LiteFold/InterPro · Datasets at Hugging Face

IPR006747

6,747

Protein of unknown function DUF599

DUF599

Family

7,515

false

This family includes several uncharacterised proteins.

[]

0

[ "PFAM" ]

[ "PF04654" ]

[ "DUF599" ]

[ 7515 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "metagenomes" ]

[ 5, 3128, 4361, 21 ]

4

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 32, 21, 19 ]

3

true

Family

Protein of unknown function DUF599

DUF599

3

IPR006748

6,748

Aminoglycoside/hydroxyurea antibiotic resistance kinase

NH2Glyco/OHUrea_AB-resist_kin

Family

7,185

false

The aminoglycosides are a large group of biologically active bacterial secondary metabolites, best known for their antibiotic properties [ ]. Aminoglycoside phosphotransferases achieve inactivation of these enzymes by phosphorylation, utilising ATP. Likewise, hydroxyurea is inactivated by phosphorylation of the hydroxy...

[ "GO:0016773", "GO:0006468", "GO:0019748" ]

[ "phosphotransferase activity, alcohol group as acceptor", "protein phosphorylation", "secondary metabolic process" ]

[ "molecular_function", "biological_process", "biological_process" ]

3

[ "PFAM" ]

[ "PF04655" ]

[ "APH_6_hur" ]

[ 7185 ]

1

[]

0

[]

0

[ "PUB00007992" ]

[ "9211644" ]

[ "Bacterial resistance to aminoglycoside antibiotics." ]

[ 1997 ]

1

[]

0

null

[ "Bacteria", "Opisthokonta", "plasmids", "unclassified sequences" ]

[ 7167, 3, 2, 13 ]

4

[]

0

true

Family

Aminoglycoside/hydroxyurea antibiotic resistance kinase

NH2Glyco/OHUrea_AB-resist_kin

7

IPR006749

6,749

Pox virus E6 protein

Pox_E6

Family

156

false

This family contains fowlpox virus protein E6 and its homologues, including Protein OPG068 from Vaccinia virus. OPG068 plays an essential role for maintaining proper localization of the seven-protein complex and the viroplasm during assembly [ , , ].

[]

0

[ "PFAM", "PIRSF" ]

[ "PF04656", "PIRSF015629" ]

[ "Pox_E6", "VAC_E6R" ]

[ 156, 148 ]

2

[]

0

[]

0

[ "PUB00009823", "PUB00103582", "PUB00103583", "PUB00103584", "PUB00103585" ]

[ "10729156", "19217136", "20116821", "25863879", "20116822" ]

[ "The genome of fowlpox virus.", "Expression of the highly conserved vaccinia virus E6 protein is required for virion morphogenesis.", "The E6 protein from vaccinia virus is required for the formation of immature virions.", "The vaccinia virus E6 protein influences virion protein localization during virus asse...

[ 2000, 2009, 2010, 2015, 2010 ]

5

[]

0

null

[ "Poxviridae" ]

[ 156 ]

1

[]

0

true

Family

Pox virus E6 protein

Pox_E6

6

IPR006750

6,750

Putative inner membrane exporter, YdcZ

YdcZ

Family

14,676

false

DMT_YdcZ is a family of putative inner membrane exporters from both Gram-positive and Gram-negative bacteria.

[]

0

[ "PFAM", "PANTHER" ]

[ "PF04657", "PTHR34821" ]

[ "DMT_YdcZ", "" ]

[ 14676, 14421 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Methanobacteriati", "unclassified sequences" ]

[ 14189, 274, 21, 192 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Putative inner membrane exporter, YdcZ

YdcZ

7

IPR006751

6,751

TAFII55 protein, conserved region

TAFII55_prot_cons_reg

Domain

5,072

false

The general transcription factor, TFIID, consists of the TATA-binding protein (TBP) associated with a series of TBP-associated factors (TAFs) that together participate in the assembly of the transcription preinitiation complex. TAFII55 binds to TAFII250 and inhibits its acetyltransferase activity. The exact role of TAF...

[ "GO:0006367", "GO:0005669" ]

[ "transcription initiation at RNA polymerase II promoter", "transcription factor TFIID complex" ]

[ "biological_process", "cellular_component" ]

2

[ "PFAM", "SMART", "CDD" ]

[ "PF04658", "SM01370", "cd08047" ]

[ "TAFII55_N", "TAFII55_N", "TAF7" ]

[ 5062, 5022, 4732 ]

3

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-DME-674695", "R-DME-6804756", "R-DME-73776", "R-DME-73779", "R-DME-75953", "R-DME-76042", "R-HSA-167161", "R-HSA-167162", "R-HSA-167172", "R-HSA-674695", "R-HSA-6804756", "R-HSA-73776", "R-HSA-73779", "R-HSA-75953", "R-HSA-76042", "R-MMU-674695", "R-MMU-6804756", "R-MMU-73776", ...

[ "REACTOME:R-DME-674695", "REACTOME:R-DME-6804756", "REACTOME:R-DME-73776", "REACTOME:R-DME-73779", "REACTOME:R-DME-75953", "REACTOME:R-DME-76042", "REACTOME:R-HSA-167161", "REACTOME:R-HSA-167162", "REACTOME:R-HSA-167172", "REACTOME:R-HSA-674695", "REACTOME:R-HSA-6804756", "REACTOME:R-HSA-73776...

31

[ "4oy2", "4rgw", "5fur", "6mzl", "6mzm", "7edx", "7eg7", "7eg8", "7eg9", "7ega", "7egb", "7egc", "7egd", "7ege", "7egh", "7egi", "7egj", "7ena", "7enc", "8gxq", "8gxs", "8wak", "8wal", "8wan", "8wao", "8wap", "8waq", "8war", "8was" ]

29

[ "PUB00008521" ]

[ "11592977" ]

[ "TAFII55 binding to TAFII250 inhibits its acetyltransferase activity." ]

[ 2001 ]

1

[]

0

null

[ "Eukaryota" ]

[ 5072 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 3, 2, 1, 4, 3, 6, 1, 7, 9, 1, 1, 25 ]

12

true

Domain

TAFII55 protein, conserved region

TAFII55_prot_cons_reg

3

IPR006752

6,752

Archaeal flagella protein FlaD/E domain

Arch_fla_DE

Domain

756

false

Archaeal flagella are unique motility structures, and the absence of bacterial structural motility genes in the complete genome sequences of flagellated archaeal species has always suggested that archaeal flagellar biogenesis is likely mediated by novel components. FlaD and FlaE, are present in the cell as membrane-ass...

[ "GO:0097588" ]

[ "archaeal or bacterial-type flagellum-dependent cell motility" ]

[ "biological_process" ]

1

[ "PFAM" ]

[ "PF04659" ]

[ "Arch_fla_DE" ]

[ 756 ]

1

[]

0

[]

0

[ "PUB00008522" ]

[ "11717274" ]

[ "Characterization of flagellum gene families of methanogenic archaea and localization of novel flagellum accessory proteins." ]

[ 2001 ]

1

[]

0

null

[ "Archaea", "Neocallimastix californiae", "candidate division WOR-3 bacterium", "unclassified sequences" ]

[ 750, 2, 1, 3 ]

4

[]

0

true

Domain

Archaeal flagella protein FlaD/E domain

Arch_fla_DE

2

IPR006753

6,753

Nanovirus coat protein

Nanovirus_coat

Family

326

false

This is a family of conserved coat proteins from the single stranded DNA Nanoviruses [ ].

[]

0

[ "PFAM" ]

[ "PF04660" ]

[ "Nanovirus_coat" ]

[ 326 ]

1

[]

0

[ "6s44" ]

1

[ "PUB00008523" ]

[ "10795525" ]

[ "Sequence variability in the coat protein gene of two groups of banana bunchy top isolates." ]

[ 2000 ]

1

[]

0

null

[ "Nanoviridae" ]

[ 326 ]

1

[]

0

true

Family

Nanovirus coat protein

Nanovirus_coat

2

IPR006754

6,754

Poxvirus I3 ssDNA-binding

Poxvirus_I3_ssDNA-bd

Family

172

false

The 34kDa protein encoded by the I3 gene of vaccinia virus, named Protein OPG079, is expressed at early and intermediate times post-infection and is phosphorylated on serine residues. I3 protein demonstrates a striking affinity for single-stranded, but not for double-stranded, DNA. Electrophoretic mobility shift assays...

[ "GO:0003697" ]

[ "single-stranded DNA binding" ]

[ "molecular_function" ]

1

[ "PFAM", "PIRSF" ]

[ "PF04661", "PIRSF003767" ]

[ "Pox_I3", "VAC_I3L" ]

[ 172, 159 ]

2

[]

0

[]

0

[ "PUB00007993", "PUB00103586" ]

[ "9525612", "26773382" ]

[ "Characterization of the single-stranded DNA binding protein encoded by the vaccinia virus I3 gene.", "The acidic C-terminus of vaccinia virus I3 single-strand binding protein promotes proper assembly of DNA-protein complexes." ]

[ 1998, 2016 ]

2

[]

0

null

[ "Poxviridae" ]

[ 172 ]

1

[]

0

true

Family

Poxvirus I3 ssDNA-binding

Poxvirus_I3_ssDNA-bd

4

IPR006755

6,755

Suppressor of silencing P0

Virus_P0

Family

507

false

P0 is a suppressor of RNA-mediated gene silencing, also known as post-transcriptional gene silencing (PTGS), a mechanism of plant viral defense that limits the accumulation of viral RNAs. It targets ARGONAUTE proteins for degradation [ ]. It may prevent RNA-induced silencing complex (RISC) assembly by interacting with ...

[ "GO:0016032" ]

[ "viral process" ]

[ "biological_process" ]

1

[ "PFAM" ]

[ "PF04662" ]

[ "Luteo_PO" ]

[ 507 ]

1

[]

0

[]

0

[ "PUB00084349", "PUB00099684" ]

[ "17869110", "20128884" ]

[ "The Polerovirus silencing suppressor P0 targets ARGONAUTE proteins for degradation.", "Polerovirus protein P0 prevents the assembly of small RNA-containing RISC complexes and leads to degradation of ARGONAUTE1." ]

[ 2007, 2010 ]

2

[]

0

null

[ "Viruses" ]

[ 507 ]

1

[]

0

true

Family

Suppressor of silencing P0

Virus_P0

2

IPR006756

6,756

Phenol hydroxylase

Phenol_hydroxylase

Family

680

false

Under aerobic conditions, phenol is usually hydroxylated to catechol and degraded via the meta or ortho pathways. Two types of phenol hydroxylase are known: one is a multi-component enzyme, such as Phenol 2-monooxygenase, oxygenase component DmpO from Pseudomonas sp. [ ], the other is a single-component monooxygenase. ...

[ "GO:0018662" ]

[ "phenol 2-monooxygenase activity" ]

[ "molecular_function" ]

1

[ "PFAM" ]

[ "PF04663" ]

[ "Phenol_monoox" ]

[ 680 ]

1

[]

0

[ "2inn", "2inp", "3u52" ]

3

[ "PUB00002124", "PUB00009003", "PUB00100255" ]

[ "2254258", "11571188", "12186554" ]

[ "Complete nucleotide sequence and polypeptide analysis of multicomponent phenol hydroxylase from Pseudomonas sp. strain CF600.", "Genetic and functional analysis of the tbc operons for catabolism of alkyl- and chloroaromatic compounds in Burkholderia sp. strain JS150.", "Biochemical, Mossbauer, and EPR studies ...

[ 1990, 2001, 2002 ]

3

[]

0

null

[ "Bacteria", "Cyprideis torosa", "unclassified sequences" ]

[ 672, 1, 7 ]

3

[]

0

true

Family

Phenol hydroxylase

Phenol_hydroxylase

2

IPR006757

6,757

Opioid growth factor receptor (OGFr)-like, conserved domain

OGF_rcpt

Domain

3,702

false

Opioid peptides act as growth factors in neural and non-neural cells and tissues, in addition to serving in neurotransmission/neuromodulation in the nervous system. The opioid growth factor receptor is an integral membrane protein associated with the nucleus. This conserved domain is situated at the N terminus of the m...

[ "GO:0038023", "GO:0016020" ]

[ "signaling receptor activity", "membrane" ]

[ "molecular_function", "cellular_component" ]

2

[ "PFAM" ]

[ "PF04664" ]

[ "OGFr_N" ]

[ 3702 ]

1

[]

0

[]

0

[ "PUB00008525", "PUB00163283" ]

[ "11890982", "37957213" ]

[ "The biology of the opioid growth factor receptor (OGFr).", "Functional and structural diversity in deubiquitinases of the Chlamydia-like bacterium Simkania negevensis." ]

[ 2002, 2023 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "Marseillevirus LCMAC202", "metagenomes" ]

[ 330, 3363, 1, 8 ]

4

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 9, 10, 6, 10 ]

4

true

Domain

Opioid growth factor receptor (OGFr)-like, conserved domain

OGF_rcpt

2

IPR006758

6,758

Poxvirus A32

A32L

Family

2,049

false

The A32 protein from Vaccinia virus, also known as DNA packaging protein OPG160, is thought to be involved in viral DNA packaging [ ].

[]

0

[ "PFAM" ]

[ "PF04665" ]

[ "Pox_A32" ]

[ 2049 ]

1

[]

0

[]

0

[ "PUB00020148" ]

[ "9621036" ]

[ "DNA packaging mutant: repression of the vaccinia virus A32 gene results in noninfectious, DNA-deficient, spherical, enveloped particles." ]

[ 1998 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 7, 1677, 278, 87 ]

4

[]

0

true

Family

Poxvirus A32

A32L

6

IPR006759

6,759

Glycosyl transferase family 54

Glyco_transf_54

Family

7,233

false

The complex-type of oligosaccharides are synthesised through elongation by glycosyltransferases after trimming of the precursor oligosaccharides transferred to proteins in the endoplasmic reticulum. N-Acetylglucosaminyltransferases (GnTs) take part in the formation of branches in the biosynthesis of complex-type sugar ...

[]

0

[ "PANTHER" ]

[ "PTHR12062" ]

[ "" ]

[ 7233 ]

1

[ "CAZY", "EC", "GP", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME",...

[ "GT54", "2.4.1.145", "GenProp1524", "PWY-7426", "R-BTA-381426", "R-BTA-8957275", "R-BTA-975577", "R-DRE-975577", "R-GGA-381426", "R-GGA-8957275", "R-GGA-975577", "R-HSA-381426", "R-HSA-8957275", "R-HSA-9694548", "R-HSA-975577", "R-MMU-381426", "R-MMU-8957275", "R-MMU-975577", "R-...

[ "CAZY:GT54", "EC:2.4.1.145", "GP:GenProp1524", "METACYC:PWY-7426", "REACTOME:R-BTA-381426", "REACTOME:R-BTA-8957275", "REACTOME:R-BTA-975577", "REACTOME:R-DRE-975577", "REACTOME:R-GGA-381426", "REACTOME:R-GGA-8957275", "REACTOME:R-GGA-975577", "REACTOME:R-HSA-381426", "REACTOME:R-HSA-8957275...

25

[ "7vmt", "7xtl", "7xtm", "7xtn" ]

4

[ "PUB00008526", "PUB00088406" ]

[ "9278430", "26371870" ]

[ "Purification and characterization of UDP-N-acetylglucosamine: alpha1,3-D-mannoside beta1,4-N-acetylglucosaminyltransferase (N-acetylglucosaminyltransferase-IV) from bovine small intestine.", "GnT1IP-L specifically inhibits MGAT1 in the Golgi via its luminal domain." ]

[ 1997, 2015 ]

2

[]

0

null

[ "Eukaryota" ]

[ 7233 ]

1

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 10, 5, 19, 14, 25 ]

5

true

Family

Glycosyl transferase family 54

Glyco_transf_54

6

IPR006761

6,761

Tsg

Family

1,668

false

Twisted gastrulation (Tsg) was identified in Drosophila melanogaster as being required to specify the dorsal-most structures in the embryo, for example, the amnioserosa. Biochemical experiments have revealed three key properties of Tsg: It can synergistically inhibit Dpp/BMP action in both D. melanogaster and vertebrat...

[]

0

[ "PANTHER" ]

[ "PTHR12312" ]

[ "" ]

[ 1668 ]

1

[]

0

[ "8bwa", "8bwd", "8bwi", "8bwl", "8bwm", "8bwn" ]

6

[ "PUB00008529", "PUB00008530" ]

[ "7958834", "11260716" ]

[ "Dorsal midline fate in Drosophila embryos requires twisted gastrulation, a gene encoding a secreted protein related to human connective tissue growth factor.", "Twisted gastrulation is a conserved extracellular BMP antagonist." ]

[ 1994, 2001 ]

2

[]

0

null

[ "Eumetazoa" ]

[ 1668 ]

1

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 6, 4, 2, 2, 2 ]

5

true

Family

Tsg

9

IPR006762

6,762

Gtr1/RagA G protein

Gtr1_RagA

Family

9,682

false

GTR1 was first identified in Saccharomyces cerevisiae (Baker's yeast) as a suppressor of a mutation in RCC1. RCC1 catalyzes guanine nucleotide exchange on Ran, a well characterised nuclear Ras-like small G protein that plays an essential role in the import and export of proteins and RNAs across the nuclear membrane thr...

[ "GO:0005525" ]

[ "GTP binding" ]

[ "molecular_function" ]

1

[ "PFAM", "PANTHER" ]

[ "PF04670", "PTHR11259" ]

[ "Gtr1_RagA", "" ]

[ 9614, 9476 ]

2

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", ...

[ "3.6.5.-", "R-BTA-1632852", "R-BTA-165159", "R-BTA-166208", "R-BTA-380972", "R-BTA-5628897", "R-BTA-8866654", "R-BTA-8943724", "R-BTA-9639288", "R-DDI-1632852", "R-DDI-165159", "R-DDI-166208", "R-DDI-380972", "R-DDI-5628897", "R-DDI-8866654", "R-DDI-8943724", "R-DDI-9639288", "R-HS...

[ "EC:3.6.5.-", "REACTOME:R-BTA-1632852", "REACTOME:R-BTA-165159", "REACTOME:R-BTA-166208", "REACTOME:R-BTA-380972", "REACTOME:R-BTA-5628897", "REACTOME:R-BTA-8866654", "REACTOME:R-BTA-8943724", "REACTOME:R-BTA-9639288", "REACTOME:R-DDI-1632852", "REACTOME:R-DDI-165159", "REACTOME:R-DDI-166208",...

44

[ "2q3f", "3llu", "3r7w", "4arz", "5x6v", "6ces", "6ehr", "6jwp", "6nzd", "6s6a", "6s6d", "6sb0", "6sb2", "6u62", "6ulg", "6wj2", "6wj3", "7t3a", "7t3b", "7t3c", "7ux2", "7uxc", "7uxh", "8dhb", "8fw5", "8yl2", "9ed4", "9ed6", "9h4q", "9h5k" ]

30

[ "PUB00007995" ]

[ "11073942" ]

[ "Novel G proteins, Rag C and Rag D, interact with GTP-binding proteins, Rag A and Rag B." ]

[ 2001 ]

1

[]

[ "IPR039397", "IPR039400" ]

0

2

0

[ "Bacteria", "Eukaryota", "Promethearchaeati", "marine sediment metagenome" ]

[ 48, 9469, 50, 115 ]

4

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strai...

[ 3, 7, 2, 7, 7, 3, 18, 2, 2 ]

9

true

Family

Gtr1/RagA G protein

Gtr1_RagA

7

IPR006763

6,763

Antigen 332 repeat

Ag332

Repeat

41

false

To date many different Plasmodium antigens recognised by the hyperimmune system human sera have been cloned, sequenced and characterised. The majority contain tandemly repeated amino acid sequences which make up a considerable portion of the protein sequence. It has been suggested that these repeat-containing antigens ...

[]

0

[ "PFAM" ]

[ "PF04671" ]

[ "Ag332" ]

[ 41 ]

1

[]

0

[]

0

[ "PUB00008531" ]

[ "7628570" ]

[ "Plasmodium falciparum: D260, an intraerythrocytic parasite protein, is a member of the glutamic acid dipeptide-repeat family of proteins." ]

[ 1995 ]

1

[]

0

null

[ "Plasmodium (Laverania)" ]

[ 41 ]

1

[]

0

true

Repeat

Antigen 332 repeat

Ag332

9

IPR006764

6,764

S-adenosyl-L-methionine dependent methyltransferase, SAV2177 type

SAM_dep_MeTrfase_SAV2177_type

Family

18,672

false

This family contains a SAM (S-adenosyl methyltransferase) domain, with a central β sheet with 3 α-helices on both sides. Crystal packing analysis of the structure of suggests that a monomer is the solution state oligomeric form. An unidentified ligand (UNL, cyan) was found at the putative active site surrounded by the ...

[]

0

[ "PFAM", "PIRSF" ]

[ "PF04672", "PIRSF017393" ]

[ "Methyltransf_19", "MTase_SAV2177" ]

[ 18672, 17478 ]

2

[]

0

[ "2qe6", "3giw", "3go4" ]

3

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "ecological metagenomes" ]

[ 18618, 52, 2 ]

3

[]

0

true

Family

S-adenosyl-L-methionine dependent methyltransferase, SAV2177 type

SAM_dep_MeTrfase_SAV2177_type

1

IPR006765

6,765

Polyketide synthesis cyclase

Polyketide_synth_cyclase

Family

1,740

false

Aromatic polyketides are assembled by a type II (iterative) polyketide synthases (PKSs) in bacteria. Type II PKS complexes consist of several monofunctional or bifunctional proteins which produce polyketide chains of variable but defined length from a specific starter unit and a number of extender units. They also spec...

[ "GO:0030639" ]

[ "polyketide biosynthetic process" ]

[ "biological_process" ]

1

[ "PFAM" ]

[ "PF04673" ]

[ "Cyclase_polyket" ]

[ 1740 ]

1

[]

0

[ "1tuw", "8is2" ]

2

[ "PUB00014069", "PUB00020610", "PUB00075002", "PUB00075003" ]

[ "12514126", "15231835", "19903160", "9224566" ]

[ "The structure of ActVA-Orf6, a novel type of monooxygenase involved in actinorhodin biosynthesis.", "Structural and functional analysis of tetracenomycin F2 cyclase from Streptomyces glaucescens. A type II polyketide cyclase.", "Biosynthesis of bacterial aromatic polyketides.", "Iterative type II polyketide ...

[ 2003, 2004, 2009, 1997 ]

4

[]

0

null

[ "Bacteria" ]

[ 1740 ]

1

[]

0

true

Family

Polyketide synthesis cyclase

Polyketide_synth_cyclase

6

IPR006766

6,766

Protein EXORDIUM-like

EXORDIUM-like

Family

6,519

false

This entry includes the EXORDIUM protein and related proteins. The EXO (EXORDIUM) gene was identified as a potential mediator of brassinosteroid (BR)-promoted growth [ ]. It mediates cell expansion in Arabidopsis leaves [ ]. This entry also includes PHI-1, a phosphate-induced protein of unknown function from Nicotiana ...

[]

0

[ "PFAM", "PANTHER" ]

[ "PF04674", "PTHR31279" ]

[ "Phi_1", "" ]

[ 6514, 6348 ]

2

[]

0

[]

0

[ "PUB00008532", "PUB00086678", "PUB00086679" ]

[ "10189698", "19216774", "15063727" ]

[ "Phosphate as a limiting factor for the cell division of tobacco BY-2 cells.", "The extracellular EXO protein mediates cell expansion in Arabidopsis leaves.", "EXORDIUM regulates brassinosteroid-responsive genes." ]

[ 1999, 2009, 2004 ]

3

[]

0

null

[ "Bacteria", "Eukaryota", "ecological metagenomes" ]

[ 37, 6472, 10 ]

3

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 25, 40, 35 ]

3

true

Family

Protein EXORDIUM-like

EXORDIUM-like

9

IPR006767

6,767

Cwf19-like protein, C-terminal domain-2

Cwf19-like_C_dom-2

Domain

8,140

false

This group of sequences contain a conserved C-terminal domain which is found in the Schizosaccharomyces pombe (Fission yeast) protein Cwf19 ( ) and its homologues. Cwf19 is part of the Cdc5p complex involved in mRNA splicing [ ]. CWF19-like protein DRN1 from Saccharomyces cerevisiae ( ) is involved branched RNA metabol...

[]

0

[ "PFAM" ]

[ "PF04676" ]

[ "CwfJ_C_2" ]

[ 8140 ]

1

[ "REACTOME" ]

[ "R-HSA-72163" ]

[ "REACTOME:R-HSA-72163" ]

1

[ "3jb9", "6id0", "6id1", "8ro1", "8ro2", "9l5r" ]

6

[ "PUB00008533", "PUB00090681" ]

[ "11884590", "24919400" ]

[ "Proteomics analysis reveals stable multiprotein complexes in both fission and budding yeasts containing Myb-related Cdc5p/Cef1p, novel pre-mRNA splicing factors, and snRNAs.", "A homolog of lariat-debranching enzyme modulates turnover of branched RNA." ]

[ 2002, 2014 ]

2

[]

0

null

[ "Eukaryota" ]

[ 8140 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 11, 2, 4, 5, 4, 2, 2, 7, 8, 1, 2, 10 ]

12

true

Domain

Cwf19-like protein, C-terminal domain-2

Cwf19-like_C_dom-2

8

IPR006769

6,769

Calcium uniporter protein, C-terminal

MCU_C

Domain

7,351

false

This entry represents the C-terminal domain of MCU, which is a mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria [ , , ]. This domain can also be found in MCUb, which negatively regulates the activity of MCU [ ]. It is also found in Chloroplastic calcium uniporter protein fro...

[]

0

[ "PFAM" ]

[ "PF04678" ]

[ "MCU" ]

[ 7351 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-CEL-8949215", "R-CEL-8949664", "R-DDI-8949215", "R-DME-8949215", "R-DME-8949664", "R-HSA-8949215", "R-HSA-8949664", "R-MMU-8949215", "R-MMU-8949664" ]

[ "REACTOME:R-CEL-8949215", "REACTOME:R-CEL-8949664", "REACTOME:R-DDI-8949215", "REACTOME:R-DME-8949215", "REACTOME:R-DME-8949664", "REACTOME:R-HSA-8949215", "REACTOME:R-HSA-8949664", "REACTOME:R-MMU-8949215", "REACTOME:R-MMU-8949664" ]

9

[ "5id3", "6c5w", "6d7w", "6d80", "6dnf", "6dt0", "6k7x", "6k7y", "6o58", "6o5b", "6wdn", "6wdo", "6x4s", "6xjv", "6xjx", "6xqn" ]

16

[ "PUB00088836", "PUB00088837", "PUB00088838", "PUB00088839", "PUB00154569" ]

[ "21685888", "21685886", "23101630", "23900286", "31182842" ]

[ "A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter.", "Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter.", "MICU1 is an essential gatekeeper for MCU-mediated mitochondrial Ca(2+) uptake that regulates cell survival.", "T...

[ 2011, 2011, 2012, 2013, 2019 ]

5

[]

0

null

[ "Eukaryota", "Pseudomonadati", "bioreactor metagenome" ]

[ 7346, 4, 1 ]

3

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 28, 1, 2, 1, 4, 4, 1, 14, 6, 18 ]

10

true

Domain

Calcium uniporter protein, C-terminal

MCU_C

4

IPR006770

6,770

Opioid growth factor receptor, disordered repeat

OGF_rcpt_rpt

Repeat

42

false

Opioid peptides act as growth factors in neural and non-neural cells and tissues, in addition to serving for neurotransmission/neuromodulation in the nervous system. The native opioid growth factor (OGF), [Met(5)]-enkephalin, is an inhibitory peptide that plays a role in cell proliferation and tissue organisation durin...

[]

0

[ "PFAM" ]

[ "PF04680" ]

[ "OGFr_III" ]

[ 42 ]

1

[]

0

[]

0

[ "PUB00008525" ]

[ "11890982" ]

[ "The biology of the opioid growth factor receptor (OGFr)." ]

[ 2002 ]

1

[]

0

null

[ "Simiiformes" ]

[ 42 ]

1

[ "Homo sapiens" ]

[ 6 ]

1

true

Repeat

Opioid growth factor receptor, disordered repeat

OGF_rcpt_rpt

2

IPR006771

6,771

Secreted thaumatin-like protein cetA-like

CetA-like

Family

2,878

false

This entry represents a group of proteins from ascomycetes, including Secreted thaumatin-like protein cetA from Emericella nidulans. Together with CalA, CetA plays an essential role in early conidial germination with a possible role in cell wall remodelling [ , ]. The structure has been solved for a member of this fami...

[]

0

[ "PFAM" ]

[ "PF04681" ]

[ "Bys1" ]

[ 2878 ]

1

[]

0

[ "5fid" ]

1

[ "PUB00008535", "PUB00154344", "PUB00154345", "PUB00154346" ]

[ "11811639", "16376592", "17703972", "27507984" ]

[ "Genetic diversity and transcriptional analysis of the bys1 gene from Blastomyces dermatitidis.", "Analysis of the Aspergillus nidulans thaumatin-like cetA gene and evidence for transcriptional repression of pyr4 expression in the cetA-disrupted strain.", "The Aspergillus nidulans cetA and calA genes are involv...

[ 2001, 2006, 2008, 2016 ]

4

[]

0

null

[ "Eukaryota" ]

[ 2878 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)" ]

[ 1 ]

1

true

Family

Secreted thaumatin-like protein cetA-like

CetA-like

3

IPR006772

6,772

Herpesvirus BTRF1 protein

Herpes_BTRF1

Family

102

false

This is a family of Herpesvirus proteins of unknown function.

[]

0

[ "PFAM" ]

[ "PF04682" ]

[ "Herpes_BTRF1" ]

[ 102 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Herpesvirales" ]

[ 102 ]

1

[]

0

true

Family

Herpesvirus BTRF1 protein

Herpes_BTRF1

7

IPR006773

6,773

Proteasomal ubiquitin receptor Rpn13/ADRM1

Rpn13/ADRM1

Family

6,253

false

This entry includes Rpn13 from budding yeasts and its homologue, ADRM1 from animals. Rpn13 is a subunit and an ubiquitin receptor of the 19S regulatory particle of the 26S proteasome lid. The 26S proteasome is a huge macromolecular protein-degradation machine consisting of a proteolytically active 20S core, in the form...

[ "GO:0005634", "GO:0005737" ]

[ "nucleus", "cytoplasm" ]

[ "cellular_component", "cellular_component" ]

2

[ "PANTHER" ]

[ "PTHR12225" ]

[ "" ]

[ 6253 ]

1

[ "GP", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", ...

[ "GenProp2012", "R-BTA-1169091", "R-BTA-1234176", "R-BTA-1236978", "R-BTA-174084", "R-BTA-174154", "R-BTA-174178", "R-BTA-174184", "R-BTA-187577", "R-BTA-195253", "R-BTA-202424", "R-BTA-2467813", "R-BTA-2871837", "R-BTA-349425", "R-BTA-350562", "R-BTA-382556", "R-BTA-450408", "R-BTA...

[ "GP:GenProp2012", "REACTOME:R-BTA-1169091", "REACTOME:R-BTA-1234176", "REACTOME:R-BTA-1236978", "REACTOME:R-BTA-174084", "REACTOME:R-BTA-174154", "REACTOME:R-BTA-174178", "REACTOME:R-BTA-174184", "REACTOME:R-BTA-187577", "REACTOME:R-BTA-195253", "REACTOME:R-BTA-202424", "REACTOME:R-BTA-2467813...

394

[ "2kqz", "2kr0", "2l5v", "2mkz", "2nbv", "2r2y", "2z4d", "2z59", "3jco", "3jcp", "4cr2", "4cr3", "4cr4", "4uel", "4uem", "4wlq", "4wlr", "5a5b", "5irs", "5mpb", "5mpc", "5mpd", "5mpe", "5v1y", "5v1z", "5wvi", "5wvk", "5ymy", "6co4", "6fvt", "6fvu", "6fvv"...

50

[ "PUB00049233", "PUB00053442", "PUB00054318" ]

[ "18497827", "18497817", "20471946" ]

[ "Ubiquitin docking at the proteasome through a novel pleckstrin-homology domain interaction.", "Proteasome subunit Rpn13 is a novel ubiquitin receptor.", "Structure of proteasome ubiquitin receptor hRpn13 and its activation by the scaffolding protein hRpn2." ]

[ 2008, 2008, 2010 ]

3

[]

0

null

[ "Eukaryota" ]

[ 6253 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 8, 2, 4, 19, 5, 4, 2, 4, 4, 1, 2, 13 ]

12

true

Family

Proteasomal ubiquitin receptor Rpn13/ADRM1

Rpn13/ADRM1

1

IPR006775

6,775

Glycosyl-hydrolase family 116, catalytic region

GH116_catalytic

Domain

6,397

false

This entry represents the catalytic region found in the CAZyme GH116 family members, which presently includes enzymes with beta-glucosidase ( ), beta-xylosidase ( ) , and glucocerebrosidase ( ) activity [ ]. Proteins containing this domain include animal non-lysosomal glucosylceramidase GBA2, which catalyse the convers...

[ "GO:0004553" ]

[ "hydrolase activity, hydrolyzing O-glycosyl compounds" ]

[ "molecular_function" ]

1

[ "PFAM" ]

[ "PF04685" ]

[ "DUF608" ]

[ 6397 ]

1

[ "EC", "EC", "EC", "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", ...

[ "2.4.1.-", "3.2.1.-", "3.2.1.45", "3.2.1.46", "PWY-1901", "PWY-1921", "PWY-1961", "PWY-1981", "PWY-2021", "PWY-2881", "PWY-2901", "PWY-2902", "PWY-4421", "PWY-4801", "PWY-5094", "PWY-5105", "PWY-5129", "PWY-5139", "PWY-5160", "PWY-5161", "PWY-5268", "PWY-5284", "PWY-5286"...

[ "EC:2.4.1.-", "EC:3.2.1.-", "EC:3.2.1.45", "EC:3.2.1.46", "METACYC:PWY-1901", "METACYC:PWY-1921", "METACYC:PWY-1961", "METACYC:PWY-1981", "METACYC:PWY-2021", "METACYC:PWY-2881", "METACYC:PWY-2901", "METACYC:PWY-2902", "METACYC:PWY-4421", "METACYC:PWY-4801", "METACYC:PWY-5094", "METACYC...

234

[ "5bvu", "5bx2", "5bx3", "5bx4", "5bx5", "5fjs", "5npf", "5o0s", "5ost", "7dks", "7dkt", "7dku", "7dkv", "7dkw", "7dkx", "7dky", "7w2s", "7w2t", "7w2v", "7w2w", "7w2x", "8i5o", "8i5p", "8i5q", "8i5r", "8i5s", "8i5t", "8i5u", "8ic6", "8ic7", "8jbo", "8r06"...

33

[ "PUB00044658", "PUB00044659", "PUB00073615", "PUB00078737" ]

[ "17105727", "17080196", "20427274", "23332917" ]

[ "Identification of the non-lysosomal glucosylceramidase as beta-glucosidase 2.", "Mutation of beta-glucosidase 2 causes glycolipid storage disease and impaired male fertility.", "A new archaeal beta-glycosidase from Sulfolobus solfataricus: seeding a novel retaining beta-glycan-specific glycoside hydrolase fami...

[ 2007, 2006, 2010, 2013 ]

4

[]

0

null

[ "Bacteria", "Eukaryota", "Thermoproteati", "unclassified sequences" ]

[ 1683, 4549, 128, 37 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 30, 5, 1, 5, 4, 1, 15, 3, 36 ]

9

true

Domain

Glycosyl-hydrolase family 116, catalytic region

GH116_catalytic

1

IPR006776

6,776

Sporulation-specific cell division protein SsgB

SsgB

Family

7,122

false

SsgB is a conserved activator of developmental cell division in morphologically complex actinomycetes [ ]. It controls cell division and spore maturation in streptomycetes. Together with SsgA, SsgB activates sporulation-specific cell division by controlling the localisation of FtsZ [ ]. SsgB shows structural similarity...

[ "GO:0051301" ]

[ "cell division" ]

[ "biological_process" ]

1

[ "PFAM" ]

[ "PF04686" ]

[ "SsgA" ]

[ 7122 ]

1

[]

0

[ "3cm1", "6slc", "6suj" ]

3

[ "PUB00054507", "PUB00077088" ]

[ "19567872", "26002075" ]

[ "Structural and functional characterizations of SsgB, a conserved activator of developmental cell division in morphologically complex actinomycetes.", "Transcriptional analysis of the cell division-related ssg genes in Streptomyces coelicolor reveals direct control of ssgR by AtrA." ]

[ 2009, 2015 ]

2

[]

0

null

[ "Actinomycetes", "Caudoviricetes", "Rhynchospora breviuscula", "metagenomes" ]

[ 7099, 15, 1, 7 ]

4

[]

0

true

Family

Sporulation-specific cell division protein SsgB

SsgB

1

IPR006777

6,777

Minor spike protein

Microvir_H

Family

382

false

This entry represents the minor spike protein (also known as H protein), which is a minor spike component of the viral shell. It is involved in the ejection of the phage DNA in the host and is injected with the DNA in the periplasmic space of the host. It is involved in the determination of the phage host-range [ , ].

[ "GO:0046718" ]

[ "symbiont entry into host cell" ]

[ "biological_process" ]

1

[ "PFAM", "PIRSF" ]

[ "PF04687", "PIRSF004160" ]

[ "Microvir_H", "Microvir_H" ]

[ 382, 323 ]

2

[]

0

[ "4jpn", "4jpp" ]

2

[ "PUB00008541", "PUB00008542", "PUB00008543", "PUB00062408", "PUB00066808" ]

[ "8158636", "10225278", "8433365", "10739948", "16143459" ]

[ "Analysis of the single-stranded DNA bacteriophage phi X174, refined at a resolution of 3.0 A.", "Specific interaction of fused H protein of bacteriophage phiX174 with receptor lipopolysaccharides.", "Role of DNA-protein interactions in bacteriophage phi X174 DNA injection.", "Characterization of the binding ...

[ 1994, 1999, 1993, 2000, 2005 ]

5

[]

0

null

[ "Bacteria", "Bullavirinae", "Eukaryota", "Methanomicrobia" ]

[ 212, 109, 59, 2 ]

4

[]

0

true

Family

Minor spike protein

Microvir_H

7

IPR006779

6,779

DNA binding protein S1FA

S1FA_DNA-bd

Family

856

false

S1FA is an unusual small plant peptide of only 70 amino acids with a basic domain which contains a nuclear localization signal and a putative DNA binding helix. S1FA is highly conserved between dicotyledonous and monocotyledonous plants and may be a DNA-binding protein that specifically recognises the negative promoter...

[ "GO:0003677", "GO:0006355", "GO:0005634" ]

[ "DNA binding", "regulation of DNA-templated transcription", "nucleus" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PFAM", "PANTHER" ]

[ "PF04689", "PTHR35298" ]

[ "S1FA", "" ]

[ 856, 765 ]

2

[]

0

[]

0

[ "PUB00008544" ]

[ "7739894" ]

[ "Molecular cloning of a small DNA binding protein with specificity for a tissue-specific negative element within the rps1 promoter." ]

[ 1995 ]

1

[]

0

null

[ "Candidatus Enterococcus mansonii", "Eukaryota", "Methanothermococcus okinawensis" ]

[ 1, 854, 1 ]

3

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 8, 3, 8 ]

3

true

Family

DNA binding protein S1FA

S1FA_DNA-bd

9

IPR006780

6,780

YABBY protein

YABBY

Family

5,111

false

YABBY proteins are a group of plant-specific transcription factors involved in diverse aspects of leaf, shoot and flower development [ , , ].

[ "GO:0007275" ]

[ "multicellular organism development" ]

[ "biological_process" ]

1

[ "PANTHER" ]

[ "PTHR31675" ]

[ "" ]

[ 5111 ]

1

[]

0

[]

0

[ "PUB00008545", "PUB00008546", "PUB00074508" ]

[ "10679447", "11858837", "21974722" ]

[ "The YABBY gene family and abaxial cell fate.", "Establishment of polarity in angiosperm lateral organs.", "Evolution of the YABBY gene family with emphasis on the basal eudicot Eschscholzia californica (Papaveraceae)." ]

[ 2000, 2002, 2012 ]

3

[]

0

null

[ "Eukaryota", "Viruses", "viral metagenome" ]

[ 5107, 3, 1 ]

3

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 28, 22, 72 ]

3

true

Family

YABBY protein

YABBY

4

IPR006781

6,781

Apolipoprotein C-I

ApoC-I

Family

442

false

Exchangeable apolipoproteins are water-soluble protein components of lipoproteins that solubilise lipids and regulate their metabolism by binding to cell receptors or activating specific enzymes. Apolipoprotein C-I (ApoC-1) is the smallest exchangeable apolipoprotein and transfers among HDL (high density lipoprotein), ...

[ "GO:0042157", "GO:0005576" ]

[ "lipoprotein metabolic process", "extracellular region" ]

[ "biological_process", "cellular_component" ]

2

[ "PFAM", "PANTHER" ]

[ "PF04691", "PTHR16565" ]

[ "ApoC-I", "" ]

[ 425, 432 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-CFA-8866423", "R-CFA-8964046", "R-HSA-8866423", "R-HSA-8964046", "R-HSA-9029569", "R-MMU-8866423", "R-MMU-8964046", "R-RNO-8866423", "R-RNO-8964046" ]

[ "REACTOME:R-CFA-8866423", "REACTOME:R-CFA-8964046", "REACTOME:R-HSA-8866423", "REACTOME:R-HSA-8964046", "REACTOME:R-HSA-9029569", "REACTOME:R-MMU-8866423", "REACTOME:R-MMU-8964046", "REACTOME:R-RNO-8866423", "REACTOME:R-RNO-8964046" ]

9

[ "1alf", "1eze", "1ioj", "1opp", "6dvu", "6dxr", "6dz6", "6nf3" ]

8

[ "PUB00008547", "PUB00008548", "PUB00008549" ]

[ "11580293", "11353333", "11741391" ]

[ "Solution conformation of human apolipoprotein C-1 inferred from proline mutagenesis: far- and near-UV CD study.", "Apolipoproteins C-I and C-III as important modulators of lipoprotein metabolism.", "Apolipoprotein C-I expression in the brain in Alzheimer's disease." ]

[ 2001, 2001, 2001 ]

3

[]

0

null

[ "Bilateria" ]

[ 442 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 6, 1, 4 ]

4

true

Family

Apolipoprotein C-I

ApoC-I

4

IPR006782

6,782

Platelet-derived growth factor, N-terminal

PDGF_N

Domain

2,244

false

Platelet-derived growth factor (PDGF) [ , ] is a potent mitogen for cells of mesenchymal origin, including smooth muscle cells and glial cells. In both mouse and human, the PDGF signalling network consists of four ligands, PDGFA-D, and two receptors, PDGFRalpha and PDGFRbeta. All PDGFs function as secreted, disulphide-...

[ "GO:0008083", "GO:0016020" ]

[ "growth factor activity", "membrane" ]

[ "molecular_function", "cellular_component" ]

2

[ "PFAM" ]

[ "PF04692" ]

[ "PDGF_N" ]

[ 2244 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-114608", "R-BTA-1257604", "R-BTA-186763", "R-BTA-186797", "R-BTA-5673001", "R-BTA-6811558", "R-CFA-114608", "R-CFA-1257604", "R-CFA-186763", "R-CFA-186797", "R-CFA-5673001", "R-CFA-6811558", "R-HSA-114608", "R-HSA-1257604", "R-HSA-186763", "R-HSA-186797", "R-HSA-2219530", "R...

[ "REACTOME:R-BTA-114608", "REACTOME:R-BTA-1257604", "REACTOME:R-BTA-186763", "REACTOME:R-BTA-186797", "REACTOME:R-BTA-5673001", "REACTOME:R-BTA-6811558", "REACTOME:R-CFA-114608", "REACTOME:R-CFA-1257604", "REACTOME:R-CFA-186763", "REACTOME:R-CFA-186797", "REACTOME:R-CFA-5673001", "REACTOME:R-CF...

33

[ "3mjg", "3mjk" ]

2

[ "PUB00000590", "PUB00001228", "PUB00014075" ]

[ "2546599", "1425569", "12952899" ]

[ "Structure and function of platelet-derived growth factor (PDGF) and related proteins.", "Structural and functional studies on platelet-derived growth factor.", "Roles of PDGF in animal development." ]

[ 1989, 1992, 2003 ]

3

[]

0

null

[ "Vertebrata", "Woolly monkey sarcoma virus" ]

[ 2242, 2 ]

2

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 4, 11, 9, 13 ]

4

true

Domain

Platelet-derived growth factor, N-terminal

PDGF_N

4

IPR006783

6,783

Transposase, ISC1217

Transposase_ISC1217

Family

448

false

Autonomous mobile genetic elements such as transposon or insertion sequences (IS) encode an enzyme, transposase, that is required for excising and inserting the mobile element. Transposases have been grouped into various families [ , , ]. This family includes the putative transposase ISC1217 from archaebacteria.

[]

0

[ "PFAM" ]

[ "PF04693" ]

[ "DDE_Tnp_2" ]

[ 448 ]

1

[]

0

[]

0

[ "PUB00001812", "PUB00003820", "PUB00004452" ]

[ "1718819", "1310791", "8041625" ]

[ "IS406 and IS407, two gene-activating insertion sequences for Pseudomonas cepacia.", "Isolation and analysis of IS6120, a new insertion sequence from Mycobacterium smegmatis.", "Sequence similarity of putative transposases links the maize Mutator autonomous element and a group of bacterial insertion sequences."...

[ 1991, 1992, 1994 ]

3

[]

0

null

[ "Adineta steineri", "Archaea", "Bacteria", "metagenomes" ]

[ 1, 293, 133, 21 ]

4

[]

0

true

Family

Transposase, ISC1217

Transposase_ISC1217

1

IPR006784

6,784

Coronavirus Orf3

Coronavirus_Orf3

Family

205

false

This family represents the Coronavirus ORF3 protein, also known as the X2A protein.

[]

0

[ "PFAM" ]

[ "PF04694" ]

[ "Corona_3" ]

[ 205 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Coronaviridae" ]

[ 205 ]

1

[]

0

true

Family

Coronavirus Orf3

Coronavirus_Orf3

2

IPR006785

6,785

Peroxisome membrane anchor protein Pex14p, N-terminal

Pex14_N

Domain

6,262

false

This conserved region defines a group of peroxisomal membrane anchor proteins which bind the PTS1 (peroxisomal targeting signal) receptor and are required for the import of PTS1-containing proteins into peroxisomes. Loss of functional Pex14p results in defects in both the PTS1 and PTS2-dependent import pathways. Deleti...

[]

0

[ "PFAM" ]

[ "PF04695" ]

[ "Pex14_N" ]

[ 6262 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-DDI-8866654", "R-DDI-9033241", "R-DDI-9603798", "R-HSA-8866654", "R-HSA-9033241", "R-HSA-9603798", "R-MMU-8866654", "R-MMU-9033241", "R-MMU-9603798", "R-RNO-8866654", "R-RNO-9033241", "R-RNO-9603798", "R-SCE-8866654", "R-SCE-9033241", "R-SCE-9603798", "R-SPO-8866654", "R-SPO-90332...

[ "REACTOME:R-DDI-8866654", "REACTOME:R-DDI-9033241", "REACTOME:R-DDI-9603798", "REACTOME:R-HSA-8866654", "REACTOME:R-HSA-9033241", "REACTOME:R-HSA-9603798", "REACTOME:R-MMU-8866654", "REACTOME:R-MMU-9033241", "REACTOME:R-MMU-9603798", "REACTOME:R-RNO-8866654", "REACTOME:R-RNO-9033241", "REACTOM...

18

[ "2w84", "2w85", "3ff5", "4bxu", "5aon", "5l87", "5l8a", "5mmc", "5n8v", "5oml", "6rt2", "6s6r", "6s7m", "6s9y", "6spt", "6zfw", "7qrc", "8gi0", "8rib" ]

19

[ "PUB00008550", "PUB00008551" ]

[ "9094717", "11564741" ]

[ "Pex14p, a peroxisomal membrane protein binding both receptors of the two PTS-dependent import pathways.", "Peroxisome biogenesis and selective degradation converge at Pex14p." ]

[ 1997, 2001 ]

2

[]

0

null

[ "Eukaryota", "Shewanella sairae" ]

[ 6261, 1 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 4, 1, 2, 1, 2, 2, 2, 8, 4, 1, 1, 58 ]

12

true

Domain

Peroxisome membrane anchor protein Pex14p, N-terminal

Pex14_N

2

IPR006786

6,786

Pinin/SDK/MemA protein

Pinin_SDK_MemA

Domain

4,219

false

This conserved region is located adjacent and C-terminal to a N-terminal pinin/SKD domain . Members of this family have very varied localisations within the eukaryotic cell. Pinin is known to localise at the desmosomes and is implicated in anchoring intermediate filaments to the desmosomal plaque [ ]. SDK2/3 is a dynam...

[]

0

[ "PFAM" ]

[ "PF04696" ]

[ "Pinin_SDK_memA" ]

[ 4219 ]

1

[ "REACTOME", "REACTOME" ]

[ "R-HSA-72163", "R-MMU-72163" ]

[ "REACTOME:R-HSA-72163", "REACTOME:R-MMU-72163" ]

2

[]

0

[ "PUB00008552", "PUB00008553", "PUB00008554" ]

[ "8922384", "9447706", "10095061" ]

[ "Characterization of pinin, a novel protein associated with the desmosome-intermediate filament complex.", "Evidence that \"pinin\", reportedly a differentiation-specific desmosomal protein, is actually a widespread nuclear protein.", "memA/DRS, a putative mediator of multiprotein complexes, is overexpressed in...

[ 1996, 1997, 1999 ]

3

[]

0

null

[ "Empedobacter brevis", "Eukaryota" ]

[ 2, 4217 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Schizosaccharomyces pombe (stra...

[ 11, 1, 3, 3, 2, 3, 1, 5, 3, 2, 14 ]

11

true

Domain

Pinin/SDK/MemA protein

Pinin_SDK_MemA

4

IPR006787

6,787

Pinin/SDK

Pinin_SDK_N

Domain

1,209

false

This conserved region is found at the N-terminal of the member proteins. It is located adjacent and N-terminal to the pinin/SKD/memA domain . Members of this family have very varied localisations within the eukaryotic cell. Pinin is known to localise at the desmosomes and is implicated in anchoring intermediate filamen...

[]

0

[ "PFAM" ]

[ "PF04697" ]

[ "Pinin_SDK_N" ]

[ 1209 ]

1

[ "REACTOME", "REACTOME" ]

[ "R-HSA-72163", "R-MMU-72163" ]

[ "REACTOME:R-HSA-72163", "REACTOME:R-MMU-72163" ]

2

[]

0

[ "PUB00008552", "PUB00008553", "PUB00009010", "PUB00009011" ]

[ "8922384", "9447706", "12051732", "10645008" ]

[ "Characterization of pinin, a novel protein associated with the desmosome-intermediate filament complex.", "Evidence that \"pinin\", reportedly a differentiation-specific desmosomal protein, is actually a widespread nuclear protein.", "Modulation of alternative pre-mRNA splicing in vivo by pinin.", "Character...

[ 1996, 1997, 2002, 2000 ]

4

[]

0

null

[ "Eumetazoa" ]

[ 1209 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 3, 4, 4, 3 ]

4

true

Domain

Pinin/SDK

Pinin_SDK_N

9

IPR006788

6,788

Rab effector MyRIP/Melanophilin

Myrip/Melanophilin

Domain

3,132

false

This is a mostly disordered region, with some α-helices, found in Rab effector MyRIP and melanophilin. They are both Rab effector proteins involved in melanosome transport [ , ].

[]

0

[ "PFAM" ]

[ "PF04698" ]

[ "Rab_eff_C" ]

[ 3132 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-264876", "R-HSA-9824585", "R-MMU-9824585", "R-RNO-9824585" ]

[ "REACTOME:R-HSA-264876", "REACTOME:R-HSA-9824585", "REACTOME:R-MMU-9824585", "REACTOME:R-RNO-9824585" ]

4

[]

0

[ "PUB00061615", "PUB00061616" ]

[ "17827149", "11887186" ]

[ "MyRIP anchors protein kinase A to the exocyst complex.", "Identification of an organelle receptor for myosin-Va." ]

[ 2007, 2002 ]

2

[]

0

null

[ "Bilateria" ]

[ 3132 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 22, 8, 6, 12 ]

4

true

Domain

Rab effector MyRIP/Melanophilin

Myrip/Melanophilin

7

IPR006789

6,789

Actin-related protein 2/3 complex subunit 5

ARPC5

Family

5,264

false

Arp2/3 binds to pre-existing actin filaments and nucleates new daughter filaments, and thus becomes incorporated into the dynamic actin network at the leading edge of motile cells and other actin-based protrusive structures [ ]. In order to nucleate filaments, Arp2/3 must bind to a member of the N-WASp/SCAR family prot...

[ "GO:0034314", "GO:0005885", "GO:0015629" ]

[ "Arp2/3 complex-mediated actin nucleation", "Arp2/3 protein complex", "actin cytoskeleton" ]

[ "biological_process", "cellular_component", "cellular_component" ]

3

[ "PFAM", "PIRSF", "PANTHER" ]

[ "PF04699", "PIRSF039096", "PTHR12644" ]

[ "P16-Arc", "p16-ARC", "" ]

[ 5233, 2839, 5090 ]

3

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-DDI-2029482", "R-DDI-5663213", "R-DDI-6798695", "R-HSA-2029482", "R-HSA-3928662", "R-HSA-5663213", "R-HSA-6798695", "R-HSA-8856828", "R-HSA-9664422", "R-MMU-2029482", "R-MMU-3928662", "R-MMU-5663213", "R-MMU-6798695", "R-MMU-8856828", "R-RNO-2029482", "R-RNO-3928662", "R-RNO-56632...

[ "REACTOME:R-DDI-2029482", "REACTOME:R-DDI-5663213", "REACTOME:R-DDI-6798695", "REACTOME:R-HSA-2029482", "REACTOME:R-HSA-3928662", "REACTOME:R-HSA-5663213", "REACTOME:R-HSA-6798695", "REACTOME:R-HSA-8856828", "REACTOME:R-HSA-9664422", "REACTOME:R-MMU-2029482", "REACTOME:R-MMU-3928662", "REACTOM...

26

[ "1k8k", "1tyq", "1u2v", "2p9i", "2p9k", "2p9l", "2p9n", "2p9p", "2p9s", "2p9u", "3dwl", "3dxk", "3dxm", "3rse", "3ukr", "3uku", "3ule", "4jd2", "4xei", "4xf2", "6dec", "6uhc", "6w17", "6w18", "6yw6", "6yw7", "7aqk", "7jpn", "7t5q", "7tpt", "8e9b", "8p94"...

40

[ "PUB00020552", "PUB00022758", "PUB00035127", "PUB00035128" ]

[ "9889097", "15505213", "9600938", "11752435" ]

[ "Scar1 and the related Wiskott-Aldrich syndrome protein, WASP, regulate the actin cytoskeleton through the Arp2/3 complex.", "Crystal structures of actin-related protein 2/3 complex with bound ATP or ADP.", "The interaction of Arp2/3 complex with actin: nucleation, high affinity pointed end capping, and formati...

[ 1998, 2004, 1998, 2001 ]

4

[]

0

null

[ "Bacteria", "Eukaryota" ]

[ 2, 5262 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 6, 2, 4, 1, 6, 6, 1, 4, 8, 1, 1, 5 ]

12

true

Family

Actin-related protein 2/3 complex subunit 5

ARPC5

3

IPR006790

6,790

Baculovirus Gp41, glycoprotein

Baculovirus_Gp41

Family

154

false

This is a family of viral structural glycoproteins [ ] from the baculoviridae.

[ "GO:0005198", "GO:0044423" ]

[ "structural molecule activity", "virion component" ]

[ "molecular_function", "cellular_component" ]

2

[ "PFAM" ]

[ "PF04700" ]

[ "Baculo_gp41" ]

[ 154 ]

1

[]

0

[]

0

[ "PUB00008560" ]

[ "1629955" ]

[ "Nucleotide sequence and transcriptional analysis of a gene encoding gp41, a structural glycoprotein of the baculovirus Autographa californica nuclear polyhedrosis virus." ]

[ 1992 ]

1

[]

0

null

[ "Baculoviridae" ]

[ 154 ]

1

[]

0

true

Family

Baculovirus Gp41, glycoprotein

Baculovirus_Gp41

2

IPR006791

6,791

Pox virus D2 protein

Pox_D2

Family

119

false

This entry represents the Pox virus D2 proteins, also known as OPG114. D2 is a late protein which is part of a large complex required for early virion morphogenesis. This complex participates in the formation of virosomes and the incorporation of virosomal contents into nascent immature virions [ ].

[]

0

[ "PFAM" ]

[ "PF04701" ]

[ "Pox_D2" ]

[ 119 ]

1

[]

0

[]

0

[ "PUB00078900" ]

[ "15567438" ]

[ "A complex of seven vaccinia virus proteins conserved in all chordopoxviruses is required for the association of membranes and viroplasm to form immature virions." ]

[ 2004 ]

1

[]

0

null

[ "Chordopoxvirinae" ]

[ 119 ]

1

[]

0

true

Family

Pox virus D2 protein

Pox_D2

7

IPR006792

6,792

Vicilin, N-terminal

Vicilin_N

Domain

203

false

This region is found in plant seed storage proteins, N-terminal to the Cupin domain ( ). In Macadamia integrifolia (Macadamia nut) ( ), this region is processed into peptides of approximately 50 amino acids containing a C-X-X-X-C-(10-12)X-C-X-X-X-C motif. These peptides exhibit antimicrobial activity in vitro [ ].

[]

0

[ "PFAM" ]

[ "PF04702" ]

[ "Vicilin_N" ]

[ 203 ]

1

[]

0

[ "6wql", "7lve", "7lvf" ]

3

[ "PUB00008561" ]

[ "10571855" ]

[ "A family of antimicrobial peptides is produced by processing of a 7S globulin protein in Macadamia integrifolia kernels." ]

[ 1999 ]

1

[]

0

null

[ "Eukaryota" ]

[ 203 ]

1

[]

0

true

Domain

Vicilin, N-terminal

Vicilin_N

8

IPR006793

6,793

FaeA-like protein

FaeA

Family

1,035

false

This family represents a number of fimbrial protein transcription regulators found in Gram-negative bacteria. These proteins are thought to facilitate binding of the leucine-rich regulatory protein to regulatory elements, possibly by inhibiting deoxyadenosine methylation of these elements by deoxyadenosine methylase [ ...

[ "GO:0006355" ]

[ "regulation of DNA-templated transcription" ]

[ "biological_process" ]

1

[ "PFAM" ]

[ "PF04703" ]

[ "FaeA" ]

[ 1035 ]

1

[]

0

[ "2htj", "2jt1" ]

2

[ "PUB00008562", "PUB00008563" ]

[ "7476191", "8846772" ]

[ "Negative control of fae (K88) expression by the 'global' regulator Lrp is modulated by the 'local' regulator FaeA and affected by DNA methylation.", "Differential binding of Lrp to two sets of pap DNA binding sites mediated by Pap I regulates Pap phase variation in Escherichia coli." ]

[ 1995, 1995 ]

2

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "ecological metagenomes", "uncultured Caudovirales phage" ]

[ 87, 929, 4, 14, 1 ]

5

[]

0

true

Family

FaeA-like protein

FaeA

8

IPR006794

6,794

Transcriptional activator, Zfx/Zfy domain

Transcrp_activ_Zfx/Zfy-dom

Domain

2,840

false

Zfx and Zfy are transcription factors implicated in mammalian sex determination. This region is found N-terminal to multiple copies of a C2H2 Zinc finger. This region has been shown to activate transcription when fused to a GAL4 DNA binding domain [ ].

[ "GO:0003677", "GO:0046872", "GO:0006355", "GO:0005634" ]

[ "DNA binding", "metal ion binding", "regulation of DNA-templated transcription", "nucleus" ]

[ "molecular_function", "molecular_function", "biological_process", "cellular_component" ]

4

[ "PFAM" ]

[ "PF04704" ]

[ "Zfx_Zfy_act" ]

[ 2840 ]

1

[ "REACTOME", "REACTOME" ]

[ "R-HSA-212436", "R-MMU-212436" ]

[ "REACTOME:R-HSA-212436", "REACTOME:R-MMU-212436" ]

2

[]

0

[ "PUB00008564" ]

[ "2105457" ]

[ "Mouse Zfx protein is similar to Zfy-2: each contains an acidic activating domain and 13 zinc fingers." ]

[ 1990 ]

1

[]

0

null

[ "Vertebrata" ]

[ 2840 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 7, 18, 13, 13 ]

4

true

Domain

Transcriptional activator, Zfx/Zfy domain

Transcrp_activ_Zfx/Zfy-dom

8

IPR006795

6,795

Thiostrepton-resistance methylase, N-terminal

Thiostrepton-R_Mease_TSNR_N

Domain

139

false

This region is found in some members of the SpoU-type rRNA methylase family ( ).

[ "GO:0008649", "GO:0046677" ]

[ "rRNA methyltransferase activity", "response to antibiotic" ]

[ "molecular_function", "biological_process" ]

2

[ "PFAM" ]

[ "PF04705" ]

[ "TSNR_N" ]

[ 139 ]

1

[ "EC" ]

[ "2.1.1.230" ]

[ "EC:2.1.1.230" ]

1

[ "3gyq", "3nk6", "3nk7" ]

3

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "hydrothermal vent metagenome" ]

[ 136, 2, 1 ]

3

[]

0

true

Domain

Thiostrepton-resistance methylase, N-terminal

Thiostrepton-R_Mease_TSNR_N

6

IPR006796

6,796

Dickkopf, N-terminal cysteine-rich

Dickkopf_N

Domain

3,282

false

Dickkopf proteins are a class of Wnt antagonists. They possess two conserved cysteine-rich regions. This entry represents the N-terminal conserved region [ ]. This domain, as its C-terminal region, have been found to share significant sequence similarity to the colipase fold ( ) [ ].

[ "GO:0007275", "GO:0030178", "GO:0005576" ]

[ "multicellular organism development", "negative regulation of Wnt signaling pathway", "extracellular region" ]

[ "biological_process", "biological_process", "cellular_component" ]

3

[ "PFAM" ]

[ "PF04706" ]

[ "Dickkopf_N" ]

[ 3282 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-201681", "R-HSA-3772470", "R-HSA-5339717", "R-MMU-3772470" ]

[ "REACTOME:R-HSA-201681", "REACTOME:R-HSA-3772470", "REACTOME:R-HSA-5339717", "REACTOME:R-MMU-3772470" ]

4

[ "5o57" ]

1

[ "PUB00008565", "PUB00008566" ]

[ "12167704", "9663378" ]

[ "Regulation of Wnt/LRP signaling by distinct domains of Dickkopf proteins.", "A colipase fold in the carboxy-terminal domain of the Wnt antagonists--the Dickkopfs." ]

[ 2002, 1998 ]

2

[]

[ "IPR047301", "IPR047303", "IPR047305" ]

0

3

0

[ "Eukaryota", "Pseudomonadati" ]

[ 3242, 40 ]

2

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 7, 17, 4, 11 ]

4

true

Domain

Dickkopf, N-terminal cysteine-rich

Dickkopf_N

6

IPR006798

6,798

Poxvirus F16

Poxvirus_F16

Family

136

false

This entry represents the Poxvirus F16 proteins, also known as Protein OPG061. This protein is expressed in the early phase of the viral replicative cycle [ , ].

[]

0

[ "PFAM", "PIRSF" ]

[ "PF04708", "PIRSF015792" ]

[ "Pox_F16", "VAC_F16L" ]

[ 136, 113 ]

2

[]

0

[]

0

[ "PUB00103587", "PUB00103588" ]

[ "21752417", "25903347" ]

[ "Vaccinia virus F16 protein, a predicted catalytically inactive member of the prokaryotic serine recombinase superfamily, is targeted to nucleoli.", "Deciphering poxvirus gene expression by RNA sequencing and ribosome profiling." ]

[ 2011, 2015 ]

2

[]

0

null

[ "Poxviridae" ]

[ 136 ]

1

[]

0

true

Family

Poxvirus F16

Poxvirus_F16

7

IPR006800

6,800

Pellino family

Pellino_fam

Family

4,117

false

Pellino proteins are E3 ubiquitin ligases that play an important role in immunity [ , ]. Pellinos contain a CHC2CHC2 RING E3 ubiquitin ligase domain [ ]. Mammalian Pellinos have been shown to mediate polyubiquitination of interleukin-1 receptor-associated kinase (IRAK) [ , ].

[ "GO:0061630", "GO:0000209", "GO:0008592" ]

[ "ubiquitin protein ligase activity", "protein polyubiquitination", "regulation of Toll signaling pathway" ]

[ "molecular_function", "biological_process", "biological_process" ]

3

[ "PIRSF", "PANTHER" ]

[ "PIRSF038886", "PTHR12098" ]

[ "Pellino", "" ]

[ 2810, 4117 ]

2

[ "EC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "2.3.2.27", "PWY-7511", "R-DME-9020702", "R-DME-937039", "R-DME-975144", "R-HSA-5675482", "R-HSA-9020702", "R-HSA-937039", "R-HSA-975144", "R-MMU-5675482", "R-MMU-9020702", "R-MMU-937039", "R-MMU-975144" ]

[ "EC:2.3.2.27", "METACYC:PWY-7511", "REACTOME:R-DME-9020702", "REACTOME:R-DME-937039", "REACTOME:R-DME-975144", "REACTOME:R-HSA-5675482", "REACTOME:R-HSA-9020702", "REACTOME:R-HSA-937039", "REACTOME:R-HSA-975144", "REACTOME:R-MMU-5675482", "REACTOME:R-MMU-9020702", "REACTOME:R-MMU-937039", "R...

13

[ "3ega", "3egb", "9if9" ]

3

[ "PUB00062960", "PUB00062961", "PUB00091671", "PUB00091674" ]

[ "16884718", "19022706", "26085209", "24445667" ]

[ "Pellino proteins are more than scaffold proteins in TLR/IL-1R signalling: a role as novel RING E3-ubiquitin-ligases.", "The Pellino family: IRAK E3 ligases with emerging roles in innate immune signalling.", "Molecular and physiological roles of Pellino E3 ubiquitin ligases in immunity.", "The roles of Pellin...

[ 2006, 2009, 2015, 2014 ]

4

[]

0

null

[ "Eukaryota" ]

[ 4117 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 13, 2, 13, 13, 14 ]

6

true

Family

Pellino family

Pellino_fam

8

IPR006801

6,801

Apolipoprotein A-II (ApoA-II)

ApoA-II

Family

466

false

Apolipoprotein A-II (ApoA-II) is the second major apolipoprotein of high density lipoprotein in human plasma. Mature ApoA-II is present as a dimer of two 77-amino acid chains joined by a disulphide bridge [ ]. ApoA-II regulates many steps in HDL metabolism, and its role in coronary heart disease is unclear [ ]. In bovi...

[ "GO:0008289", "GO:0006869", "GO:0042157", "GO:0005576" ]

[ "lipid binding", "lipid transport", "lipoprotein metabolic process", "extracellular region" ]

[ "molecular_function", "biological_process", "biological_process", "cellular_component" ]

4

[ "PFAM", "PANTHER" ]

[ "PF04711", "PTHR11027" ]

[ "ApoA-II", "" ]

[ 466, 262 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-381426", "R-BTA-8957275", "R-BTA-8963888", "R-BTA-8963901", "R-BTA-975634", "R-CFA-381426", "R-CFA-8957275", "R-CFA-8963888", "R-CFA-8963901", "R-CFA-975634", "R-HSA-1989781", "R-HSA-381426", "R-HSA-8957275", "R-HSA-8963888", "R-HSA-8963901", "R-HSA-975634", "R-MMU-381426", ...

[ "REACTOME:R-BTA-381426", "REACTOME:R-BTA-8957275", "REACTOME:R-BTA-8963888", "REACTOME:R-BTA-8963901", "REACTOME:R-BTA-975634", "REACTOME:R-CFA-381426", "REACTOME:R-CFA-8957275", "REACTOME:R-CFA-8963888", "REACTOME:R-CFA-8963901", "REACTOME:R-CFA-975634", "REACTOME:R-HSA-1989781", "REACTOME:R-...

26

[ "8oq4", "8oq5" ]

2

[ "PUB00008571", "PUB00009016" ]

[ "12119188", "9538260" ]

[ "Apolipoprotein A-II, HDL metabolism and atherosclerosis.", "Purification, primary structure, and antimicrobial activities of bovine apolipoprotein A-II." ]

[ 2002, 1998 ]

2

[]

0

null

[ "Arthrobacter globiformis", "Bilateria" ]

[ 1, 465 ]

2

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 7, 3, 4 ]

4

true

Family

Apolipoprotein A-II (ApoA-II)

ApoA-II

7

IPR006802

6,802

Radial spokehead-like protein

Radial_spoke

Family

3,472

false

This family includes the radial spoke head proteins RSP4 and RSP6 from Chlamydomonas reinhardtii, and several eukaryotic homologues, including mammalian RSHL1, the protein product of a familial ciliary dyskinesia candidate gene [ ]. The radial spoke head proteins are important in maintaining normal movement in motile, ...

[ "GO:0060271", "GO:0060294", "GO:0001534" ]

[ "cilium assembly", "cilium movement involved in cell motility", "radial spoke" ]

[ "biological_process", "biological_process", "cellular_component" ]

3

[ "PFAM", "PANTHER" ]

[ "PF04712", "PTHR13159" ]

[ "Radial_spoke", "" ]

[ 3472, 2691 ]

2

[]

0

[ "7dmp", "7jr9", "7jrj", "7jtk", "8glv", "8j07", "8wzb", "8x2u", "9e5c", "9fqr" ]

10

[ "PUB00008573", "PUB00092583", "PUB00092584" ]

[ "11237735", "19200523", "30185526" ]

[ "A mammalian radial spokehead-like gene, RSHL1, at the myotonic dystrophy-1 locus.", "Mutations in radial spoke head protein genes RSPH9 and RSPH4A cause primary ciliary dyskinesia with central-microtubular-pair abnormalities.", "RSPH6A is required for sperm flagellum formation and male fertility in mice." ]

[ 2001, 2009, 2018 ]

3

[]

0

null

[ "Eukaryota" ]

[ 3472 ]

1

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 3, 5, 6, 3, 6 ]

5

true

Family

Radial spokehead-like protein

Radial_spoke

8

IPR006803

6,803

Poxvirus I5

Poxvirus_I5

Family

109

false

This entry represents the Poxvirus protein I5, also known as Protein OPG081. In Vaccinia virus, I5 is associated with the membranous components of assembling and mature virions [ ].

[]

0

[ "PFAM", "PIRSF" ]

[ "PF04713", "PIRSF003768" ]

[ "Pox_I5", "VAC_I5L" ]

[ 109, 88 ]

2

[]

0

[]

0

[ "PUB00103589" ]

[ "19077320" ]

[ "Functional characterization of the vaccinia virus I5 protein." ]

[ 2008 ]

1

[]

0

null

[ "Bacteroidota", "Poxviridae" ]

[ 6, 103 ]

2

[]

0

true

Family

Poxvirus I5

Poxvirus_I5

2

IPR006804

6,804

BCL7

Family

3,220

false

The members of this group of sequences contain a conserved N-terminal domain which is found in the BCL7 family. Human BCL7 family consists of BCL7A, BCL7B, and BCL7C. They are involved in cancer incidence, progression, and development. BCL7B is commonly hemizygously deleted in patients with Williams syndrome [ ]. BCL7B...

[]

0

[ "PFAM", "PANTHER" ]

[ "PF04714", "PTHR12767" ]

[ "BCL_N", "" ]

[ 3006, 3152 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-9933937", "R-BTA-9933939", "R-BTA-9933946", "R-BTA-9933947", "R-BTA-9934037", "R-HSA-9824585", "R-HSA-9845323", "R-HSA-9933937", "R-HSA-9933939", "R-HSA-9933946", "R-HSA-9933947", "R-HSA-9934037", "R-MMU-9933937", "R-MMU-9933939", "R-MMU-9933946", "R-MMU-9933947", "R-MMU-99340...

[ "REACTOME:R-BTA-9933937", "REACTOME:R-BTA-9933939", "REACTOME:R-BTA-9933946", "REACTOME:R-BTA-9933947", "REACTOME:R-BTA-9934037", "REACTOME:R-HSA-9824585", "REACTOME:R-HSA-9845323", "REACTOME:R-HSA-9933937", "REACTOME:R-HSA-9933939", "REACTOME:R-HSA-9933946", "REACTOME:R-HSA-9933947", "REACTOM...

18

[]

0

[ "PUB00008574", "PUB00077969" ]

[ "9931421", "25569233" ]

[ "The BCL7 gene family: deletion of BCL7B in Williams syndrome.", "The Tumor Suppressor BCL7B Functions in the Wnt Signaling Pathway." ]

[ 1998, 2015 ]

2

[]

0

null

[ "Eukaryota" ]

[ 3220 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 7, 1, 8, 8, 15 ]

6

true

Family

BCL7

6

IPR006805

6,805

Anthranilate synthase component I, N-terminal

Anth_synth_I_N

Domain

40,291

false

Anthranilate synthase catalyses the first step in the biosynthesis of tryptophan. Component I catalyses the formation of anthranilate using ammonia and chorismate. The catalytic site lies in the adjacent region, described in the chorismate binding enzyme family ( ). This region is involved in feedback inhibition by try...

[ "GO:0009058" ]

[ "biosynthetic process" ]

[ "biological_process" ]

1

[ "PFAM" ]

[ "PF04715" ]

[ "Anth_synt_I_N" ]

[ 40291 ]

1

[ "EC", "METACYC", "METACYC" ]

[ "4.1.3.27", "PWY-5958", "PWY-6661" ]

[ "EC:4.1.3.27", "METACYC:PWY-5958", "METACYC:PWY-6661" ]

3

[ "1i1q", "1i7q", "1i7s", "1k0e", "1k0g", "1qdl", "4grh", "5cwa", "5kck", "7bvd", "7pi1", "7qu9", "8hx6", "8hx7", "8hx8", "8hx9", "8rp0", "8rp1", "8rp2", "8rp6" ]

20

[ "PUB00008575" ]

[ "11371633" ]

[ "The structures of anthranilate synthase of Serratia marcescens crystallized in the presence of (i) its substrates, chorismate and glutamine, and a product, glutamate, and (ii) its end-product inhibitor, L-tryptophan." ]

[ 2001 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Pandoravirus", "unclassified sequences" ]

[ 1080, 32563, 5991, 7, 650 ]

5

[ "Arabidopsis thaliana", "Escherichia coli (strain K12)", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)", "Zea mays" ]

[ 21, 2, 3, 11, 2, 2, 23 ]

7

true

Domain

Anthranilate synthase component I, N-terminal

Anth_synth_I_N

9

IPR006806

6,806

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5

NDUFA5

Family

4,576

false

NDUFA5, also known as NADH-ubiquinone oxidoreductase 13kDa-B subunit, is an accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) [ ].

[ "GO:0022904" ]

[ "respiratory electron transport chain" ]

[ "biological_process" ]

1

[ "PFAM", "PANTHER" ]

[ "PF04716", "PTHR12653" ]

[ "ETC_C1_NDUFA5", "" ]

[ 4327, 4484 ]

2

[ "GP", "GP", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "GenProp1230", "GenProp1637", "R-BTA-611105", "R-BTA-6799198", "R-BTA-9013408", "R-HSA-611105", "R-HSA-6799198", "R-HSA-9013408", "R-MMU-611105", "R-MMU-6799198", "R-MMU-9013408", "R-RNO-611105", "R-RNO-6799198", "R-RNO-9013408" ]

[ "GP:GenProp1230", "GP:GenProp1637", "REACTOME:R-BTA-611105", "REACTOME:R-BTA-6799198", "REACTOME:R-BTA-9013408", "REACTOME:R-HSA-611105", "REACTOME:R-HSA-6799198", "REACTOME:R-HSA-9013408", "REACTOME:R-MMU-611105", "REACTOME:R-MMU-6799198", "REACTOME:R-MMU-9013408", "REACTOME:R-RNO-611105", ...

14

[ "5gpn", "5gup", "5lc5", "5ldw", "5ldx", "5lnk", "5o31", "5xtb", "5xtd", "5xth", "5xti", "6g2j", "6g72", "6gcs", "6q9d", "6qa9", "6qbx", "6qc2", "6qc3", "6qc4", "6qc5", "6qc6", "6qc7", "6qc8", "6qc9", "6qca", "6qcf", "6rfq", "6rfr", "6rfs", "6x89", "6y79"...

266

[ "PUB00086570" ]

[ "27626371" ]

[ "Accessory subunits are integral for assembly and function of human mitochondrial complex I." ]

[ 2016 ]

1

[]

0

null

[ "Eukaryota" ]

[ 4576 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 10, 1, 1, 1, 9, 3, 1, 3, 5, 9 ]

10

true

Family

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5

NDUFA5

5

IPR006808

6,808

ATP synthase F0 complex subunit G, mitochondrial

ATP_synth_F0_gsu_mt

Family

5,798

false

This entry represents the G subunit found in the F0 complex of F-ATPases in mitochondria. The function of subunit G is currently unknown. There is no counterpart in chloroplast or bacterial F-ATPases identified so far [ ]. Transmembrane ATPases are membrane-bound enzyme complexes/ion transporters that use ATP hydrolysi...

[ "GO:0015078", "GO:0015986" ]

[ "proton transmembrane transporter activity", "proton motive force-driven ATP synthesis" ]

[ "molecular_function", "biological_process" ]

2

[ "PFAM", "PANTHER" ]

[ "PF04718", "PTHR12386" ]

[ "ATP-synt_G", "" ]

[ 5764, 4065 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-CEL-163210", "R-CEL-8949613", "R-CEL-9837999", "R-HSA-163210", "R-HSA-8949613", "R-HSA-9837999", "R-MMU-163210", "R-MMU-8949613", "R-MMU-9837999", "R-RNO-163210", "R-RNO-8949613", "R-RNO-9837999", "R-SCE-9837999" ]

[ "REACTOME:R-CEL-163210", "REACTOME:R-CEL-8949613", "REACTOME:R-CEL-9837999", "REACTOME:R-HSA-163210", "REACTOME:R-HSA-8949613", "REACTOME:R-HSA-9837999", "REACTOME:R-MMU-163210", "REACTOME:R-MMU-8949613", "REACTOME:R-MMU-9837999", "REACTOME:R-RNO-163210", "REACTOME:R-RNO-8949613", "REACTOME:R-...

13

[ "6tt7", "6za9", "6zbb", "6ziq", "6zit", "6ziu", "6zmr", "6zna", "6zpo", "6zqm", "6zqn", "7ajb", "7ajc", "7ajd", "7aje", "7ajf", "7ajg", "7ajh", "7aji", "7ajj", "8h9f", "8h9j", "8h9m", "8h9q", "8h9s", "8h9t", "8h9u", "8h9v", "8khf", "8ki3", "9b0x", "9b3j"...

35

[ "PUB00008578", "PUB00009752", "PUB00020603", "PUB00020604", "PUB00068786", "PUB00068787", "PUB00068788", "PUB00068789" ]

[ "8011660", "11309608", "15473999", "15078220", "20450191", "18937357", "1385979", "9741106" ]

[ "Fo membrane domain of ATP synthase from bovine heart mitochondria: purification, subunit composition, and reconstitution with F1-ATPase.", "Resolution of distinct rotational substeps by submillisecond kinetic analysis of F1-ATPase.", "The evolution of A-, F-, and V-type ATP synthases and ATPases: reversals in ...

[ 1994, 2001, 2004, 2004, 2010, 2008, 1992, 1998 ]

8

[]

[ "IPR016702" ]

0

1

0

[ "Eukaryota", "Gammaproteobacteria" ]

[ 5796, 2 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 9, 2, 1, 2, 6, 4, 1, 6, 5, 1, 1, 9 ]

12

true

Family

ATP synthase F0 complex subunit G, mitochondrial

ATP_synth_F0_gsu_mt

4

IPR006809

6,809

TAFII28-like protein domain

TAFII28_dom

Domain

4,511

false

The general transcription factor, TFIID, consists of the TATA-binding protein (TBP) associated with a series of TBP-associated factors (TAFs) that together participate in the assembly of the transcription preinitiation complex. This entry represents a conserved domain found at the C terminus of Transcription initiation...

[ "GO:0006367", "GO:0005634" ]

[ "transcription initiation at RNA polymerase II promoter", "nucleus" ]

[ "biological_process", "cellular_component" ]

2

[ "PFAM", "CDD" ]

[ "PF04719", "cd08048" ]

[ "TAFII28", "HFD_TAF11" ]

[ 4507, 4254 ]

2

[ "GP", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", ...

[ "GenProp2054", "R-DDI-674695", "R-DDI-6807505", "R-DDI-73776", "R-DDI-73779", "R-DDI-75953", "R-DDI-76042", "R-DME-674695", "R-DME-6804756", "R-DME-6807505", "R-DME-73776", "R-DME-73779", "R-DME-75953", "R-DME-76042", "R-HSA-167161", "R-HSA-167162", "R-HSA-167172", "R-HSA-674695", ...

[ "GP:GenProp2054", "REACTOME:R-DDI-674695", "REACTOME:R-DDI-6807505", "REACTOME:R-DDI-73776", "REACTOME:R-DDI-73779", "REACTOME:R-DDI-75953", "REACTOME:R-DDI-76042", "REACTOME:R-DME-674695", "REACTOME:R-DME-6804756", "REACTOME:R-DME-6807505", "REACTOME:R-DME-73776", "REACTOME:R-DME-73779", "R...

50

[ "1bh8", "1bh9", "6mzd", "6mzl", "7edx", "7eg7", "7eg8", "7eg9", "7ega", "7egb", "7egc", "7egd", "7ege", "7egf", "7egi", "7egj", "7ena", "7enc", "8gxq", "8gxs", "8wak", "8wal", "8wan", "8wao", "8wap", "8waq", "8war", "8was" ]

28

[ "PUB00006419", "PUB00008579", "PUB00014354", "PUB00101135", "PUB00101136" ]

[ "9695952", "7729427", "11963920", "15657423", "10744685" ]

[ "Human TAF(II)28 and TAF(II)18 interact through a histone fold encoded by atypical evolutionary conserved motifs also found in the SPT3 family.", "Cloning and characterization of hTAFII18, hTAFII20 and hTAFII28: three subunits of the human transcription factor TFIID.", "A unified nomenclature for TATA box bindi...

[ 1998, 1995, 2002, 2005, 2000 ]

5

[]

0

null

[ "Eukaryota" ]

[ 4511 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 6, 3, 3, 2, 16, 1, 1, 2, 5, 1, 1, 9 ]

12

true

Domain

TAFII28-like protein domain

TAFII28_dom

5

IPR006812

6,812

Glycine reductase complex selenoprotein A

GRDA

Family

1,058

false

Found in clostridia, this protein contains one active site selenocysteine and catalyses the reductive deamination of glycine, which is coupled to the esterification of orthophosphate resulting in the formation of ATP [ ]. A member of this family may also exist in Treponema denticola [ ].

[ "GO:0030699", "GO:0050485", "GO:0030700" ]

[ "glycine reductase activity", "oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with a disulfide as acceptor", "glycine reductase complex" ]

[ "molecular_function", "molecular_function", "cellular_component" ]

3

[ "HAMAP", "NCBIFAM", "PFAM", "PIRSF" ]

[ "MF_00826", "NF040748", "PF04723", "PIRSF000181" ]

[ "GRDA", "reduct_selen_A", "GRDA", "Grc_selenoprot_A" ]

[ 238, 703, 1058, 708 ]

4

[ "EC", "EC", "EC", "METACYC", "METACYC" ]

[ "1.21.4.2", "1.21.4.3", "1.21.4.4", "PWY-8015", "PWY-8303" ]

[ "EC:1.21.4.2", "EC:1.21.4.3", "EC:1.21.4.4", "METACYC:PWY-8015", "METACYC:PWY-8303" ]

5

[]

0

[ "PUB00008584", "PUB00008585" ]

[ "2963330", "11797052" ]

[ "Selenoprotein A of the clostridial glycine reductase complex: purification and amino acid sequence of the selenocysteine-containing peptide.", "Selenium-dependent growth of Treponema denticola: evidence for a clostridial-type glycine reductase." ]

[ 1988, 2001 ]

2

[]

0

null

[ "Bacteria", "metagenomes" ]

[ 1023, 35 ]

2

[]

0

true

Family

Glycine reductase complex selenoprotein A

GRDA

8

IPR006813

6,813

Glycosyl transferase, family 17

Glyco_trans_17

Family

6,165

false

This family represents beta-1,4-mannosyl-glycoprotein beta-1,4-N-acetylglucosaminyltransferase ( ). This enzyme transfers the bisecting GlcNAc to the core mannose of complex N-glycans. The addition of this residue is regulated during development and has functional consequences for receptor signalling, cell adhesion, an...

[ "GO:0003830", "GO:0016020" ]

[ "beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity", "membrane" ]

[ "molecular_function", "cellular_component" ]

2

[ "PFAM", "PANTHER" ]

[ "PF04724", "PTHR12224" ]

[ "Glyco_transf_17", "" ]

[ 5960, 6058 ]

2

[ "CAZY", "EC", "GP", "METACYC", "REACTOME", "REACTOME", "REACTOME" ]

[ "GT17", "2.4.1.144", "GenProp1524", "PWY-7426", "R-HSA-975574", "R-MMU-975574", "R-RNO-975574" ]

[ "CAZY:GT17", "EC:2.4.1.144", "GP:GenProp1524", "METACYC:PWY-7426", "REACTOME:R-HSA-975574", "REACTOME:R-MMU-975574", "REACTOME:R-RNO-975574" ]

7

[]

0

[ "PUB00008586", "PUB00008587" ]

[ "11986323", "11784313" ]

[ "Truncated, inactive N-acetylglucosaminyltransferase III (GlcNAc-TIII) induces neurological and other traits absent in mice that lack GlcNAc-TIII.", "A catalytically inactive beta 1,4-N-acetylglucosaminyltransferase III (GnT-III) behaves as a dominant negative GnT-III inhibitor." ]

[ 2002, 2002 ]

2

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "metagenomes" ]

[ 5, 350, 5716, 15, 79 ]

5

[ "Arabidopsis thaliana", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 25, 5, 1, 2, 2, 1, 11, 2, 18 ]

9

true

Family

Glycosyl transferase, family 17

Glyco_trans_17

3

IPR006814

6,814

Photosystem II PsbR

PSII_PsbR

Family

969

false

Oxygenic photosynthesis uses two multi-subunit photosystems (I and II) located in the cell membranes of cyanobacteria and in the thylakoid membranes of chloroplasts in plants and algae. Photosystem II (PSII) has a P680 reaction centre containing chlorophyll 'a' that uses light energy to carry out the oxidation (splitti...

[ "GO:0015979", "GO:0009523", "GO:0009654", "GO:0042651" ]

[ "photosynthesis", "photosystem II", "photosystem II oxygen evolving complex", "thylakoid membrane" ]

[ "biological_process", "cellular_component", "cellular_component", "cellular_component" ]

4

[ "PFAM", "PANTHER" ]

[ "PF04725", "PTHR34369" ]

[ "PsbR", "" ]

[ 966, 938 ]

2

[ "GP" ]

[ "GenProp0661" ]

[ "GP:GenProp0661" ]

1

[ "8bd3", "8z9d", "9hd7" ]

3

[ "PUB00015357", "PUB00015358", "PUB00015359", "PUB00015373", "PUB00097583", "PUB00152828" ]

[ "12518057", "15100025", "14871485", "1697267", "30076221", "33846594" ]

[ "Crystal structure of oxygen-evolving photosystem II from Thermosynechococcus vulcanus at 3.7-A resolution.", "The evolutionary development of the protein complement of photosystem 2.", "The low molecular mass subunits of the photosynthetic supracomplex, photosystem II.", "Anti-sense RNA efficiently inhibits ...

[ 2003, 2004, 2004, 1990, 2018, 2021 ]

6

[]

0

null

[ "Bacteria", "Eukaryota" ]

[ 11, 958 ]

2

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 6, 9, 3 ]

3

true

Family

Photosystem II PsbR

PSII_PsbR

9

IPR006815

6,815

Microvirus J protein-like

Microvir_J-like

Family

169

false

This entry represents the Microvirus J protein and related proteins from bacteria.

[ "GO:0003677" ]

[ "DNA binding" ]

[ "molecular_function" ]

1

[ "PFAM", "PIRSF" ]

[ "PF04726", "PIRSF004161" ]

[ "Microvir_J", "Microvir_J" ]

[ 169, 35 ]

2

[]

0

[ "1gff", "1m06", "1rb8", "2bpa", "9k3m", "9k3n" ]

6

[ "PUB00008589" ]

[ "911774" ]

[ "Amino acid sequence of the small core protein from bacteriophage phiX174." ]

[ 1977 ]

1

[]

0

null

[ "Bacteria", "Bullavirinae", "Candidatus Argoarchaeum ethanivorans", "Opisthokonta" ]

[ 88, 68, 1, 12 ]

4

[]

0

true

Family

Microvirus J protein-like

Microvir_J-like

7

IPR006816

6,816

ELMO domain

ELMO_dom

Domain

16,426

false

This entry represents the ELMO (EnguLfment and Cell MOtility) domain, which is found in a number of eukaryotic proteins involved in the cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility, including CED-12, ELMO-1 and ELMO-2.

[]

0

[ "PFAM", "PROFILE" ]

[ "PF04727", "PS51335" ]

[ "ELMO_CED12", "ELMO" ]

[ 16394, 15974 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-CEL-8849471", "R-CEL-9013408", "R-DDI-8849471", "R-DDI-9013408", "R-HSA-164944", "R-HSA-2029482", "R-HSA-4420097", "R-HSA-8849471", "R-HSA-9013408", "R-HSA-9664422", "R-MMU-2029482", "R-MMU-4420097", "R-MMU-8849471", "R-MMU-9013408" ]

[ "REACTOME:R-CEL-8849471", "REACTOME:R-CEL-9013408", "REACTOME:R-DDI-8849471", "REACTOME:R-DDI-9013408", "REACTOME:R-HSA-164944", "REACTOME:R-HSA-2029482", "REACTOME:R-HSA-4420097", "REACTOME:R-HSA-8849471", "REACTOME:R-HSA-9013408", "REACTOME:R-HSA-9664422", "REACTOME:R-MMU-2029482", "REACTOME...

14

[ "6idx", "6ie1", "6tgb", "6tgc", "7dpa", "8jhk", "8xm7", "8zj2", "8zji", "8zjj", "8zjk", "8zjl", "8zjm" ]

13

[ "PUB00043715" ]

[ "17452337" ]

[ "ELMOD2 is an Arl2 GTPase-activating protein that also acts on Arfs." ]

[ 2007 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "uncultured organism MedDCM-OCT-S01-C25" ]

[ 3, 16422, 1 ]

3

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 33, 4, 26, 3, 24, 20, 1, 25, 24, 80 ]

10

true

Domain

ELMO domain

ELMO_dom

1

IPR006817

6,817

Lipoprotein leucine-zipper

Lipoprotein_leucine-zipper_dom

Domain

2,316

false

This is leucine-zipper is found in the enterobacterial outer membrane lipoprotein LPP [ ]. It is likely that this domain oligomerises and is involved in protein-protein interactions. As such it is a bundle of α-helical coiled-coils, which are known to play key roles in mediating specific protein-protein interactions fo...

[ "GO:0019867" ]

[ "outer membrane" ]

[ "cellular_component" ]

1

[ "PFAM" ]

[ "PF04728" ]

[ "LPP" ]

[ 2316 ]

1

[]

0

[ "1eq7", "1jcc", "1jcd", "1kfm", "1kfn", "1t8z", "2gus", "2guv" ]

8

[ "PUB00028451", "PUB00028826", "PUB00031380", "PUB00041187" ]

[ "10843861", "12054830", "15520380", "16828114" ]

[ "Core structure of the outer membrane lipoprotein from Escherichia coli at 1.9 A resolution.", "Core side-chain packing and backbone conformation in Lpp-56 coiled-coil mutants.", "Atomic structure of a tryptophan-zipper pentamer.", "Conformational transition between four and five-stranded phenylalanine zipper...

[ 2000, 2002, 2004, 2006 ]

4

[]

0

null

[ "Bacteria", "Fungi", "Seunavirus", "human gut metagenome" ]

[ 2299, 14, 2, 1 ]

4

[ "Escherichia coli (strain K12)" ]

[ 2 ]

1

true

Domain

Lipoprotein leucine-zipper

Lipoprotein_leucine-zipper_dom

6

IPR006818

6,818

Histone chaperone ASF1-like

ASF1-like

Family

6,241

false

This family includes the yeast and human ASF1 protein. These proteins have histone chaperone activity [ ]. ASF1 participates in both the replication-dependent and replication-independent pathways. The structure three-dimensional has been determined as a compact immunoglobulin-like β-sandwich fold topped by three helica...

[ "GO:0006325", "GO:0005634" ]

[ "chromatin organization", "nucleus" ]

[ "biological_process", "cellular_component" ]

2

[ "PFAM", "PANTHER" ]

[ "PF04729", "PTHR12040" ]

[ "ASF1_hist_chap", "" ]

[ 6237, 6105 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-2559584", "R-CEL-2559584", "R-GGA-2559584", "R-HSA-2559584", "R-MMU-2559584", "R-SCE-2559584" ]

[ "REACTOME:R-BTA-2559584", "REACTOME:R-CEL-2559584", "REACTOME:R-GGA-2559584", "REACTOME:R-HSA-2559584", "REACTOME:R-MMU-2559584", "REACTOME:R-SCE-2559584" ]

6

[ "1roc", "1tey", "1wg3", "2cu9", "2dze", "2hue", "2i32", "2idc", "2iij", "2io5", "2ygv", "2z34", "2z3f", "3aad", "4eo5", "4rrp", "4zbj", "5bnx", "5bo0", "5c3i", "5eii", "5ucb", "5uea", "5uek", "5zba", "5zbb", "6a6y", "6ayz", "6az2", "6f0f", "6f0g", "6f0h"...

53

[ "PUB00008590", "PUB00019146" ]

[ "10759893", "14680630" ]

[ "A human homologue of yeast anti-silencing factor has histone chaperone activity.", "Structure and function of the conserved core of histone deposition protein Asf1." ]

[ 2000, 2003 ]

2

[]

[ "IPR017282" ]

0

1

0

[ "Eukaryota" ]

[ 6241 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 5, 2, 2, 2, 7, 4, 1, 7, 5, 1, 1, 7 ]

12

true

Family

Histone chaperone ASF1-like

ASF1-like

6

IPR006819

6,819

Agrobacterium VirD5 protein

Agro_VirD5

Family

93

false

The virD operon in Agrobacterium encodes a site-specific endonuclease, and a number of other poorly characterised products [ ]. This family represents the VirD5 protein.

[]

0

[ "PFAM", "PIRSF", "SMART" ]

[ "PF04730", "PIRSF035823", "SM00795" ]

[ "Agro_virD5", "Agro_virD5", "Agro_virD5" ]

[ 93, 47, 60 ]

3

[]

0

[]

0

[ "PUB00019114" ]

[ "3658701" ]

[ "Molecular characterization of the virD operon from Agrobacterium tumefaciens." ]

[ 1987 ]

1

[]

0

null

[ "Bacteria", "Bdelloidea", "Plasmid Ti" ]

[ 80, 12, 1 ]

3

[]

0

true

Family

Agrobacterium VirD5 protein

Agro_VirD5

7

IPR006820

6,820

Caudal-like activation domain

Caudal_activation_dom

Domain

2,503

false

This domain occurs at the N-terminal of proteins belonging to the caudal-related homeobox protein family. This region is thought to mediate transcription activation. The level of activation caused by mouse Cdx2 ( ) is affected by phosphorylation at serine 60 via the mitogen-activated protein kinase pathway [ ]. Caudal ...

[ "GO:0006355", "GO:0007275", "GO:0005634" ]

[ "regulation of DNA-templated transcription", "multicellular organism development", "nucleus" ]

[ "biological_process", "biological_process", "cellular_component" ]

3

[ "PFAM" ]

[ "PF04731" ]

[ "Caudal_act" ]

[ 2503 ]

1

[ "REACTOME" ]

[ "R-HSA-381771" ]

[ "REACTOME:R-HSA-381771" ]

1

[]

0

[ "PUB00008591" ]

[ "11729123" ]

[ "Phosphorylation of the serine 60 residue within the Cdx2 activation domain mediates its transactivation capacity." ]

[ 2001 ]

1

[]

0

null

[ "Deuterostomia" ]

[ 2503 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 3, 5, 6, 6 ]

4

true

Domain

Caudal-like activation domain

Caudal_activation_dom

8

IPR006822

6,822

Coatomer, epsilon subunit

Coatomer_esu

Family

5,497

false

This entry represents the epsilon subunit of the coatomer complex, which is involved in the regulation of intracellular protein trafficking between the endoplasmic reticulum and the Golgi complex [ ]. Proteins synthesised on the ribosome and processed in the endoplasmic reticulum are transported from the Golgi apparatu...

[ "GO:0005198", "GO:0006890" ]

[ "structural molecule activity", "retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum" ]

[ "molecular_function", "biological_process" ]

2

[ "PFAM", "PIRSF", "PANTHER" ]

[ "PF04733", "PIRSF016478", "PTHR10805" ]

[ "Coatomer_E", "Coatomer_esu", "" ]

[ 5495, 3961, 5043 ]

3

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-6807878", "R-BTA-6811434", "R-CEL-6807878", "R-CEL-6811434", "R-DDI-6807878", "R-DDI-6811434", "R-GGA-6807878", "R-GGA-6811434", "R-HSA-6807878", "R-HSA-6811434", "R-MMU-6807878", "R-MMU-6811434", "R-SCE-6807878", "R-SCE-6811434", "R-SPO-6807878", "R-SPO-6811434" ]

[ "REACTOME:R-BTA-6807878", "REACTOME:R-BTA-6811434", "REACTOME:R-CEL-6807878", "REACTOME:R-CEL-6811434", "REACTOME:R-DDI-6807878", "REACTOME:R-DDI-6811434", "REACTOME:R-GGA-6807878", "REACTOME:R-GGA-6811434", "REACTOME:R-HSA-6807878", "REACTOME:R-HSA-6811434", "REACTOME:R-MMU-6807878", "REACTOM...

16

[ "3mkr", "3mv2", "3mv3", "5a1v", "5a1y", "5nzt", "5nzv", "6tzt", "6u3v", "6u3w" ]

10

[ "PUB00008596", "PUB00030524", "PUB00035767", "PUB00035768", "PUB00035769", "PUB00100149", "PUB00103198" ]

[ "10469566", "14690497", "11208122", "17041781", "15261670", "26160949", "28621666" ]

[ "Segregation of COPI-rich and anterograde-cargo-rich domains in endoplasmic-reticulum-to-Golgi transport complexes.", "Gamma-COP appendage domain - structure and function.", "Traffic COPs of the early secretory pathway.", "COPI-mediated transport.", "COP and clathrin-coated vesicle budding: different pathwa...

[ 1999, 2004, 2000, 2006, 2004, 2015, 2017 ]

7

[]

0

null

[ "Bacteria", "Eukaryota", "Methanobacteriati", "ecological metagenomes" ]

[ 193, 5296, 2, 6 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 6, 1, 1, 1, 5, 6, 1, 2, 9, 1, 1, 53 ]

12

true

Family

Coatomer, epsilon subunit

Coatomer_esu

4

IPR006824

6,824

DNA helicase, Baculovirus

DNA_helicase_Baculovir

Family

199

false

Baculovirus P143 is a DNA helicase essential for virus DNA replication [ , ]. It has distinct roles during infection and contributes to host range determination [ , ].

[ "GO:0003678", "GO:0019079" ]

[ "DNA helicase activity", "viral genome replication" ]

[ "molecular_function", "biological_process" ]

2

[ "PFAM" ]

[ "PF04735" ]

[ "Baculo_helicase" ]

[ 199 ]

1

[]

0

[]

0

[ "PUB00081465", "PUB00081470", "PUB00081471", "PUB00081472" ]

[ "10799604", "7972036", "23784443", "26313611" ]

[ "The Autographa californica nuclear polyhedrosis virus p143 gene encodes a DNA helicase.", "Identification of genes involved in DNA replication of the Autographa californica baculovirus.", "Degradation of rRNA in BM-N cells from the silkworm Bombyx mori during abortive infection with heterologous nucleopolyhedr...

[ 2000, 1994, 2013, 2015 ]

4

[]

0

null

[ "Baculoviridae" ]

[ 199 ]

1

[]

0

true

Family

DNA helicase, Baculovirus

DNA_helicase_Baculovir

7

IPR006825

6,825

Eclosion hormone

Eclosion

Family

450

false

Eclosion hormone is an insect neuropeptide that triggers the performance of ecdysis behaviour, which causes shedding of the old cuticle at the end of a molt [ , ].

[ "GO:0008255", "GO:0007218", "GO:0018990" ]

[ "ecdysis-triggering hormone activity", "neuropeptide signaling pathway", "ecdysis, chitin-based cuticle" ]

[ "molecular_function", "biological_process", "biological_process" ]

3

[ "PFAM", "PIRSF" ]

[ "PF04736", "PIRSF001859" ]

[ "Eclosion", "Eclosion" ]

[ 450, 160 ]

2

[]

0

[]

0

[ "PUB00008597", "PUB00008598" ]

[ "11950244", "1634328" ]

[ "Integration of endocrine signals that regulate insect ecdysis.", "Complete structure of eclosion hormone of Manduca sexta. Assignment of disulfide bond location." ]

[ 2002, 1992 ]

2

[]

0

null

[ "Protostomia" ]

[ 450 ]

1

[ "Drosophila melanogaster" ]

[ 2 ]

1

true

Family

Eclosion hormone

Eclosion

8

IPR006827

6,827

Lantibiotic dehydratase, N-terminal

Lant_deHydtase_N

Domain

4,979

false

Lantibiotics are ribosomally synthesised antimicrobial agents derived from ribosomally synthesised peptides [ ]. They are produced by bacteria of the Firmicutes phylum, and include mutacin, subtilin, and nisin. Lantibiotic peptides contain thioether bridges termed lanthionines that are thought to be generated by dehydr...

[]

0

[ "PFAM" ]

[ "PF04738" ]

[ "Lant_dehydr_N" ]

[ 4979 ]

1

[ "GP" ]

[ "GenProp1069" ]

[ "GP:GenProp1069" ]

1

[ "4wd9", "5ehk", "6ec7", "6ec8", "6m7y", "9g04", "9g05" ]

7

[ "PUB00008599", "PUB00008600", "PUB00009021", "PUB00086838" ]

[ "1539969", "12127987", "10215865", "25363770" ]

[ "Analysis of genes involved in biosynthesis of the lantibiotic subtilin.", "Heterologous expression and purification of SpaB involved in subtilin biosynthesis.", "Post-translational modification of nisin. The involvement of NisB in the dehydration process.", "Structure and mechanism of the tRNA-dependent lant...

[ 1992, 2002, 1999, 2015 ]

4

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 4974, 2, 3 ]

3

[]

0

true

Domain

Lantibiotic dehydratase, N-terminal

Lant_deHydtase_N

2

IPR006828

6,828

Association with the SNF1 complex (ASC) domain

ASC_dom

Domain

7,862

false

Association with the SNF1 complex (ASC) domain is found in the Sip1/Sip2/Gal83/AMPKbeta subunits of the SNF1/AMP-activated protein kinase (AMPK) complex [ ]. SNF1/AMPK are heterotrimeric enzymes composed of a catalytic alpha-subunit, a regulatory gamma-subunit and a regulatory/targeting beta-subunit [ ]. Saccharomyces ...

[ "GO:0005515" ]

[ "protein binding" ]

[ "molecular_function" ]

1

[ "PFAM", "SMART" ]

[ "PF04739", "SM01010" ]

[ "AMPKBI", "AMPKBI" ]

[ 7837, 7822 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-1632852", "R-BTA-380972", "R-BTA-5628897", "R-BTA-6804756", "R-HSA-1445148", "R-HSA-1632852", "R-HSA-163680", "R-HSA-200425", "R-HSA-2151209", "R-HSA-380972", "R-HSA-5628897", "R-HSA-6804756", "R-HSA-9613354", "R-HSA-9619483", "R-MMU-1632852", "R-MMU-163680", "R-MMU-200425", ...

[ "REACTOME:R-BTA-1632852", "REACTOME:R-BTA-380972", "REACTOME:R-BTA-5628897", "REACTOME:R-BTA-6804756", "REACTOME:R-HSA-1445148", "REACTOME:R-HSA-1632852", "REACTOME:R-HSA-163680", "REACTOME:R-HSA-200425", "REACTOME:R-HSA-2151209", "REACTOME:R-HSA-380972", "REACTOME:R-HSA-5628897", "REACTOME:R-...

35

[ "2oox", "2ooy", "2qlv", "2qr1", "2qrc", "2qrd", "2qre", "2v8q", "2v92", "2v9j", "2y8l", "2y8q", "2ya3", "3t4n", "3tdh", "3te5", "4cfe", "4cff", "4cfh", "4eag", "4eai", "4eaj", "4eak", "4eal", "4qfg", "4qfr", "4qfs", "4rer", "4rew", "4zhx", "5ezv", "5iso"...

50

[ "PUB00008604", "PUB00042779", "PUB00071595", "PUB00071596", "PUB00071601", "PUB00072630" ]

[ "7813428", "17981722", "10207618", "10990457", "9121458", "11252725" ]

[ "A family of proteins containing a conserved domain that mediates interaction with the yeast SNF1 protein kinase complex.", "SNF1/AMPK pathways in yeast.", "Roles of the AMP-activated/SNF1 protein kinase family in the response to cellular stress.", "beta-subunits of Snf1 kinase are required for kinase functio...

[ 1994, 2008, 1999, 2000, 1997, 2001 ]

6

[]

0

null

[ "Eukaryota" ]

[ 7862 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 12, 2, 6, 3, 7, 5, 1, 13, 6, 3, 1, 21 ]

12

true

Domain

Association with the SNF1 complex (ASC) domain

ASC_dom

2

IPR006829

6,829

LXG domain

LXG_dom

Domain

3,526

false

This domain is present at the N-terminal region of a group of polymorphic toxin proteins in bacteria [ ]. LXG toxins mediate intraspecies competition in biofilms and may also help to avoid warfare between strains in biofilms [ ].

[]

0

[ "PFAM", "PROFILE" ]

[ "PF04740", "PS51756" ]

[ "LXG", "LXG" ]

[ 3038, 3289 ]

2

[]

0

[ "8gmh" ]

1

[ "PUB00057479", "PUB00101092" ]

[ "21306995", "34280190" ]

[ "A novel immunity system for bacterial nucleic acid degrading toxins and its recruitment in various eukaryotic and DNA viral systems.", "Diverse LXG toxin and antitoxin systems specifically mediate intraspecies competition in Bacillus subtilis biofilms." ]

[ 2011, 2021 ]

2

[]

0

null

[ "Bacillus phage SPbeta", "Bacteria", "Eukaryota" ]

[ 1, 3520, 5 ]

3

[]

0

true

Domain

LXG domain

LXG_dom

3

IPR006830

6,830

InvH outer membrane lipoprotein

InvH

Family

489

false

This family of proteins includes SPI-1 type 3 secretion system pilotin (also known as outer membrane lipoprotein InvH) from Salmonella, which is required for the localisation to outer membrane of InvG, which is involved in a type III secretion apparatus mediating host cell invasion [ , ].

[]

0

[ "PFAM" ]

[ "PF04741" ]

[ "InvH" ]

[ 489 ]

1

[]

0

[ "6xfj", "6xfk", "6xfl" ]

3

[ "PUB00008605", "PUB00008606" ]

[ "9680224", "9786184" ]

[ "The Salmonella typhimurium InvH protein is an outer membrane lipoprotein required for the proper localization of InvG.", "Salmonella InvG forms a ring-like multimer that requires the InvH lipoprotein for outer membrane localization." ]

[ 1998, 1998 ]

2

[]

0

null

[ "Gammaproteobacteria" ]

[ 489 ]

1

[]

0

true

Family

InvH outer membrane lipoprotein

InvH

7

IPR006833

6,833

Ammonia monooxygenase/particulate methane monooxygenase, subunit B

NH3_CH4_mOase_B

Family

389

false

Ammonia monooxygenase and the particulate methane monooxygenase are both integral membrane proteins, occurring in ammonia oxidisers and methanotrophs respectively, which are thought to be evolutionarily related [ ]. These enzymes have a relatively wide substrate specificity and can catalyse the oxidation of a range of ...

[]

0

[ "PFAM", "NCBIFAM" ]

[ "PF04744", "TIGR03079" ]

[ "Monooxygenase_B", "CH4_NH3mon_ox_B" ]

[ 389, 179 ]

2

[ "GP" ]

[ "GenProp0666" ]

[ "GP:GenProp0666" ]

1

[ "1yew", "3chx", "3rfr", "3rgb", "4o65", "4phz", "4pi0", "4pi2", "6cxh", "7ev9", "7s4h", "7s4i", "7s4j", "7s4k", "7s4l", "7s4m", "7t4o", "7t4p", "7yzy", "8oyi", "8sqw", "8sr1", "8sr2", "8sr4", "8sr5", "9cl1", "9cl2", "9cl3", "9cl4", "9cl5", "9cl6" ]

31

[ "PUB00016963", "PUB00016964", "PUB00016965" ]

[ "7590173", "12209257", "15674245" ]

[ "Evidence that particulate methane monooxygenase and ammonia monooxygenase may be evolutionarily related.", "Molecular biology and biochemistry of ammonia oxidation by Nitrosomonas europaea.", "Crystal structure of a membrane-bound metalloenzyme that catalyses the biological oxidation of methane." ]

[ 1995, 2002, 2005 ]

3

[]

0

null

[ "Archaea", "Bacteria", "unclassified sequences" ]

[ 89, 287, 13 ]

3

[]

0

true

Family

Ammonia monooxygenase/particulate methane monooxygenase, subunit B

NH3_CH4_mOase_B

7

IPR006834

6,834

VITF-3 subunit protein

Pox_A8

Family

120

false

This is a family of Chordopoxvirus proteins composing one of the two subunits that make up VITF-3, a virally encoded complex necessary for intermediate stage transcription [ ].

[]

0

[ "PFAM" ]

[ "PF04745" ]

[ "Pox_A8" ]

[ 120 ]

1

[]

0

[ "8p0j", "8p0k", "8p0n" ]

3

[ "PUB00008609" ]

[ "10077573" ]

[ "Identification of a transcription factor, encoded by two vaccinia virus early genes, that regulates the intermediate stage of viral gene expression." ]

[ 1999 ]

1

[]

0

null

[ "Bernardetia litoralis (strain ATCC 23117 / DSM 6794 / NBRC 15988 / NCIMB 1366 / Fx l1 / Sio-4)", "Poxviridae" ]

[ 1, 119 ]

2

[]

0

true

Family

VITF-3 subunit protein

Pox_A8

6

IPR006835

6,835

Domain of unknown function DUF575

DUF575

Domain

28

false

This represents a conserved region found in a number of Chlamydophila pneumoniae proteins.

[]

0

[ "PFAM" ]

[ "PF04746" ]

[ "DUF575" ]

[ 28 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Chlamydia" ]

[ 28 ]

1

[]

0

true

Domain

Domain of unknown function DUF575

DUF575

4

IPR006836

6,836

Protein of unknown function DUF612

DUF612

Family

60

false

This family includes several uncharacterised proteins from Caenorhabditis elegans.

[]

0

[ "PFAM" ]

[ "PF04747" ]

[ "DUF612" ]

[ 60 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Rhabditomorpha" ]

[ 60 ]

1

[ "Caenorhabditis elegans" ]

[ 23 ]

1

true

Family

Protein of unknown function DUF612

DUF612

8

IPR006837

6,837

Divergent polysaccharide deacetylase

Divergent_DAC

Family

7,387

false

This family contains an uncharacterised protein from Bacillus halodurans, an uncharacterised protein from Agrobacterium tumefaciens C58, and other bacterial hypothetical proteins. Although their functions are still unknown, structural superposition and sequence comparison suggest that BH1492 and ATU2773 might be diverg...

[]

0

[ "PFAM", "PANTHER", "CDD" ]

[ "PF04748", "PTHR30105", "cd10936" ]

[ "Polysacc_deac_2", "", "CE4_DAC2" ]

[ 7381, 6808, 7125 ]

3

[]

0

[ "2nly", "2qv5" ]

2

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences", "uncultured marine group III euryarchaeote KM3-28-E8" ]

[ 7230, 12, 144, 1 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Divergent polysaccharide deacetylase

Divergent_DAC

6

IPR006838

6,838

ADTRP/AIG1

ADTRP_AIG1

Family

6,574

false

This family includes the androgen-dependent TFPI-regulating protein (ADTRP) and AIG1 protein which were first described as the homologues of hamster androgen-induced FAR-17a protein [ , ]. AIG1 and ADTRP hydrolyzes bioactive fatty-acid esters of hydroxy-fatty acids (FAHFAs), but not other major classes of lipids, with ...

[ "GO:0016020" ]

[ "membrane" ]

[ "cellular_component" ]

1

[ "PFAM", "PANTHER" ]

[ "PF04750", "PTHR10989" ]

[ "Far-17a_AIG1", "" ]

[ 6545, 5791 ]

2

[]

0

[]

0

[ "PUB00008610", "PUB00008611", "PUB00101589", "PUB00101590" ]

[ "2045681", "11266118", "27018888", "21868574" ]

[ "Isolation and characterization of cDNA for an androgen-regulated mRNA in the flank organ of hamsters.", "Cloning of androgen-inducible gene 1 (AIG1) from human dermal papilla cells.", "AIG1 and ADTRP are atypical integral membrane hydrolases that degrade bioactive FAHFAs.", "Novel protein ADTRP regulates TFP...

[ 1991, 2001, 2016, 2011 ]

4

[]

0

null

[ "Bacteria", "Eukaryota", "marine metagenome", "unclassified Candidatus Thermoprofundales" ]

[ 70, 6496, 2, 6 ]

4

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strai...

[ 5, 10, 10, 13, 9, 1, 8, 1, 1 ]

9

true

Family

ADTRP/AIG1

ADTRP_AIG1

9

IPR006839

6,839

Dual-action ribosomal maturation protein DarP

DarP

Family

6,902

false

The entry represents the Dual-action ribosomal maturation protein DarP (also known as YjgA) from Escherichia coli and related proteins. This protein binds pre-50S ribosomal subunits near the 23S rRNA L1 stalk, where it may mediate correct positioning of the L1 stalk [ ]. It plays a dual role in the late stages of assem...

[]

0

[ "HAMAP", "NCBIFAM", "PFAM", "PIRSF", "PANTHER", "CDD" ]

[ "MF_00765", "NF003593", "PF04751", "PIRSF016183", "PTHR38101", "cd16331" ]

[ "DarP", "PRK05255.1-1", "DarP", "UCP016183", "", "YjgA-like" ]

[ 5656, 6154, 6897, 5653, 6215, 6668 ]

6

[]

0

[ "2p0t", "7bl5", "9h3q", "9h3r", "9h3s" ]

5

[ "PUB00045877", "PUB00104166", "PUB00155442" ]

[ "16980477", "33639093", "38842932" ]

[ "The Escherichia coli GTPase CgtAE is involved in late steps of large ribosome assembly.", "Snapshots of native pre-50S ribosomes reveal a biogenesis factor network and evolutionary specialization.", "YjgA plays dual roles in enhancing PTC maturation." ]

[ 2006, 2021, 2024 ]

3

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 6151, 690, 61 ]

3

[ "Arabidopsis thaliana", "Escherichia coli (strain K12)", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 4, 1, 3, 3 ]

4

true

Family

Dual-action ribosomal maturation protein DarP

DarP

5

IPR006840

6,840

Glutathione-specific gamma-glutamylcyclotransferase

ChaC

Family

12,845

false

The ChaC family of proteins function as gamma-glutamyl cyclotransferases acting specifically to degrade glutathione but not other gamma-glutamyl peptides [ , ]. It is is conversed across all phyla and represents a new pathway for glutathione degradation in living cells.

[ "GO:0061928", "GO:0006751" ]

[ "glutathione specific gamma-glutamylcyclotransferase activity", "glutathione catabolic process" ]

[ "molecular_function", "biological_process" ]

2

[ "PFAM", "PANTHER" ]

[ "PF04752", "PTHR12192" ]

[ "ChaC", "" ]

[ 12843, 12433 ]

2

[ "EC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "4.3.2.7", "PWY-7942", "R-BTA-174403", "R-DRE-174403", "R-HSA-174403", "R-HSA-9648895", "R-MMU-174403", "R-RNO-174403", "R-SCE-174403", "R-SPO-174403" ]

[ "EC:4.3.2.7", "METACYC:PWY-7942", "REACTOME:R-BTA-174403", "REACTOME:R-DRE-174403", "REACTOME:R-HSA-174403", "REACTOME:R-HSA-9648895", "REACTOME:R-MMU-174403", "REACTOME:R-RNO-174403", "REACTOME:R-SCE-174403", "REACTOME:R-SPO-174403" ]

10

[ "5hwi", "5hwk", "6k95", "6ky0", "6ky1" ]

5

[ "PUB00080684", "PUB00080685" ]

[ "23070364", "25716890" ]

[ "Mammalian proapoptotic factor ChaC1 and its homologues function as γ-glutamyl cyclotransferases acting specifically on glutathione.", "Defining the cytosolic pathway of glutathione degradation in Arabidopsis thaliana: role of the ChaC/GCG family of γ-glutamyl cyclotransferases as glutathione-degrading enzymes an...

[ 2012, 2015 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 6092, 6689, 64 ]

3

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus",...

[ 13, 3, 3, 2, 1, 2, 2, 1, 6, 6, 1, 1, 59 ]

13

true

Family

Glutathione-specific gamma-glutamylcyclotransferase

ChaC

4

IPR006841

6,841

Coronavirus nonstructural protein NS2

Corona_NS2

Family

129

false

This is a family of Coronavirus nonstructural protein NS2. Phosphoamino acid analysis confirmed the phosphorylated nature of NS2 and identified serine and threonine as its phosphorylated amino acid residues [ ]. It was also demonstrated that the ns2 gene product is not essential for Murine hepatitis virus replication i...

[]

0

[ "PFAM" ]

[ "PF04753" ]

[ "Corona_NS12-7" ]

[ 129 ]

1

[ "GP" ]

[ "GenProp1009" ]

[ "GP:GenProp1009" ]

1

[]

0

[ "PUB00007999", "PUB00008000" ]

[ "1833877", "2168966" ]

[ "Bovine coronavirus nonstructural protein ns2 is a phosphoprotein.", "Murine coronavirus nonstructural protein ns2 is not essential for virus replication in transformed cells." ]

[ 1991, 1990 ]

2

[]

0

null

[ "Coronaviridae" ]

[ 129 ]

1

[]

0

true

Family

Coronavirus nonstructural protein NS2

Corona_NS2

6

IPR006842

6,842

Transposase (putative), YhgA-like

Transposase_31

Domain

10,727

false

This is a domain found in a group of putative transposases, including the YhgA sequence from Escherichia coli ( ) and several prokaryotic homologues [ ].

[]

0

[ "PFAM" ]

[ "PF04754" ]

[ "Transposase_31" ]

[ 10727 ]

1

[ "EC" ]

[ "3.1.21.-" ]

[ "EC:3.1.21.-" ]

1

[]

0

[ "PUB00034642" ]

[ "8837478" ]

[ "Characterization and sequence of the Escherichia coli panBCD gene cluster." ]

[ 1996 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "Methanomicrobia", "Siphoviridae sp. ct5kv15", "unclassified sequences" ]

[ 10632, 48, 9, 1, 37 ]

5

[ "Escherichia coli (strain K12)" ]

[ 6 ]

1

true

Domain

Transposase (putative), YhgA-like

Transposase_31

1

IPR006843

6,843

Plastid lipid-associated protein/fibrillin conserved domain

PAP/fibrillin_dom

Domain

9,385

false

This entry represents a conserved domain found in a number of plastid lipid-associated proteins (PAPs), including Fibrillin-5 (FBN5) from Arabidopsis and CHRC from Oncidium hybrid cultivar. Fibrillins accumulate in chromoplasts and sequester carotenoids during the development of flowers and fruits [ ]. FBN5 has been sh...

[]

0

[ "PFAM" ]

[ "PF04755" ]

[ "PAP_fibrillin" ]

[ 9385 ]

1

[]

0

[]

0

[ "PUB00092853", "PUB00092854", "PUB00095653" ]

[ "28751900", "26432861", "9312067" ]

[ "Conserved Function of Fibrillin5 in the Plastoquinone-9 Biosynthetic Pathway in Arabidopsis and Rice.", "Fibrillin 5 Is Essential for Plastoquinone-9 Biosynthesis by Binding to Solanesyl Diphosphate Synthases in Arabidopsis.", "CHRC, encoding a chromoplast-specific carotenoid-associated protein, is an early gi...

[ 2017, 2015, 1997 ]

3

[]

0

null

[ "Bacteria", "Eukaryota" ]

[ 544, 8841 ]

2

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 61, 29, 58 ]

3

true

Domain

Plastid lipid-associated protein/fibrillin conserved domain

PAP/fibrillin_dom

5

IPR006846

6,846

Small ribosomal subunit protein eS30

Ribosomal_eS30

Family

4,772

false

This entry is for the ribosomal protein eS30. Ribosomes are the particles that catalyse mRNA-directed protein synthesis in all organisms. The codons of the mRNA are exposed on the ribosome to allow tRNA binding. This leads to the incorporation of amino acids into the growing polypeptide chain in accordance with the gen...

[ "GO:0003735", "GO:0006412", "GO:0005840" ]

[ "structural constituent of ribosome", "translation", "ribosome" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PFAM" ]

[ "PF04758" ]

[ "Ribosomal_S30" ]

[ 4772 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-HSA-156827", "R-HSA-156902", "R-HSA-1799339", "R-HSA-192823", "R-HSA-2408557", "R-HSA-6791226", "R-HSA-72649", "R-HSA-72689", "R-HSA-72695", "R-HSA-72702", "R-HSA-72706", "R-HSA-72764", "R-HSA-9010553", "R-HSA-9633012", "R-HSA-9735869", "R-HSA-9754678", "R-HSA-975956", "R-HSA-97...

[ "REACTOME:R-HSA-156827", "REACTOME:R-HSA-156902", "REACTOME:R-HSA-1799339", "REACTOME:R-HSA-192823", "REACTOME:R-HSA-2408557", "REACTOME:R-HSA-6791226", "REACTOME:R-HSA-72649", "REACTOME:R-HSA-72689", "REACTOME:R-HSA-72695", "REACTOME:R-HSA-72702", "REACTOME:R-HSA-72706", "REACTOME:R-HSA-72764...

28

[ "3j0l", "3j0o", "3j0p", "3j0q", "3j16", "3j6x", "3j6y", "3j77", "3j78", "3j7a", "3j7p", "3j7r", "3j80", "3j81", "3jag", "3jah", "3jai", "3jaj", "3jam", "3jan", "3jap", "3jbn", "3jbo", "3jbp", "4bts", "4d5l", "4d61", "4kzx", "4kzy", "4kzz", "4u3m", "4u3n"...

542

[ "PUB00007068", "PUB00007069", "PUB00007070" ]

[ "11297922", "11290319", "11114498" ]

[ "Atomic structures at last: the ribosome in 2000.", "The ribosome in focus.", "The end of the beginning: structural studies of ribosomal proteins." ]

[ 2001, 2001, 2000 ]

3

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "metagenomes" ]

[ 216, 3, 4533, 2, 18 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 3, 1, 2, 2, 3, 6, 2, 5, 9, 2, 2, 6 ]

12

true

Family

Small ribosomal subunit protein eS30

Ribosomal_eS30

6

IPR006847

6,847

Translation initiation factor IF-2, N-terminal

IF2_N

Domain

28,963

false

This region is found in the N-terminal half of translation initiation factor IF-2. It is found in two copies in IF-2 alpha isoforms, and in only one copy in the N-terminally truncated beta and gamma isoforms [ ]. Its function is unknown.

[]

0

[ "PFAM" ]

[ "PF04760" ]

[ "IF2_N" ]

[ 28963 ]

1

[]

0

[ "1nd9", "3j4j", "3jcj", "3jcn", "4b3x", "4b43", "4b44", "4b47", "4b48", "4kjz", "5lmv", "5me0", "5me1", "7uiu", "7unq", "7unr", "7unt", "7unu", "7unv", "7unw", "9h9h" ]

21

[ "PUB00008614" ]

[ "1764105" ]

[ "Tandem translation of E. coli initiation factor IF2 beta: purification and characterization in vitro of two active forms." ]

[ 1991 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "Methanobacteriota", "unclassified Caudoviricetes", "unclassified sequences" ]

[ 26562, 1870, 6, 2, 523 ]

5

[ "Arabidopsis thaliana", "Escherichia coli (strain K12)", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)", "Zea mays" ]

[ 3, 1, 1, 3, 1, 1, 4 ]

7

true

Domain

Translation initiation factor IF-2, N-terminal

IF2_N

5

IPR006848

6,848

Transcription regulator, putative, lactococcus phage-type

Transcrpt_reg_put_lact_phage

Family

57

false

This family represents a number of putative transcription repressor proteins found in several Lactococcus bacteriophages. Horizontal transfer may account for the presence of similar proteins in Lactococcus species [ ].

[]

0

[ "PFAM" ]

[ "PF04761" ]

[ "Phage_Treg" ]

[ 57 ]

1

[]

0

[]

0

[ "PUB00008615" ]

[ "11337471" ]

[ "The complete genome sequence of the lactic acid bacterium Lactococcus lactis ssp. lactis IL1403." ]

[ 2001 ]

1

[]

0

null

[ "Caudoviricetes", "Lactobacillales" ]

[ 5, 52 ]

2

[]

0

true

Family

Transcription regulator, putative, lactococcus phage-type

Transcrpt_reg_put_lact_phage

7

IPR006849

6,849

Elongator complex protein 1

Elp1

Family

5,538

false

Elongator complex protein 1 (also known as Iki3) is a component of the RNA polymerase II elongator complex, which is a major histone acetyltransferase component of the RNA polymerase II (RNAPII) holoenzyme. The eukaryotic elongator complex has been associated with many cellular activities, including transcriptional elo...

[ "GO:0002098", "GO:0033588" ]

[ "tRNA wobble uridine modification", "elongator holoenzyme complex" ]

[ "biological_process", "cellular_component" ]

2

[ "PIRSF", "PANTHER" ]

[ "PIRSF017233", "PTHR12747" ]

[ "IKAP", "" ]

[ 3965, 5538 ]

2

[ "REACTOME" ]

[ "R-HSA-3214847" ]

[ "REACTOME:R-HSA-3214847" ]

1

[ "5cqr", "5cqs", "6qk7", "8asv", "8asw", "8avg", "8ptx", "8pty", "8ptz", "8pu0" ]

10

[ "PUB00008616", "PUB00019998", "PUB00043578", "PUB00086633", "PUB00086635" ]

[ "10024884", "11689709", "15769872", "22889844", "23165209" ]

[ "Elongator, a multisubunit component of a novel RNA polymerase II holoenzyme for transcriptional elongation.", "Characterization of a six-subunit holo-elongator complex required for the regulated expression of a group of genes in Saccharomyces cerevisiae.", "An early step in wobble uridine tRNA modification req...

[ 1999, 2001, 2005, 2012, 2012 ]

5

[]

0

null

[ "Eukaryota", "Streptomyces javensis" ]

[ 5537, 1 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 5, 1, 6, 5, 30, 2, 1, 4, 4, 1, 1, 7 ]

12

true

Family

Elongator complex protein 1

Elp1

8

IPR006850

6,850

Domain of unknown function DUF562

DUF562

Domain

27

false

This represents a conserved region found in a number of Chlamydophila pneumoniae proteins.

[]

0

[ "PFAM" ]

[ "PF04763" ]

[ "DUF562" ]

[ 27 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Chlamydia" ]

[ 27 ]

1

[]

0

true

Domain

Domain of unknown function DUF562

DUF562

1

IPR006851

6,851

Protein of unknown function DUF613

DUF613

Family

8

false

This is a family of chloroplast proteins of unknown function. Some members have two copies of the conserved region.

[]

0

[ "PFAM" ]

[ "PF04764" ]

[ "DUF613" ]

[ 8 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Eukaryota" ]

[ 8 ]

1

[]

0

true

Family

Protein of unknown function DUF613

DUF613

2

IPR006853

6,853

Poxin, virus

Poxin_vir

Family

337

false

This entry represents Poxin (poxvirus immune nucleases) from Baculovirus and Vaccinia virus. Poxin is a nuclease that cleaves host 2',3'-cGAMP [ ]. In human hosts, enzyme cGAS recognizes cytosolic DNA and synthesizes 2'3' cGAMP to activate STING-dependent interferon and NF-kappaB immune responses. Poxin is the viral fa...

[ "GO:0004518" ]

[ "nuclease activity" ]

[ "molecular_function" ]

1

[ "HAMAP", "PFAM" ]

[ "MF_04143", "PF04766" ]

[ "Poxins", "Baculo_p26" ]

[ 272, 273 ]

2

[]

0

[ "6ea6", "6ea8", "6ea9", "6xb3", "6xb5", "6xb6", "7wn7", "8c9k", "8orv", "8p44" ]

10

[ "PUB00092858" ]

[ "30728498" ]

[ "Viral and metazoan poxins are cGAMP-specific nucleases that restrict cGAS-STING signalling." ]

[ 2019 ]

1

[]

0

null

[ "Endopterygota", "Viruses" ]

[ 66, 271 ]

2

[]

0

true

Family

Poxin, virus

Poxin_vir

4

IPR006854

6,854

Phosphoprotein F17

Phosphoprotein_F17

Family

110

false

This is a family of poxvirus proteins required for virus morphogenesis and infectivity [ ]. Phosphoprotein F17 is necessary for proteolytic processing of the major viral structural proteins, P4a and P4b [ ]. F17 binds and sequesters Raptor and Rictor, regulators of mammalian target of rapamycin complexes mTORC1 and mTO...

[ "GO:0003677", "GO:0019082" ]

[ "DNA binding", "viral protein processing" ]

[ "molecular_function", "biological_process" ]

2

[ "PFAM", "PIRSF" ]

[ "PF04767", "PIRSF003688" ]

[ "Pox_F17", "VAC_PP" ]

[ 110, 106 ]

2

[]

0

[]

0

[ "PUB00008617", "PUB00090982", "PUB00090983" ]

[ "1920628", "30078703", "20392848" ]

[ "Vaccinia virus morphogenesis is interrupted when expression of the gene encoding an 11-kilodalton phosphorylated protein is prevented by the Escherichia coli lac repressor.", "Poxviruses Evade Cytosolic Sensing through Disruption of an mTORC1-mTORC2 Regulatory Circuit.", "Structure/Function analysis of the vac...

[ 1991, 2018, 2010 ]

3

[]

0

null

[ "Chordopoxvirinae" ]

[ 110 ]

1

[]

0

true

Family

Phosphoprotein F17

Phosphoprotein_F17

3

IPR006855

6,855

Vertebrate-like NAGS Gcn5-related N-acetyltransferase (GNAT) domain

Vertebrate-like_GNAT_dom

Domain

4,730

false

The N-acetyltransferases (NAT) (EC 2.3.1.-) are enzymes that use acetyl coenzyme A (CoA) to transfer an acetyl group to a substrate, a reaction implicated in various functions from bacterial antibiotic resistance to mammalian circadian rhythm and chromatin remodeling. The Gcn5-related N-acetyltransferases (GNAT) cataly...

[]

0

[ "PFAM", "PROFILE" ]

[ "PF04768", "PS51731" ]

[ "NAT", "GNAT_NAGS" ]

[ 4728, 4686 ]

2

[ "EC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "2.3.1.1", "PWY-5154", "R-DDI-70635", "R-DRE-70635", "R-HSA-70635", "R-MMU-70635", "R-SCE-70635", "R-SPO-70635" ]

[ "EC:2.3.1.1", "METACYC:PWY-5154", "REACTOME:R-DDI-70635", "REACTOME:R-DRE-70635", "REACTOME:R-HSA-70635", "REACTOME:R-MMU-70635", "REACTOME:R-SCE-70635", "REACTOME:R-SPO-70635" ]

8

[ "3s6g", "3s6h", "3s6k", "3s7y", "3zzi", "4ab7", "4k30", "4kzt", "4nex", "4nf1" ]

10

[ "PUB00005463", "PUB00025257", "PUB00027579", "PUB00033792", "PUB00033793", "PUB00074836" ]

[ "9175471", "12527305", "12592013", "10940244", "15581578", "23894642" ]

[ "GCN5-related histone N-acetyltransferases belong to a diverse superfamily that includes the yeast SPT10 protein.", "Crystal structure of tabtoxin resistance protein complexed with acetyl coenzyme A reveals the mechanism for beta-lactam acetylation.", "X-ray structure of the AAC(6')-Ii antibiotic resistance enz...

[ 1997, 2003, 2003, 2000, 2005, 2013 ]

6

[]

0

null

[ "Bacteria", "Candidatus Iainarchaeum sp.", "Eukaryota", "ecological metagenomes" ]

[ 646, 1, 4077, 6 ]

4

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 2, 3, 1, 3, 3, 2, 2 ]

7

true

Domain

Vertebrate-like NAGS Gcn5-related N-acetyltransferase (GNAT) domain

Vertebrate-like_GNAT_dom

1

IPR006856

6,856

Mating-type protein MAT alpha 1, HMG-box

MATalpha_HMGbox

Domain

1,725

false

This entry represents the MAT Alpha1 domain, which is diverged from the MATA HMG-box domain [ ]. All ascomycete MAT idiomorphs encode proteins with confirmed or putative DNA-binding motifs [ , ]. The HMG-box domain can be found in a wide variety of DNA-binding proteins.

[ "GO:0008301", "GO:0007531", "GO:0045895", "GO:0005634" ]

[ "DNA binding, bending", "mating type determination", "positive regulation of mating-type specific transcription, DNA-templated", "nucleus" ]

[ "molecular_function", "biological_process", "biological_process", "cellular_component" ]

4

[ "PFAM", "PROFILE" ]

[ "PF04769", "PS51325" ]

[ "MATalpha_HMGbox", "ALPHA_BOX" ]

[ 1663, 1581 ]

2

[]

0

[]

0

[ "PUB00015134", "PUB00015135", "PUB00043783", "PUB00043784", "PUB00075701" ]

[ "15118075", "8339934", "11106025", "12679880", "21170349" ]

[ "Alpha1-induced DNA bending is required for transcriptional activation by the Mcm1-alpha1 complex.", "Coupling of cell identity to signal response in yeast: interaction between the alpha 1 and STE12 proteins.", "Mating-type genes from asexual phytopathogenic ascomycetes Fusarium oxysporum and Alternaria alterna...

[ 2004, 1993, 2000, 2003, 2010 ]

5

[]

0

null

[ "Dictyobacter", "Fungi" ]

[ 3, 1722 ]

2

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)" ]

[ 2, 2 ]

2

true

Domain

Mating-type protein MAT alpha 1, HMG-box

MATalpha_HMGbox

7

IPR006858

6,858

Chicken anaemia virus VP-3 protein

CAV_VP3

Family

210

false

Chicken anaemia virus (CAV) is a circovirus which can cause severe depletion of some cell types, such as lymphocytes, by the induction of apoptosis [ ]. Studies indicate that expression of the viral VP3 protein, also known as apoptin, is sufficient to induce apoptosis in susceptible cells and to produce the doughnut-sh...

[ "GO:0052151" ]

[ "symbiont-mediated activation of host apoptosis" ]

[ "biological_process" ]

1

[ "PFAM" ]

[ "PF04771" ]

[ "CAV_VP3" ]

[ 210 ]

1

[]

0

[]

0

[ "PUB00033910", "PUB00033911" ]

[ "14741120", "15258463" ]

[ "Chicken anemia virus induced apoptosis: underlying molecular mechanisms.", "The viral death effector Apoptin reveals tumor-specific processes." ]

[ 2004, 2004 ]

2

[]

0

null

[ "Gyrovirus" ]

[ 210 ]

1

[]

0

true

Family

Chicken anaemia virus VP-3 protein

CAV_VP3

6

IPR006859

6,859

Influenza B matrix protein 2

Flu_B_M2

Family

7,004

false

BM2 is integral membrane protein that displays H(+) ion channel activity that plays critical roles in production of infectious virus. It is synthesised in the late phase of infection and incorporated into the virion. The cytoplasmic domain of the BM2 protein is required for firm association of the M1 protein with lipid...

[ "GO:1902600", "GO:0016020" ]

[ "proton transmembrane transport", "membrane" ]

[ "biological_process", "cellular_component" ]

2

[ "PFAM" ]

[ "PF04772" ]

[ "Flu_B_M2" ]

[ 7004 ]

1

[ "GP" ]

[ "GenProp1013" ]

[ "GP:GenProp1013" ]

1

[ "2kix", "2kj1", "6pvr", "6pvt" ]

4

[ "PUB00069138" ]

[ "17989175" ]

[ "Cytoplasmic domain of influenza B virus BM2 protein plays critical roles in production of infectious virus." ]

[ 2008 ]

1

[]

0

null

[ "Orthomyxoviridae" ]

[ 7004 ]

1

[]

0

true

Family

Influenza B matrix protein 2

Flu_B_M2

4

IPR006861

6,861

Hyaluronan/mRNA-binding protein

HABP4_PAIRBP1-bd

Domain

8,179

false

This entry represents a domain found in the HABP4 protein family of hyaluronan-binding proteins, and the PAI-1 mRNA-binding protein, PAI-RBP1. HABP4 has been observed to bind hyaluronan (a glucosaminoglycan), but it is not known whether this is its primary role in vivo . It has also been observed to bind RNA, but with ...

[]

0

[ "PFAM", "SMART" ]

[ "PF04774", "SM01233" ]

[ "HABP4_PAI-RBP1", "HABP4_PAI-RBP1" ]

[ 6970, 7353 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-DDI-114608", "R-GGA-114608", "R-HSA-114608", "R-MMU-114608", "R-RNO-114608", "R-SCE-114608", "R-SPO-114608" ]

[ "REACTOME:R-DDI-114608", "REACTOME:R-GGA-114608", "REACTOME:R-HSA-114608", "REACTOME:R-MMU-114608", "REACTOME:R-RNO-114608", "REACTOME:R-SCE-114608", "REACTOME:R-SPO-114608" ]

7

[ "4u3m", "4u3n", "4u3u", "4u4n", "4u4o", "4u4q", "4u4r", "4u4u", "4u4y", "4u4z", "4u50", "4u51", "4u52", "4u53", "4u55", "4u56", "4u6f", "4v6w", "4v6x", "5dat", "5dc3", "5dge", "5mei", "5ndg", "5ndv", "5ndw", "5obm", "5on6", "5tbw", "6hhq", "6mte", "6z6m"...

77

[ "PUB00008623", "PUB00008624", "PUB00053771", "PUB00053772" ]

[ "10887182", "11001948", "14699138", "16455055" ]

[ "Molecular characterization of a novel intracellular hyaluronan-binding protein.", "Identification and cDNA cloning of a novel RNA-binding protein that interacts with the cyclic nucleotide-responsive sequence in the Type-1 plasminogen activator inhibitor mRNA.", "Ki-1/57 interacts with RACK1 and is a substrate ...

[ 2000, 2001, 2004, 2006 ]

4

[]

0

null

[ "Eukaryota" ]

[ 8179 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 14, 1, 6, 8, 6, 12, 1, 12, 6, 1, 1, 26 ]

12

true

Domain

Hyaluronan/mRNA-binding protein

HABP4_PAIRBP1-bd

6

IPR006862

6,862

Acyl-CoA thioester hydrolase/bile acid-CoA amino acid N-acetyltransferase

Thio_Ohase/aa_AcTrfase

Domain

6,511

false

This entry presents the N-termini of acyl-CoA thioester hydrolase and bile acid-CoA:amino acid N-acetyltransferase (BAAT) [ ]. This region is not thought to contain the active site of either enzyme. Thioesterase isoforms have been identified in peroxisomes, cytoplasm and mitochondria, where they are thought to have dis...

[]

0

[ "PFAM" ]

[ "PF04775" ]

[ "Bile_Hydr_Trans" ]

[ 6511 ]

1

[ "EC", "EC", "GP", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REA...

[ "3.1.2", "3.1.2.2", "GenProp1587", "PWY-1121", "PWY-321", "PWY-5972", "PWY-5996", "PWY-6733", "PWY-7723", "R-HSA-159418", "R-HSA-193368", "R-HSA-390247", "R-HSA-77289", "R-HSA-9033241", "R-HSA-9837999", "R-MMU-159418", "R-MMU-193368", "R-MMU-390247", "R-MMU-77289", "R-MMU-90332...

[ "EC:3.1.2", "EC:3.1.2.2", "GP:GenProp1587", "METACYC:PWY-1121", "METACYC:PWY-321", "METACYC:PWY-5972", "METACYC:PWY-5996", "METACYC:PWY-6733", "METACYC:PWY-7723", "REACTOME:R-HSA-159418", "REACTOME:R-HSA-193368", "REACTOME:R-HSA-390247", "REACTOME:R-HSA-77289", "REACTOME:R-HSA-9033241", ...

26

[ "3hlk", "3k2i" ]

2

[ "PUB00008625", "PUB00008626" ]

[ "11673457", "10567408" ]

[ "Characterization of an acyl-coA thioesterase that functions as a major regulator of peroxisomal lipid metabolism.", "Peroxisome proliferator-induced long chain acyl-CoA thioesterases comprise a highly conserved novel multi-gene family involved in lipid metabolism." ]

[ 2002, 1999 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "Stenosarchaea group", "metagenomes" ]

[ 1087, 5368, 48, 8 ]

4

[ "Caenorhabditis elegans", "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 5, 34, 13, 20, 24 ]

5

true

Domain

Acyl-CoA thioester hydrolase/bile acid-CoA amino acid N-acetyltransferase

Thio_Ohase/aa_AcTrfase

2

IPR006864

6,864

LMP repeat

LMP_rpt

Repeat

36

false

This repeated sequence element is found in the LMP group of surface-located membrane proteins of Mycoplasma hominis. The the number of repeats in the protein affects the tendency of cells to spontaneously aggregate. Agglutination may be an important factor in colonization. Non-agglutinating microorganisms might easily ...

[]

0

[ "PFAM" ]

[ "PF04778" ]

[ "LMP" ]

[ 36 ]

1

[]

0

[]

0

[ "PUB00008629" ]

[ "7543881" ]

[ "Selection of Mycoplasma hominis PG21 deletion mutants by cultivation in the presence of monoclonal antibody 552." ]

[ 1995 ]

1

[]

0

null

[ "Bacteria", "Eukaryota" ]

[ 33, 3 ]

2

[]

0

true

Repeat

LMP repeat

LMP_rpt

3

IPR006865

6,865

Domain of unknown function DUF629

DUF629

Domain

2,147

false

This domain represents a region of several plant proteins of unknown function. A C2H2 zinc finger is predicted in this region in some family members, but the spacing between the cysteine residues is not conserved throughout the family.

[]

0

[ "PFAM" ]

[ "PF04780" ]

[ "DUF629" ]

[ 2147 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Eukaryota" ]

[ 2, 2145 ]

2

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 110, 42, 51 ]

3

true

Domain

Domain of unknown function DUF629

DUF629

8

IPR006866

6,866

Domain of unknown function DUF627, N-terminal

DUF627_N

Domain

1,431

false

This domain represents the N-terminal region of several plant proteins of unknown function.

[]

0

[ "PFAM" ]

[ "PF04781" ]

[ "DUF627" ]

[ 1431 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Embryophyta", "Roseihalotalea indica" ]

[ 1430, 1 ]

2

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 104, 2, 32 ]

3

true

Domain

Domain of unknown function DUF627, N-terminal

DUF627_N

6