LiteFold/InterPro · Datasets at Hugging Face

IPR010729

10,729

Large ribosomal subunit protein uL29m, mitochondrial

Ribosomal_uL29_mit

Family

4,378

false

This entry represents the eukaryotic mitochondrial ribosomal protein uL29 (also known as MRP-L47). Mitochondrial ribosomal proteins (MRPs) are the counterparts of the cytoplasmic ribosomal proteins, in that they fulfil similar functions in protein biosynthesis. However, they are distinct in number, features and primary...

[ "GO:0003735", "GO:0006412", "GO:0005761" ]

[ "structural constituent of ribosome", "translation", "mitochondrial ribosome" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PFAM", "PANTHER" ]

[ "PF06984", "PTHR21183" ]

[ "MRP-L47", "" ]

[ 4359, 4238 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-5368286", "R-HSA-5389840", "R-HSA-5419276", "R-HSA-9937383", "R-MMU-5389840", "R-MMU-5419276", "R-MMU-9937383" ]

[ "REACTOME:R-HSA-5368286", "REACTOME:R-HSA-5389840", "REACTOME:R-HSA-5419276", "REACTOME:R-HSA-9937383", "REACTOME:R-MMU-5389840", "REACTOME:R-MMU-5419276", "REACTOME:R-MMU-9937383" ]

7

[ "3j6b", "3j7y", "3j9m", "4ce4", "4v19", "5aj4", "5mrc", "5mre", "5mrf", "5ool", "5oom", "6gaw", "6gb2", "6hiv", "6hix", "6i9r", "6nu2", "6nu3", "6vlz", "6vmi", "6xyw", "6ydp", "6ydw", "6ywe", "6yws", "6ywv", "6ywx", "6ywy", "6yxx", "6yxy", "6z1p", "6zm5"...

119

[ "PUB00007068", "PUB00007069", "PUB00007070", "PUB00012961" ]

[ "11297922", "11290319", "11114498", "9445368" ]

[ "Atomic structures at last: the ribosome in 2000.", "The ribosome in focus.", "The end of the beginning: structural studies of ribosomal proteins.", "Mitochondrial ribosomal proteins (MRPs) of yeast." ]

[ 2001, 2001, 2000, 1998 ]

4

[]

0

null

[ "Eukaryota" ]

[ 4378 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 5, 2, 1, 2, 1, 1, 1, 3, 6, 1, 1, 5 ]

12

true

Family

Large ribosomal subunit protein uL29m, mitochondrial

Ribosomal_uL29_mit

1

IPR010730

10,730

Heterokaryon incompatibility

HET

Domain

77,586

false

This entry represents a conserved region approximately 150 residues long within various heterokaryon incompatibility proteins that seem to be restricted to ascomycete fungi. Genetic differences in specific het genes prevent a viable heterokaryotic fungal cell from being formed by the fusion of filaments from two differ...

[]

0

[ "PFAM" ]

[ "PF06985" ]

[ "HET" ]

[ 77586 ]

1

[]

0

[]

0

[ "PUB00012962" ]

[ "12019224" ]

[ "HET-E and HET-D belong to a new subfamily of WD40 proteins involved in vegetative incompatibility specificity in the fungus Podospora anserina." ]

[ 2002 ]

1

[]

0

null

[ "Eukaryota", "Pseudomonadota", "sediment metagenome" ]

[ 77583, 2, 1 ]

3

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)" ]

[ 65 ]

1

true

Domain

Heterokaryon incompatibility

HET

1

IPR010732

10,732

Type VI secretion, TssG-like

T6SS_TssG-like

Family

8,829

false

The bacterial Type VI secretion system (T6SS) is capable of injecting toxins into eukaryotic cells, which contributes to a successful infection [ ]. This entry represents a group of Gram-negative bacterial proteins that form part of the type VI pathogenicity secretion system (T6SS), including TssG [ ]. TssG is homologu...

[]

0

[ "PFAM", "PANTHER", "NCBIFAM" ]

[ "PF06996", "PTHR35564", "TIGR03347" ]

[ "T6SS_TssG", "", "VI_chp_1" ]

[ 8828, 8338, 7889 ]

3

[ "GP" ]

[ "GenProp0735" ]

[ "GP:GenProp0735" ]

1

[ "6giy", "6gj1", "6gj3", "6n38" ]

4

[ "PUB00011185", "PUB00075434", "PUB00077772" ]

[ "12437215", "24381728", "26460929" ]

[ "The Salmonella enterica subspecies I specific centisome 7 genomic island encodes novel protein families present in bacteria living in close contact with eukaryotic cells.", "The rise of the Type VI secretion system.", "The Type VI Secretion TssEFGK-VgrG Phage-Like Baseplate Is Recruited to the TssJLM Membrane ...

[ 2002, 2013, 2015 ]

3

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 8764, 7, 58 ]

3

[]

0

true

Family

Type VI secretion, TssG-like

T6SS_TssG-like

3

IPR010733

10,733

Domain of unknown function DUF1308

DUF1308

Domain

2,922

false

This is a domain of unknown function found on the C-terminal of C7orf25 protein UPF0415. The C-terminal domain is homologous to the known PIN-like domains. The PIN-like domain is widespread among eukaryotes, including animals, plants, and fungi, but also present in some cyanobacteria, Deinococcus, and dsDNA viruses fro...

[]

0

[ "PFAM" ]

[ "PF07000" ]

[ "DUF1308" ]

[ 2922 ]

1

[]

0

[]

0

[ "PUB00091006" ]

[ "28575517" ]

[ "Comprehensive classification of the PIN domain-like superfamily." ]

[ 2017 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "Viruses" ]

[ 30, 2862, 30 ]

3

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 5, 1, 2, 2, 2, 1, 5, 3, 7 ]

9

true

Domain

Domain of unknown function DUF1308

DUF1308

3

IPR010734

10,734

Copine, C-terminal

Copine_C

Domain

24,334

false

This represents a conserved region approximately 180 residues long within eukaryotic copines. Copines are Ca 2+ -dependent phospholipid-binding proteins that are thought to be involved in membrane-trafficking, and may also be involved in cell division and growth [ ]. They were originally identified in paramecium. They ...

[]

0

[ "PFAM", "CDD" ]

[ "PF07002", "cd01459" ]

[ "Copine", "vWA_copine_like" ]

[ 24334, 11147 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-1483206", "R-BTA-6798695", "R-CEL-9013405", "R-CEL-9013406", "R-DDI-1483206", "R-DDI-6798695", "R-DDI-9013406", "R-HSA-1483206", "R-HSA-6798695", "R-HSA-9013148", "R-HSA-9013405", "R-HSA-9013406", "R-HSA-9013409", "R-MMU-1483206", "R-MMU-6798695", "R-MMU-9013405", "R-MMU-90134...

[ "REACTOME:R-BTA-1483206", "REACTOME:R-BTA-6798695", "REACTOME:R-CEL-9013405", "REACTOME:R-CEL-9013406", "REACTOME:R-DDI-1483206", "REACTOME:R-DDI-6798695", "REACTOME:R-DDI-9013406", "REACTOME:R-HSA-1483206", "REACTOME:R-HSA-6798695", "REACTOME:R-HSA-9013148", "REACTOME:R-HSA-9013405", "REACTOM...

19

[ "6k82", "6k83", "6k85", "6k86", "6k87", "6k88", "6k89", "6k8a", "6k8b", "6kxk", "6kxu", "8hmg", "8hmh", "8xt5" ]

14

[ "PUB00012971", "PUB00057248", "PUB00081539", "PUB00081806" ]

[ "12440769", "12388743", "10830113", "9430674" ]

[ "Copines: a ubiquitous family of Ca(2+)-dependent phospholipid-binding proteins.", "Distribution and evolution of von Willebrand/integrin A domains: widely dispersed domains with roles in cell adhesion and elsewhere.", "Evolution of von Willebrand factor A (VWA) domains.", "The copines, a novel class of C2 do...

[ 2002, 2002, 1999, 1998 ]

4

[]

0

null

[ "Eukaryota", "Megaviricetes", "metagenomes" ]

[ 24321, 10, 3 ]

3

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 45, 7, 45, 29, 31, 34, 37, 84 ]

8

true

Domain

Copine, C-terminal

Copine_C

7

IPR010736

10,736

Sperm-tail PG-rich repeat

SHIPPO-rpt

Repeat

10,904

false

This entry represents a short conserved region carrying a PGP motif that is repeated in the eukaryotic sperm tail protein, outer dense fibre protein 3 (also known as Ciliary microtubule associated protein 1A) [ ]. Orthologues from some species may include up to 40 Pro-Gly-Pro repeats.

[]

0

[ "PFAM" ]

[ "PF07004" ]

[ "SHIPPO-rpt" ]

[ 10904 ]

1

[ "REACTOME" ]

[ "R-HSA-9821002" ]

[ "REACTOME:R-HSA-9821002" ]

1

[ "1o6o", "8g2z", "8g3d", "8iyj", "8otz", "8sf7", "8snb", "9cpb", "9e5c", "9e78", "9fqr" ]

11

[ "PUB00075568" ]

[ "11870087" ]

[ "Molecular cloning and characterization of a complementary DNA encoding sperm tail protein SHIPPO 1." ]

[ 2002 ]

1

[]

0

null

[ "Eukaryota", "Hymenobacter", "Methanosarcina siciliae C2J", "bird metagenome" ]

[ 10900, 2, 1, 1 ]

4

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 31, 18, 18, 19, 33 ]

5

true

Repeat

Sperm-tail PG-rich repeat

SHIPPO-rpt

7

IPR010737

10,737

Four-carbon acid sugar kinase, N-terminal domain

4-carb_acid_sugar_kinase_N

Domain

13,982

false

This conserved region is found in four-carbon acid sugar kinases from a range of Proteobacteria as well as the Gram-positive Oceanobacillus iheyensis. These four-carbon acid sugar kinases are composed of two domains: an N-terminal domain and a C-terminal domain connected by a variable linker sequence. The N-terminal do...

[]

0

[ "PFAM" ]

[ "PF07005" ]

[ "SBD_N" ]

[ 13982 ]

1

[ "EC", "METACYC", "METACYC" ]

[ "2.7.1.217", "PWY-7873", "PWY-7874" ]

[ "EC:2.7.1.217", "METACYC:PWY-7873", "METACYC:PWY-7874" ]

3

[ "1yzy", "3dqq", "4xfm", "4xfr", "4xg0", "4xgj", "5dmh" ]

7

[ "PUB00083215", "PUB00085179" ]

[ "27294475", "27402745" ]

[ "Members of a Novel Kinase Family (DUF1537) Can Recycle Toxic Intermediates into an Essential Metabolite.", "Assignment of function to a domain of unknown function: DUF1537 is a new kinase family in catabolic pathways for acid sugars." ]

[ 2016, 2016 ]

2

[]

0

null

[ "Archaea", "Bacteria", "Escherichia phage RCS47", "Eukaryota", "unclassified sequences" ]

[ 91, 12353, 1, 1434, 103 ]

5

[ "Arabidopsis thaliana", "Escherichia coli (strain K12)", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 10, 1, 3, 32 ]

4

true

Domain

Four-carbon acid sugar kinase, N-terminal domain

4-carb_acid_sugar_kinase_N

4

IPR010738

10,738

Protein of unknown function DUF1310

DUF1310

Family

848

false

This family consists of several hypothetical proteins of around 125 residues in length. Members of this family seem to be specific to Firmicutes and Actinobacteria. The function of this family is unknown.

[]

0

[ "PFAM" ]

[ "PF07006" ]

[ "DUF1310" ]

[ 848 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacillati" ]

[ 848 ]

1

[]

0

true

Family

Protein of unknown function DUF1310

DUF1310

1

IPR010740

10,740

Endomucin

Family

749

false

Endomucin, also known as sialomucin or mucin-like sialoglycoprotein, is a membrane-bound glycoprotein expressed luminally by endothelial cells that line postcapillary venules, a primary site of leukocyte recruitment during inflammation [ ]. It interferes with the assembly of focal adhesion complexes and inhibits intera...

[]

0

[ "PFAM", "PANTHER" ]

[ "PF07010", "PTHR15869" ]

[ "Endomucin", "" ]

[ 749, 730 ]

2

[]

0

[]

0

[ "PUB00019512", "PUB00078881" ]

[ "11418125", "26831939" ]

[ "Identification of human endomucin-1 and -2 as membrane-bound O-sialoglycoproteins with anti-adhesive activity.", "Endomucin prevents leukocyte-endothelial cell adhesion and has a critical role under resting and inflammatory conditions." ]

[ 2001, 2016 ]

2

[]

0

null

[ "Eukaryota" ]

[ 749 ]

1

[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 5, 3, 9 ]

3

true

Family

Endomucin

7

IPR010741

10,741

Protein of unknown function DUF1314

DUF1314

Family

68

false

This family consists of several alphaherpesvirus proteins of around 200 residues in length. Their function is unknown [ ].

[]

0

[ "PFAM" ]

[ "PF07013" ]

[ "DUF1314" ]

[ 68 ]

1

[]

0

[]

0

[ "PUB00093469" ]

[ "29056670" ]

[ "Protein Composition of the Bovine Herpesvirus 1.1 Virion." ]

[ 2017 ]

1

[]

0

null

[ "Alphaherpesvirinae" ]

[ 68 ]

1

[]

0

true

Family

Protein of unknown function DUF1314

DUF1314

8

IPR010742

10,742

Respirasome Complex Assembly Factor 1

RCAF1

Family

2,136

false

This family represents the Respirasome Complex Assembly Factor 1 (RCAF1, also known as GEL complex subunit OPTI,) a Rab5-interacting protein involved in the assembly of mitochondrial respiratory complexes [ ]. It is a component of the multi-pass translocon (MPT) complex that mediates insertion of multi-pass membrane pr...

[ "GO:0097250" ]

[ "mitochondrial respirasome assembly" ]

[ "biological_process" ]

1

[ "PANTHER" ]

[ "PTHR12906" ]

[ "" ]

[ 2136 ]

1

[ "REACTOME", "REACTOME" ]

[ "R-HSA-9864848", "R-MMU-9864848" ]

[ "REACTOME:R-HSA-9864848", "REACTOME:R-MMU-9864848" ]

2

[ "7tut" ]

1

[ "PUB00098597", "PUB00103609" ]

[ "31536960", "36261522" ]

[ "Rewiring of the Human Mitochondrial Interactome during Neuronal Reprogramming Reveals Regulators of the Respirasome and Neurogenesis.", "Substrate-driven assembly of a translocon for multipass membrane proteins." ]

[ 2019, 2022 ]

2

[ "IPR029008" ]

[]

1

0

1

[ "Eukaryota", "Odinarchaeota yellowstonii (strain LCB_4)" ]

[ 2135, 1 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 9, 1, 1, 1, 2, 1, 2, 2, 6 ]

9

true

Family

Respirasome Complex Assembly Factor 1

RCAF1

4

IPR010743

10,743

Methionine biosynthesis MetW

Methionine_synth_MetW

Family

5,451

false

This family consists of several bacterial and one archaeal methionine biosynthesis MetW proteins. Biosynthesis of methionine from homoserine in Pseudomonas putida takes place in three steps. The first step is the acylation of homoserine to yield an acyl-L-homoserine. This reaction is catalysed by the products of the me...

[]

0

[ "PFAM", "NCBIFAM" ]

[ "PF07021", "TIGR02081" ]

[ "MetW", "metW" ]

[ 5451, 5036 ]

2

[]

0

[]

0

[ "PUB00012983", "PUB00097123" ]

[ "11479715", "33604638" ]

[ "The methionine biosynthetic pathway from homoserine in Pseudomonas putida involves the metW, metX, metZ, metH and metE gene products.", "MetW regulates the enzymatic activity of MetX in Pseudomonas." ]

[ 2001, 2021 ]

2

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 39, 5240, 32, 2, 138 ]

5

[]

0

true

Family

Methionine biosynthesis MetW

Methionine_synth_MetW

9

IPR010744

10,744

Bacteriophage CI repressor, N-terminal

Phage_CI_N

Domain

3,901

false

The bacteriophage lambda cI repressor is a part of a phage molecular switch which transforms the phage from lysogenic to lytic growth. The CI repressor from Enterobacteria phage phi80 is known to function as a transcriptional switch, determining whether transcription is lytic or lysogenic [ ]. It contains two domains c...

[ "GO:0003677", "GO:0045892" ]

[ "DNA binding", "negative regulation of DNA-templated transcription" ]

[ "molecular_function", "biological_process" ]

2

[ "PFAM" ]

[ "PF07022" ]

[ "Phage_CI_repr" ]

[ 3901 ]

1

[]

0

[ "2fjr" ]

1

[ "PUB00012984", "PUB00040693", "PUB00076513" ]

[ "2370665", "16507359", "287002" ]

[ "Control of gene expression in the temperate coliphage 186. VIII. Control of lysis and lysogeny by a transcriptional switch involving face-to-face promoters.", "The structural basis of cooperative regulation at an alternate genetic switch.", "The lambda repressor contains two domains." ]

[ 1990, 2006, 1979 ]

3

[]

0

null

[ "Bacteria", "Eukaryota", "Halalkalicoccus tibetensis", "Viruses", "unclassified sequences" ]

[ 3740, 4, 1, 110, 46 ]

5

[]

0

true

Domain

Bacteriophage CI repressor, N-terminal

Phage_CI_N

7

IPR010746

10,746

Commelina yellow mottle virus, Orf1

CYMV_Orf1

Family

281

false

This entry is represented by Commelina yellow mottle virus, Orf1. The characteristics of the protein distribution suggest prophage matches in addition to the phage matches. This family contains a number of viral proteins of unknown function approximately 200 residues long. Family members seem to be restricted to badnav...

[]

0

[ "PFAM" ]

[ "PF07028" ]

[ "DUF1319" ]

[ 281 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Badnavirus", "Magnoliopsida" ]

[ 198, 83 ]

2

[]

0

true

Family

Commelina yellow mottle virus, Orf1

CYMV_Orf1

3

IPR010749

10,749

YfeC-like

Family

1,635

false

This family consists of a group of proteins predominantly found in Enterobacteria, including Uncharacterized protein YfeC from Escherichia coli, a dual transcriptional regulator predicted to form homodimers [ ].

[]

0

[ "PFAM" ]

[ "PF07037" ]

[ "YfeC-like" ]

[ 1635 ]

1

[]

0

[]

0

[ "PUB00101945" ]

[ "34428301" ]

[ "Unraveling the functions of uncharacterized transcription factors in Escherichia coli using ChIP-exo." ]

[ 2021 ]

1

[]

0

null

[ "Bacteria", "Beauveria bassiana D1-5", "human gut metagenome", "unclassified Caudoviricetes" ]

[ 1627, 1, 3, 4 ]

4

[ "Escherichia coli (strain K12)" ]

[ 2 ]

1

true

Family

YfeC-like

6

IPR010750

10,750

SGF29 tudor-like domain

SGF29_tudor-like_dom

Domain

4,672

false

SAGA-associated factor 29 (SGF29) is involved in transcriptional regulation as a chromatin reader component of some histone acetyltransferase (HAT) SAGA-type complexes like the TFTC-HAT, ATAC or STAGA complexes [ , , , , ]. SGF29 specifically recognises and binds methylated 'Lys-4' of histone H3 (H3K4me), with a prefer...

[]

0

[ "PFAM", "PROFILE" ]

[ "PF07039", "PS51518" ]

[ "SGF29_Tudor", "SGF29_C" ]

[ 4543, 4613 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-GGA-9772755", "R-HSA-3214847", "R-HSA-9772755", "R-MMU-9772755", "R-RNO-9772755" ]

[ "REACTOME:R-GGA-9772755", "REACTOME:R-HSA-3214847", "REACTOME:R-HSA-9772755", "REACTOME:R-MMU-9772755", "REACTOME:R-RNO-9772755" ]

5

[ "3lx7", "3me9", "3mea", "3met", "3meu", "3mev", "3mew", "3mp1", "3mp6", "3mp8", "5c0m" ]

11

[ "PUB00053704", "PUB00058697", "PUB00088833", "PUB00099984", "PUB00099985" ]

[ "19103755", "21685874", "20850016", "26421618", "26578293" ]

[ "The double-histone-acetyltransferase complex ATAC is essential for mammalian development.", "Sgf29 binds histone H3K4me2/3 and is required for SAGA complex recruitment and histone H3 acetylation.", "Quantitative interaction proteomics and genome-wide profiling of epigenetic histone marks and their readers.", ...

[ 2009, 2011, 2010, 2015, 2015 ]

5

[]

[ "IPR047287", "IPR047288" ]

0

2

0

[ "Eukaryota", "bird metagenome" ]

[ 4671, 1 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 21, 2, 2, 1, 2, 2, 1, 3, 7, 1, 1, 10 ]

12

true

Domain

SGF29 tudor-like domain

SGF29_tudor-like_dom

7

IPR010751

10,751

Plasmid replication initiator protein TrfA

TrfA

Family

648

false

This family consists of several bacterial TrfA proteins. The trfA operon of broad-host-range IncP plasmids is essential to activate the origin of vegetative replication in diverse species. The trfA operon encodes two ORFs. The first ORF is highly conserved and encodes a putative single-stranded DNA binding protein (Ssb...

[]

0

[ "PFAM" ]

[ "PF07042" ]

[ "TrfA" ]

[ 648 ]

1

[]

0

[]

0

[ "PUB00012987" ]

[ "8954881" ]

[ "Conservation of the genetic switch between replication and transfer genes of IncP plasmids but divergence of the replication functions which are major host-range determinants." ]

[ 1996 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "plasmids", "unclassified sequences", "uncultured Caudovirales phage" ]

[ 622, 4, 14, 7, 1 ]

5

[]

0

true

Family

Plasmid replication initiator protein TrfA

TrfA

8

IPR010753

10,753

Domain of unknown function DUF1330

DUF1330

Domain

12,618

false

This family consists of several hypothetical bacterial proteins of around 90 residues in length. The function of this family is unknown.

[]

0

[ "PFAM" ]

[ "PF07045" ]

[ "DUF1330" ]

[ 12618 ]

1

[]

0

[ "2fiu", "3dca", "3hhl", "3lo3" ]

4

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Stenosarchaea group", "unclassified sequences" ]

[ 12218, 95, 26, 279 ]

4

[]

0

true

Domain

Domain of unknown function DUF1330

DUF1330

9

IPR010754

10,754

Optic atrophy 3-like

OPA3-like

Family

4,888

false

OPA3 deficiency causes type III 3-methylglutaconic aciduria (MGA) in humans. This disease manifests with early bilateral optic atrophy, spasticity, extrapyramidal dysfunction, ataxia, and cognitive deficits, but normal longevity [ ]. This family consists of several optic atrophy 3 (OPA3) proteins and related proteins f...

[]

0

[ "PFAM", "PANTHER" ]

[ "PF07047", "PTHR12499" ]

[ "OPA3", "" ]

[ 4874, 4692 ]

2

[]

0

[]

0

[ "PUB00012988" ]

[ "12126933" ]

[ "3-Methylglutaconic aciduria type III in a non-Iraqi-Jewish kindred: clinical and molecular findings." ]

[ 2002 ]

1

[]

0

null

[ "Eukaryota" ]

[ 4888 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Schizosaccharomyces pombe (stra...

[ 9, 3, 1, 4, 2, 2, 1, 12, 2, 1, 9 ]

11

true

Family

Optic atrophy 3-like

OPA3-like

1

IPR010756

10,756

Telomere length and silencing protein 1-like

Tls1-like

Family

3,991

false

Tls1 in fission yeast is required for telomeric heterochromatin assembly as well as telomere length control [ , ]. The human homologue, the splicing factor C9orf78 (also known as hepatocellular carcinoma-associated antigen 59), plays a role in pre-mRNA splicing by promoting usage of the upstream 3'-splice site at alter...

[]

0

[ "PFAM", "PANTHER" ]

[ "PF07052", "PTHR13486" ]

[ "Hep_59", "" ]

[ 3910, 3800 ]

2

[ "REACTOME", "REACTOME" ]

[ "R-HSA-72163", "R-MMU-72163" ]

[ "REACTOME:R-HSA-72163", "REACTOME:R-MMU-72163" ]

2

[ "7os2", "8c6j", "9fmd" ]

3

[ "PUB00072803", "PUB00086882", "PUB00101899", "PUB00101900", "PUB00101901", "PUB00101902" ]

[ "12097419", "25245948", "35167828", "35241646", "36095128", "3524164" ]

[ "Large scale identification of human hepatocellular carcinoma-associated antigens by autoantibodies.", "Tls1 regulates splicing of shelterin components to control telomeric heterochromatin assembly and telomere length.", "C9ORF78 partially localizes to centromeres and plays a role in chromosome segregation.", ...

[ 2002, 2014, 2022, 2022, 2022, 1986 ]

6

[]

0

null

[ "Eukaryota" ]

[ 3991 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Schizosaccharomyces pombe (stra...

[ 3, 1, 1, 1, 3, 1, 1, 2, 4, 1, 2 ]

11

true

Family

Telomere length and silencing protein 1-like

Tls1-like

6

IPR010758

10,758

Trans-2-enoyl-CoA reductase

Trans-2-enoyl-CoA_reductase

Family

4,707

false

This entry represents trans-2-enoyl-CoA reductase which catalyses reduction of enoyl-CoA to acyl-CoA, an important step of fatty acid biosynthesis which is performed under anaerobiosis [ ]. This entry also includes triclosan-resistant enoyl-acyl carrier protein reductase, such as FabV from Pseudomonas aeruginosa [ ] an...

[ "GO:0016491" ]

[ "oxidoreductase activity" ]

[ "molecular_function" ]

1

[ "HAMAP", "NCBIFAM", "NCBIFAM", "PANTHER" ]

[ "MF_01838", "NF010177", "NF043048", "PTHR37480" ]

[ "FabV_reductase", "PRK13656.1", "EnoyACPredFabV", "" ]

[ 4222, 4559, 4362, 4707 ]

4

[ "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC" ]

[ "1.3.1.9", "PWY-5971", "PWY-5973", "PWY-5989", "PWY-6282", "PWY-6519", "PWY-7663", "PWY-7664", "PWY-7858", "PWY-8173", "PWY-8174", "PWY-8175", "PWY-8203", "PWYG-321" ]

[ "EC:1.3.1.9", "METACYC:PWY-5971", "METACYC:PWY-5973", "METACYC:PWY-5989", "METACYC:PWY-6282", "METACYC:PWY-6519", "METACYC:PWY-7663", "METACYC:PWY-7664", "METACYC:PWY-7858", "METACYC:PWY-8173", "METACYC:PWY-8174", "METACYC:PWY-8175", "METACYC:PWY-8203", "METACYC:PWYG-321" ]

14

[ "3s8m", "3zu2", "3zu3", "3zu4", "3zu5", "4bko", "4bkq", "4bkr", "4eue", "4euf", "4euh", "4fbg", "4ggo", "4ggp", "5g2o", "5jai", "5jam", "5jaq", "5xi0", "8rcz" ]

20

[ "PUB00056785", "PUB00071247", "PUB00099582", "PUB00104903", "PUB00104904", "PUB00104905" ]

[ "15569691", "19933806", "25370725", "17382934", "18032386", "20055482" ]

[ "Mitochondrial trans-2-enoyl-CoA reductase of wax ester fermentation from Euglena gracilis defines a new family of enzymes involved in lipid synthesis.", "Triclosan resistance of Pseudomonas aeruginosa PAO1 is due to FabV, a triclosan-resistant enoyl-acyl carrier protein reductase.", "Triclosan Resistance in a ...

[ 2005, 2010, 2015, 2007, 2008, 2010 ]

6

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 4643, 21, 43 ]

3

[]

0

true

Family

Trans-2-enoyl-CoA reductase

Trans-2-enoyl-CoA_reductase

9

IPR010760

10,760

DNA repair protein, Swi5

DNA-repair_Swi5

Family

2,409

false

This entry represents Swi5 and is involved in meiotic DNA repair synthesis and meiotic joint molecule formation [ , ]. It is known to interact with Swi2, Rhp51 and Swi6 [ ].

[]

0

[ "PFAM", "PANTHER" ]

[ "PF07061", "PTHR28529" ]

[ "Swi5", "" ]

[ 2404, 2138 ]

2

[]

0

[ "3viq", "3vir" ]

2

[ "PUB00019450", "PUB00090451" ]

[ "14663140", "21252223" ]

[ "Two different Swi5-containing protein complexes are involved in mating-type switching and recombination repair in fission yeast.", "The role of the human SWI5-MEI5 complex in homologous recombination repair." ]

[ 2003, 2011 ]

2

[]

0

null

[ "Candidatus Uhriibacteriota", "Eukaryota", "viral metagenome" ]

[ 3, 2405, 1 ]

3

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 3, 8, 4, 1, 5, 1, 1 ]

8

true

Family

DNA repair protein, Swi5

DNA-repair_Swi5

7

IPR010761

10,761

Clc protein-like

Clc_prot-like

Family

1,074

false

Clc proteins are a nine-member gene family of chloride channels that have diverse roles in the plasma membrane and in intracellular organelles, especially membrane excitability and the maintenance of osmotic balance [ , ]. These proteins have been widely related with a variety of human diseases ranging from degeneratio...

[ "GO:0016020" ]

[ "membrane" ]

[ "cellular_component" ]

1

[ "PFAM" ]

[ "PF07062" ]

[ "Clc-like" ]

[ 1074 ]

1

[]

0

[]

0

[ "PUB00044604", "PUB00044605", "PUB00099802", "PUB00099803" ]

[ "16596447", "12512775", "25443653", "28534947" ]

[ "Inhibition of ClC-2 chloride channels by a peptide component or components of scorpion venom.", "Mechanisms of block of muscle type CLC chloride channels (Review).", "ClC-5: Physiological role and biophysical mechanisms.", "Research and progress on ClC‑2 (Review)." ]

[ 2005, 2002, 2015, 2017 ]

4

[]

0

null

[ "Bilateria" ]

[ 1074 ]

1

[ "Caenorhabditis elegans" ]

[ 13 ]

1

true

Family

Clc protein-like

Clc_prot-like

9

IPR010762

10,762

Capsid protein, T4-like bacteriophage-like

Gp23/Gp24_T4-like

Family

3,074

false

This family contains a number of capsid Gp23 and Gp24 proteins approximately 500 residues long, mainly from T4-like bacteriophages. Bacteriophage T4 Gp24 is a capsid protein that self-associates to form 11 pentons, building the T=13 laevo capsid in association with 160 hexamers of gp23* and one dodecamer of gp20 [ ].

[]

0

[ "PFAM" ]

[ "PF07068" ]

[ "Gp23" ]

[ 3074 ]

1

[]

0

[ "1yue", "5vf3", "6uzc", "7vrt", "7vs5", "8gmo", "8t1x", "8t9r" ]

8

[ "PUB00074276" ]

[ "15071181" ]

[ "Molecular architecture of the prolate head of bacteriophage T4." ]

[ 2004 ]

1

[]

[ "IPR038997", "IPR038999" ]

0

2

0

[ "Archaea", "Bacteria", "Ecdysozoa", "Viruses", "metagenomes" ]

[ 4, 24, 3, 2979, 64 ]

5

[]

0

true

Family

Capsid protein, T4-like bacteriophage-like

Gp23/Gp24_T4-like

3

IPR010763

10,763

2-dehydro-3-deoxy-phosphogluconate aldolase

DgaF

Family

2,783

false

DgaF is part of the dga operon required for wild-type growth of Salmonella Typhimurium with D-glucosaminate. It catalyses the conversion of keto-3-deoxygluconate 6-phosphate (KDGP) to yield pyruvate and glyceraldehyde-3-phosphate. Orthologs of the dga genes are largely restricted to certain enteric bacteria and a few s...

[]

0

[ "PFAM", "NCBIFAM" ]

[ "PF07071", "TIGR03581" ]

[ "KDGP_aldolase", "EF_0839" ]

[ 2783, 2617 ]

2

[ "GP" ]

[ "GenProp0798" ]

[ "GP:GenProp0798" ]

1

[ "3lm7", "3m0z", "3m6y", "3mux", "3n73", "3nzr" ]

6

[ "PUB00075650" ]

[ "23836865" ]

[ "Salmonella utilizes D-glucosaminate via a mannose family phosphotransferase system permease and associated enzymes." ]

[ 2013 ]

1

[]

0

null

[ "Bacteria", "Phytophthora", "ecological metagenomes" ]

[ 2778, 2, 3 ]

3

[]

0

true

Family

2-dehydro-3-deoxy-phosphogluconate aldolase

DgaF

8

IPR010764

10,764

Protein of unknown function DUF1347

DUF1347

Family

33

false

This family consists of several hypothetical bacterial proteins of around 610 residues in length. Members of this family are highly conserved and seem to be specific to Chlamydia species. The function of this family is unknown.

[]

0

[ "PFAM", "PIRSF" ]

[ "PF07079", "PIRSF009431" ]

[ "DUF1347", "DUF1347" ]

[ 33, 22 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Chlamydiia" ]

[ 33 ]

1

[]

0

true

Family

Protein of unknown function DUF1347

DUF1347

5

IPR010766

10,766

DRTGG

Domain

15,084

false

This presumed domain is about 120 amino acids in length. It is found associated with CBS domains , as well as the CbiA domain . The function of this domain is unknown. It is named the DRTGG domain after some of the most conserved residues. This domain may be very distantly related to a pair of CBS domains. There are no...

[]

0

[ "PFAM" ]

[ "PF07085" ]

[ "DRTGG" ]

[ 15084 ]

1

[ "EC", "GP", "GP", "GP", "GP", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC" ]

[ "2.3.1.8", "GenProp1267", "GenProp1345", "GenProp1543", "GenProp1749", "PWY-1281", "PWY-5482", "PWY-5485", "PWY-5497", "PWY-6637", "PWY-8086", "PWY-8377" ]

[ "EC:2.3.1.8", "GP:GenProp1267", "GP:GenProp1345", "GP:GenProp1543", "GP:GenProp1749", "METACYC:PWY-1281", "METACYC:PWY-5482", "METACYC:PWY-5485", "METACYC:PWY-5497", "METACYC:PWY-6637", "METACYC:PWY-8086", "METACYC:PWY-8377" ]

12

[ "2ioj", "3l2b", "3l31" ]

3

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 433, 14209, 281, 161 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Domain

DRTGG

6

IPR010767

10,767

Campylobacter phage CGC-2007, Cje0229

Phage_CGC-2007_Cje0229

Family

2,398

false

This entry is represented by Campylobacter phage CGC-2007, Cje0229. The characteristics of the protein distribution suggest prophage matches in addition to the phage matches. This family consists of several hypothetical phage and bacterial proteins of around 100 residues in length. The function of this family is unknow...

[]

0

[ "PFAM" ]

[ "PF07087" ]

[ "DUF1353" ]

[ 2398 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Palpitomonas bilix", "Viruses", "metagenomes" ]

[ 2193, 1, 102, 102 ]

4

[]

0

true

Family

Campylobacter phage CGC-2007, Cje0229

Phage_CGC-2007_Cje0229

7

IPR010768

10,768

Putative glutamine amidotransferase

GATase1-like

Domain

3,314

false

This domain can be found in several hypothetical bacterial proteins of around 250 residues in length. The function of this domain is unknown. The structure of this cytoplasmic domain was solved by the Midwest Center for Structural Genomics (MCSG). The structure has been classified as part of the Class-I Glutamine amido...

[]

0

[ "PFAM" ]

[ "PF07090" ]

[ "GATase1_like" ]

[ 3314 ]

1

[]

0

[ "2gk3", "3rht", "3soz" ]

3

[ "PUB00075436" ]

[ "17968677" ]

[ "Novel hexamerization motif is discovered in a conserved cytoplasmic protein from Salmonella typhimurium." ]

[ 2007 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "ecological metagenomes" ]

[ 24, 3237, 4, 49 ]

4

[]

0

true

Domain

Putative glutamine amidotransferase

GATase1-like

4

IPR010769

10,769

Ribosomal RNA aminoglycoside-resistance methyltransferase, Gram-negative bacteria

rRNA_MeTrfase_GmN_bac

Family

237

false

This family consists of several ribosomal RNA methyltransferases from Gram-negative bacteria involved in aminoglycoside-resistance [ , , ].

[ "GO:0008649", "GO:0046677" ]

[ "rRNA methyltransferase activity", "response to antibiotic" ]

[ "molecular_function", "biological_process" ]

2

[ "PIRSF" ]

[ "PIRSF015852" ]

[ "RRNA_mtase_Grm" ]

[ 237 ]

1

[ "EC" ]

[ "2.1.1.179" ]

[ "EC:2.1.1.179" ]

1

[ "3b89", "3frh", "3fri", "3lcu", "3lcv", "6cn0", "6pi9", "6pqb", "8ghu" ]

9

[ "PUB00013443", "PUB00013444", "PUB00059175" ]

[ "8486289", "2013410", "19589804" ]

[ "Analysis of the self-defense gene (fmrO) of a fortimicin A (astromicin) producer, Micromonospora olivasterospora: comparison with other aminoglycoside-resistance-encoding genes.", "Cloning and characterization of gentamicin-resistance genes from Micromonospora purpurea and Micromonospora rosea.", "Determinatio...

[ 1993, 1991, 2009 ]

3

[ "IPR025981" ]

[]

1

0

1

[ "Bacteria", "hydrothermal vent metagenome" ]

[ 235, 2 ]

2

[]

0

true

Family

Ribosomal RNA aminoglycoside-resistance methyltransferase, Gram-negative bacteria

rRNA_MeTrfase_GmN_bac

4

IPR010770

10,770

Ecd family

Ecd

Family

4,335

false

This entry represents Ecd (ecdysoneless) family. Drosophila ecd mutants display reduced steroid titers during larval development [ ]. Mammalian Ecd (also known as SGT1 and hEcd in humans) has been shown to stimulate cell proliferation by interacting with the Retinoblastoma (Rb) proteins [ ]. Ecd proteins may be involve...

[]

0

[ "PFAM", "PANTHER" ]

[ "PF07093", "PTHR13060" ]

[ "SGT1", "" ]

[ 4232, 4260 ]

2

[]

0

[]

0

[ "PUB00075623", "PUB00075624", "PUB00075626", "PUB00075627", "PUB00075628" ]

[ "16592466", "19640839", "24722212", "22270930", "22977192" ]

[ "Roles of ecdysone in Drosophila development.", "Role of mammalian Ecdysoneless in cell cycle regulation.", "Unexpected role of the steroid-deficiency protein ecdysoneless in pre-mRNA splicing.", "Overexpression of a novel cell cycle regulator ecdysoneless in breast cancer: a marker of poor prognosis in HER2/...

[ 1977, 2009, 2014, 2012, 2012 ]

5

[]

0

null

[ "Eukaryota" ]

[ 4335 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Schizosaccharomyces pombe (stra...

[ 5, 1, 3, 1, 7, 4, 1, 2, 3, 1, 3 ]

11

true

Family

Ecd family

Ecd

4

IPR010771

10,771

Intracellular growth attenuator IgaA

IgaA

Family

1,785

false

This family consists of several bacterial intracellular growth attenuator (IgaA) proteins. IgaA is involved in negative control of bacterial proliferation within fibroblasts. IgaA is homologous to the Escherichia coli YrfF and Proteus mirabilis UmoB proteins. Whereas the biological function of YrfF is currently unknown...

[ "GO:0016020" ]

[ "membrane" ]

[ "cellular_component" ]

1

[ "PFAM" ]

[ "PF07095" ]

[ "IgaA" ]

[ 1785 ]

1

[]

0

[ "4uzm", "9biy", "9biz", "9bj0" ]

4

[ "PUB00013000" ]

[ "11553591" ]

[ "Salmonella enterica serovar Typhimurium response involved in attenuation of pathogen intracellular proliferation." ]

[ 2001 ]

1

[]

0

null

[ "Bacteria", "Dickeya phage phiDP23.1", "Eukaryota", "unclassified sequences" ]

[ 1776, 1, 2, 6 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Intracellular growth attenuator IgaA

IgaA

9

IPR010772

10,772

Protein of unknown function DUF1359

DUF1359

Family

27

false

This family consists of several hypothetical bacterial and phage proteins of around 100 residues in length. Members of this family seem to be found exclusively in Lactococcus lactis and the bacteriophages that infect this species. The function of this family is unknown.

[]

0

[ "PFAM" ]

[ "PF07097" ]

[ "DUF1359" ]

[ 27 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Anaeramoeba ignava", "Lactococcus" ]

[ 1, 26 ]

2

[]

0

true

Family

Protein of unknown function DUF1359

DUF1359

1

IPR010774

10,774

Putative nuclease YbcO

YbcO

Family

1,323

false

This entry includes YbcO ( ), a putative nuclease from E. coli [ ]. Proteins in the entry have been predicted to have the His-Me finger nuclease domain and may act as a recombinase that participates in DNA repair and replication [ ].

[]

0

[ "PFAM" ]

[ "PF07102" ]

[ "YbcO" ]

[ 1323 ]

1

[]

0

[ "3g27" ]

1

[ "PUB00097591", "PUB00097596" ]

[ "29040665", "27562564" ]

[ "Systematic classification of the His-Me finger superfamily.", "Classification of the treble clef zinc finger: noteworthy lessons for structure and function evolution." ]

[ 2017, 2016 ]

2

[]

0

null

[ "Bacteria", "Cyprideis torosa", "Thermoproteota archaeon", "Viruses", "metagenomes" ]

[ 1255, 1, 1, 61, 5 ]

5

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Putative nuclease YbcO

YbcO

7

IPR010775

10,775

Protein of unknown function DUF1365

DUF1365

Family

8,785

false

This family consists of several bacterial and plant proteins of around 250 residues in length. The function of this family is unknown.

[]

0

[ "PFAM", "PANTHER" ]

[ "PF07103", "PTHR33973" ]

[ "DUF1365", "" ]

[ 8770, 8501 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Yasminevirus sp. GU-2018", "unclassified Candidatus Thermoprofundales", "unclassified sequences" ]

[ 6671, 2050, 1, 4, 59 ]

5

[ "Arabidopsis thaliana", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 5, 1, 3, 4 ]

4

true

Family

Protein of unknown function DUF1365

DUF1365

8

IPR010776

10,776

Homologous-pairing protein 2, winged helix domain

Hop2_WH_dom

Domain

3,090

false

Homologous-pairing protein 2 (Hop2) is required for proper homologous pairing and efficient cross-over and intragenic recombination during meiosis [ , , ]. The mammalian HOP2 homologue, TBPIP, was first identified as a factor interacting with TBP-1, which binds to the human immunodeficiency virus, type 1 Tat protein [ ...

[]

0

[ "PFAM" ]

[ "PF07106" ]

[ "WHD_TBPIP" ]

[ 3090 ]

1

[ "REACTOME" ]

[ "R-HSA-912446" ]

[ "REACTOME:R-HSA-912446" ]

1

[ "2mh2", "4y66" ]

2

[ "PUB00084330", "PUB00084331", "PUB00084332", "PUB00084333" ]

[ "9708739", "11447128", "15192114", "9345291" ]

[ "The meiosis-specific Hop2 protein of S. cerevisiae ensures synapsis between homologous chromosomes.", "A novel meiosis-specific protein of fission yeast, Meu13p, promotes homologous pairing independently of homologous recombination.", "Positive role of the mammalian TBPIP/HOP2 protein in DMC1-mediated homologo...

[ 1998, 2001, 2004, 1997 ]

4

[]

0

null

[ "Bacteria", "Eukaryota", "Methanomicrobiales", "ecological metagenomes" ]

[ 43, 3038, 6, 3 ]

4

[ "Arabidopsis thaliana", "Danio rerio", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)", "Zea mays" ]

[ 2, 1, 5, 3, 3, 3, 1, 1, 5 ]

9

true

Domain

Homologous-pairing protein 2, winged helix domain

Hop2_WH_dom

2

IPR010777

10,777

PipA

Family

1,208

false

This family consists of several Salmonella PipA (pathogenicity island-encoded protein A) and related phage sequences. PipA is thought to contribute to enteric but not to systemic salmonellosis [ ]. The family carries a highly conserved HEXXH sequence motif along with several highly conserved glutamic acid residues whic...

[]

0

[ "PFAM" ]

[ "PF07108" ]

[ "PipA" ]

[ 1208 ]

1

[]

0

[ "6ggo", "6ggr" ]

2

[ "PUB00013003" ]

[ "9723926" ]

[ "Identification of a pathogenicity island required for Salmonella enteropathogenicity." ]

[ 1998 ]

1

[]

0

null

[ "Pseudomonadota", "Zophobas morio", "unclassified bacterial viruses" ]

[ 1197, 9, 2 ]

3

[]

0

true

Family

PipA

2

IPR010779

10,779

Protein of unknown function DUF1372

DUF1372

Family

332

false

This family consists of several Streptococcus bacteriophage sequences and related proteins from Streptococcus species. Members of this family are typically around 100 residues in length and their function is unknown.

[]

0

[ "PFAM" ]

[ "PF07116" ]

[ "DUF1372" ]

[ 332 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Viruses" ]

[ 169, 163 ]

2

[]

0

true

Family

Protein of unknown function DUF1372

DUF1372

2

IPR010780

10,780

Protein of unknown function DUF1375

DUF1375

Family

4,070

false

This family consists of several hypothetical, putative lipoproteins of around 80 residues in length. Members of this family seem to be specific to the class Gammaproteobacteria. The function of this family is unknown.

[]

0

[ "PFAM" ]

[ "PF07119" ]

[ "DUF1375" ]

[ 4070 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Opisthokonta", "ecological metagenomes" ]

[ 4064, 3, 3 ]

3

[ "Escherichia coli (strain K12)" ]

[ 2 ]

1

true

Family

Protein of unknown function DUF1375

DUF1375

2

IPR010781

10,781

Protein of unknown function DUF1376

DUF1376

Family

1,586

false

This entry includes Bacteriophage PBC5 (Sinorhizobium phage PBC5), Orf49. The characteristics of the protein distribution suggest prophage matches in addition to the phage matches. This family consists of several hypothetical bacterial proteins of around 95 residues in length. The function of this family is unknown.

[]

0

[ "PFAM" ]

[ "PF07120" ]

[ "DUF1376" ]

[ 1586 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Mycena chlorophos", "Viruses", "metagenomes" ]

[ 1471, 1, 90, 24 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Protein of unknown function DUF1376

DUF1376

4

IPR010784

10,784

Merozoite surface protein-type

Merozoite_SPAM

Family

918

false

This entry consists of several Plasmodium falciparum SPAM (secreted polymorphic antigen associated with merozoites) proteins, also know as merozoite surface proteins. Variation among SPAM alleles is the result of deletions and amino acid substitutions in non-repetitive sequences within and flanking the alanine heptad-r...

[]

0

[ "PFAM" ]

[ "PF07133" ]

[ "Merozoite_SPAM" ]

[ 918 ]

1

[]

0

[ "7y09" ]

1

[ "PUB00013445", "PUB00013446" ]

[ "7891748", "7893643" ]

[ "Molecular variation in a novel polymorphic antigen associated with Plasmodium falciparum merozoites.", "Solution structure of a polypeptide containing four heptad repeat units from a merozoite surface antigen of Plasmodium falciparum." ]

[ 1994, 1995 ]

2

[]

0

null

[ "Eukaryota" ]

[ 918 ]

1

[]

0

true

Family

Merozoite surface protein-type

Merozoite_SPAM

9

IPR010785

10,785

Autographa californica nuclear polyhedrosis virus (AcMNPV), Protein AC18

AcMNPV_AC18

Family

124

false

This entry represents Protein AC18 from Autographa californica nuclear polyhedrosis virus (AcMNPV) and similar proteins from the viral family Baculoviridae. AC18 may play a role in occlusion-derived virions (ODV) formation and/or regulation of late viral gene expression [ ]. It interacts with the protein FP25, which is...

[]

0

[ "PFAM" ]

[ "PF07134" ]

[ "AcMNPV_Orf18" ]

[ 124 ]

1

[]

0

[]

0

[ "PUB00082301", "PUB00099997" ]

[ "17573091", "27147751" ]

[ "ac18 is not essential for the propagation of Autographa californica multiple nucleopolyhedrovirus.", "Functional Regulation of an Autographa californica Nucleopolyhedrovirus-Encoded MicroRNA, AcMNPV-miR-1, in Baculovirus Replication." ]

[ 2007, 2016 ]

2

[]

0

null

[ "Viruses" ]

[ 124 ]

1

[]

0

true

Family

Autographa californica nuclear polyhedrosis virus (AcMNPV), Protein AC18

AcMNPV_AC18

3

IPR010787

10,787

Protein of unknown function DUF1385

DUF1385

Family

3,776

false

This family represents Uncharacterized protein YqhQ from Bacillus subtilis and related hypothetical bacterial proteins of unknown function. Some family members are predicted to be metal-dependent.

[]

0

[ "PFAM" ]

[ "PF07136" ]

[ "DUF1385" ]

[ 3776 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Caudoviricetes", "Eukaryota", "unclassified sequences" ]

[ 2, 3609, 3, 9, 153 ]

5

[]

0

true

Family

Protein of unknown function DUF1385

DUF1385

1

IPR010788

10,788

VDE lipocalin domain

VDE_dom

Domain

1,754

false

This entry represents the conserved lipocalin domain within plant violaxanthin de-epoxidase (VDE), which is thought to bind xanthophyll molecules in all-trans configuration. In higher plants, violaxanthin de-epoxidase forms part of a conserved system that dissipates excess energy as heat in the light-harvesting complex...

[ "GO:0046422" ]

[ "violaxanthin de-epoxidase activity" ]

[ "molecular_function" ]

1

[ "PFAM" ]

[ "PF07137" ]

[ "VDE" ]

[ 1754 ]

1

[ "EC", "GP" ]

[ "1.23.5.1", "GenProp1508" ]

[ "EC:1.23.5.1", "GP:GenProp1508" ]

2

[ "3cqn", "3cqr" ]

2

[ "PUB00013012", "PUB00096786" ]

[ "8692813", "23717606" ]

[ "Molecular cloning of violaxanthin de-epoxidase from romaine lettuce and expression in Escherichia coli.", "Molecular cloning and characterization of violaxanthin de-epoxidase (CsVDE) in cucumber." ]

[ 1996, 2013 ]

2

[]

0

null

[ "Eukaryota" ]

[ 1754 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 15, 10, 5 ]

3

true

Domain

VDE lipocalin domain

VDE_dom

4

IPR010789

10,789

Terminase small subunit, Skunalikevirus-type

Terminase_ssu_Skunalikevirus

Family

199

false

This family consists of several putative Lactococcus bacteriophage terminase small subunit proteins [ ]. The exact function of this family is unknown.

[]

0

[ "PFAM" ]

[ "PF07141" ]

[ "Phage_term_sma" ]

[ 199 ]

1

[ "GP" ]

[ "GenProp0208" ]

[ "GP:GenProp0208" ]

1

[]

0

[ "PUB00082566" ]

[ "24027307" ]

[ "Structure, adsorption to host, and infection mechanism of virulent lactococcal phage p2." ]

[ 2013 ]

1

[]

0

null

[ "Bacteria", "Caudoviricetes" ]

[ 21, 178 ]

2

[]

0

true

Family

Terminase small subunit, Skunalikevirus-type

Terminase_ssu_Skunalikevirus

2

IPR010791

10,791

AttH domain

AttH_dom

Domain

4,789

false

This domain is found in bacterial and fungal proteins that contain the AttH-like fold characterised by two flattened, orthogonally packed, β-barrels of lipocalin-like topology. Proteins containing this domain include (also known as NE1406), an all-β protein with an AttH-like fold [ , ].

[]

0

[ "PFAM" ]

[ "PF07143" ]

[ "CrtC" ]

[ 4789 ]

1

[]

0

[ "2ich", "7a0q", "7a0t" ]

3

[ "PUB00055863", "PUB00075383", "PUB00078043", "PUB00078044" ]

[ "20944205", "7655061", "8752352", "3025176" ]

[ "Structure of the first representative of Pfam family PF09410 (DUF2006) reveals a structural signature of the calycin superfamily that suggests a role in lipid metabolism.", "The Fusarium solani gene encoding kievitone hydratase, a secreted enzyme that catalyzes detoxification of a bean phytoalexin.", "Requirem...

[ 2010, 1995, 1996, 1987 ]

4

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 22, 4424, 308, 35 ]

4

[]

0

true

Domain

AttH domain

AttH_dom

5

IPR010792

10,792

Protein of unknown function DUF1389

DUF1389

Family

103

false

This family consists of several hypothetical bacterial proteins, which seem to be specific to Chlamydiia. Members of this family are typically around 400 residues in length. The function of this family is unknown.

[]

0

[ "PFAM" ]

[ "PF07146" ]

[ "DUF1389" ]

[ 103 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Chlamydia" ]

[ 103 ]

1

[]

0

true

Family

Protein of unknown function DUF1389

DUF1389

5

IPR010793

10,793

Large ribosomal subunit protein mL37/mL65

Ribosomal_mL37/mL65

Family

2,871

false

This entry consists of several eukaryotic mitochondrial 28S ribosomal protein mL65 (previously known as mitochondrial ribosomal protein MRPS30 and programmed cell death protein 9 PDCD9). The exact function is unknown although it is known to be a component of the mitochondrial ribosome and a component in cellular apopto...

[ "GO:0003735", "GO:0006412", "GO:0005739", "GO:0005840" ]

[ "structural constituent of ribosome", "translation", "mitochondrion", "ribosome" ]

[ "molecular_function", "biological_process", "cellular_component", "cellular_component" ]

4

[ "PFAM" ]

[ "PF07147" ]

[ "PDCD9" ]

[ 2871 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-5389840", "R-BTA-5419276", "R-BTA-9937383", "R-HSA-5368286", "R-HSA-5389840", "R-HSA-5419276", "R-HSA-9937383", "R-MMU-5389840", "R-MMU-5419276", "R-MMU-9937383", "R-RNO-5389840", "R-RNO-5419276", "R-RNO-9937383" ]

[ "REACTOME:R-BTA-5389840", "REACTOME:R-BTA-5419276", "REACTOME:R-BTA-9937383", "REACTOME:R-HSA-5368286", "REACTOME:R-HSA-5389840", "REACTOME:R-HSA-5419276", "REACTOME:R-HSA-9937383", "REACTOME:R-MMU-5389840", "REACTOME:R-MMU-5419276", "REACTOME:R-MMU-9937383", "REACTOME:R-RNO-5389840", "REACTOM...

13

[ "3j7y", "3j9m", "4v1a", "5aj4", "5ool", "5oom", "6gaw", "6gb2", "6i9r", "6nu2", "6nu3", "6vlz", "6vmi", "6ydp", "6ydw", "6zm5", "6zm6", "6zs9", "6zsa", "6zsb", "6zsc", "6zsd", "6zse", "6zsg", "7a5f", "7a5g", "7a5h", "7a5i", "7a5j", "7a5k", "7l08", "7l20"...

91

[ "PUB00007068", "PUB00007069", "PUB00007070", "PUB00013016" ]

[ "11297922", "11290319", "11114498", "11248257" ]

[ "Atomic structures at last: the ribosome in 2000.", "The ribosome in focus.", "The end of the beginning: structural studies of ribosomal proteins.", "A new face on apoptosis: death-associated protein 3 and PDCD9 are mitochondrial ribosomal proteins." ]

[ 2001, 2001, 2000, 2001 ]

4

[]

[ "IPR039982" ]

0

1

0

[ "Eukaryota" ]

[ 2871 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 4, 3, 9, 2, 7 ]

6

true

Family

Large ribosomal subunit protein mL37/mL65

Ribosomal_mL37/mL65

9

IPR010794

10,794

Maltose operon periplasmic

MalM

Family

2,055

false

This family consists of several maltose operon periplasmic protein precursor (MalM) sequences. The function of this family is unknown [ ].

[ "GO:0008643", "GO:0042597" ]

[ "carbohydrate transport", "periplasmic space" ]

[ "biological_process", "cellular_component" ]

2

[ "PFAM" ]

[ "PF07148" ]

[ "MalM" ]

[ 2055 ]

1

[]

0

[]

0

[ "PUB00013017" ]

[ "1730061" ]

[ "Completion of the nucleotide sequence of the 'maltose B' region in Salmonella typhimurium: the high conservation of the malM gene suggests a selected physiological role for its product." ]

[ 1992 ]

1

[]

0

null

[ "Bacteria", "Beauveria bassiana D1-5", "mine drainage metagenome" ]

[ 2053, 1, 1 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Maltose operon periplasmic

MalM

6

IPR010795

10,795

Prenylcysteine lyase

Prenylcys_lyase

Domain

4,953

false

This entry represents a conserved region found in a group of prenylcysteine lyases ( ) that are approximately 500 residues long. Prenylcysteine lyase is a FAD-dependent thioether oxidase that degrades a variety of prenylcysteines, producing free cysteine, an isoprenoid aldehyde and hydrogen peroxide as products of the ...

[ "GO:0016670", "GO:0030328" ]

[ "oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor", "prenylcysteine catabolic process" ]

[ "molecular_function", "biological_process" ]

2

[ "PFAM" ]

[ "PF07156" ]

[ "Prenylcys_lyase" ]

[ 4953 ]

1

[ "EC", "REACTOME", "REACTOME" ]

[ "1.8.3.5", "R-HSA-114608", "R-MMU-114608" ]

[ "EC:1.8.3.5", "REACTOME:R-HSA-114608", "REACTOME:R-MMU-114608" ]

3

[ "9fxq" ]

1

[ "PUB00013019", "PUB00013020" ]

[ "12186880", "11716481" ]

[ "Stereospecificity and kinetic mechanism of human prenylcysteine lyase, an unusual thioether oxidase.", "Molecular cloning and characterization of the Cl(-) pump-associated 55-kDa protein in rat brain." ]

[ 2002, 2001 ]

2

[]

0

null

[ "Actinomycetes", "Eukaryota", "Halobacteriales" ]

[ 2, 4944, 7 ]

3

[ "Arabidopsis thaliana", "Danio rerio", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 3, 5, 11, 7, 1, 1, 9, 4 ]

8

true

Domain

Prenylcysteine lyase

Prenylcys_lyase

3

IPR010796

10,796

B9-type C2 domain

C2_B9-type_dom

Family

5,897

false

The C2 domain is one of the most prevalent eukaryotic lipid-binding domains deployed in diverse functional contexts. Distinct versions of the C2 domain have been recognized, the classical C2, the PI3K-type, the tensin-type, the B9-type, the DOCK-type, the NT-type and the Aida-type. Despite their limited sequence simila...

[]

0

[ "PFAM", "PROFILE", "PANTHER" ]

[ "PF07162", "PS51381", "PTHR12968" ]

[ "B9-C2", "C2_B9", "" ]

[ 5788, 5320, 5618 ]

3

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-DME-5610787", "R-HSA-141444", "R-HSA-2467813", "R-HSA-2500257", "R-HSA-5610787", "R-HSA-5620912", "R-HSA-5663220", "R-HSA-68877", "R-HSA-9648025", "R-MMU-141444", "R-MMU-2467813", "R-MMU-2500257", "R-MMU-5610787", "R-MMU-5620912", "R-MMU-5663220", "R-MMU-68877", "R-MMU-9648025", ...

[ "REACTOME:R-DME-5610787", "REACTOME:R-HSA-141444", "REACTOME:R-HSA-2467813", "REACTOME:R-HSA-2500257", "REACTOME:R-HSA-5610787", "REACTOME:R-HSA-5620912", "REACTOME:R-HSA-5663220", "REACTOME:R-HSA-68877", "REACTOME:R-HSA-9648025", "REACTOME:R-MMU-141444", "REACTOME:R-MMU-2467813", "REACTOME:R-...

26

[]

0

[ "PUB00033858", "PUB00043759", "PUB00043760", "PUB00057260", "PUB00069271", "PUB00069275", "PUB00069722", "PUB00101102", "PUB00101103", "PUB00101104", "PUB00101105" ]

[ "16415886", "17127412", "18337471", "20713135", "17185389", "19515853", "22179047", "27646273", "21763481", "26490104", "27577095" ]

[ "MKS1, encoding a component of the flagellar apparatus basal body proteome, is mutated in Meckel syndrome.", "Identification of ICIS-1, a new protein involved in cilia stability.", "Functional redundancy of the B9 proteins and nephrocystins in Caenorhabditis elegans ciliogenesis.", "Identification of novel fa...

[ 2006, 2007, 2008, 2010, 2007, 2009, 2012, 2016, 2011, 2016, 2016 ]

11

[]

0

null

[ "Eukaryota" ]

[ 5897 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 3, 5, 3, 35, 9, 12 ]

6

true

Family

B9-type C2 domain

C2_B9-type_dom

4

IPR010797

10,797

Peroxisome assembly protein 26

Pex26

Family

1,113

false

Pex26 is a type II peroxisomal membrane protein that recruits Pex6-Pex1 complexes to peroxisomes [ ]. Mutations in the Pex26 gene cause peroxisome biogenesis disorder complementation group 8 (PBD-CG8) and peroxisome biogenesis disorder 7A/B (PBD7A/B) [ ].

[ "GO:0044877", "GO:0045046", "GO:0005778" ]

[ "protein-containing complex binding", "protein import into peroxisome membrane", "peroxisomal membrane" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PFAM", "PANTHER" ]

[ "PF07163", "PTHR16262" ]

[ "Pex26", "" ]

[ 1100, 1086 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-9033241", "R-HSA-9603798", "R-MMU-9033241", "R-MMU-9603798" ]

[ "REACTOME:R-HSA-9033241", "REACTOME:R-HSA-9603798", "REACTOME:R-MMU-9033241", "REACTOME:R-MMU-9603798" ]

4

[]

0

[ "PUB00013022", "PUB00013023" ]

[ "12717447", "12851857" ]

[ "The pathogenic peroxin Pex26p recruits the Pex1p-Pex6p AAA ATPase complexes to peroxisomes.", "Mutations in novel peroxin gene PEX26 that cause peroxisome-biogenesis disorders of complementation group 8 provide a genotype-phenotype correlation." ]

[ 2003, 2003 ]

2

[]

0

null

[ "Opisthokonta" ]

[ 1113 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 10, 3, 2 ]

4

true

Family

Peroxisome assembly protein 26

Pex26

4

IPR010798

10,798

Triadin

Family

2,048

false

Triadin was first identified from rabbit skeletal muscle sarcoplasmic reticulum as an abundant single transmembrane protein [ ]. It binds to ryanodine receptor and calsequestrin in a Ca2+-dependent manner [ ]. Later, several triadin isoforms produced by the alternative splicing of a single TRDN gene were identified [ ,...

[ "GO:0005102", "GO:0016020", "GO:0016529" ]

[ "signaling receptor binding", "membrane", "sarcoplasmic reticulum" ]

[ "molecular_function", "cellular_component", "cellular_component" ]

3

[ "PANTHER" ]

[ "PTHR14106" ]

[ "" ]

[ 2048 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-2672351", "R-HSA-5578775", "R-MMU-2672351", "R-MMU-5578775", "R-RNO-2672351", "R-RNO-5578775" ]

[ "REACTOME:R-HSA-2672351", "REACTOME:R-HSA-5578775", "REACTOME:R-MMU-2672351", "REACTOME:R-MMU-5578775", "REACTOME:R-RNO-2672351", "REACTOME:R-RNO-5578775" ]

6

[]

0

[ "PUB00013026", "PUB00072941", "PUB00072943", "PUB00072945", "PUB00095317" ]

[ "11707337", "22422768", "1649631", "19403623", "26228554" ]

[ "Molecular cloning and characterization of mouse cardiac triadin isoforms.", "Absence of triadin, a protein of the calcium release complex, is responsible for cardiac arrhythmia with sudden death in human.", "Localization and partial characterization of the oligomeric disulfide-linked molecular weight 95,000 pr...

[ 2001, 2012, 1991, 2009, 2015 ]

5

[]

0

null

[ "Eukaryota", "Kangiella spongicola" ]

[ 2047, 1 ]

2

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 77, 14, 4, 7 ]

4

true

Family

Triadin

6

IPR010799

10,799

Microcystin LR degradation protein MlrC, C-terminal

MlrC_C

Domain

6,701

false

Proteins in this entry are involved in degradation of the cyanobacterial heptapeptide hepatotoxin microcystin LR, and are encoded in the mlr gene cluster [ ]. MlrC from Sphingomonas wittichii (strain RW1 / DSM 6014 / JCM 10273) is believed to mediate the last step of peptidolytic degradation of the tetrapeptide. It is ...

[]

0

[ "PFAM" ]

[ "PF07171" ]

[ "MlrC_C" ]

[ 6701 ]

1

[]

0

[ "3iuu", "7ylq" ]

2

[ "PUB00036077" ]

[ "11769251" ]

[ "Characterisation of a gene cluster involved in bacterial degradation of the cyanobacterial toxin microcystin LR." ]

[ 2001 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "metagenomes" ]

[ 37, 6127, 366, 171 ]

4

[]

0

true

Domain

Microcystin LR degradation protein MlrC, C-terminal

MlrC_C

9

IPR010800

10,800

Glycine rich protein

GRP

Family

2,187

false

This family consists of glycine rich proteins, including Arabidopsis AtGRP3 (At2g05520). AtGRP3 interacts with the receptor-like kinase AtWAK1 and functions in root size determination during development and in Aluminum stress [ ].

[]

0

[ "PFAM", "PANTHER" ]

[ "PF07172", "PTHR37389" ]

[ "GRP", "" ]

[ 1910, 1455 ]

2

[]

0

[]

0

[ "PUB00079183" ]

[ "26939065" ]

[ "AtGRP3 Is Implicated in Root Size and Aluminum Response Pathways in Arabidopsis." ]

[ 2016 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "viral metagenome" ]

[ 2, 2184, 1 ]

3

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 43, 20, 11 ]

3

true

Family

Glycine rich protein

GRP

1

IPR010801

10,801

Fibronectin-attachment

FAP

Domain

405

false

This family contains bacterial fibronectin-attachment proteins (FAP) which are rich in alanine and proline and seem to be restricted to mycobacteria. These proteins contain a fibronectin-binding motif that allows mycobacteria to bind to fibronectin in the extracellular matrix [ , ].

[ "GO:0050840", "GO:0005576" ]

[ "extracellular matrix binding", "extracellular region" ]

[ "molecular_function", "cellular_component" ]

2

[ "PFAM" ]

[ "PF07174" ]

[ "FAP" ]

[ 405 ]

1

[]

0

[ "5zx9", "5zxa" ]

2

[ "PUB00013028", "PUB00159894" ]

[ "9988684", "31175911" ]

[ "Characterization of the fibronectin binding motif for a unique mycobacterial fibronectin attachment protein, FAP.", "Functional and structural investigations of fibronectin-binding protein Apa from Mycobacterium tuberculosis." ]

[ 1999, 2019 ]

2

[]

0

null

[ "Bacillati" ]

[ 405 ]

1

[]

0

true

Domain

Fibronectin-attachment

FAP

8

IPR010802

10,802

Domain of unknown function DUF1400

DUF1400

Domain

1,420

false

This domain is specific to cyanobacterial proteins, its function and the function of the proteins it is associated with, are uncharacterised.

[]

0

[ "PFAM" ]

[ "PF07176" ]

[ "DUF1400" ]

[ 1420 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Cyanobacteriota" ]

[ 1420 ]

1

[]

0

true

Domain

Domain of unknown function DUF1400

DUF1400

3

IPR010803

10,803

Citrus tristeza virus P33

CTV_P33

Family

309

false

This family consists of several Citrus tristeza virus (CTV) P33 proteins. The function of P33 is unclear although it is known that the protein is not needed for virion formation [ ].

[]

0

[ "PFAM" ]

[ "PF07184" ]

[ "CTV_P33" ]

[ 309 ]

1

[]

0

[]

0

[ "PUB00011543" ]

[ "11112500" ]

[ "Closterovirus encoded HSP70 homolog and p61 in addition to both coat proteins function in efficient virion assembly." ]

[ 2000 ]

1

[]

0

null

[ "Citrus tristeza virus" ]

[ 309 ]

1

[]

0

true

Family

Citrus tristeza virus P33

CTV_P33

3

IPR010805

10,805

Kaposi s sarcoma-associated herpesvirus K8

KSHV_K8

Family

74

false

This family consists of Human herpesvirus 8 (HHV-8, Kaposi's sarcoma-associated herpesvirus) K8 proteins. HHV-8 is a human Gammaherpesvirus related to Epstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4) and Saimiriine herpesvirus 2 (Herpesvirus saimiri). HHV-8 open reading frame K8 encodes a basic region-leuc...

[]

0

[ "PFAM" ]

[ "PF07188" ]

[ "KSHV_K8" ]

[ 74 ]

1

[]

0

[]

0

[ "PUB00013033" ]

[ "12604819" ]

[ "Kaposi's sarcoma-associated herpesvirus K8 protein interacts with hSNF5." ]

[ 2003 ]

1

[]

0

null

[ "Rhadinovirus" ]

[ 74 ]

1

[]

0

true

Family

Kaposi s sarcoma-associated herpesvirus K8

KSHV_K8

3

IPR010806

10,806

Poxvirus, TNF receptor-II, C-terminal

Poxvirus_TNF-rcpt-II_C

Domain

382

false

This domain is found at the C-terminal end of Soluble TNF receptor II from Cowpox virus (CRMB1) and Cytokine response-modifying protein B from Variola virus (CrmB), and differently located in other sequences from poxvirus, including Protein OPG192 and Protein C8 from Vaccinia virus. CRMB1 and CrmB inhibit host immune d...

[]

0

[ "PFAM" ]

[ "PF07190" ]

[ "CrmD_SECRET" ]

[ 382 ]

1

[]

0

[ "3on9", "3ona" ]

2

[ "PUB00082525", "PUB00103700" ]

[ "8091665", "16581912" ]

[ "Cowpox virus contains two copies of an early gene encoding a soluble secreted form of the type II TNF receptor.", "A chemokine-binding domain in the tumor necrosis factor receptor from variola (smallpox) virus." ]

[ 1994, 2006 ]

2

[]

0

null

[ "Chordopoxvirinae", "Dipodomys ordii", "Longicatena caecimuris" ]

[ 380, 1, 1 ]

3

[]

0

true

Domain

Poxvirus, TNF receptor-II, C-terminal

Poxvirus_TNF-rcpt-II_C

3

IPR010808

10,808

Chemotaxis protein CheA, P2 response regulator-binding

CheA_P2-bd

Domain

3,976

false

Two-component signal transduction systems enable bacteria to sense, respond, and adapt to a wide range of environments, stressors, and growth conditions [ ]. Some bacteria can contain up to as many as 200 two-component systems that need tight regulation to prevent unwanted cross-talk [ ]. These pathways have been adapt...

[ "GO:0000155", "GO:0004673", "GO:0000160" ]

[ "phosphorelay sensor kinase activity", "protein histidine kinase activity", "phosphorelay signal transduction system" ]

[ "molecular_function", "molecular_function", "biological_process" ]

3

[ "PFAM" ]

[ "PF07194" ]

[ "P2" ]

[ 3976 ]

1

[ "EC" ]

[ "2.7.13.3" ]

[ "EC:2.7.13.3" ]

1

[ "1u0s" ]

1

[ "PUB00000966", "PUB00007866", "PUB00010651", "PUB00011096", "PUB00013035", "PUB00013246", "PUB00013247", "PUB00013562", "PUB00013563", "PUB00020801", "PUB00042804", "PUB00042805", "PUB00042806", "PUB00042807" ]

[ "9989504", "11406410", "12372152", "10966457", "10564504", "8868347", "10426948", "8029829", "1482126", "11145881", "16176121", "18076326", "11934609", "11489844" ]

[ "Structure of CheA, a signal-transducing histidine kinase.", "Histidine kinases and response regulator proteins in two-component signaling systems.", "Histidine protein kinases: key signal transducers outside the animal kingdom.", "Two-component signal transduction.", "Histidine kinases: diversity of domain...

[ 1999, 2001, 2002, 2000, 1999, 1996, 1999, 1994, 1992, 2000, 2005, 2007, 2002, 2001 ]

14

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "metagenomes" ]

[ 420, 3526, 4, 26 ]

4

[]

0

true

Domain

Chemotaxis protein CheA, P2 response regulator-binding

CheA_P2-bd

3

IPR010809

10,809

Flagellar hook-associated protein 2, C-terminal

FliD_C

Domain

12,666

false

The flagellar hook-associated protein 2 (HAP2 or FliD) forms the distal end of the flagella, and plays a role in mucin specific adhesion of the bacteria [ ]. This alignment covers the C-terminal region of the flagellar hook-associated protein 2.

[ "GO:0007155", "GO:0009288" ]

[ "cell adhesion", "bacterial-type flagellum" ]

[ "biological_process", "cellular_component" ]

2

[ "PFAM" ]

[ "PF07195" ]

[ "FliD_C" ]

[ 12666 ]

1

[]

0

[ "5fhy", "5gna", "5h5t", "5h5v", "5h5w", "5xlj", "5xlk", "6iwy", "6kty", "6sih", "9gnz", "9gsx", "9m6h" ]

13

[ "PUB00009465" ]

[ "9488388" ]

[ "The Pseudomonas aeruginosa flagellar cap protein, FliD, is responsible for mucin adhesion." ]

[ 1998 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "Thermoproteati", "unclassified sequences" ]

[ 12457, 33, 9, 167 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Domain

Flagellar hook-associated protein 2, C-terminal

FliD_C

6

IPR010810

10,810

Flagellin hook, IN motif

Flagellin_hook_IN_motif

Conserved_site

10,013

false

The function of this region is not clear, but it is found in many flagellar hook proteins, including FliD homologues [ ]. This motif is found in single copy or repeated in various flagellar proteins. Conserved Ile-Asn (IN) residues are seen at the centre of the motif. The diversity of these motifs makes it likely that ...

[]

0

[ "PFAM" ]

[ "PF07196" ]

[ "Flagellin_IN" ]

[ 10013 ]

1

[]

0

[ "2zbi", "3k8v", "3k8w", "5fhy", "5h5t", "5wk5", "5wk6", "5xlj", "5xlk", "6b5b", "6iwy", "6sih", "6x80", "8erm", "8sug", "9gnz", "9gsx", "9m6h", "9n8a", "9n8b", "9n8g", "9n8h", "9n8m", "9p7r" ]

24

[ "PUB00013036" ]

[ "11230454" ]

[ "Molecular characterization of fliD gene encoding flagellar cap and its expression among Clostridium difficile isolates from different serogroups." ]

[ 2001 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified Caudoviricetes", "unclassified sequences" ]

[ 9932, 12, 2, 67 ]

4

[]

0

true

Conserved_site

Flagellin hook, IN motif

Flagellin_hook_IN_motif

5

IPR010811

10,811

Domain of unknown function DUF1409

DUF1409

Domain

710

false

This represents a short conserved region (approximately 50 residues long), sometimes repeated, within a number of hypothetical Oryza sativa proteins of unknown function.

[]

0

[ "PFAM" ]

[ "PF07197" ]

[ "DUF1409" ]

[ 710 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Poaceae" ]

[ 710 ]

1

[ "Oryza sativa subsp. japonica" ]

[ 241 ]

1

true

Domain

Domain of unknown function DUF1409

DUF1409

2

IPR010812

10,812

Hypersensitivity response secretion-like, HrpJ

HrpJ-like

Domain

2,417

false

This entry represents a conserved region approximately 200 residues long within a number of bacterial hypersensitivity response secretion protein HrpJ and similar proteins. HrpJ forms part of a type III secretion system through which, in phytopathogenic bacterial species, virulence factors are thought to be delivered t...

[ "GO:0046903", "GO:0019867" ]

[ "secretion", "outer membrane" ]

[ "biological_process", "cellular_component" ]

2

[ "PFAM" ]

[ "PF07201" ]

[ "HrpJ" ]

[ 2417 ]

1

[]

0

[ "1xkp", "1xl3", "2vix", "2vj4", "2vj5", "4nrh", "4p3z", "4p40", "5c9e", "6gx7", "7yyg" ]

11

[ "PUB00012979", "PUB00012980", "PUB00013038" ]

[ "11053395", "9140973", "10449783" ]

[ "Characterization of SepL of enterohemorrhagic Escherichia coli.", "Functional analysis of ssaJ and the ssaK/U operon, 13 genes encoding components of the type III secretion apparatus of Salmonella Pathogenicity Island 2.", "Role of the Hrp type III protein secretion system in growth of Pseudomonas syringae pv....

[ 2000, 1997, 1999 ]

3

[ "IPR013401" ]

[]

1

0

1

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 2410, 4, 3 ]

3

[]

0

true

Domain

Hypersensitivity response secretion-like, HrpJ

HrpJ-like

2

IPR010813

10,813

Protein of unknown function DUF1413

DUF1413

Family

544

false

This family consists of several hypothetical bacterial proteins, which seem to occur in predominantly firmicute species. Members of this family are typically around 100 residues in length. The function of this family is unknown.

[]

0

[ "PFAM" ]

[ "PF07205" ]

[ "DUF1413" ]

[ 544 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Halorubrum distributum", "metagenomes" ]

[ 532, 1, 11 ]

3

[]

0

true

Family

Protein of unknown function DUF1413

DUF1413

7

IPR010815

10,815

Protein of unknown function DUF1418

DUF1418

Family

1,033

false

This family consists of several hypothetical Enterobacterial proteins of around 100 residues in length. Members of this family are often described as YbjC. In Escherichia coli the ybjC gene is located downstream of nfsA (which encodes the major oxygen-insensitive nitroreductase). It is thought that nfsA and ybjC form a...

[]

0

[ "PFAM" ]

[ "PF07214" ]

[ "DUF1418" ]

[ 1033 ]

1

[]

0

[]

0

[ "PUB00013045" ]

[ "11741843" ]

[ "Regulation of the nfsA Gene in Escherichia coli by SoxS." ]

[ 2002 ]

1

[]

0

null

[ "Bacteria", "Opisthokonta" ]

[ 1031, 2 ]

2

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Protein of unknown function DUF1418

DUF1418

5

IPR010816

10,816

Heterokaryon incompatibility Het-C

Het-C

Family

3,323

false

In filamentous fungi, het loci (for heterokaryon incompatibility) are believed to regulate self/nonself-recognition during vegetative growth. As filamentous fungi grow, hyphal fusion occurs within an individual colony to form a network. Hyphal fusion can occur also between different individuals to form a heterokaryon, ...

[]

0

[ "PFAM" ]

[ "PF07217" ]

[ "Het-C" ]

[ 3323 ]

1

[]

0

[]

0

[ "PUB00013047" ]

[ "9770498" ]

[ "Evidence for balancing selection operating at the het-c heterokaryon incompatibility locus in a group of filamentous fungi." ]

[ 1998 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "hydrothermal vent metagenome" ]

[ 216, 3106, 1 ]

3

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)" ]

[ 2 ]

1

true

Family

Heterokaryon incompatibility Het-C

Het-C

3

IPR010817

10,817

HemY, N-terminal

HemY_N

Domain

8,524

false

This entry represents the N terminus (approximately 150 residues) of bacterial HemY porphyrin biosynthesis proteins. These are membrane protein involved in a late step of protoheme IX synthesis [ ].

[]

0

[ "PFAM" ]

[ "PF07219" ]

[ "HemY_N" ]

[ 8524 ]

1

[]

0

[]

0

[ "PUB00013049" ]

[ "7928957" ]

[ "Bacillus subtilis HemY is a peripheral membrane protein essential for protoheme IX synthesis which can oxidize coproporphyrinogen III and protoporphyrinogen IX." ]

[ 1994 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 8430, 8, 86 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Domain

HemY, N-terminal

HemY_N

4

IPR010818

10,818

Protein of unknown function DUF1420

DUF1420

Family

70

false

This family consists of several hypothetical putative lipoproteins which seem to be found specifically in the bacterium Leptospira. Members of this family are typically around 670 resides in length and their function is unknown.

[]

0

[ "PFAM" ]

[ "PF07220" ]

[ "DUF1420" ]

[ 70 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Pseudomonadati", "marine metagenome" ]

[ 68, 2 ]

2

[]

0

true

Family

Protein of unknown function DUF1420

DUF1420

5

IPR010819

10,819

N-acylglucosamine 2-epimerase/Cellobiose 2-epimerase

AGE/CE

Family

12,260

false

This protein family includes cellobiose 2-epimerase, N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase), sulfoquinovose isomerase enzymes and similar sequences from cellular organisms [ , ]. N-acylglucosamine 2-epimerase converts N-acyl-D-glucosamine to N-acyl-D-mannosamine. Cellobiose 2-epimerase enzymes catalyse the ...

[ "GO:0016853" ]

[ "isomerase activity" ]

[ "molecular_function" ]

1

[ "PFAM" ]

[ "PF07221" ]

[ "GlcNAc_2-epim" ]

[ 12260 ]

1

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "5.1.3", "R-BTA-446210", "R-HSA-446210", "R-MMU-446210", "R-RNO-446210", "R-SSC-446210" ]

[ "EC:5.1.3", "REACTOME:R-BTA-446210", "REACTOME:R-HSA-446210", "REACTOME:R-MMU-446210", "REACTOME:R-RNO-446210", "REACTOME:R-SSC-446210" ]

6

[ "1fp3", "2afa", "2gz6", "2rgk", "2zbl", "3gt5", "3vw5", "3wkf", "3wkg", "3wkh", "3wki", "4z4j", "4z4l", "5x32", "5zhb", "5zig", "6f04", "7ag4", "7d5g", "8bry", "8brz", "8bs0", "8h1k", "8h1l", "8h1m", "8h1n", "8wbu", "8wbv", "9l8i", "9l8k" ]

30

[ "PUB00101179", "PUB00101180" ]

[ "31201453", "33484446" ]

[ "Enzymatic characteristics of D-mannose 2-epimerase, a new member of the acylglucosamine 2-epimerase superfamily.", "Biochemical Properties of a Novel D-Mannose Isomerase from Pseudomonas syringae for D-Mannose Production." ]

[ 2019, 2021 ]

2

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Siphoviridae sp. ctBLh2", "unclassified sequences" ]

[ 138, 10999, 1000, 1, 122 ]

5

[ "Danio rerio", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 1, 3, 4, 8 ]

5

true

Family

N-acylglucosamine 2-epimerase/Cellobiose 2-epimerase

AGE/CE

4

IPR010820

10,820

UBA-like domain DUF1421

DUF1421

Domain

2,002

false

This domain represents a conserved region that has a UBA-like fold. It is found in a number of plant proteins of unknown function.

[]

0

[ "PFAM" ]

[ "PF07223" ]

[ "DUF1421" ]

[ 2002 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota" ]

[ 4, 1998 ]

2

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 17, 14, 25 ]

3

true

Domain

UBA-like domain DUF1421

DUF1421

7

IPR010823

10,823

Portal protein Gp20

Portal_Gp20

Family

2,520

false

This family consists of several bacteriophage T4-like capsid assembly (or portal) proteins. The exact mechanism by which the double-stranded (ds) DNA bacteriophages incorporate the portal protein at a unique vertex of the icosahedral capsid is unknown. In phage T4, there is evidence that this vertex, constituted by 12 ...

[]

0

[ "HAMAP", "PFAM" ]

[ "MF_04114", "PF07230" ]

[ "PORTAL_T4", "Portal_T4" ]

[ 589, 2520 ]

2

[]

0

[ "3ja7", "6uzc" ]

2

[ "PUB00013054", "PUB00066735" ]

[ "8918937", "22429790" ]

[ "Novel mutants in the 5' upstream region of the portal protein gene 20 overcome a gp40-dependent prohead assembly block in bacteriophage T4.", "Extensive proteolysis of head and inner body proteins by a morphogenetic protease in the giant Pseudomonas aeruginosa phage φKZ." ]

[ 1996, 2012 ]

2

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "metagenomes" ]

[ 3, 23, 3, 2421, 70 ]

5

[]

0

true

Family

Portal protein Gp20

Portal_Gp20

9

IPR010824

10,824

Protein of unknown function DUF1425

DUF1425

Family

2,473

false

This family consists of uncharacterised bacterial proteins predominantly found in Proteobacteria, including YcfL from Escherichia coli and Putative lipoprotein from Campylobacter jejuni. The protein adopts a single domain configuration with two β-sheets formed respectively by three and four β-strands (β-sandwich) and c...

[]

0

[ "PFAM", "CDD" ]

[ "PF07233", "cd09030" ]

[ "DUF1425", "DUF1425" ]

[ 2442, 2412 ]

2

[]

0

[ "3o0l", "4gio" ]

2

[ "PUB00100676" ]

[ "22987763" ]

[ "Crystal structure of the Campylobacter jejuni Cj0090 protein reveals a novel variant of the immunoglobulin fold among bacterial lipoproteins." ]

[ 2012 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 2449, 3, 21 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Protein of unknown function DUF1425

DUF1425

7

IPR010825

10,825

Stress-inducible humoral factor Turandot

Turandot

Family

110

false

This family consists of several Drosophila species specific Turandot proteins. The Turandot A (TotA) gene encodes a humoral factor, which is secreted from the fat body and accumulates in the body fluids. TotA is strongly induced upon bacterial challenge, as well as by other types of stress such as high temperature, mec...

[ "GO:0002376" ]

[ "immune system process" ]

[ "biological_process" ]

1

[ "PFAM" ]

[ "PF07240" ]

[ "Turandot" ]

[ 110 ]

1

[]

0

[ "8pbv" ]

1

[ "PUB00013058", "PUB00095647", "PUB00095648" ]

[ "11369236", "11409894", "16611243" ]

[ "A humoral stress response in Drosophila.", "A family of Turandot-related genes in the humoral stress response of Drosophila.", "The MAPKKK Mekk1 regulates the expression of Turandot stress genes in response to septic injury in Drosophila." ]

[ 2001, 2001, 2006 ]

3

[]

0

null

[ "Sophophora" ]

[ 110 ]

1

[ "Drosophila melanogaster" ]

[ 16 ]

1

true

Family

Stress-inducible humoral factor Turandot

Turandot

5

IPR010826

10,826

Phlebovirus glycoprotein G1

Phlebovirus_G1

Domain

1,325

false

This domain is found in several Phlebovirus glycoprotein G1 sequences. Members of the Bunyaviridae family acquire an envelope by budding through the lipid bilayer of the Golgi complex. The budding compartment is thought to be determined by the accumulation of the two heterodimeric membrane glycoproteins G1 and G2 in th...

[ "GO:0016020", "GO:0044423" ]

[ "membrane", "virion component" ]

[ "cellular_component", "cellular_component" ]

2

[ "PFAM" ]

[ "PF07243" ]

[ "Phlebovirus_G1" ]

[ 1325 ]

1

[]

0

[ "5y0w", "5y0y", "5y10", "5y11", "6f8p", "6f9b", "6f9c", "6f9d", "6f9e", "6f9f", "6i9i", "6iea", "6ieb", "6iec", "6iek", "7x6u", "7x6w", "7x72", "8awm", "8i4t", "8ilq", "8wqw", "8wsn", "8wsp", "8xk5", "8xk6", "8xk8", "8yxi", "8zhq", "9jqu", "9jqv", "9l2k"...

34

[ "PUB00013059" ]

[ "9811692" ]

[ "Targeting of a short peptide derived from the cytoplasmic tail of the G1 membrane glycoprotein of Uukuniemi virus (Bunyaviridae) to the Golgi complex." ]

[ 1998 ]

1

[]

0

null

[ "Ecdysozoa", "Viruses" ]

[ 66, 1259 ]

2

[]

0

true

Domain

Phlebovirus glycoprotein G1

Phlebovirus_G1

5

IPR010827

10,827

POTRA domain, BamA/TamA-like

BamA/TamA_POTRA

Domain

28,286

false

In Gram-negative bacteria, β-barrel proteins are integrated into the outer membrane by the β-barrel assembly machinery, with key components of the machinery being the Omp85 family members BamA and TamA [ ]. The BamA periplasmic domain is composed of five globular subdomains in tandem called POTRA motifs. They are key t...

[ "GO:0019867" ]

[ "outer membrane" ]

[ "cellular_component" ]

1

[ "PFAM" ]

[ "PF07244" ]

[ "POTRA" ]

[ 28286 ]

1

[ "REACTOME" ]

[ "R-HSA-9760173" ]

[ "REACTOME:R-HSA-9760173" ]

1

[ "2qcz", "2qdf", "2v9h", "2x8x", "3efc", "3mc8", "3mc9", "3og5", "3q6b", "4bza", "4c00", "4c4v", "4k3b", "4k3c", "4pk1", "4qay", "4xga", "5ayw", "5d0o", "5d0q", "5efr", "5ekq", "5ljo", "5or1", "6izs", "6izt", "6j09", "6lyq", "6lyr", "6lys", "6lyu", "6smx"...

125

[ "PUB00078794", "PUB00084284", "PUB00084285", "PUB00084286", "PUB00084287", "PUB00084288" ]

[ "26243377", "27332128", "26427691", "25976323", "24411168", "24056943" ]

[ "Conserved features in TamA enable interaction with TamB to drive the activity of the translocation and assembly module.", "BamA POTRA Domain Interacts with a Native Lipid Membrane Surface.", "Purification and Bicelle Crystallization for Structure Determination of the E. coli Outer Membrane Protein TamA.", "A...

[ 2015, 2016, 2015, 2015, 2014, 2013 ]

6

[ "IPR034746" ]

[]

1

0

1

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 26941, 855, 490 ]

3

[ "Arabidopsis thaliana", "Escherichia coli (strain K12)", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 8, 2, 4, 12 ]

4

true

Domain

POTRA domain, BamA/TamA-like

BamA/TamA_POTRA

2

IPR010828

10,828

Alcohol acetyltransferase/N-acetyltransferase-like

Atf2/Sli1-like

Family

3,752

false

This entry includes alcohol O-acetyltransferase 2 (Atf2), PSTB2-interacting protein 1 (PBI1) and N-acetyltransferase Sli1 from budding yeasts. Atf2 catalyses the esterification of isoamyl alcohol by acetyl coenzyme A [ ]. PBI1 is a phosphatidic acid-binding protein involved in interorganelle phosphatidylserine (PtdSer)...

[]

0

[ "PFAM" ]

[ "PF07247" ]

[ "AATase" ]

[ 3752 ]

1

[]

0

[]

0

[ "PUB00013060", "PUB00078890", "PUB00158911" ]

[ "7764365", "15025559", "24366873" ]

[ "The purification, properties and internal peptide sequences of alcohol acetyltransferase isolated from Saccharomyces cerevisiae Kyokai No. 7.", "SLI1 (YGR212W) is a major gene conferring resistance to the sphingolipid biosynthesis inhibitor ISP-1, and encodes an ISP-1 N-acetyltransferase in yeast.", "An assemb...

[ 1993, 2004, 2014 ]

3

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "bioreactor metagenome" ]

[ 2, 124, 3623, 3 ]

4

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 2, 4, 1 ]

3

true

Family

Alcohol acetyltransferase/N-acetyltransferase-like

Atf2/Sli1-like

3

IPR010829

10,829

Eliciting plant response-like/Cerato-platanin

ELP/CP

Family

2,531

false

This entry represents a group of fungal proteins involved in plant pathogenesis and elicitation of plant defense responses including Cerato-platanin (CP) and Eliciting plant response-like (ELP) proteins. This entry also includes Heat-stable 19 kDa antigen and related fungal proteins. CP from the Ascomycete Ceratocystis...

[]

0

[ "PFAM", "CDD" ]

[ "PF07249", "cd22778" ]

[ "Cerato-platanin", "DPBB_CEPL-like" ]

[ 2520, 2259 ]

2

[]

0

[ "2kqa", "3m3g", "3suj", "3suk", "3sul", "3sum" ]

6

[ "PUB00013061", "PUB00044114", "PUB00044115", "PUB00102151", "PUB00163244", "PUB00163245" ]

[ "10455173", "17431609", "16931046", "23902259", "18487198", "25755658" ]

[ "Purification, characterization, and amino acid sequence of cerato-platanin, a new phytotoxic protein from Ceratocystis fimbriata f. sp. platani.", "Atomic force microscopy images suggest aggregation mechanism in cerato-platanin.", "Cerato-platanin, a phytotoxic protein from Ceratocystis fimbriata: expression i...

[ 1999, 2007, 2006, 2013, 2008, 2015 ]

6

[]

0

null

[ "Eukaryota" ]

[ 2531 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)" ]

[ 1 ]

1

true

Family

Eliciting plant response-like/Cerato-platanin

ELP/CP

6

IPR010831

10,831

Interleukin-23 alpha

IL-23_alpha

Family

386

false

This entry represents interleukin-23 subunit alpha, IL-23A (also known as Interleukin-23 subunit p19) associates with IL-12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity [ ]. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. ...

[ "GO:0005125", "GO:0006955", "GO:0005576" ]

[ "cytokine activity", "immune response", "extracellular region" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PFAM", "PANTHER" ]

[ "PF16649", "PTHR15947" ]

[ "IL23", "" ]

[ 385, 373 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-6785807", "R-HSA-9020933", "R-MMU-9020933", "R-RNO-9020933", "R-SSC-9020933" ]

[ "REACTOME:R-HSA-6785807", "REACTOME:R-HSA-9020933", "REACTOME:R-MMU-9020933", "REACTOME:R-RNO-9020933", "REACTOME:R-SSC-9020933" ]

5

[ "3d85", "3d87", "3duh", "3qwr", "4grw", "5mj3", "5mj4", "5mxa", "5mzv", "5njd", "6uib", "6wdq", "8cr8", "8oe4", "8uui" ]

15

[ "PUB00013064", "PUB00067932" ]

[ "11114383", "16424222" ]

[ "Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12.", "In vitro and in situ expression of IL-23 by keratinocytes in healthy skin and psoriasis lesions: enhanced expression in psoriatic skin." ]

[ 2000, 2006 ]

2

[]

0

null

[ "Gnathostomata" ]

[ 386 ]

1

[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 1, 2 ]

3

true

Family

Interleukin-23 alpha

IL-23_alpha

9

IPR010832

10,832

ProSAAS

Family

320

false

Prohormone convertases (PCs) 1 and 2 are a family of eukaryotic subtilisins thought to mediate the proteolytic cleavage of many peptide precursors [ ]. This family represents proSAAS, which belongs to MEROPS inhibitor family I49. It is a neuroendocrine secretory protein which is a potent endogenous PC1 inhibitor [ , ]....

[ "GO:0004866", "GO:0010951" ]

[ "endopeptidase inhibitor activity", "negative regulation of endopeptidase activity" ]

[ "molecular_function", "biological_process" ]

2

[ "PFAM", "PANTHER" ]

[ "PF07259", "PTHR15531" ]

[ "ProSAAS", "" ]

[ 320, 177 ]

2

[]

0

[]

0

[ "PUB00013066", "PUB00013067", "PUB00013068", "PUB00071620", "PUB00071621", "PUB00071622", "PUB00071628", "PUB00071629", "PUB00071630", "PUB00071631", "PUB00071632", "PUB00153342", "PUB00153343", "PUB00153344", "PUB00153345" ]

[ "10632593", "11742530", "12914799", "10816562", "15283695", "10409610", "24102330", "11719503", "22164236", "20367757", "20830308", "15935061", "27457957", "3339648", "3510705" ]

[ "Identification and characterization of proSAAS, a granin-like neuroendocrine peptide precursor that inhibits prohormone processing.", "Processing of proSAAS in neuroendocrine cell lines.", "An N-terminal fragment of ProSAAS (a granin-like neuroendocrine peptide precursor) is associated with tau inclusions in P...

[ 2000, 2002, 2003, 2000, 2004, 1999, 2014, 2002, 2011, 2010, 2010, 2005, 2016, 1988, 1986 ]

15

[]

0

null

[ "Opisthokonta" ]

[ 320 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 1, 2, 4 ]

4

true

Family

ProSAAS

4

IPR010835

10,835

Protein of unknown function DUF1439

DUF1439

Family

2,963

false

This family consists of several hypothetical bacterial proteins of around 190 residues in length. Several members of this family are annotated as being putative lipoproteins and are often known as YceB. The function of this family is unknown.

[]

0

[ "PFAM" ]

[ "PF07273" ]

[ "DUF1439" ]

[ 2963 ]

1

[]

0

[ "3l6i" ]

1

[]

0

[]

0

null

[ "Bacteria", "Opisthokonta", "metagenomes" ]

[ 2942, 5, 16 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Protein of unknown function DUF1439

DUF1439

7

IPR010836

10,836

SapC

Family

3,958

false

This family contains a number of bacterial SapC proteins approximately 250 residues long. In Campylobacter fetus, SapC forms part of a paracrystalline surface layer (S-layer) that confers serum resistance [ ].

[]

0

[ "PFAM" ]

[ "PF07277" ]

[ "SapC" ]

[ 3958 ]

1

[]

0

[]

0

[ "PUB00013085" ]

[ "9851986" ]

[ "Campylobacter fetus surface layer proteins are transported by a type I secretion system." ]

[ 1998 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 3911, 9, 38 ]

3

[]

0

true

Family

SapC

7

IPR010838

10,838

Protein of unknown unction DUF1444

DUF1444

Family

1,761

false

This family contains several hypothetical bacterial proteins of unknown function that are approximately 250 residues long.

[]

0

[ "HAMAP", "NCBIFAM", "PFAM", "PIRSF" ]

[ "MF_01548", "NF010189", "PF07285", "PIRSF012562" ]

[ "UPF0354", "PRK13668.1", "DUF1444", "UCP012562" ]

[ 900, 1349, 1761, 1202 ]

4

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 1754, 3, 4 ]

3

[]

0

true

Family

Protein of unknown unction DUF1444

DUF1444

9

IPR010840

10,840

Inner membrane protein YqiJ, OB-fold domain

YqiJ_OB

Domain

1,794

false

This entry represents the OB-fold domain found in several bacterial proteins, including the inner membrane protein YqiJ from E. coli ( ), whose function is not clear.

[]

0

[ "PFAM" ]

[ "PF07290" ]

[ "YqiJ_OB" ]

[ 1794 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Ecdysozoa", "metagenomes" ]

[ 1787, 2, 5 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Domain

Inner membrane protein YqiJ, OB-fold domain

YqiJ_OB

2

IPR010841

10,841

Elongation factor G-binding protein, N-terminal

EF-G-binding_N

Domain

1,451

false

This domain can be found in the N terminus of the FusB ( ), FusC ( ), and FusD ( ) proteins from Staphylococcus aureus. They are elongation factor G (EF-G) binding proteins that are linked to the fusidic acid (FA) resistance in S. aureus [ , ].

[]

0

[ "PFAM" ]

[ "PF07299" ]

[ "EF-G-binding_N" ]

[ 1451 ]

1

[]

0

[ "2mzw", "2yb5", "4adn", "4ado", "4e4b", "9ghc", "9ghd", "9ghe", "9ghf", "9ghg", "9ghh" ]

11

[ "PUB00075618", "PUB00075619", "PUB00076954", "PUB00076956" ]

[ "22308410", "22645663", "24277045", "21546625" ]

[ "Ribosome clearance by FusB-type proteins mediates resistance to the antibiotic fusidic acid.", "Structure and function of FusB: an elongation factor G-binding fusidic acid resistance protein active in ribosomal translocation and recycling.", "A novel staphylococcal cassette chromosomal element, SCCfusC, carryi...

[ 2012, 2012, 2014, 2011 ]

4

[]

0

null

[ "Bacillati", "bioreactor metagenome" ]

[ 1449, 2 ]

2

[]

0

true

Domain

Elongation factor G-binding protein, N-terminal

EF-G-binding_N

9

IPR010843

10,843

Uncharacterised protein family AroM

Uncharacterised_AroM

Family

1,862

false

This family consists of several bacterial and archaeal AroM proteins. In Escherichia coli the aroM gene is cotranscribed with aroL [ ]. The function of this family is unknown.

[]

0

[ "PFAM" ]

[ "PF07302" ]

[ "AroM" ]

[ 1862 ]

1

[]

0

[]

0

[ "PUB00013092" ]

[ "3001025" ]

[ "Nucleotide sequence of the transcription unit containing the aroL and aroM genes from Escherichia coli K-12." ]

[ 1986 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "metagenomes" ]

[ 40, 1768, 26, 28 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Uncharacterised protein family AroM

Uncharacterised_AroM

4

IPR010845

10,845

Flagellar FlaF

FlaF

Family

2,416

false

This family consists of several bacterial FlaF flagellar proteins. FlaF and FlaG are trans-acting, regulatory factors that modulate flagellin synthesis during flagellum biogenesis [ ].

[ "GO:0044781" ]

[ "bacterial-type flagellum organization" ]

[ "biological_process" ]

1

[ "PFAM" ]

[ "PF07309" ]

[ "FlaF" ]

[ 2416 ]

1

[]

0

[]

0

[ "PUB00013096" ]

[ "1699845" ]

[ "Nucleotide sequence of the Caulobacter crescentus flaF and flbT genes and an analysis of codon usage in organisms with G + C-rich genomes." ]

[ 1990 ]

1

[]

0

null

[ "Bacteria", "unclassified sequences" ]

[ 2399, 17 ]

2

[]

0

true

Family

Flagellar FlaF

FlaF

2

IPR010846

10,846

N-acetylmuramoyl-L-alanine amidase-like

AmiA-like

Family

2,472

false

This entry represents a family of bacterial proteins, including N-acetylmuramoyl-L-alanine amidase (AmiA) from Bacteroides uniformis (BACUNI_02947, ). This highly specific enzyme hydrolyses GlcNAc-1,6-anhydro-MurNAc-peptide into disaccharide and stem peptide. It shows an α/β/α three-layered sandwich fold with a catalyt...

[]

0

[ "PFAM" ]

[ "PF07313" ]

[ "AmiA-like" ]

[ 2472 ]

1

[]

0

[ "2im9", "2p1g", "4h4j", "4q5k", "4q68" ]

5

[ "PUB00100890" ]

[ "25465128" ]

[ "Structure-guided functional characterization of DUF1460 reveals a highly specific NlpC/P60 amidase family." ]

[ 2014 ]

1

[]

0

null

[ "Bacteria", "Pancrustacea", "metagenomes" ]

[ 2423, 2, 47 ]

3

[]

0

true

Family

N-acetylmuramoyl-L-alanine amidase-like

AmiA-like

7

IPR010848

10,848

Protein of unknown function DUF1465

DUF1465

Family

1,820

false

This family consists of several hypothetical bacterial proteins of around 180 residues in length. The function of this family is unknown.

[]

0

[ "PFAM" ]

[ "PF07323" ]

[ "DUF1465" ]

[ 1820 ]

1

[]

0

[ "3ctw" ]

1

[]

0

[]

0

null

[ "Bacteria", "ecological metagenomes" ]

[ 1806, 14 ]

2

[]

0

true

Family

Protein of unknown function DUF1465

DUF1465

3

IPR010849

10,849

Gonadal family

Gonadal

Family

1,725

false

This family contains DiGeorge syndrome critical region 6 (DGCR6) proteins (approximately 200 residues long) of a number of vertebrates. DGCR6 is a candidate for involvement in the DiGeorge syndrome pathology by playing a role in neural crest cell migration into the third and fourth pharyngeal pouches, the structures fr...

[]

0

[ "PFAM", "PANTHER" ]

[ "PF07324", "PTHR13054" ]

[ "DGCR6", "" ]

[ 1623, 1681 ]

2

[]

0

[]

0

[ "PUB00013100" ]

[ "8733130" ]

[ "Isolation of a novel gene from the DiGeorge syndrome critical region with homology to Drosophila gdl and to human LAMC1 genes." ]

[ 1996 ]

1

[]

0

null

[ "Eukaryota" ]

[ 1725 ]

1

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 2, 11, 6, 5 ]

5

true

Family

Gonadal family

Gonadal

5

IPR010850

10,850

Neuroparsin

Family

254

false

This family consists of several locust specific neuroparsin proteins. Neuroparsins are produced by the A1 type of protocerebral median neurosecretory cells of the PI-CC system and display pleiotropic activities: inhibition of the effect of juvenile hormone, stimulation of fluid reabsorption of isolated recta, induction...

[]

0

[ "PFAM", "PIRSF" ]

[ "PF07327", "PIRSF001836" ]

[ "Neuroparsin", "Neuroparsin" ]

[ 254, 5 ]

2

[]

0

[]

0

[ "PUB00013101" ]

[ "9114464" ]

[ "Peptides in the locusts, Locusta migratoria and Schistocerca gregaria." ]

[ 1997 ]

1

[]

0

null

[ "Arthropoda", "Corynebacterium phoceense" ]

[ 253, 1 ]

2

[]

0

true

Family

Neuroparsin

1

IPR010851

10,851

Defensin-like protein

DEFL

Family

2,791

false

This family consists of defensin-like proteins from plants. Plant genomes contain several hundred defensin-like (DEFL) genes that encode short cysteine-rich proteins resembling defensins, which are known antimicrobial polypeptides [ ]. Arabidopsis thaliana has more than 300 DEFL genes, and they are likely to be involve...

[]

0

[ "PFAM", "PFAM", "PANTHER", "PANTHER" ]

[ "PF07333", "PF25052", "PTHR33830", "PTHR34783" ]

[ "SLR1-BP", "AtDEF-like", "", "" ]

[ 1853, 842, 1176, 185 ]

4

[]

0

[]

0

[ "PUB00092658", "PUB00092659" ]

[ "23527067", "23271953" ]

[ "Spatio-temporal expression patterns of Arabidopsis thaliana and Medicago truncatula defensin-like genes.", "A species-specific cluster of defensin-like genes encodes diffusible pollen tube attractants in Arabidopsis." ]

[ 2013, 2012 ]

2

[]

0

null

[ "Eukaryota" ]

[ 2791 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 169, 12, 11 ]

3

true

Family

Defensin-like protein

DEFL

2

IPR010852

10,852

Putative stress-induced transcription regulator

ABATE

Family

19,812

false

The structure of one member of the ABATE domain family consists of a two-domain organisation, with the N-terminal domain presenting a new fold called the ABATE domain that may bind an as yet unknown ligand. The C-terminal domain forms a treble-clef zinc-finger that is likely to be involved in DNA binding. suggests a ro...

[]

0

[ "PFAM", "PANTHER" ]

[ "PF07336", "PTHR35525" ]

[ "ABATE", "" ]

[ 16284, 19506 ]

2

[]

0

[ "3h0n" ]

1

[ "PUB00054176" ]

[ "20944211" ]

[ "The structure of Jann_2411 (DUF1470) from Jannaschia sp. at 1.45 A resolution reveals a new fold (the ABATE domain) and suggests its possible role as a transcription regulator." ]

[ 2010 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 19773, 2, 37 ]

3

[]

0

true

Family

Putative stress-induced transcription regulator

ABATE

7

IPR010853

10,853

DC-EC

CagY_M

Repeat

320

false

This repeat is found in the CagY proteins - part of the CAG pathogenicity island - and involved in delivery of the protein CagA into host cells [ ]. It forms part of a surface needle structure, and this repeat may form an α-helical rod structure [ ]. The repeat contains a conserved -DC- and -EC-, which are regularly sp...

[]

0

[ "PFAM" ]

[ "PF07337" ]

[ "CagY_M" ]

[ 320 ]

1

[]

0

[ "6odi", "6x6j", "6x6k", "6x6l", "6x6s" ]

5

[ "PUB00013106" ]

[ "12823823" ]

[ "A novel sheathed surface organelle of the Helicobacter pylori cag type IV secretion system." ]

[ 2003 ]

1

[]

0

null

[ "Bacteria", "Thalassiosira pseudonana" ]

[ 319, 1 ]

2

[]

0

true

Repeat

DC-EC

CagY_M

6

IPR010854

10,854

YdgH/BhsA/McbA-like domain

YdgH/BhsA/McbA-like_dom

Domain

12,059

false

This domain is found in several Enterobacterial proteins of around 90 residues in length, including E. coli YdgH, YhcN, BhsA and McbA, which play a role in stress response, biofilm formation, and pathogenesis [ , ]. BhsA (also known as ComC) reduces the permeability of the outer membrane to copper and may decrease biof...

[]

0

[ "PFAM" ]

[ "PF07338" ]

[ "YdgH_BhsA-like" ]

[ 12059 ]

1

[]

0

[ "2jna", "2m2j", "2ma4", "2ma8", "2noc", "4evu" ]

6

[ "PUB00097758", "PUB00097759", "PUB00097760" ]

[ "31534833", "25010333", "22089859" ]

[ "Proteomics and bioinformatics analysis reveal potential roles of cadmium-binding proteins in cadmium tolerance and accumulation of <i>Enterobacter cloacae</i>.", "Structural and functional characterization of DUF1471 domains of Salmonella proteins SrfN, YdgH/SssB, and YahO.", "The copper-inducible ComR (YcfQ) ...

[ 2019, 2014, 2012 ]

3

[]

0

null

[ "Bacteria", "Chimalliviridae", "Opisthokonta", "metagenomes" ]

[ 12021, 15, 13, 10 ]

4

[ "Escherichia coli (strain K12)" ]

[ 10 ]

1

true

Domain

YdgH/BhsA/McbA-like domain

YdgH/BhsA/McbA-like_dom

9

IPR010855

10,855

Cytomegalovirus IE1/IE2

Cytomega_IE1/IE2

Family

264

false

Expression from a human cytomegalovirus early promoter (E1.7) has been shown to be activated in trans by the IE2 gene product. Although the IE1 gene product alone had no effect on this early viral promoter, maximal early promoter activity was detected when both IE1 and IE2 gene products were present [ ]. The IE1 protei...

[ "GO:0039695" ]

[ "DNA-templated viral transcription" ]

[ "biological_process" ]

1

[ "PFAM" ]

[ "PF07340" ]

[ "Herpes_IE1" ]

[ 264 ]

1

[ "REACTOME", "REACTOME" ]

[ "R-HSA-9609690", "R-HSA-9610379" ]

[ "REACTOME:R-HSA-9609690", "REACTOME:R-HSA-9610379" ]

2

[ "4wic", "4wid", "6tgz" ]

3

[ "PUB00013107" ]

[ "2157038" ]

[ "Transactivation of a human cytomegalovirus early promoter by gene products from the immediate-early gene IE2 and augmentation by IE1: mutational analysis of the viral proteins." ]

[ 1990 ]

1

[]

0

null

[ "Betaherpesvirinae" ]

[ 264 ]

1

[]

0

true

Family

Cytomegalovirus IE1/IE2

Cytomega_IE1/IE2

2

IPR010856

10,856

Gig2-like

Family

5,333

false

This entry represents a family of proteins predominantly found in fungi and bacteria, including Gig2 from Candida albicans ( ) and Uncharacterized protein YbiU from Escherichia coli. Gig2 is a putative oxidoreductase thought to play a role in the undefined GlcNAc metabolic network. It folds into a single large domain w...

[]

0

[ "PFAM", "PANTHER" ]

[ "PF07350", "PTHR30613" ]

[ "Gig2-like", "" ]

[ 5322, 5272 ]

2

[]

0

[ "2csg", "2dbi", "2dbn", "4rgk", "6akz", "7twc", "7twe" ]

7

[ "PUB00100975" ]

[ "31743702" ]

[ "Crystal structure of Gig2 protein from Candida albicans provides a structural insight into DUF1479 family oxygenases." ]

[ 2020 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "ecological metagenomes" ]

[ 1992, 3332, 9 ]

3

[ "Escherichia coli (strain K12)", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)" ]

[ 1, 2 ]

2

true

Family

Gig2-like

4

IPR010857

10,857

Zona-pellucida-binding

Sp38-bd

Family

1,474

false

This family contains a number of zona-pellucida-binding proteins that seem to be restricted to mammals. These are sperm proteins that bind to the 90kDa family of zona pellucida glycoproteins in a calcium-dependent manner [ ]. These represent some of the specific molecules that mediate the first steps of gamete interact...

[ "GO:0007339", "GO:0005576" ]

[ "binding of sperm to zona pellucida", "extracellular region" ]

[ "biological_process", "cellular_component" ]

2

[ "PANTHER" ]

[ "PTHR15443" ]

[ "" ]

[ 1474 ]

1

[]

0

[]

0

[ "PUB00013111", "PUB00013112" ]

[ "7729589", "9378618" ]

[ "Amino acid sequences of porcine Sp38 and proacrosin required for binding to the zona pellucida.", "Molecules involved in mammalian sperm-egg interaction." ]

[ 1995, 1998 ]

2

[]

0

null

[ "Bilateria" ]

[ 1474 ]

1

[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 5, 6, 6 ]

3

true

Family

Zona-pellucida-binding

Sp38-bd

5

IPR010860

10,860

CAMP factor

CAMP_factor

Family

226

false

This family consists of several bacterial CAMP factor (Cfa) proteins, which seem to be specific to Streptococcus species. The CAMP reaction is a synergistic lysis of erythrocytes by the interaction of an extracellular protein (CAMP factor) produced by some streptococcal species with the Staphylococcus aureus sphingomye...

[]

0

[ "PFAM" ]

[ "PF07373" ]

[ "CAMP_factor" ]

[ 226 ]

1

[]

0

[ "5h6i", "5y2g", "6jlc", "9kx0" ]

4

[ "PUB00013119" ]

[ "10456923" ]

[ "Identification, cloning, and expression of the CAMP factor gene (cfa) of group A streptococci." ]

[ 1999 ]

1

[]

0

null

[ "Bacillati", "Opisthokonta" ]

[ 223, 3 ]

2

[ "Mus musculus" ]

[ 1 ]

1

true

Family

CAMP factor

CAMP_factor

8