LiteFold/InterPro · Datasets at Hugging Face

IPR005644

5,644

NolW-like

Domain

22,243

false

This is a group of NolW-like proteins, which are closely related to bacterial type II and III secretion system protein ( ). NolW proteins have putative membrane-spanning regions [ ].

[]

0

[ "PFAM" ]

[ "PF03958" ]

[ "Secretin_N" ]

[ 22243 ]

1

[ "GP", "REACTOME" ]

[ "GenProp0052", "R-HSA-9760173" ]

[ "GP:GenProp0052", "REACTOME:R-HSA-9760173" ]

2

[ "2y3m", "2y9k", "3ezj", "3j1v", "3jc8", "3jc9", "3oss", "4av2", "4e9j", "4ec5", "4g08", "5mp2", "5ngi", "5tcq", "5tcr", "5w68", "5wln", "5wq7", "5wq8", "5wq9", "5zdh", "6dv3", "6dv6", "6hcg", "6i1x", "6i1y", "6pee", "6pem", "6pep", "6q14", "6q15", "6q16"...

45

[ "PUB00012767" ]

[ "8412662" ]

[ "Molecular cloning and characterization of a sym plasmid locus that regulates cultivar-specific nodulation of soybean by Rhizobium fredii USDA257." ]

[ 1993 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "Inoviridae", "environmental samples", "unclassified sequences" ]

[ 21820, 41, 17, 2, 363 ]

5

[ "Escherichia coli (strain K12)" ]

[ 2 ]

1

true

Domain

NolW-like

5

IPR005645

5,645

Serine hydrolase domain

FSH-like_dom

Domain

14,539

false

This domain is found in a number of enzymes possessing esterase and hydrolase activity. This domain can be found in budding yeast Fsh1/2/3, fission yeast Dfr1 and the human OVCA2 protein. Fsh1/2/3 are putative serine hydrolases [ ]. Dfr1 is a dihydrofolate reductase (DHFR) [ ]. OVCA2 is a putative serine-hydrolase that...

[]

0

[ "PFAM" ]

[ "PF03959" ]

[ "FSH1" ]

[ 14539 ]

1

[ "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC"...

[ "3.1.2.-", "PWY-3602", "PWY-5109", "PWY-6322", "PWY-6585", "PWY-6917", "PWY-6948", "PWY-6995", "PWY-6997", "PWY-7007", "PWY-7216", "PWY-7292", "PWY-7401", "PWY-7402", "PWY-7471", "PWY-7690", "PWY-7706", "PWY-7733", "PWY-7734", "PWY-7738", "PWY-7740", "PWY-7741", "PWY-7742...

[ "EC:3.1.2.-", "METACYC:PWY-3602", "METACYC:PWY-5109", "METACYC:PWY-6322", "METACYC:PWY-6585", "METACYC:PWY-6917", "METACYC:PWY-6948", "METACYC:PWY-6995", "METACYC:PWY-6997", "METACYC:PWY-7007", "METACYC:PWY-7216", "METACYC:PWY-7292", "METACYC:PWY-7401", "METACYC:PWY-7402", "METACYC:PWY-7...

35

[ "1ycd" ]

1

[ "PUB00055605", "PUB00079205", "PUB00079206", "PUB00079208" ]

[ "14645503", "16368187", "8088538", "23653178" ]

[ "Synergistic computational and experimental proteomics approaches for more accurate detection of active serine hydrolases in yeast.", "Mass spectrometric identification of serine hydrolase OVCA2 in the medulloblastoma cell line DAOY.", "The isolation and characterization of the gene (dfr1) encoding dihydrofolat...

[ 2004, 2006, 1994, 2013 ]

4

[]

0

null

[ "Bacteria", "Eukaryota", "Methanobacteriota", "Viruses", "unclassified sequences" ]

[ 611, 13878, 5, 30, 15 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 22, 1, 1, 2, 1, 1, 5, 11, 3, 3, 2, 28 ]

12

true

Domain

Serine hydrolase domain

FSH-like_dom

6

IPR005646

5,646

Flagellar assembly protein A

FapA

Family

4,612

false

Members of this family include FapA (flagellar assembly protein A), , found in Vibrio vulnificus. The synthesis of flagella allows bacteria to respond to chemotaxis by facilitating motility. Studies examining the role of FapA show that the loss or delocalization of FapA results in a complete failure of the flagellar bi...

[]

0

[ "PANTHER" ]

[ "PTHR38032" ]

[ "" ]

[ 4612 ]

1

[]

0

[]

0

[ "PUB00085059" ]

[ "27218601" ]

[ "Glucose induces delocalization of a flagellar biosynthesis protein from the flagellated pole." ]

[ 2016 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 4551, 3, 58 ]

3

[]

0

true

Family

Flagellar assembly protein A

FapA

3

IPR005647

5,647

Meiotic nuclear division protein 1

Mnd1

Family

2,899

false

This entry includes budding yeast Mnd1 and fission yeast Mcp7. Mnd1 forms a complex with hop2 to promote homologous chromosome pairing and meiotic double-strand break repair [ ]. Mcp7 interacts with Meu13 and is required for meiotic recombination [ ].

[ "GO:0003690", "GO:0007131" ]

[ "double-stranded DNA binding", "reciprocal meiotic recombination" ]

[ "molecular_function", "biological_process" ]

2

[ "PIRSF" ]

[ "PIRSF026991" ]

[ "Mnd1" ]

[ 2899 ]

1

[ "REACTOME" ]

[ "R-HSA-912446" ]

[ "REACTOME:R-HSA-912446" ]

1

[ "4y66" ]

1

[ "PUB00008481", "PUB00092543" ]

[ "11940665", "15210864" ]

[ "The Mnd1 protein forms a complex with hop2 to promote homologous chromosome pairing and meiotic double-strand break repair.", "Mcp7, a meiosis-specific coiled-coil protein of fission yeast, associates with Meu13 and is required for meiotic recombination." ]

[ 2002, 2004 ]

2

[]

0

null

[ "Eukaryota" ]

[ 2899 ]

1

[ "Arabidopsis thaliana", "Danio rerio", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)", "Zea mays" ]

[ 5, 2, 2, 1, 2, 3, 1, 1, 7 ]

9

true

Family

Meiotic nuclear division protein 1

Mnd1

7

IPR005648

5,648

Flagellar hook capping protein

FlgD

Family

13,538

false

FlgD is known to be absolutely required for hook assembly, yet it has not been detected in the mature flagellum [ ]. It appears to act as a hook-capping protein to enable assembly of hook protein subunits [ ].

[]

0

[ "PFAM" ]

[ "PF03963" ]

[ "FlgD" ]

[ 13538 ]

1

[ "GP" ]

[ "GenProp0881" ]

[ "GP:GenProp0881" ]

1

[ "7bhq", "7eha", "7nvg" ]

3

[ "PUB00008482" ]

[ "8157595" ]

[ "FlgD is a scaffolding protein needed for flagellar hook assembly in Salmonella typhimurium." ]

[ 1994 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 13368, 21, 149 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Flagellar hook capping protein

FlgD

7

IPR005649

5,649

Chorion 2

Chorion_2

Family

91

false

The chorion genes of Drosophila are amplified in response to developmental signals in the follicle cells of the ovary [ , ].

[ "GO:0007275", "GO:0042600" ]

[ "multicellular organism development", "egg chorion" ]

[ "biological_process", "cellular_component" ]

2

[ "PFAM" ]

[ "PF03964" ]

[ "Chorion_2" ]

[ 91 ]

1

[]

0

[]

0

[ "PUB00008483", "PUB00012823" ]

[ "1908228", "11404001" ]

[ "Drosophila chorion genes: cracking the eggshell's secrets.", "The chorion genes of the medfly. II. DNA sequence evolution of the autosomal chorion genes s18, s15, s19 and s16 in Diptera." ]

[ 1991, 2001 ]

2

[]

0

null

[ "Diptera" ]

[ 91 ]

1

[ "Drosophila melanogaster" ]

[ 4 ]

1

true

Family

Chorion 2

Chorion_2

7

IPR005650

5,650

BlaI transcriptional regulatory family

BlaI_family

Family

24,945

false

Proteins in this entry are transcriptional regulators found in a variety of bacteria and a small number of archaea. Many are BlaI/MecI proteins which regulate resistance to penicillins (beta-lactams), though at least one protein ( ) appears to be involved in the regulation of copper homeostasis [ ]. BlaI regulators rep...

[ "GO:0003677", "GO:0045892" ]

[ "DNA binding", "negative regulation of DNA-templated transcription" ]

[ "molecular_function", "biological_process" ]

2

[ "PFAM", "PIRSF" ]

[ "PF03965", "PIRSF019455" ]

[ "Penicillinase_R", "CopR_AtkY" ]

[ 24945, 16542 ]

2

[]

0

[ "1okr", "1p6r", "1sax", "1sd4", "1sd6", "1sd7", "1xsd", "2d45", "2g9w", "2k4b", "2p7c" ]

11

[ "PUB00028063", "PUB00028064", "PUB00028065" ]

[ "7876197", "14568532", "12881514" ]

[ "Two trans-acting metalloregulatory proteins controlling expression of the copper-ATPases of Enterococcus hirae.", "Solution structural study of BlaI: implications for the repression of genes involved in beta-lactam antibiotic resistance.", "Three-dimensional structure of MecI. Molecular basis for transcription...

[ 1995, 2003, 2003 ]

3

[]

[ "IPR014071" ]

0

1

0

[ "Archaea", "Bacteria", "Caudoviricetes", "Eukaryota", "metagenomes" ]

[ 191, 24493, 24, 17, 220 ]

5

[]

0

true

Family

BlaI transcriptional regulatory family

BlaI_family

4

IPR005652

5,652

Photosynthetic reaction centre, H subunit

Photo_RC_H

Family

643

false

This entry describes the photosynthetic reaction centre H subunit, which has a single transmembrane helix and a large cytoplasmic domain [ ]. The core of the cytoplasmic domain has a PRC-barrel structure. The photosynthetic apparatus in non-oxygenic bacteria consists of light-harvesting (LH) protein-pigment complexes L...

[ "GO:0019684", "GO:0030077" ]

[ "photosynthesis, light reaction", "plasma membrane light-harvesting complex" ]

[ "biological_process", "cellular_component" ]

2

[ "NCBIFAM" ]

[ "TIGR01150" ]

[ "puhA" ]

[ 643 ]

1

[ "GP" ]

[ "GenProp0662" ]

[ "GP:GenProp0662" ]

1

[ "1aig", "1aij", "1ds8", "1dv3", "1dv6", "1dxr", "1e14", "1e6d", "1eys", "1f6n", "1fnp", "1fnq", "1jgw", "1jgx", "1jgy", "1jgz", "1jh0", "1k6l", "1k6n", "1kby", "1l9b", "1l9j", "1m3x", "1mps", "1ogv", "1pcr", "1prc", "1pss", "1pst", "1qov", "1r2c", "1rg5"...

219

[ "PUB00014111", "PUB00014116", "PUB00014117", "PUB00015279", "PUB00015395", "PUB00034760", "PUB00034761", "PUB00034762" ]

[ "11095707", "11005826", "10611277", "2676514", "12872158", "15329728", "16931113", "8027023" ]

[ "Crystal structures of photosynthetic reaction center and high-potential iron-sulfur protein from Thermochromatium tepidum: thermostability and electron transfer.", "Structural basis of the drastically increased initial electron transfer rate in the reaction center from a Rhodopseudomonas viridis mutant described...

[ 2000, 2000, 1999, 1989, 2003, 2004, 2006, 1994 ]

8

[]

0

null

[ "Bacteria", "Symbiodinium necroappetens", "freshwater sediment metagenome" ]

[ 641, 1, 1 ]

3

[]

0

true

Family

Photosynthetic reaction centre, H subunit

Photo_RC_H

9

IPR005653

5,653

Organic solvent tolerance-like, N-terminal

OstA-like_N

Domain

19,848

false

This domain is found in a number of bacterial proteins, including the LPS-assembly protein lptD, which is involved in organic solvent tolerance [ ]. It is also found in lipopolysaccharide export system protein LptH that is responsible for lipopolysaccharide and lipoproteins transport to the outer membrane respectively,...

[]

0

[ "PFAM", "PFAM" ]

[ "PF03968", "PF13100" ]

[ "LptD_N", "OstA_2" ]

[ 17290, 2780 ]

2

[]

0

[ "2r19", "2r1a", "4n4r", "4q35", "4uu4", "5iv9", "6gd5", "7qs6", "7zax", "7zed", "8bss", "8gaj", "8gak", "8gal", "8h1r", "8h1s", "8onu", "9fz5", "9i92", "9i93", "9i94", "9i95", "9i96", "9i97", "9i98", "9kn3", "9q8n" ]

27

[ "PUB00008485", "PUB00151176" ]

[ "7811102", "26621210" ]

[ "Cloning of organic solvent tolerance gene ostA that determines n-hexane tolerance level in Escherichia coli.", "In vitro and in vivo screening for novel essential cell-envelope proteins in Pseudomonas aeruginosa." ]

[ 1994, 2015 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 19503, 29, 316 ]

3

[ "Escherichia coli (strain K12)" ]

[ 2 ]

1

true

Domain

Organic solvent tolerance-like, N-terminal

OstA-like_N

4

IPR005654

5,654

ATPase, AFG1-like

ATPase_AFG1-like

Family

22,891

false

This P-loop motif-containing family of proteins includes AFG1, LACE1 and ZapE. ATPase family gene 1 (AFG1) is a 377 amino acid yeast protein with an ATPase motif typical of the family [ ]. AFG1-like ATPase (also known as lactation elevated 1 or LACE1), the mammalian homologue of AGF1, is a mitochondrial integral membra...

[ "GO:0005524", "GO:0016887" ]

[ "ATP binding", "ATP hydrolysis activity" ]

[ "molecular_function", "molecular_function" ]

2

[ "NCBIFAM", "PFAM", "PANTHER" ]

[ "NF040713", "PF03969", "PTHR12169" ]

[ "ZapE", "AFG1_ATPase", "" ]

[ 21303, 22804, 22601 ]

3

[]

0

[]

0

[ "PUB00019112", "PUB00074167", "PUB00081939", "PUB00105925", "PUB00105926" ]

[ "1441755", "24595368", "26759378", "32579605", "34646253" ]

[ "AFG1, a new member of the SEC18-NSF, PAS1, CDC48-VCP, TBP family of ATPases.", "ZapE is a novel cell division protein interacting with FtsZ and modulating the Z-ring dynamics.", "The mammalian homologue of yeast Afg1 ATPase (lactation elevated 1) mediates degradation of nuclear-encoded complex IV subunits.", ...

[ 1992, 2014, 2016, 2020, 2021 ]

5

[]

[ "IPR030870" ]

0

1

0

[ "Bacteria", "Eukaryota", "Myoviridae sp. ctByu2", "unclassified sequences" ]

[ 14962, 7785, 1, 143 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus",...

[ 18, 1, 10, 1, 1, 4, 5, 2, 8, 5, 1, 1, 34 ]

13

true

Family

ATPase, AFG1-like

ATPase_AFG1-like

5

IPR005655

5,655

Herpesvirus UL37

Herpes_UL37

Family

307

false

The herpes simplex virus 1 (HSV-1) UL37 protein functions in both retrograde and anterograde transport of virion capsids, and plays critical roles in cytoplasmic virion envelopment by interacting with glycoprotein K and UL20 [ , ]. It also interacts with UL36, which is thought to be an important early step in tegumenta...

[ "GO:0019068" ]

[ "virion assembly" ]

[ "biological_process" ]

1

[ "PFAM" ]

[ "PF03970" ]

[ "Herpes_UL37_1" ]

[ 307 ]

1

[]

0

[ "4k70", "5j2z", "5vyl" ]

3

[ "PUB00008486", "PUB00083122", "PUB00083125" ]

[ "11861875", "27630233", "24600000" ]

[ "Pseudorabies virus UL36 tegument protein physically interacts with the UL37 protein.", "Herpes Simplex Virus 1 UL37 Protein Tyrosine Residues Conserved among All Alphaherpesviruses Are Required for Interactions with Glycoprotein K, Cytoplasmic Virion Envelopment, and Infectious Virus Production.", "Herpes simp...

[ 2002, 2016, 2014 ]

3

[ "IPR034738" ]

[]

1

0

1

[ "Herpesvirales" ]

[ 307 ]

1

[]

0

true

Family

Herpesvirus UL37

Herpes_UL37

5

IPR005656

5,656

MmgE/PrpD

MmgE_PrpD

Family

23,073

false

This entry represents proteins from the MmgE/PrpD family, which includes 2-methylcitrate dehydratase (PrpD; ). PrpD is required for propionate catabolism, catalysing the third step of the 2-methylcitric acid cycle [ ]. This enzyme consists of two domains: a large domain with an all-helical fold and a smaller domain tha...

[ "GO:0016829" ]

[ "lyase activity" ]

[ "molecular_function" ]

1

[ "PANTHER" ]

[ "PTHR16943" ]

[ "" ]

[ 23073 ]

1

[ "EC", "GP" ]

[ "4.2.1", "GenProp1687" ]

[ "EC:4.2.1", "GP:GenProp1687" ]

2

[ "1szq", "2hp0", "2hp3", "5mux", "5mvi", "6r6t", "6r6u", "6s62", "7br9", "7bra", "7e9d" ]

11

[ "PUB00017752", "PUB00036075", "PUB00075343", "PUB00090961" ]

[ "11782506", "16934291", "18584171", "28956599" ]

[ "AcnC of Escherichia coli is a 2-methylcitrate dehydratase (PrpD) that can use citrate and isocitrate as substrates.", "Three-dimensional structure of iminodisuccinate epimerase defines the fold of the MmgE/PrpD protein family.", "Cloning and functional characterization of the cis-aconitic acid decarboxylase (C...

[ 2002, 2006, 2008, 2017 ]

4

[]

[ "IPR012705" ]

0

1

0

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 431, 17149, 5114, 379 ]

4

[ "Danio rerio", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)" ]

[ 2, 1, 1, 2, 1, 2, 1 ]

7

true

Family

MmgE/PrpD

MmgE_PrpD

4

IPR005657

5,657

Triabin/Procalin

Triabi/Procalin

Family

773

false

This family contains saliva proteins from haematophagous insects that counteract vertebrate host haemostasis events such as coagulation, vasoconstriction and platelet aggregation [ ]. These include: Triabin, a serine-protease inhibitor with a calycin fold [ ]. It forms a non-covalent complex with thrombin at a molecula...

[ "GO:0030682" ]

[ "symbiont-mediated perturbation of host defenses" ]

[ "biological_process" ]

1

[ "PFAM" ]

[ "PF03973" ]

[ "Triabin" ]

[ 773 ]

1

[]

0

[ "1avg", "3ebk", "4n7c", "4n7d", "5h9k", "5h9l", "5h9n", "5ha0", "5hae" ]

9

[ "PUB00015042", "PUB00020487", "PUB00028066", "PUB00101077", "PUB00101078", "PUB00101079", "PUB00158924", "PUB00158925" ]

[ "12421416", "9342325", "11509613", "2611041", "22159626", "20889972", "17645545", "22771751" ]

[ "Molecular cloning and sequencing of salivary gland-specific cDNAs of the blood-sucking bug Triatoma brasiliensis (Hemiptera: Reduviidae).", "Structure of the thrombin complex with triabin, a lipocalin-like exosite-binding inhibitor derived from a triatomine bug.", "Identification, cloning, and recombinant expr...

[ 2002, 1997, 2001, 1989, 2012, 2010, 2007, 2012 ]

8

[]

0

null

[ "Eukaryota" ]

[ 773 ]

1

[]

0

true

Family

Triabin/Procalin

Triabi/Procalin

9

IPR005658

5,658

Proteinase inhibitor I11, ecotin

Prot_inh_ecotin

Family

2,463

false

This entry represents proteinase inhibitors that belong to MEROPS inhibitor family I11, clan IN. Ecotins are dimeric periplasmic proteins from Escherichia coli and related Gram-negative bacteria that have been shown to be potent inhibitors of many trypsin-fold serine proteases of widely varying substrate specificity, w...

[ "GO:0004867" ]

[ "serine-type endopeptidase inhibitor activity" ]

[ "molecular_function" ]

1

[ "PFAM", "PIRSF", "PANTHER" ]

[ "PF03974", "PIRSF006865", "PTHR35890" ]

[ "Ecotin", "Prot_inh_ecotin", "" ]

[ 2463, 1963, 2394 ]

3

[]

0

[ "1azz", "1ecy", "1ecz", "1ezs", "1ezu", "1fi8", "1id5", "1ifg", "1n8o", "1p0s", "1slu", "1slv", "1slw", "1slx", "1xx9", "1xxd", "1xxf", "2y6t", "4iw4", "4niy", "7cbk", "7pqn", "7pqo" ]

23

[ "PUB00014133", "PUB00014201" ]

[ "14705960", "14705961" ]

[ "Evolutionary families of peptidase inhibitors.", "The periplasmic serine protease inhibitor ecotin protects bacteria against neutrophil elastase." ]

[ 2004, 2004 ]

2

[]

[ "IPR023084" ]

0

1

0

[ "Bacteria", "Eukaryota", "ecological metagenomes" ]

[ 2352, 107, 4 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Proteinase inhibitor I11, ecotin

Prot_inh_ecotin

7

IPR005659

5,659

Chemoreceptor glutamine deamidase CheD

Chemorcpt_Glu_NH3ase_CheD

Family

8,435

false

CheD deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs). CheD-mediated MCP deamidation is required for productive communication of the conformational signals of the chemoreceptors to the cheA kinase [ ]. CheC is a CheY-P phosphatase (CheY controls flagellar rotation and is activa...

[ "GO:0050568", "GO:0006935" ]

[ "protein-glutamine glutaminase activity", "chemotaxis" ]

[ "molecular_function", "biological_process" ]

2

[ "HAMAP", "PFAM", "PANTHER", "CDD" ]

[ "MF_01440", "PF03975", "PTHR35147", "cd16352" ]

[ "CheD", "CheD", "", "CheD" ]

[ 8060, 8418, 8329, 8390 ]

4

[ "EC" ]

[ "3.5.1.44" ]

[ "EC:3.5.1.44" ]

1

[ "2f9z" ]

1

[ "PUB00019299", "PUB00043343" ]

[ "8866475", "17908686" ]

[ "CheC and CheD interact to regulate methylation of Bacillus subtilis methyl-accepting chemotaxis proteins.", "The CheC phosphatase regulates chemotactic adaptation through CheD." ]

[ 1996, 2007 ]

2

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "metagenomes" ]

[ 501, 7786, 12, 136 ]

4

[]

0

true

Family

Chemoreceptor glutamine deamidase CheD

Chemorcpt_Glu_NH3ase_CheD

5

IPR005661

5,661

Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit

OadB_MmdB

Family

11,312

false

Members of this family are integral membrane proteins and includes oxaloacetate decarboxylase beta chain and methylmalonyl-CoA decarboxylase subunit beta. The decarboxylation reactions they catalyse are coupled to the vectorial transport of Na across the cytoplasmic membrane, thereby creating a sodium ion motive force ...

[ "GO:0016829", "GO:0006814" ]

[ "lyase activity", "sodium ion transport" ]

[ "molecular_function", "biological_process" ]

2

[ "PFAM", "PIRSF", "PANTHER", "NCBIFAM" ]

[ "PF03977", "PIRSF015658", "PTHR35806", "TIGR01109" ]

[ "OAD_beta", "MmdB_OadB", "", "Na_pump_decarbB" ]

[ 11311, 7162, 11214, 9370 ]

4

[ "EC" ]

[ "7.2.4.2" ]

[ "EC:7.2.4.2" ]

1

[ "6iva", "6iww" ]

2

[ "PUB00016214", "PUB00099625" ]

[ "9428714", "32459174" ]

[ "Methylmalonyl-CoA decarboxylase from Propionigenium modestum--cloning and sequencing of the structural genes and purification of the enzyme complex.", "Structural insights into sodium transport by the oxaloacetate decarboxylase sodium pump." ]

[ 1997, 2020 ]

2

[]

[ "IPR017558" ]

0

1

0

[ "Archaea", "Bacteria", "Eukaryota", "unclassified Caudoviricetes", "unclassified sequences" ]

[ 72, 10980, 11, 2, 247 ]

5

[]

0

true

Family

Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit

OadB_MmdB

3

IPR005662

5,662

GTPase Era-like

GTPase_Era-like

Family

33,519

false

Era is an essential G-protein in Escherichia coli identified originally as a homologue protein to Ras (E. coli Ras-like protein), which contains a N-terminal GTPase domain followed by an RNA-binding KH domain, that plays a role in ribosome biogenesis. It binds to GTP/GDP and has GTPase activity. It specifically bind to...

[ "GO:0003723", "GO:0005525" ]

[ "RNA binding", "GTP binding" ]

[ "molecular_function", "molecular_function" ]

2

[ "HAMAP", "PANTHER", "NCBIFAM" ]

[ "MF_00367", "PTHR42698", "TIGR00436" ]

[ "GTPase_Era", "", "era" ]

[ 25818, 33489, 25137 ]

3

[ "GP", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "GenProp0802", "R-BTA-5389840", "R-BTA-5419276", "R-BTA-9937383", "R-CEL-5389840", "R-CEL-5419276", "R-CEL-9937383", "R-DRE-5389840", "R-DRE-5419276", "R-HSA-5368286", "R-HSA-5389840", "R-HSA-5419276", "R-HSA-9937383", "R-MMU-5389840", "R-MMU-5419276", "R-MMU-9937383", "R-RNO-5389840...

[ "GP:GenProp0802", "REACTOME:R-BTA-5389840", "REACTOME:R-BTA-5419276", "REACTOME:R-BTA-9937383", "REACTOME:R-CEL-5389840", "REACTOME:R-CEL-5419276", "REACTOME:R-CEL-9937383", "REACTOME:R-DRE-5389840", "REACTOME:R-DRE-5419276", "REACTOME:R-HSA-5368286", "REACTOME:R-HSA-5389840", "REACTOME:R-HSA-...

19

[ "1ega", "1wf3", "1x18", "1x1l", "3ieu", "3iev", "3r9w", "3r9x", "7c1o", "8csp", "8csq", "9jkp" ]

12

[ "PUB00007879", "PUB00055805", "PUB00150958", "PUB00150959", "PUB00150960", "PUB00154442", "PUB00154443" ]

[ "10527840", "19706445", "28449065", "20604745", "36482135", "31769790", "38408251" ]

[ "Era, an essential Escherichia coli small G-protein, binds to the 30S ribosomal subunit.", "Structure of ERA in complex with the 3' end of 16S rRNA: implications for ribosome biogenesis.", "A homozygous missense mutation in ERAL1, encoding a mitochondrial rRNA chaperone, causes Perrault syndrome.", "Human ERA...

[ 1999, 2009, 2017, 2010, 2023, 2019, 2024 ]

7

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 12, 28906, 4051, 2, 548 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 9, 1, 1, 1, 1, 5, 5, 6, 9, 20 ]

10

true

Family

GTPase Era-like

GTPase_Era-like

4

IPR005663

5,663

Monovalent cation proton antiporter subunit A

MrpA/MnhA1/PhaAB

Family

1,824

false

This family of proteins consists of bacterial multicomponent K+:H+ and Na+:H+ antiporters. The best characterised systems are the MrpABCDEFG system of Bacillus subtilis which functions as a Na+:H+ antiporter [ ], PhaABCDEFG system of Rhizobium meliloti which functions in pH adaptation and as a K+ efflux system and the ...

[ "GO:0015297", "GO:0055085", "GO:1902600" ]

[ "antiporter activity", "transmembrane transport", "proton transmembrane transport" ]

[ "molecular_function", "biological_process", "biological_process" ]

3

[ "NCBIFAM" ]

[ "TIGR00940" ]

[ "2a6301s01" ]

[ 1824 ]

1

[]

0

[ "6z16", "7qru" ]

2

[ "PUB00067873" ]

[ "17693497" ]

[ "Complex formation by the mrpABCDEFG gene products, which constitute a principal Na+/H+ antiporter in Bacillus subtilis." ]

[ 2007 ]

1

[]

0

null

[ "Bacteria", "bioreactor metagenome" ]

[ 1823, 1 ]

2

[]

0

true

Family

Monovalent cation proton antiporter subunit A

MrpA/MnhA1/PhaAB

7

IPR005664

5,664

Tetrahydrodipicolinate N-succinyltransferase, transferase hexapeptide repeat family

DapD_Trfase_Hexpep_rpt_fam

Family

7,504

false

Bacteria, plants and fungi metabolise aspartic acid to produce four amino acids -lysine, threonine, methionine and isoleucine -in a series of reactions known as the aspartate pathway. Additionally, several important metabolic intermediates are produced by these reactions, such as diaminopimelic acid, an essential compo...

[ "GO:0008666", "GO:0009089" ]

[ "2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase activity", "L-lysine biosynthetic process via diaminopimelate" ]

[ "molecular_function", "biological_process" ]

2

[ "HAMAP", "NCBIFAM" ]

[ "MF_00811", "TIGR00965" ]

[ "DapD", "dapD" ]

[ 7410, 7501 ]

2

[ "EC", "GP" ]

[ "2.3.1.117", "GenProp0786" ]

[ "EC:2.3.1.117", "GP:GenProp0786" ]

2

[ "1kgq", "1kgt", "1tdt", "2tdt", "3bxy", "3eg4", "3gos", "3tdt", "3tk8", "6amy", "6amz", "6ckt", "6wqm", "9o8n", "9o8y" ]

15

[ "PUB00013971", "PUB00020828", "PUB00034672", "PUB00055043" ]

[ "11910040", "9012664", "11352712", "20418392" ]

[ "Acyl group specificity at the active site of tetrahydridipicolinate N-succinyltransferase.", "Three-dimensional structure of tetrahydrodipicolinate N-succinyltransferase.", "The central enzymes of the aspartate family of amino acid biosynthesis.", "Methanococci use the diaminopimelate aminotransferase (DapL)...

[ 2002, 1997, 2001, 2010 ]

4

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 7397, 21, 86 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Tetrahydrodipicolinate N-succinyltransferase, transferase hexapeptide repeat family

DapD_Trfase_Hexpep_rpt_fam

7

IPR005666

5,666

Sulphate transport system permease protein 1

Sulph_transpt1

Domain

8,808

false

ABC transporters belong to the ATP-Binding Cassette (ABC) superfamily, which uses the hydrolysis of ATP to energise diverse biological systems. ABC transporters minimally consist of two conserved regions: a highly conserved ATP binding cassette (ABC) and a less conserved transmembrane domain (TMD). These can be found o...

[ "GO:0015419", "GO:1902358", "GO:0016020", "GO:0043190" ]

[ "ABC-type sulfate transporter activity", "sulfate transmembrane transport", "membrane", "ATP-binding cassette (ABC) transporter complex" ]

[ "molecular_function", "biological_process", "cellular_component", "cellular_component" ]

4

[ "NCBIFAM", "CDD" ]

[ "TIGR00968", "cd03296" ]

[ "3a0106s01", "ABC_CysA_sulfate_importer" ]

[ 8804, 6417 ]

2

[ "EC", "GP", "REACTOME" ]

[ "7.3.2.3", "GenProp0191", "R-MTU-936635" ]

[ "EC:7.3.2.3", "GP:GenProp0191", "REACTOME:R-MTU-936635" ]

3

[ "1z47" ]

1

[ "PUB00004290", "PUB00014769", "PUB00017894", "PUB00017895", "PUB00017896", "PUB00017897", "PUB00017898", "PUB00017899", "PUB00025109", "PUB00026406", "PUB00035343", "PUB00043654" ]

[ "9872322", "9873074", "11421269", "1282354", "9640644", "11988180", "11470432", "11402022", "11080142", "11532960", "2188958", "11421270" ]

[ "Crystal structure of the ATP-binding subunit of an ABC transporter.", "Getting in or out: early segregation between importers and exporters in the evolution of ATP-binding cassette (ABC) transporters.", "ABC transporters: physiology, structure and mechanism--an overview.", "ABC transporters: from microorgani...

[ 1998, 1999, 2001, 1992, 1998, 2002, 2001, 2001, 2000, 2001, 1990, 2001 ]

12

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 8699, 86, 23 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Domain

Sulphate transport system permease protein 1

Sulph_transpt1

7

IPR005667

5,667

Sulphate ABC transporter permease protein 2

Sulph_transpt2

Family

21,070

false

Bacterial binding protein-dependent transport systems [ , ] are multicomponent systems typically composed of a periplasmic substrate-binding protein, one or two reciprocally homologous integral inner-membrane proteins and one or two peripheral membrane ATP-binding proteins that couple energy to the active transport sys...

[ "GO:0015419", "GO:1902358", "GO:0016020" ]

[ "ABC-type sulfate transporter activity", "sulfate transmembrane transport", "membrane" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PANTHER", "NCBIFAM" ]

[ "PTHR30406", "TIGR00969" ]

[ "", "3a0106s02" ]

[ 21064, 18903 ]

2

[]

0

[]

0

[ "PUB00000042", "PUB00001137", "PUB00002368", "PUB00003831", "PUB00003865", "PUB00035343", "PUB00035344" ]

[ "3527048", "3000770", "2229036", "1738314", "7934906", "2188958", "7608089" ]

[ "Bacterial periplasmic transport systems: structure, mechanism, and evolution.", "Sequence of gene malG in E. coli K12: homologies between integral membrane components from binding protein-dependent transport systems.", "Binding protein-dependent transport systems.", "Membrane topology of the integral membran...

[ 1986, 1985, 1990, 1992, 1994, 1990, 1995 ]

7

[]

[ "IPR011865", "IPR011866" ]

0

2

0

[ "Archaea", "Bacteria", "Eukaryota", "metagenomes" ]

[ 265, 20391, 289, 125 ]

4

[ "Escherichia coli (strain K12)" ]

[ 2 ]

1

true

Family

Sulphate ABC transporter permease protein 2

Sulph_transpt2

5

IPR005668

5,668

2-isopropylmalate synthase

IPM_Synthase

Family

13,258

false

Alpha-isopropylmalate synthase ( ) catalyses the first step in the biosynthesis of leucine, the condensation of acetyl-CoA and alpha-ketoisovalerate to form 2-isopropylmalate synthase.

[ "GO:0003852", "GO:0009098" ]

[ "2-isopropylmalate synthase activity", "L-leucine biosynthetic process" ]

[ "molecular_function", "biological_process" ]

2

[ "HAMAP", "NCBIFAM" ]

[ "MF_00572", "TIGR00970" ]

[ "LeuA_type2", "leuA_yeast" ]

[ 13038, 11696 ]

2

[ "EC", "GP", "METACYC" ]

[ "2.3.3.13", "GenProp0164", "PWY-6871" ]

[ "EC:2.3.3.13", "GP:GenProp0164", "METACYC:PWY-6871" ]

3

[ "1sr9", "3fig", "3hps", "3hpx", "3hpz", "3hq1", "3u6w" ]

7

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 11424, 1620, 214 ]

3

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 2, 1 ]

3

true

Family

2-isopropylmalate synthase

IPM_Synthase

3

IPR005669

5,669

Thiosulphate/Sulfate-binding protein

Thiosulph/SO4-bd

Family

14,558

false

This entry represents thiosulfate/sulfate binding proteins. Sulfate binding protein (SBP) specifically binds sulfate [ ] and thiosulfate-binding protein (TSBP or CysP) specifically binds thiosulfate. They are involved in the ABC transport of sulfate and thiosulfate in eubacteria [ ]. This family are an example of type ...

[ "GO:0140104", "GO:1902358" ]

[ "molecular carrier activity", "sulfate transmembrane transport" ]

[ "molecular_function", "biological_process" ]

2

[ "PANTHER", "NCBIFAM", "CDD" ]

[ "PTHR30368", "TIGR00971", "cd01005" ]

[ "", "3a0106s03", "PBP2_CysP" ]

[ 14556, 13832, 12154 ]

3

[ "GP" ]

[ "GenProp0191" ]

[ "GP:GenProp0191" ]

1

[ "1sbp", "2hxw", "3fir", "3fj7", "3fjg", "3fjm", "4jb7", "5um2", "6ddn" ]

9

[ "PUB00035344", "PUB00056198", "PUB00061825" ]

[ "7608089", "11741199", "3885043" ]

[ "Sulfate and thiosulfate transport in Escherichia coli K-12: evidence for a functional overlapping of sulfate- and thiosulfate-binding proteins.", "The Venus flytrap of periplasmic binding proteins: an ancient protein module present in multiple drug receptors.", "Sulphate sequestered in the sulphate-binding pro...

[ 1995, 1999, 1985 ]

3

[]

0

null

[ "Bacteria", "Candidatus Heimdallarchaeum aukensis", "Eukaryota", "Sym plasmid", "metagenomes" ]

[ 14447, 1, 66, 1, 43 ]

5

[ "Escherichia coli (strain K12)" ]

[ 2 ]

1

true

Family

Thiosulphate/Sulfate-binding protein

Thiosulph/SO4-bd

4

IPR005670

5,670

Phosphate import ATP-binding protein PstB-like

PstB-like

Family

29,700

false

This entry includes a group of phosphate transport system permease proteins such as Phosphate import ATP-binding protein PstB and similar sequences mainly found in prokaryotes. They are membrane transport proteins that use the hydrolysis of ATP to function. They contain ABC (ATP-binding cassette-type) transporter domai...

[ "GO:0005315", "GO:0035435", "GO:0016020" ]

[ "phosphate transmembrane transporter activity", "phosphate ion transmembrane transport", "membrane" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "NCBIFAM", "CDD" ]

[ "TIGR00972", "cd03260" ]

[ "3a0107s01c2", "ABC_PstB_phosphate_transporter" ]

[ 25869, 29700 ]

2

[ "EC", "GP", "METACYC", "METACYC" ]

[ "7.3.2.1", "GenProp0190", "PWY-4621", "PWY-8264" ]

[ "EC:7.3.2.1", "GP:GenProp0190", "METACYC:PWY-4621", "METACYC:PWY-8264" ]

4

[]

0

[ "PUB00021096", "PUB00062379", "PUB00080861" ]

[ "9671506", "1447208", "8682808" ]

[ "Crystal structure of phosphate binding protein labeled with a coumarin fluorophore, a probe for inorganic phosphate.", "Mutational analysis of the Escherichia coli phosphate-specific transport system, a member of the traffic ATPase (or ABC) family of membrane transporters. A role for proline residues in transmem...

[ 1998, 1992, 1996 ]

3

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 1392, 27212, 658, 438 ]

4

[ "Arabidopsis thaliana", "Escherichia coli (strain K12)", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 3, 1, 3, 2 ]

4

true

Family

Phosphate import ATP-binding protein PstB-like

PstB-like

2

IPR005671

5,671

2-isopropylmalate synthase, bacterial-type

LeuA_bact_synth

Family

12,851

false

The branched-chain amino acids are synthesised by a common pathway that leads from pyruvate and alpha-ketobutyrate to valine and isoleucine, and a branch that leads from the immediate precursor of valine, alpha-ketoisovalerate, to leucine [ ]. This pathway operates in archaea, bacteria, fungi and plants, but not mammal...

[ "GO:0003852", "GO:0009098" ]

[ "2-isopropylmalate synthase activity", "L-leucine biosynthetic process" ]

[ "molecular_function", "biological_process" ]

2

[ "HAMAP", "NCBIFAM" ]

[ "MF_01025", "TIGR00973" ]

[ "LeuA_type1", "leuA_bact" ]

[ 12386, 12798 ]

2

[ "EC", "GP", "GP", "METACYC" ]

[ "2.3.3.13", "GenProp0164", "GenProp1405", "PWY-6871" ]

[ "EC:2.3.3.13", "GP:GenProp0164", "GP:GenProp1405", "METACYC:PWY-6871" ]

4

[]

0

[ "PUB00020847", "PUB00034699", "PUB00034700", "PUB00034701", "PUB00034702" ]

[ "15159544", "12626680", "4551511", "8117072", "8760908" ]

[ "Crystal structure of LeuA from Mycobacterium tuberculosis, a key enzyme in leucine biosynthesis.", "Leucine biosynthesis in fungi: entering metabolism through the back door.", "-isopropylmalate synthase from Salmonella typhimurium. Analysis of the guaternary structure and its relation to function.", "Leucine...

[ 2004, 2003, 1972, 1994, 1996 ]

5

[ "IPR050073" ]

[]

1

0

1

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 10, 11713, 959, 169 ]

4

[ "Arabidopsis thaliana", "Escherichia coli (strain K12)", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 8, 1, 5, 15 ]

4

true

Family

2-isopropylmalate synthase, bacterial-type

LeuA_bact_synth

8

IPR005672

5,672

Phosphate transport system permease protein PstA

Phosphate_PstA

Family

26,126

false

This entry describes PtsA, one of a pair of permease proteins in the ABC (high affinity) phosphate transporter [ ]. In a number of species, this permease is fused with the PtsC protein ( ). In Escherichia coli, this transport system is induced when the concentration of extrallular inorganic phosphate is low. A constitu...

[ "GO:0005315", "GO:0035435", "GO:0005886" ]

[ "phosphate transmembrane transporter activity", "phosphate ion transmembrane transport", "plasma membrane" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "NCBIFAM" ]

[ "TIGR00974" ]

[ "3a0107s02c" ]

[ 26126 ]

1

[ "GP" ]

[ "GenProp0190" ]

[ "GP:GenProp0190" ]

1

[]

0

[ "PUB00062379" ]

[ "1447208" ]

[ "Mutational analysis of the Escherichia coli phosphate-specific transport system, a member of the traffic ATPase (or ABC) family of membrane transporters. A role for proline residues in transmembrane helices." ]

[ 1992 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 994, 24697, 31, 404 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Phosphate transport system permease protein PstA

Phosphate_PstA

5

IPR005673

5,673

Phosphate ABC transporter, substrate-binding protein PstS

ABC_phos-bd_PstS

Family

13,520

false

PstS is the substrate-binding component of the ABC-type transporter complex pstSACB, involved in phosphate import. This protein is accompanied, generally in the same operon, by an ATP binding protein (pstB) and two permease proteins (pstC and pstA). The accumulation of this protein is enhanced under phosphate starvatio...

[ "GO:0042301", "GO:0035435", "GO:0043190" ]

[ "phosphate ion binding", "phosphate ion transmembrane transport", "ATP-binding cassette (ABC) transporter complex" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PIRSF", "NCBIFAM" ]

[ "PIRSF002756", "TIGR00975" ]

[ "PstS", "3a0107s03" ]

[ 13142, 12620 ]

2

[ "GP", "REACTOME" ]

[ "GenProp0190", "R-HSA-9637628" ]

[ "GP:GenProp0190", "REACTOME:R-HSA-9637628" ]

2

[ "1a40", "1a54", "1a55", "1ixg", "1ixh", "1ixi", "1oib", "1pbp", "1pc3", "1qui", "1quj", "1quk", "1qul", "2abh", "2q9t", "2z22", "4f18", "4f19", "4f1u", "4f1v", "4lvq", "5i84", "5wnn", "7dm1", "7dm2", "7xg7", "7xg8", "8ods" ]

28

[ "PUB00059292", "PUB00060971", "PUB00071925", "PUB00071938" ]

[ "18820899", "9139906", "18310026", "8003968" ]

[ "Stability of the pstS transcript of Escherichia coli.", "Three different putative phosphate transport receptors are encoded by the Mycobacterium tuberculosis genome and are present at the surface of Mycobacterium bovis BCG.", "Characterization of a Pseudomonas putida ABC transporter (AatJMQP) required for acid...

[ 2009, 1997, 2008, 1994 ]

4

[]

0

null

[ "Archaea", "Bacteria", "Caudoviricetes", "Eukaryota", "metagenomes" ]

[ 152, 13057, 36, 58, 217 ]

5

[ "Escherichia coli (strain K12)", "Homo sapiens" ]

[ 1, 1 ]

2

true

Family

Phosphate ABC transporter, substrate-binding protein PstS

ABC_phos-bd_PstS

2

IPR005674

5,674

CocE/Serine esterase

CocE/Ser_esterase

Family

22,771

false

This family includes the cocaine esterase CocE and several putative serine esterases. CocE from Rhodococcus hydrolyses cocaine to benzoate and ecgonine methyl ester, allowing this bacterium to use cocaine as the sole source of carbon and energy. The amino acid sequence of cocaine esterase has a region of similarity wit...

[ "GO:0016787" ]

[ "hydrolase activity" ]

[ "molecular_function" ]

1

[ "NCBIFAM" ]

[ "TIGR00976" ]

[ "CocE_NonD" ]

[ 22771 ]

1

[]

0

[ "1ju3", "1ju4", "1l7q", "1l7r", "1mpx", "1nx9", "1ryy", "2b4k", "2b9v", "3i2f", "3i2g", "3i2h", "3i2i", "3i2j", "3i2k", "3ib3", "3ida", "3iii", "3puh", "3pui", "4p08", "4pf1", "7f65", "9k48" ]

24

[ "PUB00055579" ]

[ "10698749" ]

[ "Gene cloning and nucleotide sequencing and properties of a cocaine esterase from Rhodococcus sp. strain MB1." ]

[ 2000 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Harvfovirus sp.", "unclassified sequences" ]

[ 177, 17642, 4631, 1, 320 ]

5

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)" ]

[ 2 ]

1

true

Family

CocE/Serine esterase

CocE/Ser_esterase

2

IPR005675

5,675

Citramalate synthase

Citramal_synthase

Family

7,200

false

(R)-citramalate synthase catalyses the condensation of pyruvate and acetyl-coenzyme A to form (R)-citramalate, the first dedicated step in the citramalate pathway. The citramalate pathway constitutes the main pathway for isoleucine biosynthesis in Geobacter sulfurreducens [ ].

[ "GO:0046912", "GO:0019752" ]

[ "acyltransferase activity, acyl groups converted into alkyl on transfer", "carboxylic acid metabolic process" ]

[ "molecular_function", "biological_process" ]

2

[ "PANTHER", "NCBIFAM" ]

[ "PTHR43538", "TIGR00977" ]

[ "", "citramal_synth" ]

[ 7200, 6705 ]

2

[ "EC", "METACYC" ]

[ "2.3.3.21", "PWY-5101" ]

[ "EC:2.3.3.21", "METACYC:PWY-5101" ]

2

[ "3dxi" ]

1

[ "PUB00074060" ]

[ "18245290" ]

[ "Elucidation of an alternate isoleucine biosynthesis pathway in Geobacter sulfurreducens." ]

[ 2008 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 120, 6583, 126, 371 ]

4

[ "Arabidopsis thaliana" ]

[ 1 ]

1

true

Family

Citramalate synthase

Citramal_synthase

6

IPR005676

5,676

Aspartate-semialdehyde dehydrogenase, peptidoglycan lacking

Asp_semi-ald_DH_pep-lack

Family

4,350

false

This entry represents the subgroup of aspartate dehydrogenases found primarily in organisms lacking peptidoglycan. In addition to its role in aspartate metabolism, the enzyme from Sulfolobus solfataricus has been shown recently to exhibit RNase activity, suggesting that these enzymes may perform additional cellular fun...

[ "GO:0050661" ]

[ "NADP binding" ]

[ "molecular_function" ]

1

[ "NCBIFAM" ]

[ "TIGR00978" ]

[ "asd_EA" ]

[ 4350 ]

1

[ "EC", "GP", "GP", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC" ]

[ "1.2.1.11", "GenProp0160", "GenProp1553", "PWY-2941", "PWY-2942", "PWY-5097", "PWY-6160", "PWY-6559", "PWY-6562", "PWY-7153", "PWY-7977", "PWY-8088", "PWY-8179", "PWY-8296" ]

[ "EC:1.2.1.11", "GP:GenProp0160", "GP:GenProp1553", "METACYC:PWY-2941", "METACYC:PWY-2942", "METACYC:PWY-5097", "METACYC:PWY-6160", "METACYC:PWY-6559", "METACYC:PWY-6562", "METACYC:PWY-7153", "METACYC:PWY-7977", "METACYC:PWY-8088", "METACYC:PWY-8179", "METACYC:PWY-8296" ]

14

[ "1ys4", "2ep5", "3hsk", "4dpk", "4dpl", "4dpm", "4zhs", "4zic", "5cef", "5jw6", "6c85", "6c8w" ]

12

[ "PUB00029242", "PUB00029661", "PUB00034673", "PUB00034674", "PUB00034675", "PUB00034754", "PUB00087881" ]

[ "14559965", "15272161", "1673060", "15388927", "16225889", "12359717", "17041055" ]

[ "Capture of an intermediate in the catalytic cycle of L-aspartate-beta-semialdehyde dehydrogenase.", "The role of substrate-binding groups in the mechanism of aspartate-beta-semialdehyde dehydrogenase.", "Chemical and kinetic mechanisms of aspartate-beta-semialdehyde dehydrogenase from Escherichia coli.", "Cr...

[ 2003, 2004, 1991, 2004, 2005, 2002, 2006 ]

7

[ "IPR012080" ]

[]

1

0

1

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 846, 1792, 1683, 29 ]

4

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 1, 1 ]

3

true

Family

Aspartate-semialdehyde dehydrogenase, peptidoglycan lacking

Asp_semi-ald_DH_pep-lack

6

IPR005678

5,678

Mitochondrial inner membrane translocase complex, subunit Tim17

Tim17

Family

895

false

The mitochondrial protein translocase (MPT) family, which brings nuclearly encoded preproteins into mitochondria, is very complex with 19 currently identified protein constituents. These proteins include several chaperone proteins, four proteins of the outer membrane translocase (Tom) import receptor, five proteins of ...

[ "GO:0008320", "GO:0030150", "GO:0005744" ]

[ "protein transmembrane transporter activity", "protein import into mitochondrial matrix", "TIM23 mitochondrial import inner membrane translocase complex" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "NCBIFAM" ]

[ "TIGR00980" ]

[ "3a0801so1tim17" ]

[ 895 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-1268020", "R-HSA-9837999", "R-SCE-1268020", "R-SPO-1268020" ]

[ "REACTOME:R-HSA-1268020", "REACTOME:R-HSA-9837999", "REACTOME:R-SCE-1268020", "REACTOME:R-SPO-1268020" ]

4

[ "8e1m", "8scx", "9j9b" ]

3

[ "PUB00014892" ]

[ "15232570" ]

[ "Mitochondrial import and the twin-pore translocase." ]

[ 2004 ]

1

[]

0

null

[ "Opisthokonta" ]

[ 895 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 1, 3, 5, 4, 1, 1 ]

7

true

Family

Mitochondrial inner membrane translocase complex, subunit Tim17

Tim17

2

IPR005679

5,679

Ribosomal protein uS12, bacteria

Ribosomal_uS12_bact

Family

44,686

false

Ribosomal protein uS12 is located at the interface of the large and small ribosomal subunits, where it plays an important role in both tRNA and ribosomal subunit interactions. uS12 is essential for maintenance of a pretranslocation state and, together with uS13, functions as a control element for the rRNA- and tRNA-dri...

[ "GO:0003735", "GO:0006412", "GO:0015935" ]

[ "structural constituent of ribosome", "translation", "small ribosomal subunit" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "HAMAP", "PRINTS", "NCBIFAM", "CDD" ]

[ "MF_00403_B", "PR01034", "TIGR00981", "cd03368" ]

[ "Ribosomal_uS12_B", "RIBOSOMALS12", "rpsL_bact", "Ribosomal_S12" ]

[ 37236, 44397, 43436, 43227 ]

4

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-5389840", "R-BTA-5419276", "R-BTA-9937383", "R-DME-5389840", "R-DME-5419276", "R-DME-9937383", "R-HSA-5368286", "R-HSA-5389840", "R-HSA-5419276", "R-HSA-9937383", "R-MMU-5389840", "R-MMU-5419276", "R-MMU-9937383" ]

[ "REACTOME:R-BTA-5389840", "REACTOME:R-BTA-5419276", "REACTOME:R-BTA-9937383", "REACTOME:R-DME-5389840", "REACTOME:R-DME-5419276", "REACTOME:R-DME-9937383", "REACTOME:R-HSA-5368286", "REACTOME:R-HSA-5389840", "REACTOME:R-HSA-5419276", "REACTOME:R-HSA-9937383", "REACTOME:R-MMU-5389840", "REACTOM...

13

[ "1fjg", "1hnw", "1hnx", "1hnz", "1hr0", "1i94", "1i95", "1i96", "1i97", "1ibk", "1ibl", "1ibm", "1j5e", "1jgo", "1jgp", "1jgq", "1mj1", "1ml5", "1mvr", "1n32", "1n33", "1n34", "1n36", "1pn7", "1pn8", "1qzc", "1vvj", "1vy4", "1vy5", "1vy6", "1vy7", "1xmo"...

1,291

[ "PUB00007068", "PUB00007069", "PUB00007070", "PUB00080220", "PUB00080222", "PUB00080224", "PUB00080228" ]

[ "11297922", "11290319", "11114498", "14536072", "15866943", "11863397", "11371156" ]

[ "Atomic structures at last: the ribosome in 2000.", "The ribosome in focus.", "The end of the beginning: structural studies of ribosomal proteins.", "Ribosomal proteins S12 and S13 function as control elements for translocation of the mRNA:tRNA complex.", "Severity of the streptomycin resistance and strepto...

[ 2001, 2001, 2000, 2003, 2005, 2002, 2001 ]

7

[ "IPR006032" ]

[]

1

0

1

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 172, 23199, 20888, 427 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus",...

[ 9, 1, 1, 3, 1, 1, 2, 1, 7, 3, 1, 1, 5 ]

13

true

Family

Ribosomal protein uS12, bacteria

Ribosomal_uS12_bact

8

IPR005680

5,680

Small ribosomal subunit protein uS12, eukaryota/archaea

Ribosomal_uS12_euk_arc

Family

5,929

false

Ribosomal protein uS12 is one of the proteins from the small ribosomal subunit. In Escherichia coli, uS12 is known to be involved in the translation initiation step. It is a very basic protein of 120 to 150 amino-acid residues. uS12 belongs to a family of ribosomal proteins which are grouped on the basis of sequence si...

[ "GO:0003735", "GO:0006412", "GO:0015935" ]

[ "structural constituent of ribosome", "translation", "small ribosomal subunit" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "NCBIFAM", "CDD" ]

[ "TIGR00982", "cd03367" ]

[ "uS12_E_A", "Ribosomal_S23" ]

[ 5842, 5790 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-156827", "R-BTA-1799339", "R-BTA-6791226", "R-BTA-72649", "R-BTA-72689", "R-BTA-72695", "R-BTA-72702", "R-BTA-72706", "R-BTA-9629569", "R-BTA-975956", "R-BTA-975957", "R-CEL-156827", "R-CEL-1799339", "R-CEL-72649", "R-CEL-72689", "R-CEL-72695", "R-CEL-72702", "R-CEL-72706", ...

[ "REACTOME:R-BTA-156827", "REACTOME:R-BTA-1799339", "REACTOME:R-BTA-6791226", "REACTOME:R-BTA-72649", "REACTOME:R-BTA-72689", "REACTOME:R-BTA-72695", "REACTOME:R-BTA-72702", "REACTOME:R-BTA-72706", "REACTOME:R-BTA-9629569", "REACTOME:R-BTA-975956", "REACTOME:R-BTA-975957", "REACTOME:R-CEL-15682...

100

[ "3j0l", "3j0o", "3j0p", "3j0q", "3j6x", "3j6y", "3j77", "3j78", "3j7a", "3j7p", "3j7r", "3j80", "3j81", "3jag", "3jah", "3jai", "3jaj", "3jam", "3jan", "3jap", "3jbn", "3jbo", "3jbp", "4bts", "4cxg", "4cxh", "4d5l", "4d61", "4kzx", "4kzy", "4kzz", "4u3m"...

642

[ "PUB00001551", "PUB00007068", "PUB00007069", "PUB00007070", "PUB00037574", "PUB00080890", "PUB00080891", "PUB00080892", "PUB00080893", "PUB00080894" ]

[ "3315748", "11297922", "11290319", "11114498", "14976550", "16077906", "12417019", "8037726", "2513185", "8529646" ]

[ "Primary structures of three highly acidic ribosomal proteins S6, S12 and S15 from the archaebacterium Halobacterium marismortui.", "Atomic structures at last: the ribosome in 2000.", "The ribosome in focus.", "The end of the beginning: structural studies of ribosomal proteins.", "Domain movements of elonga...

[ 1987, 2001, 2001, 2000, 2004, 2005, 2002, 1994, 1989, 1995 ]

10

[ "IPR006032" ]

[ "IPR022863" ]

1

0

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 886, 3, 5004, 36 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 7, 1, 1, 2, 3, 5, 1, 4, 5, 2, 2, 10 ]

12

true

Family

Small ribosomal subunit protein uS12, eukaryota/archaea

Ribosomal_uS12_euk_arc

6

IPR005681

5,681

Mitochondrial inner membrane translocase complex, subunit Tim23

Tim23

Family

958

false

The mitochondrial protein translocase (MPT) family, which brings nuclearly encoded preproteins into mitochondria, is very complex with 19 currently identified protein constituents. These proteins include several chaperone proteins, four proteins of the outer membrane translocase (Tom) import receptor, five proteins of ...

[ "GO:0008320", "GO:0030150", "GO:0005744" ]

[ "protein transmembrane transporter activity", "protein import into mitochondrial matrix", "TIM23 mitochondrial import inner membrane translocase complex" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "NCBIFAM" ]

[ "TIGR00983" ]

[ "3a0801s02tim23" ]

[ 958 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-1268020", "R-HSA-1268020", "R-SCE-1268020", "R-SPO-1268020", "R-XTR-1268020" ]

[ "REACTOME:R-BTA-1268020", "REACTOME:R-HSA-1268020", "REACTOME:R-SCE-1268020", "REACTOME:R-SPO-1268020", "REACTOME:R-XTR-1268020" ]

5

[ "7clv", "8e1m", "8scx", "9j9b" ]

4

[ "PUB00014892", "PUB00094556", "PUB00094558" ]

[ "15232570", "28301740", "29270408" ]

[ "Mitochondrial import and the twin-pore translocase.", "Mitochondrial Machineries for Protein Import and Assembly.", "Protein Translocation into the Intermembrane Space and Matrix of Mitochondria: Mechanisms and Driving Forces." ]

[ 2004, 2017, 2017 ]

3

[ "IPR045238" ]

[]

1

0

1

[ "Eukaryota" ]

[ 958 ]

1

[ "Arabidopsis thaliana", "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 3, 2, 4, 3, 5, 1, 1 ]

7

true

Family

Mitochondrial inner membrane translocase complex, subunit Tim23

Tim23

5

IPR005683

5,683

Mitochondrial import receptor subunit Tom22

Tom22

Family

4,017

false

The mitochondrial protein translocase family, which is responsible for movement of nuclear encoded pre-proteins into mitochondria, is very complex with at least 19 components. These proteins include several chaperone proteins, four proteins of the outer membrane translocase (Tom) import receptor, five proteins of the T...

[ "GO:0006886", "GO:0005741" ]

[ "intracellular protein transport", "mitochondrial outer membrane" ]

[ "biological_process", "cellular_component" ]

2

[ "PFAM", "PANTHER" ]

[ "PF04281", "PTHR12504" ]

[ "Tom22", "" ]

[ 3874, 3137 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-5205685", "R-HSA-1268020", "R-HSA-5205685", "R-MMU-5205685", "R-RNO-5205685" ]

[ "REACTOME:R-BTA-5205685", "REACTOME:R-HSA-1268020", "REACTOME:R-HSA-5205685", "REACTOME:R-MMU-5205685", "REACTOME:R-RNO-5205685" ]

5

[ "6jnf", "6ucu", "6ucv", "7ck6", "7cp9", "7vby", "7vc4", "7vd2", "7vdd", "8b4i", "8hco", "8w5j", "8w5k", "8xdn", "8xkw", "8xkx", "8xky", "8xva", "9eih", "9eii", "9eij", "9etm", "9i6b", "9i7p", "9i7s", "9i7t", "9j99", "9jxv" ]

28

[ "PUB00009931", "PUB00044318" ]

[ "11866524", "14699115" ]

[ "Protein translocase of the outer mitochondrial membrane: role of import receptors in the structural organization of the TOM complex.", "Mitochondrial import receptors Tom20 and Tom22 have chaperone-like activity." ]

[ 2002, 2004 ]

2

[]

[ "IPR020951" ]

0

1

0

[ "Eukaryota" ]

[ 4017 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 2, 1, 1, 2, 3, 3, 1, 8, 2, 1, 1, 3 ]

12

true

Family

Mitochondrial import receptor subunit Tom22

Tom22

7

IPR005684

5,684

Integration host factor, alpha subunit

IHF_alpha

Family

9,139

false

Integration host factor (IHF) is a heterodimeric protein consisting of alpha and beta ( ) subunits. IHF binds the minor groove of DNA in a sequence-specific manner to induce a large bend. This bending stabilises distinct DNA conformations that are required during several bacterial processes, such as recombination, tran...

[ "GO:0003677", "GO:0006310", "GO:0006355" ]

[ "DNA binding", "DNA recombination", "regulation of DNA-templated transcription" ]

[ "molecular_function", "biological_process", "biological_process" ]

3

[ "HAMAP", "NCBIFAM", "NCBIFAM", "CDD" ]

[ "MF_00380", "NF001401", "TIGR00987", "cd13835" ]

[ "IHF_alpha", "PRK00285.1", "himA", "IHF_A" ]

[ 8186, 8647, 7783, 9133 ]

4

[ "GP" ]

[ "GenProp1140" ]

[ "GP:GenProp1140" ]

1

[ "1ihf", "1ouz", "1owf", "1owg", "2ht0", "2iie", "2iif", "5j0n", "5wfe", "8flj", "9f0x", "9f0y", "9f0z", "9f10", "9f11", "9f12" ]

16

[ "PUB00003353", "PUB00014038", "PUB00014040", "PUB00022704", "PUB00036384", "PUB00079929", "PUB00079930", "PUB00079931", "PUB00079932", "PUB00079933", "PUB00079952", "PUB00104083" ]

[ "7500343", "12842466", "10993726", "7634092", "9757133", "15102446", "9032059", "9032076", "10089311", "9162504", "21716265", "11133949" ]

[ "Solution structure of the HU protein from Bacillus stearothermophilus.", "Integration host factor: putting a twist on protein-DNA recognition.", "Solution structure of a mutant of transcription factor 1: implications for enhanced DNA binding.", "Solution structure and DNA-binding properties of a thermostable...

[ 1995, 2003, 2000, 1994, 1998, 2004, 1997, 1997, 1999, 1997, 2011, 2001 ]

12

[ "IPR000119" ]

[]

1

0

1

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 2, 8985, 9, 143 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Integration host factor, alpha subunit

IHF_alpha

8

IPR005686

5,686

Mitochondrial import receptor subunit Tom40, fungi

Tom40_fungi

Family

33

false

Tom40 is a mitochondrion outer membrane protein and a component of the TOM (translocator of the outer mitochondrial membrane) complex, which is essential for import of protein precursors into mitochondria [ ]. In Saccharomyces cerevisiae, TOM complex is composed of the subunits Tom70, Tom40, Tom22, Tom20, Tom7, Tom6, a...

[ "GO:0008320", "GO:0030150", "GO:0005741" ]

[ "protein transmembrane transporter activity", "protein import into mitochondrial matrix", "mitochondrial outer membrane" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "NCBIFAM" ]

[ "TIGR00989" ]

[ "3a0801s07tom40" ]

[ 33 ]

1

[]

0

[ "5o8o", "6jnf", "6ucu", "6ucv", "7e4h", "7e4i", "7vku", "8b4i", "8hco", "8w5j", "8w5k", "8xkw", "8xkx", "8xky", "9j99" ]

15

[ "PUB00009931", "PUB00063454", "PUB00063483", "PUB00063484", "PUB00063485" ]

[ "11866524", "10427088", "1327874", "9774667", "14595396" ]

[ "Protein translocase of the outer mitochondrial membrane: role of import receptors in the structural organization of the TOM complex.", "Biogenesis of Tom40, core component of the TOM complex of mitochondria.", "Identification of the mitochondrial receptor complex in Saccharomyces cerevisiae.", "Preprotein tr...

[ 2002, 1999, 1992, 1998, 2003 ]

5

[ "IPR037930" ]

[]

1

0

1

[ "Ascomycota" ]

[ 33 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 1, 1 ]

3

true

Family

Mitochondrial import receptor subunit Tom40, fungi

Tom40_fungi

8

IPR005687

5,687

Mitochondrial outer membrane translocase complex, subunit Tom70

Tom70

Family

988

false

The mitochondrial protein translocase (MPT) family, which brings nuclearly encoded preproteins into mitochondria, is very complex with 19 currently identified protein constituents. These proteins include several chaperone proteins, four proteins of the outer membrane translocase (Tom) import receptor, five proteins of ...

[ "GO:0015450", "GO:0006886", "GO:0005741" ]

[ "protein-transporting ATPase activity", "intracellular protein transport", "mitochondrial outer membrane" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "NCBIFAM" ]

[ "TIGR00990" ]

[ "3a0801s09" ]

[ 988 ]

1

[]

0

[ "2gw1" ]

1

[]

0

[]

0

null

[ "Eukaryota" ]

[ 988 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)" ]

[ 1, 1 ]

2

true

Family

Mitochondrial outer membrane translocase complex, subunit Tom70

Tom70

5

IPR005689

5,689

Chloroplast envelope protein translocase, IAP75

IAP75

Family

481

false

Chloroplast function requires the import of nuclear encoded proteins from the cytoplasm across the chloroplast double membrane. This is accompished by two protein complexes, the Toc complex located at the outer membrane and the Tic complex loacted at the inner membrane [ ]. The Toc complex recognises specific proteins ...

[ "GO:0015450", "GO:0006886" ]

[ "protein-transporting ATPase activity", "intracellular protein transport" ]

[ "molecular_function", "biological_process" ]

2

[ "NCBIFAM" ]

[ "TIGR00992" ]

[ "3a0901s03IAP75" ]

[ 481 ]

1

[]

0

[]

0

[ "PUB00034696", "PUB00034698" ]

[ "11315189", "12124272" ]

[ "Molecular biology of chloroplast biogenesis: gene expression, protein import and intraorganellar sorting.", "The chloroplast protein import channel Toc75: pore properties and interaction with transit peptides." ]

[ 2001, 2002 ]

2

[ "IPR039910" ]

[]

1

0

1

[ "Magnoliopsida", "Synechocystis sp. (strain ATCC 27184 / PCC 6803 / Kazusa)" ]

[ 480, 1 ]

2

[ "Arabidopsis thaliana" ]

[ 4 ]

1

true

Family

Chloroplast envelope protein translocase, IAP75

IAP75

2

IPR005690

5,690

Translocase of chloroplast Toc86/159

Toc86_159

Family

2,073

false

This entry represents the translocase of chloroplast 159 family of proteins (Tocs), GTPases involved in protein precursor import into chloroplasts, which recognise chloroplast-destined precursor proteins and regulate their presentation to the translocation channel through GTP hydrolysis [ ]. They have three domains: th...

[ "GO:0003924", "GO:0005525", "GO:0045036", "GO:0009707" ]

[ "GTPase activity", "GTP binding", "protein targeting to chloroplast", "chloroplast outer membrane" ]

[ "molecular_function", "molecular_function", "biological_process", "cellular_component" ]

4

[ "NCBIFAM" ]

[ "TIGR00993" ]

[ "3a0901s04IAP86" ]

[ 2073 ]

1

[ "EC" ]

[ "3.6.5.-" ]

[ "EC:3.6.5.-" ]

1

[]

0

[ "PUB00007881", "PUB00095611" ]

[ "10712545", "15273297" ]

[ "Initial binding of preproteins involving the Toc159 receptor can be bypassed during protein import into chloroplasts.", "Functional specialization amongst the Arabidopsis Toc159 family of chloroplast protein import receptors." ]

[ 2000, 2004 ]

2

[ "IPR045058" ]

[]

1

0

1

[ "Streptophytina" ]

[ 2073 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 13, 11, 28 ]

3

true

Family

Translocase of chloroplast Toc86/159

Toc86_159

1

IPR005691

5,691

Chloroplast protein import component Tic20

Tic20

Family

3,174

false

Chloroplast function requires the import of nuclear encoded proteins from the cytoplasm across the chloroplast double membrane. This is accompished by two protein complexes, the Toc complex located at the outer membrane and the Tic complex loacted at the inner membrane [ ]. The Toc complex recognises specific proteins ...

[]

0

[ "PFAM", "PANTHER", "NCBIFAM" ]

[ "PF16166", "PTHR33510", "TIGR00994" ]

[ "TIC20", "", "3a0901s05TIC20" ]

[ 3137, 3081, 487 ]

3

[]

0

[ "7vcf", "7xzi", "8z9y" ]

3

[ "PUB00034696", "PUB00034697" ]

[ "11315189", "9817756" ]

[ "Molecular biology of chloroplast biogenesis: gene expression, protein import and intraorganellar sorting.", "Tic20 and Tic22 are new components of the protein import apparatus at the chloroplast inner envelope membrane." ]

[ 2001, 1998 ]

2

[]

0

null

[ "Bacillati", "Eukaryota" ]

[ 383, 2791 ]

2

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 17, 9, 15 ]

3

true

Family

Chloroplast protein import component Tic20

Tic20

9

IPR005692

5,692

Chloroplast protein import component Tic22

Tic22

Family

33

false

Chloroplast function requires the import of nuclear encoded proteins from the cytoplasm across the chloroplast double membrane. This is accompished by two protein complexes, the Toc complex located at the outer membrane and the Tic complex loacted at the inner membrane [ ]. The Toc complex recognises specific proteins ...

[]

0

[ "NCBIFAM" ]

[ "TIGR00995" ]

[ "3a0901s06TIC22" ]

[ 33 ]

1

[]

0

[]

0

[ "PUB00034696", "PUB00087188" ]

[ "11315189", "25174336" ]

[ "Molecular biology of chloroplast biogenesis: gene expression, protein import and intraorganellar sorting.", "New insights into the mechanism of chloroplast protein import and its integration with protein quality control, organelle biogenesis and development." ]

[ 2001, 2015 ]

2

[ "IPR007378" ]

[]

1

0

1

[ "Synechocystis sp. (strain ATCC 27184 / PCC 6803 / Kazusa)", "rosids" ]

[ 1, 32 ]

2

[ "Arabidopsis thaliana" ]

[ 2 ]

1

true

Family

Chloroplast protein import component Tic22

Tic22

3

IPR005693

5,693

Virulence factor Mce protein

Mce

Family

32,038

false

The members of this family represent the protein products of all 24 genes associated with the four mammalian cell entry operons of Mycobacterium tuberculosis and their homologues in other Actinomycetales [ ], including Lipoprotein LprN from M.tuberculosis. LprN stimulates the host (mouse) immune response. Previously se...

[]

0

[ "PRINTS", "NCBIFAM" ]

[ "PR01782", "TIGR00996" ]

[ "MCEVIRFACTOR", "Mtu_fam_mce" ]

[ 4530, 32000 ]

2

[]

0

[ "8fed", "8fee", "8fef" ]

3

[ "PUB00007714", "PUB00011682", "PUB00011684", "PUB00015052", "PUB00056058", "PUB00106861" ]

[ "10694977", "11298648", "12052567", "14500535", "21258845", "24989028" ]

[ "Analysis of the proteome of Mycobacterium tuberculosis in silico.", "Recombinant Mycobacterium tuberculosis protein associated with mammalian cell entry.", "Mycobacterium tuberculosis mammalian cell entry operon (mce) homologs in Mycobacterium other than tuberculosis (MOTT).", "Analysis of expression profile...

[ 1999, 2001, 2002, 2003, 2011, 2014 ]

6

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 31998, 3, 37 ]

3

[]

0

true

Family

Virulence factor Mce protein

Mce

9

IPR005694

5,694

Membrane fusion proteins, proteobacteria

MFP_proteobact

Family

2,022

false

This family of membrane fusion proteins (MFP) from proteobacteria includes Multidrug resistance protein MdtN and the efflux pump membrane proteins EmrA and EmrK [ ]. MdtN is thought to be involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride. The EmrAB transporter confer resistance to carbon...

[ "GO:0042910", "GO:1990961" ]

[ "xenobiotic transmembrane transporter activity", "xenobiotic detoxification by transmembrane export across the plasma membrane" ]

[ "molecular_function", "biological_process" ]

2

[ "NCBIFAM" ]

[ "TIGR00998" ]

[ "8a0101" ]

[ 2022 ]

1

[]

0

[ "4tko", "8zal", "8zar" ]

3

[ "PUB00002268", "PUB00092685", "PUB00092686" ]

[ "7730261", "12501312", "12482849" ]

[ "EmrR is a negative regulator of the Escherichia coli multidrug resistance pump EmrAB.", "Growth phase-dependent transcription of emrKY, a homolog of multidrug efflux emrAB genes of Escherichia coli, is induced by tetracycline.", "Identification of oligomerization and drug-binding domains of the membrane fusion...

[ 1995, 1997, 2003 ]

3

[]

0

null

[ "Bacteria", "Opisthokonta", "plant metagenome" ]

[ 2016, 3, 3 ]

3

[ "Escherichia coli (strain K12)" ]

[ 3 ]

1

true

Family

Membrane fusion proteins, proteobacteria

MFP_proteobact

5

IPR005695

5,695

Cobalt/zinc/cadmium resistance protein CzcB-like

Co/Zn/Cd_resistance_CzcB-like

Family

25

false

Gram-negative bacteria have evolved transport complexes that export macromolecules and toxic substances such as heavy metals across the two membranes of the cell envelope in a single energy coupled step. The process requires (1) a cytoplasmic membrane export system, (2) a membrane fusion protein (MFP), and (3) an outer...

[ "GO:0046873", "GO:0030001" ]

[ "metal ion transmembrane transporter activity", "metal ion transport" ]

[ "molecular_function", "biological_process" ]

2

[ "NCBIFAM" ]

[ "TIGR00999" ]

[ "8a0102" ]

[ 25 ]

1

[]

0

[]

0

[]

0

[ "IPR006143" ]

[]

1

0

1

[ "Pseudomonadati" ]

[ 25 ]

1

[]

0

true

Family

Cobalt/zinc/cadmium resistance protein CzcB-like

Co/Zn/Cd_resistance_CzcB-like

9

IPR005696

5,696

Secretion protein MesE/LcnD

MesE/LcnD

Family

620

false

Bacteriocins are antibacterial proteinaceous compounds produced by bacteria. In Gram-positive bacteria, they are divided into four classes. Within the class II, constituted by non-modified peptides produced mainly by lactic acid bacteria, bacteriocins of the subclass IIa (also known as pediocin-like bacteriocins), such...

[]

0

[ "NCBIFAM" ]

[ "TIGR01000" ]

[ "bacteriocin_acc" ]

[ 620 ]

1

[]

0

[]

0

[ "PUB00034682", "PUB00087441", "PUB00087450", "PUB00087451" ]

[ "16205711", "7551032", "15019729", "11731132" ]

[ "Bacteriocins: developing innate immunity for food.", "Mesentericin Y105 gene clusters in Leuconostoc mesenteroides Y105.", "Differences in mesentericin secretion systems from two Leuconostoc strains.", "Proteins of the lactococcin A secretion system: lcnD encodes two in-frame proteins." ]

[ 2005, 1995, 2004, 2001 ]

4

[]

0

null

[ "Bacteria" ]

[ 620 ]

1

[]

0

true

Family

Secretion protein MesE/LcnD

MesE/LcnD

7

IPR005697

5,697

Homoserine O-succinyltransferase MetA

HST_MetA

Family

1,808

false

This family of enzymes, homoserine O-succinyltransferase, catalyses the first step in the biosynthesis of methionine: Succinyl-CoA + L-homoserine = CoA + O-succinyl-L-homoserine These enzymes are found in gammaproteobacteria, and are essential for its survival. Since they are not found in humans, they make a promising ...

[ "GO:0008899", "GO:0019281", "GO:0005737" ]

[ "homoserine O-succinyltransferase activity", "L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine", "cytoplasm" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "NCBIFAM" ]

[ "TIGR01001" ]

[ "MetA_succinyl" ]

[ 1808 ]

1

[ "EC", "GP", "GP", "GP" ]

[ "2.3.1.46", "GenProp1419", "GenProp1475", "GenProp1581" ]

[ "EC:2.3.1.46", "GP:GenProp1419", "GP:GenProp1475", "GP:GenProp1581" ]

4

[ "6mtg", "7cbe" ]

2

[ "PUB00043346" ]

[ "17442255" ]

[ "Assessing the roles of essential functional groups in the mechanism of homoserine succinyltransferase." ]

[ 2007 ]

1

[ "IPR033752" ]

[]

1

0

1

[ "Bacteria" ]

[ 1808 ]

1

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Homoserine O-succinyltransferase MetA

HST_MetA

5

IPR005699

5,699

Chaperone lipoprotein, PulS/OutS

Chap_lipoprot_PulS/OutS

Family

294

false

This family comprises lipoproteins from gamma proteobacterial species: pullulanase secretion protein PulS protein of Klebsiella pneumoniae ( ), the lipoprotein OutS protein of Erwinia chrysanthemi ( ) and the functionally uncharacterised type II secretion protein EtpO ( ) from Escherichia coli O157:H7. PulS and OutS ha...

[ "GO:0006886" ]

[ "intracellular protein transport" ]

[ "biological_process" ]

1

[ "NCBIFAM" ]

[ "TIGR01004" ]

[ "PulS_OutS" ]

[ 294 ]

1

[]

0

[ "3sol", "3utk", "4a56", "4k0u", "6hcg" ]

5

[ "PUB00097456" ]

[ "22098633" ]

[ "Pilotin-secretin recognition in the type II secretion system of Klebsiella oxytoca." ]

[ 2011 ]

1

[ "IPR019114" ]

[]

1

0

1

[ "Enterobacterales" ]

[ 294 ]

1

[]

0

true

Family

Chaperone lipoprotein, PulS/OutS

Chap_lipoprot_PulS/OutS

7

IPR005700

5,700

Exopolysaccharide biosynthesis protein ExoP-like

EPS_ExoP-like

Family

1,547

false

This group of proteins are part of a large genetic locus which is associated with exopolysaccharide (EPS) biosynthesis [ , ]. This entry includes ExoP from Rhizobium meliloti and PssP from Rhizobium leguminosarum bv. trifolii. They belong to the PCP2a family involved in the synthesis of high-molecular-weight EPS [ ]. T...

[]

0

[ "NCBIFAM" ]

[ "TIGR01005" ]

[ "eps_transp_fam" ]

[ 1547 ]

1

[]

0

[]

0

[ "PUB00017617", "PUB00088289", "PUB00088290", "PUB00088291" ]

[ "7476194", "7565082", "11489870", "12026178" ]

[ "Molecular characterization of the eps gene cluster of Pseudomonas solanacearum and its transcriptional regulation at a single promoter.", "Low-molecular-weight succinoglycan is predominantly produced by Rhizobium meliloti strains carrying a mutated ExoP protein characterized by a periplasmic N-terminal domain an...

[ 1995, 1995, 2001, 2002 ]

4

[]

0

null

[ "Bacteria" ]

[ 1547 ]

1

[]

0

true

Family

Exopolysaccharide biosynthesis protein ExoP-like

EPS_ExoP-like

9

IPR005702

5,702

Tyrosine-protein kinase Wzc-like, C-terminal domain

Wzc-like_C

Domain

32,094

false

This entry represents the C-terminal domain of Tyrosine-protein kinase wzc from Escherichia coli and similar bacterial sequences. Wzc in required for the extracellular polysaccharide colanic acid synthesis. It is probably involved in the export of colanic acid from the cell to medium [ ]. This domain covers the whole l...

[]

0

[ "NCBIFAM", "CDD" ]

[ "TIGR01007", "cd05387" ]

[ "eps_fam", "BY-kinase" ]

[ 25757, 32085 ]

2

[ "EC" ]

[ "2.7.10" ]

[ "EC:2.7.10" ]

1

[ "2ved", "3bfv", "3cio", "3la6", "4jlv", "4jmp", "6u1q", "6z0p", "7nhr", "7nhs", "7ni2", "7nib", "7nih", "7nii", "9exo", "9exp", "9exq", "9exr", "9i2q", "9i2r" ]

20

[ "PUB00013952", "PUB00049699", "PUB00070730", "PUB00104565", "PUB00106862", "PUB00143002", "PUB00143003", "PUB00143004", "PUB00143005", "PUB00143006", "PUB00143007", "PUB00143008" ]

[ "11916378", "18547145", "10760144", "12851388", "11027683", "11751920", "10069388", "9434192", "15941992", "7960118", "19525115", "22889913" ]

[ "Classification and evolution of P-loop GTPases and related ATPases.", "Structural basis for the regulation mechanism of the tyrosine kinase CapB from Staphylococcus aureus.", "Tyrosine phosphorylation of CpsD negatively regulates capsular polysaccharide biosynthesis in streptococcus pneumoniae.", "Autophosph...

[ 2002, 2008, 2000, 2003, 2001, 2002, 1999, 1997, 2005, 1994, 2009, 2012 ]

12

[ "IPR025669" ]

[]

1

0

1

[ "Bacteria", "Eukaryota", "Inoviridae sp. ctDEu7", "unclassified sequences" ]

[ 31771, 23, 1, 299 ]

4

[ "Escherichia coli (strain K12)" ]

[ 2 ]

1

true

Domain

Tyrosine-protein kinase Wzc-like, C-terminal domain

Wzc-like_C

8

IPR005703

5,703

Small ribosomal subunit protein uS3, eukaryota/archaeal

Ribosomal_uS3_euk_arc

Family

6,362

false

Ribosomal protein uS3 is one of the proteins from the small ribosomal subunit. This family describes ribosomal protein uS3 found in eukaryotes and in archaea. Ribosomes are the particles that catalyse mRNA-directed protein synthesis in all organisms. The codons of the mRNA are exposed on the ribosome to allow tRNA bind...

[ "GO:0003735", "GO:0006412", "GO:0015935" ]

[ "structural constituent of ribosome", "translation", "small ribosomal subunit" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "NCBIFAM" ]

[ "TIGR01008" ]

[ "uS3_euk_arch" ]

[ 6362 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-156827", "R-BTA-1799339", "R-BTA-6791226", "R-BTA-72649", "R-BTA-72689", "R-BTA-72695", "R-BTA-72702", "R-BTA-72706", "R-BTA-975956", "R-BTA-975957", "R-CEL-156827", "R-CEL-1799339", "R-CEL-72649", "R-CEL-72689", "R-CEL-72695", "R-CEL-72702", "R-CEL-72706", "R-CEL-975956", ...

[ "REACTOME:R-BTA-156827", "REACTOME:R-BTA-1799339", "REACTOME:R-BTA-6791226", "REACTOME:R-BTA-72649", "REACTOME:R-BTA-72689", "REACTOME:R-BTA-72695", "REACTOME:R-BTA-72702", "REACTOME:R-BTA-72706", "REACTOME:R-BTA-975956", "REACTOME:R-BTA-975957", "REACTOME:R-CEL-156827", "REACTOME:R-CEL-179933...

110

[ "3j6x", "3j6y", "3j77", "3j78", "3j7a", "3j7p", "3j7r", "3j80", "3j81", "3jag", "3jah", "3jai", "3jaj", "3jam", "3jan", "3jap", "3jbn", "3jbo", "3jbp", "4bsz", "4bts", "4d5l", "4d61", "4kzx", "4kzy", "4kzz", "4u3m", "4u3n", "4u3u", "4u4n", "4u4o", "4u4q"...

556

[ "PUB00007068", "PUB00007069", "PUB00007070" ]

[ "11297922", "11290319", "11114498" ]

[ "Atomic structures at last: the ribosome in 2000.", "The ribosome in focus.", "The end of the beginning: structural studies of ribosomal proteins." ]

[ 2001, 2001, 2000 ]

3

[ "IPR057258" ]

[ "IPR027488" ]

1

0

[ "Archaea", "Eukaryota", "unclassified sequences" ]

[ 934, 5342, 86 ]

3

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 7, 1, 1, 3, 3, 7, 1, 5, 10, 1, 1, 10 ]

12

true

Family

Small ribosomal subunit protein uS3, eukaryota/archaeal

Ribosomal_uS3_euk_arc

1

IPR005704

5,704

Small ribosomal subunit protein uS3, bacteria

Ribosomal_uS3_bact

Family

39,782

false

Ribosomal protein uS3 is one of the proteins from the small ribosomal subunit. This family describes the bacterial type of ribosomal protein uS3 and also and many chloroplast forms. Chloroplast and mitochondrial forms have large, variable inserts between conserved N-terminal and C-terminal domains. Ribosomes are the pa...

[ "GO:0003735", "GO:0006412" ]

[ "structural constituent of ribosome", "translation" ]

[ "molecular_function", "biological_process" ]

2

[ "HAMAP", "NCBIFAM" ]

[ "MF_01309_B", "TIGR01009" ]

[ "Ribosomal_uS3_B", "rpsC_bact" ]

[ 38825, 39744 ]

2

[]

0

[ "1fjg", "1hnw", "1hnx", "1hnz", "1hr0", "1i94", "1i95", "1i96", "1i97", "1ibk", "1ibl", "1ibm", "1j5e", "1jgo", "1jgp", "1jgq", "1ml5", "1n32", "1n33", "1n34", "1n36", "1vvj", "1vy4", "1vy5", "1vy6", "1vy7", "1xmo", "1xmq", "1xnq", "1xnr", "2e5l", "2f4v"...

1,163

[ "PUB00007068", "PUB00007069", "PUB00007070" ]

[ "11297922", "11290319", "11114498" ]

[ "Atomic structures at last: the ribosome in 2000.", "The ribosome in focus.", "The end of the beginning: structural studies of ribosomal proteins." ]

[ 2001, 2001, 2000 ]

3

[ "IPR057258" ]

[]

1

0

1

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 24188, 14976, 618 ]

3

[ "Arabidopsis thaliana", "Escherichia coli (strain K12)", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 5, 1, 3, 6 ]

4

true

Family

Small ribosomal subunit protein uS3, bacteria

Ribosomal_uS3_bact

1

IPR005705

5,705

Polysaccharide export inner-membrane protein, BexC/CtrB/KpsE/VexD

BexC_CtrB_KpsE_VexD

Family

246

false

This family contains gammaproteobacterial proteins involved in ATP-dependent capsule polysaccharide export [ , ].

[ "GO:0005351", "GO:0015774", "GO:0009276" ]

[ "carbohydrate:proton symporter activity", "polysaccharide transport", "Gram-negative-bacterium-type cell wall" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "NCBIFAM" ]

[ "TIGR01010" ]

[ "BexC_CtrB_KpsE" ]

[ 246 ]

1

[]

0

[]

0

[ "PUB00007882", "PUB00007883" ]

[ "1856162", "2082145" ]

[ "Identification of two genes, kpsM and kpsT, in region 3 of the polysialic acid gene cluster of Escherichia coli K1.", "The bex locus in encapsulated Haemophilus influenzae: a chromosomal region involved in capsule polysaccharide export." ]

[ 1991, 1990 ]

2

[]

0

null

[ "Pseudomonadota" ]

[ 246 ]

1

[]

0

true

Family

Polysaccharide export inner-membrane protein, BexC/CtrB/KpsE/VexD

BexC_CtrB_KpsE_VexD

2

IPR005706

5,706

Small ribosomal subunit protein uS2, bacteria/mitochondria/plastid

Ribosomal_uS2_bac/mit/plastid

Family

44,504

false

This family describes the bacterial, archaea, mitochondrial and chloroplast forms of ribosomal protein uS2. Ribosomes are the particles that catalyse mRNA-directed protein synthesis in all organisms. The codons of the mRNA are exposed on the ribosome to allow tRNA binding. This leads to the incorporation of amino acids...

[ "GO:0003735", "GO:0006412", "GO:0015935" ]

[ "structural constituent of ribosome", "translation", "small ribosomal subunit" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "HAMAP", "PANTHER", "NCBIFAM" ]

[ "MF_00291_B", "PTHR12534", "TIGR01011" ]

[ "Ribosomal_uS2_B", "", "rpsB_bact" ]

[ 43039, 44142, 41908 ]

3

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-5389840", "R-BTA-5419276", "R-BTA-9837999", "R-BTA-9937383", "R-DDI-9837999", "R-HSA-5368286", "R-HSA-5389840", "R-HSA-5419276", "R-HSA-9837999", "R-HSA-9937383", "R-MMU-5389840", "R-MMU-5419276", "R-MMU-9837999", "R-MMU-9937383", "R-SCE-9837999", "R-SPO-9837999" ]

[ "REACTOME:R-BTA-5389840", "REACTOME:R-BTA-5419276", "REACTOME:R-BTA-9837999", "REACTOME:R-BTA-9937383", "REACTOME:R-DDI-9837999", "REACTOME:R-HSA-5368286", "REACTOME:R-HSA-5389840", "REACTOME:R-HSA-5419276", "REACTOME:R-HSA-9837999", "REACTOME:R-HSA-9937383", "REACTOME:R-MMU-5389840", "REACTOM...

16

[ "1fjg", "1hnw", "1hnx", "1hnz", "1hr0", "1i94", "1i95", "1i96", "1i97", "1ibk", "1ibl", "1ibm", "1j5e", "1jgo", "1jgp", "1jgq", "1ml5", "1n32", "1n33", "1n34", "1n36", "1vi5", "1vi6", "1vvj", "1vy4", "1vy5", "1vy6", "1vy7", "1x18", "1xmo", "1xmq", "1xnq"...

1,220

[ "PUB00007068", "PUB00007069", "PUB00007070" ]

[ "11297922", "11290319", "11114498" ]

[ "Atomic structures at last: the ribosome in 2000.", "The ribosome in focus.", "The end of the beginning: structural studies of ribosomal proteins." ]

[ 2001, 2001, 2000 ]

3

[ "IPR001865" ]

[]

1

0

1

[ "Archaea", "Bacteria", "Eukaryota", "Myoviridae sp. ct2th6", "unclassified sequences" ]

[ 25, 24426, 19465, 1, 587 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus",...

[ 8, 1, 1, 1, 1, 3, 2, 1, 8, 4, 1, 1, 15 ]

13

true

Family

Small ribosomal subunit protein uS2, bacteria/mitochondria/plastid

Ribosomal_uS2_bac/mit/plastid

9

IPR005707

5,707

Small ribosomal subunit protein uS2, eukaryota/archaea

Ribosomal_uS2_euk_arc

Family

8,275

false

This family includes the small ribosomal subunit protein uS2 from archaea and cytosolic uS2 from eukaryotes. Ribosomes are the particles that catalyse mRNA-directed protein synthesis in all organisms. The codons of the mRNA are exposed on the ribosome to allow tRNA binding. This leads to the incorporation of amino acid...

[ "GO:0003735", "GO:0006412", "GO:0015935" ]

[ "structural constituent of ribosome", "translation", "small ribosomal subunit" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PANTHER", "NCBIFAM" ]

[ "PTHR11489", "TIGR01012" ]

[ "", "uS2_euk_arch" ]

[ 8251, 6766 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-156827", "R-BTA-1799339", "R-BTA-6791226", "R-BTA-72649", "R-BTA-72689", "R-BTA-72695", "R-BTA-72702", "R-BTA-72706", "R-BTA-975956", "R-BTA-975957", "R-CEL-156827", "R-CEL-1799339", "R-CEL-72649", "R-CEL-72689", "R-CEL-72695", "R-CEL-72702", "R-CEL-72706", "R-CEL-975956", ...

[ "REACTOME:R-BTA-156827", "REACTOME:R-BTA-1799339", "REACTOME:R-BTA-6791226", "REACTOME:R-BTA-72649", "REACTOME:R-BTA-72689", "REACTOME:R-BTA-72695", "REACTOME:R-BTA-72702", "REACTOME:R-BTA-72706", "REACTOME:R-BTA-975956", "REACTOME:R-BTA-975957", "REACTOME:R-CEL-156827", "REACTOME:R-CEL-179933...

133

[ "1vi5", "1vi6", "3bch", "3j6x", "3j6y", "3j77", "3j78", "3j7a", "3j7p", "3j7r", "3j80", "3j81", "3jag", "3jah", "3jai", "3jaj", "3jam", "3jan", "3jap", "3jbn", "3jbo", "3jbp", "4bts", "4d5l", "4d61", "4kzx", "4kzy", "4kzz", "4u3m", "4u3n", "4u3u", "4u4n"...

575

[ "PUB00007068", "PUB00007069", "PUB00007070" ]

[ "11297922", "11290319", "11114498" ]

[ "Atomic structures at last: the ribosome in 2000.", "The ribosome in focus.", "The end of the beginning: structural studies of ribosomal proteins." ]

[ 2001, 2001, 2000 ]

3

[ "IPR001865" ]

[ "IPR023454", "IPR027498" ]

1

2

0

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 897, 9, 7326, 43 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 9, 1, 2, 2, 10, 4, 1, 10, 14, 2, 2, 34 ]

12

true

Family

Small ribosomal subunit protein uS2, eukaryota/archaea

Ribosomal_uS2_euk_arc

8

IPR005708

5,708

Homogentisate 1,2-dioxygenase

Homogentis_dOase

Family

16,596

false

Alkaptonuria (AKU), a rare hereditary disorder, was the first disease to be interpreted as an inborn error of metabolism. The deficiency causes homogentisic aciduria, ochronosis, and arthritis. AKU patients are deficient for homogentisate 1,2 dioxygenase (HGD) ( ), the enzyme that mediates the conversion of homogentisa...

[ "GO:0004411", "GO:0006559", "GO:0006570" ]

[ "homogentisate 1,2-dioxygenase activity", "L-phenylalanine catabolic process", "tyrosine metabolic process" ]

[ "molecular_function", "biological_process", "biological_process" ]

3

[ "PANTHER", "NCBIFAM" ]

[ "PTHR11056", "TIGR01015" ]

[ "", "hmgA" ]

[ 16587, 9410 ]

2

[ "EC", "GP", "GP", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "1.13.11.5", "GenProp0139", "GenProp1375", "R-CEL-8963684", "R-DDI-8963684", "R-DME-8963684", "R-HSA-8963684", "R-MMU-8963684" ]

[ "EC:1.13.11.5", "GP:GenProp0139", "GP:GenProp1375", "REACTOME:R-CEL-8963684", "REACTOME:R-DDI-8963684", "REACTOME:R-DME-8963684", "REACTOME:R-HSA-8963684", "REACTOME:R-MMU-8963684" ]

8

[ "1ey2", "1eyb", "3zds", "4aq2", "4aq6" ]

5

[ "PUB00009903", "PUB00101169" ]

[ "10876237", "8782815" ]

[ "Crystal structure of human homogentisate dioxygenase.", "The molecular basis of alkaptonuria." ]

[ 2000, 1996 ]

2

[]

[ "IPR022950" ]

0

1

0

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 44, 10141, 6306, 105 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 3, 1, 1, 1, 7, 3, 1, 2, 8, 10 ]

10

true

Family

Homogentisate 1,2-dioxygenase

Homogentis_dOase

7

IPR005709

5,709

Small ribosomal subunit protein uS4, bacteria

Ribosomal_uS4_bact

Family

49,594

false

Ribosomal protein uS4, is one of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit. This entry consists of organelle (chloroplast and mitochondrial) ribosomal protein uS4 as well as bacterial. Ribosomes are the particles that catalyse mRNA-direct...

[ "GO:0003735", "GO:0006412", "GO:0015935" ]

[ "structural constituent of ribosome", "translation", "small ribosomal subunit" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "HAMAP", "NCBIFAM" ]

[ "MF_01306_B", "TIGR01017" ]

[ "Ribosomal_uS4_B", "rpsD_bact" ]

[ 49308, 46986 ]

2

[]

0

[ "1c05", "1c06", "1eg0", "1fjg", "1fka", "1hnw", "1hnx", "1hnz", "1hr0", "1i94", "1i95", "1i96", "1i97", "1ibk", "1ibl", "1ibm", "1j5e", "1jgo", "1jgp", "1jgq", "1ml5", "1n32", "1n33", "1n34", "1n36", "1qd7", "1vvj", "1vy4", "1vy5", "1vy6", "1vy7", "1xmo"...

1,179

[ "PUB00007068", "PUB00007069", "PUB00007070" ]

[ "11297922", "11290319", "11114498" ]

[ "Atomic structures at last: the ribosome in 2000.", "The ribosome in focus.", "The end of the beginning: structural studies of ribosomal proteins." ]

[ 2001, 2001, 2000 ]

3

[ "IPR022801" ]

[]

1

0

1

[ "Bacteria", "Eukaryota", "Siphoviridae sp. ctNZc11", "candidate division MSBL1 archaeon SCGC-AAA382N08", "unclassified sequences" ]

[ 24817, 24338, 1, 1, 437 ]

5

[ "Arabidopsis thaliana", "Escherichia coli (strain K12)", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 4, 1, 2, 4 ]

4

true

Family

Small ribosomal subunit protein uS4, bacteria

Ribosomal_uS4_bact

1

IPR005710

5,710

Small ribosomal subunit protein uS4, eukaryota/archaea

Ribosomal_uS4_euk_arc

Family

6,557

false

This entry represents the uS4 protein, found in eukaryotes and archaea, that is a component of the small ribosomal subunit. Previously, the eukaryotic ribosomal proteins were known as S9. Ribosomes are the particles that catalyse mRNA-directed protein synthesis in all organisms. The codons of the mRNA are exposed on th...

[ "GO:0003735", "GO:0006412", "GO:0015935" ]

[ "structural constituent of ribosome", "translation", "small ribosomal subunit" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "NCBIFAM" ]

[ "TIGR01018" ]

[ "uS4_arch" ]

[ 6557 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-156827", "R-BTA-1799339", "R-BTA-6791226", "R-BTA-72649", "R-BTA-72689", "R-BTA-72695", "R-BTA-72702", "R-BTA-72706", "R-BTA-975956", "R-BTA-975957", "R-CEL-156827", "R-CEL-1799339", "R-CEL-6791226", "R-CEL-72649", "R-CEL-72689", "R-CEL-72695", "R-CEL-72702", "R-CEL-72706", ...

[ "REACTOME:R-BTA-156827", "REACTOME:R-BTA-1799339", "REACTOME:R-BTA-6791226", "REACTOME:R-BTA-72649", "REACTOME:R-BTA-72689", "REACTOME:R-BTA-72695", "REACTOME:R-BTA-72702", "REACTOME:R-BTA-72706", "REACTOME:R-BTA-975956", "REACTOME:R-BTA-975957", "REACTOME:R-CEL-156827", "REACTOME:R-CEL-179933...

98

[ "3j6x", "3j6y", "3j77", "3j78", "3j7a", "3j7p", "3j7r", "3j80", "3j81", "3jag", "3jah", "3jai", "3jaj", "3jam", "3jan", "3jap", "3jbn", "3jbo", "3jbp", "4bts", "4d5l", "4d61", "4kzx", "4kzy", "4kzz", "4u3m", "4u3n", "4u3u", "4u4n", "4u4o", "4u4q", "4u4r"...

636

[ "PUB00007068", "PUB00007069", "PUB00007070" ]

[ "11297922", "11290319", "11114498" ]

[ "Atomic structures at last: the ribosome in 2000.", "The ribosome in focus.", "The end of the beginning: structural studies of ribosomal proteins." ]

[ 2001, 2001, 2000 ]

3

[ "IPR022801" ]

[ "IPR022802" ]

1

0

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 917, 2, 5596, 42 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 6, 1, 1, 3, 7, 6, 1, 10, 6, 2, 2, 16 ]

12

true

Family

Small ribosomal subunit protein uS4, eukaryota/archaea

Ribosomal_uS4_euk_arc

7

IPR005712

5,712

Small ribosomal subunit protein uS5, bacteria

Ribosomal_uS5_bact

Family

24,139

false

This family includes chloroplast ribosomal protein uS5 as well as bacterial ribosomal protein uS5. A candidate mitochondrial form (Saccharomyces cerevisiae YBR251W and its homologues) differs substantially and is not included in this model. Ribosomes are the particles that catalyse mRNA-directed protein synthesis in al...

[ "GO:0003735", "GO:0006412", "GO:0015935" ]

[ "structural constituent of ribosome", "translation", "small ribosomal subunit" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "HAMAP", "NCBIFAM" ]

[ "MF_01307_B", "TIGR01021" ]

[ "Ribosomal_uS5_B", "rpsE_bact" ]

[ 23750, 24127 ]

2

[]

0

[ "1dv4", "1eg0", "1fjg", "1fka", "1hnw", "1hnx", "1hnz", "1hr0", "1i94", "1i95", "1i96", "1i97", "1ibk", "1ibl", "1ibm", "1j5e", "1jgo", "1jgp", "1jgq", "1ml5", "1n32", "1n33", "1n34", "1n36", "1pkp", "1qd7", "1vvj", "1vy4", "1vy5", "1vy6", "1vy7", "1xmo"...

1,182

[ "PUB00007068", "PUB00007069", "PUB00007070" ]

[ "11297922", "11290319", "11114498" ]

[ "Atomic structures at last: the ribosome in 2000.", "The ribosome in focus.", "The end of the beginning: structural studies of ribosomal proteins." ]

[ 2001, 2001, 2000 ]

3

[ "IPR000851" ]

[]

1

0

1

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 22690, 1061, 388 ]

3

[ "Arabidopsis thaliana", "Escherichia coli (strain K12)", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 3, 1, 3, 4 ]

4

true

Family

Small ribosomal subunit protein uS5, bacteria

Ribosomal_uS5_bact

9

IPR005713

5,713

Small ribosomal subunit protein uS19, eukaryota/archaea

Ribosomal_uS19_euk_arc

Family

6,524

false

This family represents eukaryotic ribosomal protein uS19 and its archaeal equivalent. It excludes bacterial and organellar ribosomal protein S19. Ribosomes are the particles that catalyse mRNA-directed protein synthesis in all organisms. The codons of the mRNA are exposed on the ribosome to allow tRNA binding. This lea...

[ "GO:0003735", "GO:0006412", "GO:0015935" ]

[ "structural constituent of ribosome", "translation", "small ribosomal subunit" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "NCBIFAM" ]

[ "TIGR01025" ]

[ "uS19_arch" ]

[ 6524 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-156827", "R-BTA-1799339", "R-BTA-6791226", "R-BTA-72649", "R-BTA-72689", "R-BTA-72695", "R-BTA-72702", "R-BTA-72706", "R-BTA-975956", "R-BTA-975957", "R-CEL-156827", "R-CEL-1799339", "R-CEL-72649", "R-CEL-72689", "R-CEL-72695", "R-CEL-72702", "R-CEL-72706", "R-CEL-975956", ...

[ "REACTOME:R-BTA-156827", "REACTOME:R-BTA-1799339", "REACTOME:R-BTA-6791226", "REACTOME:R-BTA-72649", "REACTOME:R-BTA-72689", "REACTOME:R-BTA-72695", "REACTOME:R-BTA-72702", "REACTOME:R-BTA-72706", "REACTOME:R-BTA-975956", "REACTOME:R-BTA-975957", "REACTOME:R-CEL-156827", "REACTOME:R-CEL-179933...

100

[ "3j6x", "3j6y", "3j77", "3j78", "3j7a", "3j7p", "3j7r", "3j80", "3j81", "3jag", "3jah", "3jai", "3jaj", "3jam", "3jan", "3jap", "3jbn", "3jbo", "3jbp", "4d5l", "4d61", "4kzx", "4kzy", "4kzz", "4u3m", "4u3n", "4u3u", "4u4n", "4u4o", "4u4q", "4u4r", "4u4u"...

567

[ "PUB00007068", "PUB00007069", "PUB00007070" ]

[ "11297922", "11290319", "11114498" ]

[ "Atomic structures at last: the ribosome in 2000.", "The ribosome in focus.", "The end of the beginning: structural studies of ribosomal proteins." ]

[ 2001, 2001, 2000 ]

3

[ "IPR002222" ]

[]

1

0

1

[ "Archaea", "Eukaryota", "unclassified sequences" ]

[ 890, 5603, 31 ]

3

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 23, 1, 1, 2, 7, 4, 1, 6, 4, 1, 2, 21 ]

12

true

Family

Small ribosomal subunit protein uS19, eukaryota/archaea

Ribosomal_uS19_euk_arc

4

IPR005714

5,714

ATPase, type III secretion system, FliI/YscN

ATPase_T3SS_FliI/YscN

Family

16,937

false

Proteins in this entry show extensive homology to the ATP synthase F1 beta subunit, and are involved in type III protein secretion. They fall into the two separate functional groups outlined below. The first group, exemplified by the Salmonella typhimurium FliI protein ( ), is needed for flagellar assembly. Most struct...

[ "GO:0016887", "GO:0009058", "GO:0030254", "GO:0005737", "GO:0030257" ]

[ "ATP hydrolysis activity", "biosynthetic process", "protein secretion by the type III secretion system", "cytoplasm", "type III protein secretion system complex" ]

[ "molecular_function", "biological_process", "biological_process", "cellular_component", "cellular_component" ]

5

[ "NCBIFAM" ]

[ "TIGR01026" ]

[ "fliI_yscN" ]

[ 16937 ]

1

[]

0

[ "2dpy", "2obl", "2obm", "4nph", "5b0o", "5swj", "5swl", "5syp", "5syr", "5ybh", "5ybi", "5zt1", "6n6l", "6n6m", "6n6z", "6n70", "6n71", "6n72", "6n73", "6n74", "6n75", "6n76", "6njo", "6njp", "6rad", "6rae", "6sdx" ]

27

[ "PUB00034693", "PUB00034694", "PUB00034695", "PUB00097887" ]

[ "15170399", "17012787", "16672607", "21611119" ]

[ "Self-assembly and type III protein export of the bacterial flagellum.", "Crystallization and preliminary X-ray analysis of Salmonella FliI, the ATPase component of the type III flagellar protein-export apparatus.", "Characterization of the Yersinia enterocolitica type III secretion ATPase YscN and its regulato...

[ 2004, 2006, 2006, 2011 ]

4

[]

[ "IPR013380", "IPR020005", "IPR022425", "IPR022426" ]

0

4

0

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 16777, 26, 134 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

ATPase, type III secretion system, FliI/YscN

ATPase_T3SS_FliI/YscN

3

IPR005715

5,715

Glutamate 5-kinase/delta-1-pyrroline-5-carboxylate synthase

Glu_5kinase/COase_Synthase

Family

28,317

false

L-glutamate 5-phosphotransferase, (gamma-glutamyl kinase, proB, ), catalyzes the first step in proline biosynthesis ATP + L-glutamate = ADP + L-glutamate 5-phosphate. the product of which rapidly cyclises to 5-oxoproline and phosphate. This entry also includes delta-1-pyrroline-5-carboxylate synthase, an enzyme that in...

[ "GO:0055129", "GO:0005737" ]

[ "L-proline biosynthetic process", "cytoplasm" ]

[ "biological_process", "cellular_component" ]

2

[ "HAMAP", "NCBIFAM" ]

[ "MF_00456", "TIGR01027" ]

[ "ProB", "proB" ]

[ 27403, 28019 ]

2

[ "EC", "GP", "GP", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "2.7.2.11", "GenProp0111", "GenProp1472", "PWY-6922", "R-CEL-8964539", "R-CEL-9837999", "R-HSA-8964539", "R-HSA-9837999", "R-MMU-8964539", "R-MMU-9837999" ]

[ "EC:2.7.2.11", "GP:GenProp0111", "GP:GenProp1472", "METACYC:PWY-6922", "REACTOME:R-CEL-8964539", "REACTOME:R-CEL-9837999", "REACTOME:R-HSA-8964539", "REACTOME:R-HSA-9837999", "REACTOME:R-MMU-8964539", "REACTOME:R-MMU-9837999" ]

10

[ "2ako", "2j5t", "2j5v", "2w21", "4q1t", "7f5t", "7f5u", "7f5v", "7f5x", "7wx3", "7wx4", "7wxf", "7wxg", "7wxh", "7wxi", "8j0e", "8j0f", "8j0g", "8j27", "8j28", "8y2h", "8zpj", "8zpr", "8zri" ]

24

[]

0

[ "IPR001057" ]

[ "IPR005766", "IPR011529" ]

1

2

0

[ "Archaea", "Bacteria", "Eukaryota", "Hyperionvirus sp.", "unclassified sequences" ]

[ 274, 21960, 5628, 1, 454 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus",...

[ 8, 1, 4, 1, 1, 1, 4, 1, 4, 2, 2, 1, 19 ]

13

true

Family

Glutamate 5-kinase/delta-1-pyrroline-5-carboxylate synthase

Glu_5kinase/COase_Synthase

6

IPR005716

5,716

Ribosomal protein uS7, eukaryotic/archaeal

Ribosomal_uS7_euk/arc

Family

13,672

false

This family describes eukaryotic and archaeal uS7 ribosomal proteins. The eukaryotic protein was previously known as S5. Ribosomal protein (RP)S5 has variable N-terminal regions that affect the efficiency of initiation translation process by impacting small ribosomal subunit to function [ ]. RPS7 is located at the head...

[ "GO:0003735", "GO:0006412", "GO:0015935" ]

[ "structural constituent of ribosome", "translation", "small ribosomal subunit" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "NCBIFAM", "CDD" ]

[ "TIGR01028", "cd14867" ]

[ "uS7_euk_arch", "uS7_Eukaryote" ]

[ 13585, 13535 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-156827", "R-BTA-1799339", "R-BTA-6791226", "R-BTA-72649", "R-BTA-72689", "R-BTA-72695", "R-BTA-72702", "R-BTA-72706", "R-BTA-975956", "R-BTA-975957", "R-CEL-156827", "R-CEL-1799339", "R-CEL-72649", "R-CEL-72689", "R-CEL-72695", "R-CEL-72702", "R-CEL-72706", "R-CEL-975956", ...

[ "REACTOME:R-BTA-156827", "REACTOME:R-BTA-1799339", "REACTOME:R-BTA-6791226", "REACTOME:R-BTA-72649", "REACTOME:R-BTA-72689", "REACTOME:R-BTA-72695", "REACTOME:R-BTA-72702", "REACTOME:R-BTA-72706", "REACTOME:R-BTA-975956", "REACTOME:R-BTA-975957", "REACTOME:R-CEL-156827", "REACTOME:R-CEL-179933...

92

[ "1iqv", "2noq", "3j0l", "3j0o", "3j6x", "3j6y", "3j77", "3j78", "3j7a", "3j7p", "3j7r", "3j80", "3j81", "3jag", "3jah", "3jai", "3jaj", "3jam", "3jan", "3jap", "3jbn", "3jbo", "3jbp", "4bts", "4d5l", "4d61", "4kzx", "4kzy", "4kzz", "4u3m", "4u3n", "4u3u"...

630

[ "PUB00021787", "PUB00026111", "PUB00080277", "PUB00080278" ]

[ "9331423", "11686933", "9582096", "19969550" ]

[ "Ribosomal protein S7: a new RNA-binding motif with structural similarities to a DNA architectural factor.", "The structure of the archaebacterial ribosomal protein S7 and its possible interaction with 16S rRNA.", "Matching the crystallographic structure of ribosomal protein S7 to a three-dimensional model of t...

[ 1997, 2001, 1998, 2010 ]

4

[ "IPR000235" ]

[ "IPR026018" ]

1

0

[ "Archaea", "Candidatus Rhodobacter oscarellae", "Eukaryota", "unclassified sequences" ]

[ 892, 1, 12751, 28 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 5, 1, 2, 3, 4, 3, 1, 5, 4, 1, 2, 8 ]

12

true

Family

Ribosomal protein uS7, eukaryotic/archaeal

Ribosomal_uS7_euk/arc

2

IPR005717

5,717

Small ribosomal subunit protein uS7, bacteria/organella

Ribosomal_uS7_bact_org

Family

38,341

false

This entry represents the bacterial and organellar branch of the ribosomal protein uS7 family. Ribosomes are the particles that catalyse mRNA-directed protein synthesis in all organisms. The codons of the mRNA are exposed on the ribosome to allow tRNA binding. This leads to the incorporation of amino acids into the gro...

[ "GO:0003735", "GO:0006412", "GO:0015935" ]

[ "structural constituent of ribosome", "translation", "small ribosomal subunit" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "HAMAP", "NCBIFAM" ]

[ "MF_00480_B", "TIGR01029" ]

[ "Ribosomal_uS7_B", "rpsG_bact" ]

[ 37083, 38300 ]

2

[]

0

[ "1dv4", "1eg0", "1fjg", "1fka", "1hnw", "1hnx", "1hnz", "1hr0", "1hus", "1i94", "1i95", "1i96", "1i97", "1ibk", "1ibl", "1ibm", "1j5e", "1jgo", "1jgp", "1jgq", "1ml5", "1n32", "1n33", "1n34", "1n36", "1qd7", "1rss", "1vvj", "1vy4", "1vy5", "1vy6", "1vy7"...

1,172

[ "PUB00007068", "PUB00007069", "PUB00007070" ]

[ "11297922", "11290319", "11114498" ]

[ "Atomic structures at last: the ribosome in 2000.", "The ribosome in focus.", "The end of the beginning: structural studies of ribosomal proteins." ]

[ 2001, 2001, 2000 ]

3

[ "IPR000235" ]

[ "IPR034643" ]

1

0

[ "Bacteria", "Candidatus Methanofastidiosum methylothiophilum", "Eukaryota", "unclassified sequences" ]

[ 23318, 1, 14630, 392 ]

4

[ "Arabidopsis thaliana", "Escherichia coli (strain K12)", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 7, 1, 10, 6 ]

4

true

Family

Small ribosomal subunit protein uS7, bacteria/organella

Ribosomal_uS7_bact_org

1

IPR005719

5,719

Dihydroorotate dehydrogenase, class 2

Dihydroorotate_DH_2

Family

22,763

false

This entry represents the enzyme protein dihydroorotate dehydrogenase (also called quinone) exclusively for class 2. It includes members from bacteria, yeast, plants etc. The subfamilies 1 and 2 share extensive homology, particularly toward the C terminus. This subfamily has a longer N-terminal region. Dihydroorotate d...

[ "GO:0004152", "GO:0006207", "GO:0016020" ]

[ "dihydroorotate dehydrogenase activity", "'de novo' pyrimidine nucleobase biosynthetic process", "membrane" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "HAMAP", "NCBIFAM", "CDD" ]

[ "MF_00225", "TIGR01036", "cd04738" ]

[ "DHO_dh_type2", "pyrD_sub2", "DHOD_2_like" ]

[ 16179, 22200, 22748 ]

3

[ "EC", "GP", "GP", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "1.3.5.2", "GenProp0187", "GenProp1427", "PWY-5686", "R-DME-500753", "R-HSA-500753", "R-MMU-500753", "R-PFA-500753", "R-RNO-500753", "R-SPO-500753" ]

[ "EC:1.3.5.2", "GP:GenProp0187", "GP:GenProp1427", "METACYC:PWY-5686", "REACTOME:R-DME-500753", "REACTOME:R-HSA-500753", "REACTOME:R-MMU-500753", "REACTOME:R-PFA-500753", "REACTOME:R-RNO-500753", "REACTOME:R-SPO-500753" ]

10

[ "1d3g", "1d3h", "1f76", "1tv5", "1uum", "1uuo", "2b0m", "2bxv", "2fpt", "2fpv", "2fpy", "2fqi", "2prh", "2prl", "2prm", "2wv8", "3f1q", "3fj6", "3fjl", "3g0u", "3g0x", "3i65", "3i68", "3i6r", "3kvj", "3kvk", "3kvl", "3kvm", "3o8a", "3sfk", "3u2o", "3w7r"...

153

[ "PUB00005052", "PUB00024104", "PUB00024613", "PUB00033267", "PUB00033268" ]

[ "9655329", "10673429", "11188687", "9405053", "12220493" ]

[ "The crystal structure of Lactococcus lactis dihydroorotate dehydrogenase A complexed with the enzyme reaction product throws light on its enzymatic function.", "Structures of human dihydroorotate dehydrogenase in complex with antiproliferative agents.", "Structure of dihydroorotate dehydrogenase B: electron tr...

[ 1998, 2000, 2000, 1997, 2002 ]

5

[ "IPR012135" ]

[]

1

0

1

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 364, 17719, 4500, 180 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus",...

[ 5, 1, 2, 1, 1, 2, 3, 1, 1, 8, 1, 3 ]

12

true

Family

Dihydroorotate dehydrogenase, class 2

Dihydroorotate_DH_2

7

IPR005720

5,720

Dihydroorotate dehydrogenase, catalytic

Dihydroorotate_DH_cat

Domain

45,636

false

This entry represents a domain found in dihydroorotate and dihydropyrimidine dehydrogenases. Dihydroorotate dehydrogenases included in this entry catalyse the conversion of dihydroorotate to orotate using quinone, fumarate and NAD+ as electron acceptor [ ]. Dihydropyrimidine dehydrogenases catalyse the conversion of 5,...

[ "GO:0016627", "GO:0005737" ]

[ "oxidoreductase activity, acting on the CH-CH group of donors", "cytoplasm" ]

[ "molecular_function", "cellular_component" ]

2

[ "PFAM" ]

[ "PF01180" ]

[ "DHO_dh" ]

[ 45636 ]

1

[ "EC", "GP", "GP", "GP", "GP", "GP", "GP", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "1.3.5.2", "GenProp0187", "GenProp1273", "GenProp1371", "GenProp1380", "GenProp1418", "GenProp1614", "PWY-5686", "R-CEL-73621", "R-DDI-73621", "R-DME-500753", "R-DRE-73621", "R-HSA-500753", "R-HSA-73621", "R-MMU-500753", "R-MMU-73621", "R-PFA-500753", "R-RNO-500753", "R-RNO-73621...

[ "EC:1.3.5.2", "GP:GenProp0187", "GP:GenProp1273", "GP:GenProp1371", "GP:GenProp1380", "GP:GenProp1418", "GP:GenProp1614", "METACYC:PWY-5686", "REACTOME:R-CEL-73621", "REACTOME:R-DDI-73621", "REACTOME:R-DME-500753", "REACTOME:R-DRE-73621", "REACTOME:R-HSA-500753", "REACTOME:R-HSA-73621", ...

20

[ "1d3g", "1d3h", "1dor", "1ep1", "1ep2", "1ep3", "1f76", "1gt8", "1gte", "1gth", "1h7w", "1h7x", "1jqv", "1jqx", "1jrb", "1jrc", "1jub", "1jue", "1ovd", "1tv5", "1uum", "1uuo", "2b0m", "2b4g", "2bsl", "2bx7", "2bxv", "2djl", "2djx", "2dor", "2e68", "2e6a"...

265

[ "PUB00004801", "PUB00056837", "PUB00153011" ]

[ "1409592", "8021180", "1512248" ]

[ "Divergent evolution of pyrimidine biosynthesis between anaerobic and aerobic yeasts.", "Two different dihydroorotate dehydrogenases in Lactococcus lactis.", "Purification and characterization of dihydropyrimidine dehydrogenase from human liver." ]

[ 1992, 1994, 1992 ]

3

[]

[ "IPR049622" ]

0

1

0

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 1006, 34170, 9539, 9, 912 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus",...

[ 9, 2, 6, 5, 2, 5, 11, 2, 3, 12, 1, 1, 8 ]

13

true

Domain

Dihydroorotate dehydrogenase, catalytic

Dihydroorotate_DH_cat

2

IPR005721

5,721

Large ribosomal subunit protein uL22, eukaryota/archaea

Ribosomal_uL22_euk_arc

Family

8,055

false

This family describes the ribosomal protein of the eukaryotic and archaeal uL22 , previously known as L17 and L22. Ribosomes are the particles that catalyse mRNA-directed protein synthesis in all organisms. The codons of the mRNA are exposed on the ribosome to allow tRNA binding. This leads to the incorporation of amin...

[ "GO:0003735", "GO:0006412", "GO:0015934" ]

[ "structural constituent of ribosome", "translation", "large ribosomal subunit" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PANTHER", "NCBIFAM" ]

[ "PTHR11593", "TIGR01038" ]

[ "", "uL22_arch_euk" ]

[ 7954, 7632 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-CEL-156827", "R-CEL-1799339", "R-CEL-72689", "R-CEL-72706", "R-CEL-975956", "R-CEL-975957", "R-DDI-156827", "R-DDI-1799339", "R-DDI-72689", "R-DDI-72706", "R-DDI-975956", "R-DDI-975957", "R-DME-156827", "R-DME-1799339", "R-DME-72689", "R-DME-72706", "R-DME-975956", "R-DME-975957...

[ "REACTOME:R-CEL-156827", "REACTOME:R-CEL-1799339", "REACTOME:R-CEL-72689", "REACTOME:R-CEL-72706", "REACTOME:R-CEL-975956", "REACTOME:R-CEL-975957", "REACTOME:R-DDI-156827", "REACTOME:R-DDI-1799339", "REACTOME:R-DDI-72689", "REACTOME:R-DDI-72706", "REACTOME:R-DDI-975956", "REACTOME:R-DDI-97595...

57

[ "1ffk", "1jj2", "1k73", "1k8a", "1k9m", "1kc8", "1kd1", "1kqs", "1m1k", "1m90", "1n8r", "1nji", "1q7y", "1q81", "1q82", "1q86", "1qvf", "1qvg", "1s72", "1vq4", "1vq5", "1vq6", "1vq7", "1vq8", "1vq9", "1vqk", "1vql", "1vqm", "1vqn", "1vqo", "1vqp", "1w2b"...

684

[ "PUB00007068", "PUB00007069", "PUB00007070" ]

[ "11297922", "11290319", "11114498" ]

[ "Atomic structures at last: the ribosome in 2000.", "The ribosome in focus.", "The end of the beginning: structural studies of ribosomal proteins." ]

[ 2001, 2001, 2000 ]

3

[ "IPR001063" ]

[ "IPR057265" ]

1

0

[ "Archaea", "Eukaryota", "Pantoea vagans", "unclassified sequences" ]

[ 921, 7095, 1, 38 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 7, 1, 1, 2, 15, 6, 1, 4, 13, 2, 2, 37 ]

12

true

Family

Large ribosomal subunit protein uL22, eukaryota/archaea

Ribosomal_uL22_euk_arc

4

IPR005722

5,722

ATP synthase, F1 complex, beta subunit

ATP_synth_F1_bsu

Family

55,679

false

This entry represents the beta subunit found in the F1 complex of F-ATPases. F-ATPases (also known as ATP synthases, F1F0-ATPase, or H(+)-transporting two-sector ATPase) ( ) are composed of two linked complexes: the F1 ATPase complex is the catalytic core and is composed of 5 subunits (alpha, beta, gamma, delta, epsilo...

[ "GO:0046933", "GO:0015986", "GO:0045259" ]

[ "proton-transporting ATP synthase activity, rotational mechanism", "proton motive force-driven ATP synthesis", "proton-transporting ATP synthase complex" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "HAMAP", "NCBIFAM" ]

[ "MF_01347", "TIGR01039" ]

[ "ATP_synth_beta_bact", "atpD" ]

[ 52029, 55577 ]

2

[ "EC", "GP", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTO...

[ "7.1.2.2", "GenProp0128", "PWY-7980", "R-CEL-1268020", "R-CEL-163210", "R-CEL-8949613", "R-CEL-9837999", "R-CFA-1268020", "R-CFA-163210", "R-CFA-8949613", "R-CFA-9837999", "R-DDI-1268020", "R-DDI-9837999", "R-DME-1268020", "R-DME-163210", "R-DME-8949613", "R-DME-9837999", "R-HSA-12...

[ "EC:7.1.2.2", "GP:GenProp0128", "METACYC:PWY-7980", "REACTOME:R-CEL-1268020", "REACTOME:R-CEL-163210", "REACTOME:R-CEL-8949613", "REACTOME:R-CEL-9837999", "REACTOME:R-CFA-1268020", "REACTOME:R-CFA-163210", "REACTOME:R-CFA-8949613", "REACTOME:R-CFA-9837999", "REACTOME:R-DDI-1268020", "REACTOM...

32

[ "1bmf", "1cow", "1e1q", "1e1r", "1e79", "1efr", "1fx0", "1h8e", "1h8h", "1kmh", "1mab", "1nbm", "1ohh", "1qo1", "1sky", "1w0j", "1w0k", "2ck3", "2f43", "2hld", "2jdi", "2jiz", "2jj1", "2jj2", "2qe7", "2v7q", "2w6e", "2w6f", "2w6g", "2w6h", "2w6i", "2w6j"...

337

[ "PUB00007884", "PUB00009752", "PUB00020611" ]

[ "11533724", "11309608", "12745923" ]

[ "ATP synthase--a marvellous rotary engine of the cell.", "Resolution of distinct rotational substeps by submillisecond kinetic analysis of F1-ATPase.", "Understanding ATP synthesis: structure and mechanism of the F1-ATPase (Review)." ]

[ 2001, 2001, 2003 ]

3

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 27, 25249, 29999, 404 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus",...

[ 12, 1, 1, 7, 1, 4, 1, 1, 19, 5, 1, 1, 24 ]

13

true

Family

ATP synthase, F1 complex, beta subunit

ATP_synth_F1_bsu

3

IPR005723

5,723

ATPase, V1 complex, subunit B

ATPase_V1-cplx_bsu

Family

5,705

false

This entry represents subunit B from the V1 complex of V-ATPases. There are three copies each of subunits A ( ) and B, both of which participate in nucleotide binding. However, only subunit A is catalytic for ATP hydrolysis, subunit B being noncatalytic [ , ]. Transmembrane ATPases are membrane-bound enzyme complexes/i...

[ "GO:0046961", "GO:1902600", "GO:0033180" ]

[ "proton-transporting ATPase activity, rotational mechanism", "proton transmembrane transport", "proton-transporting V-type ATPase, V1 domain" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "NCBIFAM" ]

[ "TIGR01040" ]

[ "V-ATPase_V1_B" ]

[ 5705 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-1222556", "R-BTA-77387", "R-BTA-917977", "R-BTA-9639288", "R-BTA-983712", "R-CEL-1222556", "R-CEL-77387", "R-CEL-917977", "R-CEL-9639288", "R-CEL-983712", "R-DDI-1222556", "R-DDI-77387", "R-DDI-917977", "R-DDI-9639288", "R-DME-1222556", "R-DME-77387", "R-DME-917977", "R-DME-...

[ "REACTOME:R-BTA-1222556", "REACTOME:R-BTA-77387", "REACTOME:R-BTA-917977", "REACTOME:R-BTA-9639288", "REACTOME:R-BTA-983712", "REACTOME:R-CEL-1222556", "REACTOME:R-CEL-77387", "REACTOME:R-CEL-917977", "REACTOME:R-CEL-9639288", "REACTOME:R-CEL-983712", "REACTOME:R-DDI-1222556", "REACTOME:R-DDI-...

43

[ "3j9t", "3j9u", "3j9v", "5bw9", "5d80", "5vox", "5voy", "5voz", "6o7v", "6o7w", "6o7x", "6vq6", "6vq7", "6vq8", "6vq9", "6vqa", "6vqb", "6wlz", "6wm2", "6wm3", "6wm4", "6xbw", "6xby", "7fda", "7fdb", "7fdc", "7fde", "7khr", "7tmm", "7tmo", "7tmp", "7tmq"...

66

[ "PUB00007885", "PUB00020603", "PUB00020604", "PUB00020608", "PUB00020609", "PUB00068786", "PUB00068787", "PUB00068788", "PUB00068789" ]

[ "11836511", "15473999", "15078220", "15907459", "15629643", "20450191", "18937357", "1385979", "9741106" ]

[ "The vacuolar (H+)-ATPases--nature's most versatile proton pumps.", "The evolution of A-, F-, and V-type ATP synthases and ATPases: reversals in function and changes in the H+/ATP coupling ratio.", "Mechanisms of ATPases--a multi-disciplinary approach.", "A new view of an old pore.", "A structural model of ...

[ 2002, 2004, 2004, 2005, 2005, 2010, 2008, 1992, 1998 ]

9

[ "IPR022879" ]

[]

1

0

1

[ "Eukaryota" ]

[ 5705 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 11, 2, 4, 2, 9, 4, 1, 5, 5, 1, 1, 9 ]

12

true

Family

ATPase, V1 complex, subunit B

ATPase_V1-cplx_bsu

2

IPR005724

5,724

ATPase, A1 complex, beta subunit

ATPase_A1-cplx_bsu

Family

466

false

This entry represents the beta subunit from the A1 complex of A-ATPases. The A1 complex contains three copies each of subunits alpha (or A) ( ), and beta (or B), both of which form the headpiece that participates in nucleotide binding. However, only the alpha subunit is catalytic, the beta subunit being regulatory in f...

[ "GO:0046933", "GO:0015986", "GO:0033178" ]

[ "proton-transporting ATP synthase activity, rotational mechanism", "proton motive force-driven ATP synthesis", "proton-transporting two-sector ATPase complex, catalytic domain" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "NCBIFAM" ]

[ "TIGR01041" ]

[ "ATP_syn_B_arch" ]

[ 466 ]

1

[ "GP" ]

[ "GenProp0629" ]

[ "GP:GenProp0629" ]

1

[ "2c61", "2rkw", "3b2q", "3dsr", "3eiu", "3ssa", "3tgw", "3tiv" ]

8

[ "PUB00002959", "PUB00020603", "PUB00020604", "PUB00020617", "PUB00020618", "PUB00020635", "PUB00068786", "PUB00068787", "PUB00068788", "PUB00068789" ]

[ "8702544", "15473999", "15078220", "10340845", "15168615", "14988401", "20450191", "18937357", "1385979", "9741106" ]

[ "Subunit structure and organization of the genes of the A1A0 ATPase from the Archaeon Methanosarcina mazei Go1.", "The evolution of A-, F-, and V-type ATP synthases and ATPases: reversals in function and changes in the H+/ATP coupling ratio.", "Mechanisms of ATPases--a multi-disciplinary approach.", "Structur...

[ 1996, 2004, 2004, 1999, 2004, 2004, 2010, 2008, 1992, 1998 ]

10

[ "IPR022879" ]

[]

1

0

1

[ "Archaea", "unclassified sequences" ]

[ 464, 2 ]

2

[]

0

true

Family

ATPase, A1 complex, beta subunit

ATPase_A1-cplx_bsu

7

IPR005725

5,725

ATPase, V1 complex, subunit A

ATPase_V1-cplx_asu

Family

4,659

false

This entry represents subunit A from the V1 complex of V-ATPases. There are three copies each of subunits A and B ( ), both of which participate in nucleotide binding. However, only subunit A is catalytic, functioning in ATP hydrolysis to drive the rotation of the D and F subunits of V1, as well as the V0 complex c-rin...

[ "GO:0016887", "GO:0046961", "GO:1902600", "GO:0033180" ]

[ "ATP hydrolysis activity", "proton-transporting ATPase activity, rotational mechanism", "proton transmembrane transport", "proton-transporting V-type ATPase, V1 domain" ]

[ "molecular_function", "molecular_function", "biological_process", "cellular_component" ]

4

[ "NCBIFAM" ]

[ "TIGR01042" ]

[ "V-ATPase_V1_A" ]

[ 4659 ]

1

[ "EC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "...

[ "7.1.2.2", "PWY-7980", "R-BTA-1222556", "R-BTA-77387", "R-BTA-917977", "R-BTA-9639288", "R-BTA-983712", "R-CEL-1222556", "R-CEL-77387", "R-CEL-917977", "R-CEL-9639288", "R-CEL-983712", "R-DDI-1222556", "R-DDI-77387", "R-DDI-917977", "R-DDI-9639288", "R-DME-1222556", "R-DME-77387", ...

[ "EC:7.1.2.2", "METACYC:PWY-7980", "REACTOME:R-BTA-1222556", "REACTOME:R-BTA-77387", "REACTOME:R-BTA-917977", "REACTOME:R-BTA-9639288", "REACTOME:R-BTA-983712", "REACTOME:R-CEL-1222556", "REACTOME:R-CEL-77387", "REACTOME:R-CEL-917977", "REACTOME:R-CEL-9639288", "REACTOME:R-CEL-983712", "REACT...

39

[ "3j9t", "3j9u", "3j9v", "5bw9", "5d80", "5vox", "5voy", "5voz", "6o7v", "6o7w", "6o7x", "6vq6", "6vq7", "6vq8", "6vq9", "6vqa", "6vqb", "6wlz", "6wm2", "6wm3", "6wm4", "6xbw", "6xby", "7fda", "7fdb", "7fdc", "7fde", "7khr", "7tmm", "7tmo", "7tmp", "7tmq"...

65

[ "PUB00007885", "PUB00007886", "PUB00020603", "PUB00020604", "PUB00020608", "PUB00020609", "PUB00068786", "PUB00068787", "PUB00068788", "PUB00068789", "PUB00160299" ]

[ "11836511", "11533110", "15473999", "15078220", "15907459", "15629643", "20450191", "18937357", "1385979", "9741106", "9874757" ]

[ "The vacuolar (H+)-ATPases--nature's most versatile proton pumps.", "Structure-function relationships of A-, F- and V-ATPases.", "The evolution of A-, F-, and V-type ATP synthases and ATPases: reversals in function and changes in the H+/ATP coupling ratio.", "Mechanisms of ATPases--a multi-disciplinary approa...

[ 2002, 2001, 2004, 2004, 2005, 2005, 2010, 2008, 1992, 1998, 1992 ]

11

[ "IPR022878" ]

[]

1

0

1

[ "Archaea", "Eukaryota" ]

[ 4, 4655 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Schizosaccharomyces pombe (stra...

[ 4, 1, 2, 7, 2, 1, 1, 4, 4, 1, 12 ]

11

true

Family

ATPase, V1 complex, subunit A

ATPase_V1-cplx_asu

1

IPR005726

5,726

ATP synthase alpha chain, archaea

ATP_synth_asu_arc

Family

639

false

This entry represents the alpha subunit from the A1 complex of A-ATPases. The A1 complex contains three copies each of subunits alpha (or A) and beta (or B) ( ), both of which form the headpiece that participates in nucleotide binding. However, only the alpha subunit is catalytic, the beta subunit being regulatory in f...

[ "GO:0046961", "GO:0015986", "GO:0033178" ]

[ "proton-transporting ATPase activity, rotational mechanism", "proton motive force-driven ATP synthesis", "proton-transporting two-sector ATPase complex, catalytic domain" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "NCBIFAM" ]

[ "TIGR01043" ]

[ "ATP_syn_A_arch" ]

[ 639 ]

1

[ "EC", "GP", "METACYC" ]

[ "7.1.2.2", "GenProp0629", "PWY-7980" ]

[ "EC:7.1.2.2", "GP:GenProp0629", "METACYC:PWY-7980" ]

3

[ "1vdz", "3i4l", "3i72", "3i73", "3ikj", "3m4y", "3mfy", "3nd8", "3nd9", "3p20", "3qg1", "3qia", "3qjy", "3sdz", "3se0", "5x09" ]

16

[ "PUB00002959", "PUB00020603", "PUB00020604", "PUB00020617", "PUB00020618", "PUB00020635", "PUB00068786", "PUB00068787", "PUB00068788", "PUB00068789" ]

[ "8702544", "15473999", "15078220", "10340845", "15168615", "14988401", "20450191", "18937357", "1385979", "9741106" ]

[ "Subunit structure and organization of the genes of the A1A0 ATPase from the Archaeon Methanosarcina mazei Go1.", "The evolution of A-, F-, and V-type ATP synthases and ATPases: reversals in function and changes in the H+/ATP coupling ratio.", "Mechanisms of ATPases--a multi-disciplinary approach.", "Structur...

[ 1996, 2004, 2004, 1999, 2004, 2004, 2010, 2008, 1992, 1998 ]

10

[ "IPR022878" ]

[]

1

0

1

[ "Archaea", "Bacteria", "ecological metagenomes" ]

[ 613, 24, 2 ]

3

[]

0

true

Family

ATP synthase alpha chain, archaea

ATP_synth_asu_arc

3

IPR005727

5,727

Large ribosomal subunit protein uL22, bacterial/chloroplast-type

Ribosomal_uL22_bac/chlpt-type

Family

37,192

false

This model describes bacterial and chloroplast ribosomal protein uL22. Ribosomes are the particles that catalyse mRNA-directed protein synthesis in all organisms. The codons of the mRNA are exposed on the ribosome to allow tRNA binding. This leads to the incorporation of amino acids into the growing polypeptide chain i...

[ "GO:0003735", "GO:0006412", "GO:0015934" ]

[ "structural constituent of ribosome", "translation", "large ribosomal subunit" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "HAMAP", "NCBIFAM" ]

[ "MF_01331_B", "TIGR01044" ]

[ "Ribosomal_uL22_B", "rplV_bact" ]

[ 36806, 37050 ]

2

[]

0

[ "1bxe", "1i4j", "1j5a", "1jzx", "1jzy", "1jzz", "1k01", "1ml5", "1nkw", "1nwx", "1nwy", "1ond", "1sm1", "1vvj", "1vy4", "1vy5", "1vy6", "1vy7", "1xbp", "2j28", "2rdo", "2zjp", "2zjq", "2zjr", "3bbx", "3cf5", "3dll", "3j3v", "3j3w", "3j5l", "3j7z", "3j8g"...

1,165

[ "PUB00007068", "PUB00007069", "PUB00007070" ]

[ "11297922", "11290319", "11114498" ]

[ "Atomic structures at last: the ribosome in 2000.", "The ribosome in focus.", "The end of the beginning: structural studies of ribosomal proteins." ]

[ 2001, 2001, 2000 ]

3

[ "IPR047867" ]

[]

1

0

1

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 23581, 13206, 405 ]

3

[ "Arabidopsis thaliana", "Escherichia coli (strain K12)", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 11, 1, 6, 6 ]

4

true

Family

Large ribosomal subunit protein uL22, bacterial/chloroplast-type

Ribosomal_uL22_bac/chlpt-type

5

IPR005728

5,728

Rickettsial palindromic element 1

RPE1

Domain

816

false

This domain describes protein translations of the Rickettsia conorii elements (RPE). In Rickettsia conorii, 19 copies are found within protein coding regions, where they encode an insert relative to homologues from other species but do not disrupt the reading frame. Insertion is always in the same reading frame. This m...

[]

0

[ "NCBIFAM" ]

[ "TIGR01045" ]

[ "RPE1" ]

[ 816 ]

1

[ "GP" ]

[ "GenProp0476" ]

[ "GP:GenProp0476" ]

1

[]

0

[]

0

[]

0

null

[ "Protostomia", "Pseudomonadota" ]

[ 22, 794 ]

2

[]

0

true

Domain

Rickettsial palindromic element 1

RPE1

7

IPR005729

5,729

Small ribosomal subunit protein uS10, eukaryotic/archaeal

Ribosomal_uS10_euk/arc

Family

6,074

false

This model describes the archaeal uS10 ribosomal protein and its equivalents in eukaryotes. Ribosomes are the particles that catalyse mRNA-directed protein synthesis in all organisms. The codons of the mRNA are exposed on the ribosome to allow tRNA binding. This leads to the incorporation of amino acids into the growin...

[ "GO:0003735", "GO:0006412", "GO:0015935" ]

[ "structural constituent of ribosome", "translation", "small ribosomal subunit" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "NCBIFAM" ]

[ "TIGR01046" ]

[ "uS10_euk_arch" ]

[ 6074 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-156827", "R-BTA-1799339", "R-BTA-6791226", "R-BTA-72649", "R-BTA-72689", "R-BTA-72695", "R-BTA-72702", "R-BTA-72706", "R-BTA-975956", "R-BTA-975957", "R-DDI-156827", "R-DDI-1799339", "R-DDI-72689", "R-DDI-72695", "R-DDI-72702", "R-DDI-72706", "R-DDI-975956", "R-DDI-975957", ...

[ "REACTOME:R-BTA-156827", "REACTOME:R-BTA-1799339", "REACTOME:R-BTA-6791226", "REACTOME:R-BTA-72649", "REACTOME:R-BTA-72689", "REACTOME:R-BTA-72695", "REACTOME:R-BTA-72702", "REACTOME:R-BTA-72706", "REACTOME:R-BTA-975956", "REACTOME:R-BTA-975957", "REACTOME:R-DDI-156827", "REACTOME:R-DDI-179933...

83

[ "3j6x", "3j6y", "3j77", "3j78", "3j7a", "3j7p", "3j7r", "3j80", "3j81", "3jag", "3jah", "3jai", "3jaj", "3jam", "3jan", "3jap", "3jbn", "3jbo", "3jbp", "4bts", "4d5l", "4d61", "4kzx", "4kzy", "4kzz", "4u3m", "4u3n", "4u3u", "4u4n", "4u4o", "4u4q", "4u4r"...

542

[ "PUB00007068", "PUB00007069", "PUB00007070" ]

[ "11297922", "11290319", "11114498" ]

[ "Atomic structures at last: the ribosome in 2000.", "The ribosome in focus.", "The end of the beginning: structural studies of ribosomal proteins." ]

[ 2001, 2001, 2000 ]

3

[ "IPR001848" ]

[]

1

0

1

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 873, 4, 5168, 29 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 7, 1, 1, 2, 3, 2, 1, 5, 10, 1, 1, 10 ]

12

true

Family

Small ribosomal subunit protein uS10, eukaryotic/archaeal

Ribosomal_uS10_euk/arc

6

IPR005730

5,730

Carboxynorspermidine decarboxylase

Nsp_de-COase

Family

5,405

false

Carboxynorspermidine synthase, mediates the nicotinamide-nucleotide-linked reduction of the Schiff base H2N(CH2)3N = CHCH2CH(NH2)COOH. This is formed from L-aspartic beta-semialdehyde (ASA) and 1,3-diaminopropane (DAP) and is reduced to carboxynorspermidine [H2N(CH2)3NH(CH2)2CH(NH2)COOH], an intermediate in the novel p...

[ "GO:0016831", "GO:0045312" ]

[ "carboxy-lyase activity", "nor-spermidine biosynthetic process" ]

[ "molecular_function", "biological_process" ]

2

[ "PIRSF", "NCBIFAM", "CDD" ]

[ "PIRSF038941", "TIGR01047", "cd06829" ]

[ "NspC", "nspC", "PLPDE_III_CANSDC" ]

[ 5350, 3957, 5338 ]

3

[ "EC", "METACYC", "METACYC" ]

[ "4.1.1.96", "PWY-6559", "PWY-6562" ]

[ "EC:4.1.1.96", "METACYC:PWY-6559", "METACYC:PWY-6562" ]

3

[ "3mt1", "3n29", "9eaf" ]

3

[ "PUB00057880", "PUB00101730" ]

[ "19196710", "22239666" ]

[ "An alternative polyamine biosynthetic pathway is widespread in bacteria and essential for biofilm formation in Vibrio cholerae.", "Elevated levels of the norspermidine synthesis enzyme NspC enhance Vibrio cholerae biofilm formation without affecting intracellular norspermidine concentrations." ]

[ 2009, 2012 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "Methanomicrobia", "metagenomes" ]

[ 5338, 2, 2, 63 ]

4

[]

0

true

Family

Carboxynorspermidine decarboxylase

Nsp_de-COase

6

IPR005732

5,732

Small ribosomal subunit protein uS19, bacteria

Ribosomal_uS19_bact

Family

40,043

false

This entry includes the bacterial and organellar ribosomal protein uS19. The small ribosomal subunit protein S19 contains 88-144 amino acid residues. In Escherichia coli, S19 is known to form a complex with S13 that binds strongly to 16S ribosomal RNA. Experimental evidence [ ] has revealed that S19 is moderately expos...

[ "GO:0003735", "GO:0006412", "GO:0015935" ]

[ "structural constituent of ribosome", "translation", "small ribosomal subunit" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "NCBIFAM" ]

[ "TIGR01050" ]

[ "rpsS_bact" ]

[ 40043 ]

1

[]

0

[ "1fjg", "1fka", "1hnw", "1hnx", "1hnz", "1hr0", "1i94", "1i95", "1i96", "1i97", "1ibk", "1ibl", "1ibm", "1j5e", "1jgo", "1jgp", "1jgq", "1ml5", "1n32", "1n33", "1n34", "1n36", "1qkf", "1qkh", "1vvj", "1vy4", "1vy5", "1vy6", "1vy7", "1xmo", "1xmq", "1xnq"...

1,171

[ "PUB00004907", "PUB00007068", "PUB00007069", "PUB00007070" ]

[ "9371771", "11297922", "11290319", "11114498" ]

[ "Proteins on ribosome surface: measurements of protein exposure by hot tritium bombardment technique.", "Atomic structures at last: the ribosome in 2000.", "The ribosome in focus.", "The end of the beginning: structural studies of ribosomal proteins." ]

[ 1997, 2001, 2001, 2000 ]

4

[ "IPR002222" ]

[]

1

0

1

[ "Bacteria", "Eukaryota", "Thermococcaceae", "unclassified sequences" ]

[ 23053, 16591, 22, 377 ]

4

[ "Arabidopsis thaliana", "Escherichia coli (strain K12)", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 7, 1, 3, 13 ]

4

true

Family

Small ribosomal subunit protein uS19, bacteria

Ribosomal_uS19_bact

1

IPR005733

5,733

DNA topoisomerase I, bacterial-type

TopoI_bac-type

Family

25,912

false

DNA topoisomerases regulate the number of topological links between two DNA strands (i.e. change the number of superhelical turns) by catalysing transient single-or double-strand breaks, crossing the strands through one another, then resealing the breaks [ ]. These enzymes have several functions: to remove DNA supercoi...

[ "GO:0003677", "GO:0003917", "GO:0006265" ]

[ "DNA binding", "DNA topoisomerase type I (single strand cut, ATP-independent) activity", "DNA topological change" ]

[ "molecular_function", "molecular_function", "biological_process" ]

3

[ "NCBIFAM" ]

[ "TIGR01051" ]

[ "topA_bact" ]

[ 25912 ]

1

[ "EC" ]

[ "5.6.2.1" ]

[ "EC:5.6.2.1" ]

1

[ "1cy0", "1cy1", "1cy2", "1cy4", "1cy6", "1cy7", "1cy8", "1ecl", "1mw8", "1mw9", "2gai", "2gaj", "3pwt", "3px7", "4rul", "5d5h", "5uj1", "5ujy", "6cq2", "6cqi", "6ozw", "6pcm", "8czq", "8tfg", "9gda", "9gdb", "9gdc", "9gdd", "9gde", "9gdh" ]

30

[ "PUB00005230", "PUB00005437", "PUB00016766", "PUB00016842", "PUB00020793", "PUB00020794", "PUB00020796", "PUB00081702", "PUB00081703", "PUB00081704", "PUB00081705" ]

[ "9488644", "7770916", "9748482", "11395412", "12596227", "12042765", "14604525", "21087076", "20644584", "17722649", "17293019" ]

[ "Crystal structures of human topoisomerase I in covalent and noncovalent complexes with DNA.", "The mechanisms of DNA topoisomerases.", "Bacterial and archeal type I topoisomerases.", "DNA topoisomerases: structure, function, and mechanism.", "Phylogenomics of type II DNA topoisomerases.", "Cellular roles...

[ 1998, 1995, 1998, 2001, 2003, 2002, 2003, 2010, 2010, 2007, 2007 ]

11

[ "IPR028612" ]

[]

1

0

1

[ "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 24619, 865, 44, 384 ]

4

[ "Arabidopsis thaliana", "Escherichia coli (strain K12)", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 8, 1, 3, 33 ]

4

true

Family

DNA topoisomerase I, bacterial-type

TopoI_bac-type

2

IPR005734

5,734

DNA topoisomerase VI, subunit B

TopoVI_B

Family

1,616

false

This entry represents subunit B of topoisomerase VI, a type IIB topoisomerase found predominantly in archaea, but also in plants [ ]. This enzyme assembles as a heterotetramer, consisting of two A subunits required for DNA cleavage and two B subunits required for ATP hydrolysis. The B subunit is structurally similar to...

[ "GO:0003677", "GO:0003918", "GO:0005524", "GO:0006265" ]

[ "DNA binding", "DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity", "ATP binding", "DNA topological change" ]

[ "molecular_function", "molecular_function", "molecular_function", "biological_process" ]

4

[ "HAMAP", "PIRSF", "NCBIFAM" ]

[ "MF_00322", "PIRSF006553", "TIGR01052" ]

[ "Top6B", "TopoVI_B", "top6b" ]

[ 1606, 522, 888 ]

3

[ "EC" ]

[ "5.6.2.2" ]

[ "EC:5.6.2.2" ]

1

[ "1mu5", "1mx0", "1z59", "1z5a", "1z5b", "1z5c", "2hkj", "2q2e", "2zbk" ]

9

[ "PUB00005437", "PUB00007202", "PUB00016842", "PUB00020793", "PUB00020794", "PUB00020795", "PUB00020804" ]

[ "7770916", "10545127", "11395412", "12596227", "12042765", "7980433", "12618182" ]

[ "The mechanisms of DNA topoisomerases.", "Structure and function of an archaeal topoisomerase VI subunit with homology to the meiotic recombination factor Spo11.", "DNA topoisomerases: structure, function, and mechanism.", "Phylogenomics of type II DNA topoisomerases.", "Cellular roles of DNA topoisomerases...

[ 1995, 1999, 2001, 2003, 2002, 1994, 2003 ]

7

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "ecological metagenomes" ]

[ 904, 87, 610, 15 ]

4

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 5, 1, 4 ]

3

true

Family

DNA topoisomerase VI, subunit B

TopoVI_B

5

IPR005735

5,735

Zinc finger, LSD1-type

Znf_LSD1

Domain

4,008

false

This model describes a zinc finger domain found in three closely spaced copies in Arabidopsis protein LSD1 and in two copies in other proteins from the same species. The domain contains a conserved motif that resembles CxxCRxxLMYxxGASxVxCxxC. This domain was anticipated to play a role in the regulation of transcription...

[]

0

[ "PFAM" ]

[ "PF06943" ]

[ "zf-LSD1" ]

[ 4008 ]

1

[]

0

[]

0

[ "PUB00007887", "PUB00014077", "PUB00035804", "PUB00035805", "PUB00035806", "PUB00035807", "PUB00035812", "PUB00103739", "PUB00151180", "PUB00151181" ]

[ "9054508", "12665246", "17210253", "15963892", "15718139", "10529348", "11179890", "11574472", "28555890", "32409317" ]

[ "A novel zinc finger protein is encoded by the Arabidopsis LSD1 gene and functions as a negative regulator of plant cell death.", "Zinc fingers--folds for many occasions.", "Sticky fingers: zinc-fingers as protein-recognition motifs.", "Multiple modes of RNA recognition by zinc finger proteins.", "Zinc fing...

[ 1997, 2002, 2007, 2005, 2005, 1999, 2001, 2001, 2017, 2020 ]

10

[]

0

null

[ "Bacteria", "Eukaryota" ]

[ 20, 3988 ]

2

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 25, 17, 51 ]

3

true

Domain

Zinc finger, LSD1-type

Znf_LSD1

8

IPR005736

5,736

Reverse gyrase

Reverse_gyrase

Family

520

false

This entry represents reverse gyrases found in both bacteria and archaea. Reverse gyrase, a fusion of a type I topoisomerase domain and a helicase domain, introduces positive supercoiling to increase the melting temperature of DNA double strands. Generally, these gyrases are encoded as a single polypeptide. An exceptio...

[ "GO:0003677", "GO:0003916", "GO:0006265" ]

[ "DNA binding", "DNA topoisomerase activity", "DNA topological change" ]

[ "molecular_function", "molecular_function", "biological_process" ]

3

[ "HAMAP", "PANTHER", "NCBIFAM" ]

[ "MF_01125", "PTHR43505", "TIGR01054" ]

[ "Reverse_gyrase", "", "rgy" ]

[ 383, 520, 481 ]

3

[ "EC" ]

[ "5.6.2.-" ]

[ "EC:5.6.2.-" ]

1

[ "1gku", "1gl9", "3oiy", "3p4x", "3p4y", "4ddt", "4ddu", "4ddv", "4ddw", "4ddx", "7fse", "7fsf", "8ofb" ]

13

[ "PUB00020793" ]

[ "12596227" ]

[ "Phylogenomics of type II DNA topoisomerases." ]

[ 2003 ]

1

[]

0

null

[ "Archaea", "Bacteria" ]

[ 365, 155 ]

2

[]

0

true

Family

Reverse gyrase

Reverse_gyrase

6

IPR005737

5,737

DNA topoisomerase IV, subunit B, Gram-negative

TopoIV_B_Gneg

Family

9,774

false

This entry represents subunit B (parE) of topoisomerase IV from Gram-negative bacteria. Topoisomerase IV primarily decatenates DNA and relaxes positive supercoils, which is important in bacteria, where the circular chromosome becomes catenated, or linked, during replication [ ]. Topoisomerase IV consists of two polypep...

[ "GO:0003677", "GO:0003918", "GO:0005524", "GO:0006265", "GO:0005694" ]

[ "DNA binding", "DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity", "ATP binding", "DNA topological change", "chromosome" ]

[ "molecular_function", "molecular_function", "molecular_function", "biological_process", "cellular_component" ]

5

[ "HAMAP", "PRINTS", "NCBIFAM" ]

[ "MF_00938", "PR01098", "TIGR01055" ]

[ "ParE_type1", "TOPISMRASE4B", "parE_Gneg" ]

[ 9065, 7803, 7952 ]

3

[ "EC", "GP" ]

[ "5.6.2.2", "GenProp1149" ]

[ "EC:5.6.2.2", "GP:GenProp1149" ]

2

[ "1s16", "2xkj", "2xkk", "3fv5", "3lnu", "3lps", "4hxz", "4hy1", "4hym", "4hz0", "4kqv", "5eix", "6waa", "7cmp", "7lhz", "9kgt" ]

16

[ "PUB00005437", "PUB00016842", "PUB00020793", "PUB00020794", "PUB00020795", "PUB00020802" ]

[ "7770916", "11395412", "12596227", "12042765", "7980433", "16023670" ]

[ "The mechanisms of DNA topoisomerases.", "DNA topoisomerases: structure, function, and mechanism.", "Phylogenomics of type II DNA topoisomerases.", "Cellular roles of DNA topoisomerases: a molecular perspective.", "Structure and function of type II DNA topoisomerases.", "The structural basis for substrate...

[ 1995, 2001, 2003, 2002, 1994, 2005 ]

6

[ "IPR001241" ]

[]

1

0

1

[ "Bacteria", "Eukaryota", "Halobacterium salinarum", "Vipetofemvirus", "unclassified sequences" ]

[ 9634, 20, 1, 3, 116 ]

5

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

DNA topoisomerase IV, subunit B, Gram-negative

TopoIV_B_Gneg

6

IPR005738

5,738

DNA topoisomerase III

TopoIII

Family

16,018

false

DNA topoisomerases regulate the number of topological links between two DNA strands (i.e. change the number of superhelical turns) by catalysing transient single-or double-strand breaks, crossing the strands through one another, then resealing the breaks [ ]. These enzymes have several functions: to remove DNA supercoi...

[ "GO:0003677", "GO:0003916", "GO:0006265" ]

[ "DNA binding", "DNA topoisomerase activity", "DNA topological change" ]

[ "molecular_function", "molecular_function", "biological_process" ]

3

[ "HAMAP", "NCBIFAM" ]

[ "MF_00953", "TIGR01056" ]

[ "Topoisom_3_prok", "topB" ]

[ 4395, 16017 ]

2

[ "EC" ]

[ "5.6.2.1" ]

[ "EC:5.6.2.1" ]

1

[ "1d6m", "1i7d", "2o19", "2o54", "2o59", "2o5c", "2o5e" ]

7

[ "PUB00005230", "PUB00005437", "PUB00016842", "PUB00020793", "PUB00020794", "PUB00020797", "PUB00081702", "PUB00081703", "PUB00081704", "PUB00081705" ]

[ "9488644", "7770916", "11395412", "12596227", "12042765", "12509418", "21087076", "20644584", "17722649", "17293019" ]

[ "Crystal structures of human topoisomerase I in covalent and noncovalent complexes with DNA.", "The mechanisms of DNA topoisomerases.", "DNA topoisomerases: structure, function, and mechanism.", "Phylogenomics of type II DNA topoisomerases.", "Cellular roles of DNA topoisomerases: a molecular perspective.",...

[ 1998, 1995, 2001, 2003, 2002, 2003, 2010, 2010, 2007, 2007 ]

10

[ "IPR000380" ]

[]

1

0

1

[ "Bacteria", "Eukaryota", "Siphoviridae sp. ctoWO12", "plasmids", "unclassified sequences" ]

[ 15915, 6, 1, 8, 88 ]

5

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

DNA topoisomerase III

TopoIII

1

IPR005739

5,739

DNA topoisomerase I, archeal-type

TopoI_arch

Family

497

false

This entry describes topoisomerase type I from archaea, which is more closely related to bacterial than to eukaryotic topoisomerase I [ ]. Type I topoisomerases are ATP-independent enzymes (except for reverse gyrase), and can be subdivided according to their structure and reaction mechanisms: type IA (Topo IA; bacteria...

[ "GO:0003677", "GO:0003916", "GO:0006265" ]

[ "DNA binding", "DNA topoisomerase activity", "DNA topological change" ]

[ "molecular_function", "molecular_function", "biological_process" ]

3

[ "NCBIFAM" ]

[ "TIGR01057" ]

[ "topA_arch" ]

[ 497 ]

1

[ "EC" ]

[ "5.6.2.1" ]

[ "EC:5.6.2.1" ]

1

[ "6k8n", "6k8o" ]

2

[ "PUB00005230", "PUB00005437", "PUB00016766", "PUB00016842", "PUB00020793", "PUB00020794", "PUB00081702", "PUB00081703", "PUB00081704", "PUB00081705" ]

[ "9488644", "7770916", "9748482", "11395412", "12596227", "12042765", "21087076", "20644584", "17722649", "17293019" ]

[ "Crystal structures of human topoisomerase I in covalent and noncovalent complexes with DNA.", "The mechanisms of DNA topoisomerases.", "Bacterial and archeal type I topoisomerases.", "DNA topoisomerases: structure, function, and mechanism.", "Phylogenomics of type II DNA topoisomerases.", "Cellular roles...

[ 1998, 1995, 1998, 2001, 2003, 2002, 2010, 2010, 2007, 2007 ]

10

[ "IPR028612" ]

[]

1

0

1

[ "Actinomycetota", "Archaea", "ecological metagenomes" ]

[ 17, 475, 5 ]

3

[]

0

true

Family

DNA topoisomerase I, archeal-type

TopoI_arch

1

IPR005741

5,741

DNA topoisomerase IV subunit A, Gram-positive

TopoIV_A_Gpos

Family

3,667

false

This entry represents subunit A (parC) of topoisomerase IV from Gram-positive bacteria. Topoisomerase IV primarily decatenates DNA and relaxes positive supercoils, which is important in bacteria, where the circular chromosome becomes catenated, or linked, during replication [ ]. Topoisomerase IV consists of two polypep...

[ "GO:0003677", "GO:0003918", "GO:0005524", "GO:0006265", "GO:0005694" ]

[ "DNA binding", "DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity", "ATP binding", "DNA topological change", "chromosome" ]

[ "molecular_function", "molecular_function", "molecular_function", "biological_process", "cellular_component" ]

5

[ "HAMAP", "NCBIFAM" ]

[ "MF_00937", "TIGR01061" ]

[ "ParC_type2", "parC_Gpos" ]

[ 3317, 3667 ]

2

[ "EC" ]

[ "5.6.2.2" ]

[ "EC:5.6.2.2" ]

1

[ "2inr", "2nov", "3foe", "3fof", "3k9f", "3ksa", "3ksb", "3ltn", "3rad", "3rae", "3raf", "4i3h", "4juo", "4koe", "4kpe", "4kpf", "4z3o", "4z4q", "4z53", "8c41", "8qmb", "8qmc", "9gef" ]

23

[ "PUB00005437", "PUB00016842", "PUB00020793", "PUB00020794", "PUB00020795", "PUB00020802" ]

[ "7770916", "11395412", "12596227", "12042765", "7980433", "16023670" ]

[ "The mechanisms of DNA topoisomerases.", "DNA topoisomerases: structure, function, and mechanism.", "Phylogenomics of type II DNA topoisomerases.", "Cellular roles of DNA topoisomerases: a molecular perspective.", "Structure and function of type II DNA topoisomerases.", "The structural basis for substrate...

[ 1995, 2001, 2003, 2002, 1994, 2005 ]

6

[]

0

null

[ "Bacteria", "Ecdysozoa", "human gut metagenome" ]

[ 3663, 2, 2 ]

3

[]

0

true

Family

DNA topoisomerase IV subunit A, Gram-positive

TopoIV_A_Gpos

6

IPR005742

5,742

DNA topoisomerase IV, subunit A, Gram-negative

TopoIV_A_Gneg

Family

9,616

false

This entry represents subunit A (parC) of topoisomerase IV from Gram-negative bacteria. Topoisomerase IV primarily decatenates DNA and relaxes positive supercoils, which is important in bacteria, where the circular chromosome becomes catenated, or linked, during replication [ ]. Topoisomerase IV consists of two polypep...

[ "GO:0003677", "GO:0003918", "GO:0005524", "GO:0006265", "GO:0005694" ]

[ "DNA binding", "DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity", "ATP binding", "DNA topological change", "chromosome" ]

[ "molecular_function", "molecular_function", "molecular_function", "biological_process", "cellular_component" ]

5

[ "HAMAP" ]

[ "MF_00936" ]

[ "ParC_type1" ]

[ 9616 ]

1

[ "EC", "GP" ]

[ "5.6.2.2", "GenProp1149" ]

[ "EC:5.6.2.2", "GP:GenProp1149" ]

2

[ "1zvu" ]

1

[ "PUB00005437", "PUB00016842", "PUB00020793", "PUB00020794", "PUB00020795", "PUB00020802" ]

[ "7770916", "11395412", "12596227", "12042765", "7980433", "16023670" ]

[ "The mechanisms of DNA topoisomerases.", "DNA topoisomerases: structure, function, and mechanism.", "Phylogenomics of type II DNA topoisomerases.", "Cellular roles of DNA topoisomerases: a molecular perspective.", "Structure and function of type II DNA topoisomerases.", "The structural basis for substrate...

[ 1995, 2001, 2003, 2002, 1994, 2005 ]

6

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 9524, 7, 85 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

DNA topoisomerase IV, subunit A, Gram-negative

TopoIV_A_Gneg

8

IPR005743

5,743

DNA gyrase, subunit A

GyrA

Family

26,209

false

Topoisomerase II (called gyrase in bacteria) primarily introduces negative supercoils into DNA. In bacteria, topoisomerase II consists of two polypeptide subunits, gyrA and gyrB, which form a heterotetramer: (BA)2. In most eukaryotes, topoisomerase II consists of a single polypeptide, where the N- and C-terminal region...

[ "GO:0003677", "GO:0003918", "GO:0005524", "GO:0006265", "GO:0005694" ]

[ "DNA binding", "DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity", "ATP binding", "DNA topological change", "chromosome" ]

[ "molecular_function", "molecular_function", "molecular_function", "biological_process", "cellular_component" ]

5

[ "HAMAP" ]

[ "MF_01897" ]

[ "GyrA" ]

[ 26209 ]

1

[ "EC", "GP", "GP", "REACTOME", "REACTOME" ]

[ "5.6.2.2", "GenProp0699", "GenProp1178", "R-HSA-9638771", "R-HSA-9913143" ]

[ "EC:5.6.2.2", "GP:GenProp0699", "GP:GenProp1178", "REACTOME:R-HSA-9638771", "REACTOME:R-HSA-9913143" ]

5

[ "6rks", "6rku", "6rkv", "6rkw", "7z9c", "7z9g", "7z9k", "7z9m", "8qdx", "8qqs", "8qqu", "8s7k", "8s7o", "9gbv", "9ggq" ]

15

[ "PUB00005437", "PUB00016842", "PUB00020793", "PUB00020794", "PUB00020795", "PUB00020803" ]

[ "7770916", "11395412", "12596227", "12042765", "7980433", "8982450" ]

[ "The mechanisms of DNA topoisomerases.", "DNA topoisomerases: structure, function, and mechanism.", "Phylogenomics of type II DNA topoisomerases.", "Cellular roles of DNA topoisomerases: a molecular perspective.", "Structure and function of type II DNA topoisomerases.", "Bacterial diversity based on type ...

[ 1995, 2001, 2003, 2002, 1994, 1996 ]

6

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "metagenomes", "virus sp. ctVE78" ]

[ 488, 25122, 328, 270, 1 ]

5

[ "Arabidopsis thaliana", "Escherichia coli (strain K12)", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 3, 1, 1, 1 ]

4

true

Family

DNA gyrase, subunit A

GyrA

4

IPR005744

5,744

Hly-III

Hy-lIII

Family

14,700

false

This family includes proteins from pathogenic and non-pathogenic bacteria, Homo sapiens (Human) and Drosophila melanogaster (Fruit fly). In Bacillus cereus, a pathogen, it has been show to function as a pore-forming hemolysin [ , ]. Monocyte to macrophage differentiation factor (also known as Macrophage/microglia activ...

[ "GO:0140911", "GO:0016020" ]

[ "pore-forming activity", "membrane" ]

[ "molecular_function", "cellular_component" ]

2

[ "NCBIFAM" ]

[ "TIGR01065" ]

[ "hlyIII" ]

[ 14700 ]

1

[]

0

[]

0

[ "PUB00017626", "PUB00017627", "PUB00019707", "PUB00101957", "PUB00101958" ]

[ "8962879", "7503749", "7495855", "15063720", "16342171" ]

[ "Mechanism of action of hemolysin III from Bacillus cereus.", "Molecular cloning of a novel macrophage maturation-associated transcript encoding a protein with several potential transmembrane domains.", "Cloning and primary structure of a new hemolysin gene from Bacillus cereus.", "Identification of macrophag...

[ 1996, 1995, 1995, 2004, 2006 ]

5

[ "IPR004254" ]

[]

1

0

1

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 3, 12180, 2410, 107 ]

4

[ "Arabidopsis thaliana", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 9, 5, 1, 2, 4, 6 ]

7

true

Family

Hly-III

Hy-lIII

2

IPR005745

5,745

Large ribosomal subunit protein uL14, bacteria

Ribosomal_uL14_bact

Family

39,903

false

Large ribosomal subunit protein uL14 (formerly known as L14) is one of the proteins from the large ribosomal subunit. In bacteria, uL14 is known to bind directly to the 23S rRNA. It belongs to a family of ribosomal proteins which have been grouped on the basis of sequence similarities. uL14 is a protein of 119 to 137 a...

[ "GO:0003735", "GO:0006412", "GO:0015934" ]

[ "structural constituent of ribosome", "translation", "large ribosomal subunit" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "NCBIFAM" ]

[ "TIGR01067" ]

[ "rplN_bact" ]

[ 39903 ]

1

[]

0

[ "1c04", "1ml5", "1nkw", "1nwx", "1nwy", "1sm1", "1vvj", "1vy4", "1vy5", "1vy6", "1vy7", "1whi", "1xbp", "2j28", "2rdo", "2zjp", "2zjq", "2zjr", "3bbx", "3cf5", "3dll", "3iy9", "3izz", "3j3v", "3j3w", "3j5l", "3j6b", "3j7z", "3j8g", "3j9w", "3j9y", "3j9z"...

1,160

[ "PUB00007068", "PUB00007069", "PUB00007070" ]

[ "11297922", "11290319", "11114498" ]

[ "Atomic structures at last: the ribosome in 2000.", "The ribosome in focus.", "The end of the beginning: structural studies of ribosomal proteins." ]

[ 2001, 2001, 2000 ]

3

[ "IPR000218" ]

[]

1

0

1

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 23073, 16437, 393 ]

3

[ "Arabidopsis thaliana", "Escherichia coli (strain K12)", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)", "Zea mays" ]

[ 8, 1, 1, 9, 1, 1, 12 ]

7

true

Family

Large ribosomal subunit protein uL14, bacteria

Ribosomal_uL14_bact

5

IPR005746

5,746

Thioredoxin

Family

60,021

false

This entry represents the thioredoxin protein family. Thioredoxins [ , , , ] are small disulphide-containing redox proteins that have been found in all the kingdoms of living organisms. Thioredoxin serves as a general protein disulphide oxidoreductase. It interacts with a broad range of proteins by a redox mechanism ba...

[ "GO:0015035" ]

[ "protein-disulfide reductase activity" ]

[ "molecular_function" ]

1

[ "PIRSF", "NCBIFAM" ]

[ "PIRSF000077", "TIGR01068" ]

[ "Thioredoxin", "thioredoxin" ]

[ 41842, 52129 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-1614558", "R-BTA-2559580", "R-BTA-3299685", "R-BTA-499943", "R-BTA-5628897", "R-BTA-5676934", "R-BTA-844456", "R-CEL-2559580", "R-CEL-3299685", "R-CEL-499943", "R-CEL-5628897", "R-CEL-5676934", "R-CEL-844456", "R-DDI-3299685", "R-DDI-499943", "R-DDI-5628897", "R-DDI-844456", ...

[ "REACTOME:R-BTA-1614558", "REACTOME:R-BTA-2559580", "REACTOME:R-BTA-3299685", "REACTOME:R-BTA-499943", "REACTOME:R-BTA-5628897", "REACTOME:R-BTA-5676934", "REACTOME:R-BTA-844456", "REACTOME:R-CEL-2559580", "REACTOME:R-CEL-3299685", "REACTOME:R-CEL-499943", "REACTOME:R-CEL-5628897", "REACTOME:R...

74

[ "1aiu", "1auc", "1cqg", "1cqh", "1dby", "1ep7", "1ert", "1eru", "1erv", "1erw", "1f6m", "1f9m", "1faa", "1fb0", "1fb6", "1gl8", "1keb", "1m7t", "1mdi", "1mdj", "1mdk", "1nsw", "1nw2", "1oaz", "1quw", "1rqm", "1skr", "1sks", "1skw", "1sl0", "1sl1", "1sl2"...

267

[ "PUB00000038", "PUB00000561", "PUB00001458", "PUB00001495", "PUB00002504", "PUB00002862", "PUB00002883", "PUB00005250", "PUB00005258", "PUB00005259", "PUB00005423" ]

[ "3896121", "3371540", "7635143", "2537773", "2668278", "7913469", "7983029", "8590004", "7788289", "7788290", "7940678" ]

[ "Thioredoxin.", "Protein disulphide-isomerase: a homologue of thioredoxin implicated in the biosynthesis of secretory proteins.", "Chaperone-like activity of protein disulfide-isomerase in the refolding of rhodanese.", "Protein hydroxylation: prolyl 4-hydroxylase, an enzyme with four cosubstrates and a multif...

[ 1985, 1988, 1995, 1989, 1989, 1994, 1994, 1995, 1995, 1995, 1994 ]

11

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 1448, 47192, 10392, 82, 907 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus",...

[ 29, 3, 3, 8, 2, 5, 3, 2, 11, 4, 2, 1, 32 ]

13

true

Family

Thioredoxin

3

IPR005747

5,747

Endonuclease MutS2

MutS2

Family

12,968

false

This entry represents endonuclease MutS2. MutS2 is a paralogue of MutS and is not involved in DNA mismatch repair but in the suppression of homologous recombination [ , , , ]. It may therefore have a key role in the control of bacterial genetic diversity. The MutS family of proteins is named after the Salmonella typhim...

[ "GO:0004519", "GO:0016887", "GO:0030983", "GO:0045910" ]

[ "endonuclease activity", "ATP hydrolysis activity", "mismatched DNA binding", "negative regulation of DNA recombination" ]

[ "molecular_function", "molecular_function", "molecular_function", "biological_process" ]

4

[ "HAMAP", "PIRSF", "NCBIFAM", "CDD" ]

[ "MF_00092", "PIRSF005814", "TIGR01069", "cd03280" ]

[ "MutS2", "MutS_YshD", "mutS2", "ABC_MutS2" ]

[ 8634, 12438, 12647, 5184 ]

4

[ "EC", "METACYC" ]

[ "3.6.4.-", "PWY-7250" ]

[ "EC:3.6.4.-", "METACYC:PWY-7250" ]

2

[ "7qv3", "7vuf", "7vuk", "8qpp", "8r55", "9kce" ]

6

[ "PUB00042615", "PUB00050421", "PUB00068032", "PUB00068033", "PUB00068769" ]

[ "17965091", "18838375", "15629722", "15866941", "15113836" ]

[ "The origins and early evolution of DNA mismatch repair genes--multiple horizontal gene transfers and co-evolution.", "Crystal structure of MutS2 endonuclease domain and the mechanism of homologous recombination suppression.", "Suppression of homologous and homeologous recombination by the bacterial MutS2 prote...

[ 2007, 2008, 2005, 2005, 2004 ]

5

[ "IPR045076" ]

[]

1

0

1

[ "Bacteria", "Eukaryota", "unclassified Caudoviricetes", "unclassified sequences" ]

[ 11548, 1305, 2, 113 ]

4

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 15, 5, 11 ]

3

true

Family

Endonuclease MutS2

MutS2

5

IPR005748

5,748

DNA mismatch repair protein MutS

DNA_mismatch_repair_MutS

Family

20,974

false

Mismatch repair contributes to the overall fidelity of DNA replication and is essential for combating the adverse effects of damage to the genome. It involves the correction of mismatched base pairs that have been missed by the proofreading element of the DNA polymerase complex. The post-replicative Mismatch Repair Sys...

[ "GO:0005524", "GO:0030983", "GO:0006298" ]

[ "ATP binding", "mismatched DNA binding", "mismatch repair" ]

[ "molecular_function", "molecular_function", "biological_process" ]

3

[ "HAMAP", "NCBIFAM" ]

[ "MF_00096", "TIGR01070" ]

[ "MutS", "mutS1" ]

[ 20049, 20805 ]

2

[ "GP" ]

[ "GenProp0225" ]

[ "GP:GenProp0225" ]

1

[ "1e3m", "1ewq", "1ewr", "1fw6", "1ng9", "1nne", "1oh5", "1oh6", "1oh7", "1oh8", "1w7a", "1wb9", "1wbb", "1wbd", "2wtu", "3k0s", "3zlj", "5akb", "5akc", "5akd", "5x9w", "5yk4", "6i5f", "7ai5", "7ai6", "7ai7", "7aib", "7aic", "7oto", "7ou0", "7ou2", "7ou4"...

32

[ "PUB00004486", "PUB00010188", "PUB00024413", "PUB00042218", "PUB00042612", "PUB00042613", "PUB00042614", "PUB00042615" ]

[ "9722651", "8036718", "11048711", "17426027", "17919654", "17599803", "17951114", "17965091" ]

[ "A phylogenomic study of the MutS family of proteins.", "Colon cancer and DNA repair: have mismatches met their match?", "The crystal structure of DNA mismatch repair protein MutS binding to a G x T mismatch.", "Escherichia coli MutS tetramerization domain structure reveals that stable dimers but not tetramer...

[ 1998, 1994, 2000, 2007, 2007, 2007, 2008, 2007 ]

8

[ "IPR017261" ]

[]

1

0

1

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 791, 19945, 57, 181 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

DNA mismatch repair protein MutS

DNA_mismatch_repair_MutS

9

IPR005749

5,749

Large ribosomal subunit protein uL15, bacteria

Ribosomal_uL15_bact

Family

29,683

false

This entry represents the large ribosomal subunit protein uL15 and homologues found in bacteria, chloroplasts and mitochondria. uL15 is a component of the 50S ribosomal subunit and binds to 23S rRNA. The protein is approximately 133 amino acids and belongs to the universal ribosomal protein uL15 family. It contains an ...

[ "GO:0003735", "GO:0006412", "GO:0015934" ]

[ "structural constituent of ribosome", "translation", "large ribosomal subunit" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PANTHER", "NCBIFAM" ]

[ "PTHR12934", "TIGR01071" ]

[ "", "rplO_bact" ]

[ 29586, 27232 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-5389840", "R-BTA-5419276", "R-BTA-9937383", "R-DRE-5389840", "R-DRE-5419276", "R-HSA-5368286", "R-HSA-5389840", "R-HSA-5419276", "R-HSA-9937383", "R-MMU-5389840", "R-MMU-5419276", "R-MMU-9937383" ]

[ "REACTOME:R-BTA-5389840", "REACTOME:R-BTA-5419276", "REACTOME:R-BTA-9937383", "REACTOME:R-DRE-5389840", "REACTOME:R-DRE-5419276", "REACTOME:R-HSA-5368286", "REACTOME:R-HSA-5389840", "REACTOME:R-HSA-5419276", "REACTOME:R-HSA-9937383", "REACTOME:R-MMU-5389840", "REACTOME:R-MMU-5419276", "REACTOM...

12

[ "1nkw", "1nwx", "1nwy", "1sm1", "1vvj", "1vy4", "1vy5", "1vy6", "1vy7", "1xbp", "2j28", "2rdo", "2zjp", "2zjq", "2zjr", "3bbx", "3cf5", "3dll", "3iy9", "3j3v", "3j3w", "3j5l", "3j6b", "3j7y", "3j7z", "3j8g", "3j9m", "3j9w", "3j9y", "3j9z", "3ja1", "3jbu"...

1,293

[ "PUB00007068", "PUB00007069", "PUB00007070", "PUB00162480" ]

[ "11297922", "11290319", "11114498", "31523176" ]

[ "Atomic structures at last: the ribosome in 2000.", "The ribosome in focus.", "The end of the beginning: structural studies of ribosomal proteins.", "Ribosomal Protein L15 is involved in Colon Carcinogenesis." ]

[ 2001, 2001, 2000, 2019 ]

4

[ "IPR030878" ]

[]

1

0

1

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 23847, 5358, 478 ]

3

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus",...

[ 5, 1, 2, 2, 2, 4, 2, 1, 4, 7, 1, 1, 8 ]

13

true

Family

Large ribosomal subunit protein uL15, bacteria

Ribosomal_uL15_bact

3

IPR005750

5,750

UDP-N-acetylglucosamine 1-carboxyvinyltransferase

UDP_GlcNAc_COvinyl_MurA

Family

34,859

false

The bacterial enzyme UDP-N-acetylglucosamine (UDP-GlcNAc) enolpyruvyltransferase (MurA) catalyzes the transfer of enolpyruvate from phosphoenolpyruvate to uridine diphospho-N-acetylglucosamine, which is the first committed step of bacterial cell wall biosynthesis. Experimental evidence suggests that binding of substrat...

[ "GO:0008760", "GO:0019277" ]

[ "UDP-N-acetylglucosamine 1-carboxyvinyltransferase activity", "UDP-N-acetylgalactosamine biosynthetic process" ]

[ "molecular_function", "biological_process" ]

2

[ "HAMAP", "PANTHER", "NCBIFAM", "CDD" ]

[ "MF_00111", "PTHR43783", "TIGR01072", "cd01555" ]

[ "MurA", "", "murA", "UdpNAET" ]

[ 29325, 34856, 29818, 31045 ]

4

[ "EC", "GP", "GP", "METACYC", "METACYC", "METACYC" ]

[ "2.5.1.7", "GenProp1448", "GenProp1623", "PWY-6386", "PWY-6387", "PWY-7953" ]

[ "EC:2.5.1.7", "GP:GenProp1448", "GP:GenProp1623", "METACYC:PWY-6386", "METACYC:PWY-6387", "METACYC:PWY-7953" ]

6

[ "1a2n", "1dlg", "1ejc", "1ejd", "1eyn", "1naw", "1q3g", "1ryw", "1uae", "1ybg", "2rl1", "2rl2", "2yvw", "2z2c", "3iss", "3kqa", "3kqj", "3kr6", "3lth", "3r38", "3sg1", "3spb", "3su9", "3swa", "3swd", "3swe", "3swg", "3swi", "3swq", "3upk", "3v4t", "3v5v"...

58

[ "PUB00030098" ]

[ "13129913" ]

[ "A new view of the mechanisms of UDP-N-acetylglucosamine enolpyruvyl transferase (MurA) and 5-enolpyruvylshikimate-3-phosphate synthase (AroA) derived from X-ray structures of their tetrahedral reaction intermediate states." ]

[ 2003 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "Inoviridae sp. ctE8B2", "Stenosarchaea group", "unclassified sequences" ]

[ 32820, 1319, 1, 12, 707 ]

5

[ "Escherichia coli (strain K12)", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)" ]

[ 1, 1 ]

2

true

Family

UDP-N-acetylglucosamine 1-carboxyvinyltransferase

UDP_GlcNAc_COvinyl_MurA

3

IPR005751

5,751

ATP-dependent DNA helicase PcrA

ATP-dep_DNA_helicase_PcrA

Family

8,029

false

This entry represents ATP-dependent DNA helicase PcrA in bacteria, winch belongs to the UvrD/Rep helicase family. It has a broad nucleotide specificity, even being able to hydrolyse ethenonucleotides, and is able to couple the hydrolysis to unwinding of DNA substrates. It is a 3'-5' helicase but at high protein concent...

[ "GO:0003678", "GO:0006260", "GO:0005737" ]

[ "DNA helicase activity", "DNA replication", "cytoplasm" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "NCBIFAM" ]

[ "TIGR01073" ]

[ "pcrA" ]

[ 8029 ]

1

[ "EC" ]

[ "5.6.2.4" ]

[ "EC:5.6.2.4" ]

1

[ "1pjr", "1qhg", "2pjr", "3pjr", "9dci", "9des", "9dgy" ]

7

[ "PUB00007888", "PUB00022519", "PUB00060429", "PUB00060430" ]

[ "11165517", "10388562", "9592155", "10454638" ]

[ "Unwinding the 'Gordian knot' of helicase action.", "DNA binding mediates conformational changes and metal ion coordination in the active site of PcrA helicase.", "Characterisation of Bacillus stearothermophilus PcrA helicase: evidence against an active rolling mechanism.", "Site-directed mutagenesis of motif...

[ 2001, 1999, 1998, 1999 ]

4

[ "IPR000212" ]

[]

1

0

1

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 7884, 6, 139 ]

3

[]

0

true

Family

ATP-dependent DNA helicase PcrA

ATP-dep_DNA_helicase_PcrA

3

IPR005752

5,752

ATP-dependent DNA helicase Rep

Helicase_Rep

Family

6,191

false

Rep hexameric DNA helicase contain ATP-binding domains similar to those seen in monomeric helicases but which are arranged in a ring. There is compelling evidence to suggest that a single ssDNA molecule passes through the centre of the hexameric ring. Activity of the enzyme is based upon two separate but coupled activi...

[ "GO:0003677", "GO:0003678", "GO:0005524", "GO:0006260" ]

[ "DNA binding", "DNA helicase activity", "ATP binding", "DNA replication" ]

[ "molecular_function", "molecular_function", "molecular_function", "biological_process" ]

4

[ "HAMAP", "NCBIFAM" ]

[ "MF_01920", "TIGR01074" ]

[ "Helicase_Rep", "rep" ]

[ 6170, 4146 ]

2

[ "EC", "GP" ]

[ "5.6.2.4", "GenProp1208" ]

[ "EC:5.6.2.4", "GP:GenProp1208" ]

2

[ "1uaa" ]

1

[ "PUB00007888" ]

[ "11165517" ]

[ "Unwinding the 'Gordian knot' of helicase action." ]

[ 2001 ]

1

[ "IPR000212" ]

[]

1

0

1

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 6148, 4, 39 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

ATP-dependent DNA helicase Rep

Helicase_Rep

1

IPR005754

5,754

Sortase family

Sortase

Family

34,530

false

This family includes Staphylococcus aureus sortase, a transpeptidase that attaches surface proteins by the Thr of an LPXTG motif to the cell wall. It also includes a protein required for correct assembly of an LPXTG-containing fimbrial protein, a set of homologous proteins from Streptococcus pneumoniae, in which LPXTG ...

[]

0

[ "PFAM", "NCBIFAM" ]

[ "PF04203", "TIGR01076" ]

[ "Sortase", "sortase_fam" ]

[ 34502, 16747 ]

2

[ "EC", "GP" ]

[ "3.4.22.-", "GenProp0626" ]

[ "EC:3.4.22.-", "GP:GenProp0626" ]

2

[ "1ija", "1ng5", "1qwz", "1qx6", "1qxa", "1rz2", "1t2o", "1t2p", "1t2w", "2kid", "2kw8", "2ln7", "2mlm", "2oqw", "2oqz", "2rui", "2w1j", "2w1k", "2wts", "2xwg", "3fn5", "3fn6", "3fn7", "3g66", "3g69", "3o0p", "3psq", "3rbi", "3rbj", "3rbk", "3rcc", "3re9"...

85

[ "PUB00007890", "PUB00014494", "PUB00014495", "PUB00060431", "PUB00060432", "PUB00060433" ]

[ "10427003", "11401711", "14572546", "2544515", "2519520", "18321961" ]

[ "Staphylococcus aureus sortase, an enzyme that anchors surface proteins to the cell wall.", "Sortase-catalysed anchoring of surface proteins to the cell wall of Staphylococcus aureus.", "Genomic analysis of secretion systems.", "Stimulation of clones specific for dsDNA or idiotypes of anti-dsDNA as a conseque...

[ 1999, 2001, 2003, 1989, 1989, 2008 ]

6

[]

[ "IPR009835", "IPR041999", "IPR042000", "IPR042001", "IPR042002", "IPR042003", "IPR042007" ]

0

7

0

[ "Bacteria", "Eukaryota", "Methanomada group", "Viruses", "unclassified sequences" ]

[ 34127, 8, 82, 2, 311 ]

5

[ "Arabidopsis thaliana" ]

[ 1 ]

1

true

Family

Sortase family

Sortase

5

IPR005755

5,755

Large ribosomal subunit protein uL13, eukaryota/archaea

Ribosomal_uL13_euk_arc

Family

6,413

false

Ribosomal protein uL13 is one of the proteins from the large ribosomal subunit [ ]. This entry represents ribosomal protein of uL13 from archaea and from the eukaryotic cytosol. Ribosomes are the particles that catalyse mRNA-directed protein synthesis in all organisms. The codons of the mRNA are exposed on the ribosome...

[ "GO:0003735", "GO:0006412", "GO:0015934" ]

[ "structural constituent of ribosome", "translation", "large ribosomal subunit" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "NCBIFAM" ]

[ "TIGR01077" ]

[ "L13_A_E" ]

[ 6413 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-156827", "R-BTA-1799339", "R-BTA-6791226", "R-BTA-72689", "R-BTA-72706", "R-BTA-975956", "R-BTA-975957", "R-CEL-156827", "R-CEL-1799339", "R-CEL-72689", "R-CEL-72706", "R-CEL-975956", "R-CEL-975957", "R-DDI-156827", "R-DDI-1799339", "R-DDI-72689", "R-DDI-72706", "R-DDI-97595...

[ "REACTOME:R-BTA-156827", "REACTOME:R-BTA-1799339", "REACTOME:R-BTA-6791226", "REACTOME:R-BTA-72689", "REACTOME:R-BTA-72706", "REACTOME:R-BTA-975956", "REACTOME:R-BTA-975957", "REACTOME:R-CEL-156827", "REACTOME:R-CEL-1799339", "REACTOME:R-CEL-72689", "REACTOME:R-CEL-72706", "REACTOME:R-CEL-9759...

64

[ "1ffk", "1j3a", "1jj2", "1k73", "1k8a", "1k9m", "1kc8", "1kd1", "1kqs", "1m1k", "1m90", "1ml5", "1n8r", "1nji", "1q7y", "1q81", "1q82", "1q86", "1qvf", "1qvg", "1s72", "1vq4", "1vq5", "1vq6", "1vq7", "1vq8", "1vq9", "1vqk", "1vql", "1vqm", "1vqn", "1vqo"...

687

[ "PUB00002889", "PUB00007068", "PUB00007069", "PUB00007070" ]

[ "8119894", "11297922", "11290319", "11114498" ]

[ "A leucine zipper-like motif and a basic region-leucine zipper-like element in rat ribosomal protein L13a. Identification of the tum- transplantation antigen P198.", "Atomic structures at last: the ribosome in 2000.", "The ribosome in focus.", "The end of the beginning: structural studies of ribosomal protein...

[ 1994, 2001, 2001, 2000 ]

4

[ "IPR005822" ]

[]

1

0

1

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 910, 3, 5470, 30 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 13, 1, 2, 2, 11, 11, 2, 5, 7, 2, 3, 14 ]

12

true

Family

Large ribosomal subunit protein uL13, eukaryota/archaea

Ribosomal_uL13_euk_arc

6

IPR005756

5,756

Large ribosomal subunit protein uL24, eukaryota_archaea

Ribosomal_uL24_euk_arc

Family

7,050

false

Ribosomal protein uL24 is one of the proteins from the large ribosomal subunit. In their mature form, these proteins have 103 to 150 amino-acid residues. The eukaryotic uL24 is a conserved protein that shares significant sequence and structure similarity with archaeal and eubacterial uL24. This entry represents the arc...

[ "GO:0003735", "GO:0006412", "GO:0015934" ]

[ "structural constituent of ribosome", "translation", "large ribosomal subunit" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "HAMAP", "PFAM", "PANTHER", "NCBIFAM" ]

[ "MF_01326_A", "PF16906", "PTHR11143", "TIGR01080" ]

[ "Ribosomal_uL24_A", "Ribosomal_L26", "", "rplX_A_E" ]

[ 3810, 6995, 6905, 6908 ]

4

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-156827", "R-BTA-1799339", "R-BTA-6791226", "R-BTA-72689", "R-BTA-72706", "R-BTA-975956", "R-BTA-975957", "R-CEL-156827", "R-CEL-1799339", "R-CEL-72689", "R-CEL-72706", "R-CEL-975956", "R-CEL-975957", "R-DDI-156827", "R-DDI-1799339", "R-DDI-72689", "R-DDI-72706", "R-DDI-97595...

[ "REACTOME:R-BTA-156827", "REACTOME:R-BTA-1799339", "REACTOME:R-BTA-6791226", "REACTOME:R-BTA-72689", "REACTOME:R-BTA-72706", "REACTOME:R-BTA-975956", "REACTOME:R-BTA-975957", "REACTOME:R-CEL-156827", "REACTOME:R-CEL-1799339", "REACTOME:R-CEL-72689", "REACTOME:R-CEL-72706", "REACTOME:R-CEL-9759...

58

[ "1ffk", "1jj2", "1k73", "1k8a", "1k9m", "1kc8", "1kd1", "1kqs", "1m1k", "1m90", "1ml5", "1n8r", "1nji", "1q7y", "1q81", "1q82", "1q86", "1qvf", "1qvg", "1s72", "1vq4", "1vq5", "1vq6", "1vq7", "1vq8", "1vq9", "1vqk", "1vql", "1vqm", "1vqn", "1vqo", "1vqp"...

692

[ "PUB00007068", "PUB00007069", "PUB00007070", "PUB00152528" ]

[ "11297922", "11290319", "11114498", "22431104" ]

[ "Atomic structures at last: the ribosome in 2000.", "The ribosome in focus.", "The end of the beginning: structural studies of ribosomal proteins.", "Frameshift mutation in p53 regulator RPL26 is associated with multiple physical abnormalities and a specific pre-ribosomal RNA processing defect in diamond-blac...

[ 2001, 2001, 2000, 2012 ]

4

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 927, 5, 6072, 46 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 5, 2, 1, 1, 11, 5, 1, 11, 10, 2, 1, 21 ]

12

true

Family

Large ribosomal subunit protein uL24, eukaryota_archaea

Ribosomal_uL24_euk_arc

2

IPR005757

5,757

Murein peptide ligase

Mpl

Family

7,006

false

The tripeptide L-ananyl-gamma-D-glutamyl-meso-diaminopimelic acid is efficiently re-cycled during the formation of bacterial cell wall murein. Murein peptide ligase (also known as UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl-meso-diaminopimelate ligase) is an essential enzyme in this process which links the tripeptid...

[ "GO:0016881", "GO:0009252", "GO:0071555" ]

[ "acid-amino acid ligase activity", "peptidoglycan biosynthetic process", "cell wall organization" ]

[ "molecular_function", "biological_process", "biological_process" ]

3

[ "HAMAP", "NCBIFAM" ]

[ "MF_02020", "TIGR01081" ]

[ "Mpl", "mpl" ]

[ 6439, 6984 ]

2

[ "GP" ]

[ "GenProp1623" ]

[ "GP:GenProp1623" ]

1

[ "3eag", "3hn7" ]

2

[ "PUB00017629" ]

[ "8808921" ]

[ "Identification of the mpl gene encoding UDP-N-acetylmuramate: L-alanyl-gamma-D-glutamyl-meso-diaminopimelate ligase in Escherichia coli and its role in recycling of cell wall peptidoglycan." ]

[ 1996 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 6892, 15, 99 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Murein peptide ligase

Mpl

7