein ligase ZNF451 and similar proteins mainly found in vertebrates. ZNF451 is a key enzyme involved in the sumoylation process, exhibiting a preference for SUMO2 and SUMO3 over SUMO1. It facilitates the UBE2I/UBC9-mediated sumoylation ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23101"
] | [
"Zf-C2H2_ZNF451_1st"
] | [
1249
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00117493",
"PUB00120713",
"PUB00120714"
] | [
"26524494",
"24324267",
"26524493"
] | [
"Structural basis for catalytic activation by the human ZNF451 SUMO E3 ligase.",
"Zinc finger protein 451 is a novel Smad corepressor in transforming growth factor-β signaling.",
"A new vertebrate SUMO enzyme family reveals insights into SUMO-chain assembly."
] | [
2015,
2014,
2015
] | 3 | [] | [] | 0 | 0 | null | [
"Opisthokonta"
] | [
1249
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
4,
3,
3,
4
] | 4 | true | Domain | ZNF451, first C2H2 type zinc finger | ZNF451, first C2H2 type zinc finger | Zf-C2H2_ZNF451_1st | 4 |
IPR058950 | 58,950 | ZNF451, fifth C2H2 type zinc finger | Zf-C2H2_ZNF451_5th | Domain | 1,196 | false | false | This entry represents the fifth C2H2 type zinc finger found in E3 SUMO-protein ligase ZNF451 and similar proteins from vertebrates. ZNF451 is a key enzyme involved in the sumoylation process, exhibiting a preference for SUMO2 and SUMO3 over SUMO1. It facilitates the UBE2I/UBC9-mediated sumoylation of target proteins, p... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23103"
] | [
"Zf-C2H2_ZNF451_5th"
] | [
1196
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00117493",
"PUB00120713",
"PUB00120714"
] | [
"26524494",
"24324267",
"26524493"
] | [
"Structural basis for catalytic activation by the human ZNF451 SUMO E3 ligase.",
"Zinc finger protein 451 is a novel Smad corepressor in transforming growth factor-β signaling.",
"A new vertebrate SUMO enzyme family reveals insights into SUMO-chain assembly."
] | [
2015,
2014,
2015
] | 3 | [] | [] | 0 | 0 | null | [
"Vertebrata"
] | [
1196
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
4,
3,
3,
4
] | 4 | true | Domain | ZNF451, fifth C2H2 type zinc finger | ZNF451, fifth C2H2 type zinc finger | Zf-C2H2_ZNF451_5th | 8 |
IPR058951 | 58,951 | Rad26/CSB-like, winged helix DNA-binding domain | WHD_Rad26_CSB-like | Domain | 2,706 | false | false | This entry represents a DNA-binding winged helix domain (WHD) found in the transcription-coupled repair protein Rad26/CSB and similar eukaryotic proteins. This domain is critical for enabling Rad26/CSB to bind to DNA and stalled RNA polymerase II in transcription-coupled repair [ ]. Rad26 (in yeast), its human ortholog... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25875"
] | [
"WHD_Rad26_CSB"
] | [
2706
] | 1 | [
"EC",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"3.6.4.-",
"PWY-7250",
"R-HSA-427389",
"R-HSA-5250924",
"R-HSA-6781823",
"R-HSA-6781827",
"R-HSA-6782135",
"R-HSA-6782210",
"R-HSA-73762",
"R-MMU-5250924",
"R-MMU-6781823",
"R-MMU-6782135",
"R-MMU-6782210",
"R-MMU-73762",
"R-SCE-6781823",
"R-SCE-6782135",
"R-SCE-6782210"
] | [
"EC:3.6.4.-",
"METACYC:PWY-7250",
"REACTOME:R-HSA-427389",
"REACTOME:R-HSA-5250924",
"REACTOME:R-HSA-6781823",
"REACTOME:R-HSA-6781827",
"REACTOME:R-HSA-6782135",
"REACTOME:R-HSA-6782210",
"REACTOME:R-HSA-73762",
"REACTOME:R-MMU-5250924",
"REACTOME:R-MMU-6781823",
"REACTOME:R-MMU-6782135",
"... | 17 | [
"5vvr",
"6a6i",
"7oo3",
"7oob",
"7oop",
"7opc",
"7opd",
"8b3d",
"8b3f",
"8he5",
"8tvy",
"9bz0",
"9er2",
"9fd2",
"9hwg"
] | 15 | [
"PUB00092515",
"PUB00112397",
"PUB00142765",
"PUB00146701",
"PUB00146715",
"PUB00146717",
"PUB00146719",
"PUB00147963",
"PUB00154275",
"PUB00161542",
"PUB00161682",
"PUB00161683",
"PUB00161684",
"PUB00161685"
] | [
"11859374",
"16246722",
"29168508",
"30753618",
"25820262",
"26620705",
"29203878",
"32355176",
"34526721",
"37120012",
"19894250",
"38600235",
"38600236",
"7957102"
] | [
"A Rad26-Def1 complex coordinates repair and RNA pol II proteolysis in response to DNA damage.",
"Recognition of RNA polymerase II and transcription bubbles by XPG, CSB, and TFIIH: insights for transcription-coupled repair and Cockayne Syndrome.",
"Structural basis for the initiation of eukaryotic transcription... | [
2002,
2005,
2017,
2019,
2015,
2016,
2017,
2020,
2021,
2023,
2010,
2024,
2024,
1994
] | 14 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
2706
] | 1 | [
"Arabidopsis thaliana",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Zea mays"
] | [
6,
1,
5,
2,
2,
3,
1,
7
] | 8 | true | Domain | Rad26/CSB-like, winged helix DNA-binding domain | Rad26/CSB-like, winged helix DNA-binding domain | WHD_Rad26_CSB-like | 6 |
IPR058952 | 58,952 | CFAP47-like, immunoglobulin-like domain | Ig_CFAP47 | Domain | 1,054 | false | false | This immunoglobulin-like (Ig-like) domain is found towards the C-terminal end of human Cilia- and flagella-associated protein 47 (CFAP47), which plays a role in flagellar formation and sperm motility [ ]. Members of this group are mainly found in animals. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26579"
] | [
"Ig_CFAP47"
] | [
1054
] | 1 | [] | [] | [] | 0 | [
"7n6g",
"7sqc",
"9ijj"
] | 3 | [
"PUB00155585"
] | [
"33472045"
] | [
"Deleterious variants in X-linked CFAP47 induce asthenoteratozoospermia and primary male infertility."
] | [
2021
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1054
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
1,
5
] | 3 | true | Domain | CFAP47-like, immunoglobulin-like domain | CFAP47-like, immunoglobulin-like domain | Ig_CFAP47 | 4 |
IPR058953 | 58,953 | Pectate disaccharide-lyase-like, N-terminal domain | PelX-like_N | Domain | 638 | false | false | This entry represents the N-terminal β supersandwich domain of pectate disaccharide-lyase from Dickeya chrysanthemi (PelX, ), also known as exopolygalacturonate lyase. This enzyme catalyses the exo-cleavage of pectate and contributes to pectate catabolism in bacteria. The enzyme requires calcium ions for activity and h... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25849"
] | [
"PelX_N"
] | [
638
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00161400"
] | [
"2254266"
] | [
"Molecular cloning of the structural gene for exopolygalacturonate lyase from Erwinia chrysanthemi EC16 and characterization of the enzyme product."
] | [
1990
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"human gut metagenome"
] | [
637,
1
] | 2 | [] | [] | 0 | true | Domain | Pectate disaccharide-lyase-like, N-terminal domain | Pectate disaccharide-lyase-like, N-terminal domain | PelX-like_N | 7 |
IPR058954 | 58,954 | SMAX1-like, AAA+ ATPase lid domain | AAA_lid_SMAX1 | Domain | 2,118 | false | false | This AAA+ ATPase lid domain is found at the C-terminal end of Protein SUPPRESSOR OF MAX2 1 from Arabidopsis thaliana (SMAX1) and similar plant sequences. SMAX1 is thought to be a component of a transcriptional corepressor complex that acts downstream of MAX2 to negatively regulate karrikins /strigolactone responses [ ,... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26587"
] | [
"AAA_lid_SMAX1"
] | [
2118
] | 1 | [] | [] | [] | 0 | [
"9kkx",
"9kld",
"9klv"
] | 3 | [
"PUB00161108",
"PUB00161109",
"PUB00161110",
"PUB00161111",
"PUB00161112",
"PUB00161113",
"PUB00161114"
] | [
"26546447",
"23893171",
"26546446",
"26754282",
"24336200",
"24336215",
"28809396"
] | [
"SMAX1-LIKE/D53 Family Members Enable Distinct MAX2-Dependent Responses to Strigolactones and Karrikins in Arabidopsis.",
"SUPPRESSOR OF MORE AXILLARY GROWTH2 1 controls seed germination and seedling development in Arabidopsis.",
"Strigolactone Signaling in Arabidopsis Regulates Shoot Development by Targeting D... | [
2015,
2013,
2015,
2016,
2013,
2013,
2017
] | 7 | [] | [] | 0 | 0 | null | [
"Embryophyta"
] | [
2118
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
22,
6,
9
] | 3 | true | Domain | SMAX1-like, AAA+ ATPase lid domain | SMAX1-like, AAA+ ATPase lid domain | AAA_lid_SMAX1 | 7 |
IPR058955 | 58,955 | GAPS4b, N-terminal domain | GAPS4b_N | Domain | 190 | false | false | This entry represents the N-terminal helical domain of the GAPS4b protein from Vibrio furnissii ( ), which is the second component of the GAPS4 anti-phage defence system found within mobile Gamma-Mobile-Trio (GMT) genomic islands [ ]. The helical N-terminal domain likely plays a role in protein-protein interactions, po... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26110"
] | [
"GAPS4b_N"
] | [
190
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00161243"
] | [
"39443754"
] | [
"Gamma-Mobile-Trio systems are mobile elements rich in bacterial defensive and offensive tools."
] | [
2024
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"metagenomes"
] | [
186,
4
] | 2 | [] | [] | 0 | true | Domain | GAPS4b, N-terminal domain | GAPS4b, N-terminal domain | GAPS4b_N | 8 |
IPR058956 | 58,956 | Magnetosome protein MamC | MamC | Family | 308 | false | false | This protein family includes Magnetosome protein MamC from Magnetococcus marinus and similar bacterial proteins. MamC is involved in the regulation of magnetite crystal size and shape, playing a crucial role in magnetosome formation [ , ]. The lumenal magnetite interacting component (MIC) within these proteins is key t... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26373"
] | [
"MamC"
] | [
308
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00105539",
"PUB00161330",
"PUB00161331",
"PUB00161332",
"PUB00161333"
] | [
"17965152",
"25874532",
"26970040",
"24961165",
"30405554"
] | [
"The major magnetosome proteins MamGFDC are not essential for magnetite biomineralization in Magnetospirillum gryphiswaldense but regulate the size of magnetosome crystals.",
"Size control of in vitro synthesized magnetite crystals by the MamC protein of Magnetococcus marinus strain MC-1.",
"Structure-function ... | [
2008,
2015,
2016,
2014,
2018
] | 5 | [] | [] | 0 | 0 | null | [
"Bacteria",
"ecological metagenomes"
] | [
306,
2
] | 2 | [] | [] | 0 | true | Family | Magnetosome protein MamC | Magnetosome protein MamC | MamC | 8 |
IPR058957 | 58,957 | Putative peptidase inhibitor domain | Peptidase_inhib_put_dom | Domain | 175 | false | false | This entry represents a domain found in a group of uncharacterised proteins found in halobacteria and some actinomycetes species. This domain covers the whole length of the protein in many members. The structure shows similarity to the prodomain of the Tk-subtilisin from the hyperthermophilic archaeon Thermococcus koda... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26036"
] | [
"Peptidase_inhib_put"
] | [
175
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Actinomycetes",
"Halobacteriales",
"Orbilia ellipsospora"
] | [
39,
135,
1
] | 3 | [] | [] | 0 | true | Domain | Putative peptidase inhibitor domain | Putative peptidase inhibitor domain | Peptidase_inhib_put_dom | 5 |
IPR058958 | 58,958 | CI111, double-psi beta-barrel domain | DPBB_CI111 | Domain | 706 | false | false | This entry represents a double-psi β barrel (DPBB) domain found in CI111 protein from Arabidopsis thaliana and related plant proteins. The DPBB domain is a six-stranded β barrel with a pseudo-twofold axis where two psi-loop structures are arranged symmetrically [ ]. This fold is shared by several protein families inclu... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26429"
] | [
"DPBB_CI111"
] | [
706
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00011777"
] | [
"10368289"
] | [
"A six-stranded double-psi beta barrel is shared by several protein superfamilies."
] | [
1999
] | 1 | [] | [] | 0 | 0 | null | [
"Streptophyta"
] | [
706
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
5,
3,
12
] | 3 | true | Domain | CI111, double-psi beta-barrel domain | CI111, double-psi beta-barrel domain | DPBB_CI111 | 9 |
IPR058959 | 58,959 | Protein of unknown function DUF8157, C-terminal domain | DUF8157_C | Domain | 396 | false | false | This entry represents the C-terminal domain from a family of uncharacterised proteins from archaea, predominantly from halobacteria. The proteins typically range from 450 to 550 amino acids in length. Proteins in this entry have a methyltransferase domain centrally located and at the N-terminal end. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26487"
] | [
"DUF8157_C"
] | [
396
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Stenosarchaea group",
"ecological metagenomes"
] | [
394,
2
] | 2 | [] | [] | 0 | true | Domain | Protein of unknown function DUF8157, C-terminal domain | Protein of unknown function DUF8157, C-terminal domain | DUF8157_C | 5 |
IPR058960 | 58,960 | Ctg-1-like, C-terminal domain | Ctg-1-like_C | Domain | 655 | false | false | This domain is found at the C-terminal end of Protein ctg-1 from Caenorhabditis elegans and similar proteins mainly found in nematodes. Ctg-1 is a probable vesicle trafficking protein that functions in uterine cells to promote basement membrane (BM) mobility and BM gap formation during tissue remodelling [ ]. This doma... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25883"
] | [
"F28H7_8_C"
] | [
655
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00153721"
] | [
"27661254"
] | [
"Boundary cells restrict dystroglycan trafficking to control basement membrane sliding during tissue remodeling."
] | [
2016
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
655
] | 1 | [
"Caenorhabditis elegans"
] | [
8
] | 1 | true | Domain | Ctg-1-like, C-terminal domain | Ctg-1-like, C-terminal domain | Ctg-1-like_C | 1 |
IPR058961 | 58,961 | YafT | YafT | Family | 394 | false | false | This entry represents the uncharacterised lipoprotein YafT from Escherichia coli and similar bacterial sequences. The proteins in this family are anchored to the cell membrane via lipid modification of an N-terminal cysteine residue. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25851"
] | [
"YafT"
] | [
394
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"metagenomes"
] | [
389,
5
] | 2 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | YafT | YafT | YafT | 8 |
IPR058962 | 58,962 | Protein of unknown function DUF8108-like, N-terminal domain | DUF8108_N | Domain | 251 | false | false | This entry represents the N-terminal domain from a family of uncharacterised proteins from halophilic archaea and some bacterial species. Proteins in this family are typically between 150 and 350 amino acids in length. They are predicted to be membrane-associated, as suggested by the presence of two transmembrane helic... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26438"
] | [
"DUF8108_N"
] | [
251
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Methanobacteriota",
"Viruses"
] | [
66,
180,
5
] | 3 | [] | [] | 0 | true | Domain | Protein of unknown function DUF8108-like, N-terminal domain | Protein of unknown function DUF8108-like, N-terminal domain | DUF8108_N | 8 |
IPR058963 | 58,963 | Protein of unknown function DUF8108, central domain | DUF8108_M | Domain | 82 | false | false | This entry represents a the central transmembrane domain from a family of uncharacterised proteins from halophilic archaea. Proteins in this family are typically between 150 and 350 amino acids in length. They are predicted to be membrane-associated, as suggested by the presence of two transmembrane helices represented... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26440"
] | [
"DUF8108_M"
] | [
82
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Actinomycetes",
"Halobacteriales"
] | [
2,
80
] | 2 | [] | [] | 0 | true | Domain | Protein of unknown function DUF8108, central domain | Protein of unknown function DUF8108, central domain | DUF8108_M | 1 |
IPR058964 | 58,964 | Cap2, central linker domain | Cap2_linker | Domain | 229 | false | false | This domain is found centrally located in the ATP-dependent ubiquitin transferase-like protein Cap2 (Cap2) from Enterobacter hormaechei and related prokaryotic proteins. Bacteria encode evolutionary predecessors of cGAS called cGAS/DncV-like nucleotidyltransferases 2 (CD-NTases), which detect bacteriophage infection an... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26398"
] | [
"Cap2_linker"
] | [
229
] | 1 | [] | [] | [] | 0 | [
"7to3",
"7tqd"
] | 2 | [
"PUB00161169"
] | [
"36755092"
] | [
"An E1-E2 fusion protein primes antiviral immune signalling in bacteria."
] | [
2023
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Methanobacteriota"
] | [
208,
21
] | 2 | [] | [] | 0 | true | Domain | Cap2, central linker domain | Cap2, central linker domain | Cap2_linker | 5 |
IPR058965 | 58,965 | Styrene oxide isomerase/Hydroxylaminobenzene mutase-like | SOI/HabA-like | Family | 590 | false | false | This entry represents Styrene oxide isomerase from Pseudomonas fluorescens (SOI, EC 5.3.99.7), Hydroxylaminobenzene mutase HabA from Ectopseudomonas oleovorans and similar proteins from bacteria and some eukaryotic species. SOI is a membrane-bound enzyme involved in bacterial styrene degradation. It catalyses the Meinw... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26512"
] | [
"SOI"
] | [
590
] | 1 | [] | [] | [] | 0 | [
"8pnu",
"8pnv"
] | 2 | [
"PUB00122405",
"PUB00161473",
"PUB00161474",
"PUB00161475",
"PUB00161689"
] | [
"9172343",
"38744914",
"22504818",
"27396882",
"10877793"
] | [
"Sequencing and functional analysis of styrene catabolism genes from Pseudomonas fluorescens ST.",
"Structural basis of the Meinwald rearrangement catalysed by styrene oxide isomerase.",
"Styrene oxide isomerase of Rhodococcus opacus 1CP, a highly stable and considerably active enzyme.",
"Characterization of ... | [
1997,
2024,
2012,
1997,
2000
] | 5 | [] | [
"IPR054803"
] | 0 | 1 | 0 | [
"Bacteria",
"Eukaryota",
"ecological metagenomes"
] | [
519,
68,
3
] | 3 | [] | [] | 0 | true | Family | Styrene oxide isomerase/Hydroxylaminobenzene mutase-like | Styrene oxide isomerase/Hydroxylaminobenzene mutase-like | SOI/HabA-like | 3 |
IPR058966 | 58,966 | MJECL33-like | MJECL33-like | Family | 96 | false | false | This family represents a set of uncharacterised bacterial proteins related to Methanocaldococcus jannaschii MJECL33. These proteins are found sporadically in bacteria and archaeal species. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25924"
] | [
"MJECL33"
] | [
96
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"ecological metagenomes"
] | [
44,
47,
5
] | 3 | [] | [] | 0 | true | Family | MJECL33-like | MJECL33-like | MJECL33-like | 9 |
IPR058967 | 58,967 | Hfq-like protein | Hfq-like | Family | 130 | false | false | This entry represents a family of uncharacterised halobacterial proteins that have a structure related to the Hfq protein. Structure prediction suggests these proteins form homooligomeric ring complexes. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26264"
] | [
"Halo_Hfq_like"
] | [
130
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Halobacteriales"
] | [
130
] | 1 | [] | [] | 0 | true | Family | Hfq-like protein | Hfq-like protein | Hfq-like | 1 |
IPR058968 | 58,968 | SPbeta prophage-derived uncharacterized protein YoqH-like | YoqH-like | Family | 185 | false | false | This entry represents a family of proteins from firmicutes, including the uncharacterised YoqH protein found in the B. subtilis genome as part of the SPbeta prophage. This domain adopts an Ig-like β sandwich fold. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26349"
] | [
"YoqH"
] | [
185
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacillota",
"Bacillus phage SPbeta",
"mine drainage metagenome"
] | [
183,
1,
1
] | 3 | [] | [] | 0 | true | Family | SPbeta prophage-derived uncharacterized protein YoqH-like | SPbeta prophage-derived uncharacterized protein YoqH-like | YoqH-like | 6 |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.