interpro_id string | interpro_numeric_id int64 | name string | short_name string | entry_type string | protein_count int64 | is_llm bool | is_llm_reviewed bool | abstract string | go_ids list | go_terms list | go_categories list | go_count int64 | member_databases list | member_accessions list | member_names list | member_protein_counts list | member_count int64 | external_databases list | external_accessions list | external_xrefs list | external_xref_count int64 | pdb_ids list | structure_count int64 | publication_ids list | pubmed_ids list | publication_titles list | publication_years list | publication_count int64 | parent_ids list | child_ids list | parent_count int64 | child_count int64 | tree_depth float64 | taxonomy_names list | taxonomy_protein_counts list | taxonomy_count int64 | key_species_names list | key_species_protein_counts list | key_species_count int64 | in_entry_list bool | entry_list_type string | entry_list_name string | names_dat_name string | short_names_dat_name string | split_bucket int64 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
IPR008280 | 8,280 | Tubulin/FtsZ, C-terminal | Tub_FtsZ_C | Homologous_superfamily | 101,891 | false | false | This domain superfamily is found in the tubulin alpha, beta and gamma chains, as well as the bacterial FtsZ family of proteins. These proteins are GTPases and are involved in polymer formation. Tubulin is the major component of microtubules, while FtsZ is the polymer-forming protein of bacterial cell division, it is pa... | [] | [] | [] | 0 | [
"SSF"
] | [
"SSF55307"
] | [
""
] | [
101891
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-114608",
"R-BTA-190840",
"R-BTA-2132295",
"R-BTA-2467813",
"R-BTA-2500257",
"R-BTA-2565942",
"R-BTA-3371497",
"R-BTA-380259",
"R-BTA-380270",
"R-BTA-380284",
"R-BTA-380320",
"R-BTA-5610787",
"R-BTA-5617833",
"R-BTA-5620912",
"R-BTA-5620924",
"R-BTA-5626467",
"R-BTA-5663220",
... | [
"REACTOME:R-BTA-114608",
"REACTOME:R-BTA-190840",
"REACTOME:R-BTA-2132295",
"REACTOME:R-BTA-2467813",
"REACTOME:R-BTA-2500257",
"REACTOME:R-BTA-2565942",
"REACTOME:R-BTA-3371497",
"REACTOME:R-BTA-380259",
"REACTOME:R-BTA-380270",
"REACTOME:R-BTA-380284",
"REACTOME:R-BTA-380320",
"REACTOME:R-BT... | 233 | [
"1ffx",
"1fsz",
"1ia0",
"1jff",
"1ofu",
"1rlu",
"1rq2",
"1rq7",
"1sa0",
"1sa1",
"1tub",
"1tvk",
"1w58",
"1w59",
"1w5a",
"1w5b",
"1w5e",
"1w5f",
"1z2b",
"1z5v",
"1z5w",
"2bto",
"2btq",
"2hxf",
"2hxh",
"2p4n",
"2q1x",
"2q1y",
"2r6r",
"2r75",
"2rhh",
"2rhj"... | 877 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Siphoviridae sp. ctBLh2",
"unclassified sequences"
] | [
1501,
28555,
71153,
1,
681
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
60,
20,
36,
30,
1,
100,
43,
4,
44,
74,
4,
4,
185
] | 13 | true | Homologous_superfamily | Tubulin/FtsZ, C-terminal | Tubulin/FtsZ, C-terminal | Tub_FtsZ_C | 7 |
IPR008283 | 8,283 | Peptidase M17, leucyl aminopeptidase, N-terminal | Peptidase_M17_N | Domain | 23,314 | false | false | This group of metallopeptidases belong to the MEROPS peptidase family M17 (leucyl aminopeptidase family, clan MF), the type example being leucyl aminopeptidase from Bos taurus (Bovine). Over 70 metallopeptidase families have been identified to date. In these enzymes a divalent cation, which is usually zinc but may be c... | [
"GO:0070006",
"GO:0006508"
] | [
"metalloaminopeptidase activity",
"proteolysis"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PFAM"
] | [
"PF02789"
] | [
"Peptidase_M17_N"
] | [
23314
] | 1 | [
"EC",
"EC",
"GP"
] | [
"3.4.11.1",
"3.4.11.10",
"GenProp1664"
] | [
"EC:3.4.11.1",
"EC:3.4.11.10",
"GP:GenProp1664"
] | 3 | [
"1bll",
"1bpm",
"1bpn",
"1gyt",
"1lam",
"1lan",
"1lap",
"1lcp",
"2ewb",
"2j9a",
"3h8e",
"3h8f",
"3h8g",
"3jru",
"3kzw",
"3pei",
"4ksi",
"4zi6",
"4zla",
"5d8n",
"5lhj",
"5lhk",
"6ome",
"7y1s",
"8d1x",
"8pz0",
"8pzm",
"8pzy"
] | 28 | [
"PUB00001416",
"PUB00003579",
"PUB00004713"
] | [
"1555602",
"7674922",
"2395881"
] | [
"Leucine aminopeptidase from Arabidopsis thaliana. Molecular evidence for a phylogenetically conserved enzyme of protein turnover in higher plants.",
"Evolutionary families of metallopeptidases.",
"Molecular structure of leucine aminopeptidase at 2.7-A resolution."
] | [
1992,
1995,
1990
] | 3 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
75,
18640,
4076,
523
] | 4 | [
"Arabidopsis thaliana",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)",
"Zea mays"
] | [
14,
1,
9,
1,
2,
1,
3,
4,
1,
13
] | 10 | true | Domain | Peptidase M17, leucyl aminopeptidase, N-terminal | Peptidase M17, leucyl aminopeptidase, N-terminal | Peptidase_M17_N | 8 |
IPR008286 | 8,286 | Orn/Lys/Arg decarboxylase, C-terminal | Prn/Lys/Arg_de-COase_C | Domain | 19,996 | false | false | Pyridoxal-dependent decarboxylases are bacterial proteins acting on ornithine, lysine, arginine and related substrates [ ]. One of the regions of sequence similarity contains a conserved lysine residue, which is the site of attachment of the pyridoxal-phosphate group. Ornithine decarboxylase is a dodecamer composed of ... | [
"GO:0003824"
] | [
"catalytic activity"
] | [
"molecular_function"
] | 1 | [
"PFAM"
] | [
"PF03711"
] | [
"OKR_DC_1_C"
] | [
19996
] | 1 | [
"EC",
"GP",
"GP",
"GP"
] | [
"4.1.1",
"GenProp1279",
"GenProp1433",
"GenProp1596"
] | [
"EC:4.1.1",
"GP:GenProp1279",
"GP:GenProp1433",
"GP:GenProp1596"
] | 4 | [
"1c4k",
"1ord",
"2vyc",
"2x3l",
"3n75",
"3q16",
"4upb",
"4upf",
"5fkx",
"5fkz",
"5fl2",
"5xx1",
"6q6i",
"6q7l",
"6q7m",
"6y3x",
"6yn5",
"6yn6",
"7p9b",
"7pk6",
"9e0m",
"9e0o",
"9e0q"
] | 23 | [
"PUB00001452",
"PUB00006301",
"PUB00006322",
"PUB00006531",
"PUB00014378",
"PUB00014382",
"PUB00014393",
"PUB00016775",
"PUB00016898",
"PUB00035507",
"PUB00070977",
"PUB00079513",
"PUB00079514",
"PUB00079515"
] | [
"8181483",
"8112347",
"7748903",
"10800595",
"7663340",
"9405048",
"9063963",
"10223296",
"9914259",
"17109392",
"10673430",
"10586514",
"17504214",
"11933250"
] | [
"Multiple evolutionary origin of pyridoxal-5'-phosphate-dependent amino acid decarboxylases.",
"Evolutionary relationships among pyridoxal-5'-phosphate-dependent enzymes. Regio-specific alpha, beta and gamma families.",
"Pyridoxal phosphate-dependent enzymes.",
"The molecular evolution of pyridoxal-5'-phospha... | [
1994,
1994,
1995,
2000,
1995,
1997,
1996,
1999,
1998,
2006,
2000,
1999,
2007,
2001
] | 14 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
48,
18905,
848,
195
] | 4 | [
"Escherichia coli (strain K12)",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
5,
5,
6
] | 3 | true | Domain | Orn/Lys/Arg decarboxylase, C-terminal | Orn/Lys/Arg decarboxylase, C-terminal | Prn/Lys/Arg_de-COase_C | 7 |
IPR008288 | 8,288 | Poly [ADP-ribose] polymerase | PARP | Family | 1,683 | false | false | Poly(ADP-ribose) synthase and poly(ADP-ribose) polymerase (PARP, also known as ADPRT) catalyse the DNA-dependent covalent attachment of ADP-ribose to various nuclear proteins [ ]. They are used by the eukaryotic cell to cope with numerous environmental and endogenous genotoxic agents that cause DNA strand breaks. PARP ... | [
"GO:0003677",
"GO:0003950",
"GO:0008270",
"GO:0051287",
"GO:0005634"
] | [
"DNA binding",
"NAD+ poly-ADP-ribosyltransferase activity",
"zinc ion binding",
"NAD binding",
"nucleus"
] | [
"molecular_function",
"molecular_function",
"molecular_function",
"molecular_function",
"cellular_component"
] | 5 | [
"PIRSF"
] | [
"PIRSF000489"
] | [
"NAD_ADPRT"
] | [
1683
] | 1 | [
"EC",
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"... | [
"2.4.2.-",
"2.4.2.30",
"PWY-5381",
"PWY-5800",
"PWY-6148",
"PWY-6720",
"PWY-7018",
"PWY-7025",
"PWY-7450",
"PWY-7817",
"PWY-7981",
"R-CEL-5696394",
"R-CEL-5696395",
"R-CEL-5696400",
"R-DME-110362",
"R-DME-2173795",
"R-DME-3108214",
"R-DME-5685939",
"R-DME-5696394",
"R-DME-56963... | [
"EC:2.4.2.-",
"EC:2.4.2.30",
"METACYC:PWY-5381",
"METACYC:PWY-5800",
"METACYC:PWY-6148",
"METACYC:PWY-6720",
"METACYC:PWY-7018",
"METACYC:PWY-7025",
"METACYC:PWY-7450",
"METACYC:PWY-7817",
"METACYC:PWY-7981",
"REACTOME:R-CEL-5696394",
"REACTOME:R-CEL-5696395",
"REACTOME:R-CEL-5696400",
"... | 48 | [] | 0 | [
"PUB00001533",
"PUB00003624",
"PUB00011133",
"PUB00011134"
] | [
"9034168",
"3118181",
"11781113",
"6088227"
] | [
"A superfamily of conserved domains in DNA damage-responsive cell cycle checkpoint proteins.",
"ADP-ribosylation of proteins. Enzymology and biological significance.",
"Poly(ADP-ribose) polymerase: a guardian angel protecting the genome and suppressing tumorigenesis.",
"Poly(ADP-ribose) polymerase is a zinc m... | [
1997,
1987,
2001,
1984
] | 4 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1683
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
5,
1,
2,
1,
4,
8,
1,
2,
2
] | 9 | true | Family | Poly [ADP-ribose] polymerase | Poly [ADP-ribose] polymerase | PARP | 7 |
IPR008289 | 8,289 | Pentafunctional AroM protein | Pentafunct_AroM | Family | 1,716 | false | false | Each member of this group contains five functional domains catalysing five sequential steps of the shikimate pathway. Each domain corresponds to a monofunctional prokaryotic enzyme of the same pathway: 3-dehydroquinate synthase, 3-dehydroquinate dehydratase, shikimate 5-dehydrogenase, shikimate kinase, and 3-phosphoshi... | [
"GO:0003855",
"GO:0003856",
"GO:0003866",
"GO:0004764",
"GO:0004765",
"GO:0009073"
] | [
"3-dehydroquinate dehydratase activity",
"3-dehydroquinate synthase activity",
"3-phosphoshikimate 1-carboxyvinyltransferase activity",
"shikimate 3-dehydrogenase (NADP+) activity",
"shikimate kinase activity",
"aromatic amino acid family biosynthetic process"
] | [
"molecular_function",
"molecular_function",
"molecular_function",
"molecular_function",
"molecular_function",
"biological_process"
] | 6 | [
"HAMAP",
"PIRSF"
] | [
"MF_03143",
"PIRSF000514"
] | [
"Pentafunct_AroM",
"Pentafunct_AroM"
] | [
1651,
1634
] | 2 | [
"EC",
"EC",
"EC",
"EC",
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC"
] | [
"1.1.1.25",
"2.5.1.19",
"2.7.1.71",
"4.2.1.10",
"4.2.3.4",
"PWY-6163",
"PWY-6164",
"PWY-6416",
"PWY-6707"
] | [
"EC:1.1.1.25",
"EC:2.5.1.19",
"EC:2.7.1.71",
"EC:4.2.1.10",
"EC:4.2.3.4",
"METACYC:PWY-6163",
"METACYC:PWY-6164",
"METACYC:PWY-6416",
"METACYC:PWY-6707"
] | 9 | [
"6hqv",
"7u5s",
"7u5t",
"7u5u"
] | 4 | [
"PUB00011136"
] | [
"2848727"
] | [
"The Saccharomyces cerevisiae ARO1 gene. An example of the co-ordinate regulation of five enzymes on a single biosynthetic pathway."
] | [
1988
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1716
] | 1 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
1,
1,
1
] | 3 | true | Family | Pentafunctional AroM protein | Pentafunctional AroM protein | Pentafunct_AroM | 8 |
IPR008290 | 8,290 | Phosphatidylinositol 3-kinase, Vps34 type | PI3K_Vps34 | Family | 4,699 | false | false | Members of this family are Class III phosphatidylinositol 3-kinases (PI3Ks) (catalytic subunits). PI3K is a lipid kinase and a key signaling enzyme involved in cell survival and proliferation, cell motility and adhesion, cytoskeletal rearrangement and vesicle trafficking [ ]. The different PI3K isoforms have cell-speci... | [
"GO:0016303",
"GO:0046854"
] | [
"1-phosphatidylinositol-3-kinase activity",
"phosphatidylinositol phosphate biosynthetic process"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PIRSF"
] | [
"PIRSF000587"
] | [
"PI3K_Vps34"
] | [
4699
] | 1 | [
"EC",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"... | [
"2.7.1.137",
"PWY-6352",
"R-CEL-1632852",
"R-CEL-1660514",
"R-CEL-1660516",
"R-CEL-1660517",
"R-CEL-5668599",
"R-DDI-1632852",
"R-DDI-1660514",
"R-DDI-1660516",
"R-DDI-1660517",
"R-DDI-5668599",
"R-HSA-109704",
"R-HSA-1632852",
"R-HSA-1660514",
"R-HSA-1660516",
"R-HSA-1660517",
"R-... | [
"EC:2.7.1.137",
"METACYC:PWY-6352",
"REACTOME:R-CEL-1632852",
"REACTOME:R-CEL-1660514",
"REACTOME:R-CEL-1660516",
"REACTOME:R-CEL-1660517",
"REACTOME:R-CEL-5668599",
"REACTOME:R-DDI-1632852",
"REACTOME:R-DDI-1660514",
"REACTOME:R-DDI-1660516",
"REACTOME:R-DDI-1660517",
"REACTOME:R-DDI-5668599"... | 47 | [
"2x6f",
"2x6h",
"2x6i",
"2x6j",
"2x6k",
"3ls8",
"4ph4",
"5dfz",
"5enn",
"5kc2",
"6i3u",
"6ykg",
"7bl1",
"8sor",
"9c82",
"9mhf",
"9mhg",
"9mhh"
] | 18 | [
"PUB00001709",
"PUB00005166",
"PUB00007087",
"PUB00011140",
"PUB00011141",
"PUB00011142"
] | [
"9247130",
"8385367",
"12151228",
"10579926",
"7628435",
"8719881"
] | [
"Using structure to define the function of phosphoinositide 3-kinase family members.",
"Phosphatidylinositol 3-kinase encoded by yeast VPS34 gene essential for protein sorting.",
"Structural insight into substrate specificity and regulatory mechanisms of phosphoinositide 3-kinases.",
"Signaling by distinct cl... | [
1997,
1993,
2002,
1999,
1995,
1995
] | 6 | [
"IPR015433"
] | [] | 1 | 0 | 1 | [
"Eukaryota"
] | [
4699
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
5,
1,
2,
2,
6,
3,
1,
5,
5,
1,
1,
7
] | 12 | true | Family | Phosphatidylinositol 3-kinase, Vps34 type | Phosphatidylinositol 3-kinase, Vps34 type | PI3K_Vps34 | 2 |
IPR008291 | 8,291 | Glucoamylase, starch-binding | Glucoamylase_SBD | Family | 1,613 | false | false | Glucoamylase (GA), also known as glucan 1,4-alpha-glucosidase, which belongs to family 15 ( ) in the classification of glycosyl hydrolases. GA catalyses the release of D-glucose from the non-reducing ends of starch and other oligo- or poly-saccharides. Studies of fungal GA have indicated 3 closely-clustered acidic resi... | [
"GO:0004339",
"GO:2001070",
"GO:0000272"
] | [
"glucan 1,4-alpha-glucosidase activity",
"starch binding",
"polysaccharide catabolic process"
] | [
"molecular_function",
"molecular_function",
"biological_process"
] | 3 | [
"PIRSF"
] | [
"PIRSF001031"
] | [
"Glu-a-glcsd_SBD"
] | [
1613
] | 1 | [
"EC",
"METACYC"
] | [
"3.2.1.3",
"PWY-5941"
] | [
"EC:3.2.1.3",
"METACYC:PWY-5941"
] | 2 | [
"2vn4",
"2vn7",
"6fhv",
"6fhw",
"6frv"
] | 5 | [
"PUB00001422",
"PUB00004952"
] | [
"1633799",
"1970434"
] | [
"Molecular cloning of a glucoamylase gene from a thermophilic Clostridium and kinetics of the cloned enzyme.",
"Catalytic mechanism of fungal glucoamylase as defined by mutagenesis of Asp176, Glu179 and Glu180 in the enzyme from Aspergillus awamori."
] | [
1992,
1990
] | 2 | [
"IPR000165"
] | [] | 1 | 0 | 1 | [
"Fungi"
] | [
1613
] | 1 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)"
] | [
1
] | 1 | true | Family | Glucoamylase, starch-binding | Glucoamylase, starch-binding | Glucoamylase_SBD | 8 |
IPR008292 | 8,292 | Haptoglobin | Haptoglobin | Family | 326 | false | false | Haptoglobin is a plasma protein that binds haemoglobin. The resulting complex is too large to be excreted by the kidney, thereby preventing loss of iron and damage to the kidney. The haptoglobin-haemoglobin complex is degraded in the liver, which is also the site of haptoglobin synthesis. The mature haptoglobin molecul... | [
"GO:0030492",
"GO:0005576"
] | [
"hemoglobin binding",
"extracellular region"
] | [
"molecular_function",
"cellular_component"
] | 2 | [
"PIRSF"
] | [
"PIRSF001137"
] | [
"Haptoglobin"
] | [
326
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-2168880",
"R-MMU-2168880",
"R-MMU-6798695",
"R-RNO-2168880",
"R-RNO-6798695",
"R-SSC-2168880",
"R-SSC-6798695"
] | [
"REACTOME:R-HSA-2168880",
"REACTOME:R-MMU-2168880",
"REACTOME:R-MMU-6798695",
"REACTOME:R-RNO-2168880",
"REACTOME:R-RNO-6798695",
"REACTOME:R-SSC-2168880",
"REACTOME:R-SSC-6798695"
] | 7 | [
"4f4o",
"4wjg",
"8xmp",
"8xmq",
"8xmw",
"9fmu",
"9hej",
"9hek",
"9nb6"
] | 9 | [
"PUB00011145",
"PUB00011146",
"PUB00011147",
"PUB00089999"
] | [
"3170608",
"2987228",
"8001969",
"21248165"
] | [
"Complex events in the evolution of the haptoglobin gene cluster in primates.",
"Nucleotide sequence of the haptoglobin and haptoglobin-related gene pair. The haptoglobin-related gene contains a retrovirus-like element.",
"Parallel evolutionary events in the haptoglobin gene clusters of rhesus monkey and human.... | [
1988,
1985,
1994,
2011
] | 4 | [
"IPR001314"
] | [] | 1 | 0 | 1 | [
"Bilateria"
] | [
326
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
2,
6
] | 3 | true | Family | Haptoglobin | Haptoglobin | Haptoglobin | 8 |
IPR008294 | 8,294 | Meprin alpha/beta subunit | Meprin | Family | 1,426 | false | false | Meprins are metazoan zinc metallopeptidases belonging to MEROPS peptidase family M12 (clan MA(M)), subfamily M12A (astacin family). They are complex and structurally unique homo- or heterotetrameric glycoproteins composed of evolutionarily related alpha and/or beta subunits that contain disulphide-bridged dimers. The t... | [
"GO:0004222",
"GO:0008270",
"GO:0006508",
"GO:0016020"
] | [
"metalloendopeptidase activity",
"zinc ion binding",
"proteolysis",
"membrane"
] | [
"molecular_function",
"molecular_function",
"biological_process",
"cellular_component"
] | 4 | [
"PIRSF"
] | [
"PIRSF001196"
] | [
"Meprin"
] | [
1426
] | 1 | [
"EC"
] | [
"3.4.24"
] | [
"EC:3.4.24"
] | 1 | [] | 0 | [
"PUB00005025",
"PUB00005405",
"PUB00006426",
"PUB00071087",
"PUB00071089"
] | [
"7670368",
"8387703",
"9857066",
"23427141",
"21693781"
] | [
"The astacin family of metalloendopeptidases.",
"An adhesive domain detected in functionally diverse receptors.",
"Role of the COOH-terminal domains of meprin A in folding, secretion, and activity of the metalloendopeptidase.",
"Meprin A metalloproteinase and its role in acute kidney injury.",
"Proteomic an... | [
1995,
1993,
1998,
2013,
2011
] | 5 | [] | [] | 0 | 0 | null | [
"Gnathostomata"
] | [
1426
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
4,
4,
3,
6
] | 4 | true | Family | Meprin alpha/beta subunit | Meprin alpha/beta subunit | Meprin | 2 |
IPR008296 | 8,296 | Tissue factor pathway inhibitor-like | TFPI-like | Family | 1,581 | false | false | Tissue factor pathway inhibitor (TFPI or TFPI1), also called lipoprotein-associated coagulation inhibitor (LACI) or extrinsic pathway inhibitor, is an anti-coagulation plasma protein that acts as a Kunitz-type serine protease inhibitor. Though TFPI lacks a membrane attachment signal, it remains associated with the endo... | [
"GO:0030414",
"GO:0010466",
"GO:0005576"
] | [
"peptidase inhibitor activity",
"negative regulation of peptidase activity",
"extracellular region"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PIRSF"
] | [
"PIRSF001620"
] | [
"TFPI"
] | [
1581
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-140834",
"R-HSA-9925563",
"R-MMU-140834",
"R-RNO-140834"
] | [
"REACTOME:R-HSA-140834",
"REACTOME:R-HSA-9925563",
"REACTOME:R-MMU-140834",
"REACTOME:R-RNO-140834"
] | 4 | [
"4bd9",
"7v1n"
] | 2 | [
"PUB00033197",
"PUB00033202",
"PUB00033203",
"PUB00086369"
] | [
"16261634",
"16689766",
"16411383",
"23746805"
] | [
"Tissue factor pathway inhibitor: structure, biology and involvement in disease.",
"A GPI-anchored co-receptor for tissue factor pathway inhibitor controls its intracellular trafficking and cell surface expression.",
"Structure, function and biology of tissue factor pathway inhibitor-2.",
"A noncanonical mech... | [
2006,
2006,
2005,
2013
] | 4 | [] | [] | 0 | 0 | null | [
"Bilateria"
] | [
1581
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
9,
8,
7
] | 4 | true | Family | Tissue factor pathway inhibitor-like | Tissue factor pathway inhibitor-like | TFPI-like | 6 |
IPR008297 | 8,297 | Notch | Notch | Family | 4,477 | false | false | Notch cell surface receptors are large, single-pass type-1 transmembrane proteins found in a diverse range of metazoan species, from human to Caenorhabditis species. The fruit fly, Drosophila melanogaster, possesses only one Notch protein, whereas in C.elegans, two receptors have been found; by contrast, four Notch par... | [
"GO:0007219",
"GO:0030154",
"GO:0050793",
"GO:0016020"
] | [
"Notch signaling pathway",
"cell differentiation",
"regulation of developmental process",
"membrane"
] | [
"biological_process",
"biological_process",
"biological_process",
"cellular_component"
] | 4 | [
"PIRSF"
] | [
"PIRSF002279"
] | [
"Notch"
] | [
4477
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-HSA-1912399",
"R-HSA-1912408",
"R-HSA-1912420",
"R-HSA-210744",
"R-HSA-2122947",
"R-HSA-2122948",
"R-HSA-2197563",
"R-HSA-2644606",
"R-HSA-2644607",
"R-HSA-2660826",
"R-HSA-2691232",
"R-HSA-2894862",
"R-HSA-2979096",
"R-HSA-350054",
"R-HSA-5083630",
"R-HSA-8941856",
"R-HSA-9013507... | [
"REACTOME:R-HSA-1912399",
"REACTOME:R-HSA-1912408",
"REACTOME:R-HSA-1912420",
"REACTOME:R-HSA-210744",
"REACTOME:R-HSA-2122947",
"REACTOME:R-HSA-2122948",
"REACTOME:R-HSA-2197563",
"REACTOME:R-HSA-2644606",
"REACTOME:R-HSA-2644607",
"REACTOME:R-HSA-2660826",
"REACTOME:R-HSA-2691232",
"REACTOME... | 45 | [] | 0 | [
"PUB00013432",
"PUB00053622",
"PUB00053623",
"PUB00053624",
"PUB00053625",
"PUB00053626",
"PUB00053638"
] | [
"10221902",
"19379690",
"12354787",
"11101851",
"12668592",
"16429119",
"10206645"
] | [
"Notch signaling: cell fate control and signal integration in development.",
"The canonical Notch signaling pathway: unfolding the activation mechanism.",
"The disintegrin/metalloprotease ADAM 10 is essential for Notch signalling but not for alpha-secretase activity in fibroblasts.",
"MAML1, a human homologue... | [
1999,
2009,
2002,
2000,
2003,
2006,
1999
] | 7 | [] | [
"IPR022331",
"IPR022336",
"IPR022355",
"IPR022362"
] | 0 | 4 | 0 | [
"Eumetazoa"
] | [
4477
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
7,
2,
32,
5,
17
] | 5 | true | Family | Notch | Notch | Notch | 6 |
IPR008299 | 8,299 | Prephenate dehydrogenase/arogenate dehydrogenase | Prep_DH/arog_DH | Family | 160 | false | false | Members of this group catalyse a step in tyrosine biosynthesis in the shikimate pathway, which is present only in bacteria, fungi, and plants. They contain both a prephenate dehydrogenase domain (PDH) and a regulatory domain. | [] | [] | [] | 0 | [
"NCBIFAM",
"PIRSF"
] | [
"NF006408",
"PIRSF006549"
] | [
"PRK08655.1-2",
"PDH_arog_dh_reg"
] | [
118,
132
] | 2 | [] | [] | [] | 0 | [] | 0 | [
"PUB00011045",
"PUB00011066"
] | [
"9843375",
"11450855"
] | [
"Use of site-directed mutagenesis to identify residues specific for each reaction catalyzed by chorismate mutase-prephenate dehydrogenase from Escherichia coli.",
"A metabolic node in action: chorismate-utilizing enzymes in microorganisms."
] | [
1998,
2001
] | 2 | [] | [] | 0 | 0 | null | [
"Methanobacteriota",
"bioreactor metagenome"
] | [
159,
1
] | 2 | [] | [] | 0 | true | Family | Prephenate dehydrogenase/arogenate dehydrogenase | Prephenate dehydrogenase/arogenate dehydrogenase | Prep_DH/arog_DH | 3 |
IPR008300 | 8,300 | Phosphate propanoyltransferase | PTAC | Family | 4,152 | false | false | This family includes phosphotransacylases (PTACs) required for the degradation of 1,2-propanediol (1,2-PD) [ ]. | [
"GO:0016747"
] | [
"acyltransferase activity, transferring groups other than amino-acyl groups"
] | [
"molecular_function"
] | 1 | [
"NCBIFAM",
"PFAM",
"PIRSF",
"PANTHER"
] | [
"NF011652",
"PF06130",
"PIRSF010130",
"PTHR39453"
] | [
"PRK15070.1",
"PTAC",
"PduL",
""
] | [
3998,
4152,
3556,
4024
] | 4 | [
"EC",
"GP",
"GP",
"METACYC",
"METACYC"
] | [
"2.3.1.222",
"GenProp0292",
"GenProp1762",
"PWY-5437",
"PWY-7013"
] | [
"EC:2.3.1.222",
"GP:GenProp0292",
"GP:GenProp1762",
"METACYC:PWY-5437",
"METACYC:PWY-7013"
] | 5 | [
"5cuo",
"5cup"
] | 2 | [
"PUB00075709",
"PUB00104965"
] | [
"17158662",
"25962918"
] | [
"PduL is an evolutionarily distinct phosphotransacylase involved in B12-dependent 1,2-propanediol degradation by Salmonella enterica serovar typhimurium LT2.",
"The PduL Phosphotransacylase Is Used To Recycle Coenzyme A within the Pdu Microcompartment."
] | [
2007,
2015
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Caudovirales sp. gcode 4",
"Eukaryota",
"metagenomes"
] | [
4097,
1,
5,
49
] | 4 | [] | [] | 0 | true | Family | Phosphate propanoyltransferase | Phosphate propanoyltransferase | PTAC | 1 |
IPR008302 | 8,302 | Peptidoglycan beta-N-acetylmuramidase NamZ | NamZ | Family | 7,974 | false | false | NamZ is an exo-beta-N-acetylmuramidase which catalyses an exo-lytic cleavage of beta-1,4-acetylmuramic acid from from the non-reducing ends of peptidoglycan chains [ ] and it is a founding member of a new family of glycosidases ( ). NamZ consists of a N-terminal catalytic domain with a Rossmann-like fold ( ) and a C-te... | [
"GO:0033922"
] | [
"peptidoglycan beta-N-acetylmuramidase activity"
] | [
"molecular_function"
] | 1 | [
"PIRSF",
"PANTHER"
] | [
"PIRSF016719",
"PTHR42915"
] | [
"UCP016719",
""
] | [
7205,
7974
] | 2 | [] | [] | [] | 0 | [
"4jja",
"4k05"
] | 2 | [
"PUB00100156"
] | [
"33684445"
] | [
"The exo-β-N-acetylmuramidase NamZ from Bacillus subtilis is the founding member of a family of exo-lytic peptidoglycan hexosaminidases."
] | [
2021
] | 1 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
21,
7625,
137,
191
] | 4 | [] | [] | 0 | true | Family | Peptidoglycan beta-N-acetylmuramidase NamZ | Peptidoglycan beta-N-acetylmuramidase NamZ | NamZ | 1 |
IPR008303 | 8,303 | Methanogenesis marker protein 14 | Methan_mark_14 | Family | 252 | false | false | Members of this protein family, to date, are found in a completed prokaryotic genome if and only if the species is one of the archaeal methanogens. The exact function is unknown, but likely is linked to methanogenesis or a process closely connected to it [ ]. | [] | [] | [] | 0 | [
"PFAM",
"PIRSF",
"NCBIFAM"
] | [
"PF09887",
"PIRSF016937",
"TIGR03285"
] | [
"DUF2114",
"UCP016937",
"methan_mark_14"
] | [
252,
229,
243
] | 3 | [
"GP"
] | [
"GenProp0722"
] | [
"GP:GenProp0722"
] | 1 | [] | 0 | [
"PUB00060475"
] | [
"22070167"
] | [
"ProPhylo: partial phylogenetic profiling to guide protein family construction and assignment of biological process."
] | [
2011
] | 1 | [] | [] | 0 | 0 | null | [
"Archaea",
"ecological metagenomes"
] | [
246,
6
] | 2 | [] | [] | 0 | true | Family | Methanogenesis marker protein 14 | Methanogenesis marker protein 14 | Methan_mark_14 | 3 |
IPR008304 | 8,304 | Uncharacterised conserved protein UCP017998 | UCP017998 | Family | 113 | false | false | This family consists of several hypothetical archaeal and bacterial proteins of unknown function, including from Aquifex aeolicus. The structure of this protein has been solved [ ] but its function remains unknown. Members of this family seem to have an acyl-CoA N-acyltransferase topology. | [] | [] | [] | 0 | [
"PFAM",
"PIRSF"
] | [
"PF06557",
"PIRSF017998"
] | [
"DUF1122",
"UCP017998"
] | [
113,
30
] | 2 | [] | [] | [] | 0 | [
"2arh",
"4zsv",
"4zsx",
"4zsz"
] | 4 | [
"PUB00100674"
] | [
"26243886"
] | [
"On the predictability of the orientation of protein domains joined by a spanning alpha-helical linker."
] | [
2015
] | 1 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"marine sediment metagenome"
] | [
94,
18,
1
] | 3 | [] | [] | 0 | true | Family | Uncharacterised conserved protein UCP017998 | Uncharacterised conserved protein UCP017998 | UCP017998 | 1 |
IPR008306 | 8,306 | Uncharacterised conserved protein UCP018008 | UCP018008 | Family | 699 | false | false | There are currently no experimental data for members of this group or their homologues, nor do they exhibit features indicative of any function. | [] | [] | [] | 0 | [
"PIRSF"
] | [
"PIRSF018008"
] | [
"UCP018008"
] | [
699
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00160784"
] | [
"38748582"
] | [
"YdbH and YnbE form an intermembrane bridge to maintain lipid homeostasis in the outer membrane of <i>Escherichia coli</i>."
] | [
2024
] | 1 | [
"IPR007362"
] | [] | 1 | 0 | 1 | [
"Archaea",
"Bacteria",
"freshwater metagenome"
] | [
2,
696,
1
] | 3 | [] | [] | 0 | true | Family | Uncharacterised conserved protein UCP018008 | Uncharacterised conserved protein UCP018008 | UCP018008 | 2 |
IPR008307 | 8,307 | Uncharacterised conserved protein UCP018957 | UCP018957 | Family | 845 | false | false | There are currently no experimental data for members of this group or their homologues, nor do they exhibit features indicative of any function. | [] | [] | [] | 0 | [
"PIRSF"
] | [
"PIRSF018957"
] | [
"UCP018957"
] | [
845
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00160784"
] | [
"38748582"
] | [
"YdbH and YnbE form an intermembrane bridge to maintain lipid homeostasis in the outer membrane of <i>Escherichia coli</i>."
] | [
2024
] | 1 | [
"IPR014923"
] | [] | 1 | 0 | 1 | [
"Bacteria",
"Geodia barretti",
"Nitrososphaeria",
"ecological metagenomes"
] | [
831,
2,
5,
7
] | 4 | [] | [] | 0 | true | Family | Uncharacterised conserved protein UCP018957 | Uncharacterised conserved protein UCP018957 | UCP018957 | 4 |
IPR008308 | 8,308 | YpbB protein | YpbB-like | Family | 1,172 | false | false | This entry represents the YpbB proteins from Bacillus subtilis and related proteins found mainly in Bacillales. YpbB assemble with RecS into a single complex able to interact with a protein of the replisome, the Single-Stranded DNA Binding protein (SSB), resulting in its targeting to active chromosome replication forks... | [] | [] | [] | 0 | [
"PIRSF"
] | [
"PIRSF021350"
] | [
"UCP021350"
] | [
1172
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00155446"
] | [
"21170359"
] | [
"The C-terminal domain of the bacterial SSB protein acts as a DNA maintenance hub at active chromosome replication forks."
] | [
2010
] | 1 | [] | [] | 0 | 0 | null | [
"Bacilli",
"human gut metagenome"
] | [
1171,
1
] | 2 | [] | [] | 0 | true | Family | YpbB protein | YpbB protein | YpbB-like | 3 |
IPR008309 | 8,309 | Probable chaperone-like protein YdbL | YdbL | Family | 3,402 | false | false | This entry represents YdbL (previously uncharacterised) and related bacterial proteins. This protein contains a small β-sheet connected to small α-helices. YdbL probably acts as a chaperone-like protein that contributes to, but is not essential for, the formation of the YdbH-YnbE intermembrane bridge. It affects both t... | [] | [] | [] | 0 | [
"PFAM",
"PIRSF"
] | [
"PF07027",
"PIRSF025560"
] | [
"DUF1318",
"UCP025560"
] | [
3402,
2163
] | 2 | [] | [] | [] | 0 | [] | 0 | [
"PUB00160784"
] | [
"38748582"
] | [
"YdbH and YnbE form an intermembrane bridge to maintain lipid homeostasis in the outer membrane of <i>Escherichia coli</i>."
] | [
2024
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"environmental samples",
"unclassified sequences"
] | [
3352,
5,
2,
43
] | 4 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Probable chaperone-like protein YdbL | Probable chaperone-like protein YdbL | YdbL | 4 |
IPR008310 | 8,310 | UPF0735 ACT domain-containing protein | UPF0735_ACT_dom-cont | Family | 2,610 | false | false | Members of this family contain a regulatory ACT domain with an additional N-terminal extension of ~70 aa, and therefore may be a stand-alone regulatory protein. | [] | [] | [] | 0 | [
"HAMAP",
"NCBIFAM",
"PIRSF"
] | [
"MF_00707",
"NF003361",
"PIRSF025624"
] | [
"UPF0735",
"PRK04435.1",
"ACT_PheB"
] | [
2329,
2609,
2537
] | 3 | [] | [] | [] | 0 | [] | 0 | [
"PUB00002073"
] | [
"2537815"
] | [
"The Bacillus subtilis spo0B stage 0 sporulation operon encodes an essential GTP-binding protein."
] | [
1989
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"metagenomes"
] | [
2595,
15
] | 2 | [] | [] | 0 | true | Family | UPF0735 ACT domain-containing protein | UPF0735 ACT domain-containing protein | UPF0735_ACT_dom-cont | 3 |
IPR008311 | 8,311 | Uncharacterised conserved protein UCP028101 | UCP028101 | Family | 3,004 | false | false | There are currently no experimental data for members of this group or their homologues, nor do they exhibit features indicative of any function. | [] | [] | [] | 0 | [
"PFAM",
"PIRSF"
] | [
"PF07433",
"PIRSF028101"
] | [
"DUF1513",
"UCP028101"
] | [
3004,
2680
] | 2 | [] | [] | [] | 0 | [] | 0 | [
"PUB00160784"
] | [
"38748582"
] | [
"YdbH and YnbE form an intermembrane bridge to maintain lipid homeostasis in the outer membrane of <i>Escherichia coli</i>."
] | [
2024
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
2978,
4,
22
] | 3 | [] | [] | 0 | true | Family | Uncharacterised conserved protein UCP028101 | Uncharacterised conserved protein UCP028101 | UCP028101 | 5 |
IPR008312 | 8,312 | Type VI secretion system sheath protein TssB1 | T6SS_TssB1 | Family | 7,756 | false | false | This entry includes TssB1, which is a sheath protein of the bacterial type VI secretion system (T6SS) [ ]. The type VI secretion system (T6SS), also known as CIS contractile injection system [ ], is a supra-molecular bacterial complex that resembles phage tails. It is a toxin delivery systems which fires toxins into ta... | [] | [] | [] | 0 | [
"PFAM",
"PIRSF",
"PANTHER",
"NCBIFAM"
] | [
"PF05591",
"PIRSF028301",
"PTHR35850",
"TIGR03358"
] | [
"T6SS_VipA",
"UCP028301",
"",
"VI_chp_5"
] | [
7755,
6899,
7286,
7262
] | 4 | [
"GP"
] | [
"GenProp0735"
] | [
"GP:GenProp0735"
] | 1 | [
"3j9g",
"3j9o",
"4ps2",
"4uqz",
"5mxn",
"5myu",
"5n8n",
"5ojq",
"5urw",
"5urx",
"9n4v"
] | 11 | [
"PUB00093972",
"PUB00093973",
"PUB00093981",
"PUB00160456"
] | [
"27288401",
"31379775",
"29307484",
"39546591"
] | [
"TssA forms a gp6-like ring attached to the type VI secretion sheath.",
"Baseplate Component TssK and Spatio-Temporal Assembly of T6SS in Pseudomonas aeruginosa.",
"Atomic Structure of Type VI Contractile Sheath from Pseudomonas aeruginosa.",
"Archaeal type six secretion system mediates contact-dependent anta... | [
2016,
2019,
2018,
2024
] | 4 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
7688,
14,
54
] | 3 | [] | [] | 0 | true | Family | Type VI secretion system sheath protein TssB1 | Type VI secretion system sheath protein TssB1 | T6SS_TssB1 | 3 |
IPR008313 | 8,313 | Metal-independent alpha-mannosidase | GH125 | Family | 7,417 | false | false | This family includes proteins from bacteria and fungi. It was originally identified as a protein of unknown function from Schizosaccharomyces pombe, which was isolated from a screen to identify novel genes required for meiosis [ ]. Members of this family have since been characterised from Streptococcus pneumoniae ( ) a... | [] | [] | [] | 0 | [
"PFAM",
"PIRSF",
"PANTHER",
"SMART"
] | [
"PF06824",
"PIRSF028846",
"PTHR31047",
"SM01149"
] | [
"Glyco_hydro_125",
"UCP028846",
"",
"DUF1237"
] | [
7400,
6174,
7288,
7235
] | 4 | [] | [] | [] | 0 | [
"2nvp",
"2p0v",
"3on6",
"3p2c",
"3qpf",
"3qry",
"3qsp",
"3qt3",
"3qt9",
"5m7i",
"5m7y",
"6rqk"
] | 12 | [
"PUB00044889",
"PUB00055745"
] | [
"16303567",
"21388958"
] | [
"A large-scale screen in S. pombe identifies seven novel genes required for critical meiotic events.",
"Analysis of a new family of widely distributed metal-independent alpha-mannosidases provides unique insight into the processing of N-linked glycans."
] | [
2005,
2011
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Candidatus Methanophaga sp. ANME-1 ERB7",
"Eukaryota",
"metagenomes"
] | [
4048,
1,
3313,
55
] | 4 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
3,
1
] | 2 | true | Family | Metal-independent alpha-mannosidase | Metal-independent alpha-mannosidase | GH125 | 9 |
IPR008314 | 8,314 | N(4)-acetylcytidine amidohydrolase | AC4CH | Family | 1,665 | false | false | N(4)-acetylcytidine amidohydrolase catalyses the hydrolysis of N4-acetylcytidine (ac4C). It contains the human activating signal cointegrator homology (ASCH) domain with unknown function, although this domain has been suggested to be responsible for RNA binding during transcription activation, RNA processing and regula... | [] | [] | [] | 0 | [
"HAMAP",
"NCBIFAM",
"PIRSF",
"PANTHER"
] | [
"MF_00684",
"NF003443",
"PIRSF029143",
"PTHR38088"
] | [
"ac4C_amidohydr",
"PRK04980.1",
"UCP029143",
""
] | [
1584,
1642,
1507,
1660
] | 4 | [
"EC"
] | [
"3.5.1.135"
] | [
"EC:3.5.1.135"
] | 1 | [
"1te7",
"9kyf",
"9kyg",
"9kyh"
] | 4 | [
"PUB00037702",
"PUB00044668",
"PUB00094246"
] | [
"15969587",
"16322048",
"31964920"
] | [
"G-matrix Fourier transform NOESY-based protocol for high-quality protein structure determination.",
"The ASCH superfamily: novel domains with a fold related to the PUA domain and a potential role in RNA metabolism.",
"YqfB protein from Escherichia coli: an atypical amidohydrolase active towards N4-acylcytosine... | [
2005,
2006,
2020
] | 3 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota"
] | [
1659,
6
] | 2 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | N(4)-acetylcytidine amidohydrolase | N(4)-acetylcytidine amidohydrolase | AC4CH | 3 |
IPR008316 | 8,316 | Uncharacterised conserved protein UCP029876 | UCP029876 | Family | 2,973 | false | false | There are currently no experimental data for members of this group or their homologues, nor do they exhibit features indicative of any function. | [] | [] | [] | 0 | [
"PFAM",
"PIRSF"
] | [
"PF06304",
"PIRSF029876"
] | [
"DUF1048",
"UCP029876"
] | [
2973,
728
] | 2 | [] | [] | [] | 0 | [
"2hh6",
"2o3l",
"2o4t"
] | 3 | [
"PUB00160784"
] | [
"38748582"
] | [
"YdbH and YnbE form an intermembrane bridge to maintain lipid homeostasis in the outer membrane of <i>Escherichia coli</i>."
] | [
2024
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"bioreactor metagenome"
] | [
2958,
15
] | 2 | [] | [] | 0 | true | Family | Uncharacterised conserved protein UCP029876 | Uncharacterised conserved protein UCP029876 | UCP029876 | 3 |
IPR008317 | 8,317 | Uncharacterised conserved protein UCP030561 | UCP030561 | Family | 776 | false | false | There are currently no experimental data for members of this group or their homologues, nor do they exhibit features indicative of any function. Though the N-terminal half of these proteins is related to the N-terminal half of steroid delta-isomerase, the C-terminal half is predicted to be structurally unrelated. Both ... | [] | [] | [] | 0 | [
"PIRSF"
] | [
"PIRSF030561"
] | [
"UCP030561"
] | [
776
] | 1 | [] | [] | [] | 0 | [
"2k54"
] | 1 | [
"PUB00011187"
] | [
"11751047"
] | [
"Structure and enzymology of Delta5-3-ketosteroid isomerase."
] | [
2001
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Halobacterium",
"bioreactor metagenome"
] | [
763,
6,
6,
1
] | 4 | [] | [] | 0 | true | Family | Uncharacterised conserved protein UCP030561 | Uncharacterised conserved protein UCP030561 | UCP030561 | 1 |
IPR008318 | 8,318 | Uncharacterised conserved protein UCP030820 | UCP030820 | Family | 5,968 | false | false | There are currently no experimental data for members of this group or their homologues, nor do they exhibit features indicative of any function. | [] | [] | [] | 0 | [
"PFAM",
"PIRSF"
] | [
"PF06073",
"PIRSF030820"
] | [
"DUF934",
"UCP030820"
] | [
5968,
4312
] | 2 | [] | [] | [] | 0 | [] | 0 | [
"PUB00160784"
] | [
"38748582"
] | [
"YdbH and YnbE form an intermembrane bridge to maintain lipid homeostasis in the outer membrane of <i>Escherichia coli</i>."
] | [
2024
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
5900,
6,
62
] | 3 | [] | [] | 0 | true | Family | Uncharacterised conserved protein UCP030820 | Uncharacterised conserved protein UCP030820 | UCP030820 | 6 |
IPR008319 | 8,319 | GyrI-like cyclopropanoid cyclopropyl hydrolase Lin2189-like | GyrI-like_CCH_Lin2189-like | Family | 2,823 | false | false | This family of prokaryotic GyrI-like proteins include Lin2189 protein from Listeria innocua ( ), a cyclopropanoid cyclopropyl hydrolase (CCHs) that can catalyse the hydrolysis of the potent DNA-alkylating agents yatakemycin (YTM) and CC-1065, protecting the cells. This protein shows three α-helices and six β-strands an... | [] | [] | [] | 0 | [
"PIRSF"
] | [
"PIRSF031644"
] | [
"UCP031644"
] | [
2823
] | 1 | [] | [] | [] | 0 | [
"3b49",
"5x5m",
"5x5r"
] | 3 | [
"PUB00101004"
] | [
"29133784"
] | [
"GyrI-like proteins catalyze cyclopropanoid hydrolysis to confer cellular protection."
] | [
2017
] | 1 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Didymella rabiei",
"Siphoviridae sp. ctP6p7",
"ecological metagenomes"
] | [
31,
2751,
1,
1,
39
] | 5 | [] | [] | 0 | true | Family | GyrI-like cyclopropanoid cyclopropyl hydrolase Lin2189-like | GyrI-like cyclopropanoid cyclopropyl hydrolase Lin2189-like | GyrI-like_CCH_Lin2189-like | 4 |
IPR008320 | 8,320 | Uncharacterised conserved protein UCP032025 | UCP032025 | Family | 2,731 | false | false | This family consists of several hypothetical bacterial proteins of around 150 residues in length. Members of this family seem to be founds exclusively in the Class Alphaproteobacteria. The function of this family is unknown. | [] | [] | [] | 0 | [
"PFAM",
"PIRSF"
] | [
"PF07370",
"PIRSF032025"
] | [
"DUF1489",
"UCP032025"
] | [
2731,
2685
] | 2 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Pseudomonadati",
"unclassified sequences"
] | [
2711,
20
] | 2 | [] | [] | 0 | true | Family | Uncharacterised conserved protein UCP032025 | Uncharacterised conserved protein UCP032025 | UCP032025 | 8 |
IPR008321 | 8,321 | Uncharacterised conserved protein UCP032146 | UCP032146 | Family | 2,636 | false | false | This protein family is functionally uncharacterised. | [] | [] | [] | 0 | [
"HAMAP",
"NCBIFAM",
"PFAM",
"PIRSF"
] | [
"MF_00678",
"NF002769",
"PF06793",
"PIRSF032146"
] | [
"UPF0262",
"PRK02853.1",
"UPF0262",
"UCP032146"
] | [
2282,
2584,
2636,
2228
] | 4 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Pseudomonadati",
"metagenomes"
] | [
3,
2605,
28
] | 3 | [] | [] | 0 | true | Family | Uncharacterised conserved protein UCP032146 | Uncharacterised conserved protein UCP032146 | UCP032146 | 3 |
IPR008322 | 8,322 | Uncharacterised protein family UPF0261 | UPF0261 | Family | 3,456 | false | false | The proteins in this entry are functionally uncharacterised. | [] | [] | [] | 0 | [
"HAMAP",
"PIRSF"
] | [
"MF_00677",
"PIRSF033271"
] | [
"UPF0261",
"UCP033271"
] | [
676,
3348
] | 2 | [] | [] | [] | 0 | [
"3wrw",
"3wrx",
"3wry",
"9mpy"
] | 4 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
89,
2635,
709,
23
] | 4 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Zea mays"
] | [
1,
1
] | 2 | true | Family | Uncharacterised protein family UPF0261 | Uncharacterised protein family UPF0261 | UPF0261 | 8 |
IPR008323 | 8,323 | Uncharacterised conserved protein UCP033563 | UCP033563 | Family | 7,654 | false | false | There are currently no experimental data for members of this group or their homologues, nor do they exhibit features indicative of any function. | [] | [] | [] | 0 | [
"PFAM",
"PIRSF",
"PANTHER"
] | [
"PF06245",
"PIRSF033563",
"PTHR36454"
] | [
"DUF1015",
"UCP033563",
""
] | [
7584,
5216,
7555
] | 3 | [] | [] | [] | 0 | [] | 0 | [
"PUB00160784"
] | [
"38748582"
] | [
"YdbH and YnbE form an intermembrane bridge to maintain lipid homeostasis in the outer membrane of <i>Escherichia coli</i>."
] | [
2024
] | 1 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
122,
7041,
89,
402
] | 4 | [] | [] | 0 | true | Family | Uncharacterised conserved protein UCP033563 | Uncharacterised conserved protein UCP033563 | UCP033563 | 1 |
IPR008325 | 8,325 | EipA-like | EipA-like | Family | 1,814 | false | false | The member of this family for Brucella abortus, named EipA, has been characterised as a molecular determinant of virulence that functions to maintain cell envelope integrity [ ]. | [] | [] | [] | 0 | [
"PFAM",
"PIRSF"
] | [
"PF06577",
"PIRSF033924"
] | [
"EipA",
"UCP033924"
] | [
1814,
1120
] | 2 | [] | [] | [] | 0 | [
"5uc0"
] | 1 | [
"PUB00091721"
] | [
"30536925"
] | [
"Periplasmic protein EipA determines envelope stress resistance and virulence in Brucella abortus."
] | [
2018
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"ecological metagenomes"
] | [
1797,
2,
15
] | 3 | [] | [] | 0 | true | Family | EipA-like | EipA-like | EipA-like | 8 |
IPR008326 | 8,326 | Pyruvate dehydrogenase inhibitor-like | PdhI-like | Family | 1,659 | false | false | This entry represents Pyruvate dehydrogenase inhibitor from Bacillus subtilis (PdhI) and similar sequences from firmicutes. PdhI functions as an inhibitor of the pyruvate dehydrogenase [ ]. | [] | [] | [] | 0 | [
"PIRSF"
] | [
"PIRSF034852"
] | [
"UCP034852"
] | [
1659
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00154956"
] | [
"36815589"
] | [
"Protein complexes in cells by AI-assisted structural proteomics."
] | [
2023
] | 1 | [] | [] | 0 | 0 | null | [
"Bacillota"
] | [
1659
] | 1 | [] | [] | 0 | true | Family | Pyruvate dehydrogenase inhibitor-like | Pyruvate dehydrogenase inhibitor-like | PdhI-like | 7 |
IPR008327 | 8,327 | Signal transduction response regulator, antiterminator | Sig_transdc_resp-reg_antiterm | Family | 11,238 | false | false | Two-component signal transduction systems enable bacteria to sense, respond, and adapt to a wide range of environments, stressors, and growth conditions [ ]. Some bacteria can contain up to as many as 200 two-component systems that need tight regulation to prevent unwanted cross-talk [ ]. These pathways have been adapt... | [] | [] | [] | 0 | [
"PIRSF"
] | [
"PIRSF036382"
] | [
"RR_antiterm"
] | [
11238
] | 1 | [] | [] | [] | 0 | [
"1qo0",
"1s8n",
"1sd5",
"6wsh",
"6ww6"
] | 5 | [
"PUB00001238",
"PUB00007866",
"PUB00010651",
"PUB00011096",
"PUB00011157",
"PUB00011190",
"PUB00011191",
"PUB00011192",
"PUB00011193",
"PUB00011194",
"PUB00042804",
"PUB00042805",
"PUB00042806",
"PUB00042807"
] | [
"8253087",
"11406410",
"12372152",
"10966457",
"10622255",
"10500846",
"10508151",
"10893220",
"11796212",
"8918468",
"16176121",
"18076326",
"11934609",
"11489844"
] | [
"Antitermination of amidase expression in Pseudomonas aeruginosa is controlled by a novel cytoplasmic amide-binding protein.",
"Histidine kinases and response regulator proteins in two-component signaling systems.",
"Histidine protein kinases: key signal transducers outside the animal kingdom.",
"Two-componen... | [
1993,
2001,
2002,
2000,
1999,
1999,
1999,
2000,
2002,
1996,
2005,
2007,
2002,
2001
] | 14 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Methanobacteriota",
"unclassified sequences"
] | [
10976,
5,
13,
244
] | 4 | [] | [] | 0 | true | Family | Signal transduction response regulator, antiterminator | Signal transduction response regulator, antiterminator | Sig_transdc_resp-reg_antiterm | 8 |
IPR008330 | 8,330 | Peptidase M17, peptidase B | Pept_M17_PepB | Family | 2,665 | false | false | This family represents the peptidase B group of leucyl aminopeptidases, which are restricted to the gammaproteobacteria. They contain a C-terminal aminopeptidase catalytic domain and an N-terminal domain of unknown function. They are zinc-dependent exopeptidases ( ) and belong to MEROPS peptidase family M17 (leucyl ami... | [
"GO:0030145",
"GO:0070006",
"GO:0006508",
"GO:0005737"
] | [
"manganese ion binding",
"metalloaminopeptidase activity",
"proteolysis",
"cytoplasm"
] | [
"molecular_function",
"molecular_function",
"biological_process",
"cellular_component"
] | 4 | [
"HAMAP",
"NCBIFAM",
"PIRSF"
] | [
"MF_00504",
"NF003450",
"PIRSF036388"
] | [
"Aminopeptidase_M17",
"PRK05015.1",
"Ctsl_amnpptdse_B"
] | [
1269,
2663,
2550
] | 3 | [
"EC"
] | [
"3.4.11.23"
] | [
"EC:3.4.11.23"
] | 1 | [
"6cxd",
"6oad",
"6ov8"
] | 3 | [
"PUB00000522",
"PUB00001416",
"PUB00003579",
"PUB00004713",
"PUB00011211",
"PUB00011212",
"PUB00011213",
"PUB00011214",
"PUB00011215"
] | [
"8439290",
"1555602",
"7674922",
"2395881",
"8703509",
"10449417",
"10970742",
"10852868",
"8506345"
] | [
"Evolutionary families of peptidases.",
"Leucine aminopeptidase from Arabidopsis thaliana. Molecular evidence for a phylogenetically conserved enzyme of protein turnover in higher plants.",
"Evolutionary families of metallopeptidases.",
"Molecular structure of leucine aminopeptidase at 2.7-A resolution.",
"... | [
1993,
1992,
1995,
1990,
1996,
1999,
2000,
2000,
1993
] | 9 | [
"IPR011356"
] | [] | 1 | 0 | 1 | [
"Bacteria",
"Opisthokonta",
"unclassified sequences"
] | [
2661,
2,
2
] | 3 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Peptidase M17, peptidase B | Peptidase M17, peptidase B | Pept_M17_PepB | 1 |
IPR008332 | 8,332 | Methylguanine DNA methyltransferase, ribonuclease-like domain | MethylG_MeTrfase_N | Domain | 26,694 | false | false | The repair of DNA containing O6-alkylated guanine is carried out by DNA-[protein]-cysteine S-methyltransferase ( ) (also known as 6-O-methylguanine-DNA methyltransferase, O-6-methylguanine-DNA-alkyltransferase). The major mutagenic and carcinogenic effect of methylating agents in DNA is the formation of O6-alkylguanine... | [
"GO:0003908",
"GO:0006281"
] | [
"methylated-DNA-[protein]-cysteine S-methyltransferase activity",
"DNA repair"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PFAM"
] | [
"PF02870"
] | [
"Methyltransf_1N"
] | [
26694
] | 1 | [
"EC",
"REACTOME"
] | [
"2.1.1.63",
"R-HSA-5657655"
] | [
"EC:2.1.1.63",
"REACTOME:R-HSA-5657655"
] | 2 | [
"1eh6",
"1eh7",
"1eh8",
"1qnt",
"1sfe",
"1t38",
"1t39",
"1wrj",
"1yfh",
"3kzy",
"3kzz",
"3l00",
"4bhb",
"4bhc",
"4wx9",
"4wxc",
"4wxd",
"4zyd",
"4zye",
"4zyg",
"4zyh",
"5llq",
"6ga0",
"6rla",
"6rlb",
"6sc2",
"6y8p",
"7csm",
"7d4v",
"7dkn",
"7dqq",
"7dqr"... | 65 | [
"PUB00000053",
"PUB00004404"
] | [
"3052269",
"1579490"
] | [
"Regulation and expression of the adaptive response to alkylating agents.",
"Isolation and partial characterisation of a Chinese hamster O6-alkylguanine-DNA alkyltransferase cDNA."
] | [
1988,
1992
] | 2 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
132,
25525,
808,
229
] | 4 | [
"Danio rerio",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
7,
2,
5,
2,
3
] | 5 | true | Domain | Methylguanine DNA methyltransferase, ribonuclease-like domain | Methylguanine DNA methyltransferase, ribonuclease-like domain | MethylG_MeTrfase_N | 2 |
IPR008333 | 8,333 | Flavoprotein pyridine nucleotide cytochrome reductase-like, FAD-binding domain | Cbr1-like_FAD-bd_dom | Domain | 90,148 | false | false | These sequences represent the FAD-binding domain found in NADH:cytochrome b5 reductases and nitrate reductases. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF00970"
] | [
"FAD_binding_6"
] | [
90148
] | 1 | [
"GP",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
... | [
"GenProp1554",
"R-BTA-114608",
"R-BTA-1237044",
"R-BTA-196836",
"R-BTA-211945",
"R-BTA-6798695",
"R-CFA-196836",
"R-CFA-211945",
"R-CFA-6798695",
"R-DDI-114608",
"R-DDI-196836",
"R-DDI-211945",
"R-DDI-6798695",
"R-DRE-1237044",
"R-HSA-114608",
"R-HSA-1237044",
"R-HSA-196836",
"R-HS... | [
"GP:GenProp1554",
"REACTOME:R-BTA-114608",
"REACTOME:R-BTA-1237044",
"REACTOME:R-BTA-196836",
"REACTOME:R-BTA-211945",
"REACTOME:R-BTA-6798695",
"REACTOME:R-CFA-196836",
"REACTOME:R-CFA-211945",
"REACTOME:R-CFA-6798695",
"REACTOME:R-DDI-114608",
"REACTOME:R-DDI-196836",
"REACTOME:R-DDI-211945"... | 36 | [
"1a8p",
"1cne",
"1cnf",
"1fdr",
"1gaq",
"1gaw",
"1gvh",
"1i7p",
"1ib0",
"1krh",
"1ndh",
"1qfj",
"1qx4",
"1tvc",
"1umk",
"2bgi",
"2bgj",
"2cnd",
"2eix",
"2qdx",
"2r6h",
"2vnh",
"2vni",
"2vnj",
"2vnk",
"2xnc",
"2xnj",
"3crz",
"3fpk",
"3w2e",
"3w2f",
"3w2g"... | 108 | [
"PUB00000415",
"PUB00002370",
"PUB00005247"
] | [
"7893687",
"8027025",
"7812715"
] | [
"Crystal structure of NADH-cytochrome b5 reductase from pig liver at 2.4 A resolution.",
"Structure-function relations for ferredoxin reductase.",
"Crystal structure of the FAD-containing fragment of corn nitrate reductase at 2.5 A resolution: relationship to other flavoprotein reductases."
] | [
1995,
1994,
1994
] | 3 | [
"IPR017927"
] | [] | 1 | 0 | 1 | [
"Archaea",
"Bacteria",
"Eukaryota",
"Vibrio phage VP-HS15",
"plasmids",
"unclassified sequences"
] | [
738,
66718,
22118,
1,
2,
571
] | 6 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
17,
5,
13,
11,
5,
28,
12,
8,
18,
32,
6,
3,
37
] | 13 | true | Domain | Flavoprotein pyridine nucleotide cytochrome reductase-like, FAD-binding domain | Flavoprotein pyridine nucleotide cytochrome reductase-like, FAD-binding domain | Cbr1-like_FAD-bd_dom | 5 |
IPR008334 | 8,334 | 5'-Nucleotidase, C-terminal | 5'-Nucleotdase_C | Domain | 45,338 | false | false | This entry is the C-terminal domain of 5'-nucleotidases. 5'-nucleotidases [ ] are enzymes that catalyse the hydrolysis of phosphate esterified at carbon 5' of the ribose and deoxyribose portions of nucleotide molecules. 5'-nucleotidase is a ubiquitous enzyme found in a wide variety of species and which occurs in differ... | [
"GO:0016787",
"GO:0009166"
] | [
"hydrolase activity",
"nucleotide catabolic process"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PFAM"
] | [
"PF02872"
] | [
"5_nucleotid_C"
] | [
45338
] | 1 | [
"EC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"3.1.3",
"R-HSA-196807",
"R-HSA-73621",
"R-HSA-74259",
"R-HSA-9660826",
"R-MMU-196807",
"R-MMU-73621",
"R-MMU-74259",
"R-RNO-196807",
"R-RNO-73621",
"R-RNO-74259"
] | [
"EC:3.1.3",
"REACTOME:R-HSA-196807",
"REACTOME:R-HSA-73621",
"REACTOME:R-HSA-74259",
"REACTOME:R-HSA-9660826",
"REACTOME:R-MMU-196807",
"REACTOME:R-MMU-73621",
"REACTOME:R-MMU-74259",
"REACTOME:R-RNO-196807",
"REACTOME:R-RNO-73621",
"REACTOME:R-RNO-74259"
] | 11 | [
"1ho5",
"1hp1",
"1hpu",
"1oi8",
"1oid",
"1oie",
"1ush",
"2ush",
"2wdc",
"2wdd",
"2wde",
"2wdf",
"2z1a",
"3ivd",
"3ive",
"3qfk",
"3ztv",
"3zu0",
"4h1s",
"4h1y",
"4h2b",
"4h2f",
"4h2g",
"4h2i",
"4q7f",
"4uwq",
"4wwl",
"5h7w",
"6hxw",
"6s7f",
"6s7h",
"6tve"... | 71 | [
"PUB00000512",
"PUB00004869",
"PUB00008988",
"PUB00008989"
] | [
"1637327",
"7846038",
"9015312",
"2550543"
] | [
"5'-Nucleotidase: molecular structure and functional aspects.",
"The salivary gland-specific apyrase of the mosquito Aedes aegypti is a member of the 5'-nucleotidase family.",
"Differential regulation and function of CD73, a glycosyl-phosphatidylinositol-linked 70-kD adhesion molecule, on lymphocytes and endoth... | [
1992,
1995,
1997,
1989
] | 4 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
560,
36726,
7744,
24,
284
] | 5 | [
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus"
] | [
2,
20,
2,
7,
5,
2,
6
] | 7 | true | Domain | 5'-Nucleotidase, C-terminal | 5'-Nucleotidase, C-terminal | 5'-Nucleotdase_C | 4 |
IPR008335 | 8,335 | Eukaryotic molybdopterin oxidoreductase | Mopterin_OxRdtase_euk | Family | 19,214 | false | false | A number of different eukaryotic oxidoreductases that require and bind a molybdopterin cofactor have been shown [ ] to share a few regions of sequence similarity. These enzymes include xanthine dehydrogenase ( ), aldehyde oxidase ( ), nitrate reductase ( ), and sulphite oxidase ( ). The multidomain redox enzyme NAD(P)H... | [
"GO:0016491"
] | [
"oxidoreductase activity"
] | [
"molecular_function"
] | 1 | [
"PRINTS"
] | [
"PR00407"
] | [
"EUMOPTERIN"
] | [
19214
] | 1 | [
"EC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"1.7.1",
"R-DME-1614517",
"R-HSA-1614517",
"R-MMU-1614517",
"R-RNO-1614517"
] | [
"EC:1.7.1",
"REACTOME:R-DME-1614517",
"REACTOME:R-HSA-1614517",
"REACTOME:R-MMU-1614517",
"REACTOME:R-RNO-1614517"
] | 5 | [
"1ogp",
"1sox",
"2a99",
"2a9a",
"2a9b",
"2a9c",
"2a9d",
"2bih",
"2bii",
"2blf",
"2bpb",
"2c9x",
"2ca3",
"2ca4",
"2xts",
"3hbg",
"3hbp",
"3hbq",
"3hc2",
"3r18",
"3r19",
"4pw3",
"4pw9",
"5k3x",
"5wa0",
"6y0k",
"8s5s"
] | 27 | [
"PUB00000608",
"PUB00002526",
"PUB00002593",
"PUB00002947",
"PUB00005356"
] | [
"2015248",
"2687265",
"2249998",
"7896804",
"2204158"
] | [
"Enzymes depending on the pterin molybdenum cofactor: sequence families, spectroscopic properties of molybdenum and possible cofactor-binding domains.",
"Conserved domains in molybdenum hydroxylases. The amino acid sequence of chicken hepatic sulfite oxidase.",
"A conserved cysteine in molybdenum oxotransferase... | [
1991,
1989,
1990,
1995,
1990
] | 5 | [] | [
"IPR030835"
] | 0 | 1 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"Harvfovirus sp.",
"unclassified sequences"
] | [
151,
8650,
10267,
1,
145
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
18,
2,
4,
1,
3,
1,
3,
15,
3,
39
] | 10 | true | Family | Eukaryotic molybdopterin oxidoreductase | Eukaryotic molybdopterin oxidoreductase | Mopterin_OxRdtase_euk | 6 |
IPR008336 | 8,336 | DNA topoisomerase I, DNA binding, eukaryotic-type | TopoI_DNA-bd_euk | Domain | 9,484 | false | false | DNA topoisomerases regulate the number of topological links between two DNA strands (i.e. change the number of superhelical turns) by catalysing transient single-or double-strand breaks, crossing the strands through one another, then resealing the breaks [ ]. These enzymes have several functions: to remove DNA supercoi... | [
"GO:0003677",
"GO:0003917",
"GO:0006265"
] | [
"DNA binding",
"DNA topoisomerase type I (single strand cut, ATP-independent) activity",
"DNA topological change"
] | [
"molecular_function",
"molecular_function",
"biological_process"
] | 3 | [
"PFAM"
] | [
"PF02919"
] | [
"Topoisom_I_N"
] | [
9484
] | 1 | [
"EC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"5.6.2.1",
"R-CEL-4615885",
"R-DDI-4615885",
"R-HSA-4615885",
"R-MMU-4615885",
"R-RNO-4615885",
"R-SCE-4615885",
"R-SPO-4615885"
] | [
"EC:5.6.2.1",
"REACTOME:R-CEL-4615885",
"REACTOME:R-DDI-4615885",
"REACTOME:R-HSA-4615885",
"REACTOME:R-MMU-4615885",
"REACTOME:R-RNO-4615885",
"REACTOME:R-SCE-4615885",
"REACTOME:R-SPO-4615885"
] | 8 | [
"1a31",
"1a35",
"1a36",
"1ej9",
"1k4s",
"1k4t",
"1lpq",
"1nh3",
"1ois",
"1r49",
"1rr8",
"1rrj",
"1sc7",
"1seu",
"1t8i",
"1tl8",
"2b9s",
"6z01",
"6z03"
] | 19 | [
"PUB00005230",
"PUB00005437",
"PUB00016842",
"PUB00020793",
"PUB00020794",
"PUB00020800",
"PUB00081702",
"PUB00081703",
"PUB00081704",
"PUB00081705"
] | [
"9488644",
"7770916",
"11395412",
"12596227",
"12042765",
"14741206",
"21087076",
"20644584",
"17722649",
"17293019"
] | [
"Crystal structures of human topoisomerase I in covalent and noncovalent complexes with DNA.",
"The mechanisms of DNA topoisomerases.",
"DNA topoisomerases: structure, function, and mechanism.",
"Phylogenomics of type II DNA topoisomerases.",
"Cellular roles of DNA topoisomerases: a molecular perspective.",... | [
1998,
1995,
2001,
2003,
2002,
2004,
2010,
2010,
2007,
2007
] | 10 | [] | [
"IPR048045"
] | 0 | 1 | 0 | [
"Archaea",
"Eukaryota",
"Megaviricetes",
"metagenomes"
] | [
99,
9324,
35,
26
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
12,
1,
7,
7,
19,
5,
2,
2,
10,
1,
1,
19
] | 12 | true | Domain | DNA topoisomerase I, DNA binding, eukaryotic-type | DNA topoisomerase I, DNA binding, eukaryotic-type | TopoI_DNA-bd_euk | 4 |
IPR008337 | 8,337 | Capsule biosynthesis protein CapB | Capsule_biosynth_CapB | Family | 1,315 | false | false | Bacillus spp. are Gram-positive aerobic rods that are able to form endo- spores that allow them to survive in almost any environment. The many different species exhibit a wide variation of physiological abilities, their spores being resistant, for example, to heat, cold, disinfection and radiation. However, the spores ... | [
"GO:0045227",
"GO:0016020"
] | [
"capsule polysaccharide biosynthetic process",
"membrane"
] | [
"biological_process",
"cellular_component"
] | 2 | [
"PRINTS",
"NCBIFAM"
] | [
"PR01758",
"TIGR04012"
] | [
"CAPSULEPROTB",
"poly_gGlu_PgsB"
] | [
1312,
1114
] | 2 | [
"GP"
] | [
"GenProp0822"
] | [
"GP:GenProp0822"
] | 1 | [] | 0 | [
"PUB00011559",
"PUB00011560"
] | [
"2536679",
"8945528"
] | [
"Molecular characterization and protein analysis of the cap region, which is essential for encapsulation in Bacillus anthracis.",
"Differential influence of the two Bacillus anthracis plasmids on regulation of virulence gene expression."
] | [
1989,
1996
] | 2 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"metagenomes"
] | [
17,
1262,
36
] | 3 | [] | [] | 0 | true | Family | Capsule biosynthesis protein CapB | Capsule biosynthesis protein CapB | Capsule_biosynth_CapB | 6 |
IPR008338 | 8,338 | Capsule biosynthesis protein CapC | Capsule_biosynth_CapC | Family | 1,409 | false | false | Bacillus spp. are Gram-positive aerobic rods that are able to form endo-spores that allow them to survive in almost any environment. The many different species exhibit a wide variation of physiological abilities, their spores being resistant, for example, to heat, cold, disinfection and radiation. However, the spores r... | [
"GO:0045227",
"GO:0016020"
] | [
"capsule polysaccharide biosynthetic process",
"membrane"
] | [
"biological_process",
"cellular_component"
] | 2 | [
"PFAM",
"PRINTS",
"NCBIFAM"
] | [
"PF14102",
"PR01759",
"TIGR04011"
] | [
"Caps_synth_CapC",
"CAPSULEPROTC",
"poly_gGlu_PgsC"
] | [
1409,
893,
661
] | 3 | [
"GP"
] | [
"GenProp0822"
] | [
"GP:GenProp0822"
] | 1 | [] | 0 | [
"PUB00011559",
"PUB00011560"
] | [
"2536679",
"8945528"
] | [
"Molecular characterization and protein analysis of the cap region, which is essential for encapsulation in Bacillus anthracis.",
"Differential influence of the two Bacillus anthracis plasmids on regulation of virulence gene expression."
] | [
1989,
1996
] | 2 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Cladocopium goreaui",
"metagenomes"
] | [
97,
1273,
1,
38
] | 4 | [] | [] | 0 | true | Family | Capsule biosynthesis protein CapC | Capsule biosynthesis protein CapC | Capsule_biosynth_CapC | 5 |
IPR008339 | 8,339 | Dishevelled family | Dishevelled_fam | Family | 4,849 | false | false | Wnt proteins constitute a large family of secreted signalling molecules that are involved in intercellular signalling during development. The name derives from the first 2 members of the family to be discovered: int-1 (mouse) and wingless (Wg) (Drosophila) [ ]. It is now recognised that Wnt signalling controls many cel... | [
"GO:0016055"
] | [
"Wnt signaling pathway"
] | [
"biological_process"
] | 1 | [
"PRINTS"
] | [
"PR01760"
] | [
"DISHEVELLED"
] | [
4849
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-DME-201688",
"R-DME-209440",
"R-DME-350368",
"R-DME-350369",
"R-DME-350376",
"R-DME-350411",
"R-DME-350480",
"R-DME-4086400",
"R-DME-450728",
"R-DME-4608870",
"R-DME-4641258",
"R-DME-4641262",
"R-DME-5099900",
"R-DME-5663220",
"R-HSA-201681",
"R-HSA-201688",
"R-HSA-2028269",
"R-... | [
"REACTOME:R-DME-201688",
"REACTOME:R-DME-209440",
"REACTOME:R-DME-350368",
"REACTOME:R-DME-350369",
"REACTOME:R-DME-350376",
"REACTOME:R-DME-350411",
"REACTOME:R-DME-350480",
"REACTOME:R-DME-4086400",
"REACTOME:R-DME-450728",
"REACTOME:R-DME-4608870",
"REACTOME:R-DME-4641258",
"REACTOME:R-DME-... | 49 | [
"1fsh",
"5lnp",
"5suy",
"5suz",
"8wm9",
"8wma"
] | 6 | [
"PUB00011232",
"PUB00011233",
"PUB00011234",
"PUB00011235",
"PUB00060615"
] | [
"9891778",
"10967351",
"10733430",
"12072470",
"9867820"
] | [
"Mechanisms of Wnt signaling in development.",
"Wnt signaling function in Alzheimer's disease.",
"Wnt signaling in oncogenesis and embryogenesis--a look outside the nucleus.",
"A mutational analysis of dishevelled in Drosophila defines novel domains in the dishevelled protein as well as novel suppressing alle... | [
1998,
2000,
2000,
2002,
1999
] | 5 | [
"IPR015506"
] | [
"IPR008341",
"IPR008342"
] | 1 | 2 | 0 | [
"Metazoa"
] | [
4849
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
6,
26,
1,
19,
8,
9
] | 6 | true | Family | Dishevelled family | Dishevelled family | Dishevelled_fam | 5 |
IPR008341 | 8,341 | Dishevelled-2 | DVL2 | Family | 342 | false | false | Dishevelled (Dsh) proteins possess three conserved domains: an amino-terminal DIX domain, a central PDZ and a carboxyl-terminal DEP domain. They acts downstream of Fz receptors in the Wnt signalling pathway, which controls a variety of developmental and homeostatic events [ ]. Dishevelled-2 (DVL-2) participates in Wnt ... | [
"GO:0016055"
] | [
"Wnt signaling pathway"
] | [
"biological_process"
] | 1 | [
"PRINTS"
] | [
"PR01762"
] | [
"DISHEVELLED2"
] | [
342
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-HSA-201681",
"R-HSA-201688",
"R-HSA-2028269",
"R-HSA-4086400",
"R-HSA-4608870",
"R-HSA-4641258",
"R-HSA-4641262",
"R-HSA-5099900",
"R-HSA-5368598",
"R-HSA-5663220",
"R-HSA-8856825",
"R-HSA-8856828",
"R-HSA-9673324",
"R-MMU-201688",
"R-MMU-2028269",
"R-MMU-4086400",
"R-MMU-4608870"... | [
"REACTOME:R-HSA-201681",
"REACTOME:R-HSA-201688",
"REACTOME:R-HSA-2028269",
"REACTOME:R-HSA-4086400",
"REACTOME:R-HSA-4608870",
"REACTOME:R-HSA-4641258",
"REACTOME:R-HSA-4641262",
"REACTOME:R-HSA-5099900",
"REACTOME:R-HSA-5368598",
"REACTOME:R-HSA-5663220",
"REACTOME:R-HSA-8856825",
"REACTOME:... | 30 | [
"8wm9",
"8wma"
] | 2 | [
"PUB00050960",
"PUB00070944"
] | [
"19252499",
"15353129"
] | [
"Inhibition of Wnt signaling by Dishevelled PDZ peptides.",
"Characterization of function of three domains in dishevelled-1: DEP domain is responsible for membrane translocation of dishevelled-1."
] | [
2009,
2004
] | 2 | [
"IPR008339"
] | [] | 1 | 0 | 1 | [
"Tetrapoda"
] | [
342
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
5,
2,
2
] | 3 | true | Family | Dishevelled-2 | Dishevelled-2 | DVL2 | 1 |
IPR008342 | 8,342 | Dishevelled-3 | DVL3 | Family | 327 | false | false | Dishevelled (Dsh) proteins possess three conserved domains: an amino-terminal DIX domain, a central PDZ and a carboxyl-terminal DEP domain. They acts downstream of Fz receptors in the Wnt signalling pathway, which controls a variety of developmental and homeostatic events [ ]. Dishevelled-3 (DVL-3) may play a role in t... | [
"GO:0016055"
] | [
"Wnt signaling pathway"
] | [
"biological_process"
] | 1 | [
"PRINTS"
] | [
"PR01763"
] | [
"DISHEVELLED3"
] | [
327
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-201681",
"R-HSA-201688",
"R-HSA-4086400",
"R-HSA-4641258",
"R-HSA-4641262",
"R-HSA-5368598",
"R-HSA-5663220",
"R-HSA-9673324",
"R-MMU-201688",
"R-MMU-4086400",
"R-MMU-4641258",
"R-MMU-4641262",
"R-MMU-5663220"
] | [
"REACTOME:R-HSA-201681",
"REACTOME:R-HSA-201688",
"REACTOME:R-HSA-4086400",
"REACTOME:R-HSA-4641258",
"REACTOME:R-HSA-4641262",
"REACTOME:R-HSA-5368598",
"REACTOME:R-HSA-5663220",
"REACTOME:R-HSA-9673324",
"REACTOME:R-MMU-201688",
"REACTOME:R-MMU-4086400",
"REACTOME:R-MMU-4641258",
"REACTOME:R... | 13 | [] | 0 | [
"PUB00070944"
] | [
"15353129"
] | [
"Characterization of function of three domains in dishevelled-1: DEP domain is responsible for membrane translocation of dishevelled-1."
] | [
2004
] | 1 | [
"IPR008339"
] | [] | 1 | 0 | 1 | [
"Gnathostomata"
] | [
327
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
4,
3,
4
] | 3 | true | Family | Dishevelled-3 | Dishevelled-3 | DVL3 | 8 |
IPR008343 | 8,343 | Mitogen-activated protein (MAP) kinase phosphatase | MKP | Family | 9,044 | false | false | MAP Kinase Phosphatases (MKPs) are members of the dual specificity phosphatase family [ , ]. MKPs constitute a class of phosphatases that reverse the activation of MAP (mitogen activated protein) kinases by dephosphorylating critical tyrosine and threonine residues [ ]. This regulation is mediated via interaction of a ... | [
"GO:0017017",
"GO:0006470"
] | [
"MAP kinase tyrosine/serine/threonine phosphatase activity",
"protein dephosphorylation"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PIRSF",
"PRINTS"
] | [
"PIRSF000939",
"PR01764"
] | [
"MAPK_Ptase",
"MAPKPHPHTASE"
] | [
4133,
9032
] | 2 | [
"EC",
"EC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACT... | [
"3.1.3.16",
"3.1.3.48",
"R-BTA-112409",
"R-BTA-202670",
"R-BTA-5675221",
"R-CEL-112409",
"R-CEL-202670",
"R-CEL-5675221",
"R-DME-112409",
"R-DME-202670",
"R-DME-5675221",
"R-GGA-437980",
"R-GGA-437986",
"R-HSA-112409",
"R-HSA-202670",
"R-HSA-5675221",
"R-HSA-9636569",
"R-HSA-965281... | [
"EC:3.1.3.16",
"EC:3.1.3.48",
"REACTOME:R-BTA-112409",
"REACTOME:R-BTA-202670",
"REACTOME:R-BTA-5675221",
"REACTOME:R-CEL-112409",
"REACTOME:R-CEL-202670",
"REACTOME:R-CEL-5675221",
"REACTOME:R-DME-112409",
"REACTOME:R-DME-202670",
"REACTOME:R-DME-5675221",
"REACTOME:R-GGA-437980",
"REACTOME... | 24 | [
"1m3g",
"1mkp",
"1zzw",
"2g6z",
"2hxp",
"2oud",
"2vsw",
"3ezz",
"3lj8",
"3tg3",
"4jmk",
"4y2e",
"4yr8",
"6mc1",
"7u4o",
"7u4r",
"7umu",
"7umv",
"7un0",
"7un4",
"7y4c",
"7y4d",
"7y4e",
"9bpn",
"9bu4",
"9nsb",
"9nym",
"9o8w",
"9ok9",
"9q7x",
"9y55"
] | 31 | [
"PUB00011585",
"PUB00011587",
"PUB00056895",
"PUB00056896"
] | [
"8221888",
"8910287",
"17057753",
"15186772"
] | [
"MKP-1 (3CH134), an immediate early gene product, is a dual specificity phosphatase that dephosphorylates MAP kinase in vivo.",
"The dual specificity phosphatases M3/6 and MKP-3 are highly selective for inactivation of distinct mitogen-activated protein kinases.",
"Protein tyrosine phosphatases: from genes, to ... | [
1993,
1996,
2006,
2004
] | 4 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Megaviridae environmental sample"
] | [
9043,
1
] | 2 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
14,
3,
30,
33,
27
] | 6 | true | Family | Mitogen-activated protein (MAP) kinase phosphatase | Mitogen-activated protein (MAP) kinase phosphatase | MKP | 2 |
IPR008344 | 8,344 | Transient receptor potential cation channel subfamily V member 5/6 | TRPV5/TRPV6 | Family | 1,803 | false | false | Transient receptor potential (TRP) channels can be described as tetramers formed by subunits with six transmembrane domains and containing cation-selective pores, which in several cases show high calcium permeability. The molecular architecture of TRP channels is reminiscent of voltage-gated channels and comprises six ... | [
"GO:0005262",
"GO:0006816",
"GO:0016020"
] | [
"calcium channel activity",
"calcium ion transport",
"membrane"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PRINTS"
] | [
"PR01765"
] | [
"ECACCHANNEL"
] | [
1803
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-3295583",
"R-MMU-3295583",
"R-RNO-3295583"
] | [
"REACTOME:R-HSA-3295583",
"REACTOME:R-MMU-3295583",
"REACTOME:R-RNO-3295583"
] | 3 | [
"2rfa",
"5iwk",
"5iwp",
"5iwr",
"5iwt",
"5wo6",
"5wo7",
"5wo8",
"5wo9",
"5woa",
"6b5v",
"6bo8",
"6bo9",
"6boa",
"6bob",
"6d7o",
"6d7p",
"6d7q",
"6d7s",
"6d7t",
"6d7v",
"6d7x",
"6dmr",
"6dmu",
"6dmw",
"6e2f",
"6e2g",
"6o1n",
"6o1p",
"6o1u",
"6o20",
"6pbe"... | 68 | [
"PUB00054048",
"PUB00054049",
"PUB00054050",
"PUB00054054",
"PUB00100009"
] | [
"18535090",
"20025796",
"20861159",
"19297520",
"29464560"
] | [
"TRP channels entering the structural era.",
"Structure-functional intimacies of transient receptor potential channels.",
"The role of transient receptor potential cation channels in Ca2+ signaling.",
"Pharmacology of vanilloid transient receptor potential cation channels.",
"Transient Receptor Potential (T... | [
2008,
2009,
2010,
2009,
2018
] | 5 | [
"IPR024862"
] | [
"IPR008345",
"IPR008346"
] | 1 | 2 | 0 | [
"Bilateria"
] | [
1803
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
10,
6,
6
] | 4 | true | Family | Transient receptor potential cation channel subfamily V member 5/6 | Transient receptor potential cation channel subfamily V member 5/6 | TRPV5/TRPV6 | 7 |
IPR008345 | 8,345 | Transient receptor potential cation channel subfamily V member 6 | TrpV6 | Family | 276 | false | false | Transient receptor potential (TRP) channels can be described as tetramers formed by subunits with six transmembrane domains and containing cation-selective pores, which in several cases show high calcium permeability. The molecular architecture of TRP channels is reminiscent of voltage-gated channels and comprises six ... | [
"GO:0005262",
"GO:0006816",
"GO:0016020"
] | [
"calcium channel activity",
"calcium ion transport",
"membrane"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PRINTS"
] | [
"PR01766"
] | [
"ECACCHANNEL1"
] | [
276
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-3295583",
"R-MMU-3295583",
"R-RNO-3295583"
] | [
"REACTOME:R-HSA-3295583",
"REACTOME:R-MMU-3295583",
"REACTOME:R-RNO-3295583"
] | 3 | [
"5iwk",
"5iwp",
"5iwr",
"5iwt",
"5wo6",
"5wo7",
"5wo8",
"5wo9",
"5woa",
"6bo8",
"6bo9",
"6boa",
"6bob",
"6d7o",
"6d7p",
"6d7q",
"6d7s",
"6d7t",
"6d7v",
"6d7x",
"6e2f",
"6e2g",
"7d2k",
"7k4a",
"7k4b",
"7k4c",
"7k4d",
"7k4e",
"7k4f",
"7s88",
"7s89",
"7s8b"... | 40 | [
"PUB00018944",
"PUB00054048",
"PUB00054049",
"PUB00054050",
"PUB00054054",
"PUB00100009",
"PUB00100010",
"PUB00100011",
"PUB00100012",
"PUB00100013",
"PUB00100014",
"PUB00100015"
] | [
"11278579",
"18535090",
"20025796",
"20861159",
"19297520",
"29464560",
"11248124",
"23612980",
"11097838",
"15184369",
"29861107",
"29258289"
] | [
"Expression of CaT-like, a novel calcium-selective channel, correlates with the malignancy of prostate cancer.",
"TRP channels entering the structural era.",
"Structure-functional intimacies of transient receptor potential channels.",
"The role of transient receptor potential cation channels in Ca2+ signaling... | [
2001,
2008,
2009,
2010,
2009,
2018,
2001,
2013,
2000,
2004,
2018,
2018
] | 12 | [
"IPR008344"
] | [] | 1 | 0 | 1 | [
"Mammalia"
] | [
276
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
5,
4,
4
] | 3 | true | Family | Transient receptor potential cation channel subfamily V member 6 | Transient receptor potential cation channel subfamily V member 6 | TrpV6 | 9 |
IPR008347 | 8,347 | Transient receptor potential cation channel subfamily V member 1-4 | TrpV1-4 | Family | 5,065 | false | false | Transient receptor potential (TRP) channels can be described as tetramers formed by subunits with six transmembrane domains and containing cation-selective pores, which in several cases show high calcium permeability. The molecular architecture of TRP channels is reminiscent of voltage-gated channels and comprises six ... | [
"GO:0005216",
"GO:0006811",
"GO:0016020"
] | [
"monoatomic ion channel activity",
"monoatomic ion transport",
"membrane"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PRINTS"
] | [
"PR01768"
] | [
"TRPVRECEPTOR"
] | [
5065
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-CFA-3295583",
"R-HSA-3295583",
"R-HSA-9856530",
"R-MMU-3295583",
"R-MMU-9856530",
"R-RNO-3295583",
"R-RNO-9856530"
] | [
"REACTOME:R-CFA-3295583",
"REACTOME:R-HSA-3295583",
"REACTOME:R-HSA-9856530",
"REACTOME:R-MMU-3295583",
"REACTOME:R-MMU-9856530",
"REACTOME:R-RNO-3295583",
"REACTOME:R-RNO-9856530"
] | 7 | [
"2eta",
"2etb",
"2etc",
"2f37",
"2nyj",
"2pnn",
"3j5p",
"3j5q",
"3j5r",
"3j9j",
"3jxi",
"3jxj",
"3w9f",
"3w9g",
"4dx1",
"4dx2",
"4n5q",
"5an8",
"5hi9",
"5irx",
"5irz",
"5is0",
"6bbj",
"6bo4",
"6bo5",
"6bwj",
"6bwm",
"6c8f",
"6c8g",
"6c8h",
"6dvw",
"6dvy"... | 166 | [
"PUB00054048",
"PUB00054049",
"PUB00054050",
"PUB00054054",
"PUB00100009"
] | [
"18535090",
"20025796",
"20861159",
"19297520",
"29464560"
] | [
"TRP channels entering the structural era.",
"Structure-functional intimacies of transient receptor potential channels.",
"The role of transient receptor potential cation channels in Ca2+ signaling.",
"Pharmacology of vanilloid transient receptor potential cation channels.",
"Transient Receptor Potential (T... | [
2008,
2009,
2010,
2009,
2018
] | 5 | [
"IPR024862"
] | [
"IPR008348"
] | 1 | 1 | 0 | [
"Opisthokonta"
] | [
5065
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
9,
25,
15,
18
] | 4 | true | Family | Transient receptor potential cation channel subfamily V member 1-4 | Transient receptor potential cation channel subfamily V member 1-4 | TrpV1-4 | 8 |
IPR008348 | 8,348 | Transient receptor potential cation channel subfamily V member 4 | TrpV4 | Family | 1,890 | false | false | Transient receptor potential (TRP) channels can be described as tetramers formed by subunits with six transmembrane domains and containing cation-selective pores, which in several cases show high calcium permeability. The molecular architecture of TRP channels is reminiscent of voltage-gated channels and comprises six ... | [
"GO:0005216",
"GO:0006811",
"GO:0016020"
] | [
"monoatomic ion channel activity",
"monoatomic ion transport",
"membrane"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PRINTS"
] | [
"PR01769"
] | [
"VRL2RECEPTOR"
] | [
1890
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-3295583",
"R-HSA-9856530",
"R-MMU-3295583",
"R-MMU-9856530",
"R-RNO-3295583",
"R-RNO-9856530"
] | [
"REACTOME:R-HSA-3295583",
"REACTOME:R-HSA-9856530",
"REACTOME:R-MMU-3295583",
"REACTOME:R-MMU-9856530",
"REACTOME:R-RNO-3295583",
"REACTOME:R-RNO-9856530"
] | 6 | [
"6bbj",
"8fc7",
"8fc8",
"8fc9",
"8fca",
"8fcb",
"8j1b",
"8j1d",
"8j1f",
"8j1h",
"8jkm",
"9iqx",
"9iqy"
] | 13 | [
"PUB00011598",
"PUB00054048",
"PUB00054049",
"PUB00054050",
"PUB00054054",
"PUB00056698",
"PUB00056699",
"PUB00056700",
"PUB00100009",
"PUB00100016",
"PUB00100017",
"PUB00100018",
"PUB00100019",
"PUB00100020"
] | [
"11081638",
"18535090",
"20025796",
"20861159",
"19297520",
"11827975",
"12151520",
"17233610",
"29464560",
"21336783",
"29899501",
"18695040",
"18826956",
"31493693"
] | [
"Vanilloid receptor-related osmotically activated channel (VR-OAC), a candidate vertebrate osmoreceptor.",
"TRP channels entering the structural era.",
"Structure-functional intimacies of transient receptor potential channels.",
"The role of transient receptor potential cation channels in Ca2+ signaling.",
... | [
2000,
2008,
2009,
2010,
2009,
2002,
2002,
2007,
2018,
2011,
2018,
2008,
2008,
2020
] | 14 | [
"IPR008347"
] | [] | 1 | 0 | 1 | [
"Gnathostomata"
] | [
1890
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
4,
3,
5,
5
] | 4 | true | Family | Transient receptor potential cation channel subfamily V member 4 | Transient receptor potential cation channel subfamily V member 4 | TrpV4 | 4 |
IPR008349 | 8,349 | Mitogen-activated protein (MAP) kinase, ERK1/2 | MAPK_ERK1/2 | Family | 3,247 | false | false | Protein phosphorylation, which plays a key role in most cellular activities, is a reversible process mediated by protein kinases and phosphoprotein phosphatases. Protein kinases catalyse the transfer of the gamma phosphate from nucleotide triphosphates (often ATP) to one or more amino acid residues in a protein substra... | [
"GO:0004707",
"GO:0005524",
"GO:0006468"
] | [
"MAP kinase activity",
"ATP binding",
"protein phosphorylation"
] | [
"molecular_function",
"molecular_function",
"biological_process"
] | 3 | [
"PRINTS"
] | [
"PR01770"
] | [
"ERK1ERK2MAPK"
] | [
3247
] | 1 | [
"EC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
... | [
"2.7.11.24",
"R-BTA-111995",
"R-BTA-112409",
"R-BTA-112411",
"R-BTA-1181150",
"R-BTA-1295596",
"R-BTA-1502540",
"R-BTA-162658",
"R-BTA-170968",
"R-BTA-198753",
"R-BTA-202670",
"R-BTA-2029482",
"R-BTA-2173795",
"R-BTA-2173796",
"R-BTA-2559580",
"R-BTA-2559582",
"R-BTA-2559585",
"R-B... | [
"EC:2.7.11.24",
"REACTOME:R-BTA-111995",
"REACTOME:R-BTA-112409",
"REACTOME:R-BTA-112411",
"REACTOME:R-BTA-1181150",
"REACTOME:R-BTA-1295596",
"REACTOME:R-BTA-1502540",
"REACTOME:R-BTA-162658",
"REACTOME:R-BTA-170968",
"REACTOME:R-BTA-198753",
"REACTOME:R-BTA-202670",
"REACTOME:R-BTA-2029482",... | 281 | [
"1gol",
"1pme",
"1tvo",
"1wzy",
"2erk",
"2fys",
"2gph",
"2ojg",
"2oji",
"2ojj",
"2y9q",
"2z7l",
"2zoq",
"3c9w",
"3erk",
"3i5z",
"3i60",
"3o71",
"3qyw",
"3qyz",
"3r63",
"3sa0",
"3tei",
"3w55",
"3zu7",
"3zuv",
"4erk",
"4fmq",
"4fux",
"4fuy",
"4fv0",
"4fv1"... | 235 | [
"PUB00005115",
"PUB00007546",
"PUB00011603",
"PUB00015362",
"PUB00020114",
"PUB00034898",
"PUB00034899"
] | [
"3291115",
"8607979",
"10487205",
"12368087",
"12471243",
"15078142",
"15320712"
] | [
"The protein kinase family: conserved features and deduced phylogeny of the catalytic domains.",
"Dynamics and organization of MAP kinase signal pathways.",
"The stress-activated protein kinase pathways.",
"Evolution of protein kinase signaling from yeast to man.",
"The protein kinase complement of the huma... | [
1988,
1995,
1999,
2002,
2002,
2004,
2004
] | 7 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
3247
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
3,
3,
16,
10,
6
] | 6 | true | Family | Mitogen-activated protein (MAP) kinase, ERK1/2 | Mitogen-activated protein (MAP) kinase, ERK1/2 | MAPK_ERK1/2 | 6 |
IPR008350 | 8,350 | Mitogen-activated protein (MAP) kinase, ERK3/4 | MAPK_ERK3/4 | Family | 2,222 | false | false | Protein phosphorylation, which plays a key role in most cellular activities, is a reversible process mediated by protein kinases and phosphoprotein phosphatases. Protein kinases catalyse the transfer of the gamma phosphate from nucleotide triphosphates (often ATP) to one or more amino acid residues in a protein substra... | [
"GO:0004707",
"GO:0005524",
"GO:0006468"
] | [
"MAP kinase activity",
"ATP binding",
"protein phosphorylation"
] | [
"molecular_function",
"molecular_function",
"biological_process"
] | 3 | [
"PRINTS"
] | [
"PR01771"
] | [
"ERK3ERK4MAPK"
] | [
2222
] | 1 | [
"EC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"2.7.11.24",
"R-GGA-5687128",
"R-HSA-5687128",
"R-MMU-5687128",
"R-RNO-5687128"
] | [
"EC:2.7.11.24",
"REACTOME:R-GGA-5687128",
"REACTOME:R-HSA-5687128",
"REACTOME:R-MMU-5687128",
"REACTOME:R-RNO-5687128"
] | 5 | [
"6yky",
"6ylc",
"6yll",
"7aqb"
] | 4 | [
"PUB00005115",
"PUB00011603",
"PUB00011604",
"PUB00015362",
"PUB00020114",
"PUB00034898",
"PUB00034899"
] | [
"3291115",
"10487205",
"10657254",
"12368087",
"12471243",
"15078142",
"15320712"
] | [
"The protein kinase family: conserved features and deduced phylogeny of the catalytic domains.",
"The stress-activated protein kinase pathways.",
"Cloning and characterization of mouse extracellular-signal-regulated protein kinase 3 as a unique gene product of 100 kDa.",
"Evolution of protein kinase signaling... | [
1988,
1999,
2000,
2002,
2002,
2004,
2004
] | 7 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
2222
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
5,
6,
7,
6
] | 4 | true | Family | Mitogen-activated protein (MAP) kinase, ERK3/4 | Mitogen-activated protein (MAP) kinase, ERK3/4 | MAPK_ERK3/4 | 3 |
IPR008351 | 8,351 | Mitogen-activated protein (MAP) kinase, JNK | MAPK_JNK | Family | 8,083 | false | false | MAP (Mitogen Activated Protein) kinases participate in kinase cascades, whereby at least 3 protein kinases act in series, culminating in activation of MAP kinase [ ]. MAP kinases are activated by dual phosphorylation on both tyrosine and threonine residues of a conserved TXY motif. JNK (Jun N-terminal Kinase), also kno... | [
"GO:0004707",
"GO:0005524",
"GO:0006468"
] | [
"MAP kinase activity",
"ATP binding",
"protein phosphorylation"
] | [
"molecular_function",
"molecular_function",
"biological_process"
] | 3 | [
"PRINTS"
] | [
"PR01772"
] | [
"JNKMAPKINASE"
] | [
8083
] | 1 | [
"EC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
... | [
"2.7.11.24",
"R-CEL-193648",
"R-CEL-2559580",
"R-CEL-2871796",
"R-CEL-450321",
"R-CEL-450341",
"R-CEL-9007892",
"R-DME-193648",
"R-DME-209397",
"R-DME-209409",
"R-DME-209425",
"R-DME-209459",
"R-DME-2559580",
"R-DME-2871796",
"R-DME-450321",
"R-DME-450341",
"R-DME-9007892",
"R-DRE-... | [
"EC:2.7.11.24",
"REACTOME:R-CEL-193648",
"REACTOME:R-CEL-2559580",
"REACTOME:R-CEL-2871796",
"REACTOME:R-CEL-450321",
"REACTOME:R-CEL-450341",
"REACTOME:R-CEL-9007892",
"REACTOME:R-DME-193648",
"REACTOME:R-DME-209397",
"REACTOME:R-DME-209409",
"REACTOME:R-DME-209425",
"REACTOME:R-DME-209459",
... | 58 | [
"1jnk",
"1pmn",
"1pmu",
"1pmv",
"1ukh",
"1uki",
"2b1p",
"2exc",
"2g01",
"2gmx",
"2h96",
"2no3",
"2o0u",
"2o2u",
"2ok1",
"2p33",
"2r9s",
"2waj",
"2xrw",
"2xs0",
"2zdt",
"2zdu",
"3cgf",
"3cgo",
"3da6",
"3e7o",
"3elj",
"3fi2",
"3fi3",
"3fv8",
"3g90",
"3g9l"... | 108 | [
"PUB00008480",
"PUB00011603",
"PUB00060226",
"PUB00075320"
] | [
"11790549",
"10487205",
"12074577",
"25500773"
] | [
"The JNK signal transduction pathway.",
"The stress-activated protein kinase pathways.",
"Isolation of novel rice (Oryza sativa L.) multiple stress responsive MAP kinase gene, OsMSRMK2, whose mRNA accumulates rapidly in response to environmental cues.",
"The JNK-like MAPK KGB-1 of Caenorhabditis elegans promo... | [
2002,
1999,
2002,
2014
] | 4 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
8083
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
3,
67,
3,
49,
22,
1,
26,
5
] | 8 | true | Family | Mitogen-activated protein (MAP) kinase, JNK | Mitogen-activated protein (MAP) kinase, JNK | MAPK_JNK | 1 |
IPR008352 | 8,352 | Mitogen-activated protein (MAP) kinase HOG-like | MAPK_HOG-like | Family | 9,400 | false | false | This entry represents MAP kinases including HOG1, MAP 14/13/12 and similar MAP kinases. Hog1 is the key element in the high osmolarity glycerol (HOG) pathway and is activated upon hyperosmotic stress. Activated Hog1 accumulates in the nucleus and regulates stress-induced transcription [ ]. The HOG pathway is mediated b... | [
"GO:0004707",
"GO:0005524",
"GO:0006468"
] | [
"MAP kinase activity",
"ATP binding",
"protein phosphorylation"
] | [
"molecular_function",
"molecular_function",
"biological_process"
] | 3 | [
"PRINTS"
] | [
"PR01773"
] | [
"P38MAPKINASE"
] | [
9400
] | 1 | [
"EC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
... | [
"2.7.11.24",
"R-CEL-168638",
"R-CEL-171007",
"R-CEL-198753",
"R-CEL-2559580",
"R-CEL-418592",
"R-CEL-432142",
"R-CEL-4420097",
"R-CEL-450302",
"R-CEL-450341",
"R-CEL-525793",
"R-CEL-5675221",
"R-CEL-6798695",
"R-CFA-168638",
"R-CFA-198753",
"R-CFA-418592",
"R-CFA-432142",
"R-CFA-44... | [
"EC:2.7.11.24",
"REACTOME:R-CEL-168638",
"REACTOME:R-CEL-171007",
"REACTOME:R-CEL-198753",
"REACTOME:R-CEL-2559580",
"REACTOME:R-CEL-418592",
"REACTOME:R-CEL-432142",
"REACTOME:R-CEL-4420097",
"REACTOME:R-CEL-450302",
"REACTOME:R-CEL-450341",
"REACTOME:R-CEL-525793",
"REACTOME:R-CEL-5675221",
... | 163 | [
"1a9u",
"1bl6",
"1bl7",
"1bmk",
"1cm8",
"1di9",
"1ian",
"1kv1",
"1kv2",
"1lew",
"1lez",
"1m7q",
"1ouk",
"1ouy",
"1ove",
"1oz1",
"1r39",
"1r3c",
"1w7h",
"1w82",
"1w83",
"1w84",
"1wbn",
"1wbo",
"1wbs",
"1wbt",
"1wbv",
"1wbw",
"1wfc",
"1yqj",
"1yw2",
"1ywr"... | 403 | [
"PUB00005115",
"PUB00011603",
"PUB00011605",
"PUB00015362",
"PUB00020114",
"PUB00034898",
"PUB00034899",
"PUB00085486",
"PUB00088415"
] | [
"3291115",
"10487205",
"12452429",
"12368087",
"12471243",
"15078142",
"15320712",
"16778768",
"29085028"
] | [
"The protein kinase family: conserved features and deduced phylogeny of the catalytic domains.",
"The stress-activated protein kinase pathways.",
"In the cellular garden of forking paths: how p38 MAPKs signal for downstream assistance.",
"Evolution of protein kinase signaling from yeast to man.",
"The prote... | [
1988,
1999,
2002,
2002,
2002,
2004,
2004,
2006,
2017
] | 9 | [
"IPR050117"
] | [
"IPR038783",
"IPR038784",
"IPR038785",
"IPR038786"
] | 1 | 4 | 0 | [
"Eukaryota"
] | [
9400
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strai... | [
4,
15,
3,
17,
12,
2,
22,
1,
2
] | 9 | true | Family | Mitogen-activated protein (MAP) kinase HOG-like | Mitogen-activated protein (MAP) kinase HOG-like | MAPK_HOG-like | 5 |
IPR008353 | 8,353 | Peptidase S1B, exfoliative toxin | Peptidase_S1B_tx | Family | 745 | false | false | This group of serine peptidases belong to MEROPS peptidase family S1, subfamily S1B (clan PA(S)). The type example is glutamyl endopeptidase I of Staphylococcus aureus, a well-characterised and specialised human pathogen expressing a variety of virulence factors to enable successful infection of the host. Symptoms usua... | [
"GO:0004252",
"GO:0006508"
] | [
"serine-type endopeptidase activity",
"proteolysis"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PRINTS"
] | [
"PR01774"
] | [
"EXFOLTOXIN"
] | [
745
] | 1 | [
"EC",
"METACYC"
] | [
"3.4.21.-",
"PWY-7884"
] | [
"EC:3.4.21.-",
"METACYC:PWY-7884"
] | 2 | [
"1agj",
"1dt2",
"1dua",
"1due",
"1exf",
"1qtf",
"1qy6",
"1wcz",
"2as9",
"2o8l",
"2vid",
"2w7s",
"2w7u",
"3ufa",
"4jcn",
"4k1s",
"4k1t",
"4mvn",
"5c2z",
"5mm8",
"6e0u",
"6pym",
"6q12",
"6q24",
"6tya",
"6u1b",
"6yv5",
"6yv6",
"8dax",
"8t3i",
"8t3j",
"9bsh"... | 35 | [
"PUB00011606",
"PUB00011608",
"PUB00011609"
] | [
"10627489",
"11544350",
"10194458"
] | [
"Exotoxins of Staphylococcus aureus.",
"Toxic shock syndrome and bacterial superantigens: an update.",
"Clinical, microbial, and biochemical aspects of the exfoliative toxins causing staphylococcal scalded-skin syndrome."
] | [
2000,
2001,
1999
] | 3 | [
"IPR008256"
] | [] | 1 | 0 | 1 | [
"Bacteria",
"Bilateria",
"Caudoviricetes",
"Methanosarcina",
"human gut metagenome"
] | [
729,
2,
7,
6,
1
] | 5 | [] | [] | 0 | true | Family | Peptidase S1B, exfoliative toxin | Peptidase S1B, exfoliative toxin | Peptidase_S1B_tx | 4 |
IPR008356 | 8,356 | Protein-tyrosine phosphatase, KIM-containing | Tyr_Pase_KIM-con | Family | 4,386 | false | false | Protein tyrosine (pTyr) phosphorylation is a common post-translational modification which can create novel recognition motifs for protein interactions and cellular localisation, affect protein stability, and regulate enzyme activity. Consequently, maintaining an appropriate level of protein tyrosine phosphorylation is ... | [
"GO:0004725",
"GO:0006470"
] | [
"protein tyrosine phosphatase activity",
"protein dephosphorylation"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PRINTS",
"PANTHER"
] | [
"PR01778",
"PTHR46198"
] | [
"KIMPTPASE",
""
] | [
3801,
4379
] | 2 | [
"EC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"3.1.3.48",
"R-HSA-5675221",
"R-HSA-9008059",
"R-MMU-5675221",
"R-RNO-5675221"
] | [
"EC:3.1.3.48",
"REACTOME:R-HSA-5675221",
"REACTOME:R-HSA-9008059",
"REACTOME:R-MMU-5675221",
"REACTOME:R-RNO-5675221"
] | 5 | [
"1jln",
"1zc0",
"2a3k",
"2a8b",
"2bij",
"2bv5",
"2cjz",
"2gp0",
"2hvl",
"2qdc",
"2qdm",
"2qdp",
"3d42",
"3d44",
"3o4s",
"3o4t",
"3o4u",
"5ovr",
"5ovx",
"5ow1",
"6h8r",
"6h8s",
"8sls",
"8slt",
"8slu",
"9eex",
"9eey",
"9eez"
] | 28 | [
"PUB00011676",
"PUB00035793",
"PUB00035794",
"PUB00035795",
"PUB00035796",
"PUB00035797",
"PUB00035798"
] | [
"9857190",
"9818190",
"14625689",
"12678841",
"16672235",
"8948575",
"9646865"
] | [
"PTP-SL and STEP protein tyrosine phosphatases regulate the activation of the extracellular signal-regulated kinases ERK1 and ERK2 by association through a kinase interaction motif.",
"Protein tyrosine phosphatases: mechanisms of catalysis and regulation.",
"Receptor and nonreceptor protein tyrosine phosphatase... | [
1998,
1998,
2003,
2003,
2006,
1996,
1998
] | 7 | [] | [
"IPR016334"
] | 0 | 1 | 0 | [
"Opisthokonta"
] | [
4386
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
4,
2,
33,
13,
23
] | 5 | true | Family | Protein-tyrosine phosphatase, KIM-containing | Protein-tyrosine phosphatase, KIM-containing | Tyr_Pase_KIM-con | 1 |
IPR008357 | 8,357 | Lantibiotic leader peptide-processing serine protease | Lanit_process | Family | 309 | false | false | Lantibiotic genes reside on the bacterial chromosome, where they cluster with genes that adapt and secrete them to the extracellular space. Many of these so-called 'pathogenicity islands' have been characterised, including the epidermin (epi) cluster in Staphylococcus epidermis, and the nisin (nis) cluster in Lactococc... | [
"GO:0004252",
"GO:0006508"
] | [
"serine-type endopeptidase activity",
"proteolysis"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PIRSF",
"PRINTS",
"CDD"
] | [
"PIRSF037875",
"PR01779",
"cd07482"
] | [
"Peptidase_S8_lp",
"LANTIPROCESS",
"Peptidases_S8_Lantibiotic_specific_protease"
] | [
137,
242,
236
] | 3 | [] | [] | [] | 0 | [
"3qfh",
"3t41",
"4mzd"
] | 3 | [
"PUB00011677",
"PUB00011678",
"PUB00011679",
"PUB00081192",
"PUB00081193"
] | [
"11133423",
"12066186",
"8478324",
"8550430",
"10473390"
] | [
"The group I strain of Streptococcus mutans, UA140, produces both the lantibiotic mutacin I and a nonlantibiotic bacteriocin, mutacin IV.",
"Modulation of virulence within a pathogenicity island in vancomycin-resistant Enterococcus faecalis.",
"Characterization of the Lactococcus lactis nisin A operon genes nis... | [
2001,
2002,
1993,
1996,
1999
] | 5 | [
"IPR015500"
] | [] | 1 | 0 | 1 | [
"Bacteria"
] | [
309
] | 1 | [] | [] | 0 | true | Family | Lantibiotic leader peptide-processing serine protease | Lantibiotic leader peptide-processing serine protease | Lanit_process | 6 |
IPR008358 | 8,358 | Signal transduction histidine kinase/phosphatase, lantibiotic regulatory protein MprB | Sig_transdc_His_kin/Pase_MprB | Family | 2,031 | false | false | Two-component signal transduction systems enable bacteria to sense, respond, and adapt to a wide range of environments, stressors, and growth conditions [ ]. Some bacteria can contain up to as many as 200 two-component systems that need tight regulation to prevent unwanted cross-talk [ ]. These pathways have been adapt... | [
"GO:0000155",
"GO:0004673",
"GO:0000160",
"GO:0016020"
] | [
"phosphorelay sensor kinase activity",
"protein histidine kinase activity",
"phosphorelay signal transduction system",
"membrane"
] | [
"molecular_function",
"molecular_function",
"biological_process",
"cellular_component"
] | 4 | [
"PRINTS"
] | [
"PR01780"
] | [
"LANTIREGPROT"
] | [
2031
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00000966",
"PUB00007866",
"PUB00010651",
"PUB00011096",
"PUB00011679",
"PUB00011680",
"PUB00013246",
"PUB00013247",
"PUB00013562",
"PUB00013563",
"PUB00020801",
"PUB00042804",
"PUB00042805",
"PUB00042806",
"PUB00042807"
] | [
"9989504",
"11406410",
"12372152",
"10966457",
"8478324",
"8161176",
"8868347",
"10426948",
"8029829",
"1482126",
"11145881",
"16176121",
"18076326",
"11934609",
"11489844"
] | [
"Structure of CheA, a signal-transducing histidine kinase.",
"Histidine kinases and response regulator proteins in two-component signaling systems.",
"Histidine protein kinases: key signal transducers outside the animal kingdom.",
"Two-component signal transduction.",
"Characterization of the Lactococcus la... | [
1999,
2001,
2002,
2000,
1993,
1994,
1996,
1999,
1994,
1992,
2000,
2005,
2007,
2002,
2001
] | 15 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Ichthyophthirius multifiliis",
"Siphoviridae sp. cto3L1",
"metagenomes"
] | [
2016,
1,
1,
13
] | 4 | [] | [] | 0 | true | Family | Signal transduction histidine kinase/phosphatase, lantibiotic regulatory protein MprB | Signal transduction histidine kinase/phosphatase, lantibiotic regulatory protein MprB | Sig_transdc_His_kin/Pase_MprB | 9 |
IPR008359 | 8,359 | Linker-for-activation of T cells (LAT) protein | Linker_for_activat_Tcells_prot | Family | 370 | false | false | A key event in the regulation of the adaptive immune response is the binding of major histocompatibility complex (MHC)-peptide complexes to T cell antigen receptors (TCRs). The formation of such ternary complexes induces significant biochemical changes within T cells of the host animal. The first detectable response of... | [
"GO:0007165",
"GO:0016020"
] | [
"signal transduction",
"membrane"
] | [
"biological_process",
"cellular_component"
] | 2 | [
"PFAM",
"PRINTS",
"PANTHER"
] | [
"PF15234",
"PR01781",
"PTHR15586"
] | [
"LAT",
"LATPROTEIN",
""
] | [
370,
313,
350
] | 3 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-114604",
"R-HSA-202433",
"R-HSA-2424491",
"R-HSA-2454202",
"R-HSA-2871796",
"R-HSA-2871809",
"R-HSA-5673001",
"R-MMU-114604",
"R-MMU-202433",
"R-MMU-2424491",
"R-MMU-2454202",
"R-MMU-2871796",
"R-MMU-2871809",
"R-MMU-5673001",
"R-RNO-114604",
"R-RNO-202433",
"R-RNO-2424491",
... | [
"REACTOME:R-HSA-114604",
"REACTOME:R-HSA-202433",
"REACTOME:R-HSA-2424491",
"REACTOME:R-HSA-2454202",
"REACTOME:R-HSA-2871796",
"REACTOME:R-HSA-2871809",
"REACTOME:R-HSA-5673001",
"REACTOME:R-MMU-114604",
"REACTOME:R-MMU-202433",
"REACTOME:R-MMU-2424491",
"REACTOME:R-MMU-2454202",
"REACTOME:R-... | 21 | [] | 0 | [
"PUB00011681"
] | [
"11756537"
] | [
"Effect of redox balance alterations on cellular localization of LAT and downstream T-cell receptor signaling pathways."
] | [
2002
] | 1 | [] | [] | 0 | 0 | null | [
"Euteleostomi"
] | [
370
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
5,
6,
6
] | 3 | true | Family | Linker-for-activation of T cells (LAT) protein | Linker-for-activation of T cells (LAT) protein | Linker_for_activat_Tcells_prot | 7 |
IPR008361 | 8,361 | Melanin-concentrating hormone receptor | MCH_rcpt | Family | 1,340 | false | false | G protein-coupled receptors (GPCRs) constitute a vast protein family that encompasses a wide range of functions, including various autocrine, paracrine and endocrine processes. They show considerable diversity at the sequence level, on the basis of which they can be separated into distinct groups [ ]. The term clan can... | [
"GO:0007186",
"GO:0016020"
] | [
"G protein-coupled receptor signaling pathway",
"membrane"
] | [
"biological_process",
"cellular_component"
] | 2 | [
"PRINTS"
] | [
"PR01783"
] | [
"MCHRECEPTOR"
] | [
1340
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-375276",
"R-HSA-416476",
"R-HSA-418594",
"R-HSA-5620922",
"R-MMU-375276",
"R-MMU-416476",
"R-MMU-418594",
"R-MMU-5620922",
"R-RNO-375276",
"R-RNO-416476",
"R-RNO-418594",
"R-RNO-5620922",
"R-SSC-375276",
"R-SSC-416476",
"R-SSC-418594",
"R-SSC-5620922"
] | [
"REACTOME:R-HSA-375276",
"REACTOME:R-HSA-416476",
"REACTOME:R-HSA-418594",
"REACTOME:R-HSA-5620922",
"REACTOME:R-MMU-375276",
"REACTOME:R-MMU-416476",
"REACTOME:R-MMU-418594",
"REACTOME:R-MMU-5620922",
"REACTOME:R-RNO-375276",
"REACTOME:R-RNO-416476",
"REACTOME:R-RNO-418594",
"REACTOME:R-RNO-5... | 16 | [
"8wss",
"8wst",
"8wwh",
"8wwi",
"8wwj",
"8wwk",
"8wwl",
"8wwm",
"8wwn",
"8yns",
"8ynt"
] | 11 | [
"PUB00000131",
"PUB00002477",
"PUB00004960",
"PUB00004961",
"PUB00007849",
"PUB00053635",
"PUB00063577",
"PUB00063578",
"PUB00063579",
"PUB00063580",
"PUB00063816"
] | [
"2111655",
"2830256",
"8386361",
"8170923",
"10421368",
"12679517",
"8081729",
"15914470",
"18948278",
"16753280",
"23020293"
] | [
"G proteins in signal transduction.",
"G protein involvement in receptor-effector coupling.",
"Design of a discriminating fingerprint for G-protein-coupled receptors.",
"Fingerprinting G-protein-coupled receptors.",
"Molecular characterization of the melanin-concentrating-hormone receptor.",
"The G protei... | [
1990,
1988,
1993,
1994,
1999,
2003,
1994,
2005,
2009,
2006,
2013
] | 11 | [
"IPR000276"
] | [
"IPR004047",
"IPR008362"
] | 1 | 2 | 0 | [
"Deuterostomia"
] | [
1340
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
7,
5,
1,
1
] | 4 | true | Family | Melanin-concentrating hormone receptor | Melanin-concentrating hormone receptor | MCH_rcpt | 1 |
IPR008362 | 8,362 | Melanin-concentrating hormone receptor 2 | MCHR2 | Family | 313 | false | false | This entry represents a group of proteins from vertebrates, including human Melanin-concentrating hormone receptor 2 (MCHR2 or MCH2). Melanin-concentrating hormone (MCH) is a cyclic peptide originally identified in teleost fish [ ]. In fish, MCH is released from the pituitary and causes lightening of skin pigment cells... | [
"GO:0007186",
"GO:0016020"
] | [
"G protein-coupled receptor signaling pathway",
"membrane"
] | [
"biological_process",
"cellular_component"
] | 2 | [
"PRINTS",
"CDD"
] | [
"PR01784",
"cd15339"
] | [
"MCH2RECEPTOR",
"7tmA_MCHR2"
] | [
311,
229
] | 2 | [
"IUPHAR",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"281",
"R-HSA-375276",
"R-HSA-416476",
"R-HSA-418594"
] | [
"IUPHAR:281",
"REACTOME:R-HSA-375276",
"REACTOME:R-HSA-416476",
"REACTOME:R-HSA-418594"
] | 4 | [
"8wst"
] | 1 | [
"PUB00000131",
"PUB00002477",
"PUB00004960",
"PUB00004961",
"PUB00007849",
"PUB00053635",
"PUB00063577",
"PUB00063578",
"PUB00063579",
"PUB00063580",
"PUB00063816",
"PUB00087043",
"PUB00087044",
"PUB00092609",
"PUB00092610",
"PUB00092615",
"PUB00092616",
"PUB00092621",
"PUB000926... | [
"2111655",
"2830256",
"8386361",
"8170923",
"10421368",
"12679517",
"8081729",
"15914470",
"18948278",
"16753280",
"23020293",
"23237917",
"18957321",
"20940434",
"22503476",
"24386514",
"23140243",
"19458711",
"23251911",
"22032986",
"23407534",
"22975406",
"23445222",
... | [
"G proteins in signal transduction.",
"G protein involvement in receptor-effector coupling.",
"Design of a discriminating fingerprint for G-protein-coupled receptors.",
"Fingerprinting G-protein-coupled receptors.",
"Molecular characterization of the melanin-concentrating-hormone receptor.",
"The G protei... | [
1990,
1988,
1993,
1994,
1999,
2003,
1994,
2005,
2009,
2006,
2013,
2013,
2008,
2010,
2012,
2013,
2013,
2009,
2012,
2012,
2013,
2013,
2013,
2005
] | 24 | [
"IPR008361"
] | [] | 1 | 0 | 1 | [
"Chordata"
] | [
313
] | 1 | [
"Danio rerio",
"Homo sapiens"
] | [
4,
1
] | 2 | true | Family | Melanin-concentrating hormone receptor 2 | Melanin-concentrating hormone receptor 2 | MCHR2 | 3 |
IPR008363 | 8,363 | Paraoxonase1 | Paraoxonase1 | Family | 220 | false | false | The serum paraoxonases/arylesterases are enzymes that catalyse the hydrolysis of the toxic metabolites of a variety of organophosphorus insecticides. The enzymes hydrolyse a broad spectrum of organophosphate substrates, including paraoxon and a number of aromatic carboxylic acid esters (e.g., phenyl acetate), and hence... | [
"GO:0004064",
"GO:0005576"
] | [
"arylesterase activity",
"extracellular region"
] | [
"molecular_function",
"cellular_component"
] | 2 | [
"PRINTS"
] | [
"PR01786"
] | [
"PARAOXONASE1"
] | [
220
] | 1 | [
"EC",
"EC",
"EC",
"METACYC",
"METACYC",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"3.1.1.2",
"3.1.1.81",
"3.1.8.1",
"PWY-5489",
"PWY-5490",
"PWY-8065",
"R-HSA-2142688",
"R-HSA-9754706",
"R-MMU-2142688",
"R-MMU-9754706",
"R-RNO-2142688",
"R-RNO-9754706"
] | [
"EC:3.1.1.2",
"EC:3.1.1.81",
"EC:3.1.8.1",
"METACYC:PWY-5489",
"METACYC:PWY-5490",
"METACYC:PWY-8065",
"REACTOME:R-HSA-2142688",
"REACTOME:R-HSA-9754706",
"REACTOME:R-MMU-2142688",
"REACTOME:R-MMU-9754706",
"REACTOME:R-RNO-2142688",
"REACTOME:R-RNO-9754706"
] | 12 | [
"1v04",
"3sre",
"3srg",
"4hho",
"4hhq",
"4q1u",
"6g82",
"6gmu",
"6h0a",
"9r0q"
] | 10 | [
"PUB00001973",
"PUB00007849",
"PUB00011231",
"PUB00011685"
] | [
"8661009",
"10421368",
"11038162",
"7749820"
] | [
"The human serum paraoxonase/arylesterase gene (PON1) is one member of a multigene family.",
"Molecular characterization of the melanin-concentrating-hormone receptor.",
"Human serum paraoxonase (PON1) isozymes Q and R hydrolyze lactones and cyclic carbonate esters.",
"A polymorphism of the paraoxonase gene a... | [
1996,
1999,
2000,
1995
] | 4 | [
"IPR002640"
] | [] | 1 | 0 | 1 | [
"Eutheria"
] | [
220
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
3,
6
] | 3 | true | Family | Paraoxonase1 | Paraoxonase1 | Paraoxonase1 | 3 |
IPR008364 | 8,364 | Paraoxonase2 | Paraoxonase2 | Family | 508 | false | false | The serum paraoxonases/arylesterases are enzymes that catalyse the hydrolysis of the toxic metabolites of a variety of organophosphorus insecticides. The enzymes hydrolyse a broad spectrum of organophosphate substrates, including paraoxon and a number of aromatic carboxylic acid esters (e.g., phenyl acetate), and hence... | [
"GO:0004064",
"GO:0005576"
] | [
"arylesterase activity",
"extracellular region"
] | [
"molecular_function",
"cellular_component"
] | 2 | [
"PRINTS"
] | [
"PR01787"
] | [
"PARAOXONASE2"
] | [
508
] | 1 | [
"EC",
"EC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"3.1.1.2",
"3.1.1.81",
"R-BTA-2142688",
"R-HSA-2142688",
"R-HSA-9754706",
"R-MMU-2142688",
"R-MMU-9754706",
"R-RNO-2142688",
"R-RNO-9754706"
] | [
"EC:3.1.1.2",
"EC:3.1.1.81",
"REACTOME:R-BTA-2142688",
"REACTOME:R-HSA-2142688",
"REACTOME:R-HSA-9754706",
"REACTOME:R-MMU-2142688",
"REACTOME:R-MMU-9754706",
"REACTOME:R-RNO-2142688",
"REACTOME:R-RNO-9754706"
] | 9 | [] | 0 | [
"PUB00001973",
"PUB00011231"
] | [
"8661009",
"11038162"
] | [
"The human serum paraoxonase/arylesterase gene (PON1) is one member of a multigene family.",
"Human serum paraoxonase (PON1) isozymes Q and R hydrolyze lactones and cyclic carbonate esters."
] | [
1996,
2000
] | 2 | [
"IPR002640"
] | [] | 1 | 0 | 1 | [
"Tetrapoda"
] | [
508
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
8,
2,
6
] | 3 | true | Family | Paraoxonase2 | Paraoxonase2 | Paraoxonase2 | 2 |
IPR008365 | 8,365 | Prostanoid receptor | Prostanoid_rcpt | Family | 9,000 | false | false | G protein-coupled receptors (GPCRs) constitute a vast protein family that encompasses a wide range of functions, including various autocrine, paracrine and endocrine processes. They show considerable diversity at the sequence level, on the basis of which they can be separated into distinct groups [ ]. The term clan can... | [
"GO:0007186",
"GO:0016020"
] | [
"G protein-coupled receptor signaling pathway",
"membrane"
] | [
"biological_process",
"cellular_component"
] | 2 | [
"PRINTS",
"PANTHER"
] | [
"PR01788",
"PTHR11866"
] | [
"PROSTANOIDR",
""
] | [
8010,
8681
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-391908",
"R-BTA-416476",
"R-BTA-416482",
"R-BTA-418594",
"R-BTA-428930",
"R-CFA-391908",
"R-CFA-416476",
"R-HSA-391908",
"R-HSA-392851",
"R-HSA-416476",
"R-HSA-416482",
"R-HSA-418555",
"R-HSA-418594",
"R-HSA-428930",
"R-MMU-391908",
"R-MMU-392851",
"R-MMU-416476",
"R-MMU-416... | [
"REACTOME:R-BTA-391908",
"REACTOME:R-BTA-416476",
"REACTOME:R-BTA-416482",
"REACTOME:R-BTA-418594",
"REACTOME:R-BTA-428930",
"REACTOME:R-CFA-391908",
"REACTOME:R-CFA-416476",
"REACTOME:R-HSA-391908",
"REACTOME:R-HSA-392851",
"REACTOME:R-HSA-416476",
"REACTOME:R-HSA-416482",
"REACTOME:R-HSA-418... | 29 | [
"5yhl",
"5ywy",
"6ak3",
"6iiu",
"6iiv",
"6m9t",
"7cx2",
"7cx3",
"7cx4",
"7d7m",
"7wu9",
"8gcm",
"8gcp",
"8gd9",
"8gda",
"8gdb",
"8gdc",
"8iq4",
"8iq6",
"8iuk",
"8iul",
"8ium",
"8x79",
"8x7a",
"8xjk",
"8xjl",
"8xjm",
"8xjn",
"8xjo",
"8zvz",
"8zw0",
"9au0"... | 44 | [
"PUB00000131",
"PUB00002477",
"PUB00004960",
"PUB00004961",
"PUB00053635",
"PUB00063577",
"PUB00063578",
"PUB00063579",
"PUB00063580",
"PUB00063816"
] | [
"2111655",
"2830256",
"8386361",
"8170923",
"12679517",
"8081729",
"15914470",
"18948278",
"16753280",
"23020293"
] | [
"G proteins in signal transduction.",
"G protein involvement in receptor-effector coupling.",
"Design of a discriminating fingerprint for G-protein-coupled receptors.",
"Fingerprinting G-protein-coupled receptors.",
"The G protein-coupled receptor repertoires of human and mouse.",
"GCRDb: a G-protein-coup... | [
1990,
1988,
1993,
1994,
2003,
1994,
2005,
2009,
2006,
2013
] | 10 | [
"IPR000276"
] | [
"IPR000141",
"IPR000370",
"IPR000376",
"IPR001105",
"IPR001244",
"IPR001923"
] | 1 | 6 | 0 | [
"Eukaryota"
] | [
9000
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
26,
2,
31,
27,
37
] | 5 | true | Family | Prostanoid receptor | Prostanoid receptor | Prostanoid_rcpt | 2 |
IPR008366 | 8,366 | Nuclear factor of activated T cells (NFAT) | NFAT | Family | 8,806 | false | false | Antigenic stimulation of T lymphocytes initiates a complex series of intracellular signal transduction pathways that leads to the expression of a panel of immunoregulatory genes, whose function is critical to the initiation and coordination of the immune response. The multi-subunit nuclear factor of activated T cells (... | [
"GO:0003700",
"GO:0006355"
] | [
"DNA-binding transcription factor activity",
"regulation of DNA-templated transcription"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PRINTS",
"PANTHER"
] | [
"PR01789",
"PTHR12533"
] | [
"NUCFACTORATC",
""
] | [
7316,
8798
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-2025928",
"R-HSA-2871809",
"R-HSA-4086398",
"R-HSA-5607763",
"R-HSA-8877330",
"R-MMU-2025928",
"R-MMU-2871809",
"R-MMU-4086398",
"R-MMU-5607763",
"R-RNO-2025928",
"R-RNO-2871809",
"R-RNO-5607763"
] | [
"REACTOME:R-HSA-2025928",
"REACTOME:R-HSA-2871809",
"REACTOME:R-HSA-4086398",
"REACTOME:R-HSA-5607763",
"REACTOME:R-HSA-8877330",
"REACTOME:R-MMU-2025928",
"REACTOME:R-MMU-2871809",
"REACTOME:R-MMU-4086398",
"REACTOME:R-MMU-5607763",
"REACTOME:R-RNO-2025928",
"REACTOME:R-RNO-2871809",
"REACTOM... | 12 | [
"1a02",
"1a66",
"1imh",
"1nfa",
"1owr",
"1p7h",
"1pzu",
"1s9k",
"2as5",
"2o93",
"2yrp",
"3qrf",
"8ow4",
"8r07",
"8r3f"
] | 15 | [
"PUB00011687"
] | [
"10652349"
] | [
"Identification of amino acid residues and protein kinases involved in the regulation of NFATc subcellular localization."
] | [
2000
] | 1 | [] | [] | 0 | 0 | null | [
"Metazoa"
] | [
8806
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
37,
8,
34,
48,
29
] | 5 | true | Family | Nuclear factor of activated T cells (NFAT) | Nuclear factor of activated T cells (NFAT) | NFAT | 9 |
IPR008367 | 8,367 | Regucalcin | Regucalcin | Family | 2,543 | false | false | Regucalcin, also known as senesence marker protein-30 (SMP30), was discovered in 1978 as a Ca 2+ binding protein that does not contain EF-hand motifs, suggesting a novel class of Ca 2+ binding protein. It is primarily localised to the liver and kidney cortex of animals. Expression of its mRNA in the liver and renal cor... | [
"GO:0005509",
"GO:0030234"
] | [
"calcium ion binding",
"enzyme regulator activity"
] | [
"molecular_function",
"molecular_function"
] | 2 | [
"PRINTS"
] | [
"PR01791"
] | [
"REGUCALCIN"
] | [
2543
] | 1 | [
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC"
] | [
"3.1.1.17",
"PWY-2221",
"PWY-5530",
"PWY-7165",
"PWY-8142"
] | [
"EC:3.1.1.17",
"METACYC:PWY-2221",
"METACYC:PWY-5530",
"METACYC:PWY-7165",
"METACYC:PWY-8142"
] | 5 | [
"3g4e",
"3g4h",
"4gn7",
"4gn8",
"4gn9",
"4gna",
"4gnb",
"4gnc"
] | 8 | [
"PUB00011463",
"PUB00011526",
"PUB00011527",
"PUB00018983",
"PUB00018984",
"PUB00018985",
"PUB00018986"
] | [
"1315924",
"8232287",
"9278268",
"8348951",
"1618342",
"2177680",
"9586564"
] | [
"Reversible effect of calcium-binding protein regucalcin on the Ca(2+)-induced inhibition of deoxyuridine 5'-triphosphatase activity in rat liver cytosol.",
"Regulatory effect of regucalcin on (Ca(2+)-Mg2+)-ATPase in rat liver plasma membranes: comparison with the activation by Mn2+ and Co2+.",
"Inhibitory effe... | [
1992,
1993,
1997,
1993,
1992,
1990,
1998
] | 7 | [
"IPR005511"
] | [] | 1 | 0 | 1 | [
"Bacteria",
"Eukaryota",
"Halobacteriales",
"ecological metagenomes"
] | [
359,
2163,
7,
14
] | 4 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
2,
1,
3
] | 4 | true | Family | Regucalcin | Regucalcin | Regucalcin | 9 |
IPR008368 | 8,368 | Voltage-dependent calcium channel, gamma subunit | VDCC_gsu | Family | 6,391 | false | false | Ca2+ ions are unique in that they not only carry charge but they are also the most widely used of diffusible second messengers. Voltage-dependent Ca2+ channels (VDCC) are a family of molecules that allow cells to couple electrical activity to intracellular Ca2+ signalling. The opening and closing of these channels by d... | [
"GO:0006816",
"GO:0016020"
] | [
"calcium ion transport",
"membrane"
] | [
"biological_process",
"cellular_component"
] | 2 | [
"PRINTS"
] | [
"PR01792"
] | [
"VDCCGAMMA"
] | [
6391
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-399719",
"R-BTA-5682910",
"R-HSA-112308",
"R-HSA-399719",
"R-HSA-5576892",
"R-HSA-5576893",
"R-HSA-5682910",
"R-HSA-9856532",
"R-MMU-112308",
"R-MMU-399719",
"R-MMU-5576892",
"R-MMU-5576893",
"R-MMU-5682910",
"R-RNO-112308",
"R-RNO-399719",
"R-RNO-5576892",
"R-RNO-5576893",
... | [
"REACTOME:R-BTA-399719",
"REACTOME:R-BTA-5682910",
"REACTOME:R-HSA-112308",
"REACTOME:R-HSA-399719",
"REACTOME:R-HSA-5576892",
"REACTOME:R-HSA-5576893",
"REACTOME:R-HSA-5682910",
"REACTOME:R-HSA-9856532",
"REACTOME:R-MMU-112308",
"REACTOME:R-MMU-399719",
"REACTOME:R-MMU-5576892",
"REACTOME:R-M... | 18 | [
"3jbr",
"5gjv",
"5gjw",
"5kbs",
"5kbt",
"5kbu",
"5kk2",
"5vot",
"5vou",
"5vov",
"5weo",
"6dlz",
"6dm0",
"6dm1",
"6jp5",
"6jp8",
"6jpa",
"6jpb",
"6njl",
"6njm",
"6njn",
"6o9g",
"6qkc",
"6qkz",
"7jpk",
"7jpl",
"7jpv",
"7jpw",
"7jpx",
"7ldd",
"7lde",
"7lep"... | 127 | [
"PUB00007806",
"PUB00036034"
] | [
"11170751",
"14657414"
] | [
"A cluster of three novel Ca2+ channel gamma subunit genes on chromosome 19q13.4: evolution and expression profile of the gamma subunit gene family.",
"International Union of Pharmacology. XL. Compendium of voltage-gated ion channels: calcium channels."
] | [
2001,
2003
] | 2 | [
"IPR004031"
] | [
"IPR005421",
"IPR005422",
"IPR005423",
"IPR008369",
"IPR008370",
"IPR008371",
"IPR008372"
] | 1 | 7 | 0 | [
"Bilateria"
] | [
6391
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
23,
14,
23,
20
] | 4 | true | Family | Voltage-dependent calcium channel, gamma subunit | Voltage-dependent calcium channel, gamma subunit | VDCC_gsu | 1 |
IPR008369 | 8,369 | Voltage-dependent calcium channel, gamma-5 subunit | VDCC_g5su | Family | 959 | false | false | Ca2+ ions are unique in that they not only carry charge but they are also the most widely used of diffusible second messengers. Voltage-dependent Ca2+ channels (VDCC) are a family of molecules that allow cells to couple electrical activity to intracellular Ca2+ signalling. The opening and closing of these channels by d... | [
"GO:0006816",
"GO:0016020"
] | [
"calcium ion transport",
"membrane"
] | [
"biological_process",
"cellular_component"
] | 2 | [
"PRINTS"
] | [
"PR01793"
] | [
"VDCCGAMMA5"
] | [
959
] | 1 | [] | [] | [] | 0 | [
"7ryy",
"7rz4",
"7rz5",
"7rz6",
"7rz7",
"7rz8",
"8ss2",
"8ss3",
"8ss4",
"8ss5",
"8ss6",
"8ss7",
"8ss8",
"8ss9",
"8ssa",
"8ssb"
] | 16 | [
"PUB00007806",
"PUB00036034"
] | [
"11170751",
"14657414"
] | [
"A cluster of three novel Ca2+ channel gamma subunit genes on chromosome 19q13.4: evolution and expression profile of the gamma subunit gene family.",
"International Union of Pharmacology. XL. Compendium of voltage-gated ion channels: calcium channels."
] | [
2001,
2003
] | 2 | [
"IPR008368"
] | [] | 1 | 0 | 1 | [
"Gnathostomata"
] | [
959
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
2,
3,
2
] | 4 | true | Family | Voltage-dependent calcium channel, gamma-5 subunit | Voltage-dependent calcium channel, gamma-5 subunit | VDCC_g5su | 7 |
IPR008370 | 8,370 | Voltage-dependent calcium channel, gamma-6 subunit | VDCC_g6su | Family | 398 | false | false | Ca2+ ions are unique in that they not only carry charge but they are also the most widely used of diffusible second messengers. Voltage-dependent Ca2+ channels (VDCC) are a family of molecules that allow cells to couple electrical activity to intracellular Ca2+ signalling. The opening and closing of these channels by d... | [
"GO:0006816",
"GO:0016020"
] | [
"calcium ion transport",
"membrane"
] | [
"biological_process",
"cellular_component"
] | 2 | [
"PRINTS"
] | [
"PR01794"
] | [
"VDCCGAMMA6"
] | [
398
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-5576892",
"R-HSA-5576893",
"R-MMU-5576892",
"R-MMU-5576893",
"R-RNO-5576892",
"R-RNO-5576893"
] | [
"REACTOME:R-HSA-5576892",
"REACTOME:R-HSA-5576893",
"REACTOME:R-MMU-5576892",
"REACTOME:R-MMU-5576893",
"REACTOME:R-RNO-5576892",
"REACTOME:R-RNO-5576893"
] | 6 | [] | 0 | [
"PUB00007806",
"PUB00036034"
] | [
"11170751",
"14657414"
] | [
"A cluster of three novel Ca2+ channel gamma subunit genes on chromosome 19q13.4: evolution and expression profile of the gamma subunit gene family.",
"International Union of Pharmacology. XL. Compendium of voltage-gated ion channels: calcium channels."
] | [
2001,
2003
] | 2 | [
"IPR008368"
] | [] | 1 | 0 | 1 | [
"Euteleostomi"
] | [
398
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
4,
3
] | 3 | true | Family | Voltage-dependent calcium channel, gamma-6 subunit | Voltage-dependent calcium channel, gamma-6 subunit | VDCC_g6su | 2 |
IPR008371 | 8,371 | Voltage-dependent calcium channel, gamma-7 subunit | VDCC_g7su | Family | 654 | false | false | Ca2+ ions are unique in that they not only carry charge but they are also the most widely used of diffusible second messengers. Voltage-dependent Ca2+ channels (VDCC) are a family of molecules that allow cells to couple electrical activity to intracellular Ca2+ signalling. The opening and closing of these channels by d... | [
"GO:0006816",
"GO:0016020"
] | [
"calcium ion transport",
"membrane"
] | [
"biological_process",
"cellular_component"
] | 2 | [
"PRINTS"
] | [
"PR01795"
] | [
"VDCCGAMMA7"
] | [
654
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-5576892",
"R-HSA-5576893",
"R-HSA-9856532",
"R-MMU-5576892",
"R-MMU-5576893",
"R-RNO-5576892",
"R-RNO-5576893"
] | [
"REACTOME:R-HSA-5576892",
"REACTOME:R-HSA-5576893",
"REACTOME:R-HSA-9856532",
"REACTOME:R-MMU-5576892",
"REACTOME:R-MMU-5576893",
"REACTOME:R-RNO-5576892",
"REACTOME:R-RNO-5576893"
] | 7 | [] | 0 | [
"PUB00007806",
"PUB00036034"
] | [
"11170751",
"14657414"
] | [
"A cluster of three novel Ca2+ channel gamma subunit genes on chromosome 19q13.4: evolution and expression profile of the gamma subunit gene family.",
"International Union of Pharmacology. XL. Compendium of voltage-gated ion channels: calcium channels."
] | [
2001,
2003
] | 2 | [
"IPR008368"
] | [] | 1 | 0 | 1 | [
"Euteleostomi"
] | [
654
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
4,
2,
3,
2
] | 4 | true | Family | Voltage-dependent calcium channel, gamma-7 subunit | Voltage-dependent calcium channel, gamma-7 subunit | VDCC_g7su | 2 |
IPR008372 | 8,372 | Voltage-dependent calcium channel, gamma-8 subunit | VDCC_g8su | Family | 201 | false | false | Ca2+ ions are unique in that they not only carry charge but they are also the most widely used of diffusible second messengers. Voltage-dependent Ca2+ channels (VDCC) are a family of molecules that allow cells to couple electrical activity to intracellular Ca2+ signalling. The opening and closing of these channels by d... | [
"GO:0006816",
"GO:0016020"
] | [
"calcium ion transport",
"membrane"
] | [
"biological_process",
"cellular_component"
] | 2 | [
"PRINTS"
] | [
"PR01796"
] | [
"VDCCGAMMA8"
] | [
201
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-399719",
"R-HSA-5576892",
"R-HSA-5576893",
"R-HSA-5682910",
"R-MMU-399719",
"R-MMU-5576892",
"R-MMU-5576893",
"R-MMU-5682910",
"R-RNO-399719",
"R-RNO-5576892",
"R-RNO-5576893",
"R-RNO-5682910"
] | [
"REACTOME:R-HSA-399719",
"REACTOME:R-HSA-5576892",
"REACTOME:R-HSA-5576893",
"REACTOME:R-HSA-5682910",
"REACTOME:R-MMU-399719",
"REACTOME:R-MMU-5576892",
"REACTOME:R-MMU-5576893",
"REACTOME:R-MMU-5682910",
"REACTOME:R-RNO-399719",
"REACTOME:R-RNO-5576892",
"REACTOME:R-RNO-5576893",
"REACTOME:R... | 12 | [
"6qkc",
"6qkz",
"7ldd",
"7lde",
"7lep",
"7oca",
"7ocd",
"7oce",
"7ocf",
"7qhb",
"7qhh",
"8ayl",
"8aym",
"8ayn",
"8ayo"
] | 15 | [
"PUB00007806",
"PUB00036034"
] | [
"11170751",
"14657414"
] | [
"A cluster of three novel Ca2+ channel gamma subunit genes on chromosome 19q13.4: evolution and expression profile of the gamma subunit gene family.",
"International Union of Pharmacology. XL. Compendium of voltage-gated ion channels: calcium channels."
] | [
2001,
2003
] | 2 | [
"IPR008368"
] | [] | 1 | 0 | 1 | [
"Euteleostomi"
] | [
201
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
2,
2
] | 3 | true | Family | Voltage-dependent calcium channel, gamma-8 subunit | Voltage-dependent calcium channel, gamma-8 subunit | VDCC_g8su | 4 |
IPR008373 | 8,373 | Saposin | Saposin | Family | 4,319 | false | false | Sphingolipids are bioactive compounds found in lower and higher eukaryotes. They are involved in the regulation of various cellular functions, such as growth, differentiation and apoptosis, and are believed to be essential in a healthy diet. Sphigolipids are degraded in the lysosome, and the products from their hydroly... | [
"GO:0006665",
"GO:0005764"
] | [
"sphingolipid metabolic process",
"lysosome"
] | [
"biological_process",
"cellular_component"
] | 2 | [
"PRINTS"
] | [
"PR01797"
] | [
"SAPOSIN"
] | [
4319
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-5683826",
"R-HSA-114608",
"R-HSA-375276",
"R-HSA-418594",
"R-HSA-5683826",
"R-HSA-5688031",
"R-HSA-5688849",
"R-HSA-5688890",
"R-HSA-6798695",
"R-HSA-9840310",
"R-MMU-114608",
"R-MMU-375276",
"R-MMU-418594",
"R-MMU-5683826",
"R-MMU-6798695",
"R-MMU-9840310",
"R-RNO-114608",
... | [
"REACTOME:R-BTA-5683826",
"REACTOME:R-HSA-114608",
"REACTOME:R-HSA-375276",
"REACTOME:R-HSA-418594",
"REACTOME:R-HSA-5683826",
"REACTOME:R-HSA-5688031",
"REACTOME:R-HSA-5688849",
"REACTOME:R-HSA-5688890",
"REACTOME:R-HSA-6798695",
"REACTOME:R-HSA-9840310",
"REACTOME:R-MMU-114608",
"REACTOME:R-... | 22 | [
"1m12",
"1n69",
"1sn6",
"2dob",
"2gtg",
"2qyp",
"2r0r",
"2r1q",
"2rb3",
"2z9a",
"3bqp",
"3bqq",
"3rfi",
"4ddj",
"4uex",
"4v2o",
"5nxb",
"5u85",
"6slr",
"7p4t",
"8equ",
"9avs",
"9axg",
"9i63"
] | 24 | [
"PUB00011688",
"PUB00011689"
] | [
"2515150",
"2019586"
] | [
"Molecular cloning of a human co-beta-glucosidase cDNA: evidence that four sphingolipid hydrolase activator proteins are encoded by single genes in humans and rats.",
"Sulfatide activator protein. Alternative splicing that generates three mRNAs and a newly found mutation responsible for a clinical disease."
] | [
1989,
1991
] | 2 | [] | [
"IPR021165"
] | 0 | 1 | 0 | [
"Eukaryota",
"Kangiella spongicola"
] | [
4318,
1
] | 2 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
1,
1,
5,
4,
12,
28,
4,
18,
2
] | 9 | true | Family | Saposin | Saposin | Saposin | 9 |
IPR008374 | 8,374 | SF-assemblin/beta-giardin | SF_assemblin/giardin_b | Family | 2,145 | false | false | Striated fibre assemblin (SFA), an acidic 33kDa protein, is the major component of striated microtubule-associated fibres (SMAFs) in the flagellar basal apparatus of green flagellates. In Chlamydomonas, and other green flagellates, the SMAFs form a cross-like pattern and run alongside the proximal parts of four bundles... | [
"GO:0005200"
] | [
"structural constituent of cytoskeleton"
] | [
"molecular_function"
] | 1 | [
"PFAM",
"PRINTS",
"PANTHER"
] | [
"PF06705",
"PR01799",
"PTHR40412"
] | [
"SF-assemblin",
"SFASSEMBLIN",
""
] | [
2048,
467,
603
] | 3 | [] | [] | [] | 0 | [] | 0 | [
"PUB00011691",
"PUB00088847"
] | [
"8491776",
"19214572"
] | [
"SF-assemblin, the structural protein of the 2-nm filaments from striated microtubule associated fibers of algal flagellar roots, forms a segmented coiled coil.",
"Changes in beta-giardin sequence of Giardia intestinalis sensitive and resistant to albendazole strains."
] | [
1993,
2009
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota"
] | [
3,
2142
] | 2 | [] | [] | 0 | true | Family | SF-assemblin/beta-giardin | SF-assemblin/beta-giardin | SF_assemblin/giardin_b | 9 |
IPR008375 | 8,375 | Staphylococcus aureus exotoxin | Staph_exotoxin | Family | 447 | false | false | Staphylococcus aureus is a well-characterised and specialised prokaryotic human pathogen, expressing a variety of virulence factors to enable successful infection of the host. Symptoms usually manifest in cases of food poisoning, pyrogenic fever and toxic shock syndrome, and can prove lethal in immunocompromised patien... | [] | [] | [] | 0 | [
"PRINTS"
] | [
"PR01800"
] | [
"STAPHEXOTOXN"
] | [
447
] | 1 | [] | [] | [] | 0 | [
"1m4v",
"1ts2",
"1ts4",
"1ts5",
"1v1o",
"1v1p",
"2ij0",
"2qej",
"2qil",
"2r61",
"2rdg",
"2rdh",
"2tss",
"2z8l",
"3kls",
"3km9",
"3mfg",
"3o13",
"3prx",
"3r2i",
"3r2t",
"3tss",
"3ury",
"3v05",
"4dxf",
"4dxg",
"4o1n",
"4rco",
"4rfb",
"4rgt",
"4rh6",
"4tss"... | 42 | [
"PUB00011690"
] | [
"10899837"
] | [
"Identification of a novel gene cluster encoding staphylococcal exotoxin-like proteins: characterization of the prototypic gene and its protein product, SET1."
] | [
2000
] | 1 | [
"IPR013307"
] | [] | 1 | 0 | 1 | [
"Bacteria"
] | [
447
] | 1 | [] | [] | 0 | true | Family | Staphylococcus aureus exotoxin | Staphylococcus aureus exotoxin | Staph_exotoxin | 7 |
IPR008376 | 8,376 | Chaperone Ric-8 A/B | Chaperone_Ric-8_A/B | Domain | 3,345 | false | false | The chaperones Ric-8, also known as Synembryns, specifically bind and fold nascent G alpha proteins prior to G protein heterotrimer formation, promoting their stability and activity. Mammalian Chaperone Ric-8A assists the folding of GNAI1, GNAO1, GNA13 and GNAQ but doesn't fold Gα proteins GNAS nor GNAL [ ]. It also ac... | [] | [] | [] | 0 | [
"PRINTS"
] | [
"PR01802"
] | [
"SYNEMBRYN"
] | [
3345
] | 1 | [] | [] | [] | 0 | [
"6n85",
"6n86",
"6nmg",
"6nmj",
"6tyl",
"6ukt",
"6vu5",
"6vu8",
"8el7",
"8el8"
] | 10 | [
"PUB00011692",
"PUB00011693",
"PUB00018998",
"PUB00155427",
"PUB00155473",
"PUB00155474",
"PUB00155475",
"PUB00155476",
"PUB00155477"
] | [
"10985349",
"11102364",
"12509430",
"22114146",
"16275912",
"29844055",
"31155309",
"32103024",
"36931277"
] | [
"RIC-8 (Synembryn): a novel conserved protein that is required for G(q)alpha signaling in the C. elegans nervous system.",
"A role for RIC-8 (Synembryn) and GOA-1 (G(o)alpha) in regulating a subset of centrosome movements during early embryogenesis in Caenorhabditis elegans.",
"Mammalian Ric-8A (synembryn) is a... | [
2000,
2000,
2003,
2011,
2005,
2018,
2019,
2020,
2023
] | 9 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
3345
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
19,
2,
7,
4,
11
] | 6 | true | Domain | Chaperone Ric-8 A/B | Chaperone Ric-8 A/B | Chaperone_Ric-8_A/B | 5 |
IPR008377 | 8,377 | Trypanosome sialidase | Sialidase_trypan | Family | 4,564 | false | false | Trypanosoma cruzi is a kinetoplastid protozoan parasite of humans and other animals, the causative agent of Chagas disease. It is transmitted via an insect vector, and exists as an intracellular form, the amastigote, or as a trypomastigote form in the blood after infection. In the human host, chronic infection by T. cr... | [
"GO:0004308"
] | [
"exo-alpha-sialidase activity"
] | [
"molecular_function"
] | 1 | [
"PRINTS"
] | [
"PR01803"
] | [
"TCSIALIDASE"
] | [
4564
] | 1 | [
"EC"
] | [
"3.2.1.18"
] | [
"EC:3.2.1.18"
] | 1 | [
"1dil",
"1dim",
"1mr5",
"1ms0",
"1ms1",
"1ms3",
"1ms4",
"1ms5",
"1ms8",
"1ms9",
"1mz5",
"1mz6",
"1n1s",
"1n1t",
"1n1v",
"1n1y",
"1s0i",
"1s0j",
"1wcs",
"2a75",
"2ags",
"2ah2",
"2fhr",
"2sil",
"2sim",
"3b69",
"3opz",
"3pjq",
"3sil",
"4bbw",
"4fj6",
"4q6k"... | 42 | [
"PUB00011694",
"PUB00011695"
] | [
"2034687",
"1695668"
] | [
"The major 85-kDa surface antigen of the mammalian-stage forms of Trypanosoma cruzi is a family of sialidases.",
"The major 85-kD surface antigen of the mammalian form of Trypanosoma cruzi is encoded by a large heterogeneous family of simultaneously expressed genes."
] | [
1991,
1990
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Candidatus Iainarchaeum sp.",
"Trypanosoma",
"unclassified sequences"
] | [
428,
1,
4129,
6
] | 4 | [] | [] | 0 | true | Family | Trypanosome sialidase | Trypanosome sialidase | Sialidase_trypan | 1 |
IPR008379 | 8,379 | Band 4.1, C-terminal | Band_4.1_C | Domain | 13,576 | false | false | There is a unique sequence domain at the C terminus of all known 4.1 proteins, known as the C-terminal domain (CTD). Mammalian CTDs are associated with a growing number of protein-protein interactions, although such activities have yet to be associated with invertebrate CTDs. Mammalian CTDs are generally defined by seq... | [
"GO:0003779",
"GO:0005198",
"GO:0005856"
] | [
"actin binding",
"structural molecule activity",
"cytoskeleton"
] | [
"molecular_function",
"molecular_function",
"cellular_component"
] | 3 | [
"PFAM"
] | [
"PF05902"
] | [
"4_1_CTD"
] | [
13576
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-6794361",
"R-DME-6794361",
"R-HSA-399719",
"R-HSA-6794361",
"R-HSA-9662360",
"R-HSA-9662361",
"R-MMU-399719",
"R-MMU-6794361",
"R-RNO-399719",
"R-RNO-6794361"
] | [
"REACTOME:R-BTA-6794361",
"REACTOME:R-DME-6794361",
"REACTOME:R-HSA-399719",
"REACTOME:R-HSA-6794361",
"REACTOME:R-HSA-9662360",
"REACTOME:R-HSA-9662361",
"REACTOME:R-MMU-399719",
"REACTOME:R-MMU-6794361",
"REACTOME:R-RNO-399719",
"REACTOME:R-RNO-6794361"
] | 10 | [
"8i8y"
] | 1 | [
"PUB00011236"
] | [
"11432737"
] | [
"Properties of the C-terminal domain of 4.1 proteins."
] | [
2001
] | 1 | [] | [] | 0 | 0 | null | [
"Eumetazoa"
] | [
13576
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
4,
182,
4,
44,
51,
44
] | 6 | true | Domain | Band 4.1, C-terminal | Band 4.1, C-terminal | Band_4.1_C | 5 |
IPR008380 | 8,380 | HAD-superfamily hydrolase, subfamily IG, 5'-nucleotidase | HAD-SF_hydro_IG_5-nucl | Family | 13,995 | false | false | This family includes a 5'-nucleotidase, , specific for purines (IMP and GMP) [ ]. These enzymes are members of the Haloacid Dehalogenase (HAD) superfamily. HAD members are recognised by three short motifs {hhhhDxDx(T/V)}, {hhhh(T/S)}, and either {hhhh(D/E)(D/E)x(3-4)(G/N)} or {hhhh(G/N)(D/E)x(3-4)(D/E)} (where "h" stan... | [] | [] | [] | 0 | [
"PFAM",
"PANTHER",
"NCBIFAM"
] | [
"PF05761",
"PTHR12103",
"TIGR02244"
] | [
"5_nucleotid",
"",
"HAD-IG-Ncltidse"
] | [
13988,
13733,
10559
] | 3 | [
"EC",
"GP",
"GP",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"3.1.3",
"GenProp1469",
"GenProp1753",
"R-BTA-2161541",
"R-BTA-74259",
"R-BTA-9755088",
"R-DDI-2161541",
"R-DDI-74259",
"R-DDI-9755088",
"R-GGA-421178",
"R-HSA-2161541",
"R-HSA-74259",
"R-HSA-9755088",
"R-MMU-2161541",
"R-MMU-74259",
"R-MMU-9755088",
"R-RNO-2161541",
"R-RNO-74259",... | [
"EC:3.1.3",
"GP:GenProp1469",
"GP:GenProp1753",
"REACTOME:R-BTA-2161541",
"REACTOME:R-BTA-74259",
"REACTOME:R-BTA-9755088",
"REACTOME:R-DDI-2161541",
"REACTOME:R-DDI-74259",
"REACTOME:R-DDI-9755088",
"REACTOME:R-GGA-421178",
"REACTOME:R-HSA-2161541",
"REACTOME:R-HSA-74259",
"REACTOME:R-HSA-9... | 22 | [
"2bde",
"2j2c",
"2jc9",
"2jcm",
"2xcv",
"2xcw",
"2xcx",
"2xjb",
"2xjc",
"2xjd",
"2xje",
"2xjf",
"4g63",
"4h4b",
"4ohf",
"5cqz",
"5cr7",
"5k7y",
"5l4z",
"5l50",
"5opk",
"5opl",
"5opm",
"5opn",
"5opo",
"5opp",
"6dd3",
"6ddb",
"6ddc",
"6ddh",
"6ddk",
"6ddl"... | 46 | [
"PUB00015569"
] | [
"9371705"
] | [
"Bovine cytosolic IMP/GMP-specific 5'-nucleotidase: cloning and expression of active enzyme in Escherichia coli."
] | [
1997
] | 1 | [] | [
"IPR016695"
] | 0 | 1 | 0 | [
"Bacteria",
"Eukaryota",
"hydrothermal vent metagenome"
] | [
322,
13671,
2
] | 3 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
21,
3,
18,
13,
26,
22,
17,
21,
54
] | 9 | true | Family | HAD-superfamily hydrolase, subfamily IG, 5'-nucleotidase | HAD-superfamily hydrolase, subfamily IG, 5'-nucleotidase | HAD-SF_hydro_IG_5-nucl | 9 |
IPR008381 | 8,381 | Succinate dehydrogenase assembly factor 3, mitochondrial | SDHAF3/Sdh7 | Family | 2,988 | false | false | Succinate dehydrogenase assembly factor 3 (SDHAF3, also known as Sdh7 in budding yeasts) is a mitochondrial protein involved in assembly of succinate dehydrogenase. It is a member of the LYR protein family [ ]. | [
"GO:0034553",
"GO:0005739"
] | [
"mitochondrial respiratory chain complex II assembly",
"mitochondrion"
] | [
"biological_process",
"cellular_component"
] | 2 | [
"PANTHER"
] | [
"PTHR13137"
] | [
""
] | [
2988
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-9854311",
"R-HSA-9854311",
"R-MMU-9854311"
] | [
"REACTOME:R-BTA-9854311",
"REACTOME:R-HSA-9854311",
"REACTOME:R-MMU-9854311"
] | 3 | [] | 0 | [
"PUB00089688"
] | [
"24954417"
] | [
"The LYR factors SDHAF1 and SDHAF3 mediate maturation of the iron-sulfur subunit of succinate dehydrogenase."
] | [
2014
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
2988
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strai... | [
2,
2,
2,
2,
3,
1,
4,
1,
1
] | 9 | true | Family | Succinate dehydrogenase assembly factor 3, mitochondrial | Succinate dehydrogenase assembly factor 3, mitochondrial | SDHAF3/Sdh7 | 9 |
IPR008382 | 8,382 | SPHK1-interactor/A-kinase anchor 110kDa | SPHK1-interactor_AKAP_110 | Family | 3,517 | false | false | This family consists of several mammalian protein kinase A anchoring protein 3 (PRKA3) or A-kinase anchor protein 110kDa (AKAP 110) sequences. Agents that increase intracellular cAMP are potent stimulators of sperm motility. Anchoring inhibitor peptides, designed to disrupt the interaction of the cAMP-dependent protein... | [] | [] | [] | 0 | [
"PANTHER"
] | [
"PTHR10226"
] | [
""
] | [
3517
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00011239",
"PUB00052585"
] | [
"10319321",
"12080051"
] | [
"Isolation and molecular characterization of AKAP110, a novel, sperm-specific protein kinase A-anchoring protein.",
"Cloning and characterization of a protein kinase A anchoring protein (AKAP)-related protein that interacts with and regulates sphingosine kinase 1 activity."
] | [
1999,
2002
] | 2 | [] | [
"IPR020799"
] | 0 | 1 | 0 | [
"Vertebrata"
] | [
3517
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
13,
13,
12,
25
] | 4 | true | Family | SPHK1-interactor/A-kinase anchor 110kDa | SPHK1-interactor/A-kinase anchor 110kDa | SPHK1-interactor_AKAP_110 | 2 |
IPR008383 | 8,383 | Apoptosis inhibitory 5 | API5 | Family | 3,503 | false | false | This family consists of apoptosis inhibitory protein 5 (API5) sequences from several organisms. Apoptosis or programmed cell death is a physiological form of cell death that occurs in embryonic development and organ formation. It is characterised by biochemical and morphological changes such as DNA fragmentation and ce... | [] | [] | [] | 0 | [
"PFAM",
"PANTHER"
] | [
"PF05918",
"PTHR12758"
] | [
"API5",
""
] | [
3499,
3374
] | 2 | [] | [] | [] | 0 | [
"3u0r",
"3v6a",
"6l4o"
] | 3 | [
"PUB00011538",
"PUB00011539",
"PUB00098158"
] | [
"10393420",
"9307294",
"22334682"
] | [
"Molecular cloning and fine mapping of API5L1, a novel human gene strongly related to an antiapoptotic gene.",
"AAC-11, a novel cDNA that inhibits apoptosis after growth factor withdrawal.",
"Helical repeat structure of apoptosis inhibitor 5 reveals protein-protein interaction modules."
] | [
1999,
1997,
2012
] | 3 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Halocatena marina"
] | [
3502,
1
] | 2 | [
"Arabidopsis thaliana",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
31,
2,
1,
4,
2,
1,
4,
18
] | 8 | true | Family | Apoptosis inhibitory 5 | Apoptosis inhibitory 5 | API5 | 4 |
IPR008384 | 8,384 | Actin-related protein 2/3 complex subunit 4 | ARPC4 | Family | 5,542 | false | false | Arp2/3 binds to pre-existing actin filaments and nucleates new daughter filaments, and thus becomes incorporated into the dynamic actin network at the leading edge of motile cells and other actin-based protrusive structures [ ]. In order to nucleate filaments, Arp2/3 must bind to a member of the N-WASp/SCAR family prot... | [
"GO:0030041",
"GO:0034314",
"GO:0005885",
"GO:0015629"
] | [
"actin filament polymerization",
"Arp2/3 complex-mediated actin nucleation",
"Arp2/3 protein complex",
"actin cytoskeleton"
] | [
"biological_process",
"biological_process",
"cellular_component",
"cellular_component"
] | 4 | [
"PFAM",
"PIRSF",
"PANTHER"
] | [
"PF05856",
"PIRSF039100",
"PTHR22629"
] | [
"ARPC4",
"ARPC4",
""
] | [
5542,
4292,
5415
] | 3 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-2029482",
"R-BTA-3928662",
"R-BTA-5663213",
"R-BTA-8856828",
"R-CEL-2029482",
"R-CEL-3928662",
"R-CEL-5663213",
"R-CEL-8856828",
"R-DDI-2029482",
"R-DDI-5663213",
"R-HSA-2029482",
"R-HSA-3928662",
"R-HSA-5663213",
"R-HSA-8856828",
"R-HSA-9664422",
"R-MMU-2029482",
"R-MMU-39286... | [
"REACTOME:R-BTA-2029482",
"REACTOME:R-BTA-3928662",
"REACTOME:R-BTA-5663213",
"REACTOME:R-BTA-8856828",
"REACTOME:R-CEL-2029482",
"REACTOME:R-CEL-3928662",
"REACTOME:R-CEL-5663213",
"REACTOME:R-CEL-8856828",
"REACTOME:R-DDI-2029482",
"REACTOME:R-DDI-5663213",
"REACTOME:R-HSA-2029482",
"REACTOM... | 24 | [
"1k8k",
"1tyq",
"1u2v",
"2p9i",
"2p9k",
"2p9l",
"2p9n",
"2p9p",
"2p9s",
"2p9u",
"3dwl",
"3dxk",
"3dxm",
"3rse",
"3ukr",
"3uku",
"3ule",
"4jd2",
"4xei",
"4xf2",
"6dec",
"6uhc",
"6w17",
"6w18",
"6yw6",
"6yw7",
"7aqk",
"7jpn",
"7t5q",
"7tpt",
"8e9b",
"8p94"... | 40 | [
"PUB00020552",
"PUB00022758",
"PUB00035127",
"PUB00035128"
] | [
"9889097",
"15505213",
"9600938",
"11752435"
] | [
"Scar1 and the related Wiskott-Aldrich syndrome protein, WASP, regulate the actin cytoskeleton through the Arp2/3 complex.",
"Crystal structures of actin-related protein 2/3 complex with bound ATP or ADP.",
"The interaction of Arp2/3 complex with actin: nucleation, high affinity pointed end capping, and formati... | [
1998,
2004,
1998,
2001
] | 4 | [] | [] | 0 | 0 | null | [
"Candidatus Heimdallarchaeum",
"Eukaryota"
] | [
2,
5540
] | 2 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
5,
1,
1,
1,
9,
6,
1,
5,
6,
1,
1,
8
] | 12 | true | Family | Actin-related protein 2/3 complex subunit 4 | Actin-related protein 2/3 complex subunit 4 | ARPC4 | 9 |
IPR008385 | 8,385 | African swine fever virus, Inner membrane protein p54 | ASFV_p54 | Family | 196 | false | false | This entry represents Inner membrane protein p54 from African swine fever virus (ASFV). This inner envelope protein is involved in the intracellular microtubule-dependent transport of viral capsid toward viral factories through its interaction with host dynein [ ]. It sems to induce caspase-3 activation and apoptosis [... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF05568"
] | [
"ASFV_J13L"
] | [
196
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00100307",
"PUB00100308"
] | [
"15225638",
"11559815"
] | [
"The African swine fever virus dynein-binding protein p54 induces infected cell apoptosis.",
"African swine fever virus protein p54 interacts with the microtubular motor complex through direct binding to light-chain dynein."
] | [
2004,
2001
] | 2 | [] | [] | 0 | 0 | null | [
"African swine fever virus",
"Bacteria",
"Eukaryota"
] | [
176,
7,
13
] | 3 | [] | [] | 0 | true | Family | African swine fever virus, Inner membrane protein p54 | African swine fever virus, Inner membrane protein p54 | ASFV_p54 | 3 |
IPR008386 | 8,386 | ATP synthase, F0 complex, subunit E, mitochondrial | ATP_synth_F0_esu_mt | Family | 3,141 | false | false | Transmembrane ATPases are membrane-bound enzyme complexes/ion transporters that use ATP hydrolysis to drive the transport of protons across a membrane. Some transmembrane ATPases also work in reverse, harnessing the energy from a proton gradient, using the flux of ions across the membrane via the ATPase proton channel ... | [
"GO:0015078",
"GO:0015986"
] | [
"proton transmembrane transporter activity",
"proton motive force-driven ATP synthesis"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PFAM",
"PANTHER"
] | [
"PF05680",
"PTHR12427"
] | [
"ATP-synt_E",
""
] | [
3139,
1628
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-163210",
"R-BTA-8949613",
"R-HSA-163210",
"R-HSA-8949613",
"R-MMU-163210",
"R-MMU-8949613",
"R-RNO-163210",
"R-RNO-8949613",
"R-SSC-163210",
"R-SSC-8949613"
] | [
"REACTOME:R-BTA-163210",
"REACTOME:R-BTA-8949613",
"REACTOME:R-HSA-163210",
"REACTOME:R-HSA-8949613",
"REACTOME:R-MMU-163210",
"REACTOME:R-MMU-8949613",
"REACTOME:R-RNO-163210",
"REACTOME:R-RNO-8949613",
"REACTOME:R-SSC-163210",
"REACTOME:R-SSC-8949613"
] | 10 | [
"6tt7",
"6za9",
"6zbb",
"6ziq",
"6zit",
"6ziu",
"6zmr",
"6zna",
"6zpo",
"6zqm",
"6zqn",
"7ajb",
"7ajc",
"7ajd",
"7aje",
"7ajf",
"7ajg",
"7ajh",
"7aji",
"7ajj",
"8h9f",
"8h9j",
"8h9m",
"8h9q",
"8h9s",
"8h9t",
"8h9u",
"8h9v",
"8khf",
"8ki3",
"9b0x",
"9b3j"... | 35 | [
"PUB00009752",
"PUB00020603",
"PUB00020604",
"PUB00020649",
"PUB00068786",
"PUB00068787",
"PUB00068788",
"PUB00068789"
] | [
"11309608",
"15473999",
"15078220",
"15701797",
"20450191",
"18937357",
"1385979",
"9741106"
] | [
"Resolution of distinct rotational substeps by submillisecond kinetic analysis of F1-ATPase.",
"The evolution of A-, F-, and V-type ATP synthases and ATPases: reversals in function and changes in the H+/ATP coupling ratio.",
"Mechanisms of ATPases--a multi-disciplinary approach.",
"Functional analysis of subu... | [
2001,
2004,
2004,
2005,
2010,
2008,
1992,
1998
] | 8 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota"
] | [
9,
3132
] | 2 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
... | [
1,
2,
1,
1,
3,
1,
2,
5,
1,
1,
3
] | 11 | true | Family | ATP synthase, F0 complex, subunit E, mitochondrial | ATP synthase, F0 complex, subunit E, mitochondrial | ATP_synth_F0_esu_mt | 6 |
IPR008387 | 8,387 | ATP synthase-coupling factor 6, mitochondrial | ATP_synth_f6_mt | Family | 2,159 | false | false | Transmembrane ATPases are membrane-bound enzyme complexes/ion transporters that use ATP hydrolysis to drive the transport of protons across a membrane. Some transmembrane ATPases also work in reverse, harnessing the energy from a proton gradient, using the flux of ions across the membrane via the ATPase proton channel ... | [
"GO:0015078",
"GO:0015986"
] | [
"proton transmembrane transporter activity",
"proton motive force-driven ATP synthesis"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PFAM",
"PIRSF",
"PANTHER"
] | [
"PF05511",
"PIRSF002455",
"PTHR12441"
] | [
"ATP-synt_F6",
"ATP_synthase_coupling_factor_6",
""
] | [
2157,
1141,
2036
] | 3 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-163210",
"R-BTA-8949613",
"R-BTA-9837999",
"R-DME-163210",
"R-DME-8949613",
"R-DME-9837999",
"R-HSA-163210",
"R-HSA-8949613",
"R-HSA-9837999",
"R-MMU-163210",
"R-MMU-8949613",
"R-MMU-9837999",
"R-RNO-163210",
"R-RNO-8949613",
"R-RNO-9837999"
] | [
"REACTOME:R-BTA-163210",
"REACTOME:R-BTA-8949613",
"REACTOME:R-BTA-9837999",
"REACTOME:R-DME-163210",
"REACTOME:R-DME-8949613",
"REACTOME:R-DME-9837999",
"REACTOME:R-HSA-163210",
"REACTOME:R-HSA-8949613",
"REACTOME:R-HSA-9837999",
"REACTOME:R-MMU-163210",
"REACTOME:R-MMU-8949613",
"REACTOME:R-... | 15 | [
"1vzs",
"2cly",
"2wss",
"4b2q",
"5ara",
"5are",
"5arh",
"5ari",
"5fij",
"5fik",
"5fil",
"6j5i",
"6j5j",
"6j5k",
"6tt7",
"6yy0",
"6z1r",
"6z1u",
"6ziq",
"6zit",
"6ziu",
"6zpo",
"6zqm",
"6zqn",
"7ajb",
"7ajc",
"7ajd",
"7aje",
"7ajf",
"7ajg",
"7ajh",
"7aji"... | 46 | [
"PUB00009752",
"PUB00020603",
"PUB00020604",
"PUB00020607",
"PUB00068786",
"PUB00068787",
"PUB00068788",
"PUB00068789"
] | [
"11309608",
"15473999",
"15078220",
"16045926",
"20450191",
"18937357",
"1385979",
"9741106"
] | [
"Resolution of distinct rotational substeps by submillisecond kinetic analysis of F1-ATPase.",
"The evolution of A-, F-, and V-type ATP synthases and ATPases: reversals in function and changes in the H+/ATP coupling ratio.",
"Mechanisms of ATPases--a multi-disciplinary approach.",
"Structure of the F1-binding... | [
2001,
2004,
2004,
2005,
2010,
2008,
1992,
1998
] | 8 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
2159
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
9,
4,
4,
3,
4
] | 6 | true | Family | ATP synthase-coupling factor 6, mitochondrial | ATP synthase-coupling factor 6, mitochondrial | ATP_synth_f6_mt | 3 |
IPR008389 | 8,389 | ATPase, V0 complex, subunit e1/e2 | ATPase_V0-cplx_e1/e2_su | Family | 4,338 | false | false | Transmembrane ATPases are membrane-bound enzyme complexes/ion transporters that use ATP hydrolysis to drive the transport of protons across a membrane. Some transmembrane ATPases also work in reverse, harnessing the energy from a proton gradient, using the flux of ions across the membrane via the ATPase proton channel ... | [
"GO:0046961",
"GO:1902600",
"GO:0033179"
] | [
"proton-transporting ATPase activity, rotational mechanism",
"proton transmembrane transport",
"proton-transporting V-type ATPase, V0 domain"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PFAM",
"PANTHER"
] | [
"PF05493",
"PTHR12263"
] | [
"ATP_synt_H",
""
] | [
4299,
3899
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-1222556",
"R-BTA-77387",
"R-BTA-917977",
"R-BTA-9639288",
"R-BTA-983712",
"R-CEL-1222556",
"R-CEL-77387",
"R-CEL-917977",
"R-CEL-9639288",
"R-CEL-983712",
"R-HSA-1222556",
"R-HSA-77387",
"R-HSA-917977",
"R-HSA-9639288",
"R-HSA-983712",
"R-HSA-9857377",
"R-MMU-1222556",
"R-MM... | [
"REACTOME:R-BTA-1222556",
"REACTOME:R-BTA-77387",
"REACTOME:R-BTA-917977",
"REACTOME:R-BTA-9639288",
"REACTOME:R-BTA-983712",
"REACTOME:R-CEL-1222556",
"REACTOME:R-CEL-77387",
"REACTOME:R-CEL-917977",
"REACTOME:R-CEL-9639288",
"REACTOME:R-CEL-983712",
"REACTOME:R-HSA-1222556",
"REACTOME:R-HSA-... | 34 | [
"5tj5",
"5vox",
"5voy",
"5voz",
"6c6l",
"6m0r",
"6m0s",
"6o7t",
"6o7u",
"6o7v",
"6o7w",
"6o7x",
"6pe4",
"6pe5",
"6vq6",
"6vq7",
"6vq8",
"6vqc",
"6vqg",
"6vqh",
"6wlw",
"6wm2",
"6wm3",
"6wm4",
"6xbw",
"7fda",
"7fdb",
"7fdc",
"7khr",
"7tao",
"7tap",
"7tmr"... | 70 | [
"PUB00011242",
"PUB00020603",
"PUB00020604",
"PUB00020608",
"PUB00020609",
"PUB00020638",
"PUB00042803",
"PUB00068786",
"PUB00068787",
"PUB00068788",
"PUB00068789"
] | [
"9556572",
"15473999",
"15078220",
"15907459",
"15629643",
"12544825",
"12163484",
"20450191",
"18937357",
"1385979",
"9741106"
] | [
"Identification and characterization of a novel 9.2-kDa membrane sector-associated protein of vacuolar proton-ATPase from chromaffin granules.",
"The evolution of A-, F-, and V-type ATP synthases and ATPases: reversals in function and changes in the H+/ATP coupling ratio.",
"Mechanisms of ATPases--a multi-disci... | [
1998,
2004,
2004,
2005,
2005,
2003,
2002,
2010,
2008,
1992,
1998
] | 11 | [] | [
"IPR017385"
] | 0 | 1 | 0 | [
"Eukaryota"
] | [
4338
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
5,
1,
4,
8,
7,
6,
1,
2,
7,
1,
1,
6
] | 12 | true | Family | ATPase, V0 complex, subunit e1/e2 | ATPase, V0 complex, subunit e1/e2 | ATPase_V0-cplx_e1/e2_su | 8 |
IPR008390 | 8,390 | AWPM-19-like | AWPM-19 | Family | 2,578 | false | false | Members of this family are 19kDa membrane proteins. The levels of the plant protein AWPM-19 increase dramatically when there is an increase level of abscisic acid. The increase presence of this protein leads to greater tolerance of freezing [ ]. The rice homologue, OsPM19L1, is induced by osmotic stress and may be asso... | [] | [] | [] | 0 | [
"PFAM",
"PANTHER"
] | [
"PF05512",
"PTHR33294"
] | [
"AWPM-19",
""
] | [
2576,
2485
] | 2 | [] | [] | [] | 0 | [] | 0 | [
"PUB00011243",
"PUB00088044"
] | [
"9249988",
"26505346"
] | [
"Accumulation of 19-kDa plasma membrane polypeptide during induction of freezing tolerance in wheat suspension-cultured cells by abscisic acid.",
"Characterization of OsPM19L1 encoding an AWPM-19-like family protein that is dramatically induced by osmotic stress in rice."
] | [
1997,
2015
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
2578
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
11,
19,
14
] | 3 | true | Family | AWPM-19-like | AWPM-19-like | AWPM-19 | 8 |
IPR008391 | 8,391 | Acetyl xylan esterase domain | AXE1_dom | Domain | 7,825 | false | false | This domain can be found in several bacterial acetyl xylan esterase proteins. Acetyl xylan esterases are enzymes that hydrolyse the ester linkages of the acetyl groups in position 2 and/or 3 of the xylose moieties of natural acetylated xylan from hardwood. These enzymes are one of the accessory enzymes which are part o... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF05448"
] | [
"AXE1"
] | [
7825
] | 1 | [] | [] | [] | 0 | [
"1l7a",
"1ods",
"1odt",
"1vlq",
"2xlb",
"2xlc",
"3fcy",
"3fvr",
"3fvt",
"3fyt",
"3fyu",
"3m81",
"3m82",
"3m83",
"5fdf",
"5gma",
"5hfn",
"5jib",
"6agq",
"6fkx",
"7xmj"
] | 21 | [
"PUB00011244"
] | [
"10878123"
] | [
"The acetyl xylan esterase of Bacillus pumilus belongs to a family of esterases with broad substrate specificity."
] | [
2000
] | 1 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
68,
7562,
80,
115
] | 4 | [
"Arabidopsis thaliana"
] | [
7
] | 1 | true | Domain | Acetyl xylan esterase domain | Acetyl xylan esterase domain | AXE1_dom | 8 |
IPR008392 | 8,392 | Drosophila accessory gland-specific peptide 26Ab | Acp26Ab | Family | 23 | false | false | This family consists of accessory gland-specific 26Ab peptides or male accessory gland secretory protein 355B from different Drosophila species. Drosophila males, like males of most other insects, transfer a group of specific proteins (Acp26Ab and Acp26Aa in Drosophila) to the females during mating. These proteins are ... | [
"GO:0007617",
"GO:0005576"
] | [
"mating behavior",
"extracellular region"
] | [
"biological_process",
"cellular_component"
] | 2 | [
"PFAM"
] | [
"PF05777"
] | [
"Acp26Ab"
] | [
23
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00011245"
] | [
"1361475"
] | [
"Polymorphism and divergence in the Mst26A male accessory gland gene region in Drosophila."
] | [
1992
] | 1 | [] | [] | 0 | 0 | null | [
"Sophophora"
] | [
23
] | 1 | [
"Drosophila melanogaster"
] | [
2
] | 1 | true | Family | Drosophila accessory gland-specific peptide 26Ab | Drosophila accessory gland-specific peptide 26Ab | Acp26Ab | 7 |
IPR008393 | 8,393 | Adenovirus late L2 mu core | Adenovirus_late_L2_mu_core | Family | 311 | false | false | The late transcription region 2 (L2) of Adenovirus type 2 has an ORF of 80 residues positioned between nucleotides 17,676 and 17,915. It encodes an 11K polypeptide, which has the initiating methionine residue removed, leaving a 79-residue product. The L2 region that encoded 11K polypeptide is arginine rich (21%) and ha... | [
"GO:0003677",
"GO:0019013"
] | [
"DNA binding",
"viral nucleocapsid"
] | [
"molecular_function",
"cellular_component"
] | 2 | [
"PFAM"
] | [
"PF05829"
] | [
"Adeno_PX"
] | [
311
] | 1 | [] | [] | [] | 0 | [
"9lr9"
] | 1 | [
"PUB00011541"
] | [
"3357209"
] | [
"Identification of the gene coding for the precursor of adenovirus core protein X."
] | [
1988
] | 1 | [] | [] | 0 | 0 | null | [
"Mycobacterium simiae",
"Nesidiocoris tenuis",
"Viruses"
] | [
1,
1,
309
] | 3 | [] | [] | 0 | true | Family | Adenovirus late L2 mu core | Adenovirus late L2 mu core | Adenovirus_late_L2_mu_core | 9 |
IPR008394 | 8,394 | Enterobacteria AfaD invasin | AfaD | Family | 665 | false | false | This family consists of several AfaD and related proteins from Escherichia coli and Salmonella bacteria. The afa gene clusters encode an afimbrial adhesive sheath produced by E. coli. The adhesive sheath is composed of two proteins, AfaD and AfaE, which are independently exposed at the bacterial cell surface. AfaE is r... | [] | [] | [] | 0 | [
"PFAM",
"CDD"
] | [
"PF05775",
"cd18776"
] | [
"AfaD",
"AfaD-like"
] | [
664,
629
] | 2 | [] | [] | [] | 0 | [
"2axw",
"2fvn",
"2ixq",
"3uiy",
"3uiz",
"4or1",
"4phx",
"5d55",
"5y9g",
"5y9h"
] | 10 | [
"PUB00011246",
"PUB00039446",
"PUB00040832",
"PUB00097369",
"PUB00139344",
"PUB00139345",
"PUB00139346",
"PUB00139347"
] | [
"10981717",
"16421447",
"16965519",
"25232738",
"27400770",
"29125121",
"22497887",
"10074069"
] | [
"Characterization of the AfaD-like family of invasins encoded by pathogenic Escherichia coli associated with intestinal and extra-intestinal infections.",
"Structure of DraD invasin from uropathogenic Escherichia coli: a dimer with swapped beta-tails.",
"The solution structure of the invasive tip complex from A... | [
2000,
2006,
2006,
2014,
2016,
2017,
2012,
1999
] | 8 | [] | [] | 0 | 0 | null | [
"Gammaproteobacteria"
] | [
665
] | 1 | [] | [] | 0 | true | Family | Enterobacteria AfaD invasin | Enterobacteria AfaD invasin | AfaD | 5 |
IPR008395 | 8,395 | Agenet-like domain | Agenet-like_dom | Domain | 16,763 | false | false | Fragile X messenger ribonucleoprotein 1 (FMR1/FMRP), and its autosomal paralogues, RNA-binding proteins FXR1/2 (Fragile X-related protein 1/2), comprise a family of RNA-binding proteins that are involved the regulation of alternative mRNA splicing, mRNA stability, mRNA dendritic transport and postsynaptic local protein... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF05641"
] | [
"Agenet"
] | [
16763
] | 1 | [
"REACTOME"
] | [
"R-HSA-6802952"
] | [
"REACTOME:R-HSA-6802952"
] | 1 | [
"2bkd",
"3h8z",
"3kuf",
"3o8v",
"4ova",
"4qvz",
"4qw2",
"5zwx",
"5zwz",
"6ie4",
"6ie5",
"6ie6",
"6ie7",
"7yt9",
"7yta"
] | 15 | [
"PUB00011247",
"PUB00039656",
"PUB00054919",
"PUB00060514",
"PUB00060515",
"PUB00086467",
"PUB00090595",
"PUB00090596",
"PUB00091115",
"PUB00091337",
"PUB00103107",
"PUB00103108"
] | [
"12575993",
"16407062",
"16000371",
"12950170",
"21072162",
"19795213",
"28960184",
"29713264",
"25416280",
"25464849",
"30382101",
"30425322"
] | [
"The Tudor domain 'Royal Family': Tudor, plant Agenet, Chromo, PWWP and MBT domains.",
"The structure of the N-terminal domain of the fragile X mental retardation protein: a platform for protein-protein interaction.",
"The RNA-binding protein fragile X-related 1 regulates somite formation in Xenopus laevis.",
... | [
2003,
2006,
2005,
2003,
2010,
2010,
2017,
2018,
2015,
2014,
2018,
2019
] | 12 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota"
] | [
122,
16641
] | 2 | [
"Arabidopsis thaliana",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
111,
5,
32,
16,
44,
20,
116
] | 7 | true | Domain | Agenet-like domain | Agenet-like domain | Agenet-like_dom | 6 |
IPR008397 | 8,397 | Alginate lyase domain | Alginate_lyase_dom | Domain | 10,726 | false | false | Alginate is a family of 1-4-linked copolymers of beta-D-mannuronic acid (M) and alpha-L-guluronic acid (G). It is produced by brown algae and by some bacteria belonging to the genera Azotobacter and Pseudomonas. Alginate lyases catalyse the depolymerisation of alginates by beta -elimination, generating a molecule conta... | [
"GO:0016829",
"GO:0042597"
] | [
"lyase activity",
"periplasmic space"
] | [
"molecular_function",
"cellular_component"
] | 2 | [
"PFAM"
] | [
"PF05426"
] | [
"Alginate_lyase"
] | [
10726
] | 1 | [
"EC",
"METACYC"
] | [
"4.2.2.3",
"PWY-6986"
] | [
"EC:4.2.2.3",
"METACYC:PWY-6986"
] | 2 | [
"1hv6",
"1qaz",
"3nfv",
"3nnb",
"4e1y",
"4f10",
"4f13",
"4nei",
"4ojz",
"4ok2",
"4ok4",
"4ozv",
"4ozw",
"7bjt",
"7bm6",
"7fhu",
"7fhv",
"7fhw",
"7fhx",
"7fhy",
"7fhz",
"7fi0",
"7fi1",
"7fi2",
"7sa8",
"7wxj",
"7wxk",
"7wxl",
"7wxm",
"7wxn",
"7wxo",
"7wxp"... | 53 | [
"PUB00011248"
] | [
"9683471"
] | [
"Biochemical properties and substrate specificities of a recombinantly produced Azotobacter vinelandii alginate lyase."
] | [
1998
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Stenosarchaea group",
"metagenomes"
] | [
8433,
2225,
36,
32
] | 4 | [] | [] | 0 | true | Domain | Alginate lyase domain | Alginate lyase domain | Alginate_lyase_dom | 1 |
IPR008398 | 8,398 | Allexivirus 40kDa | Allexi_40kDa | Family | 184 | false | false | This family of sequences contains the 40kDa polypeptides from garlic viruses (Allexiviruses), which do not resemble any other plant virus gene products reported so far [ ]. Rod-shaped flexuous viruses have been isolated from garlic plants, Allium sativum. Infection by this virus creates typical mosaic symptoms. The cor... | [] | [] | [] | 0 | [
"PFAM",
"PIRSF"
] | [
"PF05549",
"PIRSF005512"
] | [
"Allexi_40kDa",
"Allexi_40kDa"
] | [
184,
157
] | 2 | [] | [] | [] | 0 | [] | 0 | [
"PUB00011537",
"PUB00043798"
] | [
"8376963",
"18092468"
] | [
"Novel rod-shaped viruses isolated from garlic, Allium sativum, possessing a unique genome organization.",
"Allexivirus transmitted by eriophyid mites in garlic plants."
] | [
1993,
2007
] | 2 | [] | [] | 0 | 0 | null | [
"Tymovirales"
] | [
184
] | 1 | [] | [] | 0 | true | Family | Allexivirus 40kDa | Allexivirus 40kDa | Allexi_40kDa | 7 |
IPR008399 | 8,399 | Anthrax toxin receptor, C-terminal | Anthrax_toxin_rcpt_C | Domain | 4,096 | false | false | Anthrax is an acute disease in humans and animals, which is caused by the bacterium Bacillus anthracis. While the disease can be lethal, there are effective vaccines against anthrax, and some forms of the disease respond well to antibiotic treatment. The anthrax toxin consists of the proteins protective antigen (PA), l... | [
"GO:0038023",
"GO:0016020"
] | [
"signaling receptor activity",
"membrane"
] | [
"molecular_function",
"cellular_component"
] | 2 | [
"PFAM"
] | [
"PF05586"
] | [
"Ant_C"
] | [
4096
] | 1 | [
"REACTOME"
] | [
"R-HSA-5210891"
] | [
"REACTOME:R-HSA-5210891"
] | 1 | [] | 0 | [
"PUB00022677",
"PUB00031351"
] | [
"15079089",
"15243628"
] | [
"Crystal structure of the von Willebrand factor A domain of human capillary morphogenesis protein 2: an anthrax toxin receptor.",
"Crystal structure of a complex between anthrax toxin and its host cell receptor."
] | [
2004,
2004
] | 2 | [] | [] | 0 | 0 | null | [
"Metazoa"
] | [
4096
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
13,
7,
6,
10
] | 4 | true | Domain | Anthrax toxin receptor, C-terminal | Anthrax toxin receptor, C-terminal | Anthrax_toxin_rcpt_C | 5 |
IPR008400 | 8,400 | Anthrax toxin receptor, extracellular domain | Anthrax_toxin_rcpt_extracel | Domain | 4,271 | false | false | Anthrax is an acute disease in humans and animals, which is caused by the bacterium Bacillus anthracis. While the disease can be lethal, there are effective vaccines against anthrax, and some forms of the disease respond well to antibiotic treatment. The anthrax toxin consists of the proteins protective antigen (PA), l... | [
"GO:0038023",
"GO:0016020"
] | [
"signaling receptor activity",
"membrane"
] | [
"molecular_function",
"cellular_component"
] | 2 | [
"PFAM"
] | [
"PF05587"
] | [
"Anth_Ig"
] | [
4271
] | 1 | [
"REACTOME"
] | [
"R-HSA-5210891"
] | [
"REACTOME:R-HSA-5210891"
] | 1 | [] | 0 | [
"PUB00022677",
"PUB00031351"
] | [
"15079089",
"15243628"
] | [
"Crystal structure of the von Willebrand factor A domain of human capillary morphogenesis protein 2: an anthrax toxin receptor.",
"Crystal structure of a complex between anthrax toxin and its host cell receptor."
] | [
2004,
2004
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
4271
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
13,
21,
10,
15
] | 4 | true | Domain | Anthrax toxin receptor, extracellular domain | Anthrax toxin receptor, extracellular domain | Anthrax_toxin_rcpt_extracel | 6 |
IPR008401 | 8,401 | Apc13 | Apc13 | Family | 2,698 | false | false | The anaphase-promoting complex (APC) is a conserved multi-subunit ubiquitin ligase required for the degradation of key cell cycle regulators. Members of this family are components of the anaphase-promoting complex homologous to Apc13 [ ]. | [
"GO:0005680"
] | [
"anaphase-promoting complex"
] | [
"cellular_component"
] | 1 | [
"PFAM",
"PANTHER"
] | [
"PF05839",
"PTHR28672"
] | [
"Apc13p",
""
] | [
2381,
1490
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-983168",
"R-HSA-983168",
"R-MMU-983168",
"R-XTR-983168"
] | [
"REACTOME:R-BTA-983168",
"REACTOME:R-HSA-983168",
"REACTOME:R-MMU-983168",
"REACTOME:R-XTR-983168"
] | 4 | [
"4ui9",
"5a31",
"5g04",
"5g05",
"5khr",
"5khu",
"5l9t",
"5l9u",
"5lcw",
"6q6g",
"6q6h",
"6tlj",
"6tm5",
"6tnt",
"8a3t",
"8a5y",
"8a61",
"8pkp",
"8tar",
"8tau",
"9gaw",
"9n9r",
"9n9s"
] | 23 | [
"PUB00011249"
] | [
"12477395"
] | [
"Proteomics analysis identifies new components of the fission and budding yeast anaphase-promoting complexes."
] | [
2002
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
2698
] | 1 | [
"Arabidopsis thaliana",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"... | [
3,
1,
2,
2,
1,
1,
3,
2,
1,
1,
3
] | 11 | true | Family | Apc13 | Apc13 | Apc13 | 1 |
IPR008402 | 8,402 | Anaphase-promoting complex subunit 15/mnd2, N-terminal | APC_su15/mnd2_N | Domain | 1,149 | false | false | This entry represents a conserved region found at the N-terminal of budding yeast Mnd2 and its homologue, anaphase-promoting complex subunit 15 (Apc15), from fission yeasts [ ]. They are part of the anaphase promoting complex/cyclosome (APC/C) [ , ]. The anaphase-promoting complex (APC) or cyclosome is a multi-subunit ... | [
"GO:0031145",
"GO:0005680"
] | [
"anaphase-promoting complex-dependent catabolic process",
"anaphase-promoting complex"
] | [
"biological_process",
"cellular_component"
] | 2 | [
"PFAM"
] | [
"PF05841"
] | [
"Apc15p"
] | [
1149
] | 1 | [] | [] | [] | 0 | [
"8a3t",
"8a5y",
"8a61"
] | 3 | [
"PUB00011249",
"PUB00055007",
"PUB00059221"
] | [
"12477395",
"12609981",
"18485873"
] | [
"Proteomics analysis identifies new components of the fission and budding yeast anaphase-promoting complexes.",
"Mnd2 and Swm1 are core subunits of the Saccharomyces cerevisiae anaphase-promoting complex.",
"Mechanism of ubiquitin-chain formation by the human anaphase-promoting complex."
] | [
2002,
2003,
2008
] | 3 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1149
] | 1 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
1,
1,
1
] | 3 | true | Domain | Anaphase-promoting complex subunit 15/mnd2, N-terminal | Anaphase-promoting complex subunit 15/mnd2, N-terminal | APC_su15/mnd2_N | 3 |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.