interpro_id string | interpro_numeric_id int64 | name string | short_name string | entry_type string | protein_count int64 | is_llm bool | is_llm_reviewed bool | abstract string | go_ids list | go_terms list | go_categories list | go_count int64 | member_databases list | member_accessions list | member_names list | member_protein_counts list | member_count int64 | external_databases list | external_accessions list | external_xrefs list | external_xref_count int64 | pdb_ids list | structure_count int64 | publication_ids list | pubmed_ids list | publication_titles list | publication_years list | publication_count int64 | parent_ids list | child_ids list | parent_count int64 | child_count int64 | tree_depth float64 | taxonomy_names list | taxonomy_protein_counts list | taxonomy_count int64 | key_species_names list | key_species_protein_counts list | key_species_count int64 | in_entry_list bool | entry_list_type string | entry_list_name string | names_dat_name string | short_names_dat_name string | split_bucket int64 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
IPR008403 | 8,403 | Apolipoprotein CIII | Apo-CIII | Family | 430 | false | false | Apolipoprotein C-III is a 79-residue glycoprotein synthesised in the intestine and liver as part of the very low density lipoprotein (VLDL) and the high density lipoprotein (HDL) particles. Owing to its positive correlation with plasma triglyceride (Tg) levels, Apo-CIII is suggested to play a role in Tg metabolism and ... | [
"GO:0008289",
"GO:0006869",
"GO:0042157",
"GO:0005576"
] | [
"lipid binding",
"lipid transport",
"lipoprotein metabolic process",
"extracellular region"
] | [
"molecular_function",
"biological_process",
"biological_process",
"cellular_component"
] | 4 | [
"PFAM",
"PANTHER"
] | [
"PF05778",
"PTHR14225"
] | [
"Apo-CIII",
""
] | [
426,
428
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-8963888",
"R-BTA-8963901",
"R-BTA-8964058",
"R-BTA-975634",
"R-HSA-8963888",
"R-HSA-8963901",
"R-HSA-8964058",
"R-HSA-975634",
"R-MMU-8963888",
"R-MMU-8963901",
"R-MMU-8964058",
"R-MMU-975634",
"R-RNO-8963888",
"R-RNO-8963901",
"R-RNO-8964058",
"R-RNO-975634",
"R-SSC-8963888",... | [
"REACTOME:R-BTA-8963888",
"REACTOME:R-BTA-8963901",
"REACTOME:R-BTA-8964058",
"REACTOME:R-BTA-975634",
"REACTOME:R-HSA-8963888",
"REACTOME:R-HSA-8963901",
"REACTOME:R-HSA-8964058",
"REACTOME:R-HSA-975634",
"REACTOME:R-MMU-8963888",
"REACTOME:R-MMU-8963901",
"REACTOME:R-MMU-8964058",
"REACTOME:... | 20 | [
"2jq3"
] | 1 | [
"PUB00011250"
] | [
"12082170"
] | [
"Lipid-interacting properties of the N-terminal domain of human apolipoprotein C-III."
] | [
2002
] | 1 | [] | [] | 0 | 0 | null | [
"Bilateria"
] | [
430
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
4,
4,
7
] | 3 | true | Family | Apolipoprotein CIII | Apolipoprotein CIII | Apo-CIII | 7 |
IPR008404 | 8,404 | Apovitellenin I | Apo-VLDL-II | Family | 414 | false | false | This family consists of several avian apovitellenin I sequences. As part of the avian reproductive effort, large quantities of triglyceride-rich very-low-density lipoprotein (VLDL) particles are transported by receptor-mediated endocytosis into the female germ cells. Although the oocytes are surrounded by a layer of gr... | [
"GO:0004857",
"GO:0006629",
"GO:0042627"
] | [
"enzyme inhibitor activity",
"lipid metabolic process",
"chylomicron"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PFAM",
"PIRSF"
] | [
"PF05418",
"PIRSF002369"
] | [
"Apo-VLDL-II",
"Apo-VLDL-II"
] | [
414,
211
] | 2 | [] | [] | [] | 0 | [] | 0 | [
"PUB00011251"
] | [
"8713091"
] | [
"Molecular characterization of quail apolipoprotein very-low-density lipoprotein II: disulphide-bond-mediated dimerization is not essential for inhibition of lipoprotein lipase."
] | [
1996
] | 1 | [] | [] | 0 | 0 | null | [
"Tetrapoda"
] | [
414
] | 1 | [] | [] | 0 | true | Family | Apovitellenin I | Apovitellenin I | Apo-VLDL-II | 3 |
IPR008405 | 8,405 | Apolipoprotein L | ApoL | Family | 5,786 | false | false | Apo L belongs to the high density lipoprotein family that plays a central role in cholesterol transport. The cholesterol content of membranes is important in cellular processes such as modulating gene transcription and signal transduction both in the adult brain and during neurodevelopment. There are six apo L genes lo... | [
"GO:0008289",
"GO:0006869",
"GO:0042157",
"GO:0005576"
] | [
"lipid binding",
"lipid transport",
"lipoprotein metabolic process",
"extracellular region"
] | [
"molecular_function",
"biological_process",
"biological_process",
"cellular_component"
] | 4 | [
"PFAM",
"PANTHER"
] | [
"PF05461",
"PTHR14096"
] | [
"ApoL",
""
] | [
5534,
5466
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-2168880",
"R-HSA-381426",
"R-HSA-8957275"
] | [
"REACTOME:R-HSA-2168880",
"REACTOME:R-HSA-381426",
"REACTOME:R-HSA-8957275"
] | 3 | [
"7l6k",
"7lf7",
"7lf8",
"7lfa",
"7lfb"
] | 5 | [
"PUB00011252",
"PUB00053845",
"PUB00053846"
] | [
"11930015",
"12621437",
"16847577"
] | [
"Gene expression analysis in schizophrenia: reproducible up-regulation of several members of the apolipoprotein L family located in a high-susceptibility locus for schizophrenia on chromosome 22.",
"Apolipoprotein L-I is the trypanosome lytic factor of human serum.",
"The function of apolipoproteins L."
] | [
2002,
2003,
2006
] | 3 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota"
] | [
6,
5780
] | 2 | [
"Caenorhabditis elegans",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
79,
162,
31,
21
] | 5 | true | Family | Apolipoprotein L | Apolipoprotein L | ApoL | 1 |
IPR008406 | 8,406 | Dormancy/auxin associated protein | DRM/ARP | Family | 2,819 | false | false | This family contains several plant dormancy-associated and auxin-repressed proteins [ ]. The expression of the DRM/ARP family members may be regulated by stress and environmental factors [ ]. | [] | [] | [] | 0 | [
"PFAM",
"PANTHER"
] | [
"PF05564",
"PTHR33565"
] | [
"Auxin_repressed",
""
] | [
2753,
2717
] | 2 | [] | [] | [] | 0 | [] | 0 | [
"PUB00011253",
"PUB00079181"
] | [
"9684359",
"24442277"
] | [
"Dormancy-associated gene expression in pea axillary buds. Cloning and expression of PsDRM1 and PsDRM2.",
"DRM1 and DRM2 expression regulation: potential role of splice variants in response to stress and environmental factors in Arabidopsis."
] | [
1998,
2014
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota"
] | [
2,
2817
] | 2 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
26,
14,
29
] | 3 | true | Family | Dormancy/auxin associated protein | Dormancy/auxin associated protein | DRM/ARP | 9 |
IPR008407 | 8,407 | Branched-chain amino acid transport, AzlD | Brnchd-chn_aa_trnsp_AzlD | Family | 21,099 | false | false | This family consists of a number of bacterial and archaeal branched-chain amino acid transport proteins. AzlD, a member of this group, is encoded by a gene part of the of the azl operon which is involved in branched-chain amino acid transport [ ]. AzlCD is a bipartite histidine exporter consisting of AzlC and AzlD subu... | [] | [] | [] | 0 | [
"PFAM",
"PIRSF"
] | [
"PF05437",
"PIRSF003203"
] | [
"AzlD",
"AzlD"
] | [
21099,
2484
] | 2 | [] | [] | [] | 0 | [] | 0 | [
"PUB00011254",
"PUB00152867"
] | [
"9287000",
"36377869"
] | [
"An lrp-like gene of Bacillus subtilis involved in branched-chain amino acid transport.",
"How To Deal with Toxic Amino Acids: the Bipartite AzlCD Complex Exports Histidine in <i>Bacillus subtilis</i>."
] | [
1997,
2022
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Methanobacteriota",
"unclassified sequences"
] | [
20413,
12,
427,
247
] | 4 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Branched-chain amino acid transport, AzlD | Branched-chain amino acid transport, AzlD | Brnchd-chn_aa_trnsp_AzlD | 4 |
IPR008408 | 8,408 | Brain acid soluble protein 1 | BASP1 | Family | 857 | false | false | This family consists of several brain acid soluble protein 1 (BASP1) or neuronal axonal membrane protein NAP-22. The BASP1 is a neuron enriched Ca 2+ -dependent calmodulin-binding protein of unknown function [ , ]. | [] | [] | [] | 0 | [
"PFAM",
"PANTHER"
] | [
"PF05466",
"PTHR23212"
] | [
"BASP1",
""
] | [
856,
800
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-9035034",
"R-DRE-9035034",
"R-GGA-9035034",
"R-HSA-9035034",
"R-MMU-9035034",
"R-RNO-9035034"
] | [
"REACTOME:R-BTA-9035034",
"REACTOME:R-DRE-9035034",
"REACTOME:R-GGA-9035034",
"REACTOME:R-HSA-9035034",
"REACTOME:R-MMU-9035034",
"REACTOME:R-RNO-9035034"
] | 6 | [] | 0 | [
"PUB00011546",
"PUB00011547"
] | [
"9310187",
"10965107"
] | [
"The BASP1 family of myristoylated proteins abundant in axonal termini. Primary structure analysis and physico-chemical properties.",
"Assignment of brain acid-soluble protein 1 (BASP1) to human chromosome 5p15.1-->p14, differential expression in human cancer cell lines as a result of alterations in gene dosage."... | [
1997,
2000
] | 2 | [] | [] | 0 | 0 | null | [
"Vertebrata"
] | [
857
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
2,
2,
5
] | 4 | true | Family | Brain acid soluble protein 1 | Brain acid soluble protein 1 | BASP1 | 2 |
IPR008409 | 8,409 | Pre-mRNA-splicing factor SPF27 | SPF27 | Family | 4,250 | false | false | Proteins in this family are involved in mRNA splicing [ ]. This family includes pre-mRNA-splicing factor SPF27, SNT309 and Cwf7. In humans, SPF27 is a component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. It may have a scaffolding role in t... | [
"GO:0006397"
] | [
"mRNA processing"
] | [
"biological_process"
] | 1 | [
"PFAM",
"PANTHER"
] | [
"PF05700",
"PTHR13296"
] | [
"BCAS2",
""
] | [
4246,
4065
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-DDI-72163",
"R-DRE-72163",
"R-HSA-72163",
"R-MMU-72163",
"R-SPO-72163",
"R-XTR-72163"
] | [
"REACTOME:R-DDI-72163",
"REACTOME:R-DRE-72163",
"REACTOME:R-HSA-72163",
"REACTOME:R-MMU-72163",
"REACTOME:R-SPO-72163",
"REACTOME:R-XTR-72163"
] | 6 | [
"3jb9",
"5mqf",
"5xjc",
"5yzg",
"5z56",
"5z57",
"6ff7",
"6icz",
"6id0",
"6id1",
"6qdv",
"7a5p",
"7w59",
"7w5a",
"7w5b",
"8c6j",
"8ch6",
"8i0t",
"8i0u",
"8i0v",
"8i0w",
"8ro0",
"8ro1",
"8ro2",
"8xi2",
"9esh",
"9esi",
"9fmd",
"9l5r",
"9l5s",
"9l5t"
] | 31 | [
"PUB00063011",
"PUB00063012"
] | [
"17575050",
"20176811"
] | [
"Regulation of plant innate immunity by three proteins in a complex conserved across the plant and animal kingdoms.",
"Molecular architecture of the human Prp19/CDC5L complex."
] | [
2007,
2010
] | 2 | [] | [] | 0 | 0 | null | [
"Alkalimarinus sediminis",
"Eukaryota"
] | [
1,
4249
] | 2 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Schizosaccharomyces pombe (stra... | [
3,
2,
1,
1,
3,
4,
1,
2,
6,
1,
7
] | 11 | true | Family | Pre-mRNA-splicing factor SPF27 | Pre-mRNA-splicing factor SPF27 | SPF27 | 3 |
IPR008410 | 8,410 | Cellulose synthase operon C, C-terminal | BCSC_C | Domain | 3,922 | false | false | This entry contains the C-terminal regions of several bacterial cellulose synthase operon C (BCSC) proteins. BCSC is involved in cellulose synthesis although the exact function of this protein is unknown [ ]. | [
"GO:0030244",
"GO:0019867"
] | [
"cellulose biosynthetic process",
"outer membrane"
] | [
"biological_process",
"cellular_component"
] | 2 | [
"PFAM"
] | [
"PF05420"
] | [
"BCSC_C"
] | [
3922
] | 1 | [
"GP",
"REACTOME"
] | [
"GenProp0658",
"R-HSA-9931953"
] | [
"GP:GenProp0658",
"REACTOME:R-HSA-9931953"
] | 2 | [
"6tzk",
"9b8a",
"9b8h"
] | 3 | [
"PUB00011257"
] | [
"11260463"
] | [
"The multicellular morphotypes of Salmonella typhimurium and Escherichia coli produce cellulose as the second component of the extracellular matrix."
] | [
2001
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Opisthokonta",
"metagenomes"
] | [
3896,
5,
21
] | 3 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Domain | Cellulose synthase operon C, C-terminal | Cellulose synthase operon C, C-terminal | BCSC_C | 1 |
IPR008412 | 8,412 | Integrin-binding sialoprotein | IBSP | Family | 548 | false | false | This entry represents human Integrin-binding sialoprotein, also known as Bone sialoprotein 2, and similar proteins mainly found in animals. The major non-collagenous matrix proteins (chondroitin-sulphate glycoproteins decorin and biglycan, sialoproteins osteopontin and bone sialoprotein, osteocalcin and osteonectin) ha... | [
"GO:0001503",
"GO:0007155",
"GO:0005576"
] | [
"ossification",
"cell adhesion",
"extracellular region"
] | [
"biological_process",
"biological_process",
"cellular_component"
] | 3 | [
"PFAM",
"PANTHER"
] | [
"PF05432",
"PTHR10345"
] | [
"BSP_II",
""
] | [
545,
521
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-216083",
"R-HSA-216083",
"R-HSA-3000178",
"R-MMU-216083",
"R-RNO-216083"
] | [
"REACTOME:R-BTA-216083",
"REACTOME:R-HSA-216083",
"REACTOME:R-HSA-3000178",
"REACTOME:R-MMU-216083",
"REACTOME:R-RNO-216083"
] | 5 | [] | 0 | [
"PUB00011259",
"PUB00011260",
"PUB00053844",
"PUB00099946",
"PUB00099947",
"PUB00099948"
] | [
"8061918",
"10785518",
"10759428",
"27881474",
"24530278",
"24071501"
] | [
"Characterization of the human bone sialoprotein (BSP) gene and its promoter sequence.",
"Expression of bone sialoprotein in mineralized tissues of tooth and bone and in buccal-pouch carcinomas of Syrian golden hamsters.",
"Bone sialoprotein.",
"Cancer Secretome May Influence BSP and DSP Expression in Human S... | [
1994,
2000,
1999,
2017,
2014,
2014
] | 6 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
548
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
2,
6
] | 3 | true | Family | Integrin-binding sialoprotein | Integrin-binding sialoprotein | IBSP | 4 |
IPR008414 | 8,414 | Hemolysin BL-binding component | HBL | Family | 2,242 | false | false | This entry consists of the hemolysin BL-binding component. Hemolysin BL is an enterotoxin and is composed of a binding component, B, and two lytic components, L1 and L2. Hemolysin BL is responsible for binding to erythrocytes and is thought to be the cause of the diarrheal form of gastroenteritis caused by food-borne s... | [
"GO:0016020"
] | [
"membrane"
] | [
"cellular_component"
] | 1 | [
"PFAM"
] | [
"PF05791"
] | [
"Bacillus_HBL"
] | [
2242
] | 1 | [] | [] | [] | 0 | [
"2nrj",
"4k1p",
"6dfp",
"6ezv",
"6grj",
"6grk",
"6h2f",
"6zz5",
"6zzh",
"7a0g",
"7nmq",
"7p3r"
] | 12 | [
"PUB00062403",
"PUB00062404"
] | [
"7693651",
"8319899"
] | [
"Molecular cloning and characterization of the hblA gene encoding the B component of hemolysin BL from Bacillus cereus.",
"Sphingomyelinase is part of the 'enterotoxin complex' produced by Bacillus cereus."
] | [
1993,
1993
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
2205,
35,
2
] | 3 | [] | [] | 0 | true | Family | Hemolysin BL-binding component | Hemolysin BL-binding component | HBL | 7 |
IPR008416 | 8,416 | Baculovirus VP1054 | Baculo_VP1054 | Family | 141 | false | false | This family consists of several VP1054 proteins from the Baculoviruses. VP1054 (also known as AC54) is a virus structural protein required for nucleocapsid assembly [ ]. It is necessary for localization of the major capsid protein VP39 at the site of nucleocapsid assembly [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF05789"
] | [
"Baculo_VP1054"
] | [
141
] | 1 | [] | [] | [] | 0 | [
"9h2h"
] | 1 | [
"PUB00011264",
"PUB00081415"
] | [
"9188569",
"26865720"
] | [
"Identification and characterization of a baculovirus structural protein, VP1054, required for nucleocapsid formation.",
"The Autographa californica Multiple Nucleopolyhedrovirus ac54 Gene Is Crucial for Localization of the Major Capsid Protein VP39 at the Site of Nucleocapsid Assembly."
] | [
1997,
2016
] | 2 | [] | [] | 0 | 0 | null | [
"Baculoviridae"
] | [
141
] | 1 | [] | [] | 0 | true | Family | Baculovirus VP1054 | Baculovirus VP1054 | Baculo_VP1054 | 7 |
IPR008417 | 8,417 | B-cell receptor-associated protein 29/31 | BAP29/BAP31 | Family | 9,246 | false | false | The mammalian B-cell receptor-associated proteins of 29 and 31kDa (BAP29 and BAP31) are integral membrane proteins with a role in endoplasmic reticulum (ER) quality control and sorting [ , , ]. BAP31 is also involved in apoptosis [ ]. Saccharomyces cerevisiae possesses three homologues of BAP31 known as Yet1, Yet2, and... | [
"GO:0006886",
"GO:0005783",
"GO:0016020"
] | [
"intracellular protein transport",
"endoplasmic reticulum",
"membrane"
] | [
"biological_process",
"cellular_component",
"cellular_component"
] | 3 | [
"PANTHER"
] | [
"PTHR12701"
] | [
""
] | [
9246
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-DDI-75153",
"R-HSA-111465",
"R-HSA-75153",
"R-HSA-8980692",
"R-HSA-983170",
"R-HSA-9833110",
"R-MMU-111465",
"R-MMU-75153",
"R-MMU-8980692",
"R-MMU-983170",
"R-SCE-75153",
"R-SPO-75153"
] | [
"REACTOME:R-DDI-75153",
"REACTOME:R-HSA-111465",
"REACTOME:R-HSA-75153",
"REACTOME:R-HSA-8980692",
"REACTOME:R-HSA-983170",
"REACTOME:R-HSA-9833110",
"REACTOME:R-MMU-111465",
"REACTOME:R-MMU-75153",
"REACTOME:R-MMU-8980692",
"REACTOME:R-MMU-983170",
"REACTOME:R-SCE-75153",
"REACTOME:R-SPO-7515... | 12 | [
"4jzl",
"4jzp",
"4w7y",
"4w7z",
"4w80",
"8xwx"
] | 6 | [
"PUB00070154",
"PUB00070155",
"PUB00070156",
"PUB00070157",
"PUB00070159"
] | [
"20378542",
"9396746",
"17056546",
"15187134",
"21183955"
] | [
"Yet1p and Yet3p, the yeast homologs of BAP29 and BAP31, interact with the endoplasmic reticulum translocation apparatus and are required for inositol prototrophy.",
"Export of cellubrevin from the endoplasmic reticulum is controlled by BAP31.",
"Bap31 enhances the endoplasmic reticulum export and quality contr... | [
2010,
1997,
2006,
2004,
2011
] | 5 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Yasminevirus sp. GU-2018",
"bird metagenome"
] | [
9244,
1,
1
] | 3 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
35,
1,
2,
3,
23,
4,
1,
19,
9,
3,
1,
31
] | 12 | true | Family | B-cell receptor-associated protein 29/31 | B-cell receptor-associated protein 29/31 | BAP29/BAP31 | 3 |
IPR008419 | 8,419 | Benyvirus p25/p26 | BNYVV_p25/p26 | Family | 416 | false | false | This entry consists of p25 and p26 proteins from the Beet necrotic yellow vein virus (BNYVV), which is a plant pathogenic virus [ ]. It is characterised by a positive-stranded single stranded RNA genome that is rod-shaped and non-enveloped in nature. The virus is transmitted by Polymyxa betae, a fungus from the order P... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF05744"
] | [
"Benyvirus_P25"
] | [
416
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00043609",
"PUB00076451",
"PUB00076453"
] | [
"16186246",
"23282068",
"18420811"
] | [
"Phylogenetic analysis of isolates of Beet necrotic yellow vein virus collected worldwide.",
"Effect of sugar beet genotype on the Beet necrotic yellow vein virus P25 pathogenicity factor and evidence for a fitness penalty in resistance-breaking strains.",
"Identification of amino acids of the beet necrotic yel... | [
2005,
2013,
2008
] | 3 | [] | [] | 0 | 0 | null | [
"Benyvirus"
] | [
416
] | 1 | [] | [] | 0 | true | Family | Benyvirus p25/p26 | Benyvirus p25/p26 | BNYVV_p25/p26 | 4 |
IPR008420 | 8,420 | Borrelia membrane P13 | Borrelia_P13 | Family | 148 | false | false | Lyme borreliosis (or Lyme's disease) is one of the most common tick-borne diseases. It is caused by bacteria from the genus Borrelia. This family consists of P13 proteins from Borrelia species. P13 is a 13kDa integral membrane protein which is post-translationally processed at both ends and modified by an unknown mecha... | [] | [] | [] | 0 | [
"NCBIFAM",
"PFAM"
] | [
"NF033724",
"PF05628"
] | [
"P13_porin",
"Borrelia_P13"
] | [
114,
148
] | 2 | [] | [] | [] | 0 | [] | 0 | [
"PUB00011267",
"PUB00105272"
] | [
"11292755",
"24825899"
] | [
"P13, an integral membrane protein of Borrelia burgdorferi, is C-terminally processed and contains surface-exposed domains.",
"Study of the protein complex, pore diameter, and pore-forming activity of the Borrelia burgdorferi P13 porin."
] | [
2001,
2014
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria"
] | [
148
] | 1 | [] | [] | 0 | true | Family | Borrelia membrane P13 | Borrelia membrane P13 | Borrelia_P13 | 6 |
IPR008422 | 8,422 | KN homeodomain | KN_HD | Domain | 50,654 | false | false | This entry represents a homeodomain (HD) present in transcription factors conserved from fungi to human and plants [ ]. Genes encoding these proteins were first identified as TALE homeobox proteins in eukaryotes, (including KNOX and MEIS genes) [ , , ]. They have been classified [ , , ]. | [
"GO:0003677",
"GO:0006355"
] | [
"DNA binding",
"regulation of DNA-templated transcription"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PFAM"
] | [
"PF05920"
] | [
"Homeobox_KN"
] | [
50654
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-CEL-2173795",
"R-DME-390193",
"R-HSA-2173795",
"R-HSA-2173796",
"R-HSA-452723",
"R-HSA-5617472",
"R-HSA-9013508",
"R-HSA-9764725",
"R-HSA-9830674",
"R-HSA-9831926",
"R-MMU-2173795"
] | [
"REACTOME:R-CEL-2173795",
"REACTOME:R-DME-390193",
"REACTOME:R-HSA-2173795",
"REACTOME:R-HSA-2173796",
"REACTOME:R-HSA-452723",
"REACTOME:R-HSA-5617472",
"REACTOME:R-HSA-9013508",
"REACTOME:R-HSA-9764725",
"REACTOME:R-HSA-9830674",
"REACTOME:R-HSA-9831926",
"REACTOME:R-MMU-2173795"
] | 11 | [
"1b72",
"1b8i",
"1du6",
"1lfu",
"1puf",
"1x2n",
"2dmn",
"2lk2",
"2r5y",
"2r5z",
"3k2a",
"4cyc",
"4egc",
"4uus",
"4xrm",
"4xrs",
"5bng",
"5eg0",
"5ego",
"5zjq",
"5zjr",
"5zjs",
"5zjt",
"6fqp",
"6fqq",
"7yb4",
"8vts",
"8vtt"
] | 28 | [
"PUB00020003",
"PUB00053798",
"PUB00075494",
"PUB00075495",
"PUB00075496",
"PUB00075497"
] | [
"9336443",
"17429685",
"8537382",
"17665086",
"19734295",
"21557080"
] | [
"Analysis of TALE superclass homeobox genes (MEIS, PBC, KNOX, Iroquois, TGIF) reveals a novel domain conserved between plants and animals.",
"Expression patterns of class I KNOX and YABBY genes in Ruscus aculeatus (Asparagaceae) with implications for phylloclade homology.",
"A novel homeobox protein which recog... | [
1997,
2007,
1995,
2007,
2009,
2011
] | 6 | [
"IPR001356"
] | [] | 1 | 0 | 1 | [
"Eukaryota",
"Parendozoicomonas callyspongiae",
"unclassified Klosneuvirinae"
] | [
50648,
1,
5
] | 3 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
97,
6,
106,
17,
87,
64,
2,
90,
72,
2,
162
] | 11 | true | Domain | KN homeodomain | KN homeodomain | KN_HD | 2 |
IPR008424 | 8,424 | Immunoglobulin C2-set | Ig_C2-set | Domain | 1,299 | false | false | The basic structure of immunoglobulin (Ig) molecules is a tetramer of two light chains and two heavy chains linked by disulphide bonds. There are two types of light chains: kappa and lambda, each composed of a constant domain (CL) and a variable domain (VL). There are five types of heavy chains: alpha, delta, epsilon, ... | [
"GO:0007155",
"GO:0016020"
] | [
"cell adhesion",
"membrane"
] | [
"biological_process",
"cellular_component"
] | 2 | [
"PFAM"
] | [
"PF05790"
] | [
"C2-set"
] | [
1299
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-CFA-202424",
"R-CFA-202427",
"R-CFA-202430",
"R-CFA-202433",
"R-CFA-389948",
"R-CFA-449836",
"R-CFA-8856825",
"R-CFA-8856828",
"R-HSA-1462054",
"R-HSA-167590",
"R-HSA-173107",
"R-HSA-180534",
"R-HSA-198933",
"R-HSA-202424",
"R-HSA-202427",
"R-HSA-202430",
"R-HSA-202433",
"R-HSA-... | [
"REACTOME:R-CFA-202424",
"REACTOME:R-CFA-202427",
"REACTOME:R-CFA-202430",
"REACTOME:R-CFA-202433",
"REACTOME:R-CFA-389948",
"REACTOME:R-CFA-449836",
"REACTOME:R-CFA-8856825",
"REACTOME:R-CFA-8856828",
"REACTOME:R-HSA-1462054",
"REACTOME:R-HSA-167590",
"REACTOME:R-HSA-173107",
"REACTOME:R-HSA-... | 47 | [
"1ccz",
"1cdh",
"1cdi",
"1cdj",
"1cdu",
"1cdy",
"1cid",
"1g9m",
"1g9n",
"1gc1",
"1hnf",
"1hng",
"1ij9",
"1jl4",
"1rzj",
"1rzk",
"1vca",
"1vsc",
"1wio",
"1wip",
"1wiq",
"2b4c",
"2dru",
"2nxy",
"2nxz",
"2ny0",
"2ny1",
"2ny2",
"2ny3",
"2ny4",
"2ny5",
"2ny6"... | 82 | [
"PUB00010610",
"PUB00011269",
"PUB00011270",
"PUB00014840",
"PUB00015110",
"PUB00027654",
"PUB00027656"
] | [
"11377196",
"11376005",
"7907198",
"9417933",
"15327963",
"15326605",
"10698639"
] | [
"Mapping the folding pathway of an immunoglobulin domain: structural detail from Phi value analysis and movement of the transition state.",
"Dynamic recruitment of human CD2 into lipid rafts. Linkage to T cell signal transduction.",
"An African swine fever virus gene with similarity to the T-lymphocyte surface ... | [
2001,
2001,
1994,
1997,
2004,
2004,
2000
] | 7 | [] | [] | 0 | 0 | null | [
"Euteleostomi"
] | [
1299
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
15,
15,
10
] | 3 | true | Domain | Immunoglobulin C2-set | Immunoglobulin C2-set | Ig_C2-set | 8 |
IPR008425 | 8,425 | Cyclin-dependent kinase inhibitor 3 | CDK_inhib_3 | Family | 1,051 | false | false | This family consists of cyclin-dependent kinase inhibitor 3 or kinase associated phosphatase proteins from several mammalian species. The cyclin-dependent kinase (Cdk)-associated protein phosphatase (KAP) is a Homo sapiens dual specificity protein phosphatase that dephosphorylates Cdk2 on threonine 160 in a cyclin-depe... | [
"GO:0004721",
"GO:0004725"
] | [
"phosphoprotein phosphatase activity",
"protein tyrosine phosphatase activity"
] | [
"molecular_function",
"molecular_function"
] | 2 | [
"PIRSF"
] | [
"PIRSF037322"
] | [
"CDKN3"
] | [
1051
] | 1 | [
"EC",
"EC"
] | [
"3.1.3.16",
"3.1.3.48"
] | [
"EC:3.1.3.16",
"EC:3.1.3.48"
] | 2 | [
"1fpz",
"1fq1"
] | 2 | [
"PUB00011549",
"PUB00011550"
] | [
"8127873",
"10987270"
] | [
"KAP: a dual specificity phosphatase that interacts with cyclin-dependent kinases.",
"Aberrant transcripts of the cyclin-dependent kinase-associated protein phosphatase in hepatocellular carcinoma."
] | [
1994,
2000
] | 2 | [] | [] | 0 | 0 | null | [
"Eumetazoa"
] | [
1051
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
11,
1,
3
] | 4 | true | Family | Cyclin-dependent kinase inhibitor 3 | Cyclin-dependent kinase inhibitor 3 | CDK_inhib_3 | 4 |
IPR008426 | 8,426 | Centromere protein H, C-terminal | CENP-H_C | Domain | 1,808 | false | false | Chromosome segregation in eukaryotes requires the kinetochore, a multi-protein structure that assembles on centromeric DNA, and which acts to link chromosomes to spindle microtubules. Kinetochore structure and composition is highly conserved among vertebrates. The inner kinetochore is essential for kinetochore assembly... | [
"GO:0051382",
"GO:0000776"
] | [
"kinetochore assembly",
"kinetochore"
] | [
"biological_process",
"cellular_component"
] | 2 | [
"PFAM"
] | [
"PF05837"
] | [
"CENP-H"
] | [
1808
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-141444",
"R-BTA-2467813",
"R-BTA-2500257",
"R-BTA-5663220",
"R-BTA-606279",
"R-BTA-68877",
"R-BTA-9648025",
"R-GGA-141444",
"R-GGA-2467813",
"R-GGA-2500257",
"R-GGA-5663220",
"R-GGA-606279",
"R-GGA-9648025",
"R-HSA-141444",
"R-HSA-2467813",
"R-HSA-2500257",
"R-HSA-5663220",
... | [
"REACTOME:R-BTA-141444",
"REACTOME:R-BTA-2467813",
"REACTOME:R-BTA-2500257",
"REACTOME:R-BTA-5663220",
"REACTOME:R-BTA-606279",
"REACTOME:R-BTA-68877",
"REACTOME:R-BTA-9648025",
"REACTOME:R-GGA-141444",
"REACTOME:R-GGA-2467813",
"REACTOME:R-GGA-2500257",
"REACTOME:R-GGA-5663220",
"REACTOME:R-G... | 27 | [
"5z08",
"7pb4",
"7pkn",
"7qoo",
"7r5s",
"7r5v",
"7xhn",
"7xho",
"7ywx",
"7yyh"
] | 10 | [
"PUB00011271",
"PUB00044193",
"PUB00044860",
"PUB00044861",
"PUB00044863",
"PUB00044864"
] | [
"10488063",
"16079914",
"16622420",
"18094054",
"18700042",
"17255272"
] | [
"Characterization of a novel kinetochore protein, CENP-H.",
"Molecular analysis of kinetochore architecture in fission yeast.",
"The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres.",
"CENP-O class proteins form a stable complex and are required for pr... | [
1999,
2005,
2006,
2008,
2008,
2007
] | 6 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1808
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
1,
4,
1,
1,
7,
1
] | 6 | true | Domain | Centromere protein H, C-terminal | Centromere protein H, C-terminal | CENP-H_C | 1 |
IPR008427 | 8,427 | Extracellular membrane protein, CFEM domain | Extracellular_membr_CFEM_dom | Domain | 16,346 | false | false | The CFEM domain is a fungal-specific domain that contains eight cysteines and is found in some proteins with proposed roles in fungal pathogenesis [ ]. The structure of the CFEM domain containing protein 'Surface antigen protein 2' from Candida albicans ( ) has been solved [ ]. The CFEM (Common in Fungal Extracellular ... | [] | [] | [] | 0 | [
"PFAM",
"PROFILE",
"SMART"
] | [
"PF05730",
"PS52012",
"SM00747"
] | [
"CFEM",
"CFEM",
"CFEM"
] | [
15864,
12648,
8949
] | 3 | [] | [] | [] | 0 | [
"4y7s"
] | 1 | [
"PUB00011272",
"PUB00082834",
"PUB00153266",
"PUB00153267"
] | [
"12633989",
"27617569",
"34682292",
"35523457"
] | [
"An eight-cysteine-containing CFEM domain unique to a group of fungal membrane proteins.",
"Structural basis of haem-iron acquisition by fungal pathogens.",
"Bioinformatics and Transcriptome Analysis of CFEM Proteins in Fusarium graminearum.",
"Systematic contributions of CFEM domain-containing proteins to ir... | [
2003,
2016,
2021,
2022
] | 4 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
16346
] | 1 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Zea mays"
] | [
15,
1,
1
] | 3 | true | Domain | Extracellular membrane protein, CFEM domain | Extracellular membrane protein, CFEM domain | Extracellular_membr_CFEM_dom | 2 |
IPR008429 | 8,429 | Cleft lip and palate transmembrane 1 | CLPTM1 | Family | 7,779 | false | false | This entry includes cleft lip and palate transmembrane protein 1 (CLPTM1) and cleft lip and palate transmembrane protein 1-like protein (CLPTM1L, also known as CRR9). This entry also includes uncharacterised proteins from fungi and plants. Clefts of the lip and/or palate (CL/P) are some of the most common birth defects... | [
"GO:0016020"
] | [
"membrane"
] | [
"cellular_component"
] | 1 | [
"PFAM",
"PANTHER"
] | [
"PF05602",
"PTHR21347"
] | [
"CLPTM1",
""
] | [
7548,
7643
] | 2 | [] | [] | [] | 0 | [] | 0 | [
"PUB00011273",
"PUB00053840",
"PUB00053841",
"PUB00053842",
"PUB00072648",
"PUB00072649",
"PUB00101083"
] | [
"9828125",
"16122939",
"11559849",
"19715471",
"24366883",
"22675468",
"35344438"
] | [
"Characterization of a novel gene disrupted by a balanced chromosomal translocation t(2;19)(q11.2;q13.3) in a family with cleft lip and palate.",
"Mutation analysis of CLPTM 1 and PVRL 1 genes in patients with non-syndromic clefts of lip, alveolus and palate.",
"Mutation of PVRL1 is associated with sporadic, no... | [
1998,
2005,
2001,
2009,
2014,
2012,
2022
] | 7 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"bird metagenome"
] | [
7777,
2
] | 2 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
15,
3,
3,
2,
9,
2,
1,
6,
5,
14
] | 10 | true | Family | Cleft lip and palate transmembrane 1 | Cleft lip and palate transmembrane 1 | CLPTM1 | 1 |
IPR008430 | 8,430 | Cytotoxic necrotizing factor, Rho-activating domain | CNF_Rho-act | Domain | 152 | false | false | This domain is found in several bacterial cytotoxic necrotizing factor proteins as well as related dermonecrotic toxin (DNT) from Bordetella species [ ]. Cytotoxic necrotizing factor 1 (CNF1) is a toxin whose structure from Escherichia coli revealed a 4-layer α/β/β/α structure containing mixed β-sheets [ ]. CNF1 is exp... | [] | [] | [] | 0 | [
"PFAM",
"CDD"
] | [
"PF05785",
"cd16834"
] | [
"CNF1",
"CNF1-like"
] | [
152,
136
] | 2 | [] | [] | [] | 0 | [
"1hq0",
"1hzg",
"6yhk",
"6yhm",
"6yhn"
] | 5 | [
"PUB00011275",
"PUB00011276",
"PUB00019322"
] | [
"12622819",
"12065482",
"11427886"
] | [
"Expression of cnf1 by Escherichia coli J96 involves a large upstream DNA region including the hlyCABD operon, and is regulated by the RfaH protein.",
"Identification of a receptor-binding domain of Bordetella dermonecrotic toxin.",
"Structure of the Rho-activating domain of Escherichia coli cytotoxic necrotizi... | [
2003,
2002,
2001
] | 3 | [] | [] | 0 | 0 | null | [
"Pseudomonadota"
] | [
152
] | 1 | [] | [] | 0 | true | Domain | Cytotoxic necrotizing factor, Rho-activating domain | Cytotoxic necrotizing factor, Rho-activating domain | CNF_Rho-act | 3 |
IPR008431 | 8,431 | Cyclic nucleotide phosphodiesterase | CNPase | Family | 1,424 | false | false | This entry includes the eukaryotic protein 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNPase) [ ]. CNPase is one of the earliest myelin-related proteins expressed in differentiating oligodendrocytes and Schwann cells. CNPase is abundant in the central nervous system and in oligodendrocytes [ ]. This protein is also ... | [
"GO:0004113",
"GO:0009214",
"GO:0016020"
] | [
"2',3'-cyclic-nucleotide 3'-phosphodiesterase activity",
"cyclic nucleotide catabolic process",
"membrane"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PIRSF",
"PANTHER"
] | [
"PIRSF000970",
"PTHR10156"
] | [
"CNPase",
""
] | [
608,
1424
] | 2 | [
"EC"
] | [
"3.1.4.37"
] | [
"EC:3.1.4.37"
] | 1 | [
"1woj",
"2i3e",
"2ilx",
"2xmi",
"2y1p",
"2y3x",
"2ydb",
"2ydc",
"2ydd",
"2yoz",
"2yp0",
"2ypc",
"2ype",
"2yph",
"2yq9",
"3zbr",
"3zbs",
"3zbz",
"4wbi",
"4wbl",
"4wc9",
"4wca",
"4wcb",
"4wcc",
"4wda",
"4wdb",
"4wdd",
"4wde",
"4wdf",
"4wdg",
"4wdh",
"4wex"... | 41 | [
"PUB00011277",
"PUB00059794",
"PUB00083499"
] | [
"11885989",
"22393399",
"26563764"
] | [
"Assignment of the 1H, 13C and 15N resonances of the catalytic domain of the rat 2',3'-cyclic nucleotide 3'-phosphodiesterase.",
"Myelin 2',3'-cyclic nucleotide 3'-phosphodiesterase: active-site ligand binding and molecular conformation.",
"Determinants of ligand binding and catalytic activity in the myelin enz... | [
2002,
2012,
2015
] | 3 | [] | [] | 0 | 0 | null | [
"Acidipropionibacterium virtanenii",
"Caudoviricetes",
"Eukaryota"
] | [
1,
22,
1401
] | 3 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
13,
7,
4,
4
] | 4 | true | Family | Cyclic nucleotide phosphodiesterase | Cyclic nucleotide phosphodiesterase | CNPase | 1 |
IPR008432 | 8,432 | Cytochrome c oxidase subunit 5c | COX5C | Family | 885 | false | false | COX5C is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport [ ]. | [] | [] | [] | 0 | [
"PIRSF",
"PANTHER"
] | [
"PIRSF038131",
"PTHR34372"
] | [
"COX5C",
""
] | [
380,
885
] | 2 | [] | [] | [] | 0 | [
"7jro",
"7jrp"
] | 2 | [
"PUB00077129"
] | [
"8025826"
] | [
"The nuclear gene for subunit Vc of sweet potato cytochrome c oxidase."
] | [
1993
] | 1 | [] | [] | 0 | 0 | null | [
"Viridiplantae"
] | [
885
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
11,
1,
5
] | 3 | true | Family | Cytochrome c oxidase subunit 5c | Cytochrome c oxidase subunit 5c | COX5C | 5 |
IPR008433 | 8,433 | Cytochrome C oxidase, subunit VIIB | Cyt_c_oxidase_suVIIB | Family | 1,146 | false | false | Cytochrome oxidase subunit VIIB is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport [ ]. The X-ray structure of azide-bound fully oxidized cytochrome c oxidase from bovine heart at 2.9 A resolution has been determined [ ]. | [
"GO:0006123"
] | [
"mitochondrial electron transport, cytochrome c to oxygen"
] | [
"biological_process"
] | 1 | [
"PFAM",
"PANTHER",
"CDD"
] | [
"PF05392",
"PTHR16716",
"cd01403"
] | [
"COX7B",
"",
"Cyt_c_Oxidase_VIIb"
] | [
1146,
1125,
306
] | 3 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-5628897",
"R-HSA-611105",
"R-HSA-9707564",
"R-HSA-9864848",
"R-MMU-5628897",
"R-MMU-611105",
"R-MMU-9707564",
"R-MMU-9864848",
"R-RNO-5628897",
"R-RNO-611105",
"R-RNO-9707564",
"R-RNO-9864848"
] | [
"REACTOME:R-HSA-5628897",
"REACTOME:R-HSA-611105",
"REACTOME:R-HSA-9707564",
"REACTOME:R-HSA-9864848",
"REACTOME:R-MMU-5628897",
"REACTOME:R-MMU-611105",
"REACTOME:R-MMU-9707564",
"REACTOME:R-MMU-9864848",
"REACTOME:R-RNO-5628897",
"REACTOME:R-RNO-611105",
"REACTOME:R-RNO-9707564",
"REACTOME:R... | 12 | [
"1occ",
"1oco",
"1ocr",
"1ocz",
"1v54",
"1v55",
"2dyr",
"2dys",
"2eij",
"2eik",
"2eil",
"2eim",
"2ein",
"2occ",
"2y69",
"2ybb",
"2zxw",
"3abk",
"3abl",
"3abm",
"3ag1",
"3ag2",
"3ag3",
"3ag4",
"3asn",
"3aso",
"3wg7",
"3x2q",
"5b1a",
"5b1b",
"5b3s",
"5gpn"... | 109 | [
"PUB00011542",
"PUB00097156"
] | [
"10771420",
"28870773"
] | [
"X-ray structure of azide-bound fully oxidized cytochrome c oxidase from bovine heart at 2.9 A resolution.",
"Mitochondrial cytochrome c oxidase biogenesis: Recent developments."
] | [
2000,
2018
] | 2 | [] | [] | 0 | 0 | null | [
"Vertebrata"
] | [
1146
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
6,
3,
5
] | 4 | true | Family | Cytochrome C oxidase, subunit VIIB | Cytochrome C oxidase, subunit VIIB | Cyt_c_oxidase_suVIIB | 9 |
IPR008434 | 8,434 | Magnesium-protoporphyrin IX monomethyl ester [oxidative] cyclase | AcsF | Family | 3,155 | false | false | This family represents the oxidative cyclase responsible for forming the distinctive E-ring of the chlorin ring system under aerobic conditions [ ]. This enzyme is believed to utilise a binuclear iron centre and molecular oxygen. There are two isoforms of this enzyme in some plants and cyanobacteria, which are differen... | [
"GO:0046872",
"GO:0048529",
"GO:0015979",
"GO:0015995"
] | [
"metal ion binding",
"magnesium-protoporphyrin IX monomethyl ester (oxidative) cyclase activity",
"photosynthesis",
"chlorophyll biosynthetic process"
] | [
"molecular_function",
"molecular_function",
"biological_process",
"biological_process"
] | 4 | [
"HAMAP",
"NCBIFAM",
"PANTHER",
"NCBIFAM",
"CDD"
] | [
"MF_01840",
"NF010172",
"PTHR31053",
"TIGR02029",
"cd01047"
] | [
"AcsF",
"PRK13654.1",
"",
"AcsF",
"ACSF"
] | [
2237,
2243,
3155,
2364,
2101
] | 5 | [
"EC",
"GP"
] | [
"1.14.13.81",
"GenProp0144"
] | [
"EC:1.14.13.81",
"GP:GenProp0144"
] | 2 | [] | 0 | [
"PUB00011279",
"PUB00015567",
"PUB00015568"
] | [
"11790744",
"10811605",
"11910013"
] | [
"Rubrivivax gelatinosus acsF (previously orf358) codes for a conserved, putative binuclear-iron-cluster-containing protein involved in aerobic oxidative cyclization of Mg-protoporphyrin IX monomethylester.",
"The Crd1 gene encodes a putative di-iron enzyme required for photosystem I accumulation in copper deficie... | [
2002,
2000,
2002
] | 3 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"freshwater sediment metagenome"
] | [
1232,
1922,
1
] | 3 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
3,
4,
6
] | 3 | true | Family | Magnesium-protoporphyrin IX monomethyl ester [oxidative] cyclase | Magnesium-protoporphyrin IX monomethyl ester [oxidative] cyclase | AcsF | 9 |
IPR008435 | 8,435 | Corticotropin-releasing factor-binding protein | CRF-bd | Family | 1,515 | false | false | This family consists of several eukaryotic corticotropin-releasing factor binding proteins (CRF-BP or CRH-BP). Corticotropin-releasing hormone (CRH) plays multiple roles in vertebrate species. In mammals, it is the major hypothalamic releasing factor for pituitary adrenocorticotropin secretion, and is a neurotransmitte... | [
"GO:0051424"
] | [
"corticotropin-releasing hormone binding"
] | [
"molecular_function"
] | 1 | [
"PIRSF",
"PANTHER"
] | [
"PIRSF009279",
"PTHR10278"
] | [
"CRF_bd",
""
] | [
859,
1515
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-373080",
"R-MMU-373080",
"R-RNO-373080"
] | [
"REACTOME:R-HSA-373080",
"REACTOME:R-MMU-373080",
"REACTOME:R-RNO-373080"
] | 3 | [] | 0 | [
"PUB00011280"
] | [
"12379493"
] | [
"Corticotropin-releasing hormone-binding protein: biochemistry and function from fishes to mammals."
] | [
2002
] | 1 | [] | [] | 0 | 0 | null | [
"Bilateria"
] | [
1515
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
2,
2,
4,
3
] | 5 | true | Family | Corticotropin-releasing factor-binding protein | Corticotropin-releasing factor-binding protein | CRF-bd | 1 |
IPR008436 | 8,436 | Sulfur-rich protein | SRP-like | Family | 43 | false | false | Chlamydia is a genus of bacteria, which causes the most common bacterial sexually transmitted diseases. They are obligate intracellular bacterial pathogens. Members of this genus lack a peptidoglycan layer, but as a substitute, it has been proposed that they have several cysteine rich membrane proteins. This includes t... | [
"GO:0019867"
] | [
"outer membrane"
] | [
"cellular_component"
] | 1 | [
"PFAM"
] | [
"PF05745"
] | [
"CRPA"
] | [
43
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00011281",
"PUB00044585",
"PUB00044586"
] | [
"3066701",
"15835913",
"17601785"
] | [
"Molecular cloning and sequence analysis of a developmentally regulated cysteine-rich outer membrane protein from Chlamydia trachomatis.",
"Characterization of the disulfide bonds and free cysteine residues of the Chlamydia trachomatis mouse pneumonitis major outer membrane protein.",
"Structural and functional... | [
1988,
2005,
2007
] | 3 | [] | [] | 0 | 0 | null | [
"Bacteria"
] | [
43
] | 1 | [] | [] | 0 | true | Family | Sulfur-rich protein | Sulfur-rich protein | SRP-like | 4 |
IPR008437 | 8,437 | Minor structural protein VP2, calicivirus | Minor_structural_calicivir | Family | 307 | false | false | This family consists of minor structural proteins largely from the Caliciviridaei family of viruses, including Sapporo virus (Hu/Chiba/041413/2004/JP) and Sapporo virus (Hu/Ehime/04-1680/2004/JP). These viruses cause gastroenteritis. This protein may form a portal-like structure at a unique three-fold axis of symmetry,... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF05752"
] | [
"Calici_MSP"
] | [
307
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Caliciviridae"
] | [
307
] | 1 | [] | [] | 0 | true | Family | Minor structural protein VP2, calicivirus | Minor structural protein VP2, calicivirus | Minor_structural_calicivir | 5 |
IPR008439 | 8,439 | Campylobacter major outer membrane | Campylo_MOMP | Family | 872 | false | false | Campylobacter are Gram-negative, spiral, microaerophilic bacteria. Campylobacter jejuni is one of the main causative agents of food poisoning in the developed world. This family consists of Campylobacter major outer membrane proteins. The major outer membrane protein (MOMP), a putative porin and a multifunction surface... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF05538"
] | [
"Campylo_MOMP"
] | [
872
] | 1 | [] | [] | [] | 0 | [
"5ldt",
"5ldv"
] | 2 | [
"PUB00011289"
] | [
"10992471"
] | [
"Sequence polymorphism, predicted secondary structures, and surface-exposed conformational epitopes of Campylobacter major outer membrane protein."
] | [
2000
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"ecological metagenomes"
] | [
870,
2
] | 2 | [] | [] | 0 | true | Family | Campylobacter major outer membrane | Campylobacter major outer membrane | Campylo_MOMP | 8 |
IPR008440 | 8,440 | Agglutinin-like protein repeat | Agglutinin-like_ALS_rpt | Repeat | 644 | false | false | Adhesive properties in fungi are conveyed by a group of cell-surface proteins called adhesins (sometimes also referred to as agglutinins or flocculins). Several fungal adhesins have been described to date, including the the Candida albicans Als (agglutinin-like sequence) proteins [ ]. Als proteins are cell-surface glyc... | [
"GO:0007155"
] | [
"cell adhesion"
] | [
"biological_process"
] | 1 | [
"PFAM"
] | [
"PF05792"
] | [
"Candida_ALS"
] | [
644
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00011290",
"PUB00045059"
] | [
"11124701",
"17870620"
] | [
"The ALS5 gene of Candida albicans and analysis of the Als5p N-terminal domain.",
"Molecular phylogenetics of ascomycotal adhesins--a novel family of putative cell-surface adhesive proteins in fission yeasts."
] | [
2001,
2008
] | 2 | [] | [] | 0 | 0 | null | [
"Dikarya"
] | [
644
] | 1 | [] | [] | 0 | true | Repeat | Agglutinin-like protein repeat | Agglutinin-like protein repeat | Agglutinin-like_ALS_rpt | 1 |
IPR008441 | 8,441 | AfumC-like glycosyltransferase | AfumC-like_glycosyl_Trfase | Family | 2,965 | false | false | This entry includes several O-glycosyltransferases from the afumC family. afumC from Aspergillus fumigatus is part of the gene cluster that mediates the biosynthesis fumihopaside A, a hopane-type glucoside that enhances the thermotolerance and UV resistance [ ]. PaGT from the yeast Phomopsis amygdali is important for t... | [
"GO:0016757"
] | [
"glycosyltransferase activity"
] | [
"molecular_function"
] | 1 | [
"PFAM"
] | [
"PF05704"
] | [
"Caps_synth"
] | [
2965
] | 1 | [
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC"... | [
"2.4.1.-",
"PWY-1901",
"PWY-1961",
"PWY-1981",
"PWY-2021",
"PWY-2881",
"PWY-2901",
"PWY-2902",
"PWY-4421",
"PWY-4801",
"PWY-5094",
"PWY-5105",
"PWY-5129",
"PWY-5139",
"PWY-5160",
"PWY-5161",
"PWY-5268",
"PWY-5284",
"PWY-5286",
"PWY-5310",
"PWY-5312",
"PWY-5313",
"PWY-5317... | [
"EC:2.4.1.-",
"METACYC:PWY-1901",
"METACYC:PWY-1961",
"METACYC:PWY-1981",
"METACYC:PWY-2021",
"METACYC:PWY-2881",
"METACYC:PWY-2901",
"METACYC:PWY-2902",
"METACYC:PWY-4421",
"METACYC:PWY-4801",
"METACYC:PWY-5094",
"METACYC:PWY-5105",
"METACYC:PWY-5129",
"METACYC:PWY-5139",
"METACYC:PWY-5... | 200 | [] | 0 | [
"PUB00011291",
"PUB00090984",
"PUB00097904",
"PUB00097905"
] | [
"11179285",
"22870285",
"30977375",
"28802024"
] | [
"Molecular characterization of Streptococcus pneumoniae type 4, 6B, 8, and 18C capsular polysaccharide gene clusters.",
"Molecular breeding of a fungus producing a precursor diterpene suitable for semi-synthesis by dissection of the biosynthetic machinery.",
"Characterization and Biosynthesis of a Rare Fungal H... | [
2001,
2012,
2019,
2018
] | 4 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Methanobacteriota",
"Viruses",
"metagenomes"
] | [
1487,
1358,
3,
47,
70
] | 5 | [] | [] | 0 | true | Family | AfumC-like glycosyltransferase | AfumC-like glycosyltransferase | AfumC-like_glycosyl_Trfase | 6 |
IPR008442 | 8,442 | Propeptide, carboxypeptidase Y | Propeptide_carboxypepY | Domain | 1,118 | false | false | This signature is found at the N terminus of carboxypeptidase Y, which belong to MEROPS peptidase family S10. This region contains the signal peptide and pro-peptide regions [ , ]. | [
"GO:0004185",
"GO:0005773"
] | [
"serine-type carboxypeptidase activity",
"vacuole"
] | [
"molecular_function",
"cellular_component"
] | 2 | [
"PFAM"
] | [
"PF05388"
] | [
"Carbpep_Y_N"
] | [
1118
] | 1 | [
"EC"
] | [
"3.4.16.5"
] | [
"EC:3.4.16.5"
] | 1 | [] | 0 | [
"PUB00011553",
"PUB00011554"
] | [
"8789258",
"10077185"
] | [
"Cloning and characterization of the Pichia pastoris PRC1 gene encoding carboxypeptidase Y.",
"Characterization of the Hansenula polymorpha CPY gene encoding carboxypeptidase Y."
] | [
1996,
1999
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteroides nordii",
"Eukaryota",
"marine sediment metagenome"
] | [
2,
1115,
1
] | 3 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)"
] | [
1,
1
] | 2 | true | Domain | Propeptide, carboxypeptidase Y | Propeptide, carboxypeptidase Y | Propeptide_carboxypepY | 2 |
IPR008444 | 8,444 | Chlamydia virulence plasmid protein pGP3 | Chlamydia_pGP3 | Family | 18 | false | false | This family consists of Chlamydia virulence proteins which are thought to be required for the growth of these bacteria in mammalian cells [ ]. Humans mount a humoral and mucosal immune response to plasmid protein pGP3 from Chlamydia trachomatis infections [ , ]. This immune response to pGP3 in humans and animal models ... | [] | [] | [] | 0 | [
"PIRSF"
] | [
"PIRSF016070"
] | [
"Chlamydia_vir"
] | [
18
] | 1 | [] | [] | [] | 0 | [
"4jdm",
"6gjt"
] | 2 | [
"PUB00011294",
"PUB00044587",
"PUB00044588",
"PUB00044589"
] | [
"2845228",
"7960130",
"12559784",
"12780690"
] | [
"The structure of a plasmid of Chlamydia trachomatis believed to be required for growth within mammalian cells.",
"Humoral immune response to plasmid protein pgp3 in patients with Chlamydia trachomatis infection.",
"DNA immunization with pgp3 gene of Chlamydia trachomatis inhibits the spread of chlamydial infec... | [
1988,
1994,
2003,
2003
] | 4 | [] | [] | 0 | 0 | null | [
"Chlamydia"
] | [
18
] | 1 | [] | [] | 0 | true | Family | Chlamydia virulence plasmid protein pGP3 | Chlamydia virulence plasmid protein pGP3 | Chlamydia_pGP3 | 4 |
IPR008445 | 8,445 | Core protein A15 | A15 | Family | 93 | false | false | This entry represents Protein A15 from Variola virus, also known as Core protein OPG142, and similar sequences from poxvirus. A15 is a late protein which is a part of a large complex required for early virion morphogenesis. This complex participates in the formation of virosomes and the incorporation of virosomal conte... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF05846"
] | [
"Chordopox_A15"
] | [
93
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00078900"
] | [
"15567438"
] | [
"A complex of seven vaccinia virus proteins conserved in all chordopoxviruses is required for the association of membranes and viroplasm to form immature virions."
] | [
2004
] | 1 | [] | [] | 0 | 0 | null | [
"Poxviridae"
] | [
93
] | 1 | [] | [] | 0 | true | Family | Core protein A15 | Core protein A15 | A15 | 6 |
IPR008447 | 8,447 | Protein L2 | Prot_L2 | Family | 113 | false | false | This entry represents Protein L2 from Vaccinia virus, also known as Protein OPG096, and similar sequences from poxvirus. L2 is involved in early virion morphogenesis. It is required for the formation or elongation of crescent-shaped membrane precursors of immature virions in cytoplasmic factories [ , ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF05803"
] | [
"Chordopox_L2"
] | [
113
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00074860",
"PUB00103643"
] | [
"21228235",
"34730390"
] | [
"Participation of vaccinia virus l2 protein in the formation of crescent membranes and immature virions.",
"Structure-Function Analysis of Two Interacting Vaccinia Proteins That Are Critical for Viral Morphogenesis: L2 and A30.5."
] | [
2011,
2022
] | 2 | [] | [] | 0 | 0 | null | [
"Poxviridae"
] | [
113
] | 1 | [] | [] | 0 | true | Family | Protein L2 | Protein L2 | Prot_L2 | 1 |
IPR008448 | 8,448 | DNA-directed RNA polymerase, 7kDa polypeptide, chordopoxviral | RNA_pol_7kDa_chordopoxvir | Family | 92 | false | false | DNA-directed RNA polymerases (also known as DNA-dependent RNA polymerases) are responsible for the polymerisation of ribonucleotides into a sequence complementary to the template DNA. In eukaryotes, there are three different forms of DNA-directed RNA polymerases transcribing different sets of genes. Most RNA polymerase... | [
"GO:0003677",
"GO:0003899",
"GO:0006351"
] | [
"DNA binding",
"DNA-directed RNA polymerase activity",
"DNA-templated transcription"
] | [
"molecular_function",
"molecular_function",
"biological_process"
] | 3 | [
"PFAM"
] | [
"PF05864"
] | [
"Chordopox_RPO7"
] | [
92
] | 1 | [
"EC"
] | [
"2.7.7.6"
] | [
"EC:2.7.7.6"
] | 1 | [
"6rfl",
"6ric",
"6rid",
"6rie",
"7amv",
"7aof",
"7aoh",
"7aoz",
"7ap8",
"7ap9",
"8c8h",
"8p0j",
"8p0k",
"8p0n",
"8rqk",
"9ex9",
"9fpy",
"9fq6"
] | 18 | [
"PUB00000061",
"PUB00011555",
"PUB00033173"
] | [
"3052291",
"1560534",
"10499798"
] | [
"Structure and function of bacterial sigma factors.",
"Characterization of a 7-kilodalton subunit of vaccinia virus DNA-dependent RNA polymerase with structural similarities to the smallest subunit of eukaryotic RNA polymerase II.",
"Crystal structure of Thermus aquaticus core RNA polymerase at 3.3 A resolution... | [
1988,
1992,
1999
] | 3 | [] | [] | 0 | 0 | null | [
"Poxviridae"
] | [
92
] | 1 | [] | [] | 0 | true | Family | DNA-directed RNA polymerase, 7kDa polypeptide, chordopoxviral | DNA-directed RNA polymerase, 7kDa polypeptide, chordopoxviral | RNA_pol_7kDa_chordopoxvir | 7 |
IPR008449 | 8,449 | Chorion S36/S38 | Chorion_S36/S28 | Family | 134 | false | false | This family consists Drosophila chorion proteins S36 and S38, which are involved in chorion membrane formation. The proteins consist of a central domain and two flanking 'arms'. The central domain contains tandemly repetitive peptides, which apparently generate a secondary structure of β-sheet strands alternating with ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF05387"
] | [
"Chorion_3"
] | [
134
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00055599"
] | [
"2489096"
] | [
"Structural and functional features of Drosophila chorion proteins s36 and s38 from analysis of primary structure and infrared spectroscopy."
] | [
1989
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Pseudomonadota"
] | [
131,
3
] | 2 | [
"Drosophila melanogaster"
] | [
6
] | 1 | true | Family | Chorion S36/S38 | Chorion S36/S38 | Chorion_S36/S28 | 2 |
IPR008450 | 8,450 | Chorion S16 | Chorion_S16 | Family | 58 | false | false | Correct eggshell formation relies on a complex series of events that relies on expression, cleavage and transport of various proteins at appropriate times. In Drosophila, the eggshell framework is laid down between the developing oocyte and the overlying follicle cells during late oogenesis. Five distinct layers are ob... | [
"GO:0007275",
"GO:0042600"
] | [
"multicellular organism development",
"egg chorion"
] | [
"biological_process",
"cellular_component"
] | 2 | [
"PFAM"
] | [
"PF05836"
] | [
"Chorion_S16"
] | [
58
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00008483",
"PUB00053849"
] | [
"1908228",
"18651659"
] | [
"Drosophila chorion genes: cracking the eggshell's secrets.",
"Building up the Drosophila eggshell: first of all the eggshell genes must be transcribed."
] | [
1991,
2008
] | 2 | [] | [] | 0 | 0 | null | [
"Schizophora"
] | [
58
] | 1 | [
"Drosophila melanogaster"
] | [
3
] | 1 | true | Family | Chorion S16 | Chorion S16 | Chorion_S16 | 7 |
IPR008451 | 8,451 | Chromadorea ALT | Chromadorea_ALT | Family | 196 | false | false | This family consists of several ALT protein homologues found in nematodes. Lymphatic filariasis is a major tropical disease caused by the mosquito borne nematodes Brugia and Wuchereria. About 120 million people are infected and at risk of lymphatic pathology such as acute lymphangitis and elephantiasis. Expression of a... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF05535"
] | [
"Chromadorea_ALT"
] | [
196
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00011296"
] | [
"10858234"
] | [
"The abundant larval transcript-1 and -2 genes of Brugia malayi encode stage-specific candidate vaccine antigens for filariasis."
] | [
2000
] | 1 | [] | [] | 0 | 0 | null | [
"Nematoda"
] | [
196
] | 1 | [
"Caenorhabditis elegans"
] | [
1
] | 1 | true | Family | Chromadorea ALT | Chromadorea ALT | Chromadorea_ALT | 9 |
IPR008452 | 8,452 | Citrus tristeza virus P18 | CTV_P18 | Family | 171 | false | false | This family contains the P18 proteins of citrus tristeza virus (CTV). CTV is a member of the closterovirus group and is one of the more complex single-stranded RNA viruses. Assembly of the viral genome into virions is a critical process of the virus life cycle often defining the ability of the virus to move within the ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF05520"
] | [
"Citrus_P18"
] | [
171
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00011543"
] | [
"11112500"
] | [
"Closterovirus encoded HSP70 homolog and p61 in addition to both coat proteins function in efficient virion assembly."
] | [
2000
] | 1 | [] | [] | 0 | 0 | null | [
"Citrus tristeza virus"
] | [
171
] | 1 | [] | [] | 0 | true | Family | Citrus tristeza virus P18 | Citrus tristeza virus P18 | CTV_P18 | 2 |
IPR008453 | 8,453 | Clavanin | Clavanin | Family | 6 | false | false | This family consists of clavanin proteins from the haemocytes of the invertebrate Styela clava (Sea squirt), a solitary tunicate. The family is made up of five α-helical antimicrobial peptides, clavanins A, B, C, D and E and Clavaspirin. The tunicate peptides resemble magainins in size, primary sequence and antibacteri... | [
"GO:0005576"
] | [
"extracellular region"
] | [
"cellular_component"
] | 1 | [
"PFAM"
] | [
"PF05452"
] | [
"Clavanin"
] | [
6
] | 1 | [] | [] | [] | 0 | [
"6c41"
] | 1 | [
"PUB00011297",
"PUB00161648"
] | [
"9001389",
"12005415"
] | [
"Clavanins, alpha-helical antimicrobial peptides from tunicate hemocytes.",
"Clavaspirin, an antibacterial and haemolytic peptide from Styela clava."
] | [
1997,
2001
] | 2 | [] | [] | 0 | 0 | null | [
"Styela clava"
] | [
6
] | 1 | [] | [] | 0 | true | Family | Clavanin | Clavanin | Clavanin | 8 |
IPR008454 | 8,454 | Collagen-binding surface protein Cna-like, B-type domain | Collagen-bd_Cna-like_B-typ_dom | Domain | 3,354 | false | false | This entry represents a repeated B region domain found in the collagen-binding surface protein Cna in Staphylococcus aureus, as well as other related domains. Cna has a non-repetitive, collagen-binding A region , followed by instances of this B region repetitive unit. The B region has one to four 23kDa repeat units (B1... | [] | [] | [] | 0 | [
"PFAM",
"CDD"
] | [
"PF05738",
"cd00222"
] | [
"Cna_B",
"CollagenBindB"
] | [
3308,
2860
] | 2 | [] | [] | [] | 0 | [
"1d2o",
"1d2p",
"6m3y",
"6m48"
] | 4 | [
"PUB00011298",
"PUB00081232",
"PUB00081233"
] | [
"10673425",
"12700253",
"10036727"
] | [
"Novel fold and assembly of the repetitive B region of the Staphylococcus aureus collagen-binding surface protein.",
"Adhesive surface proteins of Erysipelothrix rhusiopathiae bind to polystyrene, fibronectin, and type I and IV collagens.",
"Surface protein adhesins of Staphylococcus aureus."
] | [
2000,
2003,
1998
] | 3 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Methanobacteriota",
"Phage Phass-1",
"unclassified sequences"
] | [
3330,
9,
2,
13
] | 4 | [] | [] | 0 | true | Domain | Collagen-binding surface protein Cna-like, B-type domain | Collagen-binding surface protein Cna-like, B-type domain | Collagen-bd_Cna-like_B-typ_dom | 3 |
IPR008455 | 8,455 | HssA/B family related | HssA/B-related | Family | 192 | false | false | This entry include a group of Dictyostelium discoideum (Slime mould) proteins, including hssA/B proteins. HssA (also known as NK20) is a high-glycine-serine-rich small protein (8.37kDa), which has strong homology to previously reported cyclic-adenosine-monophosphate-inducible 2C and 7E proteins [ ]. This protein may fo... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF05710"
] | [
"Coiled"
] | [
192
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00011299",
"PUB00075375",
"PUB00090981"
] | [
"2157129",
"18204858",
"30029002"
] | [
"Two cyclic AMP-regulated genes from Dictyostelium discoideum encode homologous proteins.",
"GBF-dependent family genes morphologically suppress the partially active Dictyostelium STATa strain.",
"SRCP1 Conveys Resistance to Polyglutamine Aggregation."
] | [
1990,
2008,
2018
] | 3 | [] | [] | 0 | 0 | null | [
"Dictyostelia",
"Maribacter vaceletii"
] | [
191,
1
] | 2 | [] | [] | 0 | true | Family | HssA/B family related | HssA/B family related | HssA/B-related | 1 |
IPR008456 | 8,456 | Collagen binding domain | Collagen-bd_dom | Domain | 3,126 | false | false | The domain fold is a jelly-roll, composed of two antiparallel β-sheets and two short α-helices [ ]. A groove on β-sheet I exhibited the best surface complementarity to the collagen. This site partially overlaps with the peptide sequence previously shown to be critical for collagen binding. Recombinant proteins containi... | [
"GO:0005518"
] | [
"collagen binding"
] | [
"molecular_function"
] | 1 | [
"PFAM"
] | [
"PF05737"
] | [
"Collagen_bind"
] | [
3126
] | 1 | [] | [] | [] | 0 | [
"1amx",
"2f68",
"2f6a",
"2okm",
"2z1p",
"3v10",
"7lgr",
"8gsx",
"8jl8"
] | 9 | [
"PUB00011300"
] | [
"9334749"
] | [
"Structure of the collagen-binding domain from a Staphylococcus aureus adhesin."
] | [
1997
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Caudoviricetes",
"metagenomes"
] | [
3111,
13,
2
] | 3 | [] | [] | 0 | true | Domain | Collagen binding domain | Collagen binding domain | Collagen-bd_dom | 3 |
IPR008457 | 8,457 | Copper resistance protein D domain | Cu-R_CopD_dom | Domain | 17,148 | false | false | Copper sequestering activity displayed by some bacteria is determined by copper-binding protein products of the copper resistance operon (cop). CopD, together with CopC, perform copper uptake into the cytoplasm [ ]. | [
"GO:0016020"
] | [
"membrane"
] | [
"cellular_component"
] | 1 | [
"PFAM"
] | [
"PF05425"
] | [
"CopD"
] | [
17148
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00011301"
] | [
"7917425"
] | [
"Molecular mechanisms of copper resistance and accumulation in bacteria."
] | [
1994
] | 1 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
330,
16449,
12,
357
] | 4 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Domain | Copper resistance protein D domain | Copper resistance protein D domain | Cu-R_CopD_dom | 7 |
IPR008458 | 8,458 | Accessory protein 5b, avian coronavirus | Acc_prot_5b_avian_CoV | Family | 317 | false | false | Avian infectious bronchitis virus, a member of Coronaviridae family, has a single-stranded positive-sense RNA genome, which is 27 kb in length. Gene 5 contains two (5a and 5b) open reading frames [ ]. This entry represents the host translation inhibitor 5b (ORF 5b, also known as accessory protein 5b) which is involved ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF05528"
] | [
"Acc5b_avian_CoV"
] | [
317
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00008387",
"PUB00099597"
] | [
"9168126",
"27279618"
] | [
"Sequence analysis of gene 3, gene 4 and gene 5 of avian infectious bronchitis virus strain CU-T2.",
"Infectious Bronchitis Coronavirus Limits Interferon Production by Inducing a Host Shutoff That Requires Accessory Protein 5b."
] | [
1997,
2016
] | 2 | [] | [] | 0 | 0 | null | [
"Diversispora epigaea",
"Gammacoronavirus"
] | [
1,
316
] | 2 | [] | [] | 0 | true | Family | Accessory protein 5b, avian coronavirus | Accessory protein 5b, avian coronavirus | Acc_prot_5b_avian_CoV | 1 |
IPR008461 | 8,461 | Lycopene cyclase, pseudomonadota | CrtY_pseudo | Family | 996 | false | false | This family consists of several bacterial Lycopene cyclase (CrtY) proteins (also known as Lycopene beta-cyclase) mainly found in Pseudomonadota. Lycopene cyclase is a key enzyme which converts the acyclic carotenoid lycopene into the cyclic carotenoid beta-carotene [ ]. It is thought that CrtY lycopene cyclases use red... | [
"GO:0045436",
"GO:0016117"
] | [
"lycopene beta cyclase activity",
"carotenoid biosynthetic process"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"NCBIFAM"
] | [
"TIGR01789"
] | [
"lycopene_cycl"
] | [
996
] | 1 | [
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC"
] | [
"5.5.1.19",
"PWY-5943",
"PWY-5946",
"PWY-5947",
"PWY-6279",
"PWY-7591",
"PWY-7938",
"PWY-7939",
"PWY-7947"
] | [
"EC:5.5.1.19",
"METACYC:PWY-5943",
"METACYC:PWY-5946",
"METACYC:PWY-5947",
"METACYC:PWY-6279",
"METACYC:PWY-7591",
"METACYC:PWY-7938",
"METACYC:PWY-7939",
"METACYC:PWY-7947"
] | 9 | [] | 0 | [
"PUB00011302",
"PUB00011586",
"PUB00053852",
"PUB00106873",
"PUB00106874"
] | [
"9168123",
"8837512",
"20178989",
"12782726",
"25943989"
] | [
"Cloning, sequencing and expressing the carotenoid biosynthesis genes, lycopene cyclase and phytoene desaturase, from the aerobic photosynthetic bacterium Erythrobacter longus sp. strain Och101 in Escherichia coli.",
"Functional analysis of the beta and epsilon lycopene cyclase enzymes of Arabidopsis reveals a me... | [
1997,
1996,
2010,
2003,
2015
] | 5 | [
"IPR010108"
] | [] | 1 | 0 | 1 | [
"Bacteria",
"Ecdysozoa",
"ecological metagenomes"
] | [
991,
2,
3
] | 3 | [] | [] | 0 | true | Family | Lycopene cyclase, pseudomonadota | Lycopene cyclase, pseudomonadota | CrtY_pseudo | 2 |
IPR008462 | 8,462 | CsbD-like domain | CsbD | Domain | 20,698 | false | false | CsbD is a bacterial general stress response protein. Its expression is mediated by sigma-B, an alternative sigma factor [ ]. The exact role of CsbD in stress response is unclear. This entry represents CsbD, and related proteins. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF05532"
] | [
"CsbD"
] | [
20698
] | 1 | [] | [] | [] | 0 | [
"1ryk",
"1yww"
] | 2 | [
"PUB00011303"
] | [
"11988534"
] | [
"Regulatory interactions between the Pho and sigma(B)-dependent general stress regulons of Bacillus subtilis."
] | [
2002
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Caudoviricetes",
"Eukaryota",
"Methanomicrobia",
"metagenomes"
] | [
19839,
3,
774,
14,
68
] | 5 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Domain | CsbD-like domain | CsbD-like domain | CsbD | 8 |
IPR008463 | 8,463 | Transcriptional regulator CtsR | CtsR | Family | 3,207 | false | false | This family consists of several transcriptional repressor of class III stress gene (CtsR) proteins, mainly from Firmicute species. CtsR of Listeria monocytogenes negatively regulates the clpC, clpP and clpE genes belonging to the CtsR regulon [ ]. | [
"GO:0003677",
"GO:0006355"
] | [
"DNA binding",
"regulation of DNA-templated transcription"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PIRSF"
] | [
"PIRSF010607"
] | [
"Txn_repr_CtsR"
] | [
3207
] | 1 | [] | [] | [] | 0 | [
"3h0d"
] | 1 | [
"PUB00011304"
] | [
"10692157"
] | [
"CtsR controls class III heat shock gene expression in the human pathogen Listeria monocytogenes."
] | [
2000
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"unclassified sequences"
] | [
3199,
8
] | 2 | [] | [] | 0 | true | Family | Transcriptional regulator CtsR | Transcriptional regulator CtsR | CtsR | 8 |
IPR008464 | 8,464 | Cypovirus polyhedrin, Cypovirus 1 type | Cypo_polyhedrin_Cypovirus1 | Family | 16 | false | false | This family consists of several Cypovirus polyhedrin proteins mostly from Cypovirus 1. Polyhedrin is known to form a crystalline matrix (polyhedra) in infected insect cells [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF05865"
] | [
"Cypo_polyhedrin"
] | [
16
] | 1 | [] | [] | [] | 0 | [
"2oh5",
"2oh6",
"2oh7",
"4ots",
"4otv",
"4x35",
"5a9b",
"5a9p",
"5axu",
"5axv",
"5exy",
"5exz",
"5gqi",
"5gqj",
"5gqk",
"5gql",
"5gqm",
"5gqn",
"5mqw",
"5yha",
"5yhb",
"5yr1",
"5yr9",
"5yra",
"5yrb",
"5yrc",
"5yrd",
"6lee",
"7wyr",
"7xhr",
"7xws",
"8j2q"... | 35 | [
"PUB00011305"
] | [
"8286955"
] | [
"Expression in Escherichia coli of the cloned polyhedrin gene of Bombyx mori cytoplasmic polyhedrosis virus."
] | [
1993
] | 1 | [] | [] | 0 | 0 | null | [
"Cypovirus"
] | [
16
] | 1 | [] | [] | 0 | true | Family | Cypovirus polyhedrin, Cypovirus 1 type | Cypovirus polyhedrin, Cypovirus 1 type | Cypo_polyhedrin_Cypovirus1 | 5 |
IPR008465 | 8,465 | Dystroglycan, C-terminal | DAG1_C | Domain | 2,046 | false | false | Dystroglycan is one of the dystrophin-associated glycoproteins, which is encoded by a 5.5 kb transcript in Homo sapiens. The protein product is cleaved into two non-covalently associated subunits, [alpha] (N-terminal) and [beta] (C-terminal). In skeletal muscle the dystroglycan complex works as a transmembrane linkage ... | [
"GO:0016010"
] | [
"dystrophin-associated glycoprotein complex"
] | [
"cellular_component"
] | 1 | [
"PFAM"
] | [
"PF05454"
] | [
"DAG1"
] | [
2046
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-CFA-8932504",
"R-CFA-8932505",
"R-CFA-8932506",
"R-CFA-9010553",
"R-CFA-9913351",
"R-CFA-9939291",
"R-HSA-3000171",
"R-HSA-3000178",
"R-HSA-5083628",
"R-HSA-5083629",
"R-HSA-5083633",
"R-HSA-8932504",
"R-HSA-8932505",
"R-HSA-8932506",
"R-HSA-9010553",
"R-HSA-9619665",
"R-HSA-99133... | [
"REACTOME:R-CFA-8932504",
"REACTOME:R-CFA-8932505",
"REACTOME:R-CFA-8932506",
"REACTOME:R-CFA-9010553",
"REACTOME:R-CFA-9913351",
"REACTOME:R-CFA-9939291",
"REACTOME:R-HSA-3000171",
"REACTOME:R-HSA-3000178",
"REACTOME:R-HSA-5083628",
"REACTOME:R-HSA-5083629",
"REACTOME:R-HSA-5083633",
"REACTOM... | 24 | [
"8uf4",
"8yt8",
"9c3c"
] | 3 | [
"PUB00011306",
"PUB00061702"
] | [
"8872465",
"1913804"
] | [
"Cloning and expression analyses of mouse dystroglycan gene: specific expression in maternal decidua at the peri-implantation stage.",
"Membrane organization of the dystrophin-glycoprotein complex."
] | [
1996,
1991
] | 2 | [] | [] | 0 | 0 | null | [
"Opisthokonta"
] | [
2046
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
3,
7,
1,
5,
3
] | 6 | true | Domain | Dystroglycan, C-terminal | Dystroglycan, C-terminal | DAG1_C | 2 |
IPR008466 | 8,466 | Protein phosphatase inhibitor 1 | PPP1R1A/B/C | Family | 2,661 | false | false | This entry represents the protein phosphatase inhibitor 1 (IPP-1) family, which consists of PPP1R1A/B/C. They are involved in signal transduction and are endogenous inhibitors of protein phosphatase-1 [ ]. PPP1R1B, also known as DARPP-32, has a key role in many neurotransmitter pathways throughout the brain and has bee... | [
"GO:0004864",
"GO:0007165"
] | [
"protein phosphatase inhibitor activity",
"signal transduction"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PFAM",
"PANTHER"
] | [
"PF05395",
"PTHR15417"
] | [
"DARPP-32",
""
] | [
2650,
2614
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-180024",
"R-HSA-180024",
"R-MMU-180024",
"R-RNO-180024"
] | [
"REACTOME:R-BTA-180024",
"REACTOME:R-HSA-180024",
"REACTOME:R-MMU-180024",
"REACTOME:R-RNO-180024"
] | 4 | [] | 0 | [
"PUB00011307",
"PUB00011308",
"PUB00011310"
] | [
"10960791",
"12543476",
"12124342"
] | [
"Expression and genomic characterization of protein phosphatase inhibitor-1: a novel marker for mesothelium in the mouse.",
"Dopamine and cyclic AMP-regulated phosphoprotein immunoreactive neurons are innervated by axon terminals immunopositive for vasoactive intestinal polypeptide in the bed nuclei of the stria ... | [
2000,
2003,
2002
] | 3 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"bird metagenome"
] | [
2660,
1
] | 2 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
9,
12,
4,
17
] | 4 | true | Family | Protein phosphatase inhibitor 1 | Protein phosphatase inhibitor 1 | PPP1R1A/B/C | 2 |
IPR008467 | 8,467 | Dynein 1 light intermediate chain | Dynein1_light_intermed_chain | Family | 5,888 | false | false | Cytoplasmic dynein is a large multisubunit complex involved in retrograde transport and the positioning of various organelles. The light intermediate chains (LICs) of cytoplasmic dynein consist of multiple isoforms, which undergo post-translational modification to produce a large number of species. Proteins in this ent... | [
"GO:0007018",
"GO:0005868"
] | [
"microtubule-based movement",
"cytoplasmic dynein complex"
] | [
"biological_process",
"cellular_component"
] | 2 | [
"PANTHER"
] | [
"PTHR12688"
] | [
""
] | [
5888
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-DDI-6798695",
"R-DDI-6807878",
"R-DDI-9646399",
"R-GGA-141444",
"R-GGA-2467813",
"R-GGA-2500257",
"R-GGA-3371497",
"R-GGA-5663220",
"R-GGA-6798695",
"R-GGA-6807878",
"R-GGA-6811436",
"R-GGA-9646399",
"R-GGA-9648025",
"R-HSA-141444",
"R-HSA-2132295",
"R-HSA-2467813",
"R-HSA-2500257... | [
"REACTOME:R-DDI-6798695",
"REACTOME:R-DDI-6807878",
"REACTOME:R-DDI-9646399",
"REACTOME:R-GGA-141444",
"REACTOME:R-GGA-2467813",
"REACTOME:R-GGA-2500257",
"REACTOME:R-GGA-3371497",
"REACTOME:R-GGA-5663220",
"REACTOME:R-GGA-6798695",
"REACTOME:R-GGA-6807878",
"REACTOME:R-GGA-6811436",
"REACTOME... | 51 | [
"4w7g",
"6f1t",
"6f1y",
"6f38",
"6f3a",
"7z8f",
"7z8i",
"7z8j",
"7z8k",
"7z8l",
"8pr0",
"8pr1",
"8pr2",
"8pr3",
"8ptk",
"9bly",
"9dgq",
"9dgr",
"9dgt",
"9dgu",
"9e12",
"9e13",
"9e14",
"9e23",
"9e28"
] | 25 | [
"PUB00094515"
] | [
"19229290"
] | [
"Dynein light intermediate chain 1 is required for progress through the spindle assembly checkpoint."
] | [
2009
] | 1 | [
"IPR022780"
] | [] | 1 | 0 | 1 | [
"Eukaryota"
] | [
5888
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
2,
15,
2,
14,
8,
1,
16,
1
] | 8 | true | Family | Dynein 1 light intermediate chain | Dynein 1 light intermediate chain | Dynein1_light_intermed_chain | 1 |
IPR008468 | 8,468 | DNA methyltransferase 1-associated 1 | DMAP1 | Domain | 2,713 | false | false | This entry represents a domain found in DNA methyltransferase 1-associated protein 1 (DMAP1). | [
"GO:0045892",
"GO:0005634"
] | [
"negative regulation of DNA-templated transcription",
"nucleus"
] | [
"biological_process",
"cellular_component"
] | 2 | [
"PFAM"
] | [
"PF05499"
] | [
"DMAP1"
] | [
2713
] | 1 | [
"REACTOME"
] | [
"R-HSA-3214847"
] | [
"REACTOME:R-HSA-3214847"
] | 1 | [
"8qr1",
"8x15",
"8x19",
"8x1c",
"8xvg",
"8xvt",
"9c57",
"9c62",
"9c6n",
"9cac",
"9cae"
] | 11 | [
"PUB00011312"
] | [
"10888872"
] | [
"DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex at replication foci."
] | [
2000
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"uncultured bacterium contig00055"
] | [
2712,
1
] | 2 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
2,
2,
1,
1,
3,
1,
4,
5,
11
] | 9 | true | Domain | DNA methyltransferase 1-associated 1 | DNA methyltransferase 1-associated 1 | DMAP1 | 2 |
IPR008469 | 8,469 | DREPP family | DREPP | Family | 767 | false | false | This family contains several plant plasma membrane proteins termed DREPPs as they are developmentally regulated plasma membrane polypeptides [ ], including the salt stress root protein RS1 and plasma membrane-associated cation-binding protein 1 (PCAP1). DREPPs are thought to be signal proteins [ ]. | [
"GO:0005886"
] | [
"plasma membrane"
] | [
"cellular_component"
] | 1 | [
"PFAM",
"PANTHER"
] | [
"PF05558",
"PTHR38522"
] | [
"DREPP",
""
] | [
766,
713
] | 2 | [] | [] | [] | 0 | [] | 0 | [
"PUB00011313",
"PUB00066820",
"PUB00089925"
] | [
"9415814",
"17264065",
"28108158"
] | [
"A new family of plasma membrane polypeptides differentially regulated during plant development.",
"Molecular properties of a novel, hydrophilic cation-binding protein associated with the plasma membrane.",
"Evolutionary plasticity of plasma membrane interaction in DREPP family proteins."
] | [
1997,
2007,
2017
] | 3 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
767
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
8,
4,
19
] | 3 | true | Family | DREPP family | DREPP family | DREPP | 1 |
IPR008470 | 8,470 | Uncharacterised protein family Ycf33 | Uncharacterised_Ycf33 | Family | 1,265 | false | false | This family, Ycf33, contains several plant, cyanobacterial and algal chlorplast encoded proteins of unknown function. The family is exclusively found in phototrophic organisms and may therefore play a role in photosynthesis. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF05421"
] | [
"DUF751"
] | [
1265
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Cyanobacteriota",
"Eukaryota"
] | [
353,
912
] | 2 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
6,
2,
5
] | 3 | true | Family | Uncharacterised protein family Ycf33 | Uncharacterised protein family Ycf33 | Uncharacterised_Ycf33 | 4 |
IPR008472 | 8,472 | Domain of unknown function DUF753 | DUF753 | Domain | 704 | false | false | This entry contains sequences which are repeated in several uncharacterised proteins from Drosophila melanogaster. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF05444"
] | [
"DUF753"
] | [
704
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Protostomia"
] | [
704
] | 1 | [
"Drosophila melanogaster"
] | [
14
] | 1 | true | Domain | Domain of unknown function DUF753 | Domain of unknown function DUF753 | DUF753 | 7 |
IPR008473 | 8,473 | Putative 3TM holin, Phage holin 3 | Phage_holin_3_7 | Family | 1,566 | false | false | This is a family of putative proteobacterial phage three-transmembrane-domain holins. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF05449"
] | [
"Phage_holin_3_7"
] | [
1566
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Caudoviricetes",
"Eukaryota",
"Pseudomonadota",
"metagenomes"
] | [
58,
2,
1502,
4
] | 4 | [] | [] | 0 | true | Family | Putative 3TM holin, Phage holin 3 | Putative 3TM holin, Phage holin 3 | Phage_holin_3_7 | 5 |
IPR008474 | 8,474 | Protein of unknown function DUF755 | DUF755 | Domain | 86 | false | false | This family is predominated by ORFs from Anelloviridae. The function of this family remains to be determined. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF05501"
] | [
"DUF755"
] | [
86
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Anelloviridae"
] | [
86
] | 1 | [] | [] | 0 | true | Domain | Protein of unknown function DUF755 | Protein of unknown function DUF755 | DUF755 | 1 |
IPR008476 | 8,476 | Protein PBDC1, metazoa/fungi | PBDC1_metazoa/fungi | Family | 3,336 | false | false | This entry represents the family of protein PBDC1 (polysaccharide biosynthesis domain-containing protein 1). Proteins in this entry are from fungi and animals. The budding yeast PBDC1 homologue is known as YPL225W. Protein PBDC1 homolog from S. cerevisiae also known as Ypl225w (Chp1, Chaperone 1 for eEF1A) functions as... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR13410"
] | [
""
] | [
3336
] | 1 | [] | [] | [] | 0 | [
"2jyn"
] | 1 | [
"PUB00160075",
"PUB00160942"
] | [
"39900909",
"38360885"
] | [
"A ribosome-associating chaperone mediates GTP-driven vectorial folding of nascent eEF1A.",
"Chp1 is a dedicated chaperone at the ribosome that safeguards eEF1A biogenesis."
] | [
2025,
2024
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Mucilaginibacter ginsenosidivorax"
] | [
3335,
1
] | 2 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strai... | [
2,
1,
2,
4,
1,
1,
4,
1,
1
] | 9 | true | Family | Protein PBDC1, metazoa/fungi | Protein PBDC1, metazoa/fungi | PBDC1_metazoa/fungi | 6 |
IPR008477 | 8,477 | Tumor necrosis factor alpha-induced protein 8-like | TNFAIP8-like | Family | 4,087 | false | false | Four tumor necrosis factor alpha-induced protein 8-like proteins have been identified: TNFAIP8 (also known as TIPE), TIPE1, TIPE2 and TIPE3. Overexpressed TIPE in cells can reduce cell death in vitro and increase tumor growth in vivo [ ]. By contrast, TIPE2 has been demonstrated to be an inhibitor of Ras and to have a ... | [
"GO:0042981"
] | [
"regulation of apoptotic process"
] | [
"biological_process"
] | 1 | [
"PFAM",
"PANTHER"
] | [
"PF05527",
"PTHR12757"
] | [
"TNFAIP8",
""
] | [
4087,
3973
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-1483255",
"R-DME-1483255",
"R-DRE-1483255",
"R-GGA-1483255",
"R-HSA-1483255",
"R-MMU-1483255",
"R-RNO-1483255",
"R-XTR-1483255"
] | [
"REACTOME:R-BTA-1483255",
"REACTOME:R-DME-1483255",
"REACTOME:R-DRE-1483255",
"REACTOME:R-GGA-1483255",
"REACTOME:R-HSA-1483255",
"REACTOME:R-MMU-1483255",
"REACTOME:R-RNO-1483255",
"REACTOME:R-XTR-1483255"
] | 8 | [
"3f4m",
"4q9v",
"5jxd",
"5z1n",
"5z39",
"8gyn"
] | 6 | [
"PUB00086471",
"PUB00086472"
] | [
"27900028",
"10644768"
] | [
"Tumor necrosis factor α-induced protein 8-like 1 promotes apoptosis by regulating B-cell leukemia/lymphoma-2 family proteins in RAW264.7 cells.",
"Identification of a novel tumor necrosis factor-alpha-inducible gene, SCC-S2, containing the consensus sequence of a death effector domain of fas-associated death dom... | [
2016,
2000
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
4087
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
5,
4,
9,
11,
15
] | 5 | true | Family | Tumor necrosis factor alpha-induced protein 8-like | Tumor necrosis factor alpha-induced protein 8-like | TNFAIP8-like | 5 |
IPR008478 | 8,478 | Protein of unknown function DUF759, Borrelia species | DUF759_BOR_spp | Family | 161 | false | false | This entry consists of several uncharacterised proteins from Borrelia species including Borrelia burgdorferi and Borrelia garinii. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF05537"
] | [
"DUF759"
] | [
161
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Borreliaceae"
] | [
161
] | 1 | [] | [] | 0 | true | Family | Protein of unknown function DUF759, Borrelia species | Protein of unknown function DUF759, Borrelia species | DUF759_BOR_spp | 7 |
IPR008479 | 8,479 | Protein of unknown function DUF760 | DUF760 | Family | 5,166 | false | false | This entry represents a family of uncharacterised proteins, including chloroplastic UV-B-induced protein At3g17800 from Arabidopsis. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF05542"
] | [
"DUF760"
] | [
5166
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [
"IPR038925"
] | 0 | 1 | 0 | [
"Bacteria",
"Eukaryota",
"marine metagenome"
] | [
723,
4442,
1
] | 3 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
40,
26,
36
] | 3 | true | Family | Protein of unknown function DUF760 | Protein of unknown function DUF760 | DUF760 | 2 |
IPR008480 | 8,480 | Protein of unknown function DUF761, plant | DUF761_pln | Family | 14,341 | false | false | This family consists of several plant proteins of unknown function, including pathogen-associated molecular patterns-induced protein A70 from Arabidopsis thaliana, which is induced during Pseudomonas syringae infection by jasmonic acid and wounding [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF05553"
] | [
"DUF761"
] | [
14341
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00090980"
] | [
"17215350"
] | [
"Arabidopsis systemic immunity uses conserved defense signaling pathways and is mediated by jasmonates."
] | [
2007
] | 1 | [] | [] | 0 | 0 | null | [
"Embryophyta"
] | [
14341
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
120,
71,
106
] | 3 | true | Family | Protein of unknown function DUF761, plant | Protein of unknown function DUF761, plant | DUF761_pln | 3 |
IPR008481 | 8,481 | Protein of unknown function DUF762, Coxiella burnetii | DUF762_COXBU | Family | 18 | false | false | This family consists several of several uncharacterised proteins from the bacterium Coxiella burnetii. C. burnetii is the causative agent of the Q fever disease. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF05555"
] | [
"DUF762"
] | [
18
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Corchorus capsularis",
"Coxiella burnetii"
] | [
1,
17
] | 2 | [] | [] | 0 | true | Family | Protein of unknown function DUF762, Coxiella burnetii | Protein of unknown function DUF762, Coxiella burnetii | DUF762_COXBU | 1 |
IPR008483 | 8,483 | Protein of unknown function DUF764, Borrelia species | DUF764_BOR_spp | Family | 158 | false | false | This entry consists of several uncharacterised proteins from Borrelia species including Borrelia burgdorferi and Borrelia garinii. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF05561"
] | [
"DUF764"
] | [
158
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Borreliaceae"
] | [
158
] | 1 | [] | [] | 0 | true | Family | Protein of unknown function DUF764, Borrelia species | Protein of unknown function DUF764, Borrelia species | DUF764_BOR_spp | 2 |
IPR008484 | 8,484 | Circovirus Orf6 | Circovirus_Orf6 | Family | 11 | false | false | This family consists of several short (27-30aa) porcine and bovine circovirus ORF6 proteins of unknown function. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF05570"
] | [
"DUF765"
] | [
11
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Porcine circovirus 2"
] | [
11
] | 1 | [] | [] | 0 | true | Family | Circovirus Orf6 | Circovirus Orf6 | Circovirus_Orf6 | 4 |
IPR008485 | 8,485 | JNK1/MAPK8-associated membrane protein | JAMP | Family | 1,908 | false | false | JAMP is a Jun N-terminal kinase 1 (JNK1)-associated membrane protein. It associates with JNK1 through its C-terminal domain and regulates the duration of JNK1 activity in response to diverse stress stimuli [ ]. It is an important component for coordinated clearance of misfolded proteins from the ER [ , ]. | [
"GO:0006986",
"GO:0016020"
] | [
"response to unfolded protein",
"membrane"
] | [
"biological_process",
"cellular_component"
] | 2 | [
"PFAM",
"PANTHER"
] | [
"PF05571",
"PTHR12740"
] | [
"JAMP",
""
] | [
1908,
1835
] | 2 | [] | [] | [] | 0 | [] | 0 | [
"PUB00086473",
"PUB00086474",
"PUB00086475"
] | [
"16166642",
"18784250",
"19269966"
] | [
"JAMP, a Jun N-terminal kinase 1 (JNK1)-associated membrane protein, regulates duration of JNK activity.",
"JAMP optimizes ERAD to protect cells from unfolded proteins.",
"Regulation of endoplasmic reticulum-associated degradation by RNF5-dependent ubiquitination of JNK-associated membrane protein (JAMP)."
] | [
2005,
2008,
2009
] | 3 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1908
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
2,
3,
6,
3,
5
] | 6 | true | Family | JNK1/MAPK8-associated membrane protein | JNK1/MAPK8-associated membrane protein | JAMP | 9 |
IPR008486 | 8,486 | Protein of unknown function DUF768 | DUF768 | Family | 44 | false | false | This family consists of several uncharacterised hypothetical proteins mostly from proteobacteria. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF05589"
] | [
"DUF768"
] | [
44
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Pseudomonadota",
"freshwater metagenome"
] | [
43,
1
] | 2 | [] | [] | 0 | true | Family | Protein of unknown function DUF768 | Protein of unknown function DUF768 | DUF768 | 1 |
IPR008487 | 8,487 | Protein of unknown function DUF769 | DUF769 | Family | 63 | false | false | This family consists of several uncharacterised hypothetical proteins of unknown function from Xylella fastidiosa, the organism that causes Pierce's disease in plants. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF05590"
] | [
"DUF769"
] | [
63
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Pichia membranifaciens",
"Pseudomonadota"
] | [
1,
62
] | 2 | [] | [] | 0 | true | Family | Protein of unknown function DUF769 | Protein of unknown function DUF769 | DUF769 | 3 |
IPR008489 | 8,489 | Protein of unknown function DUF771 | DUF771 | Family | 876 | false | false | This entry includes Bacteriophage bIL285, Orf7. The characteristics of the protein distribution suggest prophage matches in addition to the phage matches. This entry consists of uncharacterised ORFs found in Bacteriophage and Lactococcus lactis. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF05595"
] | [
"DUF771"
] | [
876
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Caudoviricetes",
"Halobaculum halobium",
"metagenomes"
] | [
825,
46,
1,
4
] | 4 | [] | [] | 0 | true | Family | Protein of unknown function DUF771 | Protein of unknown function DUF771 | DUF771 | 7 |
IPR008490 | 8,490 | Transposase InsH, N-terminal | Transposase_InsH_N | Domain | 28,188 | false | false | This presumed domain is found at the N terminus of Transposase InsH for insertion sequence element IS5A from Escherichia coli (strain K12) and other related transposases found in bacteria and archaea. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF05598"
] | [
"DUF772"
] | [
28188
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"plasmids",
"unclassified sequences"
] | [
440,
27062,
69,
9,
2,
606
] | 6 | [
"Escherichia coli (strain K12)"
] | [
19
] | 1 | true | Domain | Transposase InsH, N-terminal | Transposase InsH, N-terminal | Transposase_InsH_N | 3 |
IPR008491 | 8,491 | CDK5 regulatory subunit-associated protein 3 | CDK5RAP3 | Family | 3,853 | false | false | CDK5RAP3 (also known as C53 or LZAP) serves as a probable tumour suppressor initially identified as a CDK5R1 interactor controlling cell proliferation [ , ]. It negatively regulates NF-kappa-B-mediated gene transcription through the control of RELA phosphorylation [ , ]. It also regulates mitotic G2/M transition checkp... | [] | [] | [] | 0 | [
"PFAM",
"PANTHER"
] | [
"PF05600",
"PTHR14894"
] | [
"CDK5RAP3",
""
] | [
3843,
3685
] | 2 | [] | [] | [] | 0 | [
"8ohd",
"8oj0",
"8oj5",
"8qfc",
"9gy4"
] | 5 | [
"PUB00043152",
"PUB00086010",
"PUB00086011",
"PUB00086012",
"PUB00086013",
"PUB00086014",
"PUB00086015"
] | [
"17785205",
"12054757",
"20228063",
"15790566",
"19223857",
"12737517",
"28027003"
] | [
"LZAP, a putative tumor suppressor, selectively inhibits NF-kappaB.",
"A novel gene IC53 stimulates ECV304 cell proliferation and is upregulated in failing heart.",
"A novel C53/LZAP-interacting protein regulates stability of C53/LZAP and DDRGK domain-containing Protein 1 (DDRGK1) and modulates NF-kappaB signal... | [
2007,
2002,
2010,
2005,
2009,
2003,
2017
] | 7 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"bird metagenome"
] | [
2,
3850,
1
] | 3 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
3,
1,
1,
1,
12,
10,
2,
7,
9
] | 9 | true | Family | CDK5 regulatory subunit-associated protein 3 | CDK5 regulatory subunit-associated protein 3 | CDK5RAP3 | 4 |
IPR008492 | 8,492 | Rv2714-like | Rv2714-like | Family | 7,887 | false | false | This family, previously known as DUF774, consists of uncharacterised proteins predominantly found in Actinomycetes, including Rv2714 ( ) from Mycobacterium tuberculosis. This protein adopts a trimeric configuration, in which each monomer is organised into two domains: a central β-sheet of eight strands flanked by three... | [] | [] | [] | 0 | [
"PIRSF"
] | [
"PIRSF028754"
] | [
"UCP028754"
] | [
7887
] | 1 | [] | [] | [] | 0 | [
"2p90",
"2wam",
"3e35",
"3mnf",
"5un0"
] | 5 | [
"PUB00100672",
"PUB00100673"
] | [
"19851001",
"28193903"
] | [
"Structure of Mycobacterium tuberculosis Rv2714, a representative of a duplicated gene family in Actinobacteria.",
"Structural Analysis of Mycobacterium tuberculosis Homologues of the Eukaryotic Proteasome Assembly Chaperone 2 (PAC2)."
] | [
2009,
2017
] | 2 | [
"IPR019151"
] | [] | 1 | 0 | 1 | [
"Bacteria",
"Geodia barretti",
"metagenomes"
] | [
7597,
1,
289
] | 3 | [] | [] | 0 | true | Family | Rv2714-like | Rv2714-like | Rv2714-like | 9 |
IPR008493 | 8,493 | Hikeshi-like, N-terminal domain | Hikeshi-like_N | Domain | 3,942 | false | false | This entry represents a domain found at the N-terminal of human Hikeshi and its orthologues OPI10 from other eukaryotes. Hikeshi acts as a specific nuclear import carrier for HSP70 proteins following heat-shock stress; it acts by mediating the nucleoporin-dependent translocation of ATP-bound HSP70 proteins into the nuc... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF05603"
] | [
"Hikeshi-like_N"
] | [
3942
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-3371453",
"R-DDI-3371453",
"R-DRE-3371453",
"R-HSA-3371453",
"R-MMU-3371453",
"R-RNO-3371453",
"R-SCE-3371453",
"R-SPO-3371453",
"R-XTR-3371453"
] | [
"REACTOME:R-BTA-3371453",
"REACTOME:R-DDI-3371453",
"REACTOME:R-DRE-3371453",
"REACTOME:R-HSA-3371453",
"REACTOME:R-MMU-3371453",
"REACTOME:R-RNO-3371453",
"REACTOME:R-SCE-3371453",
"REACTOME:R-SPO-3371453",
"REACTOME:R-XTR-3371453"
] | 9 | [
"3wvz",
"3ww0"
] | 2 | [
"PUB00075511",
"PUB00101202",
"PUB00101203"
] | [
"22541429",
"24768994",
"25760597"
] | [
"Hikeshi, a nuclear import carrier for Hsp70s, protects cells from heat shock-induced nuclear damage.",
"The Schizosaccharomyces pombe Hikeshi/Opi10 protein has similar biochemical functions to its human homolog but acts in different physiological contexts.",
"Structural and functional analysis of Hikeshi, a ne... | [
2012,
2014,
2015
] | 3 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
3942
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
4,
4,
1,
2,
3,
3,
1,
2,
4,
1,
1,
2
] | 12 | true | Domain | Hikeshi-like, N-terminal domain | Hikeshi-like, N-terminal domain | Hikeshi-like_N | 3 |
IPR008494 | 8,494 | Protein of unknown function DUF776 | DUF776 | Family | 1,729 | false | false | This family consists of several highly related Mus musculus and Homo sapiens proteins of unknown function. | [] | [] | [] | 0 | [
"PFAM",
"PANTHER"
] | [
"PF05604",
"PTHR31383"
] | [
"DUF776",
""
] | [
1303,
1726
] | 2 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Metazoa"
] | [
1729
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
1,
3,
1,
3,
3
] | 6 | true | Family | Protein of unknown function DUF776 | Protein of unknown function DUF776 | DUF776 | 5 |
IPR008495 | 8,495 | Protein of unknown function DUF777, Borrelia species | DUF777_BOR_spp | Family | 169 | false | false | This family consists of several hypothetical proteins of unknown function, found in Borrelia burgdorferi and Borrelia garinii. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF05606"
] | [
"DUF777"
] | [
169
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Borreliaceae"
] | [
169
] | 1 | [] | [] | 0 | true | Family | Protein of unknown function DUF777, Borrelia species | Protein of unknown function DUF777, Borrelia species | DUF777_BOR_spp | 8 |
IPR008496 | 8,496 | TMEM222/RTE1 | TMEM222/RTE1 | Family | 3,767 | false | false | This entry includes TMEM222 from animals and RTE1 (REVERSION-TO-ETHYLENE SENSITIVITY1) from Arabidopsis. RTE1 is positive regulator of the ETR1 ethylene receptor [ , ]. This entry also includes Arabidopsis RTE1 homologue, RTH, which acts via RTE1 in regulating ethylene responses and signaling [ ]. | [] | [] | [] | 0 | [
"PFAM",
"PANTHER"
] | [
"PF05608",
"PTHR20921"
] | [
"RTE1",
""
] | [
3764,
3669
] | 2 | [] | [] | [] | 0 | [] | 0 | [
"PUB00092499",
"PUB00092500",
"PUB00092501"
] | [
"18643990",
"16682642",
"28541511"
] | [
"Involvement of RTE1 in conformational changes promoting ETR1 ethylene receptor signaling in Arabidopsis.",
"REVERSION-TO-ETHYLENE SENSITIVITY1, a conserved gene that regulates ethylene receptor function in Arabidopsis.",
"Molecular association of Arabidopsis RTH with its homolog RTE1 in regulating ethylene sig... | [
2008,
2006,
2017
] | 3 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
3767
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
10,
1,
4,
2,
9,
3,
8,
4,
14
] | 9 | true | Family | TMEM222/RTE1 | TMEM222/RTE1 | TMEM222/RTE1 | 5 |
IPR008497 | 8,497 | Protein of unknown function DUF779 | DUF779 | Family | 6,386 | false | false | This family consists of several bacterial proteins of unknown function. | [] | [] | [] | 0 | [
"PFAM",
"PIRSF"
] | [
"PF05610",
"PIRSF009151"
] | [
"DUF779",
"DUF779"
] | [
6386,
5483
] | 2 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
6,
6316,
2,
62
] | 4 | [] | [] | 0 | true | Family | Protein of unknown function DUF779 | Protein of unknown function DUF779 | DUF779 | 1 |
IPR008498 | 8,498 | Protein of unknown function DUF780, Caenorhabditis species | DUF780_CAE_spp | Family | 147 | false | false | This family consists of several short proteins of unknown function found in Caenorhabditis species. | [] | [] | [] | 0 | [
"PFAM",
"PANTHER"
] | [
"PF05611",
"PTHR35375"
] | [
"DUF780",
""
] | [
146,
114
] | 2 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Rhabditida"
] | [
147
] | 1 | [
"Caenorhabditis elegans"
] | [
8
] | 1 | true | Family | Protein of unknown function DUF780, Caenorhabditis species | Protein of unknown function DUF780, Caenorhabditis species | DUF780_CAE_spp | 1 |
IPR008500 | 8,500 | Circovirus Orf3 | Circovirus_Orf3 | Family | 147 | false | false | This family consists of porcine circovirus ORF3 protein which plays a role in modulating host cell signalling by binding to and degrading host RGS16 [ ]. This protein is not necessary for virus replication [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF05614"
] | [
"Circovir_ORF3"
] | [
147
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00097771",
"PUB00097772"
] | [
"15956572",
"25575706"
] | [
"Characterization of a previously unidentified viral protein in porcine circovirus type 2-infected cells and its role in virus-induced apoptosis.",
"The ORF3 protein of porcine circovirus type 2 promotes secretion of IL-6 and IL-8 in porcine epithelial cells by facilitating proteasomal degradation of regulator of... | [
2005,
2015
] | 2 | [] | [] | 0 | 0 | null | [
"Circovirus"
] | [
147
] | 1 | [] | [] | 0 | true | Family | Circovirus Orf3 | Circovirus Orf3 | Circovirus_Orf3 | 6 |
IPR008501 | 8,501 | THO complex subunit 7/Mft1 | THOC7/Mft1 | Family | 4,938 | false | false | The THO complex (THOC) is involved in transcription elongation and mRNA export from the nucleus [ ]. This entry represents the subunit THOC7, which is found in higher eukaryotes, and the non-homologous subunit Mft1 found in yeast. Mft1 is a component the THO subcomplex of the TREX complex, which operates in coupling tr... | [
"GO:0006397",
"GO:0000445"
] | [
"mRNA processing",
"THO complex part of transcription export complex"
] | [
"biological_process",
"cellular_component"
] | 2 | [
"PFAM"
] | [
"PF05615"
] | [
"THOC7"
] | [
4938
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-159236",
"R-BTA-72187",
"R-BTA-73856",
"R-DME-159236",
"R-DME-72187",
"R-DME-73856",
"R-HSA-159236",
"R-HSA-72187",
"R-HSA-73856",
"R-MMU-159236",
"R-MMU-72187",
"R-MMU-73856"
] | [
"REACTOME:R-BTA-159236",
"REACTOME:R-BTA-72187",
"REACTOME:R-BTA-73856",
"REACTOME:R-DME-159236",
"REACTOME:R-DME-72187",
"REACTOME:R-DME-73856",
"REACTOME:R-HSA-159236",
"REACTOME:R-HSA-72187",
"REACTOME:R-HSA-73856",
"REACTOME:R-MMU-159236",
"REACTOME:R-MMU-72187",
"REACTOME:R-MMU-73856"
] | 12 | [
"7apk",
"7apx",
"7aqo",
"7luv",
"7v2w",
"7v2y",
"7znk",
"7znl"
] | 8 | [
"PUB00044694",
"PUB00044998",
"PUB00045309",
"PUB00063151",
"PUB00063152",
"PUB00063153",
"PUB00063157"
] | [
"15133499",
"12093753",
"15998806",
"12871933",
"14527416",
"15192704",
"17190602"
] | [
"Genome-wide analysis of mRNAs regulated by the THO complex in Drosophila melanogaster.",
"The yeast THO complex and mRNA export factors link RNA metabolism with transcription and genome instability.",
"Recruitment of the human TREX complex to mRNA during splicing.",
"Molecular evidence that the eukaryotic TH... | [
2004,
2002,
2005,
2003,
2003,
2004,
2006
] | 7 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"marine sediment metagenome"
] | [
4937,
1
] | 2 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
6,
1,
1,
1,
3,
4,
1,
5,
7,
1,
1,
6
] | 12 | true | Family | THO complex subunit 7/Mft1 | THO complex subunit 7/Mft1 | THOC7/Mft1 | 4 |
IPR008502 | 8,502 | Prolamin-like domain | Prolamin-like | Domain | 7,491 | false | false | Proteins with this domain are found to be expressed in the plant embryo sac and are regulated by the Myb98 transcription factor. Computational analysis has revealed that they are homologous to the plant prolamin superfamily (Protease inhibitor-seed storage-LTP family, ) [ ]. In contrast to the typical prolamin members ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF05617"
] | [
"Prolamin_like"
] | [
7491
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00057502",
"PUB00057503"
] | [
"19806031",
"17937500"
] | [
"Homology between DUF784, DUF1278 domains and the plant prolamin superfamily typifies evolutionary changes of disulfide bonding patterns.",
"Genome-wide expression profiling of the Arabidopsis female gametophyte identifies families of small, secreted proteins."
] | [
2009,
2007
] | 2 | [] | [] | 0 | 0 | null | [
"Magnoliopsida"
] | [
7491
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
247,
10,
5
] | 3 | true | Domain | Prolamin-like domain | Prolamin-like domain | Prolamin-like | 6 |
IPR008503 | 8,503 | Retropepsin-like aspartic endopeptidase RimB | Asp_endopeptidase_RimB | Domain | 9,333 | false | false | This entry represents a domain found in retropepsin-like bacterial proteases such as RimB from Pseudomonas fluorescens and the related retropepsin-like osmotic stress tolerance peptidases (Rlo) from Pseudomonas aeruginosa [ , ]. RimB is involved in rhizosphere colonisation and plant infection. It is a bifunctional retr... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF05618"
] | [
"RimB-like"
] | [
9333
] | 1 | [
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC"... | [
"6.3.2.-",
"PWY-6289",
"PWY-6374",
"PWY-6378",
"PWY-6379",
"PWY-6409",
"PWY-6574",
"PWY-7510",
"PWY-7533",
"PWY-7542",
"PWY-7543",
"PWY-7549",
"PWY-7555",
"PWY-7556",
"PWY-7561",
"PWY-7563",
"PWY-7565",
"PWY-7569",
"PWY-7570",
"PWY-7571",
"PWY-7577",
"PWY-7600",
"PWY-7605... | [
"EC:6.3.2.-",
"METACYC:PWY-6289",
"METACYC:PWY-6374",
"METACYC:PWY-6378",
"METACYC:PWY-6379",
"METACYC:PWY-6409",
"METACYC:PWY-6574",
"METACYC:PWY-7510",
"METACYC:PWY-7533",
"METACYC:PWY-7542",
"METACYC:PWY-7543",
"METACYC:PWY-7549",
"METACYC:PWY-7555",
"METACYC:PWY-7556",
"METACYC:PWY-7... | 42 | [
"2pma",
"9g58",
"9g59"
] | 3 | [
"PUB00161732",
"PUB00161733"
] | [
"39978677",
"40166241"
] | [
"A retropepsin-like bacterial protease regulates ribosome modification and polypeptide production.",
"Secreted retropepsin-like enzymes are essential for stress tolerance and biofilm formation in <i>Pseudomonas aeruginosa</i>."
] | [
2025,
2025
] | 2 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
399,
8854,
10,
3,
67
] | 5 | [] | [] | 0 | true | Domain | Retropepsin-like aspartic endopeptidase RimB | Retropepsin-like aspartic endopeptidase RimB | Asp_endopeptidase_RimB | 7 |
IPR008504 | 8,504 | ER membrane protein complex subunit 6 | Emc6 | Family | 3,684 | false | false | This entry represents ER membrane protein complex subunit 6 (Emc6). Emc6 is a component of the ER membrane protein complex (EMC), which is composed of Emc1, Emc2, Emc3, Emc4, Emc5 and Emc6 in budding yeast [ ]. The EMC complex is required for efficient folding of proteins in the ER and enables the energy-independent in... | [
"GO:0005783",
"GO:0016020",
"GO:0072546"
] | [
"endoplasmic reticulum",
"membrane",
"EMC complex"
] | [
"cellular_component",
"cellular_component",
"cellular_component"
] | 3 | [
"PANTHER"
] | [
"PTHR20994"
] | [
""
] | [
3684
] | 1 | [] | [] | [] | 0 | [
"6wb9",
"6ww7",
"6z3w",
"7ado",
"7adp",
"7kra",
"7ktx",
"8eoi",
"8j0n",
"8j0o",
"8s9s",
"9c7v"
] | 12 | [
"PUB00061987",
"PUB00067575",
"PUB00096679",
"PUB00096681",
"PUB00096682"
] | [
"19325107",
"23431131",
"29809151",
"32459176",
"32439656"
] | [
"Comprehensive characterization of genes required for protein folding in the endoplasmic reticulum.",
"Biosynthesis of ionotropic acetylcholine receptors requires the evolutionarily conserved ER membrane complex.",
"The ER membrane protein complex interacts cotranslationally to enable biogenesis of multipass me... | [
2009,
2013,
2018,
2020,
2020
] | 5 | [
"IPR029008"
] | [] | 1 | 0 | 1 | [
"Eukaryota"
] | [
3684
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
5,
1,
1,
2,
1,
1,
1,
1,
3,
1,
1,
4
] | 12 | true | Family | ER membrane protein complex subunit 6 | ER membrane protein complex subunit 6 | Emc6 | 7 |
IPR008505 | 8,505 | Protein of unknown function DUF787 | DUF787 | Family | 175 | false | false | This entry consists of several hypothetical proteins of unknown function from Borrelia species. They may be proteinases, as the majority contain a propeptide proteinase inhibitor domain which is associated with both serine and metallopeptidases. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF05619"
] | [
"DUF787"
] | [
175
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Borreliaceae"
] | [
175
] | 1 | [] | [] | 0 | true | Family | Protein of unknown function DUF787 | Protein of unknown function DUF787 | DUF787 | 3 |
IPR008506 | 8,506 | SRP-independent targeting protein 2/TMEM208 | SND2/TMEM208 | Family | 4,337 | false | false | This family includes SRP-independent targeting protein 2 (SND2) from yeast and transmembrane protein 208 (TMEM208) from mammals. Both are localized to the endoplasmic reticulum (ER) [ , ]. SND2 works together with SND1 and SND3 in an alternative targeting route to the ER [ ]. TMEM208 regulates both ER stress and autoph... | [] | [] | [] | 0 | [
"PFAM",
"PANTHER"
] | [
"PF05620",
"PTHR13505"
] | [
"TMEM208_SND2",
""
] | [
4337,
4148
] | 2 | [] | [] | [] | 0 | [] | 0 | [
"PUB00044889",
"PUB00066964",
"PUB00083911",
"PUB00083915"
] | [
"16303567",
"21912603",
"27905431",
"23691174"
] | [
"A large-scale screen in S. pombe identifies seven novel genes required for critical meiotic events.",
"A genome-wide immunodetection screen in S. cerevisiae uncovers novel genes involved in lysosomal vacuole function and morphology.",
"The SND proteins constitute an alternative targeting route to the endoplasm... | [
2005,
2011,
2016,
2013
] | 4 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Latilactobacillus fuchuensis",
"freshwater metagenome"
] | [
4334,
2,
1
] | 3 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
9,
1,
1,
1,
3,
3,
1,
2,
6,
1,
1,
3
] | 12 | true | Family | SRP-independent targeting protein 2/TMEM208 | SRP-independent targeting protein 2/TMEM208 | SND2/TMEM208 | 4 |
IPR008507 | 8,507 | Protein of unknown function DUF789 | DUF789 | Family | 6,174 | false | false | This family consists of several plant proteins of unknown function. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF05623"
] | [
"DUF789"
] | [
6174
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
6174
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
70,
32,
115
] | 3 | true | Family | Protein of unknown function DUF789 | Protein of unknown function DUF789 | DUF789 | 1 |
IPR008508 | 8,508 | Endonuclease Bax1 | Bax1 | Family | 1,254 | false | false | This entry consists of several bacterial and archaeal endonuclease proteins that may be involved in either restriction-modification and/or DNA excision repair [ ]. Among its members is endonuclease Bax1 from archaea, a dual DNA endonuclease probably involved in nucleotide excision repair (NER) [ ]. The N-terminal nucle... | [] | [] | [] | 0 | [
"PFAM",
"PIRSF",
"PANTHER"
] | [
"PF05626",
"PIRSF019435",
"PTHR39640"
] | [
"DUF790",
"UCP019435",
""
] | [
1254,
995,
1242
] | 3 | [] | [] | [] | 0 | [
"6p4f",
"6p4o",
"6p4w",
"6p66",
"8gy8"
] | 5 | [
"PUB00020736",
"PUB00153767",
"PUB00153768"
] | [
"15972856",
"32374860",
"32986831"
] | [
"Identification of novel restriction endonuclease-like fold families among hypothetical proteins.",
"Structural basis of the XPB-Bax1 complex as a dynamic helicase-nuclease machinery for DNA repair.",
"Structural basis of the XPB helicase-Bax1 nuclease complex interacting with the repair bubble DNA."
] | [
2005,
2020,
2020
] | 3 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Protostomia",
"ecological metagenomes"
] | [
629,
605,
2,
18
] | 4 | [] | [] | 0 | true | Family | Endonuclease Bax1 | Endonuclease Bax1 | Bax1 | 2 |
IPR008509 | 8,509 | Molybdate-anion transporter | MOT2/MFSD5 | Family | 5,888 | false | false | This entry represents a group of molybdate-anion transporters, including MFSD5 (also known as hsMOT2) from humans and molybdate transporter (CrMOT2, ) from Chlamydomonas [ ]. They mediate high-affinity intracellular uptake of the rare oligo-element molybdenum. | [
"GO:0015098",
"GO:0015689",
"GO:0016020"
] | [
"molybdate ion transmembrane transporter activity",
"molybdate ion transport",
"membrane"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PFAM",
"PANTHER"
] | [
"PF05631",
"PTHR23516"
] | [
"MFS_5",
""
] | [
5657,
5763
] | 2 | [] | [] | [] | 0 | [] | 0 | [
"PUB00071813"
] | [
"21464289"
] | [
"Algae and humans share a molybdate transporter."
] | [
2011
] | 1 | [] | [] | 0 | 0 | null | [
"Alphaproteobacteria",
"Candidatus Acidianus copahuensis",
"Eukaryota"
] | [
10,
1,
5877
] | 3 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
24,
1,
7,
2,
1,
12,
3,
51
] | 8 | true | Family | Molybdate-anion transporter | Molybdate-anion transporter | MOT2/MFSD5 | 9 |
IPR008510 | 8,510 | Protein of unknown function DUF792, Borrelia species | DUF792_BOR_spp | Family | 157 | false | false | This entry consists of several hypothetical proteins found in Borrelia species. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF05632"
] | [
"DUF792"
] | [
157
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Borreliaceae"
] | [
157
] | 1 | [] | [] | 0 | true | Family | Protein of unknown function DUF792, Borrelia species | Protein of unknown function DUF792, Borrelia species | DUF792_BOR_spp | 9 |
IPR008511 | 8,511 | Protein ROH1-like | ROH1-like | Family | 3,571 | false | false | This entry includes a family of proteins such as protein BYPASS1-LIKE [ ], protein ROH1 [ ] and related proteins that are involved in the regulation of plant growth and development. ROH1 is an interactor of the exocyst subunit Exo70A1, and has been shown to be required for seed coat mucilage deposition [ ]. BYPASS1-LIK... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF05633"
] | [
"ROH1-like"
] | [
3571
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00093724",
"PUB00151119",
"PUB00151120",
"PUB00151121",
"PUB00151122"
] | [
"20618910",
"31297122",
"35249253",
"33519861",
"32664862"
] | [
"Arabidopsis exocyst subunits SEC8 and EXO70A1 and exocyst interactor ROH1 are involved in the localized deposition of seed coat pectin.",
"BYPASS1-LIKE, A DUF793 Family Protein, Participates in Freezing Tolerance <i>via</i> the CBF Pathway in <i>Arabidopsis</i>.",
"BYPASS1-LIKE regulates lateral root initiatio... | [
2010,
2019,
2022,
2020,
2020
] | 5 | [] | [] | 0 | 0 | null | [
"Embryophyta",
"Salmonella enterica I"
] | [
3570,
1
] | 2 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
23,
17,
21
] | 3 | true | Family | Protein ROH1-like | Protein ROH1-like | ROH1-like | 6 |
IPR008513 | 8,513 | tRNA(Met) cytidine acetate ligase | tRNA(Met)_cyd_acetate_ligase | Family | 5,663 | false | false | This entry represents the tRNA(Met) cytidine acetate ligase family of predominantly bacterial proteins. | [] | [] | [] | 0 | [
"HAMAP",
"PFAM",
"PANTHER"
] | [
"MF_01539",
"PF05636",
"PTHR37825"
] | [
"TmcAL",
"HIGH_NTase1",
""
] | [
5320,
5662,
5639
] | 3 | [
"EC"
] | [
"6.3.1.22"
] | [
"EC:6.3.1.22"
] | 1 | [
"3gmi",
"5y0n",
"5y0o",
"5y0p",
"5y0q",
"5y0r",
"5y0s",
"5y0t"
] | 8 | [
"PUB00091678"
] | [
"30150682"
] | [
"Acetate-dependent tRNA acetylation required for decoding fidelity in protein synthesis."
] | [
2018
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Methanomada group",
"metagenomes"
] | [
5513,
2,
89,
59
] | 4 | [] | [] | 0 | true | Family | tRNA(Met) cytidine acetate ligase | tRNA(Met) cytidine acetate ligase | tRNA(Met)_cyd_acetate_ligase | 6 |
IPR008514 | 8,514 | Type VI secretion system effector Hcp | T6SS_Hcp | Domain | 14,475 | false | false | This entry consists of Hcp-like proteins. Hcp is part of the type VI secretion system of Gram-negative bacteria. Hcp is not only a secreted effector protein, but also might act as machine component [ , , ]. Several bacterial pathogens mediate interactions with their hosts through protein secretion, often involving Hcp-... | [] | [] | [] | 0 | [
"PFAM",
"NCBIFAM"
] | [
"PF05638",
"TIGR03344"
] | [
"T6SS_HCP",
"VI_effect_Hcp1"
] | [
14427,
9970
] | 2 | [
"GP"
] | [
"GenProp0735"
] | [
"GP:GenProp0735"
] | 1 | [
"1y12",
"3eaa",
"3he1",
"3v4h",
"3wx6",
"4hkh",
"4ksr",
"4kss",
"4tv4",
"4w64",
"5mxn",
"5ojq",
"5urw",
"5xeu",
"5xhh",
"6a2v",
"6ap1",
"7fcf",
"7o42",
"8yun",
"8z7k"
] | 21 | [
"PUB00034462",
"PUB00054686",
"PUB00067803",
"PUB00067804",
"PUB00067810",
"PUB00067811",
"PUB00093972",
"PUB00093973",
"PUB00155386",
"PUB00160456"
] | [
"16763151",
"20886112",
"22753062",
"18617888",
"22184413",
"23519162",
"27288401",
"31379775",
"26079269",
"39546591"
] | [
"A virulence locus of Pseudomonas aeruginosa encodes a protein secretion apparatus.",
"Structural basis for the secretion of EvpC: a key type VI secretion system protein from Edwardsiella tarda.",
"Hcp2, a secreted protein of the phytopathogen Pseudomonas syringae pv. tomato DC3000, is required for fitness for ... | [
2006,
2010,
2012,
2008,
2012,
2013,
2016,
2019,
2015,
2024
] | 10 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Peduovirinae sp. ctjOQ18",
"unclassified sequences"
] | [
12,
14350,
60,
1,
52
] | 5 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Domain | Type VI secretion system effector Hcp | Type VI secretion system effector Hcp | T6SS_Hcp | 3 |
IPR008515 | 8,515 | Prokaryotic ubiquitin-like protein Pup | Ubiquitin-like_Pup | Family | 3,984 | false | false | This entry represents Prokaryotic ubiquitin-like protein Pup from Mycobacterium tuberculosis and similar short proteins, of 50-90 residues in length, predominantly found in Actinobacteria. Pup is covalently conjugated to the e-NH2 groups of lysines on several target proteins (pupylation) such as the malonyl CoA acyl ca... | [
"GO:0031386",
"GO:0070628",
"GO:0010498",
"GO:0019941",
"GO:0070490"
] | [
"protein tag activity",
"proteasome binding",
"proteasomal protein catabolic process",
"modification-dependent protein catabolic process",
"protein pupylation"
] | [
"molecular_function",
"molecular_function",
"biological_process",
"biological_process",
"biological_process"
] | 5 | [
"HAMAP",
"PFAM",
"NCBIFAM"
] | [
"MF_02106",
"PF05639",
"TIGR03687"
] | [
"Pup",
"Pup",
"pupylate_cterm"
] | [
3457,
3984,
3969
] | 3 | [
"GP"
] | [
"GenProp0833"
] | [
"GP:GenProp0833"
] | 1 | [
"3m91",
"3m9d",
"4bjr",
"7oxy",
"7oy3",
"7oyf",
"7oyh",
"7px9",
"7pxb",
"7pxc",
"7pxd",
"9cku"
] | 12 | [
"PUB00053382",
"PUB00053383",
"PUB00055264",
"PUB00100051"
] | [
"18980670",
"18832610",
"20953180",
"23601177"
] | [
"Unraveling the biochemistry and provenance of pupylation: a prokaryotic analog of ubiquitination.",
"Ubiquitin-like protein involved in the proteasome pathway of Mycobacterium tuberculosis.",
"Binding-induced folding of prokaryotic ubiquitin-like protein on the Mycobacterium proteasomal ATPase targets substrat... | [
2008,
2008,
2010,
2013
] | 4 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
3906,
3,
75
] | 3 | [] | [] | 0 | true | Family | Prokaryotic ubiquitin-like protein Pup | Prokaryotic ubiquitin-like protein Pup | Ubiquitin-like_Pup | 5 |
IPR008516 | 8,516 | Na,K-Atpase Interacting protein | Na/K-Atpase_Interacting | Family | 4,762 | false | false | NKAIN (Na,K-Atpase INteracting) proteins are a family of evolutionary conserved transmembrane proteins that localise to neurons, that are critical for neuronal function, and that interact with the beta subunits, beta1 in vertebrates and beta in Drosophila, of Na,K-ATPase. NKAINs have highly conserved trans-membrane dom... | [] | [] | [] | 0 | [
"PFAM",
"PANTHER"
] | [
"PF05640",
"PTHR13084"
] | [
"NKAIN",
""
] | [
4759,
4700
] | 2 | [] | [] | [] | 0 | [] | 0 | [
"PUB00044756"
] | [
"17606467"
] | [
"A novel family of transmembrane proteins interacting with beta subunits of the Na,K-ATPase."
] | [
2007
] | 1 | [] | [] | 0 | 0 | null | [
"Opisthokonta"
] | [
4762
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
6,
7,
21,
11,
23
] | 6 | true | Family | Na,K-Atpase Interacting protein | Na,K-Atpase Interacting protein | Na/K-Atpase_Interacting | 4 |
IPR008517 | 8,517 | Putative lipoprotein GNA1162-like | GNA1162-like | Family | 1,787 | false | false | This entry represents a family of putative lipoproteins predominantly found in Proteobacteria, including GNA1162 from Neisseria meningitidis ( ). This protein shows five α-helices and four β-strands, three of them forming a β-sheet [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF05643"
] | [
"GNA1162-like"
] | [
1787
] | 1 | [] | [] | [] | 0 | [
"4hrv"
] | 1 | [
"PUB00101016"
] | [
"23545639"
] | [
"Structure of Neisseria meningitidis lipoprotein GNA1162."
] | [
2013
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Opisthokonta",
"metagenomes"
] | [
1750,
4,
33
] | 3 | [] | [] | 0 | true | Family | Putative lipoprotein GNA1162-like | Putative lipoprotein GNA1162-like | GNA1162-like | 4 |
IPR008519 | 8,519 | Tandem-repeating region of mucin, epiglycanin-like | Tandem-repeating_mucin | Domain | 115 | false | false | The unusual mucin, epiglycanin, is membrane-bound at the C terminus but has a long region of this tandem-repeat at the N terminus [ ]. It was the first mucin identified to be associated with the malignant behaviour of carcinoma cells [ ]. Mouse Muc21/epiglycanin is thought to be a highly glycosylated molecule, which ma... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF05647"
] | [
"Epiglycanin_TR"
] | [
115
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-5083625",
"R-HSA-5083632",
"R-HSA-5083636",
"R-HSA-5621480",
"R-HSA-913709",
"R-HSA-977068"
] | [
"REACTOME:R-HSA-5083625",
"REACTOME:R-HSA-5083632",
"REACTOME:R-HSA-5083636",
"REACTOME:R-HSA-5621480",
"REACTOME:R-HSA-913709",
"REACTOME:R-HSA-977068"
] | 6 | [] | 0 | [
"PUB00066740",
"PUB00066741",
"PUB00066742"
] | [
"17977904",
"18925876",
"20388707"
] | [
"Identification and expression of human epiglycanin/MUC21: a novel transmembrane mucin.",
"Ligation of tumour-produced mucins to CD22 dramatically impairs splenic marginal zone B-cells.",
"Mucin 21/epiglycanin modulates cell adhesion."
] | [
2008,
2009,
2010
] | 3 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
115
] | 1 | [
"Caenorhabditis elegans",
"Homo sapiens"
] | [
1,
17
] | 2 | true | Domain | Tandem-repeating region of mucin, epiglycanin-like | Tandem-repeating region of mucin, epiglycanin-like | Tandem-repeating_mucin | 9 |
IPR008520 | 8,520 | Domain of unknown function DUF802 | DUF802 | Domain | 954 | false | false | This region is found as two or more repeats in a small number of hypothetical proteins. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF05650"
] | [
"DUF802"
] | [
954
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Knufia peltigerae",
"metagenomes"
] | [
944,
1,
9
] | 3 | [] | [] | 0 | true | Domain | Domain of unknown function DUF802 | Domain of unknown function DUF802 | DUF802 | 6 |
IPR008523 | 8,523 | Protein of unknown function DUF805 | DUF805 | Family | 15,696 | false | false | This family consists of several bacterial proteins of unknown function. | [
"GO:0016020"
] | [
"membrane"
] | [
"cellular_component"
] | 1 | [
"PFAM",
"PANTHER"
] | [
"PF05656",
"PTHR34980"
] | [
"DUF805",
""
] | [
15693,
13973
] | 2 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Caudoviricetes",
"Eukaryota",
"Methanobacteriati",
"unclassified sequences"
] | [
15419,
3,
13,
22,
239
] | 5 | [
"Escherichia coli (strain K12)"
] | [
3
] | 1 | true | Family | Protein of unknown function DUF805 | Protein of unknown function DUF805 | DUF805 | 7 |
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