interpro_id string | interpro_numeric_id int64 | name string | short_name string | entry_type string | protein_count int64 | is_llm bool | is_llm_reviewed bool | abstract string | go_ids list | go_terms list | go_categories list | go_count int64 | member_databases list | member_accessions list | member_names list | member_protein_counts list | member_count int64 | external_databases list | external_accessions list | external_xrefs list | external_xref_count int64 | pdb_ids list | structure_count int64 | publication_ids list | pubmed_ids list | publication_titles list | publication_years list | publication_count int64 | parent_ids list | child_ids list | parent_count int64 | child_count int64 | tree_depth float64 | taxonomy_names list | taxonomy_protein_counts list | taxonomy_count int64 | key_species_names list | key_species_protein_counts list | key_species_count int64 | in_entry_list bool | entry_list_type string | entry_list_name string | names_dat_name string | short_names_dat_name string | split_bucket int64 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
IPR059081 | 59,081 | Proline-rich transmembrane protein 3/4 | PRRT3-4 | Domain | 2,159 | false | false | This domain is found in human Proline-rich transmembrane protein 3 (PRRT3) and 4 (PRRT4) and similar animal proteins. This domain is predicted to adopt an all-α configuration. The specific function of these proteins has not been elucidated yet. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25987"
] | [
"PRRT3"
] | [
2159
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Methanolapillus africanus"
] | [
2158,
1
] | 2 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
6,
2,
3,
3,
3
] | 5 | true | Domain | Proline-rich transmembrane protein 3/4 | Proline-rich transmembrane protein 3/4 | PRRT3-4 | 1 |
IPR059083 | 59,083 | Uncharacterized GPI-anchored protein At5g19230-like domain | At5g19230_dom | Domain | 1,325 | false | false | This domain is found in several uncharacterised GPI-anchored proteins from Arabidopsis thaliana, whose specific function is unknown. These include At5g19230, At3g06035, At5g19240 and At5g19250. This domain is predicted to show an α-β configuration. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25884"
] | [
"At5g19230"
] | [
1325
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Embryophyta"
] | [
1325
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
17,
2,
10
] | 3 | true | Domain | Uncharacterized GPI-anchored protein At5g19230-like domain | Uncharacterized GPI-anchored protein At5g19230-like domain | At5g19230_dom | 7 |
IPR059085 | 59,085 | Calmodulin-dependent glutamylase SidJ, N-terminal domain | SidJ_N | Domain | 48 | false | false | This entry represents the N-terminal domain of SidJ. Calmodulin-dependent glutamylase SidJ (SidJ) proteins function as calmodulin-dependent glutamylases. These proteins facilitate the attachment of glutamate moieties to specific catalytic residues on target proteins such as SdeA, SdeB, SdeC, and SidE. This modification... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26375"
] | [
"SidJ_CaM_N"
] | [
48
] | 1 | [] | [] | [] | 0 | [
"6k4k",
"6k4l",
"6k4r",
"6oqq",
"6plm",
"6s5t",
"7mir",
"7mis",
"7ppo",
"7pqe"
] | 10 | [
"PUB00105393",
"PUB00161470",
"PUB00161471",
"PUB00161472"
] | [
"31123136",
"28497808",
"31330532",
"31330531"
] | [
"Bacterial pseudokinase catalyzes protein polyglutamylation to inhibit the SidE-family ubiquitin ligases.",
"A unique deubiquitinase that deconjugates phosphoribosyl-linked protein ubiquitination.",
"Inhibition of bacterial ubiquitin ligases by SidJ-calmodulin catalysed glutamylation.",
"Regulation of phospho... | [
2019,
2017,
2019,
2019
] | 4 | [] | [] | 0 | 0 | null | [
"Legionella"
] | [
48
] | 1 | [] | [] | 0 | true | Domain | Calmodulin-dependent glutamylase SidJ, N-terminal domain | Calmodulin-dependent glutamylase SidJ, N-terminal domain | SidJ_N | 9 |
IPR059086 | 59,086 | Uncharacterized protein MT0599 | MT0599 | Domain | 40 | false | false | This entry represents Uncharacterized protein MT0599 which was first identified in Mycobacterium tuberculosis. MT0599 is a member of the dormancy regulon and is induced in response to reduced oxygen tension (hypoxia) and low levels of nitric oxide (NO), suggesting a possible role in mycobacterial dormancy or persistenc... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25859"
] | [
"MT0599"
] | [
40
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00161696"
] | [
"12953092"
] | [
"Inhibition of respiration by nitric oxide induces a Mycobacterium tuberculosis dormancy program."
] | [
2003
] | 1 | [] | [] | 0 | 0 | null | [
"Mycobacteriales"
] | [
40
] | 1 | [] | [] | 0 | true | Domain | Uncharacterized protein MT0599 | Uncharacterized protein MT0599 | MT0599 | 7 |
IPR059087 | 59,087 | Mitochondrial RNA binding complex 1 subunit | RESC10 | Domain | 45 | false | false | This domain is found in RESC10 ( ). RESC10 is predicted to adopt an all-helical structure with a disordered N-terminal region (of about 118 amino acids) that is predicted with low confidence. The rest of the protein is predicted with high confidence and shows a helical repeat structure that resembles proteins containin... | [] | [] | [] | 0 | [
"PFAM",
"CDD"
] | [
"PF26179",
"cd23738"
] | [
"RESC10",
"RESC10"
] | [
45,
40
] | 2 | [] | [] | [] | 0 | [
"8fnc",
"8fnf",
"8fni",
"8fnk"
] | 4 | [
"PUB00157639",
"PUB00160174"
] | [
"33677542",
"37410820"
] | [
"Trypanosome RNAEditing Substrate Binding Complex integrity and function depends on the upstream action of RESC10.",
"Structural basis of gRNA stabilization and mRNA recognition in trypanosomal RNA editing."
] | [
2021,
2023
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
45
] | 1 | [] | [] | 0 | true | Domain | Mitochondrial RNA binding complex 1 subunit | Mitochondrial RNA binding complex 1 subunit | RESC10 | 5 |
IPR059088 | 59,088 | Malate synthase H, C-terminal domain | MSH_C | Domain | 167 | false | false | This entry represents the C-terminal domain of malate synthase H (MSH) isoform found in halophilic archaea. The C-terminal domain caps the active site of the protein and contributes the catalytic base [ ]. This domain is smaller than the corresponding domains in malate synthase isoforms A and G. The MSH isoform lacks a... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25918"
] | [
"MSH_C"
] | [
167
] | 1 | [] | [] | [] | 0 | [
"3oyx",
"3oyz",
"3pug",
"5tao"
] | 4 | [
"PUB00058821",
"PUB00070126",
"PUB00089819",
"PUB00106323"
] | [
"21569248",
"21252347",
"9738442",
"11513957"
] | [
"Crystal structures of a halophilic archaeal malate synthase from Haloferax volcanii and comparisons with isoforms A and G.",
"A methylaspartate cycle in haloarchaea.",
"Operation of glyoxylate cycle in halophilic archaea: presence of malate synthase and isocitrate lyase in Haloferax volcanii.",
"Sequencing, ... | [
2011,
2011,
1998,
2001
] | 4 | [] | [] | 0 | 0 | null | [
"Halobacteria"
] | [
167
] | 1 | [] | [] | 0 | true | Domain | Malate synthase H, C-terminal domain | Malate synthase H, C-terminal domain | MSH_C | 7 |
IPR059089 | 59,089 | Kazrin, N-terminal domain | Kazrin_N | Domain | 2,674 | false | false | This domain is found N-terminal in human Kazrin. This domain is predicted to adopt an α-helical configuration. Kazrin is a periplakin-interacting protein associated with desmosomes and the keratinocyte plasma membrane [ ]. In Xenopus embryos, loss of kazrin causes defects in cell adhesion that affect axial elongation, ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25986"
] | [
"Kazrin"
] | [
2674
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-6809371",
"R-MMU-6809371",
"R-RNO-6809371"
] | [
"REACTOME:R-HSA-6809371",
"REACTOME:R-MMU-6809371",
"REACTOME:R-RNO-6809371"
] | 3 | [] | 0 | [
"PUB00087385",
"PUB00087386",
"PUB00087387"
] | [
"15337775",
"18498100",
"28373753"
] | [
"Kazrin, a novel periplakin-interacting protein associated with desmosomes and the keratinocyte plasma membrane.",
"KazrinA is required for axial elongation and epidermal integrity in Xenopus tropicalis.",
"Upregulation of kazrin F by miR-186 suppresses apoptosis but promotes epithelial-mesenchymal transition t... | [
2004,
2008,
2017
] | 3 | [] | [] | 0 | 0 | null | [
"Bacillales",
"Metazoa",
"Thermofilum adornatum",
"viral metagenome"
] | [
2,
2670,
1,
1
] | 4 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
20,
5,
3,
6,
4
] | 5 | true | Domain | Kazrin, N-terminal domain | Kazrin, N-terminal domain | Kazrin_N | 8 |
IPR059090 | 59,090 | Alanine--tRNA ligase, helical bundle domain | ALA1_helical | Domain | 2,168 | false | false | This domain is found in Alanine--tRNA ligase, mitochondrial from Saccharomyces cerevisiae (ALA1), which catalyses the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). This domain is predicted to adopt an α... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26023"
] | [
"ALA1"
] | [
2168
] | 1 | [
"EC"
] | [
"6.1.1.7"
] | [
"EC:6.1.1.7"
] | 1 | [] | 0 | [
"PUB00161120",
"PUB00161121"
] | [
"7761427",
"16928688"
] | [
"Wide cross-species aminoacyl-tRNA synthetase replacement in vivo: yeast cytoplasmic alanine enzyme replaced by human polymyositis serum antigen.",
"Cross-species and cross-compartmental aminoacylation of isoaccepting tRNAs by a class II tRNA synthetase."
] | [
1995,
2006
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
2168
] | 1 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)",
"Zea mays"
] | [
1,
4,
1,
1,
12
] | 5 | true | Domain | Alanine--tRNA ligase, helical bundle domain | Alanine--tRNA ligase, helical bundle domain | ALA1_helical | 3 |
IPR059091 | 59,091 | YhiD, C-terminal ACT domain | ACT_YhiD_C | Domain | 126 | false | false | This entry represents the ACT domain, a small molecule binding module with a characteristic β-α-β-β-α-β fold. Members of this clan typically form dimers or higher-order oligomers, with ligand binding often occurring at the domain interfaces. These domains function as regulatory modules that bind amino acids or other sm... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26539"
] | [
"ACT_YhiD_C"
] | [
126
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00070393"
] | [
"19798051"
] | [
"Mg(2+)-dependent gating of bacterial MgtE channel underlies Mg(2+) homeostasis."
] | [
2009
] | 1 | [] | [] | 0 | 0 | null | [
"Pseudomonadati",
"Trichuris trichiura",
"metagenomes"
] | [
123,
1,
2
] | 3 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Domain | YhiD, C-terminal ACT domain | YhiD, C-terminal ACT domain | ACT_YhiD_C | 5 |
IPR059093 | 59,093 | Alsin, helical array domain | HA_Alsin | Domain | 1,937 | false | false | This domain is found in human Alsin and related proteins. This domain precedes the VPS domain ( ) found at the C-terminal. Alsin functions as a guanine nucleotide exchange factor (GEF) for Rho family GTPases, particularly Rac1, in addition to its role as a Rab5 GEF. It contains a DH domain and a PH domain ( ). This dua... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26202"
] | [
"HA_Alsin"
] | [
1937
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-DME-8876198",
"R-DME-9013149",
"R-HSA-8876198",
"R-HSA-9013149",
"R-MMU-8876198",
"R-MMU-9013149",
"R-RNO-8876198",
"R-RNO-9013149"
] | [
"REACTOME:R-DME-8876198",
"REACTOME:R-DME-9013149",
"REACTOME:R-HSA-8876198",
"REACTOME:R-HSA-9013149",
"REACTOME:R-MMU-8876198",
"REACTOME:R-MMU-9013149",
"REACTOME:R-RNO-8876198",
"REACTOME:R-RNO-9013149"
] | 8 | [] | 0 | [
"PUB00160482",
"PUB00160483",
"PUB00160604"
] | [
"15033976",
"25309324",
"24702731"
] | [
"Alsin is a Rab5 and Rac1 guanine nucleotide exchange factor.",
"The emerging role of guanine nucleotide exchange factors in ALS and other neurodegenerative diseases.",
"Age-dependent deterioration of locomotion in Drosophila melanogaster deficient in the homologue of amyotrophic lateral sclerosis 2."
] | [
2004,
2014,
2014
] | 3 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota"
] | [
3,
1934
] | 2 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
9,
1,
13,
2,
4
] | 5 | true | Domain | Alsin, helical array domain | Alsin, helical array domain | HA_Alsin | 9 |
IPR059094 | 59,094 | PH domain-like, eukaryotic | PH_36_euk | Domain | 21 | false | false | This entry represents a small set of PH-like domains found in a sporadic range of eukaryotic organisms. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26278"
] | [
"PH_36"
] | [
21
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
21
] | 1 | [] | [] | 0 | true | Domain | PH domain-like, eukaryotic | PH domain-like, eukaryotic | PH_36_euk | 7 |
IPR059095 | 59,095 | C2H2-domain containing protein, second zinc finger domain | Znf_C2H2_17_2nd | Domain | 2,604 | false | false | This entry represents the second C2H2 zinc finger domain in putative C2H2 domain-containing proteins found in fungi. These proteins contain a disordered N-terminal region, followed by two domains ( and ) and an α-helical C-terminal domain. This entry also includes putative Rrn9 domain-containing protein. C2H2 zinc fing... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26176"
] | [
"zf_C2H2_17_2"
] | [
2604
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00161554",
"PUB00161555",
"PUB00161556"
] | [
"25258363",
"27596598",
"29294058"
] | [
"Wilms tumor protein recognizes 5-carboxylcytosine within a specific DNA sequence.",
"Denys-Drash syndrome associated WT1 glutamine 369 mutants have altered sequence-preferences and altered responses to epigenetic modifications.",
"Role for first zinc finger of WT1 in DNA sequence specificity: Denys-Drash syndr... | [
2014,
2016,
2018
] | 3 | [
"IPR013087"
] | [] | 1 | 0 | 1 | [
"Eukaryota"
] | [
2604
] | 1 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)"
] | [
3
] | 1 | true | Domain | C2H2-domain containing protein, second zinc finger domain | C2H2-domain containing protein, second zinc finger domain | Znf_C2H2_17_2nd | 8 |
IPR059096 | 59,096 | Partial PH domain, tunicates | Partial_PH_tunicates | Domain | 5 | false | false | This entry represents a domain found in some tunicates. It shows structural similarity to one β-sheet of a PH domain. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26564"
] | [
"pPH"
] | [
5
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Tunicata"
] | [
5
] | 1 | [] | [] | 0 | true | Domain | Partial PH domain, tunicates | Partial PH domain, tunicates | Partial_PH_tunicates | 9 |
IPR059097 | 59,097 | LNAD(+)--arginine ADP-ribosyltransferase Lart1 | Lart1_ADPRT | Family | 35 | false | false | This entry represents NAD(+)--arginine ADP-ribosyltransferase Lart1 (Lart1_ADPRT), a ADP-ribosyltransferase that specifically targets NAD(+)-dependent glutamate dehydrogenase (GDH) enzymes in fungi and protists, which are common hosts of Legionella. These proteins function by modifying a conserved arginine residue with... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26393"
] | [
"Lart1_ADPRT"
] | [
35
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00161313"
] | [
"33476647"
] | [
"A Legionella effector ADP-ribosyltransferase inactivates glutamate dehydrogenase."
] | [
2021
] | 1 | [] | [] | 0 | 0 | null | [
"Legionellaceae"
] | [
35
] | 1 | [] | [] | 0 | true | Family | LNAD(+)--arginine ADP-ribosyltransferase Lart1 | LNAD(+)--arginine ADP-ribosyltransferase Lart1 | Lart1_ADPRT | 5 |
IPR059098 | 59,098 | DNA replication licensing factor MCM2-like, winged-helix domain | WHD_MCM2 | Domain | 3,159 | false | false | This is the winged-helix (WH) domain found at the C-terminal end of human DNA replication licensing factor MCM2 and similar eukaryotic proteins. MCM2 is a component of the MCM2-7 complex, the replicative helicase essential for DNA replication initiation and elongation in eukaryotic cells, and a core component of the CD... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23669"
] | [
"WHD_MCM2"
] | [
3159
] | 1 | [
"EC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"3.6.4.12",
"R-DME-176187",
"R-DME-68867",
"R-DME-68949",
"R-DME-68962",
"R-DME-69052",
"R-HSA-176187",
"R-HSA-176974",
"R-HSA-68867",
"R-HSA-68949",
"R-HSA-68962",
"R-HSA-69052",
"R-HSA-9825895",
"R-MMU-176187",
"R-MMU-68867",
"R-MMU-68949",
"R-MMU-68962",
"R-MMU-69052",
"R-XTR-... | [
"EC:3.6.4.12",
"REACTOME:R-DME-176187",
"REACTOME:R-DME-68867",
"REACTOME:R-DME-68949",
"REACTOME:R-DME-68962",
"REACTOME:R-DME-69052",
"REACTOME:R-HSA-176187",
"REACTOME:R-HSA-176974",
"REACTOME:R-HSA-68867",
"REACTOME:R-HSA-68949",
"REACTOME:R-HSA-68962",
"REACTOME:R-HSA-69052",
"REACTOME:... | 22 | [
"6raw",
"6rax",
"6ray",
"6raz",
"6xtx",
"6xty",
"7pfo",
"7plo",
"7w1y",
"7w68",
"8b9d",
"8ouw",
"8q6o",
"8q6p",
"8rwv",
"8s09",
"8s0a",
"8s0b",
"8s0d",
"8s0e",
"8s0f",
"8w0e",
"8w0f",
"8w0g",
"8w0i",
"9c6g",
"9caq",
"9e2z"
] | 28 | [
"PUB00154055",
"PUB00154917",
"PUB00154918",
"PUB00155918"
] | [
"32453425",
"34694004",
"34700328",
"31484077"
] | [
"CryoEM structures of human CMG-ATPγS-DNA and CMG-AND-1 complexes.",
"Structure of a human replisome shows the organisation and interactions of a DNA replication machine.",
"A conserved mechanism for regulating replisome disassembly in eukaryotes.",
"Molecular Basis for ATP-Hydrolysis-Driven DNA Translocation... | [
2020,
2021,
2021,
2019
] | 4 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
3159
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
5,
1,
1,
1,
6,
3,
1,
1,
10
] | 9 | true | Domain | DNA replication licensing factor MCM2-like, winged-helix domain | DNA replication licensing factor MCM2-like, winged-helix domain | WHD_MCM2 | 3 |
IPR059099 | 59,099 | GMEB1/2/Spe-44-like domain | GMEB1/2/Spe-44_dom | Domain | 2,250 | false | false | This domain is found in a group of transcription regulators from animals, including Spe-44 from Caenorhabditis elegans, and human Glucocorticoid modulatory element-binding protein 1/2 (GMEB1/2). Spe-44 is a transcription factor which controls spermatogenesis and sperm cell fate by regulation of sperm gene expression [ ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25892"
] | [
"Spe-44"
] | [
2250
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00029548",
"PUB00056637",
"PUB00097262"
] | [
"12702733",
"10894151",
"22570621"
] | [
"Crystal structure and nuclear magnetic resonance analyses of the SAND domain from glucocorticoid modulatory element binding protein-1 reveals deoxyribonucleic acid and zinc binding regions.",
"Properties of the glucocorticoid modulatory element binding proteins GMEB-1 and -2: potential new modifiers of glucocort... | [
2003,
2000,
2012
] | 3 | [] | [] | 0 | 0 | null | [
"Bilateria"
] | [
2250
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
7,
5,
4,
11
] | 5 | true | Domain | GMEB1/2/Spe-44-like domain | GMEB1/2/Spe-44-like domain | GMEB1/2/Spe-44_dom | 4 |
IPR059100 | 59,100 | Bacterial TSP3 repeat | TSP3_bac | Repeat | 5,209 | false | false | This entry contains a novel bacterial thrombospondin type 3 repeat which differs from the typical consensus by containing a glutamate in place of one of the calcium binding aspartate residues. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF18884"
] | [
"TSP3_bac"
] | [
5209
] | 1 | [
"EC"
] | [
"4.2.2.2"
] | [
"EC:4.2.2.2"
] | 1 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
634,
4184,
176,
2,
213
] | 5 | [] | [] | 0 | true | Repeat | Bacterial TSP3 repeat | Bacterial TSP3 repeat | TSP3_bac | 9 |
IPR059101 | 59,101 | NFACT, RNA binding domain 2 | NFACT-R_2 | Domain | 1,612 | false | false | This entry represents the RNA binding domain of NFACT-R, which found in bacteria fused to the ThiI domain as a variant of the canonical tRNA 4-thiouridylation pathway [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF18297"
] | [
"NFACT-R_2"
] | [
1612
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00091027"
] | [
"24646681"
] | [
"A highly conserved family of domains related to the DNA-glycosylase fold helps predict multiple novel pathways for RNA modifications."
] | [
2014
] | 1 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
62,
1437,
14,
99
] | 4 | [] | [] | 0 | true | Domain | NFACT, RNA binding domain 2 | NFACT, RNA binding domain 2 | NFACT-R_2 | 4 |
IPR059102 | 59,102 | PHF7/G2E3-like, PHD zinc finger domain | PHD_PHF7/G2E3-like | Domain | 2,779 | false | false | This PHD zinc finger domain is found in human E3 ubiquitin-protein ligase PHF7 and G2/M phase-specific E3 ubiquitin-protein ligase (G2E3),its fly orthologue Pineapple eye protein (PIE) and similar animal E3 ubiquitin-protein ligases. PHF7 ubiquitinates histone H4 [ ]. G2E3 accepts ubiquitin from an E2 ubiquitin-conjuga... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26054"
] | [
"PHD_G2E3"
] | [
2779
] | 1 | [
"EC"
] | [
"2.3.2"
] | [
"EC:2.3.2"
] | 1 | [
"1weq",
"8jwj",
"8jwu"
] | 3 | [
"PUB00092233",
"PUB00092234",
"PUB00092235",
"PUB00092236",
"PUB00092237",
"PUB00161409",
"PUB00161410",
"PUB00161411",
"PUB00161697"
] | [
"11829468",
"18511420",
"17239372",
"22894908",
"22595675",
"14704172",
"22413088",
"37993255",
"32726616"
] | [
"NYD-SP6, a novel gene potentially involved in regulating testicular development/spermatogenesis.",
"G2E3 is a dual function ubiquitin ligase required for early embryonic development.",
"G2E3 is a nucleo-cytoplasmic shuttling protein with DNA damage responsive localization.",
"Genome wide identification of pr... | [
2002,
2008,
2007,
2012,
2012,
2003,
2012,
2023,
2020
] | 9 | [
"IPR001965"
] | [] | 1 | 0 | 1 | [
"Eukaryota"
] | [
2779
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
5,
1,
14,
6,
11
] | 5 | true | Domain | PHF7/G2E3-like, PHD zinc finger domain | PHF7/G2E3-like, PHD zinc finger domain | PHD_PHF7/G2E3-like | 1 |
IPR059103 | 59,103 | FixC-like, C-terminal domain | FixC-like_C | Domain | 3,283 | false | false | This entry represents the C-terminal domain of FixC from Escherichia coli and similar prokaryotic proteins. The ETF-QO/FixC family is involved in electron transfer processes [ ]. Members of this group are likely to accept electrons from specific partners, such as YdiQ/YdiR or FixA/FixB, and subsequently reduce quinones... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26311"
] | [
"ETF-QO_FixC_C"
] | [
3283
] | 1 | [] | [] | [] | 0 | [
"7koe"
] | 1 | [
"PUB00089910"
] | [
"15386115"
] | [
"The electron transfer flavoprotein fixABCX gene products from Azospirillum brasilense show a NifA-dependent promoter regulation."
] | [
2004
] | 1 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"unclassified sequences"
] | [
85,
3150,
48
] | 3 | [
"Escherichia coli (strain K12)"
] | [
2
] | 1 | true | Domain | FixC-like, C-terminal domain | FixC-like, C-terminal domain | FixC-like_C | 9 |
IPR059104 | 59,104 | EIPR1-like, beta-propeller | Beta-prop_EIPR1-like | Domain | 4,237 | false | false | This entry represents the β-propeller domain found at the N-terminal end in EARP and GARP complex-interacting protein 1 (EIPR1) and similar eukaryotic proteins. EIPR1 is a component of the endosomal retrieval machinery, binding to both the Endosome-Associated Recycling Protein (EARP) and Golgi-Associated Retrograde Pro... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23609"
] | [
"Beta-prop_EIPR1"
] | [
4237
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-DDI-9639288",
"R-SPO-3214815",
"R-SPO-3214847",
"R-SPO-3214858",
"R-SPO-8951664",
"R-SPO-9764725"
] | [
"REACTOME:R-DDI-9639288",
"REACTOME:R-SPO-3214815",
"REACTOME:R-SPO-3214847",
"REACTOME:R-SPO-3214858",
"REACTOME:R-SPO-8951664",
"REACTOME:R-SPO-9764725"
] | 6 | [
"5wjc",
"6s1l",
"6s1r",
"6s29"
] | 4 | [
"PUB00090818",
"PUB00090820",
"PUB00155525"
] | [
"27440922",
"20525848",
"31721635"
] | [
"TSSC1 is novel component of the endosomal retrieval machinery.",
"DWA1 and DWA2, two Arabidopsis DWD protein components of CUL4-based E3 ligases, act together as negative regulators in ABA signal transduction.",
"EIPR1 controls dense-core vesicle cargo retention and EARP complex localization in insulin-secreti... | [
2016,
2010,
2020
] | 3 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
4237
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)",
"Zea mays"
] | [
13,
1,
5,
1,
8,
3,
7,
3,
1,
17
] | 10 | true | Domain | EIPR1-like, beta-propeller | EIPR1-like, beta-propeller | Beta-prop_EIPR1-like | 3 |
IPR059106 | 59,106 | MalT-like, winged helix domain | WHD_MalT | Domain | 11,830 | false | false | This entry represents the winged helix-turn-helix (wHTH) domain found in the MalT transcriptional regulator, in Serine/threonine-protein kinase PknK and HTH-type transcriptional regulator AlkS from bacteria. MalT contains one HTH LuxR-type DNA-binding domain. MalT activates the maltose regulon, a set of operons involve... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25873"
] | [
"WHD_MalT"
] | [
11830
] | 1 | [] | [] | [] | 0 | [
"8bob"
] | 1 | [
"PUB00161531",
"PUB00161532",
"PUB00161533",
"PUB00161534",
"PUB00161535",
"PUB00161536",
"PUB00161537",
"PUB00161538"
] | [
"7040340",
"3305511",
"2524384",
"2538630",
"19251699",
"20522497",
"22661693",
"22740025"
] | [
"Role of the catabolite activator protein in the maltose regulon of Escherichia coli.",
"Purification and properties of the MalT protein, the transcription activator of the Escherichia coli maltose regulon.",
"MalT, the regulatory protein of the Escherichia coli maltose system, is an ATP-dependent transcription... | [
1982,
1987,
1989,
1989,
2009,
2010,
2012,
2012
] | 8 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Halobacteriales",
"unclassified sequences"
] | [
11706,
7,
25,
92
] | 4 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Domain | MalT-like, winged helix domain | MalT-like, winged helix domain | WHD_MalT | 7 |
IPR059107 | 59,107 | Mso1, membrane-polarising domain | Mso1_C | Domain | 66 | false | false | This C-terminal region of Mso1 assists in targeting Sec1 to the sites of polarised membrane transport, the SNARES and Sec4 [ ]. Mso1p is a component of the secretory vesicle docking complex whose function is closely associated with that of Sec1p. It is a small hydrophilic protein that is enriched in the microsomal memb... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF14477"
] | [
"Mso1_C"
] | [
66
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00067508",
"PUB00067509",
"PUB00067510",
"PUB00067511"
] | [
"9207091",
"16006618",
"20181830",
"21119007"
] | [
"Mso1p: a yeast protein that functions in secretion and interacts physically and genetically with Sec1p.",
"A gene truncation strategy generating N- and C-terminal deletion variants of proteins for functional studies: mapping of the Sec1p binding domain in yeast Mso1p by a Mu in vitro transposition-based approach... | [
1997,
2005,
2010,
2011
] | 4 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
66
] | 1 | [
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
1,
1
] | 2 | true | Domain | Mso1, membrane-polarising domain | Mso1, membrane-polarising domain | Mso1_C | 8 |
IPR059109 | 59,109 | Apolipoprotein N-acyltransferase, integral membrane domain, campylobacterales | Lnt_membrane_dom | Domain | 471 | false | false | This entry represents the N-terminal integral membrane domain of the Lnt proteins predominately found in Campylobacterales. This domain contains seven transmembrane α helices. Apolipoprotein N-acyltransferase (Lnt) proteins predominately found in Campylobacterales are responsible for catalysing the phospholipid-depende... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26365"
] | [
"ApoNAT_membrane"
] | [
471
] | 1 | [
"EC",
"METACYC"
] | [
"2.3.1.269",
"PWY-7884"
] | [
"EC:2.3.1.269",
"METACYC:PWY-7884"
] | 2 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Pseudomonadati",
"ecological metagenomes"
] | [
454,
17
] | 2 | [] | [] | 0 | true | Domain | Apolipoprotein N-acyltransferase, integral membrane domain, campylobacterales | Apolipoprotein N-acyltransferase, integral membrane domain, campylobacterales | Lnt_membrane_dom | 1 |
IPR059111 | 59,111 | Trm72, C-terminal ARM-like repeat | Trm732_C | Domain | 1,132 | false | false | This entry represents the C-terminal ARM repeat region of tRNA (32-2'-O)-methyltransferase regulator trm732 from Schizosaccharomyces pombe and similar proteins from ascomycetes. Together with methyltransferase Trm7, Trm732 methylates the 2'-O-ribose of nucleotides at position 32 of the anticodon loop of substrate tRNAs... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26523"
] | [
"Trm732_C"
] | [
1132
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00098322"
] | [
"25404562"
] | [
"Conservation of an intricate circuit for crucial modifications of the tRNAPhe anticodon loop in eukaryotes."
] | [
2015
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1132
] | 1 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
1,
1
] | 2 | true | Domain | Trm72, C-terminal ARM-like repeat | Trm72, C-terminal ARM-like repeat | Trm732_C | 6 |
IPR059112 | 59,112 | Sulfate transporter CysZ/Etoposide-induced protein 2.4 | CysZ/EI24 | Family | 15,804 | false | false | This family contains a number of eukaryotic etoposide-induced 2.4 (EI24) proteins approximately 350 residues long as well as bacterial CysZ proteins (formerly known as DUF540). In cells treated with the cytotoxic drug etoposide, ei24 is induced by p53 and may play an important role in negative cell growth control by fu... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF07264"
] | [
"EI24"
] | [
15804
] | 1 | [] | [] | [] | 0 | [
"3tx3",
"6d79",
"6d9z"
] | 3 | [
"PUB00013075",
"PUB00013076",
"PUB00070599",
"PUB00074289",
"PUB00095245",
"PUB00153921"
] | [
"8649819",
"10594026",
"20550938",
"24657232",
"15781622",
"29792261"
] | [
"Identification and cloning of EI24, a gene induced by p53 in etoposide-treated cells.",
"ei24, a p53 response gene involved in growth suppression and apoptosis.",
"C. elegans screen identifies autophagy genes specific to multicellular organisms.",
"The Escherichia coli CysZ is a pH dependent sulfate transpor... | [
1996,
2000,
2010,
2014,
2005,
2018
] | 6 | [] | [
"IPR050480"
] | 0 | 1 | 0 | [
"Bacteria",
"Eukaryota",
"Sylvanvirus sp.",
"unclassified sequences"
] | [
10767,
4936,
1,
100
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
7,
1,
1,
1,
1,
3,
2,
1,
2,
4,
8
] | 11 | true | Family | Sulfate transporter CysZ/Etoposide-induced protein 2.4 | Sulfate transporter CysZ/Etoposide-induced protein 2.4 | CysZ/EI24 | 3 |
IPR059113 | 59,113 | Putative zinc-ribbon domain 3 | Znf_ribbon_3 | Domain | 1,850 | false | false | This entry represents a putative zinc ribbon domain. This domain is found in diverse proteins mainly from bacteria. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF13248"
] | [
"Zn_ribbon_3"
] | [
1850
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"metagenomes"
] | [
112,
1648,
13,
7,
70
] | 5 | [] | [] | 0 | true | Domain | Putative zinc-ribbon domain 3 | Putative zinc-ribbon domain 3 | Znf_ribbon_3 | 6 |
IPR059114 | 59,114 | NUDT9-like, N-terminal domain | NUDT9_N | Domain | 3,912 | false | false | This domain is found towards the N-terminal end of ADP-ribose pyrophosphatase, mitochondrial (NUDT9) and towards the C-terminal of Transient receptor potential cation channel subfamily M member 2 (TRPM2) and similar animal sequences. This domain, which has an α-β configuration, is often found associated to a catalytic ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25969"
] | [
"NUDT9_N"
] | [
3912
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-CEL-2393930",
"R-CEL-3295583",
"R-HSA-2393930",
"R-HSA-3295583",
"R-HSA-6798695",
"R-MMU-2393930",
"R-MMU-3295583",
"R-MMU-6798695",
"R-RNO-2393930",
"R-RNO-3295583",
"R-RNO-6798695"
] | [
"REACTOME:R-CEL-2393930",
"REACTOME:R-CEL-3295583",
"REACTOME:R-HSA-2393930",
"REACTOME:R-HSA-3295583",
"REACTOME:R-HSA-6798695",
"REACTOME:R-MMU-2393930",
"REACTOME:R-MMU-3295583",
"REACTOME:R-MMU-6798695",
"REACTOME:R-RNO-2393930",
"REACTOME:R-RNO-3295583",
"REACTOME:R-RNO-6798695"
] | 11 | [
"1q33",
"1qvj",
"6co7",
"6mix",
"6miz",
"6mj2",
"6puo",
"6pur",
"6pus",
"6puu",
"7vq1",
"8e6q",
"8e6r",
"8e6s",
"8e6t",
"8e6u",
"8e6v",
"8sr7",
"8sr8",
"8sr9",
"8sra",
"8srb",
"8src",
"8srd",
"8sre",
"8srf",
"8srg",
"8srh",
"8sri",
"9jje",
"9jjf"
] | 31 | [
"PUB00030096",
"PUB00160201",
"PUB00160452",
"PUB00161373",
"PUB00161374",
"PUB00161375",
"PUB00161376",
"PUB00161377",
"PUB00161378",
"PUB00161379",
"PUB00161380",
"PUB00161381",
"PUB00161698",
"PUB00161700",
"PUB00161701",
"PUB00161702",
"PUB00161703"
] | [
"12948489",
"31513012",
"28760991",
"11385575",
"25620041",
"27333281",
"28775320",
"29745897",
"11960981",
"31431622",
"30250252",
"30467180",
"20660597",
"27068538",
"27383051",
"34788616",
"37343711"
] | [
"The crystal structure and mutational analysis of human NUDT9.",
"Ligand recognition and gating mechanism through three ligand-binding sites of human TRPM2 channel.",
"Presumptive TRP channel CED-11 promotes cell volume decrease and facilitates degradation of apoptotic cells in <i>Caenorhabditis elegans</i>.",
... | [
2003,
2019,
2017,
2001,
2015,
2016,
2017,
2018,
2002,
2019,
2018,
2018,
2010,
2016,
2016,
2021,
2023
] | 17 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"organismal metagenomes"
] | [
51,
3859,
2
] | 3 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
1,
2,
11,
7,
6
] | 6 | true | Domain | NUDT9-like, N-terminal domain | NUDT9-like, N-terminal domain | NUDT9_N | 7 |
IPR059115 | 59,115 | Rib domain | Rib | Domain | 1,861 | false | false | The region featured in this entry is found repeated in a number of bacterial surface proteins, such as Rib ( ) and C protein alpha-antigen ( ). Rib domain-containing surface proteins are found associated with invasive strains and elicit protective immunity in animal models. Structures of single Rib domains of differing... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF08428"
] | [
"Rib"
] | [
1861
] | 1 | [] | [] | [] | 0 | [
"6s5x",
"6s5y",
"6s5z",
"6sx1",
"8pxc",
"8yk7",
"8yke"
] | 7 | [
"PUB00017753",
"PUB00161706",
"PUB00161707"
] | [
"8702550",
"31818940",
"39196706"
] | [
"Identification of a family of streptococcal surface proteins with extremely repetitive structure.",
"Defining the remarkable structural malleability of a bacterial surface protein Rib domain implicated in infection.",
"Crystal structure of the Rib domain of the cell-wall-anchored surface protein from Limosilac... | [
1996,
2019,
2024
] | 3 | [] | [] | 0 | 0 | null | [
"Bacteria",
"human gut metagenome"
] | [
1854,
7
] | 2 | [] | [] | 0 | true | Domain | Rib domain | Rib domain | Rib | 9 |
IPR059116 | 59,116 | ATP P2X receptor-like | P2X_receptor | Family | 9,394 | false | false | This entry represents all P2X receptors subtypes (P2X1 through P2X7), including five P2X-like proteins (P2XA-E) present in Dictyostelium discoideum and some P2X-like ion channels from green algae e.g. Ostreococcus tauri. P2X purinoceptors are cell membrane ion channels, gated by adenosine 5'-triphosphate (ATP) and othe... | [] | [] | [] | 0 | [
"PFAM",
"PANTHER"
] | [
"PF00864",
"PTHR10125"
] | [
"P2X_receptor",
""
] | [
9306,
9238
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-139853",
"R-BTA-418346",
"R-DDI-139853",
"R-DDI-418346",
"R-DDI-6798695",
"R-DDI-844456",
"R-DRE-139853",
"R-DRE-418346",
"R-HSA-139853",
"R-HSA-418346",
"R-HSA-6798695",
"R-HSA-844456",
"R-HSA-9660826",
"R-HSA-9856532",
"R-MMU-139853",
"R-MMU-418346",
"R-MMU-6798695",
"R-MM... | [
"REACTOME:R-BTA-139853",
"REACTOME:R-BTA-418346",
"REACTOME:R-DDI-139853",
"REACTOME:R-DDI-418346",
"REACTOME:R-DDI-6798695",
"REACTOME:R-DDI-844456",
"REACTOME:R-DRE-139853",
"REACTOME:R-DRE-418346",
"REACTOME:R-HSA-139853",
"REACTOME:R-HSA-418346",
"REACTOME:R-HSA-6798695",
"REACTOME:R-HSA-8... | 22 | [
"2rup",
"3h9v",
"3i5d",
"4dw0",
"4dw1",
"5f1c",
"5svj",
"5svk",
"5svl",
"5svm",
"5svp",
"5svq",
"5svr",
"5svs",
"5svt",
"5u1l",
"5u1u",
"5u1v",
"5u1w",
"5u1x",
"5u1y",
"5u2h",
"5wzy",
"5xw6",
"5yve",
"6ah4",
"6ah5",
"6u9v",
"6u9w",
"8jv5",
"8jv6",
"8jv7"... | 72 | [
"PUB00006451",
"PUB00007054",
"PUB00068520",
"PUB00100494",
"PUB00161708",
"PUB00161709",
"PUB00161710"
] | [
"10414359",
"12270951",
"19833731",
"29631184",
"23740252",
"18381285",
"19015952"
] | [
"Functional and molecular diversity of purinergic ion channel receptors.",
"Molecular physiology of P2X receptors.",
"Functional characterization of intracellular Dictyostelium discoideum P2X receptors.",
"Modulation of innate and adaptive immunity by P2X ion channels.",
"Functional properties of five Dicty... | [
1999,
2002,
2009,
2018,
2013,
2008,
2009
] | 7 | [] | [
"IPR001429"
] | 0 | 1 | 0 | [
"Eukaryota",
"Megaviricetes"
] | [
9390,
4
] | 2 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
22,
50,
37,
63
] | 4 | true | Family | ATP P2X receptor-like | ATP P2X receptor-like | P2X_receptor | 4 |
IPR059117 | 59,117 | APS kinase domain | APS_kinase_dom | Domain | 27,950 | false | false | This entry represents the APS kinase domain which is found, either standalone or in combination with other domains, in proteins with diverse enzymatic functions. The APS kinase domain is a critical part of the bifunctional enzyme PAPS synthase (PAPSS), which catalyses the formation of 3'-phosphoadenosine 5'-phosphosulf... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF01583"
] | [
"APS_kinase"
] | [
27950
] | 1 | [
"EC",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"2.7.1.25",
"PWY-5340",
"R-CEL-174362",
"R-HSA-174362",
"R-HSA-2408550",
"R-HSA-3560796",
"R-HSA-6802952",
"R-MMU-174362",
"R-MTU-936635",
"R-SCE-174362",
"R-SPO-174362"
] | [
"EC:2.7.1.25",
"METACYC:PWY-5340",
"REACTOME:R-CEL-174362",
"REACTOME:R-HSA-174362",
"REACTOME:R-HSA-2408550",
"REACTOME:R-HSA-3560796",
"REACTOME:R-HSA-6802952",
"REACTOME:R-MMU-174362",
"REACTOME:R-MTU-936635",
"REACTOME:R-SCE-174362",
"REACTOME:R-SPO-174362"
] | 11 | [
"1d6j",
"1i2d",
"1m7g",
"1m7h",
"1m8p",
"1x6v",
"1xjq",
"1xnj",
"2ax4",
"2gks",
"2ofw",
"2ofx",
"2pey",
"2pez",
"2yvu",
"3cr7",
"3cr8",
"3uie",
"4bzp",
"4bzq",
"4bzx",
"4fxp",
"4rfv",
"5cb6",
"5cb8",
"6b8v",
"6c6b",
"7yq0",
"7yq1",
"8a8h",
"8i1m",
"8i1n"... | 33 | [
"PUB00003028",
"PUB00032335",
"PUB00161711"
] | [
"9786849",
"15755455",
"26294763"
] | [
"Adenosine 5'-phosphosulfate kinase from Penicillium chrysogenum. site-directed mutagenesis at putative phosphoryl-accepting and ATP P-loop residues.",
"The crystal structure of human PAPS synthetase 1 reveals asymmetry in substrate binding.",
"Recapitulating the Structural Evolution of Redox Regulation in Aden... | [
1998,
2005,
2015
] | 3 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
191,
17426,
9888,
27,
418
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
15,
1,
4,
5,
1,
6,
7,
2,
9,
7,
2,
1,
38
] | 13 | true | Domain | APS kinase domain | APS kinase domain | APS_kinase_dom | 4 |
IPR059118 | 59,118 | PD-(D/E)XK nuclease-like domain, halobacteria | PDDEXK_dom_halobact | Domain | 35 | false | false | This entry represents a domain found in a group of putative nucleases found in halobacterial proteins. It is often found C-terminal to . | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26295"
] | [
"PDDEXK_17"
] | [
35
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Halobacteriales"
] | [
35
] | 1 | [] | [] | 0 | true | Domain | PD-(D/E)XK nuclease-like domain, halobacteria | PD-(D/E)XK nuclease-like domain, halobacteria | PDDEXK_dom_halobact | 6 |
IPR059119 | 59,119 | NTF2-like | NTF2-like | Family | 43 | false | false | This entry represents a family of uncharacterised proteins mainly found in Trypanosomatida that contain a domain that belongs to the NTF2-like superfamily, which is characterised by a partial β-barrel structure with α helices enclosing a solvent-accessible cavity. Proteins in this family are approximately 275-343 amino... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26532"
] | [
"NTF2_5"
] | [
43
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Metakinetoplastina"
] | [
43
] | 1 | [] | [] | 0 | true | Family | NTF2-like | NTF2-like | NTF2-like | 9 |
IPR059120 | 59,120 | Cullin-like, alpha+beta domain | Cullin-like_AB | Domain | 30,514 | false | false | This entry represents the α+β domain found just before the C-terminal domain of Cullin proteins ( ). This entry also includes Anaphase-promoting complex subunit 2 proteins which are a type of Cullin proteins. Cullins are a family of hydrophobic proteins that act as scaffolds for ubiquitin ligases (E3). Cullins are foun... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26557"
] | [
"Cullin_AB"
] | [
30514
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-CEL-110314",
"R-CEL-1234176",
"R-CEL-187577",
"R-CEL-195253",
"R-CEL-2565942",
"R-CEL-4641258",
"R-CEL-5632684",
"R-CEL-5696394",
"R-CEL-5696395",
"R-CEL-5696400",
"R-CEL-6781823",
"R-CEL-6782135",
"R-CEL-6782210",
"R-CEL-68949",
"R-CEL-69231",
"R-CEL-69601",
"R-CEL-8854050",
"R... | [
"REACTOME:R-CEL-110314",
"REACTOME:R-CEL-1234176",
"REACTOME:R-CEL-187577",
"REACTOME:R-CEL-195253",
"REACTOME:R-CEL-2565942",
"REACTOME:R-CEL-4641258",
"REACTOME:R-CEL-5632684",
"REACTOME:R-CEL-5696394",
"REACTOME:R-CEL-5696395",
"REACTOME:R-CEL-5696400",
"REACTOME:R-CEL-6781823",
"REACTOME:R... | 242 | [
"1ldj",
"1ldk",
"1u6g",
"2hye",
"3dpl",
"3dqv",
"3rtr",
"4a0c",
"4a0k",
"4a0l",
"4f52",
"4p5o",
"4ui9",
"5a31",
"5g04",
"5g05",
"5khr",
"5khu",
"5l9t",
"5l9u",
"5lcw",
"5n4w",
"6q6g",
"6q6h",
"6r6h",
"6r7f",
"6r7h",
"6r7i",
"6r7n",
"6tlj",
"6tm5",
"6tnt"... | 123 | [
"PUB00000937",
"PUB00010627",
"PUB00031678",
"PUB00042618",
"PUB00075111",
"PUB00103546"
] | [
"8681378",
"11961546",
"15537541",
"15688063",
"24793696",
"36041947"
] | [
"cul-1 is required for cell cycle exit in C. elegans and identifies a novel gene family.",
"Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex.",
"Structure of the Cand1-Cul1-Roc1 complex reveals regulatory mechanisms for the assembly of the multisubunit cullin-dependent ubiquitin ligases.",... | [
1996,
2002,
2004,
2005,
2014,
2023
] | 6 | [] | [] | 0 | 0 | null | [
"Acetobacter sacchari",
"Eukaryota",
"Viruses",
"metagenomes"
] | [
1,
30471,
37,
5
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
25,
9,
32,
13,
53,
31,
4,
25,
41,
4,
4,
65
] | 12 | true | Domain | Cullin-like, alpha+beta domain | Cullin-like, alpha+beta domain | Cullin-like_AB | 6 |
IPR059121 | 59,121 | ZFPM2-like, C-terminal CCHC zinc finger | CCHC_ZFPM2-like | Domain | 3,024 | false | false | This domain is found at the C-terminal end of the human zinc finger protein ZFPM2 and related animal proteins, including ZFPM1 and ZNF800. ZFPM2 is a transcriptional regulator that plays a central role in the heart morphogenesis and development of coronary vessels from epicardium, by regulating genes that are essential... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25445"
] | [
"CCHC_ZFPM2"
] | [
3024
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-8936459",
"R-HSA-9690406",
"R-HSA-983231",
"R-MMU-8936459",
"R-MMU-983231"
] | [
"REACTOME:R-HSA-8936459",
"REACTOME:R-HSA-9690406",
"REACTOME:R-HSA-983231",
"REACTOME:R-MMU-8936459",
"REACTOME:R-MMU-983231"
] | 5 | [
"1fu9",
"1jn7"
] | 2 | [
"PUB00160121",
"PUB00160122"
] | [
"10330188",
"12223418"
] | [
"FOG-2, a heart- and brain-enriched cofactor for GATA transcription factors.",
"Gonadal differentiation, sex determination and normal Sry expression in mice require direct interaction between transcription partners GATA4 and FOG2."
] | [
1999,
2002
] | 2 | [] | [] | 0 | 0 | null | [
"Bilateria"
] | [
3024
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
9,
12,
8,
11
] | 4 | true | Domain | ZFPM2-like, C-terminal CCHC zinc finger | ZFPM2-like, C-terminal CCHC zinc finger | CCHC_ZFPM2-like | 8 |
IPR059122 | 59,122 | WDR5-like, beta-propeller domain | Beta-prop_WDR5-like | Domain | 5,038 | false | false | This is the β-propeller domain of WDR5 and its eukaryotic homologues. WDR5 contributes to histone modification; it may position the N-terminal of histone H3 for efficient trimethylation at 'Lys-4'. It is part of the MLL1/MLL complex, being involved in methylation and dimethylation at 'Lys-4' of histone H3 [ , , ]. It a... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25175"
] | [
"Beta-prop_WDR5"
] | [
5038
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-CEL-2565942",
"R-CEL-3214841",
"R-CEL-3214858",
"R-CEL-69601",
"R-CEL-8936459",
"R-CEL-8951664",
"R-CEL-9772755",
"R-CEL-983168",
"R-DDI-3214841",
"R-DDI-3214858",
"R-DDI-8951664",
"R-DDI-9772755",
"R-DME-3214847",
"R-DME-8936459",
"R-DME-8951664",
"R-DME-9772755",
"R-HSA-3214841"... | [
"REACTOME:R-CEL-2565942",
"REACTOME:R-CEL-3214841",
"REACTOME:R-CEL-3214858",
"REACTOME:R-CEL-69601",
"REACTOME:R-CEL-8936459",
"REACTOME:R-CEL-8951664",
"REACTOME:R-CEL-9772755",
"REACTOME:R-CEL-983168",
"REACTOME:R-DDI-3214841",
"REACTOME:R-DDI-3214858",
"REACTOME:R-DDI-8951664",
"REACTOME:R... | 47 | [
"2cnx",
"2co0",
"2g99",
"2g9a",
"2gnq",
"2h13",
"2h14",
"2h68",
"2h6k",
"2h6n",
"2h6q",
"2h9l",
"2h9m",
"2h9n",
"2h9p",
"2o9k",
"2xl2",
"2xl3",
"3eg6",
"3emh",
"3mxx",
"3n0d",
"3n0e",
"3p4f",
"3psl",
"3smr",
"3ur4",
"3uvk",
"3uvl",
"3uvm",
"3uvn",
"3uvo"... | 191 | [
"PUB00040078",
"PUB00060167",
"PUB00087710",
"PUB00160114"
] | [
"16829959",
"20018852",
"19556245",
"23210835"
] | [
"Histone H3 recognition and presentation by the WDR5 module of the MLL1 complex.",
"Subunit composition and substrate specificity of a MOF-containing histone acetyltransferase distinct from the male-specific lethal (MSL) complex.",
"On the mechanism of multiple lysine methylation by the human mixed lineage leuk... | [
2006,
2010,
2009,
2013
] | 4 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Moorena",
"environmental samples"
] | [
5034,
2,
2
] | 3 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Schizosaccharomyces pombe (stra... | [
6,
3,
3,
3,
2,
4,
1,
5,
6,
1,
9
] | 11 | true | Domain | WDR5-like, beta-propeller domain | WDR5-like, beta-propeller domain | Beta-prop_WDR5-like | 3 |
IPR059123 | 59,123 | Streptomycin biosynthesis protein StrF domain | StrF_dom | Domain | 1,252 | false | false | This domain is found standalone in Streptomycin biosynthesis protein StrF and in uncharacterised bacterial proteins predicted to adopt a fold typical for Nucleotide-diphospho-sugar transferases . StrF is encoded by a gene which is part of the strFGHIK gene cluster [ ]. The products of the strF and/or strG genes may be ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF13712"
] | [
"Glyco_tranf_2_5"
] | [
1252
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00003744"
] | [
"1654502"
] | [
"Genetics of streptomycin production in Streptomyces griseus: nucleotide sequence of five genes, strFGHIK, including a phosphatase gene."
] | [
1991
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Methanobacteriota",
"Ricinus communis",
"metagenomes",
"uncultured Caudovirales phage"
] | [
1193,
38,
1,
17,
3
] | 5 | [] | [] | 0 | true | Domain | Streptomycin biosynthesis protein StrF domain | Streptomycin biosynthesis protein StrF domain | StrF_dom | 1 |
IPR059124 | 59,124 | Host cell factor, Kelch-repeats domain | Kelch_HCF | Domain | 3,328 | false | false | This entry represents the Kelch-repeats domain of HCF proteins. Host cell factor 1 (HCF1) and Host cell factor 2 (HCF2) contain an N-terminal kelch domain and a C-terminal FnIII domain . However, HCF2 is smaller than HCF-1, lacking the complete central region including the HCF1 specific repeats and as a result is not s... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF13854"
] | [
"Kelch_HCF"
] | [
3328
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-CEL-9772755",
"R-DME-3214847",
"R-DME-5689603",
"R-DME-9772755",
"R-HSA-2151201",
"R-HSA-3214847",
"R-HSA-5689603",
"R-HSA-9772755",
"R-MMU-3214847",
"R-MMU-5689603",
"R-MMU-9772755",
"R-RNO-3214847",
"R-RNO-5689603",
"R-RNO-9772755"
] | [
"REACTOME:R-CEL-9772755",
"REACTOME:R-DME-3214847",
"REACTOME:R-DME-5689603",
"REACTOME:R-DME-9772755",
"REACTOME:R-HSA-2151201",
"REACTOME:R-HSA-3214847",
"REACTOME:R-HSA-5689603",
"REACTOME:R-HSA-9772755",
"REACTOME:R-MMU-3214847",
"REACTOME:R-MMU-5689603",
"REACTOME:R-MMU-9772755",
"REACTOM... | 14 | [] | 0 | [
"PUB00033478",
"PUB00060167",
"PUB00060556",
"PUB00088156",
"PUB00094183",
"PUB00094184",
"PUB00100195",
"PUB00132368"
] | [
"12670868",
"20018852",
"20200153",
"22174740",
"12609738",
"31049581",
"2568582",
"23629655"
] | [
"Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1.",
"Subunit composition and substrate specificity of a MOF-containing histone acetyltransferase distinct from the male-specific lethal (MSL) complex.",
... | [
2003,
2010,
2010,
2011,
2003,
2019,
1989,
2013
] | 8 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"bird metagenome"
] | [
3326,
2
] | 2 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
7,
1,
7,
5,
11
] | 6 | true | Domain | Host cell factor, Kelch-repeats domain | Host cell factor, Kelch-repeats domain | Kelch_HCF | 9 |
IPR059125 | 59,125 | Ferritin-like domain, actinomycetes | Ferritin_actino | Domain | 3,512 | false | false | This entry represents an uncharacterised domain which is found mainly in actinomycetes. This domain adopts ferritin-like fold elaborated with additional α-hairpin . The function of this domain is unknown. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF13794"
] | [
"Ferritin_fold-like"
] | [
3512
] | 1 | [] | [] | [] | 0 | [
"3ez0"
] | 1 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Opisthokonta",
"metagenomes"
] | [
2,
3451,
2,
57
] | 4 | [] | [] | 0 | true | Domain | Ferritin-like domain, actinomycetes | Ferritin-like domain, actinomycetes | Ferritin_actino | 6 |
IPR059126 | 59,126 | PRDM15, C2H2 zinc finger domain | Znf-C2H2_PRDM15 | Domain | 1,105 | false | false | This C2H2 zinc finger domain is found in the human PR domain zinc finger protein 15 (PRDM15) and related proteins from vertebrates. PRDM15 plays an essential role as a chromatin factor that modulates the transcription of upstream regulators of WNT and MAPK-ERK signaling to safeguard naive pluripotency [ ]. The PRDM fam... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23573"
] | [
"zf-C2H2_PRDM15"
] | [
1105
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00095964",
"PUB00095970",
"PUB00095980"
] | [
"24095733",
"32290321",
"28740264"
] | [
"Molecular basis for the regulation of the H3K4 methyltransferase activity of PRDM9.",
"Multifaceted Role of PRDM Proteins in Human Cancer.",
"PRDM15 safeguards naive pluripotency by transcriptionally regulating WNT and MAPK-ERK signaling."
] | [
2013,
2020,
2017
] | 3 | [] | [] | 0 | 0 | null | [
"Bilateria"
] | [
1105
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
5,
1,
2
] | 4 | true | Domain | PRDM15, C2H2 zinc finger domain | PRDM15, C2H2 zinc finger domain | Znf-C2H2_PRDM15 | 7 |
IPR059127 | 59,127 | Diguanylate cyclase-like sensor domain | Diguanyl_cycl_sensor_dom | Domain | 433 | false | false | This entry represents a sensor domain found at the N-terminal of the putative diguanylate cyclase from Shewanella oneidensis, whose structure was solved ( ). Members of this group are found in bacteria. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24820"
] | [
"Diguanyl_cycl_sensor"
] | [
433
] | 1 | [] | [] | [] | 0 | [
"3mfx"
] | 1 | [] | [] | [] | [] | 0 | [
"IPR000014"
] | [] | 1 | 0 | 1 | [
"Bacteria",
"Eukaryota",
"Methanofollis formosanus",
"ecological metagenomes"
] | [
425,
4,
1,
3
] | 4 | [] | [] | 0 | true | Domain | Diguanylate cyclase-like sensor domain | Diguanylate cyclase-like sensor domain | Diguanyl_cycl_sensor_dom | 4 |
IPR059128 | 59,128 | Maltogenic amylase, second beta-sandwich domain | SMMA_beta-sandwich_2 | Domain | 15 | false | false | This entry represents the second β-sandwich domain (N domain) present in Staphylothermus marinus maltogenic amylase (SMMA, ) and related proteins. SMMA is an extreme thermophile maltogenic amylase with an optimal temperature of 100 C, which hydrolyses alpha(1-4)glycosyl linkages in cyclodextrins and in linear malto-oli... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF22426"
] | [
"SMMA_N"
] | [
15
] | 1 | [] | [] | [] | 0 | [
"4aee"
] | 1 | [
"PUB00065906"
] | [
"22223643"
] | [
"Association of novel domain in active site of archaic hyperthermophilic maltogenic amylase from Staphylothermus marinus."
] | [
2012
] | 1 | [] | [] | 0 | 0 | null | [
"Thermoprotei"
] | [
15
] | 1 | [] | [] | 0 | true | Domain | Maltogenic amylase, second beta-sandwich domain | Maltogenic amylase, second beta-sandwich domain | SMMA_beta-sandwich_2 | 4 |
IPR059129 | 59,129 | Pathogenicity island 2 effector protein SseE, putative | SseE_put | Family | 413 | false | false | This protein family represents a group of putative pathogenicity island 2 effector SseE proteins from Salmonella species. | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF011887"
] | [
"PRK15360.1"
] | [
413
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Pseudomonadati"
] | [
413
] | 1 | [] | [] | 0 | true | Family | Pathogenicity island 2 effector protein SseE, putative | Pathogenicity island 2 effector protein SseE, putative | SseE_put | 3 |
IPR059130 | 59,130 | Morphogenic membrane protein MmpA, putative | MmpA_put | Family | 320 | false | false | This protein family represents a group of uncharacterised proteins from Streptomyces, including the putative morphogenic membrane protein MmpA. | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF046122"
] | [
"morpho_MmpA"
] | [
320
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00159414"
] | [
"30530707"
] | [
"Novel Two-Component System MacRS Is a Pleiotropic Regulator That Controls Multiple Morphogenic Membrane Protein Genes in <i>Streptomyces coelicolor</i>."
] | [
2019
] | 1 | [] | [] | 0 | 0 | null | [
"Actinomycetes"
] | [
320
] | 1 | [] | [] | 0 | true | Family | Morphogenic membrane protein MmpA, putative | Morphogenic membrane protein MmpA, putative | MmpA_put | 8 |
IPR059131 | 59,131 | Intron-associated endonuclease 1, zinc finger domain | I-TevI_Znf | Domain | 46 | false | false | This entry represent the unusual zinc finger domain present in the -ntron-associated endonuclease 1 (I-TevI) [ , ], which comprises the unusual sequence CXCX10CXXC. The Zn finger interacts with the DNA through two hydrogen bonds, between the main chain nitrogen atoms of residues Tyr162 and Ser165 [ ]. I-TevI is a site-... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF22635"
] | [
"I-TevI_ZnF"
] | [
46
] | 1 | [] | [] | [] | 0 | [
"1i3j",
"1t2t"
] | 2 | [
"PUB00017039",
"PUB00031298"
] | [
"11447104",
"15361856"
] | [
"Intertwined structure of the DNA-binding domain of intron endonuclease I-TevI with its substrate.",
"Intron-encoded homing endonuclease I-TevI also functions as a transcriptional autorepressor."
] | [
2001,
2004
] | 2 | [] | [] | 0 | 0 | null | [
"Viruses"
] | [
46
] | 1 | [] | [] | 0 | true | Domain | Intron-associated endonuclease 1, zinc finger domain | Intron-associated endonuclease 1, zinc finger domain | I-TevI_Znf | 6 |
IPR059132 | 59,132 | Quorum sensing histidine kinase QseC | QseC | Family | 1,426 | false | false | This entry represents Sensor protein QseC from Escherichia coli and similar proteins from gammaproteobacteria. QseC is a member of a two-component regulatory system QseB/QseC. It activates the flagella regulon by activating transcription of FlhDC [ ]. | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF007664"
] | [
"PRK10337.1"
] | [
1426
] | 1 | [
"EC"
] | [
"2.7.13.3"
] | [
"EC:2.7.13.3"
] | 1 | [] | 0 | [
"PUB00075428",
"PUB00104596",
"PUB00104597",
"PUB00104598"
] | [
"11929534",
"26426681",
"28396353",
"35464966"
] | [
"Quorum sensing Escherichia coli regulators B and C (QseBC): a novel two-component regulatory system involved in the regulation of flagella and motility by quorum sensing in E. coli.",
"QseBC, a two-component bacterial adrenergic receptor and global regulator of virulence in Enterobacteriaceae and Pasteurellaceae... | [
2002,
2016,
2017,
2022
] | 4 | [
"IPR050428"
] | [] | 1 | 0 | 1 | [
"Bacteria",
"Beauveria bassiana D1-5",
"human gut metagenome"
] | [
1424,
1,
1
] | 3 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Quorum sensing histidine kinase QseC | Quorum sensing histidine kinase QseC | QseC | 7 |
IPR059133 | 59,133 | TsoY-like | TsoY-like | Family | 372 | false | false | This family of uncharacterised bacterial proteins includes the predicted TsoY and similar selenoproteins. Some members are not selenoproteins but have Cys at a position equivalent to the Sec (U) in TsoY selenoproteins. The function is unknown. | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF047644"
] | [
"TsoY_fam"
] | [
372
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Methanolobus tindarius DSM 2278",
"bioreactor metagenome"
] | [
370,
1,
1
] | 3 | [] | [] | 0 | true | Family | TsoY-like | TsoY-like | TsoY-like | 8 |
IPR059134 | 59,134 | BsNagA, composite domain | BsNagA_N | Domain | 68 | false | false | This entry represents the composite domain of NagA from Bacillus subtilis [ ], a N-acetylglucosamine-6-phosphate deacetylase and other bacilli, similar to that from E.coli. However, they have some sequence differences [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF22644"
] | [
"BsNagA_N"
] | [
68
] | 1 | [] | [] | [] | 0 | [
"2vhl"
] | 1 | [
"PUB00014260"
] | [
"14557261"
] | [
"The three-dimensional structure of the N-acetylglucosamine-6-phosphate deacetylase, NagA, from Bacillus subtilis: a member of the urease superfamily."
] | [
2004
] | 1 | [] | [] | 0 | 0 | null | [
"Bacillota",
"Clonostachys byssicola"
] | [
67,
1
] | 2 | [] | [] | 0 | true | Domain | BsNagA, composite domain | BsNagA, composite domain | BsNagA_N | 2 |
IPR059135 | 59,135 | APOBEC2, cytosine deaminase domain | APOBEC2_CD_dom | Domain | 923 | false | false | This entry represents a domain found standalone in APOBEC2 and homologous to known CMP/dCMP-type deaminase domains [ ]. APOBEC2 is a highly conserved (slow-evolving) family of AID/APOBEC-like deaminases found in most vertebrates including cartilaginous fishes. APOBEC2 is poorly understood in terms of their molecular fu... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF18772"
] | [
"APOBEC2"
] | [
923
] | 1 | [
"EC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"3.5.4.36",
"R-HSA-72200",
"R-HSA-75094",
"R-MMU-72200",
"R-MMU-75094"
] | [
"EC:3.5.4.36",
"REACTOME:R-HSA-72200",
"REACTOME:R-HSA-75094",
"REACTOME:R-MMU-72200",
"REACTOME:R-MMU-75094"
] | 5 | [
"2nyt",
"2rpz"
] | 2 | [
"PUB00042074",
"PUB00088593",
"PUB00091285",
"PUB00161713",
"PUB00161717"
] | [
"17187054",
"26608778",
"29555751",
"38625936",
"27283515"
] | [
"The APOBEC-2 crystal structure and functional implications for the deaminase AID.",
"DNA Editing by APOBECs: A Genomic Preserver and Transformer.",
"Diversification of AID/APOBEC-like deaminases in metazoa: multiplicity of clades and widespread roles in immunity.",
"APOBEC2 safeguards skeletal muscle cell fa... | [
2007,
2016,
2018,
2024,
2016
] | 5 | [
"IPR002125"
] | [] | 1 | 0 | 1 | [
"Gnathostomata"
] | [
923
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
1,
1,
2
] | 4 | true | Domain | APOBEC2, cytosine deaminase domain | APOBEC2, cytosine deaminase domain | APOBEC2_CD_dom | 7 |
IPR059136 | 59,136 | APOBEC3, cytosine deaminase domain | APOBEC3_CD_dom | Domain | 1,373 | false | false | This domain is found in APOBEC3 (A/B/C/D/F/G) proteins and is homologous to known CMP/dCMP-type deaminase domains. APOBEC3 proteins are a family of cytidine deaminases that play a crucial role in the host's intrinsic immunity by restricting the replication of viruses - particularly retroviruses like HIV-1 - and inhibit... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF18782"
] | [
"APOBEC3"
] | [
1373
] | 1 | [
"EC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"3.5.4.38",
"R-HSA-180585",
"R-HSA-180689",
"R-HSA-72200",
"R-HSA-75094",
"R-MMU-72200",
"R-MMU-75094",
"R-RNO-72200",
"R-RNO-75094"
] | [
"EC:3.5.4.38",
"REACTOME:R-HSA-180585",
"REACTOME:R-HSA-180689",
"REACTOME:R-HSA-72200",
"REACTOME:R-HSA-75094",
"REACTOME:R-MMU-72200",
"REACTOME:R-MMU-75094",
"REACTOME:R-RNO-72200",
"REACTOME:R-RNO-75094"
] | 9 | [
"2jyw",
"2kbo",
"2kem",
"2m65",
"2mzz",
"2nbq",
"3e1u",
"3iqs",
"3ir2",
"3v4j",
"3v4k",
"3vm8",
"3vow",
"3wus",
"4iou",
"4j4j",
"4rov",
"4row",
"4xxo",
"5cqd",
"5cqh",
"5cqi",
"5cqk",
"5hx4",
"5hx5",
"5k81",
"5k82",
"5k83",
"5keg",
"5sww",
"5sxg",
"5sxh"... | 75 | [
"PUB00088593",
"PUB00091285",
"PUB00161714",
"PUB00161715",
"PUB00161716",
"PUB00161717"
] | [
"26608778",
"29555751",
"25590131",
"25914058",
"22157092",
"27283515"
] | [
"DNA Editing by APOBECs: A Genomic Preserver and Transformer.",
"Diversification of AID/APOBEC-like deaminases in metazoa: multiplicity of clades and widespread roles in immunity.",
"Promiscuous RNA binding ensures effective encapsidation of APOBEC3 proteins by HIV-1.",
"The ssDNA Mutator APOBEC3A Is Regulate... | [
2016,
2018,
2015,
2015,
2012,
2016
] | 6 | [
"IPR002125"
] | [] | 1 | 0 | 1 | [
"Bacteroidota",
"Metazoa"
] | [
2,
1371
] | 2 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
28,
22,
7
] | 3 | true | Domain | APOBEC3, cytosine deaminase domain | APOBEC3, cytosine deaminase domain | APOBEC3_CD_dom | 9 |
IPR059138 | 59,138 | Picornavirus capsid VP1 | Pico_VP1 | Domain | 45,216 | false | false | This entry represents the VP1 domain found in capsid proteins from picornavirus. The Picornaviridae family includes rhinovirus (common cold), poliovirus, hepatitis A virus, foot-and-mouth disease virus and encephalomyocarditis virus [ , , , , ]. The capsid coat protein composition of picornaviruses consists of multiple... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF22663"
] | [
"Rhv_5"
] | [
45216
] | 1 | [
"EC",
"EC"
] | [
"2.7.7.48",
"3.4.22.28"
] | [
"EC:2.7.7.48",
"EC:3.4.22.28"
] | 2 | [
"1aym",
"1ayn",
"1bev",
"1c8m",
"1cov",
"1d3e",
"1jew",
"1m11",
"1mec",
"1ncr",
"1nd2",
"1nd3",
"1qju",
"1qjx",
"1qjy",
"1tme",
"1tmf",
"2mev",
"2wff",
"2ws9",
"2wzr",
"2x5i",
"2xbo",
"3cji",
"3iyp",
"3j22",
"3j23",
"3j91",
"3jd7",
"3vbf",
"3vbh",
"3vbo"... | 270 | [
"PUB00006370",
"PUB00021157",
"PUB00023594",
"PUB00036395",
"PUB00043177",
"PUB00080087",
"PUB00080088",
"PUB00161718"
] | [
"9083115",
"9253417",
"7773791",
"8382928",
"15299757",
"10729171",
"10753813",
"25184560"
] | [
"The refined structure of human rhinovirus 16 at 2.15 A resolution: implications for the viral life cycle.",
"Structural studies of poliovirus mutants that overcome receptor defects.",
"Implications for viral uncoating from the structure of bovine enterovirus.",
"Methods used in the structure determination of... | [
1997,
1997,
1995,
1993,
1995,
2000,
2000,
2014
] | 8 | [] | [] | 0 | 0 | null | [
"Riboviria",
"Trichinella"
] | [
45212,
4
] | 2 | [] | [] | 0 | true | Domain | Picornavirus capsid VP1 | Picornavirus capsid VP1 | Pico_VP1 | 1 |
IPR059141 | 59,141 | Nucleoporin Nup120/160, beta-propeller domain | Beta-prop_Nup120_160 | Domain | 4,570 | false | false | This entry represents the β-propeller at the N-terminal in Nup120 and Nup160 proteins from eukaryotes. Nup120 is conserved from fungi to plants to humans, and is homologous with the Nup160 of vertebrates. The nuclear core complex, or NPC, mediates macromolecular transport across the nuclear envelope. Deletion of the NU... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF11715"
] | [
"Beta-prop_Nup120_160"
] | [
4570
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-DME-159227",
"R-DME-159230",
"R-DME-159231",
"R-DME-159236",
"R-DME-170822",
"R-DME-3108214",
"R-DME-3301854",
"R-DME-4085377",
"R-DME-4551638",
"R-DME-4615885",
"R-DME-5578749",
"R-DME-9615933",
"R-HSA-1169408",
"R-HSA-141444",
"R-HSA-159227",
"R-HSA-159230",
"R-HSA-159231",
"R... | [
"REACTOME:R-DME-159227",
"REACTOME:R-DME-159230",
"REACTOME:R-DME-159231",
"REACTOME:R-DME-159236",
"REACTOME:R-DME-170822",
"REACTOME:R-DME-3108214",
"REACTOME:R-DME-3301854",
"REACTOME:R-DME-4085377",
"REACTOME:R-DME-4551638",
"REACTOME:R-DME-4615885",
"REACTOME:R-DME-5578749",
"REACTOME:R-D... | 85 | [
"3f7f",
"3h7n",
"3hxr",
"4fhm",
"4fhn",
"4gq2",
"4xmm",
"4xmn",
"5a9q",
"6lk8",
"6x06",
"7fik",
"7n84",
"7n9f",
"7peq",
"7r5j",
"7r5k",
"7tbi",
"7tbj",
"7tbk",
"7tbl",
"7tbm",
"7tdz",
"7vci",
"7vop",
"7wb4",
"8tie",
"9hcj",
"9sob"
] | 29 | [
"PUB00019951",
"PUB00053539",
"PUB00152296"
] | [
"11684705",
"8557736",
"17360435"
] | [
"Novel vertebrate nucleoporins Nup133 and Nup160 play a role in mRNA export.",
"Nup120p: a yeast nucleoporin required for NPC distribution and mRNA transport.",
"Cell-cycle-dependent phosphorylation of the nuclear pore Nup107-160 subcomplex."
] | [
2001,
1995,
2007
] | 3 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
4570
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
10,
2,
2,
2,
5,
1,
1,
1,
3,
1,
1,
32
] | 12 | true | Domain | Nucleoporin Nup120/160, beta-propeller domain | Nucleoporin Nup120/160, beta-propeller domain | Beta-prop_Nup120_160 | 9 |
IPR059142 | 59,142 | Uncharacterized protein YGL204C | YGL204C | Family | 3 | false | false | This protein family includes the uncharacterised protein YGL204C from Saccharomyces cerevisiae, a micropeptide encoded by a small open reading frame (smORF) [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23480"
] | [
"YGL204C"
] | [
3
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00155509"
] | [
"29897761"
] | [
"Enrichment-Based Proteogenomics Identifies Microproteins, Missing Proteins, and Novel smORFs in Saccharomyces cerevisiae."
] | [
2018
] | 1 | [] | [] | 0 | 0 | null | [
"Saccharomycetaceae"
] | [
3
] | 1 | [
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)"
] | [
1
] | 1 | true | Family | Uncharacterized protein YGL204C | Uncharacterized protein YGL204C | YGL204C | 8 |
IPR059143 | 59,143 | NFP, second LysM domain | NFP_LysM2 | Domain | 1,322 | false | false | This entry represents the second LysM domain (LysM2) found in NFP from Medicago truncatula and similar plant proteins. The LysM domain adopt a β-α-α-β fold, according to structure predictions and the crystal structure [ ]. The NFP LysM2 domain, and L154 in particular, are crucial for the entry step of rhizobia, suggest... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23457"
] | [
"LysM2_NFP"
] | [
1322
] | 1 | [] | [] | [] | 0 | [
"7au7",
"7bax"
] | 2 | [
"PUB00001727",
"PUB00019876",
"PUB00082420",
"PUB00155726",
"PUB00155730"
] | [
"1352512",
"10369758",
"15120137",
"34716271",
"22087221"
] | [
"Modular design of the Enterococcus hirae muramidase-2 and Streptococcus faecalis autolysin.",
"Eukaryotic signalling domain homologues in archaea and bacteria. Ancient ancestry and horizontal gene transfer.",
"Specific recognition of bacteria by plant LysM domain receptor kinases.",
"Kinetic proofreading of ... | [
1992,
1999,
2004,
2021,
2011
] | 5 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Embryophyta"
] | [
3,
1319
] | 2 | [
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
7,
39
] | 2 | true | Domain | NFP, second LysM domain | NFP, second LysM domain | NFP_LysM2 | 9 |
IPR059144 | 59,144 | NFP, third LysM domain | NFP_LysM3 | Domain | 887 | false | false | This entry represents the third LysM domain (LysM3) found in NFP from Medicago truncatula and related plant proteins. LysM3 also plays a role in infection, although a less important role than that of LysM2 [ ]. NFP/NFR5 class of receptors are crucial for initial lipochitooligosaccharide (LCO) perception and essential f... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23462"
] | [
"LysM3_NFP"
] | [
887
] | 1 | [] | [] | [] | 0 | [
"7au7",
"7bax"
] | 2 | [
"PUB00001727",
"PUB00019876",
"PUB00082420",
"PUB00155726",
"PUB00155730"
] | [
"1352512",
"10369758",
"15120137",
"34716271",
"22087221"
] | [
"Modular design of the Enterococcus hirae muramidase-2 and Streptococcus faecalis autolysin.",
"Eukaryotic signalling domain homologues in archaea and bacteria. Ancient ancestry and horizontal gene transfer.",
"Specific recognition of bacteria by plant LysM domain receptor kinases.",
"Kinetic proofreading of ... | [
1992,
1999,
2004,
2021,
2011
] | 5 | [] | [] | 0 | 0 | null | [
"Magnoliopsida"
] | [
887
] | 1 | [
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
2,
4
] | 2 | true | Domain | NFP, third LysM domain | NFP, third LysM domain | NFP_LysM3 | 4 |
IPR059145 | 59,145 | Maltogenic amylase, GHD-like C-terminal domain | SMMA_C | Domain | 3 | false | false | This entry represents the C-terminal GHD-like domain present in Staphylothermus marinus maltogenic amylase (SMMA, ) and related proteins. SMMA is an extreme thermophile maltogenic amylase with an optimal temperature of 100 C, which hydrolyses alpha(1-4)glycosyl linkages in cyclodextrins and in linear malto-oligosacchar... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF22427"
] | [
"SMMA_C"
] | [
3
] | 1 | [] | [] | [] | 0 | [
"4aee"
] | 1 | [
"PUB00065906"
] | [
"22223643"
] | [
"Association of novel domain in active site of archaic hyperthermophilic maltogenic amylase from Staphylothermus marinus."
] | [
2012
] | 1 | [] | [] | 0 | 0 | null | [
"Staphylothermus"
] | [
3
] | 1 | [] | [] | 0 | true | Domain | Maltogenic amylase, GHD-like C-terminal domain | Maltogenic amylase, GHD-like C-terminal domain | SMMA_C | 6 |
IPR059146 | 59,146 | Ctf19, first RWD domain | Ctf19_RWD1 | Domain | 4 | false | false | This entry represents the first occurrence of the RWD domain within the Ctf19 subunit of the inner kinetochore in Kluyveromyces lactis. Ctf19 is a component of the constitutive centromere-associated network (CCAN), which forms the structural basis of the kinetochore. The CCAN governs the timing of kinetochore assembly,... | [] | [] | [] | 0 | [
"PFAM",
"CDD"
] | [
"PF22463",
"cd23789"
] | [
"Ctf19_RWD1",
"DRWD-N_KlCTF19"
] | [
4,
3
] | 2 | [] | [] | [] | 0 | [
"3zxu",
"5mu3"
] | 2 | [
"PUB00058475",
"PUB00153895"
] | [
"22322944",
"29046335"
] | [
"RWD domain: a recurring module in kinetochore architecture shown by a Ctf19-Mcm21 complex structure.",
"Molecular basis for inner kinetochore configuration through RWD domain-peptide interactions."
] | [
2012,
2017
] | 2 | [] | [] | 0 | 0 | null | [
"Kluyveromyces"
] | [
4
] | 1 | [] | [] | 0 | true | Domain | Ctf19, first RWD domain | Ctf19, first RWD domain | Ctf19_RWD1 | 4 |
IPR059147 | 59,147 | Ctf19, second RWD domain | Ctf19_RWD2 | Domain | 4 | false | false | This entry represents the second occurrence of the RWD domain within the Ctf19 subunit of the inner kinetochore in Kluyveromyces lactis. Ctf19 is a component of the constitutive centromere-associated network (CCAN), which forms the structural basis of the kinetochore. The CCAN governs the timing of kinetochore assembly... | [] | [] | [] | 0 | [
"PFAM",
"CDD"
] | [
"PF22462",
"cd23788"
] | [
"Ctf19_RWD2",
"DRWD-C_KlCTF19"
] | [
4,
4
] | 2 | [] | [] | [] | 0 | [
"3zxu",
"5mu3"
] | 2 | [
"PUB00058475",
"PUB00153895"
] | [
"22322944",
"29046335"
] | [
"RWD domain: a recurring module in kinetochore architecture shown by a Ctf19-Mcm21 complex structure.",
"Molecular basis for inner kinetochore configuration through RWD domain-peptide interactions."
] | [
2012,
2017
] | 2 | [] | [] | 0 | 0 | null | [
"Kluyveromyces"
] | [
4
] | 1 | [] | [] | 0 | true | Domain | Ctf19, second RWD domain | Ctf19, second RWD domain | Ctf19_RWD2 | 7 |
IPR059148 | 59,148 | Crb2, C-terminal domain | Crb2_C | Domain | 3 | false | false | This entry represents the C-terminal domain which contains a BRCT-like fold present in Crb2 from Schizosaccharomyces pombe. Crb2 relies on the BRCT-like domain for its dimerisation [ ]. Crb2 is a checkpoint mediator required for the cellular response to DNA damage [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF22395"
] | [
"Crb2-like_BRCT-like"
] | [
3
] | 1 | [
"REACTOME",
"REACTOME"
] | [
"R-SPO-3232118",
"R-SPO-5693565"
] | [
"REACTOME:R-SPO-3232118",
"REACTOME:R-SPO-5693565"
] | 2 | [
"2vxb",
"2vxc"
] | 2 | [
"PUB00049944",
"PUB00102334"
] | [
"18676809",
"22792081"
] | [
"Structural and functional analysis of the Crb2-BRCT2 domain reveals distinct roles in checkpoint signaling and DNA damage repair.",
"Phosphorylation-dependent interactions between Crb2 and Chk1 are essential for DNA damage checkpoint."
] | [
2008,
2012
] | 2 | [] | [] | 0 | 0 | null | [
"Schizosaccharomyces"
] | [
3
] | 1 | [
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
1
] | 1 | true | Domain | Crb2, C-terminal domain | Crb2, C-terminal domain | Crb2_C | 4 |
IPR059149 | 59,149 | Protein EFFECTOR OF TRANSCRIPTION 2/3, GIY-YIG domain | GIY_YIG_dom_ET2/3 | Domain | 811 | false | false | This entry represents the GIY-YIG domain found in Protein EFFECTOR OF TRANSCRIPTION 2 and 3 from Arabidopsis thaliana and related proteins. This is a well characterised domain among the members of the GYI-YIG endonuclease family, which is involved in several cellular processes such as DNA repair and recombination and t... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF19239"
] | [
"GIY_YIG_domain"
] | [
811
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00017038",
"PUB00088544",
"PUB00088545",
"PUB00088546"
] | [
"12379841",
"17991462",
"16244914",
"22226340"
] | [
"Catalytic domain structure and hypothesis for function of GIY-YIG intron endonuclease I-TevI.",
"EFFECTOR OF TRANSCRIPTION2 is involved in xylem differentiation and includes a functional DNA single strand cutting domain.",
"Ectopic expression of EFFECTOR OF TRANSCRIPTION perturbs gibberellin-mediated plant dev... | [
2002,
2008,
2005,
2012
] | 4 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Chlorovirus",
"Eukaryota",
"marine sediment metagenome"
] | [
5,
8,
797,
1
] | 4 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
12,
2,
6
] | 3 | true | Domain | Protein EFFECTOR OF TRANSCRIPTION 2/3, GIY-YIG domain | Protein EFFECTOR OF TRANSCRIPTION 2/3, GIY-YIG domain | GIY_YIG_dom_ET2/3 | 2 |
IPR059150 | 59,150 | Pichia pastoris 6-phosphofructokinase, gamma subunit, C-terminal | PpPfk_gamma_C | Domain | 5 | false | false | This domain is found at the C-terminal in PFK3 subunit gamma. Pichia pastoris 6-phosphofructokinase (PpPfk or PFK3) is the most complex and probably largest (1 MDa) eukaryotic Pfk [ ]. It forms a dodecamer of four α-β-γ trimers [ ]. The gamma subunit is unique, in contrast to other eukaryotic ATP-dependent 6-phosphofru... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF22457"
] | [
"PpPFK_gamma-like_C"
] | [
5
] | 1 | [] | [] | [] | 0 | [
"3opy"
] | 1 | [
"PUB00081272",
"PUB00081273",
"PUB00081274",
"PUB00081275"
] | [
"19559794",
"17522059",
"12125050",
"20833871"
] | [
"3D structure of phosphofructokinase from Pichia pastoris: Localization of the novel gamma-subunits.",
"A novel form of 6-phosphofructokinase. Identification and functional relevance of a third type of subunit in Pichia pastoris.",
"6-phosphofructokinase from Pichia pastoris: purification, kinetic and molecular... | [
2009,
2007,
2002,
2011
] | 4 | [] | [] | 0 | 0 | null | [
"Komagataella"
] | [
5
] | 1 | [] | [] | 0 | true | Domain | Pichia pastoris 6-phosphofructokinase, gamma subunit, C-terminal | Pichia pastoris 6-phosphofructokinase, gamma subunit, C-terminal | PpPfk_gamma_C | 8 |
IPR059151 | 59,151 | RavZ, N-terminal domain | RavZ_N | Domain | 10 | false | false | This entry represents the N-terminal in RavZ proteins. The intracellular pathogen Legionella pneumophila interferes with autophagy by delivering an effector protein, cysteine protease RavZ, into the host cytosol. This effector protein cleaves membrane-conjugated Atg8/LC3 proteins from pre-autophagosomal structures [ , ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF24600"
] | [
"RavZ_cat"
] | [
10
] | 1 | [] | [] | [] | 0 | [
"5cqc",
"5hzy",
"5io3",
"5izv",
"5ms2",
"5ms7",
"5ms8"
] | 7 | [
"PUB00154191",
"PUB00154192",
"PUB00154193",
"PUB00154418"
] | [
"26343456",
"27791457",
"28395732",
"32686895"
] | [
"The Legionella Anti-autophagy Effector RavZ Targets the Autophagosome via PI3P- and Curvature-Sensing Motifs.",
"The 1:2 complex between RavZ and LC3 reveals a mechanism for deconjugation of LC3 on the phagophore membrane.",
"Elucidation of the anti-autophagy mechanism of the <i>Legionella</i> effector RavZ us... | [
2015,
2017,
2017,
2020
] | 4 | [] | [] | 0 | 0 | null | [
"Legionella"
] | [
10
] | 1 | [] | [] | 0 | true | Domain | RavZ, N-terminal domain | RavZ, N-terminal domain | RavZ_N | 3 |
IPR059153 | 59,153 | Histone-lysine N-methyltransferase NSD-like, PHD zinc finger 1 | NSD_PHD-1st | Domain | 7,333 | false | false | This domain is found in the NSD (nuclear receptor SET domain-containing) family of histone-lysine N-methyltransferases such as NSD1, NSD2, NSD3 and other related proteins.This domain adopts a classical PHD finger fold and acts as a chromatin reader module. Nuclear receptor-binding SET domain-containing protein 1 (NSD1)... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23011"
] | [
"PHD-1st_NSD"
] | [
7333
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-3214841",
"R-HSA-5693565",
"R-HSA-5693571",
"R-HSA-5693607",
"R-HSA-69473",
"R-MMU-3214841",
"R-MMU-5693565",
"R-MMU-5693571",
"R-MMU-5693607",
"R-MMU-69473"
] | [
"REACTOME:R-HSA-3214841",
"REACTOME:R-HSA-5693565",
"REACTOME:R-HSA-5693571",
"REACTOME:R-HSA-5693607",
"REACTOME:R-HSA-69473",
"REACTOME:R-MMU-3214841",
"REACTOME:R-MMU-5693565",
"REACTOME:R-MMU-5693571",
"REACTOME:R-MMU-5693607",
"REACTOME:R-MMU-69473"
] | 10 | [
"1wen",
"1x4i",
"2k1j",
"2m1r",
"2pnx",
"2vnf",
"4gnd",
"4gne",
"4gnf",
"4gng",
"7cro",
"7crp",
"7crq",
"7crr",
"7zmx",
"9gbf",
"9m4r"
] | 17 | [
"PUB00002003",
"PUB00055387",
"PUB00075727",
"PUB00091523",
"PUB00101938",
"PUB00103118",
"PUB00103120",
"PUB00103121",
"PUB00103122",
"PUB00103123",
"PUB00103124",
"PUB00103125",
"PUB00103126",
"PUB00103127",
"PUB00103128",
"PUB00103129",
"PUB00103130",
"PUB00103131",
"PUB001031... | [
"9618163",
"21196496",
"21555454",
"23269674",
"11896389",
"11733144",
"14997421",
"15382262",
"11493482",
"12433679",
"11337357",
"11152655",
"22645312",
"15677557",
"19481544",
"9787135",
"16115125",
"15257719",
"18172012",
"22099308",
"23980095",
"11986249",
"19380029"... | [
"WHSC1, a 90 kb SET domain-containing gene, expressed in early development and homologous to a Drosophila dysmorphy gene maps in the Wolf-Hirschhorn syndrome critical region and is fused to IgH in t(4;14) multiple myeloma.",
"The Structure of NSD1 Reveals an Autoregulatory Mechanism Underlying Histone H3K36 Methy... | [
1998,
2011,
2011,
2013,
2002,
2001,
2004,
2004,
2001,
2003,
2001,
2001,
2012,
2005,
2009,
1998,
2005,
2004,
2008,
2011,
2013,
2002,
2009,
2011,
2001,
2001,
2006
] | 27 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
7333
] | 1 | [
"Arabidopsis thaliana",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
22,
33,
11,
8,
5,
11,
9
] | 7 | true | Domain | Histone-lysine N-methyltransferase NSD-like, PHD zinc finger 1 | Histone-lysine N-methyltransferase NSD-like, PHD zinc finger 1 | NSD_PHD-1st | 2 |
IPR059154 | 59,154 | D-glucuronyl C5-epimerase, beta-sandwich domain | Glce_b_sandwich | Domain | 1,601 | false | false | This domain is found centrally in D-glucuronyl C5-epimerase from humans (Glce) and similar proteins involved in glycan metabolism and heparin biosynthesis in animals. Glce is essential for the reversible epimerisation of D-glucuronic acid (GlcA) into L-iduronic acid (IdoA), contributing to generate functional protein-b... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF21174"
] | [
"Glce_b_sandwich"
] | [
1601
] | 1 | [
"EC",
"METACYC",
"REACTOME"
] | [
"5.1.3.17",
"PWY-6558",
"R-HSA-2022928"
] | [
"EC:5.1.3.17",
"METACYC:PWY-6558",
"REACTOME:R-HSA-2022928"
] | 3 | [
"4pw2",
"4pxq",
"6hzz",
"6i01",
"6i02"
] | 5 | [
"PUB00088176",
"PUB00151716"
] | [
"25568314",
"30872481"
] | [
"Structural and functional study of D-glucuronyl C5-epimerase.",
"Substrate binding mode and catalytic mechanism of human heparan sulfate d-glucuronyl C5 epimerase."
] | [
2015,
2019
] | 2 | [] | [] | 0 | 0 | null | [
"Eumetazoa",
"Pseudomonadati",
"hydrothermal vent metagenome"
] | [
1594,
5,
2
] | 3 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
5,
2,
3,
2,
2
] | 6 | true | Domain | D-glucuronyl C5-epimerase, beta-sandwich domain | D-glucuronyl C5-epimerase, beta-sandwich domain | Glce_b_sandwich | 7 |
IPR059155 | 59,155 | Glyoxalase domain-containing protein 4 domain | GLOD4_dom | Domain | 1,831 | false | false | This domain is found in Glyoxalase domain- containing protein 4 from humans (GLOD4) and similar proteins from vertebrates and some species of arthropods. This protein seem to be involved in metabolic detoxification [ ]. The specific function of this domain is still unknown. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF21207"
] | [
"GLOD4_N"
] | [
1831
] | 1 | [] | [] | [] | 0 | [
"3zi1",
"9csj"
] | 2 | [
"PUB00151725"
] | [
"24913063"
] | [
"Methionine-induced hyperhomocysteinemia and bleomycin hydrolase deficiency alter the expression of mouse kidney proteins involved in renal disease."
] | [
2014
] | 1 | [] | [] | 0 | 0 | null | [
"Eumetazoa"
] | [
1831
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
7,
4,
3
] | 4 | true | Domain | Glyoxalase domain-containing protein 4 domain | Glyoxalase domain-containing protein 4 domain | GLOD4_dom | 7 |
IPR059156 | 59,156 | WDR36/Utp21, second beta-propeller domain | Beta-prop_WDR36-Utp21_2nd | Domain | 4,921 | false | false | This entry represents the second β-propeller domain, found in the middle region of WDR36 and Utp21. Utp21 from yeast and WDR36 its orthologue in animals are part of the small subunit (SSU) processome, the first precursor of the small eukaryotic ribosomal subunit. They are involved in the nucleolar processing of SSU 18S... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25168"
] | [
"Beta-prop_WDR36-Utp21_2nd"
] | [
4921
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-6790901",
"R-HSA-6791226",
"R-SCE-6791226",
"R-SPO-6791226"
] | [
"REACTOME:R-HSA-6790901",
"REACTOME:R-HSA-6791226",
"REACTOME:R-SCE-6791226",
"REACTOME:R-SPO-6791226"
] | 4 | [
"4nsx",
"5jpq",
"5oql",
"5tzs",
"5wlc",
"5wyj",
"5wyk",
"6ke6",
"6lqp",
"6lqq",
"6lqr",
"6lqs",
"6lqt",
"6lqu",
"6lqv",
"6nd4",
"6rxt",
"6rxu",
"6rxv",
"6rxx",
"6rxy",
"6rxz",
"6zqa",
"6zqb",
"6zqc",
"6zqd",
"6zqe",
"6zqf",
"7ajt",
"7aju",
"7d4i",
"7d5s"... | 51 | [
"PUB00090524",
"PUB00151110"
] | [
"21051332",
"34516797"
] | [
"Lack of WDR36 leads to preimplantation embryonic lethality in mice and delays the formation of small subunit ribosomal RNA in human cells in vitro.",
"Nucleolar maturation of the human small subunit processome."
] | [
2011,
2021
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota"
] | [
61,
4860
] | 2 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
7,
1,
1,
2,
1,
6,
1,
3,
7,
1,
1,
16
] | 12 | true | Domain | WDR36/Utp21, second beta-propeller domain | WDR36/Utp21, second beta-propeller domain | Beta-prop_WDR36-Utp21_2nd | 8 |
IPR059157 | 59,157 | WDR36/Utp21, N-terminal domain | WDR36-Utp21_N | Domain | 4,699 | false | false | This entry represents the first β-propeller domain, found at the N-terminal in WDR36 and Utp21. Utp21 from yeast and WDR36 its orthologue in animals are part of the small subunit (SSU) processome, the first precursor of the small eukaryotic ribosomal subunit. They are involved in the nucleolar processing of SSU 18S rRN... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF25171"
] | [
"Beta-prop_WDR36-Utp21_1st"
] | [
4699
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-6790901",
"R-HSA-6791226",
"R-SCE-6791226",
"R-SPO-6791226"
] | [
"REACTOME:R-HSA-6790901",
"REACTOME:R-HSA-6791226",
"REACTOME:R-SCE-6791226",
"REACTOME:R-SPO-6791226"
] | 4 | [
"4nsx",
"5jpq",
"5oql",
"5tzs",
"5wlc",
"5wyj",
"5wyk",
"6ke6",
"6lqp",
"6lqq",
"6lqr",
"6lqs",
"6lqt",
"6lqu",
"6lqv",
"6nd4",
"6rxt",
"6rxu",
"6rxv",
"6rxx",
"6rxy",
"6rxz",
"6zqa",
"6zqb",
"6zqc",
"6zqd",
"6zqe",
"6zqf",
"7ajt",
"7aju",
"7d4i",
"7d5s"... | 51 | [
"PUB00090524",
"PUB00151110"
] | [
"21051332",
"34516797"
] | [
"Lack of WDR36 leads to preimplantation embryonic lethality in mice and delays the formation of small subunit ribosomal RNA in human cells in vitro.",
"Nucleolar maturation of the human small subunit processome."
] | [
2011,
2021
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota"
] | [
25,
4674
] | 2 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
7,
1,
1,
2,
1,
5,
1,
4,
7,
1,
1,
13
] | 12 | true | Domain | WDR36/Utp21, N-terminal domain | WDR36/Utp21, N-terminal domain | WDR36-Utp21_N | 6 |
IPR059158 | 59,158 | NusA, second KH domain, bacteria | KH_NusA_2nd_bact | Domain | 24,541 | false | false | This entry corresponds to the second KH domain of NusA and similar proteins found predominantly in bacteria. KH domains bind RNA and can function in RNA recognition [ ]. NusA binds to RNA polymerase alpha subunit and promotes termination at certain RNA hairpin structures [ ]. In prokaryotes, the N-terminal RNA polymera... | [] | [] | [] | 0 | [
"CDD"
] | [
"cd22529"
] | [
"KH-II_NusA_rpt2"
] | [
24541
] | 1 | [] | [] | [] | 0 | [
"1hh2",
"1k0r",
"1l2f",
"2asb",
"2atw",
"4mtn",
"5lm7",
"5lm9",
"5ms0",
"6flq",
"6gov",
"6j9e",
"6tqn",
"6tqo",
"6x6t",
"6x7f",
"6x7k",
"6x9q",
"6xas",
"6xav",
"6xdq",
"6z9p",
"6z9q",
"6z9r",
"6z9s",
"6z9t",
"7adb",
"7adc",
"7add",
"7ade",
"7py3",
"7py5"... | 63 | [
"PUB00011739",
"PUB00013514",
"PUB00026604",
"PUB00026894",
"PUB00031711",
"PUB00035579",
"PUB00035974",
"PUB00039388",
"PUB00068867",
"PUB00068870",
"PUB00074114",
"PUB00074116",
"PUB00109732",
"PUB00109733",
"PUB00109734",
"PUB00109735",
"PUB00109736",
"PUB00109737",
"PUB001097... | [
"11430821",
"11040219",
"11743725",
"14621988",
"15365170",
"17437720",
"15987884",
"16193062",
"6263495",
"20696893",
"9139668",
"20600118",
"31296855",
"30795892",
"29499136",
"28452979",
"6326058",
"3027511",
"1847365",
"6154941",
"6265785",
"6199039",
"6096352",
"29... | [
"An extended RNA binding surface through arrayed S1 and KH domains in transcription factor NusA.",
"The alpha subunit of E. coli RNA polymerase activates RNA binding by NusA.",
"Crystal structure of the transcription elongation/anti-termination factor NusA from Mycobacterium tuberculosis at 1.7 A resolution.",
... | [
2001,
2000,
2001,
2003,
2004,
2007,
2005,
2005,
1981,
2010,
1997,
2010,
2019,
2019,
2018,
2017,
1984,
1986,
1991,
1980,
1981,
1984,
1984,
1985,
1987,
1991,
1995,
2001,
2005,
1996,
1999,
1994
] | 32 | [
"IPR058582"
] | [] | 1 | 0 | 1 | [
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
23957,
75,
509
] | 3 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Domain | NusA, second KH domain, bacteria | NusA, second KH domain, bacteria | KH_NusA_2nd_bact | 5 |
IPR059161 | 59,161 | STOP2/WIP2-like, C2H2-type zinc finger | Znf-C2H2_STOP1/2_3rd | Domain | 5,500 | false | false | This domain is found in STOP 1 and 2 from Arabidopsis thaliana, WIP and similar sequences from plants. This domain is a C2H2 or β-β-α zinc finger DNA-binding domain. STOP1 (sensitive to proton rhizotoxicity 1) regulates transcription of multiple genes critical for tolerance to aluminum (Al) and low pH in Arabidopsis [ ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23115"
] | [
"zf-C2H2_STOP2_3rd"
] | [
5500
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00095772",
"PUB00095773",
"PUB00095774"
] | [
"23935008",
"17535918",
"19880795"
] | [
"STOP2 activates transcription of several genes for Al- and low pH-tolerance that are regulated by STOP1 in Arabidopsis.",
"Zinc finger protein STOP1 is critical for proton tolerance in Arabidopsis and coregulates a key gene in aluminum tolerance.",
"A zinc finger transcription factor ART1 regulates multiple ge... | [
2014,
2007,
2009
] | 3 | [] | [] | 0 | 0 | null | [
"Viridiplantae"
] | [
5500
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
35,
38,
41
] | 3 | true | Domain | STOP2/WIP2-like, C2H2-type zinc finger | STOP2/WIP2-like, C2H2-type zinc finger | Znf-C2H2_STOP1/2_3rd | 7 |
IPR059162 | 59,162 | RIIa domain-containing protein 1 | RIIAD1 | Domain | 799 | false | false | This entry includes uncharacterised RIIa domain-containing protein 1 (RIIAD1) in eukaryotes. | [] | [] | [] | 0 | [
"CDD"
] | [
"cd22971"
] | [
"DD_RIIAD1"
] | [
799
] | 1 | [] | [] | [] | 0 | [
"9d5n"
] | 1 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
799
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
4,
2,
1,
3
] | 5 | true | Domain | RIIa domain-containing protein 1 | RIIa domain-containing protein 1 | RIIAD1 | 2 |
IPR059164 | 59,164 | PRP39, C-terminal HAT repeat | HAT_PRP39_C | Repeat | 8,788 | false | false | This entry represents the C-terminal segment of the HAT (Half A TPR) repeat proteins including Pre-mRNA-processing factor 39, SART3, PRP42 and similar proteins. PRP39 is a component of the spliceosome that functions prior to stable branch point recognition by the U1 snRNP particle to facilitate or stabilize the U1 snRN... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF23241"
] | [
"HAT_PRP39_C"
] | [
8788
] | 1 | [
"REACTOME"
] | [
"R-DME-72163"
] | [
"REACTOME:R-DME-72163"
] | 1 | [
"5ctq",
"5ctr",
"5jjw",
"5jjx",
"5jpz",
"5zwn",
"6g70",
"6g90",
"6n7p",
"6n7r",
"6n7x",
"7oqc",
"7oqe",
"8w2o",
"9l5r",
"9l5s",
"9l5t"
] | 17 | [
"PUB00147913",
"PUB00161719"
] | [
"29051543",
"36316087"
] | [
"CryoEM structure of Saccharomyces cerevisiae U1 snRNP offers insight into alternative splicing.",
"Human PRPF39 is an alternative splicing factor recruiting U1 snRNP to weak 5' splice sites."
] | [
2017,
2022
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteroidota",
"Eukaryota"
] | [
5,
8783
] | 2 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
34,
1,
4,
3,
7,
4,
3,
9,
5,
2,
1,
37
] | 12 | true | Repeat | PRP39, C-terminal HAT repeat | PRP39, C-terminal HAT repeat | HAT_PRP39_C | 3 |
IPR059166 | 59,166 | PLD-like, catalytic domain | PLD-like_cat | Domain | 1,323 | false | false | This entry represents a putative catalytic domain of uncharacterised hypothetical proteins with similarity to phospholipase D (PLD, ). PLD enzymes hydrolyse phospholipid phosphodiester bonds to yield phosphatidic acid and a free polar head group. They can also catalyse transphosphatidylation of phospholipids to accepto... | [] | [] | [] | 0 | [
"CDD"
] | [
"cd09176"
] | [
"PLDc_unchar6"
] | [
1323
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00039849",
"PUB00113210"
] | [
"16247004",
"10425395"
] | [
"Structure of the metal-independent restriction enzyme BfiI reveals fusion of a specific DNA-binding domain with a nonspecific nuclease.",
"The PLD superfamily: insights into catalysis."
] | [
2005,
1999
] | 2 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Versovirus",
"ecological metagenomes"
] | [
28,
1271,
2,
6,
16
] | 5 | [] | [] | 0 | true | Domain | PLD-like, catalytic domain | PLD-like, catalytic domain | PLD-like_cat | 3 |
IPR059168 | 59,168 | PATE2-like, ECD 3FTx domain | PATE2-like_ECD_3FTx | Domain | 268 | false | false | This entry represents the extracellular domain (ECD) in Prostate and testis expressed protein 2 (PATE2). PATE2 is a member of the prostate and testis expression (PATE)-like family of proteins that likely play important roles in reproductive and neuronal physiology. This domain belongs to Ly-6 antigen/uPA receptor-like ... | [] | [] | [] | 0 | [
"CDD"
] | [
"cd23578"
] | [
"TFP_LU_ECD_PATE2"
] | [
268
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00070651",
"PUB00093810"
] | [
"18387948",
"22402205"
] | [
"PATE gene clusters code for multiple, secreted TFP/Ly-6/uPAR proteins that are expressed in reproductive and neuron-rich tissues and possess neuromodulatory activity.",
"Involvement of the prostate and testis expression (PATE)-like proteins in sperm-oocyte interaction."
] | [
2008,
2012
] | 2 | [
"IPR016054"
] | [] | 1 | 0 | 1 | [
"Theria"
] | [
268
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
6,
6
] | 3 | true | Domain | PATE2-like, ECD 3FTx domain | PATE2-like, ECD 3FTx domain | PATE2-like_ECD_3FTx | 2 |
IPR059169 | 59,169 | Gamma-tubulin complex component 5, N-terminal extension | GCP5_N_ext | Domain | 2,818 | false | false | This entry represents the N-terminal extension in GCP-5, also called TUBGCP5, a component of the gamma-tubulin ring complex (gamma-TuRC), which is necessary for microtubule nucleation at the centrosome. This N-terminal extension is involved in protein-protein interactions. GCP-5 binds Mozart1, a microprotein that regul... | [] | [] | [] | 0 | [
"CDD"
] | [
"cd22572"
] | [
"GCP5_NTD"
] | [
2818
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-380270",
"R-HSA-380320",
"R-MMU-380270",
"R-MMU-380320"
] | [
"REACTOME:R-HSA-380270",
"REACTOME:R-HSA-380320",
"REACTOME:R-MMU-380270",
"REACTOME:R-MMU-380320"
] | 4 | [
"6l81",
"6l82",
"6tf9",
"6v69",
"6v6s",
"7as4",
"7qj0",
"7qj1",
"7qj2",
"7qj3",
"7qj4",
"7qj5",
"7qj6",
"7qj7",
"7qj8",
"7qj9",
"7qja",
"7qjb",
"7qjc",
"7qjd",
"7qje",
"8q62",
"8rx1",
"8vrd",
"8vrj",
"8vrk",
"9eoj",
"9g3x",
"9g3y",
"9g3z",
"9i8g",
"9i8h"... | 36 | [
"PUB00091047",
"PUB00100105",
"PUB00150736"
] | [
"21725292",
"32610137",
"11694571"
] | [
"Crystal structure of γ-tubulin complex protein GCP4 provides insight into microtubule nucleation.",
"Promiscuous Binding of Microprotein Mozart1 to γ-Tubulin Complex Mediates Specific Subcellular Targeting to Control Microtubule Array Formation.",
"GCP5 and GCP6: two new members of the human gamma-tubulin comp... | [
2011,
2020,
2001
] | 3 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
2818
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus"
] | [
4,
2,
8,
3,
1,
3
] | 6 | true | Domain | Gamma-tubulin complex component 5, N-terminal extension | Gamma-tubulin complex component 5, N-terminal extension | GCP5_N_ext | 4 |
IPR059172 | 59,172 | Transcription regulatory protein SNF6 | SNF6 | Domain | 60 | false | false | This entry represents SNF6 a nuclear protein involved in transcriptional activation in Saccharomyces cerevisiae. It is a component of SWI/SNF complex, an ATP-dependent chromatin remodeling complex, which is required for the positive and negative regulation of gene expression of many genes. It changes chromatin structur... | [] | [] | [] | 0 | [
"CDD"
] | [
"cd22571"
] | [
"SNF6"
] | [
60
] | 1 | [] | [] | [] | 0 | [
"7c4j",
"7egm",
"7egp"
] | 3 | [
"PUB00118054",
"PUB00150734"
] | [
"12524530",
"2188093"
] | [
"Structural analysis of the yeast SWI/SNF chromatin remodeling complex.",
"SNF6 encodes a nuclear protein that is required for expression of many genes in Saccharomyces cerevisiae."
] | [
2003,
1990
] | 2 | [] | [] | 0 | 0 | null | [
"Saccharomycotina"
] | [
60
] | 1 | [
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)"
] | [
1
] | 1 | true | Domain | Transcription regulatory protein SNF6 | Transcription regulatory protein SNF6 | SNF6 | 1 |
IPR059176 | 59,176 | UDP-X diphosphatase-like, N-terminal oligomerisation domain | UDP-X_N | Domain | 3,322 | false | false | This entry represents an α-helical oligomerisation domain which is found at the N-terminal end of a number of phosphatases such as UDP-X diphosphatase from Streptococcus pneumoniae and CDP-Choline Pyrophosphatase from Bacillus cereus , and related bacterial proteins. This domain precedes the nudix domain and this arran... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF12535"
] | [
"Nudix_N"
] | [
3322
] | 1 | [] | [] | [] | 0 | [
"3o8s",
"3q1p",
"3q4i",
"4hfq",
"6nch",
"6nci"
] | 6 | [
"PUB00006662",
"PUB00056362",
"PUB00156222"
] | [
"8810257",
"21531795",
"23691178"
] | [
"The MutT proteins or \"Nudix\" hydrolases, a family of versatile, widely distributed, \"housecleaning\" enzymes.",
"The Nudix hydrolase CDP-chase, a CDP-choline pyrophosphatase, is an asymmetric dimer with two distinct enzymatic activities.",
"A UDP-X diphosphatase from Streptococcus pneumoniae hydrolyzes prec... | [
1996,
2011,
2013
] | 3 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Halobacteriales",
"Peduovirus P24C9",
"metagenomes"
] | [
3243,
4,
26,
1,
48
] | 5 | [] | [] | 0 | true | Domain | UDP-X diphosphatase-like, N-terminal oligomerisation domain | UDP-X diphosphatase-like, N-terminal oligomerisation domain | UDP-X_N | 3 |
IPR059177 | 59,177 | GH29D-like, beta-sandwich domain | GH29D-like_dom | Domain | 8,376 | false | false | This domain is found in AmGH29D fucosidase from A. muciniphila ( ) and in other bacterial proteins such as Endoglucanase from Clostridium saccharobutylicum ( ) and Beta-hexosaminidase from Porphyromonas gingivalis ( ). In these proteins, this domain is combined with distinct domains. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF13290"
] | [
"CHB_HEX_C_1"
] | [
8376
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Caudoviricetes",
"Eukaryota",
"unclassified sequences"
] | [
116,
7920,
13,
184,
143
] | 5 | [] | [] | 0 | true | Domain | GH29D-like, beta-sandwich domain | GH29D-like, beta-sandwich domain | GH29D-like_dom | 6 |
IPR059180 | 59,180 | YorM, 3D domain | 3D_YorM | Domain | 4,588 | false | false | This entry represents the 3D domain in SPbeta prophage-derived uncharacterized protein YorM which is encoded by the yorM gene within the SPbeta prophage region of Bacillus subtilis (strain 168). This short presumed domain contains three conserved aspartate residues, hence the name 3D. This conservation is suggestive of... | [] | [] | [] | 0 | [
"CDD"
] | [
"cd14667"
] | [
"3D_containing_proteins"
] | [
4588
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00033633"
] | [
"16139297"
] | [
"Crystal structure of MltA from Escherichia coli reveals a unique lytic transglycosylase fold."
] | [
2005
] | 1 | [
"IPR010611"
] | [] | 1 | 0 | 1 | [
"Bacteria",
"Eukaryota",
"Viruses",
"metagenomes"
] | [
4376,
25,
95,
92
] | 4 | [] | [] | 0 | true | Domain | YorM, 3D domain | YorM, 3D domain | 3D_YorM | 3 |
IPR059181 | 59,181 | RWDD2A/B, C-terminal domain | RWDD2A-B_C | Domain | 3,658 | false | false | This entry represents the C-terminal in RWDD2A and RWDD2B which are small proteins that contain an N-terminal RWD domain. The C-terminal domain is predicted to adopt a fold similar to the C-terminal domain of Prp3, an essential U4/U6 di-snRNP-associated protein which plays a role in pre-mRNA splicing. The Prp3 C-termin... | [] | [] | [] | 0 | [
"CDD"
] | [
"cd24163"
] | [
"RWDD2_C"
] | [
3658
] | 1 | [
"REACTOME"
] | [
"R-MMU-3065678"
] | [
"REACTOME:R-MMU-3065678"
] | 1 | [] | 0 | [
"PUB00158498",
"PUB00158499",
"PUB00158500"
] | [
"32755071",
"36446526",
"27050411"
] | [
"Multi-Tissue Epigenetic and Gene Expression Analysis Combined With Epigenome Modulation Identifies RWDD2B as a Target of Osteoarthritis Susceptibility.",
"Transcriptome analyses in infertile men reveal germ cell-specific expression and splicing patterns.",
"Identification of Differentially Expressed Genes thro... | [
2021,
2023,
2016
] | 3 | [
"IPR010541"
] | [] | 1 | 0 | 1 | [
"Eukaryota"
] | [
3658
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus"
] | [
5,
1,
5,
3,
1,
5
] | 6 | true | Domain | RWDD2A/B, C-terminal domain | RWDD2A/B, C-terminal domain | RWDD2A-B_C | 1 |
IPR059182 | 59,182 | Kinesin heavy chain, C-terminal domain | Khc_C | Domain | 7,193 | false | false | This entry represents the C-terminal coiled coil in Drosophila kinesin heavy chain and Homo sapiens kinesin heavy chain. This entry also includes kinesin heavy chain isoform 5A (KIF5A, NKHC1) and kinesin heavy chain isoform 5C (KIF5C, NKHC2). This domain corresponds to the cargo binding region, which is responsible for... | [] | [] | [] | 0 | [
"CDD"
] | [
"cd23649"
] | [
"Khc_CBD_cc"
] | [
7193
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-CEL-6811434",
"R-CEL-983189",
"R-DME-6811434",
"R-DME-983189",
"R-HSA-2132295",
"R-HSA-264876",
"R-HSA-5625970",
"R-HSA-6811434",
"R-HSA-9725370",
"R-HSA-983189",
"R-MMU-2132295",
"R-MMU-5625970",
"R-MMU-6811434",
"R-MMU-983189",
"R-RNO-2132295",
"R-RNO-5625970",
"R-RNO-6811434",
... | [
"REACTOME:R-CEL-6811434",
"REACTOME:R-CEL-983189",
"REACTOME:R-DME-6811434",
"REACTOME:R-DME-983189",
"REACTOME:R-HSA-2132295",
"REACTOME:R-HSA-264876",
"REACTOME:R-HSA-5625970",
"REACTOME:R-HSA-6811434",
"REACTOME:R-HSA-9725370",
"REACTOME:R-HSA-983189",
"REACTOME:R-MMU-2132295",
"REACTOME:R-... | 18 | [
"7bjs",
"8rhb",
"8rhh",
"8rik",
"8riz"
] | 5 | [
"PUB00152335",
"PUB00158186",
"PUB00158187",
"PUB00158188"
] | [
"16717129",
"34140355",
"2522352",
"1384131"
] | [
"Axonal transport of mitochondria requires milton to recruit kinesin heavy chain and is light chain independent.",
"Molecular basis of mRNA transport by a kinesin-1-atypical tropomyosin complex.",
"A three-domain structure of kinesin heavy chain revealed by DNA sequence and microtubule binding analyses.",
"Ef... | [
2006,
2021,
1989,
1992
] | 4 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
7193
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus"
] | [
2,
7,
1,
26,
5,
1,
10
] | 7 | true | Domain | Kinesin heavy chain, C-terminal domain | Kinesin heavy chain, C-terminal domain | Khc_C | 8 |
IPR059185 | 59,185 | Small ribosomal subunit protein mS27, saccharomycetes | MRP13_sacc | Family | 58 | false | false | This entry represents Small ribosomal subunit protein mS27 (MRP13) found in saccharomycetes. MRP13 is a component of the mitochondrial small ribosomal subunit (mt-SSU) of Saccharomyces cerevisiae mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial geno... | [] | [] | [] | 0 | [
"CDD"
] | [
"cd23704"
] | [
"mS44"
] | [
58
] | 1 | [] | [] | [] | 0 | [
"5mrc",
"5mre",
"5mrf",
"8d8j",
"8d8k",
"8d8l",
"8om2",
"8om3",
"8om4"
] | 9 | [
"PUB00010175",
"PUB00089004",
"PUB00090932",
"PUB00098057",
"PUB00158253"
] | [
"12392552",
"25609543",
"9151978",
"28154081",
"3065621"
] | [
"Tag-mediated isolation of yeast mitochondrial ribosome and mass spectrometric identification of its new components.",
"Organization of the mitochondrial translation machinery studied in situ by cryoelectron tomography.",
"Identification and characterization of the genes for mitochondrial ribosomal proteins of ... | [
2002,
2015,
1997,
2017,
1988
] | 5 | [] | [] | 0 | 0 | null | [
"Saccharomycetes"
] | [
58
] | 1 | [
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)"
] | [
1
] | 1 | true | Family | Small ribosomal subunit protein mS27, saccharomycetes | Small ribosomal subunit protein mS27, saccharomycetes | MRP13_sacc | 1 |
IPR059186 | 59,186 | Exo-beta-1,3-glucanase | SACTE_4363 | Family | 3,180 | false | false | Exo-beta-1,3-glucanase (SACTE_4363, ) specifically hydrolyses laminarin and laminarioligosaccharides, producing glucose and laminaribiose as end products [ ]. It hydrolyses beta-1,3-glucan bonds via inversion of stereochemistry at the anomeric carbon. Structural studies reveal an extended substrate-binding cleft with s... | [] | [] | [] | 0 | [
"CDD"
] | [
"cd23669"
] | [
"GH55_SacteLam55A-like"
] | [
3180
] | 1 | [] | [] | [] | 0 | [
"4pew",
"4pex",
"4pey",
"4pez",
"4pf0",
"4tyv",
"4tz1",
"4tz3",
"4tz5"
] | 9 | [
"PUB00157290",
"PUB00157291",
"PUB00158226"
] | [
"29954113",
"25752603",
"28625980"
] | [
"Isolation of β-1,3-Glucanase-Producing Microorganisms from <i>Poria cocos</i> Cultivation Soil via Molecular Biology.",
"Active site and laminarin binding in glycoside hydrolase family 55.",
"Functional Analysis of a Novel β-(1,3)-Glucanase from Corallococcus sp. Strain EGB Containing a Fascin-Like Module."
] | [
2018,
2015,
2017
] | 3 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
2995,
181,
4
] | 3 | [] | [] | 0 | true | Family | Exo-beta-1,3-glucanase | Exo-beta-1,3-glucanase | SACTE_4363 | 3 |
IPR059188 | 59,188 | ClpX-like, zinc ribbon domain | Znf_CLPX-like | Domain | 26,803 | false | false | This entry represents a zinc ribbon domain which is found in the bacterial ATP-dependent Clp protease ATP-binding subunit ClpX (1/2/3) and the homologous animal mitochondrial ATP-dependent clpX-like chaperone. The ClpX heat shock protein of Escherichia coli is a member of the universally conserved Hsp100 family of prot... | [] | [] | [] | 0 | [
"PROFILE"
] | [
"PS51902"
] | [
"CLPX_ZB"
] | [
26803
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-9837999",
"R-MMU-9837999",
"R-RNO-9837999"
] | [
"REACTOME:R-HSA-9837999",
"REACTOME:R-MMU-9837999",
"REACTOME:R-RNO-9837999"
] | 3 | [
"1ovx",
"2ds5",
"2ds6",
"2ds7",
"2ds8",
"6sfw",
"6vfs",
"6vfx",
"8e91",
"8et3",
"9ndj",
"9pio",
"9pjd"
] | 13 | [
"PUB00011897",
"PUB00014077",
"PUB00014898",
"PUB00014969",
"PUB00035804",
"PUB00035805",
"PUB00035806",
"PUB00035807",
"PUB00035812",
"PUB00148681",
"PUB00150924",
"PUB00150925",
"PUB00161557",
"PUB00161558",
"PUB00161559",
"PUB00161560"
] | [
"12937164",
"12665246",
"11278349",
"14525985",
"17210253",
"15963892",
"15718139",
"10529348",
"11179890",
"22841477",
"11003706",
"22360725",
"11923310",
"22710082",
"25957689",
"28874591"
] | [
"The N-terminal zinc binding domain of ClpX is a dimerization domain that modulates the chaperone function.",
"Zinc fingers--folds for many occasions.",
"Structure-function analysis of the zinc-binding region of the Clpx molecular chaperone.",
"Solution structure of the dimeric zinc binding domain of the chap... | [
2003,
2002,
2001,
2003,
2007,
2005,
2005,
1999,
2001,
2012,
2000,
2012,
2002,
2012,
2015,
2017
] | 16 | [] | [
"IPR010603"
] | 0 | 1 | 0 | [
"Bacteria",
"Caudoviricetes",
"Eukaryota",
"Oxyplasma meridianum",
"unclassified sequences"
] | [
24245,
14,
2062,
1,
481
] | 5 | [
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
2,
1,
4,
5,
6
] | 6 | true | Domain | ClpX-like, zinc ribbon domain | ClpX-like, zinc ribbon domain | Znf_CLPX-like | 9 |
IPR059192 | 59,192 | PIN-like domain-containing protein | PIN_19 | Family | 74 | false | false | This entry represents uncharacterised PIN domain-containing proteins in bacteria. PIN-like domains can be classified into distinct groups; this subgroup corresponds to PIN_19, they belong to the VapC-like nucleases [ ]. The PIN domain-like superfamily comprises five major structural groups of nucleases that share a com... | [] | [] | [] | 0 | [
"CDD"
] | [
"cd18702"
] | [
"PIN_VapC_like"
] | [
74
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00091006"
] | [
"28575517"
] | [
"Comprehensive classification of the PIN domain-like superfamily."
] | [
2017
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"mine drainage metagenome"
] | [
73,
1
] | 2 | [] | [] | 0 | true | Family | PIN-like domain-containing protein | PIN-like domain-containing protein | PIN_19 | 8 |
IPR059193 | 59,193 | mt-LAF15-like | mt-LAF15-like | Family | 46 | false | false | mt-LAF15 ( ) is a Trypanosoma brucei mitochondrial large subunit (mt-LSU) assembly factor (mt-LAF). In an mt-LSU assembly intermediate during maturation of the L7/L12 stalk, mt-LAF15 and an additional protein, UNK6, form a protrusion similar to mtLSU factors bL10m:bL12m, and a protein module of mt-LAF15, mL75, and UNK6... | [] | [] | [] | 0 | [
"CDD"
] | [
"cd23089"
] | [
"mt-LAF15-like"
] | [
46
] | 1 | [] | [] | [] | 0 | [
"6yxx",
"6yxy",
"7aoi"
] | 3 | [
"PUB00157182"
] | [
"33576519"
] | [
"Interconnected assembly factors regulate the biogenesis of mitoribosomal large subunit."
] | [
2021
] | 1 | [] | [] | 0 | 0 | null | [
"Trypanosomatidae"
] | [
46
] | 1 | [] | [] | 0 | true | Family | mt-LAF15-like | mt-LAF15-like | mt-LAF15-like | 2 |
IPR059194 | 59,194 | Ribosomal protein mL96-like | mL96-like | Family | 42 | false | false | This entry represents uncharacterised proteins from Trypanosoma and Leishmania. Some of these proteins are annotated as Ribosomal protein mL96 ( ) which is a component of mitoribosomal large subunit (mtLSU) central protuberance (CP) in the Trypanosoma brucei mitochondrial ribosome (mitoribosome). This entry also includ... | [] | [] | [] | 0 | [
"CDD"
] | [
"cd23711"
] | [
"mL96"
] | [
42
] | 1 | [] | [] | [] | 0 | [
"6hiv",
"6hix",
"7aih",
"7ane"
] | 4 | [
"PUB00157638"
] | [
"30213880"
] | [
"Evolutionary shift toward protein-based architecture in trypanosomal mitochondrial ribosomes."
] | [
2018
] | 1 | [] | [] | 0 | 0 | null | [
"Metakinetoplastina"
] | [
42
] | 1 | [] | [] | 0 | true | Family | Ribosomal protein mL96-like | Ribosomal protein mL96-like | mL96-like | 4 |
IPR059196 | 59,196 | VscT2-like | VscT2-like | Domain | 52 | false | false | This entry represents putative Vibrio type III secretion system (T3SS) apparatus protein VscT2 ( ). Vibrios, which include over 100 species, are ubiquitous in marine and estuarine environments, and many species, such as Vibrio cholerae, V. parahaemolyticus and V. mimicus, are pathogens for humans. VscT2 co-occurs with ... | [] | [] | [] | 0 | [
"CDD"
] | [
"cd21871"
] | [
"VscT2"
] | [
52
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00146392",
"PUB00146393",
"PUB00146394"
] | [
"15728357",
"21110901",
"19193258"
] | [
"Genomic characterization of non-O1, non-O139 Vibrio cholerae reveals genes for a type III secretion system.",
"Presence of genes for type III secretion system 2 in Vibrio mimicus strains.",
"Epidemiology of Vibrio parahaemolyticus outbreaks, southern Chile."
] | [
2005,
2010,
2009
] | 3 | [] | [] | 0 | 0 | null | [
"Gammaproteobacteria"
] | [
52
] | 1 | [] | [] | 0 | true | Domain | VscT2-like | VscT2-like | VscT2-like | 4 |
IPR059199 | 59,199 | Ribosomal protein S23-like | mS23-like | Family | 41 | false | false | This entry represents uncharacterised proteins from Trypanosoma and Leishmania. mS23 ( ) is an uncharacterised mitochondrial protein from Trypanosoma cruzi. It is a component of T. cruzi mitochondrial ribosome (mitoribosome) small subunits (Tb-mt-SSUs), which forms a complex with the C-terminal domain of initiation fac... | [] | [] | [] | 0 | [
"CDD"
] | [
"cd23643"
] | [
"mS23"
] | [
41
] | 1 | [] | [] | [] | 0 | [
"6hiv",
"6hiw",
"6hiy",
"6sga",
"6sgb",
"7ane",
"7aor",
"7pua",
"7pub",
"9hny"
] | 10 | [
"PUB00157180",
"PUB00157181",
"PUB00157638"
] | [
"31515389",
"33168716",
"30213880"
] | [
"Mitoribosomal small subunit biogenesis in trypanosomes involves an extensive assembly machinery.",
"Structure of the mature kinetoplastids mitoribosome and insights into its large subunit biogenesis.",
"Evolutionary shift toward protein-based architecture in trypanosomal mitochondrial ribosomes."
] | [
2019,
2020,
2018
] | 3 | [] | [] | 0 | 0 | null | [
"Metakinetoplastina"
] | [
41
] | 1 | [] | [] | 0 | true | Family | Ribosomal protein S23-like | Ribosomal protein S23-like | mS23-like | 9 |
IPR059203 | 59,203 | APOBEC4, cytosine deaminase domain | APOBEC4_CD_dom | Domain | 408 | false | false | This entry represents the cytosine deaminase domain in APOBEC4. APOBEC4 belongs to the AID/APOBEC family. In mammals, APOBEC4 is expressed primarily in testis [ ]. The AID/APOBEC are deaminases that function in RNA/DNA editing. The AID/APOBEC family contains several subfamilies: AID, APOBEC1, APOBEC2, APOBEC3, APOBEC4 ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF18775"
] | [
"APOBEC4"
] | [
408
] | 1 | [
"EC",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"3.5.4.-",
"PWY-7081",
"R-HSA-72200",
"R-HSA-75094",
"R-MMU-72200",
"R-MMU-75094",
"R-RNO-72200",
"R-RNO-75094"
] | [
"EC:3.5.4.-",
"METACYC:PWY-7081",
"REACTOME:R-HSA-72200",
"REACTOME:R-HSA-75094",
"REACTOME:R-MMU-72200",
"REACTOME:R-MMU-75094",
"REACTOME:R-RNO-72200",
"REACTOME:R-RNO-75094"
] | 8 | [] | 0 | [
"PUB00057473",
"PUB00088592",
"PUB00088593",
"PUB00091285",
"PUB00161717"
] | [
"21890906",
"16082223",
"26608778",
"29555751",
"27283515"
] | [
"Evolution of the deaminase fold and multiple origins of eukaryotic editing and mutagenic nucleic acid deaminases from bacterial toxin systems.",
"APOBEC4, a new member of the AID/APOBEC family of polynucleotide (deoxy)cytidine deaminases predicted by computational analysis.",
"DNA Editing by APOBECs: A Genomic... | [
2011,
2005,
2016,
2018,
2016
] | 5 | [
"IPR002125"
] | [] | 1 | 0 | 1 | [
"Vertebrata"
] | [
408
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
1,
2
] | 3 | true | Domain | APOBEC4, cytosine deaminase domain | APOBEC4, cytosine deaminase domain | APOBEC4_CD_dom | 8 |
IPR059205 | 59,205 | Invertebrate-AID/APOBEC-deaminase | Inv-AAD | Family | 16 | false | false | A classical AID/APOBEC-like deaminases found in cnidarians [ ]. The AID/APOBEC are deaminases that function in RNA/DNA editing. The AID/APOBEC family contains several subfamilies: AID, APOBEC1, APOBEC2, APOBEC3, APOBEC4 and APOBEC5 [ , , ]. AID/APOBEC deaminases (AADs) convert cytidine to uridine in single-stranded nuc... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF18785"
] | [
"Inv-AAD"
] | [
16
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00088593",
"PUB00091285",
"PUB00161717"
] | [
"26608778",
"29555751",
"27283515"
] | [
"DNA Editing by APOBECs: A Genomic Preserver and Transformer.",
"Diversification of AID/APOBEC-like deaminases in metazoa: multiplicity of clades and widespread roles in immunity.",
"The APOBEC Protein Family: United by Structure, Divergent in Function."
] | [
2016,
2018,
2016
] | 3 | [] | [] | 0 | 0 | null | [
"Anthozoa"
] | [
16
] | 1 | [] | [] | 0 | true | Family | Invertebrate-AID/APOBEC-deaminase | Invertebrate-AID/APOBEC-deaminase | Inv-AAD | 4 |
IPR059206 | 59,206 | P-loop ATPase, Sll1717-like | Sll1717-like | Family | 1,629 | false | false | This entry represents a P-loop-containing ATPase (or possibly GTPase) protein family that includes Sll1717 from Synechocystis sp. ( ), which has has a predicted ATP/GTP-binding motif [ ]. Some members have been annotated as DNA repair protein, FunZ, but the function is unknown. Members often appear next to or fused to ... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF047389"
] | [
"ATPase_Sll1717"
] | [
1629
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00159258"
] | [
"16452410"
] | [
"Sll1717 affects the redox state of the plastoquinone pool by modulating quinol oxidase activity in thylakoids."
] | [
2006
] | 1 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Caudoviricetes",
"Opisthokonta",
"metagenomes"
] | [
9,
1597,
3,
3,
17
] | 5 | [
"Escherichia coli (strain K12)",
"Mus musculus"
] | [
1,
1
] | 2 | true | Family | P-loop ATPase, Sll1717-like | P-loop ATPase, Sll1717-like | Sll1717-like | 5 |
IPR059207 | 59,207 | Fatty acid synthase, SBS domain | SBS_FAS | Domain | 1,327 | false | false | This entry represents the SBS domain (Six-Stranded Beta Sheet) of Fatty Acid Synthase (FAS) from Mycobacterium smegmatis and related proteins found in Actinomycetes. This domain plays important roles in protein assembly and stability. It is composed of a meander β-sheet decorated with few helices ( ) [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF18094"
] | [
"SBS_FAS"
] | [
1327
] | 1 | [] | [] | [] | 0 | [
"4v8l",
"4v8v",
"4v8w",
"6gjc"
] | 4 | [
"PUB00040740",
"PUB00091619"
] | [
"16615916",
"23291528"
] | [
"Magnesium-induced assembly of a complete DNA polymerase catalytic complex.",
"7.5-A cryo-em structure of the mycobacterial fatty acid synthase."
] | [
2006,
2013
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"unclassified sequences"
] | [
1325,
2
] | 2 | [] | [] | 0 | true | Domain | Fatty acid synthase, SBS domain | Fatty acid synthase, SBS domain | SBS_FAS | 8 |
IPR059208 | 59,208 | F0F1 ATP synthase subunit alpha, putative | ATP_synth_asu_put | Family | 225 | false | false | This entry represents a group of uncharacterised proteins from Bacillus species that are predicted to be F0F1 ATP synthase subunit alpha. | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF005260"
] | [
"PRK06763.1"
] | [
225
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacillus"
] | [
225
] | 1 | [] | [] | 0 | true | Family | F0F1 ATP synthase subunit alpha, putative | F0F1 ATP synthase subunit alpha, putative | ATP_synth_asu_put | 4 |
IPR059209 | 59,209 | YdhT-like | YdhT-like | Family | 245 | false | false | This entry represents a group of uncharacterised proteins from enterobacterales, including the protein YdhT. | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF007410"
] | [
"PRK09946.1"
] | [
245
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Enterobacterales"
] | [
245
] | 1 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | YdhT-like | YdhT-like | YdhT-like | 8 |
IPR059210 | 59,210 | Methylation-associated defense system protein MAD4-like | MADS4-like | Family | 79 | false | false | This entry represents a group of uncharacterised bacterial proteins related to Mad4, a predicted protein that belongs to ( ) [ ]. | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF047734"
] | [
"antiphage_MADS4"
] | [
79
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00159606"
] | [
"39094583"
] | [
"The bacterial defense system MADS interacts with CRISPR-Cas to limit phage infection and escape."
] | [
2024
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"bioreactor metagenome"
] | [
78,
1
] | 2 | [] | [] | 0 | true | Family | Methylation-associated defense system protein MAD4-like | Methylation-associated defense system protein MAD4-like | MADS4-like | 5 |
IPR059211 | 59,211 | BOW99_gp33-like | BOW99_gp33-like | Family | 119 | false | false | Members of this family of small proteins occur in phage genomes and prophage regions of bacterial genomes, including BOW99_gp33 from Streptococcus phage phiARI0462 ( ) and some members of the human bacterial microbiome [ ]. The function is unknown. | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF047423"
] | [
"BOW99_gp33_fam"
] | [
119
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00105396"
] | [
"31402174"
] | [
"Large-Scale Analyses of Human Microbiomes Reveal Thousands of Small, Novel Genes."
] | [
2019
] | 1 | [] | [] | 0 | 0 | null | [
"Bacillota",
"Caudoviricetes"
] | [
95,
24
] | 2 | [] | [] | 0 | true | Family | BOW99_gp33-like | BOW99_gp33-like | BOW99_gp33-like | 8 |
IPR059212 | 59,212 | TIMELESS, tri-helical helix-turn-helix domain | HTH_TIMELESS | Domain | 1,991 | false | false | This helix-turn-helix (HTH) domain is found twice in human Protein timeless homolog (TIMELESS), which plays an important role in the control of DNA replication, maintenance of replication fork stability, maintenance of genome stability throughout normal DNA replication, DNA repair and in the regulation of the circadian... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF26019"
] | [
"HTH_TIMELESS"
] | [
1991
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-DME-432395",
"R-DME-432490",
"R-DME-432501",
"R-DME-432553",
"R-DME-432620",
"R-DME-538898",
"R-HSA-5693607",
"R-MMU-5693607",
"R-RNO-5693607"
] | [
"REACTOME:R-DME-432395",
"REACTOME:R-DME-432490",
"REACTOME:R-DME-432501",
"REACTOME:R-DME-432553",
"REACTOME:R-DME-432620",
"REACTOME:R-DME-538898",
"REACTOME:R-HSA-5693607",
"REACTOME:R-MMU-5693607",
"REACTOME:R-RNO-5693607"
] | 9 | [
"6t9q",
"6taz",
"7pfo",
"7plo",
"8b9d",
"8dd7",
"8ouw"
] | 7 | [
"PUB00008650",
"PUB00016387",
"PUB00045036",
"PUB00093466",
"PUB00097687",
"PUB00097689",
"PUB00097690",
"PUB00097691",
"PUB00097692",
"PUB00151996",
"PUB00161282",
"PUB00161283",
"PUB00161284",
"PUB00161285",
"PUB00161286",
"PUB00161287",
"PUB00161288",
"PUB00161289",
"PUB001612... | [
"11710984",
"15367656",
"12944972",
"26344098",
"19819872",
"23418588",
"10417378",
"10899011",
"32469068",
"35585232",
"32705708",
"23359676",
"9856465",
"10963667",
"10428031",
"12875843",
"31138685",
"12827206",
"15691769",
"15798197"
] | [
"Flies, clocks and evolution.",
"Swi1 and Swi3 are components of a replication fork protection complex in fission yeast.",
"S-phase checkpoint proteins Tof1 and Mrc1 form a stable replication-pausing complex.",
"Timeless Interacts with PARP-1 to Promote Homologous Recombination Repair.",
"Csm3, Tof1, and Mr... | [
2001,
2004,
2003,
2015,
2009,
2013,
1999,
2000,
2020,
2022,
2020,
2013,
1998,
2000,
1999,
2003,
2019,
2003,
2005,
2005
] | 20 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1991
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
2,
6,
3,
2,
4
] | 6 | true | Domain | TIMELESS, tri-helical helix-turn-helix domain | TIMELESS, tri-helical helix-turn-helix domain | HTH_TIMELESS | 2 |
IPR059213 | 59,213 | Killing protein KilR | KilR | Family | 234 | false | false | This entry represents Killing protein KilR from Escherichia coli and similar sequences from enterobacterales. KilR causes inhibition of cell division. At high levels of expression, it can also abolish the rod shape of the cells. Division inhibition by KilR can be relieved by overexpression of the cell division protein ... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF008465"
] | [
"PRK11354.1"
] | [
234
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00161723"
] | [
"8752325"
] | [
"Identification of a new inhibitor of essential division gene ftsZ as the kil gene of defective prophage Rac."
] | [
1996
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Caudoviricetes"
] | [
230,
4
] | 2 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Killing protein KilR | Killing protein KilR | KilR | 7 |
IPR059214 | 59,214 | MSC_0882-like | MSC_0882-like | Family | 240 | false | false | This entry represents a group of uncharacterised proteins from mycoplasmatota, including MSC_0882 from Mycoplasma mycoides ( ). | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"NF045846"
] | [
"MSC0882_dom"
] | [
240
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Mycoplasmatota",
"Zophobas morio"
] | [
238,
2
] | 2 | [] | [] | 0 | true | Family | MSC_0882-like | MSC_0882-like | MSC_0882-like | 6 |
IPR059215 | 59,215 | DNA topoisomerase 2-binding protein 1-like, second BRCT domain | BRCT2_TopBP1-like | Domain | 4,928 | false | false | TopBP1, also termed DNA topoisomerase II-beta-binding protein 1, or DNA topoisomerase II-binding protein 1, functions in DNA replication and damage response. It binds double-stranded DNA breaks and nicks as well as single-stranded DNA. TopBP1 contains six copies of BRCT domain. This entry corresponds to the second BRCT... | [] | [] | [] | 0 | [
"CDD"
] | [
"cd17731"
] | [
"BRCT_TopBP1_rpt2_like"
] | [
4928
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-5685938",
"R-HSA-5693607",
"R-HSA-5693616",
"R-HSA-6804756",
"R-HSA-69473",
"R-HSA-9709570",
"R-MMU-5685938",
"R-MMU-5693607",
"R-MMU-6804756",
"R-MMU-69473"
] | [
"REACTOME:R-HSA-5685938",
"REACTOME:R-HSA-5693607",
"REACTOME:R-HSA-5693616",
"REACTOME:R-HSA-6804756",
"REACTOME:R-HSA-69473",
"REACTOME:R-HSA-9709570",
"REACTOME:R-MMU-5685938",
"REACTOME:R-MMU-5693607",
"REACTOME:R-MMU-6804756",
"REACTOME:R-MMU-69473"
] | 10 | [
"2xnh",
"2xnk",
"3olc",
"6hm5",
"6rml"
] | 5 | [
"PUB00057784",
"PUB00062125",
"PUB00062126",
"PUB00062241",
"PUB00139687"
] | [
"19937654",
"15075294",
"16530042",
"21659603",
"15138768"
] | [
"Insights from the crystal structure of the sixth BRCT domain of topoisomerase IIbeta binding protein 1.",
"TopBP1 recruits Brg1/Brm to repress E2F1-induced apoptosis, a novel pRb-independent and E2F1-specific control for cell survival.",
"TopBP1 activates the ATR-ATRIP complex.",
"A DNA damage response scree... | [
2010,
2004,
2006,
2011,
2004
] | 5 | [
"IPR001357"
] | [] | 1 | 0 | 1 | [
"Eukaryota"
] | [
4928
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
18,
2,
4,
5,
4,
1,
1,
4,
3,
13
] | 10 | true | Domain | DNA topoisomerase 2-binding protein 1-like, second BRCT domain | DNA topoisomerase 2-binding protein 1-like, second BRCT domain | BRCT2_TopBP1-like | 9 |
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