LiteFold/InterPro · Datasets at Hugging Face

IPR008524

8,524

Protein of unknown function DUF806

DUF806

Family

422

false

This family consists of several Siphovirus and Lactococcus proteins of unknown function. The viral sequences are thought to be tail component proteins.

[]

0

[ "PFAM" ]

[ "PF05657" ]

[ "DUF806" ]

[ 422 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacilli", "Viruses" ]

[ 321, 101 ]

2

[]

0

true

Family

Protein of unknown function DUF806

DUF806

8

IPR008525

8,525

Protein of unknown function DUF807, Coxiella burnetii

DUF807_COXBU

Family

15

false

This family consists of several proteins of unknown function from Coxiella burnetii (the causative agent of a zoonotic disease called Q fever).

[]

0

[ "PFAM" ]

[ "PF05660" ]

[ "DUF807" ]

[ 15 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Plasmid pH1" ]

[ 14, 1 ]

2

[]

0

true

Family

Protein of unknown function DUF807, Coxiella burnetii

DUF807_COXBU

2

IPR008526

8,526

Inner membrane protein YedI

YedI

Family

9,285

false

This family of proteins includes inner membrane protein YedI.

[]

0

[ "PFAM", "PIRSF", "PANTHER" ]

[ "PF05661", "PIRSF016660", "PTHR30503" ]

[ "DUF808", "YedI", "" ]

[ 9281, 8950, 9270 ]

3

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 9216, 18, 51 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Inner membrane protein YedI

YedI

2

IPR008527

8,527

Protein of unknown function DUF809

DUF809

Family

18

false

This family consists of several proteins of unknown function from Raphanus sativus (Radish) and Brassica napus (Rape).

[]

0

[ "PFAM" ]

[ "PF05663" ]

[ "DUF809" ]

[ 18 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Brassiceae" ]

[ 18 ]

1

[]

0

true

Family

Protein of unknown function DUF809

DUF809

2

IPR008528

8,528

Protein unc-13 homologue

PATROL

Family

4,536

false

This family consists mainly of uncharacterised proteins from plants. The unc-13 homologue from Arabidopsis thaliana has been shown to control tethering of the proton ATPase AHA1 to the plasma membrane, and to be essential for the opening of stomata in repsonse to low levels of carbon dioxide and light. The unc13-like p...

[]

0

[ "PANTHER" ]

[ "PTHR31280" ]

[ "" ]

[ 4536 ]

1

[]

0

[]

0

[ "PUB00088405" ]

[ "23896897" ]

[ "A Munc13-like protein in Arabidopsis mediates H+-ATPase translocation that is essential for stomatal responses." ]

[ 2013 ]

1

[]

0

null

[ "Eukaryota" ]

[ 4536 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 39, 35, 64 ]

3

true

Family

Protein unc-13 homologue

PATROL

1

IPR008530

8,530

Coiled-coil domain-containing protein 22

CCDC22

Family

2,245

false

Human coiled-coil domain-containing protein 22 (CCDC22) is involved in regulation of NF-kappa-B signalling; the function may involve association with COMMD8 and a CUL1-dependent E3 ubiquitin ligase complex [ ]. It is part of the OMMD/CCDC22/CCDC93 (CCC) complex, which interacts with the multisubunit WASH complex requir...

[]

0

[ "PANTHER" ]

[ "PTHR15668" ]

[ "" ]

[ 2245 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-8951664", "R-DDI-8951664", "R-DME-8951664", "R-DRE-8951664", "R-HSA-8951664", "R-MMU-8951664", "R-RNO-8951664" ]

[ "REACTOME:R-BTA-8951664", "REACTOME:R-DDI-8951664", "REACTOME:R-DME-8951664", "REACTOME:R-DRE-8951664", "REACTOME:R-HSA-8951664", "REACTOME:R-MMU-8951664", "REACTOME:R-RNO-8951664" ]

7

[ "8f2u", "8p0v", "8p0w", "8p0x" ]

4

[ "PUB00077065", "PUB00077066" ]

[ "23563313", "25355947" ]

[ "CCDC22 deficiency in humans blunts activation of proinflammatory NF-κB signaling.", "COMMD1 is linked to the WASH complex and regulates endosomal trafficking of the copper transporter ATP7A." ]

[ 2013, 2015 ]

2

[]

0

null

[ "Eukaryota" ]

[ 2245 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 6, 2, 1, 1, 4, 1, 3 ]

7

true

Family

Coiled-coil domain-containing protein 22

CCDC22

8

IPR008533

8,533

Protein of unknown function DUF815

DUF815

Family

8,041

false

This entry represents a family of bacterial proteins of unknown function. Many members contain an AAA+ ATPase domain ( ).

[]

0

[ "PFAM", "PANTHER" ]

[ "PF05673", "PTHR42935" ]

[ "DUF815", "" ]

[ 8015, 7991 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "phage Lak_Megaphage_Sonny", "unclassified sequences" ]

[ 40, 7810, 112, 1, 78 ]

5

[]

0

true

Family

Protein of unknown function DUF815

DUF815

1

IPR008534

8,534

Baculovirus protein of unknown function DUF816

DUF816

Family

152

false

This family includes proteins that are about 200 amino acids in length. The proteins are all from baculoviruses. This family includes ORF107 from Orgyia pseudotsugata multicapsid polyhedrosis virus (OpMNPV) and a variety of other numbered ORF proteins, such as ORF52 , ORF140 from other baculoviruses. The function of th...

[]

0

[ "PFAM" ]

[ "PF05674" ]

[ "DUF816" ]

[ 152 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Baculoviridae" ]

[ 152 ]

1

[]

0

true

Family

Baculovirus protein of unknown function DUF816

DUF816

1

IPR008535

8,535

Protein of unknown function DUF817

DUF817

Family

3,436

false

This family consists of several bacterial proteins of unknown function.

[]

0

[ "PFAM", "PIRSF" ]

[ "PF05675", "PIRSF009141" ]

[ "DUF817", "UCP009141" ]

[ 3436, 3157 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 3429, 4, 3 ]

3

[]

0

true

Family

Protein of unknown function DUF817

DUF817

2

IPR008537

8,537

Protein of unknown function DUF819

DUF819

Family

5,247

false

This family contains proteins of unknown function from archaeal, bacterial and plant species.

[]

0

[ "PFAM", "PANTHER" ]

[ "PF05684", "PTHR34289" ]

[ "DUF819", "" ]

[ 5231, 5111 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Thermococcaceae", "ecological metagenomes" ]

[ 3594, 1583, 8, 62 ]

4

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 8, 7, 4 ]

3

true

Family

Protein of unknown function DUF819

DUF819

4

IPR008538

8,538

Putative restriction endonuclease

Uma2

Domain

45,174

false

This entry includes a group of putative nuclease, including hypothetical protein TT1808 (also known as Uma2 or TTHA1514), an AT-rich DNA-binding protein from Thermus thermophilus. This domain has a 3-layer α/β/α topology similar to that found in restriction endonucleases [ ]. The nuclease domain is ubiquitously found i...

[]

0

[ "PFAM", "CDD" ]

[ "PF05685", "cd06260" ]

[ "Uma2", "DUF820-like" ]

[ 45051, 42888 ]

2

[]

0

[ "1wdj", "3ot2", "6okh", "9y1l" ]

4

[ "PUB00035698", "PUB00035699" ]

[ "17154156", "15720711" ]

[ "Crystal structure of TTHA1657 (AT-rich DNA-binding protein; p25) from Thermus thermophilus HB8 at 2.16 A resolution.", "Identification of a new family of putative PD-(D/E)XK nucleases with unusual phylogenomic distribution and a new type of the active site." ]

[ 2007, 2005 ]

2

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified Caudoviricetes", "unclassified sequences" ]

[ 2, 44324, 740, 3, 105 ]

5

[]

0

true

Domain

Putative restriction endonuclease

Uma2

2

IPR008540

8,540

BES1/BZR1 plant transcription factor, N-terminal

BES1_N

Domain

4,629

false

This entry represents the N-terminal regions of several plant transcription factors. It is classified as BES1/BZR1, a plant-specific transcription factor that cooperates with transcription factors such as BIM1 to regulate brassinosteroid-induced genes [ ]. Proteins containing this domain are transcriptional repressors ...

[]

0

[ "PFAM" ]

[ "PF05687" ]

[ "BES1_N" ]

[ 4629 ]

1

[]

0

[ "5zd4", "7vn2", "7vn3", "7vn4", "7vn5", "7vn6", "7vn7", "7vn8", "9m73", "9m74" ]

10

[ "PUB00016668", "PUB00075707" ]

[ "15681342", "15680330" ]

[ "BZR1 is a transcriptional repressor with dual roles in brassinosteroid homeostasis and growth responses.", "A new class of transcription factors mediates brassinosteroid-regulated gene expression in Arabidopsis." ]

[ 2005, 2005 ]

2

[]

0

null

[ "Streptophyta" ]

[ 4629 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 30, 15, 53 ]

3

true

Domain

BES1/BZR1 plant transcription factor, N-terminal

BES1_N

5

IPR008541

8,541

InvasinE, adhesion domain

InvE_AD

Domain

2,341

false

This entry represents the Adhesion domain found in InvasinE (InvE) from Yersinia pseudotuberculosis ( ). Invasins are members of the inverse autotransporter (IAT) family also referred to as type Ve secretion system. In general, they consist of an N-terminal β-barrel-like domain, which is responsible for attachment of i...

[]

0

[ "PFAM" ]

[ "PF05689" ]

[ "InvE_AD" ]

[ 2341 ]

1

[]

0

[ "5n40" ]

1

[ "PUB00016646", "PUB00016647", "PUB00101290" ]

[ "12540539", "15347755", "28370712" ]

[ "Molecular and phenotypic analysis of the CS54 island of Salmonella enterica serotype typhimurium: identification of intestinal colonization and persistence determinants.", "Genomic subtraction for the identification of putative new virulence factors of an avian pathogenic Escherichia coli strain of O2 serogroup....

[ 2003, 2004, 2017 ]

3

[]

0

null

[ "Bacteria" ]

[ 2341 ]

1

[]

0

true

Domain

InvasinE, adhesion domain

InvE_AD

1

IPR008542

8,542

Bacterial Immunoglobulin-like 21

BIg21

Domain

2,204

false

This entry represents the Bacterial Immunoglobulin-like 21 (BIg21) domain found in InvasinE (InvE). Invasins are members of the inverse autotransporter (IAT) family also referred to as type Ve secretion system. In general, they consist of an N-terminal β-barrel-like domain, which is responsible for attachment of invasi...

[]

0

[ "PFAM" ]

[ "PF05688" ]

[ "BIg21" ]

[ 2204 ]

1

[]

0

[ "5n40" ]

1

[ "PUB00016646", "PUB00016647", "PUB00101290" ]

[ "12540539", "15347755", "28370712" ]

[ "Molecular and phenotypic analysis of the CS54 island of Salmonella enterica serotype typhimurium: identification of intestinal colonization and persistence determinants.", "Genomic subtraction for the identification of putative new virulence factors of an avian pathogenic Escherichia coli strain of O2 serogroup....

[ 2003, 2004, 2017 ]

3

[]

0

null

[ "Bacteria", "freshwater metagenome" ]

[ 2203, 1 ]

2

[]

0

true

Domain

Bacterial Immunoglobulin-like 21

BIg21

3

IPR008543

8,543

Uncharacterised protein family Ycf2

Uncharacterised_Ycf2

Family

12,259

false

This family consists of chloroplast encoded Ycf2, which is around 2000 residues in length. Ycf2 is a component of the Ycf2-FtsHi complex which has been identified as chloroplast import motor. The Ycf2-FtsHi complex is composed of six distinct components. This heterohexameric assembly is organized in a counterclockwise ...

[]

0

[ "HAMAP" ]

[ "MF_01330" ]

[ "Ycf2" ]

[ 12259 ]

1

[]

0

[ "8xku", "8xkv" ]

2

[ "PUB00011516", "PUB00159880" ]

[ "10792825", "39197452" ]

[ "The two largest chloroplast genome-encoded open reading frames of higher plants are essential genes.", "Structural insights into the chloroplast protein import in land plants." ]

[ 2000, 2024 ]

2

[]

0

null

[ "Eukaryota", "Rhodopirellula halodulae" ]

[ 12258, 1 ]

2

[ "Arabidopsis thaliana" ]

[ 6 ]

1

true

Family

Uncharacterised protein family Ycf2

Uncharacterised_Ycf2

1

IPR008544

8,544

Protein of unknown function DUF826

DUF826

Family

431

false

This family consists of several enterobacterial and caudovirales sequences of unknown function. The characteristics of the protein distribution suggest prophage matches in addition to the phage matches.

[]

0

[ "PFAM" ]

[ "PF05696" ]

[ "DUF826" ]

[ 431 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Pseudomonadati", "Viruses" ]

[ 362, 69 ]

2

[]

0

true

Family

Protein of unknown function DUF826

DUF826

9

IPR008545

8,545

WEB family

Web

Family

6,469

false

Proteins in this family include WEB1 (At2g26570) and PMI15 (At5g38150) from Arabidopsis thaliana. Both Web1 and PMI15 are required for the chloroplast avoidance response under high intensity blue light. This avoidance response consists in the relocation of chloroplasts on the anticlinal side of exposed cells. Web1 acts...

[]

0

[ "PFAM" ]

[ "PF05701" ]

[ "WEMBL" ]

[ 6469 ]

1

[]

0

[]

0

[ "PUB00066738", "PUB00066739" ]

[ "20974974", "16778016" ]

[ "Two interacting coiled-coil proteins, WEB1 and PMI2, maintain the chloroplast photorelocation movement velocity in Arabidopsis.", "Plastid movement impaired 2, a new gene involved in normal blue-light-induced chloroplast movements in Arabidopsis." ]

[ 2010, 2006 ]

2

[]

0

null

[ "Bacillus phage vB_BsuM-Goe3", "Bacteria", "Eukaryota" ]

[ 1, 3, 6465 ]

3

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 59, 28, 53 ]

3

true

Family

WEB family

Web

6

IPR008546

8,546

VAN3-binding protein-like, auxin canalisation domain

VAN3-bd-like_auxin_canal

Domain

4,478

false

This domain can be found at the N-terminal end of several plant proteins, including VAN3-binding protein from Arabidopsis thaliana (also known as FORKED1), a component of the auto-regulatory loop which enables auxin canalisation by recruitment of the PIN1 auxin efflux protein to the cell membrane [ ]. This domain is fr...

[]

0

[ "PFAM" ]

[ "PF05703" ]

[ "Auxin_canalis" ]

[ 4478 ]

1

[]

0

[]

0

[ "PUB00090780" ]

[ "20626652" ]

[ "FORKED1 encodes a PH domain protein that is required for PIN1 localization in developing leaf veins." ]

[ 2010 ]

1

[]

0

null

[ "Streptophyta" ]

[ 4478 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 58, 36, 47 ]

3

true

Domain

VAN3-binding protein-like, auxin canalisation domain

VAN3-bd-like_auxin_canal

4

IPR008547

8,547

Protein of unknown function DUF829, TMEM53

DUF829_TMEM53

Family

9,134

false

This signature identifies Transmembrane protein 53, that have no known function but are predicted to be integral membrane proteins.

[]

0

[ "PFAM", "PANTHER" ]

[ "PF05705", "PTHR12265" ]

[ "DUF829", "" ]

[ 9062, 7349 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Mimiviridae", "seawater metagenome" ]

[ 10, 9121, 2, 1 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 16, 4, 7, 6, 6, 2, 3, 15, 7, 30 ]

10

true

Family

Protein of unknown function DUF829, TMEM53

DUF829_TMEM53

5

IPR008550

8,550

Herpesvirus tegument protein BRRF2-like

Herpesvirus_BRRF2-like

Family

186

false

This entry contains BRRF2 from Epstein-Barr virus. This protein family is restricted to the herpesviruses; it's function is not known. The protein is phosphorylated and is associated with the viral tegument [ ].

[]

0

[ "PFAM" ]

[ "PF05734" ]

[ "DUF832" ]

[ 186 ]

1

[]

0

[]

0

[ "PUB00054920" ]

[ "15534216" ]

[ "Proteins of purified Epstein-Barr virus." ]

[ 2004 ]

1

[]

0

null

[ "Orthoherpesviridae" ]

[ 186 ]

1

[]

0

true

Family

Herpesvirus tegument protein BRRF2-like

Herpesvirus_BRRF2-like

2

IPR008551

8,551

Transport and Golgi organisation protein 2

TANGO2

Family

12,396

false

In eukaryotes this family is predicted to play a role in protein secretion and Golgi organisation [ ]. In plants this family includes , which is involved in water permeability in the cuticles of fruit [ ]. has been found to be expressed during early embryogenesis in mice [ ]. This protein contains a conserved NRDE moti...

[]

0

[ "PFAM", "PANTHER" ]

[ "PF05742", "PTHR17985" ]

[ "TANGO2", "" ]

[ 12387, 11172 ]

2

[]

0

[ "8sv7", "9bwa", "9n1s" ]

3

[ "PUB00011316", "PUB00075420", "PUB00075421" ]

[ "8268909", "16452979", "17877702" ]

[ "Isolation of a gene expressed during early embryogenesis from the region of 22q11 commonly deleted in DiGeorge syndrome.", "Functional genomics reveals genes involved in protein secretion and Golgi organization.", "The identification of a gene (Cwp1), silenced during Solanum evolution, which causes cuticle mic...

[ 1993, 2006, 2007 ]

3

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Nucleocytoviricota", "unclassified sequences" ]

[ 330, 6231, 5755, 14, 66 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 28, 2, 2, 3, 13, 8, 1, 6, 8, 1, 20 ]

11

true

Family

Transport and Golgi organisation protein 2

TANGO2

8

IPR008552

8,552

Domain of unknown function DUF834

DUF834

Domain

505

false

This short presumed domain is found in a large number of hypothetical plant proteins. The domain is quite rich in conserved glycine residues. It occurs in some putative transposons but currently has no known function.

[]

0

[ "PFAM" ]

[ "PF05754" ]

[ "DUF834" ]

[ 505 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Oryzinae" ]

[ 505 ]

1

[ "Oryza sativa subsp. japonica" ]

[ 413 ]

1

true

Domain

Domain of unknown function DUF834

DUF834

1

IPR008553

8,553

Domain of unknown function DUF835

DUF835

Domain

501

false

The members of this archaebacterial protein entry are around 250-300 amino acid residues in length. The function of these proteins is not known.

[]

0

[ "PFAM" ]

[ "PF05763" ]

[ "DUF835" ]

[ 501 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria", "ecological metagenomes" ]

[ 492, 3, 6 ]

3

[]

0

true

Domain

Domain of unknown function DUF835

DUF835

9

IPR008555

8,555

SIKE family

SIKE

Family

3,216

false

Suppressor of IKBKE 1 (SIKE) is a physiological suppressor of IKK-epsilon and TBK1 [ ]. IKKepsilon and TBK1 are two IKK-related kinases critically involved in virus- and TLR3-triggered activation of interferon regulatory factor 3 (IRF-3). Other members of this family are circulating cathodic antigen (CCA), found in Sch...

[]

0

[ "PFAM", "PANTHER" ]

[ "PF05769", "PTHR12186" ]

[ "SIKE", "" ]

[ 3215, 2708 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-1839117", "R-HSA-5655302", "R-HSA-918233", "R-HSA-933541", "R-HSA-9692916", "R-HSA-9705671" ]

[ "REACTOME:R-HSA-1839117", "REACTOME:R-HSA-5655302", "REACTOME:R-HSA-918233", "REACTOME:R-HSA-933541", "REACTOME:R-HSA-9692916", "REACTOME:R-HSA-9705671" ]

6

[ "6akk", "6akl", "6akm" ]

3

[ "PUB00011317", "PUB00059261", "PUB00059262", "PUB00059263" ]

[ "10413050", "16281057", "14527947", "7925469" ]

[ "Molecular cloning and characterization of the polypeptide backbone of Schistosoma mansoni circulating cathodic antigen.", "SIKE is an IKK epsilon/TBK1-associated suppressor of TLR3- and virus-triggered IRF-3 activation pathways.", "Oral fibroblast expression of wound-inducible transcript 3.0 (wit3.0) accelerat...

[ 1999, 2005, 2003, 1994 ]

4

[]

0

null

[ "Bacteria", "Eukaryota" ]

[ 2, 3214 ]

2

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 3, 6, 3, 5, 11 ]

6

true

Family

SIKE family

SIKE

9

IPR008558

8,558

Minor capsid protein VP2, lagovirus

VP2_lagovirus

Family

269

false

This family includes minor capsid protein VP2 from Rabbit hemorrhagic disease virus and related lagoviruses. VP2 is a minor structural protein that forms a portal-like structure at a unique three-fold axis of symmetry, following binding to the host receptor. The channel formed by VP2 may allow the delivery of the viral...

[]

0

[ "PFAM" ]

[ "PF05801" ]

[ "VP2_lagovir" ]

[ 269 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Lagovirus" ]

[ 269 ]

1

[]

0

true

Family

Minor capsid protein VP2, lagovirus

VP2_lagovirus

5

IPR008559

8,559

Calcium load-activated calcium channel

TMCO1

Family

2,514

false

This entry includes TMCO1, a member of the Oxa1 superfamily which includes a group of proteins that function in different contexts as transmembrane domains (TMD) insertases and/or as intramembrane chaperones to facilitate membrane protein folding and assembly [ , ]. TMCO1 has been recently described as a component of t...

[ "GO:0005262", "GO:0032469", "GO:0005789" ]

[ "calcium channel activity", "endoplasmic reticulum calcium ion homeostasis", "endoplasmic reticulum membrane" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PIRSF", "PANTHER" ]

[ "PIRSF023322", "PTHR20917" ]

[ "DUF841_euk", "" ]

[ 1816, 2514 ]

2

[]

0

[ "6w6l", "7tut" ]

2

[ "PUB00081416", "PUB00086930", "PUB00097241", "PUB00103609", "PUB00151274", "PUB00151275" ]

[ "27212239", "26256539", "32820719", "36261522", "29281821", "35927240" ]

[ "TMCO1 Is an ER Ca(2+) Load-Activated Ca(2+) Channel.", "A YidC-like Protein in the Archaeal Plasma Membrane.", "An ER translocon for multi-pass membrane protein biogenesis.", "Substrate-driven assembly of a translocon for multipass membrane proteins.", "Identification of Oxa1 Homologs Operating in the Euka...

[ 2016, 2015, 2020, 2022, 2017, 2022 ]

6

[ "IPR002809" ]

[]

1

0

1

[ "Eukaryota" ]

[ 2514 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 7, 1, 1, 2, 6, 3, 2, 5, 7 ]

9

true

Family

Calcium load-activated calcium channel

TMCO1

1

IPR008560

8,560

Protein of unknown function DUF842, eukaryotic

DUF842_euk

Family

2,561

false

This family represents Protein FAM136A and similar uncharacterised proteins of unknown function from animals and plants. The sequences carry three sets of CxxxC motifs, which might suggest a type of zinc-finger formation. In humans, FAM136A has been related to Meniere's disease, a complex disorder of the inner ear [ , ...

[]

0

[ "PFAM", "PANTHER" ]

[ "PF05811", "PTHR21096" ]

[ "DUF842", "" ]

[ 2560, 2412 ]

2

[]

0

[]

0

[ "PUB00099942", "PUB00099943" ]

[ "31874721", "33136635" ]

[ "Genetic architecture of Meniere's disease.", "Burden of Rare Variants in the OTOG Gene in Familial Meniere's Disease." ]

[ 2020, 2020 ]

2

[]

0

null

[ "Eukaryota", "Pseudoxanthomonas suwonensis" ]

[ 2560, 1 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 19, 1, 1, 3, 4, 2, 2, 3, 9 ]

9

true

Family

Protein of unknown function DUF842, eukaryotic

DUF842_euk

6

IPR008561

8,561

Protein Ac76, baculovirus

Ac76_baculovir

Family

141

false

This family consists mainly of baculovirus proteins. The member from Autographa californica multiple nucleopolyhedrovirus (AcMNPV), protein Ac76, has been characterised, and is involved in intranuclear microvesicle formation [ ].

[]

0

[ "PFAM" ]

[ "PF05814" ]

[ "Ac76" ]

[ 141 ]

1

[]

0

[]

0

[ "PUB00082598" ]

[ "20484514" ]

[ "Autographa californica multiple nucleopolyhedrovirus ac76 is involved in intranuclear microvesicle formation." ]

[ 2010 ]

1

[]

0

null

[ "Bacteria", "Baculoviridae", "Eumetazoa", "marine sediment metagenome" ]

[ 25, 112, 3, 1 ]

4

[]

0

true

Family

Protein Ac76, baculovirus

Ac76_baculovir

3

IPR008562

8,562

Autographa californica nuclear polyhedrosis virus (AcMNPV), C42

AcMNPV_C42

Family

151

false

This entry is represented by Autographa californica nuclear polyhedrosis virus (AcMNPV), Orf101 (also known as Protein C42) [ ]. It plays a role in host nuclear actin polymerization by recruiting p78/73 protein that is capable of activating an actin-related protein 2/3 complex to initiate nuclear actin polymerization [...

[]

0

[ "PFAM" ]

[ "PF05815" ]

[ "AcMNPV_Orf101" ]

[ 151 ]

1

[]

0

[ "8i8b", "8i8c", "8vwi", "8vwj", "9h2a", "9h2b", "9h2c", "9h2h", "9h2j", "9h2k" ]

10

[ "PUB00097485" ]

[ "20484515" ]

[ "The putative pocket protein binding site of Autographa californica nucleopolyhedrovirus BV/ODV-C42 is required for virus-induced nuclear actin polymerization." ]

[ 2010 ]

1

[]

0

null

[ "Baculoviridae" ]

[ 151 ]

1

[]

0

true

Family

Autographa californica nuclear polyhedrosis virus (AcMNPV), C42

AcMNPV_C42

4

IPR008563

8,563

Protein AC81, baculovirus

AcMNPV_AC81

Family

181

false

This family consists of Baculovirus proteins and includes Autographa californica multiple nucleopolyhedrovirus (AcMNPV) protein AC81, which is required for nucleocapsid envelopment [ ].

[]

0

[ "PFAM" ]

[ "PF05820" ]

[ "Ac81" ]

[ 181 ]

1

[]

0

[]

0

[ "PUB00082599" ]

[ "27212683" ]

[ "Autographa californica multiple nucleopolyhedrovirus gene ac81 is required for nucleocapsid envelopment." ]

[ 2016 ]

1

[]

0

null

[ "Venturia canescens", "Viruses" ]

[ 6, 175 ]

2

[]

0

true

Family

Protein AC81, baculovirus

AcMNPV_AC81

2

IPR008564

8,564

Golgi apparatus membrane protein TVP23-like

TVP23-like

Family

6,241

false

Tvp23 is a Golgi membrane protein involved in vesicular trafficking [ ].

[ "GO:0016020" ]

[ "membrane" ]

[ "cellular_component" ]

1

[ "PFAM", "PANTHER" ]

[ "PF05832", "PTHR13019" ]

[ "DUF846", "" ]

[ 6232, 6081 ]

2

[]

0

[]

0

[ "PUB00086476" ]

[ "21512130" ]

[ "Conserved Arabidopsis ECHIDNA protein mediates trans-Golgi-network trafficking and cell elongation." ]

[ 2011 ]

1

[]

0

null

[ "Bacteria", "Eukaryota" ]

[ 2, 6239 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 4, 1, 2, 5, 15, 2, 2, 5, 8, 1, 1, 7 ]

12

true

Family

Golgi apparatus membrane protein TVP23-like

TVP23-like

6

IPR008565

8,565

TtsA-like, Glycoside hydrolase family 108 domain

TtsA-like_GH18_dom

Domain

5,043

false

This entry represents a domain that is frequently found at the N terminus of proteins containing a C-terminal domain, predominantly in bacteria and virus, including Glycoside hydrolase family 108 protein from Salmonella typhi (TtsA, ). TtsA is a specific muramidase that facilitates toxin transport through the peptidogl...

[]

0

[ "PFAM" ]

[ "PF05838" ]

[ "Glyco_hydro_108" ]

[ 5043 ]

1

[]

0

[ "2ikb", "2is5", "2nr7", "6v3z", "6v40", "7dnp" ]

6

[ "PUB00101029", "PUB00101030" ]

[ "23174673", "31958059" ]

[ "A Salmonella Typhi homologue of bacteriophage muramidases controls typhoid toxin secretion.", "Mechanisms of substrate recognition by a typhoid toxin secretion-associated muramidase." ]

[ 2013, 2020 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "Viruses", "metagenomes" ]

[ 4572, 43, 343, 85 ]

4

[]

0

true

Domain

TtsA-like, Glycoside hydrolase family 108 domain

TtsA-like_GH18_dom

3

IPR008567

8,567

Beta-keto acid cleavage enzyme

BKACE

Family

14,556

false

This family represents a group of beta-keto acid cleavage enzymes (BKACE) mainly found in prokaryotes that show at least 14 slightly different potential enzymatic activities [ ]. In certain instances these enzymes catalyse the conversion of 3-keto-5-aminohexanoate and acetyl-CoA into acetoacetate and 3-aminobutyryl-CoA...

[ "GO:0043720" ]

[ "3-keto-5-aminohexanoate cleavage activity" ]

[ "molecular_function" ]

1

[ "PFAM", "PANTHER" ]

[ "PF05853", "PTHR37418" ]

[ "BKACE", "" ]

[ 14535, 14344 ]

2

[]

0

[ "2y7d", "2y7e", "2y7f", "2y7g", "3c6c", "3chv", "3e02", "3e49", "3fa5", "3lot", "3no5", "4nna", "4nnb", "4nnc", "5iky", "5ikz", "5zmu", "5zmy", "8rio", "8rip", "9hnf" ]

21

[ "PUB00056558", "PUB00060546", "PUB00060547", "PUB00103502" ]

[ "21632536", "6811551", "17166837", "24240508" ]

[ "3-Keto-5-aminohexanoate cleavage enzyme: a common fold for an uncommon Claisen-type condensation.", "Pathway of lysine degradation in Fusobacterium nucleatum.", "Identification of the last unknown genes in the fermentation pathway of lysine.", "Revealing the hidden functional diversity of an enzyme family." ...

[ 2011, 1982, 2007, 2014 ]

4

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Klosneuvirus KNV1", "unclassified sequences" ]

[ 240, 13979, 42, 1, 294 ]

5

[]

0

true

Family

Beta-keto acid cleavage enzyme

BKACE

2

IPR008568

8,568

ER membrane protein complex subunit 3

EMC3

Family

4,959

false

EMC3 is a subunit if the ER Membrane protein Complex (EMC), which is required for efficient folding of proteins in the endoplasmic reticulum (ER). Loss of the EMC leads to accumulation of misfolded membrane proteins [ ].

[ "GO:0016020" ]

[ "membrane" ]

[ "cellular_component" ]

1

[ "PIRSF", "PANTHER" ]

[ "PIRSF010045", "PTHR13116" ]

[ "DUF850_TM_euk", "" ]

[ 3972, 4959 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-8980692", "R-HSA-8980692", "R-MMU-8980692", "R-RNO-8980692" ]

[ "REACTOME:R-BTA-8980692", "REACTOME:R-HSA-8980692", "REACTOME:R-MMU-8980692", "REACTOME:R-RNO-8980692" ]

4

[ "6wb9", "6ww7", "6z3w", "7ado", "7adp", "7kra", "7ktx", "8eoi", "8j0n", "8j0o", "8s9s", "9c7v" ]

12

[ "PUB00061987" ]

[ "19325107" ]

[ "Comprehensive characterization of genes required for protein folding in the endoplasmic reticulum." ]

[ 2009 ]

1

[ "IPR002809" ]

[]

1

0

1

[ "Eukaryota" ]

[ 4959 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 2, 1, 3, 1, 5, 1, 1, 3, 4, 1, 1, 4 ]

12

true

Family

ER membrane protein complex subunit 3

EMC3

4

IPR008569

8,569

Protein of unknown function DUF851

DUF851

Family

268

false

Proteins in this family have no known function and only seem to occur in Chromadorea.

[]

0

[ "PFAM" ]

[ "PF05867" ]

[ "DUF851" ]

[ 268 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Rhabditida" ]

[ 268 ]

1

[ "Caenorhabditis elegans" ]

[ 6 ]

1

true

Family

Protein of unknown function DUF851

DUF851

2

IPR008570

8,570

ESCRT-II complex, Vps25 subunit

ESCRT-II_cplx_Vps25-sub

Family

4,342

false

This entry represents the Vps25 subunit (vacuolar protein sorting-associated protein 25) of the endosome-associated complex ESCRT-II (Endosomal Sorting Complexes Required for Transport protein II). ESCRT (ESCRT-I, -II, -III) complexes orchestrate efficient sorting of ubiquitinated transmembrane receptors to lysosomes v...

[ "GO:0071985", "GO:0000814" ]

[ "multivesicular body sorting pathway", "ESCRT II complex" ]

[ "biological_process", "cellular_component" ]

2

[ "PFAM", "PANTHER" ]

[ "PF05871", "PTHR13149" ]

[ "ESCRT-II", "" ]

[ 4323, 4153 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-917729", "R-DDI-917729", "R-DME-917729", "R-DRE-917729", "R-HSA-917729", "R-HSA-9610379", "R-MMU-917729", "R-RNO-917729", "R-SCE-917729", "R-SPO-917729" ]

[ "REACTOME:R-BTA-917729", "REACTOME:R-DDI-917729", "REACTOME:R-DME-917729", "REACTOME:R-DRE-917729", "REACTOME:R-HSA-917729", "REACTOME:R-HSA-9610379", "REACTOME:R-MMU-917729", "REACTOME:R-RNO-917729", "REACTOME:R-SCE-917729", "REACTOME:R-SPO-917729" ]

10

[ "1u5t", "1w7p", "1xb4", "2zme", "3cuq", "3htu", "7pb9" ]

7

[ "PUB00019520", "PUB00019521", "PUB00032375", "PUB00035959" ]

[ "12194858", "15469844", "15579210", "17215868" ]

[ "Endosome-associated complex, ESCRT-II, recruits transport machinery for protein sorting at the multivesicular body.", "ESCRT-II, an endosome-associated complex required for protein sorting: crystal structure and interactions with ESCRT-III and membranes.", "Crystal structure of subunit VPS25 of the endosomal t...

[ 2002, 2004, 2004, 2007 ]

4

[]

0

null

[ "Eukaryota", "Promethearchaeati", "unclassified sequences" ]

[ 4323, 6, 13 ]

3

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 2, 1, 2, 1, 4, 5, 1, 4, 8, 1, 1, 13 ]

12

true

Family

ESCRT-II complex, Vps25 subunit

ESCRT-II_cplx_Vps25-sub

8

IPR008573

8,573

Baculovirus U-box/Ring-like

Baculovirus_U-box/Ring-like

Family

131

false

This family consists of several Baculovirus proteins of around 130 residues in length. The function of members of this family is unknown, but appear to be related to the U-box and ring finger domain by profile-profile comparison. In the Autographa californica multiple nucleopolyhedrovirus, ac53 (also known as orf53) is...

[]

0

[ "PFAM" ]

[ "PF05883" ]

[ "Baculo_RING" ]

[ 131 ]

1

[]

0

[]

0

[ "PUB00082615" ]

[ "18851866" ]

[ "Autographa californica multiple nucleopolyhedrovirus ac53 plays a role in nucleocapsid assembly." ]

[ 2008 ]

1

[]

0

null

[ "Baculoviridae" ]

[ 131 ]

1

[]

0

true

Family

Baculovirus U-box/Ring-like

Baculovirus_U-box/Ring-like

1

IPR008574

8,574

Interactor of ZYG-11, nematodes

Nematodes_ZYG-11_interact

Family

309

false

This entry represents the protein product of the gene W03D8.9 ( ) and similar sequences from nematodes. This protein has been identified as an interactor of ZYG-11. ZYG-11 is the substrate-recognition subunit for a CUL-2 based complex that regulates cell division and embryonic development [ ].

[]

0

[ "PFAM", "PIRSF" ]

[ "PF05884", "PIRSF016383" ]

[ "ZYG-11_interact", "DUF856_CAE_spp" ]

[ 309, 30 ]

2

[]

0

[]

0

[ "PUB00090865" ]

[ "17304241" ]

[ "The Caenorhabditis elegans cell-cycle regulator ZYG-11 defines a conserved family of CUL-2 complex components." ]

[ 2007 ]

1

[]

0

null

[ "Nematoda" ]

[ 309 ]

1

[ "Caenorhabditis elegans" ]

[ 6 ]

1

true

Family

Interactor of ZYG-11, nematodes

Nematodes_ZYG-11_interact

6

IPR008577

8,577

Putative viral structural protein (DUF859)

DUF859

Family

622

false

This family consists of several uncharacterised proteins from a number of the Siphoviruses as well as some bacterial proteins from Streptococcus species. Some of the members of this family are described as putative minor structural proteins.

[]

0

[ "PFAM" ]

[ "PF05895" ]

[ "DUF859" ]

[ 622 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Viruses", "metagenomes" ]

[ 364, 2, 254, 2 ]

4

[]

0

true

Family

Putative viral structural protein (DUF859)

DUF859

9

IPR008579

8,579

(S)-ureidoglycine aminohydrolase, cupin domain

UGlyAH_Cupin_dom

Domain

15,519

false

This is the conserved barrel domain of the 'cupin' superfamily found in (S)-ureidoglycine aminohydrolase (UGlyAH or UGHY) from E.coli, with a conserved jelly roll-like β-barrel fold capable of homodimerization. This enzyme is involved in the anaerobic nitrogen utilization via the assimilation of allantoin and catalyses...

[]

0

[ "PFAM" ]

[ "PF05899" ]

[ "Cupin_3" ]

[ 15519 ]

1

[]

0

[ "1lkn", "1o5u", "1rc6", "1sef", "1sfn", "2k9z", "3bcw", "3es4", "3myx", "8qma", "8r5o", "8r6s", "8ras", "8rdj", "8w9z", "8wa0", "8wa1", "8xzv", "9epc" ]

19

[ "PUB00063996", "PUB00078751", "PUB00096858", "PUB00096913" ]

[ "23144756", "19935661", "20038185", "26448059" ]

[ "Structural insight into the Clostridium difficile ethanolamine utilisation microcompartment.", "Ureide catabolism in Arabidopsis thaliana and Escherichia coli.", "Chemical basis of nitrogen recovery through the ureide pathway: formation and hydrolysis of S-ureidoglycine in plants and bacteria.", "The EutQ an...

[ 2012, 2010, 2010, 2016 ]

4

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 14, 11891, 3457, 157 ]

4

[ "Arabidopsis thaliana", "Escherichia coli (strain K12)", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 24, 1, 14, 19 ]

4

true

Domain

(S)-ureidoglycine aminohydrolase, cupin domain

UGlyAH_Cupin_dom

6

IPR008580

8,580

PPPDE peptidase domain

PPPDE_dom

Domain

16,251

false

The PPPDE superfamily (after Permuted Papain fold Peptidases of DsRNA viruses and Eukaryotes), consists of thiol peptidases with a circularly permuted papain-like fold. They contain a PPPDE domain which is a cysteine isopeptidase that exhibits a deSUMOylase activity in PPPDE2 (DeSI-1) and a deubiquinating activity in P...

[ "GO:0008233" ]

[ "peptidase activity" ]

[ "molecular_function" ]

1

[ "PFAM", "PROFILE", "PANTHER", "SMART" ]

[ "PF05903", "PS51858", "PTHR12378", "SM01179" ]

[ "Peptidase_C97", "PPPDE", "", "DUF862" ]

[ 15975, 16000, 15242, 15542 ]

4

[]

0

[ "2wp7", "3ebq", "7whm", "7whn" ]

4

[ "PUB00020916", "PUB00092827", "PUB00094801" ]

[ "15483401", "22498933", "28483520" ]

[ "Novel predicted peptidases with a potential role in the ubiquitin signaling pathway.", "Crystal structure of DeSI-1, a novel deSUMOylase belonging to a putative isopeptidase superfamily.", "PPPDE1 is a novel deubiquitinase belonging to a cysteine isopeptidase family." ]

[ 2004, 2012, 2017 ]

3

[]

0

null

[ "Bacteria", "Eukaryota", "Viruses", "metagenomes" ]

[ 6, 16195, 46, 4 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Schizosaccharomyces pombe (stra...

[ 39, 1, 11, 2, 3, 8, 3, 31, 14, 1, 64 ]

11

true

Domain

PPPDE peptidase domain

PPPDE_dom

6

IPR008581

8,581

Protein of unknown function DUF863, plant

DUF863_pln

Family

2,671

false

This family consists of a number of hypothetical proteins from plants. The function of this family is unknown.

[]

0

[ "PFAM" ]

[ "PF05904" ]

[ "DUF863" ]

[ 2671 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Tracheophyta", "Vibrio vulnificus" ]

[ 2670, 1 ]

2

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 28, 8, 29 ]

3

true

Family

Protein of unknown function DUF863, plant

DUF863_pln

8

IPR008585

8,585

Poly-gamma-glutamate hydrolase

Gamma_PGA_hydro

Family

1,673

false

This family consists of a number of bacterial and phage proteins that function as gamma-PGA hydrolase enzymes [ ]. Structurally the protein in this family adopted an open α/β mixed core structure with a seven-stranded parallel/anti-parallel β-sheet. This structure shows similarity to mammalian carboxypeptidase A and re...

[]

0

[ "PFAM" ]

[ "PF05908" ]

[ "Gamma_PGA_hydro" ]

[ 1673 ]

1

[]

0

[ "3a9l", "5onj", "5onk", "5onl", "6hri", "6hrj" ]

6

[ "PUB00078732" ]

[ "26158264" ]

[ "γ-PGA Hydrolases of Phage Origin in Bacillus subtilis and Other Microbial Genomes." ]

[ 2015 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "Halobacteriales", "Viruses", "ecological metagenomes" ]

[ 1498, 12, 74, 47, 42 ]

5

[]

0

true

Family

Poly-gamma-glutamate hydrolase

Gamma_PGA_hydro

5

IPR008586

8,586

Protein of unknown function DUF868, plant

DUF868_pln

Family

6,204

false

This family consists of several hypothetical proteins from plants. The function of this family is unknown.

[]

0

[ "PFAM", "PANTHER" ]

[ "PF05910", "PTHR31972" ]

[ "DUF868", "" ]

[ 6202, 6032 ]

2

[]

0

[]

0

[ "PUB00163241", "PUB00163242" ]

[ "2913346", "29133465" ]

[ "The management of chronic interstitial cystitis by substitution cystoplasty.", "CORTICAL MICROTUBULE DISORDERING1 Is Required for Secondary Cell Wall Patterning in Xylem Vessels." ]

[ 1989, 2017 ]

2

[]

0

null

[ "Embryophyta" ]

[ 6204 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 40, 44, 49 ]

3

true

Family

Protein of unknown function DUF868, plant

DUF868_pln

1

IPR008587

8,587

Filament-like plant protein

FPP_plant

Family

5,043

false

This entry represents the filament-like plant proteins. In Arabidopsis thaliana, there are 7 filament-like plant proteins. They are coiled-coil proteins with unknown function [ ].

[]

0

[ "PFAM" ]

[ "PF05911" ]

[ "FPP" ]

[ 5043 ]

1

[]

0

[]

0

[ "PUB00066863" ]

[ "11972898" ]

[ "Four signature motifs define the first class of structurally related large coiled-coil proteins in plants." ]

[ 2002 ]

1

[]

0

null

[ "Embryophyta" ]

[ 5043 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 44, 29, 65 ]

3

true

Family

Filament-like plant protein

FPP_plant

5

IPR008588

8,588

Protein of unknown function DUF870, Caenorhabditis species

DUF870_CAE_spp

Family

331

false

This family consists of proteins of unknown function found in Caenorhabditis species.

[]

0

[ "PFAM" ]

[ "PF05912" ]

[ "DUF870" ]

[ 331 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Caenorhabditis" ]

[ 331 ]

1

[ "Caenorhabditis elegans" ]

[ 18 ]

1

true

Family

Protein of unknown function DUF870, Caenorhabditis species

DUF870_CAE_spp

7

IPR008589

8,589

6-phospho-N-acetylmuramidase

MupG

Family

4,003

false

This family consists of 6-phospho-N-acetylmuramidase, involved in the recycling pathway of the cell wall turnover product MurNAc-GlcNAc in S.aureus. It catalyses the hydrolysis of MurNAc 6-phosphate-GlcNAc, the disaccharide product of MurP-uptake and phosphorylation, yielding MurNAc 6-phosphate and GlcNAc [ ].

[]

0

[ "PANTHER" ]

[ "PTHR38435" ]

[ "" ]

[ 4003 ]

1

[]

0

[ "1x7f", "2p0o" ]

2

[ "PUB00097906" ]

[ "30524387" ]

[ "Recovery of the Peptidoglycan Turnover Product Released by the Autolysin Atl in <i>Staphylococcus aureus</i> Involves the Phosphotransferase System Transporter MurP and the Novel 6-phospho-<i>N</i>-acetylmuramidase MupG." ]

[ 2018 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Opisthokonta", "metagenomes" ]

[ 39, 3949, 2, 13 ]

4

[]

0

true

Family

6-phospho-N-acetylmuramidase

MupG

6

IPR008590

8,590

Transmembrane protein 230/134

TMEM_230/134

Family

4,365

false

This entry represents the eukaryotic transmembrane proteins 230 and 134 (TMEM230 and 134). TMEM134 function is unknown, but it has been shown to interact with E virus ORF2 [ ]. TMEM 230 is involved in trafficking and recycling of synaptic vesicles [ ].

[]

0

[ "PFAM" ]

[ "PF05915" ]

[ "TMEM_230_134" ]

[ 4365 ]

1

[]

0

[]

0

[ "PUB00090009", "PUB00095530" ]

[ "27899274", "27270108" ]

[ "Systematic identification of hepatitis E virus ORF2 interactome reveals that TMEM134 engages in ORF2-mediated NF-κB pathway.", "Identification of TMEM230 mutations in familial Parkinson's disease." ]

[ 2017, 2016 ]

2

[]

[ "IPR039714", "IPR044234" ]

0

2

0

[ "Eukaryota" ]

[ 4365 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 8, 1, 5, 2, 5, 5, 10, 9, 11 ]

9

true

Family

Transmembrane protein 230/134

TMEM_230/134

7

IPR008591

8,591

GINS complex subunit Sld5

GINS_Sld5

Family

4,186

false

GINS is a key component of eukaryotic replicative forks. It is part of the CMG (Cdc45-MCM-GINS) complex, the eukaryotic replicative helicase that unwinds double-stranded DNA at replication forks [ ]. Beside its role as a key component of the CMG complex, GINS mediates a interactions with many replication factors [ , ]....

[ "GO:0006261" ]

[ "DNA-templated DNA replication" ]

[ "biological_process" ]

1

[ "PIRSF", "PANTHER" ]

[ "PIRSF007764", "PTHR21206" ]

[ "Sld5", "" ]

[ 3466, 4176 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-176974", "R-DDI-176974", "R-HSA-176974", "R-MMU-176974", "R-RNO-176974", "R-SCE-176974", "R-SPO-176974" ]

[ "REACTOME:R-BTA-176974", "REACTOME:R-DDI-176974", "REACTOME:R-HSA-176974", "REACTOME:R-MMU-176974", "REACTOME:R-RNO-176974", "REACTOME:R-SCE-176974", "REACTOME:R-SPO-176974" ]

7

[ "2e9x", "2eho", "2q9q", "3jc5", "3jc6", "3jc7", "5u8s", "5u8t", "6hv9", "6ptj", "6ptn", "6pto", "6raw", "6rax", "6ray", "6raz", "6skl", "6u0m", "6xtx", "6xty", "7pfo", "7plo", "7pmk", "7pmn", "7qhs", "7z13", "8b9a", "8b9b", "8b9c", "8b9d", "8kg6", "8kg8"...

46

[ "PUB00085132", "PUB00085133", "PUB00085134", "PUB00085135" ]

[ "23412083", "22918584", "20070258", "28071757" ]

[ "Structure and evolutionary origins of the CMG complex.", "The GINS complex: structure and function.", "Structure and function of the GINS complex, a key component of the eukaryotic replisome.", "New insights into the GINS complex explain the controversy between existing structural models." ]

[ 2013, 2012, 2010, 2017 ]

4

[]

0

null

[ "Eukaryota" ]

[ 4186 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 4, 2, 3, 2, 4, 1, 1, 2, 6, 1, 1, 10 ]

12

true

Family

GINS complex subunit Sld5

GINS_Sld5

7

IPR008592

8,592

Protein of unknown function DUF874

DUF874

Family

319

false

This family consists of several hypothetical proteins, mainly from Helicobacter pylori. The function of this family is unknown.

[]

0

[ "PFAM", "PIRSF" ]

[ "PF05917", "PIRSF015868" ]

[ "DUF874", "DUF874_HELPY" ]

[ 319, 148 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota" ]

[ 308, 11 ]

2

[]

0

true

Family

Protein of unknown function DUF874

DUF874

9

IPR008593

8,593

DNA N-6-adenine-methyltransferase

Dam_MeTrfase

Family

3,672

false

This family consists of several bacterial and phage DNA N-6-adenine-methyltransferase (Dam) like sequences [ ]. Dam methylates adenine residues in the ssDNA and dsDNA sequence 5'-GATC-3' [ ].

[ "GO:0003677", "GO:0009007", "GO:0009307" ]

[ "DNA binding", "site-specific DNA-methyltransferase (adenine-specific) activity", "DNA restriction-modification system" ]

[ "molecular_function", "molecular_function", "biological_process" ]

3

[ "PFAM", "NCBIFAM" ]

[ "PF05869", "TIGR01712" ]

[ "Dam", "phage_N6A_met" ]

[ 3672, 1748 ]

2

[]

0

[]

0

[ "PUB00011318", "PUB00100309" ]

[ "2180941", "10581668" ]

[ "Primary structure of a DNA (N6-adenine)-methyltransferase from Escherichia coli virus T1. DNA sequence, genomic organization, and comparative analysis.", "Cloning of the Dam methyltransferase gene from Haemophilus influenzae bacteriophage HP1." ]

[ 1990, 1999 ]

2

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 36, 2407, 476, 610, 143 ]

5

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

DNA N-6-adenine-methyltransferase

Dam_MeTrfase

7

IPR008594

8,594

Scavenger mRNA decapping enzyme DcpS/DCS2

DcpS/DCS2

Family

3,847

false

This entry represents scavenger mRNA decapping enzymes, such as Dcp2 and DcpS. DcpS is a scavenger pyrophosphatase that hydrolyses the residual cap structure following 3' to 5' mRNA degradation. DcpS uses cap dinucleotides or capped oligonucleotides as substrate to release m(7)GMP (N7-methyl GMP), while Dcp2 uses cappe...

[ "GO:0016787", "GO:0000290" ]

[ "hydrolase activity", "deadenylation-dependent decapping of nuclear-transcribed mRNA" ]

[ "molecular_function", "biological_process" ]

2

[ "PFAM", "PIRSF", "PANTHER" ]

[ "PF05652", "PIRSF028973", "PTHR12978" ]

[ "DcpS", "Scavenger_mRNA_decap_enz", "" ]

[ 3216, 2734, 3771 ]

3

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "3.6.1.59", "R-CEL-429958", "R-HSA-429958", "R-MMU-429958", "R-RNO-429958", "R-SCE-429958", "R-SPO-429958", "R-SSC-429958" ]

[ "EC:3.6.1.59", "REACTOME:R-CEL-429958", "REACTOME:R-HSA-429958", "REACTOME:R-MMU-429958", "REACTOME:R-RNO-429958", "REACTOME:R-SCE-429958", "REACTOME:R-SPO-429958", "REACTOME:R-SSC-429958" ]

8

[ "1st0", "1st4", "1vlr", "1xml", "1xmm", "3bl7", "3bl9", "3bla", "4qde", "4qdv", "4qeb", "5bv3", "5osy", "6gbs", "6trq" ]

15

[ "PUB00035577", "PUB00035578" ]

[ "16246173", "16001405" ]

[ "Decapping the message: a beginning or an end.", "Crystal structure of an Apo mRNA decapping enzyme (DcpS) from Mouse at 1.83 A resolution." ]

[ 2006, 2005 ]

2

[]

0

null

[ "Eukaryota", "Klosneuvirinae", "metagenomes" ]

[ 3827, 11, 9 ]

3

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strai...

[ 2, 1, 1, 4, 3, 1, 5, 2, 1 ]

9

true

Family

Scavenger mRNA decapping enzyme DcpS/DCS2

DcpS/DCS2

6

IPR008596

8,596

Accessory protein p30II

P30II

Family

123

false

Human T-cell leukemia/lymphoma virus type 1 (HTLV-1)-encoded P30II is a nuclear-resident protein that inhibits virus expression by reducing Tax and Rex protein expression [ ].

[]

0

[ "PFAM" ]

[ "PF05599" ]

[ "Deltaretro_Tax" ]

[ 123 ]

1

[]

0

[]

0

[ "PUB00077042" ]

[ "14730358" ]

[ "HTLV-1-encoded p30II is a post-transcriptional negative regulator of viral replication." ]

[ 2004 ]

1

[]

0

null

[ "Deltaretrovirus" ]

[ 123 ]

1

[]

0

true

Family

Accessory protein p30II

P30II

3

IPR008597

8,597

Invertebrate-type lysozyme

Invert_lysozyme

Family

1,814

false

This is a family of invertebrate-type lysozymes [ ]. It includes Destabilase ( ), an endo-epsilon(gamma-Glu)-Lys isopeptidase, which cleaves isopeptide bonds formed by transglutaminase (Factor XIIIa) between glutamine gamma-carboxamide and the ε-amino group of lysine [ ].

[ "GO:0003796" ]

[ "lysozyme activity" ]

[ "molecular_function" ]

1

[ "PFAM", "PROFILE", "PANTHER", "CDD" ]

[ "PF05497", "PS51909", "PTHR11195", "cd16890" ]

[ "Destabilase", "LYSOZYME_I", "", "lyz_i" ]

[ 1717, 1775, 1556, 1183 ]

4

[ "EC" ]

[ "3.2.1.17" ]

[ "EC:3.2.1.17" ]

1

[ "2dqa", "3ab6", "3ayq", "4pj2", "8bbu", "8bbw" ]

6

[ "PUB00011320", "PUB00085653" ]

[ "9003282", "24200802" ]

[ "Genes from the medicinal leech (Hirudo medicinalis) coding for unusual enzymes that specifically cleave endo-epsilon (gamma-Glu)-Lys isopeptide bonds and help to dissolve blood clots.", "The complete amino acid sequence and enzymatic properties of an i-type lysozyme isolated from the common orient clam (Meretrix...

[ 1996, 2013 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "marine sediment metagenome", "uncultured Caudovirales phage" ]

[ 5, 1805, 3, 1 ]

4

[ "Caenorhabditis elegans", "Drosophila melanogaster" ]

[ 7, 11 ]

2

true

Family

Invertebrate-type lysozyme

Invert_lysozyme

7

IPR008598

8,598

Di19, zinc-binding domain

Di19_Zn-bd

Domain

13,485

false

This zinc-binding domain is found in Di19 proteins, animal E3 ubiquitin-protein ligases (RNF114/KCMF1/RNF138/RNF125/RNF166) and transcriptional repressors (ZEB1/ZEB2). KCMF1 and RNF114 are E3 ubiquitin-protein ligases [ , ], while ZEB1 represses transcription by binding to the E box (5'-CANNTG-3') [ ]. In RNF114, this ...

[]

0

[ "PFAM" ]

[ "PF05605" ]

[ "zf-Di19" ]

[ 13485 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-983168", "R-CEL-6798695", "R-DME-6798695", "R-DRE-6798695", "R-HSA-6785807", "R-HSA-6798695", "R-HSA-936440", "R-HSA-9762293", "R-HSA-9764725", "R-HSA-9764790", "R-HSA-9823739", "R-HSA-983168", "R-HSA-9832991", "R-HSA-9926550", "R-MMU-6798695", "R-MMU-9762293", "R-MMU-9764725"...

[ "REACTOME:R-BTA-983168", "REACTOME:R-CEL-6798695", "REACTOME:R-DME-6798695", "REACTOME:R-DRE-6798695", "REACTOME:R-HSA-6785807", "REACTOME:R-HSA-6798695", "REACTOME:R-HSA-936440", "REACTOME:R-HSA-9762293", "REACTOME:R-HSA-9764725", "REACTOME:R-HSA-9764790", "REACTOME:R-HSA-9823739", "REACTOME:...

21

[ "2drp", "2mdg", "5dka", "9d9z", "9jni", "9nwe", "9qt9", "9qws", "9qwu", "9qwz", "9qx0", "9qx1", "9upz" ]

13

[ "PUB00011321", "PUB00067416", "PUB00075387", "PUB00075388", "PUB00075389", "PUB00078512", "PUB00151095" ]

[ "7823904", "19895399", "15581609", "23645206", "19935649", "16438971", "37116497" ]

[ "Abscisic acid-dependent and -independent regulation of gene expression by progressive drought in Arabidopsis thaliana.", "Functional analysis of TaDi19A, a salt-responsive gene in wheat.", "FIGC, a novel FGF-induced ubiquitin-protein ligase in gastric cancers.", "ZNF313 is a novel cell cycle activator with a...

[ 1995, 2010, 2004, 2013, 2009, 2006, 2023 ]

7

[]

0

null

[ "Bacteria", "Eukaryota", "Thermoprotei", "Viruses", "marine sediment metagenome" ]

[ 3, 13462, 12, 3, 5 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 32, 2, 37, 6, 35, 22, 14, 33, 59 ]

9

true

Domain

Di19, zinc-binding domain

Di19_Zn-bd

6

IPR008599

8,599

Putative sugar diacid recognition

Diacid_rec

Domain

5,673

false

This region is found in several proteins characterised as carbohydrate diacid regulators (e.g. ). An HTH DNA-binding motif is found at the C terminus of these proteins suggesting that this region includes the sugar recognition region.

[]

0

[ "PFAM" ]

[ "PF05651" ]

[ "Diacid_rec" ]

[ 5673 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 5647, 4, 22 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Domain

Putative sugar diacid recognition

Diacid_rec

4

IPR008601

8,601

Cell-cell adhesion

Dicty_CAD

Family

24

false

Most members of this group of proteins are found in Dictyostelium discoideum (Slime mould) and are essential in early development [ ]. and are located on the cell surface and mediate cell-cell adhesion.

[ "GO:0007155" ]

[ "cell adhesion" ]

[ "biological_process" ]

1

[ "PFAM" ]

[ "PF05720" ]

[ "Dicty_CAD" ]

[ 24 ]

1

[]

0

[]

0

[ "PUB00011322" ]

[ "2153977" ]

[ "A pair of tandemly repeated genes code for gp24, a putative adhesion protein of Dictyostelium discoideum." ]

[ 1990 ]

1

[]

0

null

[ "Dictyostelia", "Treponema phagedenis" ]

[ 23, 1 ]

2

[]

0

true

Family

Cell-cell adhesion

Dicty_CAD

8

IPR008602

8,602

Duffy-antigen binding domain

Duffy-antigen-binding

Domain

15,690

false

This entry contains several Plasmodium Duffy binding proteins. Plasmodium vivax and Plasmodium knowlesi merozoites invade Homo sapiens erythrocytes that express Duffy blood group surface determinants [ ]. The Duffy receptor family is localised in micronemes, an organelle found in all organisms of the phylum Apicomplexa...

[ "GO:0046789", "GO:0016020" ]

[ "host cell surface receptor binding", "membrane" ]

[ "molecular_function", "cellular_component" ]

2

[ "PFAM" ]

[ "PF05424" ]

[ "Duffy_binding" ]

[ 15690 ]

1

[ "REACTOME" ]

[ "R-HSA-202733" ]

[ "REACTOME:R-HSA-202733" ]

1

[ "1zrl", "1zro", "2wau", "2xu0", "2y8d", "2yk0", "3bqi", "3bqk", "3bql", "3cml", "3cpz", "3rrc", "3vuu", "3vuv", "4gf2", "4jno", "4k2u", "4nuu", "4nuv", "4p1t", "4qex", "4yfs", "5f3j", "5mza", "5x6n", "6oan", "6oao", "6r2s", "6s8t", "6s8u", "7b52", "7b54"...

55

[ "PUB00011323", "PUB00066893" ]

[ "2170017", "7689250" ]

[ "The Duffy receptor family of Plasmodium knowlesi is located within the micronemes of invasive malaria merozoites.", "A receptor for the malarial parasite Plasmodium vivax: the erythrocyte chemokine receptor." ]

[ 1990, 1993 ]

2

[]

0

null

[ "Plasmodium" ]

[ 15690 ]

1

[]

0

true

Domain

Duffy-antigen binding domain

Duffy-antigen-binding

3

IPR008603

8,603

Dynactin subunit 4

DCTN4

Family

4,006

false

DCTN4 (also known as dynactin subunit p62) is a subunit of the dynactin that may have a dual role in dynein targeting and in ACTR1A/Arp1 subunit of dynactin pointed-end capping. It could be involved in ACTR1A pointed-end binding and in additional roles in linking dynein and dynactin to the cortical cytoskeleton [ ]. It...

[ "GO:0005869" ]

[ "dynactin complex" ]

[ "cellular_component" ]

1

[ "PFAM", "PANTHER" ]

[ "PF05502", "PTHR13034" ]

[ "Dynactin_p62", "" ]

[ 3804, 3979 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-2132295", "R-HSA-3371497", "R-HSA-6807878", "R-HSA-6811436", "R-MMU-2132295", "R-MMU-3371497", "R-MMU-6807878", "R-MMU-6811436", "R-RNO-2132295", "R-RNO-3371497", "R-RNO-6807878", "R-RNO-6811436", "R-SSC-2132295", "R-SSC-3371497", "R-SSC-6807878" ]

[ "REACTOME:R-HSA-2132295", "REACTOME:R-HSA-3371497", "REACTOME:R-HSA-6807878", "REACTOME:R-HSA-6811436", "REACTOME:R-MMU-2132295", "REACTOME:R-MMU-3371497", "REACTOME:R-MMU-6807878", "REACTOME:R-MMU-6811436", "REACTOME:R-RNO-2132295", "REACTOME:R-RNO-3371497", "REACTOME:R-RNO-6807878", "REACTOM...

15

[ "6znl", "6znm", "6znn", "6zno", "6zo4", "7z8f", "7z8m", "8pr4", "8ptk", "9b7j", "9b85", "9dgr", "9dgs", "9dgt", "9dgu", "9dgv" ]

16

[ "PUB00011592", "PUB00071561" ]

[ "10607597", "16554302" ]

[ "Interaction of the p62 subunit of dynactin with Arp1 and the cortical actin cytoskeleton.", "Copper-dependent interaction of dynactin subunit p62 with the N terminus of ATP7B but not ATP7A." ]

[ 1999, 2006 ]

2

[]

0

null

[ "Eukaryota" ]

[ 4006 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus" ]

[ 1, 5, 1, 11, 4, 1, 7 ]

7

true

Family

Dynactin subunit 4

DCTN4

7

IPR008604

8,604

Microtubule-associated protein 7 family

MAP7_fam

Family

8,781

false

MAP7 (also known as E-MAP-115 or Ensconsin) is a microtubule-stabilising protein that may play an important role in microtubule reorganisation during polarisation and differentiation of epithelial cells [ ]. It may play a role in the formation of intercellular contacts [ , ]. The MAP7 family has three other members: MA...

[ "GO:0000226", "GO:0015630" ]

[ "microtubule cytoskeleton organization", "microtubule cytoskeleton" ]

[ "biological_process", "cellular_component" ]

2

[ "PFAM" ]

[ "PF05672" ]

[ "MAP7" ]

[ 8781 ]

1

[]

0

[ "7sgs" ]

1

[ "PUB00068052", "PUB00068053", "PUB00073824", "PUB00073826", "PUB00073827" ]

[ "11719555", "9989799", "24927501", "22142902", "24614595" ]

[ "Rapid dynamics of the microtubule binding of ensconsin in vivo.", "Upregulation and redistribution of E-MAP-115 (epithelial microtubule-associated protein of 115 kDa) in terminally differentiating keratinocytes is coincident with the formation of intercellular contacts.", "C-terminal region of MAP7 domain cont...

[ 2001, 1999, 2014, 2011, 2014 ]

5

[]

0

null

[ "Eumetazoa", "bird metagenome" ]

[ 8780, 1 ]

2

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 91, 12, 23, 10, 21 ]

5

true

Family

Microtubule-associated protein 7 family

MAP7_fam

1

IPR008605

8,605

Extracellular matrix protein 1

ECM1

Family

1,063

false

This family consists of several eukaryotic extracellular matrix protein 1 (ECM1) sequences. ECM1 has been shown to regulate endochondral bone formation, stimulate the proliferation of endothelial cells and induce angiogenesis [ , ]. Mutations in the ECM1 gene can cause lipoid proteinosis, a disorder which causes genera...

[ "GO:0007165", "GO:0005576" ]

[ "signal transduction", "extracellular region" ]

[ "biological_process", "cellular_component" ]

2

[ "PFAM", "PANTHER" ]

[ "PF05782", "PTHR16776" ]

[ "ECM1", "" ]

[ 1062, 1038 ]

2

[ "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-114608", "R-MMU-114608", "R-RNO-114608" ]

[ "REACTOME:R-HSA-114608", "REACTOME:R-MMU-114608", "REACTOME:R-RNO-114608" ]

3

[]

0

[ "PUB00011326", "PUB00019491", "PUB00019492" ]

[ "11929856", "11165938", "11292659" ]

[ "Lipoid proteinosis maps to 1q21 and is caused by mutations in the extracellular matrix protein 1 gene (ECM1).", "Recombinant human extracellular matrix protein 1 inhibits alkaline phosphatase activity and mineralization of mouse embryonic metatarsals in vitro.", "Extracellular matrix protein 1 (ECM1) has angio...

[ 2002, 2001, 2001 ]

3

[]

0

null

[ "Chordata" ]

[ 1063 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 4, 4, 15, 7 ]

4

true

Family

Extracellular matrix protein 1

ECM1

3

IPR008606

8,606

Eukaryotic translation initiation factor 4E binding

EIF4EBP

Family

3,261

false

This family consists of several eukaryotic translation initiation factor 4E binding proteins (EIF4EBP1, -2 and -3). Translation initiation in eukaryotes is mediated by the cap structure (m7GpppN, where N is any nucleotide) present at the 5' end of all cellular mRNAs, except organellar. The cap is recognised by eukaryot...

[ "GO:0008190", "GO:0045947" ]

[ "eukaryotic initiation factor 4E binding", "negative regulation of translational initiation" ]

[ "molecular_function", "biological_process" ]

2

[ "PFAM" ]

[ "PF05456" ]

[ "eIF_4EBP" ]

[ 3261 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-166208", "R-BTA-72662", "R-DDI-166208", "R-DDI-72662", "R-DME-110523", "R-DME-166208", "R-DME-72662", "R-HSA-166208", "R-HSA-72662", "R-MMU-166208", "R-MMU-72662", "R-RNO-166208", "R-RNO-72662" ]

[ "REACTOME:R-BTA-166208", "REACTOME:R-BTA-72662", "REACTOME:R-DDI-166208", "REACTOME:R-DDI-72662", "REACTOME:R-DME-110523", "REACTOME:R-DME-166208", "REACTOME:R-DME-72662", "REACTOME:R-HSA-166208", "REACTOME:R-HSA-72662", "REACTOME:R-MMU-166208", "REACTOME:R-MMU-72662", "REACTOME:R-RNO-166208",...

13

[ "1wkw", "2jgb", "2jgc", "2mx4", "3am7", "3hxg", "3hxi", "3m93", "3m94", "3u7x", "4ue8", "4ued", "5bxv", "5nvn", "6bcu", "6bcx", "8rch", "8rck", "8rcn", "9ed4" ]

20

[ "PUB00011327" ]

[ "9593750" ]

[ "4E-BP3, a new member of the eukaryotic initiation factor 4E-binding protein family." ]

[ 1998 ]

1

[]

0

null

[ "Eukaryota", "Legionella adelaidensis" ]

[ 3260, 1 ]

2

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 6, 1, 5, 6, 8 ]

5

true

Family

Eukaryotic translation initiation factor 4E binding

EIF4EBP

3

IPR008608

8,608

Ectropic viral integration site 2A protein

Ectropic_vir_integratn_site_2A

Family

652

false

This family contains several mammalian ectropic viral integration site 2A (EVI2A) proteins. The function of this protein is unknown although it is thought to be a membrane protein and may function as an oncogene in retrovirus induced myeloid tumours [ , ].

[ "GO:0016020" ]

[ "membrane" ]

[ "cellular_component" ]

1

[ "PFAM", "PIRSF", "PANTHER" ]

[ "PF05399", "PIRSF019625", "PTHR15568" ]

[ "EVI2A", "EVI_S2A", "" ]

[ 652, 353, 578 ]

3

[]

0

[]

0

[ "PUB00011593", "PUB00011594" ]

[ "2167436", "2117566" ]

[ "Evi-2, a common integration site involved in murine myeloid leukemogenesis.", "Identification and characterization of transcripts from the neurofibromatosis 1 region: the sequence and genomic structure of EVI2 and mapping of other transcripts." ]

[ 1990, 1990 ]

2

[]

0

null

[ "Eukaryota", "Pilibacter termitis" ]

[ 651, 1 ]

2

[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 5, 5, 2 ]

3

true

Family

Ectropic viral integration site 2A protein

Ectropic_vir_integratn_site_2A

9

IPR008609

8,609

Ebola nucleoprotein

Ebola_NP

Family

635

false

This family consists of Ebola virus sp., Lake Victoria marburgvirus nucleoproteins. These proteins are responsible for encapsidation of genomic RNA. It has been found that nucleoprotein DNA vaccines can offer protection from the virus [ ].

[ "GO:0019074", "GO:0019013" ]

[ "viral RNA genome packaging", "viral nucleocapsid" ]

[ "biological_process", "cellular_component" ]

2

[ "PFAM", "PIRSF" ]

[ "PF05505", "PIRSF003900" ]

[ "Ebola_NP", "N_FiloV" ]

[ 635, 457 ]

2

[]

0

[ "4qaz", "4qb0", "4w2o", "4w2q", "4ypi", "4z9p", "4zta", "4ztg", "4zti", "5dsd", "5e2x", "5f5m", "5f5o", "5vkd", "5w2b", "5xsq", "5z9w", "6app", "6c54", "6ehl", "6ehm", "6nut", "6oaf", "6u51", "6u52", "6u54", "6u55", "7f1m", "7ypw", "7yr8", "8p0y", "8p10"...

37

[ "PUB00011329" ]

[ "9657001" ]

[ "DNA vaccines expressing either the GP or NP genes of Ebola virus protect mice from lethal challenge." ]

[ 1998 ]

1

[]

0

null

[ "Filoviridae", "Myotis myotis" ]

[ 634, 1 ]

2

[]

0

true

Family

Ebola nucleoprotein

Ebola_NP

8

IPR008610

8,610

Eukaryotic rRNA processing

Ebp2

Family

4,721

false

This family consists of several eukaryotic rRNA processing protein EBP2 sequences. Ebp2p is required for the maturation of 25S rRNA and 60S subunit assembly. Ebp2p may be one of the target proteins of Rrs1p for executing the signal to regulate ribosome biogenesis [ ].

[]

0

[ "PFAM", "PANTHER" ]

[ "PF05890", "PTHR13028" ]

[ "Ebp2", "" ]

[ 4712, 4631 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-CEL-6791226", "R-DME-6791226", "R-HSA-6791226", "R-MMU-6791226", "R-SCE-6791226", "R-SPO-6791226" ]

[ "REACTOME:R-CEL-6791226", "REACTOME:R-DME-6791226", "REACTOME:R-HSA-6791226", "REACTOME:R-MMU-6791226", "REACTOME:R-SCE-6791226", "REACTOME:R-SPO-6791226" ]

6

[ "5z1g", "5z3g", "6elz", "6em1", "6em3", "6em4", "6em5", "7nac", "7ohr", "7ohv", "7ohw", "7r6k", "7r7a", "7r7c", "8e5t", "8esq", "8esr", "8eth", "8eti", "8eup", "8euy", "8ev3", "8fkp", "8fkq", "8fkr", "8fks", "8fkt", "8fku", "8fkv", "8fkw", "8fkx", "8fky"...

44

[ "PUB00011330" ]

[ "10947841" ]

[ "Ebp2p, yeast homologue of a human protein that interacts with Epstein-Barr virus nuclear antigen 1, is required for pre-rRNA processing and ribosomal subunit assembly." ]

[ 2000 ]

1

[]

0

null

[ "Eukaryota" ]

[ 4721 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 3, 1, 1, 1, 5, 2, 1, 2, 3, 1, 1, 4 ]

12

true

Family

Eukaryotic rRNA processing

Ebp2

3

IPR008611

8,611

SPI-2 type 3 secretion system translocon protein SctB-like

SctB2-like

Family

810

false

This entry represents a protein family that includes SPI-2 type 3 secretion system translocon protein SctB from Salmonella typhimurium (SctB2) and similar bacterial sequences. SctB2 is required for the translocation of SPI-2 effector proteins [ ] and for systemic Salmonella infection of the mouse [ ]. It is also essent...

[]

0

[ "NCBIFAM", "PFAM" ]

[ "NF011888", "PF05802" ]

[ "PRK15361.1", "SctB2" ]

[ 554, 810 ]

2

[]

0

[]

0

[ "PUB00062064", "PUB00085104", "PUB00151492", "PUB00154347" ]

[ "8393004", "18248436", "11567004", "11159962" ]

[ "A second chromosomal gene necessary for intimate attachment of enteropathogenic Escherichia coli to epithelial cells.", "Identification of Salmonella SPI-2 secretion system components required for SpvB-mediated cytotoxicity in macrophages and virulence in mice.", "SseBCD proteins are secreted by the type III s...

[ 1993, 2008, 2001, 2001 ]

4

[]

0

null

[ "Bacteria", "Bracon brevicornis", "freshwater metagenome" ]

[ 808, 1, 1 ]

3

[]

0

true

Family

SPI-2 type 3 secretion system translocon protein SctB-like

SctB2-like

6

IPR008613

8,613

Excalibur calcium-binding domain

Excalibur_Ca-bd_domain

Domain

8,203

false

Extracellular Ca 2+ -dependent nuclease YokF from Bacillus subtilis and several other surface-exposed proteins from diverse bacteria are encoded in the genomes in two paralogous forms that differ by a ~45 amino acid fragment, which comprises a novel conserved domain. Sequence analysis of this domain revealed a conserve...

[]

0

[ "PFAM", "SMART" ]

[ "PF05901", "SM00894" ]

[ "Excalibur", "Excalibur" ]

[ 8151, 6598 ]

2

[]

0

[ "5j8t" ]

1

[ "PUB00011334" ]

[ "12694917" ]

[ "An extracellular calcium-binding domain in bacteria with a distant relationship to EF-hands." ]

[ 2003 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 28, 8040, 25, 24, 86 ]

5

[]

0

true

Domain

Excalibur calcium-binding domain

Excalibur_Ca-bd_domain

7

IPR008614

8,614

Acidic fibroblast growth factor intracellular-binding protein

FIBP

Family

1,824

false

Acidic fibroblast growth factor (aFGF) intracellular binding protein (FIBP) is a protein found mainly in the nucleus that is thought to be involved in the intracellular function of aFGF [ ].

[]

0

[ "PFAM", "PANTHER" ]

[ "PF05427", "PTHR13223" ]

[ "FIBP", "" ]

[ 1780, 1786 ]

2

[]

0

[]

0

[ "PUB00011335" ]

[ "11104667" ]

[ "Organization, chromosomal localization and promoter analysis of the gene encoding human acidic fibroblast growth factor intracellular binding protein." ]

[ 2000 ]

1

[]

0

null

[ "Eukaryota", "bird metagenome" ]

[ 1822, 2 ]

2

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 7, 5, 8, 4, 6 ]

5

true

Family

Acidic fibroblast growth factor intracellular-binding protein

FIBP

9

IPR008615

8,615

FNIP

Repeat

3,366

false

This short repeat is predominantly found in proteins from mimivirus and lower eukaryotes, including Calmodulin-binding protein CmbB from Dictyostelium discoideum (Social amoeba). It appears to be related to . The alignment consists of two tandem repeats. It is termed the FNIP repeat after the pattern of conserved resid...

[]

0

[ "PFAM" ]

[ "PF05725" ]

[ "FNIP" ]

[ 3366 ]

1

[]

0

[ "6nyr", "6nys", "7zal" ]

3

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Viruses", "metagenomes" ]

[ 5, 2310, 894, 157 ]

4

[]

0

true

Repeat

FNIP

3

IPR008617

8,617

Uncharacterised protein family, YcgJ

Uncharacterised_YcgJ

Family

443

false

The function of these proteins is unknown.

[]

0

[ "PFAM" ]

[ "PF05666" ]

[ "YcgJ" ]

[ 443 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Oppiella nova" ]

[ 442, 1 ]

2

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Uncharacterised protein family, YcgJ

Uncharacterised_YcgJ

3

IPR008618

8,618

Protein S10

S10

Family

342

false

This family consists of several Fijivirus Protein S10.

[]

0

[ "PFAM" ]

[ "PF05880" ]

[ "Fiji_64_capsid" ]

[ 342 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Reovirales" ]

[ 342 ]

1

[]

0

true

Family

Protein S10

S10

9

IPR008620

8,620

Nitrogen fixation protein FixH

FixH

Family

7,623

false

This family consists of several Rhizobium FixH like proteins. It has been suggested that the four proteins FixG, FixH, FixI, and FixS may participate in a membrane-bound complex coupling the FixI cation pump with a redox process catalysed by FixG [ ].

[]

0

[ "PFAM" ]

[ "PF05751" ]

[ "FixH" ]

[ 7623 ]

1

[]

0

[ "6xkw" ]

1

[ "PUB00011338" ]

[ "2536685" ]

[ "Rhizobium meliloti fixGHI sequence predicts involvement of a specific cation pump in symbiotic nitrogen fixation." ]

[ 1989 ]

1

[]

[ "IPR018037" ]

0

1

0

[ "Bacteria", "Eukaryota", "Halobacteriales", "unclassified sequences" ]

[ 7523, 5, 6, 89 ]

4

[]

0

true

Family

Nitrogen fixation protein FixH

FixH

5

IPR008621

8,621

Cbb3-type cytochrome oxidase component

Cbb3-typ_cyt_oxidase_comp

Family

5,799

false

This family consists of several Cbb3-type cytochrome oxidase components (FixQ/CcoQ). FixQ is found in nitrogen fixing bacteria. Since nitrogen fixation is an energy-consuming process, effective symbioses depend on operation of a respiratory chain with a high affinity for O2, closely coupled to ATP production. This requ...

[]

0

[ "PFAM", "CDD" ]

[ "PF05545", "cd01324" ]

[ "FixQ", "cbb3_Oxidase_CcoQ" ]

[ 5709, 4365 ]

2

[ "GP" ]

[ "GenProp0483" ]

[ "GP:GenProp0483" ]

1

[]

0

[ "PUB00011339", "PUB00016261", "PUB00081794", "PUB00081795", "PUB00081796", "PUB00081797" ]

[ "11717256", "11864982", "12196157", "12070166", "11707262", "14714103" ]

[ "Regulation of gene expression in response to oxygen in Rhizobium etli: role of FnrN in fixNOQP expression and in symbiotic nitrogen fixation.", "Oxygen adaptation. The role of the CcoQ subunit of the cbb3 cytochrome c oxidase of Rhodobacter sphaeroides 2.4.1.", "Cytochrome cbb(3) oxidase and bacterial microaer...

[ 2001, 2002, 2002, 2002, 2001, 2004 ]

6

[]

[ "IPR014107" ]

0

1

0

[ "Bacteria", "Hyalomma marginatum", "unclassified sequences" ]

[ 5725, 1, 73 ]

3

[]

0

true

Family

Cbb3-type cytochrome oxidase component

Cbb3-typ_cyt_oxidase_comp

1

IPR008622

8,622

Flagellar protein FliT

FliT

Family

5,637

false

This entry represents the bacterial flagellar FliT family of dual-function proteins. Together with FlgN, FliT has been proposed to act as a substrate-specific export chaperone, facilitating the incorporation of the enterobacterial hook-associated axial proteins (HAPs) FlgK/FlgL and FliD into the growing flagellum [ ]. ...

[]

0

[ "HAMAP", "PFAM" ]

[ "MF_01180", "PF05400" ]

[ "FliT", "FliT" ]

[ 620, 5637 ]

2

[ "GP" ]

[ "GenProp0881" ]

[ "GP:GenProp0881" ]

1

[ "3a7m", "3h3m", "3nkz", "5gna", "5kp0", "5krw", "5ks6", "6ch2", "8ftw" ]

9

[ "PUB00010163", "PUB00054965" ]

[ "11169117", "10791024" ]

[ "Substrate complexes and domain organization of the Salmonella flagellar export chaperones FlgN and FliT.", "Two novel regulatory genes, fliT and fliZ, in the flagellar regulon of Salmonella." ]

[ 2001, 1999 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 5574, 11, 52 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Flagellar protein FliT

FliT

3

IPR008629

8,629

GUN4-like

Domain

3,343

false

GUN4 is a porphyrin-binding protein involved in chlorophyll biosynthesis regulation and intracellular signaling, found in aerobic photosynthetic organisms [ , ]. It has been implicated in retrograde signalling between the chloroplast and nucleus [ ]. GUN4 can bind protoporphyrin IX (PIX) and magnesium protoporphyrin IX...

[]

0

[ "PFAM", "PANTHER", "CDD" ]

[ "PF05419", "PTHR34800", "cd16383" ]

[ "GUN4", "", "GUN4" ]

[ 3342, 2719, 3010 ]

3

[]

0

[ "1y6i", "1z3x", "1z3y", "4xkb", "4xkc", "4ykb", "7e2r", "7e2s", "7e2t", "7e2u" ]

10

[ "PUB00019664", "PUB00038437", "PUB00085717", "PUB00085718", "PUB00085719" ]

[ "12574634", "15884974", "26969164", "26249706", "21467578" ]

[ "GUN4, a regulator of chlorophyll synthesis and intracellular signaling.", "Structure of the Mg-chelatase cofactor GUN4 reveals a novel hand-shaped fold for porphyrin binding.", "GUN4-Protoporphyrin IX Is a Singlet Oxygen Generator with Consequences for Plastid Retrograde Signaling.", "Structure of GUN4 from ...

[ 2003, 2005, 2016, 2015, 2011 ]

5

[]

0

null

[ "Bacteria", "Eukaryota" ]

[ 2413, 930 ]

2

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 3, 2, 3 ]

3

true

Domain

GUN4-like

7

IPR008630

8,630

Glycosyltransferase 34

Glyco_trans_34

Family

10,836

false

This family represents a group of glycosyltransferases from plants and fungi, including Mnn10/Mnn11 from budding yeasts, Gma12/Gmh1-3 from fission yeasts and xyloglucan 6-xylosyltransferase 1/2 (XXT1/XXT2) from Arabidopsis. Mnn10 and Mnn11 are subunits of a Golgi mannosyltransferase complex, which mediates elongation o...

[ "GO:0016757", "GO:0016020" ]

[ "glycosyltransferase activity", "membrane" ]

[ "molecular_function", "cellular_component" ]

2

[ "PFAM", "PANTHER", "PANTHER" ]

[ "PF05637", "PTHR31306", "PTHR31311" ]

[ "Glyco_transf_34", "", "" ]

[ 9499, 6637, 3975 ]

3

[]

0

[ "2p6w", "2p72", "2p73", "6bsu", "6bsv", "6bsw" ]

6

[ "PUB00019634", "PUB00074881", "PUB00074882" ]

[ "9839953", "10037752", "18544630" ]

[ "Differences in in vivo acceptor specificity of two galactosyltransferases, the gmh3+ and gma12+ gene products from Schizosaccharomyces pombe.", "The Saccharomyces cerevisiae protein Mnn10p/Bed1p is a subunit of a Golgi mannosyltransferase complex.", "Disrupting two Arabidopsis thaliana xylosyltransferase genes...

[ 1998, 1999, 2008 ]

3

[]

0

null

[ "Bacteria", "Eukaryota", "Viruses", "metagenomes" ]

[ 318, 10457, 21, 40 ]

4

[ "Arabidopsis thaliana", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)", "Zea mays" ]

[ 30, 4, 14, 2, 7, 67 ]

6

true

Family

Glycosyltransferase 34

Glyco_trans_34

4

IPR008631

8,631

Glycogen synthase

Glycogen_synth

Family

6,855

false

This family consists of the eukaryotic glycogen synthase proteins GYS1 and GYS2. Glycogen synthase (GS) is the enzyme responsible for the synthesis of -1,4-linked glucose chains in glycogen. It is the rate limiting enzyme in the synthesis of the polysaccharide, and its activity is highly regulated through phosphorylati...

[ "GO:0004373", "GO:0005978" ]

[ "alpha-1,4-glucan glucosyltransferase (UDP-glucose donor) activity", "glycogen biosynthetic process" ]

[ "molecular_function", "biological_process" ]

2

[ "PFAM", "PANTHER" ]

[ "PF05693", "PTHR10176" ]

[ "Glycogen_syn", "" ]

[ 6846, 6644 ]

2

[ "EC", "GP", "GP", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "2.4.1.11", "GenProp1483", "GenProp2088", "PWY-5067", "R-BTA-3322077", "R-CEL-3322077", "R-DDI-3322077", "R-DME-3322077", "R-HSA-3322077", "R-HSA-3785653", "R-HSA-3814836", "R-HSA-3828062", "R-HSA-3858516", "R-HSA-3878781", "R-MMU-3322077", "R-RNO-3322077", "R-SCE-3322077" ]

[ "EC:2.4.1.11", "GP:GenProp1483", "GP:GenProp2088", "METACYC:PWY-5067", "REACTOME:R-BTA-3322077", "REACTOME:R-CEL-3322077", "REACTOME:R-DDI-3322077", "REACTOME:R-DME-3322077", "REACTOME:R-HSA-3322077", "REACTOME:R-HSA-3785653", "REACTOME:R-HSA-3814836", "REACTOME:R-HSA-3828062", "REACTOME:R-H...

17

[ "3naz", "3nb0", "3nch", "3o3c", "3rsz", "3rt1", "4kq1", "4kq2", "4kqm", "4qlb", "5suk", "5sul", "5uw0", "5uw1", "5uw4", "5ux7", "5vnc", "6u77", "7q0b", "7q0s", "7q12", "7q13", "7zbn", "8cvx", "8cvy", "8cvz", "8z0a" ]

27

[ "PUB00011344" ]

[ "11415431" ]

[ "Intracellular distribution of glycogen synthase and glycogen in primary cultured rat hepatocytes." ]

[ 2001 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "metagenomes" ]

[ 77, 1003, 5721, 54 ]

4

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)" ]

[ 1, 3, 3, 9, 4, 1, 7, 2 ]

8

true

Family

Glycogen synthase

Glycogen_synth

6

IPR008632

8,632

Nematode fatty acid retinoid binding

Gp-FAR-1

Family

1,014

false

Parasitic nematodes produce at least two structurally novel classes of small helix-rich retinol- and fatty-acid-binding proteins that have no counterparts in their plant or animal hosts and thus represent potential targets for new nematicides. Gp-FAR-1 is a member of the nematode-specific fatty-acid- and retinol-bindin...

[ "GO:0008289" ]

[ "lipid binding" ]

[ "molecular_function" ]

1

[ "PFAM", "PANTHER" ]

[ "PF05823", "PTHR31418" ]

[ "Gp-FAR-1", "" ]

[ 934, 600 ]

2

[]

0

[ "2w9y", "4uet", "4xcp" ]

3

[ "PUB00011345" ]

[ "11368765" ]

[ "A surface-associated retinol- and fatty acid-binding protein (Gp-FAR-1) from the potato cyst nematode Globodera pallida: lipid binding activities, structural analysis and expression pattern." ]

[ 2001 ]

1

[]

0

null

[ "Bacteria", "Protostomia" ]

[ 9, 1005 ]

2

[ "Caenorhabditis elegans" ]

[ 12 ]

1

true

Family

Nematode fatty acid retinoid binding

Gp-FAR-1

3

IPR008633

8,633

Gas vesicle protein H

GvpH

Family

108

false

This family consists of prokaryotic GvpH proteins which may be involved in gas vesicle synthesis, including Gas vesicle protein H from Haloferax mediterranei [ ].

[]

0

[ "PFAM" ]

[ "PF05455" ]

[ "GvpH" ]

[ 108 ]

1

[]

0

[]

0

[ "PUB00011346" ]

[ "9211710" ]

[ "The characterization of the nv-gvpACNOFGH gene cluster involved in gas vesicle formation in Natronobacterium vacuolatum." ]

[ 1997 ]

1

[]

0

null

[ "Bacteria", "Halobacteriales", "mine drainage metagenome" ]

[ 26, 81, 1 ]

3

[]

0

true

Family

Gas vesicle protein H

GvpH

3

IPR008634

8,634

Gas vesicle protein GvpO

Gas-vesicle_GvpO

Domain

2,157

false

This entry represents prokaryotic GvpO proteins which are required for gas vesicle synthesis [ ], including Gas vesicle protein O from Streptomyces sp.

[ "GO:0031412" ]

[ "gas vesicle organization" ]

[ "biological_process" ]

1

[ "PFAM", "PIRSF" ]

[ "PF05800", "PIRSF028743" ]

[ "GvpO", "GvpO_protein" ]

[ 2157, 1174 ]

2

[ "GP" ]

[ "GenProp0460" ]

[ "GP:GenProp0460" ]

1

[]

0

[ "PUB00011347" ]

[ "8606186" ]

[ "Functional studies of the gvpACNO operon of Halobacterium salinarium reveal that the GvpC protein shapes gas vesicles." ]

[ 1996 ]

1

[]

0

null

[ "Bacteria", "Batrachochytrium dendrobatidis (strain JAM81 / FGSC 10211)", "Stenosarchaea group", "marine sediment metagenome" ]

[ 1996, 1, 158, 2 ]

4

[]

0

true

Domain

Gas vesicle protein GvpO

Gas-vesicle_GvpO

9

IPR008635

8,635

Trimeric autotransporter adhesin YadA-like, stalk domain

Coiled_stalk_dom

Domain

10,096

false

This is the stalk domain of the trimeric autotransporter adhesin YadA. The coiled-coil neck region makes the transition from the globular head region to the narrower stalk domain [ ]. The stalk domain confers serum resistance [ ]. The Yersinia adhesin A (YadA) is a trimeric autotransporter adhesin of enteric yersiniae....

[ "GO:0019867" ]

[ "outer membrane" ]

[ "cellular_component" ]

1

[ "PFAM" ]

[ "PF05662" ]

[ "YadA_stalk" ]

[ 10096 ]

1

[]

0

[ "1p9h", "2ynz", "2yo0", "2yo1", "2yo2", "2yo3", "3d9x", "3emo", "3la9", "3laa", "3ntn", "3pr7", "3s6l", "3wp8", "3wpa", "3wpo", "3wpp", "3wpr", "3wqa", "3zmf", "4lgo", "4usx", "6qp4", "7o23", "8es4", "8x8m", "8x8o", "9gh4", "9gh5", "9u93", "9u94" ]

31

[ "PUB00029784", "PUB00095166", "PUB00095167" ]

[ "14765110", "17921300", "12813066" ]

[ "The Yersinia adhesin YadA collagen-binding domain structure is a novel left-handed parallel beta-roll.", "A conserved glycine residue of trimeric autotransporter domains plays a key role in Yersinia adhesin A autotransport.", "Molecular analysis of transport and oligomerization of the Yersinia enterocolitica a...

[ 2004, 2007, 2003 ]

3

[]

0

null

[ "Bacteria", "Eukaryota", "Viruses", "metagenomes" ]

[ 9932, 32, 84, 48 ]

4

[]

0

true

Domain

Trimeric autotransporter adhesin YadA-like, stalk domain

Coiled_stalk_dom

4

IPR008636

8,636

Hook, C-terminal

Hook_C

Domain

5,988

false

The Hook family consists of several proteins from different eukaryotic organisms, first identified in Drosophila melanogaster in which play a role in endocytic cargo sorting [ ]. In Drosophila and fungi there is a single Hook gene, whereas mammals have three Hook genes, Hook1, Hook2 and Hook3. Endogenous Hook3 binds to...

[ "GO:0008017", "GO:0031122" ]

[ "microtubule binding", "cytoplasmic microtubule organization" ]

[ "molecular_function", "biological_process" ]

2

[ "PFAM" ]

[ "PF05622" ]

[ "HOOK" ]

[ 5988 ]

1

[]

0

[ "8qat", "9kns", "9ko8" ]

3

[ "PUB00011348", "PUB00011349", "PUB00094629", "PUB00094633" ]

[ "11238449", "12075009", "27482052", "11018772" ]

[ "The Golgi-associated hook3 protein is a member of a novel family of microtubule-binding proteins.", "The Hook1 gene is non-functional in the abnormal spermatozoon head shape (azh) mutant mouse.", "Assembly and activation of dynein-dynactin by the cargo adaptor protein Hook3.", "Drosophila endosomal proteins ...

[ 2001, 2002, 2016, 2000 ]

4

[]

0

null

[ "Eukaryota" ]

[ 5988 ]

1

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 9, 1, 12, 10, 18 ]

5

true

Domain

Hook, C-terminal

Hook_C

2

IPR008637

8,637

HR-like lesion-inducer

HR_lesion

Family

2,039

false

This is a family of plant proteins that are associated with the hypersensitive response (HR) pathway of defence against plant pathogens. This family belongs to the DoxD-like superfamily. Members of this family like other members of this superfamily are likely to form homodimers.

[]

0

[ "PFAM" ]

[ "PF05514" ]

[ "HR_lesion" ]

[ 2039 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Halobacteriales" ]

[ 10, 2010, 19 ]

3

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 25, 10, 32 ]

3

true

Family

HR-like lesion-inducer

HR_lesion

2

IPR008638

8,638

Filamentous haemagglutinin FhaB/tRNA nuclease CdiA-like, TPS domain

FhaB/CdiA-like_TPS

Domain

13,799

false

This entry represents a conserved TPS (two-partner secretion) transport domain found near the N terminus of a number of large, repetitive bacterial proteins, including tRNA nuclease CdiA from Escherichia coli, Filamentous hemagglutinin from Bordetella pertussis (FhaB) and Hemolysin from Proteus mirabilis (HpmA). CdiA i...

[]

0

[ "PFAM", "SMART", "NCBIFAM" ]

[ "PF05860", "SM00912", "TIGR01901" ]

[ "TPS", "Haemagg_act", "adhes_NPXG" ]

[ 13097, 13278, 13298 ]

3

[]

0

[ "1rwr", "2odl", "3fy3", "4i84", "4rm6", "4rt6", "4w8q", "4w8r", "4w8s", "4w8t", "5kdk", "5keh", "5kf3", "5kkd", "5sz8", "6pyk", "6pzl", "6q0p", "8cpk", "8vba", "8vbb" ]

21

[ "PUB00011350", "PUB00030822", "PUB00052927", "PUB00100046", "PUB00101139", "PUB00101226", "PUB00101227" ]

[ "11703654", "15079085", "19494116", "30388452", "29923643", "28291749", "28351921" ]

[ "Beta-helix model for the filamentous haemagglutinin adhesin of Bordetella pertussis and related bacterial secretory proteins.", "The crystal structure of filamentous hemagglutinin secretion domain and its implications for the two-partner secretion pathway.", "Structural and functional studies of truncated hemo...

[ 2001, 2004, 2009, 2018, 2018, 2017, 2017 ]

7

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 13685, 22, 92 ]

3

[]

0

true

Domain

Filamentous haemagglutinin FhaB/tRNA nuclease CdiA-like, TPS domain

FhaB/CdiA-like_TPS

9

IPR008639

8,639

Gas vesicle protein GvpC, halobacteria

Gas-vesicle_GvpC_halobac

Family

28

false

This family consists of Halobacterium gas vesicle protein C sequences which are thought to confer stability to the gas vesicle membranes [ , ].

[ "GO:0031412", "GO:0031411" ]

[ "gas vesicle organization", "gas vesicle" ]

[ "biological_process", "cellular_component" ]

2

[ "PFAM" ]

[ "PF05465" ]

[ "Halo_GVPC" ]

[ 28 ]

1

[ "GP" ]

[ "GenProp0460" ]

[ "GP:GenProp0460" ]

1

[]

0

[ "PUB00010169", "PUB00011595" ]

[ "1404376", "8763925" ]

[ "Three different but related gene clusters encoding gas vesicles in halophilic archaea.", "Transcript analysis of the c-vac region and differential synthesis of the two regulatory gas vesicle proteins GvpD and GvpE in Halobacterium salinarium PHH4." ]

[ 1992, 1996 ]

2

[]

0

null

[ "Halobacteriales", "Punica granatum" ]

[ 27, 1 ]

2

[]

0

true

Family

Gas vesicle protein GvpC, halobacteria

Gas-vesicle_GvpC_halobac

1

IPR008640

8,640

Trimeric autotransporter adhesin YadA-like, head domain

Adhesin_Head_dom

Domain

9,694

false

This entry represents the head domain of YadA. This domain is composed almost solely of β-sheets making a novel nine coiled left-handed parallel β-roll (LPBR), surrounded by a partly disordered (N)-terminal random coil and a C-terminal neck region, which consists of a random coil and a short helix at the start of the s...

[ "GO:0019867" ]

[ "outer membrane" ]

[ "cellular_component" ]

1

[ "PFAM" ]

[ "PF05658" ]

[ "YadA_head" ]

[ 9694 ]

1

[]

0

[ "1p9h", "2xqh", "2yo0", "2yo1", "2yo3", "3la9", "3laa", "3ntn", "3pr7", "3s6l", "3wp8", "4usx", "7o23", "9gh4", "9gh5", "9u93", "9u94" ]

17

[ "PUB00029784", "PUB00095166" ]

[ "14765110", "17921300" ]

[ "The Yersinia adhesin YadA collagen-binding domain structure is a novel left-handed parallel beta-roll.", "A conserved glycine residue of trimeric autotransporter domains plays a key role in Yersinia adhesin A autotransport." ]

[ 2004, 2007 ]

2

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "metagenomes" ]

[ 9, 9496, 63, 52, 74 ]

5

[]

0

true

Domain

Trimeric autotransporter adhesin YadA-like, head domain

Adhesin_Head_dom

2

IPR008642

8,642

Herpesvirus BLRF2

Herpes_BLRF2

Family

94

false

This family consists of several herpes virus BLRF2 tegument proteins.

[]

0

[ "PFAM" ]

[ "PF05812" ]

[ "Herpes_BLRF2" ]

[ 94 ]

1

[]

0

[ "2h3r", "2oa5", "7tdq" ]

3

[]

0

[]

0

null

[ "Orthoherpesviridae", "Pseudomonadati" ]

[ 89, 5 ]

2

[]

0

true

Family

Herpesvirus BLRF2

Herpes_BLRF2

3

IPR008644

8,644

Human herpesvirus U15

Herpes_U15

Family

22

false

U15 is an ORF present in human herpesvirus 6 (HHV-6) that was initially isolated from patients with the AIDS and lymphoproliferative disorders, but was subsequently shown to be responsible for the common childhood disease exanthema subitum (roseola). Several gene fragments of HHV-6 have been shown to activate the human...

[]

0

[ "PFAM" ]

[ "PF05613" ]

[ "Herpes_U15" ]

[ 22 ]

1

[]

0

[]

0

[ "PUB00011544" ]

[ "11069999" ]

[ "Characterization of transcripts expressed from human herpesvirus 6A strain GS immediate-early region B U16-U17 open reading frames." ]

[ 2000 ]

1

[]

0

null

[ "Homo sapiens", "Roseolovirus" ]

[ 1, 21 ]

2

[ "Homo sapiens" ]

[ 1 ]

1

true

Family

Human herpesvirus U15

Herpes_U15

5

IPR008645

8,645

Roseolovirus glycoprotein U47

Roseolovirus_U47

Family

102

false

This is a family of U47 herpesvirus proteins [ ]. U47 protein is also known as 120kDa glycoprotein O (or 130kDa glycoprotein O from human herpesvirus 6A). U47 proteins are modified with N-linked oligosaccharides and co-immunoprecipitated with glycoprotein H. They may have a role in cell-cell fusion in virus infection [...

[]

0

[ "PFAM" ]

[ "PF05467" ]

[ "Herpes_U47" ]

[ 102 ]

1

[]

0

[]

0

[ "PUB00011545", "PUB00086038" ]

[ "10482554", "16476971" ]

[ "Comparison of the complete DNA sequences of human herpesvirus 6 variants A and B.", "Human herpesvirus 7 U47 gene products are glycoproteins expressed in virions and associate with glycoprotein H." ]

[ 1999, 2006 ]

2

[]

0

null

[ "Homo sapiens", "Roseolovirus" ]

[ 1, 101 ]

2

[ "Homo sapiens" ]

[ 1 ]

1

true

Family

Roseolovirus glycoprotein U47

Roseolovirus_U47

6

IPR008647

8,647

Envelope glycoprotein N domain

GN_domain

Domain

243

false

Glycoprotein N (gN) is a Herpesvirus envelope glycoprotein necessary for proper maturation of glycoprotein M (gM) [ ]. This entry represents the C-terminal domain.

[]

0

[ "PFAM" ]

[ "PF05702" ]

[ "Herpes_UL49_5" ]

[ 243 ]

1

[]

0

[ "6qan", "6qbj", "9o9d" ]

3

[ "PUB00078897" ]

[ "20106918" ]

[ "Characterization of the varicella-zoster virus ORF50 gene, which encodes glycoprotein M." ]

[ 2010 ]

1

[]

0

null

[ "Eukaryota", "Haloplanus litoreus", "Orthoherpesviridae" ]

[ 109, 1, 133 ]

3

[]

0

true

Domain

Envelope glycoprotein N domain

GN_domain

3

IPR008648

8,648

Herpesvirus ICP27-like

ICP27-like

Family

534

false

This entry includes a group of proteins from Herpesviridae, including ICP27 from Human herpesvirus 1. ICP27 is a multifunctional regulatory protein that plays an essential role in viral transcription, nuclear export of intronless RNAs, translation of viral transcripts, and virion host shutoff function [ ]. It interacts...

[ "GO:0006355" ]

[ "regulation of DNA-templated transcription" ]

[ "biological_process" ]

1

[ "PFAM" ]

[ "PF05459" ]

[ "Herpes_UL69" ]

[ 534 ]

1

[ "REACTOME", "REACTOME" ]

[ "R-HSA-9609690", "R-HSA-9610379" ]

[ "REACTOME:R-HSA-9609690", "REACTOME:R-HSA-9610379" ]

2

[ "4yxp", "5bqk", "5zb1", "5zb3", "6hat", "6hau" ]

6

[ "PUB00084350", "PUB00084351", "PUB00084352" ]

[ "22334672", "26085142", "27791013" ]

[ "Herpes simplex virus ICP27 protein directly interacts with the nuclear pore complex through Nup62, inhibiting host nucleocytoplasmic transport pathways.", "Structure of the C-Terminal Domain of the Multifunctional ICP27 Protein from Herpes Simplex Virus 1.", "Herpes simplex virus ICP27 regulates alternative pr...

[ 2012, 2015, 2016 ]

3

[]

0

null

[ "Homo sapiens", "Orthoherpesviridae" ]

[ 1, 533 ]

2

[ "Homo sapiens" ]

[ 1 ]

1

true

Family

Herpesvirus ICP27-like

ICP27-like

1

IPR008649

8,649

Herpesvirus UL82/UL83

Herpes_UL82/UL83

Family

228

false

This family represents the N-terminal region of the UL82 and UL83 proteins from Betaherpesvirus sp., such as Human cytomegalovirus (HHV-5) (Human herpesvirus 5). As viruses are reliant upon their host cell to serve as proper environments for their replication, many have evolved mechanisms to alter intracellular conditi...

[]

0

[ "PFAM" ]

[ "PF05784" ]

[ "Herpes_UL82_83" ]

[ 228 ]

1

[ "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-198933", "R-HSA-9609690", "R-HSA-9610379" ]

[ "REACTOME:R-HSA-198933", "REACTOME:R-HSA-9609690", "REACTOME:R-HSA-9610379" ]

3

[ "8qdo" ]

1

[ "PUB00011354" ]

[ "12610120" ]

[ "The human cytomegalovirus UL82 gene product (pp71) accelerates progression through the G1 phase of the cell cycle." ]

[ 2003 ]

1

[]

0

null

[ "Betaherpesvirinae", "Homo sapiens" ]

[ 227, 1 ]

2

[ "Homo sapiens" ]

[ 1 ]

1

true

Family

Herpesvirus UL82/UL83

Herpes_UL82/UL83

7

IPR008650

8,650

Herpesvirus, helicase-primase complex component

Helicase-primas_cplx_Herpesvir

Domain

55

false

This family consists of several helicase-primase complex components from the Gammaherpesviruses.

[]

0

[ "PFAM" ]

[ "PF05774" ]

[ "Herpes_heli_pri" ]

[ 55 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Orthoherpesviridae" ]

[ 55 ]

1

[]

0

true

Domain

Herpesvirus, helicase-primase complex component

Helicase-primas_cplx_Herpesvir

7

IPR008651

8,651

Uncharacterised protein family HicB

Uncharacterised_HicB

Family

6,668

false

This family consists of several bacterial HicB related proteins. The function of HicB is unknown although it is thought to be involved in pilus formation. It has been speculated that HicB performs a function antagonistic to that of pili and yet is necessary for invasion of certain niches [ ].

[]

0

[ "PFAM" ]

[ "PF05534" ]

[ "HicB" ]

[ 6668 ]

1

[]

0

[]

0

[ "PUB00011355" ]

[ "9721313" ]

[ "Evolution of the major pilus gene cluster of Haemophilus influenzae." ]

[ 1998 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "metagenomes" ]

[ 3, 6512, 5, 29, 119 ]

5

[]

0

true

Family

Uncharacterised protein family HicB

Uncharacterised_HicB

6

IPR008652

8,652

Adenovirus type 2, E3A glycoprotein

Adenovirus_Type-2_E3A

Family

115

false

This family consists of several early glycoproteins (E3A) and adenovirus death protein, from human adenovirus type 2.

[ "GO:0016020" ]

[ "membrane" ]

[ "cellular_component" ]

1

[ "PFAM" ]

[ "PF05393" ]

[ "Hum_adeno_E3A" ]

[ 115 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Euteleostomi", "Mastadenovirus", "Pseudomonadati" ]

[ 4, 109, 2 ]

3

[ "Rattus norvegicus" ]

[ 1 ]

1

true

Family

Adenovirus type 2, E3A glycoprotein

Adenovirus_Type-2_E3A

8

IPR008653

8,653

Immediate early response

IER

Family

1,894

false

This family consists of eukaryotic immediate early response (IER) proteins 2 and 5. The role of IER5 is unclear, although it plays an important role in mediating the cellular response to mitogenic signals. Again, little is known about the function of IER2, although it is thought to play a role in mediating cellular res...

[]

0

[ "PFAM", "PANTHER" ]

[ "PF05760", "PTHR15895" ]

[ "IER", "" ]

[ 1882, 1821 ]

2

[]

0

[ "8uo5" ]

1

[ "PUB00011567", "PUB00011568" ]

[ "11102586", "10049588" ]

[ "Gene expression in the brain across the sleep-waking cycle.", "Ier5, a novel member of the slow-kinetics immediate-early genes." ]

[ 2000, 1999 ]

2

[]

0

null

[ "Opisthokonta" ]

[ 1894 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 6, 5, 6, 7 ]

4

true

Family

Immediate early response

IER

3

IPR008655

8,655

Helicobacter pylori IceA2

IceA2

Family

51

false

This family consists of several Helicobacter pylori specific IceA2 proteins. The function of this family is unknown.

[]

0

[ "PFAM" ]

[ "PF05862" ]

[ "IceA2" ]

[ 51 ]

1

[]

0

[ "7xfp" ]

1

[]

0

[]

0

null

[ "Bacteria" ]

[ 51 ]

1

[]

0

true

Family

Helicobacter pylori IceA2

IceA2

6

IPR008657

8,657

Jumping translocation breakpoint

JTB

Family

1,528

false

This family contains several jumping translocation breakpoint proteins or JTBs. Jumping translocation (JT) is an unbalanced translocation that comprises amplified chromosomal segments jumping to various telomeres. JTB, located at 1q21, has been found to fuse with the telomeric repeats of acceptor telomeres in a case of...

[ "GO:0016020" ]

[ "membrane" ]

[ "cellular_component" ]

1

[ "PFAM", "PANTHER" ]

[ "PF05439", "PTHR13041" ]

[ "JTB", "" ]

[ 1527, 1212 ]

2

[]

0

[ "2kjx" ]

1

[ "PUB00011357", "PUB00011358" ]

[ "10321732", "10762645" ]

[ "JTB: a novel membrane protein gene at 1q21 rearranged in a jumping translocation.", "PAR, a novel androgen regulated gene, ubiquitously expressed in normal and malignant cells." ]

[ 1999, 2000 ]

2

[]

0

null

[ "Eukaryota" ]

[ 1528 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 2, 2, 2, 5, 4 ]

6

true

Family

Jumping translocation breakpoint

JTB

9

IPR008658

8,658

Kinesin-associated protein 3

KAP3

Family

3,303

false

This family consists of kinesin-associated protein 3 (KAP3, also known as SMAP). In human and mouse, KAP3 is involved in tethering the chromosomes to the spindle pole and in chromosome movement. It binds to the tail domain of the KIF3A/KIF3B heterodimer to form a heterotrimeric KIF3 complex and may regulate the membran...

[ "GO:0019894", "GO:0005871" ]

[ "kinesin binding", "kinesin complex" ]

[ "molecular_function", "cellular_component" ]

2

[ "PANTHER" ]

[ "PTHR15605" ]

[ "" ]

[ 3303 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-1445148", "R-HSA-2132295", "R-HSA-5620924", "R-HSA-6811434", "R-HSA-983189", "R-MMU-2132295", "R-MMU-5620924", "R-MMU-6811434", "R-MMU-983189" ]

[ "REACTOME:R-HSA-1445148", "REACTOME:R-HSA-2132295", "REACTOME:R-HSA-5620924", "REACTOME:R-HSA-6811434", "REACTOME:R-HSA-983189", "REACTOME:R-MMU-2132295", "REACTOME:R-MMU-5620924", "REACTOME:R-MMU-6811434", "REACTOME:R-MMU-983189" ]

9

[ "9ikb", "9w9h", "9w9i" ]

3

[ "PUB00062065", "PUB00062066" ]

[ "8710890", "9506951" ]

[ "Cloning and characterization of KAP3: a novel kinesin superfamily-associated protein of KIF3A/3B.", "Complex formation of SMAP/KAP3, a KIF3A/B ATPase motor-associated protein, with a human chromosome-associated polypeptide." ]

[ 1996, 1998 ]

2

[]

0

null

[ "Eukaryota" ]

[ 3303 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 4, 2, 7, 3, 3, 8 ]

6

true

Family

Kinesin-associated protein 3

KAP3

9

IPR008660

8,660

Fibroin light chain

L-fibroin

Family

84

false

This family consists of several moth fibroin light chain (L-fibroin) proteins. Fibroin of Bombyx mori is secreted into the lumen of posterior silk gland (PSG) from the surrounding PSG cells as a molecular complex consisting of a heavy (H)-chain of approximately 350kDa, a light (L)-chain of 25kDa and a P25 of about 27kD...

[ "GO:0005576" ]

[ "extracellular region" ]

[ "cellular_component" ]

1

[ "PFAM", "PIRSF" ]

[ "PF05849", "PIRSF005765" ]

[ "L-fibroin", "L-fibroin" ]

[ 84, 41 ]

2

[]

0

[]

0

[ "PUB00011361" ]

[ "10366732" ]

[ "Determination of the site of disulfide linkage between heavy and light chains of silk fibroin produced by Bombyx mori." ]

[ 1999 ]

1

[]

0

null

[ "Amphiesmenoptera", "Chitinophaga agrisoli" ]

[ 83, 1 ]

2

[]

0

true

Family

Fibroin light chain

L-fibroin

2