interpro_id string | interpro_numeric_id int64 | name string | short_name string | entry_type string | protein_count int64 | is_llm bool | is_llm_reviewed bool | abstract string | go_ids list | go_terms list | go_categories list | go_count int64 | member_databases list | member_accessions list | member_names list | member_protein_counts list | member_count int64 | external_databases list | external_accessions list | external_xrefs list | external_xref_count int64 | pdb_ids list | structure_count int64 | publication_ids list | pubmed_ids list | publication_titles list | publication_years list | publication_count int64 | parent_ids list | child_ids list | parent_count int64 | child_count int64 | tree_depth float64 | taxonomy_names list | taxonomy_protein_counts list | taxonomy_count int64 | key_species_names list | key_species_protein_counts list | key_species_count int64 | in_entry_list bool | entry_list_type string | entry_list_name string | names_dat_name string | short_names_dat_name string | split_bucket int64 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
IPR005881 | 5,881 | Serine O-acetyltransferase | Ser_O-AcTrfase | Family | 22,565 | false | false | The biosynthesis of L-cysteine is the predominant way by which inorganic sulphur is incorporated into organic compounds. In this process, the most abundant utilizable source of sulphur, inorganic sulphate, is taken up and reduced to sulphide. Sulphide is used to produce L-cysteine, which serves for protein synthesis or... | [
"GO:0009001",
"GO:0006535",
"GO:0005737"
] | [
"serine O-acetyltransferase activity",
"L-cysteine biosynthetic process from L-serine",
"cytoplasm"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PIRSF",
"NCBIFAM"
] | [
"PIRSF000441",
"TIGR01172"
] | [
"CysE",
"cysE"
] | [
11663,
18062
] | 2 | [
"EC",
"GP",
"GP",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"REACTOME"
] | [
"2.3.1.30",
"GenProp0218",
"GenProp1301",
"PWY-6936",
"PWY-7274",
"PWY-7870",
"PWY-8071",
"R-MTU-936721"
] | [
"EC:2.3.1.30",
"GP:GenProp0218",
"GP:GenProp1301",
"METACYC:PWY-6936",
"METACYC:PWY-7274",
"METACYC:PWY-7870",
"METACYC:PWY-8071",
"REACTOME:R-MTU-936721"
] | 8 | [
"1s80",
"1ssm",
"1ssq",
"1sst",
"1t3d",
"3gvd",
"3mc4",
"4h7o",
"4hzc",
"4hzd",
"4n69",
"4n6a",
"4n6b",
"6jvu",
"6wye",
"7e3y",
"7ra4",
"8i04",
"8i06",
"8i09"
] | 20 | [] | [] | [] | [] | 0 | [] | [
"IPR024027"
] | 0 | 1 | 0 | [
"Archaea",
"Bacteria",
"Caudoviricetes",
"Eukaryota",
"unclassified sequences"
] | [
306,
19881,
9,
2068,
301
] | 5 | [
"Arabidopsis thaliana",
"Escherichia coli (strain K12)",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
15,
2,
5,
11
] | 4 | true | Family | Serine O-acetyltransferase | Serine O-acetyltransferase | Ser_O-AcTrfase | 7 |
IPR005882 | 5,882 | Bifunctional protein GlmU | Bifunctional_GlmU | Family | 20,795 | false | false | N-Acetylglucosamine-1-PO(4) uridyltransferase (GlmU, ) is a trimeric bifunctional enzyme that catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-GlcNAc. The X-ray crystal structure of Escherichia coli GlmU in complex with UDP-GlcNAc and CoA has been determined to 2.1 A resolution an... | [
"GO:0000287",
"GO:0003977",
"GO:0019134",
"GO:0000902",
"GO:0006048",
"GO:0009252",
"GO:0005737"
] | [
"magnesium ion binding",
"UDP-N-acetylglucosamine diphosphorylase activity",
"glucosamine-1-phosphate N-acetyltransferase activity",
"cell morphogenesis",
"UDP-N-acetylglucosamine biosynthetic process",
"peptidoglycan biosynthetic process",
"cytoplasm"
] | [
"molecular_function",
"molecular_function",
"molecular_function",
"biological_process",
"biological_process",
"biological_process",
"cellular_component"
] | 7 | [
"HAMAP",
"NCBIFAM"
] | [
"MF_01631",
"TIGR01173"
] | [
"GlmU",
"glmU"
] | [
20672,
20717
] | 2 | [
"EC",
"EC",
"GP",
"GP",
"GP",
"METACYC"
] | [
"2.3.1.157",
"2.7.7.23",
"GenProp0750",
"GenProp1443",
"GenProp1623",
"PWY-5514"
] | [
"EC:2.3.1.157",
"EC:2.7.7.23",
"GP:GenProp0750",
"GP:GenProp1443",
"GP:GenProp1623",
"METACYC:PWY-5514"
] | 6 | [
"1fwy",
"1fxj",
"1g95",
"1g97",
"1hm0",
"1hm8",
"1hm9",
"1hv9",
"2oi5",
"2oi6",
"2oi7",
"2qkx",
"2v0h",
"2v0i",
"2v0j",
"2v0k",
"2v0l",
"2vd4",
"2w0v",
"2w0w",
"3d8v",
"3d98",
"3dj4",
"3dk5",
"3foq",
"3fww",
"3spt",
"3st8",
"4aaw",
"4ac3",
"4e1k",
"4fce"... | 51 | [
"PUB00007906"
] | [
"11329257"
] | [
"Structure of the Escherichia coli GlmU pyrophosphorylase and acetyltransferase active sites."
] | [
2001
] | 1 | [
"IPR050065"
] | [] | 1 | 0 | 1 | [
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
20456,
35,
304
] | 3 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Bifunctional protein GlmU | Bifunctional protein GlmU | Bifunctional_GlmU | 8 |
IPR005883 | 5,883 | Type IV pilus inner membrane component PilM | PilM | Family | 11,656 | false | false | Bacterial type IV pili are surface filaments critical for diverse biological processes including surface and host cell adhesion, colonisation, biofilm formation, twitching motility, DNA uptake during natural transformation and virulence [ , ]. The proteins necessary to form the type IV pili inner-membrane complex, are ... | [] | [] | [] | 0 | [
"PFAM",
"PIRSF",
"NCBIFAM"
] | [
"PF11104",
"PIRSF019169",
"TIGR01175"
] | [
"PilM_2",
"PilM",
"pilM"
] | [
11655,
6988,
7015
] | 3 | [] | [] | [] | 0 | [
"2ych",
"3jc8",
"3jc9",
"5eou",
"5eox",
"5eoy",
"5eq6"
] | 7 | [
"PUB00017642",
"PUB00056929",
"PUB00059721",
"PUB00066717",
"PUB00066718",
"PUB00094564",
"PUB00094575"
] | [
"7565110",
"21596754",
"19857646",
"8550460",
"16857013",
"27022027",
"19857645"
] | [
"Characterization of a five-gene cluster required for the biogenesis of type 4 fimbriae in Pseudomonas aeruginosa.",
"Structure of the PilM-PilN inner membrane type IV pilus biogenesis complex from Thermus thermophilus.",
"Periplasmic domains of Pseudomonas aeruginosa PilN and PilO form a stable heterodimeric c... | [
1995,
2011,
2009,
1996,
2006,
2016,
2009
] | 7 | [] | [
"IPR054809"
] | 0 | 1 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
8,
11332,
12,
304
] | 4 | [] | [] | 0 | true | Family | Type IV pilus inner membrane component PilM | Type IV pilus inner membrane component PilM | PilM | 7 |
IPR005884 | 5,884 | Fumarate reductase, flavoprotein subunit | Fum_red_fp | Family | 2,140 | false | false | In bacteria two distinct, membrane-bound, enzyme complexes are responsible for the interconversion of fumarate and succinate ( ): fumaratereductase (Frd) is used in anaerobic growth, and succinate dehydrogenase (Sdh) is used in aerobic growth. Both complexes consist of two main components: a membrane-extrinsic componen... | [
"GO:0016491",
"GO:0009061"
] | [
"oxidoreductase activity",
"anaerobic respiration"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"NCBIFAM"
] | [
"TIGR01176"
] | [
"fum_red_Fp"
] | [
2140
] | 1 | [
"EC",
"GP",
"GP",
"GP",
"GP",
"GP",
"GP",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC"
] | [
"1.3.5.1",
"GenProp0756",
"GenProp1143",
"GenProp1267",
"GenProp1391",
"GenProp1537",
"GenProp1672",
"PWY-3781",
"PWY-4302",
"PWY-5392",
"PWY-561",
"PWY-5690",
"PWY-5913",
"PWY-6728",
"PWY-6969",
"PWY-7254",
"PWY-7279",
"PWY-7384",
"PWY-8086"
] | [
"EC:1.3.5.1",
"GP:GenProp0756",
"GP:GenProp1143",
"GP:GenProp1267",
"GP:GenProp1391",
"GP:GenProp1537",
"GP:GenProp1672",
"METACYC:PWY-3781",
"METACYC:PWY-4302",
"METACYC:PWY-5392",
"METACYC:PWY-561",
"METACYC:PWY-5690",
"METACYC:PWY-5913",
"METACYC:PWY-6728",
"METACYC:PWY-6969",
"META... | 19 | [
"1kf6",
"1kfy",
"1l0v",
"2b76",
"3cir",
"3p4p",
"3p4q",
"3p4r",
"3p4s",
"4kx6",
"5vpn",
"6awf",
"6b58"
] | 13 | [
"PUB00002503",
"PUB00002711"
] | [
"2668268",
"1375942"
] | [
"Fumarate reductase mutants of Escherichia coli that lack covalently bound flavin.",
"The sequence of the flavoprotein subunit of bovine heart succinate dehydrogenase."
] | [
1989,
1992
] | 2 | [
"IPR014006"
] | [] | 1 | 0 | 1 | [
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
2126,
3,
11
] | 3 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Fumarate reductase, flavoprotein subunit | Fumarate reductase, flavoprotein subunit | Fum_red_fp | 9 |
IPR005885 | 5,885 | tRNA guanine(10)-N2-dimethyltransferase | TrmG10 | Family | 146 | false | false | TrmG10 (tRNA (guanine(10)-N2)-dimethyltransferase or tRNA:G10 dimethyltransferase) catalyses the adenosylmethionine-dependent methylation of the exocyclic amino group (N(2)) of guanosine located at position 10. This enzyme is found in eukaryotes and archaea, but never in bacteria. It consists of a S-adenosylmethionine-... | [
"GO:0160102",
"GO:0030488"
] | [
"tRNA (guanine(10)-N2)-methyltransferase activity",
"tRNA methylation"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"NCBIFAM"
] | [
"TIGR01177"
] | [
""
] | [
146
] | 1 | [
"EC"
] | [
"2.1.1.213"
] | [
"EC:2.1.1.213"
] | 1 | [
"5e71",
"5e72",
"6zxv",
"6zxw",
"6zxy"
] | 5 | [
"PUB00074050"
] | [
"15210688"
] | [
"N2-methylation of guanosine at position 10 in tRNA is catalyzed by a THUMP domain-containing, S-adenosylmethionine-dependent methyltransferase, conserved in Archaea and Eukaryota."
] | [
2004
] | 1 | [] | [] | 0 | 0 | null | [
"Archaea",
"bioreactor metagenome"
] | [
145,
1
] | 2 | [] | [] | 0 | true | Family | tRNA guanine(10)-N2-dimethyltransferase | tRNA guanine(10)-N2-dimethyltransferase | TrmG10 | 4 |
IPR005886 | 5,886 | UDP-glucose 4-epimerase | UDP_G4E | Family | 37,603 | false | false | UDP-glucose 4-epimerase ( , also known as UDP-galactose 4-epimerase) interconverts UDP-glucose and UDP-galactose which are precursors of glucose-and galactose-containing exopolysaccharides (EPS) [ ]. Arabidopsis thaliana has five genes encoding functional UDP-D-glucose/UDP-D-galactose 4-epimerase [ ]. A set of related ... | [
"GO:0003978",
"GO:0006012"
] | [
"UDP-glucose 4-epimerase activity",
"galactose metabolic process"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"NCBIFAM",
"CDD"
] | [
"TIGR01179",
"cd05247"
] | [
"galE",
"UDP_G4E_1_SDR_e"
] | [
37207,
33237
] | 2 | [
"EC",
"EC",
"GP",
"GP",
"GP",
"GP",
"GP",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"5.1.3",
"5.1.3.2",
"GenProp0143",
"GenProp1310",
"GenProp1459",
"GenProp1648",
"GenProp1661",
"PWY-3821",
"PWY-6317",
"PWY-6397",
"PWY-6527",
"PWY-7328",
"PWY-7344",
"R-CEL-70370",
"R-DDI-70370",
"R-DME-70370",
"R-HSA-5609977",
"R-HSA-70370",
"R-MMU-70370",
"R-RNO-70370",
"R... | [
"EC:5.1.3",
"EC:5.1.3.2",
"GP:GenProp0143",
"GP:GenProp1310",
"GP:GenProp1459",
"GP:GenProp1648",
"GP:GenProp1661",
"METACYC:PWY-3821",
"METACYC:PWY-6317",
"METACYC:PWY-6397",
"METACYC:PWY-6527",
"METACYC:PWY-7328",
"METACYC:PWY-7344",
"REACTOME:R-CEL-70370",
"REACTOME:R-DDI-70370",
"R... | 22 | [
"1a9y",
"1a9z",
"1ek5",
"1ek6",
"1gy8",
"1hzj",
"1i3k",
"1i3l",
"1i3m",
"1i3n",
"1kvq",
"1kvr",
"1kvs",
"1kvt",
"1kvu",
"1lrj",
"1lrk",
"1lrl",
"1nah",
"1nai",
"1uda",
"1udb",
"1udc",
"1xel",
"1z45",
"2c20",
"2cnb",
"2udp",
"3enk",
"4lis",
"4twr",
"4wok"... | 45 | [
"PUB00083158",
"PUB00083159"
] | [
"16644739",
"12788721"
] | [
"Distinct properties of the five UDP-D-glucose/UDP-D-galactose 4-epimerase isoforms of Arabidopsis thaliana.",
"Unusual organization for lactose and galactose gene clusters in Lactobacillus helveticus."
] | [
2006,
2003
] | 2 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
57,
28735,
8459,
23,
329
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
33,
1,
2,
3,
1,
4,
1,
1,
11,
4,
1,
2,
51
] | 13 | true | Family | UDP-glucose 4-epimerase | UDP-glucose 4-epimerase | UDP_G4E | 6 |
IPR005887 | 5,887 | Glycosyl hydrolase family 92, alpha-1,2-mannosidase, putative | GH92_a_mannosidase_put | Family | 21,872 | false | false | This entry represents a group of glycosyl hydrolases (glycosidases) from bacteria and fungi, including members characterised as mannosidases with various fine specificities [ , ]. Most members of this family appear to have signal sequences and may, like the Microbacterium sp. M-90 protein, be secreted. | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"TIGR01180"
] | [
"aman2_put"
] | [
21872
] | 1 | [] | [] | [] | 0 | [
"2wvx",
"2wvy",
"2wvz",
"2ww0",
"2ww1",
"2ww2",
"2ww3",
"2wzs",
"5swi",
"6dwo",
"6f8z",
"6f90",
"6f91",
"6f92",
"7fe1",
"7fe2",
"7nsn",
"7zgm"
] | 18 | [
"PUB00034755",
"PUB00054400"
] | [
"8149382",
"20081828"
] | [
"A 1,2-alpha-D-mannosidase from a Bacillus sp.: purification, characterization, and mode of action.",
"Mechanistic insights into a Ca2+-dependent family of alpha-mannosidases in a human gut symbiont."
] | [
1994,
2010
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Siphoviridae sp. ctBLh2",
"unclassified sequences"
] | [
17845,
3901,
2,
124
] | 4 | [
"Arabidopsis thaliana",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)"
] | [
1,
1
] | 2 | true | Family | Glycosyl hydrolase family 92, alpha-1,2-mannosidase, putative | Glycosyl hydrolase family 92, alpha-1,2-mannosidase, putative | GH92_a_mannosidase_put | 8 |
IPR005888 | 5,888 | dTDP-glucose 4,6-dehydratase | dTDP_Gluc_deHydtase | Family | 29,233 | false | false | The conversion of dTDP-glucose into dTDP-4-keto-6-deoxyglucose by Escherichia coli dTDP-glucose 4,6-dehydratase takes place in the active site in three steps: dehydrogenation to dTDP-4-ketoglucose, dehydration to dTDP-4-ketoglucose-5,6-ene, and rereduction of C6 to the methyl group. The 4,6-dehydratase makes use of tig... | [
"GO:0008460",
"GO:0009225"
] | [
"dTDP-glucose 4,6-dehydratase activity",
"nucleotide-sugar metabolic process"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"NCBIFAM",
"CDD"
] | [
"TIGR01181",
"cd05246"
] | [
"dTDP_gluc_dehyt",
"dTDP_GD_SDR_e"
] | [
25230,
29215
] | 2 | [
"EC",
"GP",
"GP",
"GP",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC"
] | [
"4.2.1.46",
"GenProp0950",
"GenProp1403",
"GenProp1713",
"PWY-6808",
"PWY-6942",
"PWY-6953",
"PWY-6973",
"PWY-6974",
"PWY-6976",
"PWY-7104",
"PWY-7301",
"PWY-7312",
"PWY-7315",
"PWY-7316",
"PWY-7318",
"PWY-7413",
"PWY-7414",
"PWY-7440",
"PWY-7657",
"PWY-7688",
"PWY-7814",
... | [
"EC:4.2.1.46",
"GP:GenProp0950",
"GP:GenProp1403",
"GP:GenProp1713",
"METACYC:PWY-6808",
"METACYC:PWY-6942",
"METACYC:PWY-6953",
"METACYC:PWY-6973",
"METACYC:PWY-6974",
"METACYC:PWY-6976",
"METACYC:PWY-7104",
"METACYC:PWY-7301",
"METACYC:PWY-7312",
"METACYC:PWY-7315",
"METACYC:PWY-7316",... | 23 | [
"1bxk",
"1g1a",
"1kep",
"1ker",
"1ket",
"1keu",
"1kew",
"1oc2",
"1r66",
"1r6d",
"2hun",
"6bi4",
"6vlo",
"8du1",
"8shh",
"8sk0"
] | 16 | [
"PUB00007907"
] | [
"11851427"
] | [
"Concerted and stepwise dehydration mechanisms observed in wild-type and mutated Escherichia coli dTDP-glucose 4,6-dehydratase."
] | [
2002
] | 1 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
415,
24479,
3924,
46,
369
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
8,
1,
4,
2,
1,
3,
2,
3,
1,
19
] | 10 | true | Family | dTDP-glucose 4,6-dehydratase | dTDP-glucose 4,6-dehydratase | dTDP_Gluc_deHydtase | 9 |
IPR005889 | 5,889 | Nitrate transport permease | NtrB | Family | 3,458 | false | false | ABC transporters belong to the ATP-Binding Cassette (ABC) superfamily, which uses the hydrolysis of ATP to energise diverse biological systems. ABC transporters minimally consist of two conserved regions: a highly conserved ATP binding cassette (ABC) and a less conserved transmembrane domain (TMD). These can be found o... | [
"GO:0015112",
"GO:0015706",
"GO:0016020"
] | [
"nitrate transmembrane transporter activity",
"nitrate transmembrane transport",
"membrane"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"NCBIFAM"
] | [
"TIGR01183"
] | [
"ntrB"
] | [
3458
] | 1 | [] | [] | [] | 0 | [
"8w9m",
"8wm7",
"8wm8"
] | 3 | [
"PUB00004290",
"PUB00014769",
"PUB00017894",
"PUB00017895",
"PUB00017896",
"PUB00017897",
"PUB00017898",
"PUB00017899",
"PUB00025109",
"PUB00026406",
"PUB00043654"
] | [
"9872322",
"9873074",
"11421269",
"1282354",
"9640644",
"11988180",
"11470432",
"11402022",
"11080142",
"11532960",
"11421270"
] | [
"Crystal structure of the ATP-binding subunit of an ABC transporter.",
"Getting in or out: early segregation between importers and exporters in the evolution of ATP-binding cassette (ABC) transporters.",
"ABC transporters: physiology, structure and mechanism--an overview.",
"ABC transporters: from microorgani... | [
1998,
1999,
2001,
1992,
1998,
2002,
2001,
2001,
2000,
2001,
2001
] | 11 | [] | [] | 0 | 0 | null | [
"Bacteria",
"metagenomes"
] | [
3436,
22
] | 2 | [] | [] | 0 | true | Family | Nitrate transport permease | Nitrate transport permease | NtrB | 8 |
IPR005891 | 5,891 | DevC protein | DevC | Family | 1,808 | false | false | This family contains a predicted membrane subunit, DevC, of an ABC transporter known so far from two species of cyanobacteria. Some experimental data from mutational analysis [ ] suggest that this protein, along with DevA and DevB encoded in the same operon, may be involved in the transport/export of glycolipids. ABC t... | [] | [] | [] | 0 | [
"PIRSF",
"NCBIFAM"
] | [
"PIRSF031773",
"TIGR01185"
] | [
"DevC",
"devC"
] | [
1795,
1303
] | 2 | [
"GP"
] | [
"GenProp0649"
] | [
"GP:GenProp0649"
] | 1 | [] | 0 | [
"PUB00004290",
"PUB00007908",
"PUB00014769",
"PUB00017894",
"PUB00017895",
"PUB00017896",
"PUB00017897",
"PUB00017898",
"PUB00017899",
"PUB00025109",
"PUB00026406",
"PUB00043654"
] | [
"9872322",
"9570404",
"9873074",
"11421269",
"1282354",
"9640644",
"11988180",
"11470432",
"11402022",
"11080142",
"11532960",
"11421270"
] | [
"Crystal structure of the ATP-binding subunit of an ABC transporter.",
"The DevBCA exporter is essential for envelope formation in heterocysts of the cyanobacterium Anabaena sp. strain PCC 7120.",
"Getting in or out: early segregation between importers and exporters in the evolution of ATP-binding cassette (ABC... | [
1998,
1998,
1999,
2001,
1992,
1998,
2002,
2001,
2001,
2000,
2001,
2001
] | 12 | [] | [] | 0 | 0 | null | [
"Bacteria",
"ecological metagenomes"
] | [
1806,
2
] | 2 | [] | [] | 0 | true | Family | DevC protein | DevC protein | DevC | 6 |
IPR005892 | 5,892 | Glycine betaine/proline betaine transport system ATP-binding protein ProV-like | Gly-betaine_transp_ATP-bd | Family | 18,365 | false | false | This family represents the ATP binding subunit of a subfamily of ABC transporters, including ProV (for glycine betaine and proline betaine transport, [ ]), OpuBA (choline, [ ]), OpuCA (carnitine, [ ]), GbuA (glycine betaine and carnitine, [ ]) and OusV (glycine betaine and choline, [ ]). This transport system belong to... | [
"GO:0005524",
"GO:0031460",
"GO:0016020"
] | [
"ATP binding",
"glycine betaine transport",
"membrane"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"NCBIFAM"
] | [
"TIGR01186"
] | [
"proV"
] | [
18365
] | 1 | [
"GP"
] | [
"GenProp1126"
] | [
"GP:GenProp1126"
] | 1 | [
"7ahc",
"7ahd",
"7ahe",
"7ahh"
] | 4 | [
"PUB00009832",
"PUB00019966",
"PUB00061606",
"PUB00061607",
"PUB00061608",
"PUB00061609",
"PUB00086656",
"PUB00106868",
"PUB00106869"
] | [
"10216873",
"11055912",
"7898450",
"19114512",
"10939245",
"16645306",
"16000740",
"12571024",
"23249124"
] | [
"Two evolutionarily closely related ABC transporters mediate the uptake of choline for synthesis of the osmoprotectant glycine betaine in Bacillus subtilis.",
"Identification and characterization of an ATP binding cassette L-carnitine transporter in Listeria monocytogenes.",
"The osmoprotectant proline betaine ... | [
1999,
2000,
1995,
2009,
2000,
2005,
2005,
2003,
2013
] | 9 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Methanobacteriota",
"unclassified sequences"
] | [
18045,
22,
144,
154
] | 4 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Glycine betaine/proline betaine transport system ATP-binding protein ProV-like | Glycine betaine/proline betaine transport system ATP-binding protein ProV-like | Gly-betaine_transp_ATP-bd | 6 |
IPR005893 | 5,893 | Spermidine/putrescine import ATP-binding protein PotA-like | PotA-like | Family | 21,593 | false | false | This entry represents the spermidine/putrescine ABC transporter ATP binding subunit in bacteria and its equivalents in archaea. This transport system belong to the larger ATP-Binding Cassette (ABC) transporter superfamily. Polyamines like spermidine and putrescine play vital role in cell proliferation, differentiation,... | [
"GO:0015417",
"GO:0015846",
"GO:0043190"
] | [
"ABC-type polyamine transporter activity",
"polyamine transport",
"ATP-binding cassette (ABC) transporter complex"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"NCBIFAM"
] | [
"TIGR01187"
] | [
"potA"
] | [
21593
] | 1 | [
"EC"
] | [
"7.6.2.11"
] | [
"EC:7.6.2.11"
] | 1 | [
"8y5f",
"8y5g",
"8y5h",
"8y5i",
"8zx1"
] | 5 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
93,
21166,
24,
310
] | 4 | [
"Escherichia coli (strain K12)"
] | [
2
] | 1 | true | Family | Spermidine/putrescine import ATP-binding protein PotA-like | Spermidine/putrescine import ATP-binding protein PotA-like | PotA-like | 5 |
IPR005894 | 5,894 | Daunorubicin resistance ABC transporter ATP-binding subunit DrrA | DrrA | Family | 17,836 | false | false | ABC transporters belong to the ATP-Binding Cassette (ABC) superfamily, which uses the hydrolysis of ATP to energise diverse biological systems. ABC transporters minimally consist of two conserved regions: a highly conserved ATP binding cassette (ABC) and a less conserved transmembrane domain (TMD). These can be found o... | [
"GO:0005524",
"GO:0043215",
"GO:1900753"
] | [
"ATP binding",
"daunorubicin transport",
"doxorubicin transport"
] | [
"molecular_function",
"biological_process",
"biological_process"
] | 3 | [
"NCBIFAM"
] | [
"TIGR01188"
] | [
"drrA"
] | [
17836
] | 1 | [
"EC",
"METACYC"
] | [
"7.6.2.2",
"PWY-6972"
] | [
"EC:7.6.2.2",
"METACYC:PWY-6972"
] | 2 | [
"4yer"
] | 1 | [
"PUB00062321",
"PUB00062322",
"PUB00158909"
] | [
"20158521",
"9006006",
"39375957"
] | [
"Daunorubicin efflux in Streptomyces peucetius modulates biosynthesis by feedback regulation.",
"Expression and characterization of DrrA and DrrB proteins of Streptomyces peucetius in Escherichia coli: DrrA is an ATP binding protein.",
"The involvement of multiple ABC transporters in daunorubicin efflux in Stre... | [
2010,
1997,
2024
] | 3 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
1027,
16558,
6,
245
] | 4 | [] | [] | 0 | true | Family | Daunorubicin resistance ABC transporter ATP-binding subunit DrrA | Daunorubicin resistance ABC transporter ATP-binding subunit DrrA | DrrA | 9 |
IPR005895 | 5,895 | ABC transporter, haem export, CcmA | ABC_transptr_haem_export_CcmA | Family | 11,501 | false | false | This family contains the cytochrome c biogenesis protein encoded by ccmA, part Ccm-System I found in bacteria, archaea and plant mitochondria. Bacterial c-type cytochromes are located on the periplasmic side of the cytoplasmic membrane. Several gene products encoded in a locus designated as Cytochrome c maturation (Ccm... | [
"GO:0022857",
"GO:0017004"
] | [
"transmembrane transporter activity",
"cytochrome complex assembly"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PANTHER",
"NCBIFAM"
] | [
"PTHR43499",
"TIGR01189"
] | [
"",
"ccmA"
] | [
10711,
10564
] | 2 | [
"EC",
"GP",
"PROSITEDOC"
] | [
"7.6.2.5",
"GenProp0678",
"PDOC51237"
] | [
"EC:7.6.2.5",
"GP:GenProp0678",
"PROSITEDOC:PDOC51237"
] | 3 | [
"7f02",
"7f03",
"7f04",
"7vfj",
"7vfp",
"8ce1",
"8ce5",
"8ce8",
"8cea"
] | 9 | [
"PUB00088326"
] | [
"24631867"
] | [
"Cytochrome c biogenesis System I: an intricate process catalyzed by a maturase supercomplex?"
] | [
2014
] | 1 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
24,
10604,
667,
206
] | 4 | [
"Arabidopsis thaliana",
"Escherichia coli (strain K12)",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
2,
1,
4,
12
] | 4 | true | Family | ABC transporter, haem export, CcmA | ABC transporter, haem export, CcmA | ABC_transptr_haem_export_CcmA | 5 |
IPR005896 | 5,896 | Glucan exporter ATP-binding protein, NdvA | NdvA | Family | 823 | false | false | The ATP-Binding Cassette (ABC) superfamily forms one of the largest of all protein families with a diversity of physiological functions [ ]. Several studies have shown that there is a correlation between the functional characterisation and the phylogenetic classification of the ABC cassette [ , ]. More than 50 subfamil... | [
"GO:0015441",
"GO:0015775",
"GO:0005886"
] | [
"ABC-type beta-glucan transporter activity",
"beta-glucan transport",
"plasma membrane"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"NCBIFAM"
] | [
"TIGR01192"
] | [
"chvA"
] | [
823
] | 1 | [
"EC"
] | [
"7.5.2.3"
] | [
"EC:7.5.2.3"
] | 1 | [
"7znu",
"7zo8",
"7zo9",
"7zoa"
] | 4 | [
"PUB00014769",
"PUB00017894",
"PUB00043654",
"PUB00060286"
] | [
"9873074",
"11421269",
"11421270",
"3042754"
] | [
"Getting in or out: early segregation between importers and exporters in the evolution of ATP-binding cassette (ABC) transporters.",
"ABC transporters: physiology, structure and mechanism--an overview.",
"The ABC of ABCS: a phylogenetic and functional classification of ABC systems in living organisms.",
"The ... | [
1999,
2001,
2001,
1988
] | 4 | [
"IPR039421"
] | [] | 1 | 0 | 1 | [
"Pseudomonadota",
"metagenomes"
] | [
821,
2
] | 2 | [] | [] | 0 | true | Family | Glucan exporter ATP-binding protein, NdvA | Glucan exporter ATP-binding protein, NdvA | NdvA | 8 |
IPR005897 | 5,897 | Peptidase C39, ABC-type bacteriocin transporter | Pept_C39_ABC_bacteriocin | Family | 1,650 | false | false | This family contains ABC-type bacteriocin transporter. In general, bacteriocins are agents which are responsible for killing or inhibiting the closely related species or even different strains of the same species. Bacteriocins are encoded by bacterial plasmids. Bacteriocins are named after the species and hence in lite... | [
"GO:0008234",
"GO:0043214",
"GO:0043213",
"GO:0016020"
] | [
"cysteine-type peptidase activity",
"ABC-type bacteriocin transporter activity",
"bacteriocin transport",
"membrane"
] | [
"molecular_function",
"molecular_function",
"biological_process",
"cellular_component"
] | 4 | [
"NCBIFAM"
] | [
"TIGR01193"
] | [
"bacteriocin_ABC"
] | [
1650
] | 1 | [
"EC"
] | [
"3.4.22.-"
] | [
"EC:3.4.22.-"
] | 1 | [
"4ry2",
"4s0f",
"6v9z",
"7t54",
"7t55",
"7t56",
"7t57",
"8hf4",
"8hf5",
"8hf6",
"8hf7",
"8k4b",
"8k7a",
"8vow",
"8vox",
"8voz",
"8vp1",
"8vp3",
"8vp5",
"8vp6",
"8vp8",
"8vp9",
"8vpa",
"8vpb",
"9azl",
"9baa"
] | 26 | [
"PUB00004290",
"PUB00014769",
"PUB00017894",
"PUB00017895",
"PUB00017896",
"PUB00017897",
"PUB00017898",
"PUB00017899",
"PUB00018400",
"PUB00025109",
"PUB00026406",
"PUB00033909",
"PUB00043654"
] | [
"9872322",
"9873074",
"11421269",
"1282354",
"9640644",
"11988180",
"11470432",
"11402022",
"7565085",
"11080142",
"11532960",
"16377622",
"11421270"
] | [
"Crystal structure of the ATP-binding subunit of an ABC transporter.",
"Getting in or out: early segregation between importers and exporters in the evolution of ATP-binding cassette (ABC) transporters.",
"ABC transporters: physiology, structure and mechanism--an overview.",
"ABC transporters: from microorgani... | [
1998,
1999,
2001,
1992,
1998,
2002,
2001,
2001,
1995,
2000,
2001,
2006,
2001
] | 13 | [
"IPR039421"
] | [] | 1 | 0 | 1 | [
"Bacteria",
"Candidatus Methanoplasma termitum",
"bioreactor metagenome"
] | [
1648,
1,
1
] | 3 | [] | [] | 0 | true | Family | Peptidase C39, ABC-type bacteriocin transporter | Peptidase C39, ABC-type bacteriocin transporter | Pept_C39_ABC_bacteriocin | 4 |
IPR005898 | 5,898 | Cyclic peptide transporter SyrD/Yoji-like | Cyc_pep_transpt_SyrD/YojI | Family | 4,762 | false | false | Bacteria have elaborate pathways for the production of toxins and secondary metabolites. Many such compounds, including syringomycin and pyoverdine are synthesized on non-ribosomal templates consisting of a multienzyme complex. On several occasions the proteins of the complex and transporter protein are present on the ... | [
"GO:0005524",
"GO:1904680",
"GO:0015833",
"GO:0016020"
] | [
"ATP binding",
"peptide transmembrane transporter activity",
"peptide transport",
"membrane"
] | [
"molecular_function",
"molecular_function",
"biological_process",
"cellular_component"
] | 4 | [
"NCBIFAM"
] | [
"TIGR01194"
] | [
"cyc_pep_trnsptr"
] | [
4762
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00004290",
"PUB00014769",
"PUB00017894",
"PUB00017895",
"PUB00017896",
"PUB00017897",
"PUB00017898",
"PUB00017899",
"PUB00025109",
"PUB00026406",
"PUB00043654",
"PUB00060277",
"PUB00060278",
"PUB00060279"
] | [
"9872322",
"9873074",
"11421269",
"1282354",
"9640644",
"11988180",
"11470432",
"11402022",
"11080142",
"11532960",
"11421270",
"8231810",
"15866933",
"15743962"
] | [
"Crystal structure of the ATP-binding subunit of an ABC transporter.",
"Getting in or out: early segregation between importers and exporters in the evolution of ATP-binding cassette (ABC) transporters.",
"ABC transporters: physiology, structure and mechanism--an overview.",
"ABC transporters: from microorgani... | [
1998,
1999,
2001,
1992,
1998,
2002,
2001,
2001,
2000,
2001,
2001,
1993,
2005,
2005
] | 14 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"marine sediment metagenome"
] | [
4754,
5,
3
] | 3 | [
"Arabidopsis thaliana",
"Escherichia coli (strain K12)"
] | [
1,
1
] | 2 | true | Family | Cyclic peptide transporter SyrD/Yoji-like | Cyclic peptide transporter SyrD/Yoji-like | Cyc_pep_transpt_SyrD/YojI | 4 |
IPR005899 | 5,899 | Sodium ion-translocating decarboxylase | Na_pump_deCOase | Family | 5,826 | false | false | This family comprises distantly related, low complexity, hydrophobic small subunits of several related sodium ion-pumping decarboxylases. These include oxaloacetate decarboxylase gamma subunit and methylmalonyl-CoA decarboxylase delta subunit [ , ]. | [
"GO:0015081",
"GO:0036376",
"GO:0016020"
] | [
"sodium ion transmembrane transporter activity",
"sodium ion export across plasma membrane",
"membrane"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PFAM",
"NCBIFAM"
] | [
"PF04277",
"TIGR01195"
] | [
"OAD_gamma",
"oadG_fam"
] | [
5825,
4036
] | 2 | [
"EC"
] | [
"7.2.4.2"
] | [
"EC:7.2.4.2"
] | 1 | [
"6iva",
"6iww"
] | 2 | [
"PUB00007893",
"PUB00010124"
] | [
"11248185",
"11802728"
] | [
"Sodium ion-translocating decarboxylases.",
"Subunit gamma of the oxaloacetate decarboxylase Na(+) pump: interaction with other subunits/domains of the complex and binding site for the Zn(2+) metal ion."
] | [
2001,
2002
] | 2 | [] | [
"IPR014497",
"IPR023424"
] | 0 | 2 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
62,
5626,
2,
136
] | 4 | [] | [] | 0 | true | Family | Sodium ion-translocating decarboxylase | Sodium ion-translocating decarboxylase | Na_pump_deCOase | 2 |
IPR005900 | 5,900 | 6-phosphogluconolactonase, DevB-type | 6-phosphogluconolactonase_DevB | Domain | 20,004 | false | false | This entry refers to the DevB type of 6-phosphogluconolactonase. 6-phosphogluconolactonases (6PGL) are cytosolic enzymes found in all organisms that catalyse the hydrolysis of 6-phosphogluconolactone to 6-phosphogluconic acid in the oxidative phase of the pentose phosphate pathway. Trypanosoma brucei and other characte... | [
"GO:0017057",
"GO:0005975",
"GO:0006098"
] | [
"6-phosphogluconolactonase activity",
"carbohydrate metabolic process",
"pentose-phosphate shunt"
] | [
"molecular_function",
"biological_process",
"biological_process"
] | 3 | [
"NCBIFAM",
"CDD"
] | [
"TIGR01198",
"cd01400"
] | [
"pgl",
"6PGL"
] | [
19687,
19718
] | 2 | [
"EC",
"GP",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"3.1.1.31",
"GenProp0120",
"PWY-8004",
"R-CEL-71336",
"R-DDI-71336",
"R-DME-71336",
"R-HSA-71336",
"R-MMU-71336",
"R-RNO-71336",
"R-SCE-71336",
"R-SPO-71336"
] | [
"EC:3.1.1.31",
"GP:GenProp0120",
"METACYC:PWY-8004",
"REACTOME:R-CEL-71336",
"REACTOME:R-DDI-71336",
"REACTOME:R-DME-71336",
"REACTOME:R-HSA-71336",
"REACTOME:R-MMU-71336",
"REACTOME:R-RNO-71336",
"REACTOME:R-SCE-71336",
"REACTOME:R-SPO-71336"
] | 11 | [
"1pbt",
"1vl1",
"1y89",
"2j0e",
"3ch7",
"3css",
"3e7f",
"3eb9",
"3ico",
"3lhi",
"3lwd",
"3nwp",
"3oc6",
"3tx2",
"4tm7",
"4tm8",
"6vye",
"8em2"
] | 18 | [
"PUB00017646",
"PUB00051612",
"PUB00053730",
"PUB00158686",
"PUB00160401",
"PUB00160402"
] | [
"10869070",
"19345229",
"15576773",
"25613812",
"1719698",
"35858355"
] | [
"The Pseudomonas aeruginosa devB/SOL homolog, pgl, is a member of the hex regulon and encodes 6-phosphogluconolactonase.",
"Insights into the enzymatic mechanism of 6-phosphogluconolactonase from Trypanosoma brucei using structural data and molecular dynamics simulation.",
"Identification of the Escherichia col... | [
2000,
2009,
2004,
2015,
1991,
2022
] | 6 | [
"IPR006148"
] | [] | 1 | 0 | 1 | [
"Bacteria",
"Candidatus Iainarchaeum sp.",
"Eukaryota",
"unclassified sequences"
] | [
12971,
2,
6834,
197
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
18,
1,
3,
1,
5,
9,
1,
7,
8,
4,
1,
15
] | 12 | true | Domain | 6-phosphogluconolactonase, DevB-type | 6-phosphogluconolactonase, DevB-type | 6-phosphogluconolactonase_DevB | 2 |
IPR005901 | 5,901 | GLPGLI family protein | GLPGLI | Family | 7,541 | false | false | This protein family was first noted as a paralogous set in Porphyromonas gingivalis, but it is more widely distributed among the Bacteroidetes. The protein family is now renamed GLPGLI after its best-conserved motif. | [] | [] | [] | 0 | [
"PFAM",
"NCBIFAM"
] | [
"PF09697",
"TIGR01200"
] | [
"Porph_ging",
"GLPGLI"
] | [
5717,
7533
] | 2 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
7503,
5,
33
] | 3 | [] | [] | 0 | true | Family | GLPGLI family protein | GLPGLI family protein | GLPGLI | 5 |
IPR005902 | 5,902 | Putative DNA-binding protein, HU-related | HU_DNA-bd_put | Family | 3,544 | false | false | This family of proteins is related to, but longer than, DNA-binding protein HU. It contains a distinctive domain architecture when compared to HU and related histone-like DNA-binding. Members include, so far, a protein from Bacteroides fragilis and ten from Porphyromonas gingivalis (Bacteroides gingivalis). Both specie... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"TIGR01201"
] | [
"HU_rel"
] | [
3544
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [
"IPR000119"
] | [] | 1 | 0 | 1 | [
"Bacteria",
"unclassified Caudoviricetes",
"unclassified sequences"
] | [
3492,
3,
49
] | 3 | [] | [] | 0 | true | Family | Putative DNA-binding protein, HU-related | Putative DNA-binding protein, HU-related | HU_DNA-bd_put | 6 |
IPR005903 | 5,903 | 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide a dehydrogenase | BchC | Family | 650 | false | false | Some prokaryotes, such as the purple and green sulphur bacteria, gain energy from a mode of photosynthesis that does not generate oxygen, and is inhibited by its presence [ , ]. These organisms do not include chlorophylls in their photosynthetic pigments, but instead use closely related molecules known as bacteriochlor... | [
"GO:0016491",
"GO:0036354",
"GO:0030494"
] | [
"oxidoreductase activity",
"bacteriochlorophyllide-a dehydrogenase activity",
"bacteriochlorophyll biosynthetic process"
] | [
"molecular_function",
"molecular_function",
"biological_process"
] | 3 | [
"NCBIFAM"
] | [
"TIGR01202"
] | [
"bchC"
] | [
650
] | 1 | [
"GP"
] | [
"GenProp0146"
] | [
"GP:GenProp0146"
] | 1 | [] | 0 | [
"PUB00003756",
"PUB00034690",
"PUB00034691",
"PUB00034692"
] | [
"8437569",
"7832589",
"9729607",
"9442890"
] | [
"Genetic analysis of the bchC and bchA genes of Rhodobacter sphaeroides.",
"Protein structure, electron transfer and evolution of prokaryotic photosynthetic reaction centers.",
"Aerobic anoxygenic phototrophic bacteria.",
"Genetic analysis of chlorophyll biosynthesis."
] | [
1993,
1994,
1998,
1997
] | 4 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Effrenium voratum",
"freshwater sediment metagenome"
] | [
648,
1,
1
] | 3 | [] | [] | 0 | true | Family | 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide a dehydrogenase | 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide a dehydrogenase | BchC | 7 |
IPR005904 | 5,904 | Hypoxanthine phosphoribosyl transferase | Hxn_phspho_trans | Family | 21,355 | false | false | Phosphoribosyltransferases (PRT) are enzymes that catalyze the synthesis of beta-n-5'-monophosphates from phosphoribosylpyrophosphate (PRPP) and an enzyme specific amine. A number of PRT's are involved in the biosynthesis of purine, pyrimidine, and pyridine nucleotides, or in the salvage of purines and pyrimidines. Pur... | [
"GO:0004422",
"GO:0006166"
] | [
"hypoxanthine phosphoribosyltransferase activity",
"purine ribonucleoside salvage"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"NCBIFAM"
] | [
"TIGR01203"
] | [
"HGPRTase"
] | [
21355
] | 1 | [
"EC",
"GP",
"GP",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"2.4.2.8",
"GenProp1235",
"GenProp1528",
"PWY-6599",
"PWY-6609",
"PWY-6610",
"PWY-6620",
"R-BTA-74217",
"R-BTA-9748787",
"R-DDI-74217",
"R-DDI-9748787",
"R-HSA-74217",
"R-HSA-9734281",
"R-HSA-9748787",
"R-MMU-74217",
"R-MMU-9748787",
"R-RNO-74217",
"R-RNO-9748787",
"R-SSC-74217",... | [
"EC:2.4.2.8",
"GP:GenProp1235",
"GP:GenProp1528",
"METACYC:PWY-6599",
"METACYC:PWY-6609",
"METACYC:PWY-6610",
"METACYC:PWY-6620",
"REACTOME:R-BTA-74217",
"REACTOME:R-BTA-9748787",
"REACTOME:R-DDI-74217",
"REACTOME:R-DDI-9748787",
"REACTOME:R-HSA-74217",
"REACTOME:R-HSA-9734281",
"REACTOME:... | 20 | [
"1bzy",
"1cjb",
"1d6n",
"1dbr",
"1fsg",
"1g9s",
"1g9t",
"1grv",
"1hgx",
"1hmp",
"1i0i",
"1i0l",
"1i13",
"1i14",
"1j7j",
"1p17",
"1p18",
"1p19",
"1pzm",
"1qk3",
"1qk4",
"1qk5",
"1r3u",
"1tc1",
"1tc2",
"1yfz",
"1z7g",
"2geb",
"2jbh",
"2vfa",
"3acb",
"3acc"... | 102 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Methanobacteriati",
"unclassified Klosneuvirinae",
"unclassified sequences"
] | [
17188,
3826,
17,
3,
321
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
5,
1,
4,
1,
4,
2,
1,
11,
3
] | 9 | true | Family | Hypoxanthine phosphoribosyl transferase | Hypoxanthine phosphoribosyl transferase | Hxn_phspho_trans | 3 |
IPR005905 | 5,905 | D-alanine--D-alanine ligase | D_ala_D_ala | Family | 31,590 | false | false | D-alanine--D-alanine ligase ( ) is a bacterial enzyme involved in cell-wall biosynthesis. It participates in forming UDP-N-acetylmuramoyl pentapeptide, the peptidoglycan precursor. These enzymes are proteins of 300 to 360 amino acids containing many conserved regions. The N-terminal Gly-rich region could be involved in... | [
"GO:0005524",
"GO:0008716",
"GO:0005737"
] | [
"ATP binding",
"D-alanine-D-alanine ligase activity",
"cytoplasm"
] | [
"molecular_function",
"molecular_function",
"cellular_component"
] | 3 | [
"HAMAP",
"PIRSF",
"NCBIFAM"
] | [
"MF_00047",
"PIRSF039102",
"TIGR01205"
] | [
"Dala_Dala_lig",
"Ddl/VanB",
"D_ala_D_alaTIGR"
] | [
31190,
30665,
29106
] | 3 | [
"EC",
"GP",
"METACYC",
"METACYC",
"METACYC"
] | [
"6.3.2.4",
"GenProp1448",
"PWY-6386",
"PWY-6387",
"PWY-7953"
] | [
"EC:6.3.2.4",
"GP:GenProp1448",
"METACYC:PWY-6386",
"METACYC:PWY-6387",
"METACYC:PWY-7953"
] | 5 | [
"1e4e",
"1ehi",
"1iov",
"1iow",
"2dln",
"2fb9",
"2i80",
"2i87",
"2i8c",
"2pvp",
"2yzg",
"2yzm",
"2yzn",
"2zdg",
"2zdh",
"2zdq",
"3e5n",
"3i12",
"3k3p",
"3lwb",
"3n8d",
"3q1k",
"3r23",
"3r5f",
"3r5x",
"3rfc",
"3se7",
"3tqt",
"3v4z",
"4c5a",
"4c5b",
"4c5c"... | 66 | [] | [] | [] | [] | 0 | [] | [
"IPR058165",
"IPR058167"
] | 0 | 2 | 0 | [
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
30975,
68,
547
] | 3 | [
"Escherichia coli (strain K12)",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)"
] | [
2,
1
] | 2 | true | Family | D-alanine--D-alanine ligase | D-alanine--D-alanine ligase | D_ala_D_ala | 7 |
IPR005906 | 5,906 | Lysine biosynthesis protein LysW | LysW | Family | 1,338 | false | false | While most bacteria synthesise lysine via diaminopimelate, a few species, such as Thermus thermophilus, and some hyperthermophilic archaea, synthesise this amino acid from alpha-aminoadipate (AAA). LysW plays an essential role in this pathway by preventing unstable intermediates from undergoing intramolecular cyclisati... | [] | [] | [] | 0 | [
"NCBIFAM",
"PFAM",
"PANTHER",
"NCBIFAM",
"CDD"
] | [
"NF041070",
"PF21344",
"PTHR40393",
"TIGR01206",
"cd13946"
] | [
"carrier_LysW_Arch",
"Zn_ribbon_LysW",
"",
"lysW",
"LysW"
] | [
223,
1334,
953,
607,
311
] | 5 | [] | [] | [] | 0 | [
"3vpb",
"3wwl",
"3wwn",
"5ein",
"5eio",
"5k2m"
] | 6 | [
"PUB00053254"
] | [
"19620981"
] | [
"Discovery of proteinaceous N-modification in lysine biosynthesis of Thermus thermophilus."
] | [
2009
] | 1 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"unclassified sequences"
] | [
582,
730,
26
] | 3 | [] | [] | 0 | true | Family | Lysine biosynthesis protein LysW | Lysine biosynthesis protein LysW | LysW | 8 |
IPR005907 | 5,907 | Glucose-1-phosphate thymidylyltransferase, short form | G1P_thy_trans_s | Family | 23,599 | false | false | This group of proteins comprises a tightly conserved but broadly distributed subfamily (here designated as short form) of known and putative bacterial glucose-1-phosphate thymidylyltransferases ( , also known as dTDP-D-glucose synthase). It is well characterised in several species as the first of four enzymes involved ... | [
"GO:0008879"
] | [
"glucose-1-phosphate thymidylyltransferase activity"
] | [
"molecular_function"
] | 1 | [
"PANTHER",
"NCBIFAM",
"CDD"
] | [
"PTHR43532",
"TIGR01207",
"cd02538"
] | [
"",
"rmlA",
"G1P_TT_short"
] | [
23597,
20521,
20376
] | 3 | [
"EC",
"GP",
"GP",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC"
] | [
"2.7.7.24",
"GenProp0950",
"GenProp1403",
"PWY-6808",
"PWY-6942",
"PWY-6953",
"PWY-6973",
"PWY-6974",
"PWY-6976",
"PWY-7104",
"PWY-7301",
"PWY-7312",
"PWY-7315",
"PWY-7316",
"PWY-7318",
"PWY-7413",
"PWY-7414",
"PWY-7440",
"PWY-7657",
"PWY-7688",
"PWY-7814",
"PWY-8380"
] | [
"EC:2.7.7.24",
"GP:GenProp0950",
"GP:GenProp1403",
"METACYC:PWY-6808",
"METACYC:PWY-6942",
"METACYC:PWY-6953",
"METACYC:PWY-6973",
"METACYC:PWY-6974",
"METACYC:PWY-6976",
"METACYC:PWY-7104",
"METACYC:PWY-7301",
"METACYC:PWY-7312",
"METACYC:PWY-7315",
"METACYC:PWY-7316",
"METACYC:PWY-7318... | 22 | [
"1fxo",
"1fzw",
"1g0r",
"1g1l",
"1g23",
"1g2v",
"1g3l",
"1h5r",
"1h5s",
"1h5t",
"1iim",
"1iin",
"1lvw",
"1mc3",
"1mp3",
"1mp4",
"1mp5",
"3hl3",
"3pkp",
"3pkq",
"3zlk",
"3zll",
"4arw",
"4asj",
"4asy",
"4b2w",
"4b2x",
"4b3u",
"4b42",
"4b4b",
"4b4g",
"4b4m"... | 58 | [
"PUB00021622",
"PUB00025526",
"PUB00026041",
"PUB00028942",
"PUB00080745"
] | [
"11118200",
"11697907",
"11373625",
"12171937",
"12773151"
] | [
"The structural basis of the catalytic mechanism and regulation of glucose-1-phosphate thymidylyltransferase (RmlA).",
"Kinetic and crystallographic analyses support a sequential-ordered bi bi catalytic mechanism for Escherichia coli glucose-1-phosphate thymidylyltransferase.",
"Structure, mechanism and enginee... | [
2000,
2001,
2001,
2002,
2003
] | 5 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Caudoviricetes",
"Eukaryota",
"unclassified sequences"
] | [
190,
22865,
24,
62,
458
] | 5 | [
"Escherichia coli (strain K12)"
] | [
2
] | 1 | true | Family | Glucose-1-phosphate thymidylyltransferase, short form | Glucose-1-phosphate thymidylyltransferase, short form | G1P_thy_trans_s | 3 |
IPR005908 | 5,908 | Glucose-1-phosphate thymidylyltransferase, long form | G1P_thy_trans_l | Family | 2,406 | false | false | This family is the long form of Glucose-1-phosphate thymidylyltransferase. Glucose-1-phosphate thymidylyltransferase catalyses the formation of dTDP-glucose, from dTTP and glucose 1-phosphate. It is the first enzyme in the biosynthesis of dTDP-L-rhamnose, a cell wall constituent and a feedback inhibitor of the enzyme [... | [] | [] | [] | 0 | [
"NCBIFAM",
"CDD"
] | [
"TIGR01208",
"cd04189"
] | [
"rmlA_long",
"G1P_TT_long"
] | [
2287,
2319
] | 2 | [
"GP"
] | [
"GenProp0950"
] | [
"GP:GenProp0950"
] | 1 | [] | 0 | [
"PUB00021622",
"PUB00025526",
"PUB00026041",
"PUB00028942",
"PUB00080745"
] | [
"11118200",
"11697907",
"11373625",
"12171937",
"12773151"
] | [
"The structural basis of the catalytic mechanism and regulation of glucose-1-phosphate thymidylyltransferase (RmlA).",
"Kinetic and crystallographic analyses support a sequential-ordered bi bi catalytic mechanism for Escherichia coli glucose-1-phosphate thymidylyltransferase.",
"Structure, mechanism and enginee... | [
2000,
2001,
2001,
2002,
2003
] | 5 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Exaiptasia diaphana",
"unclassified sequences"
] | [
270,
2060,
1,
75
] | 4 | [] | [] | 0 | true | Family | Glucose-1-phosphate thymidylyltransferase, long form | Glucose-1-phosphate thymidylyltransferase, long form | G1P_thy_trans_l | 7 |
IPR005909 | 5,909 | Archaeosine synthase subunit beta | RaSEA | Family | 836 | false | false | This is a family of archaeal radical SAM enzymes (RaSEA) which are involved in the synthesis of archaeosine, a modified nucleoside present in the dihydrouridine loop (D-loop) of archaeal tRNAs. RaSEA forms a robust complex with archaeosine synthase (ArcS) to catalyse the cleavage of the C(epsilon)-N bond of the lysine ... | [] | [] | [] | 0 | [
"PIRSF",
"NCBIFAM"
] | [
"PIRSF004954",
"TIGR01210"
] | [
"Radical_SAM",
""
] | [
810,
712
] | 2 | [] | [] | [] | 0 | [] | 0 | [
"PUB00094213"
] | [
"31740832"
] | [
"Identification of a radical SAM enzyme involved in the synthesis of archaeosine."
] | [
2019
] | 1 | [
"IPR039661"
] | [] | 1 | 0 | 1 | [
"Archaea",
"Bacteria",
"ecological metagenomes"
] | [
685,
126,
25
] | 3 | [] | [] | 0 | true | Family | Archaeosine synthase subunit beta | Archaeosine synthase subunit beta | RaSEA | 4 |
IPR005911 | 5,911 | Protein YhcC-like | YhcC-like | Family | 7,726 | false | false | This family of radical-SAM enzymes incudes Protein YhcC from Escherichia coli, which can cleave S-adenosyl-L-methionine into methionine and 5'-deoxyadenosine (AdoH) in vitro [ ]. | [
"GO:0051536"
] | [
"iron-sulfur cluster binding"
] | [
"molecular_function"
] | 1 | [
"SFLD",
"NCBIFAM"
] | [
"SFLDG01091",
"TIGR01212"
] | [
"uncharacterized_CHP01210-like",
""
] | [
7645,
7692
] | 2 | [] | [] | [] | 0 | [] | 0 | [
"PUB00078324"
] | [
"25117543"
] | [
"An integrative computational model for large-scale identification of metalloproteins in microbial genomes: a focus on iron-sulfur cluster proteins."
] | [
2014
] | 1 | [
"IPR039661"
] | [] | 1 | 0 | 1 | [
"Archaea",
"Bacteria",
"Eukaryota",
"Siphoviridae sp. ctBLh2",
"metagenomes"
] | [
38,
7591,
2,
1,
94
] | 5 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Protein YhcC-like | Protein YhcC-like | YhcC-like | 6 |
IPR005912 | 5,912 | tRNA pseudouridine synthase, Pus10 | Pus10 | Family | 731 | false | false | This entry represents the Pus 10 family of tRNA pseudouridine synthases. Family members are responsible for the synthesis of pseudouridine from uracil-54 and uracil-55 in the psi GC loop of transfer RNAs [ ]. The family appears to be distinct from the five commonly identified families of Psi synthases [ ]. These protei... | [
"GO:0000049",
"GO:0009982",
"GO:0001522",
"GO:0006400"
] | [
"tRNA binding",
"pseudouridine synthase activity",
"pseudouridine synthesis",
"tRNA modification"
] | [
"molecular_function",
"molecular_function",
"biological_process",
"biological_process"
] | 4 | [
"HAMAP"
] | [
"MF_01893"
] | [
"Pus10_arch"
] | [
731
] | 1 | [
"EC"
] | [
"5.4.99.25"
] | [
"EC:5.4.99.25"
] | 1 | [] | 0 | [
"PUB00056793"
] | [
"18952823"
] | [
"Archaeal Pus10 proteins can produce both pseudouridine 54 and 55 in tRNA."
] | [
2008
] | 1 | [
"IPR039894"
] | [] | 1 | 0 | 1 | [
"Archaea",
"Candidatus Bipolaricaulota",
"ecological metagenomes"
] | [
723,
3,
5
] | 3 | [] | [] | 0 | true | Family | tRNA pseudouridine synthase, Pus10 | tRNA pseudouridine synthase, Pus10 | Pus10 | 4 |
IPR005913 | 5,913 | dTDP-4-dehydrorhamnose reductase | RmlD | Family | 31,434 | false | false | dTDP-4-dehydrorhamnose reductase or RmlD ( ) catalyses the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose, which is the final step in the conversion of dTDP-D-glucose to dTDP-L-rhamnose [ ]. dTDP-rhamnose is essential for growth of mycobacteria [ ]. dTDP-L-rhamnose is the precursor of L-Rhamnose (... | [] | [] | [] | 0 | [
"PANTHER",
"NCBIFAM"
] | [
"PTHR10491",
"TIGR01214"
] | [
"",
"rmlD"
] | [
31408,
18312
] | 2 | [
"EC",
"GP",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"1.1.1",
"GenProp0183",
"R-BTA-156581",
"R-BTA-5689880",
"R-DRE-156581",
"R-DRE-5689880",
"R-HSA-156581",
"R-HSA-5689880",
"R-MMU-156581",
"R-MMU-5689880",
"R-RNO-156581",
"R-RNO-5689880",
"R-XTR-156581",
"R-XTR-5689880"
] | [
"EC:1.1.1",
"GP:GenProp0183",
"REACTOME:R-BTA-156581",
"REACTOME:R-BTA-5689880",
"REACTOME:R-DRE-156581",
"REACTOME:R-DRE-5689880",
"REACTOME:R-HSA-156581",
"REACTOME:R-HSA-5689880",
"REACTOME:R-MMU-156581",
"REACTOME:R-MMU-5689880",
"REACTOME:R-RNO-156581",
"REACTOME:R-RNO-5689880",
"REACTO... | 14 | [
"1kbz",
"1kc1",
"1kc3",
"1n2s",
"1vl0",
"2ydx",
"2ydy",
"3sc6",
"4ktt",
"4ktv",
"4ndn",
"4qqr",
"4wpg",
"5u9c",
"7jid",
"8ctr",
"8g22",
"9g4o"
] | 18 | [
"PUB00071248",
"PUB00071249",
"PUB00071250",
"PUB00071251",
"PUB00089648"
] | [
"21640586",
"12029057",
"11065359",
"10644686",
"10770761"
] | [
"A new route to dTDP-6-deoxy-l-talose and dTDP-L-rhamnose: dTDP-L-rhamnose 4-epimerase in Burkholderia thailandensis.",
"Formation of dTDP-rhamnose is essential for growth of mycobacteria.",
"Involvement of the rml locus in core oligosaccharide and O polysaccharide assembly in Pseudomonas aeruginosa.",
"Cloni... | [
2011,
2002,
2000,
2000,
2000
] | 5 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
405,
25683,
4627,
69,
650
] | 5 | [
"Arabidopsis thaliana",
"Danio rerio",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
4,
6,
1,
14,
2,
2,
2,
7,
5
] | 9 | true | Family | dTDP-4-dehydrorhamnose reductase | dTDP-4-dehydrorhamnose reductase | RmlD | 5 |
IPR005914 | 5,914 | Acetoacetyl-CoA synthase | Acac_CoA_synth | Family | 11,771 | false | false | Isoprenoids are a large class of compounds, with more than 20,000 structures currently known, which are found in all living organisms. Some play essential physiological roles, such as sterols that stabilise cell membranes or carotenoids involved in photosynthesis, while the function of many others is not well understoo... | [
"GO:0030729",
"GO:0006629"
] | [
"acetoacetate-CoA ligase activity",
"lipid metabolic process"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"NCBIFAM"
] | [
"TIGR01217"
] | [
"ac_ac_CoA_syn"
] | [
11771
] | 1 | [
"EC",
"GP",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"6.2.1.16",
"GenProp0047",
"PWY-8058",
"R-CEL-77111",
"R-DRE-77111",
"R-HSA-77111",
"R-MMU-77111",
"R-RNO-77111",
"R-XTR-77111"
] | [
"EC:6.2.1.16",
"GP:GenProp0047",
"METACYC:PWY-8058",
"REACTOME:R-CEL-77111",
"REACTOME:R-DRE-77111",
"REACTOME:R-HSA-77111",
"REACTOME:R-MMU-77111",
"REACTOME:R-RNO-77111",
"REACTOME:R-XTR-77111"
] | 9 | [
"4wd1"
] | 1 | [
"PUB00034687",
"PUB00034688",
"PUB00034689",
"PUB00080716"
] | [
"15604784",
"8240251",
"10735852",
"20534346"
] | [
"Production of mevalonate by a metabolically-engineered Escherichia coli.",
"Isoprenoid biosynthesis in bacteria: a novel pathway for the early steps leading to isopentenyl diphosphate.",
"Requirement for the enzymes acetoacetyl coenzyme A synthetase and poly-3-hydroxybutyrate (PHB) synthase for growth of Sinor... | [
2004,
1993,
2000,
2010
] | 4 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
41,
7459,
4129,
142
] | 4 | [
"Caenorhabditis elegans",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus"
] | [
1,
2,
2,
1,
2,
6
] | 6 | true | Family | Acetoacetyl-CoA synthase | Acetoacetyl-CoA synthase | Acac_CoA_synth | 5 |
IPR005915 | 5,915 | Tandem five-TM protein | Tandem_5TM | Family | 812 | false | false | Members of this family of proteins, with average length of 210, have no invariant residues but five predicted transmembrane segments. Strangely, most members occur in groups of consecutive paralogous genes. A striking example is a set of eleven encoded consecutively, head-to-tail, in Staphylococcus aureus strain COL. | [] | [] | [] | 0 | [
"PFAM",
"NCBIFAM"
] | [
"PF04276",
"TIGR01218"
] | [
"DUF443",
"Gpos_tandem_5TM"
] | [
668,
791
] | 2 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"human gut metagenome"
] | [
811,
1
] | 2 | [] | [] | 0 | true | Family | Tandem five-TM protein | Tandem five-TM protein | Tandem_5TM | 6 |
IPR005917 | 5,917 | Phosphomevalonate kinase, bacteria | Pmev_kinase_bact | Family | 2,213 | false | false | This entry represents a group of predicted phosphomevalonate kinases from bacteria. | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"TIGR01220"
] | [
"Pmev_kin_Gr_pos"
] | [
2213
] | 1 | [
"GP"
] | [
"GenProp0047"
] | [
"GP:GenProp0047"
] | 1 | [
"1k47",
"3gon",
"3k17"
] | 3 | [
"PUB00003676",
"PUB00007911",
"PUB00015644",
"PUB00015669",
"PUB00015675",
"PUB00015730",
"PUB00015827",
"PUB00015835"
] | [
"1846667",
"11243736",
"11188689",
"12771135",
"8382990",
"12001237",
"8663599",
"12796487"
] | [
"Cloning and characterization of ERG8, an essential gene of Saccharomyces cerevisiae that encodes phosphomevalonate kinase.",
"Nonorthologous gene displacement of phosphomevalonate kinase.",
"Structure and mechanism of homoserine kinase: prototype for the GHMP kinase superfamily.",
"Crystal structure of 4-(cy... | [
1991,
2001,
2000,
2003,
1993,
2002,
1996,
2003
] | 8 | [
"IPR035102"
] | [] | 1 | 0 | 1 | [
"Bacteria",
"Candidatus Iainarchaeum sp.",
"metagenomes"
] | [
2201,
9,
3
] | 3 | [] | [] | 0 | true | Family | Phosphomevalonate kinase, bacteria | Phosphomevalonate kinase, bacteria | Pmev_kinase_bact | 9 |
IPR005918 | 5,918 | Conantokin, conserved site | Conantokin_CS | Conserved_site | 26 | false | false | The conantokins are a family of neuroactive peptides found in the venoms of fish-hunting cone snails. They possess a relatively high number of residues (4-5) of the non-standard amino acid gamma-carboxyglutamic acid (Gla), which is generated by the post-translational modification of glutamate (Glu) residues. Conantokin... | [
"GO:0035792"
] | [
"host cell postsynaptic membrane"
] | [
"cellular_component"
] | 1 | [
"PFAM",
"PROSITE"
] | [
"PF10550",
"PS60025"
] | [
"Toxin_36",
"CONANTOKIN"
] | [
9,
24
] | 2 | [
"PROSITEDOC"
] | [
"PDOC60025"
] | [
"PROSITEDOC:PDOC60025"
] | 1 | [
"1ad7",
"1awy",
"1ont",
"1onu",
"2dpq",
"2dpr",
"2myz",
"2mzk",
"2mzl",
"2mzm",
"5tbg",
"5tbq"
] | 12 | [
"PUB00002612",
"PUB00028201",
"PUB00033822",
"PUB00033823",
"PUB00033824",
"PUB00094357",
"PUB00094358",
"PUB00094359",
"PUB00094360"
] | [
"2180939",
"9398296",
"11554555",
"11096077",
"12350383",
"17962189",
"19309162",
"18586049",
"10604979"
] | [
"Conantokin-T. A gamma-carboxyglutamate containing peptide with N-methyl-d-aspartate antagonist activity.",
"Role of gamma-carboxyglutamic acid in the calcium-induced structural transition of conantokin G, a conotoxin from the marine snail Conus geographus.",
"Structure-function relationships of the NMDA recept... | [
1990,
1997,
2001,
2001,
2002,
2007,
2009,
2008,
2000
] | 9 | [] | [] | 0 | 0 | null | [
"Bilateria"
] | [
26
] | 1 | [] | [] | 0 | true | Conserved_site | Conantokin, conserved site | Conantokin, conserved site | Conantokin_CS | 7 |
IPR005919 | 5,919 | Higher eukaryotic phosphomevalonate kinase | Pmev_kin_anim | Family | 2,316 | false | false | Phosphomevalonate kinase ( ) catalyses the phosphorylation of 5-phosphomevalonate into 5-diphosphomevalonate, an essential step in isoprenoid biosynthesis via the mevalonate pathway. In an example of non orthologous gene displacement, two different types of phosphomevalonate kinase are found -the higher eukaryotic form... | [
"GO:0004631",
"GO:0006695",
"GO:0005737"
] | [
"phosphomevalonate kinase activity",
"cholesterol biosynthetic process",
"cytoplasm"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PFAM",
"PIRSF",
"PANTHER",
"NCBIFAM"
] | [
"PF04275",
"PIRSF036639",
"PTHR13101",
"TIGR01223"
] | [
"P-mevalo_kinase",
"PMK_anim",
"",
"Pmev_kin_anim"
] | [
2259,
848,
1590,
997
] | 4 | [
"EC",
"GP",
"GP",
"METACYC",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"2.7.4.2",
"GenProp0047",
"GenProp1432",
"PWY-7391",
"PWY-922",
"R-DME-191273",
"R-HSA-191273",
"R-HSA-2426168",
"R-MMU-191273",
"R-SSC-191273"
] | [
"EC:2.7.4.2",
"GP:GenProp0047",
"GP:GenProp1432",
"METACYC:PWY-7391",
"METACYC:PWY-922",
"REACTOME:R-DME-191273",
"REACTOME:R-HSA-191273",
"REACTOME:R-HSA-2426168",
"REACTOME:R-MMU-191273",
"REACTOME:R-SSC-191273"
] | 10 | [
"3ch4",
"7xnd"
] | 2 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Viruses",
"metagenomes"
] | [
34,
2270,
8,
4
] | 4 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
1,
1,
2,
3,
7
] | 6 | true | Family | Higher eukaryotic phosphomevalonate kinase | Higher eukaryotic phosphomevalonate kinase | Pmev_kin_anim | 5 |
IPR005920 | 5,920 | Imidazolonepropionase | HutI | Family | 16,599 | false | false | Imidazolonepropionase catalyses the third step in histidine degradation. It hydrolyses the carbon-nitrogen bonds in 4-imidazolone-5-propionic acid to yield N-formimino-l-glutamic acid [ ]. The enzyme contains two domains, a TIM (triose-phosphate isomerase) barrel domain with two insertions and a small β-sandwich domain... | [
"GO:0016812",
"GO:0019556",
"GO:0005737"
] | [
"hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides",
"L-histidine catabolic process to glutamate and formamide",
"cytoplasm"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"HAMAP",
"PANTHER",
"NCBIFAM",
"CDD"
] | [
"MF_00372",
"PTHR42752",
"TIGR01224",
"cd01296"
] | [
"HutI",
"",
"hutI",
"Imidazolone-5PH"
] | [
13506,
16589,
15738,
9967
] | 4 | [
"EC",
"GP",
"METACYC",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"3.5.2.7",
"GenProp1619",
"PWY-5028",
"PWY-5030",
"R-BTA-70921",
"R-CEL-70921",
"R-DDI-70921",
"R-DRE-70921",
"R-HSA-70921",
"R-MMU-70921",
"R-XTR-70921"
] | [
"EC:3.5.2.7",
"GP:GenProp1619",
"METACYC:PWY-5028",
"METACYC:PWY-5030",
"REACTOME:R-BTA-70921",
"REACTOME:R-CEL-70921",
"REACTOME:R-DDI-70921",
"REACTOME:R-DRE-70921",
"REACTOME:R-HSA-70921",
"REACTOME:R-MMU-70921",
"REACTOME:R-XTR-70921"
] | 11 | [
"2bb0",
"2g3f",
"2gok",
"2oof",
"2puz",
"2q09"
] | 6 | [
"PUB00013521",
"PUB00043335",
"PUB00043336"
] | [
"2842309",
"16990261",
"16198643"
] | [
"Organization and multiple regulation of histidine utilization genes in Pseudomonas putida.",
"A catalytic mechanism revealed by the crystal structures of the imidazolonepropionase from Bacillus subtilis.",
"Protein preparation, crystallization and preliminary X-ray analysis of imidazolonepropionase from Bacill... | [
1988,
2006,
2006
] | 3 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
230,
14563,
1527,
279
] | 4 | [
"Caenorhabditis elegans",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
1,
2,
1,
3
] | 5 | true | Family | Imidazolonepropionase | Imidazolonepropionase | HutI | 8 |
IPR005921 | 5,921 | Histidine ammonia-lyase | HutH | Family | 15,713 | false | false | Histidine ammonia-lyase deaminates histidine to urocanic acid, the first step in histidine degradation. It is closely related to the plant enzyme phenylalanine ammonia-lyase [ ] but is absent in plants and viruses. This enzyme contains a unique cofactor called 4-methylidene-imidazole-5-one group (MIO), which is produce... | [
"GO:0004397",
"GO:0006548",
"GO:0005737"
] | [
"histidine ammonia-lyase activity",
"L-histidine catabolic process",
"cytoplasm"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"HAMAP",
"NCBIFAM"
] | [
"MF_00229",
"TIGR01225"
] | [
"His_ammonia_lyase",
"hutH"
] | [
9338,
15708
] | 2 | [
"EC",
"GP",
"METACYC",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"4.3.1.3",
"GenProp1619",
"PWY-5028",
"PWY-5030",
"R-BTA-70921",
"R-CEL-70921",
"R-DDI-70921",
"R-HSA-70921",
"R-MMU-70921",
"R-RNO-70921"
] | [
"EC:4.3.1.3",
"GP:GenProp1619",
"METACYC:PWY-5028",
"METACYC:PWY-5030",
"REACTOME:R-BTA-70921",
"REACTOME:R-CEL-70921",
"REACTOME:R-DDI-70921",
"REACTOME:R-HSA-70921",
"REACTOME:R-MMU-70921",
"REACTOME:R-RNO-70921"
] | 10 | [
"1b8f",
"1eb4",
"1gk2",
"1gk3",
"1gkj",
"1gkm",
"6v6h",
"7tqr"
] | 8 | [
"PUB00021475",
"PUB00023551"
] | [
"11796111",
"10220322"
] | [
"Autocatalytic peptide cyclization during chain folding of histidine ammonia-lyase.",
"Crystal structure of histidine ammonia-lyase revealing a novel polypeptide modification as the catalytic electrophile."
] | [
2002,
1999
] | 2 | [
"IPR001106"
] | [] | 1 | 0 | 1 | [
"Archaea",
"Bacteria",
"Eukaryota",
"Mimiviridae",
"unclassified sequences"
] | [
199,
14021,
1337,
2,
154
] | 5 | [
"Caenorhabditis elegans",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
7,
1,
3,
2
] | 5 | true | Family | Histidine ammonia-lyase | Histidine ammonia-lyase | HutH | 3 |
IPR005922 | 5,922 | Phenylalanine ammonia-lyase | Phe_NH3-lyase | Family | 5,508 | false | false | This entry represents phenylalanine ammonia-lyase proteins. The ubiquitous higher plant enzyme phenylalanine ammonia-lyase (PAL; ) is a key biosynthetic catalyst in phenylpropanoid assembly. PAL catalyses the non-oxidative deamination of L-phenylalanine to trans-cinnamic acid. PAL contains a catalytic Ala-Ser-Gly triad... | [
"GO:0016841",
"GO:0006559",
"GO:0005737"
] | [
"ammonia-lyase activity",
"L-phenylalanine catabolic process",
"cytoplasm"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"NCBIFAM"
] | [
"TIGR01226"
] | [
"phe_am_lyase"
] | [
5508
] | 1 | [
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC"
] | [
"4.3.1.24",
"PWY-1121",
"PWY-5048",
"PWY-5883",
"PWY-6444",
"PWY-6457",
"PWY-8157"
] | [
"EC:4.3.1.24",
"METACYC:PWY-1121",
"METACYC:PWY-5048",
"METACYC:PWY-5883",
"METACYC:PWY-6444",
"METACYC:PWY-6457",
"METACYC:PWY-8157"
] | 7 | [
"1t6j",
"1t6p",
"1w27",
"1y2m",
"2yii",
"3nz4",
"4baa",
"4bab",
"4c5r",
"4c5s",
"4c5u",
"4c6g",
"4cq5",
"4v2q",
"4v2r",
"6at7",
"6f6t",
"6h2o",
"6hqf",
"6rgs"
] | 20 | [
"PUB00031359",
"PUB00035855",
"PUB00097889",
"PUB00097890"
] | [
"15350127",
"16478474",
"28605916",
"33242032"
] | [
"Crystal structure of phenylalanine ammonia lyase: multiple helix dipoles implicated in catalysis.",
"The essential tyrosine-containing loop conformation and the role of the C-terminal multi-helix region in eukaryotic phenylalanine ammonia-lyases.",
"Identification and Heterologous Production of a Benzoyl-Prime... | [
2004,
2006,
2017,
2021
] | 4 | [
"IPR001106"
] | [
"IPR031008"
] | 1 | 1 | 0 | [
"Eukaryota"
] | [
5508
] | 1 | [
"Arabidopsis thaliana",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
14,
1,
24,
41
] | 4 | true | Family | Phenylalanine ammonia-lyase | Phenylalanine ammonia-lyase | Phe_NH3-lyase | 5 |
IPR005923 | 5,923 | Formiminoglutamase | HutG | Family | 4,827 | false | false | Formiminoglutamase ( ), the fourth enzyme of histidine degradation, is similar to arginases and agmatinases [ ]. It is often encoded near other enzymes of the histidine degredation pathway: histidine ammonia-lyase, urocanate hydratase, and imidazolonepropionase. It catalyses the reaction: N-formimidoyl-L-glutamate + H2... | [
"GO:0050415",
"GO:0019556"
] | [
"formimidoylglutamase activity",
"L-histidine catabolic process to glutamate and formamide"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"HAMAP",
"NCBIFAM"
] | [
"MF_00737",
"TIGR01227"
] | [
"Formimidoylglutam",
"hutG"
] | [
4181,
4767
] | 2 | [
"EC",
"GP"
] | [
"3.5.3.8",
"GenProp1619"
] | [
"EC:3.5.3.8",
"GP:GenProp1619"
] | 2 | [
"1xfk",
"3m1r"
] | 2 | [
"PUB00070322"
] | [
"4990470"
] | [
"Urocanase and N-formimino-L-glutamate formiminohydrolase of Bacillus subtilis, two enzymes of the histidine degradation pathway."
] | [
1970
] | 1 | [
"IPR006035"
] | [] | 1 | 0 | 1 | [
"Bacteria",
"Eukaryota",
"Halobacteriales",
"ecological metagenomes"
] | [
4664,
3,
154,
6
] | 4 | [] | [] | 0 | true | Family | Formiminoglutamase | Formiminoglutamase | HutG | 1 |
IPR005925 | 5,925 | Agmatinase-related | Agmatinase-rel | Family | 17,079 | false | false | Members of this family include known and predicted examples of agmatinase (agmatine ureohydrolase, ) and members of archaea, for which no definitive agmatinase sequence has yet been made available [ ]. However, archaeal sequences are phylogenetically close to the experimentally verified Bacillus subtilis sequence. One ... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"TIGR01230"
] | [
"agmatinase"
] | [
17079
] | 1 | [
"EC",
"EC",
"GP",
"GP",
"GP",
"GP",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"3.5.3",
"3.5.3.11",
"GenProp0642",
"GenProp1279",
"GenProp1282",
"GenProp1596",
"PWY-40",
"R-HSA-351143",
"R-MMU-351143",
"R-RNO-351143"
] | [
"EC:3.5.3",
"EC:3.5.3.11",
"GP:GenProp0642",
"GP:GenProp1279",
"GP:GenProp1282",
"GP:GenProp1596",
"METACYC:PWY-40",
"REACTOME:R-HSA-351143",
"REACTOME:R-MMU-351143",
"REACTOME:R-RNO-351143"
] | 10 | [
"1gq6",
"1gq7",
"3lhl",
"3nio",
"3nip",
"3niq",
"3pzl",
"4dz4",
"7esr",
"7lba",
"7lol",
"7lox",
"7oi1"
] | 13 | [
"PUB00017651"
] | [
"10931887"
] | [
"Phylogeny of related functions: the case of polyamine biosynthetic enzymes."
] | [
2000
] | 1 | [
"IPR006035"
] | [
"IPR023694"
] | 1 | 1 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences",
"uncultured Caudovirales phage"
] | [
902,
14919,
947,
310,
1
] | 5 | [
"Danio rerio",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
2,
1,
1,
2
] | 5 | true | Family | Agmatinase-related | Agmatinase-related | Agmatinase-rel | 1 |
IPR005926 | 5,926 | Tagatose-6-phosphate kinase | LacC | Family | 846 | false | false | Tagatose-6-phosphate kinase ( ) is part of the tagatose-6-phosphate pathway of lactose degradation. The enzyme catalyses the following reaction: ATP + D-tagatose 6-phosphate = ADP + D-tagatose 1,6-bisphosphate The genes coding for the enzymes of the tagatose 6-phosphate pathway have been found to be part of the lac ope... | [
"GO:0009024",
"GO:0019512"
] | [
"tagatose-6-phosphate kinase activity",
"lactose catabolic process via tagatose-6-phosphate"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"HAMAP",
"NCBIFAM"
] | [
"MF_01557",
"TIGR01231"
] | [
"LacC",
"lacC"
] | [
577,
844
] | 2 | [
"EC",
"GP",
"METACYC",
"METACYC"
] | [
"2.7.1.144",
"GenProp0141",
"PWY-7077",
"PWY-7395"
] | [
"EC:2.7.1.144",
"GP:GenProp0141",
"METACYC:PWY-7077",
"METACYC:PWY-7395"
] | 4 | [
"2jg1",
"2jgv",
"2q5r"
] | 3 | [] | [] | [] | [] | 0 | [
"IPR017583"
] | [] | 1 | 0 | 1 | [
"Bacteria",
"human gut metagenome"
] | [
845,
1
] | 2 | [] | [] | 0 | true | Family | Tagatose-6-phosphate kinase | Tagatose-6-phosphate kinase | LacC | 2 |
IPR005927 | 5,927 | Tagatose 1,6-diphosphate aldolase | Tag_1.6-dipho_adolase | Family | 2,360 | false | false | Proteins from this entry are from Gram-positive bacteria and belong to the aldolase lacD family. Tagatose 1,6-diphosphate aldolase is a class I aldolase. It catalyses the reversible cleavage of four diastereoisomers (fructose 1,6-bisphosphate (FBP), psicose 1,6-bisphosphate, sorbose 1,6-bisphosphate, and tagatose 1,6-b... | [
"GO:0009024",
"GO:0019512"
] | [
"tagatose-6-phosphate kinase activity",
"lactose catabolic process via tagatose-6-phosphate"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"HAMAP",
"NCBIFAM",
"NCBIFAM",
"NCBIFAM"
] | [
"MF_00734",
"NF009065",
"NF009498",
"TIGR01232"
] | [
"LacD",
"PRK12399.1",
"PRK12858.1",
"lacD"
] | [
2032,
1726,
2360,
1467
] | 4 | [
"EC",
"GP",
"METACYC",
"METACYC",
"METACYC"
] | [
"4.1.2.40",
"GenProp0141",
"PWY-7077",
"PWY-7395",
"PWY-8324"
] | [
"EC:4.1.2.40",
"GP:GenProp0141",
"METACYC:PWY-7077",
"METACYC:PWY-7395",
"METACYC:PWY-8324"
] | 5 | [
"3iv3",
"3jrk",
"3kao",
"3mhf",
"3mhg",
"3myo",
"3myp",
"5f2g",
"5f2i",
"5f2l",
"5f2m",
"5f4s",
"5f4w",
"5ff7",
"5hjl",
"8tnf"
] | 16 | [
"PUB00040690",
"PUB00060480",
"PUB00060481",
"PUB00060482",
"PUB00060483",
"PUB00060484",
"PUB00104151"
] | [
"16843441",
"13950007",
"5972827",
"5793710",
"5816380",
"20427286",
"17371500"
] | [
"Stereoselectivity of fructose-1,6-bisphosphate aldolase in Thermus caldophilus.",
"The mechanism of action of aldolases. III. Schiff base formation with lysine.",
"Organic phosphate groups in native and borohydride-reduced aldolase.",
"A functional role of metal ions in a class II aldolase.",
"The molecula... | [
2006,
1962,
1966,
1969,
1969,
2010,
2007
] | 7 | [
"IPR002915"
] | [] | 1 | 0 | 1 | [
"Bacteria",
"Lotharella globosa",
"metagenomes"
] | [
2336,
1,
23
] | 3 | [] | [] | 0 | true | Family | Tagatose 1,6-diphosphate aldolase | Tagatose 1,6-diphosphate aldolase | Tag_1.6-dipho_adolase | 4 |
IPR005928 | 5,928 | 6-phospho-beta-galactosidase | 6P-beta-galactosidase | Family | 1,120 | false | false | 6-phospho-beta-galactosidase ( ) is part of the tagatose-6-phosphate pathway of galactose-6-phosphate degradation. A 6-phospho-beta-D-galactoside + H2O = an alcohol + 6-phospho-D-galactose The genes coding for the enzymes of the tagatose 6-phosphate pathway have been found to be part of the lac operon together with the... | [
"GO:0033920",
"GO:0019512"
] | [
"6-phospho-beta-galactosidase activity",
"lactose catabolic process via tagatose-6-phosphate"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"HAMAP",
"NCBIFAM"
] | [
"MF_01574",
"TIGR01233"
] | [
"LacG",
"lacG"
] | [
677,
1120
] | 2 | [
"EC"
] | [
"3.2.1.85"
] | [
"EC:3.2.1.85"
] | 1 | [
"1pbg",
"2pbg",
"3pbg",
"4pbg"
] | 4 | [] | [] | [] | [] | 0 | [
"IPR001360"
] | [] | 1 | 0 | 1 | [
"Bacteria",
"metagenomes"
] | [
1118,
2
] | 2 | [] | [] | 0 | true | Family | 6-phospho-beta-galactosidase | 6-phospho-beta-galactosidase | 6P-beta-galactosidase | 5 |
IPR005929 | 5,929 | Ribulokinase | Ribulokinase | Family | 5,916 | false | false | L-ribulokinase ( ) catalyses the MgATP-dependent phosphorylation of L(or D)-ribulose to produce L(or D)-ribulose 5-phosphate and ADP, which is the second step in arabinose catabolism: ATP + L/D-ribulose = ADP + L/D-ribulose 5-phosphate These proteins can also phosphorylates a variety of other sugar substrates including... | [
"GO:0005524",
"GO:0008741",
"GO:0019569"
] | [
"ATP binding",
"ribulokinase activity",
"L-arabinose catabolic process to D-xylulose 5-phosphate"
] | [
"molecular_function",
"molecular_function",
"biological_process"
] | 3 | [
"HAMAP",
"NCBIFAM",
"CDD"
] | [
"MF_00520",
"TIGR01234",
"cd07781"
] | [
"Ribulokinase",
"L-ribulokinase",
"ASKHA_NBD_FGGY_L-RBK"
] | [
3753,
4639,
5903
] | 3 | [
"EC",
"GP"
] | [
"2.7.1.16",
"GenProp1368"
] | [
"EC:2.7.1.16",
"GP:GenProp1368"
] | 2 | [
"3qdk"
] | 1 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
5762,
94,
60
] | 3 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Ribulokinase | Ribulokinase | Ribulokinase | 8 |
IPR005930 | 5,930 | Pyruvate carboxylase | Pyruv_COase | Family | 11,831 | false | false | In the postabsorptive state, blood glucose concentration is kept constant by a combination of glycogenolysis and gluconeogenesis. During prolonged fasting, when hepatic glycogen is exhausted, gluconeogenesis becomes the only source of plasma glucose. Gluconeogenesis (the production of new glucose molecules) occurs main... | [
"GO:0004736",
"GO:0005524",
"GO:0006090",
"GO:0006094"
] | [
"pyruvate carboxylase activity",
"ATP binding",
"pyruvate metabolic process",
"gluconeogenesis"
] | [
"molecular_function",
"molecular_function",
"biological_process",
"biological_process"
] | 4 | [
"PIRSF",
"NCBIFAM"
] | [
"PIRSF001594",
"TIGR01235"
] | [
"Pyruv_carbox",
"pyruv_carbox"
] | [
11240,
11688
] | 2 | [
"EC",
"GP",
"METACYC",
"METACYC",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME... | [
"6.4.1.1",
"GenProp1612",
"PWY-6142",
"PWY-6146",
"PWY-8086",
"R-BTA-196780",
"R-BTA-70263",
"R-BTA-70268",
"R-CEL-196780",
"R-CEL-70263",
"R-CEL-70268",
"R-HSA-196780",
"R-HSA-3371599",
"R-HSA-70263",
"R-HSA-70268",
"R-MMU-196780",
"R-MMU-70263",
"R-MMU-70268",
"R-RNO-196780",
... | [
"EC:6.4.1.1",
"GP:GenProp1612",
"METACYC:PWY-6142",
"METACYC:PWY-6146",
"METACYC:PWY-8086",
"REACTOME:R-BTA-196780",
"REACTOME:R-BTA-70263",
"REACTOME:R-BTA-70268",
"REACTOME:R-CEL-196780",
"REACTOME:R-CEL-70263",
"REACTOME:R-CEL-70268",
"REACTOME:R-HSA-196780",
"REACTOME:R-HSA-3371599",
"... | 27 | [
"2qf7",
"3bg5",
"3hb9",
"3hbl",
"3ho8",
"3tw6",
"3tw7",
"4hnt",
"4hnu",
"4hnv",
"4qsh",
"4qsk",
"4qsl",
"5vyw",
"5vyz",
"5vz0",
"7wta",
"7wtb",
"7wtc",
"7wtd",
"7wte",
"7zyy",
"7zyz",
"7zz0",
"7zz1",
"7zz2",
"7zz3",
"7zz4",
"7zz5",
"7zz6",
"7zz8",
"8gk8"... | 36 | [] | [] | [] | [] | 0 | [
"IPR055268"
] | [] | 1 | 0 | 1 | [
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
8002,
3783,
46
] | 3 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strai... | [
1,
2,
3,
1,
8,
1,
5,
2,
1
] | 9 | true | Family | Pyruvate carboxylase | Pyruvate carboxylase | Pyruv_COase | 7 |
IPR005931 | 5,931 | Delta-1-pyrroline-5-carboxylate dehydrogenase | P5CDH/ALDH4A1 | Family | 9,876 | false | false | This entry represents one of two related branches of delta-1-pyrroline-5-carboxylate dehydrogenase (P5CDH, ; also known as ALDH4A1 in humans). It is responsible for the NAD + -dependent, irreversible conversion of delta-1-pyrroline-5-carboxylate (P5C), derived either from proline or ornithine, to glutamate [ , ]. This ... | [
"GO:0003842",
"GO:0010133"
] | [
"L-glutamate gamma-semialdehyde dehydrogenase activity",
"L-proline catabolic process to L-glutamate"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"NCBIFAM",
"CDD"
] | [
"TIGR01236",
"cd07123"
] | [
"D1pyr5carbox1",
"ALDH_F4-17_P5CDH"
] | [
9784,
7669
] | 2 | [
"EC",
"GP",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"1.2.1.88",
"GenProp1428",
"PWY-6853",
"R-BTA-389661",
"R-BTA-70688",
"R-DRE-389661",
"R-DRE-70688",
"R-HSA-389661",
"R-HSA-70688",
"R-MMU-389661",
"R-MMU-70688",
"R-RNO-389661",
"R-RNO-70688"
] | [
"EC:1.2.1.88",
"GP:GenProp1428",
"METACYC:PWY-6853",
"REACTOME:R-BTA-389661",
"REACTOME:R-BTA-70688",
"REACTOME:R-DRE-389661",
"REACTOME:R-DRE-70688",
"REACTOME:R-HSA-389661",
"REACTOME:R-HSA-70688",
"REACTOME:R-MMU-389661",
"REACTOME:R-MMU-70688",
"REACTOME:R-RNO-389661",
"REACTOME:R-RNO-70... | 13 | [
"3v9g",
"3v9h",
"3v9i",
"3v9j",
"3v9k",
"3v9l",
"4e3x",
"4idm",
"4ids",
"4ihi",
"4jdc",
"4lem",
"4lgz",
"4lh0",
"4lh1",
"4lh2",
"4lh3",
"4ns3",
"4oe4",
"4oe5",
"4oe6",
"7mer",
"7mes",
"8rkq",
"8rkr"
] | 25 | [
"PUB00059319",
"PUB00081165",
"PUB00081167",
"PUB00081174"
] | [
"22516612",
"18611112",
"18369526",
"12604184"
] | [
"The Three-Dimensional Structural Basis of Type II Hyperprolinemia.",
"Non-P450 aldehyde oxidizing enzymes: the aldehyde dehydrogenase superfamily.",
"Structural biology of proline catabolism.",
"Aldehyde dehydrogenase gene superfamily: the 2002 update."
] | [
2012,
2008,
2008,
2003
] | 4 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
24,
5338,
4451,
63
] | 4 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strai... | [
3,
1,
2,
2,
1,
1,
10,
1,
1
] | 9 | true | Family | Delta-1-pyrroline-5-carboxylate dehydrogenase | Delta-1-pyrroline-5-carboxylate dehydrogenase | P5CDH/ALDH4A1 | 9 |
IPR005932 | 5,932 | 1-pyrroline-5-carboxylate dehydrogenase | RocA | Family | 2,788 | false | false | This entry represents a group of 1-pyrroline-5-carboxylate dehydrogenases (RocA) from Bacillales [ ] and other bacteria [ ]. They are related to delta-1-pyrroline-5-carboxylate dehydrogenase ( ; ) [ ], which is an aldehyde dehydrogenase that catalyses the oxidation of glutamate semialdehyde to glutamate [ ], utilizing ... | [] | [] | [] | 0 | [
"NCBIFAM",
"CDD"
] | [
"TIGR01237",
"cd07124"
] | [
"D1pyr5carbox2",
"ALDH_PutA-P5CDH-RocA"
] | [
2586,
2786
] | 2 | [
"EC",
"METACYC"
] | [
"1.2.1.88",
"PWY-6853"
] | [
"EC:1.2.1.88",
"METACYC:PWY-6853"
] | 2 | [
"1uzb",
"2bhp",
"2bhq",
"2bja",
"2bjk",
"2ehq",
"2ehu",
"2eii",
"2eit",
"2eiw",
"2ej6",
"2ejd",
"2ejl",
"2iy6",
"2j40",
"2j5n",
"3qan",
"3rjl",
"4k57",
"4nm9",
"4nma",
"4nmb",
"4nmc",
"4nmd",
"4nme",
"4nmf",
"5ur2",
"7na0"
] | 28 | [
"PUB00037904",
"PUB00059319",
"PUB00081174",
"PUB00081175",
"PUB00081176",
"PUB00081177",
"PUB00081178"
] | [
"16934832",
"22516612",
"12604184",
"12634342",
"15966737",
"18931443",
"18324349"
] | [
"Crystal structure of Thermus thermophilus Delta1-pyrroline-5-carboxylate dehydrogenase.",
"The Three-Dimensional Structural Basis of Type II Hyperprolinemia.",
"Aldehyde dehydrogenase gene superfamily: the 2002 update.",
"Specificity of the interaction of RocR with the rocG-rocA intergenic region in Bacillus... | [
2006,
2012,
2003,
2003,
2005,
2008,
2008
] | 7 | [] | [
"IPR047597"
] | 0 | 1 | 0 | [
"Archaea",
"Bacteria",
"Biomphalaria pfeifferi",
"ecological metagenomes"
] | [
11,
2767,
1,
9
] | 4 | [] | [] | 0 | true | Family | 1-pyrroline-5-carboxylate dehydrogenase | 1-pyrroline-5-carboxylate dehydrogenase | RocA | 7 |
IPR005933 | 5,933 | Bifunctional protein PutA, C-terminal domain | PutA_C | Domain | 9,647 | false | false | This entry represents the C-terminal domain of Bifunctional protein PutA from Escherichia coli [ ] and similar sequences predominantly found in proteobacteria. This domain corresponds to the aldehyde dehydrogenase activity (Delta-1-pyrroline-5-carboxylate dehydrogenase, ) of PutA, which is critical in the de novo biosy... | [
"GO:0003842",
"GO:0055129"
] | [
"L-glutamate gamma-semialdehyde dehydrogenase activity",
"L-proline biosynthetic process"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"NCBIFAM"
] | [
"TIGR01238"
] | [
"D1pyr5carbox3"
] | [
9647
] | 1 | [
"EC",
"EC",
"GP",
"METACYC",
"METACYC",
"METACYC"
] | [
"1.2.1.88",
"1.5.5.2",
"GenProp1401",
"PWY-5737",
"PWY-6853",
"PWY-6922"
] | [
"EC:1.2.1.88",
"EC:1.5.5.2",
"GP:GenProp1401",
"METACYC:PWY-5737",
"METACYC:PWY-6853",
"METACYC:PWY-6922"
] | 6 | [
"3haz",
"4q71",
"4q72",
"4q73",
"5kf6",
"5kf7",
"6bsn",
"6ufp",
"6vz9",
"6x99",
"6x9a",
"6x9b",
"6x9c",
"6x9d",
"7my9",
"7mya",
"7myb",
"7myc",
"9bbo",
"9c34",
"9c35",
"9c36",
"9c8c",
"9dl2",
"9dl3",
"9dl4",
"9dl5",
"9dl6",
"9dl7",
"9dl8",
"9dl9",
"9e0a"... | 37 | [
"PUB00003335",
"PUB00106872"
] | [
"7966312",
"20133651"
] | [
"Sequence analysis identifies the proline dehydrogenase and delta 1-pyrroline-5-carboxylate dehydrogenase domains of the multifunctional Escherichia coli PutA protein.",
"Crystal structure of the bifunctional proline utilization A flavoenzyme from Bradyrhizobium japonicum."
] | [
1994,
2010
] | 2 | [
"IPR015590"
] | [] | 1 | 0 | 1 | [
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
9578,
16,
53
] | 3 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Domain | Bifunctional protein PutA, C-terminal domain | Bifunctional protein PutA, C-terminal domain | PutA_C | 7 |
IPR005935 | 5,935 | Diphosphomevalonate/phosphomevalonate decarboxylase | Mev_decarb | Family | 8,526 | false | false | This group of enzymes belongs to the GHMP kinase domain superfamily. GHMP kinases are a unique class of ATP-dependent enzymes (the abbreviation of which refers to the original members: galactokinase, homoserine kinase, mevalonate kinase, and phosphomevalonate kinase) [ ]. Enzymes belonging to this superfamily contain t... | [
"GO:0016831",
"GO:0008299"
] | [
"carboxy-lyase activity",
"isoprenoid biosynthetic process"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PIRSF"
] | [
"PIRSF015950"
] | [
"Mev_P_decrbx"
] | [
8526
] | 1 | [
"EC",
"METACYC",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"4.1.1.33",
"PWY-7391",
"PWY-922",
"R-BTA-191273",
"R-BTA-446199",
"R-DDI-191273",
"R-DDI-446199",
"R-DRE-191273",
"R-DRE-446199",
"R-HSA-191273",
"R-HSA-2426168",
"R-HSA-446199",
"R-MMU-191273",
"R-MMU-446199",
"R-RNO-191273",
"R-RNO-446199",
"R-SCE-191273",
"R-SCE-446199",
"R-S... | [
"EC:4.1.1.33",
"METACYC:PWY-7391",
"METACYC:PWY-922",
"REACTOME:R-BTA-191273",
"REACTOME:R-BTA-446199",
"REACTOME:R-DDI-191273",
"REACTOME:R-DDI-446199",
"REACTOME:R-DRE-191273",
"REACTOME:R-DRE-446199",
"REACTOME:R-HSA-191273",
"REACTOME:R-HSA-2426168",
"REACTOME:R-HSA-446199",
"REACTOME:R-... | 20 | [
"1fi4",
"2gs8",
"2hk2",
"2hk3",
"2hke",
"3d4j",
"3f0n",
"3lto",
"3qt5",
"3qt6",
"3qt7",
"3qt8",
"4dpt",
"4dpu",
"4dpw",
"4dpx",
"4dpy",
"4du7",
"4du8",
"4z7c",
"4z7y",
"5gmd",
"5gme",
"5v2l",
"5v2m",
"6e2s",
"6e2t",
"6e2u",
"6e2v",
"6e2w",
"6e2y",
"6n0x"... | 37 | [
"PUB00015644",
"PUB00015669",
"PUB00015675",
"PUB00015730",
"PUB00015835",
"PUB00016172",
"PUB00069710"
] | [
"11188689",
"12771135",
"8382990",
"12001237",
"12796487",
"7947744",
"24375100"
] | [
"Structure and mechanism of homoserine kinase: prototype for the GHMP kinase superfamily.",
"Crystal structure of 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase, an enzyme in the non-mevalonate pathway of isoprenoid synthesis.",
"Convergent evolution of similar enzymatic function on different protein ... | [
2000,
2003,
1993,
2002,
2003,
1994,
2013
] | 7 | [] | [
"IPR029765",
"IPR049864"
] | 0 | 2 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
428,
3982,
4095,
21
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
7,
1,
1,
1,
2,
2,
1,
2,
5,
1,
1,
11
] | 12 | true | Family | Diphosphomevalonate/phosphomevalonate decarboxylase | Diphosphomevalonate/phosphomevalonate decarboxylase | Mev_decarb | 2 |
IPR005936 | 5,936 | ATP-dependent zinc metalloprotease, FtsH | FtsH | Family | 48,627 | false | false | This entry represents the ATP-dependent zinc metalloprotease FtsH family. AAA proteases are ATP-dependent metallopeptidases present in eubacteria as well as in organelles of bacterial origin, i.e., mitochondria and chloroplasts. The AAA proteases are also known as FtsH, referring to the Escherichia coli enzyme (Filamen... | [
"GO:0004176",
"GO:0004222",
"GO:0016020"
] | [
"ATP-dependent peptidase activity",
"metalloendopeptidase activity",
"membrane"
] | [
"molecular_function",
"molecular_function",
"cellular_component"
] | 3 | [
"HAMAP",
"NCBIFAM"
] | [
"MF_01458",
"TIGR01241"
] | [
"FtsH",
"FtsH_fam"
] | [
47913,
47208
] | 2 | [
"EC",
"GP",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"3.4.24.-",
"GenProp0684",
"PWY-8119",
"R-BTA-8949664",
"R-BTA-9837999",
"R-CEL-8949664",
"R-CEL-9837999",
"R-DME-8949664",
"R-DME-9837999",
"R-HSA-8949664",
"R-HSA-9837999",
"R-HSA-9840373",
"R-MMU-8949664",
"R-MMU-9837999",
"R-MMU-9840373",
"R-RNO-8949664",
"R-RNO-9837999",
"R-RN... | [
"EC:3.4.24.-",
"GP:GenProp0684",
"METACYC:PWY-8119",
"REACTOME:R-BTA-8949664",
"REACTOME:R-BTA-9837999",
"REACTOME:R-CEL-8949664",
"REACTOME:R-CEL-9837999",
"REACTOME:R-DME-8949664",
"REACTOME:R-DME-9837999",
"REACTOME:R-HSA-8949664",
"REACTOME:R-HSA-9837999",
"REACTOME:R-HSA-9840373",
"REAC... | 22 | [
"2ce7",
"2cea",
"2dhr",
"3kds",
"4eiw",
"4ww0",
"4z8x",
"6gcn",
"6gco",
"6nyy",
"7tdo",
"7vhp",
"7wi3",
"7wi4",
"7zbh",
"8vw9",
"8vwa",
"8vwb",
"8vwc",
"9cz2"
] | 20 | [
"PUB00007912",
"PUB00068180",
"PUB00068182",
"PUB00068183",
"PUB00068184"
] | [
"12037319",
"22498346",
"19656850",
"16966379",
"20657548"
] | [
"Crystallization of the AAA domain of the ATP-dependent protease FtsH of Escherichia coli.",
"Protein quality control in organelles - AAA/FtsH story.",
"Autocatalytic processing of m-AAA protease subunits in mitochondria.",
"A new function in translocation for the mitochondrial i-AAA protease Yme1: import of ... | [
2002,
2013,
2009,
2006,
2010
] | 5 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
31727,
16396,
7,
497
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
43,
2,
8,
6,
1,
12,
7,
2,
13,
16,
3,
2,
53
] | 13 | true | Family | ATP-dependent zinc metalloprotease, FtsH | ATP-dependent zinc metalloprotease, FtsH | FtsH | 4 |
IPR005939 | 5,939 | Beta-lactamase hydrolase-like protein, phosphatase-like domain | BLH_phosphatase-like | Domain | 5,725 | false | false | This domain is found N-terminal to a beta-lactamase domain, and it may have phosphatase activity [ ]. This domain is found in Beta-lactamase hydrolase-like protein from Agrobacterium fabrum, which may play a role in cell adherence or biofilm development [ ]. | [
"GO:0016787"
] | [
"hydrolase activity"
] | [
"molecular_function"
] | 1 | [
"PFAM",
"NCBIFAM"
] | [
"PF04273",
"TIGR01244"
] | [
"BLH_phosphatase",
""
] | [
5725,
4797
] | 2 | [] | [] | [] | 0 | [
"2f46"
] | 1 | [
"PUB00097612",
"PUB00097613"
] | [
"17586627",
"17636569"
] | [
"BigR, a transcriptional repressor from plant-associated bacteria, regulates an operon implicated in biofilm growth.",
"Crystal structure of NMA1982 from Neisseria meningitidis at 1.5 angstroms resolution provides a structural scaffold for nonclassical, eukaryotic-like phosphatases."
] | [
2007,
2007
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
5675,
8,
42
] | 3 | [] | [] | 0 | true | Domain | Beta-lactamase hydrolase-like protein, phosphatase-like domain | Beta-lactamase hydrolase-like protein, phosphatase-like domain | BLH_phosphatase-like | 6 |
IPR005940 | 5,940 | Anthranilate phosphoribosyl transferase | Anthranilate_Pribosyl_Tfrase | Family | 32,374 | false | false | In many widely different species, including Escherichia coli, Thermotoga maritima, and Archaeoglobus fulgidus, this enzyme is a C-terminal part of a multifunctional protein together with glutamine amidotransferase; the fusion protein is designated anthranilate synthase component II ( ). | [
"GO:0004048",
"GO:0000162"
] | [
"anthranilate phosphoribosyltransferase activity",
"L-tryptophan biosynthetic process"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"HAMAP",
"PANTHER",
"NCBIFAM"
] | [
"MF_00211",
"PTHR43285",
"TIGR01245"
] | [
"TrpD",
"",
"trpD"
] | [
24717,
32353,
26348
] | 3 | [
"EC",
"GP",
"GP",
"GP",
"GP"
] | [
"2.4.2.18",
"GenProp0037",
"GenProp1450",
"GenProp1538",
"GenProp1550"
] | [
"EC:2.4.2.18",
"GP:GenProp0037",
"GP:GenProp1450",
"GP:GenProp1538",
"GP:GenProp1550"
] | 5 | [
"1gxb",
"1kgz",
"1khd",
"1o17",
"1v8g",
"1vqu",
"1zvw",
"1zxy",
"1zyk",
"2bpq",
"2elc",
"2gvq",
"3gbr",
"3qqs",
"3qr9",
"3qs8",
"3qsa",
"3r6c",
"3r88",
"3twp",
"3uu1",
"4giu",
"4gkm",
"4gtn",
"4hkm",
"4ij1",
"4m0r",
"4muo",
"4n5v",
"4n8q",
"4n93",
"4owm"... | 67 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
1133,
27432,
3132,
677
] | 4 | [
"Arabidopsis thaliana",
"Escherichia coli (strain K12)",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)",
"Zea mays"
] | [
4,
2,
1,
5,
1,
1,
7
] | 7 | true | Family | Anthranilate phosphoribosyl transferase | Anthranilate phosphoribosyl transferase | Anthranilate_Pribosyl_Tfrase | 6 |
IPR005941 | 5,941 | Succinyl-diaminopimelate desuccinylase, proteobacteria | DapE_proteobac | Family | 10,369 | false | false | This entry represents succinyl-diaminopimelate desuccinylase from proteobacteria (DapE, ), which hydrolyses N-succinyl-L,L-diaminopimelic acid to L,L-diaminopimelic acid (L,L-DAP) [ ]. L,L-DAP is required for the bacterial synthesis of lysine and meso-diaminopimelic acid. It has been shown that DapE is essential for ce... | [
"GO:0009014",
"GO:0009089"
] | [
"succinyl-diaminopimelate desuccinylase activity",
"L-lysine biosynthetic process via diaminopimelate"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"HAMAP",
"NCBIFAM",
"NCBIFAM"
] | [
"MF_01690",
"NF009557",
"TIGR01246"
] | [
"DapE",
"PRK13009.1",
"dapE_proteo"
] | [
10078,
10360,
10147
] | 3 | [
"EC",
"GP"
] | [
"3.5.1.18",
"GenProp0786"
] | [
"EC:3.5.1.18",
"GP:GenProp0786"
] | 2 | [
"1vgy",
"3ic1",
"3isz",
"4o23",
"4ppz",
"4pqa",
"5uej",
"5vo3",
"7lgp",
"7t1q",
"8f8o"
] | 11 | [
"PUB00003579",
"PUB00054869",
"PUB00070660",
"PUB00079911",
"PUB00079912",
"PUB00079913",
"PUB00079914",
"PUB00079915",
"PUB00079954",
"PUB00079955"
] | [
"7674922",
"20138056",
"12896993",
"12962500",
"14640610",
"16421726",
"9671518",
"3276674",
"18712420",
"19822427"
] | [
"Evolutionary families of metallopeptidases.",
"Structural basis for catalysis by the mono- and dimetalated forms of the dapE-encoded N-succinyl-L,L-diaminopimelic acid desuccinylase.",
"DapE can function as an aspartyl peptidase in the presence of Mn2+.",
"Substrate specificity, metal binding properties, and... | [
1995,
2010,
2003,
2003,
2003,
2006,
1998,
1988,
2009,
2009
] | 10 | [
"IPR002933"
] | [] | 1 | 0 | 1 | [
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
10205,
32,
132
] | 3 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Succinyl-diaminopimelate desuccinylase, proteobacteria | Succinyl-diaminopimelate desuccinylase, proteobacteria | DapE_proteobac | 5 |
IPR005942 | 5,942 | Daunorubicin resistance ABC transporter membrane protein | Daunbcin-R_ABC-transpt | Family | 271 | false | false | This entry represents the Daunorubicin resistance ABC transporter membrane protein, which is associated with the efflux of the drug daunorubicin and found in bacteria and archaea. It functions as an ATP dependent antiporter. In eukaryotes, proteins of similar function include p-glyco-proteins and a multidrug resistance... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"TIGR01247"
] | [
"drrB"
] | [
271
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00004290",
"PUB00014769",
"PUB00017894",
"PUB00017895",
"PUB00017896",
"PUB00017897",
"PUB00017898",
"PUB00017899",
"PUB00025109",
"PUB00026406",
"PUB00043654"
] | [
"9872322",
"9873074",
"11421269",
"1282354",
"9640644",
"11988180",
"11470432",
"11402022",
"11080142",
"11532960",
"11421270"
] | [
"Crystal structure of the ATP-binding subunit of an ABC transporter.",
"Getting in or out: early segregation between importers and exporters in the evolution of ATP-binding cassette (ABC) transporters.",
"ABC transporters: physiology, structure and mechanism--an overview.",
"ABC transporters: from microorgani... | [
1998,
1999,
2001,
1992,
1998,
2002,
2001,
2001,
2000,
2001,
2001
] | 11 | [
"IPR000412"
] | [] | 1 | 0 | 1 | [
"Archaea",
"Bacteria",
"ecological metagenomes"
] | [
213,
52,
6
] | 3 | [] | [] | 0 | true | Family | Daunorubicin resistance ABC transporter membrane protein | Daunorubicin resistance ABC transporter membrane protein | Daunbcin-R_ABC-transpt | 6 |
IPR005943 | 5,943 | Daunorubicin resistance protein C | Daunbcin-R_C | Family | 183 | false | false | Daunorubicin resistance protein C confers the function of daunorubicin resistance. The protein seems to share strong sequence similarity to UvrA proteins, which are involved in excision repair of DNA. Disruption of drrC gene showed increased sensitivity upon exposure to duanorubicin, however it failed to complement uvr... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"TIGR01248"
] | [
"drrC"
] | [
183
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [
"IPR000412"
] | [] | 1 | 0 | 1 | [
"Mycobacteriales"
] | [
183
] | 1 | [] | [] | 0 | true | Family | Daunorubicin resistance protein C | Daunorubicin resistance protein C | Daunbcin-R_C | 3 |
IPR005944 | 5,944 | Proline iminopeptidase | Pro_iminopeptidase | Family | 14,353 | false | false | This entry describes a family of proline iminopeptidases ( ), which are Mn2+-requiring enzymes present in the cytosol of mammalian and microbial cells. They release an N-terminal residue from a peptide, preferably (but not exclusively) a proline. | [
"GO:0004177",
"GO:0006508",
"GO:0005737"
] | [
"aminopeptidase activity",
"proteolysis",
"cytoplasm"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PIRSF",
"PANTHER",
"NCBIFAM"
] | [
"PIRSF006431",
"PTHR43722",
"TIGR01249"
] | [
"Pept_S33",
"",
"pro_imino_pep_1"
] | [
10427,
14341,
10726
] | 3 | [
"EC"
] | [
"3.4.11.5"
] | [
"EC:3.4.11.5"
] | 1 | [
"1azw",
"1qtr",
"1wm1",
"1x2b",
"1x2e",
"5yhp"
] | 6 | [] | [] | [] | [] | 0 | [
"IPR002410"
] | [] | 1 | 0 | 1 | [
"Archaea",
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
7,
12250,
1962,
134
] | 4 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
8,
5,
12
] | 3 | true | Family | Proline iminopeptidase | Proline iminopeptidase | Pro_iminopeptidase | 6 |
IPR005945 | 5,945 | Proline-specific peptidase | Pro_imino_pep | Family | 6,443 | false | false | This entry describes a subfamily of the α/β fold family of hydrolases. Characterised members include prolyl aminopeptidases, also known as Proline iminopeptidase (PAP, ), and L-amino acid amidase ( ). | [
"GO:0008233",
"GO:0006508"
] | [
"peptidase activity",
"proteolysis"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PIRSF",
"NCBIFAM"
] | [
"PIRSF005539",
"TIGR01250"
] | [
"Pept_S33_TRI_F1",
"pro_imino_pep_2"
] | [
6107,
6210
] | 2 | [
"EC"
] | [
"3.4.11.5"
] | [
"EC:3.4.11.5"
] | 1 | [
"1mt3",
"1mtz",
"1mu0",
"1xqv",
"1xqw",
"1xqx",
"1xqy",
"1xrl",
"1xrm",
"1xrn",
"1xro",
"1xrp",
"1xrq",
"1xrr",
"3nwo",
"3wmr",
"7a6g"
] | 17 | [] | [] | [] | [] | 0 | [
"IPR002410"
] | [] | 1 | 0 | 1 | [
"Archaea",
"Bacteria",
"Eukaryota",
"ecological metagenomes"
] | [
67,
4926,
1388,
62
] | 4 | [] | [] | 0 | true | Family | Proline-specific peptidase | Proline-specific peptidase | Pro_imino_pep | 2 |
IPR005946 | 5,946 | Ribose-phosphate pyrophosphokinase | Rib-P_diPkinase | Family | 51,495 | false | false | Ribose-phosphate diphosphokinase, also known as ribose-phosphate pyrophosphokinase (RPPK), or phosphoribosyldiphosphate synthetase ( ), catalyses the transfer of an intact diphosphate (PP) group from ATP to ribose-5-phosphate (R-5-P), which results in the formation of AMP and 5-phospho-D-ribosyl--1-diphosphate (PRPP). | [
"GO:0000287",
"GO:0009165"
] | [
"magnesium ion binding",
"nucleotide biosynthetic process"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PFAM",
"PANTHER",
"NCBIFAM"
] | [
"PF14572",
"PTHR10210",
"TIGR01251"
] | [
"Pribosyl_synth",
"",
"ribP_PPkin"
] | [
41512,
51306,
47548
] | 3 | [
"EC",
"GP",
"GP",
"GP",
"GP",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"2.7.6.1",
"GenProp0037",
"GenProp0109",
"GenProp0110",
"GenProp0187",
"R-BTA-73843",
"R-DDI-73843",
"R-HSA-73843",
"R-MMU-73843",
"R-RNO-73843",
"R-SCE-73843",
"R-SPO-73843",
"R-XTR-73843"
] | [
"EC:2.7.6.1",
"GP:GenProp0037",
"GP:GenProp0109",
"GP:GenProp0110",
"GP:GenProp0187",
"REACTOME:R-BTA-73843",
"REACTOME:R-DDI-73843",
"REACTOME:R-HSA-73843",
"REACTOME:R-MMU-73843",
"REACTOME:R-RNO-73843",
"REACTOME:R-SCE-73843",
"REACTOME:R-SPO-73843",
"REACTOME:R-XTR-73843"
] | 13 | [
"1dkr",
"1dku",
"1ibs",
"1u9y",
"1u9z",
"2c4k",
"2h06",
"2h07",
"2h08",
"2hcr",
"2ji4",
"3dah",
"3efh",
"3lpn",
"3lrt",
"3mbi",
"3nag",
"3s5j",
"4f8e",
"4lyg",
"4lzn",
"4lzo",
"4m0p",
"4m0u",
"4s2u",
"4twb",
"5mp7",
"5t3o",
"6asv",
"6nfe",
"7pn0",
"7xmu"... | 52 | [] | [] | [] | [] | 0 | [] | [
"IPR037514",
"IPR037515"
] | 0 | 2 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
968,
30285,
19026,
481,
735
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
20,
5,
10,
17,
1,
46,
19,
5,
17,
23,
5,
3,
31
] | 13 | true | Family | Ribose-phosphate pyrophosphokinase | Ribose-phosphate pyrophosphokinase | Rib-P_diPkinase | 5 |
IPR005947 | 5,947 | Thiamine ABC transporter, permease protein | ThiP_ABC_transpt | Family | 2,918 | false | false | ABC transporters belong to the ATP-Binding Cassette (ABC) superfamily, which uses the hydrolysis of ATP to energise diverse biological systems. ABC transporters minimally consist of two conserved regions: a highly conserved ATP binding cassette (ABC) and a less conserved transmembrane domain (TMD). These can be found o... | [
"GO:0022857",
"GO:0015888",
"GO:0016020"
] | [
"transmembrane transporter activity",
"thiamine transport",
"membrane"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"NCBIFAM"
] | [
"TIGR01253"
] | [
"thiP"
] | [
2918
] | 1 | [
"GP"
] | [
"GenProp0252"
] | [
"GP:GenProp0252"
] | 1 | [] | 0 | [
"PUB00004290",
"PUB00014769",
"PUB00017654",
"PUB00017894",
"PUB00017895",
"PUB00017896",
"PUB00017897",
"PUB00017898",
"PUB00017899",
"PUB00025109",
"PUB00026406",
"PUB00043654"
] | [
"9872322",
"9873074",
"9535878",
"11421269",
"1282354",
"9640644",
"11988180",
"11470432",
"11402022",
"11080142",
"11532960",
"11421270"
] | [
"Crystal structure of the ATP-binding subunit of an ABC transporter.",
"Getting in or out: early segregation between importers and exporters in the evolution of ATP-binding cassette (ABC) transporters.",
"thiBPQ encodes an ABC transporter required for transport of thiamine and thiamine pyrophosphate in Salmonel... | [
1998,
1999,
1998,
2001,
1992,
1998,
2002,
2001,
2001,
2000,
2001,
2001
] | 12 | [] | [] | 0 | 0 | null | [
"Bacteria",
"ecological metagenomes"
] | [
2915,
3
] | 2 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Thiamine ABC transporter, permease protein | Thiamine ABC transporter, permease protein | ThiP_ABC_transpt | 5 |
IPR005948 | 5,948 | Thiamine/thiamin pyrophosphate-binding periplasmic protein, ABC transporter | ThiB-like | Family | 6,326 | false | false | Bacterial high affinity transport systems are involved in active transport of solutes across the cytoplasmic membrane. Most of the bacterial ABC (ATP-binding cassette) importers are composed of one or two transmembrane permease proteins, one or two nucleotide-binding proteins and a highly specific periplasmic solute-bi... | [
"GO:0030975",
"GO:0015888"
] | [
"thiamine binding",
"thiamine transport"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"NCBIFAM",
"CDD"
] | [
"TIGR01254",
"cd13545"
] | [
"sfuA",
"PBP2_TbpA"
] | [
6326,
4820
] | 2 | [] | [] | [] | 0 | [
"2qry"
] | 1 | [
"PUB00017654",
"PUB00049123",
"PUB00071925",
"PUB00071938"
] | [
"9535878",
"18177053",
"18310026",
"8003968"
] | [
"thiBPQ encodes an ABC transporter required for transport of thiamine and thiamine pyrophosphate in Salmonella typhimurium.",
"Structural similarities between thiamin-binding protein and thiaminase-I suggest a common ancestor.",
"Characterization of a Pseudomonas putida ABC transporter (AatJMQP) required for ac... | [
1998,
2008,
2008,
1994
] | 4 | [] | [
"IPR005967"
] | 0 | 1 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
411,
5795,
5,
115
] | 4 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Thiamine/thiamin pyrophosphate-binding periplasmic protein, ABC transporter | Thiamine/thiamin pyrophosphate-binding periplasmic protein, ABC transporter | ThiB-like | 1 |
IPR005949 | 5,949 | Formate acetyltransferase | Form_AcTrfase | Family | 8,752 | false | false | Pyruvate formate-lyase (also known as formate C-acetyltransferase) is an enzyme which converts acetyl-CoA and formate to CoA and pyruvate. Acetyl-CoA + formate = CoA + pyruvate In Escherichia coli, it uses a radical mechanism to reversibly cleave the C1-C2 bond of pyruvate using the Gly 734 radical and two cysteine res... | [
"GO:0008861",
"GO:0005975",
"GO:0005737"
] | [
"formate C-acetyltransferase activity",
"carbohydrate metabolic process",
"cytoplasm"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"NCBIFAM",
"CDD"
] | [
"TIGR01255",
"cd01678"
] | [
"pyr_form_ly_1",
"PFL1"
] | [
8733,
8082
] | 2 | [
"EC",
"GP",
"GP",
"GP",
"GP",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC"
] | [
"2.3.1.54",
"GenProp0943",
"GenProp1267",
"GenProp1425",
"GenProp1543",
"PWY-5437",
"PWY-5480",
"PWY-5485",
"PWY-5493",
"PWY-8086"
] | [
"EC:2.3.1.54",
"GP:GenProp0943",
"GP:GenProp1267",
"GP:GenProp1425",
"GP:GenProp1543",
"METACYC:PWY-5437",
"METACYC:PWY-5480",
"METACYC:PWY-5485",
"METACYC:PWY-5493",
"METACYC:PWY-8086"
] | 10 | [
"1cm5",
"1h16",
"1h17",
"1h18",
"1mzo",
"1qhm",
"2pfl",
"3pfl"
] | 8 | [
"PUB00007412"
] | [
"10504733"
] | [
"Structure and mechanism of the glycyl radical enzyme pyruvate formate-lyase."
] | [
1999
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Siphoviridae sp. ctHip2",
"metagenomes"
] | [
8623,
111,
1,
17
] | 4 | [
"Escherichia coli (strain K12)"
] | [
2
] | 1 | true | Family | Formate acetyltransferase | Formate acetyltransferase | Form_AcTrfase | 3 |
IPR005951 | 5,951 | Retinal-specific ATP-binding cassette transporter | ABCA4/ABCR | Family | 228 | false | false | The ABC transporter family is a group of membrane proteins that use the hydrolysis of ATP to power the translocation of a wide variety of substrates across cellular membranes. ABC transporters minimally consist of two conserved regions: a highly conserved nucleotide-binding domain (NBD) and a less conserved transmembra... | [
"GO:0005524",
"GO:0140359",
"GO:0006869",
"GO:0007601",
"GO:0005886"
] | [
"ATP binding",
"ABC-type transporter activity",
"lipid transport",
"visual perception",
"plasma membrane"
] | [
"molecular_function",
"molecular_function",
"biological_process",
"biological_process",
"cellular_component"
] | 5 | [
"NCBIFAM"
] | [
"TIGR01257"
] | [
"rim_protein"
] | [
228
] | 1 | [
"EC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"7.6.2.1",
"R-BTA-2453902",
"R-BTA-382556",
"R-HSA-2453902",
"R-HSA-382556",
"R-HSA-9918454",
"R-MMU-2453902",
"R-MMU-382556"
] | [
"EC:7.6.2.1",
"REACTOME:R-BTA-2453902",
"REACTOME:R-BTA-382556",
"REACTOME:R-HSA-2453902",
"REACTOME:R-HSA-382556",
"REACTOME:R-HSA-9918454",
"REACTOME:R-MMU-2453902",
"REACTOME:R-MMU-382556"
] | 8 | [
"7e7i",
"7e7o",
"7e7q",
"7lkp",
"7lkz",
"7m1p",
"7m1q",
"8f5b"
] | 8 | [
"PUB00072118",
"PUB00072119",
"PUB00072120",
"PUB00072552"
] | [
"22735453",
"8002831",
"1866151",
"11441126"
] | [
"ABCA4 is an N-retinylidene-phosphatidylethanolamine and phosphatidylethanolamine importer.",
"Stargardt's macular dystrophy.",
"Delayed rod dark adaptation in patients with Stargardt's disease.",
"The human ATP-binding cassette (ABC) transporter superfamily."
] | [
2012,
1994,
1991,
2001
] | 4 | [
"IPR026082"
] | [] | 1 | 0 | 1 | [
"Amniota"
] | [
228
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
1,
4
] | 3 | true | Family | Retinal-specific ATP-binding cassette transporter | Retinal-specific ATP-binding cassette transporter | ABCA4/ABCR | 3 |
IPR005952 | 5,952 | Phosphoglycerate mutase 1 | Phosphogly_mut1 | Family | 24,790 | false | false | Most members of this family are phosphoglycerate mutases ( ) [ ]. This enzyme interconverts 2-phosphoglycerate and 3-phosphoglycerate. 2-phospho-D-glycerate + 2,3-diphosphoglycerate = 3-phospho-D-glycerate + 2,3-diphosphoglycerate. The enzyme is transiently phosphorylated on an active site histidine by 2,3-diphosphogly... | [
"GO:0016868",
"GO:0006096"
] | [
"intramolecular phosphotransferase activity",
"glycolytic process"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"HAMAP",
"PANTHER",
"NCBIFAM"
] | [
"MF_01039",
"PTHR11931",
"TIGR01258"
] | [
"PGAM_GpmA",
"",
"pgm_1"
] | [
19332,
24725,
19986
] | 3 | [
"EC",
"GP",
"GP",
"GP",
"GP",
"GP",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACT... | [
"5.4.2.11",
"GenProp0691",
"GenProp1306",
"GenProp1407",
"GenProp1599",
"GenProp1612",
"PWY-1622",
"PWY-5484",
"PWY-8004",
"PWY-8404",
"R-BTA-6798695",
"R-BTA-70171",
"R-BTA-70263",
"R-DDI-6798695",
"R-DDI-70171",
"R-DDI-70263",
"R-GGA-352875",
"R-GGA-352882",
"R-GGA-6798695",
... | [
"EC:5.4.2.11",
"GP:GenProp0691",
"GP:GenProp1306",
"GP:GenProp1407",
"GP:GenProp1599",
"GP:GenProp1612",
"METACYC:PWY-1622",
"METACYC:PWY-5484",
"METACYC:PWY-8004",
"METACYC:PWY-8404",
"REACTOME:R-BTA-6798695",
"REACTOME:R-BTA-70171",
"REACTOME:R-BTA-70263",
"REACTOME:R-DDI-6798695",
"RE... | 33 | [
"1bq3",
"1bq4",
"1e58",
"1e59",
"1fzt",
"1qhf",
"1rii",
"1t8p",
"1xq9",
"1yfk",
"1yjx",
"2a9j",
"2f90",
"2h4x",
"2h4z",
"2h52",
"2hhj",
"3d8h",
"3ezn",
"3fdz",
"3gp3",
"3gp5",
"3gw8",
"3kkk",
"3lnt",
"3nfy",
"3pgm",
"4emb",
"4eo9",
"4gpi",
"4gpz",
"4odi"... | 64 | [
"PUB00067071",
"PUB00103832"
] | [
"23653202",
"21045285"
] | [
"Tyr26 phosphorylation of PGAM1 provides a metabolic advantage to tumours by stabilizing the active conformation.",
"Unliganded structure of human bisphosphoglycerate mutase reveals side-chain movements induced by ligand binding."
] | [
2013,
2010
] | 2 | [
"IPR013078"
] | [] | 1 | 0 | 1 | [
"Archaea",
"Bacteria",
"Eukaryota",
"Mimivirus LCMiAC02",
"unclassified sequences"
] | [
154,
17370,
6873,
1,
392
] | 5 | [
"Arabidopsis thaliana",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)",
... | [
6,
4,
12,
1,
20,
10,
6,
9,
3,
1,
24
] | 11 | true | Family | Phosphoglycerate mutase 1 | Phosphoglycerate mutase 1 | Phosphogly_mut1 | 4 |
IPR005953 | 5,953 | ATP synthase, F0 complex, subunit C, bacterial/chloroplast | ATP_synth_csu_bac/chlpt | Family | 32,541 | false | false | Transmembrane ATPases are membrane-bound enzyme complexes/ion transporters that use ATP hydrolysis to drive the transport of protons across a membrane. Some transmembrane ATPases also work in reverse, harnessing the energy from a proton gradient, using the flux of ions across the membrane via the ATPase proton channel ... | [
"GO:0015078",
"GO:0015986",
"GO:0045259"
] | [
"proton transmembrane transporter activity",
"proton motive force-driven ATP synthesis",
"proton-transporting ATP synthase complex"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"NCBIFAM"
] | [
"TIGR01260"
] | [
"ATP_synt_c"
] | [
32541
] | 1 | [
"GP"
] | [
"GenProp0128"
] | [
"GP:GenProp0128"
] | 1 | [
"1a91",
"1aty",
"1c0v",
"1c17",
"1c99",
"1ijp",
"1l6t",
"1qo1",
"1wu0",
"1yce",
"2w5j",
"2wgm",
"2wie",
"2x2v",
"2xqs",
"2xqt",
"2xqu",
"3v3c",
"3zk1",
"3zk2",
"3zo6",
"4bem",
"4cbj",
"4cbk",
"4mjn",
"4utq",
"4v1f",
"4v1g",
"4v1h",
"5t4o",
"5t4p",
"5t4q"... | 136 | [
"PUB00009752",
"PUB00020603",
"PUB00020604",
"PUB00020632",
"PUB00068786",
"PUB00068787",
"PUB00068788",
"PUB00068789"
] | [
"11309608",
"15473999",
"15078220",
"14630314",
"20450191",
"18937357",
"1385979",
"9741106"
] | [
"Resolution of distinct rotational substeps by submillisecond kinetic analysis of F1-ATPase.",
"The evolution of A-, F-, and V-type ATP synthases and ATPases: reversals in function and changes in the H+/ATP coupling ratio.",
"Mechanisms of ATPases--a multi-disciplinary approach.",
"Mechanics of coupling proto... | [
2001,
2004,
2004,
2003,
2010,
2008,
1992,
1998
] | 8 | [
"IPR000454"
] | [
"IPR017708"
] | 1 | 1 | 0 | [
"Bacteria",
"Eukaryota",
"Stenosarchaea group",
"unclassified sequences"
] | [
18555,
13618,
26,
342
] | 4 | [
"Arabidopsis thaliana",
"Escherichia coli (strain K12)",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
4,
1,
2,
2
] | 4 | true | Family | ATP synthase, F0 complex, subunit C, bacterial/chloroplast | ATP synthase, F0 complex, subunit C, bacterial/chloroplast | ATP_synth_csu_bac/chlpt | 5 |
IPR005954 | 5,954 | Histidine biosynthesis bifunctional protein, N-terminal histidinol-phosphatase domain | HisB_N | Domain | 5,536 | false | false | This entry describes a histidinol phosphatase domain. This domain occurs in Histidine biosynthesis bifunctional protein HisB at the N-terminal region, followed by an imidazoleglycerol-phosphate dehydratase domain ( ). These enzymatic domains catalyse the ninth and seventh steps, respectively, of histidine biosynthesis ... | [
"GO:0004401",
"GO:0004424",
"GO:0000105",
"GO:0005737"
] | [
"histidinol-phosphatase activity",
"imidazoleglycerol-phosphate dehydratase activity",
"L-histidine biosynthetic process",
"cytoplasm"
] | [
"molecular_function",
"molecular_function",
"biological_process",
"cellular_component"
] | 4 | [
"NCBIFAM"
] | [
"TIGR01261"
] | [
"hisB_Nterm"
] | [
5536
] | 1 | [
"EC",
"EC",
"GP"
] | [
"3.1.3.15",
"4.2.1.19",
"GenProp0109"
] | [
"EC:3.1.3.15",
"EC:4.2.1.19",
"GP:GenProp0109"
] | 3 | [
"2fpr",
"2fps",
"2fpu",
"2fpw",
"2fpx"
] | 5 | [
"PUB00040771"
] | [
"16966333"
] | [
"Structural snapshots of Escherichia coli histidinol phosphate phosphatase along the reaction pathway."
] | [
2006
] | 1 | [
"IPR006543"
] | [] | 1 | 0 | 1 | [
"Bacteria",
"Opisthokonta",
"metagenomes"
] | [
5490,
7,
39
] | 3 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Domain | Histidine biosynthesis bifunctional protein, N-terminal histidinol-phosphatase domain | Histidine biosynthesis bifunctional protein, N-terminal histidinol-phosphatase domain | HisB_N | 5 |
IPR005955 | 5,955 | Glutathione S-transferases, class Zeta | GST_Zeta | Family | 11,982 | false | false | GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, therapeutic drugs, environmental toxins, and products of oxidative stress. The GST fold contains an N-termin... | [
"GO:0003824",
"GO:0009072",
"GO:0005737"
] | [
"catalytic activity",
"aromatic amino acid metabolic process",
"cytoplasm"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"NCBIFAM"
] | [
"TIGR01262"
] | [
"maiA"
] | [
11982
] | 1 | [
"EC",
"EC",
"GP",
"GP",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"2.5.1.18",
"5.2.1.2",
"GenProp0139",
"GenProp1375",
"PWY-4061",
"PWY-6842",
"PWY-7112",
"PWY-7533",
"R-CEL-156590",
"R-CEL-204174",
"R-CEL-8963684",
"R-DDI-156590",
"R-DDI-204174",
"R-DDI-8963684",
"R-DME-156590",
"R-DME-204174",
"R-DME-8963684",
"R-HSA-156590",
"R-HSA-204174",
... | [
"EC:2.5.1.18",
"EC:5.2.1.2",
"GP:GenProp0139",
"GP:GenProp1375",
"METACYC:PWY-4061",
"METACYC:PWY-6842",
"METACYC:PWY-7112",
"METACYC:PWY-7533",
"REACTOME:R-CEL-156590",
"REACTOME:R-CEL-204174",
"REACTOME:R-CEL-8963684",
"REACTOME:R-DDI-156590",
"REACTOME:R-DDI-204174",
"REACTOME:R-DDI-896... | 26 | [
"1e6b",
"1fw1",
"2cz2",
"2cz3",
"2jl4",
"2v6k",
"3lg6",
"3n5o",
"3niv",
"4igj",
"4kae",
"4kdy",
"4px1",
"4pxo",
"6jwk",
"8e8p"
] | 16 | [
"PUB00024446",
"PUB00083280",
"PUB00083281",
"PUB00083282",
"PUB00083283",
"PUB00083285"
] | [
"11352584",
"15607001",
"15069639",
"12052898",
"9396740",
"9815194"
] | [
"The structure of a zeta class glutathione S-transferase from Arabidopsis thaliana: characterisation of a GST with novel active-site architecture and a putative role in tyrosine catabolism.",
"Analysis of the glutathione S-transferase (GST) gene family.",
"Organisation and structural evolution of the rice gluta... | [
2001,
2004,
2004,
2002,
1997,
1998
] | 6 | [
"IPR040079"
] | [] | 1 | 0 | 1 | [
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
7207,
4732,
43
] | 3 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
11,
3,
3,
2,
7,
4,
12,
5,
8
] | 9 | true | Family | Glutathione S-transferases, class Zeta | Glutathione S-transferases, class Zeta | GST_Zeta | 6 |
IPR005956 | 5,956 | 4-hydroxyphenylpyruvate dioxygenase | 4OHPhenylPyrv_dOase | Family | 18,161 | false | false | 4-hydroxyphenylpyruvate dioxygenase ( ) oxidises 4-hydroxyphenylpyruvate, a tyrosine and phenylalanine catabolite, to homogentisate. Homogentisate can undergo a further non-enzymatic oxidation and polymerisation into brown pigments that protect some bacterial species from light. A similar process occurs spontaneously i... | [
"GO:0003868",
"GO:0016701",
"GO:0009072"
] | [
"4-hydroxyphenylpyruvate dioxygenase activity",
"oxidoreductase activity, acting on single donors with incorporation of molecular oxygen",
"aromatic amino acid metabolic process"
] | [
"molecular_function",
"molecular_function",
"biological_process"
] | 3 | [
"PIRSF",
"PANTHER",
"NCBIFAM"
] | [
"PIRSF009283",
"PTHR11959",
"TIGR01263"
] | [
"HPP_dOase",
"",
"4HPPD"
] | [
15744,
18128,
15280
] | 3 | [
"EC",
"GP",
"GP",
"GP",
"METACYC",
"METACYC",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"1.13.11.27",
"GenProp0139",
"GenProp1337",
"GenProp1375",
"PWY-1422",
"PWY-1581",
"PWY-6318",
"R-BTA-8963684",
"R-CEL-8963684",
"R-DDI-2142789",
"R-DDI-8963684",
"R-HSA-2142789",
"R-HSA-8963684",
"R-MMU-2142789",
"R-MMU-8963684",
"R-RNO-2142789",
"R-RNO-8963684"
] | [
"EC:1.13.11.27",
"GP:GenProp0139",
"GP:GenProp1337",
"GP:GenProp1375",
"METACYC:PWY-1422",
"METACYC:PWY-1581",
"METACYC:PWY-6318",
"REACTOME:R-BTA-8963684",
"REACTOME:R-CEL-8963684",
"REACTOME:R-DDI-2142789",
"REACTOME:R-DDI-8963684",
"REACTOME:R-HSA-2142789",
"REACTOME:R-HSA-8963684",
"RE... | 17 | [
"1cjx",
"1sp8",
"1sp9",
"1sqd",
"1sqi",
"1t47",
"1tfz",
"1tg5",
"2r5v",
"3isq",
"3zgj",
"5ec3",
"5xgk",
"5ywg",
"5ywh",
"5ywi",
"5ywk",
"5yy6",
"5yy7",
"6isd",
"6j63",
"6jx9",
"6lgt",
"6m6d",
"7cjk",
"7cqr",
"7cqs",
"7e0x",
"7ezq",
"7v6x",
"7vc8",
"7vo8"... | 128 | [
"PUB00007915"
] | [
"8000039"
] | [
"Homogentisic acid and structurally related compounds as intermediates in plasma soluble melanin formation and in tissue toxicities."
] | [
1994
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Methanobacteriati",
"unclassified sequences"
] | [
11660,
6361,
24,
116
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
6,
2,
8,
2,
3,
4,
1,
4,
5,
8
] | 10 | true | Family | 4-hydroxyphenylpyruvate dioxygenase | 4-hydroxyphenylpyruvate dioxygenase | 4OHPhenylPyrv_dOase | 3 |
IPR005957 | 5,957 | Tyrosine aminotransferase | Tyrosine_aminoTrfase | Family | 1,884 | false | false | This entry describes tyrosine aminotransferase ( ) as found in animals and Trypanosoma cruzi (Euglenozoa). It is the first enzyme of a pathway of tyrosine degradation via homogentisate. L-tyrosine + 2-oxoglutarate = 4-hydroxyphenylpyruvate + L-glutamate. | [
"GO:0004838",
"GO:0030170",
"GO:0009072"
] | [
"L-tyrosine-2-oxoglutarate transaminase activity",
"pyridoxal phosphate binding",
"aromatic amino acid metabolic process"
] | [
"molecular_function",
"molecular_function",
"biological_process"
] | 3 | [
"NCBIFAM"
] | [
"TIGR01264"
] | [
"tyr_amTase_E"
] | [
1884
] | 1 | [
"EC",
"GP",
"GP",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"2.6.1.5",
"GenProp0139",
"GenProp1375",
"R-BTA-8963684",
"R-CEL-8963684",
"R-DDI-8963684",
"R-HSA-8963684",
"R-MMU-8963684",
"R-RNO-8963684"
] | [
"EC:2.6.1.5",
"GP:GenProp0139",
"GP:GenProp1375",
"REACTOME:R-BTA-8963684",
"REACTOME:R-CEL-8963684",
"REACTOME:R-DDI-8963684",
"REACTOME:R-HSA-8963684",
"REACTOME:R-MMU-8963684",
"REACTOME:R-RNO-8963684"
] | 9 | [
"1bw0",
"3dyd",
"3pdx"
] | 3 | [] | [] | [] | [] | 0 | [
"IPR005958"
] | [] | 1 | 0 | 1 | [
"Eukaryota"
] | [
1884
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
2,
1,
3,
2,
3
] | 6 | true | Family | Tyrosine aminotransferase | Tyrosine aminotransferase | Tyrosine_aminoTrfase | 2 |
IPR005958 | 5,958 | Tyrosine/nicotianamine aminotransferase | TyrNic_aminoTrfase | Family | 5,353 | false | false | This subfamily of pyridoxal phosphate-dependent enzymes includes known examples of both tyrosine aminotransferase from animals and nicotianamine aminotransferase from barley. | [
"GO:0008483",
"GO:0030170",
"GO:0006520"
] | [
"transaminase activity",
"pyridoxal phosphate binding",
"amino acid metabolic process"
] | [
"molecular_function",
"molecular_function",
"biological_process"
] | 3 | [
"PIRSF",
"NCBIFAM"
] | [
"PIRSF000517",
"TIGR01265"
] | [
"Tyr_transaminase",
"tyr_nico_aTase"
] | [
4707,
5216
] | 2 | [
"EC",
"GP",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"2.6.1",
"GenProp1375",
"R-BTA-8963684",
"R-CEL-8963684",
"R-DDI-8963684",
"R-HSA-8963684",
"R-MMU-8963684",
"R-RNO-8963684"
] | [
"EC:2.6.1",
"GP:GenProp1375",
"REACTOME:R-BTA-8963684",
"REACTOME:R-CEL-8963684",
"REACTOME:R-DDI-8963684",
"REACTOME:R-HSA-8963684",
"REACTOME:R-MMU-8963684",
"REACTOME:R-RNO-8963684"
] | 8 | [
"1bw0",
"3dyd",
"3pdx",
"4ix8"
] | 4 | [] | [] | [] | [] | 0 | [] | [
"IPR005957"
] | 0 | 1 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"ecological metagenomes"
] | [
25,
42,
5283,
3
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
30,
1,
2,
1,
3,
2,
21,
3,
27
] | 9 | true | Family | Tyrosine/nicotianamine aminotransferase | Tyrosine/nicotianamine aminotransferase | TyrNic_aminoTrfase | 7 |
IPR005959 | 5,959 | Fumarylacetoacetase | Fumarylacetoacetase | Family | 14,098 | false | false | Fumarylacetoacetase ( ; also known as fumarylacetoacetate hydrolase or FAH) catalyses the hydrolytic cleavage of a carbon-carbon bond in fumarylacetoacetate to yield fumarate and acetoacetate as the final step in phenylalanine and tyrosine degradation [ , ]. This is an essential metabolic function in humans, the lack o... | [
"GO:0004334",
"GO:0009072"
] | [
"fumarylacetoacetase activity",
"aromatic amino acid metabolic process"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PANTHER",
"NCBIFAM"
] | [
"PTHR43069",
"TIGR01266"
] | [
"",
"fum_ac_acetase"
] | [
14091,
11421
] | 2 | [
"EC",
"GP",
"GP",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"3.7.1.2",
"GenProp0139",
"GenProp1375",
"R-CEL-8963684",
"R-DDI-8963684",
"R-HSA-8963684",
"R-MMU-8963684",
"R-RNO-8963684"
] | [
"EC:3.7.1.2",
"GP:GenProp0139",
"GP:GenProp1375",
"REACTOME:R-CEL-8963684",
"REACTOME:R-DDI-8963684",
"REACTOME:R-HSA-8963684",
"REACTOME:R-MMU-8963684",
"REACTOME:R-RNO-8963684"
] | 8 | [
"1hyo",
"1qcn",
"1qco",
"1qqj",
"2hzy",
"4qku",
"5ti1"
] | 7 | [
"PUB00002007",
"PUB00022554",
"PUB00025833",
"PUB00035625",
"PUB00099555",
"PUB00099556",
"PUB00099624"
] | [
"9101289",
"10508789",
"11154690",
"16602095",
"19028908",
"22046314",
"27097641"
] | [
"Mutations in the fumarylacetoacetate hydrolase gene causing hereditary tyrosinemia type I: overview.",
"Crystal structure and mechanism of a carbon-carbon bond hydrolase.",
"Mechanistic inferences from the crystal structure of fumarylacetoacetate hydrolase with a bound phosphorus-based inhibitor.",
"The gene... | [
1997,
1999,
2001,
2006,
2009,
2011,
2016
] | 7 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Methanobacteriati",
"metagenomes"
] | [
7510,
6532,
12,
44
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
5,
7,
3,
1,
7,
2,
1,
2,
3,
15
] | 10 | true | Family | Fumarylacetoacetase | Fumarylacetoacetase | Fumarylacetoacetase | 3 |
IPR005960 | 5,960 | Phenylalanine-4-hydroxylase, monomeric form | Phe-4-hydroxylase_mono | Family | 4,083 | false | false | This entry represents the small, monomeric form of phenylalanine-4-hydroxylase (PAH; ), as found in a certain Gram-negative bacteria. The enzyme is biopterin and metal dependent, and acts to irreversibly convert phenylalanine to tyrosine, the rate-limiting step in phenylalanine catabolism in some systems: L-phenylalani... | [
"GO:0004505",
"GO:0006559"
] | [
"phenylalanine 4-monooxygenase activity",
"L-phenylalanine catabolic process"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"NCBIFAM",
"CDD"
] | [
"TIGR01267",
"cd03348"
] | [
"Phe4hydrox_mono",
"pro_PheOH"
] | [
4068,
3684
] | 2 | [
"EC",
"METACYC",
"METACYC"
] | [
"1.14.16.1",
"PWY-6134",
"PWY-7158"
] | [
"EC:1.14.16.1",
"METACYC:PWY-6134",
"METACYC:PWY-7158"
] | 3 | [
"1ltu",
"1ltv",
"1ltz",
"2v27",
"2v28",
"3tcy",
"3tk2",
"3tk4",
"4bpt",
"4esm",
"4etl",
"4jpx",
"4jpy",
"4q3w",
"4q3x",
"4q3y",
"4q3z"
] | 17 | [
"PUB00035859"
] | [
"17537732"
] | [
"Structure of phenylalanine hydroxylase from Colwellia psychrerythraea 34H, a monomeric cold active enzyme with local flexibility around the active site and high overall stability."
] | [
2007
] | 1 | [
"IPR001273"
] | [] | 1 | 0 | 1 | [
"Bacteria",
"Diploscapter pachys",
"metagenomes"
] | [
4068,
1,
14
] | 3 | [] | [] | 0 | true | Family | Phenylalanine-4-hydroxylase, monomeric form | Phenylalanine-4-hydroxylase, monomeric form | Phe-4-hydroxylase_mono | 3 |
IPR005962 | 5,962 | Tyrosine 3-monooxygenase | Tyr_3_mOase | Family | 1,414 | false | false | Tyrosine 3-monooxygenase ( ), is a member of the family of tetrameric, biopterin-dependent aromatic amino acid hydroxylases found in metazoans. It is closely related to tetrameric phenylalanine-4-hydroxylase and tryptophan 5-monooxygenase, and more distantly related to the monomeric phenylalanine-4-hydroxylase found in... | [
"GO:0004511",
"GO:0042423"
] | [
"tyrosine 3-monooxygenase activity",
"catecholamine biosynthetic process"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"NCBIFAM"
] | [
"TIGR01269"
] | [
"Tyr_3_monoox"
] | [
1414
] | 1 | [
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"1.14.16.2",
"PWY-3581",
"PWY-5049",
"PWY-5394",
"PWY-6133",
"R-DME-209905",
"R-HSA-209905",
"R-MMU-209905",
"R-RNO-209905"
] | [
"EC:1.14.16.2",
"METACYC:PWY-3581",
"METACYC:PWY-5049",
"METACYC:PWY-5394",
"METACYC:PWY-6133",
"REACTOME:R-DME-209905",
"REACTOME:R-HSA-209905",
"REACTOME:R-MMU-209905",
"REACTOME:R-RNO-209905"
] | 9 | [
"6zvp",
"7a2g"
] | 2 | [] | [] | [] | [] | 0 | [
"IPR019773"
] | [] | 1 | 0 | 1 | [
"Eukaryota"
] | [
1414
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
2,
1,
2,
8
] | 5 | true | Family | Tyrosine 3-monooxygenase | Tyrosine 3-monooxygenase | Tyr_3_mOase | 1 |
IPR005963 | 5,963 | Tryptophan 5-monooxygenase | Trp_5_mOase | Family | 2,336 | false | false | Tryptophan 5-monooxygenase ( ) is a member of the family of tetrameric, biopterin-dependent aromatic amino acid hydroxylases found in metazoans. It is closely related to tetrameric phenylalanine-4-hydroxylase and tyrosine 3-monooxygenase, and more distantly related to the monomeric phenylalanine-4-hydroxylase found in ... | [
"GO:0004510",
"GO:0042427"
] | [
"tryptophan 5-monooxygenase activity",
"serotonin biosynthetic process"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"NCBIFAM"
] | [
"TIGR01270"
] | [
"Trp_5_monoox"
] | [
2336
] | 1 | [
"EC",
"GP",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"1.14.16.4",
"GenProp1695",
"PWY-6030",
"R-HSA-209931",
"R-HSA-9031628",
"R-MMU-209931",
"R-RNO-209931"
] | [
"EC:1.14.16.4",
"GP:GenProp1695",
"METACYC:PWY-6030",
"REACTOME:R-HSA-209931",
"REACTOME:R-HSA-9031628",
"REACTOME:R-MMU-209931",
"REACTOME:R-RNO-209931"
] | 7 | [
"5l01",
"7wiy"
] | 2 | [
"PUB00033171"
] | [
"11472242"
] | [
"A structural approach into human tryptophan hydroxylase and its implications for the regulation of serotonin biosynthesis."
] | [
2001
] | 1 | [
"IPR019773"
] | [] | 1 | 0 | 1 | [
"Bilateria"
] | [
2336
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
5,
1,
5,
3,
5
] | 6 | true | Family | Tryptophan 5-monooxygenase | Tryptophan 5-monooxygenase | Trp_5_mOase | 9 |
IPR005964 | 5,964 | Bacterial glucose/galactose transporter | Glc/Gal_transptr_bac | Family | 5,750 | false | false | This model describes the glucose/galactose transporter in bacteria. Putative transporters in bacterial species have been isolated by functional complementation, which restored its functional activity. These two transporters are members of the major facilitator superfamily, FHS, in which they represent a previously unde... | [
"GO:0005354",
"GO:0055056",
"GO:0015757",
"GO:1904659",
"GO:0016020"
] | [
"galactose transmembrane transporter activity",
"D-glucose transmembrane transporter activity",
"galactose transmembrane transport",
"D-glucose transmembrane transport",
"membrane"
] | [
"molecular_function",
"molecular_function",
"biological_process",
"biological_process",
"cellular_component"
] | 5 | [
"NCBIFAM"
] | [
"TIGR01272"
] | [
"gluP"
] | [
5750
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00007917"
] | [
"9168605"
] | [
"Brucella abortus strain 2308 putative glucose and galactose transporter gene: cloning and characterization."
] | [
1997
] | 1 | [
"IPR011701"
] | [] | 1 | 0 | 1 | [
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
5712,
4,
34
] | 3 | [] | [] | 0 | true | Family | Bacterial glucose/galactose transporter | Bacterial glucose/galactose transporter | Glc/Gal_transptr_bac | 2 |
IPR005965 | 5,965 | 1-aminocyclopropane-1-carboxylate deaminase | ACP_carboxylate_deaminase | Family | 3,393 | false | false | 1-aminocyclopropane-1-carboxylate deaminase ( ) is a pyridoxal phosphate-dependent enzyme which catalyses a cyclopropane ring-opening reaction, the irreversible conversion of 1-aminocyclopropane-1-carboxylate (ACC) to ammonia and alpha-ketobutyrate [ ]. In plants, the latter is a precursor of the ripening hormone ethyl... | [
"GO:0008660",
"GO:0030170",
"GO:0009310"
] | [
"1-aminocyclopropane-1-carboxylate deaminase activity",
"pyridoxal phosphate binding",
"amine catabolic process"
] | [
"molecular_function",
"molecular_function",
"biological_process"
] | 3 | [
"NCBIFAM"
] | [
"TIGR01274"
] | [
"ACC_deam"
] | [
3393
] | 1 | [
"EC"
] | [
"3.5.99.7"
] | [
"EC:3.5.99.7"
] | 1 | [
"1f2d",
"1j0c",
"1j0d",
"1j0e",
"1rqx",
"1tyz",
"1tz2",
"1tzj",
"1tzk",
"1tzm"
] | 10 | [
"PUB00015575",
"PUB00063667",
"PUB00063668",
"PUB00063669"
] | [
"9604000",
"21244019",
"22805914",
"21523387"
] | [
"Properties, sequence, and synthesis in Escherichia coli of 1-aminocyclopropane-1-carboxylate deaminase from Hansenula saturnus.",
"Mechanistic studies of 1-aminocyclopropane-1-carboxylate deaminase: characterization of an unusual pyridoxal 5'-phosphate-dependent reaction.",
"Plant growth-promoting rhizobacteri... | [
1998,
2011,
2012,
2011
] | 4 | [
"IPR027278"
] | [
"IPR020601"
] | 1 | 1 | 0 | [
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
2530,
840,
23
] | 3 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)",
"Zea mays"
] | [
1,
1,
1
] | 3 | true | Family | 1-aminocyclopropane-1-carboxylate deaminase | 1-aminocyclopropane-1-carboxylate deaminase | ACP_carboxylate_deaminase | 8 |
IPR005966 | 5,966 | D-cysteine desulfhydrase | D-Cys_desShydrase | Family | 4,170 | false | false | This entry represents a family of pyridoxal phosphate-dependent enzymes closely related to (and often designated as putative examples of) 1-aminocyclopropane-1-carboxylate deaminase. Members of this family include D-cysteine desulfhydrase ( ) , 1-aminocyclopropane-1-carboxylate deaminase ( ), and L-cysteate sulfo-lyase... | [
"GO:0003824"
] | [
"catalytic activity"
] | [
"molecular_function"
] | 1 | [
"NCBIFAM"
] | [
"TIGR01275"
] | [
"ACC_deam_rel"
] | [
4170
] | 1 | [
"EC"
] | [
"4.4.1.15"
] | [
"EC:4.4.1.15"
] | 1 | [
"1j0a",
"1j0b",
"4d8t",
"4d8u",
"4d8w",
"4d92",
"4d96",
"4d97",
"4d99",
"4d9b",
"4d9c",
"4d9e",
"4d9f",
"7ysk",
"7ysl"
] | 15 | [
"PUB00063667",
"PUB00063668",
"PUB00063669",
"PUB00063670",
"PUB00063671",
"PUB00063672",
"PUB00063673"
] | [
"21244019",
"22805914",
"21523387",
"15720402",
"3132906",
"3908101",
"16302849"
] | [
"Mechanistic studies of 1-aminocyclopropane-1-carboxylate deaminase: characterization of an unusual pyridoxal 5'-phosphate-dependent reaction.",
"Plant growth-promoting rhizobacteria (PGPR): emergence in agriculture.",
"Metagenomic analysis of the 1-aminocyclopropane-1-carboxylate deaminase gene (acdS) operon o... | [
2011,
2012,
2011,
2005,
1988,
1985,
2006
] | 7 | [
"IPR027278"
] | [
"IPR023702"
] | 1 | 1 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
17,
3438,
688,
27
] | 4 | [
"Arabidopsis thaliana",
"Escherichia coli (strain K12)",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
4,
1,
2,
11
] | 4 | true | Family | D-cysteine desulfhydrase | D-cysteine desulfhydrase | D-Cys_desShydrase | 1 |
IPR005968 | 5,968 | Thiamine ABC transporter, ATP-binding protein ThiQ | Thiamine_ABC_ThiQ | Family | 2,459 | false | false | This entry represents the energy-transducing ATPase subunit ThiQ of the ThiBPQ thiamine (and thiamine pyrophosphate) ABC transporter in several proteobacteria. This protein is found so far only in proteobacteria, and is found in complete genomes only if the ThiB and ThiP subunits are also found. | [
"GO:0005524",
"GO:0042626",
"GO:0071934",
"GO:0016020"
] | [
"ATP binding",
"ATPase-coupled transmembrane transporter activity",
"thiamine transmembrane transport",
"membrane"
] | [
"molecular_function",
"molecular_function",
"biological_process",
"cellular_component"
] | 4 | [
"NCBIFAM"
] | [
"TIGR01277"
] | [
"thiQ"
] | [
2459
] | 1 | [
"EC",
"GP"
] | [
"7.6.2.15",
"GenProp0252"
] | [
"EC:7.6.2.15",
"GP:GenProp0252"
] | 2 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Rhodnius prolixus",
"hydrothermal vent metagenome"
] | [
2457,
1,
1
] | 3 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Thiamine ABC transporter, ATP-binding protein ThiQ | Thiamine ABC transporter, ATP-binding protein ThiQ | Thiamine_ABC_ThiQ | 2 |
IPR005970 | 5,970 | Light-independent protochlorophyllide reductase, N subunit | Protochl_reductN | Family | 2,405 | false | false | Synonym: dark protochlorophyllide reductase Protochlorophyllide reductase catalyzes the reductive formation of chlorophyllide from protochlorophyllide during biosynthesis of chlorophylls and bacteriochlorophylls. The light-independent (dark) form of protochlorophyllide reductase plays a key role in the ability of gymno... | [
"GO:0016730",
"GO:0015995",
"GO:0019685"
] | [
"oxidoreductase activity, acting on iron-sulfur proteins as donors",
"chlorophyll biosynthetic process",
"photosynthesis, dark reaction"
] | [
"molecular_function",
"biological_process",
"biological_process"
] | 3 | [
"HAMAP",
"PIRSF",
"NCBIFAM"
] | [
"MF_00352",
"PIRSF000162",
"TIGR01279"
] | [
"ChlN_BchN",
"P_chlorophyll_rd",
"DPOR_bchN"
] | [
2254,
2360,
2387
] | 3 | [
"EC",
"GP",
"METACYC",
"METACYC"
] | [
"1.3.7.7",
"GenProp1004",
"PWY-5531",
"PWY-7159"
] | [
"EC:1.3.7.7",
"GP:GenProp1004",
"METACYC:PWY-5531",
"METACYC:PWY-7159"
] | 4 | [
"2xdq",
"2ynm",
"3aek",
"3aeq",
"3aer",
"3aes",
"3aet",
"3aeu",
"8vqh",
"8vqi",
"8vqj",
"9buo",
"9e7h",
"9efu"
] | 14 | [
"PUB00007918"
] | [
"10811655"
] | [
"Reconstitution of light-independent protochlorophyllide reductase from purified bchl and BchN-BchB subunits. In vitro confirmation of nitrogenase-like features of a bacteriochlorophyll biosynthesis enzyme."
] | [
2000
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"freshwater sediment metagenome"
] | [
1055,
1349,
1
] | 3 | [] | [] | 0 | true | Family | Light-independent protochlorophyllide reductase, N subunit | Light-independent protochlorophyllide reductase, N subunit | Protochl_reductN | 3 |
IPR005971 | 5,971 | Light-independent protochlorophyllide reductase, iron-sulphur ATP-binding protein | Protochlorophyllide_ATP-bd | Family | 2,474 | false | false | Synonym: dark protochlorophyllide reductase Protochlorophyllide reductase catalyzes the reductive formation of chlorophyllide from protochlorophyllide during biosynthesis of chlorophylls and bacteriochlorophylls. Three genes, bchL, bchN and bchB, are involved in light-independent protochlorophyllide reduction in bacter... | [
"GO:0005524",
"GO:0016730",
"GO:0015995",
"GO:0019685"
] | [
"ATP binding",
"oxidoreductase activity, acting on iron-sulfur proteins as donors",
"chlorophyll biosynthetic process",
"photosynthesis, dark reaction"
] | [
"molecular_function",
"molecular_function",
"biological_process",
"biological_process"
] | 4 | [
"HAMAP",
"NCBIFAM"
] | [
"MF_00355",
"TIGR01281"
] | [
"ChlL_BchL",
"DPOR_bchL"
] | [
2435,
2474
] | 2 | [
"EC",
"GP",
"METACYC",
"METACYC"
] | [
"1.3.7.7",
"GenProp1004",
"PWY-5531",
"PWY-7159"
] | [
"EC:1.3.7.7",
"GP:GenProp1004",
"METACYC:PWY-5531",
"METACYC:PWY-7159"
] | 4 | [
"2ynm",
"3fwy",
"6uyk",
"8vqj",
"9buo"
] | 5 | [
"PUB00007918"
] | [
"10811655"
] | [
"Reconstitution of light-independent protochlorophyllide reductase from purified bchl and BchN-BchB subunits. In vitro confirmation of nitrogenase-like features of a bacteriochlorophyll biosynthesis enzyme."
] | [
2000
] | 1 | [
"IPR000392"
] | [] | 1 | 0 | 1 | [
"Bacteria",
"Eukaryota",
"freshwater sediment metagenome"
] | [
1074,
1399,
1
] | 3 | [] | [] | 0 | true | Family | Light-independent protochlorophyllide reductase, iron-sulphur ATP-binding protein | Light-independent protochlorophyllide reductase, iron-sulphur ATP-binding protein | Protochlorophyllide_ATP-bd | 1 |
IPR005972 | 5,972 | Nitrogenase molybdenum-iron protein alpha chain | Nase_Mo-Fe_asu | Family | 1,935 | false | false | The enzyme responsible for nitrogen fixation, the nitrogenase, shows a high degree of conservation of structure, function, and amino acid sequence across wide phylogenetic ranges. All known Mo-nitrogenases consist of two components, component I (also called dinitrogenase, or Fe-Mo protein), an alpha2beta2 tetramer enco... | [
"GO:0016163",
"GO:0009399",
"GO:0016612"
] | [
"nitrogenase activity",
"nitrogen fixation",
"molybdenum-iron nitrogenase complex"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"NCBIFAM",
"CDD"
] | [
"TIGR01282",
"cd01976"
] | [
"nifD",
"Nitrogenase_MoFe_alpha"
] | [
1930,
1602
] | 2 | [
"EC",
"GP"
] | [
"1.18.6.1",
"GenProp0633"
] | [
"EC:1.18.6.1",
"GP:GenProp0633"
] | 2 | [
"1fp4",
"1g20",
"1g21",
"1h1l",
"1l5h",
"1m1n",
"1m1y",
"1m34",
"1mio",
"1n2c",
"1qgu",
"1qh1",
"1qh8",
"2afh",
"2afi",
"2min",
"3k1a",
"3min",
"3u7q",
"4nd8",
"4tku",
"4tkv",
"4wes",
"4wn9",
"4wna",
"4wza",
"4wzb",
"4xpi",
"5bvg",
"5bvh",
"5cx1",
"5koh"... | 96 | [
"PUB00033167",
"PUB00033168",
"PUB00033169",
"PUB00033170",
"PUB00080687",
"PUB00080688"
] | [
"10903367",
"12823187",
"8226614",
"7876209",
"11913144",
"8286368"
] | [
"Molecular evolution of nitrogen fixation: the evolutionary history of the nifD, nifK, nifE, and nifN genes.",
"Nitrogenase gene diversity and microbial community structure: a cross-system comparison.",
"Nitrogenase metalloclusters: structures, organization, and synthesis.",
"Characteristics of NIFNE in Azoto... | [
2000,
2003,
1993,
1995,
2002,
1994
] | 6 | [
"IPR010143"
] | [] | 1 | 0 | 1 | [
"Bacteria",
"Methanomicrobia",
"metagenomes"
] | [
1856,
55,
24
] | 3 | [] | [] | 0 | true | Family | Nitrogenase molybdenum-iron protein alpha chain | Nitrogenase molybdenum-iron protein alpha chain | Nase_Mo-Fe_asu | 1 |
IPR005973 | 5,973 | Nitrogenase MoFe cofactor biosynthesis protein NifE | NifE | Family | 1,949 | false | false | This entry refers to the nitrogenase MoFe cofactor biosynthesis protein encoded by the gene nifE. The enzyme responsible for nitrogen fixation, the nitrogenase, shows a high degree of conservation of structure, function, and amino acid sequence across wide phylogenetic ranges. All known Mo-nitrogenases consist of two c... | [
"GO:0009399",
"GO:0065003"
] | [
"nitrogen fixation",
"protein-containing complex assembly"
] | [
"biological_process",
"biological_process"
] | 2 | [
"NCBIFAM"
] | [
"TIGR01283"
] | [
"nifE"
] | [
1949
] | 1 | [
"GP"
] | [
"GenProp0029"
] | [
"GP:GenProp0029"
] | 1 | [
"3pdi",
"9i0g",
"9i0h"
] | 3 | [
"PUB00033167",
"PUB00033168",
"PUB00033169",
"PUB00033170",
"PUB00080687",
"PUB00080688"
] | [
"10903367",
"12823187",
"8226614",
"7876209",
"11913144",
"8286368"
] | [
"Molecular evolution of nitrogen fixation: the evolutionary history of the nifD, nifK, nifE, and nifN genes.",
"Nitrogenase gene diversity and microbial community structure: a cross-system comparison.",
"Nitrogenase metalloclusters: structures, organization, and synthesis.",
"Characteristics of NIFNE in Azoto... | [
2000,
2003,
1993,
1995,
2002,
1994
] | 6 | [
"IPR049939"
] | [] | 1 | 0 | 1 | [
"Bacteria",
"Methanobacteriota",
"metagenomes"
] | [
1823,
100,
26
] | 3 | [] | [] | 0 | true | Family | Nitrogenase MoFe cofactor biosynthesis protein NifE | Nitrogenase MoFe cofactor biosynthesis protein NifE | NifE | 6 |
IPR005974 | 5,974 | Nitrogenase alpha chain | Nase_asu | Family | 347 | false | false | The enzyme responsible for nitrogen fixation, the nitrogenase, shows a high degree of conservation of structure, function, and amino acid sequence across wide phylogenetic ranges. All known Mo-nitrogenases consist of two components, component I (also called dinitrogenase, or Fe-Mo protein), an alpha2beta2 tetramer enco... | [
"GO:0016163",
"GO:0051536",
"GO:0009399"
] | [
"nitrogenase activity",
"iron-sulfur cluster binding",
"nitrogen fixation"
] | [
"molecular_function",
"molecular_function",
"biological_process"
] | 3 | [
"NCBIFAM"
] | [
"TIGR01284"
] | [
"alt_nitrog_alph"
] | [
347
] | 1 | [
"EC"
] | [
"1.18.6.1"
] | [
"EC:1.18.6.1"
] | 1 | [
"5n6y",
"6fea",
"7adr",
"7ady",
"7aiz",
"8boq",
"8oie",
"8pbb"
] | 8 | [] | [] | [] | [] | 0 | [
"IPR010143"
] | [
"IPR010142",
"IPR011290"
] | 1 | 2 | 0 | [
"Bacteria",
"Methanobacteriota",
"unclassified sequences"
] | [
262,
77,
8
] | 3 | [] | [] | 0 | true | Family | Nitrogenase alpha chain | Nitrogenase alpha chain | Nase_asu | 3 |
IPR005975 | 5,975 | Nitrogenase molybdenum-iron cofactor biosynthesis protein | Nase_Mo-Fe_CF | Family | 1,514 | false | false | The enzyme responsible for nitrogen fixation, the nitrogenase, shows a high degree of conservation of structure, function, and amino acid sequence across wide phylogenetic ranges. All known Mo-nitrogenases consist of two components, component I (also called dinitrogenase, or Fe-Mo protein), an alpha2beta2 tetramer enco... | [
"GO:0009399",
"GO:0065003"
] | [
"nitrogen fixation",
"protein-containing complex assembly"
] | [
"biological_process",
"biological_process"
] | 2 | [
"NCBIFAM",
"CDD"
] | [
"TIGR01285",
"cd01966"
] | [
"nifN",
"Nitrogenase_NifN_1"
] | [
1513,
1274
] | 2 | [
"GP"
] | [
"GenProp0029"
] | [
"GP:GenProp0029"
] | 1 | [
"3pdi",
"9i0g",
"9i0h"
] | 3 | [
"PUB00017659",
"PUB00033167",
"PUB00033168",
"PUB00033169",
"PUB00033170",
"PUB00080687",
"PUB00080688",
"PUB00081074",
"PUB00081075"
] | [
"7592933",
"10903367",
"12823187",
"8226614",
"7876209",
"11913144",
"8286368",
"15728375",
"16423898"
] | [
"Incorporation of iron and sulfur from NifB cofactor into the iron-molybdenum cofactor of dinitrogenase.",
"Molecular evolution of nitrogen fixation: the evolutionary history of the nifD, nifK, nifE, and nifN genes.",
"Nitrogenase gene diversity and microbial community structure: a cross-system comparison.",
... | [
1995,
2000,
2003,
1993,
1995,
2002,
1994,
2005,
2006
] | 9 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Methanobacteriaceae",
"metagenomes"
] | [
1488,
8,
18
] | 3 | [] | [] | 0 | true | Family | Nitrogenase molybdenum-iron cofactor biosynthesis protein | Nitrogenase molybdenum-iron cofactor biosynthesis protein | Nase_Mo-Fe_CF | 3 |
IPR005976 | 5,976 | Nitrogenase molybdenum-iron protein beta chain | Nase_Mo-Fe_CF_bsu | Family | 1,833 | false | false | The enzyme responsible for nitrogen fixation, the nitrogenase, shows a high degree of conservation of structure, function, and amino acid sequence across wide phylogenetic ranges. All known Mo-nitrogenases consist of two components, component I (also called dinitrogenase, or Fe-Mo protein), an alpha2beta2 tetramer enco... | [
"GO:0016163",
"GO:0009399",
"GO:0016612"
] | [
"nitrogenase activity",
"nitrogen fixation",
"molybdenum-iron nitrogenase complex"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"NCBIFAM"
] | [
"TIGR01286"
] | [
"nifK"
] | [
1833
] | 1 | [
"EC",
"GP"
] | [
"1.18.6.1",
"GenProp0633"
] | [
"EC:1.18.6.1",
"GP:GenProp0633"
] | 2 | [
"1fp4",
"1g20",
"1g21",
"1h1l",
"1l5h",
"1m1n",
"1m1y",
"1m34",
"1mio",
"1n2c",
"1qgu",
"1qh1",
"1qh8",
"2afh",
"2afi",
"2min",
"3k1a",
"3min",
"3u7q",
"4nd8",
"4tku",
"4tkv",
"4wes",
"4wn9",
"4wna",
"4wza",
"4wzb",
"4xpi",
"5bvg",
"5bvh",
"5cx1",
"5koh"... | 96 | [
"PUB00033167",
"PUB00033168",
"PUB00033169",
"PUB00033170",
"PUB00080687",
"PUB00080688"
] | [
"10903367",
"12823187",
"8226614",
"7876209",
"11913144",
"8286368"
] | [
"Molecular evolution of nitrogen fixation: the evolutionary history of the nifD, nifK, nifE, and nifN genes.",
"Nitrogenase gene diversity and microbial community structure: a cross-system comparison.",
"Nitrogenase metalloclusters: structures, organization, and synthesis.",
"Characteristics of NIFNE in Azoto... | [
2000,
2003,
1993,
1995,
2002,
1994
] | 6 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Methanomicrobia",
"metagenomes"
] | [
1766,
44,
23
] | 3 | [] | [] | 0 | true | Family | Nitrogenase molybdenum-iron protein beta chain | Nitrogenase molybdenum-iron protein beta chain | Nase_Mo-Fe_CF_bsu | 9 |
IPR005977 | 5,977 | Nitrogenase iron protein NifH | Nitrogenase_Fe_NifH | Family | 3,206 | false | false | This entry represents the nitrogenase iron protein (component II), which is encoded by nifH. The enzyme responsible for nitrogen fixation, the nitrogenase, shows a high degree of conservation of structure, function, and amino acid sequence across wide phylogenetic ranges. All known Mo-nitrogenases consist of two compon... | [
"GO:0016163",
"GO:0009399"
] | [
"nitrogenase activity",
"nitrogen fixation"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"HAMAP",
"NCBIFAM"
] | [
"MF_00533",
"TIGR01287"
] | [
"NifH",
"nifH"
] | [
2593,
3168
] | 2 | [
"EC",
"GP"
] | [
"1.18.6.1",
"GenProp0029"
] | [
"EC:1.18.6.1",
"GP:GenProp0029"
] | 2 | [
"1cp2",
"1de0",
"1fp6",
"1g1m",
"1g20",
"1g21",
"1g5p",
"1m1y",
"1m34",
"1n2c",
"1nip",
"1rw4",
"1xcp",
"1xd8",
"1xd9",
"1xdb",
"2afh",
"2afi",
"2c8v",
"2nip",
"4wza",
"4wzb",
"6n4j",
"6n4k",
"6n4l",
"6n4m",
"6nzj",
"6o0b",
"6q93",
"7qqa",
"7t4h",
"7tne"... | 66 | [
"PUB00033167",
"PUB00033168",
"PUB00033169",
"PUB00033170",
"PUB00080687",
"PUB00080688"
] | [
"10903367",
"12823187",
"8226614",
"7876209",
"11913144",
"8286368"
] | [
"Molecular evolution of nitrogen fixation: the evolutionary history of the nifD, nifK, nifE, and nifN genes.",
"Nitrogenase gene diversity and microbial community structure: a cross-system comparison.",
"Nitrogenase metalloclusters: structures, organization, and synthesis.",
"Characteristics of NIFNE in Azoto... | [
2000,
2003,
1993,
1995,
2002,
1994
] | 6 | [
"IPR000392"
] | [] | 1 | 0 | 1 | [
"Bacteria",
"Methanobacteriota",
"unclassified sequences"
] | [
2952,
218,
36
] | 3 | [] | [] | 0 | true | Family | Nitrogenase iron protein NifH | Nitrogenase iron protein NifH | Nitrogenase_Fe_NifH | 7 |
IPR005979 | 5,979 | Protochlorophyllide reductase | Prochl_reduct | Family | 2,108 | false | false | Protochlorophyllide (Pchlide) reductases act in chlorophyll biosynthesis. There are distinct enzymes that catalyze Pchlide reduction in light or dark conditions [ ]. This family contains the light-dependent, NADPH-dependent form of protochlorophyllide reductase ( ) which catalyses the reaction chlorophyllide A + NADP+ ... | [
"GO:0016630"
] | [
"protochlorophyllide reductase activity"
] | [
"molecular_function"
] | 1 | [
"PANTHER",
"NCBIFAM"
] | [
"PTHR44419",
"TIGR01289"
] | [
"",
"LPOR"
] | [
2082,
1702
] | 2 | [
"EC",
"GP"
] | [
"1.3.1.33",
"GenProp0144"
] | [
"EC:1.3.1.33",
"GP:GenProp0144"
] | 2 | [
"6l1g",
"6l1h",
"6r46",
"6r48",
"6rnv",
"6rnw",
"7jk9"
] | 7 | [
"PUB00080632"
] | [
"17028153"
] | [
"Differential operation of dual protochlorophyllide reductases for chlorophyll biosynthesis in response to environmental oxygen levels in the cyanobacterium Leptolyngbya boryana."
] | [
2006
] | 1 | [
"IPR002347"
] | [] | 1 | 0 | 1 | [
"Bacteria",
"Eukaryota"
] | [
385,
1723
] | 2 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
12,
3,
24
] | 3 | true | Family | Protochlorophyllide reductase | Protochlorophyllide reductase | Prochl_reduct | 2 |
IPR005980 | 5,980 | Nitrogenase cofactor biosynthesis protein NifB | Nase_CF_NifB | Family | 1,867 | false | false | NifB is a protein required for the biosynthesis of the iron-molybdenum (or iron-vanadium) cofactor used by the nitrogen-fixing enzyme nitrogenase. NifB belongs to the radical SAM family, and the FeMo cluster biosynthesis process requires S-adenosylmethionine [ , ]. | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"TIGR01290"
] | [
"nifB"
] | [
1867
] | 1 | [
"GP"
] | [
"GenProp0029"
] | [
"GP:GenProp0029"
] | 1 | [
"6y1x"
] | 1 | [
"PUB00017659",
"PUB00083651"
] | [
"7592933",
"16567617"
] | [
"Incorporation of iron and sulfur from NifB cofactor into the iron-molybdenum cofactor of dinitrogenase.",
"NifB-dependent in vitro synthesis of the iron-molybdenum cofactor of nitrogenase."
] | [
1995,
2006
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Cylicocyclus nassatus",
"Methanobacteriati",
"unclassified sequences"
] | [
1703,
1,
137,
26
] | 4 | [] | [] | 0 | true | Family | Nitrogenase cofactor biosynthesis protein NifB | Nitrogenase cofactor biosynthesis protein NifB | Nase_CF_NifB | 2 |
IPR005981 | 5,981 | ABC-2 type transporter, NodJ | ABC_transptNodJ | Family | 1,076 | false | false | ABC transporters belong to the ATP-Binding Cassette (ABC) superfamily, which uses the hydrolysis of ATP to energise diverse biological systems. ABC transporters minimally consist of two conserved regions: a highly conserved ATP binding cassette (ABC) and a less conserved transmembrane domain (TMD). These can be found o... | [
"GO:0022857",
"GO:0015772",
"GO:0016020"
] | [
"transmembrane transporter activity",
"oligosaccharide transport",
"membrane"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"NCBIFAM"
] | [
"TIGR01291"
] | [
"nodJ"
] | [
1076
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00003841",
"PUB00034686",
"PUB00035597",
"PUB00062334",
"PUB00062335"
] | [
"8316086",
"8964496",
"3019841",
"8809752",
"7592394"
] | [
"The NodL and NodJ proteins from Rhizobium and Bradyrhizobium strains are similar to capsular polysaccharide secretion proteins from gram-negative bacteria.",
"The role of the nodI and nodJ genes in the transport of Nod metabolites in Rhizobium etli.",
"The nodI gene product of Rhizobium leguminosarum is closel... | [
1993,
1996,
1986,
1996,
1995
] | 5 | [
"IPR000412"
] | [] | 1 | 0 | 1 | [
"Bacteria",
"Methanocellaceae",
"unclassified sequences"
] | [
1054,
2,
20
] | 3 | [] | [] | 0 | true | Family | ABC-2 type transporter, NodJ | ABC-2 type transporter, NodJ | ABC_transptNodJ | 2 |
IPR005982 | 5,982 | Thioredoxin reductase | Thioredox_Rdtase | Family | 29,182 | false | false | Reactive oxygen species (ROS) are known mediators of intracellular signalling cascades. Excessive production of ROS may, however, lead to oxidative stress, loss of cell function, and ultimately apoptosis or necrosis. A balance between oxidant and antioxidant intracellular systems is hence vital for cell function, regul... | [
"GO:0004791",
"GO:0019430",
"GO:0005737"
] | [
"thioredoxin-disulfide reductase (NADPH) activity",
"removal of superoxide radicals",
"cytoplasm"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"NCBIFAM"
] | [
"TIGR01292"
] | [
"TRX_reduct"
] | [
29182
] | 1 | [
"EC",
"REACTOME"
] | [
"1.8.1.9",
"R-HSA-1222541"
] | [
"EC:1.8.1.9",
"REACTOME:R-HSA-1222541"
] | 2 | [
"1cl0",
"1f6m",
"1tde",
"1tdf",
"1trb",
"1vdc",
"2a87",
"2q0k",
"2q0l",
"2q7v",
"2whd",
"3d8x",
"3f8d",
"3f8p",
"3f8r",
"3ish",
"3itj",
"3r9u",
"4a5l",
"4a65",
"4cbq",
"4ccq",
"4ccr",
"4gcm",
"4jnq",
"4up3",
"4zn0",
"5m5j",
"5mh4",
"5mip",
"5miq",
"5mir"... | 55 | [
"PUB00033166"
] | [
"11728801"
] | [
"Reactive oxygen species, antioxidants, and the mammalian thioredoxin system."
] | [
2001
] | 1 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
342,
25146,
3278,
11,
405
] | 5 | [
"Arabidopsis thaliana",
"Escherichia coli (strain K12)",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)",
"Zea mays"
] | [
13,
1,
1,
3,
2,
1,
14
] | 7 | true | Family | Thioredoxin reductase | Thioredoxin reductase | Thioredox_Rdtase | 2 |
IPR005983 | 5,983 | Potassium channel, voltage-dependent, beta subunit, KCNAB | K_chnl_volt-dep_bsu_KCNAB | Family | 4,609 | false | false | Potassium channels are the most diverse group of the ion channel family [ , ]. They are important in shaping the action potential, and in neuronal excitability and plasticity [ ]. The potassium channel family is composed of several functionally distinct isoforms, which can be broadly separated into 2 groups [ ]: the pr... | [
"GO:0005249",
"GO:0006813",
"GO:0005737"
] | [
"voltage-gated potassium channel activity",
"potassium ion transport",
"cytoplasm"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"NCBIFAM"
] | [
"TIGR01293"
] | [
"Kv_beta"
] | [
4609
] | 1 | [
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC"... | [
"1.1.1.-",
"PWY-1121",
"PWY-1186",
"PWY-2541",
"PWY-2601",
"PWY-3162",
"PWY-321",
"PWY-3261",
"PWY-3722",
"PWY-5101",
"PWY-5271",
"PWY-5316",
"PWY-5392",
"PWY-5652",
"PWY-5666",
"PWY-5751",
"PWY-5782",
"PWY-5818",
"PWY-5830",
"PWY-5848",
"PWY-5867",
"PWY-5882",
"PWY-5883"... | [
"EC:1.1.1.-",
"METACYC:PWY-1121",
"METACYC:PWY-1186",
"METACYC:PWY-2541",
"METACYC:PWY-2601",
"METACYC:PWY-3162",
"METACYC:PWY-321",
"METACYC:PWY-3261",
"METACYC:PWY-3722",
"METACYC:PWY-5101",
"METACYC:PWY-5271",
"METACYC:PWY-5316",
"METACYC:PWY-5392",
"METACYC:PWY-5652",
"METACYC:PWY-56... | 157 | [
"1exb",
"1qrq",
"1zsx",
"2a79",
"2r9r",
"3eau",
"3eb3",
"3eb4",
"3lnm",
"3lut",
"4jta",
"4jtc",
"4jtd",
"5wie",
"6ci1",
"6ebk",
"6ebl",
"7ej1",
"7ej2",
"7sit",
"7siz",
"7wf3",
"7wf4"
] | 23 | [
"PUB00001055",
"PUB00001622",
"PUB00002771",
"PUB00004011",
"PUB00004020",
"PUB00006577",
"PUB00007779",
"PUB00009378"
] | [
"1772658",
"1879548",
"1373731",
"2448635",
"2451788",
"2555158",
"11294861",
"11178249"
] | [
"The molecular biology of K+ channels.",
"Shaw-like rat brain potassium channel cDNA's with divergent 3' ends.",
"Cloning, functional expression, and regulation of two K+ channels in human T lymphocytes.",
"Multiple potassium-channel components are produced by alternative splicing at the Shaker locus in Droso... | [
1991,
1991,
1992,
1988,
1988,
1989,
2001,
2000
] | 8 | [
"IPR005399"
] | [
"IPR005400",
"IPR005401",
"IPR005402"
] | 1 | 3 | 0 | [
"Bacteria",
"Eukaryota",
"ecological metagenomes"
] | [
49,
4556,
4
] | 3 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus",
"Zea mays"
] | [
43,
9,
13,
19,
17,
2
] | 6 | true | Family | Potassium channel, voltage-dependent, beta subunit, KCNAB | Potassium channel, voltage-dependent, beta subunit, KCNAB | K_chnl_volt-dep_bsu_KCNAB | 5 |
IPR005984 | 5,984 | Phospholamban | PLB | Family | 675 | false | false | Phospholamban (PLB) is a small protein (52 amino acids) that regulates the affinity of the cardiac sarcoplasmic reticulum Ca2+-ATPase (SERCA2a) for calcium. PLB is present in cardiac myocytes, in slow-twitch and smooth muscle and is expressed also in aorta endothelial cells in which it could play a role in tissue relax... | [
"GO:0042030",
"GO:1901894",
"GO:0016020"
] | [
"ATPase inhibitor activity",
"regulation of ATPase-coupled calcium transmembrane transporter activity",
"membrane"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PFAM",
"PIRSF",
"PANTHER",
"NCBIFAM",
"CDD"
] | [
"PF04272",
"PIRSF001665",
"PTHR21194",
"TIGR01294",
"cd20250"
] | [
"Phospholamban",
"PLB",
"",
"P_lamban",
"Phospholamban"
] | [
675,
564,
673,
670,
668
] | 5 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-CFA-5578775",
"R-CFA-936837",
"R-HSA-5578775",
"R-HSA-936837",
"R-MMU-5578775",
"R-MMU-936837",
"R-RNO-5578775",
"R-RNO-936837",
"R-SSC-5578775",
"R-SSC-936837"
] | [
"REACTOME:R-CFA-5578775",
"REACTOME:R-CFA-936837",
"REACTOME:R-HSA-5578775",
"REACTOME:R-HSA-936837",
"REACTOME:R-MMU-5578775",
"REACTOME:R-MMU-936837",
"REACTOME:R-RNO-5578775",
"REACTOME:R-RNO-936837",
"REACTOME:R-SSC-5578775",
"REACTOME:R-SSC-936837"
] | 10 | [
"1fjk",
"1fjp",
"1n7l",
"1plp",
"1yod",
"1zll",
"2hyn",
"2kb7",
"2kyv",
"2lpf",
"2m3b",
"3o7l",
"4kyt",
"4y3u",
"6y40"
] | 15 | [
"PUB00007919",
"PUB00094744",
"PUB00094745",
"PUB00094746"
] | [
"12080135",
"12610310",
"12705874",
"22427649"
] | [
"Structure of the 1-36 N-terminal fragment of human phospholamban phosphorylated at Ser-16 and Thr-17.",
"Dilated cardiomyopathy and heart failure caused by a mutation in phospholamban.",
"Mutation of the phospholamban promoter associated with hypertrophic cardiomyopathy.",
"Hydrophobic imbalance in the cytop... | [
2002,
2003,
2003,
2012
] | 4 | [] | [] | 0 | 0 | null | [
"Gnathostomata"
] | [
675
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
2,
1,
2
] | 4 | true | Family | Phospholamban | Phospholamban | PLB | 8 |
IPR005985 | 5,985 | Pediocin PA-1 biosynthesis protein PedC | PedC_BrcD | Family | 51 | false | false | Class II bacteriocins are small are ribosomally-synthesized, non-lantibiotic peptide antibiotics produced by many bacteria [ ]. This entry represents a protein encoded within a number of operons responsible for class II bacteriocin production [ , , ]. It is generally the third protein in the operon and, together with t... | [
"GO:0030152"
] | [
"bacteriocin biosynthetic process"
] | [
"biological_process"
] | 1 | [
"NCBIFAM"
] | [
"TIGR01295"
] | [
"PedC_BrcD"
] | [
51
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00018447",
"PUB00034682",
"PUB00034683",
"PUB00034684",
"PUB00034685",
"PUB00106599"
] | [
"8559070",
"16205711",
"1514784",
"15613003",
"12423916",
"26147827"
] | [
"Functional analysis of the pediocin operon of Pediococcus acidilactici PAC1.0: PedB is the immunity protein and PedD is the precursor processing enzyme.",
"Bacteriocins: developing innate immunity for food.",
"Cloning, expression, and nucleotide sequence of genes involved in production of pediocin PA-1, and ba... | [
1995,
2005,
1992,
2005,
2003,
2016
] | 6 | [] | [] | 0 | 0 | null | [
"Bacillota"
] | [
51
] | 1 | [] | [] | 0 | true | Family | Pediocin PA-1 biosynthesis protein PedC | Pediocin PA-1 biosynthesis protein PedC | PedC_BrcD | 3 |
IPR005986 | 5,986 | Aspartate-semialdehyde dehydrogenase, beta-type | Asp_semialdehyde_DH_beta | Family | 19,584 | false | false | Bacteria, plants and fungi metabolise aspartic acid to produce four amino acids -lysine, threonine, methionine and isoleucine -in a series of reactions known as the aspartate pathway. Additionally, several important metabolic intermediates are produced by these reactions, such as diaminopimelic acid, an essential compo... | [
"GO:0004073",
"GO:0050661",
"GO:0009088",
"GO:0009089",
"GO:0009097"
] | [
"aspartate-semialdehyde dehydrogenase activity",
"NADP binding",
"L-threonine biosynthetic process",
"L-lysine biosynthetic process via diaminopimelate",
"isoleucine biosynthetic process"
] | [
"molecular_function",
"molecular_function",
"biological_process",
"biological_process",
"biological_process"
] | 5 | [
"NCBIFAM"
] | [
"TIGR01296"
] | [
"asd_B"
] | [
19584
] | 1 | [
"EC",
"GP",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC"
] | [
"1.2.1.11",
"GenProp0160",
"PWY-2941",
"PWY-2942",
"PWY-5097",
"PWY-6160",
"PWY-6559",
"PWY-6562",
"PWY-7153",
"PWY-7977",
"PWY-8088",
"PWY-8179",
"PWY-8296"
] | [
"EC:1.2.1.11",
"GP:GenProp0160",
"METACYC:PWY-2941",
"METACYC:PWY-2942",
"METACYC:PWY-5097",
"METACYC:PWY-6160",
"METACYC:PWY-6559",
"METACYC:PWY-6562",
"METACYC:PWY-7153",
"METACYC:PWY-7977",
"METACYC:PWY-8088",
"METACYC:PWY-8179",
"METACYC:PWY-8296"
] | 13 | [
"2gyy",
"2gz1",
"2gz2",
"2gz3",
"2qz9",
"2r00",
"2yv3",
"3pwk",
"3pws",
"3pyl",
"3pyx",
"3pzb",
"3q11",
"3q1l",
"3tz6",
"3vos",
"4r3n",
"4r3w",
"4r41",
"4r4j",
"4r51",
"4r54",
"4r5h",
"8juo",
"8jus"
] | 25 | [
"PUB00029242",
"PUB00029661",
"PUB00034672",
"PUB00034673",
"PUB00034674",
"PUB00034675"
] | [
"14559965",
"15272161",
"11352712",
"1673060",
"15388927",
"16225889"
] | [
"Capture of an intermediate in the catalytic cycle of L-aspartate-beta-semialdehyde dehydrogenase.",
"The role of substrate-binding groups in the mechanism of aspartate-beta-semialdehyde dehydrogenase.",
"The central enzymes of the aspartate family of amino acid biosynthesis.",
"Chemical and kinetic mechanism... | [
2003,
2004,
2001,
1991,
2004,
2005
] | 6 | [
"IPR012080"
] | [] | 1 | 0 | 1 | [
"Bacteria",
"Eukaryota",
"Megaviridae environmental sample",
"Methanosarcinaceae",
"metagenomes"
] | [
18436,
767,
1,
18,
362
] | 5 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
4,
2,
3
] | 3 | true | Family | Aspartate-semialdehyde dehydrogenase, beta-type | Aspartate-semialdehyde dehydrogenase, beta-type | Asp_semialdehyde_DH_beta | 6 |
IPR005987 | 5,987 | Ribonuclease T | RNase_T | Family | 4,747 | false | false | Ribonuclease T ( ) is an enzyme found so far only in gamma-subdivision proteobacteria such as Escherichia coli and Xylella fastidiosa. Ribonuclease T is homologous to the DNA polymerase III alpha chain. It can liberate AMP from the common C-C-A terminus of uncharged tRNA. It appears also to be involved in RNA maturatio... | [
"GO:0004540",
"GO:0006396"
] | [
"RNA nuclease activity",
"RNA processing"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"HAMAP",
"NCBIFAM",
"CDD"
] | [
"MF_00157",
"TIGR01298",
"cd06134"
] | [
"RNase_T",
"RNaseT",
"RNaseT"
] | [
4747,
4695,
3642
] | 3 | [
"EC",
"GP"
] | [
"3.1.13.-",
"GenProp1360"
] | [
"EC:3.1.13.-",
"GP:GenProp1360"
] | 2 | [
"2f96",
"2is3",
"3ngy",
"3ngz",
"3nh0",
"3nh1",
"3nh2",
"3v9s",
"3v9u",
"3v9w",
"3v9x",
"3v9z",
"3va0",
"3va3",
"4kaz",
"4kb0",
"4kb1"
] | 17 | [
"PUB00017662"
] | [
"9857048"
] | [
"Identification of a potent DNase activity associated with RNase T of Escherichia coli."
] | [
1998
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
4694,
7,
46
] | 3 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Ribonuclease T | Ribonuclease T | RNase_T | 9 |
IPR005989 | 5,989 | Sucrose/H+ symporter, plant | Suc_symporter_pln | Family | 2,119 | false | false | These sucrose/proton symporters, found in plants, are from the Glycoside-Pentoside-Hexuronide (GPH)/cation symporter family. These proteins are predicted to have 12 transmembrane domains. Members may export sucrose (e.g. SUT1, SUT4) from green parts to the phloem for long-distance transport or import sucrose (e.g SUT2)... | [
"GO:0008515",
"GO:0015770",
"GO:0005886"
] | [
"sucrose transmembrane transporter activity",
"sucrose transport",
"plasma membrane"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"NCBIFAM"
] | [
"TIGR01301"
] | [
"GPH_sucrose"
] | [
2119
] | 1 | [] | [] | [] | 0 | [
"8bb6"
] | 1 | [
"PUB00007921"
] | [
"9847123"
] | [
"Characterization of source- and sink-specific sucrose/H+ symporters from carrot."
] | [
1998
] | 1 | [] | [] | 0 | 0 | null | [
"Embryophyta"
] | [
2119
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
33,
7,
13
] | 3 | true | Family | Sucrose/H+ symporter, plant | Sucrose/H+ symporter, plant | Suc_symporter_pln | 4 |
IPR005990 | 5,990 | Inosine-5'-monophosphate dehydrogenase | IMP_DH | Family | 43,097 | false | false | This entry includes inosine-5'-monophosphate dehydrogenases and guanosine 5'-monophosphate (GMP) reductase. Inosine-5'-monophosphate dehydrogenase catalyses the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucle... | [
"GO:0003938",
"GO:0006164"
] | [
"IMP dehydrogenase activity",
"purine nucleotide biosynthetic process"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"HAMAP",
"PIRSF",
"PANTHER",
"NCBIFAM"
] | [
"MF_01964",
"PIRSF000130",
"PTHR11911",
"TIGR01302"
] | [
"IMPDH",
"IMPDH",
"",
"IMP_dehydrog"
] | [
29069,
34003,
39266,
28820
] | 4 | [
"EC",
"GP",
"GP",
"GP",
"GP",
"GP",
"METACYC",
"METACYC",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REAC... | [
"1.1.1.205",
"GenProp0697",
"GenProp1406",
"GenProp1592",
"GenProp1650",
"GenProp1753",
"PWY-5695",
"PWY-6596",
"PWY-7221",
"R-BTA-6798695",
"R-BTA-73817",
"R-BTA-9748787",
"R-CEL-6798695",
"R-CEL-73817",
"R-CEL-9748787",
"R-DDI-6798695",
"R-DDI-73817",
"R-DDI-9748787",
"R-DME-67... | [
"EC:1.1.1.205",
"GP:GenProp0697",
"GP:GenProp1406",
"GP:GenProp1592",
"GP:GenProp1650",
"GP:GenProp1753",
"METACYC:PWY-5695",
"METACYC:PWY-6596",
"METACYC:PWY-7221",
"REACTOME:R-BTA-6798695",
"REACTOME:R-BTA-73817",
"REACTOME:R-BTA-9748787",
"REACTOME:R-CEL-6798695",
"REACTOME:R-CEL-73817"... | 40 | [
"1ak5",
"1b3o",
"1eep",
"1jcn",
"1jr1",
"1lrt",
"1me7",
"1me8",
"1me9",
"1meh",
"1mei",
"1mew",
"1nf7",
"1nfb",
"1pvn",
"1vrd",
"1zfj",
"2cu0",
"2qr6",
"3ffs",
"3khj",
"3tsb",
"3tsd",
"3usb",
"3zfh",
"4af0",
"4avf",
"4dqw",
"4fez",
"4fo4",
"4fxs",
"4ix2"... | 201 | [
"PUB00060792",
"PUB00060793",
"PUB00076685"
] | [
"8980752",
"11223253",
"7159467"
] | [
"IMP dehydrogenase from Pneumocystis carinii as a potential drug target.",
"Differential splicing of Pneumocystis carinii f. sp. carinii inosine 5'-monophosphate dehydrogenase pre-mRNA.",
"Guanosine 5'-monophosphate reductase from Leishmania donovani. A possible chemotherapeutic target."
] | [
1997,
2001,
1982
] | 3 | [] | [
"IPR005991",
"IPR005992"
] | 0 | 2 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
838,
32748,
8534,
8,
969
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
9,
3,
15,
5,
1,
24,
13,
1,
6,
10,
5,
1,
13
] | 13 | true | Family | Inosine-5'-monophosphate dehydrogenase | Inosine-5'-monophosphate dehydrogenase | IMP_DH | 3 |
IPR005991 | 5,991 | GMP reductase GuaB1 | GUAB1 | Family | 3,784 | false | false | This family of proteins restricted to the high GC Gram-positive bacteria includes GMP reductase from Mycobacterium smegmatis (GUAB1), which is involved in the purine-salvage pathway. This protein is composed of two domains: a catalytic domain with a TIM barrel structure and another that folds as a typical Bateman domai... | [] | [] | [] | 0 | [
"HAMAP",
"NCBIFAM"
] | [
"MF_02250",
"TIGR01303"
] | [
"GMPR_GuaB1",
"IMP_DH_rel_1"
] | [
3714,
3762
] | 2 | [
"EC"
] | [
"1.7.1.7"
] | [
"EC:1.7.1.7"
] | 1 | [
"7oy9",
"7r50",
"8ry0",
"8ry1",
"8ry3",
"8ry4",
"8ry5",
"8ry6",
"8ry7",
"8ry8",
"8ry9",
"8rya",
"8ryb",
"9hfz",
"9hg0",
"9hg1",
"9hg2",
"9hg3"
] | 18 | [
"PUB00060775",
"PUB00101093"
] | [
"21081761",
"35338694"
] | [
"Identification of novel diphenyl urea inhibitors of Mt-GuaB2 active against Mycobacterium tuberculosis.",
"The mycobacterial guaB1 gene encodes a guanosine 5'-monophosphate reductase with a cystathionine-β-synthase domain."
] | [
2011,
2022
] | 2 | [
"IPR005990"
] | [] | 1 | 0 | 1 | [
"Bacteria",
"metagenomes"
] | [
3674,
110
] | 2 | [] | [] | 0 | true | Family | GMP reductase GuaB1 | GMP reductase GuaB1 | GUAB1 | 8 |
IPR005992 | 5,992 | IMP dehydrogenase-related 2 | IMP_DH-rel2 | Family | 5,087 | false | false | This family of proteins, often annotated as a putative IMP dehydrogenase, are related to IMP dehydrogenase and GMP reductase. Most species with a member of this family belong to the high GC Gram-positive bacteria. | [
"GO:0016491"
] | [
"oxidoreductase activity"
] | [
"molecular_function"
] | 1 | [
"NCBIFAM"
] | [
"TIGR01304"
] | [
"IMP_DH_rel_2"
] | [
5087
] | 1 | [] | [] | [] | 0 | [
"2qr6",
"8p37",
"8p4q"
] | 3 | [] | [] | [] | [] | 0 | [
"IPR005990"
] | [] | 1 | 0 | 1 | [
"Bacteria",
"Eukaryota",
"metagenomes",
"uncultured marine thaumarchaeote KM3_78_A04"
] | [
4913,
7,
166,
1
] | 4 | [] | [] | 0 | true | Family | IMP dehydrogenase-related 2 | IMP dehydrogenase-related 2 | IMP_DH-rel2 | 7 |
IPR005993 | 5,993 | GMP reductase | GMPR | Family | 4,753 | false | false | GMP (guanosine monophosphate) reductase catalyses the irreversible and NADPH-dependent reductive deamination of GMP into IMP. NADPH + guanosine 5-phosphate = NADP+ + inosine 5-phosphate + NH3 It converts nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and maintains intracellular balance of A an... | [
"GO:0003920",
"GO:0009117",
"GO:1902560"
] | [
"GMP reductase activity",
"nucleotide metabolic process",
"GMP reductase complex"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"HAMAP",
"PIRSF",
"NCBIFAM"
] | [
"MF_00596",
"PIRSF000235",
"TIGR01305"
] | [
"GMP_reduct_type1",
"GMP_reductase",
"GMP_reduct_1"
] | [
4728,
4427,
4390
] | 3 | [
"EC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"1.7.1.7",
"R-CEL-74217",
"R-HSA-74217",
"R-HSA-9854909",
"R-MMU-74217",
"R-RNO-74217"
] | [
"EC:1.7.1.7",
"REACTOME:R-CEL-74217",
"REACTOME:R-HSA-74217",
"REACTOME:R-HSA-9854909",
"REACTOME:R-MMU-74217",
"REACTOME:R-RNO-74217"
] | 6 | [
"2a7r",
"2ble",
"2bwg",
"2bzn",
"2c6q"
] | 5 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"metagenomes"
] | [
18,
2238,
2425,
8,
64
] | 5 | [
"Caenorhabditis elegans",
"Danio rerio",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
2,
1,
9,
3,
9
] | 6 | true | Family | GMP reductase | GMP reductase | GMPR | 6 |
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