LiteFold/InterPro · Datasets at Hugging Face

IPR008794

8,794

Proline racemase family

Pro_racemase_fam

Family

14,018

false

This family consists of proline racemase ( ), 4-hydroxyproline epimerase ( ), and trans-L-3-hydroxyproline dehydratase ( ). Proline racemase catalyses the interconversion of L- and D-proline in bacteria [ ]. Although the mechanisms of aminoacid racemisation and epimerisation are conserved between proline racemase and h...

[]

0

[ "PFAM", "PIRSF", "PANTHER", "SFLD" ]

[ "PF05544", "PIRSF029792", "PTHR33442", "SFLDS00028" ]

[ "Pro_racemase", "Pro_racemase", "", "Proline_Racemase" ]

[ 14016, 12666, 13909, 12925 ]

4

[ "EC" ]

[ "5.1.1" ]

[ "EC:5.1.1" ]

1

[ "1tm0", "1w61", "1w62", "2azp", "4j9w", "4j9x", "4jbd", "4jci", "4jd7", "4juu", "4k7g", "4k7x", "4k8l", "4lb0", "4q2h", "4q60", "6hje", "6hjf", "6hjg", "6j7c", "6r76", "6r77", "7pb3", "7qpo", "8a3f", "8a4r" ]

26

[ "PUB00011432", "PUB00067368", "PUB00067369" ]

[ "3755058", "17849014", "22528483" ]

[ "Energetics of proline racemase: racemization of unlabeled proline in the unsaturated, saturated, and oversaturated regimes.", "Molecular and structural discrimination of proline racemase and hydroxyproline-2-epimerase from nosocomial and bacterial pathogens.", "Identification of a human trans-3-hydroxy-L-proli...

[ 1986, 2007, 2012 ]

3

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 108, 10998, 2714, 198 ]

4

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 5, 4, 1, 1 ]

4

true

Family

Proline racemase family

Pro_racemase_fam

9

IPR008795

8,795

Prominin

Family

6,762

false

The prominins are an emerging family of proteins that, among the multispan membrane proteins, display a novel topology. Mouse and Homo sapiens prominin and (Mus musculus) prominin-like 1 (PROML1) are predicted to contain five membrane spanning domains, with an N-terminal domain exposed to the extracellular space follow...

[ "GO:0016020" ]

[ "membrane" ]

[ "cellular_component" ]

1

[ "PFAM", "PANTHER" ]

[ "PF05478", "PTHR22730" ]

[ "Prominin", "" ]

[ 6597, 6493 ]

2

[ "REACTOME" ]

[ "R-HSA-9925563" ]

[ "REACTOME:R-HSA-9925563" ]

1

[]

0

[ "PUB00011434", "PUB00011435" ]

[ "11467842", "10587575" ]

[ "Rat prominin, like its mouse and human orthologues, is a pentaspan membrane glycoprotein.", "A frameshift mutation in prominin (mouse)-like 1 causes human retinal degeneration." ]

[ 2001, 2000 ]

2

[]

0

null

[ "Eukaryota" ]

[ 6762 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 50, 11, 11, 14, 19 ]

6

true

Family

Prominin

7

IPR008796

8,796

Photosystem I reaction centre subunit N, chloroplastic

PSAN

Family

1,107

false

Photosystem I reaction centre subunit N (PSAN, also known as PSI-N) may function in mediating the binding of the antenna complexes to the PSI reaction centre and core antenna [ ]. PSI-N subunit does not bind pigments [ ].

[ "GO:0015979", "GO:0009522" ]

[ "photosynthesis", "photosystem I" ]

[ "biological_process", "cellular_component" ]

2

[ "PFAM", "PANTHER" ]

[ "PF05479", "PTHR36814" ]

[ "PsaN", "" ]

[ 1105, 740 ]

2

[ "GP", "GP" ]

[ "GenProp0660", "GenProp1353" ]

[ "GP:GenProp0660", "GP:GenProp1353" ]

2

[ "2o01", "2wsc", "2wse", "2wsf", "3lw5", "4rku", "5zji", "7yca", "8wgh", "9gbi", "9gc2" ]

11

[ "PUB00011436", "PUB00077043" ]

[ "10230065", "12324436" ]

[ "The interaction between plastocyanin and photosystem I is inefficient in transgenic Arabidopsis plants lacking the PSI-N subunit of photosystem I.", "Pigment organization and energy transfer dynamics in isolated photosystem I (PSI) complexes from Arabidopsis thaliana depleted of the PSI-G, PSI-K, PSI-L, or PSI-N...

[ 1999, 2002 ]

2

[]

0

null

[ "Bacteria", "Methanobacteriati", "Viridiplantae" ]

[ 10, 3, 1094 ]

3

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 4, 9, 9 ]

3

true

Family

Photosystem I reaction centre subunit N, chloroplastic

PSAN

3

IPR008797

8,797

Oxygen-evolving enhancer protein 3

PSII_PsbQ

Family

3,143

false

In PSII, the oxygen-evolving complex (OEC) is responsible for catalysing the splitting of water to O(2) and 4H+. The OEC is composed of a cluster of manganese, calcium and chloride ions bound to extrinsic proteins. In cyanobacteria there are five extrinsic proteins in OEC (PsbO, PsbP-like, PsbQ-like, PsbU and PsbV), wh...

[ "GO:0005509", "GO:0015979", "GO:0009523", "GO:0009654", "GO:0019898" ]

[ "calcium ion binding", "photosynthesis", "photosystem II", "photosystem II oxygen evolving complex", "extrinsic component of membrane" ]

[ "molecular_function", "biological_process", "cellular_component", "cellular_component", "cellular_component" ]

5

[ "PFAM" ]

[ "PF05757" ]

[ "PsbQ" ]

[ 3143 ]

1

[]

0

[ "1nze", "1vyk", "2mwq", "3jcu", "3ls0", "3ls1", "3zsu", "4yuu", "5xnl", "6kac", "7eu3", "7f9o", "7n8o", "7rcv", "7wff", "7wg5", "7y5e", "7y7a", "8bd3", "8iwh", "8tow", "8wql", "8z9d", "9eh5", "9grx", "9hd7", "9phw" ]

27

[ "PUB00015357", "PUB00015358", "PUB00015359", "PUB00015369", "PUB00015372", "PUB00097583", "PUB00152828" ]

[ "12518057", "15100025", "14871485", "15258264", "12949587", "30076221", "33846594" ]

[ "Crystal structure of oxygen-evolving photosystem II from Thermosynechococcus vulcanus at 3.7-A resolution.", "The evolutionary development of the protein complement of photosystem 2.", "The low molecular mass subunits of the photosynthetic supracomplex, photosystem II.", "Homologs of plant PsbP and PsbQ prot...

[ 2003, 2004, 2004, 2004, 2003, 2018, 2021 ]

7

[]

[ "IPR017487", "IPR054099" ]

0

2

0

[ "Bacteria", "Eukaryota" ]

[ 315, 2828 ]

2

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 18, 16, 34 ]

3

true

Family

Oxygen-evolving enhancer protein 3

PSII_PsbQ

5

IPR008798

8,798

Avirulence B/C

Avirulence_B/C

Family

125

false

This entry represents the avirulence B and C proteins from Pseudomonas syringae [ ] and related proteins from Xanthomonas campestris [ ]. avrB and avrC encode these proteins, which are 36 and 39 kilodaltons in size respectively [ ]. Pathogenic bacterial effectors suppress pathogen-associated molecular pattern (PAMP)-tr...

[]

0

[ "PFAM" ]

[ "PF05394" ]

[ "AvrB_AvrC" ]

[ 125 ]

1

[]

0

[ "1nh1", "2nud", "2nun", "8twj", "8two", "8tws", "8txf" ]

7

[ "PUB00019188", "PUB00035634", "PUB00043414" ]

[ "3049552", "12024217", "17148606" ]

[ "Characterization and expression of two avirulence genes cloned from Pseudomonas syringae pv. glycinea.", "Comparison of the genomes of two Xanthomonas pathogens with differing host specificities.", "RAR1, a central player in plant immunity, is targeted by Pseudomonas syringae effector AvrB." ]

[ 1988, 2002, 2006 ]

3

[]

0

null

[ "Bacteria", "Eutreptiella gymnastica" ]

[ 124, 1 ]

2

[]

0

true

Family

Avirulence B/C

Avirulence_B/C

4

IPR008799

8,799

Pseudomonas avirulence D

Pseudomon_AvrD

Family

426

false

This family consists of several avirulence D (AvrD) proteins primarily found in Pseudomonas syringae [ ].

[]

0

[ "PFAM" ]

[ "PF05655" ]

[ "AvrD" ]

[ 426 ]

1

[]

0

[]

0

[ "PUB00011663" ]

[ "10485919" ]

[ "Identification of a pathogenicity island, which contains genes for virulence and avirulence, on a large native plasmid in the bean pathogen Pseudomonas syringae pathovar phaseolicola." ]

[ 1999 ]

1

[]

0

null

[ "Bacteria" ]

[ 426 ]

1

[]

0

true

Family

Pseudomonas avirulence D

Pseudomon_AvrD

8

IPR008800

8,800

PufQ cytochrome subunit

PufQ_cyt-su

Family

194

false

This family consists of bacterial PufQ proteins. PufQ is required for bacteriochlorophyll biosynthesis serving a regulatory function in the formation of photosynthetic complexes [ ].

[ "GO:0015979", "GO:0030494" ]

[ "photosynthesis", "bacteriochlorophyll biosynthetic process" ]

[ "biological_process", "biological_process" ]

2

[ "PFAM", "PIRSF" ]

[ "PF05398", "PIRSF005825" ]

[ "PufQ", "PufQ" ]

[ 194, 111 ]

2

[]

0

[]

0

[ "PUB00011438" ]

[ "10196154" ]

[ "A new cytochrome subunit bound to the photosynthetic reaction center in the purple bacterium, Rhodovulum sulfidophilum." ]

[ 1999 ]

1

[]

0

null

[ "Ciona savignyi", "Pseudomonadota" ]

[ 1, 193 ]

2

[]

0

true

Family

PufQ cytochrome subunit

PufQ_cyt-su

8

IPR008801

8,801

Rapid ALkalinization Factor

RALF

Family

7,169

false

The plant RAPID ALKALINIZATION FACTOR (RALF) family consists of extracellular peptides that serve as extracellular signals. RALF1, a 5kDa ubiquitous polypeptide in plants, arrests root growth and development [ , ]. RALF4/19 peptides interact with LRX proteins to control pollen tube growth [ ].

[]

0

[ "PFAM" ]

[ "PF05498" ]

[ "RALF" ]

[ 7169 ]

1

[]

0

[ "6a5e", "6nu4", "6qwn", "6qxp", "6tme" ]

5

[ "PUB00089363", "PUB00089364", "PUB00089366" ]

[ "29282286", "29242232", "11675511" ]

[ "Arabidopsis thaliana rapid alkalinization factor 1-mediated root growth inhibition is dependent on calmodulin-like protein 38.", "RALF4/19 peptides interact with LRX proteins to control pollen tube growth in Arabidopsis.", "RALF, a 5-kDa ubiquitous polypeptide in plants, arrests root growth and development." ]

[ 2018, 2017, 2001 ]

3

[]

[ "IPR039252" ]

0

1

0

[ "Bacteria", "Eukaryota" ]

[ 15, 7154 ]

2

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 107, 35, 54 ]

3

true

Family

Rapid ALkalinization Factor

RALF

4

IPR008803

8,803

RHD3/Sey1

Family

5,568

false

This family consists of plant root hair defective 3 (RHD3) protein and its homologues from other eukaryotes. RHD3 is a conserved protein with GTP-binding motifs that is implicated in the control of vesicle trafficking between the endoplasmic reticulum and the Golgi compartments [ ] and is also involved in homotypic ER ...

[]

0

[ "HAMAP", "PANTHER" ]

[ "MF_03109", "PTHR45923" ]

[ "Sey1", "" ]

[ 3253, 5566 ]

2

[ "EC" ]

[ "3.6.5.-" ]

[ "EC:3.6.5.-" ]

1

[ "5ca8", "5ca9", "5cb2" ]

3

[ "PUB00011441", "PUB00053138", "PUB00064782", "PUB00064783", "PUB00098270" ]

[ "9087433", "19665976", "12068108", "12844267", "26370501" ]

[ "The ROOT HAIR DEFECTIVE3 gene encodes an evolutionarily conserved protein with GTP-binding motifs and is required for regulated cell enlargement in Arabidopsis.", "A class of dynamin-like GTPases involved in the generation of the tubular ER network.", "Regulation of the cell expansion gene RHD3 during Arabidop...

[ 1997, 2009, 2002, 2003, 2015 ]

5

[]

0

null

[ "Eukaryota" ]

[ 5568 ]

1

[ "Arabidopsis thaliana", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)", "Zea mays" ]

[ 14, 1, 7, 1, 1, 59 ]

6

true

Family

RHD3/Sey1

2

IPR008806

8,806

RNA polymerase III Rpc82, C -terminal

RNA_pol_III_Rpc82_C

Domain

4,217

false

DNA-directed RNA polymerases (also known as DNA-dependent RNA polymerases) are responsible for the polymerisation of ribonucleotides into a sequence complementary to the template DNA. In eukaryotes, there are three different forms of DNA-directed RNA polymerases transcribing different sets of genes. Most RNA polymerase...

[ "GO:0003677", "GO:0006351" ]

[ "DNA binding", "DNA-templated transcription" ]

[ "molecular_function", "biological_process" ]

2

[ "PFAM" ]

[ "PF05645" ]

[ "RNA_pol_Rpc82" ]

[ 4217 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-76061", "R-BTA-76066", "R-BTA-76071", "R-HSA-1834949", "R-HSA-73780", "R-HSA-73980", "R-HSA-749476", "R-HSA-76061", "R-HSA-76066", "R-HSA-76071", "R-MMU-76061", "R-MMU-76066", "R-MMU-76071", "R-RNO-76061", "R-RNO-76066", "R-RNO-76071", "R-SCE-76066", "R-SPO-76061", "R-SPO-...

[ "REACTOME:R-BTA-76061", "REACTOME:R-BTA-76066", "REACTOME:R-BTA-76071", "REACTOME:R-HSA-1834949", "REACTOME:R-HSA-73780", "REACTOME:R-HSA-73980", "REACTOME:R-HSA-749476", "REACTOME:R-HSA-76061", "REACTOME:R-HSA-76066", "REACTOME:R-HSA-76071", "REACTOME:R-MMU-76061", "REACTOME:R-MMU-76066", "...

19

[ "2xub", "2xv4", "5afq", "5fj8", "5fj9", "5fja", "6cnb", "6cnc", "6cnd", "6cnf", "6eu0", "6eu1", "6eu2", "6eu3", "6f40", "6f41", "6f42", "6f44", "6tut", "7a6h", "7ae1", "7ae3", "7aea", "7ast", "7d58", "7d59", "7dn3", "7du2", "7fji", "7fjj", "7z0h", "7z1l"...

57

[ "PUB00000061", "PUB00011444", "PUB00033173" ]

[ "3052291", "1406632", "10499798" ]

[ "Structure and function of bacterial sigma factors.", "RPC82 encodes the highly conserved, third-largest subunit of RNA polymerase C (III) from Saccharomyces cerevisiae.", "Crystal structure of Thermus aquaticus core RNA polymerase at 3.3 A resolution." ]

[ 1988, 1992, 1999 ]

3

[]

0

null

[ "Eukaryota", "Neobacillus kokaensis" ]

[ 4216, 1 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 7, 1, 6, 1, 7, 3, 1, 5, 3, 1, 1, 7 ]

12

true

Domain

RNA polymerase III Rpc82, C -terminal

RNA_pol_III_Rpc82_C

9

IPR008807

8,807

ROS/MUCR transcriptional regulator

ROS_MUCR

Family

6,559

false

This family consists of several ROS/MUCR transcriptional regulator proteins. The ros chromosomal gene is present in octopine and nopaline strains of Agrobacterium tumefaciens as well as in Rhizobium meliloti (Sinorhizobium meliloti). This gene encodes a 15.5kDa protein that specifically represses the virC and virD oper...

[ "GO:0003677", "GO:0008270", "GO:0006355" ]

[ "DNA binding", "zinc ion binding", "regulation of DNA-templated transcription" ]

[ "molecular_function", "molecular_function", "biological_process" ]

3

[ "PFAM" ]

[ "PF05443" ]

[ "ROS_MUCR" ]

[ 6559 ]

1

[]

0

[ "2jsp" ]

1

[ "PUB00011445", "PUB00011446", "PUB00011447" ]

[ "2013576", "7756693", "10656595" ]

[ "The virC and virD operons of the Agrobacterium Ti plasmid are regulated by the ros chromosomal gene: analysis of the cloned ros gene.", "Molecular analysis of the Rhizobium meliloti mucR gene regulating the biosynthesis of the exopolysaccharides succinoglycan and galactoglucan.", "MucR is necessary for galacto...

[ 1991, 1995, 2000 ]

3

[]

0

null

[ "Bacteria", "Caudoviricetes", "Eukaryota", "Methanobacteriota", "metagenomes" ]

[ 6485, 8, 12, 14, 40 ]

5

[]

0

true

Family

ROS/MUCR transcriptional regulator

ROS_MUCR

7

IPR008808

8,808

Powdery mildew resistance protein, RPW8 domain

Powdery_mildew-R_dom

Domain

3,122

false

This entry represents the RPW8 domain found in several broad-spectrum mildew resistance proteins from Arabidopsis thaliana and other dicots. Plant disease resistance (R) genes control the recognition of specific pathogens and activate subsequent defence responses. The R protein-mediated defences typically involve a rap...

[]

0

[ "PFAM", "PROFILE" ]

[ "PF05659", "PS51153" ]

[ "RPW8", "RPW8" ]

[ 2999, 2795 ]

2

[]

0

[ "7l7v", "7l7w", "8yl6", "8zf0", "8zw9", "8zwa", "9jbn" ]

7

[ "PUB00011557", "PUB00033612" ]

[ "11141561", "15155802" ]

[ "Broad-spectrum mildew resistance in Arabidopsis thaliana mediated by RPW8.", "Origin and maintenance of a broad-spectrum disease resistance locus in Arabidopsis." ]

[ 2001, 2004 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "Haloferacaceae" ]

[ 7, 3111, 4 ]

3

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 106, 1, 5 ]

3

true

Domain

Powdery mildew resistance protein, RPW8 domain

Powdery_mildew-R_dom

3

IPR008810

8,810

Rhodococcus equi virulence-associated protein

R_equi_Vir

Family

288

false

This family consists of several virulence-associated proteins, mainly from Corynebacterium equii (Rhodococcus equi, Rhodococcus hoagii). R. equi is an important pulmonary pathogen of foals and is increasingly isolated from pneumonic infections and other infections in Homo sapiens immunodeficiency virus-infected patient...

[]

0

[ "PFAM", "PIRSF" ]

[ "PF05526", "PIRSF009221" ]

[ "R_equi_Vir", "R_equi_Vir" ]

[ 288, 43 ]

2

[]

0

[ "4csb", "4cv7", "5aeo", "7b1z" ]

4

[ "PUB00011449", "PUB00088269", "PUB00088270", "PUB00088271" ]

[ "11083803", "29205554", "18606735", "25895973" ]

[ "DNA sequence and comparison of virulence plasmids from Rhodococcus equi ATCC 33701 and 103.", "VapA of Rhodococcus equi binds phosphatidic acid.", "Evolution of the Rhodococcus equi vap pathogenicity island seen through comparison of host-associated vapA and vapB virulence plasmids.", "An Invertron-Like Line...

[ 2000, 2018, 2008, 2015 ]

4

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 197, 89, 2 ]

3

[]

0

true

Family

Rhodococcus equi virulence-associated protein

R_equi_Vir

1

IPR008811

8,811

Glycosyl hydrolases 36

Glycosyl_hydrolases_36

Family

7,751

false

This family consists of several galactinol-sucrose galactosyltransferase proteins, also known as raffinose synthases, which is a widespread oligosaccharide in plant seeds and other tissues. Raffinose synthase ( ) is the key enzyme that channels sucrose into the raffinose oligosaccharide pathway [ ]. Raffinose family ol...

[]

0

[ "PFAM", "PANTHER" ]

[ "PF05691", "PTHR31268" ]

[ "Raffinose_syn", "" ]

[ 7741, 7466 ]

2

[ "EC", "METACYC", "METACYC", "METACYC" ]

[ "2.4.1.82", "PWY-5337", "PWY-6524", "PWY-6525" ]

[ "EC:2.4.1.82", "METACYC:PWY-5337", "METACYC:PWY-6524", "METACYC:PWY-6525" ]

4

[ "7exf", "7exg", "7exh", "7exj", "7exq", "7exr" ]

6

[ "PUB00011450", "PUB00066767", "PUB00066768" ]

[ "12244450", "18335235", "21639842" ]

[ "Functional expression of a cDNA encoding pea (Pisum sativum L.) raffinose synthase, partial purification of the enzyme from maturing seeds, and steady-state kinetic analysis of raffinose synthesis.", "Enzymatic breakdown of raffinose oligosaccharides in pea seeds.", "Hierarchical classification of glycoside hy...

[ 2002, 2008, 2011 ]

3

[]

0

null

[ "Bacteria", "Eukaryota", "Thermoprotei", "marine sediment metagenome" ]

[ 366, 7332, 51, 2 ]

4

[ "Arabidopsis thaliana", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 30, 1, 37, 72 ]

4

true

Family

Glycosyl hydrolases 36

Glycosyl_hydrolases_36

8

IPR008812

8,812

GTP-binding nuclear protein Ran-related

Ran_GTP-bd-rel

Family

1,361

false

The small Ras-like GTPase Ran plays an essential role in the transport of macromolecules in and out of the nucleus and has been implicated in spindle and nuclear envelope formation during mitosis in higher eukaryotes. The Saccharomyces cerevisiae ORF YGL164c encoding a novel RanGTP-binding protein, termed Yrb30p was id...

[]

0

[ "PFAM", "PANTHER" ]

[ "PF05508", "PTHR31010" ]

[ "Ran-binding", "" ]

[ 1348, 1345 ]

2

[]

0

[]

0

[ "PUB00011451" ]

[ "12578832" ]

[ "Identification and characterization of a novel RanGTP-binding protein in the yeast Saccharomyces cerevisiae." ]

[ 2003 ]

1

[]

0

null

[ "Eukaryota" ]

[ 1361 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 1, 2 ]

3

true

Family

GTP-binding nuclear protein Ran-related

Ran_GTP-bd-rel

5

IPR008813

8,813

Plasmid replication protein, RepL

Plasmid_replication_RepL

Domain

1,405

false

This entry consists of proteins thought to be involved in plasmid replication.

[ "GO:0006260", "GO:0006276" ]

[ "DNA replication", "plasmid maintenance" ]

[ "biological_process", "biological_process" ]

2

[ "PFAM" ]

[ "PF05732" ]

[ "RepL" ]

[ 1405 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Caudoviricetes", "Eukaryota", "unclassified sequences" ]

[ 4, 1326, 14, 11, 50 ]

5

[]

0

true

Domain

Plasmid replication protein, RepL

Plasmid_replication_RepL

4

IPR008814

8,814

Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit Swp1

Swp1

Family

5,609

false

Swp1 is an essential subunit of the N-oligosaccharyl transferase (OST) complex which catalyses the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains [ ]. N-glycosylation occurs cotranslation...

[ "GO:0008250", "GO:0016020" ]

[ "oligosaccharyltransferase complex", "membrane" ]

[ "cellular_component", "cellular_component" ]

2

[ "PANTHER" ]

[ "PTHR12640" ]

[ "" ]

[ 5609 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-1799339", "R-HSA-446203", "R-HSA-9694548", "R-HSA-9768727", "R-MMU-9768727", "R-RNO-9768727" ]

[ "REACTOME:R-HSA-1799339", "REACTOME:R-HSA-446203", "REACTOME:R-HSA-9694548", "REACTOME:R-HSA-9768727", "REACTOME:R-MMU-9768727", "REACTOME:R-RNO-9768727" ]

6

[ "6c26", "6ezn", "6s7o", "6s7t", "7oci", "8agb", "8agc", "8age", "8b6l", "8pn9" ]

10

[ "PUB00054184", "PUB00054186" ]

[ "15831493", "8175708" ]

[ "Subunits of the translocon interact with components of the oligosaccharyl transferase complex.", "The Saccharomyces cerevisiae oligosaccharyltransferase is a protein complex composed of Wbp1p, Swp1p, and four additional polypeptides." ]

[ 2005, 1994 ]

2

[]

0

null

[ "Eukaryota" ]

[ 5609 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 6, 1, 2, 2, 8, 4, 1, 2, 8, 1, 1, 24 ]

12

true

Family

Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit Swp1

Swp1

7

IPR008816

8,816

Glycine zipper 2TM domain

Gly_zipper_2TM_dom

Domain

15,184

false

This domain includes a putative transmembrane region, composed of two α-helices, that contains glycine zipper motifs [ ]. Most members of this group of proteins are found in Proteobacteria, including several Rickettsia genus specific 17kDa surface antigen proteins [ ].

[ "GO:0019867" ]

[ "outer membrane" ]

[ "cellular_component" ]

1

[ "PFAM" ]

[ "PF05433" ]

[ "Rick_17kDa_Anti" ]

[ 15184 ]

1

[]

0

[ "7ojf", "7ojg" ]

2

[ "PUB00020255", "PUB00055608" ]

[ "3139629", "16179394" ]

[ "Expression of the gene encoding the 17-kilodalton antigen from Rickettsia rickettsii: transcription and posttranslational modification.", "Transmembrane glycine zippers: physiological and pathological roles in membrane proteins." ]

[ 1988, 2005 ]

2

[]

0

null

[ "Archaea", "Bacteria", "Caudoviricetes", "Eukaryota", "unclassified sequences" ]

[ 43, 13794, 10, 1255, 82 ]

5

[ "Escherichia coli (strain K12)", "Oryza sativa subsp. japonica", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Zea mays" ]

[ 3, 1, 1, 9 ]

4

true

Domain

Glycine zipper 2TM domain

Gly_zipper_2TM_dom

9

IPR008818

8,818

Rotavirus major outer capsid VP7

Rotavirus_VP7

Family

439

false

This family consists of several Rotavirus major outer capsid protein VP7 sequences. The rotavirus capsid is composed of three concentric protein layers. Proteins VP4 and VP7 comprise the outer layer. VP4 forms spikes and is the viral attachment protein. VP7 is a glycoprotein and the major constituent of the outer prote...

[ "GO:0016020", "GO:0044423" ]

[ "membrane", "virion component" ]

[ "cellular_component", "cellular_component" ]

2

[ "PFAM" ]

[ "PF05868" ]

[ "Rotavirus_VP7" ]

[ 439 ]

1

[]

0

[]

0

[ "PUB00011453" ]

[ "12050377" ]

[ "Antibodies to rotavirus outer capsid glycoprotein VP7 neutralize infectivity by inhibiting virion decapsidation." ]

[ 2002 ]

1

[]

0

null

[ "Riboviria" ]

[ 439 ]

1

[]

0

true

Family

Rotavirus major outer capsid VP7

Rotavirus_VP7

6

IPR008819

8,819

Rubella capsid

Rubella_Capsid

Family

110

false

Rubella virus is an enveloped positive-strand RNA virus of the family Togaviridae. Virions are composed of three structural proteins: a capsid and two membrane-spanning glycoproteins, E2 and E1. During virus assembly, the capsid interacts with genomic RNA to form nucleocapsids. It has been discovered that capsid phosph...

[ "GO:0016020", "GO:0019013" ]

[ "membrane", "viral nucleocapsid" ]

[ "cellular_component", "cellular_component" ]

2

[ "PFAM" ]

[ "PF05750" ]

[ "Rubella_Capsid" ]

[ 110 ]

1

[]

0

[ "4har", "4hbe", "4hbo", "5khe", "5khf" ]

5

[ "PUB00011454" ]

[ "12525610" ]

[ "Phosphorylation of rubella virus capsid regulates its RNA binding activity and virus replication." ]

[ 2003 ]

1

[]

0

null

[ "Matonaviridae" ]

[ 110 ]

1

[]

0

true

Family

Rubella capsid

Rubella_Capsid

5

IPR008820

8,820

Rubella membrane glycoprotein E1

Rubella_E1

Family

2,947

false

Rubella virus (RV), the sole member of the genus Rubivirus within the family Togaviridae, is a small enveloped, positive strand RNA virus. The nucleocapsid consists of 40S genomic RNA and a single species of capsid protein which is enveloped within a host-derived lipid bilayer containing two viral glycoproteins, E1 (58...

[ "GO:0016020", "GO:0019013" ]

[ "membrane", "viral nucleocapsid" ]

[ "cellular_component", "cellular_component" ]

2

[ "PFAM" ]

[ "PF05748" ]

[ "Rubella_E1" ]

[ 2947 ]

1

[]

0

[ "4adg", "4adi", "4adj", "4b3v", "5khc" ]

5

[ "PUB00011455" ]

[ "11682134" ]

[ "Effect of site-directed asparagine to isoleucine substitutions at the N-linked E1 glycosylation sites on rubella virus viability." ]

[ 2001 ]

1

[]

0

null

[ "Matonaviridae" ]

[ 2947 ]

1

[]

0

true

Family

Rubella membrane glycoprotein E1

Rubella_E1

9

IPR008821

8,821

Rubella membrane glycoprotein E2

Rubella_E2

Domain

133

false

Rubella virus (RV), the sole member of the genus Rubivirus within the family Togaviridae, is a small enveloped, positive strand RNA virus. The nucleocapsid consists of 40S genomic RNA and a single species of capsid protein which is enveloped within a host-derived lipid bilayer containing two viral glycoproteins, E1 (58...

[ "GO:0016020", "GO:0019013" ]

[ "membrane", "viral nucleocapsid" ]

[ "cellular_component", "cellular_component" ]

2

[ "PFAM" ]

[ "PF05749" ]

[ "Rubella_E2" ]

[ 133 ]

1

[]

0

[]

0

[ "PUB00011455" ]

[ "11682134" ]

[ "Effect of site-directed asparagine to isoleucine substitutions at the N-linked E1 glycosylation sites on rubella virus viability." ]

[ 2001 ]

1

[]

0

null

[ "Rubivirus" ]

[ 133 ]

1

[]

0

true

Domain

Rubella membrane glycoprotein E2

Rubella_E2

5

IPR008822

8,822

Holliday junction resolvase RusA-like

Endonuclease_RusA-like

Family

6,631

false

This family consists of several bacterial and phage Holliday junction resolvase (RusA) like proteins. The RusA protein of Escherichia coli is an endonuclease that can resolve Holliday intermediates and correct the defects in genetic recombination and DNA repair associated with inactivation of RuvAB or RuvC [ ].

[ "GO:0000287", "GO:0006281", "GO:0006310" ]

[ "magnesium ion binding", "DNA repair", "DNA recombination" ]

[ "molecular_function", "biological_process", "biological_process" ]

3

[ "PFAM" ]

[ "PF05866" ]

[ "RusA" ]

[ 6631 ]

1

[ "EC" ]

[ "3.1.21.10" ]

[ "EC:3.1.21.10" ]

1

[ "1q8r", "2h8c", "2h8e" ]

3

[ "PUB00011651" ]

[ "7813450" ]

[ "Processing of intermediates in recombination and DNA repair: identification of a new endonuclease that specifically cleaves Holliday junctions." ]

[ 1994 ]

1

[]

[ "IPR016281" ]

0

1

0

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 21, 5530, 75, 782, 223 ]

5

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Holliday junction resolvase RusA-like

Endonuclease_RusA-like

7

IPR008823

8,823

RuvB, winged helix, C-terminal domain

RuvB_wg_C

Domain

25,403

false

This entry represents the C-terminal region of the RuvB protein which is thought to be an helicase DNA-binding domain. The RuvB protein makes up part of the RuvABC resolvasome which catalyses the resolution of Holliday junctions that arise during genetic recombination and DNA repair. Branch migration is catalysed by th...

[ "GO:0003677", "GO:0009378", "GO:0006281", "GO:0006310" ]

[ "DNA binding", "four-way junction helicase activity", "DNA repair", "DNA recombination" ]

[ "molecular_function", "molecular_function", "biological_process", "biological_process" ]

4

[ "PFAM" ]

[ "PF05491" ]

[ "WHD_RuvB" ]

[ 25403 ]

1

[ "EC", "METACYC" ]

[ "3.6.4.-", "PWY-7250" ]

[ "EC:3.6.4.-", "METACYC:PWY-7250" ]

2

[ "1hqc", "1in4", "1in5", "1in6", "1in7", "1in8", "1ixr", "1ixs", "1j7k", "3pfi", "6blb", "7pbl", "7pbm", "7pbn", "7pbo", "7pbp", "7pbq", "7pbr", "7pbs", "7pbt", "7x5b", "7x7p", "7x7q", "8efv", "8efy" ]

25

[ "PUB00011456" ]

[ "12423347" ]

[ "The RuvABC resolvasome." ]

[ 2002 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "Methanobacteriota", "unclassified Caudoviricetes", "unclassified sequences" ]

[ 24685, 60, 46, 3, 609 ]

5

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Domain

RuvB, winged helix, C-terminal domain

RuvB_wg_C

7

IPR008824

8,824

RuvB-like, AAA+ ATPase domain

RuvB-like_N

Domain

27,431

false

This entry represents the N-terminal domain of RuvB-like proteins. It adotps a Rossman fold (αβα sandwich). The RuvB protein makes up part of the RuvABC resolvasome which catalyses the resolution of Holliday junctions that arise during genetic recombination and DNA repair. Branch migration is catalysed by the RuvB prot...

[ "GO:0009378", "GO:0006281", "GO:0006310" ]

[ "four-way junction helicase activity", "DNA repair", "DNA recombination" ]

[ "molecular_function", "biological_process", "biological_process" ]

3

[ "PFAM" ]

[ "PF05496" ]

[ "RuvB_N" ]

[ 27431 ]

1

[ "EC", "METACYC" ]

[ "3.6.4.-", "PWY-7250" ]

[ "EC:3.6.4.-", "METACYC:PWY-7250" ]

2

[ "1hqc", "1in4", "1in5", "1in6", "1in7", "1in8", "1ixr", "1ixs", "1j7k", "3pfi", "6blb", "7pbl", "7pbm", "7pbn", "7pbo", "7pbp", "7pbq", "7pbr", "7pbs", "7pbt", "7x5b", "7x7p", "7x7q", "8efv", "8efy" ]

25

[ "PUB00011456", "PUB00057226" ]

[ "12423347", "11473577" ]

[ "The RuvABC resolvasome.", "AAA+ superfamily ATPases: common structure--diverse function." ]

[ 2002, 2001 ]

2

[ "IPR003593" ]

[]

1

0

1

[ "Archaea", "Bacteria", "Caudoviricetes", "Eukaryota", "unclassified sequences" ]

[ 56, 26495, 4, 161, 715 ]

5

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Domain

RuvB-like, AAA+ ATPase domain

RuvB-like_N

8

IPR008825

8,825

S-antigen

Domain

94

false

This domain is found at the N terminus of S-antigen proteins from Plasmodium falciparum. S-antigens are heat stable proteins that are found in the blood of individuals infected with malaria [ ].

[]

0

[ "PFAM" ]

[ "PF05756" ]

[ "S-antigen" ]

[ 94 ]

1

[]

0

[]

0

[ "PUB00020286" ]

[ "779155" ]

[ "Persistence and recurrence of S-antigen in Plasmodium falciparum infections in man." ]

[ 1975 ]

1

[]

0

null

[ "Plasmodium" ]

[ 94 ]

1

[]

0

true

Domain

S-antigen

6

IPR008826

8,826

Selenium-binding protein

Se-bd

Family

5,865

false

This family consists of selenium binding proteins from eukaryotes, bacteria and archaea. Human selenium-binding protein 1 (SELENBP1) is a methanethiol oxidase (MTO) that converts methanethiol to H2O2, formaldehyde, and H2S [ ]. Bovine SBP56 has been shown to participate in late stages of intra-Golgi protein transport [...

[ "GO:0008430" ]

[ "selenium binding" ]

[ "molecular_function" ]

1

[ "PFAM", "PANTHER" ]

[ "PF05694", "PTHR23300" ]

[ "SBP56", "" ]

[ 5863, 5786 ]

2

[ "EC", "METACYC" ]

[ "1.8.3.4", "PWY-6047" ]

[ "EC:1.8.3.4", "METACYC:PWY-6047" ]

2

[ "2ece" ]

1

[ "PUB00011458", "PUB00011459", "PUB00088397" ]

[ "10799528", "12026169", "29255262" ]

[ "A 56-kDa selenium-binding protein participates in intra-Golgi protein transport.", "Lotus japonicus gene Ljsbp is highly conserved among plants and animals and encodes a homologue to the mammalian selenium-binding proteins.", "Mutations in SELENBP1, encoding a novel human methanethiol oxidase, cause extraoral ...

[ 2000, 2002, 2018 ]

3

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "ecological metagenomes" ]

[ 194, 1563, 4105, 3 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 12, 3, 2, 8, 9, 7, 2, 5, 27 ]

9

true

Family

Selenium-binding protein

Se-bd

5

IPR008828

8,828

TORC2 component Sin1/Avo1

Sin1/Avo1

Family

4,259

false

This entry includes MAPKAP1/Sin1 from animals, Sin1 from fission yeast, Avo1 from budding yeast and Rip3 from Slime mold. They are part of the Target Of Rapamycin Complex 2 (TORC2) complex, which plays an essential role in signal transduction [ ]. The mammalian TORC2 consists of mTOR, MLST8, PRR5, RICTOR, MAPKAP1 and D...

[ "GO:0031932" ]

[ "TORC2 complex" ]

[ "cellular_component" ]

1

[ "PANTHER" ]

[ "PTHR13335" ]

[ "" ]

[ 4259 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-CEL-1257604", "R-CEL-389357", "R-CEL-5218920", "R-CEL-6804757", "R-CEL-9856530", "R-DDI-1257604", "R-DDI-389357", "R-DDI-5218920", "R-DDI-6804757", "R-DDI-9856530", "R-DME-1257604", "R-DME-389357", "R-DME-5218920", "R-DME-9856530", "R-GGA-1257604", "R-GGA-389357", "R-GGA-5218920",...

[ "REACTOME:R-CEL-1257604", "REACTOME:R-CEL-389357", "REACTOME:R-CEL-5218920", "REACTOME:R-CEL-6804757", "REACTOME:R-CEL-9856530", "REACTOME:R-DDI-1257604", "REACTOME:R-DDI-389357", "REACTOME:R-DDI-5218920", "REACTOME:R-DDI-6804757", "REACTOME:R-DDI-9856530", "REACTOME:R-DME-1257604", "REACTOME:...

45

[ "2ruj", "2rvk", "3ulb", "3ulc", "3voq", "5zcs", "6emk", "6zwm", "6zwo", "7lc1", "7lc2", "7pe7", "7pe8", "7pe9", "7tzo", "7vv8", "7vv9", "7vvb", "7vvg" ]

19

[ "PUB00057948", "PUB00061649", "PUB00075519", "PUB00075520", "PUB00075521", "PUB00075523", "PUB00075524", "PUB00078108" ]

[ "16962653", "15689497", "15988011", "16919458", "23762398", "17043309", "17303383", "26700129" ]

[ "SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity.", "The pleckstrin homology domain proteins Slm1 and Slm2 are required for actin cytoskeleton organization in yeast and bind phosphatidylinositol-4,5-bisphosphate and TORC2.", "Mip1, an MEKK2-interacti...

[ 2006, 2005, 2005, 2006, 2013, 2006, 2007, 2015 ]

8

[]

0

null

[ "Carboxylicivirga linearis", "Eukaryota" ]

[ 1, 4258 ]

2

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strai...

[ 1, 1, 1, 10, 3, 1, 6, 1, 1 ]

9

true

Family

TORC2 component Sin1/Avo1

Sin1/Avo1

2

IPR008829

8,829

SepSecS/SepCysS family

SepSecS/SepCysS

Family

2,609

false

Early annotation suggested this family, SepSecS, of several eukaryotic and archaeal proteins, was involved in antigen-antibodies responses in the liver and pancreas [ , ]. Structural studies show that the family is O-phosphoseryl-tRNA(Sec) selenium transferase, an enzyme involved in the synthesis of the amino acid sele...

[ "GO:0016740" ]

[ "transferase activity" ]

[ "molecular_function" ]

1

[ "PFAM" ]

[ "PF05889" ]

[ "SepSecS" ]

[ 2609 ]

1

[ "EC", "METACYC", "REACTOME" ]

[ "2.5.1.73", "PWY-6308", "R-HSA-2408557" ]

[ "EC:2.5.1.73", "METACYC:PWY-6308", "REACTOME:R-HSA-2408557" ]

3

[ "2e7i", "2e7j", "2z67", "3bc8", "3bca", "3bcb", "3hl2", "3wkr", "3wks", "4zdl", "4zdo", "4zdp", "5x6b", "7l1t", "7mdl", "8g9z" ]

16

[ "PUB00011462", "PUB00011464", "PUB00043198", "PUB00050209", "PUB00050582", "PUB00061375", "PUB00075686", "PUB00075690" ]

[ "10801173", "11481605", "17512006", "18158303", "18093968", "19608919", "17194211", "18559341" ]

[ "Identification of target antigen for SLA/LP autoantibodies in autoimmune hepatitis.", "A bioinformatical approach suggests the function of the autoimmune hepatitis target antigen soluble liver antigen/liver pancreas.", "Structural insights into the second step of RNA-dependent cysteine biosynthesis in archaea:...

[ 2000, 2001, 2007, 2008, 2008, 2009, 2007, 2008 ]

8

[]

[ "IPR013375", "IPR019872" ]

0

2

0

[ "Archaea", "Eukaryota", "Myoviridae sp. ct4yW2", "ecological metagenomes" ]

[ 296, 2291, 1, 21 ]

4

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 1, 4, 6, 3, 2 ]

6

true

Family

SepSecS/SepCysS family

SepSecS/SepCysS

5

IPR008831

8,831

Mediator complex, subunit Med31

Mediator_Med31

Family

4,350

false

The Mediator complex is a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. The Mediator complex, having a compact confor...

[ "GO:0003712", "GO:0006355", "GO:0016592" ]

[ "transcription coregulator activity", "regulation of DNA-templated transcription", "mediator complex" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PFAM", "PANTHER" ]

[ "PF05669", "PTHR13186" ]

[ "Med31", "" ]

[ 4314, 4139 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-212436", "R-BTA-9841922", "R-DME-9841922", "R-HSA-1989781", "R-HSA-212436", "R-HSA-381340", "R-HSA-9833110", "R-HSA-9841922" ]

[ "REACTOME:R-BTA-212436", "REACTOME:R-BTA-9841922", "REACTOME:R-DME-9841922", "REACTOME:R-HSA-1989781", "REACTOME:R-HSA-212436", "REACTOME:R-HSA-381340", "REACTOME:R-HSA-9833110", "REACTOME:R-HSA-9841922" ]

8

[ "3fbi", "3fbn", "5n9j", "5oqm", "5sva", "5u0p", "5u0s", "6w1s", "6xp5", "7emf", "7ena", "7enc", "7enj", "7lbm", "7nvr", "7ui9", "7uif", "7uig", "7uio", "8cen", "8ceo", "8gxq", "8gxs", "8t1i", "8t1l", "8t9d", "8tqw", "8trh" ]

28

[ "PUB00011465", "PUB00011466", "PUB00051921" ]

[ "7982575", "8849885", "19057509" ]

[ "Characterization of mutations that suppress the temperature-sensitive growth of the hpr1 delta mutant of Saccharomyces cerevisiae.", "Mutations in the RNA polymerase II transcription machinery suppress the hyperrecombination mutant hpr1 delta of Saccharomyces cerevisiae.", "Identification, structure, and funct...

[ 1994, 1996, 2009 ]

3

[]

0

null

[ "Eukaryota" ]

[ 4350 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 4, 1, 1, 4, 3, 1, 1, 5, 2, 1, 1, 6 ]

12

true

Family

Mediator complex, subunit Med31

Mediator_Med31

6

IPR008832

8,832

Signal recognition particle SRP9

SRP9

Family

1,752

false

The signal recognition particle (SRP) is a multimeric protein, which along with its conjugate receptor (SR), is involved in targeting secretory proteins to the rough endoplasmic reticulum (RER) membrane in eukaryotes, or to the plasma membrane in prokaryotes [ , , ]. SRP recognises the signal sequence of the nascent po...

[ "GO:0008312", "GO:0006614", "GO:0045900", "GO:0048500" ]

[ "7S RNA binding", "SRP-dependent cotranslational protein targeting to membrane", "negative regulation of translational elongation", "signal recognition particle" ]

[ "molecular_function", "biological_process", "biological_process", "cellular_component" ]

4

[ "PIRSF" ]

[ "PIRSF017029" ]

[ "Signal_recog_particle_SRP9" ]

[ 1752 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-CEL-1799339", "R-DDI-1799339", "R-DME-1799339", "R-HSA-1799339", "R-MMU-1799339" ]

[ "REACTOME:R-CEL-1799339", "REACTOME:R-DDI-1799339", "REACTOME:R-DME-1799339", "REACTOME:R-HSA-1799339", "REACTOME:R-MMU-1799339" ]

5

[ "1e8o", "1e8s", "1ry1", "3jaj", "3jan", "4ue5", "4uyj", "4uyk", "5aox", "6frk", "6r6g", "7nfx", "7obr" ]

13

[ "PUB00011467", "PUB00028143", "PUB00035998", "PUB00035999", "PUB00053948", "PUB00063486", "PUB00100261" ]

[ "7730321", "16469117", "17622352", "17507650", "12364595", "12605305", "34020957" ]

[ "Human signal recognition particle (SRP) Alu-associated protein also binds Alu interspersed repeat sequence RNAs. Characterization of human SRP9.", "Human autoantibodies against the 54 kDa protein of the signal recognition particle block function at multiple stages.", "X-ray structures of the signal recognition...

[ 1995, 2006, 2007, 2007, 2002, 2003, 2021 ]

7

[ "IPR039914" ]

[]

1

0

1

[ "Eukaryota" ]

[ 1752 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 3, 1, 1, 1, 4, 4, 1, 2, 3 ]

9

true

Family

Signal recognition particle SRP9

SRP9

7

IPR008834

8,834

Salmonella plasmid virulence SpvD

Sal_SpvD

Family

258

false

This family consists of Salmonella SpvD (also known as VsdE) plasmid virulence proteins. The structure of the protein from Salmonella typhimurium has been solved and shows a papain-like fold, with a predicted catalytic triad of Cys73, His162 and Asp182. The protein has been shown to have deubiquitinating-like activity,...

[]

0

[ "NCBIFAM", "PFAM" ]

[ "NF011786", "PF05563" ]

[ "PRK15250.1", "SpvD" ]

[ 113, 258 ]

2

[]

0

[ "5lq6", "5lq7" ]

2

[ "PUB00083115" ]

[ "27789710" ]

[ "The Salmonella Effector SpvD is a Cysteine Hydrolase with a Serovar-Specific Polymorphism Influencing Catalytic Activity, Suppression of Immune Responses and Bacterial Virulence." ]

[ 2016 ]

1

[]

0

null

[ "Pseudomonadati" ]

[ 258 ]

1

[]

0

true

Family

Salmonella plasmid virulence SpvD

Sal_SpvD

7

IPR008835

8,835

Sclerostin/Sclerostin domain-containing protein 1

Sclerostin/SOSTDC1

Family

1,835

false

This sclerostin family consists of sclerostin and sclerostin domain-containing protein 1. Sclerostin (SOST) is thought to suppress bone formation. Mutations of the SOST gene lead to sclerosteosis, a progressive sclerosing bone dysplasia with an autosomal recessive mode of inheritance. Radiologically, it is characterise...

[ "GO:0005615" ]

[ "extracellular space" ]

[ "cellular_component" ]

1

[ "PFAM", "PANTHER" ]

[ "PF05463", "PTHR14903" ]

[ "Sclerostin", "" ]

[ 1835, 1823 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-201681", "R-HSA-3772470", "R-MMU-3772470", "R-RNO-3772470" ]

[ "REACTOME:R-HSA-201681", "REACTOME:R-HSA-3772470", "REACTOME:R-MMU-3772470", "REACTOME:R-RNO-3772470" ]

4

[ "2k8p", "2kd3", "6l6r" ]

3

[ "PUB00011469", "PUB00059216" ]

[ "11181578", "15020244" ]

[ "Increased bone density in sclerosteosis is due to the deficiency of a novel secreted protein (SOST).", "USAG-1: a bone morphogenetic protein antagonist abundantly expressed in the kidney." ]

[ 2001, 2004 ]

2

[]

0

null

[ "Eumetazoa" ]

[ 1835 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 4, 3, 2, 4 ]

4

true

Family

Sclerostin/Sclerostin domain-containing protein 1

Sclerostin/SOSTDC1

5

IPR008836

8,836

Semenogelin

Family

145

false

This family consists of several mammalian secreted seminal proteins including semenogelin I and II. Freshly ejaculated Homo sapiens semen has the appearance of a loose gel in which the predominant structural protein components are the seminal vesicle secreted semenogelins (Sg) [ ].

[ "GO:0050817", "GO:1901318", "GO:0005576" ]

[ "coagulation", "negative regulation of flagellated sperm motility", "extracellular region" ]

[ "biological_process", "biological_process", "cellular_component" ]

3

[ "PFAM" ]

[ "PF05474" ]

[ "Semenogelin" ]

[ 145 ]

1

[ "REACTOME", "REACTOME" ]

[ "R-HSA-6803157", "R-HSA-977225" ]

[ "REACTOME:R-HSA-6803157", "REACTOME:R-HSA-977225" ]

2

[ "7zro" ]

1

[ "PUB00011470" ]

[ "1584792" ]

[ "Molecular cloning of epididymal and seminal vesicular transcripts encoding a semenogelin-related protein." ]

[ 1992 ]

1

[]

0

null

[ "Euarchontoglires" ]

[ 145 ]

1

[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 9, 1, 4 ]

3

true

Family

Semenogelin

5

IPR008837

8,837

Serendipity locus alpha

Serendipity_A

Family

350

false

The Drosophila serendipity alpha (sry alpha) gene is specifically transcribed at the blastoderm stage, from nuclear cycle 11 to the onset of gastrulation, in all somatic nuclei [ ]. SRY-A is required for the cellularisation of the embryo and is involved in the localisation of the actin filaments just prior to and durin...

[ "GO:0007349", "GO:0005737", "GO:0016020" ]

[ "cellularization", "cytoplasm", "membrane" ]

[ "biological_process", "cellular_component", "cellular_component" ]

3

[ "PFAM" ]

[ "PF05482" ]

[ "Serendipity_A" ]

[ 350 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-DME-418990", "R-DME-5218920", "R-DME-525793", "R-DME-9764561", "R-DME-9766229" ]

[ "REACTOME:R-DME-418990", "REACTOME:R-DME-5218920", "REACTOME:R-DME-525793", "REACTOME:R-DME-9764561", "REACTOME:R-DME-9766229" ]

5

[]

0

[ "PUB00011471", "PUB00011472" ]

[ "2166703", "8287797" ]

[ "The serendipity alpha gene encodes a membrane-associated protein required for the cellularization of the Drosophila embryo.", "Relationship between expression of serendipity alpha and cellularisation of the Drosophila embryo as revealed by interspecific transformation." ]

[ 1990, 1993 ]

2

[]

0

null

[ "Pancrustacea" ]

[ 350 ]

1

[ "Drosophila melanogaster" ]

[ 3 ]

1

true

Family

Serendipity locus alpha

Serendipity_A

7

IPR008838

8,838

Variable surface protein, Brachyspira

Variable_surface_protein_TREHY

Family

318

false

This entry represents a group of variable surface proteins from Brachyspira.

[]

0

[ "PFAM" ]

[ "PF05540" ]

[ "Serpulina_VSP" ]

[ 318 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Brachyspira" ]

[ 318 ]

1

[]

0

true

Family

Variable surface protein, Brachyspira

Variable_surface_protein_TREHY

7

IPR008840

8,840

Siphovirus Gp157

Sipho_Gp157

Family

2,086

false

This family contains both viral and bacterial proteins which are related to the Gp157 protein of the Streptococcus thermophilus SFi bacteriophage. It is thought that bacteria possessing the gene coding for this protein have an increased resistance to the bacteriophage [ ].

[]

0

[ "PFAM" ]

[ "PF05565" ]

[ "Sipho_Gp157" ]

[ 2086 ]

1

[]

0

[]

0

[ "PUB00011474" ]

[ "9792848" ]

[ "A short noncoding viral DNA element showing characteristics of a replication origin confers bacteriophage resistance to Streptococcus thermophilus." ]

[ 1998 ]

1

[]

0

null

[ "Bacteria", "Candidatus Methanofastidiosum methylothiophilum", "Eukaryota", "Viruses", "metagenomes" ]

[ 1744, 3, 5, 302, 32 ]

5

[]

0

true

Family

Siphovirus Gp157

Sipho_Gp157

9

IPR008841

8,841

Siphovirus-type tail component, RIFT-related domain

Siphovirus-type_tail_N

Domain

3,797

false

This entry consists of several phage tail component proteins, including bacteriophage SPP1 distal tail protein Dit (also known as Gp19.1 or Gp19) [ ], as well as some bacterial proteins of unknown function. This entry represents the N-terminal domain.

[]

0

[ "PFAM" ]

[ "PF05709" ]

[ "Sipho_tail" ]

[ 3797 ]

1

[]

0

[ "2x8k", "6v8i", "9j1k" ]

3

[ "PUB00082619" ]

[ "20843802" ]

[ "Crystal structure of bacteriophage SPP1 distal tail protein (gp19.1): a baseplate hub paradigm in gram-positive infecting phages." ]

[ 2010 ]

1

[]

0

null

[ "Bacteria", "Ecdysozoa", "Methanococcus", "Viruses", "metagenomes" ]

[ 3180, 2, 5, 599, 11 ]

5

[]

0

true

Domain

Siphovirus-type tail component, RIFT-related domain

Siphovirus-type_tail_N

5

IPR008843

8,843

Entomopoxvirus spheroidin

Spheroidin

Family

18

false

Entomopoxviruses (EPVs) are large (300-400 nm) oval-shaped viruses replicating in the cytoplasm of their insect host cells. At the end of their replicative cycle EPVs virions are occluded in a highly expressed protein called spheroidin. This protein forms large (5-20 mm long) oval-shaped occlusion bodies (OBs) called s...

[]

0

[ "PFAM" ]

[ "PF05541" ]

[ "Spheroidin" ]

[ 18 ]

1

[]

0

[]

0

[ "PUB00011478" ]

[ "10867199" ]

[ "The spheroidin of an entomopoxvirus isolated from the grasshopper Anacridium aegyptium (AaEPV) shares low homology with spheroidins from lepidopteran or coleopteran EPVs." ]

[ 2000 ]

1

[]

0

null

[ "Dictyosteliales", "Entomopoxvirinae" ]

[ 3, 15 ]

2

[]

0

true

Family

Entomopoxvirus spheroidin

Spheroidin

6

IPR008844

8,844

Spore germination GerAC-like

Spore_GerAC-like

Family

12,984

false

The GerAA, -AB, and -AC proteins of the Bacillus subtilis spore are required for the germination response to L-alanine as the sole germinant. Members of GerAC family are thought to be located in the inner spore membrane. Although the function of this family is unclear, they are likely to encode the components of the ge...

[ "GO:0009847", "GO:0016020" ]

[ "spore germination", "membrane" ]

[ "biological_process", "cellular_component" ]

2

[ "PANTHER", "NCBIFAM" ]

[ "PTHR35789", "TIGR02887" ]

[ "", "spore_ger_x_C" ]

[ 12962, 11978 ]

2

[ "GP" ]

[ "GenProp0610" ]

[ "GP:GenProp0610" ]

1

[ "3n54" ]

1

[ "PUB00011479", "PUB00061591" ]

[ "11418573", "20654628" ]

[ "Localization of GerAA and GerAC germination proteins in the Bacillus subtilis spore.", "Crystal structure of the GerBC component of a Bacillus subtilis spore germinant receptor." ]

[ 2001, 2010 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 12936, 5, 43 ]

3

[ "Arabidopsis thaliana" ]

[ 1 ]

1

true

Family

Spore germination GerAC-like

Spore_GerAC-like

9

IPR008845

8,845

Sporozoite P67 surface antigen

Sporozoite_P67

Domain

123

false

This entry consists of several Theileria P67 surface antigens. A stage specific surface antigen of Theileria parva, p67, is the basis for the development of an anti-sporozoite vaccine for the control of East Coast fever (ECF) in Bos taurus. The antigen has been shown to contain five distinct linear peptide sequences re...

[]

0

[ "PFAM" ]

[ "PF05642" ]

[ "Sporozoite_P67" ]

[ 123 ]

1

[]

0

[ "8ux6" ]

1

[ "PUB00011480", "PUB00163384" ]

[ "10024569", "40384600" ]

[ "Linear peptide specificity of bovine antibody responses to p67 of Theileria parva and sequence diversity of sporozoite-neutralizing epitopes: implications for a vaccine.", "Molecular characterization of a synthetic neutralizing antibody targeting p67 of Theileria parva." ]

[ 1999, 2025 ]

2

[]

0

null

[ "Candidatus Berkiella aquae", "Eukaryota" ]

[ 2, 121 ]

2

[]

0

true

Domain

Sporozoite P67 surface antigen

Sporozoite_P67

2

IPR008846

8,846

Phenol-soluble modulin beta protein

PSMbeta

Family

317

false

This family consists of several different short Staphylococcal proteins known as the phenol-soluble modulin beta proteins, including SLUSH A, B and C proteins as well as haemolysin and gonococcal growth inhibitor [ ]. Some strains of the coagulase-negative Staphylococcus lugdunensis produce a synergistic hemolytic acti...

[]

0

[ "PFAM" ]

[ "PF05480" ]

[ "PSMbeta" ]

[ 317 ]

1

[]

0

[ "5kgz", "7t8u" ]

2

[ "PUB00011481", "PUB00011482", "PUB00083228", "PUB00098628" ]

[ "8975897", "3134553", "18752624", "27525453" ]

[ "Synergistic hemolytic activity of Staphylococcus lugdunensis is mediated by three peptides encoded by a non-agr genetic locus.", "Site of action of a gonococcal growth inhibitor produced by Staphylococcus haemolyticus.", "The amino acid sequences and activities of synergistic hemolysins from Staphylococcus coh...

[ 1997, 1988, 2008, 2016 ]

4

[]

0

null

[ "Bacteria", "Wuchereria bancrofti", "human gut metagenome" ]

[ 315, 1, 1 ]

3

[]

0

true

Family

Phenol-soluble modulin beta protein

PSMbeta

3

IPR008847

8,847

Suppressor of forked

Suf

Domain

9,148

false

This domain consists of several eukaryotic suppressor of forked (Suf) like proteins. The Drosophila melanogaster suppressor of forked [Su(f)] protein shares homology with the Saccharomyces cerevisiae RNA14 protein and the 77kDa subunit of Homo sapiens cleavage stimulation factor, which are proteins involved in mRNA 3' ...

[ "GO:0006396", "GO:0005634" ]

[ "RNA processing", "nucleus" ]

[ "biological_process", "cellular_component" ]

2

[ "PFAM" ]

[ "PF05843" ]

[ "Suf" ]

[ 9148 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-DME-72187", "R-DME-72203", "R-DME-73856", "R-DME-77595", "R-HSA-6790901", "R-HSA-6791226", "R-HSA-72187", "R-HSA-72203", "R-HSA-73856", "R-HSA-77595", "R-MMU-6791226", "R-MMU-72187", "R-MMU-72203", "R-MMU-73856", "R-MMU-77595", "R-SPO-72163", "R-SPO-72203" ]

[ "REACTOME:R-DME-72187", "REACTOME:R-DME-72203", "REACTOME:R-DME-73856", "REACTOME:R-DME-77595", "REACTOME:R-HSA-6790901", "REACTOME:R-HSA-6791226", "REACTOME:R-HSA-72187", "REACTOME:R-HSA-72203", "REACTOME:R-HSA-73856", "REACTOME:R-HSA-77595", "REACTOME:R-MMU-6791226", "REACTOME:R-MMU-72187", ...

17

[ "2ond", "2ooe", "2uy1", "4e6h", "4e85", "4eba", "6uro", "7zy4" ]

8

[ "PUB00011483" ]

[ "9826695" ]

[ "Autoregulation at the level of mRNA 3' end formation of the suppressor of forked gene of Drosophila melanogaster is conserved in Drosophila virilis." ]

[ 1998 ]

1

[]

0

null

[ "Bacteria", "Eukaryota" ]

[ 5, 9143 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 20, 4, 5, 1, 8, 5, 1, 6, 6, 1, 2, 40 ]

12

true

Domain

Suppressor of forked

Suf

6

IPR008849

8,849

Synaphin

Family

5,024

false

This family consists of several eukaryotic synaphin 1 and 2 proteins. Synaphin/complexin is a cytosolic protein that preferentially binds to syntaxin within the SNARE complex. Synaphin promotes SNAREs to form precomplexes that oligomerise into higher order structures. A peptide from the central, syntaxin binding domain...

[ "GO:0019905", "GO:0006836" ]

[ "syntaxin binding", "neurotransmitter transport" ]

[ "molecular_function", "biological_process" ]

2

[ "PFAM", "PANTHER" ]

[ "PF05835", "PTHR16705" ]

[ "Synaphin", "" ]

[ 5023, 4725 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-181429", "R-BTA-181430", "R-BTA-210500", "R-BTA-212676", "R-BTA-264642", "R-BTA-888590", "R-CEL-181429", "R-CEL-181430", "R-CEL-210500", "R-CEL-212676", "R-CEL-264642", "R-CEL-888590", "R-DME-181429", "R-DME-181430", "R-DME-210500", "R-DME-212676", "R-DME-264642", "R-DME-888...

[ "REACTOME:R-BTA-181429", "REACTOME:R-BTA-181430", "REACTOME:R-BTA-210500", "REACTOME:R-BTA-212676", "REACTOME:R-BTA-264642", "REACTOME:R-BTA-888590", "REACTOME:R-CEL-181429", "REACTOME:R-CEL-181430", "REACTOME:R-CEL-210500", "REACTOME:R-CEL-212676", "REACTOME:R-CEL-264642", "REACTOME:R-CEL-888...

36

[ "1kil", "1l4a", "3rk3", "3rl0", "5w5c", "5w5d" ]

6

[ "PUB00011484", "PUB00011485" ]

[ "11239399", "12200427" ]

[ "SNARE complex oligomerization by synaphin/complexin is essential for synaptic vesicle exocytosis.", "Action of complexin on SNARE complex." ]

[ 2001, 2002 ]

2

[]

0

null

[ "Opisthokonta", "bird metagenome" ]

[ 5023, 1 ]

2

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 15, 8, 14, 6, 8 ]

6

true

Family

Synaphin

7

IPR008850

8,850

TEP1, N-terminal

TEP1_N

Repeat

378

false

Telomerase protein component 1 (TP1/TLP1) or TEP1 is a protein component of two ribonucleoprotein (RNP) complexes: vaults and telomerase. Vaults are large RNP particles with a barrel-like structure ( ). The telomerase RNP replenishes incomplete chromosome termini due to DNA replication. Mammalian TEP1 is an RNA-binding...

[]

0

[ "PFAM", "PROFILE" ]

[ "PF05386", "PS51226" ]

[ "TEP1_N", "TEP1_N" ]

[ 378, 377 ]

2

[ "PROSITEDOC" ]

[ "PDOC51226" ]

[ "PROSITEDOC:PDOC51226" ]

1

[]

0

[ "PUB00035328", "PUB00035329" ]

[ "11149928", "15701761" ]

[ "The Telomerase/vault-associated protein TEP1 is required for vault RNA stability and its association with the vault particle.", "The p80 homology region of TEP1 is sufficient for its association with the telomerase and vault RNAs, and the vault particle." ]

[ 2001, 2005 ]

2

[]

0

null

[ "Eutheria" ]

[ 378 ]

1

[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 4, 2, 7 ]

3

true

Repeat

TEP1, N-terminal

TEP1_N

3

IPR008851

8,851

Transcription initiation factor IIF, alpha subunit

TFIIF-alpha

Family

4,847

false

Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) or RNA polymerase II-associating protein 74 (RAP74) is the large subunit of transcription factor IIF (TFIIF), which is essential for accurate initiation and stimulates elongation by RNA polymerase II [ ].

[ "GO:0003677", "GO:0006367", "GO:0032968", "GO:0005634" ]

[ "DNA binding", "transcription initiation at RNA polymerase II promoter", "positive regulation of transcription elongation by RNA polymerase II", "nucleus" ]

[ "molecular_function", "biological_process", "biological_process", "cellular_component" ]

4

[ "PFAM", "PANTHER" ]

[ "PF05793", "PTHR13011" ]

[ "TFIIF_alpha", "" ]

[ 3787, 4576 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-112382", "R-BTA-113418", "R-BTA-674695", "R-BTA-6796648", "R-BTA-6803529", "R-BTA-6807505", "R-BTA-72086", "R-BTA-72163", "R-BTA-72165", "R-BTA-72203", "R-BTA-73776", "R-BTA-73779", "R-BTA-75953", "R-BTA-75955", "R-BTA-76042", "R-BTA-77075", "R-BTA-9018519", "R-DDI-113418", ...

[ "REACTOME:R-BTA-112382", "REACTOME:R-BTA-113418", "REACTOME:R-BTA-674695", "REACTOME:R-BTA-6796648", "REACTOME:R-BTA-6803529", "REACTOME:R-BTA-6807505", "REACTOME:R-BTA-72086", "REACTOME:R-BTA-72163", "REACTOME:R-BTA-72165", "REACTOME:R-BTA-72203", "REACTOME:R-BTA-73776", "REACTOME:R-BTA-73779...

137

[ "1f3u", "1i27", "1j2x", "1nha", "1onv", "2k7l", "4v1n", "4v1o", "5fmf", "5fyw", "5fz5", "5iy6", "5iy7", "5iy8", "5iy9", "5iya", "5iyb", "5iyc", "5iyd", "5oqj", "5oqm", "5sva", "6gyk", "6gyl", "6gym", "6o9l", "7edx", "7eg7", "7eg8", "7eg9", "7ega", "7egb"...

95

[ "PUB00011486" ]

[ "12354769" ]

[ "A key role for the alpha 1 helix of human RAP74 in the initiation and elongation of RNA chains." ]

[ 2002 ]

1

[]

0

null

[ "Eukaryota", "Xenorhabdus", "metagenomes" ]

[ 4842, 2, 3 ]

3

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 7, 1, 9, 1, 7, 3, 1, 10, 4, 1, 1, 15 ]

12

true

Family

Transcription initiation factor IIF, alpha subunit

TFIIF-alpha

2

IPR008853

8,853

TMEM9/TMEM9B

Family

2,841

false

This entry includes human TMEM9/TMEM9B and their homologues. TMEM9 is a transmembrane protein that binds to and facilitates the assembly of lysosomal proton-transporting V-type ATPase (v-ATPase), resulting in enhanced lysosomal acidification and trafficking [ ]. It acts as a Wnt signaling amplifier that hyperactivates ...

[ "GO:0005765" ]

[ "lysosomal membrane" ]

[ "cellular_component" ]

1

[ "PFAM", "PANTHER" ]

[ "PF05434", "PTHR13064" ]

[ "Tmemb_9", "" ]

[ 2831, 2782 ]

2

[]

0

[ "9dnx", "9dny", "9dnz" ]

3

[ "PUB00095096", "PUB00095097", "PUB00095098" ]

[ "32380568", "30374053", "18541524" ]

[ "TMEM9-v-ATPase Activates Wnt/?-Catenin Signaling via APC Lysosomal Degradation for Liver Regeneration and Tumorigenesis.", "TMEM9 promotes intestinal tumorigenesis through vacuolar-ATPase-activated Wnt/?-catenin signalling.", "The lysosomal transmembrane protein 9B regulates the activity of inflammatory signal...

[ 2020, 2018, 2008 ]

3

[]

0

null

[ "Opisthokonta" ]

[ 2841 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 3, 4, 15, 5, 6 ]

6

true

Family

TMEM9/TMEM9B

6

IPR008854

8,854

TPMT family

TPMT

Family

11,001

false

This family consists of thiopurine S-methyltransferase ( ), thiol S-methyltransferase ( ) and thiocyanate methyltransferase ( ). Thiopurine S-methyltransferase is a cytosolic enzyme that catalyses S-methylation of aromatic and heterocyclic sulphydryl compounds, including anticancer and immunosuppressive thiopurines [ ]...

[ "GO:0008757" ]

[ "S-adenosylmethionine-dependent methyltransferase activity" ]

[ "molecular_function" ]

1

[ "PFAM", "PROFILE" ]

[ "PF05724", "PS51585" ]

[ "TPMT", "SAM_MT_TPMT" ]

[ 10506, 10686 ]

2

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "2.1.1.67", "R-BTA-156581", "R-BTA-9748787", "R-CFA-156581", "R-CFA-9748787", "R-DRE-156581", "R-DRE-9748787", "R-HSA-156581", "R-HSA-5578995", "R-HSA-9748787", "R-MMU-156581", "R-MMU-9748787", "R-RNO-156581", "R-RNO-9748787" ]

[ "EC:2.1.1.67", "REACTOME:R-BTA-156581", "REACTOME:R-BTA-9748787", "REACTOME:R-CFA-156581", "REACTOME:R-CFA-9748787", "REACTOME:R-DRE-156581", "REACTOME:R-DRE-9748787", "REACTOME:R-HSA-156581", "REACTOME:R-HSA-5578995", "REACTOME:R-HSA-9748787", "REACTOME:R-MMU-156581", "REACTOME:R-MMU-9748787"...

14

[ "1pjz", "2bzg", "2gb4", "2h11", "3bgd", "3bgi", "3lcc", "6mro", "8ajp" ]

9

[ "PUB00011488", "PUB00043377", "PUB00043378", "PUB00058161" ]

[ "9780226", "16207256", "15570193", "19419967" ]

[ "Functional characterization of the human thiopurine S-methyltransferase (TPMT) gene promoter.", "Thiopurine methyltransferase and 6-thioguanine nucleotide measurement: early experience of use in clinical practice.", "Assessment of thiopurine methyltransferase and metabolite formation during thiopurine therapy:...

[ 1998, 2005, 2004, 2009 ]

4

[]

[ "IPR025835" ]

0

1

0

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences", "uncultured Caudovirales phage" ]

[ 46, 5786, 5052, 116, 1 ]

5

[ "Arabidopsis thaliana", "Danio rerio", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 13, 7, 3, 7, 1, 8, 7, 5 ]

8

true

Family

TPMT family

TPMT

2

IPR008855

8,855

Translocon-associated

TRAP-delta

Family

1,540

false

This family consists of several eukaryotic translocon-associated protein, delta subunit precursors (TRAP-delta or SSR-delta). The exact function of this protein is unknown [ ].

[ "GO:0005783", "GO:0016020" ]

[ "endoplasmic reticulum", "membrane" ]

[ "cellular_component", "cellular_component" ]

2

[ "PFAM", "PANTHER" ]

[ "PF05404", "PTHR12731" ]

[ "TRAP-delta", "" ]

[ 1540, 1478 ]

2

[ "REACTOME" ]

[ "R-HSA-1799339" ]

[ "REACTOME:R-HSA-1799339" ]

1

[ "8b5l", "8b6l", "8bf9", "8btk", "8rjc", "8rjd" ]

6

[ "PUB00011638" ]

[ "7492314" ]

[ "Translocon-associated protein TRAP delta and a novel TRAP-like protein are coordinately expressed with pro-opiomelanocortin in Xenopus intermediate pituitary." ]

[ 1995 ]

1

[]

0

null

[ "Eukaryota", "bird metagenome" ]

[ 1539, 1 ]

2

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 1, 1, 2, 5, 5 ]

6

true

Family

Translocon-associated

TRAP-delta

9

IPR008856

8,856

Translocon-associated protein subunit beta

TRAP_beta

Family

1,167

false

This family consists of several eukaryotic translocon-associated protein beta (TRAPB) or signal sequence receptor beta subunit (SSR-beta) proteins. The normal translocation of nascent polypeptides into the lumen of the endoplasmic reticulum (ER) is thought to be aided in part by a translocon-associated protein (TRAP) c...

[ "GO:0005783", "GO:0016020" ]

[ "endoplasmic reticulum", "membrane" ]

[ "cellular_component", "cellular_component" ]

2

[ "PIRSF" ]

[ "PIRSF016400" ]

[ "TRAP_beta" ]

[ 1167 ]

1

[ "REACTOME" ]

[ "R-HSA-1799339" ]

[ "REACTOME:R-HSA-1799339" ]

1

[ "8b5l", "8b6l", "8bf9", "8btk", "8rjc", "8rjd" ]

6

[ "PUB00011489" ]

[ "11204460" ]

[ "The Translocon-Associated Protein beta (TRAPbeta) in zebrafish embryogenesis. I. Enhanced expression of transcripts in notochord and hatching gland precursors." ]

[ 2000 ]

1

[]

0

null

[ "Eukaryota" ]

[ 1167 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus" ]

[ 4, 2, 2, 1, 3, 3, 3, 2 ]

8

true

Family

Translocon-associated protein subunit beta

TRAP_beta

4

IPR008857

8,857

Thyrotropin-releasing hormone

TRH

Family

888

false

This family consists of several thyrotropin-releasing hormone (TRH) proteins. Thyrotropin-Releasing Hormone (TRH) is a tripeptide (pGlu-His-Pro-NH2) hormone that is primarily produced in the paraventricular nucleus of the hypothalamus and represents the most proximal member of the hypothalamic-pituitary-thyroid (HPT) a...

[ "GO:0008437", "GO:0009755", "GO:0005576" ]

[ "thyrotropin-releasing hormone activity", "hormone-mediated signaling pathway", "extracellular region" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PFAM", "PIRSF" ]

[ "PF05438", "PIRSF001795" ]

[ "TRH", "TRH" ]

[ 888, 835 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-GGA-375276", "R-GGA-416476", "R-HSA-375276", "R-HSA-416476", "R-MMU-375276", "R-MMU-416476", "R-RNO-375276", "R-RNO-416476" ]

[ "REACTOME:R-GGA-375276", "REACTOME:R-GGA-416476", "REACTOME:R-HSA-375276", "REACTOME:R-HSA-416476", "REACTOME:R-MMU-375276", "REACTOME:R-MMU-416476", "REACTOME:R-RNO-375276", "REACTOME:R-RNO-416476" ]

8

[]

0

[ "PUB00085125" ]

[ "19179434" ]

[ "Minireview: Thyrotropin-releasing hormone and the thyroid hormone feedback mechanism." ]

[ 2009 ]

1

[]

0

null

[ "Bilateria" ]

[ 888 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 2, 1, 2 ]

4

true

Family

Thyrotropin-releasing hormone

TRH

7

IPR008858

8,858

TROVE domain

TROVE_dom

Domain

6,062

false

The TROVE (Telomerase, Ro and Vault) domain is a module of ~300-500 residues that is found in TEP1 and Ro60 the protein components of three ribonucleoprotein particles. It is also found in bacterial ribonucleoproteins suggesting an ancient origin of these ribonucleoproteins. It can be found associated with other domain...

[ "GO:0003723" ]

[ "RNA binding" ]

[ "molecular_function" ]

1

[ "PFAM", "PROFILE" ]

[ "PF05731", "PS50988" ]

[ "TROVE", "TROVE" ]

[ 5251, 5988 ]

2

[ "PROSITEDOC" ]

[ "PDOC50988" ]

[ "PROSITEDOC:PDOC50988" ]

1

[ "1yvp", "1yvr", "2i91", "2nvo", "9kop" ]

5

[ "PUB00014100", "PUB00038651", "PUB00048398" ]

[ "14563212", "15907467", "17392270" ]

[ "The TROVE module: a common element in Telomerase, Ro and Vault ribonucleoproteins.", "Structural insights into RNA quality control: the Ro autoantigen binds misfolded RNAs via its central cavity.", "Crystal structure of Rsr, an ortholog of the antigenic Ro protein, links conformational flexibility to RNA bindi...

[ 2003, 2005, 2007 ]

3

[]

0

null

[ "Bacteria", "Eukaryota", "Methanobacteriota", "Viruses", "metagenomes" ]

[ 2831, 3013, 46, 131, 41 ]

5

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 3, 3, 7, 6, 11 ]

6

true

Domain

TROVE domain

TROVE_dom

4

IPR008859

8,859

Thrombospondin, C-terminal

Thrombospondin_C

Domain

9,831

false

This entry represents the C-terminal domain of Thrombospondin homologues. The globular C-terminal domain is a β sandwich of two curved antiparallel β-sheets [ ]. The fold is an elaboration of the jelly role topology, with strand B3-B7, B11 and B14-B15 forming the eight-stranded jelly roll motif. The function of the C-t...

[ "GO:0005509", "GO:0007155", "GO:0005576" ]

[ "calcium ion binding", "cell adhesion", "extracellular region" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PFAM", "PROFILE" ]

[ "PF05735", "PS51236" ]

[ "TSP_C", "TSP_CTER" ]

[ 9792, 9815 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-216083", "R-BTA-3000178", "R-HSA-114608", "R-HSA-186797", "R-HSA-216083", "R-HSA-3000170", "R-HSA-3000178", "R-HSA-5083635", "R-HSA-5173214", "R-HSA-8936459", "R-MMU-114608", "R-MMU-186797", "R-MMU-216083", "R-MMU-3000178", "R-MMU-5173214", "R-RNO-186797", "R-RNO-216083", "R...

[ "REACTOME:R-BTA-216083", "REACTOME:R-BTA-3000178", "REACTOME:R-HSA-114608", "REACTOME:R-HSA-186797", "REACTOME:R-HSA-216083", "REACTOME:R-HSA-3000170", "REACTOME:R-HSA-3000178", "REACTOME:R-HSA-5083635", "REACTOME:R-HSA-5173214", "REACTOME:R-HSA-8936459", "REACTOME:R-MMU-114608", "REACTOME:R-M...

18

[ "1ux6", "1yo8", "2rhp", "3fby" ]

4

[ "PUB00037903", "PUB00043707" ]

[ "15014436", "11687483" ]

[ "Structure of a thrombospondin C-terminal fragment reveals a novel calcium core in the type 3 repeats.", "Thrombospondins: multifunctional regulators of cell interactions." ]

[ 2004, 2001 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "marine sediment metagenome" ]

[ 153, 9677, 1 ]

3

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 18, 4, 23, 18, 13 ]

5

true

Domain

Thrombospondin, C-terminal

Thrombospondin_C

7

IPR008860

8,860

Taeniidae antigen

Taeniidae_ag

Family

353

false

This family consists of several antigen proteins found in flatworms.

[]

0

[ "PFAM" ]

[ "PF05596" ]

[ "Taeniidae_ag" ]

[ 353 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Eucestoda" ]

[ 353 ]

1

[]

0

true

Family

Taeniidae antigen

Taeniidae_ag

4

IPR008861

8,861

Phage Tail Protein X-like

GpX-like

Family

4,905

false

This entry includes GpX protein from Bacteriophage P2. GpX is a phage tail protein [ ]. Sequence analysis suggests that they are related to which suggests a general peptidoglycan binding function. This entry also includes uncharacterised bacterial proteins.

[]

0

[ "PFAM" ]

[ "PF05489" ]

[ "Phage_tail_X" ]

[ 4905 ]

1

[ "GP" ]

[ "GenProp0208" ]

[ "GP:GenProp0208" ]

1

[ "2ltf", "6u5b", "6u5k" ]

3

[ "PUB00076907" ]

[ "24097944" ]

[ "Structural and functional studies of gpX of Escherichia coli phage P2 reveal a widespread role for LysM domains in the baseplates of contractile-tailed phages." ]

[ 2013 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "Viruses", "metagenomes" ]

[ 4677, 12, 203, 13 ]

4

[]

0

true

Family

Phage Tail Protein X-like

GpX-like

8

IPR008862

8,862

T-complex 11

Tcp11

Family

8,592

false

This family consists of several eukaryotic T-complex protein 11 (Tcp11) related sequences. Tcp11 is only expressed in fertile adult mammalian testes and is thought to be important in sperm function and fertility. The family also contains the Saccharomyces cerevisiae Sok1 protein which is known to suppress cyclic AMP-de...

[]

0

[ "PFAM", "PANTHER" ]

[ "PF05794", "PTHR12832" ]

[ "Tcp11", "" ]

[ 8412, 8320 ]

2

[]

0

[]

0

[ "PUB00011492" ]

[ "8065298" ]

[ "Suppression of a yeast cyclic AMP-dependent protein kinase defect by overexpression of SOK1, a yeast gene exhibiting sequence similarity to a developmentally regulated mouse gene." ]

[ 1994 ]

1

[]

0

null

[ "Eukaryota", "Imitervirales", "Pseudomonadota", "metagenomes" ]

[ 8565, 4, 10, 13 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 10, 1, 16, 1, 25, 11, 2, 13, 13, 1, 15 ]

11

true

Family

T-complex 11

Tcp11

6

IPR008863

8,863

Toxic anion resistance

Toxic_anion-R_TelA

Family

7,893

false

This family consists of several prokaryotic TelA like proteins. TelA and KlA are associated with tellurite resistance [ ] and plasmid fertility inhibition [ ].

[]

0

[ "PFAM", "PIRSF", "PANTHER" ]

[ "PF05816", "PIRSF026508", "PTHR38432" ]

[ "TelA", "TelA", "" ]

[ 7892, 5153, 7423 ]

3

[]

0

[]

0

[ "PUB00011493", "PUB00011494" ]

[ "9406390", "7665479" ]

[ "Identification and molecular genetic analysis of multiple loci contributing to high-level tellurite resistance in Rhodobacter sphaeroides 2.4.1.", "Phage inhibition, colicin resistance, and tellurite resistance are encoded by a single cluster of genes on the IncHI2 plasmid R478." ]

[ 1997, 1995 ]

2

[]

0

null

[ "Bacteria", "Birmingham IncP-alpha plasmid", "Eukaryota", "Methanobacteriota", "Viruses", "metagenomes" ]

[ 7733, 2, 7, 24, 82, 45 ]

6

[]

0

true

Family

Toxic anion resistance

Toxic_anion-R_TelA

4

IPR008864

8,864

Nucleocapsid, Tenuivirus

Nucleocapsid_Tenuivirus

Family

160

false

This family consists of several Tenuivirus nucleocapsid proteins [ ].

[ "GO:0019013" ]

[ "viral nucleocapsid" ]

[ "cellular_component" ]

1

[ "PIRSF" ]

[ "PIRSF004108" ]

[ "Tenuivirus_N" ]

[ 160 ]

1

[]

0

[]

0

[ "PUB00011495" ]

[ "2024478" ]

[ "Nucleotide sequence and RNA hybridization analyses reveal an ambisense coding strategy for maize stripe virus RNA3." ]

[ 1991 ]

1

[]

0

null

[ "Tenuivirus" ]

[ 160 ]

1

[]

0

true

Family

Nucleocapsid, Tenuivirus

Nucleocapsid_Tenuivirus

9

IPR008865

8,865

DNA replication terminus site-binding protein

DNA_replication_term_site-bd

Family

2,524

false

This entry contains several bacterial DNA replication terminus site-binding proteins (also known as Tus or Ter-binding proteins). They are required for the termination of DNA replication and function by binding to DNA replication terminator sequences, thus preventing the passage of replication forks [ ]. The terminatio...

[ "GO:0003677", "GO:0006274", "GO:0005737" ]

[ "DNA binding", "DNA replication termination", "cytoplasm" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "HAMAP", "PFAM", "NCBIFAM" ]

[ "MF_00483", "PF05472", "TIGR02648" ]

[ "Rep_term_Tus", "Ter", "rep_term_tus" ]

[ 1218, 2524, 1570 ]

3

[]

0

[ "1ecr", "1sut", "2ewj", "2i05", "2i06", "4xr0", "4xr1", "4xr2", "4xr3" ]

9

[ "PUB00011496" ]

[ "2687269" ]

[ "Purification of a DNA replication terminus (ter) site-binding protein in Escherichia coli and identification of the structural gene." ]

[ 1989 ]

1

[]

0

null

[ "Bacteria", "IncT plasmid R394", "Opisthokonta", "metagenomes" ]

[ 2514, 1, 2, 7 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

DNA replication terminus site-binding protein

DNA_replication_term_site-bd

3

IPR008866

8,866

Bacteriophage lambda, GpA-like

Phage_lambda_GpA-like

Family

3,759

false

This entry consists of several phage terminase large subunit proteins, including GpA (also known as TerL) from Bacteriophage lambda and from Enterobacteria phage P21, as well as related sequences from several bacterial species. The DNA packaging enzyme of Bacteriophage lambda, terminase, is a heteromultimer composed of...

[ "GO:0004519", "GO:0005524", "GO:0016887" ]

[ "endonuclease activity", "ATP binding", "ATP hydrolysis activity" ]

[ "molecular_function", "molecular_function", "molecular_function" ]

3

[ "HAMAP" ]

[ "MF_04144" ]

[ "TERL_LAMBDA" ]

[ 3759 ]

1

[ "GP" ]

[ "GenProp0208" ]

[ "GP:GenProp0208" ]

1

[]

0

[ "PUB00011497", "PUB00095690", "PUB00095691" ]

[ "11866517", "22191393", "28445747" ]

[ "The large subunit of bacteriophage lambda's terminase plays a role in DNA translocation and packaging termination.", "Energy-independent helicase activity of a viral genome packaging motor.", "Physical and Functional Characterization of a Viral Genome Maturation Complex." ]

[ 2002, 2012, 2017 ]

3

[]

0

null

[ "Bacteria", "Eukaryota", "Viruses", "metagenomes" ]

[ 3491, 12, 242, 14 ]

4

[]

0

true

Family

Bacteriophage lambda, GpA-like

Phage_lambda_GpA-like

8

IPR008868

8,868

Bacterial TniB

TniB

Family

4,507

false

This family consists of several bacterial TniB NTP-binding proteins. TniB is a probable ATP-binding protein [ ] which is involved in Tn5053 mercury resistance transposition [ ].

[]

0

[ "PFAM" ]

[ "PF05621" ]

[ "TniB" ]

[ 4507 ]

1

[]

0

[ "7m99", "7m9a", "7m9b", "7m9c", "7n6i", "7plh", "7rzy", "7svu", "7svv", "7ufi", "7ufm", "8bd4", "8bd5", "8bd6", "8ea3", "8ea4", "8rdu", "8rku" ]

18

[ "PUB00011499", "PUB00011500" ]

[ "8195081", "8594337" ]

[ "Transposon Tn5090 of plasmid R751, which carries an integron, is related to Tn7, Mu, and the retroelements.", "Four genes, two ends, and a res region are involved in transposition of Tn5053: a paradigm for a novel family of transposons carrying either a mer operon or an integron." ]

[ 1994, 1995 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "Promethearchaeaceae", "metagenomes", "plasmids" ]

[ 4455, 20, 2, 26, 4 ]

5

[]

0

true

Family

Bacterial TniB

TniB

8

IPR008869

8,869

Toluene tolerance Ttg2/phospholipid-binding protein MlaC

MlaC/ttg2D

Family

10,056

false

This family includes toluene tolerance protein Ttg2 and intermembrane phospholipid transport system binding protein MlaC. Proteins in this family show similarity to ABC transporters [ , ]. Toluene tolerance is mediated by increased cell membrane rigidity resulting from changes in fatty acid and phospholipid composition...

[]

0

[ "PFAM", "PIRSF", "PANTHER" ]

[ "PF05494", "PIRSF004649", "PTHR36573" ]

[ "MlaC", "MlaC", "" ]

[ 10050, 6832, 9640 ]

3

[]

0

[ "2qgu", "4fcz", "5uwa", "5uwb", "6gki", "6hsy", "7vr6", "8dte", "8i8x", "8oj4", "8ojg" ]

11

[ "PUB00011501", "PUB00011502", "PUB00059298" ]

[ "9020089", "9658016", "19383799" ]

[ "Mechanisms for solvent tolerance in bacteria.", "Isolation and characterization of toluene-sensitive mutants from the toluene-resistant bacterium Pseudomonas putida GM73.", "An ABC transport system that maintains lipid asymmetry in the gram-negative outer membrane." ]

[ 1997, 1998, 2009 ]

3

[]

[ "IPR017842" ]

0

1

0

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 9821, 26, 209 ]

3

[ "Arabidopsis thaliana", "Escherichia coli (strain K12)" ]

[ 1, 1 ]

2

true

Family

Toluene tolerance Ttg2/phospholipid-binding protein MlaC

MlaC/ttg2D

1

IPR008871

8,871

Totivirus coat

Totivirus_coat

Family

225

false

This family of proteins contain the coat proteins of the Totiviruses.

[]

0

[ "PFAM" ]

[ "PF05518" ]

[ "Totivirus_coat" ]

[ 225 ]

1

[]

0

[ "6y83", "7ns2", "7z90" ]

3

[]

0

[]

0

null

[ "Eukaryota", "Riboviria", "viral metagenome" ]

[ 13, 209, 3 ]

3

[]

0

true

Family

Totivirus coat

Totivirus_coat

5

IPR008872

8,872

Insecticidal crystal toxin

Toxin_P42

Domain

141

false

This entry represents a domain found in insecticidal crystal toxins. Strains of Bacillus that have this insecticidal activity use a binary toxin comprised of two proteins, P51 and P42 (this entry) [ ]. This domain is also found in Binary larvicide subunit BinA, a component of a binary toxin active against Culex and som...

[ "GO:0090729" ]

[ "toxin activity" ]

[ "molecular_function" ]

1

[ "PFAM" ]

[ "PF05431" ]

[ "Toxin_10" ]

[ 141 ]

1

[]

0

[ "4jp0", "5foy", "5foz", "5g37", "7y78", "7y79", "8bad" ]

7

[ "PUB00011503", "PUB00097074", "PUB00151926" ]

[ "9500937", "25514092", "8419297" ]

[ "Variants of the Bacillus sphaericus binary toxins: implications for differential toxicity of strains.", "Bacillus thuringiensis toxins: an overview of their biocidal activity.", "Genetic determinants of host ranges of Bacillus sphaericus mosquito larvicidal toxins." ]

[ 1998, 2014, 1993 ]

3

[]

0

null

[ "Bacteria", "Physarum polycephalum" ]

[ 140, 1 ]

2

[]

0

true

Domain

Insecticidal crystal toxin

Toxin_P42

5

IPR008873

8,873

TraA

Family

921

false

Conjugative transfer of a bacteriocin plasmid, pPD1, of Enterococcus faecalis is induced in response to a peptide sex pheromone, cPD1, secreted from plasmid-free recipient cells. cPD1 is taken up by a pPD1 donor cell and binds to an intracellular receptor, TraA. Once a recipient cell acquires pPD1, it starts to produce...

[ "GO:0005576" ]

[ "extracellular region" ]

[ "cellular_component" ]

1

[ "PFAM", "NCBIFAM" ]

[ "PF05513", "TIGR02758" ]

[ "TraA", "TraA_TIGR" ]

[ 853, 696 ]

2

[ "GP" ]

[ "GenProp0485" ]

[ "GP:GenProp0485" ]

1

[ "5leg", "5ler", "5lfb", "6nm5", "7jsv", "9moq", "9mzt" ]

7

[ "PUB00011504" ]

[ "12399504" ]

[ "Functional analysis of TraA, the sex pheromone receptor encoded by pPD1, in a promoter region essential for the mating response in Enterococcus faecalis." ]

[ 2002 ]

1

[]

0

null

[ "Opisthokonta", "Plasmid R124", "Pseudomonadota", "human gut metagenome" ]

[ 2, 1, 916, 2 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

TraA

8

IPR008874

8,874

Enterobacterial TraT complement resistance

TraT_complement-R

Family

1,458

false

The traT gene is one of the F factor transfer genes and encodes an outer membrane protein which is involved in interactions between Escherichia coli and its surroundings [ ]. The protein plays a role in preventing unproductive conjugation between bacteria carrying like plasmids.

[ "GO:0019867" ]

[ "outer membrane" ]

[ "cellular_component" ]

1

[ "PFAM", "PIRSF" ]

[ "PF05818", "PIRSF002859" ]

[ "TraT", "Lipo_traT" ]

[ 1458, 1201 ]

2

[]

0

[ "9e2v", "9fs5", "9fsm" ]

3

[ "PUB00011625" ]

[ "9933744" ]

[ "Expression of foreign antigens on the surface of Escherichia coli by fusion to the outer membrane protein traT." ]

[ 1999 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 1438, 3, 17 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Enterobacterial TraT complement resistance

TraT_complement-R

1

IPR008875

8,875

TraX

Family

5,677

false

This family consists of several bacterial TraX proteins. TraX is responsible for the N-terminal acetylation of F-pilin subunits [ ].

[]

0

[ "PFAM" ]

[ "PF05857" ]

[ "TraX" ]

[ 5677 ]

1

[]

0

[]

0

[ "PUB00011624" ]

[ "8444800" ]

[ "The Escherichia coli K-12 F plasmid gene traX is required for acetylation of F pilin." ]

[ 1993 ]

1

[]

[ "IPR014125" ]

0

1

0

[ "Bacteria", "Inoviridae", "MCG-1", "Opisthokonta", "metagenomes", "plasmids" ]

[ 5620, 5, 2, 15, 28, 7 ]

6

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

TraX

8

IPR008876

8,876

Relaxosome protein TraY

TraY

Family

1,215

false

TraY is part of the relaxosome, a complex of DNA-processing proteins required for the initiation of conjugative DNA transfer. It facilitates a site- and strand-specific cut in the origin of transfer by TraI, at the nic site [ ].

[ "GO:0003677" ]

[ "DNA binding" ]

[ "molecular_function" ]

1

[ "PFAM" ]

[ "PF05509" ]

[ "TraY" ]

[ 1215 ]

1

[]

0

[ "9f0x", "9f0y", "9f0z", "9f10", "9f11", "9f12" ]

6

[ "PUB00077040" ]

[ "17238924" ]

[ "The F plasmid-encoded TraM protein stimulates relaxosome-mediated cleavage at oriT through an interaction with TraI." ]

[ 2007 ]

1

[]

0

null

[ "Bacteria", "Opisthokonta", "metagenomes" ]

[ 1195, 3, 17 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Relaxosome protein TraY

TraY

9

IPR008878

8,878

Transposase IS66, Orf2

Transposase_IS66_Orf2

Family

15,056

false

This entry represents a group of bacterial proteins found in insertion sequences related to IS66. The function of these proteins is uncertain, but they are probably essential for transposition. The IS66 family insertion sequence element encodes a DDE transposase TnpC, and two accessory proteins, TnpA and TnpB. It has b...

[]

0

[ "NCBIFAM", "PFAM", "PANTHER" ]

[ "NF033819", "PF05717", "PTHR36455" ]

[ "IS66_TnpB", "TnpB_IS66", "" ]

[ 13642, 15051, 13879 ]

3

[]

0

[]

0

[ "PUB00011506" ]

[ "11418571" ]

[ "Structural and functional characterization of IS679 and IS66-family elements." ]

[ 2001 ]

1

[]

0

null

[ "Bacteria", "Caudoviricetes", "Eukaryota", "Methanosarcina mazei", "metagenomes" ]

[ 14827, 9, 24, 2, 194 ]

5

[]

0

true

Family

Transposase IS66, Orf2

Transposase_IS66_Orf2

9

IPR008879

8,879

Coat protein, trichovirus/vitivirus

Coat_protein_tricho/vitivirus

Family

2,502

false

This family consists of several coat proteins which are specific to the ssRNA positive-strand, no DNA stage viruses such as the Trichoviruses and Vitiviruses [ ].

[ "GO:0019028" ]

[ "viral capsid" ]

[ "cellular_component" ]

1

[ "PFAM", "PIRSF" ]

[ "PF05892", "PIRSF004075" ]

[ "Tricho_coat", "Coat_protein_tricho/vitivirus" ]

[ 2502, 1344 ]

2

[]

0

[]

0

[ "PUB00020488" ]

[ "7944948" ]

[ "Nucleotide sequence of the 3' terminal region of the RNA of two filamentous grapevine viruses." ]

[ 1994 ]

1

[]

0

null

[ "Pentapetalae", "Tymovirales" ]

[ 3, 2499 ]

2

[]

0

true

Family

Coat protein, trichovirus/vitivirus

Coat_protein_tricho/vitivirus

6

IPR008880

8,880

Trigger factor, C-terminal

Trigger_fac_C

Domain

25,562

false

In the Escherichia coli cytosol, a fraction of the newly synthesised proteins requires the activity of molecular chaperones for folding to the native state. The major chaperones implicated in this folding process are the ribosome-associated Trigger Factor (TF), and the DnaK and GroEL chaperones with their respective co...

[ "GO:0006457", "GO:0015031" ]

[ "protein folding", "protein transport" ]

[ "biological_process", "biological_process" ]

2

[ "PFAM" ]

[ "PF05698" ]

[ "Trigger_C" ]

[ 25562 ]

1

[ "EC" ]

[ "5.2.1.8" ]

[ "EC:5.2.1.8" ]

1

[ "1t11", "1w26", "2mlx", "2mly", "2mlz", "2nsa", "2vrh", "3gty", "3gu0", "5owi", "5owj", "6d6s", "6j0a", "6j45", "7d80", "7zgi", "8p7x", "8p7y", "8p8b", "8p8v", "8p8w", "8zfi", "9wnr" ]

23

[ "PUB00011507", "PUB00099906", "PUB00099907" ]

[ "12603737", "29222465", "32358557" ]

[ "Trigger Factor and DnaK possess overlapping substrate pools and binding specificities.", "The dynamic dimer structure of the chaperone Trigger Factor.", "Inter-domain dynamics in the chaperone SurA and multi-site binding to its outer membrane protein clients." ]

[ 2003, 2017, 2020 ]

3

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences", "uncultured Caudovirales phage" ]

[ 24153, 853, 555, 1 ]

4

[ "Arabidopsis thaliana", "Escherichia coli (strain K12)", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 3, 1, 2, 6 ]

4

true

Domain

Trigger factor, C-terminal

Trigger_fac_C

7

IPR008881

8,881

Trigger factor, ribosome-binding, bacterial

Trigger_fac_ribosome-bd_bac

Domain

27,750

false

In the Escherichia coli cytosol, a fraction of the newly synthesised proteins requires the activity of molecular chaperones for folding to the native state. The major chaperones implicated in this folding process are the ribosome-associated Trigger Factor (TF), and the DnaK and GroEL chaperones with their respective co...

[ "GO:0006457", "GO:0015031" ]

[ "protein folding", "protein transport" ]

[ "biological_process", "biological_process" ]

2

[ "PFAM" ]

[ "PF05697" ]

[ "Trigger_N" ]

[ 27750 ]

1

[ "EC" ]

[ "5.2.1.8" ]

[ "EC:5.2.1.8" ]

1

[ "1oms", "1p9y", "1t11", "1w26", "1w2b", "2aar", "2d3o", "2mlx", "2mly", "2mlz", "2nsb", "2nsc", "2vrh", "3gty", "3gu0", "4urd", "5owi", "5owj", "6d6s", "6j0a", "6j45", "7d6z", "7d80", "7zgi", "8p7x", "8p7y", "8p8b", "8p8v", "8p8w", "8zfi", "9wnr" ]

31

[ "PUB00011507" ]

[ "12603737" ]

[ "Trigger Factor and DnaK possess overlapping substrate pools and binding specificities." ]

[ 2003 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences", "uncultured Caudovirales phage" ]

[ 25465, 1741, 543, 1 ]

4

[ "Arabidopsis thaliana", "Escherichia coli (strain K12)", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 7, 1, 7, 19 ]

4

true

Domain

Trigger factor, ribosome-binding, bacterial

Trigger_fac_ribosome-bd_bac

3

IPR008882

8,882

Procyclic acidic repetitive

Trypano_PARP

Family

33

false

This family consists of several Trypanosoma brucei procyclic acidic repetitive protein (PARP) like sequences. The procyclic acidic repetitive protein (parp) genes of T. brucei encode a small family of abundant surface proteins whose expression is restricted to the procyclic form of the parasite. They are found at two u...

[ "GO:0016020" ]

[ "membrane" ]

[ "cellular_component" ]

1

[ "PFAM" ]

[ "PF05887" ]

[ "Trypan_PARP" ]

[ 33 ]

1

[]

0

[]

0

[ "PUB00011508" ]

[ "2342468" ]

[ "Transcription of the procyclic acidic repetitive protein genes of Trypanosoma brucei." ]

[ 1990 ]

1

[]

0

null

[ "Eukaryota" ]

[ 33 ]

1

[]

0

true

Family

Procyclic acidic repetitive

Trypano_PARP

9

IPR008883

8,883

Ubiquitin E2 variant, N-terminal

UEV_N

Domain

7,122

false

The N-terminal ubiquitin E2 variant (UEV) domain is ~145 amino acid residues in length and shows significant sequence similarity to E2 ubiquitin ligases but is unable to catalyze ubiquitin transfer as it lacks the active site cysteine that forms the transient thioester bond with the C terminus of ubiquitin (Ub). Nevert...

[ "GO:0015031", "GO:0036211" ]

[ "protein transport", "protein modification process" ]

[ "biological_process", "biological_process" ]

2

[ "PFAM", "PROFILE" ]

[ "PF05743", "PS51322" ]

[ "UEV", "UEV" ]

[ 7013, 6992 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-DDI-917729", "R-HSA-162588", "R-HSA-174490", "R-HSA-917729", "R-HSA-9610379", "R-HSA-9615710", "R-MMU-917729", "R-RNO-917729", "R-SCE-917729" ]

[ "REACTOME:R-DDI-917729", "REACTOME:R-HSA-162588", "REACTOME:R-HSA-174490", "REACTOME:R-HSA-917729", "REACTOME:R-HSA-9610379", "REACTOME:R-HSA-9615710", "REACTOME:R-MMU-917729", "REACTOME:R-RNO-917729", "REACTOME:R-SCE-917729" ]

9

[ "1kpp", "1kpq", "1m4p", "1m4q", "1s1q", "1uzx", "2f0r", "3obq", "3obs", "3obu", "3obx", "3p9g", "3p9h", "3r3q", "3r42", "4eje", "4yc1", "4zny", "5vkg", "6ud0", "7nlc", "7zlx" ]

22

[ "PUB00003446", "PUB00003903", "PUB00011509", "PUB00026796", "PUB00031958" ]

[ "9253709", "9241264", "12482969", "12006492", "15044434" ]

[ "The breast cancer gene product TSG101: a regulator of ubiquitination?", "TSG101 may be the prototype of a class of dominant negative ubiquitin regulators.", "Tsg101 is essential for cell growth, proliferation, and cell survival of embryonic and adult tissues.", "Structure and functional interactions of the T...

[ 1997, 1997, 2003, 2002, 2004 ]

5

[]

0

null

[ "Catovirus CTV1", "Eukaryota" ]

[ 1, 7121 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 9, 1, 10, 2, 5, 10, 1, 3, 9, 1, 8 ]

11

true

Domain

Ubiquitin E2 variant, N-terminal

UEV_N

1

IPR008884

8,884

Macrocin-O-methyltransferase

TylF_MeTrfase

Family

4,840

false

This family consists of bacterial macrocin O-methyltransferase (TylF) proteins. TylF is responsible for the methylation of macrocin to produce tylosin. Tylosin is a macrolide antibiotic used in veterinary medicine to treat infections caused by Gram-positive bacteria and as an animal growth promoter in the Sus scrofa (P...

[]

0

[ "PFAM", "PANTHER" ]

[ "PF05711", "PTHR40036" ]

[ "TylF", "" ]

[ 3800, 4684 ]

2

[]

0

[ "2wk1", "3tos", "4cdz", "4ce0", "4gf5", "4x7u", "4x7v", "4x7w", "4x7x", "4x7y", "4x7z", "4x81", "4xvy", "4xvz", "5hoq", "5i10" ]

16

[ "PUB00011510" ]

[ "10220165" ]

[ "The tylosin biosynthetic cluster from Streptomyces fradiae: genetic organization of the left region." ]

[ 1999 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 32, 3945, 621, 73, 169 ]

5

[]

0

true

Family

Macrocin-O-methyltransferase

TylF_MeTrfase

7

IPR008886

8,886

Uncharacterised protein family UPF0227/Esterase YqiA

UPF0227/Esterase_YqiA

Family

8,379

false

Despite being classed as uncharacterised proteins, the members of this family are almost certainly enzymes in that contain a domain distantly related to . One of the members of this family YqiA has been shown to be a esterase [ ]. Other members, which include the Escherichia coli (strain K12) YcfP protein, are uncharac...

[]

0

[ "PFAM", "PANTHER" ]

[ "PF05728", "PTHR35602" ]

[ "UPF0227", "" ]

[ 8379, 7192 ]

2

[]

0

[ "4fle", "9bi7" ]

2

[ "PUB00053777" ]

[ "15808744" ]

[ "Enzyme genomics: Application of general enzymatic screens to discover new enzymes." ]

[ 2005 ]

1

[]

[ "IPR022987" ]

0

1

0

[ "Bacteria", "Eukaryota", "Methanobacteriota", "Viruses", "unclassified sequences" ]

[ 8219, 81, 4, 5, 70 ]

5

[ "Escherichia coli (strain K12)" ]

[ 2 ]

1

true

Family

Uncharacterised protein family UPF0227/Esterase YqiA

UPF0227/Esterase_YqiA

9

IPR008887

8,887

Uncharacterised protein family UPF0228

UPF0228

Family

179

false

This small family of proteins is currently restricted to Methanosarcina species. Members of this family are about 200 residues in length, except for that has two copies of this region. Although the function of this region is unknown the pattern of conservation suggests that this may be an enzyme, including multiple con...

[]

0

[ "PFAM" ]

[ "PF05727" ]

[ "UPF0228" ]

[ 179 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Methanosarcinaceae", "Physocladia obscura", "bioreactor metagenome" ]

[ 175, 1, 3 ]

3

[]

0

true

Family

Uncharacterised protein family UPF0228

UPF0228

7

IPR008888

8,888

Ustilago B locus mating-type

Ustilago_mating

Domain

74

false

This domain consists of several Ustilago mating-type proteins. The b locus of the phytopathogenic fungus Ustilago maydis encodes a multiallelic recognition function that controls the ability of the fungus to form a dikaryon and complete the sexual stage of the life cycle. The b locus has at least 25 alleles and any com...

[ "GO:0003677", "GO:0005634" ]

[ "DNA binding", "nucleus" ]

[ "molecular_function", "cellular_component" ]

2

[ "PFAM" ]

[ "PF05722" ]

[ "Ustilago_mating" ]

[ 74 ]

1

[]

0

[]

0

[ "PUB00011512" ]

[ "2227416" ]

[ "The b mating-type locus of Ustilago maydis contains variable and constant regions." ]

[ 1990 ]

1

[]

0

null

[ "Ustilaginomycotina" ]

[ 74 ]

1

[]

0

true

Domain

Ustilago B locus mating-type

Ustilago_mating

7

IPR008889

8,889

VQ

Domain

15,379

false

This short motif is found in a variety of plant proteins. These proteins vary greatly in length and are mostly composed of low complexity regions. They all conserve a short motif FXhVQChTG, where X is any amino acid and h is a hydrophobic amino acid. The function of this motif is uncertain, however one protein in this ...

[]

0

[ "PFAM" ]

[ "PF05678" ]

[ "VQ" ]

[ 15379 ]

1

[]

0

[ "8k31" ]

1

[]

0

[]

0

null

[ "Eukaryota", "Humibacillus xanthopallidus" ]

[ 15378, 1 ]

2

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 114, 107, 151 ]

3

true

Domain

VQ

4

IPR008890

8,890

Vibrio cholerae RfbT

V_cholerae_RfbT

Family

36

false

This family consists of several RfbT proteins from Vibrio cholerae. It has been found that genetic alteration of the rfbT gene is responsible for serotype conversion of V. cholerae O1 [ ] and determines the difference between the Ogawa and Inaba serotypes, in that the presence of rfbT is sufficient for Inaba-to-Ogawa s...

[]

0

[ "PFAM" ]

[ "PF05575" ]

[ "V_cholerae_RfbT" ]

[ 36 ]

1

[]

0

[]

0

[ "PUB00011513", "PUB00011514" ]

[ "7688846", "11035750" ]

[ "Mutations in the rfbT gene are responsible for the Ogawa to inaba serotype conversion in Vibrio cholerae O1.", "Construction of a Vibrio cholerae vaccine candidate using transposon delivery and FLP recombinase-mediated excision." ]

[ 1993, 2000 ]

2

[]

[ "IPR016725" ]

0

1

0

[ "Bacteria" ]

[ 36 ]

1

[]

0

true

Family

Vibrio cholerae RfbT

V_cholerae_RfbT

8

IPR008891

8,891

Viral nucleic acid binding

Viral_NABP

Family

880

false

This family is common to ssRNA positive-strand viruses and are commonly described as nucleic acid binding proteins (NABP).

[]

0

[ "PFAM" ]

[ "PF05515" ]

[ "Viral_NABP" ]

[ 880 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Heliantheae alliance", "Tymovirales" ]

[ 14, 866 ]

2

[]

0

true

Family

Viral nucleic acid binding

Viral_NABP

5

IPR008892

8,892

Cold-regulated 413 protein

COR413

Family

2,222

false

This entry represents a group of plant multispanning transmembrane proteins that are regulated by cold. This family can be classified into two groups: the cold-regulated (COR)413-plasma membrane and COR413-thylakoid membrane groups. Proteins in this family have a highly conserved phosphorylation site and a glycosylphos...

[ "GO:0016020" ]

[ "membrane" ]

[ "cellular_component" ]

1

[ "PFAM", "PANTHER" ]

[ "PF05562", "PTHR33596" ]

[ "WCOR413", "" ]

[ 2219, 2117 ]

2

[]

0

[]

0

[ "PUB00020551", "PUB00077044" ]

[ "12746512", "18643950" ]

[ "Expression profiling and bioinformatic analyses of a novel stress-regulated multispanning transmembrane protein family from cereals and Arabidopsis.", "Identification and characterization of Cor413im proteins as novel components of the chloroplast inner envelope." ]

[ 2003, 2008 ]

2

[]

0

null

[ "Eukaryota", "Photorhabdus khanii" ]

[ 2221, 1 ]

2

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 20, 7, 47 ]

3

true

Family

Cold-regulated 413 protein

COR413

5

IPR008893

8,893

WGR domain

WGR_domain

Domain

15,468

false

This domain is named after the most conserved central motif of the domain. It is found in a variety of polyA polymerases as well as the Escherichia coli molybdate metabolism regulator and other proteins of unknown function. The domain is found in isolation in proteins such as and is between 70 and 90 residues in length...

[]

0

[ "PFAM", "PROFILE", "SMART" ]

[ "PF05406", "PS51977", "SM00773" ]

[ "WGR", "WGR", "WGR" ]

[ 14751, 14461, 13486 ]

3

[ "EC", "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "...

[ "2.4.2.-", "2.4.2.30", "PWY-5381", "PWY-5800", "PWY-6148", "PWY-6720", "PWY-7018", "PWY-7025", "PWY-7450", "PWY-7817", "PWY-7981", "R-CEL-5696394", "R-CEL-5696395", "R-CEL-5696400", "R-DME-110362", "R-DME-2173795", "R-DME-3108214", "R-DME-5685939", "R-DME-5696394", "R-DME-56963...

[ "EC:2.4.2.-", "EC:2.4.2.30", "METACYC:PWY-5381", "METACYC:PWY-5800", "METACYC:PWY-6148", "METACYC:PWY-6720", "METACYC:PWY-7018", "METACYC:PWY-7025", "METACYC:PWY-7450", "METACYC:PWY-7817", "METACYC:PWY-7981", "REACTOME:R-CEL-5696394", "REACTOME:R-CEL-5696395", "REACTOME:R-CEL-5696400", "...

48

[ "2cr9", "2eoc", "2ra8", "4dqy", "4opx", "4oqa", "4oqb", "6f1k", "6f5b", "6f5f", "6usj", "6x0l", "6x0m", "6x0n", "7aeo", "7s68", "7s6h", "7s6m", "7s81", "8g0h" ]

20

[ "PUB00075212", "PUB00100920", "PUB00100921" ]

[ "24928857", "22582261", "30321391" ]

[ "PARP-2 and PARP-3 are selectively activated by 5' phosphorylated DNA breaks through an allosteric regulatory mechanism shared with PARP-1.", "Structural basis for DNA damage-dependent poly(ADP-ribosyl)ation by human PARP-1.", "Structural basis for DNA break recognition by ARTD2/PARP2." ]

[ 2014, 2012, 2018 ]

3

[]

[ "IPR049809" ]

0

1

0

[ "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 5871, 9507, 36, 54 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus",...

[ 19, 3, 6, 1, 2, 11, 14, 1, 7, 8, 18 ]

11

true

Domain

WGR domain

WGR_domain

4

IPR008894

8,894

Sugar 3,4-ketoisomerase QdtA, cupin domain

QdtA_cupin_dom

Domain

4,536

false

This entry represents cupin domain found in several bacterial proteins homologous to sugar 3,4-ketoisomerases. Thermoanaerobacterium thermosaccharolyticum QdtA catalyzes a key step in the biosynthesis of these sugars, the conversion of thymidine diphosphate (dTDP)-4-keto-6-deoxyglucose to dTDP-3-keto-6-deoxyglucose [ ]...

[]

0

[ "PFAM", "CDD" ]

[ "PF05523", "cd20292" ]

[ "FdtA", "cupin_QdtA-like" ]

[ 4536, 4095 ]

2

[]

0

[ "2pa7", "2pae", "2pak", "2pam", "4mzu", "4o9e", "4o9g", "4zu4", "4zu5", "4zu7", "5tpu", "5tpv", "7n67" ]

13

[ "PUB00003929", "PUB00016787", "PUB00019541", "PUB00019542", "PUB00096048", "PUB00096049" ]

[ "8612079", "14697267", "12740380", "11589581", "24128043", "24616215" ]

[ "The x-ray crystal structure of phosphomannose isomerase from Candida albicans at 1.7 angstrom resolution.", "Cupins: the most functionally diverse protein superfamily?", "Biosynthesis of dTDP-3-acetamido-3,6-dideoxy-alpha-D-galactose in Aneurinibacillus thermoaerophilus L420-91T.", "Lipopolysaccharide biosyn...

[ 1996, 2004, 2003, 2001, 2013, 2014 ]

6

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Streptomyces phage Zuko", "metagenomes" ]

[ 24, 4422, 4, 1, 85 ]

5

[]

0

true

Domain

Sugar 3,4-ketoisomerase QdtA, cupin domain

QdtA_cupin_dom

3

IPR008897

8,897

Yeast trans-acting factor

Rep_fungi

Family

32

false

The majority of laboratory strains of S. cerevisiae contain 2-micron circle plasmids. 2-micron circle plasmids encode four open reading frames (FLP1, RAF1, REP1, and REP2) and three well known cis-acting sequences, ORI, FRT, and STB. Rep proteins, including Rep1 and Rep12, are part of the plasmid partitioning system th...

[ "GO:0030541" ]

[ "plasmid partitioning" ]

[ "biological_process" ]

1

[ "PFAM" ]

[ "PF05797" ]

[ "Rep_4" ]

[ 32 ]

1

[]

0

[]

0

[ "PUB00074958", "PUB00074959" ]

[ "2832156", "23541845" ]

[ "Antagonistic controls regulate copy number of the yeast 2 mu plasmid.", "The 2 micron plasmid of Saccharomyces cerevisiae: a miniaturized selfish genome with optimized functional competence." ]

[ 1987, 2013 ]

2

[]

0

null

[ "Bacteria", "Saccharomycetaceae" ]

[ 12, 20 ]

2

[ "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)" ]

[ 1 ]

1

true

Family

Yeast trans-acting factor

Rep_fungi

3

IPR008898

8,898

YopD-like

Family

159

false

This family consists of several bacterial YopD like proteins. Virulent Yersinia species harbour a common plasmid that encodes essential virulence determinants (Yersinia outer proteins [Yops]), which are regulated by the extracellular stimuli Ca 2+ and temperature. YopD, also known as Type 3 secretion system translocon ...

[]

0

[ "PFAM" ]

[ "PF05844" ]

[ "YopD" ]

[ 159 ]

1

[ "GP" ]

[ "GenProp0052" ]

[ "GP:GenProp0052" ]

1

[ "1kdl" ]

1

[ "PUB00007795", "PUB00011518", "PUB00151497" ]

[ "10476031", "8418066", "10581252" ]

[ "Insertion of a Yop translocation pore into the macrophage plasma membrane by Yersinia enterocolitica: requirement for translocators YopB and YopD, but not LcrG.", "YopB and YopD constitute a novel class of Yersinia Yop proteins.", "Yersinia enterocolitica type III secretion-translocation system: channel format...

[ 1999, 1993, 1999 ]

3

[]

0

null

[ "Bacteria" ]

[ 159 ]

1

[]

0

true

Family

YopD-like

7

IPR008899

8,899

Zinc finger, piccolo-type

Znf_piccolo

Domain

2,204

false

Zinc finger (Znf) domains are relatively small protein motifs which contain multiple finger-like protrusions that make tandem contacts with their target molecule. Some of these domains bind zinc, but many do not; instead binding other metals such as iron, or no metal at all. For example, some family members form salt b...

[ "GO:0046872", "GO:0045202" ]

[ "metal ion binding", "synapse" ]

[ "molecular_function", "cellular_component" ]

2

[ "PFAM" ]

[ "PF05715" ]

[ "zf-piccolo" ]

[ 2204 ]

1

[ "REACTOME" ]

[ "R-HSA-9662360" ]

[ "REACTOME:R-HSA-9662360" ]

1

[]

0

[ "PUB00014077", "PUB00035804", "PUB00035805", "PUB00035806", "PUB00035807", "PUB00035812", "PUB00035849", "PUB00035850", "PUB00035851" ]

[ "12665246", "17210253", "15963892", "15718139", "10529348", "11179890", "10707984", "9679147", "14734538" ]

[ "Zinc fingers--folds for many occasions.", "Sticky fingers: zinc-fingers as protein-recognition motifs.", "Multiple modes of RNA recognition by zinc finger proteins.", "Zinc finger proteins: getting a grip on RNA.", "Zinc finger peptides for the regulation of gene expression.", "Zinc finger proteins: new ...

[ 2002, 2007, 2005, 2005, 1999, 2001, 2000, 1998, 2004 ]

9

[]

[ "IPR030627" ]

0

1

0

[ "Bilateria" ]

[ 2204 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 37, 3, 2, 6 ]

4

true

Domain

Zinc finger, piccolo-type

Znf_piccolo

9

IPR008900

8,900

Zona occludens toxin, N-terminal

Zot_N

Domain

2,482

false

This domain is found in bacterial and viral proteins which are very similar to the Zonular occludens toxin (Zot). Zot is elaborated by bacteriophage present in toxigenic strains of Vibrio cholerae. Zot is a single polypeptide chain of 44.8kDa, with the ability to reversibly alter intestinal epithelial tight junctions, ...

[]

0

[ "PFAM" ]

[ "PF05707" ]

[ "Zot" ]

[ 2482 ]

1

[]

0

[ "2r2a" ]

1

[ "PUB00092681" ]

[ "11278543" ]

[ "Zonula occludens toxin structure-function analysis. Identification of the fragment biologically active on tight junctions and of the zonulin receptor binding domain." ]

[ 2001 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "metagenomes" ]

[ 33, 2170, 31, 208, 40 ]

5

[]

0

true

Domain

Zona occludens toxin, N-terminal

Zot_N

3

IPR008901

8,901

Alkaline ceramidase

ACER

Family

9,765

false

This entry consists of several bacterial and eukaryotic ceramidases and homologues with no ceramidase activity. Ceramidases are enzymes involved in regulating cellular levels of ceramides, sphingoid bases, and their phosphates [ , ]. A protein belonging to this group, the fly ortologue, has been reported to regulate sp...

[ "GO:0006672", "GO:0016020" ]

[ "ceramide metabolic process", "membrane" ]

[ "biological_process", "cellular_component" ]

2

[ "PFAM", "PANTHER", "PANTHER" ]

[ "PF05875", "PTHR46139", "PTHR46187" ]

[ "Ceramidase", "", "" ]

[ 9744, 2259, 4744 ]

3

[ "EC", "EC", "GP", "GP", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", ...

[ "3.5.1.-", "3.5.1.23", "GenProp1277", "GenProp1363", "PWY-1822", "PWY-5497", "PWY-5784", "PWY-5846", "PWY-6409", "PWY-6483", "PWY-6899", "PWY-7018", "PWY-7119", "PWY-7403", "PWY-7430", "PWY-7496", "PWY-7571", "PWY-7652", "PWY-7771", "PWY-7821", "PWY-7850", "PWY-8229", "PW...

[ "EC:3.5.1.-", "EC:3.5.1.23", "GP:GenProp1277", "GP:GenProp1363", "METACYC:PWY-1822", "METACYC:PWY-5497", "METACYC:PWY-5784", "METACYC:PWY-5846", "METACYC:PWY-6409", "METACYC:PWY-6483", "METACYC:PWY-6899", "METACYC:PWY-7018", "METACYC:PWY-7119", "METACYC:PWY-7403", "METACYC:PWY-7430", "...

35

[ "6g7o", "6yxh" ]

2

[ "PUB00011519", "PUB00161023", "PUB00161024" ]

[ "11356846", "10702247", "21148295" ]

[ "Cloning and characterization of a novel human alkaline ceramidase. A mammalian enzyme that hydrolyzes phytoceramide.", "Cloning of an alkaline ceramidase from Saccharomyces cerevisiae. An enzyme with reverse (CoA-independent) ceramide synthase activity.", "CDase is a pan-ceramidase in Drosophila." ]

[ 2001, 2000, 2011 ]

3

[]

[ "IPR044219" ]

0

1

0

[ "Bacteria", "Eukaryota", "Methanobacteriati", "Nucleocytoviricota", "unclassified sequences" ]

[ 938, 8748, 18, 2, 59 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 5, 1, 8, 2, 21, 6, 1, 4, 15, 2, 13 ]

11

true

Family

Alkaline ceramidase

ACER

9

IPR008903

8,903

Hemagglutinin component HA-17

HA-17_C_botulinum

Family

36

false

This family consists of Clostridium botulinum haemagglutinin (HA) subcomponent HA-17. C. botulinum type D strain 4947 produces two different sizes of progenitor toxins (M and L) as intact forms without proteolytic processing. The M toxin is composed of neurotoxin (NT) and nontoxic-nonhaemagglutinin (NTNHA), whereas the...

[]

0

[ "PIRSF", "CDD" ]

[ "PIRSF037660", "cd23494" ]

[ "Botulinum_HA-17", "beta-trefoil_Ricin_HA17" ]

[ 33, 36 ]

2

[]

0

[ "2e4m", "3win", "4lo0", "4lo1", "4lo2", "4lo3", "4lo7", "4lo8", "4qd2", "5bp5", "5bqu", "9qce", "9qcm" ]

13

[ "PUB00011521", "PUB00047334", "PUB00091178", "PUB00157783", "PUB00157784", "PUB00157785" ]

[ "8631890", "17581814", "24130488", "8569530", "11713244", "24165130" ]

[ "Genetic characterization of Clostridium botulinum type A containing silent type B neurotoxin gene sequences.", "A novel subunit structure of Clostridium botulinum serotype D toxin complex with three extended arms.", "Structure of a bimodular botulinum neurotoxin complex provides insights into its oral toxicity...

[ 1996, 2007, 2013, 1995, 2002, 2013 ]

6

[]

0

null

[ "Clostridium", "unclassified Caudoviricetes" ]

[ 32, 4 ]

2

[]

0

true

Family

Hemagglutinin component HA-17

HA-17_C_botulinum

2

IPR008905

8,905

Eukaryotic translation initiation factor 3 subunit C, N-terminal domain

EIF3C_N_dom

Domain

5,643

false

The largest of the mammalian translation initiation factors, eIF3, consists of at least eight subunits ranging in mass from 35 to 170kDa. eIF3 binds to the 40 S ribosome in an early step of translation initiation and promotes the binding of methionyl-tRNAi and mRNA [ ]. The N-terminal domain of eukaryotic translation i...

[ "GO:0003743", "GO:0031369", "GO:0006413", "GO:0005852" ]

[ "translation initiation factor activity", "translation initiation factor binding", "translational initiation", "eukaryotic translation initiation factor 3 complex" ]

[ "molecular_function", "molecular_function", "biological_process", "cellular_component" ]

4

[ "PFAM" ]

[ "PF05470" ]

[ "eIF-3c_N" ]

[ 5643 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-156827", "R-BTA-72649", "R-BTA-72689", "R-BTA-72695", "R-BTA-72702", "R-CEL-156827", "R-CEL-72649", "R-CEL-72689", "R-CEL-72695", "R-CEL-72702", "R-DDI-156827", "R-DDI-72689", "R-DDI-72695", "R-DDI-72702", "R-DME-156827", "R-DME-72649", "R-DME-72689", "R-DME-72695", "R-DME...

[ "REACTOME:R-BTA-156827", "REACTOME:R-BTA-72649", "REACTOME:R-BTA-72689", "REACTOME:R-BTA-72695", "REACTOME:R-BTA-72702", "REACTOME:R-CEL-156827", "REACTOME:R-CEL-72649", "REACTOME:R-CEL-72689", "REACTOME:R-CEL-72695", "REACTOME:R-CEL-72702", "REACTOME:R-DDI-156827", "REACTOME:R-DDI-72689", "...

54

[ "3j8b", "3j8c", "3jap", "4u1c", "4uer", "5a5t", "5h7u", "6fec", "6fyx", "6fyy", "6gsm", "6gsn", "6w2s", "6w2t", "6yam", "6ybd", "6ybw", "6zce", "6zmw", "6zon", "6zp4", "6zu9", "6zvj", "7a09", "7ase", "7qp6", "7qp7", "8cah", "8cas", "8oz0", "8pj1", "8pj2"...

43

[ "PUB00005773", "PUB00064784" ]

[ "8995409", "22718758" ]

[ "Conservation and diversity of eukaryotic translation initiation factor eIF3.", "Functional characterization of the role of the N-terminal domain of the c/Nip1 subunit of eukaryotic initiation factor 3 (eIF3) in AUG recognition." ]

[ 1997, 2012 ]

2

[]

0

null

[ "Eukaryota", "bird metagenome" ]

[ 5641, 2 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 11, 1, 3, 2, 13, 9, 1, 7, 3, 1, 1, 25 ]

12

true

Domain

Eukaryotic translation initiation factor 3 subunit C, N-terminal domain

EIF3C_N_dom

1

IPR008906

8,906

HAT, C-terminal dimerisation domain

HATC_C_dom

Domain

71,221

false

This dimerisation domain is found at the C terminus of the transposases of elements belonging to the Activator superfamily (hAT element superfamily). The isolated dimerisation domain forms extremely stable dimers in vitro [ , ].

[ "GO:0046983" ]

[ "protein dimerization activity" ]

[ "molecular_function" ]

1

[ "PFAM" ]

[ "PF05699" ]

[ "Dimer_Tnp_hAT" ]

[ 71221 ]

1

[ "REACTOME" ]

[ "R-HSA-4551638" ]

[ "REACTOME:R-HSA-4551638" ]

1

[ "2bw3", "4d1q", "6dww", "6dwy", "6dwz", "6dx0", "8edg", "8sjd" ]

8

[ "PUB00011522", "PUB00019671" ]

[ "10662858", "11454746" ]

[ "A highly conserved domain of the maize activator transposase is involved in dimerization.", "Structure and evolution of the hAT transposon superfamily." ]

[ 2000, 2001 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "Pandoravirus" ]

[ 3, 71203, 15 ]

3

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 157, 9, 37, 4, 12, 13, 259, 8, 230 ]

9

true

Domain

HAT, C-terminal dimerisation domain

HATC_C_dom

6

IPR008907

8,907

Tubulin polymerization-promoting protein

TPP/p25

Family

4,929

false

This family includes Tubulin polymerization-promoting proteins, formerly known as 25kDa proteins (TPPP/p25) that are phosphorylated by a Ser/Thr-Pro kinase [ ]. Proteins in this family, including TPP and TPP3 from human, are regulators of microtubule dynamics [ , ]. TPP plays a key role in myelination by promoting elon...

[ "GO:0015631", "GO:0046785" ]

[ "tubulin binding", "microtubule polymerization" ]

[ "molecular_function", "biological_process" ]

2

[ "PFAM", "PANTHER" ]

[ "PF05517", "PTHR12932" ]

[ "p25-alpha", "" ]

[ 4867, 4298 ]

2

[]

0

[ "1pul", "1wlm", "2jrf", "9j4d", "9j4e", "9j4f" ]

6

[ "PUB00011523", "PUB00101512", "PUB00101513", "PUB00101514" ]

[ "1909972", "33831707", "31522887", "30667362" ]

[ "A novel brain-specific 25 kDa protein (p25) is phosphorylated by a Ser/Thr-Pro kinase (TPK II) from tau protein kinase fractions.", "Regulation of the tubulin polymerization-promoting protein by Ca<sup>2+</sup>/S100 proteins.", "The Golgi Outpost Protein TPPP Nucleates Microtubules and Is Critical for Myelinat...

[ 1991, 2021, 2019, 2019 ]

4

[]

0

null

[ "Eukaryota", "Streptomyces parvus" ]

[ 4928, 1 ]

2

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 5, 2, 9, 5, 11 ]

6

true

Family

Tubulin polymerization-promoting protein

TPP/p25

8

IPR008908

8,908

Sarcoglycan alpha/epsilon

Sarcoglycan_alpha/epsilon

Family

4,037

false

This entry contains alpha and epsilon sarcoglycans. The sarcoglycan family proteins are single pass transmembrane proteins that are part of the dystrophin-associated glycoprotein complex (DGC), a multiprotein complex that links the actin cytoskeleton to the extracellular matrix in cardiac and skeletal muscle [ ]. The D...

[ "GO:0016012" ]

[ "sarcoglycan complex" ]

[ "cellular_component" ]

1

[ "PANTHER" ]

[ "PTHR10132" ]

[ "" ]

[ 4037 ]

1

[ "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-9913351", "R-MMU-9913351", "R-RNO-9913351" ]

[ "REACTOME:R-HSA-9913351", "REACTOME:R-MMU-9913351", "REACTOME:R-RNO-9913351" ]

3

[ "8yt8", "9c3c" ]

2

[ "PUB00073492", "PUB00073982" ]

[ "11917091", "17200151" ]

[ "Function and genetics of dystrophin and dystrophin-related proteins in muscle.", "SGCE missense mutations that cause myoclonus-dystonia syndrome impair epsilon-sarcoglycan trafficking to the plasma membrane: modulation by ubiquitination and torsinA." ]

[ 2002, 2007 ]

2

[]

0

null

[ "Eumetazoa" ]

[ 4037 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 14, 4, 61, 13, 11 ]

6

true

Family

Sarcoglycan alpha/epsilon

Sarcoglycan_alpha/epsilon

1

IPR008909

8,909

DALR anticodon binding

DALR_anticod-bd

Domain

55,409

false

Aminoacyl-tRNA synthetase (aaRS) is a key enzyme during protein biosynthesis. Each aaRS contains a catalytic central domain (CCD), responsible for activating amino acid, and an anticodon-binding domain (ABD), necessary for binding the anticodon in cognate tRNA. aaRSs are classified into class I and II (aaRS-I and aaRS-...

[ "GO:0004814", "GO:0005524", "GO:0006420" ]

[ "arginine-tRNA ligase activity", "ATP binding", "arginyl-tRNA aminoacylation" ]

[ "molecular_function", "molecular_function", "biological_process" ]

3

[ "PFAM", "SMART" ]

[ "PF05746", "SM00836" ]

[ "DALR_1", "DALR_1" ]

[ 55098, 43774 ]

2

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "6.1.1.19", "R-BTA-9856649", "R-DME-9856649", "R-HSA-2408522", "R-HSA-379716", "R-HSA-379726", "R-HSA-9856649", "R-MMU-9856649", "R-RNO-9856649" ]

[ "EC:6.1.1.19", "REACTOME:R-BTA-9856649", "REACTOME:R-DME-9856649", "REACTOME:R-HSA-2408522", "REACTOME:R-HSA-379716", "REACTOME:R-HSA-379726", "REACTOME:R-HSA-9856649", "REACTOME:R-MMU-9856649", "REACTOME:R-RNO-9856649" ]

9

[ "1bs2", "1f7u", "1f7v", "1iq0", "2zue", "2zuf", "3fnr", "4oby", "4q2t", "4q2x", "4q2y", "4r3z", "4zaj", "5b63", "5jld", "5yym", "5yyn", "6ao8", "7xjy", "7xjz", "7xk0", "7xk1", "7xof", "7yse", "8h1c", "8ie2" ]

26

[ "PUB00007363", "PUB00069766" ]

[ "10447505", "15733854" ]

[ "Evolution of aminoacyl-tRNA synthetases--analysis of unique domain architectures and phylogenetic trees reveals a complex history of horizontal gene transfer events.", "Evolution of different oligomeric glycyl-tRNA synthetases." ]

[ 1999, 2005 ]

2

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Megaviricetes", "unclassified sequences" ]

[ 935, 43305, 10316, 35, 818 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus",...

[ 16, 3, 6, 4, 2, 16, 5, 1, 8, 8, 2, 1, 17 ]

13

true

Domain

DALR anticodon binding

DALR_anticod-bd

7

IPR008911

8,911

Short scorpion toxin, potassium channel inhibitor alpha-KTx 8/9

Toxin_alpha-KTx_8/9

Family

37

false

Scorpion toxins that target K+ channels (KTx) have been classified into four large families: alpha, beta, gamma and kappa-KTx [ ]. This family consists of toxin-like peptides from the alpha-KTx 8 and alpha-KTx 9 subfamilies. The precursor of these toxins consists of 60 amino acid residues, with a putative signal peptid...

[ "GO:0008200", "GO:0005576" ]

[ "ion channel inhibitor activity", "extracellular region" ]

[ "molecular_function", "cellular_component" ]

2

[ "PFAM" ]

[ "PF05453" ]

[ "Toxin_6" ]

[ 37 ]

1

[]

0

[ "1acw", "1du9", "1wm7", "1wm8", "2ktc" ]

5

[ "PUB00020452", "PUB00020453", "PUB00020454", "PUB00075702" ]

[ "11076505", "10471839", "11384716", "15208019" ]

[ "Solution structure of BmP02, a new potassium channel blocker from the venom of the Chinese scorpion Buthus martensi Karsch.", "Molecular cloning and sequencing of two 'short chain' and two 'long chain' K(+) channel-blocking peptides from the Chinese scorpion Buthus martensii Karsch.", "Precursor nucleotide seq...

[ 2000, 1999, 2001, 2004 ]

4

[]

0

null

[ "Buthidae" ]

[ 37 ]

1

[]

0

true

Family

Short scorpion toxin, potassium channel inhibitor alpha-KTx 8/9

Toxin_alpha-KTx_8/9

6

IPR008912

8,912

Regulatory protein ViaA-like, vWA domain

ViaA-like_vWA

Domain

19,752

false

This entry represents the VWA type domain found in Regulatory protein ViaA and similar sequences. It is found as part of a CO oxidising (Cox) system operon in several bacteria [ ]. ViaA is a component of the RavA-ViaA chaperone complex, which may act on the membrane to optimise the function of some of the respiratory c...

[]

0

[ "PFAM" ]

[ "PF05762" ]

[ "VWA_CoxE" ]

[ 19752 ]

1

[]

0

[]

0

[ "PUB00011525" ]

[ "10433972" ]

[ "Sequence analysis, characterization and CO-specific transcription of the cox gene cluster on the megaplasmid pHCG3 of Oligotropha carboxidovorans." ]

[ 1999 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 214, 19155, 57, 2, 324 ]

5

[ "Escherichia coli (strain K12)" ]

[ 2 ]

1

true

Domain

Regulatory protein ViaA-like, vWA domain

ViaA-like_vWA

3

IPR008913

8,913

Zinc finger, CHY-type

Znf_CHY

Domain

13,280

false

Zinc finger (Znf) domains are relatively small protein motifs which contain multiple finger-like protrusions that make tandem contacts with their target molecule. Some of these domains bind zinc, but many do not; instead binding other metals such as iron, or no metal at all. For example, some family members form salt b...

[ "GO:0008270" ]

[ "zinc ion binding" ]

[ "molecular_function" ]

1

[ "PFAM", "PROFILE" ]

[ "PF05495", "PS51266" ]

[ "zf-CHY", "ZF_CHY" ]

[ 12644, 13163 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-110320", "R-HSA-983168", "R-MMU-110320", "R-MMU-983168" ]

[ "REACTOME:R-HSA-110320", "REACTOME:R-HSA-983168", "REACTOME:R-MMU-110320", "REACTOME:R-MMU-983168" ]

4

[ "2dkt", "2k2c", "7ynx" ]

3

[ "PUB00014077", "PUB00017071", "PUB00035804", "PUB00035805", "PUB00035806", "PUB00035807", "PUB00035812", "PUB00043738" ]

[ "12665246", "15294910", "17210253", "15963892", "15718139", "10529348", "11179890", "12654245" ]

[ "Zinc fingers--folds for many occasions.", "The role of Hot13p and redox chemistry in the mitochondrial TIM22 import pathway.", "Sticky fingers: zinc-fingers as protein-recognition motifs.", "Multiple modes of RNA recognition by zinc finger proteins.", "Zinc finger proteins: getting a grip on RNA.", "Zinc...

[ 2002, 2004, 2007, 2005, 2005, 1999, 2001, 2003 ]

8

[]

0

null

[ "Bacteria", "Eukaryota", "Halobacteriales", "Viruses", "metagenomes" ]

[ 1489, 11588, 176, 17, 10 ]

5

[ "Arabidopsis thaliana", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "...

[ 35, 5, 2, 6, 2, 3, 23, 5, 1, 4, 78 ]

11

true

Domain

Zinc finger, CHY-type

Znf_CHY

4

IPR008914

8,914

Phosphatidylethanolamine-binding protein

PEBP

Family

37,514

false

The PEBP (PhosphatidylEthanolamine-Binding Protein) family is a highly conserved group of proteins that have been identified in numerous tissues in a wide variety of organisms, including bacteria, yeast, nematodes, plants, drosophila and mammals. The various functions described for members of this family include lipid ...

[]

0

[ "PFAM" ]

[ "PF01161" ]

[ "PBP" ]

[ 37514 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-5389840", "R-BTA-5419276", "R-BTA-5674135", "R-BTA-5675221", "R-BTA-9937383", "R-CEL-5674135", "R-CEL-5675221", "R-CFA-5674135", "R-CFA-5675221", "R-HSA-5368286", "R-HSA-5389840", "R-HSA-5419276", "R-HSA-5674135", "R-HSA-5675221", "R-HSA-6802946", "R-HSA-6802948", "R-HSA-68029...

[ "REACTOME:R-BTA-5389840", "REACTOME:R-BTA-5419276", "REACTOME:R-BTA-5674135", "REACTOME:R-BTA-5675221", "REACTOME:R-BTA-9937383", "REACTOME:R-CEL-5674135", "REACTOME:R-CEL-5675221", "REACTOME:R-CFA-5674135", "REACTOME:R-CFA-5675221", "REACTOME:R-HSA-5368286", "REACTOME:R-HSA-5389840", "REACTOM...

30

[ "1a44", "1b7a", "1bd9", "1beh", "1fjj", "1fux", "1kn3", "1qou", "1vi3", "1wko", "1wkp", "1wpx", "2evv", "2gzq", "2iqx", "2iqy", "2jyz", "2l7w", "2qyq", "2r77", "3axy", "3j6b", "3j7y", "3j9m", "3n08", "4beg", "4ce4", "4v1a", "5aj4", "5mrc", "5mre", "5mrf"...

131

[ "PUB00010657", "PUB00010659", "PUB00010660", "PUB00010662", "PUB00010663", "PUB00015041" ]

[ "12492898", "11034991", "10764580", "12551925", "11585904", "11439028" ]

[ "Peptides corresponding to the N- and C-terminal parts of PEBP are well-structured in solution: new insights into their possible interaction with partners in vivo.", "The phosphatidylethanolamine-binding protein is the prototype of a novel family of serine protease inhibitors.", "The structure of Antirrhinum ce...

[ 2003, 2001, 2000, 2003, 2001, 2001 ]

6

[]

[ "IPR005247", "IPR035810", "IPR049556" ]

0

3

0

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 690, 17120, 19434, 36, 234 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus",...

[ 32, 4, 5, 9, 2, 10, 9, 3, 53, 14, 3, 1, 74 ]

13

true

Family

Phosphatidylethanolamine-binding protein

PEBP

1

IPR008915

8,915

Peptidase M50

Peptidase_M50

Domain

56,020

false

Over 70 metallopeptidase families have been identified to date. In these enzymes a divalent cation, which is usually zinc but may be cobalt, manganese or copper, activates the water molecule. The metal ion is held in place by amino acid ligands, usually three in number. In some families of co-catalytic metallopeptidase...

[ "GO:0006508" ]

[ "proteolysis" ]

[ "biological_process" ]

1

[ "PFAM" ]

[ "PF02163" ]

[ "Peptidase_M50" ]

[ 56020 ]

1

[ "EC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "3.4.24.-", "PWY-8119", "R-BTA-1655829", "R-BTA-381033", "R-BTA-8874177", "R-BTA-8874211", "R-HSA-1655829", "R-HSA-381033", "R-HSA-8874177", "R-HSA-8874211", "R-HSA-8963889", "R-MMU-1655829", "R-MMU-381033", "R-MMU-8874177", "R-MMU-8874211" ]

[ "EC:3.4.24.-", "METACYC:PWY-8119", "REACTOME:R-BTA-1655829", "REACTOME:R-BTA-381033", "REACTOME:R-BTA-8874177", "REACTOME:R-BTA-8874211", "REACTOME:R-HSA-1655829", "REACTOME:R-HSA-381033", "REACTOME:R-HSA-8874177", "REACTOME:R-HSA-8874211", "REACTOME:R-HSA-8963889", "REACTOME:R-MMU-1655829", ...

15

[ "3b4r", "7w6x", "7w6y", "7w6z", "8vjl", "8vjm", "9j82", "9j83" ]

8

[ "PUB00003579" ]

[ "7674922" ]

[ "Evolutionary families of metallopeptidases." ]

[ 1995 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences", "uncultured Caudovirales phage" ]

[ 2479, 47038, 5294, 1207, 2 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 41, 1, 2, 1, 1, 3, 3, 7, 3, 44 ]

10

true

Domain

Peptidase M50

Peptidase_M50

1