LiteFold/InterPro · Datasets at Hugging Face

IPR011284

11,284

3-oxoacyl-(acyl-carrier-protein) reductase

3oxo_ACP_reduc

Family

21,553

false

This entry represents 3-oxoacyl-[ACP] reductase, also called 3-ketoacyl-acyl carrier protein reductase, an enzyme of fatty acid biosynthesis found in many plant and bacterial species. This enzyme is involved in type II fatty acid biosynthesis, where the individual metabolic transformations are carried out by different ...

[ "GO:0004316", "GO:0051287", "GO:0006633" ]

[ "3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity", "NAD binding", "fatty acid biosynthetic process" ]

[ "molecular_function", "molecular_function", "biological_process" ]

3

[ "NCBIFAM" ]

[ "TIGR01830" ]

[ "3oxo_ACP_reduc" ]

[ 21553 ]

1

[ "EC", "GP", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC" ]

[ "1.1.1.100", "GenProp0681", "PWY-5367", "PWY-5971", "PWY-5973", "PWY-5989", "PWY-6282", "PWY-6519", "PWY-7388", "PWY-7663", "PWY-7664", "PWY-7858", "PWY-8173", "PWY-8174", "PWY-8175", "PWY-8203", "PWY-8279", "PWY-8280", "PWY-8427", "PWYG-321" ]

[ "EC:1.1.1.100", "GP:GenProp0681", "METACYC:PWY-5367", "METACYC:PWY-5971", "METACYC:PWY-5973", "METACYC:PWY-5989", "METACYC:PWY-6282", "METACYC:PWY-6519", "METACYC:PWY-7388", "METACYC:PWY-7663", "METACYC:PWY-7664", "METACYC:PWY-7858", "METACYC:PWY-8173", "METACYC:PWY-8174", "METACYC:PWY-8...

20

[ "1edo", "1i01", "1q7b", "1q7c", "2c07", "2cdh", "2hq1", "2nm0", "2p68", "2ph3", "2pnf", "2uvd", "3emk", "3enn", "3f9i", "3ftp", "3grp", "3lyl", "3op4", "3osu", "3rro", "3rsh", "3sj7", "3tzc", "3tzh", "3tzk", "3u09", "3woh", "4afn", "4ag3", "4bnt", "4bnu"...

76

[ "PUB00025859", "PUB00028039", "PUB00028040", "PUB00083882" ]

[ "11669613", "11544358", "16225460", "26975437" ]

[ "Structure of beta-ketoacyl-[acyl carrier protein] reductase from Escherichia coli: negative cooperativity and its structural basis.", "Bacterial fatty acid biosynthesis: targets for antibacterial drug discovery.", "Kinetic, inhibition and structural studies on 3-oxoacyl-ACP reductase from Plasmodium falciparum...

[ 2001, 2001, 2006, 2016 ]

4

[ "IPR002347" ]

[]

1

0

1

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 48, 20108, 1145, 252 ]

4

[ "Arabidopsis thaliana", "Escherichia coli (strain K12)", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 4, 1, 6, 15 ]

4

true

Family

3-oxoacyl-(acyl-carrier-protein) reductase

3oxo_ACP_reduc

5

IPR011285

11,285

3-oxoacyl-(acyl-carrier-protein) reductase, putative

FabG-rel

Family

2,548

false

This entry represents a small, very well conserved family of proteins closely related to the FabG family, , and possibly equal in function. In all completed genomes with a member of this family, a FabG in is also found.

[]

0

[ "NCBIFAM" ]

[ "TIGR01831" ]

[ "fabG_rel" ]

[ 2548 ]

1

[]

0

[ "4iiu", "4iiv", "6nrp", "7caw", "7cax", "7czc" ]

6

[]

0

[ "IPR002347" ]

[]

1

0

1

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 2531, 6, 11 ]

3

[]

0

true

Family

3-oxoacyl-(acyl-carrier-protein) reductase, putative

FabG-rel

3

IPR011286

11,286

2-dehydro-3-deoxy-D-gluconate 5-dehydrogenase

2-deoxy-D-gluc_3_DH

Family

4,624

false

This entry describes 2-dehydro-3-deoxy-D-gluconate 5-dehydrogenase (also called 2-keto-3-deoxygluconate oxidoreductase), a member of the family of short-chain-alcohol dehydrogenases. This protein from Erwinia chrysanthemi has been characterised as an enzyme of pectin degradation [ ].

[ "GO:0008678", "GO:0051287" ]

[ "2-deoxy-D-gluconate 3-dehydrogenase activity", "NAD binding" ]

[ "molecular_function", "molecular_function" ]

2

[ "NCBIFAM" ]

[ "TIGR01832" ]

[ "kduD" ]

[ 4624 ]

1

[ "EC", "METACYC", "METACYC" ]

[ "1.1.1.127", "PWY-6507", "PWY-7562" ]

[ "EC:1.1.1.127", "METACYC:PWY-6507", "METACYC:PWY-7562" ]

3

[ "4hp8", "4z9y", "4za2" ]

3

[ "PUB00014561" ]

[ "1766386" ]

[ "Analysis of an Erwinia chrysanthemi gene cluster involved in pectin degradation." ]

[ 1991 ]

1

[ "IPR002347" ]

[]

1

0

1

[ "Bacteria", "Eukaryota", "metagenomes", "uncultured marine thaumarchaeote AD1000_14_F02" ]

[ 4608, 6, 9, 1 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

2-dehydro-3-deoxy-D-gluconate 5-dehydrogenase

2-deoxy-D-gluc_3_DH

1

IPR011287

11,287

Poly(R)-hydroxyalkanoic acid synthase, class II

PHA_synth_II

Family

1,447

false

This entry represents the class II subfamily of poly(R)-hydroxyalkanoate synthases, which polymerises hydroxyacyl-CoAs, typically with six to fourteen carbons in the hydroxyacyl backbone into aliphatic esters termed poly(R)-hydroxyalkanoic acids [ ]. These polymers accumulate as carbon and energy storage inclusions in ...

[ "GO:0016746", "GO:0042619" ]

[ "acyltransferase activity", "poly-hydroxybutyrate biosynthetic process" ]

[ "molecular_function", "biological_process" ]

2

[ "NCBIFAM" ]

[ "TIGR01839" ]

[ "PHA_synth_II" ]

[ 1447 ]

1

[ "GP" ]

[ "GenProp0055" ]

[ "GP:GenProp0055" ]

1

[]

0

[ "PUB00013497" ]

[ "11418564" ]

[ "PhaC and PhaR are required for polyhydroxyalkanoic acid synthase activity in Bacillus megaterium." ]

[ 2001 ]

1

[]

0

null

[ "Bacteria", "marine sediment metagenome" ]

[ 1445, 2 ]

2

[]

0

true

Family

Poly(R)-hydroxyalkanoic acid synthase, class II

PHA_synth_II

2

IPR011288

11,288

D-tagatose-bisphosphate aldolase, class II, subunit KbaY/GatY

TagBP_ald_KbaY/GatY

Family

1,656

false

Escherichia coli and other enteric bacteria contain two closely related D-tagatose 1,6-bisphosphate (TagBP)-specific aldolases - KbaYZ (also known as AgaYZ) and GatYZ. Unlike other class II aldolases, which are homodimeric enzymes, KbaYZ and GatYZ are heterodimers, and are comprised of subunits KbaY/GatY and GatY/GatZ....

[ "GO:0008270", "GO:0009025", "GO:0005975" ]

[ "zinc ion binding", "tagatose-bisphosphate aldolase activity", "carbohydrate metabolic process" ]

[ "molecular_function", "molecular_function", "biological_process" ]

3

[ "NCBIFAM" ]

[ "TIGR01858" ]

[ "tag_bisphos_ald" ]

[ 1656 ]

1

[ "EC", "METACYC", "METACYC", "METACYC" ]

[ "4.1.2.40", "PWY-7077", "PWY-7395", "PWY-8324" ]

[ "EC:4.1.2.40", "METACYC:PWY-7077", "METACYC:PWY-7395", "METACYC:PWY-8324" ]

4

[ "1gvf" ]

1

[ "PUB00014683", "PUB00014684" ]

[ "11976750", "8955298" ]

[ "Two class II D-tagatose-bisphosphate aldolases from enteric bacteria.", "Molecular analysis of the gat genes from Escherichia coli and of their roles in galactitol transport and metabolism." ]

[ 2002, 1996 ]

2

[ "IPR000771" ]

[ "IPR023788" ]

1

0

[ "Bacteria", "Trichuris trichiura", "metagenomes" ]

[ 1653, 1, 2 ]

3

[ "Escherichia coli (strain K12)" ]

[ 2 ]

1

true

Family

D-tagatose-bisphosphate aldolase, class II, subunit KbaY/GatY

TagBP_ald_KbaY/GatY

6

IPR011289

11,289

Fructose-1,6-bisphosphate aldolase, class 2

Fruc_bis_ald_class-2

Family

6,271

false

Fructose-1,6-bisphosphate (FBP) aldolases reversibly cleave FBP to two triose phosphates, glycerone phophate and D-glyceraldehyde 3-phosphate. They play a key role in both glycolysis (FBP cleavage) and gluconeogenesis (FBP synthesis). These enzymes can be divide into two classes based on their mode of catalysis. Class ...

[ "GO:0004332", "GO:0008270", "GO:0006096", "GO:0030388" ]

[ "fructose-bisphosphate aldolase activity", "zinc ion binding", "glycolytic process", "fructose 1,6-bisphosphate metabolic process" ]

[ "molecular_function", "molecular_function", "biological_process", "biological_process" ]

4

[ "NCBIFAM" ]

[ "TIGR01859" ]

[ "fruc_bis_ald_" ]

[ 6271 ]

1

[ "EC", "GP", "GP", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC" ]

[ "4.1.2.13", "GenProp0120", "GenProp1286", "PWY-1042", "PWY-1861", "PWY-5484", "PWY-6142", "PWY-7385", "PWY-8178", "PWY-8404" ]

[ "EC:4.1.2.13", "GP:GenProp0120", "GP:GenProp1286", "METACYC:PWY-1042", "METACYC:PWY-1861", "METACYC:PWY-5484", "METACYC:PWY-6142", "METACYC:PWY-7385", "METACYC:PWY-8178", "METACYC:PWY-8404" ]

10

[ "1rv8", "1rvg", "2fjk", "3c4u", "3c52", "3c56", "3gak", "3gay", "3n9r", "3n9s", "3q94", "4to8", "5uck", "5ucn", "5ucp", "5ucs", "5ucz", "5ud0", "5ud1", "5ud2", "5ud3", "5ud4", "5vjf", "7nc7", "7ncc" ]

25

[ "PUB00005383", "PUB00022639" ]

[ "1412694", "14699122" ]

[ "Fructose-bisphosphate aldolases: an evolutionary history.", "Induced fit movements and metal cofactor selectivity of class II aldolases: structure of Thermus aquaticus fructose-1,6-bisphosphate aldolase." ]

[ 1992, 2004 ]

2

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Siphoviridae sp. ctBLh2", "unclassified sequences" ]

[ 4, 6195, 30, 1, 41 ]

5

[]

0

true

Family

Fructose-1,6-bisphosphate aldolase, class 2

Fruc_bis_ald_class-2

2

IPR011290

11,290

Nitrogenase iron-iron protein, alpha chain

Nase_Fe-Fe_asu

Family

152

false

This entry represents the all-iron variant of the nitrogenase component I alpha chain. Molybdenum-iron and vanadium iron forms are also found. The complete complex contains two alpha chains, two beta chains and two delta chains. The component I associates with component II also known as the iron protein which serves to...

[ "GO:0016163", "GO:0051536", "GO:0009399" ]

[ "nitrogenase activity", "iron-sulfur cluster binding", "nitrogen fixation" ]

[ "molecular_function", "molecular_function", "biological_process" ]

3

[ "NCBIFAM" ]

[ "TIGR01861" ]

[ "ANFD" ]

[ 152 ]

1

[ "EC", "GP" ]

[ "1.18.6.1", "GenProp0631" ]

[ "EC:1.18.6.1", "GP:GenProp0631" ]

2

[ "8boq", "8oie", "8pbb" ]

3

[]

0

[ "IPR005974" ]

[]

1

0

1

[ "Bacteria", "Methanobacteriota", "metagenomes" ]

[ 143, 7, 2 ]

3

[]

0

true

Family

Nitrogenase iron-iron protein, alpha chain

Nase_Fe-Fe_asu

5

IPR011291

11,291

Peptidase M20A, peptidase V

Pept_M20A_peptidaseV

Family

967

false

This entry represents a small clade of dipeptidase enzymes from the Lactobacillaceae, which belong to MEROPS peptidase family M20A. The Lactococcus lactis enzyme has been shown to act on a wide range of dipeptides, but not larger peptides [ ]. The enzyme from Lactobacillus delbrueckii was originally characterised as a ...

[]

0

[ "NCBIFAM" ]

[ "TIGR01886" ]

[ "dipeptidase" ]

[ 967 ]

1

[]

0

[ "1lfw" ]

1

[ "PUB00013828", "PUB00079902" ]

[ "12176387", "9171382" ]

[ "Crystal structure of the dinuclear zinc aminopeptidase PepV from Lactobacillus delbrueckii unravels its preference for dipeptides.", "Cloning and analysis of the pepV dipeptidase gene of Lactococcus lactis MG1363." ]

[ 2002, 1997 ]

2

[ "IPR010964" ]

[]

1

0

1

[ "Bacteria" ]

[ 967 ]

1

[]

0

true

Family

Peptidase M20A, peptidase V

Pept_M20A_peptidaseV

2

IPR011292

11,292

Na(+)-translocating NADH-quinone reductase subunit D

NqrD

Family

4,234

false

Na(+)-translocating NADH-quinone reductase (NQR) functions as a primary Na(+) pump in the respiratory chain of Gram-negative marine and halophilic bacteria [ ]. The NQR complex reduces ubiquinone-1 to ubiquinol by two successive reactions, which involve the co-factor FAD. The NQR complex is composed of six subunits, th...

[ "GO:0016655" ]

[ "oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor" ]

[ "molecular_function" ]

1

[ "HAMAP", "NCBIFAM" ]

[ "MF_00428", "TIGR01939" ]

[ "NqrD", "nqrD" ]

[ 4029, 4229 ]

2

[ "EC", "GP" ]

[ "7.2.1.1", "GenProp0129" ]

[ "EC:7.2.1.1", "GP:GenProp0129" ]

2

[ "7xk3", "7xk4", "7xk5", "7xk6", "7xk7", "8a1t", "8a1u", "8a1v", "8a1w", "8a1x", "8a1y", "8acw", "8acy", "8ad0", "8evu", "8ew3", "9lrr", "9u5g", "9ud2", "9ud3", "9ud4", "9ud5", "9ud6", "9ud8", "9ud9", "9uda", "9udf", "9udg", "9uuu" ]

29

[ "PUB00013512" ]

[ "11248187" ]

[ "Recent progress in the Na(+)-translocating NADH-quinone reductase from the marine Vibrio alginolyticus." ]

[ 2001 ]

1

[ "IPR003667" ]

[]

1

0

1

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 4149, 10, 75 ]

3

[]

0

true

Family

Na(+)-translocating NADH-quinone reductase subunit D

NqrD

7

IPR011293

11,293

Ion-translocating oxidoreductase complex, subunit RnfA/RsxA

Ion_transpt_RnfA/RsxA

Family

5,931

false

The six subunit complex RnfABCDGE in Rhodobacter capsulatus (Rhodopseudomonas capsulata) encodes an apparent NADH oxidoreductase responsible for electron transport to nitrogenase, necessary for nitrogen fixation [ , , ]. A closely related complex in Escherichia coli, RsxABCDGE (Reducer of SoxR), reduces the 2Fe-2S-cont...

[ "GO:0022900" ]

[ "electron transport chain" ]

[ "biological_process" ]

1

[ "HAMAP", "NCBIFAM" ]

[ "MF_00459", "TIGR01943" ]

[ "RsxA_RnfA", "rnfA" ]

[ 5742, 5817 ]

2

[ "GP" ]

[ "GenProp0130" ]

[ "GP:GenProp0130" ]

1

[ "7zc6", "8ahx", "8rb8", "8rb9", "8rbm", "8rbq", "9eri", "9erj", "9erk", "9erl" ]

10

[ "PUB00007528", "PUB00013513", "PUB00020279", "PUB00062387" ]

[ "9154934", "12773378", "8264535", "10671439" ]

[ "Membrane localization, topology, and mutual stabilization of the rnfABC gene products in Rhodobacter capsulatus and implications for a new family of energy-coupling NADH oxidoreductases.", "A reducing system of the superoxide sensor SoxR in Escherichia coli.", "Identification of a new class of nitrogen fixatio...

[ 1997, 2003, 1993, 2000 ]

4

[ "IPR003667" ]

[ "IPR049674" ]

1

0

[ "Bacteria", "Eukaryota", "Methanobacteriota", "unclassified sequences" ]

[ 5779, 3, 38, 111 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Ion-translocating oxidoreductase complex, subunit RnfA/RsxA

Ion_transpt_RnfA/RsxA

3

IPR011294

11,294

3-hydroxybutyrate dehydrogenase

3-OHbutyrate_DH

Family

9,958

false

This entry represents a subfamily of the short chain dehydrogenases. Characterised members so far as 3-hydroxybutyrate dehydrogenases and are found in species that accumulate ester polymers called polyhydroxyalkanoic acids (PHAs) under certain conditions. Several members of the family are from species not known to accu...

[ "GO:0003858" ]

[ "3-hydroxybutyrate dehydrogenase activity" ]

[ "molecular_function" ]

1

[ "NCBIFAM" ]

[ "TIGR01963" ]

[ "PHB_DH" ]

[ 9958 ]

1

[ "GP" ]

[ "GenProp0055" ]

[ "GP:GenProp0055" ]

1

[ "1wmb", "1x1t", "2q2q", "2q2v", "2q2w", "2yz7", "2ztl", "2ztm", "2ztu", "2ztv", "3v2h", "3vdq", "3vdr", "3w8d", "3w8e", "3w8f", "4trr", "5b4t", "5b4u", "5b4v", "5yss", "6zzo", "6zzp", "6zzq", "6zzs", "8dt1", "9c5h", "9c5i", "9c5j", "9c5k", "9c5l", "9c5m"...

34

[]

0

[ "IPR002347" ]

[]

1

0

1

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 9807, 108, 43 ]

3

[]

0

true

Family

3-hydroxybutyrate dehydrogenase

3-OHbutyrate_DH

7

IPR011295

11,295

2-polyprenyl-6-methoxyphenol 4-hydroxylase

UbiH

Family

4,236

false

This entry represents the FAD-dependent monooxygenase responsible for the second hydroxylation step in the aerobic ubiquinone biosynthetic pathway [ , , ]. The sequences in this entry are restricted to the proteobacteria. This family is closely related to the UbiF hydroxylase which catalyses the final hydroxylation ste...

[ "GO:0008681", "GO:0006744" ]

[ "2-octaprenyl-6-methoxyphenol hydroxylase activity", "ubiquinone biosynthetic process" ]

[ "molecular_function", "biological_process" ]

2

[ "NCBIFAM" ]

[ "TIGR01984" ]

[ "UbiH" ]

[ 4236 ]

1

[ "GP" ]

[ "GenProp1744" ]

[ "GP:GenProp1744" ]

1

[]

0

[ "PUB00013761", "PUB00013848", "PUB00061715" ]

[ "1339425", "11583838", "4572721" ]

[ "Isolation and characterization of a light-sensitive mutant of Escherichia coli K-12 with a mutation in a gene that is required for the biosynthesis of ubiquinone.", "Ubiquinone biosynthesis in microorganisms.", "Pathway for ubiquinone biosynthesis in Escherichia coli K-12: gene-enzyme relationships and interme...

[ 1992, 2001, 1973 ]

3

[ "IPR010971" ]

[]

1

0

1

[ "Bacteria", "Protostomia", "metagenomes" ]

[ 4200, 9, 27 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

2-polyprenyl-6-methoxyphenol 4-hydroxylase

UbiH

6

IPR011296

11,296

Phosphotransferase system, trehalose-specific IIBC component

PTS_IIBC_treh

Domain

4,020

false

This entry represents the fused enzyme II B and C components of the trehalose-specific PTS sugar transporter system [ ]. Trehalose is converted to trehalose-6-phosphate in the process of translocation into the cell. These transporters lack their own IIA domains and instead use the glucose IIA protein (IIAglc or Crr) [ ...

[ "GO:0015574", "GO:0015771", "GO:0016020" ]

[ "trehalose transmembrane transporter activity", "trehalose transport", "membrane" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "NCBIFAM" ]

[ "TIGR01992" ]

[ "PTS-IIBC-Tre" ]

[ 4020 ]

1

[ "GP", "GP" ]

[ "GenProp0119", "GenProp0271" ]

[ "GP:GenProp0119", "GP:GenProp0271" ]

2

[]

0

[ "PUB00013774", "PUB00013786", "PUB00013790", "PUB00013792", "PUB00013795", "PUB00013799" ]

[ "3023298", "12003938", "11260467", "11553642", "12454482", "12949193" ]

[ "Transport of trehalose in Salmonella typhimurium.", "Redundancy in periplasmic binding protein-dependent transport systems for trehalose, sucrose, and maltose in Sinorhizobium meliloti.", "Sugar transport in Sulfolobus solfataricus is mediated by two families of binding protein-dependent ABC transporters.", ...

[ 1986, 2002, 2001, 2001, 2002, 2003 ]

6

[]

0

null

[ "Bacteria", "Eukaryota", "bioreactor metagenome" ]

[ 4017, 2, 1 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Domain

Phosphotransferase system, trehalose-specific IIBC component

PTS_IIBC_treh

3

IPR011297

11,297

Phosphotransferase system, beta-glucoside-specific IIABC component

PTS_IIABC_b_glu

Family

5,546

false

The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS) [ , ] is a major carbohydrate transport system in bacteria. The PTS catalyses the phosphorylation of incoming sugar substrates and coupled with translocation across the cell membrane, makes the PTS a link between the uptake and metabolism of sugars...

[ "GO:0008982", "GO:0009401", "GO:0005886" ]

[ "protein-N(PI)-phosphohistidine-sugar phosphotransferase activity", "phosphoenolpyruvate-dependent sugar phosphotransferase system", "plasma membrane" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "NCBIFAM" ]

[ "TIGR01995" ]

[ "PTS-II-ABC-beta" ]

[ 5546 ]

1

[ "EC", "GP", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC" ]

[ "2.7.1.-", "GenProp0119", "PWY-5129", "PWY-6322", "PWY-6369", "PWY-6626", "PWY-6682", "PWY-6955", "PWY-7077", "PWY-7321", "PWY-7740", "PWY-7769", "PWY-7886", "PWY-7948", "PWY-7975", "PWY-8129", "PWY-8324", "PWY-8367", "PWY-8392", "PWY-8393", "PWY-8394", "PWY-8402" ]

[ "EC:2.7.1.-", "GP:GenProp0119", "METACYC:PWY-5129", "METACYC:PWY-6322", "METACYC:PWY-6369", "METACYC:PWY-6626", "METACYC:PWY-6682", "METACYC:PWY-6955", "METACYC:PWY-7077", "METACYC:PWY-7321", "METACYC:PWY-7740", "METACYC:PWY-7769", "METACYC:PWY-7886", "METACYC:PWY-7948", "METACYC:PWY-797...

22

[]

0

[ "PUB00000073", "PUB00002162", "PUB00003612", "PUB00013840", "PUB00017027", "PUB00017028" ]

[ "2197982", "1537788", "8246840", "7883710", "7815935", "11361063" ]

[ "The bacterial phosphoenolpyruvate: glycose phosphotransferase system.", "Proposed uniform nomenclature for the proteins and protein domains of the bacterial phosphoenolpyruvate: sugar phosphotransferase system.", "Phosphoenolpyruvate:carbohydrate phosphotransferase systems of bacteria.", "New beta-glucoside ...

[ 1990, 1992, 1993, 1995, 1994, 2001 ]

6

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 5537, 4, 5 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Phosphotransferase system, beta-glucoside-specific IIABC component

PTS_IIABC_b_glu

8

IPR011298

11,298

FeS A-type assembly protein SufA, proteobacteria

SufA_proteobacteria

Family

1,811

false

This entry represents the SufA protein of the SUF system of iron-sulphur cluster biosynthesis from proteobacteria. This system performs FeS biosynthesis even during oxidative stress and tends to be absent in obligate anaerobic and microaerophilic bacteria. A-type assembly protein (ATAP) is a conserved and essential mem...

[ "GO:0051536", "GO:0016226" ]

[ "iron-sulfur cluster binding", "iron-sulfur cluster assembly" ]

[ "molecular_function", "biological_process" ]

2

[ "NCBIFAM" ]

[ "TIGR01997" ]

[ "sufA_proteo" ]

[ 1811 ]

1

[ "GP" ]

[ "GenProp0137" ]

[ "GP:GenProp0137" ]

1

[ "2d2a" ]

1

[ "PUB00003442", "PUB00028014", "PUB00030961", "PUB00035635", "PUB00035636", "PUB00035637", "PUB00035638", "PUB00035639", "PUB00035640", "PUB00058194", "PUB00160405", "PUB00160406" ]

[ "8875867", "11498000", "15050828", "16221578", "16211402", "16843540", "15937904", "17350000", "15278785", "17698959", "32108236", "33007329" ]

[ "A modular domain of NifU, a nitrogen fixation cluster protein, is highly conserved in evolution.", "Incorporation of iron-sulphur clusters in membrane-bound proteins.", "Crystal structure of IscA, an iron-sulfur cluster assembly protein from Escherichia coli.", "How Escherichia coli and Saccharomyces cerevis...

[ 1996, 2001, 2004, 2005, 2005, 2006, 2005, 2007, 2004, 2007, 2020, 2021 ]

12

[ "IPR016092" ]

[]

1

0

1

[ "Bacteria", "Effrenium voratum", "metagenomes" ]

[ 1807, 1, 3 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

FeS A-type assembly protein SufA, proteobacteria

SufA_proteobacteria

8

IPR011299

11,299

PTS system glucose-specific IIBC component

PTS_IIBC_glc

Domain

3,357

false

This entry represents the combined B and C domains of the PTS transport system enzyme II specific for glucose transport [ ]. Many of the genes in this family also include an A domain as part of the same polypeptide and thus should be given the name 'PTS system, glucose-specific IIABC component' while the Bacillus subti...

[ "GO:0055056", "GO:1904659", "GO:0016020" ]

[ "D-glucose transmembrane transporter activity", "D-glucose transmembrane transport", "membrane" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "NCBIFAM" ]

[ "TIGR02002" ]

[ "PTS-II-BC-glcB" ]

[ 3357 ]

1

[ "EC", "GP" ]

[ "2.7.1.199", "GenProp0119" ]

[ "EC:2.7.1.199", "GP:GenProp0119" ]

2

[ "8qsr", "8qst", "9hnp" ]

3

[ "PUB00013751", "PUB00013794" ]

[ "3023349", "2120236" ]

[ "Glucose-permease of the bacterial phosphotransferase system. Gene cloning, overproduction, and amino acid sequence of enzyme IIGlc.", "The glucose permease of Bacillus subtilis is a single polypeptide chain that functions to energize the sucrose permease." ]

[ 1986, 1990 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "invertebrate metagenome" ]

[ 3351, 4, 2 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Domain

PTS system glucose-specific IIBC component

PTS_IIBC_glc

6

IPR011300

11,300

Phosphotransferase system, IIBC component

PTS_IIBC

Domain

1,382

false

This entry represents a group of fused B and C components of PTS enzyme II. This clade is a member of a larger family which contains enzyme II's specific for a variety of sugars including glucose ( ) and N-acetylglucosamine ( ). None of the members of this clade have been experimentally characterised. This clade includ...

[]

0

[ "NCBIFAM" ]

[ "TIGR02003" ]

[ "PTS-II-BC-unk1" ]

[ 1382 ]

1

[ "GP" ]

[ "GenProp0119" ]

[ "GP:GenProp0119" ]

1

[ "5iws", "6bvg" ]

2

[]

0

[]

0

null

[ "Bacteria", "bioreactor metagenome" ]

[ 1381, 1 ]

2

[]

0

true

Domain

Phosphotransferase system, IIBC component

PTS_IIBC

6

IPR011301

11,301

PTS system, maltose/glucose-specific IIBC component

PTS_Mal/Glc-sp_IIBC_component

Family

1,253

false

This entry represents a family of PTS enzyme II fused B and C components including and most closely related to the MalX maltose and glucose-specific transporter of Escherichia coli [ ].

[ "GO:0008982", "GO:0009401" ]

[ "protein-N(PI)-phosphohistidine-sugar phosphotransferase activity", "phosphoenolpyruvate-dependent sugar phosphotransferase system" ]

[ "molecular_function", "biological_process" ]

2

[ "NCBIFAM" ]

[ "TIGR02004" ]

[ "PTS-IIBC-malX" ]

[ 1253 ]

1

[ "GP" ]

[ "GenProp0119" ]

[ "GP:GenProp0119" ]

1

[]

0

[ "PUB00013824" ]

[ "1856179" ]

[ "The malX malY operon of Escherichia coli encodes a novel enzyme II of the phosphotransferase system recognizing glucose and maltose and an enzyme abolishing the endogenous induction of the maltose system." ]

[ 1991 ]

1

[]

0

null

[ "Bacteria", "Beauveria bassiana D1-5" ]

[ 1252, 1 ]

2

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

PTS system, maltose/glucose-specific IIBC component

PTS_Mal/Glc-sp_IIBC_component

4

IPR011302

11,302

FeS A-type assembly protein IscA, proteobacteria

IscA_proteobact

Family

4,271

false

This entry represents the IscA component of the ISC system for iron-sulphur cluster assembly. IscA is believed to act as a scaffold upon which 2Fe-2S clusters are assembled and subsequently transferred to ferredoxin [ , , ]. This clade is limited to the proteobacteria. A-type assembly protein (ATAP) is a conserved and ...

[ "GO:0051536", "GO:0016226" ]

[ "iron-sulfur cluster binding", "iron-sulfur cluster assembly" ]

[ "molecular_function", "biological_process" ]

2

[ "HAMAP", "NCBIFAM" ]

[ "MF_01429", "TIGR02011" ]

[ "Fe_S_insert_IscA", "IscA" ]

[ 915, 4271 ]

2

[ "GP" ]

[ "GenProp0138" ]

[ "GP:GenProp0138" ]

1

[ "1r94", "1r95", "1s98" ]

3

[ "PUB00003442", "PUB00013777", "PUB00013850", "PUB00028014", "PUB00035635", "PUB00035636", "PUB00035637", "PUB00035638", "PUB00035639", "PUB00035640", "PUB00035641", "PUB00058194", "PUB00160405", "PUB00160406" ]

[ "8875867", "11319236", "11432781", "11498000", "16221578", "16211402", "16843540", "15937904", "17350000", "15278785", "16730357", "17698959", "32108236", "33007329" ]

[ "A modular domain of NifU, a nitrogen fixation cluster protein, is highly conserved in evolution.", "Iron-sulfur cluster assembly: characterization of IscA and evidence for a specific and functional complex with ferredoxin.", "Genetic analysis of the isc operon in Escherichia coli involved in the biogenesis of ...

[ 1996, 2001, 2001, 2001, 2005, 2005, 2006, 2005, 2007, 2004, 2006, 2007, 2020, 2021 ]

14

[ "IPR016092" ]

[]

1

0

1

[ "Bacteria", "Eukaryota", "unclassified sequences", "uncultured Caudovirales phage" ]

[ 4208, 6, 55, 2 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

FeS A-type assembly protein IscA, proteobacteria

IscA_proteobact

2

IPR011303

11,303

Ion-translocating oxidoreductase complex subunit RnfD, bacterial

RnfD_bac

Family

7,336

false

This entry describes the D subunit. The six-subunit complex RnfABCDGE in Rhodobacter capsulatus (Rhodopseudomonas capsulata) encodes a NADH oxidoreductase responsible for electron transport to nitrogenase, necessary for nitrogen fixation [ ]. A closely related complex in Escherichia coli, RsxABCDGE (Reducer of SoxR), r...

[ "GO:0022900", "GO:0016020" ]

[ "electron transport chain", "membrane" ]

[ "biological_process", "cellular_component" ]

2

[ "HAMAP", "NCBIFAM" ]

[ "MF_00462", "TIGR01946" ]

[ "RsxD_RnfD", "rnfD" ]

[ 6905, 7246 ]

2

[ "GP" ]

[ "GenProp0130" ]

[ "GP:GenProp0130" ]

1

[ "7zc6", "8ahx", "8rb8", "8rb9", "8rbm", "8rbq", "9eri", "9erj", "9erk", "9erl" ]

10

[ "PUB00008135", "PUB00013513", "PUB00087510", "PUB00088392", "PUB00088393" ]

[ "9492268", "12773378", "27114876", "23269825", "24045950" ]

[ "Overexpression in Escherichia coli of the rnf genes from Rhodobacter capsulatus--characterization of two membrane-bound iron-sulfur proteins.", "A reducing system of the superoxide sensor SoxR in Escherichia coli.", "The role of Rnf in ion gradient formation in Desulfovibrio alaskensis.", "The Rnf complex of...

[ 1998, 2003, 2016, 2012, 2013 ]

5

[ "IPR004338" ]

[]

1

0

1

[ "Bacteria", "Eukaryota", "Methanobacteriota", "unclassified sequences" ]

[ 7198, 4, 5, 129 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Ion-translocating oxidoreductase complex subunit RnfD, bacterial

RnfD_bac

8

IPR011305

11,305

Energy-converting hydrogenase subunit EhaL family member MJ0518

MJ0518

Family

17

false

This entry represents Energy-converting hydrogenase subunit EhaL family member MJ0518 and related small membrane proteins that are predicted to be the EhaL transmembrane subunits of multisubunit membrane-bound [NiFe]-hydrogenase Eha complexes. Based on sequence similarity and genome context analysis, other organisms su...

[]

0

[ "PIRSF" ]

[ "PIRSF004953" ]

[ "EhaL" ]

[ 17 ]

1

[]

0

[]

0

[ "PUB00014600", "PUB00035516", "PUB00035517", "PUB00035518", "PUB00096941" ]

[ "10491142", "15168611", "16645307", "15119826", "22872868" ]

[ "Methanobacterium thermoautotrophicum encodes two multisubunit membrane-bound [NiFe] hydrogenases. Transcription of the operons and sequence analysis of the deduced proteins.", "Energy-converting [NiFe] hydrogenases from archaea and extremophiles: ancestors of complex I.", "Energy-converting [NiFe] hydrogenases...

[ 1999, 2004, 2005, 2004, 2012 ]

5

[ "IPR019211" ]

[]

1

0

1

[ "Methanomada group" ]

[ 17 ]

1

[]

0

true

Family

Energy-converting hydrogenase subunit EhaL family member MJ0518

MJ0518

1

IPR011307

11,307

Tetrahydromethanopterin S-methyltransferase, subunit F

MeTrfase_F

Family

100

false

This group represents a tetrahydromethanopterin S-methyltransferase, subunit F which forms part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step [ ]. The complex is c...

[ "GO:0030269", "GO:0015948", "GO:0016020" ]

[ "tetrahydromethanopterin S-methyltransferase activity", "methanogenesis", "membrane" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "HAMAP", "PIRSF" ]

[ "MF_01099", "PIRSF006523" ]

[ "MtrF", "MtrF" ]

[ 100, 65 ]

2

[ "EC" ]

[ "7.2.1.4" ]

[ "EC:7.2.1.4" ]

1

[ "8q3v", "8q54" ]

2

[ "PUB00005738" ]

[ "7737157" ]

[ "The energy conserving N5-methyltetrahydromethanopterin:coenzyme M methyltransferase complex from Methanobacterium thermoautotrophicum is composed of eight different subunits." ]

[ 1995 ]

1

[]

0

null

[ "Methanobacteriota", "ecological metagenomes" ]

[ 97, 3 ]

2

[]

0

true

Family

Tetrahydromethanopterin S-methyltransferase, subunit F

MeTrfase_F

3

IPR011308

11,308

Predicted [NiFe]-hydrogenase-3-type complex Eha, membrane protein EhaD

Prd_NiFe_hyd_3_EhaD

Family

31

false

[NiFe] hydrogenases function in H2 metabolism in a variety of microorganisms, enabling them to use H2 as a source of reducing equivalent under aerobic and anaerobic conditions [NiFe] hydrogenases consist of two subunits, hydrogenase large and hydrogenase small. The large subunit contains the binuclear [NiFe] active sit...

[]

0

[ "PIRSF" ]

[ "PIRSF006581" ]

[ "EhaD" ]

[ 31 ]

1

[]

0

[]

0

[ "PUB00014600", "PUB00035516", "PUB00035517", "PUB00035518", "PUB00096941" ]

[ "10491142", "15168611", "16645307", "15119826", "22872868" ]

[ "Methanobacterium thermoautotrophicum encodes two multisubunit membrane-bound [NiFe] hydrogenases. Transcription of the operons and sequence analysis of the deduced proteins.", "Energy-converting [NiFe] hydrogenases from archaea and extremophiles: ancestors of complex I.", "Energy-converting [NiFe] hydrogenases...

[ 1999, 2004, 2005, 2004, 2012 ]

5

[ "IPR019213" ]

[]

1

0

1

[ "Methanomada group" ]

[ 31 ]

1

[]

0

true

Family

Predicted [NiFe]-hydrogenase-3-type complex Eha, membrane protein EhaD

Prd_NiFe_hyd_3_EhaD

6

IPR011310

11,310

Lipopolysaccharide core heptose(II)-phosphate phosphatase

LipoPS_heptP_Pase

Family

802

false

This entry represents lipopolysaccharide core heptose(II)-phosphate phosphatase, which catalyzes the dephosphorylation of heptose(II) of the outer membrane lipopolysaccharide core. These proteins are related to cofactor-dependent phosphoglucomutases so distantly that the characteristic domain ( ) is not detected. Nonet...

[ "GO:0016791" ]

[ "phosphatase activity" ]

[ "molecular_function" ]

1

[ "HAMAP", "PIRSF" ]

[ "MF_01868", "PIRSF011416" ]

[ "Ais", "Ais-TraG-AfrS" ]

[ 562, 799 ]

2

[ "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC"...

[ "3.1.3.-", "PWY-4702", "PWY-5491", "PWY-6148", "PWY-6352", "PWY-6365", "PWY-6366", "PWY-6368", "PWY-6456", "PWY-6575", "PWY-6627", "PWY-6664", "PWY-6686", "PWY-6720", "PWY-6724", "PWY-6955", "PWY-6990", "PWY-6991", "PWY-7018", "PWY-7119", "PWY-7321", "PWY-7531", "PWY-7771...

[ "EC:3.1.3.-", "METACYC:PWY-4702", "METACYC:PWY-5491", "METACYC:PWY-6148", "METACYC:PWY-6352", "METACYC:PWY-6365", "METACYC:PWY-6366", "METACYC:PWY-6368", "METACYC:PWY-6456", "METACYC:PWY-6575", "METACYC:PWY-6627", "METACYC:PWY-6664", "METACYC:PWY-6686", "METACYC:PWY-6720", "METACYC:PWY-6...

36

[]

0

[ "PUB00014617" ]

[ "12586342" ]

[ "Unexpected catalytic site variation in phosphoprotein phosphatase homologues of cofactor-dependent phosphoglycerate mutase." ]

[ 2003 ]

1

[ "IPR013078" ]

[]

1

0

1

[ "Gammaproteobacteria", "Plasmid R64" ]

[ 801, 1 ]

2

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Lipopolysaccharide core heptose(II)-phosphate phosphatase

LipoPS_heptP_Pase

7

IPR011311

11,311

Predicted [NiFe]-hydrogenase-3-type complex Eha, membrane protein EhaG

Prd_NiFe_hyd_3_EhaG

Family

25

false

[NiFe] hydrogenases function in H2 metabolism in a variety of microorganisms, enabling them to use H2 as a source of reducing equivalent under aerobic and anaerobic conditions [NiFe] hydrogenases consist of two subunits, hydrogenase large and hydrogenase small. The large subunit contains the binuclear [NiFe] active sit...

[]

0

[ "PIRSF" ]

[ "PIRSF019136" ]

[ "EhaG" ]

[ 25 ]

1

[]

0

[]

0

[ "PUB00014600", "PUB00035516", "PUB00035517", "PUB00035518", "PUB00096941" ]

[ "10491142", "15168611", "16645307", "15119826", "22872868" ]

[ "Methanobacterium thermoautotrophicum encodes two multisubunit membrane-bound [NiFe] hydrogenases. Transcription of the operons and sequence analysis of the deduced proteins.", "Energy-converting [NiFe] hydrogenases from archaea and extremophiles: ancestors of complex I.", "Energy-converting [NiFe] hydrogenases...

[ 1999, 2004, 2005, 2004, 2012 ]

5

[ "IPR019212" ]

[]

1

0

1

[ "Methanomada group" ]

[ 25 ]

1

[]

0

true

Family

Predicted [NiFe]-hydrogenase-3-type complex Eha, membrane protein EhaG

Prd_NiFe_hyd_3_EhaG

1

IPR011312

11,312

Methanogenesis marker 7 protein

Menthan_mark_7

Family

256

false

Members of this protein family, to date, are found in a completed prokaryotic genome if, and only if, the species is one of the archaeal methanogens. The exact function is unknown, but likely is linked to methanogenesis or a process closely connected to it [ ].

[]

0

[ "PIRSF", "NCBIFAM" ]

[ "PIRSF019164", "TIGR03274" ]

[ "UCP019164", "methan_mark_7" ]

[ 256, 236 ]

2

[ "GP" ]

[ "GenProp0722" ]

[ "GP:GenProp0722" ]

1

[ "8s7v", "8s7x", "9h1l" ]

3

[ "PUB00060475" ]

[ "22070167" ]

[ "ProPhylo: partial phylogenetic profiling to guide protein family construction and assignment of biological process." ]

[ 2011 ]

1

[ "IPR026327" ]

[]

1

0

1

[ "Archaea", "ecological metagenomes" ]

[ 250, 6 ]

2

[]

0

true

Family

Methanogenesis marker 7 protein

Menthan_mark_7

9

IPR011314

11,314

Predicted [NiFe]-hydrogenase-3-type complex Eha, membrane protein EhaB

Prd_NiFe_hyd_3_EhaB

Family

127

false

[NiFe] hydrogenases function in H2 metabolism in a variety of microorganisms, enabling them to use H2 as a source of reducing equivalent under aerobic and anaerobic conditions [NiFe] hydrogenases consist of two subunits, hydrogenase large and hydrogenase small. The large subunit contains the binuclear [NiFe] active sit...

[]

0

[ "PFAM", "PIRSF" ]

[ "PF26645", "PIRSF019706" ]

[ "EhaB", "EhaB" ]

[ 127, 114 ]

2

[]

0

[]

0

[ "PUB00014600", "PUB00035516", "PUB00035517", "PUB00035518", "PUB00096941", "PUB00161043" ]

[ "10491142", "15168611", "16645307", "15119826", "22872868", "19495416" ]

[ "Methanobacterium thermoautotrophicum encodes two multisubunit membrane-bound [NiFe] hydrogenases. Transcription of the operons and sequence analysis of the deduced proteins.", "Energy-converting [NiFe] hydrogenases from archaea and extremophiles: ancestors of complex I.", "Energy-converting [NiFe] hydrogenases...

[ 1999, 2004, 2005, 2004, 2012, 2009 ]

6

[]

0

null

[ "Methanobacteriota", "ecological metagenomes" ]

[ 124, 3 ]

2

[]

0

true

Family

Predicted [NiFe]-hydrogenase-3-type complex Eha, membrane protein EhaB

Prd_NiFe_hyd_3_EhaB

9

IPR011315

11,315

NTP pyrophosphohydrolase MazG-related, Rhizobiaceae-type

MazG-related_Rhizo-type

Family

75

false

Members of this group are distantly related to MazG-type NTP pyrophosphohydrolase. Conserved residues of the MazG domain (at least three of the Glu residues, Asp, Lys and Arg), including those shown to be functionally important [ ], are also conserved here. MazG protein of Thermotoga maritima has been shown to have bot...

[]

0

[ "PIRSF" ]

[ "PIRSF036522" ]

[ "UCP036522_pph" ]

[ 75 ]

1

[]

0

[]

0

[ "PUB00013554", "PUB00014610" ]

[ "12657645", "12218018" ]

[ "Thermotoga maritima MazG protein has both nucleoside triphosphate pyrophosphohydrolase and pyrophosphatase activities.", "MazG, a nucleoside triphosphate pyrophosphohydrolase, interacts with Era, an essential GTPase in Escherichia coli." ]

[ 2003, 2002 ]

2

[]

0

null

[ "Hyphomicrobiales" ]

[ 75 ]

1

[]

0

true

Family

NTP pyrophosphohydrolase MazG-related, Rhizobiaceae-type

MazG-related_Rhizo-type

2

IPR011318

11,318

Predicted [NiFe]-hydrogenase-3-type complex Eha, membrane protein EhaI

Prd_NiFe_hyd_3_EhaI

Family

43

false

[NiFe] hydrogenases function in H2 metabolism in a variety of microorganisms, enabling them to use H2 as a source of reducing equivalent under aerobic and anaerobic conditions [NiFe] hydrogenases consist of two subunits, hydrogenase large and hydrogenase small. The large subunit contains the binuclear [NiFe] active sit...

[]

0

[ "PFAM", "PIRSF" ]

[ "PF27656", "PIRSF036537" ]

[ "Prd_NiFe_hyd_3_EhaI", "EhaI" ]

[ 43, 5 ]

2

[]

0

[]

0

[ "PUB00014600", "PUB00035516", "PUB00035517", "PUB00035518", "PUB00096941" ]

[ "10491142", "15168611", "16645307", "15119826", "22872868" ]

[ "Methanobacterium thermoautotrophicum encodes two multisubunit membrane-bound [NiFe] hydrogenases. Transcription of the operons and sequence analysis of the deduced proteins.", "Energy-converting [NiFe] hydrogenases from archaea and extremophiles: ancestors of complex I.", "Energy-converting [NiFe] hydrogenases...

[ 1999, 2004, 2005, 2004, 2012 ]

5

[]

0

null

[ "Methanobacteriaceae", "bioreactor metagenome" ]

[ 42, 1 ]

2

[]

0

true

Family

Predicted [NiFe]-hydrogenase-3-type complex Eha, membrane protein EhaI

Prd_NiFe_hyd_3_EhaI

8

IPR011319

11,319

Predicted [NiFe]-hydrogenase-3-type complex Eha, membrane protein EhaK

Prd_NiFe_hyd_3_EhaK

Family

67

false

[NiFe] hydrogenases function in H2 metabolism in a variety of microorganisms, enabling them to use H2 as a source of reducing equivalent under aerobic and anaerobic conditions [NiFe] hydrogenases consist of two subunits, hydrogenase large and hydrogenase small. The large subunit contains the binuclear [NiFe] active sit...

[]

0

[ "PFAM", "PIRSF" ]

[ "PF27339", "PIRSF036538" ]

[ "Prd_NiFe_hyd_3_EhaK", "EhaK" ]

[ 67, 11 ]

2

[]

0

[]

0

[ "PUB00014600", "PUB00035516", "PUB00035517", "PUB00035518", "PUB00096941" ]

[ "10491142", "15168611", "16645307", "15119826", "22872868" ]

[ "Methanobacterium thermoautotrophicum encodes two multisubunit membrane-bound [NiFe] hydrogenases. Transcription of the operons and sequence analysis of the deduced proteins.", "Energy-converting [NiFe] hydrogenases from archaea and extremophiles: ancestors of complex I.", "Energy-converting [NiFe] hydrogenases...

[ 1999, 2004, 2005, 2004, 2012 ]

5

[]

0

null

[ "Methanomada group", "bioreactor metagenome" ]

[ 66, 1 ]

2

[]

0

true

Family

Predicted [NiFe]-hydrogenase-3-type complex Eha, membrane protein EhaK

Prd_NiFe_hyd_3_EhaK

4

IPR011320

11,320

Ribonuclease H1, N-terminal

RNase_H1_N

Domain

14,346

false

This entry represents the N-terminal domain of RNase HI, which has a 3-layer α/β/α structure [ ]. This domain is lacking in retroviral and prokaryotic enzymes, but shows a striking structural similarity to the ribosomal protein L9 N-terminal domain, and may function as a regulatory RNA-binding module. However, the topo...

[]

0

[ "PFAM" ]

[ "PF01693" ]

[ "Cauli_VI" ]

[ 14346 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-2995383", "R-HSA-9013404", "R-HSA-9013408", "R-HSA-9913635", "R-RNO-2995383", "R-RNO-9013404", "R-RNO-9013408" ]

[ "REACTOME:R-HSA-2995383", "REACTOME:R-HSA-9013404", "REACTOME:R-HSA-9013408", "REACTOME:R-HSA-9913635", "REACTOME:R-RNO-2995383", "REACTOME:R-RNO-9013404", "REACTOME:R-RNO-9013408" ]

7

[ "1qhk", "3bsu", "6vrd", "8swc" ]

4

[ "PUB00011751" ]

[ "10448044" ]

[ "NMR structure of the N-terminal domain of Saccharomyces cerevisiae RNase HI reveals a fold with a strong resemblance to the N-terminal domain of ribosomal protein L9." ]

[ 1999 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "Methanobacteriati", "Viruses", "metagenomes" ]

[ 3553, 10479, 21, 211, 82 ]

5

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", ...

[ 3, 5, 3, 6, 3, 1, 2, 8, 1, 1, 14 ]

11

true

Domain

Ribonuclease H1, N-terminal

RNase_H1_N

3

IPR011322

11,322

Nitrogen regulatory PII-like, alpha/beta

N-reg_PII-like_a/b

Homologous_superfamily

73,938

false

This superfamily represents a structural domain found in the nitrogen regulatory protein PII, in ATP phosphribosyltransferases (C-terminal domain), in the divalent ion tolerance protein CutA1, and in some bacterial hypothetical proteins. This domain consists of a ferredoxin-like α/β sandwich, which forms trimeric struc...

[]

0

[ "SSF" ]

[ "SSF54913" ]

[ "" ]

[ 73938 ]

1

[ "EC" ]

[ "2.4.2.17" ]

[ "EC:2.4.2.17" ]

1

[ "1gnk", "1h3d", "1hwu", "1j2v", "1kr4", "1naq", "1nh7", "1nh8", "1nza", "1o51", "1o5j", "1osc", "1p1l", "1pil", "1q1k", "1qy7", "1ufl", "1uku", "1ul3", "1umj", "1v3r", "1v3s", "1v6h", "1v9o", "1vfj", "1vhf", "1xk8", "2cz4", "2dcl", "2e66", "2eg1", "2eg2"...

173

[ "PUB00003738", "PUB00007506", "PUB00014093", "PUB00022501", "PUB00035665", "PUB00035666" ]

[ "1702507", "7623666", "12949080", "14741209", "16860774", "17077491" ]

[ "Characterization of three different nitrogen-regulated promoter regions for the expression of glnB and glnA in Azospirillum brasilense.", "Molecular genetics of a chromosomal locus involved in copper tolerance in Escherichia coli K-12.", "The evolutionarily conserved trimeric structure of CutA1 proteins sugges...

[ 1990, 1995, 2003, 2004, 2006, 2006 ]

6

[]

0

null

[ "Archaea", "Bacteria", "Caudoviricetes", "Eukaryota", "unclassified sequences" ]

[ 2966, 62777, 3, 6603, 1589 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus",...

[ 18, 1, 6, 2, 4, 4, 5, 1, 9, 10, 1, 1, 11 ]

13

true

Homologous_superfamily

Nitrogen regulatory PII-like, alpha/beta

N-reg_PII-like_a/b

8

IPR011323

11,323

Mss4/translationally controlled tumour-associated TCTP

Mss4/transl-control_tumour

Homologous_superfamily

8,189

false

This superfamily represents a structural domain with a complex fold consisting of several coiled β-sheets. This domain exists as a duplication, consisting of a tandem repeat of two similar structural motifs. This entry represents copies of this structural motif in the following protein families: Mss4, which contains a ...

[]

0

[ "CATHGENE3D" ]

[ "G3DSA:2.170.150.10" ]

[ "" ]

[ 8189 ]

1

[]

0

[ "1fwq", "1h6q", "1h7y", "1hxr", "1txj", "1yz1", "2fu5", "2hr9", "2kwb", "2loy", "3ebm", "3p3k", "5o9k", "5o9l", "5o9m", "6izb", "6ize", "6j2y" ]

18

[ "PUB00007168", "PUB00014250" ]

[ "11473261", "11258916" ]

[ "Structure of TCTP reveals unexpected relationship with guanine nucleotide-free chaperones.", "A helical turn motif in Mss4 is a critical determinant of Rab binding and nucleotide release." ]

[ 2001, 2001 ]

2

[]

0

null

[ "Bacteria", "Eukaryota" ]

[ 24, 8165 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 9, 4, 3, 5, 16, 5, 1, 3, 11, 2, 2, 17 ]

12

true

Homologous_superfamily

Mss4/translationally controlled tumour-associated TCTP

Mss4/transl-control_tumour

9

IPR011324

11,324

Cytotoxic necrotizing factor-like, catalytic

Cytotoxic_necrot_fac-like_cat

Homologous_superfamily

30,732

false

This entry represents the catalytic domain from several bacterial cytotoxic necrotizing factor proteins and the related dermonecrotic toxin (DNT) from Bordetella species. Cytotoxic necrotizing factor 1 (CNF1) is a toxin which in Escherichia coli forms a 4-layer α/β/β/α structure containing mixed β-sheets [ ]. CNF1 is e...

[]

0

[ "SSF" ]

[ "SSF64438" ]

[ "" ]

[ 30732 ]

1

[ "EC" ]

[ "3.5.1.44" ]

[ "EC:3.5.1.44" ]

1

[ "1hq0", "1hzg", "1rv9", "1rw0", "1t8h", "1u05", "1xaf", "1xfj", "1z9t", "2f9z", "6dzd", "6t0y", "6t1b", "6yhk", "6yhm", "6yhn", "7f3v", "7fbg", "7w1g" ]

19

[ "PUB00011275", "PUB00011276", "PUB00019322", "PUB00035667" ]

[ "12622819", "12065482", "11427886", "16498617" ]

[ "Expression of cnf1 by Escherichia coli J96 involves a large upstream DNA region including the hlyCABD operon, and is regulated by the RfaH protein.", "Identification of a receptor-binding domain of Bordetella dermonecrotic toxin.", "Structure of the Rho-activating domain of Escherichia coli cytotoxic necrotizi...

[ 2003, 2002, 2001, 2006 ]

4

[]

0

null

[ "Archaea", "Bacteria", "Caudoviricetes", "Eukaryota", "unclassified sequences" ]

[ 500, 28629, 2, 1006, 595 ]

5

[ "Danio rerio", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 1, 3, 2, 3 ]

5

true

Homologous_superfamily

Cytotoxic necrotizing factor-like, catalytic

Cytotoxic_necrot_fac-like_cat

1

IPR011327

11,327

Killer toxin, SMK, beta subunit

Killer_tox_SMK_b

Domain

4

false

This entry represents the beta subunit of SMK killer toxins that are secreted by several strains of yeasts. SMK toxin is encoded by a single open reading frame of chromosomal DNA (the SMK1 gene) and is translated in the form of a 222 amino acid preprotoxin. This preprotoxin is converted to the alpha and beta heterodime...

[]

0

[ "PFAM", "CDD" ]

[ "PF21414", "cd12839" ]

[ "SMK_beta_su", "Killer_toxin_beta" ]

[ 4, 4 ]

2

[]

0

[ "1kvd", "1kve" ]

2

[ "PUB00035671", "PUB00035672" ]

[ "9016714", "11748724" ]

[ "The novel acidophilic structure of the killer toxin from halotolerant yeast demonstrates remarkable folding similarity with a fungal killer toxin.", "Interaction of SMKT, a killer toxin produced by Pichia farinosa, with the yeast cell membranes." ]

[ 1997, 2001 ]

2

[]

0

null

[ "Debaryomycetaceae" ]

[ 4 ]

1

[]

0

true

Domain

Killer toxin, SMK, beta subunit

Killer_tox_SMK_b

6

IPR011328

11,328

Salt-mediated killer toxin, alpha subunit

SMK_a

Homologous_superfamily

3

false

The killer toxin SMK (salt-mediated killer) from the halotolerant yeast Pichia farinosa acts to kill sensitive strains of yeast. SMK exhibits maximum activity under conditions of acidic pH and high salt concentration. It is composed of two distinct subunits, alpha and beta, which tightly interact with each other under ...

[]

0

[ "CATHGENE3D" ]

[ "G3DSA:4.10.420.10" ]

[ "" ]

[ 3 ]

1

[]

0

[ "1kvd", "1kve" ]

2

[ "PUB00035671", "PUB00035672" ]

[ "9016714", "11748724" ]

[ "The novel acidophilic structure of the killer toxin from halotolerant yeast demonstrates remarkable folding similarity with a fungal killer toxin.", "Interaction of SMKT, a killer toxin produced by Pichia farinosa, with the yeast cell membranes." ]

[ 1997, 2001 ]

2

[]

0

null

[ "Millerozyma farinosa" ]

[ 3 ]

1

[]

0

true

Homologous_superfamily

Salt-mediated killer toxin, alpha subunit

SMK_a

2

IPR011329

11,329

Killer toxin Kp4/SMK

Killer_tox_Kp4/SMK

Homologous_superfamily

966

false

This superfamily represents a structural fold found in the killer toxins Kp4 and SMK, consisting of two left-handed split β/αβ motifs, which is rarely found in other toxins; hence, these toxins may be evolutionarily or functionally related [ ]. Killer toxins are polypeptides secreted by some fungal species that kill se...

[ "GO:0005576" ]

[ "extracellular region" ]

[ "cellular_component" ]

1

[ "SSF" ]

[ "SSF55221" ]

[ "" ]

[ 966 ]

1

[]

0

[ "1kpt", "1kvd", "1kve" ]

3

[ "PUB00028852", "PUB00035671", "PUB00035672", "PUB00035673" ]

[ "7582897", "9016714", "11748724", "8145639" ]

[ "Structure and function of a virally encoded fungal toxin from Ustilago maydis: a fungal and mammalian Ca2+ channel inhibitor.", "The novel acidophilic structure of the killer toxin from halotolerant yeast demonstrates remarkable folding similarity with a fungal killer toxin.", "Interaction of SMKT, a killer to...

[ 1995, 1997, 2001, 1994 ]

4

[]

0

null

[ "Eukaryota", "Laribacter hongkongensis", "Ustilago maydis P4 virus" ]

[ 963, 2, 1 ]

3

[]

0

true

Homologous_superfamily

Killer toxin Kp4/SMK

Killer_tox_Kp4/SMK

8

IPR011330

11,330

Glycoside hydrolase/deacetylase, beta/alpha-barrel

Glyco_hydro/deAcase_b/a-brl

Homologous_superfamily

201,770

false

This superfamily represents a structural domain found in glycoside hydrolase family 38 ( , e.g. alpha-mannosidase) [ ] and 57 ( , e.g. 4-alpha-glucanotransferase, N-terminal) [ ], as well as in NodB-like polysaccharide deacetylase and in some hypothetical proteins (e.g. TT1467, N-terminal domain). This domain consists ...

[ "GO:0005975" ]

[ "carbohydrate metabolic process" ]

[ "biological_process" ]

1

[ "SSF" ]

[ "SSF88713" ]

[ "" ]

[ 201770 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-4085001", "R-BTA-6798695", "R-BTA-8853383", "R-DDI-6798695", "R-DDI-8853383", "R-DME-975578", "R-HSA-4085001", "R-HSA-6798695", "R-HSA-6811438", "R-HSA-8853383", "R-HSA-9694548", "R-HSA-975578", "R-MMU-4085001", "R-MMU-6798695", "R-MMU-8853383", "R-MMU-975578", "R-RNO-4085001"...

[ "REACTOME:R-BTA-4085001", "REACTOME:R-BTA-6798695", "REACTOME:R-BTA-8853383", "REACTOME:R-DDI-6798695", "REACTOME:R-DDI-8853383", "REACTOME:R-DME-975578", "REACTOME:R-HSA-4085001", "REACTOME:R-HSA-6798695", "REACTOME:R-HSA-6811438", "REACTOME:R-HSA-8853383", "REACTOME:R-HSA-9694548", "REACTOME...

21

[ "1hty", "1hww", "1hxk", "1k1w", "1k1x", "1k1y", "1ny1", "1o7d", "1ps3", "1qwn", "1qwu", "1qx1", "1r33", "1r34", "1tqs", "1tqt", "1tqu", "1tqv", "1tqw", "1ufa", "1v6t", "1w17", "1w1a", "1w1b", "1xw8", "1z7a", "2alw", "2b5d", "2c1g", "2c1i", "2c71", "2c79"...

211

[ "PUB00014074", "PUB00030417" ]

[ "12618437", "12960159" ]

[ "Crystal structures of 4-alpha-glucanotransferase from Thermococcus litoralis and its complex with an inhibitor.", "Insights into the mechanism of Drosophila melanogaster Golgi alpha-mannosidase II through the structural analysis of covalent reaction intermediates." ]

[ 2003, 2003 ]

2

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 3085, 156352, 39957, 71, 2305 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus",...

[ 31, 21, 25, 44, 7, 27, 25, 8, 13, 31, 3, 2, 56 ]

13

true

Homologous_superfamily

Glycoside hydrolase/deacetylase, beta/alpha-barrel

Glyco_hydro/deAcase_b/a-brl

7

IPR011331

11,331

Large ribosomal subunit protein eL37/eL43

Ribosomal_eL37/eL43

Homologous_superfamily

13,424

false

This superfamily represents the core domain of the large ribosomal subunit protein eL37/eL43 from archaea and eukaryotes, which where previously known as ribosomal proteins L37ae and L37e. Members of this group share a common rubredoxin-like metal-binding fold containing two CX(n)C motifs (where n is usually two) [ ].

[ "GO:0003735", "GO:0006412", "GO:0005840" ]

[ "structural constituent of ribosome", "translation", "ribosome" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "CATHGENE3D" ]

[ "G3DSA:2.20.25.30" ]

[ "" ]

[ 13424 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-156827", "R-BTA-1799339", "R-BTA-6791226", "R-BTA-72689", "R-BTA-72706", "R-BTA-975956", "R-BTA-975957", "R-CEL-156827", "R-CEL-1799339", "R-CEL-72689", "R-CEL-72706", "R-CEL-975956", "R-CEL-975957", "R-DDI-156827", "R-DDI-1799339", "R-DDI-72689", "R-DDI-72706", "R-DDI-97595...

[ "REACTOME:R-BTA-156827", "REACTOME:R-BTA-1799339", "REACTOME:R-BTA-6791226", "REACTOME:R-BTA-72689", "REACTOME:R-BTA-72706", "REACTOME:R-BTA-975956", "REACTOME:R-BTA-975957", "REACTOME:R-CEL-156827", "REACTOME:R-CEL-1799339", "REACTOME:R-CEL-72689", "REACTOME:R-CEL-72706", "REACTOME:R-CEL-9759...

64

[ "1ffk", "1jj2", "1k73", "1k8a", "1k9m", "1kc8", "1kd1", "1kqs", "1m1k", "1m90", "1n8r", "1nji", "1q7y", "1q81", "1q82", "1q86", "1qvf", "1qvg", "1s72", "1vq4", "1vq5", "1vq6", "1vq7", "1vq8", "1vq9", "1vqk", "1vql", "1vqm", "1vqn", "1vqo", "1vqp", "1w2b"...

681

[ "PUB00030943" ]

[ "15184028" ]

[ "The roles of ribosomal proteins in the structure assembly, and evolution of the large ribosomal subunit." ]

[ 2004 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "ecological metagenomes" ]

[ 1694, 34, 11656, 40 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 18, 3, 2, 7, 11, 8, 2, 10, 14, 4, 4, 41 ]

12

true

Homologous_superfamily

Large ribosomal subunit protein eL37/eL43

Ribosomal_eL37/eL43

6

IPR011332

11,332

Zinc-binding ribosomal protein

Ribosomal_zn-bd

Homologous_superfamily

124,548

false

This superfamily represents a rubredoxin-like metal-binding fold found in bL32, bL33, eL37, eL43, eL40, eL42 and other ribosomal proteins. This domain contains two CX(n)C motifs (where n is usually two) [ , ].

[ "GO:0006412" ]

[ "translation" ]

[ "biological_process" ]

1

[ "SSF" ]

[ "SSF57829" ]

[ "" ]

[ 124548 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-110312", "R-BTA-110314", "R-BTA-110320", "R-BTA-1169091", "R-BTA-1234176", "R-BTA-1253288", "R-BTA-1295596", "R-BTA-1358803", "R-BTA-141444", "R-BTA-156827", "R-BTA-168638", "R-BTA-174048", "R-BTA-174084", "R-BTA-174113", "R-BTA-174154", "R-BTA-174178", "R-BTA-174184", "R-BT...

[ "REACTOME:R-BTA-110312", "REACTOME:R-BTA-110314", "REACTOME:R-BTA-110320", "REACTOME:R-BTA-1169091", "REACTOME:R-BTA-1234176", "REACTOME:R-BTA-1253288", "REACTOME:R-BTA-1295596", "REACTOME:R-BTA-1358803", "REACTOME:R-BTA-141444", "REACTOME:R-BTA-156827", "REACTOME:R-BTA-168638", "REACTOME:R-BT...

1,135

[ "1ffk", "1j5a", "1jj2", "1jzx", "1jzy", "1jzz", "1k01", "1k73", "1k8a", "1k9m", "1kc8", "1kd1", "1kqs", "1m1k", "1m90", "1n8r", "1nji", "1nkw", "1nwx", "1nwy", "1ond", "1q7y", "1q81", "1q82", "1q86", "1qvf", "1qvg", "1qxf", "1s72", "1sm1", "1vq4", "1vq5"...

2,208

[ "PUB00030432", "PUB00030943" ]

[ "15096641", "15184028" ]

[ "The NMR solution structure of the 30S ribosomal protein S27e encoded in gene RS27_ARCFU of Archaeoglobus fulgidis reveals a novel protein fold.", "The roles of ribosomal proteins in the structure assembly, and evolution of the large ribosomal subunit." ]

[ 2004, 2004 ]

2

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 5048, 53357, 65287, 19, 837 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus",...

[ 63, 7, 11, 15, 3, 35, 28, 8, 54, 50, 11, 10, 84 ]

13

true

Homologous_superfamily

Zinc-binding ribosomal protein

Ribosomal_zn-bd

3

IPR011334

11,334

UDP-3-O-acyl N-acetylglucosamine deacetylase, C-terminal

UDP-acyl_GlcNac_deAcase_C

Homologous_superfamily

14,486

false

This superfamily represents the C-terminal domain. UDP-3-O-N-acetylglucosamine deacetylases are zinc-dependent metalloamidases that catalyse the second and committed step in the biosynthesis of lipid A. Lipid A anchors lipopolysaccharide (the major constituent of the outer membrane) into the membrane in Gram-negative b...

[ "GO:0103117", "GO:0009245" ]

[ "UDP-3-O-acyl-N-acetylglucosamine deacetylase activity", "lipid A biosynthetic process" ]

[ "molecular_function", "biological_process" ]

2

[ "CATHGENE3D" ]

[ "G3DSA:3.30.1700.10" ]

[ "" ]

[ 14486 ]

1

[ "EC", "METACYC", "METACYC", "METACYC" ]

[ "3.5.1.108", "PWY-8073", "PWY-8245", "PWY-8283" ]

[ "EC:3.5.1.108", "METACYC:PWY-8073", "METACYC:PWY-8245", "METACYC:PWY-8283" ]

4

[ "1p42", "1xxe", "1yh8", "1yhc", "2go3", "2go4", "2ier", "2ies", "2j65", "2jt2", "2o3z", "2ves", "3nzk", "3p3c", "3p3e", "3p3g", "3p76", "3ps1", "3ps2", "3ps3", "3u1y", "3uhm", "4fw3", "4fw4", "4fw5", "4fw6", "4fw7", "4is9", "4isa", "4j3d", "4lcf", "4lcg"...

95

[ "PUB00029703", "PUB00032543", "PUB00035690" ]

[ "12819349", "15667205", "17296300" ]

[ "Crystal structure of LpxC, a zinc-dependent deacetylase essential for endotoxin biosynthesis.", "Refined solution structure of the LpxC-TU-514 complex and pKa analysis of an active site histidine: insights into the mechanism and inhibitor design.", "Amphipathic benzoic acid derivatives: synthesis and binding i...

[ 2003, 2005, 2007 ]

3

[]

0

null

[ "Bacteria", "Candidatus Iainarchaeum sp.", "Eukaryota", "unclassified sequences" ]

[ 13415, 1, 781, 289 ]

4

[ "Arabidopsis thaliana", "Escherichia coli (strain K12)", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 10, 1, 6, 5 ]

4

true

Homologous_superfamily

UDP-3-O-acyl N-acetylglucosamine deacetylase, C-terminal

UDP-acyl_GlcNac_deAcase_C

5

IPR011335

11,335

Restriction endonuclease type II-like

Restrct_endonuc-II-like

Homologous_superfamily

230,831

false

This superfamily represents the core structure found in most type II restriction endonucleases, consisting of a 3-layer α/β/α topology with mixed β-sheets. This core structure can be found in the restriction endonucleases EcoRI, EcoRV, BamHI, BglI, BglII, BstyI, PvuII, MunI, NseI, NgoIV, BsobI, HincII, MspI, FokI (C-te...

[]

0

[ "SSF" ]

[ "SSF52980" ]

[ "" ]

[ 230831 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-5685938", "R-BTA-5696395", "R-BTA-5696400", "R-BTA-6782135", "R-BTA-6783310", "R-DDI-5696395", "R-DDI-6782135", "R-DME-5696395", "R-DME-5696400", "R-DME-6782135", "R-DRE-5693568", "R-HSA-5685938", "R-HSA-5693568", "R-HSA-5696395", "R-HSA-5696400", "R-HSA-6782135", "R-HSA-67833...

[ "REACTOME:R-BTA-5685938", "REACTOME:R-BTA-5696395", "REACTOME:R-BTA-5696400", "REACTOME:R-BTA-6782135", "REACTOME:R-BTA-6783310", "REACTOME:R-DDI-5696395", "REACTOME:R-DDI-6782135", "REACTOME:R-DME-5696395", "REACTOME:R-DME-5696400", "REACTOME:R-DME-6782135", "REACTOME:R-DRE-5693568", "REACTOM...

36

[ "1avq", "1az0", "1az3", "1az4", "1azo", "1b94", "1b95", "1b96", "1b97", "1bam", "1bgb", "1bhm", "1bss", "1bsu", "1bua", "1cfr", "1ckq", "1cl8", "1cw0", "1d02", "1d2i", "1dc1", "1dfm", "1dmu", "1eo3", "1eo4", "1eon", "1eoo", "1eop", "1eri", "1es8", "1esg"...

265

[ "PUB00035691", "PUB00035692", "PUB00035693", "PUB00035694" ]

[ "15770420", "14576294", "11827971", "11557805" ]

[ "Type II restriction endonucleases: structure and mechanism.", "Diversity of type II restriction endonucleases that require two DNA recognition sites.", "Evolutionary relationship between different subgroups of restriction endonucleases.", "Structure and function of type II restriction endonucleases." ]

[ 2005, 2003, 2002, 2001 ]

4

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "plasmids", "unclassified sequences" ]

[ 5113, 191614, 26602, 3772, 2, 3728 ]

6

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus",...

[ 28, 4, 31, 6, 9, 35, 12, 4, 13, 29, 3, 4, 38 ]

13

true

Homologous_superfamily

Restriction endonuclease type II-like

Restrct_endonuc-II-like

8

IPR011336

11,336

Restriction endonuclease, type II, EcoRI/MunI

Restrct_endonuc_II_EcoRI/MunI

Homologous_superfamily

203

false

There are four classes of restriction endonucleases: types I, II, III and IV. All types of enzymes recognise specific short DNA sequences and carry out the endonucleolytic cleavage of DNA to give specific double-stranded fragments with terminal 5'-phosphates. They differ in their recognition sequence, subunit compositi...

[ "GO:0003677", "GO:0009036", "GO:0009307" ]

[ "DNA binding", "type II site-specific deoxyribonuclease activity", "DNA restriction-modification system" ]

[ "molecular_function", "molecular_function", "biological_process" ]

3

[ "CATHGENE3D" ]

[ "G3DSA:3.40.580.10" ]

[ "" ]

[ 203 ]

1

[ "EC" ]

[ "3.1.21.4" ]

[ "EC:3.1.21.4" ]

1

[ "1ckq", "1cl8", "1d02", "1eri", "1qc9", "1qps", "1qrh", "1qri", "2oxv" ]

9

[ "PUB00035691", "PUB00035692", "PUB00035693", "PUB00035694", "PUB00035695", "PUB00035696", "PUB00035705", "PUB00035707" ]

[ "15770420", "14576294", "11827971", "11557805", "11170385", "11732916", "15121719", "12665693" ]

[ "Type II restriction endonucleases: structure and mechanism.", "Diversity of type II restriction endonucleases that require two DNA recognition sites.", "Evolutionary relationship between different subgroups of restriction endonucleases.", "Structure and function of type II restriction endonucleases.", "Sol...

[ 2005, 2003, 2002, 2001, 2001, 2001, 2004, 2003 ]

8

[]

0

null

[ "Archaea", "Bacteria", "Cetraspora pellucida", "Plasmid P6", "metagenomes", "virus sp. ctr1v16" ]

[ 2, 190, 2, 1, 7, 1 ]

6

[]

0

true

Homologous_superfamily

Restriction endonuclease, type II, EcoRI/MunI

Restrct_endonuc_II_EcoRI/MunI

3

IPR011337

11,337

DNA mismatch repair MutH/Type II restriction enzyme Sau3AI

DNA_rep_MutH/RE_typeII_Sau3AI

Domain

3,352

false

There are four classes of restriction endonucleases: types I, II, III and IV. All types of enzymes recognise specific short DNA sequences and carry out the endonucleolytic cleavage of DNA to give specific double-stranded fragments with terminal 5'-phosphates. They differ in their recognition sequence, subunit compositi...

[ "GO:0003677", "GO:0004519" ]

[ "DNA binding", "endonuclease activity" ]

[ "molecular_function", "molecular_function" ]

2

[ "PFAM", "SMART", "CDD" ]

[ "PF02976", "SM00927", "cd00583" ]

[ "MutH", "MutH", "MutH-like" ]

[ 3352, 3272, 2489 ]

3

[]

0

[ "1azo", "2aoq", "2aor", "2azo", "4pxg" ]

5

[ "PUB00007435", "PUB00035691", "PUB00035692", "PUB00035693", "PUB00035694", "PUB00035697", "PUB00035705", "PUB00035707" ]

[ "9482749", "15770420", "14576294", "11827971", "11557805", "11316811", "15121719", "12665693" ]

[ "Structural basis for MutH activation in E.coli mismatch repair and relationship of MutH to restriction endonucleases.", "Type II restriction endonucleases: structure and mechanism.", "Diversity of type II restriction endonucleases that require two DNA recognition sites.", "Evolutionary relationship between d...

[ 1998, 2005, 2003, 2002, 2001, 2001, 2004, 2003 ]

8

[]

0

null

[ "Bacteria", "Beauveria bassiana D1-5", "Methanobacteriati", "metagenomes" ]

[ 3308, 1, 11, 32 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Domain

DNA mismatch repair MutH/Type II restriction enzyme Sau3AI

DNA_rep_MutH/RE_typeII_Sau3AI

3

IPR011338

11,338

Restriction endonuclease, type II, BamHI/BglIII/BstY

BamHI/BglII/BstY

Homologous_superfamily

595

false

Restriction endonucleases BamHI, BglII, BstYI and OkrAI share a strong structural consensus mapping to the α/β core domain, represented by this superfamily. BamHI recognises the DNA sequence GGATCC and cleaves after G-1 [ ], BglII recognises AGATCT and cleaves after A-1 [ ], BstYI recognises RGATCY and cleaves after th...

[ "GO:0000287", "GO:0003677", "GO:0009036", "GO:0009307" ]

[ "magnesium ion binding", "DNA binding", "type II site-specific deoxyribonuclease activity", "DNA restriction-modification system" ]

[ "molecular_function", "molecular_function", "molecular_function", "biological_process" ]

4

[ "CATHGENE3D" ]

[ "G3DSA:3.40.91.20" ]

[ "" ]

[ 595 ]

1

[ "EC" ]

[ "3.1.21.4" ]

[ "EC:3.1.21.4" ]

1

[ "1bam", "1bhm", "1d2i", "1dfm", "1es8", "1esg", "1sdo", "1vrr", "2bam", "2p0j", "3bam", "3odh" ]

12

[ "PUB00024656", "PUB00028457", "PUB00031005", "PUB00042313", "PUB00110633" ]

[ "10882125", "11175900", "15099740", "17437717", "20833632" ]

[ "Structure of BamHI bound to nonspecific DNA: a model for DNA sliding.", "Structure of free BglII reveals an unprecedented scissor-like motion for opening an endonuclease.", "Crystal structure of BstYI at 1.85A resolution: a thermophilic restriction endonuclease with overlapping specificities to BamHI and BglII...

[ 2000, 2001, 2004, 2007, 2011 ]

5

[]

0

null

[ "Archaea", "Bacteria", "Caudoviricetes", "Opisthokonta", "ecological metagenomes" ]

[ 23, 546, 3, 2, 21 ]

5

[]

0

true

Homologous_superfamily

Restriction endonuclease, type II, BamHI/BglIII/BstY

BamHI/BglII/BstY

6

IPR011339

11,339

Iron-sulfur cluster assembly scaffold protein IscU

ISCU

Family

9,404

false

This entry represents IscU from the ISC system, a homologue of the N-terminal region of NifU (NIF system), an Fe-S cluster assembly protein found mostly in nitrogen-fixing bacteria. IscU is a scaffold protein on which Fe-S clusters are assembled before transfer to apoproteins [ , ]. This family includes largely proteob...

[ "GO:0005506", "GO:0051536", "GO:0016226" ]

[ "iron ion binding", "iron-sulfur cluster binding", "iron-sulfur cluster assembly" ]

[ "molecular_function", "molecular_function", "biological_process" ]

3

[ "NCBIFAM" ]

[ "TIGR01999" ]

[ "iscU" ]

[ 9404 ]

1

[ "GP", "GP", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "GenProp0138", "GenProp1163", "R-DME-1362409", "R-DME-9865881", "R-HSA-1362409", "R-HSA-9694301", "R-HSA-9854311", "R-HSA-9865881", "R-MMU-1362409", "R-MMU-9854311", "R-MMU-9865881", "R-PFA-1362409", "R-SCE-1362409", "R-SCE-9865881", "R-SPO-1362409", "R-SPO-9865881" ]

[ "GP:GenProp0138", "GP:GenProp1163", "REACTOME:R-DME-1362409", "REACTOME:R-DME-9865881", "REACTOME:R-HSA-1362409", "REACTOME:R-HSA-9694301", "REACTOME:R-HSA-9854311", "REACTOME:R-HSA-9865881", "REACTOME:R-MMU-1362409", "REACTOME:R-MMU-9854311", "REACTOME:R-MMU-9865881", "REACTOME:R-PFA-1362409"...

16

[ "1q48", "1r9p", "1wfz", "2kqk", "2l4x", "3lvl", "5kz5", "5t0v", "5tre", "5wkp", "5wlw", "6nzu", "6uxe", "6w1d", "6wi2", "6wih", "7rtk", "8pk8", "8pk9", "8pka", "8rmc", "8rmd", "8rme", "8rmf", "8rmg", "8tvt" ]

26

[ "PUB00003442", "PUB00028014", "PUB00035635", "PUB00035636", "PUB00035637", "PUB00035638", "PUB00035639", "PUB00035640", "PUB00035642", "PUB00101898" ]

[ "8875867", "11498000", "16221578", "16211402", "16843540", "15937904", "17350000", "15278785", "16964969", "34824239" ]

[ "A modular domain of NifU, a nitrogen fixation cluster protein, is highly conserved in evolution.", "Incorporation of iron-sulphur clusters in membrane-bound proteins.", "How Escherichia coli and Saccharomyces cerevisiae build Fe/S proteins.", "Mechanisms of iron-sulfur cluster assembly: the SUF machinery.", ...

[ 1996, 2001, 2005, 2005, 2006, 2005, 2007, 2004, 2006, 2021 ]

10

[]

0

null

[ "Bacteria", "Eukaryota", "Marine Group I thaumarchaeote", "Viruses", "unclassified sequences" ]

[ 4913, 4396, 1, 9, 85 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus",...

[ 10, 1, 4, 1, 1, 5, 2, 1, 4, 3, 2, 1, 9 ]

13

true

Family

Iron-sulfur cluster assembly scaffold protein IscU

ISCU

6

IPR011340

11,340

Cysteine desulfurase-related

Cys_dSase-rel

Family

3,740

false

This entry describes probable pyridoxal phosphate-dependent enzymes in the aminotransferase class V family. The most closely related characterised proteins are active as cysteine desulfurases, selenocysteine lyases, or both; some are involved in FeS cofactor biosynthesis and are designated NifS. An active site Cys resi...

[]

0

[ "NCBIFAM" ]

[ "TIGR01976" ]

[ "am_tr_V_VC1184" ]

[ 3740 ]

1

[]

0

[ "3cai" ]

1

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Methanobacteriati", "metagenomes" ]

[ 3641, 24, 15, 60 ]

4

[]

0

true

Family

Cysteine desulfurase-related

Cys_dSase-rel

9

IPR011342

11,342

Shikimate dehydrogenase

Shikimate_DH

Family

18,678

false

The shikimate pathway links the metabolism of carbohydrates to the biosynthesis of aromatic compounds and is essential for the biosynthesis of aromatic amino acids and other aromatic compounds in bacteria, eukaryotic microorganisms and plants [ ]. It is a seven-step pathway which converts phosphoenolpyruvate and erythr...

[ "GO:0004764", "GO:0050661", "GO:0019632" ]

[ "shikimate 3-dehydrogenase (NADP+) activity", "NADP binding", "shikimate metabolic process" ]

[ "molecular_function", "molecular_function", "biological_process" ]

3

[ "NCBIFAM" ]

[ "TIGR00507" ]

[ "aroE" ]

[ 18678 ]

1

[ "EC", "GP", "GP", "GP", "METACYC" ]

[ "1.1.1.25", "GenProp0001", "GenProp1478", "GenProp1643", "PWY-6163" ]

[ "EC:1.1.1.25", "GP:GenProp0001", "GP:GenProp1478", "GP:GenProp1643", "METACYC:PWY-6163" ]

5

[ "1nvt", "1nyt", "1p74", "1p77", "1wxd", "2cy0", "2d5c", "2egg", "2ev9", "2gpt", "2hk7", "2hk8", "2hk9", "2o7q", "2o7s", "3don", "3doo", "3fbt", "3o8q", "3pgj", "3phg", "3phh", "3phi", "3phj", "3pwz", "3sef", "3tnl", "3toz", "4foo", "4fos", "4fpx", "4fq8"...

40

[ "PUB00014334", "PUB00028041", "PUB00028042", "PUB00028043" ]

[ "15012217", "3883995", "12906831", "12837789" ]

[ "THE SHIKIMATE PATHWAY.", "The purification of shikimate dehydrogenase from Escherichia coli.", "Crystal structure of shikimate 5-dehydrogenase (SDH) bound to NADP: insights into function and evolution.", "The crystal structure of shikimate dehydrogenase (AroE) reveals a unique NADPH binding mode." ]

[ 1999, 1985, 2003, 2003 ]

4

[ "IPR022893" ]

[]

1

0

1

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 712, 16955, 718, 293 ]

4

[ "Arabidopsis thaliana", "Escherichia coli (strain K12)", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 4, 1, 2, 13 ]

4

true

Family

Shikimate dehydrogenase

Shikimate_DH

8

IPR011343

11,343

Deoxyribose-phosphate aldolase

DeoC

Family

25,130

false

Aldolases play important roles in essential metabolic pathways, such as gluconeogenesis and glycolysis. They are classified with respect to their catalytic mechanism into two classes: class I adolases are are characterised by formation of covalent Schiff base intermediates, while class II aldolases are metallodependent...

[ "GO:0004139", "GO:0009264", "GO:0005737" ]

[ "deoxyribose-phosphate aldolase activity", "deoxyribonucleotide catabolic process", "cytoplasm" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PIRSF", "PANTHER", "NCBIFAM", "CDD" ]

[ "PIRSF001357", "PTHR10889", "TIGR00126", "cd00959" ]

[ "DeoC", "", "deoC", "DeoC" ]

[ 20123, 25042, 24054, 22442 ]

4

[ "EC", "GP", "METACYC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "4.1.2.4", "GenProp1559", "PWY-7180", "PWY-8060", "R-BTA-6798695", "R-BTA-71336", "R-CEL-6798695", "R-CEL-71336", "R-HSA-6798695", "R-HSA-71336", "R-MMU-6798695", "R-MMU-71336" ]

[ "EC:4.1.2.4", "GP:GenProp1559", "METACYC:PWY-7180", "METACYC:PWY-8060", "REACTOME:R-BTA-6798695", "REACTOME:R-BTA-71336", "REACTOME:R-CEL-6798695", "REACTOME:R-CEL-71336", "REACTOME:R-HSA-6798695", "REACTOME:R-HSA-71336", "REACTOME:R-MMU-6798695", "REACTOME:R-MMU-71336" ]

12

[ "1j2w", "1jcj", "1jcl", "1ktn", "1mzh", "1n7k", "1p1x", "1ub3", "1vcv", "2a4a", "3ndo", "3ng3", "3ngj", "3npu", "3npv", "3npw", "3npx", "3nq2", "3nq8", "3nqv", "3nr0", "3oa3", "3q2d", "3qyq", "3r12", "3r13", "4eiv", "4xbk", "4xbs", "5c2x", "5c5y", "5c6m"...

51

[ "PUB00000628", "PUB00016149", "PUB00021873", "PUB00027586", "PUB00028044", "PUB00040690", "PUB00060480", "PUB00060481", "PUB00060482", "PUB00060483", "PUB00080613", "PUB00153747" ]

[ "1730028", "11598300", "15388928", "12529358", "4923156", "16843441", "13950007", "5972827", "5793710", "5816380", "12467706", "25284756" ]

[ "Deoxyribose 5-phosphate aldolase of Bacillus cereus: purification and properties.", "Observation of covalent intermediates in an enzyme mechanism at atomic resolution.", "Structure of aldolase from Thermus thermophilus HB8 showing the contribution of oligomeric state to thermostability.", "The first crystal ...

[ 1992, 2001, 2004, 2003, 1970, 2006, 1962, 1966, 1969, 1969, 2003, 2015 ]

12

[ "IPR002915" ]

[ "IPR023649", "IPR028581" ]

1

2

0

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences", "uncultured marine phage" ]

[ 532, 20387, 3789, 421, 1 ]

5

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus" ]

[ 1, 1, 2, 1, 7, 6, 1, 6 ]

8

true

Family

Deoxyribose-phosphate aldolase

DeoC

6

IPR011344

11,344

Single-stranded DNA-binding protein

ssDNA-bd

Family

53,697

false

Single-stranded DNA-binding protein (SSB) plays an important role in DNA replication, recombination and repair. It binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism [ , , , ].

[ "GO:0003697", "GO:0006260" ]

[ "single-stranded DNA binding", "DNA replication" ]

[ "molecular_function", "biological_process" ]

2

[ "HAMAP", "PIRSF", "PANTHER", "NCBIFAM" ]

[ "MF_00984", "PIRSF002070", "PTHR10302", "TIGR00621" ]

[ "SSB", "SSB", "", "ssb" ]

[ 41533, 28426, 47794, 46896 ]

4

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-CEL-9837999", "R-CEL-9913635", "R-DME-9837999", "R-DME-9913635", "R-HSA-2151201", "R-HSA-9837999", "R-HSA-9913635", "R-MMU-9837999", "R-MMU-9913635", "R-RNO-9837999", "R-RNO-9913635", "R-SCE-9837999" ]

[ "REACTOME:R-CEL-9837999", "REACTOME:R-CEL-9913635", "REACTOME:R-DME-9837999", "REACTOME:R-DME-9913635", "REACTOME:R-HSA-2151201", "REACTOME:R-HSA-9837999", "REACTOME:R-HSA-9913635", "REACTOME:R-MMU-9837999", "REACTOME:R-MMU-9913635", "REACTOME:R-RNO-9837999", "REACTOME:R-RNO-9913635", "REACTOM...

12

[ "1eqq", "1eyg", "1kaw", "1qvc", "1s3o", "1se8", "1sru", "1ue1", "1ue5", "1ue6", "1ue7", "1x3e", "1x3f", "1x3g", "1z9f", "2cwa", "2dud", "2fxq", "2ihe", "2ihf", "2vw9", "3a5u", "3afp", "3afq", "3eiv", "3lgj", "3pgz", "3tqy", "3udg", "3ull", "3ulp", "3vdy"...

59

[ "PUB00074161", "PUB00074162", "PUB00074163", "PUB00094198" ]

[ "18937104", "20360609", "21784244", "27519413" ]

[ "SSB as an organizer/mobilizer of genome maintenance complexes.", "Regulation of single-stranded DNA binding by the C termini of Escherichia coli single-stranded DNA-binding (SSB) protein.", "SSB functions as a sliding platform that migrates on DNA via reptation.", "Escherichia coli RadD Protein Functionally ...

[ 2008, 2010, 2011, 2016 ]

4

[ "IPR000424" ]

[]

1

0

1

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "plasmids", "unclassified sequences" ]

[ 3, 45753, 6091, 1086, 9, 755 ]

6

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus",...

[ 25, 1, 1, 1, 2, 7, 3, 1, 18, 7, 1, 35 ]

12

true

Family

Single-stranded DNA-binding protein

ssDNA-bd

9

IPR011346

11,346

High-molecular-weight cytochrome c

Cyt_cc3

Family

9

false

Cytochromes c (cytC) can be defined as electron-transfer proteins having one or several haem c groups, bound to the protein by one or, more generally, two thioether bonds involving sulphydryl groups of cysteine residues. The fifth haem iron ligand is always provided by a histidine residue. CytC possess a wide range of ...

[]

0

[ "PIRSF" ]

[ "PIRSF000026" ]

[ "Cytochrome_cc3" ]

[ 9 ]

1

[]

0

[ "1gws", "1h29", "2cvc", "2e84" ]

4

[ "PUB00021717", "PUB00025401", "PUB00028007", "PUB00028008" ]

[ "12356749", "12467575", "11041344", "10606770" ]

[ "Sulfate respiration in Desulfovibrio vulgaris Hildenborough. Structure of the 16-heme cytochrome c HmcA AT 2.5-A resolution and a view of its role in transmembrane electron transfer.", "The crystal structure of the hexadeca-heme cytochrome Hmc and a structural model of its complex with cytochrome c(3).", "Dele...

[ 2002, 2002, 2000, 2000 ]

4

[ "IPR054813" ]

[]

1

0

1

[ "Desulfovibrionaceae" ]

[ 9 ]

1

[]

0

true

Family

High-molecular-weight cytochrome c

Cyt_cc3

4

IPR011348

11,348

17beta-dehydrogenase

17beta_DH

Family

1,768

false

This entry represents 17beta-hydroxysteroid dehydrogenases (17B-HSDs), a group of enzymes which catalyse the last step in the biosynthesis of all androgens and estrogens -the reversible NAD(P)-linked transfer of a hydride to and from the 17-position of steroid molecules [ ]. A total of six isozymes have been identified...

[ "GO:0004303", "GO:0006703", "GO:0005737" ]

[ "estradiol 17-beta-dehydrogenase [NAD(P)+] activity", "estrogen biosynthetic process", "cytoplasm" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PIRSF" ]

[ "PIRSF000095" ]

[ "17beta-HSD" ]

[ 1768 ]

1

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "1.1.1.62", "R-HSA-193144", "R-HSA-2453902", "R-MMU-193144", "R-RNO-193144" ]

[ "EC:1.1.1.62", "REACTOME:R-HSA-193144", "REACTOME:R-HSA-2453902", "REACTOME:R-MMU-193144", "REACTOME:R-RNO-193144" ]

5

[ "1a27", "1bhs", "1dht", "1equ", "1fds", "1fdt", "1fdu", "1fdv", "1fdw", "1i5r", "1iol", "1jtv", "1qyv", "1qyw", "1qyx", "3dey", "3dhe", "3hb4", "3hb5", "3klm", "3klp", "3km0", "6cgc", "6cge", "6dtp", "6mnc", "6mne", "7x3z" ]

28

[ "PUB00023623", "PUB00024639", "PUB00028053", "PUB00095624" ]

[ "7663947", "9927655", "8943783", "10753906" ]

[ "Structure of human estrogenic 17 beta-hydroxysteroid dehydrogenase at 2.20 A resolution.", "Structure of the ternary complex of human 17beta-hydroxysteroid dehydrogenase type 1 with 3-hydroxyestra-1,3,5,7-tetraen-17-one (equilin) and NADP+.", "Expression and regulation of 17 beta-hydroxysteroid dehydrogenase t...

[ 1995, 1999, 1996, 2000 ]

4

[ "IPR002347" ]

[]

1

0

1

[ "Staphylococcus haemolyticus", "Vertebrata" ]

[ 2, 1766 ]

2

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 6, 5, 4, 4 ]

4

true

Family

17beta-dehydrogenase

17beta_DH

9

IPR011356

11,356

Peptidase M17, leucine aminopeptidase/peptidase B

Leucine_aapep/pepB

Family

38,870

false

The majority of members of this family are zinc-dependent exopeptidases belonging to MEROPS peptidase family M17 (leucyl aminopeptidase, clan MF). Leucyl aminopeptidase (LAP; ) selectively release N-terminal amino acid residues from polypeptides and proteins; in general they are involved in the processing, catabolism a...

[ "GO:0030145", "GO:0070006", "GO:0019538", "GO:0005737" ]

[ "manganese ion binding", "metalloaminopeptidase activity", "protein metabolic process", "cytoplasm" ]

[ "molecular_function", "molecular_function", "biological_process", "cellular_component" ]

4

[ "PRINTS", "PANTHER", "CDD" ]

[ "PR00481", "PTHR11963", "cd00433" ]

[ "LAMNOPPTDASE", "", "Peptidase_M17" ]

[ 37755, 38779, 35001 ]

3

[ "EC", "EC", "EC" ]

[ "3.4.11", "3.4.11.1", "3.4.11.10" ]

[ "EC:3.4.11", "EC:3.4.11.1", "EC:3.4.11.10" ]

3

[ "1bll", "1bpm", "1bpn", "1gyt", "1lam", "1lan", "1lap", "1lcp", "2ewb", "2hb6", "2hc9", "2j9a", "3h8e", "3h8f", "3h8g", "3ij3", "3jru", "3kqx", "3kqz", "3kr4", "3kr5", "3kzw", "3pei", "3t8w", "4efd", "4k3n", "4ksi", "4r6t", "4r76", "4r7m", "4x2t", "4zi6"...

69

[ "PUB00000202", "PUB00000522", "PUB00001416", "PUB00003579", "PUB00004713", "PUB00011211", "PUB00011212", "PUB00011213", "PUB00011215", "PUB00014575" ]

[ "1908238", "8439290", "1555602", "7674922", "2395881", "8703509", "10449417", "10970742", "8506345", "2670557" ]

[ "Structural and immunological evidence for the identity of prolyl aminopeptidase with leucyl aminopeptidase.", "Evolutionary families of peptidases.", "Leucine aminopeptidase from Arabidopsis thaliana. Molecular evidence for a phylogenetically conserved enzyme of protein turnover in higher plants.", "Evolutio...

[ 1991, 1993, 1992, 1995, 1990, 1996, 1999, 2000, 1993, 1989 ]

10

[]

[ "IPR008330", "IPR023042" ]

0

2

0

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 85, 28757, 9280, 3, 745 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)", "Zea mays" ]

[ 16, 2, 5, 14, 2, 7, 8, 3, 7, 1, 26 ]

11

true

Family

Peptidase M17, leucine aminopeptidase/peptidase B

Leucine_aapep/pepB

5

IPR011363

11,363

Dorsal-related immunity factor Dif

Dif

Family

173

false

The Dorsal morphogen directs formation of the Drosophila dorsoventral axis by both activating and repressing transcription. It contains an N-terminal Rel homology domain (RHD), which is responsible for DNA binding and regulated nuclear import, and a C-terminal domain (CTD) that contains activation and repression motifs...

[ "GO:0003700", "GO:0006357", "GO:0005634", "GO:0005737" ]

[ "DNA-binding transcription factor activity", "regulation of transcription by RNA polymerase II", "nucleus", "cytoplasm" ]

[ "molecular_function", "biological_process", "cellular_component", "cellular_component" ]

4

[ "PIRSF" ]

[ "PIRSF001716" ]

[ "Dorsal" ]

[ 173 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-DME-1169091", "R-DME-1810476", "R-DME-202424", "R-DME-209400", "R-DME-209406", "R-DME-209560", "R-DME-214842", "R-DME-214844", "R-DME-214869", "R-DME-2871837", "R-DME-3134963", "R-DME-445989", "R-DME-4755510", "R-DME-5607764", "R-DME-5621575", "R-DME-9020702", "R-DME-933542", "R...

[ "REACTOME:R-DME-1169091", "REACTOME:R-DME-1810476", "REACTOME:R-DME-202424", "REACTOME:R-DME-209400", "REACTOME:R-DME-209406", "REACTOME:R-DME-209560", "REACTOME:R-DME-214842", "REACTOME:R-DME-214844", "REACTOME:R-DME-214869", "REACTOME:R-DME-2871837", "REACTOME:R-DME-3134963", "REACTOME:R-DME...

18

[]

0

[ "PUB00014581", "PUB00014582", "PUB00073044" ]

[ "12077338", "3118464", "8242747" ]

[ "The Dorsal Rel homology domain plays an active role in transcriptional regulation.", "Dorsal, an embryonic polarity gene in Drosophila, is homologous to the vertebrate proto-oncogene, c-rel.", "Dif, a dorsal-related gene that mediates an immune response in Drosophila." ]

[ 2002, 1987, 1993 ]

3

[ "IPR000451" ]

[]

1

0

1

[ "Bilateria" ]

[ 173 ]

1

[ "Drosophila melanogaster" ]

[ 3 ]

1

true

Family

Dorsal-related immunity factor Dif

Dif

7

IPR011364

11,364

Breast cancer type 1 susceptibility protein (BRCA1)

BRCA1

Family

1,233

false

Breast cancer is a common malignancy, affecting 1 in 8 women. A major contributary factor in disease development lies in a positive family history, a correlation that is striking for early-onset breast cancer. Mutations in the DNA-damage repair protein BRCA1 [ , ] are believed to be responsible for 45% of inherited bre...

[ "GO:0003677", "GO:0004842", "GO:0008270", "GO:0006281", "GO:0005634" ]

[ "DNA binding", "ubiquitin-protein transferase activity", "zinc ion binding", "DNA repair", "nucleus" ]

[ "molecular_function", "molecular_function", "molecular_function", "biological_process", "cellular_component" ]

5

[ "PRINTS" ]

[ "PR00493" ]

[ "BRSTCANCERI" ]

[ 1233 ]

1

[ "EC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "...

[ "2.3.2.27", "PWY-7511", "R-HSA-1221632", "R-HSA-3108214", "R-HSA-5685938", "R-HSA-5685942", "R-HSA-5689901", "R-HSA-5693554", "R-HSA-5693565", "R-HSA-5693568", "R-HSA-5693571", "R-HSA-5693579", "R-HSA-5693607", "R-HSA-5693616", "R-HSA-6796648", "R-HSA-6804756", "R-HSA-69473", "R-HS...

[ "EC:2.3.2.27", "METACYC:PWY-7511", "REACTOME:R-HSA-1221632", "REACTOME:R-HSA-3108214", "REACTOME:R-HSA-5685938", "REACTOME:R-HSA-5685942", "REACTOME:R-HSA-5689901", "REACTOME:R-HSA-5693554", "REACTOME:R-HSA-5693565", "REACTOME:R-HSA-5693568", "REACTOME:R-HSA-5693571", "REACTOME:R-HSA-5693579",...

53

[ "1jnx", "1l0b", "1n5o", "1t15", "1t29", "1t2u", "1t2v", "1y98", "2ing", "3coj", "3k0h", "3k0k", "3k15", "3k16", "3pxa", "3pxb", "3pxc", "3pxd", "3pxe", "4ifi", "4igk", "4jlu", "4ofb", "4u4a", "4y18", "4y2g", "6g2i", "8rs8" ]

28

[ "PUB00014583", "PUB00014584", "PUB00014805", "PUB00017952", "PUB00066908" ]

[ "10198641", "8232556", "14576433", "10500182", "10724175" ]

[ "Centrosome amplification and a defective G2-M cell cycle checkpoint induce genetic instability in BRCA1 exon 11 isoform-deficient cells.", "BRG1 contains a conserved domain of the SWI2/SNF2 family necessary for normal mitotic growth and transcription.", "The BRCT domain is a phospho-protein binding domain.", ...

[ 1999, 1993, 2003, 1999, 2000 ]

5

[ "IPR031099" ]

[]

1

0

1

[ "Eumetazoa" ]

[ 1233 ]

1

[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 53, 28, 7 ]

3

true

Family

Breast cancer type 1 susceptibility protein (BRCA1)

BRCA1

3

IPR011365

11,365

Cytokine IL-3/IL-5/GM-CSF receptor common beta chain

IL3_rcpt_beta

Family

27

false

This group represents a cytokine IL-3/IL-5/GM-CSF receptor common beta chain. Please see the following relevant reference: [ ].

[ "GO:0004896", "GO:0019221", "GO:0016020" ]

[ "cytokine receptor activity", "cytokine-mediated signaling pathway", "membrane" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PIRSF" ]

[ "PIRSF001956" ]

[ "IL3R_beta_c" ]

[ 27 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-512988", "R-HSA-5673001", "R-HSA-5683826", "R-HSA-5688849", "R-HSA-5688890", "R-HSA-912526", "R-MMU-512988", "R-MMU-5673001", "R-MMU-912526" ]

[ "REACTOME:R-HSA-512988", "REACTOME:R-HSA-5673001", "REACTOME:R-HSA-5683826", "REACTOME:R-HSA-5688849", "REACTOME:R-HSA-5688890", "REACTOME:R-HSA-912526", "REACTOME:R-MMU-512988", "REACTOME:R-MMU-5673001", "REACTOME:R-MMU-912526" ]

9

[]

0

[ "PUB00014585" ]

[ "9794243" ]

[ "Regulation of proliferation, differentiation and survival by the IL-3/IL-5/GM-CSF receptor family." ]

[ 1998 ]

1

[]

0

null

[ "Euarchontoglires" ]

[ 27 ]

1

[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 7, 3 ]

3

true

Family

Cytokine IL-3/IL-5/GM-CSF receptor common beta chain

IL3_rcpt_beta

8

IPR011375

11,375

MfnE family

MfnE

Family

228

false

This family includes the MJ0458 protein from Methanocaldococcus jannaschii (Methanococcus jannaschii), which was predicted to be related to aspartokinase and uridylate kinase [ ]. MJ0458 has been characterised and renamed as MfnE. It functions as a 5-(aminomethyl)-3-furanmethanol phosphate kinase in the methanofuran bi...

[]

0

[ "PIRSF", "CDD" ]

[ "PIRSF004857", "cd04240" ]

[ "Kin_aa_kin", "AAK_UC" ]

[ 219, 114 ]

2

[]

0

[ "7qrh" ]

1

[ "PUB00077118", "PUB00077119" ]

[ "26100040", "22002406" ]

[ "Identification of the Final Two Genes Functioning in Methanofuran Biosynthesis in Methanocaldococcus jannaschii.", "A new class of adenylate kinase in methanogens is related to uridylate kinase." ]

[ 2015, 2012 ]

2

[]

0

null

[ "Archaea", "Pseudomonadati", "groundwater metagenome" ]

[ 208, 19, 1 ]

3

[]

0

true

Family

MfnE family

MfnE

6

IPR011379

11,379

NTP Pyrophosphohydrolase MazG-related, GP37

MazG-related_GP37

Family

2,105

false

Members of this group are distantly related to MazG-type NTP pyrophosphohydrolase. Conserved residues of the MazG domain (at least three of the Glu residues, Asp, Lys and Arg), which include those shown to be functionally important [ ], are also conserved here. MazG protein of Thermotoga maritima has been shown to have...

[]

0

[ "PIRSF", "CDD" ]

[ "PIRSF006639", "cd11541" ]

[ "UCP006639_pph", "NTP-PPase_u4" ]

[ 1387, 2058 ]

2

[]

0

[]

0

[ "PUB00013554", "PUB00014610" ]

[ "12657645", "12218018" ]

[ "Thermotoga maritima MazG protein has both nucleoside triphosphate pyrophosphohydrolase and pyrophosphatase activities.", "MazG, a nucleoside triphosphate pyrophosphohydrolase, interacts with Era, an essential GTPase in Escherichia coli." ]

[ 2003, 2002 ]

2

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "metagenomes" ]

[ 7, 1704, 5, 345, 44 ]

5

[]

0

true

Family

NTP Pyrophosphohydrolase MazG-related, GP37

MazG-related_GP37

5

IPR011381

11,381

Histone-lysine N-methyltransferase SUV39H1/2-like

H3-K9_MeTrfase_SUV39H1/2-like

Family

2,059

false

Members of this family trimethylate 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate, including histone-lysine N-methyltransferase Su(var)3-9 from Drosophila melanogaster and its orthologue from human, SUV39H1. SUV39H1 also weakly methylates histone H1 (in vitro). H3 'Lys-9' trimethylation represents ...

[ "GO:0046974", "GO:0005634" ]

[ "histone H3K9 methyltransferase activity", "nucleus" ]

[ "molecular_function", "cellular_component" ]

2

[ "PIRSF", "PROFILE" ]

[ "PIRSF009343", "PS51579" ]

[ "SUV39_SET", "SAM_MT43_SUVAR39_3" ]

[ 2004, 1364 ]

2

[ "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC"...

[ "2.1.1.-", "PWY-1061", "PWY-2083", "PWY-3542", "PWY-4021", "PWY-4161", "PWY-4202", "PWY-5059", "PWY-5105", "PWY-5301", "PWY-5305", "PWY-5479", "PWY-5665", "PWY-5729", "PWY-5748", "PWY-5765", "PWY-5773", "PWY-5846", "PWY-5883", "PWY-5975", "PWY-5987", "PWY-601", "PWY-6045"...

[ "EC:2.1.1.-", "METACYC:PWY-1061", "METACYC:PWY-2083", "METACYC:PWY-3542", "METACYC:PWY-4021", "METACYC:PWY-4161", "METACYC:PWY-4202", "METACYC:PWY-5059", "METACYC:PWY-5105", "METACYC:PWY-5301", "METACYC:PWY-5305", "METACYC:PWY-5479", "METACYC:PWY-5665", "METACYC:PWY-5729", "METACYC:PWY-5...

150

[ "1mvh", "1mvx", "2r3a", "6box", "6bp4", "6p0r", "6z2a", "9isz", "9it4" ]

9

[ "PUB00006319", "PUB00007132", "PUB00014403", "PUB00014448", "PUB00014462", "PUB00050320", "PUB00054125", "PUB00057957", "PUB00057958", "PUB00058070", "PUB00058071", "PUB00058072", "PUB00058073", "PUB00058074", "PUB00058077", "PUB00058078", "PUB00058079", "PUB00058080" ]

[ "7897657", "12039029", "10202156", "10949293", "10848615", "18485871", "12826405", "16225687", "21858014", "14690609", "14690610", "14702045", "14765126", "11701123", "16858404", "16449642", "16818776", "18004385" ]

[ "Universal catalytic domain structure of AdoMet-dependent methyltransferases.", "SET-domain proteins of the Su(var)3-9, E(z) and trithorax families.", "Functional mammalian homologues of the Drosophila PEV-modifier Su(var)3-9 encode centromere-associated proteins which complex with the heterochromatin component...

[ 1995, 2002, 1999, 2000, 2000, 2008, 2003, 2005, 2011, 2003, 2003, 2004, 2004, 2001, 2006, 2006, 2006, 2007 ]

18

[]

0

null

[ "Opisthokonta" ]

[ 2059 ]

1

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 4, 3, 5, 7, 12, 1 ]

6

true

Family

Histone-lysine N-methyltransferase SUV39H1/2-like

H3-K9_MeTrfase_SUV39H1/2-like

2

IPR011385

11,385

Putative site-specific recombinase Gcr

Site-sp_rcmbase

Family

2,177

false

This group represents a putative site-specific recombinase Gcr [ ].

[]

0

[ "PFAM", "PIRSF" ]

[ "PF10136", "PIRSF015380" ]

[ "SpecificRecomb", "Site-sp_rcmb" ]

[ 2177, 1652 ]

2

[]

0

[]

0

[ "PUB00014618" ]

[ "9079926" ]

[ "Inversion of Moraxella lacunata type 4 pilin gene sequences by a Neisseria gonorrhoeae site-specific recombinase." ]

[ 1997 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "ecological metagenomes" ]

[ 2164, 4, 9 ]

3

[]

0

true

Family

Putative site-specific recombinase Gcr

Site-sp_rcmbase

9

IPR011386

11,386

Putative ATP-NAD kinase

Put_ATP-NAD_kin

Family

1,639

false

Members of this group are predicted to be kinases (possibly ATP-NAD kinases, ) on the basis of distant sequence similarity.

[]

0

[ "PIRSF" ]

[ "PIRSF016907" ]

[ "Kin_ATP-NAD" ]

[ 1639 ]

1

[]

0

[]

0

[]

0

[ "IPR039065" ]

[]

1

0

1

[ "Archaea", "Bacteria", "ecological metagenomes" ]

[ 536, 1083, 20 ]

3

[]

0

true

Family

Putative ATP-NAD kinase

Put_ATP-NAD_kin

2

IPR011388

11,388

Sphingolipid delta4-desaturase

DES1/DES2

Family

4,776

false

This group represents sphingolipid delta-4 desaturase (DEGS), an integral membrane protein required for sphingosine biosynthesis. It converts D-erythro-sphinganine to D-erythro-sphingosine (E-sphing-4-enine) [ ]. Delta4-desaturated sphingolipids provide an early signal that triggers the entry into both meiotic and sper...

[ "GO:0042284", "GO:0030148", "GO:0016020" ]

[ "sphingolipid delta-4 desaturase activity", "sphingolipid biosynthetic process", "membrane" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PIRSF", "CDD" ]

[ "PIRSF017228", "cd03508" ]

[ "Sphnglp_dlt4_des", "Delta4-sphingolipid-FADS-like" ]

[ 4169, 4700 ]

2

[ "EC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "1.14.19.17", "PWY-5129", "R-BTA-1660661", "R-BTA-6798695", "R-CEL-1660661", "R-CEL-6798695", "R-DME-1660661", "R-DME-6798695", "R-GGA-1660661", "R-GGA-433584", "R-GGA-6798695", "R-HSA-1660661", "R-HSA-6798695", "R-MMU-1660661", "R-MMU-6798695", "R-RNO-1660661", "R-RNO-6798695", "R...

[ "EC:1.14.19.17", "METACYC:PWY-5129", "REACTOME:R-BTA-1660661", "REACTOME:R-BTA-6798695", "REACTOME:R-CEL-1660661", "REACTOME:R-CEL-6798695", "REACTOME:R-DME-1660661", "REACTOME:R-DME-6798695", "REACTOME:R-GGA-1660661", "REACTOME:R-GGA-433584", "REACTOME:R-GGA-6798695", "REACTOME:R-HSA-1660661"...

21

[]

0

[ "PUB00014620" ]

[ "11937514" ]

[ "Identification and characterization of a sphingolipid delta 4-desaturase family." ]

[ 2002 ]

1

[]

0

null

[ "Emiliania huxleyi virus 86 (isolate United Kingdom/English Channel/1999)", "Eukaryota", "Pseudomonadati", "viral metagenome" ]

[ 1, 4763, 11, 1 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Schizosaccharomyces pombe (stra...

[ 4, 2, 2, 1, 3, 4, 1, 1, 6, 1, 2 ]

11

true

Family

Sphingolipid delta4-desaturase

DES1/DES2

4

IPR011390

11,390

Insulin-like growth factor binding protein-related protein (IGFBP-rP), MAC25

IGFBP_rP_mac25

Family

3,852

false

Insulin is found in many animals, and is involved in the regulation of normal glucose homeostasis. It also has other specific physiological effects, such as increasing the permeability of cells to monosaccharides, amino acids and fatty acids, and accelerating glycolysis and glycogen synthesis in the liver [ ]. Insulin ...

[ "GO:0005520", "GO:0001558", "GO:0005576" ]

[ "insulin-like growth factor binding", "regulation of cell growth", "extracellular region" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PIRSF", "PANTHER" ]

[ "PIRSF018239", "PTHR14186" ]

[ "IGFBP_rP_mac25", "" ]

[ 1406, 3852 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-2559582", "R-HSA-381426", "R-HSA-8957275", "R-MMU-381426", "R-MMU-8957275" ]

[ "REACTOME:R-HSA-2559582", "REACTOME:R-HSA-381426", "REACTOME:R-HSA-8957275", "REACTOME:R-MMU-381426", "REACTOME:R-MMU-8957275" ]

5

[ "3tjq", "3zxb" ]

2

[ "PUB00003970", "PUB00003972", "PUB00003973", "PUB00013535", "PUB00013536", "PUB00013537", "PUB00013538", "PUB00013539", "PUB00013540", "PUB00013541", "PUB00013542", "PUB00014624", "PUB00023078", "PUB00037375", "PUB00053639", "PUB00053640", "PUB00053641", "PUB00053642" ]

[ "503234", "6243748", "6107857", "11874691", "9822601", "9725901", "7519375", "9660801", "12379487", "12379489", "7504269", "9745429", "2036417", "9141131", "10601981", "8735594", "8683595", "1319992" ]

[ "Nucleotide sequence of a cDNA clone encoding human preproinsulin.", "Sequence of the human insulin gene.", "Hormone families: pancreatic hormones and homologous growth factors.", "IGF-binding protein-5: flexible player in the IGF system and effector on its own.", "Structure of the IGF-binding domain of the...

[ 1979, 1980, 1980, 2002, 1998, 1998, 1994, 1998, 2002, 2002, 1993, 1998, 1991, 1997, 1999, 1996, 1996, 1992 ]

18

[]

0

null

[ "Metazoa" ]

[ 3852 ]

1

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 8, 1, 6, 10, 10 ]

5

true

Family

Insulin-like growth factor binding protein-related protein (IGFBP-rP), MAC25

IGFBP_rP_mac25

7

IPR011391

11,391

Acetoin catabolism kinase AcoX

AcoX_kinase

Family

835

false

Members of this group are involved in acetoin catabolism [ , , ] and are encoded in the aco operon. They are predicted to be kinases (possibly ATP-NAD kinases, ) on the basis of distant sequence similarity.

[]

0

[ "PIRSF" ]

[ "PIRSF018567" ]

[ "AcoX" ]

[ 835 ]

1

[]

0

[]

0

[ "PUB00002145", "PUB00014625", "PUB00014626" ]

[ "2061286", "7813883", "8206840" ]

[ "Identification and molecular characterization of the Alcaligenes eutrophus H16 aco operon genes involved in acetoin catabolism.", "Molecular characterization of the Pseudomonas putida 2,3-butanediol catabolic pathway.", "Biochemical and molecular characterization of the Clostridium magnum acetoin dehydrogenase...

[ 1991, 1994, 1994 ]

3

[ "IPR039065" ]

[]

1

0

1

[ "Archaea", "Bacteria", "Geodia barretti", "ecological metagenomes" ]

[ 26, 797, 2, 10 ]

4

[]

0

true

Family

Acetoin catabolism kinase AcoX

AcoX_kinase

7

IPR011392

11,392

Tellurite resistance, TerY

Tellurite-R_TerY

Family

2,114

false

This group represents a phage/colicin/tellurite resistance cluster protein, TerY type.

[]

0

[ "PIRSF" ]

[ "PIRSF020634" ]

[ "TerY_vWA" ]

[ 2114 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Geodia barretti", "Methanomicrobiales", "Plasmid R478", "metagenomes" ]

[ 2086, 2, 15, 1, 10 ]

5

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Tellurite resistance, TerY

Tellurite-R_TerY

4

IPR011395

11,395

Alpha glucuronidase

Glyco_hydro_67_aGlcAse

Family

2,707

false

Alpha-glucuronidases belong to an ensemble of enzymes, which are central to the recycling of photosynthetic biomass. To date, all of the alpha-glucuronidases are classified as family 67 glycosidases, which catalyze the hydrolysis via the investing mechanism [ ]. They hydrolyze the alpha1,2-glycosidic bond between 4-O-m...

[ "GO:0046559", "GO:0045493", "GO:0005576" ]

[ "alpha-glucuronidase activity", "xylan catabolic process", "extracellular region" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PIRSF" ]

[ "PIRSF029900" ]

[ "Alpha-glucuronds" ]

[ 2707 ]

1

[ "EC" ]

[ "3.2.1.139" ]

[ "EC:3.2.1.139" ]

1

[ "1gqi", "1gqj", "1gqk", "1gql", "1h41", "1k9d", "1k9e", "1k9f", "1l8n", "1mqp", "1mqq", "1mqr" ]

12

[ "PUB00014285", "PUB00026672", "PUB00028600" ]

[ "11937059", "14573597", "12654910" ]

[ "The structural basis for catalysis and specificity of the Pseudomonas cellulosa alpha-glucuronidase, GlcA67A.", "Crystal structures of Geobacillus stearothermophilus alpha-glucuronidase complexed with its substrate and products: mechanistic implications.", "The alpha-glucuronidase, GlcA67A, of Cellvibrio japon...

[ 2002, 2004, 2003 ]

3

[]

0

null

[ "Bacteria", "Opisthokonta", "unclassified sequences" ]

[ 1923, 779, 5 ]

3

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)" ]

[ 1 ]

1

true

Family

Alpha glucuronidase

Glyco_hydro_67_aGlcAse

5

IPR011396

11,396

Phosphorothioated DNA-binding restriction endonuclease

PT_DNA_restrict

Family

1,746

false

This entry represents a group of proteins from bacteria that are distantly related to the C-terminal half of the type IV restriction endonuclease McrA from Streptomyces coelicolor ( ), which can act on phosphorothioated DNA (PT-DNA), as do members of this family. This family was previously known as UCP030850.

[]

0

[ "NCBIFAM", "PIRSF" ]

[ "NF045808", "PIRSF030850" ]

[ "PT-DNA_restrict", "UCP030850" ]

[ 1353, 1660 ]

2

[]

0

[]

0

[ "PUB00154747" ]

[ "30409991" ]

[ "Structural basis for the recognition of sulfur in phosphorothioated DNA." ]

[ 2018 ]

1

[]

0

null

[ "Bacteria", "Candidatus Methanogaster sp. ANME-2c ERB4", "Caudovirales sp. ctilw2", "metagenomes" ]

[ 1735, 1, 1, 9 ]

4

[]

0

true

Family

Phosphorothioated DNA-binding restriction endonuclease

PT_DNA_restrict

5

IPR011397

11,397

Intramembrane metalloprotease YhfC

YhfC

Family

1,723

false

This family includes proteins that are mainly from Firmicutes and Proteobacteria. Family members bear the consensus signature of -EExxR- the second motif -HxxxE- and the third motif -H/Qxxxs-. The fourth motif, -HxxxB-, is shared by the PrsW proteases ( ) and the CPBP ( ), and APH-1 families. There are currently no exp...

[]

0

[ "PFAM", "PIRSF" ]

[ "PF10086", "PIRSF033101" ]

[ "YhfC", "UCP033101" ]

[ 1723, 1383 ]

2

[]

0

[]

0

[ "PUB00091031" ]

[ "21570408" ]

[ "Expansion of type II CAAX proteases reveals evolutionary origin of γ-secretase subunit APH-1." ]

[ 2011 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Sar", "metagenomes" ]

[ 53, 1646, 4, 20 ]

4

[]

0

true

Family

Intramembrane metalloprotease YhfC

YhfC

2

IPR011399

11,399

Nitrous oxide reductase expression regulator NosR

NosR

Family

1,845

false

The bacterial protein NosR is involved in N 2 O respiration. It is a membrane bound iron-sulphur flavoprotein that is required for the transcription of nosZ genes and also for cellular activity of its homologue, NosZ [ ].

[ "GO:0003677", "GO:0045893", "GO:0016020" ]

[ "DNA binding", "positive regulation of DNA-templated transcription", "membrane" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PIRSF" ]

[ "PIRSF036354" ]

[ "NosR" ]

[ 1845 ]

1

[]

0

[]

0

[ "PUB00053871" ]

[ "15743947" ]

[ "Functional domains of NosR, a novel transmembrane iron-sulfur flavoprotein necessary for nitrous oxide respiration." ]

[ 2005 ]

1

[]

0

null

[ "Bacteria", "unclassified sequences" ]

[ 1825, 20 ]

2

[]

0

true

Family

Nitrous oxide reductase expression regulator NosR

NosR

4

IPR011400

11,400

Eukaryotic translation initiation factor 3 subunit B

EIF3B

Family

8,453

false

Eukaryotic translation initiation factor 3 subunit B (EIF3B) is a component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. EIF3B is considered to be the major scaffolding subunit and interacts with subunits A, G, I, and J [ ...

[ "GO:0003723", "GO:0003743", "GO:0031369", "GO:0006413", "GO:0005852" ]

[ "RNA binding", "translation initiation factor activity", "translation initiation factor binding", "translational initiation", "eukaryotic translation initiation factor 3 complex" ]

[ "molecular_function", "molecular_function", "molecular_function", "biological_process", "cellular_component" ]

5

[ "HAMAP", "PIRSF", "PANTHER" ]

[ "MF_03001", "PIRSF036424", "PTHR14068" ]

[ "eIF3b", "eIF3b", "" ]

[ 4518, 4197, 8452 ]

3

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-156827", "R-BTA-72649", "R-BTA-72689", "R-BTA-72695", "R-BTA-72702", "R-CEL-156827", "R-CEL-72649", "R-CEL-72689", "R-CEL-72695", "R-CEL-72702", "R-DDI-156827", "R-DDI-72689", "R-DDI-72695", "R-DDI-72702", "R-DME-156827", "R-DME-72649", "R-DME-72689", "R-DME-72695", "R-DME...

[ "REACTOME:R-BTA-156827", "REACTOME:R-BTA-72649", "REACTOME:R-BTA-72689", "REACTOME:R-BTA-72695", "REACTOME:R-BTA-72702", "REACTOME:R-CEL-156827", "REACTOME:R-CEL-72649", "REACTOME:R-CEL-72689", "REACTOME:R-CEL-72695", "REACTOME:R-CEL-72702", "REACTOME:R-DDI-156827", "REACTOME:R-DDI-72689", "...

46

[ "2krb", "2nlw", "3ns5", "3ns6", "4nox", "4u1f", "4uer", "5a5u", "5k1h", "6fec", "6fyx", "6fyy", "6gsm", "6gsn", "6ybt", "6zce", "6zmw", "6zon", "6zp4", "6zu9", "6zvj", "7a09", "7qp6", "7qp7", "8cah", "8cas", "8oz0", "8pj1", "8pj2", "8pj3", "8pj4", "8pj5"...

36

[ "PUB00055362", "PUB00064778" ]

[ "20862284", "18599441" ]

[ "Crystal structure of the RNA recognition motif of yeast translation initiation factor eIF3b reveals differences to human eIF3b.", "Mass spectrometry reveals modularity and a complete subunit interaction map of the eukaryotic translation factor eIF3." ]

[ 2010, 2008 ]

2

[]

0

null

[ "Eukaryota", "viral metagenome" ]

[ 8452, 1 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 15, 1, 1, 2, 9, 3, 1, 3, 4, 1, 1, 4 ]

12

true

Family

Eukaryotic translation initiation factor 3 subunit B

EIF3B

8

IPR011402

11,402

Phospholipase D, plant

PLipase_D_pln

Family

4,813

false

This entry represents the plant phospholipase D (PLD), a calcium-dependent enzyme that hydrolyses glycerol-phospholipids at the terminal phosphodiesteric bond. Arabidopsis PLD has been implicated in plant response to macronutrient availability [ ]. PLD alpha 1 from Setaria italica (foxtail millet) has been linked to dr...

[ "GO:0004630", "GO:0005509", "GO:0046470", "GO:0016020" ]

[ "D-type glycerophospholipase activity", "calcium ion binding", "phosphatidylcholine metabolic process", "membrane" ]

[ "molecular_function", "molecular_function", "biological_process", "cellular_component" ]

4

[ "PIRSF" ]

[ "PIRSF036470" ]

[ "PLD_plant" ]

[ 4813 ]

1

[ "EC", "METACYC", "METACYC" ]

[ "3.1.4.4", "PWY-3561", "PWY-7039" ]

[ "EC:3.1.4.4", "METACYC:PWY-3561", "METACYC:PWY-7039" ]

3

[ "6kz8", "6kz9" ]

2

[ "PUB00076682", "PUB00076683" ]

[ "26260942", "20490504" ]

[ "Phospholipase Dε enhances Braasca napus growth and seed production in response to nitrogen availability.", "Overexpression of a PLDα1 gene from Setaria italica enhances the sensitivity of Arabidopsis to abscisic acid and improves its drought tolerance." ]

[ 2015, 2010 ]

2

[ "IPR015679" ]

[]

1

0

1

[ "Eukaryota" ]

[ 4813 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 41, 33, 52 ]

3

true

Family

Phospholipase D, plant

PLipase_D_pln

1

IPR011404

11,404

Pyrophosphate--fructose 6-phosphate 1-phosphotransferase

PPi-PFK

Family

3,729

false

This entry represents pyrophosphate--fructose 6-phosphate 1-phosphotransferase, initially described as XF0274 type [ ]. It catalyses the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis [ , ].

[ "GO:0047334", "GO:0006096" ]

[ "diphosphate-fructose-6-phosphate 1-phosphotransferase activity", "glycolytic process" ]

[ "molecular_function", "biological_process" ]

2

[ "HAMAP" ]

[ "MF_01978" ]

[ "Phosphofructokinase_II_B2" ]

[ 3729 ]

1

[ "EC", "METACYC", "METACYC" ]

[ "2.7.1.90", "PWY-1042", "PWY-8178" ]

[ "EC:2.7.1.90", "METACYC:PWY-1042", "METACYC:PWY-8178" ]

3

[ "3hno", "3k2q" ]

2

[ "PUB00014634", "PUB00074133", "PUB00074135" ]

[ "14585511", "19054082", "24508689" ]

[ "Rampant horizontal gene transfer and phospho-donor change in the evolution of the phosphofructokinase.", "Characterization of the pyrophosphate-dependent 6-phosphofructokinase from Methylococcus capsulatus Bath.", "Characterization of the pyrophosphate-dependent 6-phosphofructokinase from Xanthomonas campestri...

[ 2003, 2008, 2014 ]

3

[ "IPR022953" ]

[]

1

0

1

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 3642, 5, 82 ]

3

[]

0

true

Family

Pyrophosphate--fructose 6-phosphate 1-phosphotransferase

PPi-PFK

7

IPR011405

11,405

Pyrophosphate-dependent phosphofructokinase SMc01852 type

PPi-PFK_SMc01852

Family

1,127

false

This entry represents a family of pyrophosphate-dependent phosphofructokinases. It catalyses the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis [ , ].

[ "GO:0047334", "GO:0006096" ]

[ "diphosphate-fructose-6-phosphate 1-phosphotransferase activity", "glycolytic process" ]

[ "molecular_function", "biological_process" ]

2

[ "HAMAP", "NCBIFAM", "PIRSF" ]

[ "MF_01977", "NF005121", "PIRSF036484" ]

[ "Phosphofructokinase_II_P", "PRK06555.1", "PPi-PFK_SMc01852" ]

[ 1006, 1127, 891 ]

3

[ "EC", "METACYC", "METACYC" ]

[ "2.7.1.90", "PWY-1042", "PWY-8178" ]

[ "EC:2.7.1.90", "METACYC:PWY-1042", "METACYC:PWY-8178" ]

3

[]

0

[ "PUB00074136", "PUB00074137" ]

[ "20868748", "16480155" ]

[ "Characterization of recombinant pyrophosphate-dependent 6-phosphofructokinase from halotolerant methanotroph Methylomicrobium alcaliphilum 20Z.", "Identification and cloning of the gene encoding pyrophosphate-dependent 6-phosphofructokinase of Methylomonas methanica." ]

[ 2010, 2005 ]

2

[ "IPR022953" ]

[]

1

0

1

[ "Bacteria", "Eukaryota", "metagenomes", "unclassified Candidatus Thermoprofundales" ]

[ 1024, 65, 33, 5 ]

4

[]

0

true

Family

Pyrophosphate-dependent phosphofructokinase SMc01852 type

PPi-PFK_SMc01852

4

IPR011406

11,406

Globin, trematode

Globin_trematode

Family

27

false

Globins are haem-containing proteins involved in binding and/or transporting oxygen. They belong to a very large and well studied family that is widely distributed in many organisms [ ]. Globins have evolved from a common ancestor and can be divided into three groups: single-domain globins, and two types of chimeric gl...

[ "GO:0005506", "GO:0019825", "GO:0020037", "GO:0015671" ]

[ "iron ion binding", "oxygen binding", "heme binding", "oxygen transport" ]

[ "molecular_function", "molecular_function", "molecular_function", "biological_process" ]

4

[ "PIRSF" ]

[ "PIRSF036488" ]

[ "Myoglobin_tremt" ]

[ 27 ]

1

[]

0

[ "1h97", "1kfr" ]

2

[ "PUB00014637", "PUB00014638", "PUB00014639", "PUB00016016", "PUB00029465", "PUB00035865", "PUB00035866", "PUB00035867", "PUB00035868", "PUB00035869", "PUB00035870", "PUB00035871", "PUB00035872", "PUB00035873", "PUB00035877", "PUB00055462", "PUB00055463", "PUB00153677" ]

[ "9006947", "9006948", "9675199", "15096613", "12962627", "16600051", "17540514", "11092893", "11481493", "15598488", "16888280", "15598493", "15339940", "15804833", "17084861", "17540516", "17701548", "21495624" ]

[ "Trematode myoglobins, functional molecules with a distal tyrosine.", "Solution of 1H NMR structure of the heme cavity in the oxygen-avid myoglobin from the trematode Paramphistomum epiclitum.", "Trematode hemoglobins show exceptionally high oxygen affinity.", "Ancestral hemoglobins in Archaea.", "Human bra...

[ 1997, 1997, 1998, 2004, 2003, 2006, 2007, 2001, 2001, 2005, 2006, 2005, 2004, 2004, 2007, 2007, 2007, 2011 ]

18

[]

0

null

[ "Digenea" ]

[ 27 ]

1

[]

0

true

Family

Globin, trematode

Globin_trematode

8

IPR011408

11,408

Aldehyde dehydrogenase

Aldehyde_DH

Family

1,705

false

This group represents a predicted aldehyde dehydrogenase with a duplicated domain. Even though the proteins in this entry belong to the aldehyde dehydrogenase family, the active site cysteine and glutamate residues are not conserved. Their activity is, therefore, not clear.

[]

0

[ "PIRSF" ]

[ "PIRSF036490" ]

[ "Aldedh_dupl" ]

[ 1705 ]

1

[]

0

[ "6mvr", "6mvs", "6mvt", "6mvu" ]

4

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "ecological metagenomes", "uncultured marine group II/III euryarchaeote KM3_57_F04" ]

[ 1333, 356, 15, 1 ]

4

[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 3, 4 ]

3

true

Family

Aldehyde dehydrogenase

Aldehyde_DH

6

IPR011410

11,410

Nucleoside diphosphate kinase 7

NDPK7

Family

1,538

false

The nm23-H7 nucleoside diphosphate kinase (also known as NDPk7 or NME7) consists of an N-terminal DM10 domain and two functional catalytic NDPk modules, NDPk7A and NDPk7B. The function of the DM10 domain, which also occurs in multiple copies in other proteins, is unknown. NDPk7 is predominantly expressed in testes, alt...

[ "GO:0004550", "GO:0005524" ]

[ "nucleoside diphosphate kinase activity", "ATP binding" ]

[ "molecular_function", "molecular_function" ]

2

[ "PIRSF" ]

[ "PIRSF036503" ]

[ "NDK7" ]

[ 1538 ]

1

[ "EC", "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "2.7.11.1", "3.1.11.-", "R-BTA-380270", "R-BTA-380320", "R-HSA-380270", "R-HSA-380320", "R-MMU-380270", "R-MMU-380320", "R-RNO-380270", "R-RNO-380320" ]

[ "EC:2.7.11.1", "EC:3.1.11.-", "REACTOME:R-BTA-380270", "REACTOME:R-BTA-380320", "REACTOME:R-HSA-380270", "REACTOME:R-HSA-380320", "REACTOME:R-MMU-380270", "REACTOME:R-MMU-380320", "REACTOME:R-RNO-380270", "REACTOME:R-RNO-380320" ]

10

[ "6u42", "7rro", "7ung", "8g2z", "8g3d", "8glv", "8i7r", "8iyj", "8j07", "8otz", "8sf7", "8snb", "8to0", "9cpb", "9cpc", "9fqr" ]

16

[ "PUB00014641", "PUB00085496", "PUB00085503" ]

[ "11768308", "15726650", "19421718" ]

[ "The human Nm23/nucleoside diphosphate kinases.", "Expression of the nm23 homologues nm23-H4, nm23-H6, and nm23-H7 in human gastric and colon cancer.", "The NM23 family in development." ]

[ 2000, 2005, 2009 ]

3

[ "IPR001564" ]

[]

1

0

1

[ "Eukaryota" ]

[ 1538 ]

1

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 2, 3, 4, 5 ]

5

true

Family

Nucleoside diphosphate kinase 7

NDPK7

1

IPR011411

11,411

NTP pyrophosphohydrolase MazG-related, YvdC

MazG-related_YvdC

Family

1,276

false

Members of this group are distantly related to MazG-type NTP pyrophosphohydrolase. Conserved residues of the MazG domain (at least three of the Glu residues, Asp, Lys and Arg), including those shown to be functionally important [ ], are also conserved here. MazG protein of Thermotoga maritima has been shown to have bot...

[]

0

[ "PIRSF" ]

[ "PIRSF036521" ]

[ "UCP036521_pph" ]

[ 1276 ]

1

[]

0

[]

0

[ "PUB00013554", "PUB00014610" ]

[ "12657645", "12218018" ]

[ "Thermotoga maritima MazG protein has both nucleoside triphosphate pyrophosphohydrolase and pyrophosphatase activities.", "MazG, a nucleoside triphosphate pyrophosphohydrolase, interacts with Era, an essential GTPase in Escherichia coli." ]

[ 2003, 2002 ]

2

[ "IPR047046" ]

[]

1

0

1

[ "Archaea", "Bacteria", "Viruses", "metagenomes" ]

[ 29, 1223, 8, 16 ]

4

[]

0

true

Family

NTP pyrophosphohydrolase MazG-related, YvdC

MazG-related_YvdC

3

IPR011412

11,412

Coronamic acid biosynthesis thioesterase CmaT

CmaT_thioesters

Family

2

false

This group represents a coronamic acid biosynthesis thioesterase CmaT. Please see the following relevant reference: [ ].

[]

0

[ "PIRSF" ]

[ "PIRSF036539" ]

[ "CmaT_thioesters" ]

[ 2 ]

1

[]

0

[]

0

[ "PUB00014642" ]

[ "8002582" ]

[ "The biosynthetic gene cluster for coronamic acid, an ethylcyclopropyl amino acid, contains genes homologous to amino acid-activating enzymes and thioesterases." ]

[ 1994 ]

1

[ "IPR012223" ]

[]

1

0

1

[ "Pseudomonas syringae" ]

[ 2 ]

1

[]

0

true

Family

Coronamic acid biosynthesis thioesterase CmaT

CmaT_thioesters

7

IPR011413

11,413

Uncharacterised conserved protein UCP036540

UCP036540_AIR

Family

1,136

false

Members of this family belong to a large group that also contains thiamine monophosphate kinase ( ), hydrogenase maturation factor HypE ( ), AIR synthase, FGAM synthase ( ), selenophosphate synthase ( ), and other groups. In AIR synthase, the N-terminal domain forms the dimer interface of the protein and, upon dimerisa...

[]

0

[ "PIRSF", "CDD" ]

[ "PIRSF036540", "cd02192" ]

[ "UCP036540_AIR", "PurM-like3" ]

[ 1076, 1110 ]

2

[]

0

[]

0

[ "PUB00014643" ]

[ "10508786" ]

[ "X-ray crystal structure of aminoimidazole ribonucleotide synthetase (PurM), from the Escherichia coli purine biosynthetic pathway at 2.5 A resolution." ]

[ 1999 ]

1

[ "IPR006283" ]

[ "IPR017668", "IPR024030" ]

1

2

0

[ "Archaea", "Bacteria", "Ricinus communis", "ecological metagenomes" ]

[ 246, 879, 1, 10 ]

4

[]

0

true

Family

Uncharacterised conserved protein UCP036540

UCP036540_AIR

3

IPR011414

11,414

Uncharacterised conserved protein UCP036541

UCP036541_AIR

Family

26

false

Members of this family belong to a large group that also contains thiamine monophosphate kinase, hydrogenase maturation factor HypE ( ), AIR synthase, FGAM synthase ( ), selenophosphate synthetase ( ), and other groups. In AIR synthase, the N-terminal domain forms the dimer interface of the protein and, upon dimerisati...

[]

0

[ "PIRSF" ]

[ "PIRSF036541" ]

[ "UCP036541_AIR" ]

[ 26 ]

1

[]

0

[]

0

[ "PUB00014643" ]

[ "10508786" ]

[ "X-ray crystal structure of aminoimidazole ribonucleotide synthetase (PurM), from the Escherichia coli purine biosynthetic pathway at 2.5 A resolution." ]

[ 1999 ]

1

[ "IPR006283" ]

[]

1

0

1

[ "Methanomada group" ]

[ 26 ]

1

[]

0

true

Family

Uncharacterised conserved protein UCP036541

UCP036541_AIR

8

IPR011415

11,415

Predicted bifunctional spore maturation protein, fused SpmA/SpmB

SpmA_SpmB

Family

2,976

false

This group contains two-domain proteins that are fusions of spore maturation protein A (SpmA) and spore maturation protein B (SpmB). SpmA and SpmB are thought to be involved in spore core dehydration in Bacillus subtilis. Spore dehydration is important for heat resistance, and for processing the spore germination prote...

[]

0

[ "PIRSF" ]

[ "PIRSF036542" ]

[ "SpmA_SpmB" ]

[ 2976 ]

1

[]

0

[]

0

[ "PUB00009933", "PUB00014609", "PUB00014645" ]

[ "7642500", "1548223", "8188581" ]

[ "The Bacillus subtilis dacB gene, encoding penicillin-binding protein 5*, is part of a three-gene operon required for proper spore cortex synthesis and spore core dehydration.", "Isolation and sequence analysis of dacB, which encodes a sporulation-specific penicillin-binding protein in Bacillus subtilis.", "Stu...

[ 1995, 1992, 1994 ]

3

[]

0

null

[ "Bacteria", "metagenomes" ]

[ 2933, 43 ]

2

[]

0

true

Family

Predicted bifunctional spore maturation protein, fused SpmA/SpmB

SpmA_SpmB

9

IPR011416

11,416

Predicted RNA-binding protein YdrC-type, Chlamydia

YdrC-type_chlamyd

Family

21

false

This group contains homologues of Escherichia coli YrdC with an additional unique short (~100 aa) C-terminal domain. In accordance with its proposed role as a translation factor, YrdC preferentially binds dsRNA, likely via a depression on the surface of the protein [ ]. However, members of both this group lack the C-te...

[]

0

[ "PIRSF" ]

[ "PIRSF036543" ]

[ "YdrC_chlamyd" ]

[ 21 ]

1

[]

0

[]

0

[ "PUB00011086", "PUB00011089" ]

[ "11206077", "1325384" ]

[ "The structure of the yrdC gene product from Escherichia coli reveals a new fold and suggests a role in RNA binding.", "Isolation and characterization of SUA5, a novel gene required for normal growth in Saccharomyces cerevisiae." ]

[ 2000, 1992 ]

2

[]

0

null

[ "Chlamydia" ]

[ 21 ]

1

[]

0

true

Family

Predicted RNA-binding protein YdrC-type, Chlamydia

YdrC-type_chlamyd

4

IPR011417

11,417

AP180 N-terminal homology (ANTH) domain

ANTH_dom

Domain

27,473

false

The AP180 N-terminal homology (ANTH) domain is a membrane binding domain found in endocytotic accessory proteins, such as AP180. AP180 has been implicated in the formation of clathrin-coated pits. The ANTH domain is involved in phosphatidylinositol 4,5-bisphosphate (also known as PIP2) binding. The ANTH domain containi...

[ "GO:0005543" ]

[ "phospholipid binding" ]

[ "molecular_function" ]

1

[ "PFAM" ]

[ "PF07651" ]

[ "ANTH" ]

[ 27473 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-CEL-432722", "R-CEL-8856825", "R-CEL-8856828", "R-DME-432722", "R-DME-8856825", "R-DME-8856828", "R-HSA-432722", "R-HSA-8856825", "R-HSA-8856828", "R-HSA-9696264", "R-HSA-9700645", "R-HSA-9725370", "R-MMU-432722", "R-MMU-8856825", "R-MMU-8856828", "R-MMU-9696264", "R-RNO-432722", ...

[ "REACTOME:R-CEL-432722", "REACTOME:R-CEL-8856825", "REACTOME:R-CEL-8856828", "REACTOME:R-DME-432722", "REACTOME:R-DME-8856825", "REACTOME:R-DME-8856828", "REACTOME:R-HSA-432722", "REACTOME:R-HSA-8856825", "REACTOME:R-HSA-8856828", "REACTOME:R-HSA-9696264", "REACTOME:R-HSA-9700645", "REACTOME:R...

21

[ "1hf8", "1hfa", "1hg2", "1hg5", "1hx8", "3zyk", "3zyl", "3zym", "5ahv", "5oo7", "7b2l", "7jxv", "7ost" ]

13

[ "PUB00014713", "PUB00014714" ]

[ "12740367", "12742163" ]

[ "Contrasting membrane interaction mechanisms of AP180 N-terminal homology (ANTH) and epsin N-terminal homology (ENTH) domains.", "ENTH/ANTH domains expand to the Golgi." ]

[ 2003, 2003 ]

2

[]

0

null

[ "Eukaryota", "Satyrvirus sp.", "Splendidivirga corallicola" ]

[ 27471, 1, 1 ]

3

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 75, 3, 142, 13, 24, 26, 2, 47, 35, 3, 2, 116 ]

12

true

Domain

AP180 N-terminal homology (ANTH) domain

ANTH_dom

1

IPR011419

11,419

ATP12, ATP synthase F1-assembly protein

ATP12_ATP_synth-F1-assembly

Family

7,443

false

This entry represents a group proteins from eukaryotes and bacteria that may have chaperone activity and be involved in F1 ATPase complex assembly. The eukaryotic proteins include yeast ATP12 [ ] and mammalian homologue ATPAF2 (ATP synthase mitochondrial F1 complex assembly factor 2) [ ], which are required for assembl...

[ "GO:0043461" ]

[ "proton-transporting ATP synthase complex assembly" ]

[ "biological_process" ]

1

[ "PFAM", "PANTHER" ]

[ "PF07542", "PTHR21013" ]

[ "ATP12", "" ]

[ 7254, 7290 ]

2

[]

0

[ "2p4x", "2r31", "2r6i", "2zd2" ]

4

[ "PUB00014715", "PUB00081959" ]

[ "1826907", "12965202" ]

[ "Characterization of ATP12, a yeast nuclear gene required for the assembly of the mitochondrial F1-ATPase.", "Differential expression of ATPAF1 and ATPAF2 genes encoding F(1)-ATPase assembly proteins in mouse tissues." ]

[ 1991, 2003 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 2889, 4529, 25 ]

3

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 5, 2, 1, 2, 4, 2, 1, 3, 8, 1, 1, 5 ]

12

true

Family

ATP12, ATP synthase F1-assembly protein

ATP12_ATP_synth-F1-assembly

8

IPR011420

11,420

Nitrogen regulatory AreA, N-terminal

AreA_N

Domain

202

false

The AreA nitrogen regulatory proteins (which are GATA type transcription factors) share a highly conserved N terminus and have at the C terminus.

[ "GO:0003677", "GO:0008270", "GO:0042128", "GO:0005634" ]

[ "DNA binding", "zinc ion binding", "nitrate assimilation", "nucleus" ]

[ "molecular_function", "molecular_function", "biological_process", "cellular_component" ]

4

[ "PFAM" ]

[ "PF07573" ]

[ "AreA_N" ]

[ 202 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Mycetocola zhujimingii", "leotiomyceta" ]

[ 1, 201 ]

2

[]

0

true

Domain

Nitrogen regulatory AreA, N-terminal

AreA_N

9

IPR011421

11,421

BCNT-C domain

BCNT-C

Domain

4,277

false

Vertebrate BCNT (named after Bucentaur) protein is found in the nucleus and cytosol. Gene duplication of the ancestral BCNT gene leads to the h-type BCNT or craniofacial development protein 1 (CFDP1) gene and the ruminant-specific p97BCNT or craniofacial development protein 2 (CFDP2) gene. The h-type BCNT proteins cont...

[]

0

[ "PFAM", "PROFILE" ]

[ "PF07572", "PS51279" ]

[ "BCNT", "BCNT_C" ]

[ 4270, 4229 ]

2

[]

0

[ "8qyv", "8qz0" ]

2

[ "PUB00019215", "PUB00043792", "PUB00043793" ]

[ "12832649", "16384818", "14720462" ]

[ "A transposable element-mediated gene divergence that directly produces a novel type bovine Bcnt protein including the endonuclease domain of RTE-1.", "A tandem gene duplication followed by recruitment of a retrotransposon created the paralogous bucentaur gene (bcntp97) in the ancestral ruminant.", "The Drosoph...

[ 2003, 2006, 2003 ]

3

[]

0

null

[ "Eukaryota", "Streptomyces actuosus" ]

[ 4276, 1 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 3, 1, 1, 1, 2, 1, 1, 3, 5, 1, 1, 12 ]

12

true

Domain

BCNT-C domain

BCNT-C

6

IPR011422

11,422

BRCA1-associated 2/ETP1, RRM

BRAP2/ETP1_RRM

Domain

5,140

false

This entry represents the RNA-binding domain (also referred to as RNA recognition motif (RRM)) of BRAP2 and its homologues. This entry includes human BRCA1-associated protein (BRAP/BRAP2, also known as impedes mitogenic signal propagation (IMP), RING finger protein 52, or renal carcinoma antigen NY-REN-63) and its homo...

[]

0

[ "PFAM" ]

[ "PF07576" ]

[ "BRAP2" ]

[ 5140 ]

1

[ "EC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "2.3.2.27", "PWY-7511", "R-CEL-5673000", "R-CEL-5675221", "R-HSA-5673000", "R-HSA-5675221", "R-HSA-6802946", "R-HSA-6802955", "R-HSA-9649948", "R-MMU-5673000", "R-MMU-5675221" ]

[ "EC:2.3.2.27", "METACYC:PWY-7511", "REACTOME:R-CEL-5673000", "REACTOME:R-CEL-5675221", "REACTOME:R-HSA-5673000", "REACTOME:R-HSA-5675221", "REACTOME:R-HSA-6802946", "REACTOME:R-HSA-6802955", "REACTOME:R-HSA-9649948", "REACTOME:R-MMU-5673000", "REACTOME:R-MMU-5675221" ]

11

[]

0

[ "PUB00014718", "PUB00033420", "PUB00054094", "PUB00084641", "PUB00084644", "PUB00084647" ]

[ "9497340", "14724641", "10508479", "19416103", "15340083", "20040518" ]

[ "Identification of a novel cytoplasmic protein that specifically binds to nuclear localization signal motifs.", "Ras regulates assembly of mitogenic signalling complexes through the effector protein IMP.", "Antigens recognized by autologous antibody in patients with renal-cell carcinoma.", "ETP1/YHL010c is a ...

[ 1998, 2004, 1999, 2009, 2004, 2010 ]

6

[]

[ "IPR034931", "IPR034932" ]

0

2

0

[ "Eukaryota" ]

[ 5140 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 11, 1, 2, 2, 4, 2, 1, 5, 4, 1, 1, 12 ]

12

true

Domain

BRCA1-associated 2/ETP1, RRM

BRAP2/ETP1_RRM

7

IPR011425

11,425

Mediator of RNA polymerase II transcription subunit 9

Med9

Family

2,480

false

This entry represents subunit Med9 of the Mediator complex. Subunit Med9 is part of the middle module of the Mediator complex [ ]; this associates with the core polymerase subunits to form the RNA polymerase II holoenzyme. Med9 alternatively known as the chromosome segregation protein, CSE2 ( ) is required, along with ...

[ "GO:0003712", "GO:0006357", "GO:0016592" ]

[ "transcription coregulator activity", "regulation of transcription by RNA polymerase II", "mediator complex" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PFAM" ]

[ "PF07544" ]

[ "Med9" ]

[ 2480 ]

1

[ "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-1989781", "R-HSA-381340", "R-HSA-9833110" ]

[ "REACTOME:R-HSA-1989781", "REACTOME:R-HSA-381340", "REACTOME:R-HSA-9833110" ]

3

[ "5oqm", "5sva", "6w1s", "6xp5", "7emf", "7ena", "7enc", "7enj", "7lbm", "7nvr", "7ui9", "7uif", "7uig", "7uio", "8cen", "8ceo", "8gxq", "8gxs", "8t1i", "8t1l", "8t9d", "8tqw", "8trh" ]

23

[ "PUB00014720", "PUB00053705" ]

[ "8336709", "19077037" ]

[ "CSE1 and CSE2, two new genes required for accurate mitotic chromosome segregation in Saccharomyces cerevisiae.", "Saccharomyces cerevisiae Med9 comprises two functionally distinct domains that play different roles in transcriptional regulation." ]

[ 1993, 2009 ]

2

[]

[ "IPR039242" ]

0

1

0

[ "Eukaryota", "Hylemonella gracilis" ]

[ 2478, 2 ]

2

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)" ]

[ 1, 2, 1, 1, 1, 2, 1 ]

7

true

Family

Mediator of RNA polymerase II transcription subunit 9

Med9

8

IPR011426

11,426

CamS sex pheromone cAM373

CamS

Family

2,493

false

This family includes CamS ( ), from which Staphylococcus aureus sex pheromone staph-cAM373 is processed. It also includes a number of uncharacterised bacterial proteins.

[]

0

[ "PFAM", "PIRSF" ]

[ "PF07537", "PIRSF012509" ]

[ "CamS", "CamS" ]

[ 2493, 2346 ]

2

[]

0

[ "2qx2", "3ib5", "3n2q", "4hn3" ]

4

[]

0

[]

0

null

[ "Bacteria", "Rhizophagus irregularis", "metagenomes" ]

[ 2489, 2, 2 ]

3

[]

0

true

Family

CamS sex pheromone cAM373

CamS

2

IPR011427

11,427

Chlamydia polymorphic membrane, middle domain

Polymorphic_membr_middle

Domain

612

false

This domain is found in several Chlamydia polymorphic membrane proteins [ ]. Chlamydia pneumoniae (Chlamydophila pneumoniae) is an obligate intracellular bacterium and a common human pathogen causing infection of the upper and lower respiratory tract. This domain is found between the β-helical repeats ( ) and the C-ter...

[ "GO:0019867" ]

[ "outer membrane" ]

[ "cellular_component" ]

1

[ "PFAM" ]

[ "PF07548" ]

[ "ChlamPMP_M" ]

[ 612 ]

1

[]

0

[]

0

[ "PUB00014841" ]

[ "11254597" ]

[ "Expression of Chlamydia pneumoniae polymorphic membrane protein family genes." ]

[ 2001 ]

1

[]

0

null

[ "Chlamydia" ]

[ 612 ]

1

[]

0

true

Domain

Chlamydia polymorphic membrane, middle domain

Polymorphic_membr_middle

9

IPR011428

11,428

Spore coat protein X/V

Spore_coat_X/V

Domain

735

false

This domain is found in the Bacilli coat protein X as a tandem repeat and as a single domain in coat protein V. The proteins are found in the insoluble fraction [ ].

[ "GO:0030435", "GO:0031160" ]

[ "sporulation resulting in formation of a cellular spore", "spore wall" ]

[ "biological_process", "cellular_component" ]

2

[ "PFAM" ]

[ "PF07552" ]

[ "Coat_X" ]

[ 735 ]

1

[]

0

[ "9lgh" ]

1

[ "PUB00014723" ]

[ "8509331" ]

[ "Cloning and characterization of a cluster of genes encoding polypeptides present in the insoluble fraction of the spore coat of Bacillus subtilis." ]

[ 1993 ]

1

[]

0

null

[ "Bacteria", "Rhizophagus irregularis" ]

[ 734, 1 ]

2

[]

0

true

Domain

Spore coat protein X/V

Spore_coat_X/V

6

IPR011430

11,430

U3 small nucleolar RNA-associated protein 20, N-terminal

UTP20_N

Domain

4,665

false

This entry represents a region of tetratricopeptide-like (TPR) repeats found towards the N-terminal of eukaryotic proteins including U3 small nucleolar RNA-associated protein 20 from yeast and the human homologue, also known as Small subunit processome component 20 homolog or DRIM (Down-Regulated In Metastasis) ( ). DR...

[]

0

[ "PFAM" ]

[ "PF07539" ]

[ "UTP20_N" ]

[ 4665 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-6790901", "R-HSA-6791226", "R-MMU-6791226", "R-SCE-6791226", "R-SPO-6791226" ]

[ "REACTOME:R-HSA-6790901", "REACTOME:R-HSA-6791226", "REACTOME:R-MMU-6791226", "REACTOME:R-SCE-6791226", "REACTOME:R-SPO-6791226" ]

5

[ "6ke6", "6lqp", "6lqq", "6lqr", "6lqs", "6lqt", "6lqu", "6lqv", "6rxu", "6rxv", "6rxx", "6rxz", "6zqb", "6zqc", "6zqd", "6zqe", "7ajt", "7aju", "7d4i", "7d5t", "7d63", "7mq8", "7mq9", "7mqa", "7suk", "9g33", "9n6v", "9n6w", "9n6x", "9n6y", "9n6z", "9n70"...

41

[ "PUB00014724", "PUB00014725", "PUB00101284", "PUB00101285", "PUB00101286" ]

[ "9673349", "12837249", "17498821", "32943522", "31378463" ]

[ "Differential gene expression in mammary carcinoma cell lines: identification of DRIM, a new gene down-regulated in metastasis.", "A panoramic view of yeast noncoding RNA processing.", "Human 1A6/DRIM, the homolog of yeast Utp20, functions in the 18S rRNA processing.", "Cryo-EM structure of 90S small r...

[ 1998, 2003, 2007, 2020, 2019 ]

5

[]

0

null

[ "Eukaryota" ]

[ 4665 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 9, 1, 3, 1, 1, 3, 1, 1, 2, 1, 1, 34 ]

12

true

Domain

U3 small nucleolar RNA-associated protein 20, N-terminal

UTP20_N

1

IPR011431

11,431

Protein trafficking Pga2

Trafficking_Pga2

Family

1,102

false

A Saccharomyces cerevisiae (Baker's yeast) member of this family (PGA2, ) is a single pass membrane protein which is implicated in protein trafficking and processing of glycosylated proteins [ , ].

[]

0

[ "PFAM", "PIRSF", "PANTHER" ]

[ "PF07543", "PIRSF022909", "PTHR28199" ]

[ "PGA2", "UCP022909", "" ]

[ 1078, 330, 1013 ]

3

[]

0

[]

0

[ "PUB00019458", "PUB00044766" ]

[ "14690591", "16943325" ]

[ "Assigning function to yeast proteins by integration of technologies.", "A survey of essential gene function in the yeast cell division cycle." ]

[ 2003, 2006 ]

2

[]

0

null

[ "Eukaryota" ]

[ 1102 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 1, 1 ]

3

true

Family

Protein trafficking Pga2

Trafficking_Pga2

7

IPR011432

11,432

Heme-binding protein Shr-like, Hb-interacting domain

Shr-like_HID

Domain

599

false

This entry represents the Hb-interacting domain (HID), which is found duplicated in Heme-binding protein Shr from Streptococcus pyogenes, a potentially lethal human pathogen, and in one to six copies in other uncharacterised bacterial proteins. Shr is a virulence factor that captures Hb and binds to the oxidized form o...

[]

0

[ "PFAM" ]

[ "PF07550" ]

[ "Shr-like_HID" ]

[ 599 ]

1

[]

0

[ "6dkq", "7cud", "7cue", "8dov" ]

4

[ "PUB00100888", "PUB00155965" ]

[ "30301765", "36693107" ]

[ "The Streptococcus pyogenes Shr protein captures human hemoglobin using two structurally unique binding domains.", "The Shr receptor from Streptococcus pyogenes uses a cap and release mechanism to acquire heme-iron from human hemoglobin." ]

[ 2018, 2023 ]

2

[]

0

null

[ "Bacteria", "metagenomes" ]

[ 597, 2 ]

2

[]

0

true

Domain

Heme-binding protein Shr-like, Hb-interacting domain

Shr-like_HID

5

IPR011434

11,434

Putative host cell surface-exposed lipoprotein Ltp-like, HTH region

Ltp-like_HTH

Domain

1,999

false

This entry represents a domain found as 1 to 5 copies in proteins from bacteria and virus, including Putative host cell surface-exposed lipoprotein from Streptococcus phage TP-J34 (Ltp, ), a superinfection exclusion protein. This domain shows a three-helix bundle belonging to the HTH superfamily [ ].

[]

0

[ "PFAM" ]

[ "PF07553" ]

[ "Lipoprotein_Ltp" ]

[ 1999 ]

1

[]

0

[ "4eqq" ]

1

[ "PUB00101011" ]

[ "23692331" ]

[ "X-ray structure of a superinfection exclusion lipoprotein from phage TP-J34 and identification of the tape measure protein as its target." ]

[ 2013 ]

1

[]

0

null

[ "Bacteria", "Methanobacteriota", "Pancrustacea", "Viruses", "metagenomes" ]

[ 1907, 8, 5, 64, 15 ]

5

[]

0

true

Domain

Putative host cell surface-exposed lipoprotein Ltp-like, HTH region

Ltp-like_HTH

1

IPR011435

11,435

Na(+), Li(+), K(+)/H(+) antiporter subunit A/B

UmpAB

Family

3,163

false

UmpAB function as a two-component Na+(Li+, K+)/H+ antiporter [ ].

[]

0

[ "PFAM" ]

[ "PF07556" ]

[ "DUF1538" ]

[ 3163 ]

1

[]

0

[]

0

[ "PUB00092442" ]

[ "28652569" ]

[ "Characterization of a novel two-component Na+(Li+, K+)/H+ antiporter from Halomonas zhaodongensis." ]

[ 2017 ]

1

[]

[ "IPR048123" ]

0

1

0

[ "Bacteria", "Eukaryota", "Methanobacteriota", "Podoviridae sp. ctxJ29", "unclassified sequences" ]

[ 2836, 99, 130, 1, 97 ]

5

[]

0

true

Family

Na(+), Li(+), K(+)/H(+) antiporter subunit A/B

UmpAB

7

IPR011436

11,436

Domain of unknown function DUF1539

DUF1539

Domain

38

false

This domain is found in a small number of Chlamydia proteins of unknown function. It occurs together with .

[]

0

[ "PFAM" ]

[ "PF07560" ]

[ "DUF1539" ]

[ 38 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria" ]

[ 38 ]

1

[]

0

true

Domain

Domain of unknown function DUF1539

DUF1539

5

IPR011437

11,437

Domain of unknown function DUF1540

DUF1540

Domain

4,975

false

These proteins have four conserved cysteines, which is suggestive of a metal binding function. This domain may be found on its own or duplicated in the proteins.

[]

0

[ "PFAM" ]

[ "PF07561" ]

[ "DUF1540" ]

[ 4975 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Candidatus Methanoperedens nitratireducens", "Eukaryota", "metagenomes", "unclassified Caudoviricetes" ]

[ 4921, 1, 4, 45, 4 ]

5

[]

0

true

Domain

Domain of unknown function DUF1540

DUF1540

7

IPR011438

11,438

Domain of unknown function DUF1541

DUF1541

Domain

1,546

false

This domain is found in several hypothetical bacterial proteins as a tandem repeat.

[]

0

[ "PFAM" ]

[ "PF07563" ]

[ "DUF1541" ]

[ 1546 ]

1

[]

0

[ "2ky9", "4fib", "4mdw" ]

3

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "bioreactor metagenome" ]

[ 1540, 3, 3 ]

3

[]

0

true

Domain

Domain of unknown function DUF1541

DUF1541

9

IPR011439

11,439

Domain of unknown function DUF1542

DUF1542

Domain

1,146

false

This domain is found in several cell surface proteins, such as extracellular matrix-binding protein ebh [ ]. Some members are involved in antibiotic resistance (e.g. and ) [ ] and/or cellular adhesion (e.g. ) [ ]. In some proteins it is repeated more than fifteen times, being the most repeated domain in streptococci [ ...

[]

0

[ "PFAM" ]

[ "PF07564" ]

[ "DUF1542" ]

[ 1146 ]

1

[]

0

[]

0

[ "PUB00014727", "PUB00014728", "PUB00065268", "PUB00097823", "PUB00097824" ]

[ "10332717", "12438342", "22977243", "33465168", "22921469" ]

[ "Mrp--a new auxiliary gene essential for optimal expression of methicillin resistance in Staphylococcus aureus.", "Analysis of Ebh, a 1.1-megadalton cell wall-associated fibronectin-binding protein of Staphylococcus aureus.", "The extracellular protein factor Epf from Streptococcus pyogenes is a cell surface ad...

[ 1999, 2002, 2012, 2021, 2012 ]

5

[]

0

null

[ "Bacteria", "Heliocybe sulcata", "human gut metagenome" ]

[ 1140, 1, 5 ]

3

[]

0

true

Domain

Domain of unknown function DUF1542

DUF1542

2