LiteFold/InterPro · Datasets at Hugging Face

IPR010458

10,458

Trichodiene synthase, ascomycetes

TRI5_ascomyc

Family

150

false

This family consists of several fungal trichodiene synthase proteins. TRI5 encodes the enzyme trichodiene synthase, which has been shown to catalyse the first step in the trichothecene pathways of Fusarium and Trichothecium species [ , ].

[ "GO:0045482", "GO:0016106" ]

[ "trichodiene synthase activity", "sesquiterpenoid biosynthetic process" ]

[ "molecular_function", "biological_process" ]

2

[ "PIRSF" ]

[ "PIRSF001388" ]

[ "TRI5" ]

[ 150 ]

1

[ "EC", "METACYC" ]

[ "4.2.3.6", "PWY-7711" ]

[ "EC:4.2.3.6", "METACYC:PWY-7711" ]

2

[ "1jfa", "1jfg", "1kiy", "1kiz", "1yj4", "1yyq", "1yyr", "1yys", "1yyt", "1yyu", "2aek", "2ael", "2aet", "2ps4", "2ps5", "2ps6", "2ps7", "2ps8", "2q9y", "2q9z" ]

20

[ "PUB00013416", "PUB00013417" ]

[ "9529523", "11698643" ]

[ "Characterization of the gene cluster for biosynthesis of macrocyclic trichothecenes in Myrothecium roridum.", "Structure of trichodiene synthase from Fusarium sporotrichioides provides mechanistic inferences on the terpene cyclization cascade." ]

[ 1998, 2001 ]

2

[ "IPR024652" ]

[]

1

0

1

[ "Dikarya" ]

[ 150 ]

1

[]

0

true

Family

Trichodiene synthase, ascomycetes

TRI5_ascomyc

7

IPR010462

10,462

Ectoine synthase

Ectoine_synth

Family

4,790

false

This family consists of several bacterial ectoine synthase proteins. The ectABC genes encode the diaminobutyric acid acetyltransferase (EctA), the diaminobutyric acid aminotransferase (EctB), and the ectoine synthase (EctC). Together these proteins constitute the ectoine biosynthetic pathway [ , ]. Ectoine synthase, al...

[ "GO:0033990", "GO:0019491" ]

[ "ectoine synthase activity", "ectoine biosynthetic process" ]

[ "molecular_function", "biological_process" ]

2

[ "HAMAP", "NCBIFAM", "PFAM", "PANTHER", "CDD" ]

[ "MF_01255", "NF009806", "PF06339", "PTHR39289", "cd06978" ]

[ "Ectoine_synth", "PRK13290.1", "Ectoine_synth", "", "cupin_EctC" ]

[ 4166, 4580, 4789, 4761, 4626 ]

5

[ "EC", "GP" ]

[ "4.2.1.108", "GenProp0268" ]

[ "EC:4.2.1.108", "GP:GenProp0268" ]

2

[ "5bxx", "5by5", "5onm", "5onn", "5ono" ]

5

[ "PUB00012330", "PUB00060957", "PUB00096313" ]

[ "11823218", "9864317", "30674920" ]

[ "Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.", "Characterization of biosynthetic enzymes for ectoine as a compatible solute in a moderately halophilic eubacterium, Halomonas elongata.", "Illuminating the catalytic core of ectoine synthase thro...

[ 2002, 1999, 2019 ]

3

[]

0

null

[ "Archaea", "Bacteria", "Caudoviricetes", "Eukaryota", "unclassified sequences" ]

[ 21, 4625, 2, 116, 26 ]

5

[]

0

true

Family

Ectoine synthase

Ectoine_synth

9

IPR010463

10,463

Protein of unknown function DUF1057

DUF1057

Family

684

false

This entry consists of proteins of unknown function which have an alpha/beta hydrolase fold.

[]

0

[ "PFAM" ]

[ "PF06342" ]

[ "DUF1057" ]

[ 684 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "marine metagenome" ]

[ 12, 671, 1 ]

3

[ "Caenorhabditis elegans" ]

[ 8 ]

1

true

Family

Protein of unknown function DUF1057

DUF1057

6

IPR010466

10,466

Protein of unknown function DUF1058

DUF1058

Family

4,501

false

SH3 (src Homology-3) domains are small protein modules containing approximately 50 amino acid residues [ , ]. They are found in a great variety of intracellular or membrane-associated proteins [ , , ] for example, in a variety of proteins with enzymatic activity, in adaptor proteins, such as fodrin and yeast actin bind...

[]

0

[ "PFAM" ]

[ "PF06347" ]

[ "SH3_4" ]

[ 4501 ]

1

[]

0

[]

0

[ "PUB00001025", "PUB00001031", "PUB00001644", "PUB00004203", "PUB00005506", "PUB00007145" ]

[ "15335710", "7953536", "1639195", "7531822", "14731533", "11256992" ]

[ "SH2 and SH3 domains.", "SH3 domains. Molecular 'Velcro'.", "SH3--an abundant protein domain in search of a function.", "Protein modules and signalling networks.", "Signalling through SH2 and SH3 domains.", "SH3 domains: complexity in moderation." ]

[ 1993, 1994, 1992, 1995, 1993, 2001 ]

6

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 4408, 25, 68 ]

3

[]

0

true

Family

Protein of unknown function DUF1058

DUF1058

5

IPR010468

10,468

Hormone-sensitive lipase, N-terminal

HSL_N

Domain

2,443

false

This domain is found in several mammalian hormone-sensitive lipase (HSL) proteins. Hormone-sensitive lipase, a key enzyme in fatty acid mobilisation, overall energy homeostasis, and possibly steroidogenesis, is acutely controlled via reversible phosphorylation by catecholamines and insulin [ ].

[ "GO:0016298", "GO:0008203", "GO:0016042" ]

[ "lipase activity", "cholesterol metabolic process", "lipid catabolic process" ]

[ "molecular_function", "biological_process", "biological_process" ]

3

[ "PFAM" ]

[ "PF06350" ]

[ "HSL_N" ]

[ 2443 ]

1

[ "EC", "EC", "METACYC", "REACTOME", "REACTOME" ]

[ "3.1.1.23", "3.1.1.79", "PWY-7420", "R-HSA-163560", "R-HSA-9841922" ]

[ "EC:3.1.1.23", "EC:3.1.1.79", "METACYC:PWY-7420", "REACTOME:R-HSA-163560", "REACTOME:R-HSA-9841922" ]

5

[ "8zvq" ]

1

[ "PUB00012333" ]

[ "3420405" ]

[ "Hormone-sensitive lipase: sequence, expression, and chromosomal localization to 19 cent-q13.3." ]

[ 1988 ]

1

[]

0

null

[ "Eukaryota", "bird metagenome" ]

[ 2441, 2 ]

2

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 19, 1, 8, 5, 6 ]

6

true

Domain

Hormone-sensitive lipase, N-terminal

HSL_N

7

IPR010470

10,470

Beet necrotic yellow vein virus, movement protein TGB3

BNYVV_TGB3

Family

37

false

This entry is represented by Beet necrotic yellow vein virus, movement protein TGB3 (also known as p15) which participates in the transport of viral RNA to the plasmodesmata [ ].

[]

0

[ "PFAM" ]

[ "PF06358" ]

[ "BNYVV_TGB3" ]

[ 37 ]

1

[]

0

[]

0

[ "PUB00097496" ]

[ "10796018" ]

[ "P42 movement protein of Beet necrotic yellow vein virus is targeted by the movement proteins P13 and P15 to punctate bodies associated with plasmodesmata." ]

[ 2000 ]

1

[]

0

null

[ "Benyvirus" ]

[ 37 ]

1

[]

0

true

Family

Beet necrotic yellow vein virus, movement protein TGB3

BNYVV_TGB3

9

IPR010471

10,471

Protein of unknown function DUF1068

DUF1068

Family

2,366

false

This family consists of several hypothetical plant proteins from Arabidopsis thaliana and Oryza sativa. The function of this family is unknown.

[]

0

[ "PFAM" ]

[ "PF06364" ]

[ "DUF1068" ]

[ 2366 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Eukaryota" ]

[ 2366 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 28, 4, 9 ]

3

true

Family

Protein of unknown function DUF1068

DUF1068

9

IPR010472

10,472

Formin, FH3 domain

FH3_dom

Domain

21,428

false

Formin homology (FH) proteins play a crucial role in the reorganisation of the actin cytoskeleton, which mediates various functions of the cell cortex including motility, adhesion, and cytokinesis [ ]. Formins are multidomain proteins that interact with diverse signalling molecules and cytoskeletal proteins, although s...

[ "GO:0003779", "GO:0016043" ]

[ "actin binding", "cellular component organization" ]

[ "molecular_function", "biological_process" ]

2

[ "PFAM", "SMART" ]

[ "PF06367", "SM01139" ]

[ "Drf_FH3", "Drf_FH3" ]

[ 21160, 20791 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-5663220", "R-BTA-9013106", "R-DME-5663220", "R-DME-6785631", "R-DME-6798695", "R-DME-8980692", "R-DME-9013026", "R-DME-9013149", "R-DME-9013404", "R-DME-9013405", "R-DME-9013406", "R-DME-9013408", "R-DME-9013423", "R-DME-9035034", "R-DRE-8980692", "R-HSA-4086400", "R-HSA-56632...

[ "REACTOME:R-BTA-5663220", "REACTOME:R-BTA-9013106", "REACTOME:R-DME-5663220", "REACTOME:R-DME-6785631", "REACTOME:R-DME-6798695", "REACTOME:R-DME-8980692", "REACTOME:R-DME-9013026", "REACTOME:R-DME-9013149", "REACTOME:R-DME-9013404", "REACTOME:R-DME-9013405", "REACTOME:R-DME-9013406", "REACTOM...

57

[ "1z2c", "2bap", "2bnx", "2f31", "3eg5", "3o4x", "3obv", "4dvg", "4uwx", "4yc7", "4ydh", "8fg1", "9azp" ]

13

[ "PUB00014909", "PUB00014910", "PUB00014914", "PUB00014915" ]

[ "10631086", "12538772", "9606213", "11171383" ]

[ "Formin family proteins in cytoskeletal control.", "ForC, a novel type of formin family protein lacking an FH1 domain, is involved in multicellular development in Dictyostelium discoideum.", "FH3, a domain found in formins, targets the fission yeast formin Fus1 to the projection tip during conjugation.", "Loc...

[ 2000, 2003, 1998, 2001 ]

4

[]

0

null

[ "Eukaryota" ]

[ 21428 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strai...

[ 7, 95, 17, 48, 32, 1, 50, 1, 2 ]

9

true

Domain

Formin, FH3 domain

FH3_dom

2

IPR010473

10,473

Formin, GTPase-binding domain

GTPase-bd

Domain

22,270

false

Diaphanous-related formins (Drfs) are a family of formin homology (FH) proteins that act as effectors of Rho small GTPases during growth factor-induced cytoskeletal remodelling, stress fibre formation, and cell division [ ]. Drf proteins are characterised by a variety of shared domains: an N-terminal GTPase-binding dom...

[ "GO:0003779", "GO:0031267", "GO:0030036" ]

[ "actin binding", "small GTPase binding", "actin cytoskeleton organization" ]

[ "molecular_function", "molecular_function", "biological_process" ]

3

[ "PFAM", "SMART" ]

[ "PF06371", "SM01140" ]

[ "Drf_GBD", "Drf_GBD" ]

[ 21450, 21578 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-5663220", "R-BTA-9013106", "R-DDI-193648", "R-DDI-9013148", "R-DDI-9013149", "R-DME-5663220", "R-DME-6785631", "R-DME-6798695", "R-DME-8980692", "R-DME-9013026", "R-DME-9013149", "R-DME-9013404", "R-DME-9013405", "R-DME-9013406", "R-DME-9013408", "R-DME-9013423", "R-DME-903503...

[ "REACTOME:R-BTA-5663220", "REACTOME:R-BTA-9013106", "REACTOME:R-DDI-193648", "REACTOME:R-DDI-9013148", "REACTOME:R-DDI-9013149", "REACTOME:R-DME-5663220", "REACTOME:R-DME-6785631", "REACTOME:R-DME-6798695", "REACTOME:R-DME-8980692", "REACTOME:R-DME-9013026", "REACTOME:R-DME-9013149", "REACTOME...

60

[ "1z2c", "2bap", "2bnx", "2f31", "3eg5", "3o4x", "3obv", "4dvg", "4uwx", "4yc7", "4ydh", "8fg1", "9azp" ]

13

[ "PUB00012332", "PUB00014909" ]

[ "12676083", "10631086" ]

[ "Disruption of the Diaphanous-related formin Drf1 gene encoding mDia1 reveals a role for Drf3 as an effector for Cdc42.", "Formin family proteins in cytoskeletal control." ]

[ 2003, 2000 ]

2

[]

0

null

[ "Eukaryota" ]

[ 22270 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strai...

[ 5, 96, 15, 57, 30, 2, 48, 2, 4 ]

9

true

Domain

Formin, GTPase-binding domain

GTPase-bd

7

IPR010474

10,474

AP-3 complex subunit delta domain, metazoa

AP3D_dom_metazoa

Domain

2,517

false

AP-3 complex subunit delta-1 (AP3D1) is part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. AP3D1 is required for efficient transport of VSV-G (vesicular stomatitis virus glycoprotein) from the tran...

[ "GO:0015031", "GO:0030123" ]

[ "protein transport", "AP-3 adaptor complex" ]

[ "biological_process", "cellular_component" ]

2

[ "PFAM", "SMART" ]

[ "PF06375", "SM01354" ]

[ "AP3D1", "BLVR" ]

[ 2389, 2474 ]

2

[]

0

[ "4afi" ]

1

[ "PUB00078818" ]

[ "11997454" ]

[ "The delta subunit of AP-3 is required for efficient transport of VSV-G from the trans-Golgi network to the cell surface." ]

[ 2002 ]

1

[]

0

null

[ "Eukaryota" ]

[ 2517 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 16, 5, 3, 5, 5 ]

6

true

Domain

AP-3 complex subunit delta domain, metazoa

AP3D_dom_metazoa

8

IPR010479

10,479

BH3-interacting domain death agonist

BID

Family

953

false

Bcl-2 proteins are central regulators of caspase activation, and play a key role in cell death by regulating the integrity of the mitochondrial and endoplasmic reticulum (ER) membranes [ ]. At least 20 Bcl-2 proteins have been reported in mammals, and several others have been identified in viruses. Bcl-2 family protein...

[ "GO:0043065", "GO:0005737" ]

[ "positive regulation of apoptotic process", "cytoplasm" ]

[ "biological_process", "cellular_component" ]

2

[ "PFAM", "PIRSF", "PANTHER" ]

[ "PF06393", "PIRSF038018", "PTHR35447" ]

[ "BID", "BID", "" ]

[ 944, 415, 921 ]

3

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-111447", "R-HSA-111452", "R-HSA-111453", "R-HSA-114294", "R-HSA-6803204", "R-HSA-75108", "R-MMU-111447", "R-MMU-111452", "R-MMU-111453", "R-MMU-114294", "R-MMU-75108", "R-RNO-111452", "R-RNO-111453", "R-RNO-114294", "R-RNO-75108", "R-SSC-111447", "R-SSC-111452", "R-SSC-11145...

[ "REACTOME:R-HSA-111447", "REACTOME:R-HSA-111452", "REACTOME:R-HSA-111453", "REACTOME:R-HSA-114294", "REACTOME:R-HSA-6803204", "REACTOME:R-HSA-75108", "REACTOME:R-MMU-111447", "REACTOME:R-MMU-111452", "REACTOME:R-MMU-111453", "REACTOME:R-MMU-114294", "REACTOME:R-MMU-75108", "REACTOME:R-RNO-1114...

20

[ "1ddb", "1zy3", "2bid", "2kbw", "2m5b", "2m5i", "2voi", "4bd2", "4qve", "4zeq", "4zig", "4zii", "5ajj", "5c3f", "5ua4", "7m5a", "7m5b", "7p33", "7qtw" ]

19

[ "PUB00012361", "PUB00017291", "PUB00017301" ]

[ "10089878", "9735050", "12631689" ]

[ "Solution structure of the proapoptotic molecule BID: a structural basis for apoptotic agonists and antagonists.", "The Bcl-2 protein family: arbiters of cell survival.", "Cellular distribution of Bcl-2 family proteins." ]

[ 1999, 1998, 2003 ]

3

[]

0

null

[ "Gnathostomata" ]

[ 953 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 6, 2, 3 ]

4

true

Family

BH3-interacting domain death agonist

BID

8

IPR010480

10,480

Pepsin inhibitor-3-like repeated domain

Pepsin-I3

Domain

473

false

Pepsin inhibitor-3 consists of two domains, each comprising an antiparallel β-sheet flanked by an α-helix. In the enzyme-inhibitor complex, the N-terminal β-strand of PI-3 pairs with one strand of the active site flap region of pepsin [ ]. The two domains are tandem repeats of sequence, and has therefore been termed re...

[]

0

[ "PFAM" ]

[ "PF06394" ]

[ "Pepsin-I3" ]

[ 473 ]

1

[]

0

[ "1f32", "1f34" ]

2

[ "PUB00012362" ]

[ "10932249" ]

[ "Structural basis for the inhibition of porcine pepsin by Ascaris pepsin inhibitor-3." ]

[ 2000 ]

1

[]

0

null

[ "Chromadorea" ]

[ 473 ]

1

[ "Caenorhabditis elegans" ]

[ 2 ]

1

true

Domain

Pepsin inhibitor-3-like repeated domain

Pepsin-I3

6

IPR010481

10,481

Cdc24/Scd1, N-terminal

Cdc24/Scd1_N

Domain

1,998

false

This domain can be found in budding yeast Cdc24 and fission yeast Scd1. They are guanine nucleotide exchange factor (GEF) for Cdc42 [ , ].

[]

0

[ "PFAM" ]

[ "PF06395" ]

[ "CDC24" ]

[ 1998 ]

1

[]

0

[]

0

[ "PUB00044754", "PUB00078883" ]

[ "17460121", "12972551" ]

[ "Sequential and distinct roles of the cadherin domain-containing protein Axl2p in cell polarization in yeast cell cycle.", "Gef1p and Scd1p, the Two GDP-GTP exchange factors for Cdc42p, form a ring structure that shrinks during cytokinesis in Schizosaccharomyces pombe." ]

[ 2007, 2003 ]

2

[]

0

null

[ "Eukaryota", "Silvanigrella aquatica" ]

[ 1997, 1 ]

2

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 1, 1 ]

3

true

Domain

Cdc24/Scd1, N-terminal

Cdc24/Scd1_N

1

IPR010482

10,482

TECPR1-like, DysF domain

TECPR1-like_DysF

Domain

7,112

false

This entry represents the DysF domain found twice in human Tectonin β-propeller repeat-containing protein 1 (TECPR1) and similar animal sequences. TECPR1 is a tethering factor involved in autophagy, autophagosome maturation and selective autophagy against bacterial pathogens [ , ]. This protein has two 5-bladed β-prope...

[]

0

[ "PFAM" ]

[ "PF06398" ]

[ "Pex24p" ]

[ 7112 ]

1

[]

0

[ "4cah", "4cai", "8p5p" ]

3

[ "PUB00012364", "PUB00044889", "PUB00075565", "PUB00094379", "PUB00155243", "PUB00155245" ]

[ "12707309", "16303567", "21575909", "22342342", "21669930", "37409490" ]

[ "YHR150w and YDR479c encode peroxisomal integral membrane proteins involved in the regulation of peroxisome number, size, and distribution in Saccharomyces cerevisiae.", "A large-scale screen in S. pombe identifies seven novel genes required for critical meiotic events.", "A Tecpr1-dependent selective autophagy...

[ 2003, 2005, 2011, 2012, 2011, 2023 ]

6

[]

0

null

[ "Eukaryota" ]

[ 7112 ]

1

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 7, 1, 1, 1, 3, 2, 5, 2 ]

8

true

Domain

TECPR1-like, DysF domain

TECPR1-like_DysF

8

IPR010483

10,483

Alpha-2-macroglobulin RAP, C-terminal

Alpha_2_MRAP_C

Domain

1,688

false

The alpha-2-macroglobulin receptor-associated protein (RAP) is a intracellular glycoprotein that binds to the 2-macroglobulin receptor and other members of the low density lipoprotein receptor family. The protein inhibits binding of all currently known ligands of these receptors [ ]. Two different studies have provided...

[ "GO:0008201", "GO:0050750", "GO:0005783" ]

[ "heparin binding", "low-density lipoprotein particle receptor binding", "endoplasmic reticulum" ]

[ "molecular_function", "molecular_function", "cellular_component" ]

3

[ "PFAM" ]

[ "PF06401" ]

[ "Alpha-2-MRAP_C" ]

[ 1688 ]

1

[]

0

[ "2fcw", "2ftu", "2p01", "2p03", "8jut", "8jxf", "8jxg", "8jxh", "8jxi" ]

9

[ "PUB00012366" ]

[ "9207124" ]

[ "The solution structure of the N-terminal domain of alpha2-macroglobulin receptor-associated protein." ]

[ 1997 ]

1

[]

0

null

[ "Eukaryota" ]

[ 1688 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 2, 1, 4, 12, 4 ]

6

true

Domain

Alpha-2-macroglobulin RAP, C-terminal

Alpha_2_MRAP_C

1

IPR010486

10,486

HNS-dependent expression A/B

HNS-dep_expression_A/B

Family

1,586

false

HNS (histone-like nucleoid structuring)-dependent expression A (HdeA) protein is a stress response protein found in highly acid resistant bacteria such as Shigella flexneri and Escherichia coli, but which is lacking in mildly acid tolerant bacteria such as Salmonella [ ]. HdeA is one of the most abundant proteins found...

[]

0

[ "PFAM" ]

[ "PF06411" ]

[ "HdeA" ]

[ 1586 ]

1

[]

0

[ "1bg8", "1dj8", "2myj", "2xuv", "4xvv", "5wyo" ]

6

[ "PUB00013251", "PUB00013252" ]

[ "10623550", "12694615" ]

[ "HDEA, a periplasmic protein that supports acid resistance in pathogenic enteric bacteria.", "Regulatory network of acid resistance genes in Escherichia coli." ]

[ 2000, 2003 ]

2

[]

[ "IPR024972", "IPR028623" ]

0

2

0

[ "Bacteria", "Protostomia", "ecological metagenomes" ]

[ 1574, 2, 10 ]

3

[ "Escherichia coli (strain K12)" ]

[ 2 ]

1

true

Family

HNS-dependent expression A/B

HNS-dep_expression_A/B

3

IPR010487

10,487

Neugrin/Rrg9

NGRN/Rrg9

Family

2,627

false

This entry include neugrin from mammals and Rrg9 from fungi. Neugrin is mainly expressed in neurons and may play an important role in the process of neuronal differentiation [ ]. Rrg9 is required for respiratory activity and maintenance and expression of the mitochondrial genome [ ].

[]

0

[ "PFAM", "PANTHER" ]

[ "PF06413", "PTHR13475" ]

[ "Neugrin", "" ]

[ 2477, 2518 ]

2

[ "REACTOME", "REACTOME" ]

[ "R-HSA-6793080", "R-HSA-9937008" ]

[ "REACTOME:R-HSA-6793080", "REACTOME:R-HSA-9937008" ]

2

[]

0

[ "PUB00012376", "PUB00071556" ]

[ "11118320", "19751518" ]

[ "Two novel genes, human neugrin and mouse m-neugrin, are upregulated with neuronal differentiation in neuroblastoma cells.", "Genome-wide deletion mutant analysis reveals genes required for respiratory growth, mitochondrial genome maintenance and mitochondrial protein synthesis in Saccharomyces cerevisiae." ]

[ 2000, 2009 ]

2

[]

0

null

[ "Eukaryota" ]

[ 2627 ]

1

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 2, 4, 1, 1, 3, 1, 1 ]

8

true

Family

Neugrin/Rrg9

NGRN/Rrg9

6

IPR010488

10,488

Zeta toxin domain

Zeta_toxin_domain

Domain

7,777

false

This entry represents a domain originally identified in bacterial zeta toxin proteins, where it comprises the whole protein [ ]. It has subsequently been found in a number of other proteins, such as polynucleotide kinase and 2',3'-cyclic-nucleotide 3'-phosphodiesterase. It appears to function as a kinase domain [ , ].

[ "GO:0005524", "GO:0016301" ]

[ "ATP binding", "kinase activity" ]

[ "molecular_function", "molecular_function" ]

2

[ "PFAM" ]

[ "PF06414" ]

[ "Zeta_toxin" ]

[ 7777 ]

1

[ "EC" ]

[ "2.7.1.176" ]

[ "EC:2.7.1.176" ]

1

[ "1gvn", "2p5t", "3q8x", "4z8q", "4z8t", "4z8u", "4z8v" ]

7

[ "PUB00012377", "PUB00028903", "PUB00056183" ]

[ "12571357", "12220496", "21445328" ]

[ "Crystal structure of the plasmid maintenance system epsilon/zeta: functional mechanism of toxin zeta and inactivation by epsilon 2 zeta 2 complex formation.", "Structure of a tRNA repair enzyme and molecular biology workhorse: T4 polynucleotide kinase.", "A novel mechanism of programmed cell death in bacteria ...

[ 2003, 2002, 2011 ]

3

[]

0

null

[ "Bacteria", "Eukaryota", "Methanobacteriati", "Viruses", "metagenomes", "plasmids" ]

[ 5166, 2485, 11, 35, 78, 2 ]

6

[ "Arabidopsis thaliana", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)", "Zea mays" ]

[ 22, 1, 7, 1, 13 ]

5

true

Domain

Zeta toxin domain

Zeta_toxin_domain

6

IPR010489

10,489

Effector protein NleG

Effector_NleG

Family

656

false

Many bacterial pathogens deliver effector proteins into host cells via a type III secretion system, enabling them to manipulate host cell biology in ways that benefit the pathogen. In enterohaemorrhagic Escherichia coli O157:H7, the NleG protein and its homologues represent the largest family of effector proteins, with...

[ "GO:0004842", "GO:0044403" ]

[ "ubiquitin-protein transferase activity", "biological process involved in symbiotic interaction" ]

[ "molecular_function", "biological_process" ]

2

[ "PFAM" ]

[ "PF06416" ]

[ "T3SS_NleG" ]

[ 656 ]

1

[ "EC", "METACYC" ]

[ "2.3.2.27", "PWY-7511" ]

[ "EC:2.3.2.27", "METACYC:PWY-7511" ]

2

[ "2kkx", "2kky", "5vgc" ]

3

[ "PUB00056590", "PUB00056591", "PUB00160788" ]

[ "16990433", "20585566", "36511702" ]

[ "An extensive repertoire of type III secretion effectors in Escherichia coli O157 and the role of lambdoid phages in their dissemination.", "NleG Type 3 effectors from enterohaemorrhagic Escherichia coli are U-Box E3 ubiquitin ligases.", "Distinct Molecular Features of NleG Type 3 Secreted Effectors Allow for D...

[ 2006, 2010, 2023 ]

3

[]

0

null

[ "Caudoviricetes", "Enterobacteriaceae", "viral metagenome" ]

[ 9, 646, 1 ]

3

[]

0

true

Family

Effector protein NleG

Effector_NleG

6

IPR010490

10,490

Conserved oligomeric Golgi complex subunit 6

COG6

Family

5,178

false

COG6 is a component of the peripheral membrane COG (conserved oligomeric Golgi) complex that is involved in intra-Golgi protein trafficking. COG is located at the cis-Golgi, regulates tethering of retrograde intra-Golgi vesicles and is required for normal Golgi morphology and localisation [ , , ]. COG subunits belong t...

[ "GO:0006891", "GO:0017119" ]

[ "intra-Golgi vesicle-mediated transport", "Golgi transport complex" ]

[ "biological_process", "cellular_component" ]

2

[ "PANTHER", "SMART" ]

[ "PTHR21506", "SM01087" ]

[ "", "COG6" ]

[ 5145, 4657 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-CEL-6807878", "R-CEL-6811438", "R-DDI-6807878", "R-DDI-6811438", "R-DME-6807878", "R-DME-6811438", "R-DME-6811440", "R-HSA-6807878", "R-HSA-6811438", "R-HSA-6811440", "R-MMU-6807878", "R-MMU-6811438", "R-MMU-6811440", "R-RNO-6807878", "R-RNO-6811438", "R-RNO-6811440" ]

[ "REACTOME:R-CEL-6807878", "REACTOME:R-CEL-6811438", "REACTOME:R-DDI-6807878", "REACTOME:R-DDI-6811438", "REACTOME:R-DME-6807878", "REACTOME:R-DME-6811438", "REACTOME:R-DME-6811440", "REACTOME:R-HSA-6807878", "REACTOME:R-HSA-6811438", "REACTOME:R-HSA-6811440", "REACTOME:R-MMU-6807878", "REACTOM...

16

[]

0

[ "PUB00017118", "PUB00062958", "PUB00100047", "PUB00100048" ]

[ "12006647", "12011112", "34061181", "29335562" ]

[ "Identification of Sec36p, Sec37p, and Sec38p: components of yeast complex that contains Sec34p and Sec35p.", "The Sec34/Sec35p complex, a Ypt1p effector required for retrograde intra-Golgi trafficking, interacts with Golgi SNAREs and COPI vesicle coat proteins.", "Homology and Modular Evolution of CATCHR at th...

[ 2002, 2002, 2021, 2018 ]

4

[]

0

null

[ "Enterococcus", "Eukaryota" ]

[ 4, 5174 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 3, 1, 1, 1, 4, 5, 1, 5, 9, 1, 1, 10 ]

12

true

Family

Conserved oligomeric Golgi complex subunit 6

COG6

6

IPR010491

10,491

PRP1 splicing factor, N-terminal

PRP1_N

Domain

4,802

false

This domain is specific to the N-terminal part of the prp1 splicing factor, which is involved in mRNA splicing (and possibly also poly(A)+ RNA nuclear export and cell cycle progression). This domain is specific to the N terminus of the RNA splicing factor encoded by prp1 [ ]. It is involved in mRNA splicing and possibl...

[ "GO:0000398" ]

[ "mRNA splicing, via spliceosome" ]

[ "biological_process" ]

1

[ "PFAM" ]

[ "PF06424" ]

[ "PRP1_N" ]

[ 4802 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-72163", "R-BTA-72165", "R-HSA-72163", "R-HSA-72165", "R-MMU-72163", "R-MMU-72165", "R-RNO-72163", "R-RNO-72165" ]

[ "REACTOME:R-BTA-72163", "REACTOME:R-BTA-72165", "REACTOME:R-HSA-72163", "REACTOME:R-HSA-72165", "REACTOME:R-MMU-72163", "REACTOME:R-MMU-72165", "REACTOME:R-RNO-72163", "REACTOME:R-RNO-72165" ]

8

[ "3jcm", "3jcr", "5gan", "5gap", "5nrl", "5o9z", "5zwm", "5zwo", "6ah0", "6ahd", "6qw6", "6qx9", "8h6e", "8h6j", "8h6k", "8h6l", "8q7n", "8q7q", "8q7v", "8q7w", "8q7x", "8q91", "8qo9", "8qoz", "8qp8", "8qp9", "8qpa", "8qpb", "8qpe", "8qpk", "8qxd", "8qzs"...

39

[ "PUB00012380" ]

[ "9003295" ]

[ "Isolation of novel pre-mRNA splicing mutants of Schizosaccharomyces pombe." ]

[ 1996 ]

1

[]

0

null

[ "Eukaryota", "Lettuce mosaic virus" ]

[ 4780, 22 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 9, 1, 1, 1, 1, 2, 1, 6, 4, 1, 1, 4 ]

12

true

Domain

PRP1 splicing factor, N-terminal

PRP1_N

7

IPR010493

10,493

Serine acetyltransferase, N-terminal

Ser_AcTrfase_N

Domain

10,190

false

The N-terminal domain of serine acetyltransferase has a sequence that is conserved in plants [ ] and bacteria [ ].

[ "GO:0009001", "GO:0006535", "GO:0005737" ]

[ "serine O-acetyltransferase activity", "L-cysteine biosynthetic process from L-serine", "cytoplasm" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PFAM", "SMART" ]

[ "PF06426", "SM00971" ]

[ "SATase_N", "SATase_N" ]

[ 10185, 8111 ]

2

[ "EC", "METACYC", "METACYC", "METACYC", "METACYC" ]

[ "2.3.1.30", "PWY-6936", "PWY-7274", "PWY-7870", "PWY-8071" ]

[ "EC:2.3.1.30", "METACYC:PWY-6936", "METACYC:PWY-7274", "METACYC:PWY-7870", "METACYC:PWY-8071" ]

5

[ "1s80", "1ssm", "1ssq", "1sst", "1t3d", "3gvd", "3mc4", "4h7o", "4hzc", "4hzd", "4n69", "4n6a", "4n6b", "6jvu", "6wye", "7e3y", "7ra4", "8i04", "8i06", "8i09" ]

20

[ "PUB00012382" ]

[ "7608200" ]

[ "Molecular cloning and characterization of a plant serine acetyltransferase playing a regulatory role in cysteine biosynthesis from watermelon." ]

[ 1995 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "Methanobacteriota", "metagenomes" ]

[ 7210, 2788, 127, 65 ]

4

[ "Arabidopsis thaliana", "Escherichia coli (strain K12)", "Oryza sativa subsp. japonica", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)", "Zea mays" ]

[ 17, 1, 10, 1, 19 ]

5

true

Domain

Serine acetyltransferase, N-terminal

Ser_AcTrfase_N

5

IPR010494

10,494

Repeat of unknown function DUF1079

DUF1079

Repeat

82

false

This entry represents several repeats of 31 residues in length and seems to be exclusive to Moraxella catarrhalis UspA proteins. The UspA1 and UspA2 proteins of M. catarrhalis are structurally related and are exposed on the bacterial cell surface where can function adhesins [ ]. This repeat is commonly found with the .

[]

0

[ "PFAM" ]

[ "PF06435" ]

[ "DUF1079" ]

[ 82 ]

1

[]

0

[ "2qih", "6qp4" ]

2

[ "PUB00012385" ]

[ "10671460" ]

[ "The UspA1 protein and a second type of UspA2 protein mediate adherence of Moraxella catarrhalis to human epithelial cells in vitro." ]

[ 2000 ]

1

[]

0

null

[ "Moraxellaceae" ]

[ 82 ]

1

[]

0

true

Repeat

Repeat of unknown function DUF1079

DUF1079

6

IPR010495

10,495

Haem-binding HasA

HasA_haem-bd

Family

410

false

Free iron is limited in vertebrate hosts, thus an alternative to siderophores has been developed by pathogenic bacteria to access host iron bound in protein complexes. HasA is a secreted haemophore that has the ability to obtain iron from haemoglobin. Once bound to HasA, the haem is shuttled to the receptor HasR, which...

[]

0

[ "PFAM", "PIRSF" ]

[ "PF06438", "PIRSF019876" ]

[ "HasA", "HasA" ]

[ 410, 203 ]

2

[]

0

[ "1b2v", "1dk0", "1dkh", "1ybj", "2cn4", "2uyd", "3csl", "3csn", "3ddr", "3ell", "3mok", "3mol", "3mom", "3w8m", "3w8o", "3wah", "4jer", "4jes", "4jet", "4o6q", "4o6s", "4o6t", "4o6u", "4xzd", "4y1q", "4y4s", "5c58", "5iqw", "5iqx", "5xa4", "5xhl", "5xib"...

52

[ "PUB00012387" ]

[ "10360351" ]

[ "The crystal structure of HasA, a hemophore secreted by Serratia marcescens." ]

[ 1999 ]

1

[]

0

null

[ "Beauveria bassiana D1-5", "Pseudomonadota", "plant metagenome" ]

[ 1, 406, 3 ]

3

[]

0

true

Family

Haem-binding HasA

HasA_haem-bd

7

IPR010496

10,496

3-keto-alpha-glucoside-1,2-lyase/3-keto-2-hydroxy-glucal hydratase domain

AL/BT2_dom

Domain

22,318

false

This domain has structural similarity to an endo-1,3-1,4-beta glucanase belonging to glycoside hydrolase family 16 . A member containing this domain, BT2157 from B. thetaiotaomicron, was initially described as a 3-keto trehalose hydrolase involved in trehalose degradation [ ]. However, members of this group of proteins...

[ "GO:0016787" ]

[ "hydrolase activity" ]

[ "molecular_function" ]

1

[ "PFAM" ]

[ "PF06439" ]

[ "3keto-disac_hyd" ]

[ 22318 ]

1

[]

0

[ "3h3l", "3hbk", "3imm", "3nmb", "3osd", "3s5q", "3u1x", "4azz", "4b1l", "4b1m", "4hxc", "4jqt", "4qhz", "8rr2", "8tda", "8tde", "8v31", "9fbe" ]

18

[ "PUB00097337", "PUB00160473" ]

[ "33657378", "38898276" ]

[ "Functional genetics of human gut commensal Bacteroides thetaiotaomicron reveals metabolic requirements for growth across environments.", "An alternative broad-specificity pathway for glycan breakdown in bacteria." ]

[ 2021, 2024 ]

2

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Stenotrophomonas maltophilia phage vB_SmaM_Ps15", "metagenomes" ]

[ 33, 21474, 270, 1, 540 ]

5

[]

0

true

Domain

3-keto-alpha-glucoside-1,2-lyase/3-keto-2-hydroxy-glucal hydratase domain

AL/BT2_dom

5

IPR010497

10,497

Epoxide hydrolase, N-terminal

Epoxide_hydro_N

Domain

21,304

false

This entry represents the N-terminal region of the eukaryotic epoxide hydrolase protein. Epoxide hydrolases ( ) comprise a group of functionally related enzymes that catalyse the addition of water to oxirane compounds (epoxides), thereby usually generating vicinal trans-diols. EHs have been found in all types of living...

[]

0

[ "PFAM" ]

[ "PF06441" ]

[ "EHN" ]

[ 21304 ]

1

[ "EC", "REACTOME", "REACTOME", "REACTOME" ]

[ "3.3.2.9", "R-MMU-211945", "R-RNO-211945", "R-SSC-211945" ]

[ "EC:3.3.2.9", "REACTOME:R-MMU-211945", "REACTOME:R-RNO-211945", "REACTOME:R-SSC-211945" ]

4

[ "1qo7", "3g02", "3g0i", "4i19", "4qa9", "4qla", "5f4z", "6ix2", "6ix4", "8xiz" ]

10

[ "PUB00012389" ]

[ "10548561" ]

[ "Cloning and molecular characterization of a soluble epoxide hydrolase from Aspergillus niger that is related to mammalian microsomal epoxide hydrolase." ]

[ 1999 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "Stenosarchaea group", "unclassified sequences" ]

[ 10997, 10182, 38, 87 ]

4

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus" ]

[ 2, 2, 14, 1, 5, 2, 4 ]

7

true

Domain

Epoxide hydrolase, N-terminal

Epoxide_hydro_N

1

IPR010498

10,498

Fimbrial protein SefA

SefA

Family

140

false

The sefABC genes make up part of a complex sef operon responsible for the expression and assembly of SEF14 fimbriae. sefA encodes a fimbrin, the structural subunit of SEF14 fimbriae [ ]. Possession of SEF14 fimbriae alone do not appear to play a significant role in the pathogenesis of Salmonella enteritidis [ ]. This f...

[]

0

[ "NCBIFAM", "PFAM", "PIRSF" ]

[ "NF011771", "PF06443", "PIRSF020728" ]

[ "PRK15228.1", "SEF14_adhesin", "SEF14_adhesin" ]

[ 89, 140, 77 ]

3

[]

0

[]

0

[ "PUB00020321", "PUB00062137", "PUB00062138", "PUB00104973", "PUB00104974" ]

[ "10816474", "8097515", "8737493", "11577150", "9009334" ]

[ "CS22, a novel human enterotoxigenic Escherichia coli adhesin, is related to CS15.", "Characterization of three fimbrial genes, sefABC, of Salmonella enteritidis.", "Studies into the role of the SEF14 fimbrial antigen in the pathogenesis of Salmonella enteritidis.", "Genomic analysis and growth-phase-dependen...

[ 2000, 1993, 1996, 2001, 1997 ]

5

[]

0

null

[ "Enterobacteriaceae" ]

[ 140 ]

1

[]

0

true

Family

Fimbrial protein SefA

SefA

1

IPR010499

10,499

Bacterial transcription activator, effector binding

AraC_E-bd

Domain

32,857

false

This domain is found in the probable effector binding domain of a number of different bacterial transcription activators [ ] and is also present in some DNA gyrase inhibitors. The absence of a HTH motif in the DNA gyrase inhibitors is thought to indicate the fact that these do not bind DNA. It is also found in Transcri...

[]

0

[ "SMART" ]

[ "SM00871" ]

[ "AraC_E_bind" ]

[ 32857 ]

1

[]

0

[ "1d5y", "1jyh", "2kcu", "3e0h", "3gk6", "3lur", "5kat", "5kau", "5kav", "5kaw", "5kax", "5kcb", "5xbi", "5xbt", "5xbw", "5xql", "5yc9", "6wl5", "6xl5", "6xl6", "6xl9", "6xla", "6xlj", "6xlk", "7r3w", "7vwy", "7vwz", "7zhd", "7zhe", "9rtl", "9rtm" ]

31

[ "PUB00012391", "PUB00154566", "PUB00154575" ]

[ "10802742", "31501286", "18487336" ]

[ "Crystal structure of the Escherichia coli Rob transcription factor in complex with DNA.", "Multidrug Resistance Regulators MarA, SoxS, Rob, and RamA Repress Flagellar Gene Expression and Motility in Salmonella enterica Serovar Typhimurium.", "mgtA Expression is induced by rob overexpression and mediates a Salm...

[ 2000, 2019, 2008 ]

3

[]

[ "IPR029441", "IPR029442" ]

0

2

0

[ "Archaea", "Bacteria", "Caudoviricetes", "Eukaryota", "metagenomes" ]

[ 271, 32174, 2, 206, 204 ]

5

[ "Escherichia coli (strain K12)" ]

[ 3 ]

1

true

Domain

Bacterial transcription activator, effector binding

AraC_E-bd

7

IPR010500

10,500

Hepcidin

Family

940

false

Hepcidin is a antibacterial and anti-fungal protein expressed in the liver and is also a signalling molecule in iron metabolism. The hepcidin protein is cysteine-rich and forms a distorted β-sheet with an unusual disulphide bond found at the turn of the hairpin [ ].

[ "GO:0006879", "GO:0005576" ]

[ "intracellular iron ion homeostasis", "extracellular region" ]

[ "biological_process", "cellular_component" ]

2

[ "PFAM", "PANTHER" ]

[ "PF06446", "PTHR16877" ]

[ "Hepcidin", "" ]

[ 940, 782 ]

2

[]

0

[ "1m4e", "1m4f", "1s6w", "2kef", "3h0t", "4qae", "6wbv" ]

7

[ "PUB00012608" ]

[ "12138110" ]

[ "The solution structure of human hepcidin, a peptide hormone with antimicrobial activity that is involved in iron uptake and hereditary hemochromatosis." ]

[ 2002 ]

1

[]

0

null

[ "Gnathostomata", "Pseudomonas plecoglossicida" ]

[ 939, 1 ]

2

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 5, 3, 4, 3 ]

4

true

Family

Hepcidin

5

IPR010502

10,502

Carbohydrate-binding domain, family 9

Carb-bd_dom_fam9

Domain

8,506

false

This entry represents the family 9 carbohydrate-binding module (CBD9), which exhibit an immunoglobulin-like β-sandwich fold, with an additional β-strand at the N terminus [ ]. Bacterial extracellular cellulases and hemicellulases are involved in the hydrolysis of the major structural polysaccharides of plant cell walls...

[ "GO:0004553", "GO:0030246", "GO:0016052" ]

[ "hydrolase activity, hydrolyzing O-glycosyl compounds", "carbohydrate binding", "carbohydrate catabolic process" ]

[ "molecular_function", "molecular_function", "biological_process" ]

3

[ "PFAM", "PFAM" ]

[ "PF06452", "PF16011" ]

[ "CBM9_1", "CBM9_2" ]

[ 7408, 1098 ]

2

[ "EC" ]

[ "3.2.1.8" ]

[ "EC:3.2.1.8" ]

1

[ "1i82", "1i8a", "1i8u", "4jpq", "7nwn", "7nwo", "7nwp", "7nwq" ]

8

[ "PUB00015528", "PUB00015529" ]

[ "12796496", "9752722" ]

[ "Biophysical and structural analysis of a novel heme B iron ligation in the flavocytochrome cellobiose dehydrogenase.", "Structure and function analysis of Pseudomonas plant cell wall hydrolases." ]

[ 2003, 1998 ]

2

[]

[ "IPR019248" ]

0

1

0

[ "Bacteria", "Eukaryota", "Stenosarchaea group", "unclassified sequences" ]

[ 7904, 271, 57, 274 ]

4

[ "Arabidopsis thaliana" ]

[ 1 ]

1

true

Domain

Carbohydrate-binding domain, family 9

Carb-bd_dom_fam9

4

IPR010503

10,503

Type II heat-labile enterotoxin, B subunit

LT-IIB

Family

12

false

These are B subunits from the type II heat-labile enterotoxin. The B subunits form a pentameric ring, which interacts with one A subunit. Thus, the structural arrangement of type I and type II heat-labile enterotoxins are very similar [ ].

[ "GO:0005576" ]

[ "extracellular region" ]

[ "cellular_component" ]

1

[ "PFAM", "PIRSF" ]

[ "PF06453", "PIRSF019554" ]

[ "LT-IIB", "LT-IIB" ]

[ 12, 3 ]

2

[]

0

[ "1qb5", "1qcb", "1tii", "4fnf", "4fo2", "4fp5", "5g3l", "7prp", "7prs", "8guf", "8gw2", "8h2r" ]

12

[ "PUB00012611" ]

[ "8805549" ]

[ "Crystal structure of a new heat-labile enterotoxin, LT-IIb." ]

[ 1996 ]

1

[]

0

null

[ "Enterobacteriaceae", "Trichonephila clavata" ]

[ 11, 1 ]

2

[]

0

true

Family

Type II heat-labile enterotoxin, B subunit

LT-IIB

7

IPR010504

10,504

Arfaptin homology (AH) domain

AH_dom

Domain

9,933

false

The arfaptin homology (AH) domain is a protein domain found in a range of proteins, including arfaptins, protein kinase C-binding protein PICK1 [ ] and mammalian 69kDa islet cell autoantigen (ICA69) [ ]. The AH domain of arfaptin has been shown to dimerise and to bind Arf and Rho family GTPases [ , ], including ARF1, a...

[ "GO:0019904" ]

[ "protein domain specific binding" ]

[ "molecular_function" ]

1

[ "PFAM", "PROFILE", "SMART" ]

[ "PF06456", "PS50870", "SM01015" ]

[ "Arfaptin", "AH", "Arfaptin" ]

[ 9829, 9731, 9514 ]

3

[ "PROSITEDOC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "PDOC50870", "R-BTA-6811440", "R-CEL-6811440", "R-HSA-202733", "R-HSA-416993", "R-HSA-6811440", "R-MMU-416993", "R-MMU-6811440", "R-RNO-416993", "R-RNO-6811440" ]

[ "PROSITEDOC:PDOC50870", "REACTOME:R-BTA-6811440", "REACTOME:R-CEL-6811440", "REACTOME:R-HSA-202733", "REACTOME:R-HSA-416993", "REACTOME:R-HSA-6811440", "REACTOME:R-MMU-416993", "REACTOME:R-MMU-6811440", "REACTOME:R-RNO-416993", "REACTOME:R-RNO-6811440" ]

10

[ "1i49", "1i4d", "1i4l", "1i4t", "4dcn" ]

5

[ "PUB00012612", "PUB00012613", "PUB00018335", "PUB00018336" ]

[ "11346801", "12682071", "10623590", "11696355" ]

[ "The structural basis of Arfaptin-mediated cross-talk between Rac and Arf signalling pathways.", "Islet cell autoantigen of 69 kDa is an arfaptin-related protein associated with the Golgi complex of insulinoma INS-1 cells.", "Interaction of the PDZ domain of human PICK1 with class I ADP-ribosylation factors.", ...

[ 2001, 2003, 2000, 2001 ]

4

[]

[ "IPR037959" ]

0

1

0

[ "Bacteria", "Eukaryota" ]

[ 7, 9926 ]

2

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 7, 85, 5, 41, 24, 33 ]

6

true

Domain

Arfaptin homology (AH) domain

AH_dom

8

IPR010505

10,505

Molybdenum cofactor biosynthesis protein A-like, twitch domain

MoaA_twitch

Domain

27,358

false

This entry represents the iron-sulfur cluster-binding twitch domain of GTP 3',8-cyclase, which is also known as molybdenum cofactor biosynthesis protein A (MoaA) in bacteria and archaea, molybdenum cofactor biosynthesis protein 1 (MOCS1) in most eukaryotes, and molybdenum cofactor biosynthesis enzyme CNX2 in plants [ ]...

[ "GO:0051539", "GO:0006777" ]

[ "4 iron, 4 sulfur cluster binding", "Mo-molybdopterin cofactor biosynthetic process" ]

[ "molecular_function", "biological_process" ]

2

[ "PFAM", "CDD" ]

[ "PF06463", "cd21117" ]

[ "Mob_synth_C", "Twitch_MoaA" ]

[ 27338, 25592 ]

2

[ "EC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "4.1.99.22", "PWY-6823", "R-BTA-947581", "R-DDI-947581", "R-DME-947581", "R-HSA-947581", "R-MMU-947581" ]

[ "EC:4.1.99.22", "METACYC:PWY-6823", "REACTOME:R-BTA-947581", "REACTOME:R-DDI-947581", "REACTOME:R-DME-947581", "REACTOME:R-HSA-947581", "REACTOME:R-MMU-947581" ]

7

[ "1tv7", "1tv8", "2fb2", "2fb3" ]

4

[ "PUB00015124", "PUB00015126", "PUB00015635", "PUB00015921", "PUB00034757", "PUB00034758", "PUB00034759", "PUB00036007", "PUB00083471" ]

[ "15317939", "12754701", "12372836", "8528286", "12114025", "17198377", "16784786", "16632608", "25477505" ]

[ "Crystal structure of the S-adenosylmethionine-dependent enzyme MoaA and its implications for molybdenum cofactor deficiency in humans.", "Mutations in the molybdenum cofactor biosynthetic genes MOCS1, MOCS2, and GEPH.", "In vivo interactions between gene products involved in the final stages of molybdenum cofa...

[ 2004, 2003, 2002, 1995, 2002, 2007, 2006, 2006, 2015 ]

9

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 815, 21789, 4333, 421 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus",...

[ 4, 5, 2, 1, 1, 6, 1, 1, 8, 3, 3 ]

11

true

Domain

Molybdenum cofactor biosynthesis protein A-like, twitch domain

MoaA_twitch

3

IPR010506

10,506

DMAP1-binding domain

DMAP1-bd

Domain

11,049

false

This is a ~120-amino acid protein-protein interaction module that binds DMAP1 (DNA methyltransferase-associated protein 1), a transcriptional co-repressor. It is found at the N terminus of DNMT1 (DNA methyltransferase 1) [ ] and animal disco-interacting protein 2 (DIP-2), a protein that maintains morphology of mature n...

[]

0

[ "PFAM", "PROFILE", "SMART" ]

[ "PF06464", "PS51912", "SM01137" ]

[ "DMAP_binding", "DMAP1_BIND", "DMAP_binding" ]

[ 9812, 9887, 9075 ]

3

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-212300", "R-HSA-427413", "R-HSA-4655427", "R-HSA-5334118", "R-HSA-9701898", "R-HSA-9710421", "R-HSA-9725371", "R-MMU-212300", "R-MMU-4655427", "R-RNO-212300", "R-RNO-4655427" ]

[ "REACTOME:R-HSA-212300", "REACTOME:R-HSA-427413", "REACTOME:R-HSA-4655427", "REACTOME:R-HSA-5334118", "REACTOME:R-HSA-9701898", "REACTOME:R-HSA-9710421", "REACTOME:R-HSA-9725371", "REACTOME:R-MMU-212300", "REACTOME:R-MMU-4655427", "REACTOME:R-RNO-212300", "REACTOME:R-RNO-4655427" ]

11

[ "7s05", "7s06", "7s69", "8v9u", "9bgf" ]

5

[ "PUB00011312", "PUB00091614", "PUB00097528", "PUB00097529", "PUB00097530", "PUB00097531" ]

[ "10888872", "25505245", "30396999", "27908785", "23733939", "8940105" ]

[ "DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex at replication foci.", "Analysis of mucolipidosis II/III GNPTAB missense mutations identifies domains of UDP-GlcNAc:lysosomal enzyme GlcNAc-1-phosphotransferase involved in catalytic function and lysosomal enzyme recognition.", "DIP-2 suppresse...

[ 2000, 2015, 2019, 2017, 2013, 1996 ]

6

[]

0

null

[ "Bacteria", "Eukaryota" ]

[ 4, 11045 ]

2

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)" ]

[ 2, 44, 5, 24, 17, 1, 28, 1 ]

8

true

Domain

DMAP1-binding domain

DMAP1-bd

3

IPR010507

10,507

Zinc finger, MYM-type

Znf_MYM

Domain

6,921

false

MYM-type zinc fingers were identified in MYM family proteins [ ]. Human protein is involved in a chromosomal translocation and may be responsible for X-linked retardation in XQ13.1 [ ]. is also involved in disease. In myeloproliferative disorders it is fused to FGF receptor 1 [ ]; in atypical myeloproliferative disorde...

[ "GO:0008270" ]

[ "zinc ion binding" ]

[ "molecular_function" ]

1

[ "PFAM" ]

[ "PF06467" ]

[ "zf-FCS" ]

[ 6921 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-DME-2559580", "R-DME-3108214", "R-DME-3899300", "R-DME-4570464", "R-DME-8939243", "R-DME-8943724", "R-HSA-1839117", "R-HSA-5655302", "R-HSA-9703465", "R-HSA-9764725", "R-MMU-9764725" ]

[ "REACTOME:R-DME-2559580", "REACTOME:R-DME-3108214", "REACTOME:R-DME-3899300", "REACTOME:R-DME-4570464", "REACTOME:R-DME-8939243", "REACTOME:R-DME-8943724", "REACTOME:R-HSA-1839117", "REACTOME:R-HSA-5655302", "REACTOME:R-HSA-9703465", "REACTOME:R-HSA-9764725", "REACTOME:R-MMU-9764725" ]

11

[ "2das" ]

1

[ "PUB00012616", "PUB00012617", "PUB00012618", "PUB00012619", "PUB00014077", "PUB00035804", "PUB00035805", "PUB00035806", "PUB00035807", "PUB00035812" ]

[ "9716603", "8817323", "9576949", "9694738", "12665246", "17210253", "15963892", "15718139", "10529348", "11179890" ]

[ "Consistent fusion of ZNF198 to the fibroblast growth factor receptor-1 in the t(8;13)(p11;q12) myeloproliferative syndrome.", "Cloning and characterization of DXS6673E, a candidate gene for X-linked mental retardation in Xq13.1.", "Fibroblast growth factor receptor 1 is fused to FIM in stem-cell myeloprolifera...

[ 1998, 1996, 1998, 1998, 2002, 2007, 2005, 2005, 1999, 2001 ]

10

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "metagenomes" ]

[ 41, 62, 6671, 143, 4 ]

5

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 34, 9, 20, 24, 27 ]

5

true

Domain

Zinc finger, MYM-type

Znf_MYM

1

IPR010508

10,508

Neurobeachin-like, DUF1088

NBEA-like_DUF1088

Domain

5,629

false

This domain is found in the neurobeachins (NBEAs) and BEACH domain-containing proteins (BDCPs). NBEAs are localised near Golgi apparatus and are involved in vesicular trafficking, intracellular transport, membrane dynamics, endosomal recycling, and receptor signalling. BDCPs are associated with lysosome size, apoptosis...

[]

0

[ "PFAM" ]

[ "PF06469" ]

[ "DUF1088" ]

[ 5629 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-112314", "R-HSA-163615", "R-HSA-2122947", "R-HSA-9609736" ]

[ "REACTOME:R-HSA-112314", "REACTOME:R-HSA-163615", "REACTOME:R-HSA-2122947", "REACTOME:R-HSA-9609736" ]

4

[]

0

[ "PUB00098182", "PUB00098183" ]

[ "31438473", "31432443" ]

[ "Autism Spectrum Disorder-Related Syndromes: Modeling with <i>Drosophila</i> and Rodents.", "A Spectrum of Clinical Findings from ALPS to CVID: Several Novel LRBA Defects." ]

[ 2019, 2019 ]

2

[]

0

null

[ "Eukaryota" ]

[ 5629 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 60, 6, 16, 6, 6 ]

6

true

Domain

Neurobeachin-like, DUF1088

NBEA-like_DUF1088

6

IPR010510

10,510

FGF binding 1

FGF1-bd

Family

2,099

false

This family consists of several mammalian FGF binding protein 1. Fibroblast growth factors (FGFs) play important roles during foetal and embryonic development [ ]. Fibroblast growth factor-binding protein (FGF-BP) 1 is a secreted protein that can bind fibroblast growth factors (FGFs) 1 and 2 [ ].

[]

0

[ "PFAM", "PANTHER" ]

[ "PF06473", "PTHR15258" ]

[ "FGF-BP1", "" ]

[ 2099, 2043 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-190377", "R-HSA-190377", "R-MMU-190377", "R-RNO-190377" ]

[ "REACTOME:R-BTA-190377", "REACTOME:R-HSA-190377", "REACTOME:R-MMU-190377", "REACTOME:R-RNO-190377" ]

4

[]

0

[ "PUB00012625", "PUB00012626" ]

[ "11819092", "11509569" ]

[ "Immunolocalization of an FGF-binding protein reveals a widespread expression pattern during different stages of mouse embryo development.", "Enhancement of fibroblast growth factor (FGF) activity by an FGF-binding protein." ]

[ 2002, 2001 ]

2

[]

0

null

[ "Metazoa" ]

[ 2099 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 9, 3, 4, 5 ]

4

true

Family

FGF binding 1

FGF1-bd

7

IPR010511

10,511

Lytic murein transglycosylase D , lipid attachment domain

MltD_lipid-attach

Domain

784

false

This entry represents the MltD lipid attachment domain. It is a short N-terminal domain found in membrane-bound lytic murein transglycosylase D (Mltd).

[]

0

[ "PFAM" ]

[ "PF06474" ]

[ "LPAM_MltD" ]

[ 784 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria" ]

[ 784 ]

1

[]

0

true

Domain

Lytic murein transglycosylase D , lipid attachment domain

MltD_lipid-attach

4

IPR010513

10,513

KEN domain

KEN_dom

Domain

8,222

false

The proteins listed below share a common architecture with a protein kinase homology domain (see ) followed by an ~135-residue globular kinase-extension nuclease (KEN) domain made of eight helices [ ]: Mammalian 2-5A-dependent RNase or RNase L (EC 3.1.26.-), an interferon-induced enzyme implicated in both the molecular...

[ "GO:0004540", "GO:0006397" ]

[ "RNA nuclease activity", "mRNA processing" ]

[ "molecular_function", "biological_process" ]

2

[ "PFAM", "PROFILE" ]

[ "PF06479", "PS51392" ]

[ "Ribonuc_2-5A", "KEN" ]

[ 8137, 8077 ]

2

[ "EC", "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "2.7.11.1", "3.1.26.-", "R-CEL-381070", "R-DDI-381070", "R-HSA-381070", "R-HSA-8983711", "R-HSA-909733", "R-MMU-381070", "R-MMU-8983711", "R-MMU-909733", "R-SCE-381070", "R-SPO-381070" ]

[ "EC:2.7.11.1", "EC:3.1.26.-", "REACTOME:R-CEL-381070", "REACTOME:R-DDI-381070", "REACTOME:R-HSA-381070", "REACTOME:R-HSA-8983711", "REACTOME:R-HSA-909733", "REACTOME:R-MMU-381070", "REACTOME:R-MMU-8983711", "REACTOME:R-MMU-909733", "REACTOME:R-SCE-381070", "REACTOME:R-SPO-381070" ]

12

[ "2rio", "3fbv", "3lj0", "3lj1", "3lj2", "3p23", "3sdj", "3sdm", "4o1o", "4o1p", "4oau", "4oav", "4pl3", "4pl4", "4pl5", "4u6r", "4yz9", "4yzc", "4yzd", "4z7g", "4z7h", "5hgi", "6hv0", "6hx1", "6m11", "6m12", "6m13", "6urc", "6w39", "6w3a", "6w3b", "6w3c"...

44

[ "PUB00012627", "PUB00038080", "PUB00049391", "PUB00052589", "PUB00052590" ]

[ "9637683", "15385955", "18191223", "7680958", "18426919" ]

[ "A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/endoribonuclease (Ire1p) in mammalian cells.", "Structural basis for recognition of 2',5'-linked oligoadenylates by human ribonuclease L.", "Structure of the dual enzyme Ire1 reveals the basis f...

[ 1998, 2004, 2008, 1993, 2008 ]

5

[]

[ "IPR042745" ]

0

1

0

[ "Eukaryota", "marine sediment metagenome" ]

[ 8221, 1 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 14, 2, 6, 1, 8, 12, 1, 1, 10, 1, 1, 13 ]

12

true

Domain

KEN domain

KEN_dom

3

IPR010514

10,514

COX aromatic rich motif

COX_ARM

Domain

6,565

false

COX2 (Cytochrome O ubiquinol OXidase 2) is a major component of the respiratory complex during vegetative growth. It transfers electrons from a quinol to the binuclear centre of the catalytic subunit 1. The function of this region is not known.

[ "GO:0009486", "GO:0022900", "GO:0016020" ]

[ "cytochrome bo3 ubiquinol oxidase activity", "electron transport chain", "membrane" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PFAM" ]

[ "PF06481" ]

[ "COX_ARM" ]

[ 6565 ]

1

[]

0

[ "1cyw", "1cyx", "1fft", "6wti", "7cub", "7cuq", "7cuw", "7n9z", "7xmc", "7xmd", "8f68", "8f6c", "8go3", "8qqk" ]

14

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 6537, 7, 21 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Domain

COX aromatic rich motif

COX_ARM

9

IPR010515

10,515

Collagenase NC10/endostatin

Collagenase_NC10/endostatin

Domain

4,996

false

NC10 stands for Non-helical region 10 and is taken from . A mutation in this region in is associated with an increased risk of prostrate cancer. This domain is cleaved from the precursor and forms endostatin. Endostatin is a key tumour suppressor and has been used highly successfully to treat cancer. It is a potent ang...

[]

0

[ "PFAM", "CDD" ]

[ "PF06482", "cd00247" ]

[ "Endostatin", "Endostatin-like" ]

[ 4996, 2980 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-1442490", "R-HSA-1592389", "R-HSA-1650814", "R-HSA-2022090", "R-HSA-216083", "R-HSA-3000157", "R-HSA-8948216", "R-MMU-1442490", "R-MMU-1592389", "R-MMU-1650814", "R-MMU-2022090", "R-MMU-216083", "R-MMU-8948216" ]

[ "REACTOME:R-HSA-1442490", "REACTOME:R-HSA-1592389", "REACTOME:R-HSA-1650814", "REACTOME:R-HSA-2022090", "REACTOME:R-HSA-216083", "REACTOME:R-HSA-3000157", "REACTOME:R-HSA-8948216", "REACTOME:R-MMU-1442490", "REACTOME:R-MMU-1592389", "REACTOME:R-MMU-1650814", "REACTOME:R-MMU-2022090", "REACTOME...

13

[ "1bnl", "1dy0", "1dy1", "1dy2", "1koe" ]

5

[ "PUB00012630", "PUB00012631", "PUB00081684", "PUB00081685" ]

[ "11606364", "10704302", "10885579", "11191058" ]

[ "A polymorphism in endostatin, an angiogenesis inhibitor, predisposes for the development of prostatic adenocarcinoma.", "Variable zinc coordination in endostatin.", "Collagen XVIII/endostatin structure and functional role in angiogenesis.", "Angiostatin and endostatin: endogenous inhibitors of tumor growth."...

[ 2001, 2000, 2000, 2000 ]

4

[]

0

null

[ "Bacteria", "Eukaryota" ]

[ 6, 4990 ]

2

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 5, 29, 28, 7, 6, 13 ]

6

true

Domain

Collagenase NC10/endostatin

Collagenase_NC10/endostatin

5

IPR010516

10,516

Sin3 associated polypeptide p18

SAP18

Family

4,126

false

This family consists of several eukaryotic Sin3 associated polypeptide p18 (SAP18) sequences. SAP18 is known to be a component of the Sin3-containing complex, which is responsible for the repression of transcription via the modification of histone polypeptides [ ]. SAP18 is also present in the ASAP complex which is tho...

[]

0

[ "PFAM", "PANTHER" ]

[ "PF06487", "PTHR13082" ]

[ "SAP18", "" ]

[ 4120, 4004 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-CEL-72163", "R-DME-3214815", "R-DME-72163", "R-HSA-3214815", "R-HSA-427413", "R-HSA-72163", "R-HSA-9679191", "R-MMU-3214815", "R-MMU-72163", "R-SPO-3214815" ]

[ "REACTOME:R-CEL-72163", "REACTOME:R-DME-3214815", "REACTOME:R-DME-72163", "REACTOME:R-HSA-3214815", "REACTOME:R-HSA-427413", "REACTOME:R-HSA-72163", "REACTOME:R-HSA-9679191", "REACTOME:R-MMU-3214815", "REACTOME:R-MMU-72163", "REACTOME:R-SPO-3214815" ]

10

[ "2hde", "4a6q", "4a8x", "4a90" ]

4

[ "PUB00012633", "PUB00012634" ]

[ "9150135", "12665594" ]

[ "Histone deacetylases and SAP18, a novel polypeptide, are components of a human Sin3 complex.", "ASAP, a novel protein complex involved in RNA processing and apoptosis." ]

[ 1997, 2003 ]

2

[]

[ "IPR017250" ]

0

1

0

[ "Eukaryota" ]

[ 4126 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Schizosaccharomyces pombe (stra...

[ 3, 1, 1, 2, 5, 6, 1, 2, 8, 1, 17 ]

11

true

Family

Sin3 associated polypeptide p18

SAP18

4

IPR010517

10,517

Phage tail tube protein, Siphoviridae

L_lac_phage_MSP

Family

118

false

This is a family of Siphoviridae phage tail tube proteins [ , ]. This family also includes some prophages from Firmicutes.

[]

0

[ "PIRSF" ]

[ "PIRSF004357" ]

[ "L_lac_phage_MSP" ]

[ 118 ]

1

[]

0

[]

0

[ "PUB00019769", "PUB00075454" ]

[ "8892814", "23542344" ]

[ "Gene organization and transcription of a late-expressed region of a Lactococcus lactis phage.", "A conserved spiral structure for highly diverged phage tail assembly chaperones." ]

[ 1996, 2013 ]

2

[]

0

null

[ "Bacteria", "Viruses" ]

[ 4, 114 ]

2

[]

0

true

Family

Phage tail tube protein, Siphoviridae

L_lac_phage_MSP

2

IPR010518

10,518

Flagellar regulatory FleQ

FleQ

Domain

2,402

false

This domain is found at the N terminus of a subset of sigma54-dependent transcriptional activators that are involved in regulation of flagellar motility e.g. FleQ in Pseudomonas aeruginosa. It is clearly related to , but lacks the conserved aspartate residue that undergoes phosphorylation in the classic two-component s...

[]

0

[ "PFAM" ]

[ "PF06490" ]

[ "FleQ" ]

[ 2402 ]

1

[]

0

[ "4wxm", "8h5v", "8p53", "8pb9" ]

4

[]

0

[]

0

null

[ "Bacteria", "Opisthokonta", "unclassified sequences" ]

[ 2366, 4, 32 ]

3

[]

0

true

Domain

Flagellar regulatory FleQ

FleQ

8

IPR010519

10,519

Female-specific protein transformer

Tra

Family

255

false

Tra is a member of the regulatory pathway controlling female somatic sexual differentiation, regulated by Sxl. It activates dsx female-specific splicing by promoting the formation of a splicing enhancer complex which consists of tra, tra2 and sr proteins [ ].

[ "GO:0006397", "GO:0046660" ]

[ "mRNA processing", "female sex differentiation" ]

[ "biological_process", "biological_process" ]

2

[ "PFAM" ]

[ "PF06495" ]

[ "Transformer" ]

[ 255 ]

1

[]

0

[]

0

[ "PUB00077132" ]

[ "1592233" ]

[ "Interspecific comparison of the transformer gene of Drosophila reveals an unusually high degree of evolutionary divergence." ]

[ 1992 ]

1

[]

0

null

[ "Eukaryota" ]

[ 255 ]

1

[ "Danio rerio", "Drosophila melanogaster" ]

[ 2, 1 ]

2

true

Family

Female-specific protein transformer

Tra

4

IPR010520

10,520

Esterase FrsA-like

FrsA-like

Family

5,136

false

The FrsA-like family includes FrsA, an esterase found to have the α/β-hydrolase fold [ , , ]. It also includes the hydrolytic polyketide shortening protein Ayg1 from fungi [ ], 2,6-dihydropseudooxynicotine hydrolase from Paenarthrobacter nicotinovorans [ ] and Fus2 from Gibberella species [ ]. The enzyme 2,6-dihydroxy-...

[]

0

[ "PFAM" ]

[ "PF06500" ]

[ "FrsA-like" ]

[ 5136 ]

1

[ "EC", "METACYC", "METACYC", "METACYC" ]

[ "3.1.1.1", "PWY-6303", "PWY-6857", "PWY-8454" ]

[ "EC:3.1.1.1", "METACYC:PWY-6303", "METACYC:PWY-6857", "METACYC:PWY-8454" ]

4

[ "2jbw", "3mve", "3our", "4i4c", "4ywf", "5no5", "8qd1", "8qd2", "8qd3", "8qd4", "8qd7", "8qd8", "8qd9", "8qda", "8qdb" ]

15

[ "PUB00041915", "PUB00058796", "PUB00080691", "PUB00082317", "PUB00094021", "PUB00094022", "PUB00099541" ]

[ "17275835", "21623357", "15310761", "23932525", "23452154", "30951551", "28365998" ]

[ "Structure and action of a C-C bond cleaving alpha/beta-hydrolase involved in nicotine degradation.", "FrsA functions as a cofactor-independent decarboxylase to control metabolic flux.", "Hydrolytic polyketide shortening by ayg1p, a novel enzyme involved in fungal melanin biosynthesis.", "Genetic manipulation...

[ 2007, 2011, 2004, 2013, 2013, 2019, 2017 ]

7

[]

[ "IPR043423" ]

0

1

0

[ "Archaea", "Bacteria", "Eukaryota", "metagenomes" ]

[ 27, 3644, 1449, 16 ]

4

[ "Escherichia coli (strain K12)", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)" ]

[ 1, 2 ]

2

true

Family

Esterase FrsA-like

FrsA-like

6

IPR010521

10,521

Fijivirus, VP7-1-like

Fijivirus_VP7-1-like

Family

150

false

This entry contains proteins from Fijiviruses including P7-1 protein from Southern rice black-streaked dwarf virus (SRBSDV) and the probable non-structural 41.0 kDa protein from Maize rough dwarf virus (MRDV). P7-1 induces the formation of virus-containing tubules in infected plant and insect vector cells allowing its ...

[]

0

[ "PFAM" ]

[ "PF06503" ]

[ "DUF1101" ]

[ 150 ]

1

[]

0

[]

0

[ "PUB00099994", "PUB00099996" ]

[ "21671041", "33647067" ]

[ "The P7-1 protein of southern rice black-streaked dwarf virus, a fijivirus, induces the formation of tubular structures in insect cells.", "A plant reovirus hijacks endoplasmic reticulum-associated degradation machinery to promote efficient viral transmission by its planthopper vector under high temperature condi...

[ 2011, 2021 ]

2

[]

0

null

[ "Reovirales" ]

[ 150 ]

1

[]

0

true

Family

Fijivirus, VP7-1-like

Fijivirus_VP7-1-like

5

IPR010523

10,523

Activator of aromatic catabolism

XylR_N

Domain

1,931

false

This domain is found at the N terminus of a subset of sigma54-dependent transcriptional activators in several proteobacteria, including activators of phenol degradation such as XylR. It is found adjacent to .

[]

0

[ "PFAM" ]

[ "PF06505" ]

[ "XylR_N" ]

[ 1931 ]

1

[]

0

[ "5fru", "5frv", "5frw", "5frx", "5fry", "5frz", "5fs0", "5kbe", "5kbg", "5kbh", "5kbi", "6iy8", "7vqf" ]

13

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Steinernema glaseri", "ecological metagenomes" ]

[ 13, 1908, 1, 9 ]

4

[]

0

true

Domain

Activator of aromatic catabolism

XylR_N

4

IPR010524

10,524

Signal transduction response regulator, propionate catabolism activator, N-terminal

Sig_transdc_resp-reg_PrpR_N

Domain

4,831

false

Two-component signal transduction systems enable bacteria to sense, respond, and adapt to a wide range of environments, stressors, and growth conditions [ ]. Some bacteria can contain up to as many as 200 two-component systems that need tight regulation to prevent unwanted cross-talk [ ]. These pathways have been adapt...

[ "GO:0000156", "GO:0003677", "GO:0005524", "GO:0000160" ]

[ "phosphorelay response regulator activity", "DNA binding", "ATP binding", "phosphorelay signal transduction system" ]

[ "molecular_function", "molecular_function", "molecular_function", "biological_process" ]

4

[ "PFAM" ]

[ "PF06506" ]

[ "PrpR_N" ]

[ 4831 ]

1

[]

0

[ "2pju", "2q5c" ]

2

[ "PUB00010651", "PUB00011096", "PUB00042804", "PUB00042805", "PUB00042806", "PUB00042807", "PUB00042902" ]

[ "12372152", "10966457", "16176121", "18076326", "11934609", "11489844", "15528672" ]

[ "Histidine protein kinases: key signal transducers outside the animal kingdom.", "Two-component signal transduction.", "Two-component signal transduction pathways regulating growth and cell cycle progression in a bacterium: a system-level analysis.", "Specificity in two-component signal transduction pathways....

[ 2002, 2000, 2005, 2007, 2002, 2001, 2004 ]

7

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 4795, 3, 33 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Domain

Signal transduction response regulator, propionate catabolism activator, N-terminal

Sig_transdc_resp-reg_PrpR_N

9

IPR010525

10,525

Auxin response factor domain

ARF_dom

Domain

15,906

false

This entry represents the C-terminal conserved domain of auxin-responsive transcription factors. The plant hormone auxin (indole-3-acetic acid) can regulate the gene expression of several families, including Aux/IAA, GH3 and SAUR families. Two related families of proteins, Aux/IAA proteins ( ) and the auxin response fa...

[ "GO:0003677", "GO:0006355", "GO:0009725", "GO:0005634" ]

[ "DNA binding", "regulation of DNA-templated transcription", "response to hormone", "nucleus" ]

[ "molecular_function", "biological_process", "biological_process", "cellular_component" ]

4

[ "PFAM" ]

[ "PF06507" ]

[ "ARF_AD" ]

[ 15906 ]

1

[]

0

[ "4ldu", "4ldv", "4ldw", "4ldx", "4ldy", "6sdg", "6ycq", "8oj1", "8oj2" ]

9

[ "PUB00014766" ]

[ "12036262" ]

[ "Genetics of Aux/IAA and ARF action in plant growth and development." ]

[ 2002 ]

1

[]

0

null

[ "Eukaryota" ]

[ 15906 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 191, 54, 302 ]

3

true

Domain

Auxin response factor domain

ARF_dom

3

IPR010526

10,526

Sodium ion transport-associated domain

Na_trans_assoc_dom

Domain

15,005

false

This entry represents a domain specific to animal sodium channels or their subunits, many of which are voltage-gated. Members very often also contain between one and four copies of and, less often, one copy of . This domain shows a helical structure [ , ].

[ "GO:0005248", "GO:0006814", "GO:0001518" ]

[ "voltage-gated sodium channel activity", "sodium ion transport", "voltage-gated sodium channel complex" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PFAM" ]

[ "PF06512" ]

[ "Na_trans_assoc" ]

[ 15005 ]

1

[ "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-445095", "R-HSA-5576892", "R-HSA-9717207" ]

[ "REACTOME:R-HSA-445095", "REACTOME:R-HSA-5576892", "REACTOME:R-HSA-9717207" ]

3

[ "5xsy", "6agf", "6j8e", "6j8g", "6j8h", "6j8i", "6j8j", "6lqa", "6uz0", "6uz3", "7dtc", "7dtd", "7fbs", "7k18", "7tj8", "7tj9", "7w77", "7w7f", "7w9k", "7w9l", "7w9m", "7w9p", "7w9t", "7we4", "7wel", "7wfr", "7wfw", "7xm9", "7xmf", "7xmg", "7xsu", "7xve"...

60

[ "PUB00103880", "PUB00103881" ]

[ "30190309", "28735751" ]

[ "Structure of the human voltage-gated sodium channel Nav1.4 in complex with β1.", "Structure of the Na<sub>v</sub>1.4-β1 Complex from Electric Eel." ]

[ 2018, 2017 ]

2

[]

0

null

[ "Bilateria" ]

[ 15005 ]

1

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 47, 51, 49, 49, 53 ]

5

true

Domain

Sodium ion transport-associated domain

Na_trans_assoc_dom

6

IPR010527

10,527

Photosystem II PsbU, oxygen evolving complex

PSII_PsbU

Family

627

false

In PSII, the oxygen-evolving complex (OEC) is responsible for catalysing the splitting of water to O(2) and 4H+. The OEC is composed of a cluster of manganese, calcium and chloride ions bound to extrinsic proteins. In cyanobacteria there are five extrinsic proteins in OEC (PsbO, PsbP-like, PsbQ-like, PsbU and PsbV), wh...

[ "GO:0015979", "GO:0042549", "GO:0009523", "GO:0009654", "GO:0019898" ]

[ "photosynthesis", "photosystem II stabilization", "photosystem II", "photosystem II oxygen evolving complex", "extrinsic component of membrane" ]

[ "biological_process", "biological_process", "cellular_component", "cellular_component", "cellular_component" ]

5

[ "HAMAP", "PFAM" ]

[ "MF_00589", "PF06514" ]

[ "PSII_PsbU", "PsbU" ]

[ 352, 627 ]

2

[ "GP" ]

[ "GenProp0661" ]

[ "GP:GenProp0661" ]

1

[ "1s5l", "2axt", "3a0b", "3a0h", "3kzi", "3wu2", "4fby", "4il6", "4ixq", "4ixr", "4pbu", "4pj0", "4rvy", "4tnh", "4tni", "4tnj", "4tnk", "4ub6", "4ub8", "4v62", "4v82", "4yuu", "5b5e", "5b66", "5e79", "5e7c", "5gth", "5gti", "5h2f", "5kaf", "5kai", "5mx2"...

121

[ "PUB00012636", "PUB00015357", "PUB00015358", "PUB00015359", "PUB00015369", "PUB00097583", "PUB00152828" ]

[ "10318707", "12518057", "15100025", "14871485", "15258264", "30076221", "33846594" ]

[ "PsbU, a protein associated with photosystem II, is required for the acquisition of cellular thermotolerance in synechococcus species PCC 7002", "Crystal structure of oxygen-evolving photosystem II from Thermosynechococcus vulcanus at 3.7-A resolution.", "The evolutionary development of the protein complement o...

[ 1999, 2003, 2004, 2004, 2004, 2018, 2021 ]

7

[]

0

null

[ "Bacteria", "Eukaryota", "anaerobic digester metagenome" ]

[ 379, 247, 1 ]

3

[]

0

true

Family

Photosystem II PsbU, oxygen evolving complex

PSII_PsbU

2

IPR010530

10,530

NADH-ubiquinone reductase complex 1 MLRQ subunit

B12D

Family

7,140

false

The MLRQ subunit of mitochondrial NADH-ubiquinone reductase complex I is nuclear [ ] and is found in plants [ ], insects, fungi and higher metazoans [ ]. It appears to act within the membrane and, in mammals, is highly expressed in muscle and neural tissue, indicative of a role in ATP generation [ ].

[]

0

[ "PFAM", "PANTHER" ]

[ "PF06522", "PTHR14256" ]

[ "B12D", "" ]

[ 7133, 3588 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-5628897", "R-BTA-611105", "R-BTA-9707564", "R-BTA-9864848", "R-DRE-5628897", "R-DRE-611105", "R-DRE-9707564", "R-HSA-5628897", "R-HSA-611105", "R-HSA-9707564", "R-HSA-9864848", "R-MMU-5628897", "R-MMU-611105", "R-MMU-9707564", "R-MMU-9864848" ]

[ "REACTOME:R-BTA-5628897", "REACTOME:R-BTA-611105", "REACTOME:R-BTA-9707564", "REACTOME:R-BTA-9864848", "REACTOME:R-DRE-5628897", "REACTOME:R-DRE-611105", "REACTOME:R-DRE-9707564", "REACTOME:R-HSA-5628897", "REACTOME:R-HSA-611105", "REACTOME:R-HSA-9707564", "REACTOME:R-HSA-9864848", "REACTOME:R...

15

[ "5z62", "8ugh", "8ugi", "8ugj", "8ugl", "8ugn", "8ugr" ]

7

[ "PUB00012640", "PUB00019330", "PUB00043559" ]

[ "11473698", "1518044", "15843018" ]

[ "Stability of barley aleurone transcripts: Dependence on protein synthesis, influence of the starchy endosperm and destabilization by GA3.", "Sequences of 20 subunits of NADH:ubiquinone oxidoreductase from bovine heart mitochondria. Application of a novel strategy for sequencing proteins using the polymerase chai...

[ 2001, 1992, 2005 ]

3

[]

0

null

[ "Actinomycetes", "Eukaryota", "Nucleocytoviricota" ]

[ 3, 7135, 2 ]

3

[ "Arabidopsis thaliana", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "...

[ 7, 7, 1, 4, 6, 1, 17, 9, 1, 2, 16 ]

11

true

Family

NADH-ubiquinone reductase complex 1 MLRQ subunit

B12D

2

IPR010531

10,531

Zinc finger protein NOA36

NOA36

Family

2,060

false

This family consists of several NOA36 proteins (also known as zinc finger protein 330) which contain 29 highly conserved cysteine residues. In mitosis it associates with centromeres and concentrates at the midbody in cytokinesis [ ].

[ "GO:0008270", "GO:0005634" ]

[ "zinc ion binding", "nucleus" ]

[ "molecular_function", "cellular_component" ]

2

[ "PFAM", "PANTHER" ]

[ "PF06524", "PTHR13214" ]

[ "NOA36", "" ]

[ 2054, 2044 ]

2

[]

0

[]

0

[ "PUB00066691" ]

[ "10593942" ]

[ "Molecular cloning of a zinc finger autoantigen transiently associated with interphase nucleolus and mitotic centromeres and midbodies. Orthologous proteins with nine CXXC motifs highly conserved from nematodes to humans." ]

[ 1999 ]

1

[]

0

null

[ "Eukaryota" ]

[ 2060 ]

1

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 1, 8, 2, 4 ]

5

true

Family

Zinc finger protein NOA36

NOA36

8

IPR010532

10,532

Sulfocyanin

SoxE

Family

88

false

Members of this family are blue-copper redox proteins designated sulfocyanin, mainly from the archaeal genera Sulfolobus [ ]. Sulfocyanin is a component of the respiratory supercomplex SoxM [ ].

[ "GO:0005507" ]

[ "copper ion binding" ]

[ "molecular_function" ]

1

[ "PIRSF", "NCBIFAM" ]

[ "PIRSF022145", "TIGR03094" ]

[ "Sulfocyanin", "sulfo_cyanin" ]

[ 78, 78 ]

2

[]

0

[]

0

[ "PUB00020360", "PUB00043051" ]

[ "11163357", "12530544" ]

[ "Sulfocyanin and subunit II, two copper proteins with novel features, provide new insight into the archaeal SoxM oxidase supercomplex.", "The archaeal respiratory supercomplex SoxM from S. acidocaldarius combines features of quinole and cytochrome c oxidases." ]

[ 2001, 2002 ]

2

[]

0

null

[ "Archaea" ]

[ 88 ]

1

[]

0

true

Family

Sulfocyanin

SoxE

5

IPR010535

10,535

Protein of unknown function DUF1110

DUF1110

Family

314

false

This entry contains proteins with no known function at present, found in the Poaceae (true grasses).

[]

0

[ "PFAM", "PANTHER" ]

[ "PF06533", "PTHR35356" ]

[ "DUF1110", "" ]

[ 304, 303 ]

2

[]

0

[ "7x8v" ]

1

[]

0

[]

0

null

[ "Poaceae" ]

[ 314 ]

1

[ "Oryza sativa subsp. japonica", "Zea mays" ]

[ 24, 4 ]

2

true

Family

Protein of unknown function DUF1110

DUF1110

2

IPR010536

10,536

Repulsive guidance molecule, N-terminal

RGM_N

Domain

3,115

false

This entry represents the N-terminal domain of repulsive guidance molecule (RGM), mainly found in animals. RGM is a GPI-linked axon guidance molecule of the retinotectal system, and controls cell motility, adhesion, immune cell regulation and systemic iron metabolism [ , ]. RGM is repulsive for a subset of axons, those...

[]

0

[ "PFAM" ]

[ "PF06535" ]

[ "RGM_N" ]

[ 3115 ]

1

[ "REACTOME" ]

[ "R-HSA-373752" ]

[ "REACTOME:R-HSA-373752" ]

1

[ "4bq6", "4bq7", "4bq8", "4uhy", "4uhz", "4ui0", "4ui1", "4ui2", "6z3g", "6z3h", "6z3j", "6z3l", "6z3m", "7ndg" ]

14

[ "PUB00012643", "PUB00079264", "PUB00100686" ]

[ "12353034", "25938661", "33740419" ]

[ "RGM is a repulsive guidance molecule for retinal axons.", "Repulsive guidance molecule is a structural bridge between neogenin and bone morphogenetic protein.", "Simultaneous binding of Guidance Cues NET1 and RGM blocks extracellular NEO1 signaling." ]

[ 2002, 2015, 2021 ]

3

[]

0

null

[ "Metazoa" ]

[ 3115 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 6, 9, 9, 11 ]

5

true

Domain

Repulsive guidance molecule, N-terminal

RGM_N

5

IPR010537

10,537

Avian adenovirus fibre, N-terminal

Avian_adenovirus_fibre_N

Domain

255

false

This entry represents the N-terminal domain of the avian adenovirus fibre proteins, which have been linked to variations in virulence [ ]. Avian adenoviruses possess penton capsomers that consist of a pentameric base associated with two fibres [ ].

[ "GO:0019062" ]

[ "virion attachment to host cell" ]

[ "biological_process" ]

1

[ "PFAM" ]

[ "PF06536" ]

[ "Av_adeno_fibre" ]

[ 255 ]

1

[]

0

[]

0

[ "PUB00012644", "PUB00012645" ]

[ "8764019", "7563058" ]

[ "A single gene encoding the fiber is responsible for variations in virulence in the fowl adenoviruses.", "The avian adenovirus penton: two fibres and one base." ]

[ 1996, 1995 ]

2

[]

0

null

[ "Adenoviridae", "Fungi incertae sedis", "Gammaproteobacteria", "metagenomes" ]

[ 246, 2, 3, 4 ]

4

[]

0

true

Domain

Avian adenovirus fibre, N-terminal

Avian_adenovirus_fibre_N

4

IPR010538

10,538

Di-haem oxidoreductase, putative peroxidase

DHOR

Family

5,310

false

DHOR is a family of di-haem oxidoredictases. It carries the two characteristic Cys-X-Y-Cys-His haem-binding motifs. The C-terminal high-potential site functions as an electron transfer centre, and the N-terminal low-potential site corresponds to the peroxidatic centre. Its probable function is as a peroxidase [ ].

[]

0

[ "PFAM", "PIRSF" ]

[ "PF06537", "PIRSF028099" ]

[ "DHOR", "DUF1111" ]

[ 5310, 3928 ]

2

[]

0

[]

0

[ "PUB00075353" ]

[ "20537955" ]

[ "The challenge of annotating protein sequences: The tale of eight domains of unknown function in Pfam." ]

[ 2010 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 5238, 5, 67 ]

3

[]

0

true

Family

Di-haem oxidoreductase, putative peroxidase

DHOR

5

IPR010539

10,539

Bax inhibitor 1 like

BaxI_1-like

Family

6,637

false

This entry represents a group of Bax-inhibitor-1 sequences that is conserved from bacteria to humans [ , ].

[]

0

[ "PFAM", "PIRSF", "PANTHER" ]

[ "PF12811", "PIRSF009160", "PTHR41282" ]

[ "BaxI_1", "UCP009160", "" ]

[ 6637, 5658, 6600 ]

3

[]

0

[]

0

[ "PUB00055593", "PUB00055594" ]

[ "12875974", "18440869" ]

[ "Bax inhibitor-1 is overexpressed in prostate cancer and its specific down-regulation by RNA interference leads to cell death in human prostate carcinoma cells.", "Comparative genomics and function analysis on BI1 family." ]

[ 2003, 2008 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "Methanobacteriati", "metagenomes" ]

[ 6319, 29, 30, 259 ]

4

[]

0

true

Family

Bax inhibitor 1 like

BaxI_1-like

5

IPR010540

10,540

Putative ABC-transporter type IV CmpB/TMEM229

CmpB_TMEM229

Family

6,235

false

This entry includes a group of transmembrane proteins, including CmpB from bacteria and TMEM229 from animals.

[]

0

[ "PFAM" ]

[ "PF06541" ]

[ "ABC_trans_CmpB" ]

[ 6235 ]

1

[]

0

[]

0

[ "PUB00075439" ]

[ "18504552" ]

[ "Detection and characterization of an ABC transporter in Clostridium hathewayi." ]

[ 2008 ]

1

[]

0

null

[ "Bacteria", "Methanocorpusculum", "Opisthokonta", "Viruses", "metagenomes" ]

[ 4894, 2, 1271, 20, 48 ]

5

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 2, 1, 3 ]

4

true

Family

Putative ABC-transporter type IV CmpB/TMEM229

CmpB_TMEM229

8

IPR010541

10,541

Small nuclear ribonucleoprotein Prp3, C-terminal domain

Prp3_C

Domain

8,118

false

This domain is found at the C-terminal end of U4/U6 and U4/U5/U6-small nuclear ribonucleoprotein Prp3, part of the tri-RNA complex that form the spliceosome. Prp3 plays a key role in the recognition of the snRNA duplex. Defects in PRPF3 are the cause of retinitis pigmentosa type 18 (RP18). RP leads to degeneration of r...

[]

0

[ "PFAM" ]

[ "PF06544" ]

[ "Prp3_C" ]

[ 8118 ]

1

[ "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-72163", "R-MMU-3065678", "R-MMU-72163" ]

[ "REACTOME:R-HSA-72163", "REACTOME:R-MMU-3065678", "REACTOME:R-MMU-72163" ]

3

[ "3jcm", "3jcr", "4yhu", "4yhv", "4yhw", "5gan", "5gap", "5nrl", "5o9z", "5zwm", "5zwo", "6ah0", "6ahd", "6qw6", "6qx9", "8h6e", "8h6j", "8h6k", "8h6l", "8q7n", "8qo9", "8qoz", "8qp8", "8qp9", "8qpa", "8qpb", "8qpe", "8qxd", "8qzs", "8r08", "8r09", "8r0a"...

35

[ "PUB00033315", "PUB00062917", "PUB00062918", "PUB00083217", "PUB00100664", "PUB00100665", "PUB00100666", "PUB00100667" ]

[ "11773002", "12714658", "17932117", "24068953", "26161500", "26912367", "26743623", "26829225" ]

[ "Mutations in HPRP3, a third member of pre-mRNA splicing factor genes, implicated in autosomal dominant retinitis pigmentosa.", "Mutations in the pre-mRNA splicing-factor genes PRPF3, PRPF8, and PRPF31 in Spanish families with autosomal dominant retinitis pigmentosa.", "Mutation in the splicing factor Hprp3p li...

[ 2002, 2003, 2008, 2013, 2015, 2016, 2016, 2016 ]

8

[]

[ "IPR059181" ]

0

1

0

[ "Eukaryota" ]

[ 8118 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 10, 1, 6, 3, 10, 6, 1, 4, 10, 1, 1, 12 ]

12

true

Domain

Small nuclear ribonucleoprotein Prp3, C-terminal domain

Prp3_C

3

IPR010542

10,542

Vertebrate heat shock transcription factor, C-terminal domain

Vert_HSTF_C

Domain

3,680

false

This domain represents the C-terminal region of vertebrate heat shock transcription factors. Heat shock transcription factors regulate the expression of heat shock proteins - a set of proteins that protect the cell from damage caused by stress and aid the cell's recovery after the removal of stress [ ]. This C-terminal...

[ "GO:0003677", "GO:0003700", "GO:0006355" ]

[ "DNA binding", "DNA-binding transcription factor activity", "regulation of DNA-templated transcription" ]

[ "molecular_function", "molecular_function", "biological_process" ]

3

[ "PFAM" ]

[ "PF06546" ]

[ "Vert_HS_TF" ]

[ 3680 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-3371453", "R-BTA-3371511", "R-BTA-3371568", "R-BTA-3371571", "R-BTA-9841251", "R-DME-3371453", "R-DME-3371511", "R-DME-3371568", "R-DME-3371571", "R-DME-9841251", "R-HSA-3371453", "R-HSA-3371511", "R-HSA-3371568", "R-HSA-3371571", "R-HSA-9646399", "R-HSA-9841251", "R-MMU-33714...

[ "REACTOME:R-BTA-3371453", "REACTOME:R-BTA-3371511", "REACTOME:R-BTA-3371568", "REACTOME:R-BTA-3371571", "REACTOME:R-BTA-9841251", "REACTOME:R-DME-3371453", "REACTOME:R-DME-3371511", "REACTOME:R-DME-3371568", "REACTOME:R-DME-3371571", "REACTOME:R-DME-9841251", "REACTOME:R-HSA-3371453", "REACTOM...

21

[]

0

[ "PUB00012647" ]

[ "11509572" ]

[ "The DNA-binding domain of yeast heat shock transcription factor independently regulates both the N- and C-terminal activation domains." ]

[ 2001 ]

1

[]

0

null

[ "Bilateria" ]

[ 3680 ]

1

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 7, 7, 10, 13, 17 ]

5

true

Domain

Vertebrate heat shock transcription factor, C-terminal domain

Vert_HSTF_C

6

IPR010543

10,543

Domain of unknown function DUF1117

DUF1117

Domain

1,698

false

This entry represents the C terminus of a number of hypothetical plant proteins.

[]

0

[ "PFAM" ]

[ "PF06547" ]

[ "DUF1117" ]

[ 1698 ]

1

[ "EC", "METACYC" ]

[ "2.3.2.27", "PWY-7511" ]

[ "EC:2.3.2.27", "METACYC:PWY-7511" ]

2

[]

0

[]

0

[]

0

null

[ "Spermatophyta" ]

[ 1698 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 15, 8, 10 ]

3

true

Domain

Domain of unknown function DUF1117

DUF1117

7

IPR010545

10,545

Signal-peptide peptidase, presenilin aspartyl protease, archaea

SPP_arch

Family

677

false

This entry contains putative SPP, which are signal-peptide aspartyl proteases. The family carries the characteristic catalytic aspartate GXGD motif, and members are integral membrane peptidases of the presenilin-type with nine transmembrane regions. This entry includes PSH from Methanoculleus marisnigri (Memar_1924, ),...

[]

0

[ "NCBIFAM", "PFAM" ]

[ "NF041679", "PF06550" ]

[ "IMP_arch_presen", "SPP" ]

[ 555, 677 ]

2

[]

0

[ "4hyc", "4hyd", "4hyg", "4y6k" ]

4

[ "PUB00065205", "PUB00152957", "PUB00161730" ]

[ "23254940", "25733893", "38824390" ]

[ "Structure of a presenilin family intramembrane aspartate protease.", "Cleavage of amyloid precursor protein by an archaeal presenilin homologue PSH.", "SANS reveals lipid-dependent oligomerization of an intramembrane aspartyl protease from H. volcanii." ]

[ 2013, 2015, 2024 ]

3

[ "IPR006639" ]

[]

1

0

1

[ "Archaea", "Bacteria", "ecological metagenomes" ]

[ 580, 70, 27 ]

3

[]

0

true

Family

Signal-peptide peptidase, presenilin aspartyl protease, archaea

SPP_arch

2

IPR010546

10,546

Protein of unknown function DUF1120

DUF1120

Family

2,696

false

This family consists of several bacterial proteins, at least one of which is involved in enzyme induction following nitrogen deprivation. The exact function of this family is unknown

[]

0

[ "PFAM" ]

[ "PF06551" ]

[ "DUF1120" ]

[ 2696 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Ancylostoma caninum", "Bacteria" ]

[ 1, 2695 ]

2

[ "Escherichia coli (strain K12)" ]

[ 2 ]

1

true

Family

Protein of unknown function DUF1120

DUF1120

5

IPR010547

10,547

Plant specific mitochondrial import receptor subunit TOM20

TOM20_imprt_rcpt

Family

1,414

false

This family consists of several plant specific mitochondrial import receptor subunit TOM20 (translocase of outer membrane 20kDa subunit) proteins. Most mitochondrial proteins are encoded by the nuclear genome, and are synthesised in the cytosol. TOM20 is a general import receptor that binds to mitochondrial pre-sequenc...

[ "GO:0045040", "GO:0005742" ]

[ "protein insertion into mitochondrial outer membrane", "mitochondrial outer membrane translocase complex" ]

[ "biological_process", "cellular_component" ]

2

[ "PANTHER" ]

[ "PTHR32409" ]

[ "" ]

[ 1414 ]

1

[]

0

[ "1zu2" ]

1

[ "PUB00012650" ]

[ "12691756" ]

[ "Peptide library approach with a disulfide tether to refine the Tom20 recognition motif in mitochondrial presequences." ]

[ 2003 ]

1

[]

0

null

[ "Eukaryota", "Pseudomonadota" ]

[ 1411, 3 ]

2

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 17, 1, 13 ]

3

true

Family

Plant specific mitochondrial import receptor subunit TOM20

TOM20_imprt_rcpt

6

IPR010548

10,548

BNIP3

Family

3,633

false

This family consists of several mammalian specific BCL2/adenovirus E1B 19kDa protein-interacting protein 3 or BNIP3 sequences. BNIP3 belongs to the Bcl-2 homology 3 (BH3)-only family, a Bcl-2-related family possessing an atypical Bcl-2 homology 3 (BH3) domain, which regulates PCD from mitochondrial sites by selective B...

[ "GO:0043065", "GO:0005740", "GO:0016020" ]

[ "positive regulation of apoptotic process", "mitochondrial envelope", "membrane" ]

[ "biological_process", "cellular_component", "cellular_component" ]

3

[ "PFAM", "PANTHER" ]

[ "PF06553", "PTHR15186" ]

[ "BNIP3", "" ]

[ 3623, 3505 ]

2

[ "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-6803204", "R-HSA-6803204", "R-MMU-6803204" ]

[ "REACTOME:R-BTA-6803204", "REACTOME:R-HSA-6803204", "REACTOME:R-MMU-6803204" ]

3

[ "2j5d", "2ka1", "2ka2" ]

3

[ "PUB00012651" ]

[ "12690108" ]

[ "CD47 and the 19 kDa interacting protein-3 (BNIP3) in T cell apoptosis." ]

[ 2003 ]

1

[]

0

null

[ "Eumetazoa" ]

[ 3633 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 7, 4, 12, 6, 15 ]

6

true

Family

BNIP3

5

IPR010549

10,549

African swine fever virus, IAP-like p27, C-terminal

ASFV_p27_C

Domain

26

false

This entry represents the C-terminal region of the African swine fever virus (ASFV) IAP-like protein p27. This domain is found in conjunction with . It has been suggested that the domain may be incoded by the gene involved in aspects of infection in the arthropod host, ticks of the genus Ornithodoros [ ].

[]

0

[ "PFAM" ]

[ "PF06556" ]

[ "ASFV_p27" ]

[ 26 ]

1

[]

0

[]

0

[ "PUB00012652" ]

[ "9143281" ]

[ "A BIR motif containing gene of African swine fever virus, 4CL, is nonessential for growth in vitro and viral virulence." ]

[ 1997 ]

1

[]

0

null

[ "African swine fever virus", "Ochromonas danica" ]

[ 25, 1 ]

2

[]

0

true

Domain

African swine fever virus, IAP-like p27, C-terminal

ASFV_p27_C

5

IPR010550

10,550

2'-deoxycytidine 5'-triphosphate deaminase, N-terminal domain

DCD_N

Domain

2,142

false

This entry includes several bacterial 2'-deoxycytidine 5'-triphosphate deaminase proteins ( ) (DCD) from a set of mainly alphaproteobacteria, which consist of two dUTPase-like domains ( ). This entry represents the N-terminal catalytic domain, which contains the active site residues Arg115 and Glu138, important for its...

[ "GO:0008829", "GO:0009394" ]

[ "dCTP deaminase activity", "2'-deoxyribonucleotide metabolic process" ]

[ "molecular_function", "biological_process" ]

2

[ "PFAM" ]

[ "PF06559" ]

[ "DCD_N" ]

[ 2142 ]

1

[]

0

[ "2r9q" ]

1

[ "PUB00038355" ]

[ "15539408" ]

[ "Structures of dCTP deaminase from Escherichia coli with bound substrate and product: reaction mechanism and determinants of mono- and bifunctionality for a family of enzymes." ]

[ 2005 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 2098, 8, 36 ]

3

[]

0

true

Domain

2'-deoxycytidine 5'-triphosphate deaminase, N-terminal domain

DCD_N

9

IPR010551

10,551

Glucose-6-phosphate isomerase, prokaryote

G6P_isomerase_prok

Domain

1,627

false

This entry consists of several bacterial and archaeal glucose-6-phosphate isomerase (GPI) proteins ( ), which are involved in glycolysis and in gluconeogenesis and catalyse the conversion of D-glucose 6-phosphate to D-fructose 6-phosphate. The deduced amino acid sequence of the first archaeal PGI isolated from Pyrococc...

[ "GO:0004347", "GO:0006094", "GO:0006096", "GO:0005737" ]

[ "glucose-6-phosphate isomerase activity", "gluconeogenesis", "glycolytic process", "cytoplasm" ]

[ "molecular_function", "biological_process", "biological_process", "cellular_component" ]

4

[ "PFAM" ]

[ "PF06560" ]

[ "GPI" ]

[ 1627 ]

1

[ "EC", "GP", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC" ]

[ "5.3.1.9", "GenProp0120", "PWY-3801", "PWY-5054", "PWY-5384", "PWY-5514", "PWY-5659", "PWY-6142", "PWY-621", "PWY-622", "PWY-6981", "PWY-6992", "PWY-7238", "PWY-7347", "PWY-7385", "PWY-8013" ]

[ "EC:5.3.1.9", "GP:GenProp0120", "METACYC:PWY-3801", "METACYC:PWY-5054", "METACYC:PWY-5384", "METACYC:PWY-5514", "METACYC:PWY-5659", "METACYC:PWY-6142", "METACYC:PWY-621", "METACYC:PWY-622", "METACYC:PWY-6981", "METACYC:PWY-6992", "METACYC:PWY-7238", "METACYC:PWY-7347", "METACYC:PWY-7385"...

16

[ "1j3p", "1j3q", "1j3r", "1qxj", "1qxr", "1qy4", "1x7n", "1x82", "1x8e", "2gc0", "2gc1", "2gc2", "2gc3", "3sxw", "4lta", "4luk", "4lul", "4lum" ]

18

[ "PUB00014844" ]

[ "11533028" ]

[ "The phosphoglucose isomerase from the hyperthermophilic archaeon Pyrococcus furiosus is a unique glycolytic enzyme that belongs to the cupin superfamily." ]

[ 2001 ]

1

[]

0

null

[ "Archaea", "Bacillus phage SP-15", "Bacteria", "Discina gigas", "metagenomes" ]

[ 244, 1, 1342, 1, 39 ]

5

[]

0

true

Domain

Glucose-6-phosphate isomerase, prokaryote

G6P_isomerase_prok

4

IPR010555

10,555

CSPG5, sulphate attachment domain

CSPG5_S_attach_dom

Domain

482

false

This entry represents the chondroitin sulphate attachment domain of Chondroitin sulfate proteoglycan 5 (CSPG5, also known as CALEB), which mediates dendritic tree and spine complexity [ ]. This domain contains several potential sites of chondroitin sulphate attachment, as well as potential sites of N-linked glycosylati...

[]

0

[ "PFAM" ]

[ "PF06566" ]

[ "Chon_Sulph_att" ]

[ 482 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-1971475", "R-HSA-2022870", "R-HSA-2022923", "R-HSA-2024101", "R-HSA-3560783", "R-HSA-3560801", "R-HSA-3595172", "R-HSA-3595174", "R-HSA-3595177", "R-HSA-4420332", "R-MMU-1971475", "R-MMU-2022870", "R-MMU-2022923", "R-MMU-2024101", "R-RNO-1971475", "R-RNO-2022870", "R-RNO-20229...

[ "REACTOME:R-HSA-1971475", "REACTOME:R-HSA-2022870", "REACTOME:R-HSA-2022923", "REACTOME:R-HSA-2024101", "REACTOME:R-HSA-3560783", "REACTOME:R-HSA-3560801", "REACTOME:R-HSA-3595172", "REACTOME:R-HSA-3595174", "REACTOME:R-HSA-3595177", "REACTOME:R-HSA-4420332", "REACTOME:R-MMU-1971475", "REACTOM...

18

[]

0

[ "PUB00012655", "PUB00084980" ]

[ "9950058", "17431398" ]

[ "Cloning and chromosomal mapping of the human gene of neuroglycan C (NGC), a neural transmembrane chondroitin sulfate proteoglycan with an EGF module.", "The neural EGF family member CALEB/NGC mediates dendritic tree and spine complexity." ]

[ 1998, 2007 ]

2

[]

0

null

[ "Euteleostomi" ]

[ 482 ]

1

[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 3, 1, 5 ]

3

true

Domain

CSPG5, sulphate attachment domain

CSPG5_S_attach_dom

2

IPR010557

10,557

Protein of unknown function DUF1133

DUF1133

Family

761

false

This family consists of a number of hypothetical proteins from Escherichia coli O157:H7 and Salmonella typhi. The function of this family is unknown.

[]

0

[ "PFAM" ]

[ "PF06576" ]

[ "DUF1133" ]

[ 761 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "human gut metagenome", "unclassified Caudoviricetes" ]

[ 758, 1, 2 ]

3

[]

0

true

Family

Protein of unknown function DUF1133

DUF1133

8

IPR010558

10,558

Caenorhabditis elegans ly-6-related

Ly-6-related

Family

1,075

false

This family consists of several Caenorhabditis elegans specific ly-6-related HOT and ODR proteins. These proteins are involved in the olfactory system. Odr-2 mutants are known to be defective in the ability to chemotax to odorants that are recognised by the two AWC olfactory neurons. Odr-2 encodes a membrane-associated...

[]

0

[ "PFAM", "PANTHER" ]

[ "PF06579", "PTHR34722" ]

[ "Ly-6_related", "" ]

[ 1057, 948 ]

2

[]

0

[]

0

[ "PUB00012657" ]

[ "11139503" ]

[ "The Caenorhabditis elegans odr-2 gene encodes a novel Ly-6-related protein required for olfaction." ]

[ 2001 ]

1

[]

0

null

[ "Ecdysozoa" ]

[ 1075 ]

1

[ "Caenorhabditis elegans" ]

[ 19 ]

1

true

Family

Caenorhabditis elegans ly-6-related

Ly-6-related

5

IPR010559

10,559

Signal transduction histidine kinase, internal region

Sig_transdc_His_kin_internal

Domain

70,678

false

This entry represents a region within bacterial histidine kinase enzymes. Two-component signal transduction systems such as those mediated by histidine kinase are integral parts of bacterial cellular regulatory processes, and are used to regulate the expression of genes involved in virulence. Members of this family oft...

[ "GO:0000155", "GO:0000160", "GO:0016020" ]

[ "phosphorelay sensor kinase activity", "phosphorelay signal transduction system", "membrane" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PFAM" ]

[ "PF06580" ]

[ "His_kinase" ]

[ 70678 ]

1

[ "EC" ]

[ "2.7.13.3" ]

[ "EC:2.7.13.3" ]

1

[ "6swj", "6swk" ]

2

[ "PUB00000966", "PUB00007866", "PUB00010651", "PUB00011096", "PUB00013246", "PUB00013247", "PUB00013562", "PUB00013563", "PUB00020801", "PUB00042804", "PUB00042805", "PUB00042806", "PUB00042807" ]

[ "9989504", "11406410", "12372152", "10966457", "8868347", "10426948", "8029829", "1482126", "11145881", "16176121", "18076326", "11934609", "11489844" ]

[ "Structure of CheA, a signal-transducing histidine kinase.", "Histidine kinases and response regulator proteins in two-component signaling systems.", "Histidine protein kinases: key signal transducers outside the animal kingdom.", "Two-component signal transduction.", "Protein aspartate phosphatases control...

[ 1999, 2001, 2002, 2000, 1996, 1999, 1994, 1992, 2000, 2005, 2007, 2002, 2001 ]

13

[]

0

null

[ "Bacteria", "Caudoviricetes", "Eukaryota", "unclassified sequences" ]

[ 70313, 2, 73, 290 ]

4

[ "Arabidopsis thaliana", "Escherichia coli (strain K12)" ]

[ 4, 2 ]

2

true

Domain

Signal transduction histidine kinase, internal region

Sig_transdc_His_kin_internal

7

IPR010560

10,560

Neogenin, C-terminal

Neogenin_C

Domain

4,426

false

This entry represents the C terminus of eukaryotic neogenin precursor proteins, which contains several potential phosphorylation sites [ ]. Neogenin is a member of the N-CAM family of cell adhesion molecules (and therefore contains multiple copies of and ) and is closely related to the DCC tumour suppressor gene produc...

[ "GO:0016020" ]

[ "membrane" ]

[ "cellular_component" ]

1

[ "PFAM" ]

[ "PF06583" ]

[ "Neogenin_C" ]

[ 4426 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-373752", "R-HSA-376172", "R-HSA-418885", "R-HSA-418886", "R-HSA-418889", "R-HSA-418890", "R-HSA-428542", "R-HSA-525793", "R-MMU-373752", "R-MMU-418885", "R-MMU-418889", "R-RNO-373752", "R-RNO-418885", "R-RNO-418889" ]

[ "REACTOME:R-HSA-373752", "REACTOME:R-HSA-376172", "REACTOME:R-HSA-418885", "REACTOME:R-HSA-418886", "REACTOME:R-HSA-418889", "REACTOME:R-HSA-418890", "REACTOME:R-HSA-428542", "REACTOME:R-HSA-525793", "REACTOME:R-MMU-373752", "REACTOME:R-MMU-418885", "REACTOME:R-MMU-418889", "REACTOME:R-RNO-373...

14

[ "3au4", "3o71", "3pzd", "6bz3" ]

4

[ "PUB00012749", "PUB00012750" ]

[ "9121761", "9264410" ]

[ "Identification and characterization of neogenin, a DCC-related gene.", "Mouse Neogenin, a DCC-like molecule, has four splice variants and is expressed widely in the adult mouse and during embryogenesis." ]

[ 1997, 1997 ]

2

[]

0

null

[ "Eukaryota" ]

[ 4426 ]

1

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 77, 6, 4, 5, 12 ]

5

true

Domain

Neogenin, C-terminal

Neogenin_C

5

IPR010561

10,561

Protein LIN-9/Protein ALWAYS EARLY

LIN-9/ALY1

Family

5,200

false

This entry represents protein LIN-9/ALWAYS EARLY (LIN-9/ALY). LIN-9 from Caenorhabditis elegans is a homologue of the Drosophila always early (ALY) protein, which functions as a repressor of cell cycle regulated genes [ , ]. LIN-9 is a component of the evolutionary conserved DREAM (MuvB/DRM) complex, which represses tr...

[ "GO:0006351", "GO:0017053" ]

[ "DNA-templated transcription", "transcription repressor complex" ]

[ "biological_process", "cellular_component" ]

2

[ "PANTHER" ]

[ "PTHR21689" ]

[ "" ]

[ 5200 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-CEL-1538133", "R-DRE-1538133", "R-HSA-1362277", "R-HSA-1362300", "R-HSA-1538133", "R-HSA-156711", "R-HSA-69202", "R-HSA-69205", "R-HSA-69656", "R-MMU-1538133" ]

[ "REACTOME:R-CEL-1538133", "REACTOME:R-DRE-1538133", "REACTOME:R-HSA-1362277", "REACTOME:R-HSA-1362300", "REACTOME:R-HSA-1538133", "REACTOME:R-HSA-156711", "REACTOME:R-HSA-69202", "REACTOME:R-HSA-69205", "REACTOME:R-HSA-69656", "REACTOME:R-MMU-1538133" ]

10

[ "6c48", "7n40", "7r1d" ]

3

[ "PUB00067939", "PUB00067941", "PUB00067942", "PUB00067943", "PUB00067944", "PUB00067950" ]

[ "17075059", "15538385", "16730350", "1524653", "15246533", "23667535" ]

[ "Some C. elegans class B synthetic multivulva proteins encode a conserved LIN-35 Rb-containing complex distinct from a NuRD-like complex.", "Inhibition of oncogenic transformation by mammalian Lin-9, a pRB-associated protein.", "A mutant allele of BARA/LIN-9 rescues the cdk4-/- phenotype by releasing the repres...

[ 2006, 2004, 2006, 1992, 2004, 2013 ]

6

[]

0

null

[ "Eukaryota" ]

[ 5200 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 16, 1, 1, 24, 7, 5, 10, 5, 56 ]

9

true

Family

Protein LIN-9/Protein ALWAYS EARLY

LIN-9/ALY1

9

IPR010563

10,563

TraK, N-terminal

TraK_N

Domain

1,686

false

This entry represents the N-terminal domain observed in several TraK proteins from Escherichia coli and related proteins. TraK is known to be essential for pilus assembly but its exact role in this process is unknown [ ].

[]

0

[ "PFAM" ]

[ "PF06586" ]

[ "TraK_N" ]

[ 1686 ]

1

[ "GP" ]

[ "GenProp0485" ]

[ "GP:GenProp0485" ]

1

[ "7oko", "7spb", "7spi" ]

3

[ "PUB00012609" ]

[ "8655498" ]

[ "Analysis of the traLEKBP sequence and the TraP protein from three F-like plasmids: F, R100-1 and ColB2." ]

[ 1996 ]

1

[]

0

null

[ "Opisthokonta", "Pseudomonadati", "metagenomes" ]

[ 4, 1673, 9 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Domain

TraK, N-terminal

TraK_N

7

IPR010564

10,564

Protein of unknown function DUF1137

DUF1137

Family

31

false

This family consists of several hypothetical proteins specific to Chlamydia species. The function of this family is unknown.

[]

0

[ "PFAM" ]

[ "PF06587" ]

[ "DUF1137" ]

[ 31 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Chlamydia" ]

[ 31 ]

1

[]

0

true

Family

Protein of unknown function DUF1137

DUF1137

5

IPR010565

10,565

Muskelin, N-terminal

Muskelin_N

Domain

2,386

false

This entry represents the N-terminal region of muskelin and is found in conjunction with several repeats. Muskelin is an intracellular, kelch repeat protein that is needed in cell-spreading responses to the matrix adhesion molecule, thrombospondin-1 [ ].

[]

0

[ "PFAM" ]

[ "PF06588" ]

[ "Muskelin_N" ]

[ 2386 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-9861718", "R-MMU-9861718", "R-RNO-9861718", "R-SPO-9861718" ]

[ "REACTOME:R-HSA-9861718", "REACTOME:R-MMU-9861718", "REACTOME:R-RNO-9861718", "REACTOME:R-SPO-9861718" ]

4

[ "4oyu", "4pqq", "8ttq" ]

3

[ "PUB00011841" ]

[ "12384287" ]

[ "Characterization of a Drosophila melanogaster orthologue of muskelin." ]

[ 2002 ]

1

[]

0

null

[ "Eukaryota" ]

[ 2386 ]

1

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 2, 4, 7, 2, 7, 1 ]

6

true

Domain

Muskelin, N-terminal

Muskelin_N

3

IPR010566

10,566

Haemolysin-type calcium binding-related

Haemolys_ca-bd

Domain

2,140

false

This family consists of a number of bacteria specific domains, which are found in haemolysin-type calcium binding proteins. This family is found in conjunction with and is often found in multiple copies.

[]

0

[ "PFAM" ]

[ "PF06594" ]

[ "HCBP_related" ]

[ 2140 ]

1

[]

0

[ "5cvw", "5cxl", "6sus", "7rah", "7usl" ]

5

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 2128, 3, 9 ]

3

[]

0

true

Domain

Haemolysin-type calcium binding-related

Haemolys_ca-bd

3

IPR010567

10,567

Protein OrfX2/OrfX3/P47

OrfX2/OrfX3/P47

Domain

352

false

This family consists of several proteins (P47 and OrfX cluster) from various Clostridium species [ ] as well as related sequences from other bacteria. P47 and OrfX cluster proteins adopt a complex fold which has an internal structural duplication. They share structural similarity to lipopolysaccharide binding protein (...

[]

0

[ "PFAM" ]

[ "PF06597" ]

[ "OrfX-like" ]

[ 352 ]

1

[]

0

[ "5wix", "6ekt", "6ekv", "8bgm", "8fbd", "8fbf", "9arj", "9ark", "9arl" ]

9

[ "PUB00019318", "PUB00103915" ]

[ "9767710", "29067689" ]

[ "Characterization of the genes encoding the botulinum neurotoxin complex in a strain of Clostridium botulinum producing type B and F neurotoxins.", "Crystal structures of OrfX2 and P47 from a Botulinum neurotoxin OrfX-type gene cluster." ]

[ 1998, 2017 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "Methanococcus maripaludis" ]

[ 324, 25, 3 ]

3

[]

0

true

Domain

Protein OrfX2/OrfX3/P47

OrfX2/OrfX3/P47

4

IPR010568

10,568

Chlorovirus glycoprotein repeat

Chlorovirusi_glycop_rpt

Repeat

47

false

This entry contains a number of repeats found in Chlorovirus glycoproteins. The function of these proteins is unknown.

[]

0

[ "PFAM" ]

[ "PF06598" ]

[ "Chlorovi_GP_rpt" ]

[ 47 ]

1

[]

0

[ "8h2i" ]

1

[]

0

[]

0

null

[ "Chlorovirus" ]

[ 47 ]

1

[]

0

true

Repeat

Chlorovirus glycoprotein repeat

Chlorovirusi_glycop_rpt

4

IPR010569

10,569

Myotubularin-like, phosphatase domain

Myotubularin-like_Pase_dom

Domain

32,580

false

This entry represents the phosphatase domain within eukaryotic myotubularin-related proteins. Myotubularin is a dual-specific lipid phosphatase that dephosphorylates phosphatidylinositol 3-phosphate and phosphatidylinositol (3,5)-bi-phosphate [ ]. Mutations in gene encoding myotubularin-related proteins have been assoc...

[]

0

[ "PFAM", "PROFILE" ]

[ "PF06602", "PS51339" ]

[ "Myotub-related", "PPASE_MYOTUBULARIN" ]

[ 32010, 32289 ]

2

[ "EC", "GP", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACT...

[ "3.1.3", "GenProp1511", "R-BTA-1483248", "R-BTA-1660499", "R-BTA-1660516", "R-BTA-1660517", "R-CEL-1483248", "R-CEL-1660499", "R-CEL-1660516", "R-CEL-1660517", "R-CEL-8876198", "R-CEL-9035034", "R-DDI-1483248", "R-DDI-1632852", "R-DDI-1660499", "R-DDI-1660516", "R-DDI-1660517", "R-...

[ "EC:3.1.3", "GP:GenProp1511", "REACTOME:R-BTA-1483248", "REACTOME:R-BTA-1660499", "REACTOME:R-BTA-1660516", "REACTOME:R-BTA-1660517", "REACTOME:R-CEL-1483248", "REACTOME:R-CEL-1660499", "REACTOME:R-CEL-1660516", "REACTOME:R-CEL-1660517", "REACTOME:R-CEL-8876198", "REACTOME:R-CEL-9035034", "R...

58

[ "1lw3", "1m7r", "1zsq", "1zvr", "2yf0", "4y7i", "5c16", "5gnh" ]

8

[ "PUB00012753", "PUB00012754", "PUB00022130", "PUB00035793", "PUB00043723", "PUB00073211", "PUB00095340", "PUB00099883" ]

[ "12847286", "12045210", "14690594", "9818190", "16828287", "16787938", "26143924", "25264170" ]

[ "Identification of myotubularin as the lipid phosphatase catalytic subunit associated with the 3-phosphatase adapter protein, 3-PAP.", "Loss of phosphatase activity in myotubularin-related protein 2 is associated with Charcot-Marie-Tooth disease type 4B1.", "Crystal structure of a phosphoinositide phosphatase, ...

[ 2003, 2002, 2003, 1998, 2006, 2006, 2015, 2015 ]

8

[]

[ "IPR030572", "IPR030587", "IPR030590", "IPR030591", "IPR046352" ]

0

5

0

[ "Bacteria", "Eukaryota", "freshwater metagenome" ]

[ 9, 32570, 1 ]

3

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 7, 8, 87, 18, 93, 51, 2, 4, 63, 1, 1, 11 ]

12

true

Domain

Myotubularin-like, phosphatase domain

Myotubularin-like_Pase_dom

3

IPR010570

10,570

UpxZ family

UpxZ_fam

Family

713

false

The UpxZ family of proteins acts to inhibit transcription of heterologous capsular polysaccharide loci in Bacteroides species by interfering with the action of the UpxY family of transcription anti-terminators. As antagonists of polysaccharide locus-specific UpxY transcription anti-terminators, the UpxZ proteins exert ...

[]

0

[ "PFAM" ]

[ "PF06603" ]

[ "UpxZ" ]

[ 713 ]

1

[]

0

[ "4epz" ]

1

[ "PUB00062144" ]

[ "20547868" ]

[ "Trans locus inhibitors limit concomitant polysaccharide synthesis in the human gut symbiont Bacteroides fragilis." ]

[ 2010 ]

1

[]

0

null

[ "Myoviridae sp. ctTrm2", "Pseudomonadati", "termite gut metagenome" ]

[ 1, 701, 11 ]

3

[]

0

true

Family

UpxZ family

UpxZ_fam

5

IPR010571

10,571

Outer membrane lipoprotein, Omp19, bacterial

OM_lipoprot_Omp19_bac

Family

635

false

This entry represents the bacterial outer membrane lipoprotein omp19 [ ]. Its function is not clear.

[ "GO:0019867" ]

[ "outer membrane" ]

[ "cellular_component" ]

1

[ "PIRSF" ]

[ "PIRSF034005" ]

[ "OM_lipoprot_Omp19_bac" ]

[ 635 ]

1

[]

0

[]

0

[ "PUB00012755" ]

[ "10456959" ]

[ "Outer membrane proteins Omp10, Omp16, and Omp19 of Brucella spp. are lipoproteins." ]

[ 1999 ]

1

[]

0

null

[ "Alphaproteobacteria", "marine sediment metagenome" ]

[ 634, 1 ]

2

[]

0

true

Family

Outer membrane lipoprotein, Omp19, bacterial

OM_lipoprot_Omp19_bac

1

IPR010572

10,572

Tail spike domain

Tail_dom

Domain

4,525

false

This is a domain found in a family of prophage tail proteins, including the gp59 tail-assossiated lysin protein from Staphylococcus aureus bacteriophage where it comprises the tip of the tail [ ] . Many members of this group are predicted to be endopeptidases.

[]

0

[ "PFAM" ]

[ "PF06605" ]

[ "Prophage_tail" ]

[ 4525 ]

1

[]

0

[ "3gs9", "6v8i", "9j1k" ]

3

[ "PUB00151022", "PUB00156034" ]

[ "22171743", "32069326" ]

[ "Role of bacteriophage SPP1 tail spike protein gp21 on host cell receptor binding and trigger of phage DNA ejection.", "Structure of the host cell recognition and penetration machinery of a Staphylococcus aureus bacteriophage." ]

[ 2012, 2020 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "Methanobacteriota", "Viruses", "unclassified sequences" ]

[ 3778, 5, 2, 718, 22 ]

5

[]

0

true

Domain

Tail spike domain

Tail_dom

6

IPR010573

10,573

Major facilitator transporter Str1/Tri12-like

MFS_Str1/Tri12-like

Family

5,618

false

This entry represents a group of major facilitator transporters mostly from fungi, including Str1 from Schizosaccharomyces pombe and Tri12 from Fusarium sporotrichioides. Str1 is involved in the transport of siderophore iron and has a role in iron homeostasis [ ]. Tri12 is a trichothecene efflux pump that may play a ro...

[ "GO:0022857", "GO:0055085" ]

[ "transmembrane transporter activity", "transmembrane transport" ]

[ "molecular_function", "biological_process" ]

2

[ "PFAM" ]

[ "PF06609" ]

[ "TRI12" ]

[ 5618 ]

1

[]

0

[]

0

[ "PUB00012757", "PUB00078889" ]

[ "10485289", "12888492" ]

[ "TRI12, a trichothecene efflux pump from Fusarium sporotrichioides: gene isolation and expression in yeast.", "Fep1 represses expression of the fission yeast Schizosaccharomyces pombe siderophore-iron transport system." ]

[ 1999, 2003 ]

2

[]

[ "IPR053791" ]

0

1

0

[ "Bacteria", "Candidatus Methanomassiliicoccus intestinalis", "Eukaryota", "mine drainage metagenome" ]

[ 18, 1, 5597, 2 ]

4

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 1 ]

2

true

Family

Major facilitator transporter Str1/Tri12-like

MFS_Str1/Tri12-like

7

IPR010574

10,574

L-alanine exporter AlaE

Ala_export_AlaE

Family

1,403

false

AlaE is an inducible L-alanine exporter [ ].

[ "GO:0034639", "GO:0016020" ]

[ "L-amino acid efflux transmembrane transporter activity", "membrane" ]

[ "molecular_function", "cellular_component" ]

2

[ "HAMAP", "PFAM" ]

[ "MF_00914", "PF06610" ]

[ "L_Ala_exporter", "AlaE" ]

[ 1239, 1403 ]

2

[]

0

[]

0

[ "PUB00060685" ]

[ "21531828" ]

[ "Inducible L-alanine exporter encoded by the novel gene ygaW (alaE) in Escherichia coli." ]

[ 2011 ]

1

[]

0

null

[ "Bacteria", "Elysia marginata", "Thermoproteati", "metagenomes" ]

[ 1397, 1, 2, 3 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

L-alanine exporter AlaE

Ala_export_AlaE

3

IPR010575

10,575

KorB, C-terminal

KorB_C

Domain

281

false

This domain is found in several KorB transcriptional repressor proteins. The korB gene is a major regulatory element in the replication and maintenance of broad host-range plasmid RK2. It negatively controls the replication gene trfA, the host-lethal determinants kilA and kilB, and the korA-korB operon [ ]. This family...

[ "GO:0003677", "GO:0045892" ]

[ "DNA binding", "negative regulation of DNA-templated transcription" ]

[ "molecular_function", "biological_process" ]

2

[ "PFAM" ]

[ "PF06613" ]

[ "KorB_C" ]

[ 281 ]

1

[]

0

[ "1igq", "1igu" ]

2

[ "PUB00012758" ]

[ "3430606" ]

[ "Nucleotide sequence of korB, a replication control gene of broad host-range plasmid RK2." ]

[ 1987 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "plasmids" ]

[ 270, 3, 8 ]

3

[]

0

true

Domain

KorB, C-terminal

KorB_C

5

IPR010578

10,578

Single-minded, C-terminal

SIM_C

Domain

1,835

false

In Drosophila, single-minded (sim) is a transcription factor that acts as the master regulator of neurogenesis. Two mammalian homologues of Sim which have been identified, Sim1 and Sim2, are novel heterodimerisation partners for ARNT in vitro, and may function both as positive and negative transcriptional regulators in...

[ "GO:0003677", "GO:0003700", "GO:0006355" ]

[ "DNA binding", "DNA-binding transcription factor activity", "regulation of DNA-templated transcription" ]

[ "molecular_function", "molecular_function", "biological_process" ]

3

[ "PFAM", "PROFILE" ]

[ "PF06621", "PS51302" ]

[ "SIM_C", "SIM_C" ]

[ 1820, 1746 ]

2

[]

0

[]

0

[ "PUB00000420", "PUB00005472", "PUB00006196", "PUB00012762", "PUB00012763", "PUB00043752", "PUB00043753" ]

[ "7756254", "9301332", "9382818", "9020169", "9199934", "11091086", "16484282" ]

[ "1.4 A structure of photoactive yellow protein, a cytosolic photoreceptor: unusual fold, active site, and chromophore.", "PAS domain S-boxes in Archaea, Bacteria and sensors for oxygen and redox.", "PAS: a multifunctional domain family comes to light.", "Two murine homologs of the Drosophila single-minded pro...

[ 1995, 1997, 1997, 1997, 1997, 2000, 2006 ]

7

[]

0

null

[ "Bacteria", "Vertebrata" ]

[ 6, 1829 ]

2

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 9, 3, 4, 4 ]

4

true

Domain

Single-minded, C-terminal

SIM_C

5

IPR010579

10,579

MHC class I, alpha chain, C-terminal

MHC_I_a_C

Domain

14,043

false

This entry represents the C-terminal cytoplasmic tail domain found in MHC class I, alpha chain sequences from mammals. Major Histocompatibility Complex (MHC) glycoproteins are heterodimeric cell surface receptors that function to present antigen peptide fragments to T cells responsible for cell-mediated immune response...

[ "GO:0006955", "GO:0019882" ]

[ "immune response", "antigen processing and presentation" ]

[ "biological_process", "biological_process" ]

2

[ "PFAM" ]

[ "PF06623" ]

[ "MHC_I_C" ]

[ 14043 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-1236974", "R-HSA-1236977", "R-HSA-164940", "R-HSA-198933", "R-HSA-2172127", "R-HSA-2424491", "R-HSA-6798695", "R-HSA-877300", "R-HSA-8866654", "R-HSA-909733", "R-HSA-9705671", "R-HSA-983170", "R-MMU-1236974", "R-MMU-1236977", "R-MMU-198933", "R-MMU-2172127", "R-MMU-6798695", ...

[ "REACTOME:R-HSA-1236974", "REACTOME:R-HSA-1236977", "REACTOME:R-HSA-164940", "REACTOME:R-HSA-198933", "REACTOME:R-HSA-2172127", "REACTOME:R-HSA-2424491", "REACTOME:R-HSA-6798695", "REACTOME:R-HSA-877300", "REACTOME:R-HSA-8866654", "REACTOME:R-HSA-909733", "REACTOME:R-HSA-9705671", "REACTOME:R-...

18

[ "1bii", "1s7q", "1s7r", "1s7s", "1s7t", "1s7u", "1s7v", "1s7w", "1s7x", "4emz", "4en2", "6at5", "6avf", "6avg", "6eny", "6gb5", "6gb7", "6h6d", "6h6h", "7edo", "7jwi", "7jwj", "7qpd", "7rtd", "7rtr", "7tlt", "7u1r", "7um2", "7ur1", "7ux3", "8d4c", "8d4d"...

49

[ "PUB00007109", "PUB00016272" ]

[ "9485452", "15526153" ]

[ "Fast association rates suggest a conformational change in the MHC class I molecule H-2Db upon peptide binding.", "Evolutionary and functional perspectives of the major histocompatibility complex class I antigen-processing machinery." ]

[ 1998, 2004 ]

2

[]

0

null

[ "Bilateria", "Curtobacterium citri" ]

[ 14042, 1 ]

2

[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 6042, 62, 93 ]

3

true

Domain

MHC class I, alpha chain, C-terminal

MHC_I_a_C

4

IPR010580

10,580

Stress-associated endoplasmic reticulum protein

ER_stress-assoc

Family

4,071

false

This entry contains Serp1/Serp2 and yeast Ysy6 stress-associated endoplasmic reticulum proteins. In humans, Serp1 (also known as RAMP4) interacts with target proteins during their translocation into the lumen of the endoplasmic reticulum. It has also been shown to protect unfolded target proteins against degradation du...

[ "GO:0005783" ]

[ "endoplasmic reticulum" ]

[ "cellular_component" ]

1

[ "PFAM", "PANTHER" ]

[ "PF06624", "PTHR15601" ]

[ "RAMP4", "" ]

[ 4071, 2761 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-9609523", "R-DDI-9609523", "R-HSA-381038", "R-HSA-9609523", "R-MMU-9609523", "R-RNO-9609523", "R-SCE-9609523" ]

[ "REACTOME:R-BTA-9609523", "REACTOME:R-DDI-9609523", "REACTOME:R-HSA-381038", "REACTOME:R-HSA-9609523", "REACTOME:R-MMU-9609523", "REACTOME:R-RNO-9609523", "REACTOME:R-SCE-9609523" ]

7

[ "8rjb", "8rjc", "8rjd" ]

3

[ "PUB00012764", "PUB00053970" ]

[ "10601334", "10469658" ]

[ "Stress-associated endoplasmic reticulum protein 1 (SERP1)/Ribosome-associated membrane protein 4 (RAMP4) stabilizes membrane proteins during stress and facilitates subsequent glycosylation.", "Control of glycosylation of MHC class II-associated invariant chain by translocon-associated RAMP4." ]

[ 1999, 1999 ]

2

[]

0

null

[ "Eukaryota", "Nakamurella sp. A5-74", "bird metagenome" ]

[ 4069, 1, 1 ]

3

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 5, 2, 4, 1, 6, 5, 1, 10, 7, 1, 1, 15 ]

12

true

Family

Stress-associated endoplasmic reticulum protein

ER_stress-assoc

5

IPR010581

10,581

Protein of unknown function DUF1152

DUF1152

Family

1,111

false

This family consists of proteins of unknown function.

[]

0

[ "PFAM", "PIRSF" ]

[ "PF06626", "PIRSF029122" ]

[ "DUF1152", "DUF1152" ]

[ 1111, 55 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Klosneuvirinae", "ecological metagenomes" ]

[ 116, 933, 56, 4, 2 ]

5

[]

0

true

Family

Protein of unknown function DUF1152

DUF1152

8

IPR010582

10,582

Catalase immune-responsive domain

Catalase_immune_responsive

Domain

35,857

false

Catalases ( ) are antioxidant enzymes that catalyse the conversion of hydrogen peroxide to water and molecular oxygen, serving to protect cells from its toxic effects [ ]. Hydrogen peroxide is produced as a consequence of oxidative cellular metabolism and can be converted to the highly reactive hydroxyl radical via tra...

[]

0

[ "PFAM" ]

[ "PF06628" ]

[ "Catalase-rel" ]

[ 35857 ]

1

[ "EC", "GP", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACT...

[ "1.11.1.6", "GenProp1379", "R-BTA-3299685", "R-BTA-6798695", "R-BTA-9033241", "R-CFA-3299685", "R-CFA-6798695", "R-CFA-9033241", "R-DDI-3299685", "R-DDI-6798695", "R-DDI-9033241", "R-DME-3299685", "R-DME-6798695", "R-DME-9033241", "R-DRE-3299685", "R-DRE-6798695", "R-HSA-3299685", ...

[ "EC:1.11.1.6", "GP:GenProp1379", "REACTOME:R-BTA-3299685", "REACTOME:R-BTA-6798695", "REACTOME:R-BTA-9033241", "REACTOME:R-CFA-3299685", "REACTOME:R-CFA-6798695", "REACTOME:R-CFA-9033241", "REACTOME:R-DDI-3299685", "REACTOME:R-DDI-6798695", "REACTOME:R-DDI-9033241", "REACTOME:R-DME-3299685", ...

33

[ "1a4e", "1cf9", "1dgb", "1dgf", "1dgg", "1dgh", "1e93", "1f4j", "1gg9", "1gge", "1ggf", "1ggh", "1ggj", "1ggk", "1gwe", "1gwf", "1gwh", "1h6n", "1h7k", "1hbz", "1iph", "1m7s", "1m85", "1mqf", "1nm0", "1p7y", "1p7z", "1p80", "1p81", "1qf7", "1qqw", "1qwl"...

158

[ "PUB00012765", "PUB00015054", "PUB00044744" ]

[ "11351128", "14745498", "15585332" ]

[ "Mitochondrial catalase and oxidative injury.", "Diversity of structures and properties among catalases.", "Do Th1 or Th2 sequence motifs exist in proteins? Identification of amphipatic immunomodulatory domains in Helicobacter pylori catalase." ]

[ 2001, 2004, 2005 ]

3

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Tupanvirus", "unclassified sequences" ]

[ 164, 24553, 11034, 4, 102 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus",...

[ 22, 4, 2, 6, 1, 4, 7, 3, 6, 2, 2, 1, 14 ]

13

true

Domain

Catalase immune-responsive domain

Catalase_immune_responsive

4

IPR010586

10,586

Type 3 secretion system stator protein

T3SS_stator_protein

Family

527

false

This family consists of type III secretion system (T3SS) stator protein, previously known as nodulation protein NolV, from different Rhizobium species [ ]. The function of this family is unclear, however, it has been suggested that T3SS stator protein is a component of the T3SS, which is used to inject bacterial effect...

[]

0

[ "PFAM" ]

[ "PF06635" ]

[ "T3SS_SCTL" ]

[ 527 ]

1

[]

0

[]

0

[ "PUB00012767" ]

[ "8412662" ]

[ "Molecular cloning and characterization of a sym plasmid locus that regulates cultivar-specific nodulation of soybean by Rhizobium fredii USDA257." ]

[ 1993 ]

1

[ "IPR012842" ]

[]

1

0

1

[ "Bacteria", "invertebrate metagenome" ]

[ 526, 1 ]

2

[]

0

true

Family

Type 3 secretion system stator protein

T3SS_stator_protein

8

IPR010587

10,587

Melanoplus sanguinipes entomopoxvirus (MsEPV), Orf214

MsEPV_Orf214

Family

11

false

This entry is represented by a family of Orfs from Melanoplus sanguinipes entomopoxvirus (MsEPV), these include:Orf214, Orf215, Orf216, Orf217 and Orf62; they are a family of uncharacterised viral proteins.

[]

0

[ "PFAM" ]

[ "PF06636" ]

[ "DUF1157" ]

[ 11 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Melanoplus sanguinipes entomopoxvirus", "Paenibacillus" ]

[ 5, 6 ]

2

[]

0

true

Family

Melanoplus sanguinipes entomopoxvirus (MsEPV), Orf214

MsEPV_Orf214

4

IPR010588

10,588

Myb-related protein P/transcription factor Y1, C-terminal

Myb-rel_proteinP/Y1_C

Domain

142

false

This entry represents the C terminus of plant P/Y1 proteins. Members of this entry are transcriptional regulators of genes encoding enzymes for flavonoid biosynthesis [ , ]. P protein plays a role in the pathway leading to the production of a red phlobaphene pigment [ ], and P proteins are homologous to the DNA-binding...

[]

0

[ "PFAM" ]

[ "PF06640" ]

[ "P_C" ]

[ 142 ]

1

[]

0

[]

0

[ "PUB00012771", "PUB00012772", "PUB00101377", "PUB00101378" ]

[ "8768374", "8313474", "30911880", "25647576" ]

[ "Alleles of the maize P gene with distinct tissue specificities encode Myb-homologous proteins with C-terminal replacements.", "The myb-homologous P gene controls phlobaphene pigmentation in maize floral organs by directly activating a flavonoid biosynthetic gene subset.", "Sorghum 3-Deoxyanthocyanidin Flavonoi...

[ 1996, 1994, 2019, 2015 ]

4

[]

0

null

[ "commelinids" ]

[ 142 ]

1

[ "Oryza sativa subsp. japonica", "Zea mays" ]

[ 2, 22 ]

2

true

Domain

Myb-related protein P/transcription factor Y1, C-terminal

Myb-rel_proteinP/Y1_C

7

IPR010590

10,590

Protein of unknown function DUF1158

DUF1158

Family

809

false

This family consists of several enterobacterial YbdJ proteins. The function of this family is unknown

[]

0

[ "PFAM" ]

[ "PF06643" ]

[ "DUF1158" ]

[ 809 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "metagenomes" ]

[ 806, 3 ]

2

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Protein of unknown function DUF1158

DUF1158

8

IPR010591

10,591

ATP11

Family

4,340

false

This family consists of several eukaryotic ATP11 proteins. The expression of functional F1-ATPase requires two proteins which are encoded by the ATP11 and ATP12 genes [ ]. Atp11p is a molecular chaperone of the mitochondrial matrix that participates in the biogenesis pathway to form F1, which is the catalytic unit of A...

[ "GO:0065003", "GO:0005739" ]

[ "protein-containing complex assembly", "mitochondrion" ]

[ "biological_process", "cellular_component" ]

2

[ "PFAM", "PANTHER" ]

[ "PF06644", "PTHR13126" ]

[ "ATP11", "" ]

[ 4318, 4231 ]

2

[]

0

[ "2p4f" ]

1

[ "PUB00012774", "PUB00019177" ]

[ "1532796", "12829692" ]

[ "Characterization of ATP11 and detection of the encoded protein in mitochondria of Saccharomyces cerevisiae.", "A purified subfragment of yeast Atp11p retains full molecular chaperone activity." ]

[ 1992, 2003 ]

2

[]

0

null

[ "Eukaryota" ]

[ 4340 ]

1

[ "Arabidopsis thaliana", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "...

[ 5, 2, 3, 8, 7, 1, 4, 3, 1, 1, 5 ]

11

true

Family

ATP11

5