interpro_id string | interpro_numeric_id int64 | name string | short_name string | entry_type string | protein_count int64 | is_llm bool | is_llm_reviewed bool | abstract string | go_ids list | go_terms list | go_categories list | go_count int64 | member_databases list | member_accessions list | member_names list | member_protein_counts list | member_count int64 | external_databases list | external_accessions list | external_xrefs list | external_xref_count int64 | pdb_ids list | structure_count int64 | publication_ids list | pubmed_ids list | publication_titles list | publication_years list | publication_count int64 | parent_ids list | child_ids list | parent_count int64 | child_count int64 | tree_depth float64 | taxonomy_names list | taxonomy_protein_counts list | taxonomy_count int64 | key_species_names list | key_species_protein_counts list | key_species_count int64 | in_entry_list bool | entry_list_type string | entry_list_name string | names_dat_name string | short_names_dat_name string | split_bucket int64 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
IPR009075 | 9,075 | Acyl-CoA dehydrogenase/oxidase, C-terminal | AcylCo_DH/oxidase_C | Domain | 295,553 | false | false | Acyl-CoA dehydrogenases ( ) are a family of flavoproteins that catalyse the alpha,beta-dehydrogenation of acyl-CoA thioesters to the corresponding trans 2,3-enoyl CoA-products with the concomitant reduction of enzyme-bound FAD. Different family members share a high sequence identity, catalytic mechanisms, and structura... | [
"GO:0016627"
] | [
"oxidoreductase activity, acting on the CH-CH group of donors"
] | [
"molecular_function"
] | 1 | [
"PFAM"
] | [
"PF00441"
] | [
"Acyl-CoA_dh_1"
] | [
295553
] | 1 | [
"EC",
"GP",
"GP",
"GP",
"GP",
"GP",
"GP",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
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"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"1.3.8",
"GenProp1510",
"GenProp1533",
"GenProp1562",
"GenProp1572",
"GenProp1673",
"GenProp1717",
"R-BTA-70895",
"R-BTA-71064",
"R-BTA-77288",
"R-BTA-77305",
"R-BTA-77346",
"R-BTA-77348",
"R-BTA-9837999",
"R-CEL-71064",
"R-DDI-70895",
"R-DDI-71064",
"R-DDI-9837999",
"R-DME-77288... | [
"EC:1.3.8",
"GP:GenProp1510",
"GP:GenProp1533",
"GP:GenProp1562",
"GP:GenProp1572",
"GP:GenProp1673",
"GP:GenProp1717",
"REACTOME:R-BTA-70895",
"REACTOME:R-BTA-71064",
"REACTOME:R-BTA-77288",
"REACTOME:R-BTA-77305",
"REACTOME:R-BTA-77346",
"REACTOME:R-BTA-77348",
"REACTOME:R-BTA-9837999",
... | 67 | [
"1buc",
"1egc",
"1egd",
"1ege",
"1ivh",
"1jqi",
"1r2j",
"1rx0",
"1siq",
"1sir",
"1t9g",
"1udy",
"1ukw",
"1ws9",
"2a1t",
"2c0u",
"2c12",
"2cx9",
"2d29",
"2dvl",
"2eba",
"2ix5",
"2ix6",
"2jif",
"2pg0",
"2r0m",
"2r0n",
"2reh",
"2uxw",
"2vig",
"2wbi",
"2z1q"... | 153 | [
"PUB00013228",
"PUB00013229",
"PUB00020979",
"PUB00020980",
"PUB00026133"
] | [
"11812788",
"9214289",
"14728675",
"14728676",
"11872165"
] | [
"Crystal structure of rat short chain acyl-CoA dehydrogenase complexed with acetoacetyl-CoA: comparison with other acyl-CoA dehydrogenases.",
"Structure of human isovaleryl-CoA dehydrogenase at 2.6 A resolution: structural basis for substrate specificity,.",
"Acyl-CoA dehydrogenases and acyl-CoA oxidases. Struc... | [
2002,
1997,
2004,
2004,
2002
] | 5 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Sym plasmid",
"Viruses",
"unclassified sequences"
] | [
3818,
244142,
43401,
3,
4,
4185
] | 6 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
14,
19,
20,
12,
4,
88,
30,
8,
15,
53,
38
] | 11 | true | Domain | Acyl-CoA dehydrogenase/oxidase, C-terminal | Acyl-CoA dehydrogenase/oxidase, C-terminal | AcylCo_DH/oxidase_C | 3 |
IPR009076 | 9,076 | FKBP12-rapamycin binding domain | FRB_dom | Domain | 5,617 | false | false | The macrolide antibiotic rapamycin and the cytosol protein FKBP12 can form a complex which specifically inhibits the TORC1 complex, leading to growth arrest. The FKBP12-rapamycin complex interferes with TORC1 function by binding to the FKBP12-rapamycin binding domain (FRB) of the Tor proteins. In budding yeast, the Tor... | [
"GO:0044877"
] | [
"protein-containing complex binding"
] | [
"molecular_function"
] | 1 | [
"PFAM"
] | [
"PF08771"
] | [
"FRB_dom"
] | [
5617
] | 1 | [
"EC",
"REACTOME",
"REACTOME",
"REACTOME",
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"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
... | [
"2.7.11.1",
"R-CEL-1257604",
"R-CEL-1632852",
"R-CEL-165159",
"R-CEL-166208",
"R-CEL-3371571",
"R-CEL-380972",
"R-CEL-389357",
"R-CEL-5218920",
"R-CEL-5628897",
"R-CEL-6804757",
"R-CEL-8943724",
"R-CEL-9639288",
"R-CEL-9856530",
"R-DDI-1257604",
"R-DDI-1632852",
"R-DDI-165159",
"R-... | [
"EC:2.7.11.1",
"REACTOME:R-CEL-1257604",
"REACTOME:R-CEL-1632852",
"REACTOME:R-CEL-165159",
"REACTOME:R-CEL-166208",
"REACTOME:R-CEL-3371571",
"REACTOME:R-CEL-380972",
"REACTOME:R-CEL-389357",
"REACTOME:R-CEL-5218920",
"REACTOME:R-CEL-5628897",
"REACTOME:R-CEL-6804757",
"REACTOME:R-CEL-8943724... | 93 | [
"1aue",
"1fap",
"1nsg",
"2fap",
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"3fap",
"3jbz",
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"5wby",
"5zcs",
"6bcu",
"6bcx",
"6emk",
"6m4u",
"6m4w"... | 74 | [
"PUB00013231",
"PUB00061649",
"PUB00078108",
"PUB00078109"
] | [
"8662507",
"15689497",
"26700129",
"26028537"
] | [
"Structure of the FKBP12-rapamycin complex interacting with the binding domain of human FRAP.",
"The pleckstrin homology domain proteins Slm1 and Slm2 are required for actin cytoskeleton organization in yeast and bind phosphatidylinositol-4,5-bisphosphate and TORC2.",
"Ubiquitin regulates TORC1 in yeast Sacchar... | [
1996,
2005,
2015,
2015
] | 4 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Insolitispirillum peregrinum"
] | [
5616,
1
] | 2 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
5,
1,
2,
6,
6,
1,
1,
2,
6,
2,
2,
15
] | 12 | true | Domain | FKBP12-rapamycin binding domain | FKBP12-rapamycin binding domain | FRB_dom | 4 |
IPR009077 | 9,077 | Proteasome activator PA28 | Proteasome_activ_PA28 | Family | 4,725 | false | false | The 20S proteasome is a multicatalytic complex that is responsible for the non-lysosomal degradation of intracellular proteins. The proteasome is composed of a catalytic core that is regulated by protein complexes, which bind to the ends of the cylindrical core structure. One of these regulatory complexes is the PA28 a... | [
"GO:0008537"
] | [
"proteasome activator complex"
] | [
"cellular_component"
] | 1 | [
"PANTHER"
] | [
"PTHR10660"
] | [
""
] | [
4725
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
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"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-1236974",
"R-BTA-1236978",
"R-BTA-9907900",
"R-BTA-9912633",
"R-DDI-1236974",
"R-DDI-1236978",
"R-DDI-9907900",
"R-DDI-9912633",
"R-GGA-9907900",
"R-HSA-1236974",
"R-HSA-1236978",
"R-HSA-8950505",
"R-HSA-9907900",
"R-HSA-9912633",
"R-MMU-1236974",
"R-MMU-1236978",
"R-MMU-99079... | [
"REACTOME:R-BTA-1236974",
"REACTOME:R-BTA-1236978",
"REACTOME:R-BTA-9907900",
"REACTOME:R-BTA-9912633",
"REACTOME:R-DDI-1236974",
"REACTOME:R-DDI-1236978",
"REACTOME:R-DDI-9907900",
"REACTOME:R-DDI-9912633",
"REACTOME:R-GGA-9907900",
"REACTOME:R-HSA-1236974",
"REACTOME:R-HSA-1236978",
"REACTOM... | 26 | [
"1avo",
"5msj",
"5msk",
"5mx5",
"6dfk",
"6muv",
"6mux",
"7dr6",
"7drw",
"7nao",
"7nap",
"7yqc",
"7yqd",
"8cxb"
] | 14 | [
"PUB00013234"
] | [
"9403698"
] | [
"Structure of the proteasome activator REGalpha (PA28alpha)."
] | [
1997
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Rhodobacter flavimaris"
] | [
4724,
1
] | 2 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
3,
1,
26,
17,
23
] | 6 | true | Family | Proteasome activator PA28 | Proteasome activator PA28 | Proteasome_activ_PA28 | 9 |
IPR009078 | 9,078 | Ferritin-like superfamily | Ferritin-like_SF | Homologous_superfamily | 237,466 | false | false | Ferritin is one of the major non-haem iron storage proteins in animals, plants, and microorganisms. It is a multisubunit protein with a hollow interior, which contains a mineral core of hydrated ferric oxide, thereby ensuring its solubility in an aqueous environment [ ]. Each subunit consists of a closed, four-helical ... | [] | [] | [] | 0 | [
"SSF"
] | [
"SSF47240"
] | [
""
] | [
237466
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
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"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-6798695",
"R-BTA-917937",
"R-CEL-2142789",
"R-CEL-499943",
"R-CFA-432722",
"R-CFA-6798695",
"R-CFA-917937",
"R-DDI-2142789",
"R-DDI-499943",
"R-DME-499943",
"R-DRE-499943",
"R-GGA-432722",
"R-GGA-6798695",
"R-GGA-917937",
"R-HSA-1222449",
"R-HSA-2142789",
"R-HSA-3000480",
"R... | [
"REACTOME:R-BTA-6798695",
"REACTOME:R-BTA-917937",
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"REACTOME:R-CEL-499943",
"REACTOME:R-CFA-432722",
"REACTOME:R-CFA-6798695",
"REACTOME:R-CFA-917937",
"REACTOME:R-DDI-2142789",
"REACTOME:R-DDI-499943",
"REACTOME:R-DME-499943",
"REACTOME:R-DRE-499943",
"REACTOME:R-GGA... | 38 | [
"1aew",
"1afr",
"1av8",
"1b71",
"1bcf",
"1bfr",
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"1biq",
"1dat",
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"1fz7",
"1fz8",
"1fz9",
"1fzh",
"1fzi",
"1gwg",
"1h0n",
"1h0o"... | 1,279 | [
"PUB00013235",
"PUB00013236",
"PUB00013315"
] | [
"9668036",
"12175244",
"11315567"
] | [
"Localized unfolding at the junction of three ferritin subunits. A mechanism for iron release?",
"X-ray crystal structures of reduced rubrerythrin and its azide adduct: a structure-based mechanism for a non-heme diiron peroxidase.",
"Crystal structures of oxidized dinuclear manganese centres in Mn-substituted c... | [
1998,
2002,
2001
] | 3 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
6353,
189709,
35277,
3069,
3058
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
84,
4,
28,
14,
10,
50,
39,
3,
39,
56,
3,
3,
93
] | 13 | true | Homologous_superfamily | Ferritin-like superfamily | Ferritin-like superfamily | Ferritin-like_SF | 4 |
IPR009079 | 9,079 | Four-helical cytokine-like, core | 4_helix_cytokine-like_core | Homologous_superfamily | 36,309 | false | false | This superfamily contains a domain with a core structure consisting of a closed bundle of four helices in a left-handed twist, with two crossover connections. Proteins containing this domain include long-chain cytokines, such as leukaemia inhibitory factor (LIF) [ ], the growth hormone somatotropin [ ], interleukin-6 [... | [] | [] | [] | 0 | [
"CATHGENE3D",
"CATHGENE3D",
"SSF"
] | [
"G3DSA:1.20.1250.10",
"G3DSA:1.20.1250.70",
"SSF47266"
] | [
"",
"",
""
] | [
33835,
2285,
35460
] | 3 | [
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"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-1059683",
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"R-BTA-1433559",
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"R-BTA-6811558",
"R-BTA-877300",
"R-BTA-877312",
"R-BTA-8957275",
"R-BTA-8983432",
... | [
"REACTOME:R-BTA-1059683",
"REACTOME:R-BTA-110056",
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"REACTOME:R-BTA-1257604",
"REACTOME:R-BTA-1433557",
"REACTOME:R-BTA-1433559",
"REACTOME:R-BTA-381426",
"REACTOME:R-BTA-449836",
"REACTOME:R-BTA-512988",
"REACTOME:R-BTA-5673001",
"REACTOME:R-BTA-6785807",
"REACTOME:R-B... | 237 | [
"1a22",
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"1ete",
"1evs",
"1exz",
"1f45",
"1f6f",
"1fg9",
"1fyh",
"1ga3"... | 340 | [
"PUB00013237",
"PUB00013238",
"PUB00013240",
"PUB00013241",
"PUB00013316",
"PUB00013399"
] | [
"14511776",
"9118960",
"9783743",
"10880433",
"14507421",
"9144295"
] | [
"Gene expression of leukemia inhibitory factor (LIF) and macrophage colony stimulating factor (M-CSF) in bovine endometrium during early pregnancy.",
"1.9 A crystal structure of interleukin 6: implications for a novel mode of receptor dimerization and signaling.",
"NMR structure of human erythropoietin and a co... | [
2003,
1997,
1998,
2000,
2003,
1997
] | 6 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Viruses"
] | [
25,
36012,
272
] | 3 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
81,
232,
249,
282
] | 4 | true | Homologous_superfamily | Four-helical cytokine-like, core | Four-helical cytokine-like, core | 4_helix_cytokine-like_core | 7 |
IPR009083 | 9,083 | Transcription factor IIA, alpha-helical domain | TFIIA_a-hlx | Homologous_superfamily | 4,780 | false | false | Transcription factor IIA (TFIIA) is one of several factors that form part of a transcription pre-initiation complex along with RNA polymerase II, the TATA-box-binding protein (TBP) and TBP-associated factors, on the TATA-box sequence upstream of the initiation start site. After initiation, some components of the pre-in... | [
"GO:0006367",
"GO:0005672"
] | [
"transcription initiation at RNA polymerase II promoter",
"transcription factor TFIIA complex"
] | [
"biological_process",
"cellular_component"
] | 2 | [
"CATHGENE3D"
] | [
"G3DSA:1.10.287.190"
] | [
""
] | [
4780
] | 1 | [
"REACTOME",
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"REACTOM... | [
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"R-DME-674695",
"R-DME-6807505",
"R-DME-73776",
"R-DME-73779",
"R-DME-75953",
... | [
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"REACTOME:R-DDI-73776",
"REACTOME:R-DDI-73779",
"REACTOME:R-DDI-75953",
"REACTOME:R-DDI-76042",
... | 58 | [
"1nh2",
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"1ytf",
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"7eg9",
"7ega",
"7egb",
"7egc"... | 85 | [
"PUB00013248",
"PUB00013320"
] | [
"12818428",
"8610010"
] | [
"TFIIA abrogates the effects of inhibition by HMGB1 but not E1A during the early stages of assembly of the transcriptional preinitiation complex.",
"Crystal structure of a yeast TFIIA/TBP/DNA complex."
] | [
2003,
1996
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
4780
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
4,
2,
1,
4,
5,
9,
1,
4,
11,
1,
1,
7
] | 12 | true | Homologous_superfamily | Transcription factor IIA, alpha-helical domain | Transcription factor IIA, alpha-helical domain | TFIIA_a-hlx | 9 |
IPR009084 | 9,084 | B transposition protein, C-terminal | B_transpositn_C | Domain | 601 | false | false | Bacteriophage Mu can integrate into the host bacterial genome and replicate via transposition. Mu requires the activity of four proteins for DNA transposition. Two of these proteins are the phage-encoded A and B transposition proteins, while the other two are host-specified accessory factors HU and IHF. These four prot... | [
"GO:0003677",
"GO:0006313"
] | [
"DNA binding",
"DNA transposition"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PFAM"
] | [
"PF09077"
] | [
"Phage-MuB_C"
] | [
601
] | 1 | [] | [] | [] | 0 | [
"1f6v",
"8xvb",
"8xvc",
"8xvd"
] | 4 | [
"PUB00013249",
"PUB00013250"
] | [
"12791691",
"11060014"
] | [
"Effect of mutations in the C-terminal domain of Mu B on DNA binding and interactions with Mu A transposase.",
"The solution structure of the C-terminal domain of the Mu B transposition protein."
] | [
2003,
2000
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Caudoviricetes",
"Effrenium voratum",
"viral metagenome"
] | [
592,
6,
1,
2
] | 4 | [] | [] | 0 | true | Domain | B transposition protein, C-terminal | B transposition protein, C-terminal | B_transpositn_C | 5 |
IPR009086 | 9,086 | Bacteriocin AS-48 | Bacteriocin_AS48 | Homologous_superfamily | 295 | false | false | Bacteriocin AS-48 is a cyclic peptide antibiotic produced by the eubacteria Enterococcus faecalis (Streptococcus faecalis) that shows a broad antimicrobial spectrum against both Gram-positive and Gram-negative bacteria. Bacteriocin AS-48 is encoded by the pheromone-responsive plasmid pMB2, and acts on the plasma membra... | [] | [] | [] | 0 | [
"CATHGENE3D"
] | [
"G3DSA:1.20.225.10"
] | [
""
] | [
295
] | 1 | [] | [] | [] | 0 | [
"1e68",
"1o82",
"1o83",
"1o84",
"2kjf",
"2mp8",
"4rgd",
"6o8j",
"6o8p"
] | 9 | [
"PUB00013253"
] | [
"11005847"
] | [
"Bacteriocin AS-48, a microbial cyclic polypeptide structurally and functionally related to mammalian NK-lysin."
] | [
2000
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"bioreactor metagenome"
] | [
294,
1
] | 2 | [] | [] | 0 | true | Homologous_superfamily | Bacteriocin AS-48 | Bacteriocin AS-48 | Bacteriocin_AS48 | 6 |
IPR009087 | 9,087 | Rab geranylgeranyltransferase, alpha subunit, insert-domain | RabGGT_asu_insert-domain | Domain | 733 | false | false | Rab geranylgeranyltransferase (RabGGT) catalyses the transfer of geranylgeranyl groups to the C-terminal cysteine residues of Rab proteins, Ras-related small GTPases that function in intracellular vesicular transport [ ]. RabGGT is only able to prenylate Rab when it is complexed to the Rab escort protein (REP), after w... | [
"GO:0004663",
"GO:0008270"
] | [
"Rab geranylgeranyltransferase activity",
"zinc ion binding"
] | [
"molecular_function",
"molecular_function"
] | 2 | [
"PFAM"
] | [
"PF07711"
] | [
"RabGGT_insert"
] | [
733
] | 1 | [
"EC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"2.5.1.60",
"R-BTA-6803205",
"R-BTA-8873719",
"R-HSA-6803205",
"R-HSA-8873719",
"R-MMU-6803205",
"R-MMU-8873719",
"R-RNO-6803205",
"R-RNO-8873719"
] | [
"EC:2.5.1.60",
"REACTOME:R-BTA-6803205",
"REACTOME:R-BTA-8873719",
"REACTOME:R-HSA-6803205",
"REACTOME:R-HSA-8873719",
"REACTOME:R-MMU-6803205",
"REACTOME:R-MMU-8873719",
"REACTOME:R-RNO-6803205",
"REACTOME:R-RNO-8873719"
] | 9 | [
"1dce",
"1ltx"
] | 2 | [
"PUB00009404"
] | [
"10745007"
] | [
"Crystal structure of Rab geranylgeranyltransferase at 2.0 A resolution."
] | [
2000
] | 1 | [] | [] | 0 | 0 | null | [
"Eumetazoa",
"bird metagenome"
] | [
732,
1
] | 2 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
5,
4,
5
] | 4 | true | Domain | Rab geranylgeranyltransferase, alpha subunit, insert-domain | Rab geranylgeranyltransferase, alpha subunit, insert-domain | RabGGT_asu_insert-domain | 9 |
IPR009088 | 9,088 | Transcription factor IIA, beta-barrel | TFIIA_b-brl | Homologous_superfamily | 10,294 | false | false | This superfamily represents the β-barrel domain found at the C-terminal of both TOA1 (or α/β) and TOA2 (or gamma) subunits of TFIIA, and their homologues. Transcription factor IIA (TFIIA) is one of several factors that form part of a transcription pre-initiation complex along with RNA polymerase II, the TATA-box-bindin... | [
"GO:0006367",
"GO:0005672"
] | [
"transcription initiation at RNA polymerase II promoter",
"transcription factor TFIIA complex"
] | [
"biological_process",
"cellular_component"
] | 2 | [
"CATHGENE3D",
"SSF"
] | [
"G3DSA:2.30.18.10",
"SSF50784"
] | [
"",
""
] | [
10239,
10275
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-CEL-674695",
"R-CEL-6807505",
"R-CEL-73776",
"R-CEL-73779",
"R-CEL-75953",
"R-CEL-76042",
"R-DDI-674695",
"R-DDI-6807505",
"R-DDI-73776",
"R-DDI-73779",
"R-DDI-75953",
"R-DDI-76042",
"R-DDI-9018519",
"R-DME-674695",
"R-DME-6807505",
"R-DME-73776",
"R-DME-73779",
"R-DME-75953",
... | [
"REACTOME:R-CEL-674695",
"REACTOME:R-CEL-6807505",
"REACTOME:R-CEL-73776",
"REACTOME:R-CEL-73779",
"REACTOME:R-CEL-75953",
"REACTOME:R-CEL-76042",
"REACTOME:R-DDI-674695",
"REACTOME:R-DDI-6807505",
"REACTOME:R-DDI-73776",
"REACTOME:R-DDI-73779",
"REACTOME:R-DDI-75953",
"REACTOME:R-DDI-76042",
... | 58 | [
"1nh2",
"1nvp",
"1rm1",
"1ytf",
"5fmf",
"5fur",
"5fyw",
"5fz5",
"5iy6",
"5iy7",
"5iy8",
"5iy9",
"5iya",
"5iyb",
"5iyc",
"5iyd",
"5m4s",
"5oqj",
"5oqm",
"5sva",
"6gyk",
"6gyl",
"6gym",
"6mzm",
"6o9l",
"7edx",
"7eg7",
"7eg8",
"7eg9",
"7ega",
"7egb",
"7egc"... | 86 | [
"PUB00013248",
"PUB00013320"
] | [
"12818428",
"8610010"
] | [
"TFIIA abrogates the effects of inhibition by HMGB1 but not E1A during the early stages of assembly of the transcriptional preinitiation complex.",
"Crystal structure of a yeast TFIIA/TBP/DNA complex."
] | [
2003,
1996
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
10294
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
20,
3,
6,
7,
10,
9,
3,
8,
13,
2,
2,
24
] | 12 | true | Homologous_superfamily | Transcription factor IIA, beta-barrel | Transcription factor IIA, beta-barrel | TFIIA_b-brl | 6 |
IPR009089 | 9,089 | XRCC4, N-terminal domain superfamily | XRCC4_N_sf | Homologous_superfamily | 1,498 | false | false | XRCC4 is essential for non-homologous DNA end joining (NHDJ) in eukaryotes, which is required for double-strand break repair, and V(D)J recombination in immunoglobulin and T-cell receptor genes. XRCC4 forms a complex with DNA ligase IV, and acts as a regulatory element required for the stability and activity of the lig... | [
"GO:0003677",
"GO:0006302",
"GO:0006310",
"GO:0005634"
] | [
"DNA binding",
"double-strand break repair",
"DNA recombination",
"nucleus"
] | [
"molecular_function",
"biological_process",
"biological_process",
"cellular_component"
] | 4 | [
"SSF"
] | [
"SSF50809"
] | [
""
] | [
1498
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-DDI-5693571",
"R-HSA-164843",
"R-HSA-3108214",
"R-HSA-5693571",
"R-MMU-3108214",
"R-MMU-5693571"
] | [
"REACTOME:R-DDI-5693571",
"REACTOME:R-HSA-164843",
"REACTOME:R-HSA-3108214",
"REACTOME:R-HSA-5693571",
"REACTOME:R-MMU-3108214",
"REACTOME:R-MMU-5693571"
] | 6 | [
"1fu1",
"1ik9",
"3ii6",
"3mud",
"3q4f",
"3rwr",
"3sr2",
"3w03",
"4xa4",
"5chx",
"5cj0",
"5cj4",
"5wj7",
"5wlz",
"6abo",
"7lsy",
"7lt3",
"7m3p",
"7nfc",
"7nfe",
"8bh3",
"8bhv",
"8bhy",
"8bot",
"8eza",
"8ezb",
"9cq3",
"9cq6",
"9cqc",
"9gd7",
"9n81",
"9n82"... | 33 | [
"PUB00013254",
"PUB00013321"
] | [
"11702069",
"11080143"
] | [
"Crystal structure of an Xrcc4-DNA ligase IV complex.",
"Crystal structure of the Xrcc4 DNA repair protein and implications for end joining."
] | [
2001,
2000
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1498
] | 1 | [
"Arabidopsis thaliana",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
4,
2,
1,
5,
7
] | 5 | true | Homologous_superfamily | XRCC4, N-terminal domain superfamily | XRCC4, N-terminal domain superfamily | XRCC4_N_sf | 2 |
IPR009091 | 9,091 | Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II | RCC1/BLIP-II | Homologous_superfamily | 97,829 | false | false | The beta-lactamase-inhibitor protein II (BLIP-II) is a secreted protein produced by the soil bacteria Streptomyces exfoliates SMF19. BLIP-II acts as a potent inhibitor of beta-lactamases such as TEM-1, which is the most widespread resistance enzyme to penicillin antibiotics. BLIP-II binds competitively to TEM-1, but no... | [] | [] | [] | 0 | [
"CATHGENE3D",
"SSF"
] | [
"G3DSA:2.130.10.30",
"SSF50985"
] | [
"",
""
] | [
95502,
97677
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-CEL-1169408",
"R-CEL-936440",
"R-CEL-9615933",
"R-CEL-983168",
"R-CEL-9833482",
"R-CEL-9909505",
"R-DDI-1169408",
"R-DDI-936440",
"R-DDI-983168",
"R-DDI-9909505",
"R-DME-5693565",
"R-DME-8876198",
"R-DME-9013149",
"R-DME-9615933",
"R-DME-983168",
"R-HSA-1169408",
"R-HSA-141444",
... | [
"REACTOME:R-CEL-1169408",
"REACTOME:R-CEL-936440",
"REACTOME:R-CEL-9615933",
"REACTOME:R-CEL-983168",
"REACTOME:R-CEL-9833482",
"REACTOME:R-CEL-9909505",
"REACTOME:R-DDI-1169408",
"REACTOME:R-DDI-936440",
"REACTOME:R-DDI-983168",
"REACTOME:R-DDI-9909505",
"REACTOME:R-DME-5693565",
"REACTOME:R-... | 65 | [
"1a12",
"1i2m",
"1jtd",
"3kci",
"3mvd",
"3of7",
"3qhy",
"3qi0",
"4d4o",
"4d4p",
"4d4q",
"4d9s",
"4dnu",
"4dnv",
"4dnw",
"4gbf",
"4jhn",
"4jhp",
"4l1m",
"4naa",
"4nbm",
"4nc4",
"4o2w",
"4qam",
"4x33",
"5gwn",
"5hq2",
"5t94",
"5tbk",
"5xgs",
"6dd7",
"6xzl"... | 59 | [
"PUB00013255"
] | [
"11573088"
] | [
"Crystal structure and kinetic analysis of beta-lactamase inhibitor protein-II in complex with TEM-1 beta-lactamase."
] | [
2001
] | 1 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"metagenomes"
] | [
63,
9252,
87628,
542,
344
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
166,
14,
166,
27,
140,
71,
6,
104,
80,
4,
4,
267
] | 12 | true | Homologous_superfamily | Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II | Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II | RCC1/BLIP-II | 4 |
IPR009092 | 9,092 | Telokin-like protein, Tlp20, baculovirus | Telokin-like_Tlp20_baculovir | Family | 148 | false | false | The baculovirus, Autographa californica nuclear polyhedrosis virus (AcMNPV), telokin-like protein (Tlp20) lies in a region of the baculoviral genome that is expressed late in the viral replication cycle, however its function is unknown. Tlp20 was discovered using anti-telokin antibodies, telokin being the C-terminal do... | [] | [] | [] | 0 | [
"PFAM",
"CDD"
] | [
"PF06088",
"cd00235"
] | [
"TLP-20",
"TLP-20"
] | [
148,
101
] | 2 | [] | [] | [] | 0 | [
"1tul"
] | 1 | [
"PUB00012259",
"PUB00037786"
] | [
"7517434",
"15299576"
] | [
"Sequence and expression of a baculovirus protein with antigenic similarity to telokin.",
"Molecular structure of a proteolytic fragment of TLP20."
] | [
1994,
1996
] | 2 | [] | [] | 0 | 0 | null | [
"Baculoviridae"
] | [
148
] | 1 | [] | [] | 0 | true | Family | Telokin-like protein, Tlp20, baculovirus | Telokin-like protein, Tlp20, baculovirus | Telokin-like_Tlp20_baculovir | 1 |
IPR009093 | 9,093 | Bacteriophage P22 tailspike, N-terminal | P22_tailspike_N | Domain | 816 | false | false | The tailspike protein of Salmonella bacteriophage P22 is a viral adhesion protein that mediates attachment of the viral protein to host cell-surface lipopolysaccharide. The tailspike protein displays both receptor binding and destroying properties, inactivating the receptor by endoglycosidase activity. The N-terminal, ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF09008"
] | [
"Head_binding"
] | [
816
] | 1 | [] | [] | [] | 0 | [
"1lkt",
"2vky",
"2vnl",
"2xc1",
"5gai",
"6tgf",
"7sg7",
"7ukj",
"8ean",
"8eb7",
"8tvr",
"8u10",
"8u11",
"8u1o",
"9jg6"
] | 15 | [
"PUB00013256",
"PUB00013323"
] | [
"12424253",
"9135118"
] | [
"The tailspike protein of Shigella phage Sf6. A structural homolog of Salmonella phage P22 tailspike protein without sequence similarity in the beta-helix domain.",
"Phage P22 tailspike protein: crystal structure of the head-binding domain at 2.3 A, fully refined structure of the endorhamnosidase at 1.56 A resolu... | [
2003,
1997
] | 2 | [] | [] | 0 | 0 | null | [
"Caudoviricetes",
"Glossina brevipalpis",
"Pseudomonadati"
] | [
48,
1,
767
] | 3 | [] | [] | 0 | true | Domain | Bacteriophage P22 tailspike, N-terminal | Bacteriophage P22 tailspike, N-terminal | P22_tailspike_N | 1 |
IPR009094 | 9,094 | Disulphide bond isomerase DsbC/G, N-terminal domain superfamily | DiS-bond_isomerase_DsbC/G_N_sf | Homologous_superfamily | 10,778 | false | false | This superfamily represents the N-terminal domain of the disulphide bond isomerase DsbC and DsbG. The disulphide bond isomerase (DsbC) is one of five Escherichia coli proteins required for disulphide bond formation, and functions to rearrange incorrect disulphide bonds during oxidative protein folding in the periplasm.... | [
"GO:0042597"
] | [
"periplasmic space"
] | [
"cellular_component"
] | 1 | [
"CATHGENE3D",
"SSF"
] | [
"G3DSA:3.10.450.70",
"SSF54423"
] | [
"",
""
] | [
10680,
10411
] | 2 | [] | [] | [] | 0 | [
"1eej",
"1g0t",
"1jzd",
"1jzo",
"1t3b",
"1tjd",
"1v57",
"1v58",
"2h0g",
"2h0h",
"2h0i",
"2iy2",
"2iyj",
"4i5q",
"4ilf",
"4ml1",
"4ml6",
"4mly",
"4npb",
"5g1k",
"5g1l"
] | 21 | [
"PUB00013257",
"PUB00013324"
] | [
"12234918",
"10700276"
] | [
"The disulfide bond isomerase DsbC is activated by an immunoglobulin-fold thiol oxidoreductase: crystal structure of the DsbC-DsbDalpha complex.",
"Crystal structure of the protein disulfide bond isomerase, DsbC, from Escherichia coli."
] | [
2002,
2000
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Blackberry yellow vein-associated virus",
"Eukaryota",
"Staphylothermus marinus",
"unclassified sequences"
] | [
10613,
2,
21,
1,
141
] | 5 | [
"Escherichia coli (strain K12)"
] | [
2
] | 1 | true | Homologous_superfamily | Disulphide bond isomerase DsbC/G, N-terminal domain superfamily | Disulphide bond isomerase DsbC/G, N-terminal domain superfamily | DiS-bond_isomerase_DsbC/G_N_sf | 2 |
IPR009095 | 9,095 | TRADD, N-terminal | TRADD_N | Domain | 892 | false | false | TRADD is a signalling adaptor protein involved in tumour necrosis factor-receptor I (TNFR1)-associated apoptosis and cell survival. The decision between apoptosis and cell survival involves the interplay between two sequential signalling complexes. The plasma membrane-bound complex I is comprised of TNFR1, TRADD, the k... | [
"GO:0005515",
"GO:0043123"
] | [
"protein binding",
"positive regulation of canonical NF-kappaB signal transduction"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PFAM"
] | [
"PF09034"
] | [
"TRADD_N"
] | [
892
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-3371378",
"R-BTA-5218900",
"R-BTA-5357786",
"R-BTA-5357905",
"R-BTA-5357956",
"R-BTA-5675482",
"R-BTA-69416",
"R-BTA-75893",
"R-DRE-5357905",
"R-DRE-5357956",
"R-HSA-140534",
"R-HSA-3371378",
"R-HSA-5213460",
"R-HSA-5218900",
"R-HSA-5357786",
"R-HSA-5357905",
"R-HSA-5357956",
... | [
"REACTOME:R-BTA-3371378",
"REACTOME:R-BTA-5218900",
"REACTOME:R-BTA-5357786",
"REACTOME:R-BTA-5357905",
"REACTOME:R-BTA-5357956",
"REACTOME:R-BTA-5675482",
"REACTOME:R-BTA-69416",
"REACTOME:R-BTA-75893",
"REACTOME:R-DRE-5357905",
"REACTOME:R-DRE-5357956",
"REACTOME:R-HSA-140534",
"REACTOME:R-H... | 29 | [
"1f2h",
"1f3v"
] | 2 | [
"PUB00013258",
"PUB00013325"
] | [
"10911999",
"12887920"
] | [
"Solution structure of N-TRADD and characterization of the interaction of N-TRADD and C-TRAF2, a key step in the TNFR1 signaling pathway.",
"Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes."
] | [
2000,
2003
] | 2 | [] | [] | 0 | 0 | null | [
"Vertebrata"
] | [
892
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
1,
2,
3
] | 4 | true | Domain | TRADD, N-terminal | TRADD, N-terminal | TRADD_N | 8 |
IPR009097 | 9,097 | Cyclic phosphodiesterase | Cyclic_Pdiesterase | Homologous_superfamily | 44,621 | false | false | This entry represents a β-barrel domain consisting of a duplication of a β/α/β/α/β motif, which is found in plant cyclic phosphodiesterases (CPDases) [ ], as well as catalytic domains from mammalian 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNPase) [ ], and bacterial and archaeal LigT-like 2',3'-cyclic phosphodiest... | [] | [] | [] | 0 | [
"SSF"
] | [
"SSF55144"
] | [
""
] | [
44621
] | 1 | [
"REACTOME"
] | [
"R-HSA-112126"
] | [
"REACTOME:R-HSA-112126"
] | 1 | [
"1fsi",
"1iuh",
"1jh6",
"1jh7",
"1vdx",
"1vgj",
"1woj",
"2d4g",
"2fsq",
"2fyh",
"2i3e",
"2ilx",
"2vfk",
"2vfl",
"2vfy",
"2xmi",
"2y1p",
"2y3x",
"2ydb",
"2ydc",
"2ydd",
"2yoz",
"2yp0",
"2ypc",
"2ype",
"2yph",
"2yq9",
"3j4q",
"3j4r",
"3zbr",
"3zbs",
"3zbz"... | 78 | [
"PUB00013260",
"PUB00036006",
"PUB00075358",
"PUB00083499",
"PUB00083500"
] | [
"11694509",
"17480208",
"25239919",
"26563764",
"23831225"
] | [
"Crystal structures of the semireduced and inhibitor-bound forms of cyclic nucleotide phosphodiesterase from Arabidopsis thaliana.",
"Solution structure of the catalytic domain of RICH protein from goldfish.",
"Structure and mechanism of E. coli RNA 2',3'-cyclic phosphodiesterase.",
"Determinants of ligand bi... | [
2002,
2007,
2014,
2015,
2013
] | 5 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
1384,
28582,
13630,
610,
415
] | 5 | [
"Arabidopsis thaliana",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae... | [
29,
20,
3,
1,
15,
9,
2,
16,
14,
1,
1,
16
] | 12 | true | Homologous_superfamily | Cyclic phosphodiesterase | Cyclic phosphodiesterase | Cyclic_Pdiesterase | 5 |
IPR009099 | 9,099 | Beta-lactamase-inhibitor protein BLIP | Beta-lactamas_inhib | Family | 999 | false | false | The beta-lactamase-inhibitor protein (BLIP) is produced by Streptomyces species. BLIP acts as a potent inhibitor of beta-lactamases such as TEM-1, which is the most widespread resistance enzyme to penicillin antibiotics. BLIP binds competitively to TEM-1 and makes direct contacts with TEM-1 active site residues. BLIP i... | [] | [] | [] | 0 | [
"PFAM",
"PIRSF"
] | [
"PF07467",
"PIRSF009292"
] | [
"BLIP",
"B_lactamas_inhib"
] | [
999,
5
] | 2 | [] | [] | [] | 0 | [
"1jtg",
"1s0w",
"1xxm",
"2b5r",
"2g2u",
"2g2w",
"3c4o",
"3c4p",
"3c7u",
"3c7v",
"3e2k",
"3e2l",
"3gmu",
"3gmv",
"3gmw",
"3gmx",
"3gmy",
"3n4i",
"7s5s",
"9q0a",
"9q0b",
"9q0c"
] | 22 | [
"PUB00013170",
"PUB00013255",
"PUB00161019"
] | [
"8605632",
"11573088",
"36344533"
] | [
"A potent new mode of beta-lactamase inhibition revealed by the 1.7 A X-ray crystallographic structure of the TEM-1-BLIP complex.",
"Crystal structure and kinetic analysis of beta-lactamase inhibitor protein-II in complex with TEM-1 beta-lactamase.",
"An active site loop toggles between conformations to control... | [
1996,
2001,
2022
] | 3 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Bdelloidea",
"Caudoviricetes",
"ecological metagenomes"
] | [
885,
97,
14,
3
] | 4 | [] | [] | 0 | true | Family | Beta-lactamase-inhibitor protein BLIP | Beta-lactamase-inhibitor protein BLIP | Beta-lactamas_inhib | 3 |
IPR009100 | 9,100 | Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain superfamily | AcylCoA_DH/oxidase_NM_dom_sf | Homologous_superfamily | 359,717 | false | false | This superfamily represents both the N-terminal and middle domains found in medium chain acyl-CoA dehydrogenases, as well as in the related peroxisomal acyl-CoA oxidase-II enzymes. Acyl-CoA oxidase (ACO; ) catalyses the first and rate-determining step of the peroxisomal beta-oxidation of fatty acids [ ]. Acyl-CoA dehyd... | [
"GO:0016627"
] | [
"oxidoreductase activity, acting on the CH-CH group of donors"
] | [
"molecular_function"
] | 1 | [
"SSF"
] | [
"SSF56645"
] | [
""
] | [
359717
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-2046106",
"R-BTA-390247",
"R-BTA-70895",
"R-BTA-71064",
"R-BTA-77288",
"R-BTA-77305",
"R-BTA-77346",
"R-BTA-77348",
"R-BTA-9033241",
"R-BTA-9837999",
"R-CEL-193368",
"R-CEL-2046106",
"R-CEL-389887",
"R-CEL-390247",
"R-CEL-71064",
"R-CEL-9033241",
"R-DDI-193368",
"R-DDI-20461... | [
"REACTOME:R-BTA-2046106",
"REACTOME:R-BTA-390247",
"REACTOME:R-BTA-70895",
"REACTOME:R-BTA-71064",
"REACTOME:R-BTA-77288",
"REACTOME:R-BTA-77305",
"REACTOME:R-BTA-77346",
"REACTOME:R-BTA-77348",
"REACTOME:R-BTA-9033241",
"REACTOME:R-BTA-9837999",
"REACTOME:R-CEL-193368",
"REACTOME:R-CEL-204610... | 96 | [
"1buc",
"1egc",
"1egd",
"1ege",
"1is2",
"1ivh",
"1jqi",
"1r2j",
"1rx0",
"1siq",
"1sir",
"1t9g",
"1u8v",
"1udy",
"1ukw",
"1w07",
"1ws9",
"2a1t",
"2c0u",
"2c12",
"2cx9",
"2d29",
"2ddh",
"2dvl",
"2eba",
"2fon",
"2ix5",
"2ix6",
"2jbr",
"2jbs",
"2jbt",
"2jif"... | 213 | [
"PUB00013228",
"PUB00013229",
"PUB00026133"
] | [
"11812788",
"9214289",
"11872165"
] | [
"Crystal structure of rat short chain acyl-CoA dehydrogenase complexed with acetoacetyl-CoA: comparison with other acyl-CoA dehydrogenases.",
"Structure of human isovaleryl-CoA dehydrogenase at 2.6 A resolution: structural basis for substrate specificity,.",
"Three-dimensional structure of the flavoenzyme acyl-... | [
2002,
1997,
2002
] | 3 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Sym plasmid",
"Viruses",
"unclassified sequences"
] | [
4188,
288098,
62453,
3,
11,
4964
] | 6 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
39,
29,
30,
23,
4,
140,
49,
9,
25,
82,
1,
90
] | 12 | true | Homologous_superfamily | Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain superfamily | Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain superfamily | AcylCoA_DH/oxidase_NM_dom_sf | 7 |
IPR009101 | 9,101 | Gurmarin/antifungal peptide | Gurmarin/antifun_pep | Homologous_superfamily | 281 | false | false | Gurmarin is a sweet taste-suppressing polypeptide from the Indian-originated tree Gymnema sylvestre (Gurmar). Gurmarin acts to selectively inhibit the neural response to sweet stimuli in rats. The crystal structure of Gumarin reveals a disulphide-bound fold containing an antiparallel β-hairpin [ ]. The aromatic residue... | [] | [] | [] | 0 | [
"SSF"
] | [
"SSF57048"
] | [
""
] | [
281
] | 1 | [] | [] | [] | 0 | [
"1c4e",
"1dkc",
"1gur",
"1q3j",
"5oll",
"5xbd"
] | 6 | [
"PUB00013261",
"PUB00013262",
"PUB00013263",
"PUB00030103"
] | [
"10491100",
"11697741",
"11551192",
"14661954"
] | [
"High-resolution solution structure of gurmarin, a sweet-taste-suppressing plant polypeptide.",
"Beta-cyclodextrin inhibits the sweet taste suppressing activity of gurmarin by the formation of an inclusion complex with aromatic residues in gurmarin.",
"Solution structure of PAFP-S: a new knottin-type antifungal... | [
1999,
2001,
2001,
2003
] | 4 | [] | [] | 0 | 0 | null | [
"Actinomycetes",
"Eukaryota"
] | [
6,
275
] | 2 | [] | [] | 0 | true | Homologous_superfamily | Gurmarin/antifungal peptide | Gurmarin/antifungal peptide | Gurmarin/antifun_pep | 4 |
IPR009103 | 9,103 | Olfactory marker protein | Olfactory_marker | Family | 492 | false | false | Olfactory marker protein (OMP) is a highly expressed, cytoplasmic protein found in mature olfactory sensory receptor neurons of all vertebrates. OMP is a modulator of the olfactory signal transduction cascade. The crystal structure of OMP reveals a β sandwich consisting of eight strands in two sheets with a jelly-roll ... | [
"GO:0007165",
"GO:0007608"
] | [
"signal transduction",
"sensory perception of smell"
] | [
"biological_process",
"biological_process"
] | 2 | [
"PFAM",
"PANTHER"
] | [
"PF06554",
"PTHR15357"
] | [
"Olfactory_mark",
""
] | [
492,
491
] | 2 | [] | [] | [] | 0 | [
"1f35",
"1job",
"1jod",
"1jyt",
"1zri"
] | 5 | [
"PUB00013265",
"PUB00013266"
] | [
"12054873",
"12054872"
] | [
"Olfactory marker protein (OMP) exhibits a beta-clam fold in solution: implications for target peptide interaction and olfactory signal transduction.",
"The crystal structure of the olfactory marker protein at 2.3 A resolution."
] | [
2002,
2002
] | 2 | [] | [] | 0 | 0 | null | [
"Euteleostomi"
] | [
492
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
1,
3,
3
] | 4 | true | Family | Olfactory marker protein | Olfactory marker protein | Olfactory_marker | 7 |
IPR009104 | 9,104 | Sea anemone actinoporin-like | Anemon_actinoporin-like | Family | 1,485 | false | false | Sea anemones are a rich source of lethal pore-forming peptides and proteins, known collectively as cytolysins or actinoporins. There are several different groups of cytolysins based on their structure and function, and share conserved regions such as a surface-exposed lipid/carbohydrate-binding module involved in toxin... | [
"GO:0015267",
"GO:0006812",
"GO:0046931",
"GO:0051715",
"GO:0046930"
] | [
"channel activity",
"monoatomic cation transport",
"pore complex assembly",
"cytolysis in another organism",
"pore complex"
] | [
"molecular_function",
"biological_process",
"biological_process",
"biological_process",
"cellular_component"
] | 5 | [
"PFAM"
] | [
"PF06369"
] | [
"Anemone_cytotox"
] | [
1485
] | 1 | [] | [] | [] | 0 | [
"1gwy",
"1iaz",
"1kd6",
"1o71",
"1o72",
"1tzq",
"2ks4",
"2l2b",
"2l38",
"3lim",
"3vwi",
"3w9p",
"3zwg",
"3zwj",
"4tsl",
"4tsn",
"4tso",
"4tsp",
"4tsq",
"4tsy",
"4wdc",
"5bpg",
"5gwf",
"6k2g",
"7ekz",
"7pud",
"9eyl",
"9eym",
"9eyn",
"9eyo",
"9eyp",
"9eyq"... | 37 | [
"PUB00013268",
"PUB00015244",
"PUB00015245",
"PUB00015246",
"PUB00076863",
"PUB00099590"
] | [
"11827489",
"11689232",
"14604518",
"14604522",
"19674339",
"31295915"
] | [
"Solution structure of the eukaryotic pore-forming cytolysin equinatoxin II: implications for pore formation.",
"Cytolytic peptide and protein toxins from sea anemones (Anthozoa: Actiniaria).",
"Dissecting the actinoporin pore-forming mechanism.",
"Crystal and electron microscopy structures of sticholysin II ... | [
2002,
2002,
2003,
2003,
2009,
2019
] | 6 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1485
] | 1 | [
"Danio rerio"
] | [
5
] | 1 | true | Family | Sea anemone actinoporin-like | Sea anemone actinoporin-like | Anemon_actinoporin-like | 8 |
IPR009105 | 9,105 | Colicin E3-like ribonuclease domain | Colicin_E3_ribonuclease | Domain | 832 | false | false | Colicins are plasmid-encoded protein antibiotics, or bacteriocins, produced by strains of Escherichia coli that kill closely related bacteria. Colicins are classified according to the cell-surface receptor they bind to, colicin E3 binding to the BtuB receptor involved in vitamin B12 uptake. The lethal action of colicin... | [
"GO:0003723",
"GO:0016788",
"GO:0043022"
] | [
"RNA binding",
"hydrolase activity, acting on ester bonds",
"ribosome binding"
] | [
"molecular_function",
"molecular_function",
"molecular_function"
] | 3 | [
"PFAM"
] | [
"PF09000"
] | [
"Cytotoxic"
] | [
832
] | 1 | [] | [] | [] | 0 | [
"1e44",
"1jch",
"2b5u",
"4udm",
"4v5k"
] | 5 | [
"PUB00011755",
"PUB00013269"
] | [
"11741540",
"10986462"
] | [
"Crystal structure of colicin E3: implications for cell entry and ribosome inactivation.",
"Inhibition of a ribosome-inactivating ribonuclease: the crystal structure of the cytotoxic domain of colicin E3 in complex with its immunity protein."
] | [
2001,
2000
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Opisthokonta",
"ecological metagenomes",
"uncultured Caudovirales phage"
] | [
806,
22,
3,
1
] | 4 | [] | [] | 0 | true | Domain | Colicin E3-like ribonuclease domain | Colicin E3-like ribonuclease domain | Colicin_E3_ribonuclease | 6 |
IPR009106 | 9,106 | CART satiety factor | CART | Family | 1,901 | false | false | The cocaine and amphetamine regulated transcript (CART) is a brain-localised peptide that acts as a satiety factor in appetite regulation. CART was found to inhibit both normal and starvation-induced feeding, and completely blocks the feeding response induced by neuropeptide Y. CART is regulated by leptin in the hypoth... | [
"GO:0007186",
"GO:0008343",
"GO:0009267",
"GO:0032099",
"GO:0043410",
"GO:0005615"
] | [
"G protein-coupled receptor signaling pathway",
"adult feeding behavior",
"cellular response to starvation",
"negative regulation of appetite",
"positive regulation of MAPK cascade",
"extracellular space"
] | [
"biological_process",
"biological_process",
"biological_process",
"biological_process",
"biological_process",
"cellular_component"
] | 6 | [
"PFAM",
"PANTHER"
] | [
"PF06373",
"PTHR16655"
] | [
"CART",
""
] | [
1899,
1859
] | 2 | [] | [] | [] | 0 | [
"1hy9"
] | 1 | [
"PUB00012344",
"PUB00013270",
"PUB00088370"
] | [
"11478874",
"9590691",
"15908120"
] | [
"Solution structure of the satiety factor, CART, reveals new functionality of a well-known fold.",
"Hypothalamic CART is a new anorectic peptide regulated by leptin.",
"Cocaine- and amphetamine-regulated transcript (CART) peptide activates the extracellular signal-regulated kinase (ERK) pathway in AtT20 cells v... | [
2001,
1998,
2005
] | 3 | [] | [] | 0 | 0 | null | [
"Vertebrata"
] | [
1901
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
6,
1,
3,
5
] | 4 | true | Family | CART satiety factor | CART satiety factor | CART | 6 |
IPR009109 | 9,109 | Ran-GTPase activating protein 1, C-terminal | Ran_GTPase_activating_1_C | Domain | 1,963 | false | false | Ran GTPase is a ubiquitous protein required for nuclear transport, spindle assembly, nuclear assembly and mitotic cell cycle regulation. RanGTPase activating protein 1 (RanGAP1) is one of several RanGTPase accessory proteins. During interphase, RanGAP1 is located in the cytoplasm, while during mitosis it becomes associ... | [
"GO:0005096",
"GO:0007165"
] | [
"GTPase activator activity",
"signal transduction"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PFAM"
] | [
"PF07834"
] | [
"RanGAP1_C"
] | [
1963
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-141444",
"R-HSA-165054",
"R-HSA-2467813",
"R-HSA-2500257",
"R-HSA-4615885",
"R-HSA-5663220",
"R-HSA-68877",
"R-HSA-9615933",
"R-HSA-9648025",
"R-HSA-9793242",
"R-MMU-141444",
"R-MMU-2467813",
"R-MMU-2500257",
"R-MMU-4615885",
"R-MMU-5663220",
"R-MMU-68877",
"R-MMU-9615933",
... | [
"REACTOME:R-HSA-141444",
"REACTOME:R-HSA-165054",
"REACTOME:R-HSA-2467813",
"REACTOME:R-HSA-2500257",
"REACTOME:R-HSA-4615885",
"REACTOME:R-HSA-5663220",
"REACTOME:R-HSA-68877",
"REACTOME:R-HSA-9615933",
"REACTOME:R-HSA-9648025",
"REACTOME:R-HSA-9793242",
"REACTOME:R-MMU-141444",
"REACTOME:R-M... | 19 | [
"1kps",
"1z5s",
"2grn",
"2gro",
"2grp",
"2grq",
"2grr",
"2io2",
"2io3",
"2iy0",
"3uin",
"3uio",
"3uip",
"5d2m",
"9b62"
] | 15 | [
"PUB00013273",
"PUB00013274"
] | [
"12852855",
"11853669"
] | [
"The Ran GTPase regulates kinetochore function.",
"Structural basis for E2-mediated SUMO conjugation revealed by a complex between ubiquitin-conjugating enzyme Ubc9 and RanGAP1."
] | [
2003,
2002
] | 2 | [] | [] | 0 | 0 | null | [
"Metazoa"
] | [
1963
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
4,
5,
8,
5
] | 4 | true | Domain | Ran-GTPase activating protein 1, C-terminal | Ran-GTPase activating protein 1, C-terminal | Ran_GTPase_activating_1_C | 1 |
IPR009111 | 9,111 | Quinohemoprotein amine dehydrogenase, alpha subunit, domain 2 | QH-AmDH_asu_dom2 | Domain | 546 | false | false | Quinohemoprotein amine dehydrogenases (QHNDH) ) are enzymes produced in the periplasmic space of certain Gram-negative bacteria, such as Paracoccus denitrificans and Pseudomonas putida, in response to primary amines, including n-butylamine and benzylamine. QHNDH catalyses the oxidative deamination of a wide range of al... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF14930"
] | [
"Qn_am_d_aII"
] | [
546
] | 1 | [] | [] | [] | 0 | [
"1jju",
"1jmx",
"1jmz",
"1pby"
] | 4 | [
"PUB00013277",
"PUB00022422",
"PUB00035735",
"PUB00035736",
"PUB00035737"
] | [
"11704672",
"12925784",
"15234267",
"12974623",
"12427036"
] | [
"Crystal structure of quinohemoprotein amine dehydrogenase from Pseudomonas putida. Identification of a novel quinone cofactor encaged by multiple thioether cross-bridges.",
"Structure of the phenylhydrazine adduct of the quinohemoprotein amine dehydrogenase from Paracoccus denitrificans at 1.7 A resolution.",
... | [
2002,
2003,
2004,
2003,
2002
] | 5 | [] | [] | 0 | 0 | null | [
"Bacteria",
"ecological metagenomes"
] | [
535,
11
] | 2 | [] | [] | 0 | true | Domain | Quinohemoprotein amine dehydrogenase, alpha subunit, domain 2 | Quinohemoprotein amine dehydrogenase, alpha subunit, domain 2 | QH-AmDH_asu_dom2 | 3 |
IPR009112 | 9,112 | GTP cyclohydrolase I, feedback regulatory protein | GTP_CycHdrlase_I_reg | Family | 1,171 | false | false | GTP cyclohydrolase I feedback regulatory protein (GFRP) in mammals helps regulate the biosynthesis of tetrahydrobiopterin through the feedback inhibition of the rate-limiting enzyme GTP cyclohydrolase I (GTPCHI). Tetrahydrobiopterin is the cofactor required for the hydroxylation of aromatic amino acids. The crystal str... | [
"GO:0009890"
] | [
"negative regulation of biosynthetic process"
] | [
"biological_process"
] | 1 | [
"PFAM",
"PANTHER"
] | [
"PF06399",
"PTHR16852"
] | [
"GFRP",
""
] | [
1159,
1070
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-1474151",
"R-HSA-1474151",
"R-MMU-1474151",
"R-RNO-1474151",
"R-XTR-1474151"
] | [
"REACTOME:R-BTA-1474151",
"REACTOME:R-HSA-1474151",
"REACTOME:R-MMU-1474151",
"REACTOME:R-RNO-1474151",
"REACTOME:R-XTR-1474151"
] | 5 | [
"1is7",
"1is8",
"1jg5",
"1wpl",
"6z80",
"6z85",
"7acc",
"7al9",
"7ala",
"7alb",
"7alc",
"7alq"
] | 12 | [
"PUB00012365",
"PUB00013279"
] | [
"11580249",
"11818540"
] | [
"Crystal structure of rat GTP cyclohydrolase I feedback regulatory protein, GFRP.",
"Crystal structure of the stimulatory complex of GTP cyclohydrolase I and its feedback regulatory protein GFRP."
] | [
2001,
2002
] | 2 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
1171
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
2,
4,
2,
3
] | 5 | true | Family | GTP cyclohydrolase I, feedback regulatory protein | GTP cyclohydrolase I, feedback regulatory protein | GTP_CycHdrlase_I_reg | 4 |
IPR009114 | 9,114 | Angiomotin | Angiomotin | Family | 3,720 | false | false | Angiogenesis, the process whereby new blood vessels are formed by a mechanism of sprouting from existing vessels, has recently been the subject of intense research. Angiostatin, a proteolytically generated fragment of plasminogen consisting of the first four kringle domains, is a potent angiogenesis inhibitor. Whilst t... | [] | [] | [] | 0 | [
"PRINTS"
] | [
"PR01807"
] | [
"ANGIOMOTIN"
] | [
3720
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-2028269",
"R-CFA-2028269",
"R-DRE-2028269",
"R-HSA-2028269",
"R-HSA-9762292",
"R-MMU-2028269",
"R-MMU-9762292",
"R-RNO-2028269"
] | [
"REACTOME:R-BTA-2028269",
"REACTOME:R-CFA-2028269",
"REACTOME:R-DRE-2028269",
"REACTOME:R-HSA-2028269",
"REACTOME:R-HSA-9762292",
"REACTOME:R-MMU-2028269",
"REACTOME:R-MMU-9762292",
"REACTOME:R-RNO-2028269"
] | 8 | [] | 0 | [
"PUB00013722",
"PUB00013917",
"PUB00013918"
] | [
"11257132",
"11257124",
"12406577"
] | [
"Hold that line. Angiomotin regulates endothelial cell motility.",
"Angiomotin: an angiostatin binding protein that regulates endothelial cell migration and tube formation.",
"Angiomotin belongs to a novel protein family with conserved coiled-coil and PDZ binding domains."
] | [
2001,
2001,
2002
] | 3 | [] | [] | 0 | 0 | null | [
"Eumetazoa"
] | [
3720
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
8,
9,
12,
13
] | 4 | true | Family | Angiomotin | Angiomotin | Angiomotin | 5 |
IPR009115 | 9,115 | Annexin A8 | ANX8 | Family | 759 | false | false | The annexins (or lipocortins) are a family of proteins that bind to phospholipids in a calcium-dependent manner [ ]. The 12 annexins common to vertebrates are classified in the annexin A family and named as annexins A1-A13 (or ANXA1-ANXA13), leaving A12 unassigned in the official nomenclature. Annexins outside vertebra... | [
"GO:0005509",
"GO:0005544"
] | [
"calcium ion binding",
"calcium-dependent phospholipid binding"
] | [
"molecular_function",
"molecular_function"
] | 2 | [
"PRINTS"
] | [
"PR01808"
] | [
"ANNEXINVIII"
] | [
759
] | 1 | [] | [] | [] | 0 | [
"1w3w",
"1w45"
] | 2 | [
"PUB00001395",
"PUB00013727",
"PUB00013919",
"PUB00013920",
"PUB00013921",
"PUB00015121"
] | [
"1646719",
"9434938",
"2530088",
"12369789",
"9797403",
"15059252"
] | [
"Amino acid sequence analysis of the annexin super-gene family of proteins.",
"The genetic origin of mouse annexin VIII.",
"Vascular anticoagulant beta: a novel human Ca2+/phospholipid binding protein that inhibits coagulation and phospholipase A2 activity. Its molecular cloning, expression and comparison with ... | [
1991,
1998,
1989,
2002,
1998,
2004
] | 6 | [
"IPR001464"
] | [] | 1 | 0 | 1 | [
"Bilateria"
] | [
759
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
10,
2,
4
] | 3 | true | Family | Annexin A8 | Annexin A8 | ANX8 | 6 |
IPR009116 | 9,116 | Annexin A9 | ANX9 | Family | 243 | false | false | The annexins (or lipocortins) are a family of proteins that bind to phospholipids in a calcium-dependent manner [ ]. The 12 annexins common to vertebrates are classified in the annexin A family and named as annexins A1-A13 (or ANXA1-ANXA13), leaving A12 unassigned in the official nomenclature. Annexins outside vertebra... | [
"GO:0005509",
"GO:0005544"
] | [
"calcium ion binding",
"calcium-dependent phospholipid binding"
] | [
"molecular_function",
"molecular_function"
] | 2 | [
"PRINTS"
] | [
"PR01812"
] | [
"ANNEXINXXXI"
] | [
243
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00001395",
"PUB00013921",
"PUB00015121",
"PUB00083277"
] | [
"1646719",
"9797403",
"15059252",
"10899159"
] | [
"Amino acid sequence analysis of the annexin super-gene family of proteins.",
"Identification of the first fungal annexin: analysis of annexin gene duplications and implications for eukaryotic evolution.",
"The annexins.",
"Pemphigus vulgaris antibody identifies pemphaxin. A novel keratinocyte annexin-like mo... | [
1991,
1998,
2004,
2000
] | 4 | [
"IPR001464"
] | [] | 1 | 0 | 1 | [
"Tetrapoda"
] | [
243
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
2,
2
] | 3 | true | Family | Annexin A9 | Annexin A9 | ANX9 | 8 |
IPR009117 | 9,117 | Annexin A14, fungal | ANX14 | Family | 996 | false | false | The annexins (or lipocortins) are a family of proteins that bind to phospholipids in a calcium-dependent manner [ ]. The 12 annexins common to vertebrates are classified in the annexin A family and named as annexins A1-A13 (or ANXA1-ANXA13), leaving A12 unassigned in the official nomenclature. Annexins outside vertebra... | [] | [] | [] | 0 | [
"PRINTS"
] | [
"PR01813"
] | [
"ANNEXINFUNGI"
] | [
996
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00001395",
"PUB00013921",
"PUB00015121"
] | [
"1646719",
"9797403",
"15059252"
] | [
"Amino acid sequence analysis of the annexin super-gene family of proteins.",
"Identification of the first fungal annexin: analysis of annexin gene duplications and implications for eukaryotic evolution.",
"The annexins."
] | [
1991,
1998,
2004
] | 3 | [
"IPR001464"
] | [] | 1 | 0 | 1 | [
"Eukaryota"
] | [
996
] | 1 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)"
] | [
2
] | 1 | true | Family | Annexin A14, fungal | Annexin A14, fungal | ANX14 | 6 |
IPR009118 | 9,118 | Annexin D, plant | AnnexinD_plant | Family | 2,991 | false | false | The annexins (or lipocortins) are a family of proteins that bind to phospholipids in a calcium-dependent manner [ ]. The 12 annexins common to vertebrates are classified in the annexin A family and named as annexins A1-A13 (or ANXA1-ANXA13), leaving A12 unassigned in the official nomenclature. Annexins outside vertebra... | [] | [] | [] | 0 | [
"PRINTS"
] | [
"PR01814"
] | [
"ANNEXINPLANT"
] | [
2991
] | 1 | [] | [] | [] | 0 | [
"1dk5",
"1n00",
"1ycn",
"2q4c",
"3brx"
] | 5 | [
"PUB00001395",
"PUB00013921",
"PUB00015121"
] | [
"1646719",
"9797403",
"15059252"
] | [
"Amino acid sequence analysis of the annexin super-gene family of proteins.",
"Identification of the first fungal annexin: analysis of annexin gene duplications and implications for eukaryotic evolution.",
"The annexins."
] | [
1991,
1998,
2004
] | 3 | [
"IPR001464"
] | [] | 1 | 0 | 1 | [
"Tracheophyta"
] | [
2991
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
17,
13,
24
] | 3 | true | Family | Annexin D, plant | Annexin D, plant | AnnexinD_plant | 5 |
IPR009119 | 9,119 | Beta-secretase BACE | BACE | Family | 2,369 | false | false | One of the major neuropathological hallmarks of Alzheimer's disease (AD) is the progressive formation in the brain of insoluble amyloid plaques and vascular deposits consisting of beta-amyloid protein (beta-APP) [ ]. Production of beta-APP requires proteolytic cleavage of the large type-1 transmembrane (TM) protein amy... | [
"GO:0004190",
"GO:0006508",
"GO:0016020"
] | [
"aspartic-type endopeptidase activity",
"proteolysis",
"membrane"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PRINTS"
] | [
"PR01815"
] | [
"BACEFAMILY"
] | [
2369
] | 1 | [
"EC",
"REACTOME"
] | [
"3.4.23",
"R-HSA-977225"
] | [
"EC:3.4.23",
"REACTOME:R-HSA-977225"
] | 2 | [
"1fkn",
"1m4h",
"1sgz",
"1tqf",
"1w50",
"1w51",
"1xn2",
"1xn3",
"1xs7",
"1ym2",
"1ym4",
"2b8l",
"2b8v",
"2ewy",
"2f3e",
"2f3f",
"2fdp",
"2g94",
"2hiz",
"2hm1",
"2iqg",
"2irz",
"2is0",
"2ntr",
"2oah",
"2of0",
"2ohk",
"2ohl",
"2ohm",
"2ohn",
"2ohp",
"2ohq"... | 447 | [
"PUB00013732",
"PUB00013925",
"PUB00013926",
"PUB00013927",
"PUB00013928",
"PUB00013929"
] | [
"2881207",
"6375662",
"10531052",
"10656250",
"10591213",
"12391600"
] | [
"The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor.",
"Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein.",
"Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane asparti... | [
1987,
1984,
1999,
1999,
1999,
2002
] | 6 | [
"IPR001461"
] | [
"IPR009120",
"IPR009121"
] | 1 | 2 | 0 | [
"Metazoa"
] | [
2369
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
13,
9,
6
] | 4 | true | Family | Beta-secretase BACE | Beta-secretase BACE | BACE | 1 |
IPR009120 | 9,120 | Beta-secretase BACE1 | BACE1 | Family | 1,491 | false | false | The beta-site APP cleaving enzyme-1 (BACE1), also known as Aspartyl protease 2 and memapsin-2, mediates one of the two proteolytic cleavages of beta-amyloid precursor protein (APP) to yield the amyloid β-peptide (Abeta), a key pathogenic agent in Alzheimer's disease (AD) [ ]. Axonal and Schwann cell BACE1 is also requi... | [
"GO:0004190",
"GO:0006508",
"GO:0016020"
] | [
"aspartic-type endopeptidase activity",
"proteolysis",
"membrane"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PRINTS"
] | [
"PR01816"
] | [
"BACE1"
] | [
1491
] | 1 | [
"EC",
"REACTOME"
] | [
"3.4.23.46",
"R-HSA-977225"
] | [
"EC:3.4.23.46",
"REACTOME:R-HSA-977225"
] | 2 | [
"1fkn",
"1m4h",
"1sgz",
"1tqf",
"1w50",
"1w51",
"1xn2",
"1xn3",
"1xs7",
"1ym2",
"1ym4",
"2b8l",
"2b8v",
"2f3e",
"2f3f",
"2fdp",
"2g94",
"2hiz",
"2hm1",
"2iqg",
"2irz",
"2is0",
"2ntr",
"2oah",
"2of0",
"2ohk",
"2ohl",
"2ohm",
"2ohn",
"2ohp",
"2ohq",
"2ohr"... | 428 | [
"PUB00074551",
"PUB00074553",
"PUB00074554"
] | [
"20354142",
"25740511",
"25621019"
] | [
"Proteomic identification of sorting nexin 6 as a negative regulator of BACE1-mediated APP processing.",
"Axonal and Schwann Cell BACE1 Is Equally Required for Remyelination of Peripheral Nerves.",
"BACE1 inhibitor drugs in clinical trials for Alzheimer's disease."
] | [
2010,
2015,
2014
] | 3 | [
"IPR009119"
] | [] | 1 | 0 | 1 | [
"Eumetazoa"
] | [
1491
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
12,
8,
4
] | 4 | true | Family | Beta-secretase BACE1 | Beta-secretase BACE1 | BACE1 | 2 |
IPR009122 | 9,122 | Desmosomal cadherin | Desmosomal_cadherin | Family | 3,825 | false | false | Cadherins, first discovered in mouse teratocarcinoma cells [ ], are structurally and functionally similar molecules [ ] that take part in selective calcium-dependent adhesion interactions between cell surfaces [ ]. There are a number of different isoforms distributed in a tissue-specific manner in a wide variety of org... | [
"GO:0005509",
"GO:0016020"
] | [
"calcium ion binding",
"membrane"
] | [
"molecular_function",
"cellular_component"
] | 2 | [
"PRINTS",
"PRINTS"
] | [
"PR01818",
"PR01819"
] | [
"DESMOCADHERN",
"DESMOGLEIN"
] | [
3753,
1783
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-CFA-351906",
"R-CFA-6805567",
"R-CFA-6809371",
"R-DRE-351906",
"R-DRE-6798695",
"R-DRE-6805567",
"R-DRE-6809371",
"R-DRE-9013404",
"R-DRE-9013408",
"R-DRE-9696264",
"R-DRE-9696270",
"R-HSA-351906",
"R-HSA-6798695",
"R-HSA-6805567",
"R-HSA-6809371",
"R-HSA-9013404",
"R-HSA-9013408"... | [
"REACTOME:R-CFA-351906",
"REACTOME:R-CFA-6805567",
"REACTOME:R-CFA-6809371",
"REACTOME:R-DRE-351906",
"REACTOME:R-DRE-6798695",
"REACTOME:R-DRE-6805567",
"REACTOME:R-DRE-6809371",
"REACTOME:R-DRE-9013404",
"REACTOME:R-DRE-9013408",
"REACTOME:R-DRE-9696264",
"REACTOME:R-DRE-9696270",
"REACTOME:... | 37 | [
"8qjx",
"8qjy",
"8qk3"
] | 3 | [
"PUB00001100",
"PUB00001188",
"PUB00003452",
"PUB00013742",
"PUB00013934",
"PUB00013935",
"PUB00013936",
"PUB00013937"
] | [
"1893866",
"2390969",
"2384753",
"11509257",
"12126234",
"11171365",
"9443898",
"12582396"
] | [
"Expression of a novel cadherin (EP-cadherin) in unfertilized eggs and early Xenopus embryos.",
"Identification and cloning of two species of cadherins in bovine endothelial cells.",
"N-cadherin gene maps to human chromosome 18 and is not linked to the E-cadherin gene.",
"Cadherin function: breaking the barri... | [
1991,
1990,
1990,
2001,
2002,
2001,
1998,
2003
] | 8 | [] | [] | 0 | 0 | null | [
"Gnathostomata"
] | [
3825
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
8,
30,
18,
14
] | 4 | true | Family | Desmosomal cadherin | Desmosomal cadherin | Desmosomal_cadherin | 9 |
IPR009125 | 9,125 | ATP synthase membrane subunit K | ATPMK | Family | 1,337 | false | false | ATP synthase membrane subunit K (ATPMK, also known as DAPIT) is a subunit of mitochondrial ATP synthase that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain [ , ]. In humans ATP5MD (also known as DAPIT) is a minor... | [] | [] | [] | 0 | [
"PFAM",
"PRINTS",
"PANTHER"
] | [
"PF14960",
"PR01821",
"PTHR34038"
] | [
"ATP_synth_reg",
"DAPIT",
""
] | [
1335,
1079,
1044
] | 3 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-163210",
"R-BTA-8949613",
"R-HSA-163210",
"R-HSA-8949613",
"R-MMU-163210",
"R-MMU-8949613",
"R-RNO-163210",
"R-RNO-8949613"
] | [
"REACTOME:R-BTA-163210",
"REACTOME:R-BTA-8949613",
"REACTOME:R-HSA-163210",
"REACTOME:R-HSA-8949613",
"REACTOME:R-MMU-163210",
"REACTOME:R-MMU-8949613",
"REACTOME:R-RNO-163210",
"REACTOME:R-RNO-8949613"
] | 8 | [
"6j54",
"6j5a",
"6j5i",
"6j5j",
"6j5k",
"6tt7",
"6za9",
"6zbb",
"6ziq",
"6zit",
"6zmr",
"6zna",
"6zpo",
"6zqm",
"6zqn",
"7ajb",
"7ajc",
"7ajd",
"7aje",
"7ajf",
"7ajg",
"7ajh",
"7aji",
"7ajj",
"9bxu",
"9byk"
] | 26 | [
"PUB00089719",
"PUB00089720",
"PUB00094719"
] | [
"21345788",
"26161955",
"29917077"
] | [
"Knockdown of DAPIT (diabetes-associated protein in insulin-sensitive tissue) results in loss of ATP synthase in mitochondria.",
"DAPIT Over-Expression Modulates Glucose Metabolism and Cell Behaviour in HEK293T Cells.",
"USMG5 Ashkenazi Jewish founder mutation impairs mitochondrial complex V dimerization and AT... | [
2011,
2015,
2018
] | 3 | [] | [] | 0 | 0 | null | [
"Opisthokonta"
] | [
1337
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
5,
1,
1,
4
] | 5 | true | Family | ATP synthase membrane subunit K | ATP synthase membrane subunit K | ATPMK | 3 |
IPR009126 | 9,126 | Cholecystokinin receptor | Cholcskin_rcpt | Family | 2,633 | false | false | G protein-coupled receptors (GPCRs) constitute a vast protein family that encompasses a wide range of functions, including various autocrine, paracrine and endocrine processes. They show considerable diversity at the sequence level, on the basis of which they can be separated into distinct groups [ ]. The term clan can... | [
"GO:0007186",
"GO:0016020"
] | [
"G protein-coupled receptor signaling pathway",
"membrane"
] | [
"biological_process",
"cellular_component"
] | 2 | [
"PRINTS"
] | [
"PR01822"
] | [
"CCYSTOKININR"
] | [
2633
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-CFA-375276",
"R-CFA-416476",
"R-CFA-881907",
"R-HSA-375276",
"R-HSA-416476",
"R-HSA-881907",
"R-MMU-375276",
"R-MMU-416476",
"R-MMU-881907",
"R-RNO-375276",
"R-RNO-416476",
"R-RNO-881907"
] | [
"REACTOME:R-CFA-375276",
"REACTOME:R-CFA-416476",
"REACTOME:R-CFA-881907",
"REACTOME:R-HSA-375276",
"REACTOME:R-HSA-416476",
"REACTOME:R-HSA-881907",
"REACTOME:R-MMU-375276",
"REACTOME:R-MMU-416476",
"REACTOME:R-MMU-881907",
"REACTOME:R-RNO-375276",
"REACTOME:R-RNO-416476",
"REACTOME:R-RNO-881... | 12 | [
"1hzn",
"7ezh",
"7ezk",
"7ezm",
"7f8v",
"7f8w",
"7mbx",
"7mby",
"7xou",
"7xov",
"7xow",
"8ia7",
"9bkj",
"9bkk"
] | 14 | [
"PUB00000131",
"PUB00002477",
"PUB00004960",
"PUB00004961",
"PUB00053635",
"PUB00063577",
"PUB00063578",
"PUB00063579",
"PUB00063580",
"PUB00063816"
] | [
"2111655",
"2830256",
"8386361",
"8170923",
"12679517",
"8081729",
"15914470",
"18948278",
"16753280",
"23020293"
] | [
"G proteins in signal transduction.",
"G protein involvement in receptor-effector coupling.",
"Design of a discriminating fingerprint for G-protein-coupled receptors.",
"Fingerprinting G-protein-coupled receptors.",
"The G protein-coupled receptor repertoires of human and mouse.",
"GCRDb: a G-protein-coup... | [
1990,
1988,
1993,
1994,
2003,
1994,
2005,
2009,
2006,
2013
] | 10 | [
"IPR000276"
] | [
"IPR000314",
"IPR000596"
] | 1 | 2 | 0 | [
"Bilateria",
"bird metagenome"
] | [
2632,
1
] | 2 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
6,
6,
5,
4,
7,
8
] | 6 | true | Family | Cholecystokinin receptor | Cholecystokinin receptor | Cholcskin_rcpt | 2 |
IPR009132 | 9,132 | Trace amine associated receptor family | TAAR_fam | Family | 3,340 | false | false | Trace amines, such as tyramine, beta-phenylethylamine, tryptamine and octopamine are biogenic amines present in trace levels in mammalian nervous systems [ ]. Although some "trace amines" have clearly defined roles as neurotransmitters in invertebrates, the extent to which they function as true neurotransmitters in ver... | [
"GO:0001594",
"GO:0007186",
"GO:0016020"
] | [
"trace-amine receptor activity",
"G protein-coupled receptor signaling pathway",
"membrane"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PRINTS"
] | [
"PR01830"
] | [
"TRACEAMINER"
] | [
3340
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-DRE-375280",
"R-HSA-375280",
"R-HSA-418555",
"R-MMU-375280",
"R-MMU-418555",
"R-RNO-375280"
] | [
"REACTOME:R-DRE-375280",
"REACTOME:R-HSA-375280",
"REACTOME:R-HSA-418555",
"REACTOME:R-MMU-375280",
"REACTOME:R-MMU-418555",
"REACTOME:R-RNO-375280"
] | 6 | [
"8itf",
"8iw1",
"8iw4",
"8iw7",
"8iw9",
"8iwe",
"8iwm",
"8jlj",
"8jlk",
"8jln",
"8jlo",
"8jlp",
"8jlq",
"8jlr",
"8jso",
"8pm2",
"8uhb",
"8w87",
"8w88",
"8w89",
"8w8a",
"8wc3",
"8wc4",
"8wc5",
"8wc6",
"8wc7",
"8wc8",
"8wc9",
"8wca",
"8wcb",
"8wcc",
"8zsj"... | 36 | [
"PUB00019026",
"PUB00068195",
"PUB00068196",
"PUB00068197",
"PUB00068198",
"PUB00068199",
"PUB00068200",
"PUB00068201",
"PUB00068202",
"PUB00068203",
"PUB00068204",
"PUB00068205",
"PUB00068206"
] | [
"11459929",
"17088868",
"15718104",
"19325074",
"11723224",
"15860375",
"16451074",
"19237578",
"15891052",
"14559210",
"15146179",
"16878137",
"19686131"
] | [
"Trace amines: identification of a family of mammalian G protein-coupled receptors.",
"Trace amine-associated receptors and their ligands.",
"Trace amine-associated receptors form structurally and functionally distinct subfamilies of novel G protein-coupled receptors.",
"International Union of Pharmacology. L... | [
2001,
2006,
2005,
2009,
2001,
2005,
2006,
2009,
2005,
2003,
2004,
2006,
2009
] | 13 | [
"IPR000276"
] | [
"IPR009133"
] | 1 | 1 | 0 | [
"Gnathostomata"
] | [
3340
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
39,
7,
22,
43
] | 4 | true | Family | Trace amine associated receptor family | Trace amine associated receptor family | TAAR_fam | 1 |
IPR009133 | 9,133 | Trace amine associated receptor 1 | TAAR1 | Family | 807 | false | false | Trace amines, such as tyramine, beta-phenylethylamine, tryptamine and octopamine are biogenic amines present in trace levels in mammalian nervous systems [ ]. Although some "trace amines" have clearly defined roles as neurotransmitters in invertebrates, the extent to which they function as true neurotransmitters in ver... | [
"GO:0001594",
"GO:0007186",
"GO:0016020"
] | [
"trace-amine receptor activity",
"G protein-coupled receptor signaling pathway",
"membrane"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PRINTS"
] | [
"PR01831"
] | [
"TRACEAMINE1R"
] | [
807
] | 1 | [
"IUPHAR",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"364",
"R-HSA-375280",
"R-HSA-418555",
"R-MMU-375280",
"R-MMU-418555",
"R-RNO-375280"
] | [
"IUPHAR:364",
"REACTOME:R-HSA-375280",
"REACTOME:R-HSA-418555",
"REACTOME:R-MMU-375280",
"REACTOME:R-MMU-418555",
"REACTOME:R-RNO-375280"
] | 6 | [
"8jlj",
"8jlk",
"8jln",
"8jlo",
"8jlp",
"8jlq",
"8jlr",
"8jso",
"8uhb",
"8w87",
"8w88",
"8w89",
"8w8a",
"8wc3",
"8wc4",
"8wc5",
"8wc6",
"8wc7",
"8wc8",
"8wc9",
"8wca",
"8wcb",
"8wcc",
"8zsj",
"8zsp",
"8zss",
"8zsv",
"9jkq"
] | 28 | [
"PUB00019026",
"PUB00068195",
"PUB00068196",
"PUB00068197",
"PUB00068198",
"PUB00068199",
"PUB00068200",
"PUB00068201",
"PUB00068202",
"PUB00068203",
"PUB00068204",
"PUB00068205",
"PUB00068206",
"PUB00068232"
] | [
"11459929",
"17088868",
"15718104",
"19325074",
"11723224",
"15860375",
"16451074",
"19237578",
"15891052",
"14559210",
"15146179",
"16878137",
"19686131",
"22038157"
] | [
"Trace amines: identification of a family of mammalian G protein-coupled receptors.",
"Trace amine-associated receptors and their ligands.",
"Trace amine-associated receptors form structurally and functionally distinct subfamilies of novel G protein-coupled receptors.",
"International Union of Pharmacology. L... | [
2001,
2006,
2005,
2009,
2001,
2005,
2006,
2009,
2005,
2003,
2004,
2006,
2009,
2012
] | 14 | [
"IPR009132"
] | [] | 1 | 0 | 1 | [
"Gnathostomata"
] | [
807
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
1,
1,
6
] | 4 | true | Family | Trace amine associated receptor 1 | Trace amine associated receptor 1 | TAAR1 | 3 |
IPR009135 | 9,135 | Vascular endothelial growth factor receptor 1 (VEGFR1) | VEGFR1_rcpt | Family | 1,339 | false | false | Vascular endothelial growth factor (VEGF) is a potent and specific endothelial cell mitogen that regulates blood and lymphatic vessel development and homeostasis [ , ]. EGFs are predominantly produced by endothelial, hematopoietic, and stromal cells in response to hypoxia and upon stimulation by growth factors such as ... | [
"GO:0005021",
"GO:0005524",
"GO:0006468",
"GO:0048010",
"GO:0005886"
] | [
"vascular endothelial growth factor receptor activity",
"ATP binding",
"protein phosphorylation",
"vascular endothelial growth factor receptor signaling pathway",
"plasma membrane"
] | [
"molecular_function",
"molecular_function",
"biological_process",
"biological_process",
"cellular_component"
] | 5 | [
"PRINTS"
] | [
"PR01833"
] | [
"VEGFRECEPTR1"
] | [
1339
] | 1 | [
"EC",
"IUPHAR",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"2.7.10.1",
"335",
"R-HSA-194306",
"R-HSA-195399",
"R-MMU-194306",
"R-MMU-195399",
"R-RNO-194306",
"R-RNO-195399"
] | [
"EC:2.7.10.1",
"IUPHAR:335",
"REACTOME:R-HSA-194306",
"REACTOME:R-HSA-195399",
"REACTOME:R-MMU-194306",
"REACTOME:R-MMU-195399",
"REACTOME:R-RNO-194306",
"REACTOME:R-RNO-195399"
] | 8 | [
"1qsv",
"1qsz",
"1qty",
"1rv6",
"2xac",
"5t89"
] | 6 | [
"PUB00013873",
"PUB00013875",
"PUB00013877",
"PUB00052418"
] | [
"2478587",
"7526212",
"7538139",
"19290920"
] | [
"Tumor vascular permeability factor stimulates endothelial cell growth and angiogenesis.",
"Vascular endothelial growth factor in ocular fluid of patients with diabetic retinopathy and other retinal disorders.",
"Endothelial receptor tyrosine kinases involved in angiogenesis.",
"The structure, regulation, and... | [
1989,
1994,
1995,
2009
] | 4 | [] | [] | 0 | 0 | null | [
"Gnathostomata"
] | [
1339
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
4,
6,
5
] | 4 | true | Family | Vascular endothelial growth factor receptor 1 (VEGFR1) | Vascular endothelial growth factor receptor 1 (VEGFR1) | VEGFR1_rcpt | 5 |
IPR009136 | 9,136 | Vascular endothelial growth factor receptor 2 (VEGFR2) | VEGFR2_rcpt | Family | 1,203 | false | false | Vascular endothelial growth factor (VEGF) is a potent and specific endothelial cell mitogen that regulates blood and lymphatic vessel development and homeostasis [ , ]. EGFs are predominantly produced by endothelial, hematopoietic, and stromal cells in response to hypoxia and upon stimulation by growth factors such as ... | [
"GO:0005021",
"GO:0005524",
"GO:0019838",
"GO:0006468",
"GO:0048010",
"GO:0016020"
] | [
"vascular endothelial growth factor receptor activity",
"ATP binding",
"growth factor binding",
"protein phosphorylation",
"vascular endothelial growth factor receptor signaling pathway",
"membrane"
] | [
"molecular_function",
"molecular_function",
"molecular_function",
"biological_process",
"biological_process",
"cellular_component"
] | 6 | [
"PRINTS"
] | [
"PR01834"
] | [
"VEGFRECEPTR2"
] | [
1203
] | 1 | [
"EC",
"IUPHAR",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"2.7.10.1",
"336",
"R-HSA-194306",
"R-HSA-195399",
"R-HSA-216083",
"R-HSA-4420097",
"R-HSA-5218921",
"R-HSA-9673768",
"R-HSA-9856530",
"R-MMU-194306",
"R-MMU-195399",
"R-MMU-4420097",
"R-MMU-5218921",
"R-RNO-194306",
"R-RNO-195399",
"R-RNO-4420097",
"R-RNO-5218921"
] | [
"EC:2.7.10.1",
"IUPHAR:336",
"REACTOME:R-HSA-194306",
"REACTOME:R-HSA-195399",
"REACTOME:R-HSA-216083",
"REACTOME:R-HSA-4420097",
"REACTOME:R-HSA-5218921",
"REACTOME:R-HSA-9673768",
"REACTOME:R-HSA-9856530",
"REACTOME:R-MMU-194306",
"REACTOME:R-MMU-195399",
"REACTOME:R-MMU-4420097",
"REACTOM... | 17 | [
"2x1w",
"2x1x",
"3v2a",
"3v6b"
] | 4 | [
"PUB00013873",
"PUB00013875",
"PUB00013877",
"PUB00013878",
"PUB00052418"
] | [
"2478587",
"7526212",
"7538139",
"7929439",
"19290920"
] | [
"Tumor vascular permeability factor stimulates endothelial cell growth and angiogenesis.",
"Vascular endothelial growth factor in ocular fluid of patients with diabetic retinopathy and other retinal disorders.",
"Endothelial receptor tyrosine kinases involved in angiogenesis.",
"Different signal transduction ... | [
1989,
1994,
1995,
1994,
2009
] | 5 | [] | [] | 0 | 0 | null | [
"Gnathostomata"
] | [
1203
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
3,
4
] | 3 | true | Family | Vascular endothelial growth factor receptor 2 (VEGFR2) | Vascular endothelial growth factor receptor 2 (VEGFR2) | VEGFR2_rcpt | 2 |
IPR009138 | 9,138 | Neural cell adhesion | Neural_cell_adh | Family | 6,523 | false | false | Neural cell adhesion molecules (NCAM) are cell surface glycoproteins that share structural motifs related to immunoglobulin (Ig) and fibronectin type III (FNIII) domains. Expressed in neurons, glial cells and skeletal muscle, NCAM binds both homophilically and heterophilically, mediating processes such as neural cell g... | [
"GO:0007155",
"GO:0016020"
] | [
"cell adhesion",
"membrane"
] | [
"biological_process",
"cellular_component"
] | 2 | [
"PRINTS"
] | [
"PR01838"
] | [
"NCAMFAMILY"
] | [
6523
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-3000178",
"R-HSA-375165",
"R-HSA-419037",
"R-HSA-445144",
"R-HSA-5673001",
"R-HSA-877300",
"R-MMU-375165",
"R-MMU-419037",
"R-MMU-445144",
"R-MMU-5673001",
"R-RNO-375165",
"R-RNO-419037",
"R-RNO-445144",
"R-RNO-5673001"
] | [
"REACTOME:R-HSA-3000178",
"REACTOME:R-HSA-375165",
"REACTOME:R-HSA-419037",
"REACTOME:R-HSA-445144",
"REACTOME:R-HSA-5673001",
"REACTOME:R-HSA-877300",
"REACTOME:R-MMU-375165",
"REACTOME:R-MMU-419037",
"REACTOME:R-MMU-445144",
"REACTOME:R-MMU-5673001",
"REACTOME:R-RNO-375165",
"REACTOME:R-RNO-... | 14 | [
"1epf",
"1qz1",
"2ncm",
"2vaj",
"2wim",
"2xy2",
"3laf",
"5z5k",
"6iaa"
] | 9 | [
"PUB00013884",
"PUB00013885",
"PUB00013886",
"PUB00013888"
] | [
"9442880",
"8806073",
"3891761",
"6577452"
] | [
"Neural cell adhesion molecules of the immunoglobulin superfamily: role in axon growth and guidance.",
"Elucidation of the molecular actions of NCAM and structurally related cell adhesion molecules.",
"N-CAM at the vertebrate neuromuscular junction.",
"Kinetics of homophilic binding by embryonic and adult for... | [
1997,
1996,
1985,
1983
] | 4 | [] | [] | 0 | 0 | null | [
"Metazoa"
] | [
6523
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
83,
6,
12,
8,
19
] | 6 | true | Family | Neural cell adhesion | Neural cell adhesion | Neural_cell_adh | 7 |
IPR009139 | 9,139 | Wnt-1 protein | Wnt1 | Family | 800 | false | false | Wnt proteins constitute a large family of secreted molecules that are involved in intercellular signalling during development. The name derives from the first 2 members of the family to be discovered: int-1 (mouse) and wingless (Drosophila) [ ]. It is now recognised that Wnt signalling controls many cell fate decisions... | [
"GO:0005102",
"GO:0007275",
"GO:0016055",
"GO:0005576"
] | [
"signaling receptor binding",
"multicellular organism development",
"Wnt signaling pathway",
"extracellular region"
] | [
"molecular_function",
"biological_process",
"biological_process",
"cellular_component"
] | 4 | [
"PRINTS"
] | [
"PR01841"
] | [
"WNT1PROTEIN"
] | [
800
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-DRE-3238698",
"R-DRE-4086400",
"R-DRE-4641262",
"R-HSA-201681",
"R-HSA-3238698",
"R-HSA-373080",
"R-HSA-381340",
"R-HSA-4086400",
"R-HSA-4641262",
"R-MMU-201681",
"R-MMU-3238698",
"R-MMU-4086400",
"R-MMU-4641262"
] | [
"REACTOME:R-DRE-3238698",
"REACTOME:R-DRE-4086400",
"REACTOME:R-DRE-4641262",
"REACTOME:R-HSA-201681",
"REACTOME:R-HSA-3238698",
"REACTOME:R-HSA-373080",
"REACTOME:R-HSA-381340",
"REACTOME:R-HSA-4086400",
"REACTOME:R-HSA-4641262",
"REACTOME:R-MMU-201681",
"REACTOME:R-MMU-3238698",
"REACTOME:R-... | 13 | [] | 0 | [
"PUB00011232",
"PUB00011233",
"PUB00011234",
"PUB00011562",
"PUB00013890",
"PUB00055528"
] | [
"9891778",
"10967351",
"10733430",
"9192851",
"10508601",
"21536746"
] | [
"Mechanisms of Wnt signaling in development.",
"Wnt signaling function in Alzheimer's disease.",
"Wnt signaling in oncogenesis and embryogenesis--a look outside the nucleus.",
"Human dishevelled genes constitute a DHR-containing multigene family.",
"Wnt signalling shows its versatility.",
"Generating a Wn... | [
1998,
2000,
2000,
1997,
1999,
2011
] | 6 | [
"IPR005817"
] | [] | 1 | 0 | 1 | [
"Bilateria"
] | [
800
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
4,
1,
2,
2
] | 4 | true | Family | Wnt-1 protein | Wnt-1 protein | Wnt1 | 9 |
IPR009140 | 9,140 | Wnt-2 protein | Wnt2 | Family | 1,858 | false | false | Wnt proteins constitute a large family of secreted molecules that are involved in intercellular signalling during development. The name derives from the first 2 members of the family to be discovered: int-1 (mouse) and wingless (Drosophila) [ ]. It is now recognised that Wnt signalling controls many cell fate decisions... | [
"GO:0005102",
"GO:0007275",
"GO:0016055",
"GO:0005576"
] | [
"signaling receptor binding",
"multicellular organism development",
"Wnt signaling pathway",
"extracellular region"
] | [
"molecular_function",
"biological_process",
"biological_process",
"cellular_component"
] | 4 | [
"PRINTS"
] | [
"PR01842"
] | [
"WNT2PROTEIN"
] | [
1858
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-3238698",
"R-DRE-3238698",
"R-HSA-3238698",
"R-HSA-373080",
"R-MMU-3238698"
] | [
"REACTOME:R-BTA-3238698",
"REACTOME:R-DRE-3238698",
"REACTOME:R-HSA-3238698",
"REACTOME:R-HSA-373080",
"REACTOME:R-MMU-3238698"
] | 5 | [] | 0 | [
"PUB00011232",
"PUB00011233",
"PUB00011234",
"PUB00011562",
"PUB00013890",
"PUB00013891",
"PUB00055528"
] | [
"9891778",
"10967351",
"10733430",
"9192851",
"10508601",
"2971536",
"21536746"
] | [
"Mechanisms of Wnt signaling in development.",
"Wnt signaling function in Alzheimer's disease.",
"Wnt signaling in oncogenesis and embryogenesis--a look outside the nucleus.",
"Human dishevelled genes constitute a DHR-containing multigene family.",
"Wnt signalling shows its versatility.",
"Isolation of a ... | [
1998,
2000,
2000,
1997,
1999,
1988,
2011
] | 7 | [
"IPR005817"
] | [] | 1 | 0 | 1 | [
"Eumetazoa"
] | [
1858
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
7,
5,
7
] | 4 | true | Family | Wnt-2 protein | Wnt-2 protein | Wnt2 | 4 |
IPR009141 | 9,141 | Wnt-3 protein | Wnt3 | Family | 1,874 | false | false | This entry represents the family of proto-oncogene Wnt-3 and related proteins. Wnt-3, also called proto-oncogene Int-4, functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family. The Wnt-3 gene was first identified in mouse in 1987, where it was found to ... | [
"GO:0005102",
"GO:0007275",
"GO:0016055",
"GO:0005576"
] | [
"signaling receptor binding",
"multicellular organism development",
"Wnt signaling pathway",
"extracellular region"
] | [
"molecular_function",
"biological_process",
"biological_process",
"cellular_component"
] | 4 | [
"PRINTS",
"CDD"
] | [
"PR01843",
"cd19335"
] | [
"WNT3PROTEIN",
"Wnt_Wnt3_Wnt3a"
] | [
1843,
1705
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-GGA-201681",
"R-GGA-3238698",
"R-GGA-4641262",
"R-GGA-4641263",
"R-GGA-9856649",
"R-HSA-201681",
"R-HSA-3238698",
"R-HSA-373080",
"R-HSA-3772470",
"R-HSA-4641262",
"R-HSA-4641263",
"R-HSA-5340588",
"R-HSA-9793380",
"R-HSA-9832991",
"R-HSA-9834899",
"R-HSA-9856649",
"R-MMU-201681",... | [
"REACTOME:R-GGA-201681",
"REACTOME:R-GGA-3238698",
"REACTOME:R-GGA-4641262",
"REACTOME:R-GGA-4641263",
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"REACTOME:R-HSA-3238698",
"REACTOME:R-HSA-373080",
"REACTOME:R-HSA-3772470",
"REACTOME:R-HSA-4641262",
"REACTOME:R-HSA-4641263",
"REACTOME:R... | 21 | [
"6ahy",
"7drt",
"8tzr"
] | 3 | [
"PUB00011232",
"PUB00011233",
"PUB00011234",
"PUB00011562",
"PUB00013890",
"PUB00013892",
"PUB00013893",
"PUB00055528",
"PUB00103825",
"PUB00103826"
] | [
"9891778",
"10967351",
"10733430",
"9192851",
"10508601",
"2162045",
"8244403",
"21536746",
"20722074",
"31036956"
] | [
"Mechanisms of Wnt signaling in development.",
"Wnt signaling function in Alzheimer's disease.",
"Wnt signaling in oncogenesis and embryogenesis--a look outside the nucleus.",
"Human dishevelled genes constitute a DHR-containing multigene family.",
"Wnt signalling shows its versatility.",
"Wnt-3, a gene a... | [
1998,
2000,
2000,
1997,
1999,
1990,
1993,
2011,
2010,
2019
] | 10 | [
"IPR005817"
] | [] | 1 | 0 | 1 | [
"Eumetazoa"
] | [
1874
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
3,
5,
5
] | 4 | true | Family | Wnt-3 protein | Wnt-3 protein | Wnt3 | 2 |
IPR009142 | 9,142 | Wnt-4 protein | Wnt4 | Family | 1,094 | false | false | Wnt proteins constitute a large family of secreted molecules that are involved in intercellular signalling during development. The name derives from the first 2 members of the family to be discovered: int-1 (mouse) and wingless (Drosophila) [ ]. It is now recognised that Wnt signalling controls many cell fate decisions... | [
"GO:0005102",
"GO:0007275",
"GO:0016055",
"GO:0005576"
] | [
"signaling receptor binding",
"multicellular organism development",
"Wnt signaling pathway",
"extracellular region"
] | [
"molecular_function",
"biological_process",
"biological_process",
"cellular_component"
] | 4 | [
"PRINTS"
] | [
"PR01844"
] | [
"WNT4PROTEIN"
] | [
1094
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-DRE-3238698",
"R-DRE-4086400",
"R-GGA-3238698",
"R-HSA-201681",
"R-HSA-3238698",
"R-HSA-373080",
"R-HSA-3772470",
"R-HSA-4086400",
"R-HSA-9831926",
"R-MMU-3238698",
"R-MMU-4086400",
"R-RNO-3238698",
"R-RNO-4086400"
] | [
"REACTOME:R-DRE-3238698",
"REACTOME:R-DRE-4086400",
"REACTOME:R-GGA-3238698",
"REACTOME:R-HSA-201681",
"REACTOME:R-HSA-3238698",
"REACTOME:R-HSA-373080",
"REACTOME:R-HSA-3772470",
"REACTOME:R-HSA-4086400",
"REACTOME:R-HSA-9831926",
"REACTOME:R-MMU-3238698",
"REACTOME:R-MMU-4086400",
"REACTOME:... | 13 | [] | 0 | [
"PUB00011232",
"PUB00011233",
"PUB00011234",
"PUB00011562",
"PUB00013890",
"PUB00013894",
"PUB00013895",
"PUB00055528"
] | [
"9891778",
"10967351",
"10733430",
"9192851",
"10508601",
"2279700",
"7990960",
"21536746"
] | [
"Mechanisms of Wnt signaling in development.",
"Wnt signaling function in Alzheimer's disease.",
"Wnt signaling in oncogenesis and embryogenesis--a look outside the nucleus.",
"Human dishevelled genes constitute a DHR-containing multigene family.",
"Wnt signalling shows its versatility.",
"Expression of m... | [
1998,
2000,
2000,
1997,
1999,
1990,
1994,
2011
] | 8 | [
"IPR005817"
] | [] | 1 | 0 | 1 | [
"Bilateria"
] | [
1094
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
4,
2,
4
] | 4 | true | Family | Wnt-4 protein | Wnt-4 protein | Wnt4 | 5 |
IPR009143 | 9,143 | Wnt-6 protein | Wnt6 | Family | 1,422 | false | false | Wnt proteins constitute a large family of secreted molecules that are involved in intercellular signalling during development. The name derives from the first 2 members of the family to be discovered: int-1 (mouse) and wingless (Drosophila) [ ]. It is now recognised that Wnt signalling controls many cell fate decisions... | [
"GO:0005102",
"GO:0007275",
"GO:0016055",
"GO:0005576"
] | [
"signaling receptor binding",
"multicellular organism development",
"Wnt signaling pathway",
"extracellular region"
] | [
"molecular_function",
"biological_process",
"biological_process",
"cellular_component"
] | 4 | [
"CDD"
] | [
"cd19338"
] | [
"Wnt_Wnt6"
] | [
1422
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-3238698",
"R-HSA-373080",
"R-MMU-3238698"
] | [
"REACTOME:R-HSA-3238698",
"REACTOME:R-HSA-373080",
"REACTOME:R-MMU-3238698"
] | 3 | [] | 0 | [
"PUB00011232",
"PUB00011233",
"PUB00011234",
"PUB00011562",
"PUB00013890",
"PUB00013894",
"PUB00013896",
"PUB00055528"
] | [
"9891778",
"10967351",
"10733430",
"9192851",
"10508601",
"2279700",
"11948913",
"21536746"
] | [
"Mechanisms of Wnt signaling in development.",
"Wnt signaling function in Alzheimer's disease.",
"Wnt signaling in oncogenesis and embryogenesis--a look outside the nucleus.",
"Human dishevelled genes constitute a DHR-containing multigene family.",
"Wnt signalling shows its versatility.",
"Expression of m... | [
1998,
2000,
2000,
1997,
1999,
1990,
2002,
2011
] | 8 | [
"IPR005817"
] | [] | 1 | 0 | 1 | [
"Eumetazoa"
] | [
1422
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
1,
3,
1,
2
] | 5 | true | Family | Wnt-6 protein | Wnt-6 protein | Wnt6 | 3 |
IPR009145 | 9,145 | U2 auxiliary factor small subunit | U2AF_small | Family | 9,438 | false | false | The U2 small nuclear ribonucleoprotein auxiliary factor (U2AF) is a heterodimeric splicing factor composed of a large and a small subunit [ ]. The large U2AF subunit recognises the intronic polypyrimidine tract, a sequence located adjacent to the 3' splice site that serves as an important signal for both constitutive a... | [
"GO:0003723",
"GO:0000398",
"GO:0089701"
] | [
"RNA binding",
"mRNA splicing, via spliceosome",
"U2AF complex"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PRINTS",
"PANTHER"
] | [
"PR01848",
"PTHR12620"
] | [
"U2AUXFACTOR",
""
] | [
9206,
9289
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-159236",
"R-BTA-72163",
"R-BTA-72187",
"R-BTA-73856",
"R-DME-159236",
"R-DME-72187",
"R-DME-73856",
"R-HSA-159236",
"R-HSA-72163",
"R-HSA-72165",
"R-HSA-72187",
"R-HSA-73856",
"R-MMU-159236",
"R-MMU-72163",
"R-MMU-72165",
"R-MMU-72187",
"R-MMU-73856",
"R-RNO-159236",
"R-RN... | [
"REACTOME:R-BTA-159236",
"REACTOME:R-BTA-72163",
"REACTOME:R-BTA-72187",
"REACTOME:R-BTA-73856",
"REACTOME:R-DME-159236",
"REACTOME:R-DME-72187",
"REACTOME:R-DME-73856",
"REACTOME:R-HSA-159236",
"REACTOME:R-HSA-72163",
"REACTOME:R-HSA-72165",
"REACTOME:R-HSA-72187",
"REACTOME:R-HSA-73856",
"... | 21 | [
"1jmt",
"4yh8",
"7c06",
"7c07",
"7c08"
] | 5 | [
"PUB00013898",
"PUB00074790",
"PUB00078001",
"PUB00078002",
"PUB00078003",
"PUB00099586"
] | [
"8630064",
"12374752",
"1824937",
"2531895",
"9632785",
"25311244"
] | [
"Absence of imprinting in U2AFBPL, a human homologue of the imprinted mouse gene U2afbp-rs.",
"Pre-spliceosome formation in S.pombe requires a stable complex of SF1-U2AF(59)-U2AF(23).",
"Biochemical characterization of U2 snRNP auxiliary factor: an essential pre-mRNA splicing factor with a novel intranuclear di... | [
1996,
2002,
1991,
1989,
1998,
2015
] | 6 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Winogradskyella ouciana"
] | [
9437,
1
] | 2 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Schizosaccharomyces pombe (stra... | [
14,
1,
5,
5,
14,
25,
1,
9,
14,
1,
28
] | 11 | true | Family | U2 auxiliary factor small subunit | U2 auxiliary factor small subunit | U2AF_small | 9 |
IPR009146 | 9,146 | Groucho/transducin-like enhancer | Groucho_enhance | Family | 13,120 | false | false | The Groucho (Gro)/transducin-like enhancers (TLE) are a family of evolutionarily conserved corepressor proteins that play a critical role in diverse developmental and cellular pathways, including lateral inhibition, segmentation, sex determination, dorsal/ventral pattern formation, terminal pattern formation, and eye d... | [
"GO:0006355",
"GO:0005634"
] | [
"regulation of DNA-templated transcription",
"nucleus"
] | [
"biological_process",
"cellular_component"
] | 2 | [
"PRINTS",
"PANTHER"
] | [
"PR01850",
"PTHR10814"
] | [
"GROUCHOFAMLY",
""
] | [
9718,
13112
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-CEL-201722",
"R-CEL-3769402",
"R-CEL-4641265",
"R-CEL-9764725",
"R-DME-201722",
"R-DME-209421",
"R-DME-209441",
"R-DME-3769402",
"R-DME-4641265",
"R-DME-9764725",
"R-DRE-3769402",
"R-DRE-4641265",
"R-DRE-9018519",
"R-HSA-201722",
"R-HSA-2122947",
"R-HSA-3769402",
"R-HSA-4641265",
... | [
"REACTOME:R-CEL-201722",
"REACTOME:R-CEL-3769402",
"REACTOME:R-CEL-4641265",
"REACTOME:R-CEL-9764725",
"REACTOME:R-DME-201722",
"REACTOME:R-DME-209421",
"REACTOME:R-DME-209441",
"REACTOME:R-DME-3769402",
"REACTOME:R-DME-4641265",
"REACTOME:R-DME-9764725",
"REACTOME:R-DRE-3769402",
"REACTOME:R-... | 28 | [
"1gxr",
"2ce8",
"2ce9",
"4om2",
"4om3",
"5mwj",
"8h93",
"8h94",
"8h95",
"8h96",
"8x7v",
"8x7w",
"8xi3",
"9l4j",
"9l4k",
"9l4l"
] | 16 | [
"PUB00013901",
"PUB00013902",
"PUB00013903"
] | [
"10831834",
"1303292",
"9334241"
] | [
"Groucho/TLE family proteins and transcriptional repression.",
"Human homologs of a Drosophila Enhancer of split gene product define a novel family of nuclear proteins.",
"The Groucho/transducin-like enhancer of split transcriptional repressors interact with the genetically defined amino-terminal silencing doma... | [
2000,
1992,
1997
] | 3 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Sphaerimonospora thailandensis"
] | [
13119,
1
] | 2 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
52,
7,
56,
44,
45
] | 6 | true | Family | Groucho/transducin-like enhancer | Groucho/transducin-like enhancer | Groucho_enhance | 9 |
IPR009147 | 9,147 | Cystic fibrosis transmembrane conductance regulator | CFTR/ABCC7 | Family | 2,398 | false | false | The ABC transporter family is a group of membrane proteins that use the hydrolysis of ATP to power the translocation of a wide variety of substrates across cellular membranes. ABC transporters minimally consist of two conserved regions: a highly conserved nucleotide-binding domain (NBD) and a less conserved transmembra... | [
"GO:0005254",
"GO:0006811",
"GO:0016020"
] | [
"chloride channel activity",
"monoatomic ion transport",
"membrane"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PRINTS",
"NCBIFAM"
] | [
"PR01851",
"TIGR01271"
] | [
"CYSFIBREGLTR",
"CFTR_protein"
] | [
2392,
1348
] | 2 | [
"EC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
... | [
"5.6.1.6",
"R-CFA-382556",
"R-CFA-5627083",
"R-CFA-5689880",
"R-CFA-8856825",
"R-CFA-8856828",
"R-CFA-9013406",
"R-CFA-9646399",
"R-DRE-382556",
"R-DRE-5627083",
"R-DRE-9013406",
"R-DRE-9646399",
"R-HSA-382556",
"R-HSA-5627083",
"R-HSA-5678895",
"R-HSA-5689880",
"R-HSA-8856825",
"R... | [
"EC:5.6.1.6",
"REACTOME:R-CFA-382556",
"REACTOME:R-CFA-5627083",
"REACTOME:R-CFA-5689880",
"REACTOME:R-CFA-8856825",
"REACTOME:R-CFA-8856828",
"REACTOME:R-CFA-9013406",
"REACTOME:R-CFA-9646399",
"REACTOME:R-DRE-382556",
"REACTOME:R-DRE-5627083",
"REACTOME:R-DRE-9013406",
"REACTOME:R-DRE-964639... | 37 | [
"5uak",
"5uar",
"5w81",
"6d3r",
"6d3s",
"6msm",
"6o1v",
"6o2p",
"7sv7",
"7svd",
"7svr",
"8eig",
"8eio",
"8eiq",
"8ej1",
"8fzq",
"8gls",
"8ubr",
"8v7z",
"8v81",
"9dw4",
"9dw5",
"9dw7",
"9dw8",
"9dw9",
"9mxl"
] | 26 | [
"PUB00013905",
"PUB00072552",
"PUB00100468"
] | [
"9922375",
"11441126",
"25330774"
] | [
"Structure and function of the CFTR chloride channel.",
"The human ATP-binding cassette (ABC) transporter superfamily.",
"The major cystic fibrosis causing mutation exhibits defective propensity for phosphorylation."
] | [
1999,
2001,
2015
] | 3 | [] | [] | 0 | 0 | null | [
"Opisthokonta"
] | [
2398
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
30,
4,
8
] | 4 | true | Family | Cystic fibrosis transmembrane conductance regulator | Cystic fibrosis transmembrane conductance regulator | CFTR/ABCC7 | 5 |
IPR009148 | 9,148 | Peptidoglycan hydrolase PcsB-like | PcsB-like | Family | 2,027 | false | false | This entry represents a family of proteins from bacteria and some lower eukaryotes, including Peptidoglycan hydrolase PcsB from Streptococcus pneumoniae. PcsB is required for the maintenance of normal growth and cellular morphology [ , , ] and is involved in the splitting of the septum during cell division [ ]. This pr... | [] | [] | [] | 0 | [
"PRINTS"
] | [
"PR01852"
] | [
"SIBAPROTEIN"
] | [
2027
] | 1 | [
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC"... | [
"3.2.1.-",
"PWY-1921",
"PWY-5821",
"PWY-5976",
"PWY-6527",
"PWY-6717",
"PWY-6735",
"PWY-6737",
"PWY-6749",
"PWY-6784",
"PWY-6821",
"PWY-6848",
"PWY-6855",
"PWY-6906",
"PWY-6972",
"PWY-7056",
"PWY-7057",
"PWY-7074",
"PWY-7091",
"PWY-7133",
"PWY-7134",
"PWY-7256",
"PWY-7445... | [
"EC:3.2.1.-",
"METACYC:PWY-1921",
"METACYC:PWY-5821",
"METACYC:PWY-5976",
"METACYC:PWY-6527",
"METACYC:PWY-6717",
"METACYC:PWY-6735",
"METACYC:PWY-6737",
"METACYC:PWY-6749",
"METACYC:PWY-6784",
"METACYC:PWY-6821",
"METACYC:PWY-6848",
"METACYC:PWY-6855",
"METACYC:PWY-6906",
"METACYC:PWY-6... | 31 | [
"4cgk",
"8dot"
] | 2 | [
"PUB00013907",
"PUB00153385",
"PUB00153386",
"PUB00153387",
"PUB00153388"
] | [
"11447160",
"14651645",
"15306019",
"19270090",
"24804636"
] | [
"Identification and characterization of a novel secreted immunoglobulin binding protein from group A streptococcus.",
"Constitutive expression of PcsB suppresses the requirement for the essential VicR (YycF) response regulator in Streptococcus pneumoniae R6.",
"Defective cell wall synthesis in Streptococcus pne... | [
2001,
2003,
2004,
2009,
2014
] | 5 | [] | [
"IPR058088"
] | 0 | 1 | 0 | [
"Bacteria",
"Candidatus Nitrosomarinus catalinensis",
"Eukaryota",
"metagenomes",
"uncultured Caudovirales phage"
] | [
1684,
1,
339,
2,
1
] | 5 | [] | [] | 0 | true | Family | Peptidoglycan hydrolase PcsB-like | Peptidoglycan hydrolase PcsB-like | PcsB-like | 6 |
IPR009150 | 9,150 | Neuropeptide B/W receptor family | Neuropept_B/W_rcpt | Family | 1,254 | false | false | Two closely related neuropeptide precursors, which share no significant sequence similarity with other known neuropeptides, have recently been identified neuropeptide B and neuropeptide W [ , , ]. Neuropeptide B is expressed in both the central nervous system (CNS) and in the periphery. In the CNS, highest levels of th... | [
"GO:0008188",
"GO:0007186",
"GO:0016020"
] | [
"neuropeptide receptor activity",
"G protein-coupled receptor signaling pathway",
"membrane"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PRINTS"
] | [
"PR01855"
] | [
"NRPEPTIDEWR"
] | [
1254
] | 1 | [
"IUPHAR",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"303",
"R-BTA-375276",
"R-BTA-418594",
"R-HSA-375276",
"R-HSA-418594",
"R-MMU-375276",
"R-MMU-418594",
"R-RNO-375276",
"R-RNO-418594"
] | [
"IUPHAR:303",
"REACTOME:R-BTA-375276",
"REACTOME:R-BTA-418594",
"REACTOME:R-HSA-375276",
"REACTOME:R-HSA-418594",
"REACTOME:R-MMU-375276",
"REACTOME:R-MMU-418594",
"REACTOME:R-RNO-375276",
"REACTOME:R-RNO-418594"
] | 9 | [] | 0 | [
"PUB00013914",
"PUB00013915",
"PUB00013916",
"PUB00063903",
"PUB00063904",
"PUB00064976",
"PUB00066765"
] | [
"12130646",
"12401809",
"12118011",
"7590751",
"15797961",
"12719537",
"15500544"
] | [
"Identification of neuropeptide W as the endogenous ligand for orphan G-protein-coupled receptors GPR7 and GPR8.",
"Identification of natural ligands for the orphan G protein-coupled receptors GPR7 and GPR8.",
"Identification of a neuropeptide modified with bromine as an endogenous ligand for GPR7.",
"The clo... | [
2002,
2003,
2002,
1995,
2005,
2003,
2004
] | 7 | [
"IPR000276"
] | [] | 1 | 0 | 1 | [
"Chordata"
] | [
1254
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
4,
1,
2
] | 4 | true | Family | Neuropeptide B/W receptor family | Neuropeptide B/W receptor family | Neuropept_B/W_rcpt | 1 |
IPR009152 | 9,152 | Cytochrome bc1 complex, cytochrome c subunit | bc1_cytC-su | Family | 4,304 | false | false | Quinol-cytochrome c reductases (also called the cytochrome bc1 complex) constitute a large family of enzymes which transfer electrons from quinols to cytochrome c, translocating protons across membranes in the process. They function in bacterial and mitochondrial repiratory chains, and also the photosythetic electron t... | [
"GO:0005506",
"GO:0009055",
"GO:0020037",
"GO:0016020"
] | [
"iron ion binding",
"electron transfer activity",
"heme binding",
"membrane"
] | [
"molecular_function",
"molecular_function",
"molecular_function",
"cellular_component"
] | 4 | [
"NCBIFAM",
"PIRSF"
] | [
"NF050122",
"PIRSF000007"
] | [
"bc1_QcrC_actin",
"Ubiq_cycred_cyc"
] | [
4304,
4175
] | 2 | [
"EC",
"METACYC",
"METACYC",
"METACYC"
] | [
"7.1.1.8",
"PWY-3781",
"PWY-6692",
"PWY-7279"
] | [
"EC:7.1.1.8",
"METACYC:PWY-3781",
"METACYC:PWY-6692",
"METACYC:PWY-7279"
] | 4 | [
"6adq",
"6hwh",
"7e1v",
"7e1w",
"7e1x",
"7q21",
"7qhm",
"7qho",
"7rh5",
"7rh6",
"7rh7",
"8hcr",
"8ovc",
"8ovd",
"9dm1",
"9ftz",
"9fu0",
"9gy6"
] | 18 | [
"PUB00035558",
"PUB00035559",
"PUB00081475"
] | [
"12446663",
"12615356",
"16159762"
] | [
"Purification of a cytochrome bc-aa3 supercomplex with quinol oxidase activity from Corynebacterium glutamicum. Identification of a fourth subunity of cytochrome aa3 oxidase and mutational analysis of diheme cytochrome c1.",
"QcrCAB operon of a nocardia-form actinomycete Rhodococcus rhodochrous encodes cytochrome... | [
2003,
2003,
2005
] | 3 | [] | [] | 0 | 0 | null | [
"Bacteria",
"metagenomes"
] | [
4166,
138
] | 2 | [] | [] | 0 | true | Family | Cytochrome bc1 complex, cytochrome c subunit | Cytochrome bc1 complex, cytochrome c subunit | bc1_cytC-su | 1 |
IPR009153 | 9,153 | Cytochrome cL | Cyt_cL | Family | 327 | false | false | In Gram-negative bacteria, growth on methanol is dependent on the soluble, periplasmic quinoprotein methanol dehydrogenase, which oxidises methanol to formaldehyde. The electrons generated by this reaction are transferred from the reduced enzyme to the unusual cytochrome cL, which is subsequently oxidised itself by cyt... | [
"GO:0005506",
"GO:0009055",
"GO:0020037",
"GO:0042597"
] | [
"iron ion binding",
"electron transfer activity",
"heme binding",
"periplasmic space"
] | [
"molecular_function",
"molecular_function",
"molecular_function",
"cellular_component"
] | 4 | [
"PIRSF",
"NCBIFAM"
] | [
"PIRSF000008",
"TIGR03872"
] | [
"Cytochrome_c551i",
"cytochrome_MoxG"
] | [
311,
290
] | 2 | [] | [] | [] | 0 | [
"1mg2",
"1mg3",
"2c8s",
"2d0w",
"2gc4",
"2gc7",
"2mta",
"7c90"
] | 8 | [
"PUB00035561",
"PUB00035562"
] | [
"15234264",
"16414073"
] | [
"The quinoprotein dehydrogenases for methanol and glucose.",
"The 1.6A X-ray structure of the unusual c-type cytochrome, cytochrome cL, from the methylotrophic bacterium Methylobacterium extorquens."
] | [
2004,
2006
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"ecological metagenomes"
] | [
323,
4
] | 2 | [] | [] | 0 | true | Family | Cytochrome cL | Cytochrome cL | Cyt_cL | 1 |
IPR009154 | 9,154 | Membrane-bound tetrahaem cytochrome TorC/YecK | Membr-bd_4haem_cyt_TorC | Family | 2,119 | false | false | This family includes TorC, a pentahemic c-type cytochrome subunit of periplasmic reductases for trimethylamine-N-oxide (TMAO). The N-terminal half is closely related to tetrahemic NapC (or NirT) subunits of periplasmic nitrate (or nitrite) reductases; some species have both TMAO and nitrate reductase complexes [ ]. | [
"GO:0005506",
"GO:0009055",
"GO:0020037",
"GO:0009276",
"GO:0016020"
] | [
"iron ion binding",
"electron transfer activity",
"heme binding",
"Gram-negative-bacterium-type cell wall",
"membrane"
] | [
"molecular_function",
"molecular_function",
"molecular_function",
"cellular_component",
"cellular_component"
] | 5 | [
"PIRSF",
"NCBIFAM"
] | [
"PIRSF000014",
"TIGR02162"
] | [
"4_hem_cytch_TorC",
"torC"
] | [
2111,
1135
] | 2 | [
"GP",
"GP",
"GP",
"GP"
] | [
"GenProp1205",
"GenProp1341",
"GenProp1535",
"GenProp1582"
] | [
"GP:GenProp1205",
"GP:GenProp1341",
"GP:GenProp1535",
"GP:GenProp1582"
] | 4 | [] | 0 | [
"PUB00015611"
] | [
"11056172"
] | [
"Electron transfer and binding of the c-type cytochrome TorC to the trimethylamine N-oxide reductase in Escherichia coli."
] | [
2001
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Panagrolaimus superbus"
] | [
2118,
1
] | 2 | [
"Escherichia coli (strain K12)"
] | [
2
] | 1 | true | Family | Membrane-bound tetrahaem cytochrome TorC/YecK | Membrane-bound tetrahaem cytochrome TorC/YecK | Membr-bd_4haem_cyt_TorC | 7 |
IPR009155 | 9,155 | Cytochrome b562 | Cyt_b562 | Family | 2,027 | false | false | Cytochrome b562 is a haem-containing protein that is expressed in the periplasm of Escherichia coli. In b-type cytochromes, the haem atom is not covalently attached to the polypeptide. Cytochrome b562 has a four-helical bundle structure that is structurally similar to that found in members of the cytochrome c family ( ... | [
"GO:0005506",
"GO:0009055",
"GO:0020037",
"GO:0022900",
"GO:0042597"
] | [
"iron ion binding",
"electron transfer activity",
"heme binding",
"electron transport chain",
"periplasmic space"
] | [
"molecular_function",
"molecular_function",
"molecular_function",
"biological_process",
"cellular_component"
] | 5 | [
"PFAM",
"PIRSF"
] | [
"PF07361",
"PIRSF000029"
] | [
"Cytochrom_B562",
"Cytochrome_b562"
] | [
2027,
1225
] | 2 | [] | [] | [] | 0 | [
"1apc",
"1lm3",
"1m6t",
"1qpu",
"1qq3",
"1yyj",
"1yyx",
"1yza",
"1yzc",
"256b",
"2bc5",
"2qla",
"3c62",
"3c63",
"3de8",
"3de9",
"3foo",
"3fop",
"3hni",
"3hnj",
"3hnk",
"3hnl",
"3iq5",
"3iq6",
"3l1m",
"3m15",
"3m4b",
"3m4c",
"3m79",
"3nmi",
"3nmj",
"3nmk"... | 446 | [
"PUB00013996"
] | [
"11914078"
] | [
"A multigeneration analysis of cytochrome b(562) redox variants: evolutionary strategies for modulating redox potential revealed using a library approach."
] | [
2002
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Opisthokonta",
"metagenomes"
] | [
2020,
3,
4
] | 3 | [] | [] | 0 | true | Family | Cytochrome b562 | Cytochrome b562 | Cyt_b562 | 7 |
IPR009157 | 9,157 | Ferredoxin zinc-binding | Fd_Zn-bd | Family | 467 | false | false | This entry represents a group of zinc-binding ferredoxins found in thermophilic archaea [ ]. These proteins consist of two structural domains: a core region which binds a [3Fe-4S] cluster and a [4Fe-S] cluster, and an N-terminal extension [ ]. The core region forms the (β-α-β)2 fold typical of di-cluster ferrodoxins, w... | [
"GO:0008270",
"GO:0009055",
"GO:0051536"
] | [
"zinc ion binding",
"electron transfer activity",
"iron-sulfur cluster binding"
] | [
"molecular_function",
"molecular_function",
"molecular_function"
] | 3 | [
"PIRSF"
] | [
"PIRSF000068"
] | [
"Zn_Fdx_Sulfol"
] | [
467
] | 1 | [] | [] | [] | 0 | [
"1xer",
"2vkr"
] | 2 | [
"PUB00035724",
"PUB00035725"
] | [
"9013590",
"9063899"
] | [
"Novel zinc-containing ferredoxin family in thermoacidophilic archaea.",
"The crystal structure of zinc-containing ferredoxin from the thermoacidophilic archaeon Sulfolobus sp. strain 7."
] | [
1997,
1997
] | 2 | [] | [] | 0 | 0 | null | [
"Archaea",
"mine drainage metagenome"
] | [
466,
1
] | 2 | [] | [] | 0 | true | Family | Ferredoxin zinc-binding | Ferredoxin zinc-binding | Fd_Zn-bd | 1 |
IPR009158 | 9,158 | Glycerol-3-phosphate dehydrogenase, GlpB subunit | G3P_DH_GlpB_su | Family | 2,534 | false | false | This entry represents the GlpB subunit. An archaeal homologue has also recently been characterised [ ], which appears to be used under aerobic conditions in halophilic archaea. In bacteria, glycerol uptake is mediated by the glycerol diffusion facilitator, an integral membrane protein catalysing the rapid equilibration... | [
"GO:0004368",
"GO:0009331"
] | [
"glycerol-3-phosphate dehydrogenase (quinone) activity",
"glycerol-3-phosphate dehydrogenase (FAD) complex"
] | [
"molecular_function",
"cellular_component"
] | 2 | [
"HAMAP",
"PIRSF",
"NCBIFAM"
] | [
"MF_00753",
"PIRSF000141",
"TIGR03378"
] | [
"Glycerol3P_GlpB",
"Anaerobic_G3P_dh",
"glycerol3P_GlpB"
] | [
1677,
2433,
2417
] | 3 | [
"EC",
"GP",
"GP",
"GP",
"GP",
"METACYC",
"METACYC",
"METACYC"
] | [
"1.1.5.3",
"GenProp0737",
"GenProp1391",
"GenProp1676",
"GenProp1729",
"PWY-4261",
"PWY-6118",
"PWY-6952"
] | [
"EC:1.1.5.3",
"GP:GenProp0737",
"GP:GenProp1391",
"GP:GenProp1676",
"GP:GenProp1729",
"METACYC:PWY-4261",
"METACYC:PWY-6118",
"METACYC:PWY-6952"
] | 8 | [] | 0 | [
"PUB00012960",
"PUB00059145",
"PUB00059152"
] | [
"7576488",
"21725010",
"6792201"
] | [
"Physiological role of GlpB of anaerobic glycerol-3-phosphate dehydrogenase of Escherichia coli.",
"Activity and transcriptional regulation of bacterial protein-like glycerol-3-phosphate dehydrogenase of the haloarchaea in Haloferax volcanii.",
"The anaerobic sn-glycerol-3-phosphate dehydrogenase of Escherichia... | [
1995,
2011,
1981
] | 3 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Halobacteriales",
"metagenomes"
] | [
2213,
4,
312,
5
] | 4 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Glycerol-3-phosphate dehydrogenase, GlpB subunit | Glycerol-3-phosphate dehydrogenase, GlpB subunit | G3P_DH_GlpB_su | 1 |
IPR009159 | 9,159 | Dihydrofolate reductase, type II | Dhfr_type_II | Family | 94 | false | false | Dihydrofolate reductase (DHFR) ( ) catalyses the NADPH-dependent reduction of dihydrofolate to tetrahydrofolate, an essential step in de novo synthesis both of glycine and of purines and deoxythymidine phosphate (the precursors of DNA synthesis) [ ], and important also in the conversion of deoxyuridine monophosphate to... | [
"GO:0004146",
"GO:0009410"
] | [
"dihydrofolate reductase activity",
"response to xenobiotic stimulus"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PFAM",
"PIRSF"
] | [
"PF06442",
"PIRSF000199"
] | [
"DHFR_2",
"Dhfr_type_II"
] | [
94,
59
] | 2 | [
"EC",
"METACYC",
"METACYC"
] | [
"1.5.1.3",
"PWY-3841",
"PWY-6614"
] | [
"EC:1.5.1.3",
"METACYC:PWY-3841",
"METACYC:PWY-6614"
] | 3 | [
"1vie",
"1vif",
"2gqv",
"2p4t",
"2rh2",
"2rk1",
"2rk2",
"3sfm",
"6nxz",
"6ny0",
"9cum"
] | 11 | [
"PUB00001361",
"PUB00002379",
"PUB00002387",
"PUB00003657",
"PUB00005107",
"PUB00012390"
] | [
"3383852",
"500653",
"6815178",
"2601715",
"2830673",
"7583655"
] | [
"Crystal structure of human dihydrofolate reductase complexed with folate.",
"Porcine liver dihydrofolate reductase. Purification, properties, and amino acid sequence.",
"Crystal structures of Escherichia coli and Lactobacillus casei dihydrofolate reductase refined at 1.7 A resolution. I. General features and b... | [
1988,
1979,
1982,
1989,
1988,
1995
] | 6 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Caudoviricetes",
"viral metagenome"
] | [
87,
6,
1
] | 3 | [] | [] | 0 | true | Family | Dihydrofolate reductase, type II | Dihydrofolate reductase, type II | Dhfr_type_II | 3 |
IPR009160 | 9,160 | Acyl-CoA desaturase, haem/steroid binding domain-containing | Acyl-CoA_deSatase_haem/ster-bd | Family | 3,319 | false | false | This entry represents acyl-CoA desaturases 1 (also known as stearoyl-CoA desaturase 1 or Ole1) ( ) that contain a C-terminal haem/steroid binding domain (cytochrome b 5 b) in addition to the N-terminal catalytic domain. | [
"GO:0004768",
"GO:0006636",
"GO:0016020"
] | [
"stearoyl-CoA 9-desaturase activity",
"unsaturated fatty acid biosynthetic process",
"membrane"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PIRSF"
] | [
"PIRSF000345"
] | [
"OLE1"
] | [
3319
] | 1 | [
"EC",
"METACYC",
"METACYC",
"REACTOME",
"REACTOME"
] | [
"1.14.19.1",
"PWY-5987",
"PWY-5996",
"R-SCE-75105",
"R-SPO-75105"
] | [
"EC:1.14.19.1",
"METACYC:PWY-5987",
"METACYC:PWY-5996",
"REACTOME:R-SCE-75105",
"REACTOME:R-SPO-75105"
] | 5 | [] | 0 | [
"PUB00002590",
"PUB00004734",
"PUB00013524",
"PUB00013525"
] | [
"1978720",
"2006187",
"9767077",
"12440977"
] | [
"The OLE1 gene of Saccharomyces cerevisiae encodes the delta 9 fatty acid desaturase and can be functionally replaced by the rat stearoyl-CoA desaturase gene.",
"Stearoyl-acyl-carrier-protein desaturase from higher plants is structurally unrelated to the animal and fungal homologs.",
"Structure and expression o... | [
1990,
1991,
1998,
2002
] | 4 | [
"IPR015876"
] | [] | 1 | 0 | 1 | [
"Bacteria",
"Eukaryota",
"hydrothermal vent metagenome"
] | [
58,
3260,
1
] | 3 | [
"Drosophila melanogaster",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
3,
1,
1,
1
] | 4 | true | Family | Acyl-CoA desaturase, haem/steroid binding domain-containing | Acyl-CoA desaturase, haem/steroid binding domain-containing | Acyl-CoA_deSatase_haem/ster-bd | 5 |
IPR009161 | 9,161 | ATP-dependent 6-phosphofructokinase, eukaryotic-type | 6-Pfructokinase_euk | Family | 8,796 | false | false | Phosphofructokinase (PFK) catalyses the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate, which then enters the Embden-Meyerhof pathway. PFK is a key regulatory enzyme in glycolysis. This entry represent eukaryotic type of ATP-dependent PFKs. They belong to the PFK domain superfamily of proteins, whi... | [
"GO:0003872",
"GO:0005524",
"GO:0006096",
"GO:0005737"
] | [
"6-phosphofructokinase activity",
"ATP binding",
"glycolytic process",
"cytoplasm"
] | [
"molecular_function",
"molecular_function",
"biological_process",
"cellular_component"
] | 4 | [
"HAMAP",
"PIRSF",
"NCBIFAM"
] | [
"MF_03184",
"PIRSF000533",
"TIGR02478"
] | [
"Phosphofructokinase_I_E",
"ATP_PFK_euk",
"6PF1K_euk"
] | [
6781,
7851,
8234
] | 3 | [
"EC",
"GP",
"GP",
"GP",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"2.7.1.11",
"GenProp0694",
"GenProp1580",
"GenProp1599",
"PWY-1042",
"PWY-1861",
"PWY-5484",
"PWY-7385",
"R-BTA-6798695",
"R-BTA-70171",
"R-CEL-6798695",
"R-CEL-70171",
"R-DME-6798695",
"R-DME-70171",
"R-HSA-6798695",
"R-HSA-70171",
"R-MMU-6798695",
"R-MMU-70171",
"R-RNO-6798695"... | [
"EC:2.7.1.11",
"GP:GenProp0694",
"GP:GenProp1580",
"GP:GenProp1599",
"METACYC:PWY-1042",
"METACYC:PWY-1861",
"METACYC:PWY-5484",
"METACYC:PWY-7385",
"REACTOME:R-BTA-6798695",
"REACTOME:R-BTA-70171",
"REACTOME:R-CEL-6798695",
"REACTOME:R-CEL-70171",
"REACTOME:R-DME-6798695",
"REACTOME:R-DME... | 24 | [
"3o8l",
"3o8n",
"3o8o",
"3opy",
"4omt",
"4rh3",
"4u1r",
"4wl0",
"4xyj",
"4xyk",
"4xz2",
"7lw1",
"7tff",
"8w2g",
"8w2h",
"8w2i",
"8w2j"
] | 17 | [
"PUB00013526",
"PUB00013527",
"PUB00013529",
"PUB00014634"
] | [
"10091602",
"2139864",
"8326866",
"14585511"
] | [
"Genetic and biochemical characterization of phosphofructokinase from the opportunistic pathogenic yeast Candida albicans.",
"The structure of the human liver-type phosphofructokinase gene.",
"Molecular genetics of phosphofructokinase in the yeast Kluyveromyces lactis.",
"Rampant horizontal gene transfer and ... | [
1999,
1990,
1993,
2003
] | 4 | [
"IPR022953"
] | [
"IPR041914"
] | 1 | 1 | 0 | [
"Bacteria",
"Eukaryota",
"ecological metagenomes"
] | [
266,
8528,
2
] | 3 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strai... | [
2,
27,
6,
14,
5,
1,
19,
2,
1
] | 9 | true | Family | ATP-dependent 6-phosphofructokinase, eukaryotic-type | ATP-dependent 6-phosphofructokinase, eukaryotic-type | 6-Pfructokinase_euk | 2 |
IPR009162 | 9,162 | RNA polymerase, 30kDa subunit, chordopox-type | RNA_pol_30_chordopoxvir-type | Family | 248 | false | false | All three classes of poxvirus genes -early, intermediate and late -are transcribed by the viral RNA polymerase compex [ ]. This complex is composed of nine distinct subunits which total more than 500kDa in mass. The two largest subunits (147 and 136kDa) are homologous to the largest subunits of eukaryotic and prokaryot... | [
"GO:0003677",
"GO:0003899",
"GO:0006351"
] | [
"DNA binding",
"DNA-directed RNA polymerase activity",
"DNA-templated transcription"
] | [
"molecular_function",
"molecular_function",
"biological_process"
] | 3 | [
"PIRSF"
] | [
"PIRSF000745"
] | [
"VAC_RPO30"
] | [
248
] | 1 | [
"EC"
] | [
"2.7.7.6"
] | [
"EC:2.7.7.6"
] | 1 | [
"6rfl",
"6ric",
"6rid",
"6rie",
"7amv",
"7aof",
"7aoh",
"7aoz",
"7ap8",
"7ap9",
"8c8h",
"8p0j",
"8p0k",
"8p0n",
"8rqk",
"9ex9",
"9fpy",
"9fq6"
] | 18 | [
"PUB00003664",
"PUB00035728",
"PUB00035729"
] | [
"2398897",
"12917449",
"2214020"
] | [
"Identification of rpo30, a vaccinia virus RNA polymerase gene with structural similarity to a eucaryotic transcription elongation factor.",
"Vaccinia virus transcription.",
"Vaccinia virus gene encoding a 30-kilodalton subunit of the viral DNA-dependent RNA polymerase."
] | [
1990,
2003,
1990
] | 3 | [] | [] | 0 | 0 | null | [
"Poxviridae"
] | [
248
] | 1 | [] | [] | 0 | true | Family | RNA polymerase, 30kDa subunit, chordopox-type | RNA polymerase, 30kDa subunit, chordopox-type | RNA_pol_30_chordopoxvir-type | 9 |
IPR009164 | 9,164 | Fructose-1,6-bisphosphatase class 3 | FBPtase_class3 | Family | 3,319 | false | false | Fructose 1,6-bisphosphatase catalyses the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate [ ]. This is an essential reaction in the process of gluconeogenesis, the process by which non-carbohydrate precursors are converted to glucose, and hence this enzyme is found almost universally. Enzyme activity ca... | [
"GO:0042132",
"GO:0006094"
] | [
"fructose 1,6-bisphosphate 1-phosphatase activity",
"gluconeogenesis"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"HAMAP",
"PFAM",
"PIRSF"
] | [
"MF_01854",
"PF06874",
"PIRSF000906"
] | [
"FBPase_class3",
"FBPase_2",
"FBPtase_Bacill"
] | [
3109,
3319,
2572
] | 3 | [
"EC",
"GP",
"METACYC"
] | [
"3.1.3.11",
"GenProp0120",
"PWY-5484"
] | [
"EC:3.1.3.11",
"GP:GenProp0120",
"METACYC:PWY-5484"
] | 3 | [] | 0 | [
"PUB00000179",
"PUB00012889",
"PUB00035738",
"PUB00068782"
] | [
"3008716",
"9696785",
"221467",
"19270101"
] | [
"Amino acid sequence homology among fructose-1,6-bisphosphatases.",
"Identification and expression of the Bacillus subtilis fructose-1, 6-bisphosphatase gene (fbp).",
"Purification and properties of fructose-1,6-bisphosphatase of Bacillus subtilis.",
"The Bacillus subtilis ywjI (glpX) gene encodes a class II ... | [
1986,
1998,
1979,
2009
] | 4 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
3252,
13,
54
] | 3 | [] | [] | 0 | true | Family | Fructose-1,6-bisphosphatase class 3 | Fructose-1,6-bisphosphatase class 3 | FBPtase_class3 | 4 |
IPR009166 | 9,166 | Annexin A13 | ANX13 | Family | 625 | false | false | The annexins (or lipocortins) are a family of proteins that bind to phospholipids in a calcium-dependent manner [ ]. The 12 annexins common to vertebrates are classified in the annexin A family and named as annexins A1-A13 (or ANXA1-ANXA13), leaving A12 unassigned in the official nomenclature. Annexins outside vertebra... | [
"GO:0005509",
"GO:0005544"
] | [
"calcium ion binding",
"calcium-dependent phospholipid binding"
] | [
"molecular_function",
"molecular_function"
] | 2 | [
"PRINTS"
] | [
"PR01811"
] | [
"ANNEXINXIII"
] | [
625
] | 1 | [] | [] | [] | 0 | [
"6b3i"
] | 1 | [
"PUB00001395",
"PUB00013921",
"PUB00013941",
"PUB00015121"
] | [
"1646719",
"9797403",
"1530946",
"15059252"
] | [
"Amino acid sequence analysis of the annexin super-gene family of proteins.",
"Identification of the first fungal annexin: analysis of annexin gene duplications and implications for eukaryotic evolution.",
"A strategy for isolation of cDNAs encoding proteins affecting human intestinal epithelial cell growth and... | [
1991,
1998,
1992,
2004
] | 4 | [
"IPR001464"
] | [] | 1 | 0 | 1 | [
"Vertebrata"
] | [
625
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
4,
1,
3
] | 3 | true | Family | Annexin A13 | Annexin A13 | ANX13 | 9 |
IPR009167 | 9,167 | Erythropoietin receptor | Erythropoietin_rcpt | Family | 427 | false | false | A number of receptors for lymphokines, hematopoietic growth factors and growth hormone-related molecules have been found to share a common binding domain. These receptors are designated as hematopoietin receptors [ ] and the corresponding ligands as hematopoietins. Further, hematopoietins have been subdivided into two ... | [
"GO:0004888",
"GO:0016020"
] | [
"transmembrane signaling receptor activity",
"membrane"
] | [
"molecular_function",
"cellular_component"
] | 2 | [
"PIRSF"
] | [
"PIRSF001959"
] | [
"EPO_receptor"
] | [
427
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-9006335",
"R-HSA-9027276",
"R-HSA-9027277",
"R-HSA-9027283",
"R-HSA-9027284",
"R-MMU-9006335",
"R-MMU-9027276",
"R-MMU-9027284",
"R-RNO-9006335",
"R-RNO-9027276",
"R-RNO-9027284",
"R-SSC-9006335",
"R-SSC-9027276",
"R-SSC-9027284"
] | [
"REACTOME:R-HSA-9006335",
"REACTOME:R-HSA-9027276",
"REACTOME:R-HSA-9027277",
"REACTOME:R-HSA-9027283",
"REACTOME:R-HSA-9027284",
"REACTOME:R-MMU-9006335",
"REACTOME:R-MMU-9027276",
"REACTOME:R-MMU-9027284",
"REACTOME:R-RNO-9006335",
"REACTOME:R-RNO-9027276",
"REACTOME:R-RNO-9027284",
"REACTOM... | 14 | [] | 0 | [
"PUB00003648",
"PUB00006639",
"PUB00006640",
"PUB00020723",
"PUB00020724"
] | [
"3773894",
"1549776",
"1400369",
"8068943",
"8657137"
] | [
"Murine erythropoietin gene: cloning, expression, and human gene homology.",
"Human growth hormone and extracellular domain of its receptor: crystal structure of the complex.",
"The interleukin-4-related lymphokines and their binding to hematopoietin receptors.",
"Erythropoietin induces association of the JAK... | [
1986,
1992,
1992,
1994,
1996
] | 5 | [] | [] | 0 | 0 | null | [
"Gnathostomata"
] | [
427
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
1,
2,
3
] | 4 | true | Family | Erythropoietin receptor | Erythropoietin receptor | Erythropoietin_rcpt | 6 |
IPR009169 | 9,169 | Calreticulin | Calreticulin | Family | 4,430 | false | false | Calreticulin is a ubiquitous protein found in a wide range of species and in all nucleated cell types. It is an ancient and highly conserved protein with an exceptionally wide scope and variety of functions. Initially known as the high-affinity calcium-binding endoplasmic reticulum (ER) and sarcoplamic reticulum (SR) p... | [
"GO:0005509",
"GO:0051082",
"GO:0006457",
"GO:0005783"
] | [
"calcium ion binding",
"unfolded protein binding",
"protein folding",
"endoplasmic reticulum"
] | [
"molecular_function",
"molecular_function",
"biological_process",
"cellular_component"
] | 4 | [
"PIRSF"
] | [
"PIRSF002356"
] | [
"Calreticulin"
] | [
4430
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-CEL-901042",
"R-DDI-901042",
"R-DME-901042",
"R-HSA-1236974",
"R-HSA-168316",
"R-HSA-3000480",
"R-HSA-3000484",
"R-HSA-381183",
"R-HSA-901042",
"R-HSA-983170",
"R-MMU-1236974",
"R-MMU-3000480",
"R-MMU-901042",
"R-MMU-983170",
"R-RNO-1236974",
"R-RNO-3000480",
"R-RNO-901042",
"R-... | [
"REACTOME:R-CEL-901042",
"REACTOME:R-DDI-901042",
"REACTOME:R-DME-901042",
"REACTOME:R-HSA-1236974",
"REACTOME:R-HSA-168316",
"REACTOME:R-HSA-3000480",
"REACTOME:R-HSA-3000484",
"REACTOME:R-HSA-381183",
"REACTOME:R-HSA-901042",
"REACTOME:R-HSA-983170",
"REACTOME:R-MMU-1236974",
"REACTOME:R-MMU... | 22 | [
"6eny",
"7qpd",
"8tzo",
"8tzr"
] | 4 | [
"PUB00000513",
"PUB00011766",
"PUB00013543",
"PUB00013544",
"PUB00013545",
"PUB00013546",
"PUB00013547"
] | [
"1497605",
"11248044",
"12445456",
"9038332",
"10085286",
"11375414",
"9693955"
] | [
"Calreticulin.",
"NMR structure of the calreticulin P-domain.",
"Calreticulin in cardiac development and pathology.",
"ER quality control: the cytoplasmic connection.",
"Calreticulin is essential for cardiac development.",
"Complete heart block and sudden death in mice overexpressing calreticulin.",
"Ca... | [
1992,
2001,
2002,
1997,
1999,
2001,
1998
] | 7 | [
"IPR001580"
] | [] | 1 | 0 | 1 | [
"Eukaryota"
] | [
4430
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
19,
1,
3,
3,
6,
7,
11,
13,
26
] | 9 | true | Family | Calreticulin | Calreticulin | Calreticulin | 1 |
IPR009170 | 9,170 | PR domain zinc finger protein 2 | PRDM2 | Family | 792 | false | false | PRDM2 (also known as RIZ) is a transcriptional regulator and tumour suppressor that catalyzes methylation of lysine 9 of histone H3. Its PR domain is responsible for its catalytic activity [ ]. PRDM2 belongs to the PRDM family, whose members are characterised by the presence of an N-terminal PR (PRDI-BF1 and RIZ1 homol... | [
"GO:0042054"
] | [
"histone methyltransferase activity"
] | [
"molecular_function"
] | 1 | [
"PIRSF"
] | [
"PIRSF002395"
] | [
"RIZ_SET"
] | [
792
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00048100",
"PUB00095964",
"PUB00095965"
] | [
"18082620",
"24095733",
"25640033"
] | [
"Structural studies of the SET domain from RIZ1 tumor suppressor.",
"Molecular basis for the regulation of the H3K4 methyltransferase activity of PRDM9.",
"Structural and functional characterization of the acidic region from the RIZ tumor suppressor."
] | [
2008,
2013,
2015
] | 3 | [] | [] | 0 | 0 | null | [
"Sarcopterygii"
] | [
792
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
2,
6
] | 3 | true | Family | PR domain zinc finger protein 2 | PR domain zinc finger protein 2 | PRDM2 | 1 |
IPR009172 | 9,172 | Orthopoxvirus C13 | Orthopox_C13 | Family | 53 | false | false | This group represents an uncharacterised conserved protein belonging to the poxvirus C13 family [ ]. Members of this protein family are also known as Protein OPG209. | [] | [] | [] | 0 | [
"PIRSF"
] | [
"PIRSF003692"
] | [
"VAC_C14L"
] | [
53
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00013557"
] | [
"2783466"
] | [
"Vaccinia virus encodes two proteins that are structurally related to members of the plasma serine protease inhibitor superfamily."
] | [
1989
] | 1 | [] | [] | 0 | 0 | null | [
"Orthopoxvirus"
] | [
53
] | 1 | [] | [] | 0 | true | Family | Orthopoxvirus C13 | Orthopoxvirus C13 | Orthopox_C13 | 2 |
IPR009173 | 9,173 | Chemokine-binding protein, viral | Chemkine-bd_vir | Family | 114 | false | false | This entry includes a group of chemokine binding proteins, including C23L from Vaccinia virus. C23L inhibits host immune defense by binding to host chemokines. It binds host CC chemokines (beta chemokines) such as RANTES with high affinity, but not CXC or C chemokines (alpha and gamma chemokines). This entry also inclu... | [] | [] | [] | 0 | [
"PIRSF"
] | [
"PIRSF003696"
] | [
"VAC_C23L"
] | [
114
] | 1 | [] | [] | [] | 0 | [
"1cq3",
"2ffk",
"2fin",
"2grk"
] | 4 | [
"PUB00077115"
] | [
"9551896"
] | [
"Blockade of chemokine activity by a soluble chemokine binding protein from vaccinia virus."
] | [
1998
] | 1 | [
"IPR003184"
] | [] | 1 | 0 | 1 | [
"Chordopoxvirinae"
] | [
114
] | 1 | [] | [] | 0 | true | Family | Chemokine-binding protein, viral | Chemokine-binding protein, viral | Chemkine-bd_vir | 9 |
IPR009174 | 9,174 | Orthopoxvirus, Protein K7 | Orthopox_K7 | Family | 59 | false | false | This family represents Protein K7 from Orthopoxvirus. K7 is Bcl-2-like protein which, through its interaction with the DEAD box RNA helicase DDX3X/DDX3, prevents TBK1/IKKepsilon-mediated IRF3 activation [ ]. It contributes to virulence by binding to the host TRAF6 and IRAK2 and preventing host NF-kappa-B activation and... | [
"GO:0052031"
] | [
"symbiont-mediated perturbation of host defense response"
] | [
"biological_process"
] | 1 | [
"PIRSF"
] | [
"PIRSF003764"
] | [
"VAC_K7R"
] | [
59
] | 1 | [] | [] | [] | 0 | [
"2k36",
"3jrv"
] | 2 | [
"PUB00048207",
"PUB00061428",
"PUB00100029",
"PUB00100031",
"PUB00100032"
] | [
"18845156",
"19913487",
"18636090",
"28257484",
"23580427"
] | [
"Poxvirus K7 protein adopts a Bcl-2 fold: biochemical mapping of its interactions with human DEAD box RNA helicase DDX3.",
"Structural basis for targeting of human RNA helicase DDX3 by poxvirus protein K7.",
"Viral targeting of DEAD box protein 3 reveals its role in TBK1/IKKepsilon-mediated IRF activation.",
... | [
2009,
2009,
2008,
2017,
2013
] | 5 | [
"IPR022819"
] | [] | 1 | 0 | 1 | [
"Orthopoxvirus"
] | [
59
] | 1 | [] | [] | 0 | true | Family | Orthopoxvirus, Protein K7 | Orthopoxvirus, Protein K7 | Orthopox_K7 | 4 |
IPR009175 | 9,175 | Poxvirus I2 | Poxvirus_I2 | Family | 103 | false | false | This entry represents Protein I2 from Vaccinia virus, also known as Protein OPG078, and similar sequences from poxvirus. I2 is a late protein which probably plays a role in virus entry into the host cell [ ]. | [] | [] | [] | 0 | [
"PFAM",
"PIRSF"
] | [
"PF12575",
"PIRSF003766"
] | [
"Pox_EPC_I2-L1",
"VAC_I2L"
] | [
103,
97
] | 2 | [] | [] | [] | 0 | [] | 0 | [
"PUB00103646"
] | [
"18701587"
] | [
"The vaccinia virus gene I2L encodes a membrane protein with an essential role in virion entry."
] | [
2008
] | 1 | [] | [] | 0 | 0 | null | [
"Poxviridae"
] | [
103
] | 1 | [] | [] | 0 | true | Family | Poxvirus I2 | Poxvirus I2 | Poxvirus_I2 | 2 |
IPR009176 | 9,176 | Vaccinia virus, B7/C8 | Vaccinia_virus_B7/C8 | Family | 136 | false | false | This entry is represented by the Vaccinia virus, B7 and C8 proteins; they are families of uncharacterised viral proteins. B7, also known as Protein OPG192, resides in the host endoplasmic reticulum [ ]. | [] | [] | [] | 0 | [
"PIRSF"
] | [
"PIRSF003778"
] | [
"VAC_C8L"
] | [
136
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00103647"
] | [
"10648184"
] | [
"Vaccinia virus gene B7R encodes an 18-kDa protein that is resident in the endoplasmic reticulum and affects virus virulence."
] | [
2000
] | 1 | [] | [] | 0 | 0 | null | [
"Orthopoxvirus"
] | [
136
] | 1 | [] | [] | 0 | true | Family | Vaccinia virus, B7/C8 | Vaccinia virus, B7/C8 | Vaccinia_virus_B7/C8 | 3 |
IPR009177 | 9,177 | Orthopoxvirus C5 | Orthopox_C5 | Family | 63 | false | false | This group represents uncharacterised conserved proteins belonging to the poxviruses C5 family. C5 is also known as Protein OPG030. | [] | [] | [] | 0 | [
"PIRSF"
] | [
"PIRSF003781"
] | [
"VAC_C5L"
] | [
63
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Orthopoxvirus"
] | [
63
] | 1 | [] | [] | 0 | true | Family | Orthopoxvirus C5 | Orthopoxvirus C5 | Orthopox_C5 | 7 |
IPR009179 | 9,179 | Protein E3 | E3L | Family | 255 | false | false | RNA-binding protein E3 from Vaccinia virus (E3L, also known as RNA-binding protein OPG065) is a dsRNA-binding protein capable of inhibiting protein kinase R and is an effective IRF3 and -7 phosphorylation inhibitor [ ]. It inhibits NF-kappa-B activation and the ubiquitin-like protein ISG15, which is an early antiviral ... | [
"GO:0003723",
"GO:0052027"
] | [
"RNA binding",
"symbiont-mediated perturbation of host signal transduction pathway"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PIRSF"
] | [
"PIRSF004008"
] | [
"VAC_E3L"
] | [
255
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00078884",
"PUB00078885",
"PUB00100310",
"PUB00103648",
"PUB00103649",
"PUB00103650",
"PUB00103651"
] | [
"11124948",
"15207627",
"1681618",
"34192517",
"29073079",
"24257616",
"18604270"
] | [
"IRF3 and IRF7 phosphorylation in virus-infected cells does not require double-stranded RNA-dependent protein kinase R or Ikappa B kinase but is blocked by Vaccinia virus E3L protein.",
"Inhibition of PKR by vaccinia virus: role of the N- and C-terminal domains of E3L.",
"Characterization of a vaccinia virus-en... | [
2001,
2004,
1991,
2021,
2017,
2014,
2008
] | 7 | [] | [] | 0 | 0 | null | [
"Chordopoxvirinae"
] | [
255
] | 1 | [] | [] | 0 | true | Family | Protein E3 | Protein E3 | E3L | 9 |
IPR009181 | 9,181 | Methanogenesis marker 8 protein | Methan_mark_8 | Family | 339 | false | false | The exact function of this protein is unknown, but likely is linked to methanogenesis or a process closely connected to it [ ]. | [] | [] | [] | 0 | [
"PFAM",
"PIRSF",
"NCBIFAM"
] | [
"PF09872",
"PIRSF004929",
"TIGR03275"
] | [
"DUF2099",
"UCP004929",
"methan_mark_8"
] | [
339,
293,
310
] | 3 | [
"GP"
] | [
"GenProp0722"
] | [
"GP:GenProp0722"
] | 1 | [] | 0 | [
"PUB00060475"
] | [
"22070167"
] | [
"ProPhylo: partial phylogenetic profiling to guide protein family construction and assignment of biological process."
] | [
2011
] | 1 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"ecological metagenomes"
] | [
326,
4,
9
] | 3 | [] | [] | 0 | true | Family | Methanogenesis marker 8 protein | Methanogenesis marker 8 protein | Methan_mark_8 | 1 |
IPR009183 | 9,183 | MTH_862/MJ1183 | MTH_862/MJ1183 | Family | 218 | false | false | This entry includes Uncharacterized protein MTH_862 and Uncharacterized protein MJ1183 from archaea. | [] | [] | [] | 0 | [
"PFAM",
"PIRSF"
] | [
"PF09897",
"PIRSF004962"
] | [
"DUF2124",
"UCP004962"
] | [
218,
203
] | 2 | [] | [] | [] | 0 | [
"2r47"
] | 1 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"hydrocarbon metagenome"
] | [
215,
3
] | 2 | [] | [] | 0 | true | Family | MTH_862/MJ1183 | MTH_862/MJ1183 | MTH_862/MJ1183 | 8 |
IPR009185 | 9,185 | Predicted nucleotidyltransferase | Nucleotidl_trans | Family | 203 | false | false | Detailed sequence analysis suggests that members of this family represent the minimal domain of the PolB nucleotidyltransferase superfamily [ ]. The conservation of the nucleotidyltransferase core and particularly the negatively charged metal-chelating residues lead to the prediction that members of this family possess... | [] | [] | [] | 0 | [
"PIRSF"
] | [
"PIRSF005928"
] | [
"Nucleotidltrnsf"
] | [
203
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00013566",
"PUB00013567"
] | [
"10075991",
"8218273"
] | [
"DNA polymerase beta-like nucleotidyltransferase superfamily: identification of three new families, classification and evolutionary history.",
"Molecular structure of kanamycin nucleotidyltransferase determined to 3.0-A resolution."
] | [
1999,
1993
] | 2 | [
"IPR052038"
] | [] | 1 | 0 | 1 | [
"Archaea",
"marine sediment metagenome"
] | [
198,
5
] | 2 | [] | [] | 0 | true | Family | Predicted nucleotidyltransferase | Predicted nucleotidyltransferase | Nucleotidl_trans | 8 |
IPR009186 | 9,186 | Predicted nickel metalloenzyme maturation factor, AIR synthase-related | Ni_metllenz_mat | Family | 289 | false | false | The large subunit of [NiFe]-hydrogenase--as well as other nickel metalloenzymes--is synthesized as a precursor devoid of the metalloenzyme active site. This precursor then undergoes a complex post-translational maturation process that requires a number of accessory proteins [ , ]. One such group of accessory proteins i... | [] | [] | [] | 0 | [
"PIRSF",
"CDD"
] | [
"PIRSF006346",
"cd02691"
] | [
"Ni_metllenz_mat",
"PurM-like2"
] | [
276,
278
] | 2 | [] | [] | [] | 0 | [] | 0 | [
"PUB00013568",
"PUB00013569",
"PUB00013571",
"PUB00013572",
"PUB00047041"
] | [
"11336840",
"12196162",
"1482271",
"7906310",
"11006546"
] | [
"Maturation of the [NiFe] hydrogenases.",
"Metal insertion into NiFe-hydrogenases.",
"The hyp operon gene products are required for the maturation of catalytically active hydrogenase isoenzymes in Escherichia coli.",
"The hypE gene completes the gene cluster for H2-oxidation in Azotobacter vinelandii.",
"Mo... | [
2001,
2002,
1992,
1994,
2000
] | 5 | [
"IPR006283"
] | [] | 1 | 0 | 1 | [
"Archaea",
"ecological metagenomes"
] | [
285,
4
] | 2 | [] | [] | 0 | true | Family | Predicted nickel metalloenzyme maturation factor, AIR synthase-related | Predicted nickel metalloenzyme maturation factor, AIR synthase-related | Ni_metllenz_mat | 7 |
IPR009187 | 9,187 | Non-homologous end joining protein Ku, prokaryotic type | Prok_Ku | Family | 12,867 | false | false | This superfamily consists of prokaryotic Ku domain containing proteins. In the eukaryotes it has been shown that the Ku protein is involved in repairing DNA double-strand breaks by non-homologous end-joining [ , ]. The Ku protein is a heterodimer of approximately 70kDa and 80kDa subunits [ ]. Both these subunits have s... | [] | [] | [] | 0 | [
"HAMAP",
"PIRSF",
"PANTHER",
"NCBIFAM",
"CDD"
] | [
"MF_01875",
"PIRSF006493",
"PTHR41251",
"TIGR02772",
"cd00789"
] | [
"Prokaryotic_Ku",
"Prok_Ku",
"",
"Ku_bact",
"KU_like"
] | [
12160,
11546,
12867,
12294,
10575
] | 5 | [
"GP"
] | [
"GenProp0492"
] | [
"GP:GenProp0492"
] | 1 | [
"9vnq"
] | 1 | [
"PUB00007946",
"PUB00007947",
"PUB00013573",
"PUB00013574",
"PUB00013575",
"PUB00013576",
"PUB00013577"
] | [
"11483577",
"11493912",
"11839498",
"10377944",
"11445083",
"11516951",
"9477961"
] | [
"Prokaryotic homologs of the eukaryotic DNA-end-binding protein Ku, novel domains in the Ku protein and prediction of a prokaryotic double-strand break repair system.",
"Structure of the Ku heterodimer bound to DNA and its implications for double-strand break repair.",
"DNA double-strand break repair from head ... | [
2001,
2001,
2002,
1999,
2001,
2001,
1998
] | 7 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"metagenomes"
] | [
27,
12751,
10,
19,
60
] | 5 | [] | [] | 0 | true | Family | Non-homologous end joining protein Ku, prokaryotic type | Non-homologous end joining protein Ku, prokaryotic type | Prok_Ku | 3 |
IPR009188 | 9,188 | [NiFe]-hydrogenase maturation factor, HypX/HoxX type | NiFe-hyd_mat_HypX/HoxX | Family | 1,138 | false | false | [NiFe] hydrogenases function in H2 metabolism in a variety of microorganisms, enabling them to use H2 as a source of reducing equivalent under aerobic and anaerobic conditions [NiFe] hydrogenases consist of two subunits, hydrogenase large and hydrogenase small. The large subunit contains the binuclear [NiFe] active sit... | [] | [] | [] | 0 | [
"PIRSF"
] | [
"PIRSF006787"
] | [
"Hydrgn_mat_HoxX"
] | [
1138
] | 1 | [] | [] | [] | 0 | [
"6j0p",
"6j1e",
"6j1f",
"6j1g",
"6j1h",
"6j1i",
"6j1j"
] | 7 | [
"PUB00013568",
"PUB00013569",
"PUB00013579",
"PUB00013580",
"PUB00013581",
"PUB00035518"
] | [
"11336840",
"12196162",
"9799290",
"8842143",
"9171416",
"15119826"
] | [
"Maturation of the [NiFe] hydrogenases.",
"Metal insertion into NiFe-hydrogenases.",
"hoxX (hypX) is a functional member of the Alcaligenes eutrophus hyp gene cluster.",
"The hydrogenase gene cluster of Rhizobium leguminosarum bv. viciae contains an additional gene (hypX), which encodes a protein with sequenc... | [
2001,
2002,
1998,
1996,
1997,
2004
] | 6 | [
"IPR047180"
] | [] | 1 | 0 | 1 | [
"Bacteria",
"Zooxanthella nutricula",
"ecological metagenomes"
] | [
1132,
1,
5
] | 3 | [] | [] | 0 | true | Family | [NiFe]-hydrogenase maturation factor, HypX/HoxX type | [NiFe]-hydrogenase maturation factor, HypX/HoxX type | NiFe-hyd_mat_HypX/HoxX | 6 |
IPR009190 | 9,190 | Protein of unknown function DUF1462 | DUF1462 | Family | 1,265 | false | false | There are currently no experimental data for members of this group of bacterial proteins or their homologues. A crystal structure of revealed a thioredoxin-like fold, its core consisting of three layers α/β/α. | [] | [] | [] | 0 | [
"PFAM",
"PIRSF"
] | [
"PF07315",
"PIRSF010603"
] | [
"DUF1462",
"UCP010603"
] | [
1265,
1052
] | 2 | [] | [] | [] | 0 | [
"1xg8"
] | 1 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"ecological metagenomes"
] | [
1263,
2
] | 2 | [] | [] | 0 | true | Family | Protein of unknown function DUF1462 | Protein of unknown function DUF1462 | DUF1462 | 4 |
IPR009191 | 9,191 | Diol dehydratase-reactivating factor large subunit | DDRA | Family | 1,752 | false | false | Members of this family are the large (alpha) subunit of the alpha-2/beta-2 tetrameric enzyme that reactivates B12-dependent trimeric diol dehydratases (1,2-propanediol dehydratase, glycerol dehydratase). Note that the beta subunit of the reactivase is homologous to the beta (medium) subunit of the diol dehydratase. The... | [] | [] | [] | 0 | [
"PIRSF",
"NCBIFAM"
] | [
"PIRSF011502",
"TIGR04491"
] | [
"DdrA_PduG",
"reactive_PduG"
] | [
1279,
1751
] | 2 | [
"GP"
] | [
"GenProp1089"
] | [
"GP:GenProp1089"
] | 1 | [
"1nbw",
"2d0o",
"2d0p"
] | 3 | [
"PUB00069745"
] | [
"21040475"
] | [
"Diol dehydratase-reactivating factor is a reactivase--evidence for multiple turnovers and subunit swapping with diol dehydratase."
] | [
2010
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Halobacteriales",
"bioreactor metagenome"
] | [
1737,
11,
4
] | 3 | [] | [] | 0 | true | Family | Diol dehydratase-reactivating factor large subunit | Diol dehydratase-reactivating factor large subunit | DDRA | 8 |
IPR009192 | 9,192 | Diol/glycerol dehydratase reactivating factor, small subunit | Diol/glycerol_deHydtase_re_ssu | Family | 997 | false | false | Diol dehydratase (propanediol dehydratase) and glycerol dehydratase undergo concomitant, irreversible inactivation by glycerol during catalysis [ , ]. This inactivation is mechanism-based and involves cleavage of the Co-C bond of the cobalamin cofactor, coenzyme B12 (AdoCbl), forming 5 -deoxyadenosine and a modified co... | [] | [] | [] | 0 | [
"PIRSF"
] | [
"PIRSF011503"
] | [
"DdrB_PduH"
] | [
997
] | 1 | [] | [] | [] | 0 | [
"1nbw",
"2d0o",
"2d0p"
] | 3 | [
"PUB00013586",
"PUB00013587",
"PUB00013588",
"PUB00013589",
"PUB00013590",
"PUB00013591",
"PUB00013592",
"PUB00013593"
] | [
"889846",
"321014",
"6752354",
"9362119",
"9405397",
"9920879",
"9023178",
"11160088"
] | [
"Study of the mechanism of action of adenosylcobalamindependent glycerol dehydratase from Aerobacter aerogenes. II. The inactivation kinetics of glycerol dehydratase complexes with adenosylobalamin and its analogs.",
"Mechanism of action of adenosylcobalamin: glycerol and other substrate analogues as substrates a... | [
1977,
1977,
1982,
1997,
1997,
1999,
1997,
2001
] | 8 | [
"IPR003208"
] | [] | 1 | 0 | 1 | [
"Bacteria",
"bioreactor metagenome"
] | [
994,
3
] | 2 | [] | [] | 0 | true | Family | Diol/glycerol dehydratase reactivating factor, small subunit | Diol/glycerol dehydratase reactivating factor, small subunit | Diol/glycerol_deHydtase_re_ssu | 6 |
IPR009193 | 9,193 | Bacterial microcompartment shell protein, EutL/PduB type | EutL_PduB | Family | 2,662 | false | false | This entry represents Bacterial microcompartment shell protein EutL/PduB predominantly found in Proteobacteria and Firmicutes. Both proteins are components of the BMC shell. EutL is involved in ethanolamine degradation [ , ], while PduB is responsible for 1,2-propanediol (1,2-PD) degradation [ , ]. Bacterial microcompa... | [
"GO:0031469"
] | [
"bacterial microcompartment"
] | [
"cellular_component"
] | 1 | [
"PIRSF"
] | [
"PIRSF012290"
] | [
"EutL_PduB"
] | [
2662
] | 1 | [] | [] | [] | 0 | [
"3gfh",
"3i82",
"3i87",
"3io0",
"3mpv",
"3u27",
"4edi",
"4fay",
"4fdz",
"4i61",
"4tlh",
"4tm6",
"4tme",
"4u6i",
"6arc",
"6ard"
] | 16 | [
"PUB00015066",
"PUB00100311",
"PUB00100312",
"PUB00100313"
] | [
"12923081",
"21239588",
"27063436",
"22428024"
] | [
"Protein content of polyhedral organelles involved in coenzyme B12-dependent degradation of 1,2-propanediol in Salmonella enterica serovar Typhimurium LT2.",
"Genetic analysis of the protein shell of the microcompartments involved in coenzyme B12-dependent 1,2-propanediol degradation by Salmonella.",
"Engineeri... | [
2003,
2011,
2016,
2012
] | 4 | [] | [
"IPR030983",
"IPR030984"
] | 0 | 2 | 0 | [
"Bacteria",
"bioreactor metagenome"
] | [
2658,
4
] | 2 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Bacterial microcompartment shell protein, EutL/PduB type | Bacterial microcompartment shell protein, EutL/PduB type | EutL_PduB | 1 |
IPR009194 | 9,194 | Corrinoid adenosyltransferase EutT | AdoTrfase_EutT | Family | 1,204 | false | false | ATP:cob(I)alamin (or ATP:corrinoid) adenosyltransferases ( ), catalyse the conversion of cobalamin (vitamin B12) into its coenzyme form, adenosylcobalamin (AdoCbl)or coenzyme B12 [ ]. AdoCbl contains an adenosyl moiety liganded to the cobalt ion of cobalamin via a covalent Co-C bond. AdoCbl is required as a cofactor fo... | [
"GO:0005524",
"GO:0008817",
"GO:0006580",
"GO:0009236"
] | [
"ATP binding",
"corrinoid adenosyltransferase activity",
"ethanolamine metabolic process",
"cobalamin biosynthetic process"
] | [
"molecular_function",
"molecular_function",
"biological_process",
"biological_process"
] | 4 | [
"NCBIFAM",
"PIRSF"
] | [
"NF011595",
"PIRSF012294"
] | [
"PRK15020.1",
"ATR_EutT"
] | [
809,
1176
] | 2 | [
"EC"
] | [
"2.5.1.154"
] | [
"EC:2.5.1.154"
] | 1 | [] | 0 | [
"PUB00013593",
"PUB00014698",
"PUB00015064",
"PUB00035323",
"PUB00035324",
"PUB00035325",
"PUB00097910"
] | [
"11160088",
"3045078",
"15317775",
"16672609",
"15516577",
"16636051",
"24336938"
] | [
"Functional genomic, biochemical, and genetic characterization of the Salmonella pduO gene, an ATP:cob(I)alamin adenosyltransferase gene.",
"Ethanolamine utilization in Salmonella typhimurium.",
"The eutT gene of Salmonella enterica Encodes an oxygen-labile, metal-containing ATP:corrinoid adenosyltransferase en... | [
2001,
1988,
2004,
2006,
2004,
2006,
2014
] | 7 | [] | [] | 0 | 0 | null | [
"Bacteria",
"bioreactor metagenome"
] | [
1202,
2
] | 2 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Corrinoid adenosyltransferase EutT | Corrinoid adenosyltransferase EutT | AdoTrfase_EutT | 1 |
IPR009198 | 9,198 | Uncharacterised conserved protein UCP014484, transmembrane | UCP014484_TM | Family | 138 | false | false | There are currently no experimental data for members of this group or their homologues. However, these proteins are predicted to contain three or more transmembrane segments. | [] | [] | [] | 0 | [
"PFAM",
"PIRSF"
] | [
"PF09973",
"PIRSF014484"
] | [
"DUF2208",
"UCP014484"
] | [
138,
32
] | 2 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Thermoproteati"
] | [
2,
136
] | 2 | [] | [] | 0 | true | Family | Uncharacterised conserved protein UCP014484, transmembrane | Uncharacterised conserved protein UCP014484, transmembrane | UCP014484_TM | 6 |
IPR009199 | 9,199 | PhoPQ-activated pathogenicity-related protein, PqaA type | PhoPQ-act_pathogen-rel_PqaA | Family | 2,635 | false | false | Proteins in this entry are believed to play a role in virulence/pathogenicity in Salmonella. Salmonella typhi PqaA has been shown to be activated by PhoP/Q two-component regulatory system, which regulates many virulence genes [ ]. It has been also shown to confer resistance to antimicrobial peptides (melittin) [ ]. Mem... | [] | [] | [] | 0 | [
"PFAM",
"PIRSF",
"PANTHER"
] | [
"PF10142",
"PIRSF014728",
"PTHR31497"
] | [
"PhoPQ_related",
"PqaA",
""
] | [
2594,
1720,
2409
] | 3 | [] | [] | [] | 0 | [] | 0 | [
"PUB00013600"
] | [
"9075219"
] | [
"PhoP/Q regulated genes in Salmonella typhi identification of melittin sensitive mutants."
] | [
1997
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
1862,
741,
32
] | 3 | [] | [] | 0 | true | Family | PhoPQ-activated pathogenicity-related protein, PqaA type | PhoPQ-activated pathogenicity-related protein, PqaA type | PhoPQ-act_pathogen-rel_PqaA | 2 |
IPR009200 | 9,200 | Protein of unknown function DUF1269, membrane associated | DUF1269_membrane | Family | 3,338 | false | false | There are currently no experimental data for members of this group or their homologues. However, these proteins are predicted to contain two or more transmembrane segments. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF06897"
] | [
"DUF1269"
] | [
3338
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Opisthokonta",
"Stenosarchaea group",
"metagenomes"
] | [
3175,
3,
137,
23
] | 4 | [] | [] | 0 | true | Family | Protein of unknown function DUF1269, membrane associated | Protein of unknown function DUF1269, membrane associated | DUF1269_membrane | 6 |
IPR009201 | 9,201 | Virion core protein, vaccinia E11L type | Virion_core | Family | 100 | false | false | This family consists of several Chordopoxvirus E11 proteins. The E11 gene of vaccinia virus encodes a 15kDa polypeptide also known as Core protein OPG073. Mutations in the E11 gene makes the virus temperature-sensitive due to either the fact that virus infectivity requires a threshold level of active E11 protein or tha... | [] | [] | [] | 0 | [
"PFAM",
"PIRSF"
] | [
"PF06138",
"PIRSF015797"
] | [
"Chordopox_E11",
"Virion_core"
] | [
100,
89
] | 2 | [] | [] | [] | 0 | [
"6rfg",
"6rfl",
"8c8h",
"8rqk",
"9fpy",
"9fq6",
"9jvu"
] | 7 | [
"PUB00013408"
] | [
"8614998"
] | [
"A temperature-sensitive mutation of the vaccinia virus E11 gene encoding a 15-kDa virion component."
] | [
1996
] | 1 | [] | [] | 0 | 0 | null | [
"Poxviridae"
] | [
100
] | 1 | [] | [] | 0 | true | Family | Virion core protein, vaccinia E11L type | Virion core protein, vaccinia E11L type | Virion_core | 2 |
IPR009203 | 9,203 | Knr4/Smi1 family | Knr4/Smi1 | Family | 1,188 | false | false | This entry includes a group of fungal proteins that are involved in cell wall biosynthesis, including Smi1 from S. cerevisiae and Cot2 from Neurospora crassa. Smi1 (also known as Knr4) is involved in the regulation of cell wall assembly and 1,3-beta-glucan synthesis, possibly through the transcriptional regulation of c... | [
"GO:0042546"
] | [
"cell wall biogenesis"
] | [
"biological_process"
] | 1 | [
"PIRSF"
] | [
"PIRSF017023"
] | [
"KNR4"
] | [
1188
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00013612",
"PUB00013613",
"PUB00044491"
] | [
"10206705",
"8289782",
"7937796"
] | [
"KNR4, a suppressor of Saccharomyces cerevisiae cwh mutants, is involved in the transcriptional control of chitin synthase genes.",
"Cloning and characterization of KNR4, a yeast gene involved in (1,3)-beta-glucan synthesis.",
"Cloning and characterization of a Neurospora crassa gene required for (1,3) beta-glu... | [
1999,
1994,
1994
] | 3 | [] | [] | 0 | 0 | null | [
"Dikarya"
] | [
1188
] | 1 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
1,
1,
1
] | 3 | true | Family | Knr4/Smi1 family | Knr4/Smi1 family | Knr4/Smi1 | 2 |
IPR009206 | 9,206 | Nucleotidase, putative | Nucleotidase_putative | Family | 1,356 | false | false | These proteins, which are annotated as putative nucleotidases, contain a domain that is distantly related to HAD-like hydrolase domain, and belong to the SCOP HAD-like hydrolase domain superfamily. | [] | [] | [] | 0 | [
"PIRSF"
] | [
"PIRSF021362"
] | [
"UCP021362_HAD"
] | [
1356
] | 1 | [
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC"... | [
"3.1.3.-",
"PWY-4702",
"PWY-5491",
"PWY-6148",
"PWY-6352",
"PWY-6365",
"PWY-6366",
"PWY-6368",
"PWY-6456",
"PWY-6575",
"PWY-6627",
"PWY-6664",
"PWY-6686",
"PWY-6720",
"PWY-6724",
"PWY-6955",
"PWY-6990",
"PWY-6991",
"PWY-7018",
"PWY-7119",
"PWY-7321",
"PWY-7531",
"PWY-7771... | [
"EC:3.1.3.-",
"METACYC:PWY-4702",
"METACYC:PWY-5491",
"METACYC:PWY-6148",
"METACYC:PWY-6352",
"METACYC:PWY-6365",
"METACYC:PWY-6366",
"METACYC:PWY-6368",
"METACYC:PWY-6456",
"METACYC:PWY-6575",
"METACYC:PWY-6627",
"METACYC:PWY-6664",
"METACYC:PWY-6686",
"METACYC:PWY-6720",
"METACYC:PWY-6... | 36 | [] | 0 | [] | [] | [] | [] | 0 | [
"IPR010708"
] | [] | 1 | 0 | 1 | [
"Bacteria",
"Phytophthora fragariae",
"metagenomes"
] | [
1348,
1,
7
] | 3 | [] | [] | 0 | true | Family | Nucleotidase, putative | Nucleotidase, putative | Nucleotidase_putative | 7 |
IPR009208 | 9,208 | Mosquitocidal toxin | Mtx2_tox | Family | 15 | false | false | This group represents a mosquitocidal toxin. | [] | [] | [] | 0 | [
"PIRSF"
] | [
"PIRSF026532"
] | [
"Mtx2_tox"
] | [
15
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [
"IPR004991"
] | [] | 1 | 0 | 1 | [
"Lysinibacillus"
] | [
15
] | 1 | [] | [] | 0 | true | Family | Mosquitocidal toxin | Mosquitocidal toxin | Mtx2_tox | 3 |
IPR009209 | 9,209 | Epsilon toxin | Epsilon_toxin | Family | 7 | false | false | This group represents an epsilon toxin [ ]. | [] | [] | [] | 0 | [
"PIRSF"
] | [
"PIRSF026587"
] | [
"Epsilon_toxin"
] | [
7
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00013641"
] | [
"1729175"
] | [
"Cloning and nucleotide sequencing of the Clostridium perfringens epsilon-toxin gene and its expression in Escherichia coli."
] | [
1992
] | 1 | [
"IPR004991"
] | [] | 1 | 0 | 1 | [
"Clostridium perfringens"
] | [
7
] | 1 | [] | [] | 0 | true | Family | Epsilon toxin | Epsilon toxin | Epsilon_toxin | 7 |
IPR009210 | 9,210 | Activating signal cointegrator 1 complex subunit 1 | ASCC1 | Family | 4,559 | false | false | ASCC1, also called ASC-1 complex subunit p50, or Trip4 complex subunit p50, is essential for DNA damage repair as component of the ASCC complex which consists of ASCC1, ASCC2 and ASCC3 subunits (p50, p100 and p200, respectively) [ , , ]. ASC-1 is also involved in ribosome assembly. The ASCC is required not only for dis... | [] | [] | [] | 0 | [
"PIRSF",
"PANTHER"
] | [
"PIRSF027019",
"PTHR13360"
] | [
"Euk_LigT",
""
] | [
1750,
4556
] | 2 | [
"REACTOME"
] | [
"R-HSA-112126"
] | [
"REACTOME:R-HSA-112126"
] | 1 | [
"8tly",
"8tuk"
] | 2 | [
"PUB00071532",
"PUB00090372",
"PUB00103503",
"PUB00103506",
"PUB00103507",
"PUB00162572",
"PUB00162573",
"PUB00162574"
] | [
"12077347",
"29144457",
"29997253",
"26924529",
"19074642",
"35180429",
"37092320",
"38366554"
] | [
"Novel transcription coactivator complex containing activating signal cointegrator 1.",
"A ubiquitin-dependent signalling axis specific for ALKBH-mediated DNA dealkylation repair.",
"RNA ligase-like domain in activating signal cointegrator 1 complex subunit 1 (ASCC1) regulates ASCC complex function during alkyl... | [
2002,
2017,
2018,
2016,
2009,
2022,
2023,
2024
] | 8 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
4559
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Schizosaccharomyces pombe (stra... | [
21,
1,
9,
1,
17,
2,
1,
7,
6,
1,
10
] | 11 | true | Family | Activating signal cointegrator 1 complex subunit 1 | Activating signal cointegrator 1 complex subunit 1 | ASCC1 | 7 |
IPR009211 | 9,211 | Type VI secretion system accessory component TagJ | TagJ | Family | 2,035 | false | false | This entry includes TagJ (also known as HsiE1), which is an accessory component of the bacterial type VI secretion system (T6SS). It plays a role in the interaction between ClpV and the TssC/TssB sheath [ ]. The type VI secretion system (T6SS), also known as CIS contractile injection system [ ], is a supra-molecular ba... | [] | [] | [] | 0 | [
"PFAM",
"PIRSF"
] | [
"PF07024",
"PIRSF029288"
] | [
"ImpE",
"SciE_ImpE"
] | [
2035,
1867
] | 2 | [] | [] | [] | 0 | [
"1zbp",
"4uqx",
"4uqy",
"4uqz"
] | 4 | [
"PUB00093972",
"PUB00093973",
"PUB00093976",
"PUB00160456"
] | [
"27288401",
"31379775",
"25305017",
"39546591"
] | [
"TssA forms a gp6-like ring attached to the type VI secretion sheath.",
"Baseplate Component TssK and Spatio-Temporal Assembly of T6SS in Pseudomonas aeruginosa.",
"Coevolution of the ATPase ClpV, the sheath proteins TssB and TssC, and the accessory protein TagJ/HsiE1 distinguishes type VI secretion classes.",
... | [
2016,
2019,
2014,
2024
] | 4 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Strongyloides venezuelensis",
"metagenomes"
] | [
2014,
1,
20
] | 3 | [] | [] | 0 | true | Family | Type VI secretion system accessory component TagJ | Type VI secretion system accessory component TagJ | TagJ | 4 |
IPR009214 | 9,214 | Protein of unknown function DUF1129 | DUF1129 | Family | 2,215 | false | false | There are currently no experimental data for members of this group or their homologues. However, these proteins contain predicted integral membrane proteins (with several transmembrane segments). | [] | [] | [] | 0 | [
"PFAM",
"PIRSF"
] | [
"PF06570",
"PIRSF033111"
] | [
"DUF1129",
"UCP033111"
] | [
2215,
1275
] | 2 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Methanorbis furvi",
"metagenomes"
] | [
2211,
1,
3
] | 3 | [] | [] | 0 | true | Family | Protein of unknown function DUF1129 | Protein of unknown function DUF1129 | DUF1129 | 9 |
IPR009215 | 9,215 | TIM-barrel domain, IGPS-like | TIM-br_IGPS-like | Domain | 4,195 | false | false | This domain is likely to have a TIM barrel fold, related to IGPS (indole-3-glycerol-phosphate synthase). Interestingly, this novel domain also exists as an N-terminal domain of a putative sigma 54 -dependent transcriptional activator. Because sigma 54 dependent activators typically have a three-domain structure: the va... | [] | [] | [] | 0 | [
"PFAM",
"PIRSF"
] | [
"PF09370",
"PIRSF034452"
] | [
"PEP_hydrolase",
"TIM-br_sig_trnsd"
] | [
4195,
2878
] | 2 | [] | [] | [] | 0 | [
"2p10"
] | 1 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
86,
2627,
1451,
31
] | 4 | [
"Arabidopsis thaliana",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
7,
1,
2,
22
] | 4 | true | Domain | TIM-barrel domain, IGPS-like | TIM-barrel domain, IGPS-like | TIM-br_IGPS-like | 2 |
IPR009218 | 9,218 | Predicted HD phosphohydrolase | HD_phosphohydro | Family | 6,382 | false | false | There are currently no experimental data for members of this group or their homologues. However, members of this family contain a version of the HDc domain (metal-dependent phosphohydrolases with conserved "HD" motif), indicating possible phosphohydrolase activity. | [] | [] | [] | 0 | [
"PIRSF",
"PANTHER"
] | [
"PIRSF035170",
"PTHR21174"
] | [
"HD_phosphohydro",
""
] | [
4442,
6382
] | 2 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Huberarchaeum crystalense",
"Viruses",
"metagenomes"
] | [
5621,
719,
1,
10,
31
] | 5 | [
"Drosophila melanogaster"
] | [
3
] | 1 | true | Family | Predicted HD phosphohydrolase | Predicted HD phosphohydrolase | HD_phosphohydro | 6 |
IPR009219 | 9,219 | Bacteriophytochrome, CheY-like | Bactrphtchr_CheY | Family | 839 | false | false | This entry contains bacteriophytochromes, or BphPs (light-regulated signal transduction histidine kinases) with the receiver (CheY-like) domain fused at the C terminus. Phytochrome dimeric photoreceptors regulate growth and development by sensing ambient light [ ]. Apart from phytochromes in photosynthetic organisms, p... | [] | [] | [] | 0 | [
"PIRSF"
] | [
"PIRSF036397"
] | [
"Bactrphtchrm_rec"
] | [
839
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00013647",
"PUB00013648",
"PUB00013649",
"PUB00013650",
"PUB00013651"
] | [
"7732376",
"10617469",
"12604773",
"11742406",
"12186972"
] | [
"Phytochromes: photosensory perception and signal transduction.",
"Bacteriophytochromes: phytochrome-like photoreceptors from nonphotosynthetic eubacteria.",
"The pair of bacteriophytochromes from Agrobacterium tumefaciens are histidine kinases with opposing photobiological properties.",
"Bacteriophytochromes... | [
1995,
1999,
2003,
2001,
2002
] | 5 | [
"IPR001294"
] | [] | 1 | 0 | 1 | [
"Pseudomonadota",
"ecological metagenomes"
] | [
836,
3
] | 2 | [] | [] | 0 | true | Family | Bacteriophytochrome, CheY-like | Bacteriophytochrome, CheY-like | Bactrphtchr_CheY | 8 |
IPR009220 | 9,220 | Probable bifunctional tRNA threonylcarbamoyladenosine biosynthesis protein | tRNA_threonyl_synthase/kinase | Family | 517 | false | false | This entry describes a probable bifunctional tRNA threonylcarbamoyladenosine biosynthesis protein. Its N-termanal domain is homologous to the Kae1/YgjD family, which is involved in tRNA threonylcarbamoyladenosine biosynthesis [ ]. Its C-terminal region contains a serine/threonine protein kinase domain (STYKS) and is ho... | [
"GO:0004222",
"GO:0008270"
] | [
"metalloendopeptidase activity",
"zinc ion binding"
] | [
"molecular_function",
"molecular_function"
] | 2 | [
"HAMAP",
"PIRSF"
] | [
"MF_01447",
"PIRSF036401"
] | [
"Kae1_Bud32_arch",
"Gcp_STYKS"
] | [
512,
453
] | 2 | [
"EC",
"EC"
] | [
"2.3.1.234",
"2.7.11.1"
] | [
"EC:2.3.1.234",
"EC:2.7.11.1"
] | 2 | [
"2vwb",
"3en9",
"3enh"
] | 3 | [
"PUB00059910",
"PUB00059911"
] | [
"21183954",
"21285948"
] | [
"The highly conserved KEOPS/EKC complex is essential for a universal tRNA modification, t6A.",
"A role for the universal Kae1/Qri7/YgjD (COG0533) family in tRNA modification."
] | [
2011,
2011
] | 2 | [] | [] | 0 | 0 | null | [
"Methanobacteriati",
"ecological metagenomes"
] | [
514,
3
] | 2 | [] | [] | 0 | true | Family | Probable bifunctional tRNA threonylcarbamoyladenosine biosynthesis protein | Probable bifunctional tRNA threonylcarbamoyladenosine biosynthesis protein | tRNA_threonyl_synthase/kinase | 6 |
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