LiteFold/InterPro · Datasets at Hugging Face

IPR010592

10,592

Extracytoplasmic thiamine-binding lipoprotein

CypI

Family

187

false

Thiamine-binding lipoprotein (Cypl) and related proteins are specific to Mycoplasma species. Cypl, also known as p37, whose gene is part of an operon encoding two additional proteins, which are highly similar to components of the periplasmic binding-protein-dependent transport systems of Gram-negative bacteria. It has ...

[]

0

[ "NCBIFAM", "PFAM", "PIRSF" ]

[ "NF045838", "PF06646", "PIRSF004523" ]

[ "MG289_thiam_LP", "CypI", "Mycoplasma_p37" ]

[ 178, 187, 59 ]

3

[]

0

[ "3e78", "3e79", "3eki", "3myu" ]

4

[ "PUB00012775", "PUB00051608", "PUB00051724", "PUB00065399", "PUB00154806" ]

[ "3208756", "19020356", "19233924", "21117240", "28036384" ]

[ "A mycoplasma high-affinity transport system and the in vitro invasiveness of mouse sarcoma cells.", "Structure determination of the cancer-associated Mycoplasma hyorhinis protein Mh-p37.", "Structural insights into the extracytoplasmic thiamine-binding lipoprotein p37 of Mycoplasma hyorhinis.", "Insights int...

[ 1988, 2008, 2009, 2011, 2016 ]

5

[]

0

null

[ "Bacteria" ]

[ 187 ]

1

[]

0

true

Family

Extracytoplasmic thiamine-binding lipoprotein

CypI

7

IPR010594

10,594

Autographa californica nuclear polyhedrosis virus (AcMNPV), Ac75

AcMNPV_Ac75

Family

121

false

This entry is represented by Autographa californica nuclear polyhedrosis virus (AcMNPV) protein Ac75, which is required for the egress of nucleocapsids from the nucleus, formation of intranuclear microvesicles and subsequent budded virion formation, in addition to protein Ac93. Ac75 is not an integral membrane protein,...

[]

0

[ "PFAM" ]

[ "PF06648" ]

[ "AcMNPV_Ac75" ]

[ 121 ]

1

[]

0

[]

0

[ "PUB00089650" ]

[ "29212928" ]

[ "Autographa californica Multiple Nucleopolyhedrovirus ac75 Is Required for the Nuclear Egress of Nucleocapsids and Intranuclear Microvesicle Formation." ]

[ 2018 ]

1

[]

0

null

[ "Baculoviridae" ]

[ 121 ]

1

[]

0

true

Family

Autographa californica nuclear polyhedrosis virus (AcMNPV), Ac75

AcMNPV_Ac75

5

IPR010595

10,595

Protein of unknown function DUF1161

DUF1161

Family

2,801

false

This family consists of several short, hypothetical bacterial proteins of unknown function.

[]

0

[ "PFAM" ]

[ "PF06649" ]

[ "DUF1161" ]

[ 2801 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 2793, 2, 6 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Protein of unknown function DUF1161

DUF1161

5

IPR010596

10,596

Methuselah, N-terminal domain

Methuselah_N_dom

Domain

1,215

false

Drosophila Methuselah (Mth) mutants have a 35% increase in average lifespan and increased resistance to several forms of stress, including heat, starvation, and oxidative damage. The protein affected by this mutation is related to G protein-coupled receptors of the secretin receptor family. Mth, like secretin receptor ...

[ "GO:0004930" ]

[ "G protein-coupled receptor activity" ]

[ "molecular_function" ]

1

[ "PFAM", "CDD" ]

[ "PF06652", "cd00251" ]

[ "Methuselah_N", "Mth_Ecto" ]

[ 1215, 312 ]

2

[]

0

[ "1fjr", "2pzx" ]

2

[ "PUB00012777", "PUB00048826" ]

[ "11274391", "17546039" ]

[ "Crystal structure of the ectodomain of Methuselah, a Drosophila G protein-coupled receptor associated with extended lifespan.", "Extension of Drosophila melanogaster life span with a GPCR peptide inhibitor." ]

[ 2001, 2007 ]

2

[]

0

null

[ "Bilateria" ]

[ 1215 ]

1

[ "Drosophila melanogaster" ]

[ 22 ]

1

true

Domain

Methuselah, N-terminal domain

Methuselah_N_dom

2

IPR010598

10,598

D-glucuronyl C5-epimerase, C-terminal

C5-epim_C

Domain

2,597

false

This entry represents the C terminus conserved region of known or predicted D-glucuronyl C5-epimerases. D-glucuronyl C5-epimerase converts D-glucuronic acid residues adjacent to N-sulfate sugar residues to L-iduronic acid residues, both in maturing heparan sulfate (HS) and heparin chains [ , ].

[]

0

[ "PFAM" ]

[ "PF06662" ]

[ "C5-epim_C" ]

[ 2597 ]

1

[ "EC", "METACYC", "REACTOME" ]

[ "5.1.3.17", "PWY-6558", "R-HSA-2022928" ]

[ "EC:5.1.3.17", "METACYC:PWY-6558", "REACTOME:R-HSA-2022928" ]

3

[ "4pw2", "4pxq", "6hzz", "6i01", "6i02" ]

5

[ "PUB00088175", "PUB00088176" ]

[ "16156897", "25568314" ]

[ "D-glucuronyl C5-epimerase acts in dorso-ventral axis formation in zebrafish.", "Structural and functional study of D-glucuronyl C5-epimerase." ]

[ 2005, 2015 ]

2

[]

0

null

[ "Archaea", "Bacteria", "Opisthokonta", "ecological metagenomes" ]

[ 73, 585, 1925, 14 ]

4

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 5, 2, 3, 2, 2 ]

6

true

Domain

D-glucuronyl C5-epimerase, C-terminal

C5-epim_C

3

IPR010600

10,600

Inter-alpha-trypsin inhibitor heavy chain, C-terminal

ITI_HC_C

Domain

5,512

false

This entry represents the C-terminal region of inter-alpha-trypsin inhibitor heavy chains. Inter-alpha-trypsin inhibitors are glycoproteins with a high inhibitory activity against trypsin, built up from different combinations of four polypeptides: bikunin and the three heavy chains that belong to this family (HC1, HC2,...

[ "GO:0004867", "GO:0030212" ]

[ "serine-type endopeptidase inhibitor activity", "hyaluronan metabolic process" ]

[ "molecular_function", "biological_process" ]

2

[ "PFAM" ]

[ "PF06668" ]

[ "ITI_HC_C" ]

[ 5512 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-114608", "R-HSA-114608", "R-HSA-381426", "R-HSA-8957275", "R-MMU-114608", "R-MMU-381426", "R-MMU-8957275", "R-RNO-114608", "R-SSC-381426", "R-SSC-8957275" ]

[ "REACTOME:R-BTA-114608", "REACTOME:R-HSA-114608", "REACTOME:R-HSA-381426", "REACTOME:R-HSA-8957275", "REACTOME:R-MMU-114608", "REACTOME:R-MMU-381426", "REACTOME:R-MMU-8957275", "REACTOME:R-RNO-114608", "REACTOME:R-SSC-381426", "REACTOME:R-SSC-8957275" ]

10

[ "9c4f", "9c4n" ]

2

[]

0

[]

0

null

[ "Bilateria" ]

[ 5512 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 9, 22, 15, 22 ]

4

true

Domain

Inter-alpha-trypsin inhibitor heavy chain, C-terminal

ITI_HC_C

7

IPR010601

10,601

Protein of unknown function DUF1182

DUF1182

Family

187

false

This family consists of several hypothetical proteins of around 360 residues in length and seems to be specific to Caenorhabditis elegans. The function of this family is unknown.

[]

0

[ "PFAM", "PANTHER" ]

[ "PF06681", "PTHR38614" ]

[ "DUF1182", "" ]

[ 78, 184 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Rhabditida" ]

[ 187 ]

1

[ "Caenorhabditis elegans" ]

[ 6 ]

1

true

Family

Protein of unknown function DUF1182

DUF1182

1

IPR010603

10,603

ATP-dependent Clp protease ATP-binding subunit ClpX, zinc ribbon domain

Znf_CppX_C4

Domain

24,877

false

The ClpX heat shock protein of Escherichia coli is a member of the universally conserved Hsp100 family of proteins, and possesses a putative zinc finger motif of the C4 type [ ]. This presumed zinc binding domain (ZBD) is found at the N terminus of the ClpX protein. ClpX is an ATPase which functions both as a substrate...

[ "GO:0008270", "GO:0046983" ]

[ "zinc ion binding", "protein dimerization activity" ]

[ "molecular_function", "molecular_function" ]

2

[ "PFAM", "SMART" ]

[ "PF06689", "SM00994" ]

[ "zf-C4_ClpX", "zf-C4_ClpX" ]

[ 24626, 24814 ]

2

[]

0

[ "1ovx", "2ds5", "2ds6", "2ds7", "2ds8", "6sfw", "6vfs", "6vfx", "8e91", "8et3", "9ndj", "9pio", "9pjd" ]

13

[ "PUB00014077", "PUB00014898", "PUB00014969", "PUB00035804", "PUB00035805", "PUB00035806", "PUB00035807", "PUB00035812" ]

[ "12665246", "11278349", "14525985", "17210253", "15963892", "15718139", "10529348", "11179890" ]

[ "Zinc fingers--folds for many occasions.", "Structure-function analysis of the zinc-binding region of the Clpx molecular chaperone.", "Solution structure of the dimeric zinc binding domain of the chaperone ClpX.", "Sticky fingers: zinc-fingers as protein-recognition motifs.", "Multiple modes of RNA recognit...

[ 2002, 2001, 2003, 2007, 2005, 2005, 1999, 2001 ]

8

[ "IPR059188" ]

[]

1

0

1

[ "Bacteria", "Caudoviricetes", "Eukaryota", "Methanobrevibacter", "unclassified sequences" ]

[ 24320, 14, 53, 10, 480 ]

5

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Domain

ATP-dependent Clp protease ATP-binding subunit ClpX, zinc ribbon domain

Znf_CppX_C4

5

IPR010605

10,605

Protein of unknown function DUF1191

DUF1191

Family

2,687

false

This family contains hypothetical plant proteins of unknown function.

[]

0

[ "PFAM", "PANTHER" ]

[ "PF06697", "PTHR33512" ]

[ "DUF1191", "" ]

[ 2636, 2627 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Streptophyta" ]

[ 2687 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 29, 9, 11 ]

3

true

Family

Protein of unknown function DUF1191

DUF1191

6

IPR010606

10,606

Mib-herc2

Mib_Herc2

Domain

9,089

false

Mib is a RING ubiquitin ligase in the Notch pathway. Mib interacts with the intracellular domain of Delta to promote its ubiquitylation and internalisation. Cell transplantation studies suggest that mib function is essential in the signalling cell for efficient activation of Notch in neighbouring cells. This domain has...

[ "GO:0004842", "GO:0046872", "GO:0016567" ]

[ "ubiquitin-protein transferase activity", "metal ion binding", "protein ubiquitination" ]

[ "molecular_function", "molecular_function", "biological_process" ]

3

[ "PFAM", "PROFILE" ]

[ "PF06701", "PS51416" ]

[ "MIB_HERC2", "MIB_HERC2" ]

[ 8596, 9047 ]

2

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", ...

[ "2.3.2", "R-CEL-983168", "R-DME-5693565", "R-DME-983168", "R-HSA-2122948", "R-HSA-2644606", "R-HSA-2691232", "R-HSA-2894862", "R-HSA-2979096", "R-HSA-3108214", "R-HSA-5357786", "R-HSA-5357905", "R-HSA-5693565", "R-HSA-5693571", "R-HSA-5693607", "R-HSA-69473", "R-HSA-9013507", "R-HS...

[ "EC:2.3.2", "REACTOME:R-CEL-983168", "REACTOME:R-DME-5693565", "REACTOME:R-DME-983168", "REACTOME:R-HSA-2122948", "REACTOME:R-HSA-2644606", "REACTOME:R-HSA-2691232", "REACTOME:R-HSA-2894862", "REACTOME:R-HSA-2979096", "REACTOME:R-HSA-3108214", "REACTOME:R-HSA-5357786", "REACTOME:R-HSA-5357905"...

29

[ "2dk3", "3dkm", "4xi6", "4xi7", "4xib" ]

5

[ "PUB00012800" ]

[ "12530964" ]

[ "Mind bomb is a ubiquitin ligase that is essential for efficient activation of Notch signaling by Delta." ]

[ 2003 ]

1

[]

0

null

[ "Eukaryota", "viral metagenome" ]

[ 9088, 1 ]

2

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 8, 38, 5, 22, 11, 13 ]

6

true

Domain

Mib-herc2

Mib_Herc2

5

IPR010607

10,607

Protein of unknown function DUF1194

DUF1194

Family

3,087

false

This family consists of several hypothetical Rhizobiales specific proteins of around 270 residues in length. The function of this family is unknown.

[]

0

[ "PFAM" ]

[ "PF06707" ]

[ "DUF1194" ]

[ 3087 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Methanohalobium evestigatum (strain ATCC BAA-1072 / DSM 3721 / NBRC 107634 / OCM 161 / Z-7303)", "ecological metagenomes" ]

[ 3067, 4, 1, 15 ]

4

[]

0

true

Family

Protein of unknown function DUF1194

DUF1194

8

IPR010608

10,608

Protein of unknown function DUF1195

DUF1195

Family

1,354

false

This family consists of several plant specific hypothetical proteins of around 160 residues in length. The function of this family is unknown.

[]

0

[ "PFAM", "PANTHER" ]

[ "PF06708", "PTHR34358" ]

[ "DUF1195", "" ]

[ 1354, 1329 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Tracheophyta" ]

[ 1354 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 13, 5, 14 ]

3

true

Family

Protein of unknown function DUF1195

DUF1195

8

IPR010609

10,609

Gp5, C-terminal

Gp5_C

Repeat

463

false

This repeat composes the C-terminal part of the Bacteriophage T4 baseplate protein Gp5. This region of the protein forms a needle like projection from the baseplate that is presumed to puncture the bacterial cell membrane. Structurally three copies of the repeated region trimerise to form a β solenoid type structure [ ...

[]

0

[ "PFAM" ]

[ "PF06715" ]

[ "Gp5_C" ]

[ 463 ]

1

[]

0

[ "1k28", "1pdl", "1wth", "2z6b", "3a1m", "5iv5", "6p20", "6p2a" ]

8

[ "PUB00012803", "PUB00100564" ]

[ "11823865", "21793574" ]

[ "Structure of the cell-puncturing device of bacteriophage T4.", "Screw motion regulates multiple functions of T4 phage protein gene product 5 during cell puncturing." ]

[ 2002, 2011 ]

2

[]

0

null

[ "Bacteria", "Viruses", "metagenome" ]

[ 198, 264, 1 ]

3

[]

0

true

Repeat

Gp5, C-terminal

Gp5_C

7

IPR010610

10,610

Erythromycin biosynthesis protein CIII-like, C-terminal domain

EryCIII-like_C

Domain

31,953

false

This entry represents the conserved C-terminal domain found in Erythromycin biosynthesis protein CIII (EryCIII) from Saccharopolyspora erythraea, also known as 3-alpha-mycarosylerythronolide B desosaminyl transferase, and similar bacterial proteins. EryCIII is organised into two domains, both of them with a Rossmann-li...

[]

0

[ "PFAM" ]

[ "PF06722" ]

[ "EryCIII-like_C" ]

[ 31953 ]

1

[ "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC"...

[ "2.4.1.-", "PWY-1901", "PWY-1961", "PWY-1981", "PWY-2021", "PWY-2881", "PWY-2901", "PWY-2902", "PWY-4421", "PWY-4801", "PWY-5094", "PWY-5105", "PWY-5129", "PWY-5139", "PWY-5160", "PWY-5161", "PWY-5268", "PWY-5284", "PWY-5286", "PWY-5310", "PWY-5312", "PWY-5313", "PWY-5317...

[ "EC:2.4.1.-", "METACYC:PWY-1901", "METACYC:PWY-1961", "METACYC:PWY-1981", "METACYC:PWY-2021", "METACYC:PWY-2881", "METACYC:PWY-2901", "METACYC:PWY-2902", "METACYC:PWY-4421", "METACYC:PWY-4801", "METACYC:PWY-5094", "METACYC:PWY-5105", "METACYC:PWY-5129", "METACYC:PWY-5139", "METACYC:PWY-5...

200

[ "1iir", "1pn3", "1pnv", "1rrv", "2iya", "2iyf", "2p6p", "2yjn", "3d0q", "3d0r", "3h4i", "3h4t", "3ia7", "3iaa", "3otg", "3oth", "3oti", "3rsc", "3tsa", "3uyk", "3uyl", "3wad", "3wag", "4amb", "4amg", "4an4", "4fzr", "4g2t", "4ldp", "4lei", "4m60", "4m7p"...

54

[ "PUB00074327" ]

[ "22056329" ]

[ "Structure of the glycosyltransferase EryCIII in complex with its activating P450 homologue EryCII." ]

[ 2012 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Orthornavirae", "unclassified sequences" ]

[ 8, 19586, 12281, 10, 68 ]

5

[ "Arabidopsis thaliana", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Zea mays" ]

[ 18, 4, 14, 1, 36 ]

5

true

Domain

Erythromycin biosynthesis protein CIII-like, C-terminal domain

EryCIII-like_C

9

IPR010611

10,611

3D domain

3D_dom

Domain

17,990

false

This short presumed domain contains three conserved aspartate residues, hence the name 3D. This conservation is suggestive of a cation binding function. The central aspartate is found in a DTG motif that is suggestive of a peptidase like active site [ ].

[ "GO:0004553", "GO:0009254", "GO:0019867" ]

[ "hydrolase activity, hydrolyzing O-glycosyl compounds", "peptidoglycan turnover", "outer membrane" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PFAM" ]

[ "PF06725" ]

[ "3D" ]

[ 17990 ]

1

[]

0

[ "2ae0", "2g5d", "2g6g", "2gae", "2pi8", "2pic", "2pjj", "2pnw", "3czb", "4wjt", "4wli", "4wlk", "6qk4", "7esj" ]

14

[ "PUB00033633" ]

[ "16139297" ]

[ "Crystal structure of MltA from Escherichia coli reveals a unique lytic transglycosylase fold." ]

[ 2005 ]

1

[]

[ "IPR059180" ]

0

1

0

[ "Bacteria", "Eukaryota", "Nitrosopumilaceae", "Viruses", "metagenomes" ]

[ 17608, 65, 5, 134, 178 ]

5

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Domain

3D domain

3D_dom

4

IPR010613

10,613

Pescadillo

PES

Family

5,925

false

Pescadillo (PES) protein was first identified as an essential protein for zebrafish embryonic development [ ]. It is conserved from yeasts to humans. Pescadillo homologues are involved in embryonic development and ribosome biogenesis [ , ]. It has been linked to chromosomal instability and cancer [ , ].

[ "GO:0042254", "GO:0005730" ]

[ "ribosome biogenesis", "nucleolus" ]

[ "biological_process", "cellular_component" ]

2

[ "HAMAP", "PFAM", "PANTHER" ]

[ "MF_03028", "PF06732", "PTHR12221" ]

[ "Pescadillo", "Pescadillo_N", "" ]

[ 4276, 5711, 5890 ]

3

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-CEL-6791226", "R-DDI-6791226", "R-DME-6791226", "R-HSA-6791226", "R-MMU-6791226", "R-RNO-6791226", "R-SCE-6791226", "R-SPO-6791226", "R-XTR-6791226" ]

[ "REACTOME:R-CEL-6791226", "REACTOME:R-DDI-6791226", "REACTOME:R-DME-6791226", "REACTOME:R-HSA-6791226", "REACTOME:R-MMU-6791226", "REACTOME:R-RNO-6791226", "REACTOME:R-SCE-6791226", "REACTOME:R-SPO-6791226", "REACTOME:R-XTR-6791226" ]

9

[ "2ep8", "3jct", "5z3g", "6c0f", "6cb1", "6elz", "6em1", "6em3", "6em4", "6em5", "6ft6", "6m62", "6ylx", "6yly", "7btb", "7nac", "7nad", "7ohp", "7ohq", "7ohr", "7ohs", "7ohv", "7ohw", "7ohx", "7r6q", "7r72", "7r7a", "7u0h", "7uoo", "7uqb", "7uqz", "7v08"...

86

[ "PUB00068815", "PUB00068816", "PUB00068817", "PUB00068818", "PUB00068819" ]

[ "8985183", "19075239", "17727835", "15467761", "22860098" ]

[ "Insertional mutagenesis in zebrafish identifies two novel genes, pescadillo and dead eye, essential for embryonic development.", "The Candida albicans pescadillo homolog is required for normal hypha-to-yeast morphogenesis and yeast proliferation.", "Pescadillo is required for Xenopus laevis eye development and...

[ 1996, 2008, 2007, 2004, 2012 ]

5

[]

0

null

[ "Eukaryota" ]

[ 5925 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 4, 1, 1, 1, 8, 2, 1, 1, 4, 1, 1, 18 ]

12

true

Family

Pescadillo

PES

7

IPR010614

10,614

RAD3-like helicase, DEAD

RAD3-like_helicase_DEAD

Domain

27,310

false

This domain is found in the RAD3-like DNA-binding helicase Regulator of telomere elongation helicase 1 homolog from Drosophila melanogaster (Rtel1), General transcription and DNA repair factor IIH helicase subunit XPD from Saccharomyces cerevisiae (RAD3) and similar proteins that are seemingly ubiquitous, including mem...

[ "GO:0003677", "GO:0003678", "GO:0005524" ]

[ "DNA binding", "DNA helicase activity", "ATP binding" ]

[ "molecular_function", "molecular_function", "molecular_function" ]

3

[ "PFAM" ]

[ "PF06733" ]

[ "DEAD_2" ]

[ 27310 ]

1

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", ...

[ "5.6.2.3", "R-BTA-113418", "R-BTA-5696395", "R-BTA-5696400", "R-BTA-674695", "R-BTA-6781823", "R-BTA-6782135", "R-BTA-6782210", "R-BTA-6796648", "R-BTA-72086", "R-BTA-73762", "R-BTA-73772", "R-BTA-73776", "R-BTA-73779", "R-BTA-73863", "R-BTA-75953", "R-BTA-75955", "R-BTA-76042", ...

[ "EC:5.6.2.3", "REACTOME:R-BTA-113418", "REACTOME:R-BTA-5696395", "REACTOME:R-BTA-5696400", "REACTOME:R-BTA-674695", "REACTOME:R-BTA-6781823", "REACTOME:R-BTA-6782135", "REACTOME:R-BTA-6782210", "REACTOME:R-BTA-6796648", "REACTOME:R-BTA-72086", "REACTOME:R-BTA-73762", "REACTOME:R-BTA-73772", ...

143

[ "2vl7", "2vsf", "3crv", "3crw", "4a15", "5fmf", "5h8c", "5h8w", "5ivw", "5iy6", "5iy7", "5iy8", "5iy9", "5of4", "5oqj", "5oqm", "5sva", "6fwr", "6fws", "6gym", "6nmi", "6o9l", "6o9m", "6ro4", "7ad8", "7egb", "7egc", "7ena", "7enc", "7k01", "7k04", "7lbm"...

80

[ "PUB00007684", "PUB00074118", "PUB00074223", "PUB00074225", "PUB00074226", "PUB00074228", "PUB00103976", "PUB00133413", "PUB00133415", "PUB00133416", "PUB00153326" ]

[ "10915862", "24009516", "18957201", "25628358", "24582487", "25620558", "34644293", "23329068", "19578366", "22886559", "35320499" ]

[ "Nucleotide excision repair in yeast.", "A recessive founder mutation in regulator of telomere elongation helicase 1, RTEL1, underlies severe immunodeficiency and features of Hoyeraal Hreidarsson syndrome.", "RTEL1 maintains genomic stability by suppressing homologous recombination.", "Human regulator of telo...

[ 2000, 2013, 2008, 2015, 2014, 2015, 2021, 2013, 2009, 2012, 2022 ]

11

[]

[ "IPR006554" ]

0

1

0

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 1418, 9569, 16158, 2, 163 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus",...

[ 38, 4, 24, 13, 2, 38, 14, 2, 11, 16, 2, 2, 34 ]

13

true

Domain

RAD3-like helicase, DEAD

RAD3-like_helicase_DEAD

3

IPR010615

10,615

Herpesvirus UL97

Herpes_UL97

Domain

479

false

The gene product form the gene UL97 is a serine/threonine kinase. Although it can phosphorylates the antiviral drug ganciclovir [ ], its biological function is the phosphorylation of its natural viral and cellular protein substrates which affect viral replication at many levels.

[ "GO:0004672", "GO:0005524", "GO:0016032" ]

[ "protein kinase activity", "ATP binding", "viral process" ]

[ "molecular_function", "molecular_function", "biological_process" ]

3

[ "PFAM" ]

[ "PF06734" ]

[ "UL97" ]

[ 479 ]

1

[ "REACTOME", "REACTOME" ]

[ "R-HSA-9609690", "R-HSA-9610379" ]

[ "REACTOME:R-HSA-9609690", "REACTOME:R-HSA-9610379" ]

2

[]

0

[ "PUB00012811", "PUB00045950" ]

[ "9217058", "19434630" ]

[ "The murine cytomegalovirus (MCMV) homolog of the HCMV phosphotransferase (UL97(pk)) gene.", "Function of human cytomegalovirus UL97 kinase in viral infection and its inhibition by maribavir." ]

[ 1997, 2009 ]

2

[]

0

null

[ "Homo sapiens", "Orthoherpesviridae" ]

[ 1, 478 ]

2

[ "Homo sapiens" ]

[ 1 ]

1

true

Domain

Herpesvirus UL97

Herpes_UL97

9

IPR010617

10,617

Endosomal/lysosomal proton channel TMEM175-like

TMEM175-like

Family

8,779

false

In animals, TMEM175 is an organelle-specific proton channel that catalyses proton efflux from endosomes and lysosomes to maintain a steady-state pH [ , ]. It may also act as a potassium channel at higher pH, regulating potassium conductance in endosomes and lysosomes [ , , , , ], however, this activity in unclear in vi...

[ "GO:0005267", "GO:0015252" ]

[ "potassium channel activity", "proton channel activity" ]

[ "molecular_function", "molecular_function" ]

2

[ "PFAM" ]

[ "PF06736" ]

[ "TMEM175" ]

[ 8779 ]

1

[]

0

[ "5vre", "6hd8", "6hd9", "6hda", "6hdb", "6hdc", "6swr", "6w8n", "6w8o", "6w8p", "6wc9", "6wca", "6wcb", "6wcc", "7lf6", "7unl", "7unm", "8dhm", "8fy5", "8fyf", "8vic", "8vie", "9vsp", "9vsq", "9vsr" ]

25

[ "PUB00076705", "PUB00097918", "PUB00101903", "PUB00101904", "PUB00101905", "PUB00101906", "PUB00101907" ]

[ "26317472", "32267231", "32228865", "28723891", "35750034", "33505021", "35333573" ]

[ "TMEM175 Is an Organelle K(+) Channel Regulating Lysosomal Function.", "Structural basis for ion selectivity in TMEM175 K<sup>+</sup> channels.", "Gating and selectivity mechanisms for the lysosomal K+ channel TMEM175.", "The lysosomal potassium channel TMEM175 adopts a novel tetrameric architecture.", "Par...

[ 2015, 2020, 2020, 2017, 2022, 2021, 2022 ]

7

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "metagenomes" ]

[ 243, 7230, 1225, 81 ]

4

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 9, 3, 4 ]

4

true

Family

Endosomal/lysosomal proton channel TMEM175-like

TMEM175-like

6

IPR010618

10,618

Resuscitation-promoting factor, core lysozyme-like domain

RPF

Domain

11,637

false

Resuscitation-promoting factor (RPF) proteins, found in various (G+C)-rich Gram-positive bacteria, act to reactivate cultures from stationary phase. This protein shares elements of the structural core of lysozyme and related proteins. Furthermore, it shares a conserved active site glutamate which is required for activi...

[ "GO:0016787" ]

[ "hydrolase activity" ]

[ "molecular_function" ]

1

[ "PFAM", "CDD" ]

[ "PF06737", "cd13925" ]

[ "Transglycosylas", "RPF" ]

[ 11620, 11328 ]

2

[]

0

[ "1xsf", "2n5z", "3eo5", "4cge", "4emn", "4kl7", "4kpm", "4ow1", "5e27" ]

9

[ "PUB00032509", "PUB00051748", "PUB00079510", "PUB00096306", "PUB00096307" ]

[ "15723078", "18992255", "8564539", "16359320", "24452911" ]

[ "The structure of a resuscitation-promoting factor domain from Mycobacterium tuberculosis shows homology to lysozymes.", "Crystal structure of the resuscitation-promoting factor (DeltaDUF)RpfB from M. tuberculosis.", "Chitinases, chitosanases, and lysozymes can be divided into procaryotic and eucaryotic familie...

[ 2005, 2009, 1996, 2006, 2014 ]

5

[]

0

null

[ "Bacteria", "Caudoviricetes", "Opisthokonta", "metagenomes" ]

[ 11361, 214, 9, 53 ]

4

[]

0

true

Domain

Resuscitation-promoting factor, core lysozyme-like domain

RPF

1

IPR010619

10,619

Threonine/serine exporter-like, N-terminal domain

ThrE-like_N

Domain

18,464

false

This entry represents a domain found in ThrE family members, found in bacteria, fungi and some archaeal species. ThrE is a family of proteins that catalyse the export of L-threonine from the cell [ ]. has been characterised as being necessary for this export. The domain exhibits 10 putative TMs and catalyses the proton...

[ "GO:0022857", "GO:0055085" ]

[ "transmembrane transporter activity", "transmembrane transport" ]

[ "molecular_function", "biological_process" ]

2

[ "PFAM" ]

[ "PF06738" ]

[ "ThrE" ]

[ 18464 ]

1

[]

0

[]

0

[ "PUB00075540", "PUB00075541" ]

[ "12089010", "12111147" ]

[ "Identification of glyA (encoding serine hydroxymethyltransferase) and its use together with the exporter ThrE to increase L-threonine accumulation by Corynebacterium glutamicum.", "Influence of threonine exporters on threonine production in Escherichia coli." ]

[ 2002, 2002 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "Methanobacteriota", "unclassified sequences" ]

[ 14469, 3886, 32, 77 ]

4

[ "Escherichia coli (strain K12)", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 1, 2, 2 ]

4

true

Domain

Threonine/serine exporter-like, N-terminal domain

ThrE-like_N

1

IPR010620

10,620

Seven Bladed Beta Propeller repeat

SBBP_rpt

Repeat

3,197

false

This entry, which is related to , also forms part of a β-propeller. SBBP stands for Seven Bladed Beta Propeller. Members of this group are found both in bacteria and eukaryotes, including from Cylindrospermum licheniforme [ ].

[]

0

[ "PFAM" ]

[ "PF06739" ]

[ "SBBP" ]

[ 3197 ]

1

[]

0

[ "7fh6", "7fh7", "7fh8", "7ron", "7roo" ]

5

[ "PUB00161737" ]

[ "35212625" ]

[ "Structural basis for an unprecedented enzymatic alkylation in cylindrocyclophane biosynthesis." ]

[ 2022 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Mimiviridae", "metagenomes" ]

[ 62, 2539, 408, 8, 180 ]

5

[]

0

true

Repeat

Seven Bladed Beta Propeller repeat

SBBP_rpt

8

IPR010621

10,621

Domain of unknown function DUF1214

DUF1214

Domain

11,838

false

This entry represents the domain of unknown function that is found in the C-terminal region of a number of uncharacterised bacterial proteins, as well as in other proteins.

[]

0

[ "PFAM" ]

[ "PF06742" ]

[ "DUF1214" ]

[ 11838 ]

1

[]

0

[ "2p3y", "3u07", "3vb9", "6ans" ]

4

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Imitervirales", "metagenomes" ]

[ 90, 11055, 562, 2, 129 ]

5

[]

0

true

Domain

Domain of unknown function DUF1214

DUF1214

4

IPR010622

10,622

FAST kinase leucine-rich

FAST_Leu-rich

Domain

6,562

false

This entry represents a conserved region of eukaryotic Fas-activated serine/threonine (FAST) kinases that contains several conserved leucine residues. This domain can be found in the FASTK family members, including FASTK, FASTKD1, FASTKD2 and FASTKD5. FAST kinase has been shown to be rapidly activated during Fas-mediat...

[ "GO:0044528" ]

[ "regulation of mitochondrial mRNA stability" ]

[ "biological_process" ]

1

[ "PFAM" ]

[ "PF06743" ]

[ "FAST_1" ]

[ 6562 ]

1

[ "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-6793080", "R-HSA-9837092", "R-HSA-9937008" ]

[ "REACTOME:R-HSA-6793080", "REACTOME:R-HSA-9837092", "REACTOME:R-HSA-9937008" ]

3

[ "9gek" ]

1

[ "PUB00012815", "PUB00093949", "PUB00093950", "PUB00093951" ]

[ "7544399", "25704814", "20869947", "29036396" ]

[ "Fas-activated serine/threonine kinase (FAST) phosphorylates TIA-1 during Fas-mediated apoptosis.", "A mitochondria-specific isoform of FASTK is present in mitochondrial RNA granules and regulates gene expression and function.", "Fast kinase domain-containing protein 3 is a mitochondrial protein essential for c...

[ 1995, 2015, 2010, 2017 ]

4

[]

0

null

[ "Eukaryota" ]

[ 6562 ]

1

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 9, 2, 19, 16, 24 ]

5

true

Domain

FAST kinase leucine-rich

FAST_Leu-rich

8

IPR010623

10,623

Type VI secretion system IcmF, C-terminal

IcmF_C

Domain

8,338

false

This entry represents a conserved region situated towards the C-terminal end of IcmF-like proteins. IcmF was thought to be involved in Vibrio cholerae cell surface reorganisation that results in increased adherence to epithelial cells leading to an increased conjugation frequency [ ]. IcmF as a whole interacts with Dot...

[]

0

[ "PFAM" ]

[ "PF06744" ]

[ "IcmF_C" ]

[ 8338 ]

1

[]

0

[ "4y7l", "4y7m", "4y7o", "6hs7", "6ixh" ]

5

[ "PUB00012816", "PUB00075434" ]

[ "12127983", "24381728" ]

[ "Involvement of in vivo induced icmF gene of Vibrio cholerae in motility, adherence to epithelial cells, and conjugation frequency.", "The rise of the Type VI secretion system." ]

[ 2002, 2013 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 8283, 6, 49 ]

3

[]

0

true

Domain

Type VI secretion system IcmF, C-terminal

IcmF_C

9

IPR010624

10,624

KaiC domain

KaiC_dom

Domain

7,646

false

This entry represents a domain found in bacterial proteins related to Circadian clock oscillator protein KaiC and archaeal uncharacterised sequences belonging to the UPF0273 family. More than one copy is sometimes found in each protein in this group. KaiC is one of the Kai proteins among which direct protein-protein as...

[ "GO:0005524" ]

[ "ATP binding" ]

[ "molecular_function" ]

1

[ "PROFILE" ]

[ "PS51146" ]

[ "KAIC" ]

[ 7646 ]

1

[ "PROSITEDOC" ]

[ "PDOC51146" ]

[ "PROSITEDOC:PDOC51146" ]

1

[ "1tf7", "1u9i", "2dr3", "2gbl", "2w0m", "2zts", "3dvl", "3jzm", "3k09", "3k0a", "3k0c", "3k0e", "3k0f", "3s1a", "4dug", "4ijm", "4o0m", "4tl6", "4tl7", "4tl8", "4tl9", "4tla", "4tlb", "4tlc", "4tld", "4tle", "5jwo", "5jwq", "5jwr", "5n8y", "5yz8", "6x61"...

59

[ "PUB00012817", "PUB00102259" ]

[ "10064581", "19913541" ]

[ "Physical interactions among circadian clock proteins KaiA, KaiB and KaiC in cyanobacteria.", "The molecular clockwork of a protein-based circadian oscillator." ]

[ 1999, 2009 ]

2

[ "IPR014774" ]

[ "IPR047221", "IPR047222" ]

1

2

0

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 2439, 5153, 4, 50 ]

4

[]

0

true

Domain

KaiC domain

KaiC_dom

9

IPR010625

10,625

CHCH

Domain

11,922

false

A conserved motif was identified in the LOC118487 protein was called the CHCH motif. Alignment of this protein with related members showed the presence of three subgroups of proteins, which are called the S (Small), N (N-terminal extended) and C (C-terminal extended) subgroups. All three sub-groups of proteins have in ...

[]

0

[ "PFAM" ]

[ "PF06747" ]

[ "CHCH" ]

[ 11922 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-611105", "R-BTA-6799198", "R-BTA-9864848", "R-HSA-1268020", "R-HSA-5368286", "R-HSA-5389840", "R-HSA-5419276", "R-HSA-611105", "R-HSA-6799198", "R-HSA-9837999", "R-HSA-9864848", "R-HSA-9937383", "R-MMU-5389840", "R-MMU-5419276", "R-MMU-611105", "R-MMU-6799198", "R-MMU-9864848"...

[ "REACTOME:R-BTA-611105", "REACTOME:R-BTA-6799198", "REACTOME:R-BTA-9864848", "REACTOME:R-HSA-1268020", "REACTOME:R-HSA-5368286", "REACTOME:R-HSA-5389840", "REACTOME:R-HSA-5419276", "REACTOME:R-HSA-611105", "REACTOME:R-HSA-6799198", "REACTOME:R-HSA-9837999", "REACTOME:R-HSA-9864848", "REACTOME:...

18

[ "2k3j", "2l0y", "2lql", "2zxt", "3a3c", "3j9m", "3jd5", "5aj3", "5aj4", "5gpn", "5gup", "5lc5", "5ldw", "5ldx", "5lnk", "5mrc", "5mre", "5mrf", "5o31", "5xtc", "5xtd", "5xth", "5xti", "6g2j", "6g72", "6gaw", "6gaz", "6gcs", "6neq", "6nf8", "6nu2", "6nu3"...

331

[ "PUB00010187", "PUB00011388", "PUB00019294" ]

[ "9065385", "9860297", "15177562" ]

[ "Cloning and characterization of MRP10, a yeast gene coding for a mitochondrial ribosomal protein.", "The nuclear-encoded human NADH:ubiquinone oxidoreductase NDUFA8 subunit: cDNA cloning, chromosomal localization, tissue distribution, and mutation detection in complex-I-deficient patients.", "C2360, a nuclear ...

[ 1997, 1998, 2004 ]

3

[]

0

null

[ "Bacteria", "Eukaryota" ]

[ 2, 11920 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 33, 6, 3, 11, 14, 19, 2, 5, 38, 4, 4, 30 ]

12

true

Domain

CHCH

8

IPR010626

10,626

Protein of unknown function DUF1217

DUF1217

Family

1,941

false

This family represents a conserved region that is found within bacterial proteins, most of which are hypothetical. Some members contain multiple copies.

[]

0

[ "PFAM" ]

[ "PF06748" ]

[ "DUF1217" ]

[ 1941 ]

1

[]

0

[ "2o8s" ]

1

[]

0

[]

0

null

[ "Pseudomonadota", "Ricinus communis", "ecological metagenomes" ]

[ 1931, 1, 9 ]

3

[]

0

true

Family

Protein of unknown function DUF1217

DUF1217

9

IPR010627

10,627

Prepilin peptidase A24, N-terminal

Prepilin_pept_A24_N

Domain

14,264

false

This domain is found at the N terminus of the prepilin peptidases. Members included in this entry have been characterised as bifunctional [ ], and this domain may contain the N-methylation activity ([ec:2.1.1.-]). It consists of an intracellular region between a pair of transmembrane sections. This region contains an i...

[]

0

[ "PFAM" ]

[ "PF06750" ]

[ "A24_N_bact" ]

[ 14264 ]

1

[ "EC", "EC", "GP", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METAC...

[ "2.1.1.-", "3.4.23.43", "GenProp0295", "PWY-1061", "PWY-2083", "PWY-3542", "PWY-4021", "PWY-4161", "PWY-4202", "PWY-5059", "PWY-5105", "PWY-5301", "PWY-5305", "PWY-5479", "PWY-5665", "PWY-5729", "PWY-5748", "PWY-5765", "PWY-5773", "PWY-5846", "PWY-5883", "PWY-5975", "PWY-...

[ "EC:2.1.1.-", "EC:3.4.23.43", "GP:GenProp0295", "METACYC:PWY-1061", "METACYC:PWY-2083", "METACYC:PWY-3542", "METACYC:PWY-4021", "METACYC:PWY-4161", "METACYC:PWY-4202", "METACYC:PWY-5059", "METACYC:PWY-5105", "METACYC:PWY-5301", "METACYC:PWY-5305", "METACYC:PWY-5479", "METACYC:PWY-5665", ...

148

[]

0

[ "PUB00012818", "PUB00012819", "PUB00100343" ]

[ "8057924", "8340405", "23255525" ]

[ "Posttranslational processing of type IV prepilin and homologs by PilD of Pseudomonas aeruginosa.", "Identification of active-site cysteines in the conserved domain of PilD, the bifunctional type IV pilin leader peptidase/N-methyltransferase of Pseudomonas aeruginosa.", "Cell-free production of integral membran...

[ 1994, 1993, 2013 ]

3

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 13999, 15, 250 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Domain

Prepilin peptidase A24, N-terminal

Prepilin_pept_A24_N

5

IPR010628

10,628

Ethanolamine ammonia-lyase heavy chain

EutB

Family

6,536

false

This family consists of several bacterial ethanolamine ammonia-lyase heavy chain (EutB) (also known as ethanolamine ammonia lyase large subunit and ethanolamine ammonia-lyase alpha subunit) proteins. Ethanolamine ammonia-lyase is a bacterial enzyme that catalyses the adenosylcobalamin-dependent conversion of certain vi...

[ "GO:0008851", "GO:0006520" ]

[ "ethanolamine ammonia-lyase activity", "amino acid metabolic process" ]

[ "molecular_function", "biological_process" ]

2

[ "HAMAP", "NCBIFAM", "PFAM", "PIRSF", "PANTHER" ]

[ "MF_00861", "NF011649", "PF06751", "PIRSF018788", "PTHR39329" ]

[ "EutB", "PRK15067.1", "EutB", "EutB", "" ]

[ 6006, 6166, 6536, 5860, 6524 ]

5

[ "EC", "GP", "GP", "GP", "GP" ]

[ "4.3.1.7", "GenProp0292", "GenProp0294", "GenProp1167", "GenProp1762" ]

[ "EC:4.3.1.7", "GP:GenProp0292", "GP:GenProp0294", "GP:GenProp1167", "GP:GenProp1762" ]

5

[ "2qez", "3abo", "3abq", "3abr", "3abs", "3any", "3ao0", "5ysn", "5ysr", "7xrm", "7xrn" ]

11

[ "PUB00002563", "PUB00097599" ]

[ "2197274", "20519496" ]

[ "Cloning, sequencing, and expression of the genes encoding the adenosylcobalamin-dependent ethanolamine ammonia-lyase of Salmonella typhimurium.", "Crystal structures of ethanolamine ammonia-lyase complexed with coenzyme B12 analogs and substrates." ]

[ 1990, 2010 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "Halobacteriales", "metagenomes" ]

[ 6451, 15, 30, 40 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Ethanolamine ammonia-lyase heavy chain

EutB

3

IPR010629

10,629

Insect allergen-related

Ins_allergen

Family

1,112

false

This family exemplifies a case of novel gene evolution. The case in point is the arms-race between plants and their infective insective herbivores in the area of the glucosinolate-myrosinase system. Brassicas have developed the glucosinolate-myrosinase system as chemical defence mechanism against the insects, and conse...

[]

0

[ "PFAM", "PANTHER" ]

[ "PF06757", "PTHR21163" ]

[ "Ins_allergen_rp", "" ]

[ 1112, 1018 ]

2

[]

0

[ "4jrb", "6xrx" ]

2

[ "PUB00053703" ]

[ "18296701" ]

[ "Evolutionary origins of a novel host plant detoxification gene in butterflies." ]

[ 2008 ]

1

[]

0

null

[ "Eukaryota", "Phocaeicola vulgatus", "viral metagenome" ]

[ 1110, 1, 1 ]

3

[ "Drosophila melanogaster" ]

[ 11 ]

1

true

Family

Insect allergen-related

Ins_allergen

6

IPR010630

10,630

Olduvai domain

Olduvai_dom

Domain

2,031

false

Proteins of the neuroblastoma breakpoint family (NBPF) contain a highly conserved domain of unknown function, which is known as NBPF, also known as Olduvai [ ] or DUF1220 [ ]. The NBPF/DUF1220 domain is present in multiple copies in NBPF proteins and once, with lower homology, in mammalian myomegalin, a protein localis...

[]

0

[ "PFAM", "PROFILE", "SMART" ]

[ "PF06758", "PS51316", "SM01148" ]

[ "Olduvai", "ODV", "DUF1220" ]

[ 1546, 1820, 2017 ]

3

[]

0

[]

0

[ "PUB00043671", "PUB00043672", "PUB00053867", "PUB00077271", "PUB00077272", "PUB00077275" ]

[ "16079250", "16946073", "19850849", "26112965", "25758905", "25287832" ]

[ "A novel gene family NBPF: intricate structure generated by gene duplications during primate evolution.", "Human lineage-specific amplification, selection, and neuronal expression of DUF1220 domains.", "DUF1220 Domains, Cognitive Disease, and Human Brain Evolution.", "Phylogenetic Analysis Supports a Link bet...

[ 2005, 2006, 2009, 2015, 2015, 2015 ]

6

[]

0

null

[ "Bilateria" ]

[ 2031 ]

1

[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 123, 5, 15 ]

3

true

Domain

Olduvai domain

Olduvai_dom

3

IPR010632

10,632

Domain of unknown function DUF1221

DUF1221

Domain

1,050

false

This is a group of plant proteins, most of which are hypothetical and of unknown function. All members contain the domain, suggesting that they may possess kinase activity.

[]

0

[ "PFAM" ]

[ "PF06760" ]

[ "DUF1221" ]

[ 1050 ]

1

[]

0

[ "6ka4", "6lba" ]

2

[]

0

[]

0

null

[ "Embryophyta" ]

[ 1050 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 11, 4, 7 ]

3

true

Domain

Domain of unknown function DUF1221

DUF1221

8

IPR010633

10,633

Bacteriophage lambda, GpZ, minor tail

Phage_lambda_GpZ

Family

1,826

false

This family is represented by bacteriopage lambda GpZ, the minor tail protein. The characteristics of the protein distribution suggest prophage matches in addition to the phage matches.

[]

0

[ "PFAM", "PIRSF" ]

[ "PF06763", "PIRSF004395" ]

[ "Minor_tail_Z", "Tail_Z" ]

[ 1826, 1013 ]

2

[ "GP" ]

[ "GenProp0208" ]

[ "GP:GenProp0208" ]

1

[]

0

[]

0

[]

0

null

[ "Bacteria", "Opisthokonta", "Viruses", "metagenomes" ]

[ 1751, 6, 54, 15 ]

4

[]

0

true

Family

Bacteriophage lambda, GpZ, minor tail

Phage_lambda_GpZ

7

IPR010634

10,634

Protein of unknown function DUF1223

DUF1223

Family

4,574

false

This family consists of several hypothetical proteins of around 250 residues in length, which are found in both plants and bacteria. The function of this family is unknown.

[]

0

[ "PFAM", "PANTHER" ]

[ "PF06764", "PTHR36057" ]

[ "DUF1223", "" ]

[ 4569, 4518 ]

2

[]

0

[ "2axo" ]

1

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "ecological metagenomes" ]

[ 3552, 992, 30 ]

3

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 8, 2, 7 ]

3

true

Family

Protein of unknown function DUF1223

DUF1223

2

IPR010635

10,635

Heparan sulphate 6-sulfotransferase/Protein-tyrosine sulfotransferase

Heparan_SO4-6-sulfoTrfase

Family

5,458

false

This family consists of several heparan sulphate 6-sulphotransferase (HS6ST) proteins. Heparan sulphate 6-O-sulphotransferase (HS6ST) catalyses the transfer of sulphate from adenosine 3'-phosphate, 5'-phosphosulphate to the 6th position of the N-sulphoglucosamine residue in heparan sulphate [ ]. This entry also include...

[ "GO:0008146", "GO:0016020" ]

[ "sulfotransferase activity", "membrane" ]

[ "molecular_function", "cellular_component" ]

2

[ "PANTHER" ]

[ "PTHR12812" ]

[ "" ]

[ 5458 ]

1

[ "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "2.8.2.-", "PWY-6546", "PWY-6558", "PWY-6567", "PWY-6568", "PWY-7831", "PWY-8045", "PWY-8358", "PWY-8381", "R-DRE-2022928", "R-GGA-2022928", "R-HSA-2022928", "R-MMU-2022928" ]

[ "EC:2.8.2.-", "METACYC:PWY-6546", "METACYC:PWY-6558", "METACYC:PWY-6567", "METACYC:PWY-6568", "METACYC:PWY-7831", "METACYC:PWY-8045", "METACYC:PWY-8358", "METACYC:PWY-8381", "REACTOME:R-DRE-2022928", "REACTOME:R-GGA-2022928", "REACTOME:R-HSA-2022928", "REACTOME:R-MMU-2022928" ]

13

[ "5t03", "5t05", "5t0a" ]

3

[ "PUB00012826", "PUB00067992" ]

[ "12492399", "19666544" ]

[ "Biosynthesis of heparan sulphate with diverse structures and functions: two alternatively spliced forms of human heparan sulphate 6-O-sulphotransferase-2 having different expression patterns and properties.", "Identification of tyrosylprotein sulfotransferase in Arabidopsis." ]

[ 2003, 2009 ]

2

[ "IPR005331" ]

[]

1

0

1

[ "Bacteria", "Eukaryota", "Nitrososphaeria", "Viruses", "ecological metagenomes" ]

[ 264, 5182, 2, 3, 7 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 6, 1, 11, 2, 10, 5, 3, 11, 26 ]

9

true

Family

Heparan sulphate 6-sulfotransferase/Protein-tyrosine sulfotransferase

Heparan_SO4-6-sulfoTrfase

7

IPR010636

10,636

Class II hydrophobin

Class_II_hydrophobin

Family

1,858

false

This entry represents Class II hydrophobins and related fungal proteins, particularly ascomycetes. Hydrophobins are small, moderately hydrophobic extracellular proteins characterised by eight cysteine residues arranged in a strictly conserved motif. They are typically found on the outer surface of conidia and the hypha...

[ "GO:0005576" ]

[ "extracellular region" ]

[ "cellular_component" ]

1

[ "PFAM", "PANTHER", "CDD" ]

[ "PF06766", "PTHR42341", "cd23508" ]

[ "Hydrophobin_2", "", "hydrophobin_II" ]

[ 1854, 1549, 1776 ]

3

[]

0

[ "1r2m", "2b97", "2fz6", "2gvm", "2pl6", "2pl7", "3qqt", "4aog", "4bwh" ]

9

[ "PUB00012827", "PUB00059146", "PUB00059147", "PUB00089655", "PUB00160789" ]

[ "11343402", "10584000", "9344630", "10336622", "3080312" ]

[ "The hydrophobin HCf-1 of Cladosporium fulvum is required for efficient water-mediated dispersal of conidia.", "Secretion of cryparin, a fungal hydrophobin.", "Cerato-ulmin, a hydrophobin secreted by the causal agents of Dutch elm disease, is a parasitic fitness factor.", "Identification and characterization ...

[ 2001, 1999, 1997, 1999, 1986 ]

5

[]

0

null

[ "Eukaryota" ]

[ 1858 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)" ]

[ 1 ]

1

true

Family

Class II hydrophobin

Class_II_hydrophobin

4

IPR010637

10,637

Sif

Family

2,203

false

This family consists of several SifA and SifB and SseJ proteins. They are effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. SifA, SifB and SseJ have been demonstrated to localise to the Salmonella-containing vacuole (SCV) and to Salmonella-induced filaments (Sifs)....

[]

0

[ "PFAM" ]

[ "PF06767" ]

[ "Sif" ]

[ 2203 ]

1

[]

0

[ "3cxb", "3hw2" ]

2

[ "PUB00012828" ]

[ "12496192" ]

[ "The Salmonella enterica serovar typhimurium translocated effectors SseJ and SifB are targeted to the Salmonella-containing vacuole." ]

[ 2003 ]

1

[]

0

null

[ "Enterobacterales" ]

[ 2203 ]

1

[]

0

true

Family

Sif

7

IPR010639

10,639

Actin-rearrangement-inducing factor

Actin-rearrang-inducing_fac

Family

112

false

This family consists of several Nucleopolyhedrovirus actin-rearrangement-inducing factor (Arif-1) proteins. In response to Autographa californica nuclear polyhedrosis virus (AcMNPV) infection, a sequential rearrangement of the actin cytoskeleton occurs this is induced by Arif-1 [ ]. Arif-1 is tyrosine phosphorylated an...

[]

0

[ "PFAM" ]

[ "PF06770" ]

[ "Arif-1" ]

[ 112 ]

1

[]

0

[]

0

[ "PUB00012830", "PUB00012831" ]

[ "9311884", "11264366" ]

[ "Identification of the early actin-rearrangement-inducing factor gene, arif-1, from Autographa californica multicapsid nuclear polyhedrosis virus.", "Actin rearrangement-inducing factor of baculoviruses is tyrosine phosphorylated and colocalizes to F-actin at the plasma membrane." ]

[ 1997, 2001 ]

2

[]

0

null

[ "Alphabaculovirus" ]

[ 112 ]

1

[]

0

true

Family

Actin-rearrangement-inducing factor

Actin-rearrang-inducing_fac

8

IPR010640

10,640

Low temperature requirement A

Low_temperature_requirement_A

Family

12,204

false

This entry consists of several bacteria specific low temperature requirement A (LtrA) protein sequences which have been found to be essential for growth at low temperatures in Listeria monocytogenes [ ]. It also contains a number of uncharacterised fungal proteins.

[]

0

[ "PFAM", "PANTHER" ]

[ "PF06772", "PTHR36840" ]

[ "LtrA", "" ]

[ 12162, 10329 ]

2

[]

0

[]

0

[ "PUB00012833" ]

[ "8534098" ]

[ "Differentiation of epidemic-associated strains of Listeria monocytogenes by restriction fragment length polymorphism in a gene region essential for growth at low temperatures (4 degrees C)." ]

[ 1995 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "Methanobacteriota", "metagenomes" ]

[ 9140, 2964, 52, 48 ]

4

[]

0

true

Family

Low temperature requirement A

Low_temperature_requirement_A

6

IPR010642

10,642

Invasion protein B

Invasion_prot_B

Family

7,406

false

This family consists of several invasion associated locus B (IalB) proteins and related sequences. IalB is known to be a major virulence factor in Bartonella bacilliformis where it was shown to have a direct role in human erythrocyte parasitism. IalB is up-regulated in response to environmental cues signalling vector-t...

[]

0

[ "PFAM" ]

[ "PF06776" ]

[ "IalB" ]

[ 7406 ]

1

[]

0

[ "3dtd" ]

1

[ "PUB00012835" ]

[ "12668141" ]

[ "Differential expression of the invasion-associated locus B (ialB) gene of Bartonella bacilliformis in response to environmental cues." ]

[ 2003 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences", "uncultured Caudovirales phage" ]

[ 7338, 10, 57, 1 ]

4

[]

0

true

Family

Invasion protein B

Invasion_prot_B

6

IPR010643

10,643

Helical and beta-bridge domain

HBB

Domain

4,687

false

HBB is the domain on DEAD-box eukaryotic DNA repair helicases ([ec:3.6.1.-]) that appears to be a unique fold. It's conformation is of α-helices 12-16 plus a short β-bridge to the FeS-cluster domain at the N-terminal. The full-length XPD protein verifies the presence of damage to DNA and allows DNA repair to proceed. X...

[]

0

[ "PFAM" ]

[ "PF06777" ]

[ "HBB" ]

[ 4687 ]

1

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", ...

[ "5.6.2.3", "R-BTA-113418", "R-BTA-5696395", "R-BTA-5696400", "R-BTA-674695", "R-BTA-6781823", "R-BTA-6782135", "R-BTA-6782210", "R-BTA-6796648", "R-BTA-72086", "R-BTA-73762", "R-BTA-73772", "R-BTA-73776", "R-BTA-73779", "R-BTA-73863", "R-BTA-75953", "R-BTA-75955", "R-BTA-76042", ...

[ "EC:5.6.2.3", "REACTOME:R-BTA-113418", "REACTOME:R-BTA-5696395", "REACTOME:R-BTA-5696400", "REACTOME:R-BTA-674695", "REACTOME:R-BTA-6781823", "REACTOME:R-BTA-6782135", "REACTOME:R-BTA-6782210", "REACTOME:R-BTA-6796648", "REACTOME:R-BTA-72086", "REACTOME:R-BTA-73762", "REACTOME:R-BTA-73772", ...

110

[ "2vsf", "4a15", "5fmf", "5h8w", "5ivw", "5iy6", "5iy7", "5iy8", "5iy9", "5of4", "5oqj", "5oqm", "5sva", "6gym", "6nmi", "6o9l", "6o9m", "6ro4", "6tun", "7ad8", "7egb", "7egc", "7ena", "7enc", "7k01", "7k04", "7lbm", "7m2u", "7ml0", "7ml1", "7ml2", "7ml3"...

75

[ "PUB00049879" ]

[ "18578568" ]

[ "Crystal structure of the FeS cluster-containing nucleotide excision repair helicase XPD." ]

[ 2008 ]

1

[]

0

null

[ "Archaea", "Eukaryota", "metagenomes" ]

[ 78, 4601, 8 ]

3

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 4, 1, 1, 7, 9, 6, 1, 2, 4, 1, 1, 7 ]

12

true

Domain

Helical and beta-bridge domain

HBB

4

IPR010644

10,644

Heme-dependent peroxidase ChdC/CLD

ChdC/CLD

Family

7,625

false

Proteins in this family are heme-dependent peroxidases, including coproheme decarboxylase (ChdC, also known as HemQ) and chlorite dismutase (CLD). Coproheme decarboxylases (ChdC) catalyze the hydrogen peroxide-mediated conversion of coproheme to heme b [ ]. Its structure has been revealed [ , ]. Chlorite dismutase cata...

[ "GO:0016491", "GO:0020037" ]

[ "oxidoreductase activity", "heme binding" ]

[ "molecular_function", "molecular_function" ]

2

[ "PFAM", "PANTHER" ]

[ "PF06778", "PTHR36843" ]

[ "Chlor_dismutase", "" ]

[ 7623, 7180 ]

2

[ "EC", "GP" ]

[ "1.3.98.5", "GenProp1663" ]

[ "EC:1.3.98.5", "GP:GenProp1663" ]

2

[ "1t0t", "1vdh", "2vxh", "3dtz", "3nn1", "3nn2", "3nn3", "3nn4", "3q08", "3q09", "3qpi", "4m05", "4m06", "4m07", "4m08", "4m09", "4wws", "5a12", "5a13", "5k8z", "5k90", "5k91", "5loq", "5mau", "5nku", "5nkv", "5t2k", "6fxj", "6fxq", "6vsa", "6vsc", "6xub"...

53

[ "PUB00012836", "PUB00053946", "PUB00094248", "PUB00094249", "PUB00094250" ]

[ "8929278", "20386942", "29536725", "27758026", "31423350" ]

[ "Purification and characterization of chlorite dismutase: a novel oxygen-generating enzyme.", "Structural features promoting dioxygen production by Dechloromonas aromatica chlorite dismutase.", "Insights into the Active Site of Coproheme Decarboxylase from Listeria monocytogenes.", "Hydrogen peroxide-mediated...

[ 1996, 2010, 2018, 2016, 2019 ]

5

[]

[ "IPR031332" ]

0

1

0

[ "Archaea", "Bacteria", "Eukaryota", "Sym plasmid", "metagenomes" ]

[ 480, 7007, 22, 1, 115 ]

5

[]

0

true

Family

Heme-dependent peroxidase ChdC/CLD

ChdC/CLD

8

IPR010645

10,645

Putative MFS transporter YjiJ

MFS_4

Family

8,455

false

This entry represents a group of putative bacterial membrane proteins which may be sugar transporters. Members carry twelve transmembrane regions which are characteristic of members of the major facilitator sugar-transporter superfamily.

[]

0

[ "PFAM", "PANTHER" ]

[ "PF06779", "PTHR23537" ]

[ "MFS_4", "" ]

[ 8095, 8140 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 58, 8319, 12, 66 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Putative MFS transporter YjiJ

MFS_4

9

IPR010646

10,646

Uncharacterised protein family UPF0257

UPF0257

Family

1,117

false

This is a group of proteins of unknown function.

[ "GO:0005886" ]

[ "plasma membrane" ]

[ "cellular_component" ]

1

[ "HAMAP", "NCBIFAM", "PFAM" ]

[ "MF_01065", "NF002798", "PF06788" ]

[ "UPF0257", "PRK02939.1", "UPF0257" ]

[ 914, 925, 1116 ]

3

[]

0

[]

0

[]

0

[]

0

null

[ "Beauveria bassiana D1-5", "Gammaproteobacteria", "human gut metagenome" ]

[ 2, 1113, 2 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Uncharacterised protein family UPF0257

UPF0257

7

IPR010648

10,648

Uncharacterised protein family UPF0270

UPF0270

Family

3,297

false

There is currently no experimental data for members of this group or their homologues, nor do they exhibit features indicative of any function. Members are mainly found in clostridia.

[]

0

[ "HAMAP", "PFAM", "PIRSF" ]

[ "MF_00690", "PF06794", "PIRSF006169" ]

[ "UPF0270", "UPF0270", "UCP006169" ]

[ 2047, 3297, 2661 ]

3

[]

0

[ "1y0n" ]

1

[]

0

[]

0

null

[ "Arthropoda", "Bacteria", "metagenomes", "uncultured Caudovirales phage" ]

[ 2, 3272, 22, 1 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Uncharacterised protein family UPF0270

UPF0270

5

IPR010650

10,650

PrkA, C-terminal domain

PrkA_C

Domain

8,092

false

This entry represents the C-terminal domain in PrkA proteins. ATP-dependent protease PrkA proteins are bacterial and archaeal serine kinases, approximately 630 residues in length. They possesses the A-motif of nucleotide-binding proteins and exhibit distant homology to eukaryotic protein kinases [ ].

[]

0

[ "PFAM" ]

[ "PF06798" ]

[ "PrkA" ]

[ 8092 ]

1

[ "EC" ]

[ "2.7.11.1" ]

[ "EC:2.7.11.1" ]

1

[]

0

[ "PUB00012839" ]

[ "8626065" ]

[ "Cloning and characterization of the Bacillus subtilis prkA gene encoding a novel serine protein kinase." ]

[ 1996 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "Methanobacteriota", "unclassified sequences", "uncultured marine phage" ]

[ 7421, 13, 596, 61, 1 ]

5

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Domain

PrkA, C-terminal domain

PrkA_C

5

IPR010651

10,651

Sugar transport protein

Sugar_transport

Family

6,193

false

This is a family of bacterial sugar transporters approximately 300 residues long. Members include glucose uptake proteins [ ], ribose transport proteins, and several putative and hypothetical membrane proteins probably involved in sugar transport across bacterial membranes.

[ "GO:0015144", "GO:0034219", "GO:0016020" ]

[ "carbohydrate transmembrane transporter activity", "carbohydrate transmembrane transport", "membrane" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PFAM", "PANTHER" ]

[ "PF06800", "PTHR16119" ]

[ "Sugar_transport", "" ]

[ 2812, 6060 ]

2

[]

0

[]

0

[ "PUB00012840" ]

[ "10438764" ]

[ "Identification of a gene in Staphylococcus xylosus encoding a novel glucose uptake protein." ]

[ 1999 ]

1

[]

[ "IPR012435" ]

0

1

0

[ "Archaea", "Bacteria", "Eukaryota", "Marseillevirus LCMAC202", "metagenomes" ]

[ 5, 3138, 3028, 1, 21 ]

5

[ "Caenorhabditis elegans", "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 7, 4, 8, 2, 3 ]

5

true

Family

Sugar transport protein

Sugar_transport

3

IPR010652

10,652

Domain of unknown function DUF1232

DUF1232

Domain

15,238

false

This domain can be found in RNF170 from eukaryotes and some uncharacterised proteins from bacteria and archaea. RNF170 is an E3 ubiquitin-protein ligase that plays an essential role in stimulus-induced inositol 1,4,5-trisphosphate receptor type 1 (ITPR1) ubiquitination and degradation via the endoplasmic reticulum-asso...

[]

0

[ "PFAM" ]

[ "PF06803" ]

[ "DUF1232" ]

[ 15238 ]

1

[ "EC", "METACYC" ]

[ "2.3.2.27", "PWY-7511" ]

[ "EC:2.3.2.27", "METACYC:PWY-7511" ]

2

[]

0

[ "PUB00078360" ]

[ "21610068" ]

[ "RNF170 protein, an endoplasmic reticulum membrane ubiquitin ligase, mediates inositol 1,4,5-trisphosphate receptor ubiquitination and degradation." ]

[ 2011 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 102, 13007, 1998, 131 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 10, 1, 1, 1, 1, 2, 3, 2 ]

8

true

Domain

Domain of unknown function DUF1232

DUF1232

6

IPR010653

10,653

Outer membrane protein assembly factor BamC-like

BamC-like

Family

5,818

false

Outer membrane protein (OMP) assembly factor BamC is part of the outer membrane protein assembly Bam complex (composed of the outer membrane protein BamA, and four lipoproteins BamB, BamC, BamD and BamE), which is involved in assembly and insertion of β-barrel proteins into the outer membrane [ , , , , ]. E. coli BamC ...

[]

0

[ "PFAM" ]

[ "PF06804" ]

[ "Lipoprotein_18" ]

[ 5818 ]

1

[ "GP", "REACTOME" ]

[ "GenProp0725", "R-HSA-9760173" ]

[ "GP:GenProp0725", "REACTOME:R-HSA-9760173" ]

2

[ "2lae", "2laf", "2yh5", "2yh6", "3sns", "3tgo", "5ayw", "5d0o", "5d0q", "5ekq", "5ljo", "6lyq", "6lyr", "6lys", "6lyu", "6smx", "6sn0", "6sn2", "6sn3", "6sn4", "6sn5", "6sn7", "6sn8", "6sn9", "6so7", "6so8", "6soa", "6sob", "6soc", "6sog", "6soh", "6soj"...

93

[ "PUB00043080", "PUB00059811", "PUB00060769", "PUB00060770", "PUB00060771", "PUB00060776" ]

[ "16824102", "21586578", "20378773", "21823654", "22281737", "22178970" ]

[ "YfiO stabilizes the YaeT complex and is essential for outer membrane protein assembly in Escherichia coli.", "Structural basis of outer membrane protein biogenesis in bacteria.", "Reconstitution of outer membrane protein assembly from purified components.", "The reconstituted Escherichia coli Bam complex cat...

[ 2006, 2011, 2010, 2011, 2012, 2012 ]

6

[]

[ "IPR014524" ]

0

1

0

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 5740, 10, 68 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Outer membrane protein assembly factor BamC-like

BamC-like

1

IPR010654

10,654

Bacteriophage lambda tail assembly I

Phage_lambda_tail_I

Family

2,484

false

This family consists of several Bacteriophage lambda tail assembly protein I and related phage and bacterial sequences [ ]. Members of this family are typically around 200 residues in length.

[]

0

[ "PFAM" ]

[ "PF06805" ]

[ "Lambda_tail_I" ]

[ 2484 ]

1

[ "GP" ]

[ "GenProp0208" ]

[ "GP:GenProp0208" ]

1

[ "8iyk", "8iyl", "8k35", "8xcg", "9l9p" ]

5

[ "PUB00077057" ]

[ "1003470" ]

[ "Morphogenesis of bacteriophage lambda tail. Polymorphism in the assembly of the major tail protein." ]

[ 1976 ]

1

[]

0

null

[ "Bacteria", "Trichuris trichiura", "Viruses", "organismal metagenomes" ]

[ 2154, 1, 324, 5 ]

4

[]

0

true

Family

Bacteriophage lambda tail assembly I

Phage_lambda_tail_I

6

IPR010655

10,655

Clp1, C-terminal

Clp1_C

Domain

4,270

false

This entry represents the C-terminal domain of Clp1. Polyribonucleotide 5-hydroxyl-kinase Clp1 is a component of the cleavage factor IA (CF IA) complex, which is involved in the endonucleolytic cleavage during polyadenylation-dependent pre-mRNA 3'-end formation [ ]. It is involved in both the endonucleolyitc cleavage a...

[ "GO:0031124" ]

[ "mRNA 3'-end processing" ]

[ "biological_process" ]

1

[ "PFAM" ]

[ "PF06807" ]

[ "Clp1" ]

[ 4270 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-72187", "R-BTA-72203", "R-BTA-73856", "R-BTA-77595", "R-CEL-72187", "R-CEL-72203", "R-CEL-73856", "R-CEL-77595", "R-DME-72187", "R-DME-72203", "R-DME-73856", "R-DME-77595", "R-GGA-72187", "R-GGA-73856", "R-GGA-77595", "R-HSA-6784531", "R-HSA-72187", "R-HSA-72203", "R-HSA-7...

[ "REACTOME:R-BTA-72187", "REACTOME:R-BTA-72203", "REACTOME:R-BTA-73856", "REACTOME:R-BTA-77595", "REACTOME:R-CEL-72187", "REACTOME:R-CEL-72203", "REACTOME:R-CEL-73856", "REACTOME:R-CEL-77595", "REACTOME:R-DME-72187", "REACTOME:R-DME-72203", "REACTOME:R-DME-73856", "REACTOME:R-DME-77595", "REA...

28

[ "2npi", "4c0b", "4c0h", "4ohv", "4ohw", "4ohx", "4ohy", "4ohz", "4oi0", "4oi1", "4oi2", "4oi4", "8hmy", "8hmz" ]

14

[ "PUB00042008", "PUB00044697", "PUB00068836", "PUB00068902", "PUB00074964", "PUB00075573", "PUB00075574", "PUB00075575", "PUB00075577", "PUB00075578", "PUB00097408", "PUB00097409", "PUB00100518" ]

[ "17151076", "15109492", "11344258", "18648070", "21993299", "22216186", "24766809", "19299550", "17495927", "17786051", "24813946", "24508575", "23474986" ]

[ "Structure of a nucleotide-bound Clp1-Pcf11 polyadenylation factor.", "Identification of a human endonuclease complex reveals a link between tRNA splicing and pre-mRNA 3' end formation.", "Five subunits are required for reconstitution of the cleavage and polyadenylation activities of Saccharomyces cerevisiae cl...

[ 2007, 2004, 2001, 2008, 2012, 2011, 2014, 2009, 2007, 2007, 2014, 2014, 2013 ]

13

[]

0

null

[ "Eukaryota" ]

[ 4270 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 11, 2, 1, 1, 2, 1, 1, 3, 1, 1, 1, 6 ]

12

true

Domain

Clp1, C-terminal

Clp1_C

5

IPR010656

10,656

TRAP C4-dicarboxylate transport system permease DctM subunit

DctM

Domain

66,632

false

This entry represents the transmembrane segments from a diverse range of transporter proteins from the tripartite ATP-independent periplasmic (TRAP) transport system, in which the driving force for solute accumulation is an electrochemical ion gradient and not ATP hydrolysis [ , , ]. The first TRAP transporter to be ch...

[]

0

[ "PFAM" ]

[ "PF06808" ]

[ "DctM" ]

[ 66632 ]

1

[ "GP" ]

[ "GenProp0176" ]

[ "GP:GenProp0176" ]

1

[ "7qe5", "7qha", "8b01", "8thi", "8thj", "8y4w", "8y4x", "9pym" ]

8

[ "PUB00007692", "PUB00012843", "PUB00015015", "PUB00044822", "PUB00060348", "PUB00060349" ]

[ "9287004", "11803016", "11524131", "16262798", "14668138", "16385129" ]

[ "TRAP transporters: a new family of periplasmic solute transport systems encoded by the dctPQM genes of Rhodobacter capsulatus and by homologs in diverse gram-negative bacteria.", "C4-dicarboxylate carriers and sensors in bacteria.", "The tripartite ATP-independent periplasmic (TRAP) transporters of bacteria an...

[ 1997, 2002, 2001, 2005, 2004, 2006 ]

6

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Sym plasmid", "unclassified sequences" ]

[ 651, 64408, 90, 2, 1481 ]

5

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Domain

TRAP C4-dicarboxylate transport system permease DctM subunit

DctM

8

IPR010657

10,657

ImpA, N-terminal

ImpA_N

Domain

9,564

false

This entry represents a conserved region located towards the N-terminal end of ImpA and related proteins. ImpA is an inner membrane protein, which has been suggested to be involved with proteins that are exported and associated with colony variations in Actinobacillus actinomycetemcomitans [ ]. Note that many members a...

[]

0

[ "PFAM" ]

[ "PF06812" ]

[ "ImpA_N" ]

[ 9564 ]

1

[]

0

[ "6g7b", "6hs5", "6riu", "6rju" ]

4

[ "PUB00012845" ]

[ "11083768" ]

[ "impA, a gene coding for an inner membrane protein, influences colonial morphology of Actinobacillus actinomycetemcomitans." ]

[ 2000 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 9512, 11, 41 ]

3

[]

0

true

Domain

ImpA, N-terminal

ImpA_N

5

IPR010658

10,658

Nodulin-like

Domain

11,860

false

This entry represents a conserved domain within plant nodulin-like proteins and a number of uncharacterised proteins. Including this domain is the Arabidopsis thaliana protein NFD4 (Nuclear Fusion Defective 4) ( ). NFD4 is required for karyogamy during female gametophyte development, when the two polar nuclei fuse to f...

[]

0

[ "PFAM" ]

[ "PF06813" ]

[ "Nodulin-like" ]

[ 11860 ]

1

[]

0

[]

0

[ "PUB00078265" ]

[ "16698901" ]

[ "NUCLEAR FUSION DEFECTIVE1 encodes the Arabidopsis RPL21M protein and is required for karyogamy during female gametophyte development and fertilization." ]

[ 2006 ]

1

[]

0

null

[ "Eukaryota" ]

[ 11860 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 88, 59, 126 ]

3

true

Domain

Nodulin-like

6

IPR010659

10,659

Reverse transcriptase connection

RVT_connect

Domain

58,643

false

This domain is known as the connection domain. This domain lies between the thumb and palm domains [ ].

[ "GO:0003964", "GO:0006278" ]

[ "RNA-directed DNA polymerase activity", "RNA-templated DNA biosynthetic process" ]

[ "molecular_function", "biological_process" ]

2

[ "PFAM" ]

[ "PF06815" ]

[ "RVT_connect" ]

[ 58643 ]

1

[ "EC", "EC", "EC", "EC", "EC", "EC", "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "REACTOME", "REACTOME", "REACTOME",...

[ "2.7.7.-", "2.7.7.49", "2.7.7.7", "3.1.13.2", "3.1.26.13", "3.4.23", "3.4.23.16", "PWY-6322", "PWY-6626", "PWY-6749", "PWY-6955", "PWY-6998", "PWY-7127", "PWY-7419", "PWY-7529", "PWY-7706", "PWY-7719", "PWY-7735", "PWY-7737", "PWY-7769", "PWY-7888", "PWY-7904", "PWY-8117"...

[ "EC:2.7.7.-", "EC:2.7.7.49", "EC:2.7.7.7", "EC:3.1.13.2", "EC:3.1.26.13", "EC:3.4.23", "EC:3.4.23.16", "METACYC:PWY-6322", "METACYC:PWY-6626", "METACYC:PWY-6749", "METACYC:PWY-6955", "METACYC:PWY-6998", "METACYC:PWY-7127", "METACYC:PWY-7419", "METACYC:PWY-7529", "METACYC:PWY-7706", "...

37

[ "1bqm", "1bqn", "1c0t", "1c0u", "1c1b", "1c1c", "1dlo", "1dtq", "1dtt", "1eet", "1ep4", "1fk9", "1fko", "1fkp", "1hmv", "1hni", "1hnv", "1hpz", "1hqe", "1hqu", "1hvu", "1hys", "1ikv", "1ikw", "1ikx", "1iky", "1j5o", "1jkh", "1jla", "1jlb", "1jlc", "1jle"...

453

[ "PUB00012846" ]

[ "1377403" ]

[ "Crystal structure at 3.5 A resolution of HIV-1 reverse transcriptase complexed with an inhibitor." ]

[ 1992 ]

1

[]

0

null

[ "Bacteria", "Lentivirus" ]

[ 6, 58637 ]

2

[]

0

true

Domain

Reverse transcriptase connection

RVT_connect

5

IPR010660

10,660

Notch, NOD domain

Notch_NOD_dom

Domain

4,855

false

NOTCH signalling plays a fundamental role during a great number of developmental processes in multicellular animals [ ]. NOD (NOTCH protein domain) represents a region present in many NOTCH proteins and NOTCH homologues in multiple species such as 0, NOTCH2 and NOTCH3, LIN12, SC1 and TAN1. Role of NOD domain remains to...

[ "GO:0030154", "GO:0016020" ]

[ "cell differentiation", "membrane" ]

[ "biological_process", "cellular_component" ]

2

[ "PFAM", "SMART" ]

[ "PF06816", "SM01338" ]

[ "NOD", "NOD" ]

[ 4835, 4722 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-CEL-1912420", "R-CEL-9013700", "R-CEL-9604323", "R-HSA-1912399", "R-HSA-1912408", "R-HSA-1912420", "R-HSA-210744", "R-HSA-2122947", "R-HSA-2122948", "R-HSA-2197563", "R-HSA-2644606", "R-HSA-2644607", "R-HSA-2660826", "R-HSA-2691232", "R-HSA-2894862", "R-HSA-2979096", "R-HSA-350054...

[ "REACTOME:R-CEL-1912420", "REACTOME:R-CEL-9013700", "REACTOME:R-CEL-9604323", "REACTOME:R-HSA-1912399", "REACTOME:R-HSA-1912408", "REACTOME:R-HSA-1912420", "REACTOME:R-HSA-210744", "REACTOME:R-HSA-2122947", "REACTOME:R-HSA-2122948", "REACTOME:R-HSA-2197563", "REACTOME:R-HSA-2644606", "REACTOME...

48

[ "2oo4", "3eto", "3i08", "3l95", "4zlp", "5czv", "5czx", "6xsw", "7abv" ]

9

[ "PUB00013432" ]

[ "10221902" ]

[ "Notch signaling: cell fate control and signal integration in development." ]

[ 1999 ]

1

[]

0

null

[ "Eumetazoa", "Fibrisoma montanum" ]

[ 4854, 1 ]

2

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 7, 3, 33, 6, 19 ]

6

true

Domain

Notch, NOD domain

Notch_NOD_dom

6

IPR010661

10,661

Reverse transcriptase thumb

RVT_thumb

Domain

173,643

false

This domain is known as the thumb domain. It is composed of a four helix bundle [ ]. Reverse transcriptase converts the viral RNA genome into double-stranded viral DNA. Reverse transcriptase often occurs in a polyprotein; with integrase, ribonuclease H and/or protease, which is cleaved before the enzyme takes action. T...

[ "GO:0003964", "GO:0006278" ]

[ "RNA-directed DNA polymerase activity", "RNA-templated DNA biosynthetic process" ]

[ "molecular_function", "biological_process" ]

2

[ "PFAM" ]

[ "PF06817" ]

[ "RVT_thumb" ]

[ 173643 ]

1

[ "EC", "EC", "EC", "EC", "EC", "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REAC...

[ "2.7.7.-", "2.7.7.49", "2.7.7.7", "3.1.13.2", "3.1.26.13", "3.4.23", "PWY-6322", "PWY-6626", "PWY-6749", "PWY-6955", "PWY-6998", "PWY-7127", "PWY-7419", "PWY-7529", "PWY-7706", "PWY-7719", "PWY-7735", "PWY-7737", "PWY-7769", "PWY-7888", "PWY-7904", "PWY-8117", "PWY-8179",...

[ "EC:2.7.7.-", "EC:2.7.7.49", "EC:2.7.7.7", "EC:3.1.13.2", "EC:3.1.26.13", "EC:3.4.23", "METACYC:PWY-6322", "METACYC:PWY-6626", "METACYC:PWY-6749", "METACYC:PWY-6955", "METACYC:PWY-6998", "METACYC:PWY-7127", "METACYC:PWY-7419", "METACYC:PWY-7529", "METACYC:PWY-7706", "METACYC:PWY-7719",...

36

[ "1bqm", "1bqn", "1c0t", "1c0u", "1c1b", "1c1c", "1dlo", "1dtq", "1dtt", "1eet", "1ep4", "1fk9", "1fko", "1fkp", "1hmv", "1hni", "1hnv", "1hpz", "1hqe", "1hqu", "1hvu", "1hys", "1ikv", "1ikw", "1ikx", "1iky", "1j5o", "1jkh", "1jla", "1jlb", "1jlc", "1jle"...

451

[ "PUB00012846", "PUB00043354" ]

[ "1377403", "18335052" ]

[ "Crystal structure at 3.5 A resolution of HIV-1 reverse transcriptase complexed with an inhibitor.", "Conservation patterns of HIV-1 RT connection and RNase H domains: identification of new mutations in NRTI-treated patients." ]

[ 1992, 2008 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "Retroviridae" ]

[ 10, 2942, 170691 ]

3

[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 15, 10, 1 ]

3

true

Domain

Reverse transcriptase thumb

RVT_thumb

3

IPR010662

10,662

Serine hydrolase RBBP9/YdeN

RBBP9/YdeN

Family

11,180

false

This entry represents RBBP9 proteins. They contain a conserved serine hydrolase motif, GXSXG/A, where the serine is a putative nucleophile [ ]. They contain an α-β hydrolase fold [ , ]. These proteins are implicated in the regulation of TGF-beta signalling, potentially acting as negative regulators by inhibiting the ph...

[ "GO:0016787" ]

[ "hydrolase activity" ]

[ "molecular_function" ]

1

[ "PFAM", "PANTHER" ]

[ "PF06821", "PTHR15394" ]

[ "Ser_hydrolase", "" ]

[ 11014, 3418 ]

2

[]

0

[ "1uxo", "2qs9", "3bdv", "7oex", "9fcr" ]

5

[ "PUB00019449", "PUB00049125", "PUB00070832" ]

[ "15159570", "19004028", "20080647" ]

[ "Harvesting the high-hanging fruit: the structure of the YdeN gene product from Bacillus subtilis at 1.8 angstroms resolution.", "Crystal structure of human retinoblastoma binding protein 9.", "RBBP9: a tumor-associated serine hydrolase activity required for pancreatic neoplasia." ]

[ 2004, 2009, 2010 ]

3

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "metagenomes" ]

[ 9, 10397, 703, 71 ]

4

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 1, 3, 4 ]

4

true

Family

Serine hydrolase RBBP9/YdeN

RBBP9/YdeN

3

IPR010663

10,663

Zinc finger, FPG/IleRS-type

Znf_FPG/IleRS

Domain

41,420

false

This entry represents a zinc finger domain found at the C-terminal in both DNA glycosylase/AP lyase enzymes and in isoleucyl tRNA synthetase. In these two types of enzymes, the C-terminal domain forms a zinc finger. Some related proteins may not bind zinc. DNA glycosylase/AP lyase enzymes are involved in base excision ...

[]

0

[ "PFAM" ]

[ "PF06827" ]

[ "zf-FPG_IleRS" ]

[ 41420 ]

1

[ "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-379726", "R-HSA-9837999", "R-MMU-9837999" ]

[ "REACTOME:R-HSA-379726", "REACTOME:R-HSA-9837999", "REACTOME:R-MMU-9837999" ]

3

[ "1ee8", "1ffy", "1k3w", "1k3x", "1k82", "1kfv", "1l1t", "1l1z", "1l2b", "1l2c", "1l2d", "1nnj", "1pji", "1pjj", "1pm5", "1q39", "1q3b", "1q3c", "1qu2", "1qu3", "1r2y", "1r2z", "1tdz", "1xc8", "2ea0", "2f5n", "2f5o", "2f5p", "2f5q", "2f5s", "2opf", "2oq4"...

87

[ "PUB00002832", "PUB00006454", "PUB00012853", "PUB00014010", "PUB00026619", "PUB00031419", "PUB00038093", "PUB00042928" ]

[ "8473347", "10446055", "11912217", "10921868", "11847126", "15232006", "16697013", "7488160" ]

[ "Fpg protein of Escherichia coli is a zinc finger protein whose cysteine residues have a structural and/or functional role.", "Insights into editing from an ile-tRNA synthetase structure with tRNAile and mupirocin.", "Structure of formamidopyrimidine-DNA glycosylase covalently complexed to DNA.", "Crystal str...

[ 1993, 1999, 2002, 2000, 2002, 2004, 2006, 1995 ]

8

[]

0

null

[ "Archaea", "Bacteria", "Caudoviricetes", "Eukaryota", "unclassified sequences" ]

[ 86, 39742, 3, 1044, 545 ]

5

[ "Arabidopsis thaliana", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 6, 3, 2, 3, 3, 7 ]

6

true

Domain

Zinc finger, FPG/IleRS-type

Znf_FPG/IleRS

1

IPR010664

10,664

Lipopolysaccharide assembly, LptC-related

LipoPS_assembly_LptC-rel

Family

12,558

false

This family consists of several related groups of proteins, one of which is the LptC family. LptC is involved in lipopolysaccharide-assembly on the outer membrane of Gram-negative organisms [ ]. The lipopolysaccharide component of the outer bacterial membrane is transported form its source of origin to the outer membra...

[]

0

[ "PFAM" ]

[ "PF06835" ]

[ "LptC" ]

[ 12558 ]

1

[ "GP" ]

[ "GenProp1079" ]

[ "GP:GenProp1079" ]

1

[ "3my2", "4b54", "6mi7", "6mit", "6mjp", "6s8n" ]

6

[ "PUB00053165" ]

[ "18424520" ]

[ "Functional analysis of the protein machinery required for transport of lipopolysaccharide to the outer membrane of Escherichia coli." ]

[ 2008 ]

1

[]

[ "IPR026265" ]

0

1

0

[ "Bacteria", "Eukaryota", "Siphoviridae sp. ctYaH2", "unclassified sequences" ]

[ 12286, 22, 1, 249 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Lipopolysaccharide assembly, LptC-related

LipoPS_assembly_LptC-rel

5

IPR010665

10,665

Protein of unknown function DUF1240

DUF1240

Family

1,004

false

This family consists of a number of hypothetical putative membrane proteins which are found in gammaproteobacteria, mainly Enterobacterales, Vibrionales and Alteromonadales species. The function of this family is unknown.

[]

0

[ "PFAM" ]

[ "PF06836" ]

[ "DUF1240" ]

[ 1004 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "hydrothermal vent metagenome" ]

[ 1001, 3 ]

2

[]

0

true

Family

Protein of unknown function DUF1240

DUF1240

8

IPR010666

10,666

Zinc finger, GRF-type

Znf_GRF

Domain

27,619

false

This entry represents Glycine-arginine-phenylalanine (GRF)-type zinc fingers (GRF-ZFs), 45- to 50-residue domains with a conserved GRxF motif. GRF-ZFs are widely distributed throughout eukaryotes in proteins that are involved in DNA damage response (DDR), transcriptional regulation, and RNA metabolism. GRF-ZFs are nucl...

[ "GO:0008270" ]

[ "zinc ion binding" ]

[ "molecular_function" ]

1

[ "PFAM", "PROFILE" ]

[ "PF06839", "PS51999" ]

[ "Zn_ribbon_GRF", "ZF_GRF" ]

[ 20958, 26717 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-CEL-5693607", "R-HSA-110328", "R-HSA-110329", "R-HSA-110330", "R-HSA-110331", "R-HSA-5685938", "R-HSA-5685942", "R-HSA-5693554", "R-HSA-5693568", "R-HSA-5693579", "R-HSA-5693607", "R-HSA-5693616", "R-HSA-6804756", "R-HSA-69473", "R-HSA-912446", "R-HSA-9629232", "R-HSA-9636003", ...

[ "REACTOME:R-CEL-5693607", "REACTOME:R-HSA-110328", "REACTOME:R-HSA-110329", "REACTOME:R-HSA-110330", "REACTOME:R-HSA-110331", "REACTOME:R-HSA-5685938", "REACTOME:R-HSA-5685942", "REACTOME:R-HSA-5693554", "REACTOME:R-HSA-5693568", "REACTOME:R-HSA-5693579", "REACTOME:R-HSA-5693607", "REACTOME:R-...

33

[ "5u6z", "6uca", "7jl5", "7omk" ]

4

[ "PUB00014077", "PUB00035804", "PUB00035805", "PUB00035806", "PUB00035807", "PUB00035812", "PUB00103782", "PUB00103783", "PUB00103784", "PUB00103785" ]

[ "12665246", "17210253", "15963892", "15718139", "10529348", "11179890", "28028224", "31695039", "34083046", "32878989" ]

[ "Zinc fingers--folds for many occasions.", "Sticky fingers: zinc-fingers as protein-recognition motifs.", "Multiple modes of RNA recognition by zinc finger proteins.", "Zinc finger proteins: getting a grip on RNA.", "Zinc finger peptides for the regulation of gene expression.", "Zinc finger proteins: new ...

[ 2002, 2007, 2005, 2005, 1999, 2001, 2017, 2019, 2021, 2020 ]

10

[]

0

null

[ "Bacteria", "Eukaryota", "Viruses", "metagenomes" ]

[ 60, 27499, 57, 3 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 79, 1, 8, 1, 16, 16, 5, 99, 23, 1, 1, 42 ]

12

true

Domain

Zinc finger, GRF-type

Znf_GRF

4

IPR010667

10,667

Bacteriophage T4, Gp19, tail tube

Phage_T4_Gp19

Family

8,159

false

This family consists of several tail tube protein gp19 and gp3 from the T4-like viruses [ , ]. The contractile tail of bacteriophage T4 consists of a contractile sheath, a tube and a baseplate. The central cylindrical segment of the tail consists of a rigid tube, composed of multiple copies of gp19, surrounded by the o...

[ "GO:0005198" ]

[ "structural molecule activity" ]

[ "molecular_function" ]

1

[ "PFAM" ]

[ "PF06841" ]

[ "Phage_T4_gp19" ]

[ 8159 ]

1

[]

0

[ "5iv5", "5w5f", "6j0b", "6j0f", "6j0n", "6rao", "6rap", "6rbn", "7adz", "7ae0", "7aeb", "7aef", "7b5h", "7b5i", "8bl4", "9ev2", "9f4a", "9f4b", "9gtp", "9gts", "9qgl", "9qgn" ]

22

[ "PUB00013433", "PUB00013434", "PUB00015589", "PUB00065095", "PUB00077559" ]

[ "3363870", "2403438", "14625682", "23434847", "10633101" ]

[ "The structure of three bacteriophage T4 genes required for tail-tube assembly.", "Structure of the bacteriophage T4 baseplate as determined by chemical cross-linking.", "Structure and morphogenesis of bacteriophage T4.", "The Molecular Architecture of the Bacteriophage T4 Neck.", "Bacteriophage T4 self-ass...

[ 1988, 1990, 2003, 2013, 2000 ]

5

[]

[ "IPR011747" ]

0

1

0

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "metagenomes" ]

[ 164, 7463, 16, 465, 51 ]

5

[]

0

true

Family

Bacteriophage T4, Gp19, tail tube

Phage_T4_Gp19

5

IPR010671

10,671

Disaggregatase-related domain

Disaggr-rel_dom

Domain

290

false

This entry describes a region often found in multiple copies in archaeal disaggregatase proteins [ ]. This region is also found in single copies in several hypothetical proteins from archaea and bacteria.

[]

0

[ "PFAM" ]

[ "PF06848" ]

[ "Disaggr_repeat" ]

[ 290 ]

1

[]

0

[]

0

[ "PUB00105235" ]

[ "18629042" ]

[ "Identification and analysis of novel tandem repeats in the cell surface proteins of archaeal and bacterial genomes using computational tools." ]

[ 2004 ]

1

[]

0

null

[ "Bacteria", "Stenosarchaea group", "ecological metagenomes" ]

[ 57, 224, 9 ]

3

[]

0

true

Domain

Disaggregatase-related domain

Disaggr-rel_dom

7

IPR010672

10,672

IMP biosynthesis enzyme PurP, N-terminal

IMP_biosynth_PurP_N

Domain

992

false

This entry represents the N-terminal domain of PurP. Its function is not known, though it is almost always found in association with . The last two steps of de novo purine biosynthesis are: conversion of 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranosyl 5'-monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide...

[ "GO:0000287", "GO:0005524", "GO:0016879", "GO:0006188" ]

[ "magnesium ion binding", "ATP binding", "ligase activity, forming carbon-nitrogen bonds", "IMP biosynthetic process" ]

[ "molecular_function", "molecular_function", "molecular_function", "biological_process" ]

4

[ "PFAM" ]

[ "PF06849" ]

[ "DUF1246" ]

[ 992 ]

1

[ "EC", "METACYC" ]

[ "6.3.4.23", "PWY-7234" ]

[ "EC:6.3.4.23", "METACYC:PWY-7234" ]

2

[ "2pbz", "2r7k", "2r7l", "2r7m", "2r7n", "2r84", "2r85", "2r86", "2r87" ]

9

[ "PUB00013793", "PUB00025174", "PUB00034499", "PUB00034500" ]

[ "11844782", "11323713", "9150241", "15623504" ]

[ "New class of IMP cyclohydrolases in Methanococcus jannaschii.", "Crystal structure of a bifunctional transformylase and cyclohydrolase enzyme in purine biosynthesis.", "Purine biosynthesis in the domain Archaea without folates or modified folates.", "A Methanocaldococcus jannaschii archaeal signature gene en...

[ 2002, 2001, 1997, 2005 ]

4

[]

0

null

[ "Archaea", "Bacteria", "ecological metagenomes" ]

[ 816, 126, 50 ]

3

[]

0

true

Domain

IMP biosynthesis enzyme PurP, N-terminal

IMP_biosynth_PurP_N

7

IPR010673

10,673

Protein of unknown function UPF0346

UPF0346

Family

2,232

false

This family consists of several short hypothetical bacterial proteins of around 70 residues in length. The majority of the members of this family seem to all belong to the order Bacillales or Lactobacillales. The function of this family is unknown.

[]

0

[ "HAMAP", "NCBIFAM", "PIRSF" ]

[ "MF_01538", "NF010193", "PIRSF037262" ]

[ "UPF0346", "PRK13672.1", "UCP037262" ]

[ 1894, 2232, 1942 ]

3

[]

0

[ "2fj6", "2o6k" ]

2

[]

0

[]

0

null

[ "Bacteria", "Rhizophagus irregularis", "bioreactor metagenome" ]

[ 2230, 1, 1 ]

3

[]

0

true

Family

Protein of unknown function UPF0346

UPF0346

6

IPR010674

10,674

Nucleolar GTP-binding protein 1, Rossman-fold domain

NOG1_Rossman_fold_dom

Domain

6,114

false

This domain represents a conserved region of approximately 60 residues in length within nucleolar GTP-binding protein 1 (NOG1). The NOG1 family includes eukaryotic, bacterial and archaeal proteins. In Saccharomyces cerevisiae, the NOG1 gene has been shown to be essential for cell viability, suggesting that NOG1 may pla...

[ "GO:0005525" ]

[ "GTP binding" ]

[ "molecular_function" ]

1

[ "PFAM" ]

[ "PF06858" ]

[ "NOG1" ]

[ 6114 ]

1

[]

0

[ "2e87", "2qu8", "3jct", "4v7f", "5jcs", "6c0f", "6elz", "6em1", "6em5", "6ft6", "6lss", "6lu8", "6m62", "6n8j", "6n8k", "6n8l", "6ylg", "6ylh", "6ylx", "6yly", "7bt6", "7btb", "7nac", "7nad", "7of1", "7oh3", "7ohp", "7ohq", "7ohr", "7ohs", "7oht", "7ohu"...

114

[ "PUB00014934" ]

[ "12788953" ]

[ "The NOG1 GTP-binding protein is required for biogenesis of the 60 S ribosomal subunit." ]

[ 2003 ]

1

[]

0

null

[ "Archaea", "Eukaryota", "Gluconobacter aidae", "ecological metagenomes" ]

[ 406, 5693, 1, 14 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 18, 1, 1, 4, 6, 3, 1, 5, 6, 1, 1, 15 ]

12

true

Domain

Nucleolar GTP-binding protein 1, Rossman-fold domain

NOG1_Rossman_fold_dom

4

IPR010675

10,675

RNA methyltransferase bin3, C-terminal

Bin3_C

Domain

4,367

false

This entry represents the C-terminal conserved region of the Drosophila probable RNA methyltransferase bin3 [ ]. Proteins containing this domain also include human pre-miRNA 5'-monophosphate methyltransferase BCDIN3D [ ] and 7SK snRNA methylphosphate capping enzyme MEPCE [ ]. This domain contains a conserved HLN motif.

[ "GO:0008168" ]

[ "methyltransferase activity" ]

[ "molecular_function" ]

1

[ "PFAM" ]

[ "PF06859" ]

[ "Bin3" ]

[ 4367 ]

1

[ "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC"...

[ "2.1.1.-", "PWY-1061", "PWY-2083", "PWY-3542", "PWY-4021", "PWY-4161", "PWY-4202", "PWY-5059", "PWY-5105", "PWY-5301", "PWY-5305", "PWY-5479", "PWY-5665", "PWY-5729", "PWY-5748", "PWY-5765", "PWY-5773", "PWY-5846", "PWY-5883", "PWY-5975", "PWY-5987", "PWY-601", "PWY-6045"...

[ "EC:2.1.1.-", "METACYC:PWY-1061", "METACYC:PWY-2083", "METACYC:PWY-3542", "METACYC:PWY-4021", "METACYC:PWY-4161", "METACYC:PWY-4202", "METACYC:PWY-5059", "METACYC:PWY-5105", "METACYC:PWY-5301", "METACYC:PWY-5305", "METACYC:PWY-5479", "METACYC:PWY-5665", "METACYC:PWY-5729", "METACYC:PWY-5...

147

[ "5una", "6dcb", "6dcc", "6l8u", "7slp", "7slq" ]

6

[ "PUB00077147", "PUB00077148", "PUB00077149" ]

[ "1071748", "23063121", "17643375" ]

[ "Caries and the planning of dental treatment for five-year-old children.", "Human RNA methyltransferase BCDIN3D regulates microRNA processing.", "Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme." ]

[ 1976, 2012, 2007 ]

3

[]

0

null

[ "Eukaryota", "bird metagenome" ]

[ 4366, 1 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)", "Zea mays" ]

[ 4, 1, 8, 7, 4, 4, 2, 6, 1, 6 ]

10

true

Domain

RNA methyltransferase bin3, C-terminal

Bin3_C

1

IPR010677

10,677

Human herpes virus type 4, BALF1

HHV-4_BALF1

Family

68

false

Epstein-Barr virus (strain GD1) (HHV-4), a human tumour DNA virus and a prominent member of gamma-herpesviruses, encodes homologues of cellular antiapoptotic viral Bcl-2 proteins BALF1 and BHRF1. They protect the virus from apoptosis in its host cell during virus synthesis [ , ]. The virus infects B lymphocytes to esta...

[]

0

[ "PFAM" ]

[ "PF06861" ]

[ "BALF1" ]

[ 68 ]

1

[]

0

[]

0

[ "PUB00012884", "PUB00043588", "PUB00043589" ]

[ "11836425", "16277553", "16087121" ]

[ "Epstein-Barr virus BALF1 is a BCL-2-like antagonist of the herpesvirus antiapoptotic BCL-2 proteins.", "Epstein-Barr virus provides a new paradigm: a requirement for the immediate inhibition of apoptosis.", "Epstein-Barr virus encoded BALF1 gene is transcribed in Burkitt's lymphoma cell lines and in nasopharyn...

[ 2002, 2005, 2005 ]

3

[]

0

null

[ "Gammaherpesvirinae", "Hymenolepis diminuta" ]

[ 66, 2 ]

2

[]

0

true

Family

Human herpes virus type 4, BALF1

HHV-4_BALF1

2

IPR010678

10,678

U3 small nucleolar RNA-associated protein 25

UTP25

Family

5,109

false

This family represents U3 small nucleolar RNA-associated protein 25 (UTP25), a DEAD-box RNA helicase-like protein component of the ribosomal small subunit processome for the biogenesis of ribosomes, which functions in pre-ribosomal RNA (pre-rRNA) processing. U3 small nucleolar RNA-associated protein 25 homologue (also ...

[ "GO:0034511", "GO:0006364", "GO:0005730" ]

[ "U3 snoRNA binding", "rRNA processing", "nucleolus" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PANTHER" ]

[ "PTHR12933" ]

[ "" ]

[ 5109 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-6790901", "R-HSA-6791226", "R-MMU-6791226", "R-RNO-6791226", "R-SCE-6791226", "R-SPO-6791226" ]

[ "REACTOME:R-HSA-6790901", "REACTOME:R-HSA-6791226", "REACTOME:R-MMU-6791226", "REACTOME:R-RNO-6791226", "REACTOME:R-SCE-6791226", "REACTOME:R-SPO-6791226" ]

6

[]

0

[ "PUB00097919", "PUB00097921", "PUB00097922", "PUB00100328" ]

[ "25007945", "27657329", "23357851", "20877469" ]

[ "MiR-195 affects cell migration and cell proliferation by down-regulating DIEXF in Hirschsprung's disease.", "Phosphorylation of Def Regulates Nucleolar p53 Turnover and Cell Cycle Progression through Def Recruitment of Calpain3.", "Def defines a conserved nucleolar pathway that leads p53 to proteasome-independ...

[ 2014, 2016, 2013, 2010 ]

4

[]

0

null

[ "Eukaryota" ]

[ 5109 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 5, 1, 1, 3, 4, 3, 1, 5, 3, 1, 1, 8 ]

12

true

Family

U3 small nucleolar RNA-associated protein 25

UTP25

7

IPR010679

10,679

Domain of unknown function DUF1254

DUF1254

Domain

9,640

false

This entry represents an immunoglobulin-like β-sandwich domain found in a group of hypothetical proteins of unknown function.

[]

0

[ "PFAM" ]

[ "PF06863" ]

[ "DUF1254" ]

[ 9640 ]

1

[]

0

[ "2p3y", "3u07", "3vb9" ]

3

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Imitervirales", "metagenomes" ]

[ 88, 8957, 516, 3, 76 ]

5

[]

0

true

Domain

Domain of unknown function DUF1254

DUF1254

7

IPR010682

10,682

Plant self-incompatibility response

SCRL

Family

968

false

This family consists of several plant self-incompatibility response (SCRL) proteins [ ]. The male component of the self-incompatibility response in Brassica has been shown to be encoded by the S locus cysteine-rich gene (SCR). SCR is related, at the sequence level, to the pollen coat protein (PCP) gene family whose mem...

[ "GO:0007165" ]

[ "signal transduction" ]

[ "biological_process" ]

1

[ "PFAM", "PANTHER" ]

[ "PF06876", "PTHR34450" ]

[ "SCRL", "" ]

[ 828, 769 ]

2

[]

0

[ "1ugl", "5gyy", "6kyw" ]

3

[ "PUB00012891", "PUB00101452" ]

[ "11437247", "16782760" ]

[ "Two large Arabidopsis thaliana gene families are homologous to the Brassica gene superfamily that encodes pollen coat proteins and the male component of the self-incompatibility response.", "The transition to self-compatibility in Arabidopsis thaliana and evolution within S-haplotypes over 10 Myr." ]

[ 2001, 2006 ]

2

[]

0

null

[ "Pentapetalae" ]

[ 968 ]

1

[ "Arabidopsis thaliana" ]

[ 76 ]

1

true

Family

Plant self-incompatibility response

SCRL

4

IPR010683

10,683

Protein of unknown function DUF1262

DUF1262

Family

1,761

false

This family represents a conserved region within a number of proteins of unknown function that seem to be specific to Arabidopsis thaliana. Note that some family members contain more than one copy of this region.

[]

0

[ "PFAM" ]

[ "PF06880" ]

[ "DUF1262" ]

[ 1761 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Spermatophyta" ]

[ 1761 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 51, 15, 2 ]

3

true

Family

Protein of unknown function DUF1262

DUF1262

6

IPR010686

10,686

Oil body-associated protein-like

OBAP-like

Family

4,333

false

This entry includes a group of oil body associated proteins (OBAPs) from plants and some uncharacterised proteins from fungi and bacteria. The plant obap proteins are predominantly expressed during embryo development and may be involved in the stability of oil bodies [ ].

[]

0

[ "PFAM", "PANTHER" ]

[ "PF06884", "PTHR31360" ]

[ "DUF1264", "" ]

[ 4315, 4230 ]

2

[]

0

[]

0

[ "PUB00079176" ]

[ "24406791" ]

[ "The evolutionary conserved oil body associated protein OBAP1 participates in the regulation of oil body size." ]

[ 2014 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "ecological metagenomes" ]

[ 8, 1513, 2806, 6 ]

4

[ "Arabidopsis thaliana", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 13, 1, 9, 13 ]

4

true

Family

Oil body-associated protein-like

OBAP-like

9

IPR010690

10,690

Putative stage IV sporulation YqfD

YqfD

Family

2,880

false

This family consists of several putative bacterial stage IV sporulation (SpoIV) proteins. YqfD of Bacillus subtilis ( ) is known to be essential for efficient sporulation although its exact function is unknown [ ].

[]

0

[ "PFAM", "PIRSF", "NCBIFAM" ]

[ "PF06898", "PIRSF029895", "TIGR02876" ]

[ "YqfD", "SpoIV", "spore_yqfD" ]

[ 2880, 1997, 1919 ]

3

[ "GP" ]

[ "GenProp0610" ]

[ "GP:GenProp0610" ]

1

[]

0

[ "PUB00012907" ]

[ "12662922" ]

[ "The sigmaE regulon and the identification of additional sporulation genes in Bacillus subtilis." ]

[ 2003 ]

1

[]

0

null

[ "Bacteria", "Phytophthora kernoviae 00238/432", "Siphoviridae sp. ctjdk2", "metagenomes" ]

[ 2855, 1, 1, 23 ]

4

[]

0

true

Family

Putative stage IV sporulation YqfD

YqfD

6

IPR010692

10,692

RTX iron-regulated FrpC

FrpC

Family

55

false

This family consists of several RTX iron-regulated FrpC proteins which appear to be found exclusively in Neisseria meningitidis. FrpC has been shown to be related to the RTX family of bacterial cytotoxins. FrpC is found in the meningococcal outer membrane. The function of this family is unknown although it is thought t...

[]

0

[ "PFAM" ]

[ "PF06901" ]

[ "FrpC" ]

[ 55 ]

1

[]

0

[ "5edf", "5edj" ]

2

[ "PUB00012909" ]

[ "12654851" ]

[ "Neisseria meningitidis RTX proteins are not required for virulence in infant rats." ]

[ 2003 ]

1

[]

0

null

[ "Bacteria" ]

[ 55 ]

1

[]

0

true

Family

RTX iron-regulated FrpC

FrpC

1

IPR010693

10,693

Divergent 4Fe-4S mono-cluster

Divergent_4Fe-4S_mono-cluster

Domain

3,467

false

Members of this family contain three highly conserved cysteine residues. This family includes proteins containing divergent domains which are most likely to bind to iron-sulfur clusters.

[]

0

[ "PFAM" ]

[ "PF06902" ]

[ "Fer4_19" ]

[ 3467 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eumetazoa", "ecological metagenomes" ]

[ 148, 3272, 2, 45 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Domain

Divergent 4Fe-4S mono-cluster

Divergent_4Fe-4S_mono-cluster

4

IPR010694

10,694

Uncharacterised protein family VirK

Uncharacterised_VirK

Family

656

false

This family consists of several bacterial VirK proteins of around 145 residues in length. The function of this family is unknown [ ].

[]

0

[ "PFAM" ]

[ "PF06903" ]

[ "VirK" ]

[ 656 ]

1

[]

0

[ "5xta" ]

1

[ "PUB00012910" ]

[ "11434457" ]

[ "Sequence characterization of the vir region of a nopaline type Ti plasmid, pTi-SAKURA." ]

[ 2001 ]

1

[]

0

null

[ "Bacteria", "Bilateria", "hydrocarbon metagenome" ]

[ 617, 38, 1 ]

3

[]

0

true

Family

Uncharacterised protein family VirK

Uncharacterised_VirK

4

IPR010695

10,695

Fas apoptotic inhibitory molecule 1

FAIM1

Family

2,133

false

FAIM1 (Fas apoptotic inhibitory molecule 1) plays a role as an inducible effector molecule that mediates Fas resistance produced by surface Ig engagement in B cells [ ].

[ "GO:0043066" ]

[ "negative regulation of apoptotic process" ]

[ "biological_process" ]

1

[ "PFAM", "PANTHER" ]

[ "PF06905", "PTHR13088" ]

[ "FAIM1", "" ]

[ 2114, 1833 ]

2

[]

0

[ "2kd2", "2kw1", "3mx7" ]

3

[ "PUB00077146" ]

[ "10075978" ]

[ "A novel gene coding for a Fas apoptosis inhibitory molecule (FAIM) isolated from inducibly Fas-resistant B lymphocytes." ]

[ 1999 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "marine sediment metagenome" ]

[ 42, 2090, 1 ]

3

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 6, 1, 2, 5, 5 ]

6

true

Family

Fas apoptotic inhibitory molecule 1

FAIM1

3

IPR010696

10,696

Protein of unknown function DUF1272

DUF1272

Family

3,061

false

This family consists of several hypothetical bacterial proteins of around 80 residues in length. This family contains a number of conserved cysteine residues and its function is unknown.

[]

0

[ "PFAM" ]

[ "PF06906" ]

[ "DUF1272" ]

[ 3061 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Opisthokonta", "unclassified sequences" ]

[ 4, 3023, 14, 20 ]

4

[]

0

true

Family

Protein of unknown function DUF1272

DUF1272

6

IPR010697

10,697

YspA SLOG family

YspA

Family

4,753

false

Family in the SLOG superfamily showing fusions to NAD utilization and ADP-ribosylation domains including NUDIX, NADAR and MACRO. Members of this family are predicted to function as sensors of nucleotide, nucleotide-derived ligands, or nucleic acids, which are potentially processed/modified by the associating enzymes [ ...

[]

0

[ "HAMAP", "PFAM", "PIRSF", "PANTHER" ]

[ "MF_01575", "PF06908", "PIRSF021290", "PTHR38440" ]

[ "UPF0398", "YpsA", "DUF1273", "" ]

[ 2092, 4130, 2960, 4713 ]

4

[]

0

[ "2nx2" ]

1

[ "PUB00091021" ]

[ "26590262" ]

[ "Comparative genomic analyses reveal a vast, novel network of nucleotide-centric systems in biological conflicts, immunity and signaling." ]

[ 2015 ]

1

[]

0

null

[ "Bacteria", "Phytophthora kernoviae 00238/432", "Stenosarchaea group", "Viruses", "metagenomes" ]

[ 4650, 1, 3, 56, 43 ]

5

[]

0

true

Family

YspA SLOG family

YspA

7

IPR010699

10,699

Protein of unknown function DUF1275

DUF1275

Family

18,264

false

This family consists of several hypothetical bacterial proteins of around 200 residues in length. The function of this family is unknown although a few members are thought to be membrane proteins.

[]

0

[ "PFAM" ]

[ "PF06912" ]

[ "DUF1275" ]

[ 18264 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Siphoviridae sp. ct2u94", "metagenomes" ]

[ 37, 14139, 4029, 1, 58 ]

5

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)" ]

[ 2 ]

1

true

Family

Protein of unknown function DUF1275

DUF1275

3

IPR010702

10,702

Periplasmic pectate lyase

Pectate_lyase_2

Family

398

false

This family consists of several Enterobacterial periplasmic pectate lyase proteins. A major virulence determinant of the plant-pathogenic enterobacterium Erwinia chrysanthemi is the production of pectate lyase enzymes that degrade plant cell walls [ ].

[ "GO:0016837", "GO:0045490", "GO:0042597" ]

[ "carbon-oxygen lyase activity, acting on polysaccharides", "pectin catabolic process", "periplasmic space" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PFAM", "PIRSF" ]

[ "PF06917", "PIRSF001432" ]

[ "Pectate_lyase_2", "Pect_lyase" ]

[ 398, 168 ]

2

[]

0

[ "2v8i", "2v8j", "2v8k", "5a29", "6ojk", "6ojl" ]

6

[ "PUB00012916" ]

[ "12423024" ]

[ "Coupling of iron assimilation and pectinolysis in Erwinia chrysanthemi 3937." ]

[ 2002 ]

1

[]

0

null

[ "Bacteria", "Halobacteriales", "ecological metagenomes" ]

[ 383, 10, 5 ]

3

[]

0

true

Family

Periplasmic pectate lyase

Pectate_lyase_2

6

IPR010707

10,707

Protein of unknown function DUF1285

DUF1285

Family

4,266

false

This family consists of several hypothetical bacterial proteins. The structure of some members has been solved but the function of this family is still unknown [ ].

[]

0

[ "PIRSF" ]

[ "PIRSF029557" ]

[ "UCP029557" ]

[ 4266 ]

1

[]

0

[ "2ra9", "2re3" ]

2

[ "PUB00062529" ]

[ "20944214" ]

[ "Structures of the first representatives of Pfam family PF06938 (DUF1285) reveal a new fold with repeated structural motifs and possible involvement in signal transduction." ]

[ 2010 ]

1

[]

0

null

[ "Pseudomonadati", "Symbiodinium necroappetens", "metagenomes" ]

[ 4230, 1, 35 ]

3

[]

0

true

Family

Protein of unknown function DUF1285

DUF1285

1

IPR010708

10,708

5'(3')-deoxyribonucleotidase

Family

6,934

false

This family consists of several 5' nucleotidase, deoxy (Pyrimidine), and cytosolic type C (NT5C) proteins. 5'(3')-deoxyribonucleotidase is a ubiquitous enzyme in mammalian cells whose physiological function is not known [ ].

[ "GO:0008253", "GO:0009264" ]

[ "5'-nucleotidase activity", "deoxyribonucleotide catabolic process" ]

[ "molecular_function", "biological_process" ]

2

[ "PFAM" ]

[ "PF06941" ]

[ "NT5C" ]

[ 6934 ]

1

[ "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC"...

[ "3.1.3.-", "PWY-4702", "PWY-5491", "PWY-6148", "PWY-6352", "PWY-6365", "PWY-6366", "PWY-6368", "PWY-6456", "PWY-6575", "PWY-6627", "PWY-6664", "PWY-6686", "PWY-6720", "PWY-6724", "PWY-6955", "PWY-6990", "PWY-6991", "PWY-7018", "PWY-7119", "PWY-7321", "PWY-7531", "PWY-7771...

[ "EC:3.1.3.-", "METACYC:PWY-4702", "METACYC:PWY-5491", "METACYC:PWY-6148", "METACYC:PWY-6352", "METACYC:PWY-6365", "METACYC:PWY-6366", "METACYC:PWY-6368", "METACYC:PWY-6456", "METACYC:PWY-6575", "METACYC:PWY-6627", "METACYC:PWY-6664", "METACYC:PWY-6686", "METACYC:PWY-6720", "METACYC:PWY-6...

40

[ "1mh9", "1q91", "1q92", "1z4i", "1z4j", "1z4k", "1z4l", "1z4m", "1z4p", "1z4q", "2i7d", "2jao", "2jar", "2jau", "2jaw", "3bwv", "3u13", "3u19", "4e88", "4l57", "4l6a", "4l6c", "4mum", "4mwo", "4nfl", "4yih", "4yik", "6g22", "6g2l", "6g2m", "6g2n" ]

31

[ "PUB00012938" ]

[ "10681516" ]

[ "Mammalian 5'(3')-deoxyribonucleotidase, cDNA cloning, and overexpression of the enzyme in Escherichia coli and mammalian cells." ]

[ 2000 ]

1

[]

[ "IPR009206" ]

0

1

0

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "metagenomes" ]

[ 77, 3714, 2682, 316, 145 ]

5

[ "Arabidopsis thaliana", "Danio rerio", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 4, 1, 8, 3, 3, 5, 7 ]

7

true

Family

5'(3')-deoxyribonucleotidase

6

IPR010710

10,710

Protein of unknown function DUF1289

DUF1289

Family

12,639

false

This family consists of a number of hypothetical bacterial proteins. The aligned region spans around 56 residues and contains 4 highly conserved cysteine residues towards the N terminus. The function of this family is unknown.

[]

0

[ "PFAM", "PANTHER" ]

[ "PF06945", "PTHR35175" ]

[ "DUF1289", "" ]

[ 12633, 10771 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Caudoviricetes", "Eukaryota", "unclassified sequences" ]

[ 14, 12485, 9, 30, 101 ]

5

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Protein of unknown function DUF1289

DUF1289

8

IPR010712

10,712

Arsenical-resistance operon trans-acting repressor ArsD

Arsenical-R_ArsD

Family

2,724

false

This family consists of several bacterial arsenical resistance operon trans-acting repressor ArsD proteins. ArsD is a trans-acting repressor of the arsRDABC operon that confers resistance to arsenicals and antimonials in Escherichia coli. It possesses two-pairs of vicinal cysteine residues, Cys(12)-Cys(13) and Cys(112)...

[ "GO:0003677", "GO:0045892", "GO:0046685" ]

[ "DNA binding", "negative regulation of DNA-templated transcription", "response to arsenic-containing substance" ]

[ "molecular_function", "biological_process", "biological_process" ]

3

[ "PFAM" ]

[ "PF06953" ]

[ "ArsD" ]

[ 2724 ]

1

[]

0

[ "3kgk", "3ktb", "3mwh" ]

3

[ "PUB00013437" ]

[ "11980902" ]

[ "Evidence for cooperativity between the four binding sites of dimeric ArsD, an As(III)-responsive transcriptional regulator." ]

[ 2002 ]

1

[]

0

null

[ "Bacteria", "Stenosarchaea group", "unclassified sequences" ]

[ 2575, 96, 53 ]

3

[]

0

true

Family

Arsenical-resistance operon trans-acting repressor ArsD

Arsenical-R_ArsD

8

IPR010713

10,713

Xyloglucan endo-transglycosylase, C-terminal

XET_C

Domain

16,055

false

This entry represents the C terminus (approximately 60 residues) of plant xyloglucan endo-transglycosylases (XET). Xyloglucan is the predominant hemicellulose in the cell walls of most dicotyledons. With cellulose, it forms a network that strengthens the cell wall. XET catalyses the splitting of xyloglucan chains and t...

[ "GO:0016762", "GO:0044042", "GO:0005618", "GO:0048046" ]

[ "xyloglucan:xyloglucosyl transferase activity", "glucan metabolic process", "cell wall", "apoplast" ]

[ "molecular_function", "biological_process", "cellular_component", "cellular_component" ]

4

[ "PFAM" ]

[ "PF06955" ]

[ "XET_C" ]

[ 16055 ]

1

[ "EC" ]

[ "2.4.1.207" ]

[ "EC:2.4.1.207" ]

1

[ "1umz", "1un1", "2uwa", "2uwb", "2uwc", "2vh9" ]

6

[ "PUB00012943", "PUB00100393", "PUB00100394" ]

[ "9487728", "27242828", "27966647" ]

[ "Biochemical and molecular characterisation of xyloglucan endotransglycosylase from ripe kiwifruit.", "Isolation and Characterization of Two Persimmon Xyloglucan Endotransglycosylase/Hydrolase (XTH) Genes That Have Divergent Functions in Cell Wall Modification and Fruit Postharvest Softening.", "DkXTH8, a novel...

[ 1998, 2016, 2016 ]

3

[]

0

null

[ "Eukaryota" ]

[ 16055 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 131, 74, 116 ]

3

true

Domain

Xyloglucan endo-transglycosylase, C-terminal

XET_C

7

IPR010714

10,714

Coatomer, alpha subunit, C-terminal

Coatomer_asu_C

Domain

6,529

false

Proteins synthesised on the ribosome and processed in the endoplasmic reticulum are transported from the Golgi apparatus to the trans-Golgi network (TGN), and from there via small carrier vesicles to their final destination compartment. This traffic is bidirectional, to ensure that proteins required to form vesicles ar...

[ "GO:0005198", "GO:0005515", "GO:0006886", "GO:0016192", "GO:0030126" ]

[ "structural molecule activity", "protein binding", "intracellular protein transport", "vesicle-mediated transport", "COPI vesicle coat" ]

[ "molecular_function", "molecular_function", "biological_process", "biological_process", "cellular_component" ]

5

[ "PFAM" ]

[ "PF06957" ]

[ "COPI_C" ]

[ 6529 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-DDI-6807878", "R-DDI-6811434", "R-HSA-6807878", "R-HSA-6811434", "R-MMU-6807878", "R-MMU-6811434", "R-SCE-6807878", "R-SCE-6811434", "R-SPO-6807878", "R-SPO-6811434" ]

[ "REACTOME:R-DDI-6807878", "REACTOME:R-DDI-6811434", "REACTOME:R-HSA-6807878", "REACTOME:R-HSA-6811434", "REACTOME:R-MMU-6807878", "REACTOME:R-MMU-6811434", "REACTOME:R-SCE-6807878", "REACTOME:R-SCE-6811434", "REACTOME:R-SPO-6807878", "REACTOME:R-SPO-6811434" ]

10

[ "3mkr", "3mv2", "3mv3", "5a1u", "5a1v", "5a1w", "5a1x", "5a1y", "5nzr", "5nzs", "5nzt", "5nzu", "5nzv", "6tzt", "6u3v", "6u3w", "9qpq" ]

17

[ "PUB00012946", "PUB00030524", "PUB00033346", "PUB00035767", "PUB00035768", "PUB00035769", "PUB00100149", "PUB00103198" ]

[ "9261053", "14690497", "12893528", "11208122", "17041781", "15261670", "26160949", "28621666" ]

[ "Coatomer (COPI)-coated vesicles: role in intracellular transport and protein sorting.", "Gamma-COP appendage domain - structure and function.", "ER-to-Golgi transport: COP I and COP II function (Review).", "Traffic COPs of the early secretory pathway.", "COPI-mediated transport.", "COP and clathrin-coate...

[ 1997, 2004, 2003, 2000, 2006, 2004, 2015, 2017 ]

8

[]

0

null

[ "Eukaryota" ]

[ 6529 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 10, 1, 2, 2, 5, 7, 1, 8, 7, 1, 1, 17 ]

12

true

Domain

Coatomer, alpha subunit, C-terminal

Coatomer_asu_C

9

IPR010716

10,716

RecQ helicase-like 5

RECQ5

Domain

956

false

This entry represents a domain found in RECQ5. RecQ helicases is a group of highly conserved 3'-5' DNA helicases involved in maintaining genomic stability. RECQ5 plays an important role in DNA replication, transcription and repair [ , ]. It interacts with RNA polymerase II to reduce transcription-associated replication...

[]

0

[ "PFAM" ]

[ "PF06959" ]

[ "RecQ5" ]

[ 956 ]

1

[ "EC" ]

[ "5.6.2.4" ]

[ "EC:5.6.2.4" ]

1

[ "8qq2", "8qw8", "8qw9", "9ei1", "9ei2", "9ei3", "9ei4", "9hvo", "9hvq", "9hwg" ]

10

[ "PUB00077134", "PUB00077135", "PUB00077136", "PUB00077137", "PUB00077138", "PUB00077139" ]

[ "20643585", "20348101", "20231364", "23748380", "23715498", "22013166" ]

[ "Human RECQL5 overcomes thymidine-induced replication stress.", "Physical interaction of RECQ5 helicase with RAD51 facilitates its anti-recombinase activity.", "RecQL5 promotes genome stabilization through two parallel mechanisms--interacting with RNA polymerase II and acting as a helicase.", "Structural mimi...

[ 2010, 2010, 2010, 2013, 2013, 2012 ]

6

[]

0

null

[ "Gnathostomata" ]

[ 956 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 5, 9, 2, 4 ]

4

true

Domain

RecQ helicase-like 5

RECQ5

6

IPR010718

10,718

Protein of unknown function DUF1294

DUF1294

Family

8,919

false

This family includes a number of hypothetical bacterial and archaeal proteins of unknown function.

[]

0

[ "PFAM" ]

[ "PF06961" ]

[ "DUF1294" ]

[ 8919 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "metagenomes" ]

[ 113, 8548, 207, 51 ]

4

[]

0

true

Family

Protein of unknown function DUF1294

DUF1294

4

IPR010719

10,719

Methyltransferase MnmM-like

MnmM_MeTrfase

Family

5,165

false

This entry represents the family of tRNA (mnm(5)s(2)U34)-methyltransferase MnmM (also known as YtqB in Bacillus subtilis) and related proteins. This enzyme is involved in the biosynthesis of 5-methylaminomethyl-2-thiouridine (mnm5s2U) at the wobble position (U34) in tRNA by catalysing the transfer of a methyl group fro...

[]

0

[ "PFAM", "PANTHER" ]

[ "PF06962", "PTHR35276" ]

[ "rRNA_methylase", "" ]

[ 5099, 5120 ]

2

[ "EC", "METACYC" ]

[ "2.1.1.61", "PWY-7892" ]

[ "EC:2.1.1.61", "METACYC:PWY-7892" ]

2

[ "3eey", "3lby", "3mti", "4pon", "4poo", "8h0s", "8h0t", "8h1a", "8h1b", "8h26", "8h27" ]

11

[ "PUB00151124", "PUB00151126" ]

[ "36762482", "24637210" ]

[ "Identification of a novel 5-aminomethyl-2-thiouridine methyltransferase in tRNA modification.", "Structural analysis of a putative SAM-dependent methyltransferase, YtqB, from Bacillus subtilis." ]

[ 2023, 2014 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 4313, 837, 15 ]

3

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 5, 1, 10 ]

3

true

Family

Methyltransferase MnmM-like

MnmM_MeTrfase

8

IPR010720

10,720

Alpha-L-arabinofuranosidase, C-terminal

Alpha-L-AF_C

Domain

17,211

false

This entry represents the C terminus (approximately 200 residues) of bacterial and eukaryotic alpha-L-arabinofuranosidase ( ). This catalyses the hydrolysis of non-reducing terminal alpha-L-arabinofuranosidic linkages in L-arabinose-containing polysaccharides [ ].

[ "GO:0046556", "GO:0046373" ]

[ "alpha-L-arabinofuranosidase activity", "L-arabinose metabolic process" ]

[ "molecular_function", "biological_process" ]

2

[ "PFAM", "SMART" ]

[ "PF06964", "SM00813" ]

[ "Alpha-L-AF_C", "Alpha-L-AF_C" ]

[ 16989, 17013 ]

2

[ "EC" ]

[ "3.2.1.55" ]

[ "EC:3.2.1.55" ]

1

[ "1pz2", "1pz3", "1qw8", "1qw9", "2c7f", "2c8n", "2vrk", "2vrq", "2y2w", "3s2c", "3ug3", "3ug4", "3ug5", "4atw", "5o7z", "5o80", "5o81", "5o82", "6d25", "6sxu", "6sxv", "6zps", "6zpv", "6zpw", "6zpx", "6zpy", "6zpz", "6zq0", "6zq1", "6zt6", "6zt7", "6zt8"...

35

[ "PUB00012951" ]

[ "7887599" ]

[ "Purification and characterization of alpha-L-arabinofuranosidase from Bacillus stearothermophilus T-6." ]

[ 1995 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "metagenomes", "virus sp. ctHJb31" ]

[ 118, 12024, 4949, 119, 1 ]

5

[ "Arabidopsis thaliana", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 10, 1, 25, 60 ]

4

true

Domain

Alpha-L-arabinofuranosidase, C-terminal

Alpha-L-AF_C

1

IPR010721

10,721

Probable O-methyltransferase UstE-like

UstE-like

Family

13,943

false

This family contains a number of bacterial and eukaryotic proteins that are mostly uncharacterised. This entry includes UstE, a probable O-methyltransferase part of the gene cluster that mediates the biosynthesis of ustilaginoidins [ ].

[]

0

[ "PFAM", "PANTHER" ]

[ "PF06966", "PTHR32251" ]

[ "DUF1295", "" ]

[ 13929, 12869 ]

2

[]

0

[]

0

[ "PUB00101454" ]

[ "31050129" ]

[ "Enantioselective Phenol Coupling by Laccases in the Biosynthesis of Fungal Dimeric Naphthopyrones." ]

[ 2019 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "metagenomes" ]

[ 18, 4972, 8779, 174 ]

4

[ "Arabidopsis thaliana", "Danio rerio", "Drosophila melanogaster", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)", "Zea mays" ]

[ 24, 1, 2, 4, 6, 1, 12 ]

7

true

Family

Probable O-methyltransferase UstE-like

UstE-like

3

IPR010722

10,722

Biotin and thiamin synthesis-associated domain

BATS_dom

Domain

28,902

false

This domain is found in biotin synthase and 2-iminoacetate synthase. The latter enzyme is involved in thiamine diphosphate biosynthesis. The reactions catalysed by these enzymes involve the binding of co-factors and both enzymes function as dimers [ , ]. This domain may therefore be involved in co-factor binding or dim...

[]

0

[ "PFAM", "SMART" ]

[ "PF06968", "SM00876" ]

[ "BATS", "BATS" ]

[ 27348, 28792 ]

2

[ "EC" ]

[ "2.8.1.6" ]

[ "EC:2.8.1.6" ]

1

[ "1r30", "3ciw", "3cix", "3iix", "3iiz", "4jxc", "4jy8", "4jy9", "4jyd", "4jye", "4jyf", "4rtb", "4wcx", "5fep", "5fes", "5few", "5fex", "5fez", "5ff0", "5ff2", "5ff3", "5ff4", "7o1o", "7o1p", "7o1s", "7o1t", "7o25", "7o26", "7pd1", "7pd2", "8qmk", "8qml"...

36

[ "PUB00012954", "PUB00012955" ]

[ "12482614", "12650933" ]

[ "The PLP-dependent biotin synthase from Escherichia coli: mechanistic studies.", "Thiamine biosynthesis in Escherichia coli: isolation and initial characterisation of the ThiGH complex." ]

[ 2002, 2003 ]

2

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 434, 25666, 2516, 286 ]

4

[ "Arabidopsis thaliana", "Escherichia coli (strain K12)", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)", "Zea mays" ]

[ 4, 2, 1, 2, 1, 1, 13 ]

7

true

Domain

Biotin and thiamin synthesis-associated domain

BATS_dom

8

IPR010723

10,723

HemN, C-terminal

HemN_C

Domain

29,760

false

This domain is found in the C-terminal region of oxygen-independent coproporphyrinogen-III oxidases (HemN) [ ]. This enzyme catalyses the oxygen-independent conversion of coproporphyrinogen-III to protoporphyrinogen-IX [ ], one of the last steps in haem biosynthesis. The function of this domain is unclear, but comparis...

[]

0

[ "PFAM" ]

[ "PF06969" ]

[ "HemN_C" ]

[ 29760 ]

1

[]

0

[ "1olt" ]

1

[ "PUB00012956", "PUB00022360" ]

[ "12196143", "14633981" ]

[ "Terminal steps of haem biosynthesis.", "Crystal structure of coproporphyrinogen III oxidase reveals cofactor geometry of Radical SAM enzymes." ]

[ 2002, 2003 ]

2

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 13, 28284, 1092, 371 ]

4

[ "Danio rerio", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus" ]

[ 1, 2, 1, 1, 4, 4 ]

6

true

Domain

HemN, C-terminal

HemN_C

9

IPR010724

10,724

Replication initiator A, N-terminal

RepA_N

Domain

4,299

false

This entry represents the N terminus (approximately 80 residues) of replication initiator protein A (RepA), a DNA replication initiator in plasmids [ ]. Most proteins in this entry are bacterial, but viral members are also included.

[]

0

[ "PFAM" ]

[ "PF06970" ]

[ "RepA_N" ]

[ 4299 ]

1

[]

0

[ "4pql", "4pt7", "4pta", "5kbj" ]

4

[ "PUB00012957" ]

[ "12637554" ]

[ "Structural changes in RepA, a plasmid replication initiator, upon binding to origin DNA." ]

[ 2003 ]

1

[]

0

null

[ "Bacteria", "Hirondellea gigas", "Viruses", "unclassified sequences" ]

[ 4207, 1, 60, 31 ]

4

[]

0

true

Domain

Replication initiator A, N-terminal

RepA_N

4

IPR010725

10,725

Domain of unknown function DUF1299

DUF1299

Domain

16

false

This entry represents a conserved region approximately 50 residues long within a number of proteins of unknown function that seem to be specific to Arabidopsis thaliana. Note that many proteins contain multiple copies of this region.

[]

0

[ "PFAM" ]

[ "PF06975" ]

[ "DUF1299" ]

[ 16 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Eukaryota" ]

[ 16 ]

1

[ "Arabidopsis thaliana" ]

[ 11 ]

1

true

Domain

Domain of unknown function DUF1299

DUF1299

1

IPR010727

10,727

Protein of unknown function DUF1302

DUF1302

Family

6,159

false

This family contains a number of hypothetical bacterial proteins of unknown function that are approximately 600 residues long. Most family members seem to be from Proteobacteria.

[]

0

[ "PFAM" ]

[ "PF06980" ]

[ "DUF1302" ]

[ 6159 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 6063, 9, 87 ]

3

[]

0

true

Family

Protein of unknown function DUF1302

DUF1302

3