interpro_id string | interpro_numeric_id int64 | name string | short_name string | entry_type string | protein_count int64 | is_llm bool | is_llm_reviewed bool | abstract string | go_ids list | go_terms list | go_categories list | go_count int64 | member_databases list | member_accessions list | member_names list | member_protein_counts list | member_count int64 | external_databases list | external_accessions list | external_xrefs list | external_xref_count int64 | pdb_ids list | structure_count int64 | publication_ids list | pubmed_ids list | publication_titles list | publication_years list | publication_count int64 | parent_ids list | child_ids list | parent_count int64 | child_count int64 | tree_depth float64 | taxonomy_names list | taxonomy_protein_counts list | taxonomy_count int64 | key_species_names list | key_species_protein_counts list | key_species_count int64 | in_entry_list bool | entry_list_type string | entry_list_name string | names_dat_name string | short_names_dat_name string | split_bucket int64 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
IPR011611 | 11,611 | Carbohydrate kinase PfkB | PfkB_dom | Domain | 182,873 | false | false | This domain is found in a variety of carbohydrate and pyrimidine kinases. It is found in phosphomethylpyrimidine kinase ( ), which is part of the thiamine pyrophosphate (TPP) synthesis pathway -TPP being an essential cofactor for many enzymes [ ]. It is also found in 2-keto-3-deoxygluconate kinase, which is a component... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF00294"
] | [
"PfkB"
] | [
182873
] | 1 | [
"EC",
"GP",
"GP",
"GP",
"GP",
"GP",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"R... | [
"2.7.1",
"GenProp1239",
"GenProp1449",
"GenProp1624",
"GenProp1636",
"GenProp1741",
"R-CEL-6798695",
"R-CEL-964975",
"R-DDI-70350",
"R-DDI-71336",
"R-DDI-74217",
"R-DDI-9755088",
"R-HSA-5657562",
"R-HSA-70350",
"R-HSA-71336",
"R-HSA-74217",
"R-HSA-9755088",
"R-MMU-70350",
"R-MMU-... | [
"EC:2.7.1",
"GP:GenProp1239",
"GP:GenProp1449",
"GP:GenProp1624",
"GP:GenProp1636",
"GP:GenProp1741",
"REACTOME:R-CEL-6798695",
"REACTOME:R-CEL-964975",
"REACTOME:R-DDI-70350",
"REACTOME:R-DDI-71336",
"REACTOME:R-DDI-74217",
"REACTOME:R-DDI-9755088",
"REACTOME:R-HSA-5657562",
"REACTOME:R-H... | 30 | [
"1bx4",
"1dgm",
"1gqt",
"1lii",
"1lij",
"1lik",
"1lio",
"1rk2",
"1rka",
"1rkd",
"1rks",
"1tyy",
"1tz3",
"1tz6",
"1v19",
"1v1a",
"1v1b",
"1v1s",
"1vk4",
"1vm7",
"1wye",
"2a9y",
"2a9z",
"2aa0",
"2ab8",
"2abq",
"2abs",
"2afb",
"2ajr",
"2awd",
"2c49",
"2c4e"... | 250 | [
"PUB00005300",
"PUB00058075"
] | [
"9519409",
"15869466"
] | [
"Structure of Escherichia coli ribokinase in complex with ribose and dinucleotide determined to 1.8 A resolution: insights into a new family of kinase structures.",
"The semi-phosphorylative Entner-Doudoroff pathway in hyperthermophilic archaea: a re-evaluation."
] | [
1998,
2005
] | 2 | [] | [
"IPR011913"
] | 0 | 1 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
2761,
146319,
31278,
21,
2494
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
85,
6,
12,
19,
19,
16,
12,
7,
51,
17,
3,
4,
107
] | 13 | true | Domain | Carbohydrate kinase PfkB | Carbohydrate kinase PfkB | PfkB_dom | 7 |
IPR011612 | 11,612 | Urease alpha-subunit, N-terminal domain | Urease_alpha_N_dom | Domain | 15,357 | false | false | Urease (urea amidohydrolase, ) catalyses the hydrolysis of urea to form ammonia and carbamate. The subunit composition of urease from different sources varies [ ], but each holoenzyme consists of four structural domains [ ]: three structural domains and a nickel-binding catalytic domain common to amidohydrolases [ ]. U... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF00449"
] | [
"Urease_alpha"
] | [
15357
] | 1 | [
"EC",
"GP",
"METACYC"
] | [
"3.5.1.5",
"GenProp0051",
"PWY-5704"
] | [
"EC:3.5.1.5",
"GP:GenProp0051",
"METACYC:PWY-5704"
] | 3 | [
"1a5k",
"1a5l",
"1a5m",
"1a5n",
"1a5o",
"1e9y",
"1e9z",
"1ef2",
"1ejr",
"1ejs",
"1ejt",
"1eju",
"1ejv",
"1ejw",
"1ejx",
"1fwa",
"1fwb",
"1fwc",
"1fwd",
"1fwe",
"1fwf",
"1fwg",
"1fwh",
"1fwi",
"1fwj",
"1ie7",
"1kra",
"1krb",
"1krc",
"1nfg",
"1s3t",
"1ubp"... | 86 | [
"PUB00004994",
"PUB00005206",
"PUB00010725"
] | [
"9144792",
"7754395",
"7565414"
] | [
"An evolutionary treasure: unification of a broad set of amidohydrolases related to urease.",
"The crystal structure of urease from Klebsiella aerogenes.",
"Molecular biology of microbial ureases."
] | [
1997,
1995,
1995
] | 3 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
681,
11803,
2723,
150
] | 4 | [
"Arabidopsis thaliana",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)",
"Zea mays"
] | [
6,
2,
1,
1,
15
] | 5 | true | Domain | Urease alpha-subunit, N-terminal domain | Urease alpha-subunit, N-terminal domain | Urease_alpha_N_dom | 7 |
IPR011613 | 11,613 | GH15-like domain | GH15-like | Domain | 33,211 | false | false | This entry represents a domain found in glycoside hydrolase family 15 members and in phosphorylase b kinase regulatory chains alpha and beta [ ]. Glycoside hydrolase family 15 comprises enzymes with several known activities; glucoamylase ( ); alpha-glucosidase ( ); glucodextranase ( ). | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF00723"
] | [
"Glyco_hydro_15"
] | [
33211
] | 1 | [
"EC",
"GP",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"3.2.1",
"GenProp1259",
"R-CEL-70221",
"R-DME-70221",
"R-HSA-70221",
"R-MMU-70221",
"R-RNO-70221"
] | [
"EC:3.2.1",
"GP:GenProp1259",
"REACTOME:R-CEL-70221",
"REACTOME:R-DME-70221",
"REACTOME:R-HSA-70221",
"REACTOME:R-MMU-70221",
"REACTOME:R-RNO-70221"
] | 7 | [
"1agm",
"1ayx",
"1dog",
"1gah",
"1gai",
"1glm",
"1lf6",
"1lf9",
"1ug9",
"1ulv",
"2f6d",
"2fba",
"2vn4",
"2vn7",
"3eqa",
"3gly",
"5z3a",
"5z3b",
"5z3c",
"5z3d",
"5z3e",
"5z3f",
"6fhv",
"6fhw",
"6frv",
"7c24",
"7c25",
"7c26",
"7c27",
"8jfk",
"8jfl",
"8xy7"... | 40 | [
"PUB00074290",
"PUB00088713"
] | [
"12825073",
"18950708"
] | [
"Muscle glycogenosis with low phosphorylase kinase activity: mutations in PHKA1, PHKG1 or six other candidate genes explain only a minority of cases.",
"3D mapping of glycogenosis-causing mutations in the large regulatory alpha subunit of phosphorylase kinase."
] | [
2003,
2008
] | 2 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Mimiviridae",
"unclassified sequences"
] | [
984,
18537,
13519,
2,
169
] | 5 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strai... | [
5,
20,
10,
14,
24,
2,
20,
1,
2
] | 9 | true | Domain | GH15-like domain | GH15-like domain | GH15-like | 4 |
IPR011614 | 11,614 | Catalase core domain | Catalase_core | Domain | 44,395 | false | false | Catalases ( ) are antioxidant enzymes that catalyse the conversion of hydrogen peroxide to water and molecular oxygen, serving to protect cells from its toxic effects [ ]. Hydrogen peroxide is produced as a consequence of oxidative cellular metabolism and can be converted to the highly reactive hydroxyl radical via tra... | [
"GO:0004096",
"GO:0020037"
] | [
"catalase activity",
"heme binding"
] | [
"molecular_function",
"molecular_function"
] | 2 | [
"PFAM",
"SMART"
] | [
"PF00199",
"SM01060"
] | [
"Catalase",
"Catalase"
] | [
44376,
42378
] | 2 | [
"EC",
"GP",
"GP",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
... | [
"1.11.1.6",
"GenProp0213",
"GenProp1379",
"R-BTA-3299685",
"R-BTA-6798695",
"R-BTA-9033241",
"R-CFA-3299685",
"R-CFA-6798695",
"R-CFA-9033241",
"R-DDI-3299685",
"R-DDI-6798695",
"R-DDI-9033241",
"R-DME-3299685",
"R-DME-6798695",
"R-DME-9033241",
"R-DRE-3299685",
"R-DRE-6798695",
"R... | [
"EC:1.11.1.6",
"GP:GenProp0213",
"GP:GenProp1379",
"REACTOME:R-BTA-3299685",
"REACTOME:R-BTA-6798695",
"REACTOME:R-BTA-9033241",
"REACTOME:R-CFA-3299685",
"REACTOME:R-CFA-6798695",
"REACTOME:R-CFA-9033241",
"REACTOME:R-DDI-3299685",
"REACTOME:R-DDI-6798695",
"REACTOME:R-DDI-9033241",
"REACTO... | 34 | [
"1a4e",
"1cf9",
"1dgb",
"1dgf",
"1dgg",
"1dgh",
"1e93",
"1f4j",
"1gg9",
"1gge",
"1ggf",
"1ggh",
"1ggj",
"1ggk",
"1gwe",
"1gwf",
"1gwh",
"1h6n",
"1h7k",
"1hbz",
"1iph",
"1m7s",
"1m85",
"1mqf",
"1nm0",
"1p7y",
"1p7z",
"1p80",
"1p81",
"1qf7",
"1qqw",
"1qwl"... | 162 | [
"PUB00012765",
"PUB00015054",
"PUB00027249",
"PUB00056180"
] | [
"11351128",
"14745498",
"12557185",
"9287428"
] | [
"Mitochondrial catalase and oxidative injury.",
"Diversity of structures and properties among catalases.",
"Structure of the Clade 1 catalase, CatF of Pseudomonas syringae, at 1.8 A resolution.",
"Phylogenetic relationships among prokaryotic and eukaryotic catalases."
] | [
2001,
2004,
2003,
1997
] | 4 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Tupanvirus",
"unclassified sequences"
] | [
192,
29177,
14884,
4,
138
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
25,
4,
2,
6,
1,
5,
8,
3,
7,
4,
2,
1,
14
] | 13 | true | Domain | Catalase core domain | Catalase core domain | Catalase_core | 9 |
IPR011615 | 11,615 | p53, DNA-binding domain | p53_DNA-bd | Domain | 6,297 | false | false | This domain is found in p53 transcription factors, where it is responsible for DNA-binding. The DNA-binding domain acts to clamp, or in the case of TonEBP, encircle the DNA target in order to stabilise the protein-DNA complex [ ]. Protein interactions may also serve to stabilise the protein-DNA complex, for example in ... | [
"GO:0000976"
] | [
"transcription cis-regulatory region binding"
] | [
"molecular_function"
] | 1 | [
"PFAM",
"CDD"
] | [
"PF00870",
"cd08367"
] | [
"P53",
"P53"
] | [
6297,
5573
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-2559580",
"R-BTA-2559586",
"R-BTA-349425",
"R-BTA-5689880",
"R-BTA-5689896",
"R-BTA-5693565",
"R-BTA-6804754",
"R-BTA-6804756",
"R-BTA-6804757",
"R-BTA-6804758",
"R-BTA-6804759",
"R-BTA-6804760",
"R-BTA-6811555",
"R-BTA-69473",
"R-BTA-69481",
"R-BTA-69541",
"R-BTA-69895",
"R... | [
"REACTOME:R-BTA-2559580",
"REACTOME:R-BTA-2559586",
"REACTOME:R-BTA-349425",
"REACTOME:R-BTA-5689880",
"REACTOME:R-BTA-5689896",
"REACTOME:R-BTA-5693565",
"REACTOME:R-BTA-6804754",
"REACTOME:R-BTA-6804756",
"REACTOME:R-BTA-6804757",
"REACTOME:R-BTA-6804758",
"REACTOME:R-BTA-6804759",
"REACTOME... | 150 | [
"1gzh",
"1hu8",
"1kzy",
"1tsr",
"1tup",
"1uol",
"1ycs",
"2ac0",
"2ady",
"2ahi",
"2ata",
"2bim",
"2bin",
"2bio",
"2bip",
"2biq",
"2fej",
"2geq",
"2h1l",
"2ioi",
"2iom",
"2ioo",
"2j1w",
"2j1x",
"2j1y",
"2j1z",
"2j20",
"2j21",
"2mej",
"2ocj",
"2p52",
"2pcx"... | 215 | [
"PUB00000596",
"PUB00001893",
"PUB00002729",
"PUB00004096",
"PUB00004490",
"PUB00011800",
"PUB00011807",
"PUB00079665",
"PUB00079666",
"PUB00079667",
"PUB00079668",
"PUB00079669",
"PUB00079670",
"PUB00079671",
"PUB00079672",
"PUB00079673",
"PUB00079674"
] | [
"2142001",
"2137806",
"1639769",
"2046748",
"2142762",
"11780147",
"9630226",
"20066118",
"12629332",
"1397838",
"6544917",
"19826090",
"19776744",
"6278740",
"221923",
"6318442",
"20030809"
] | [
"Tumor suppressor genes: the p53 and retinoblastoma sensitivity genes and gene products.",
"p53: oncogene or anti-oncogene?",
"The p53 tumor suppressor protein, a modulator of cell proliferation.",
"The p53 tumour suppressor gene.",
"Structural aspects of the p53 protein in relation to gene evolution.",
"... | [
1990,
1990,
1992,
1991,
1990,
2002,
1998,
2009,
2003,
1992,
1984,
2009,
2009,
1982,
1979,
1983,
2009
] | 17 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"bird metagenome"
] | [
6296,
1
] | 2 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
69,
6,
164,
26,
17
] | 5 | true | Domain | p53, DNA-binding domain | p53, DNA-binding domain | p53_DNA-bd | 7 |
IPR011618 | 11,618 | Sorbitol phosphotransferase enzyme II, N-terminal | PTS_EIIBC_GUT_N | Domain | 2,655 | false | false | Bacterial PTS transporters transport and concomitantly phosphorylate their sugar substrates, and typically consist of multiple subunits or protein domains. The Man family is unique in several respects among PTS permease families. It is the only PTS family in which members possess a IID protein. It is the only PTS famil... | [
"GO:0008982",
"GO:0009401",
"GO:0016020"
] | [
"protein-N(PI)-phosphohistidine-sugar phosphotransferase activity",
"phosphoenolpyruvate-dependent sugar phosphotransferase system",
"membrane"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PFAM",
"PROFILE"
] | [
"PF03612",
"PS51102"
] | [
"EIIBC-GUT_N",
"PTS_EIIB_TYPE_5"
] | [
2650,
2651
] | 2 | [
"EC",
"PROSITEDOC"
] | [
"2.7.1.198",
"PDOC00795"
] | [
"EC:2.7.1.198",
"PROSITEDOC:PDOC00795"
] | 2 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Ecdysozoa",
"metagenomes"
] | [
2642,
2,
11
] | 3 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Domain | Sorbitol phosphotransferase enzyme II, N-terminal | Sorbitol phosphotransferase enzyme II, N-terminal | PTS_EIIBC_GUT_N | 1 |
IPR011621 | 11,621 | Metal-dependent phosphohydrolase, 7TM intracellular domain | Metal-dep_PHydrolase_7TM_intra | Domain | 5,429 | false | false | These bacterial 7TM receptor proteins have an intracellular domain . This entry corresponds to the 7 helix transmembrane domain. These proteins also contain an N-terminal extracellular domain [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF07698"
] | [
"7TM-7TMR_HD"
] | [
5429
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00015215"
] | [
"12914674"
] | [
"Application of comparative genomics in the identification and analysis of novel families of membrane-associated receptors in bacteria."
] | [
2003
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
5301,
2,
126
] | 3 | [] | [] | 0 | true | Domain | Metal-dependent phosphohydrolase, 7TM intracellular domain | Metal-dependent phosphohydrolase, 7TM intracellular domain | Metal-dep_PHydrolase_7TM_intra | 9 |
IPR011622 | 11,622 | 7TM-DISM receptor, extracellular domain, type 2 | 7TMR_DISM_rcpt_extracell_dom2 | Domain | 10,110 | false | false | This entry represents one of two distinct types of extracellular domain found in the 7TM-DISM (7TM Receptors with Diverse Intracellular Signalling Modules) bacterial transmembrane proteins [ ]. It is possible that this domain adopts a jelly roll fold and acts as a receptor for carbohydrates and their derivatives [ ]. I... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF07696"
] | [
"7TMR-DISMED2"
] | [
10110
] | 1 | [] | [] | [] | 0 | [
"2xbz",
"3jyb",
"9jpe"
] | 3 | [
"PUB00015215"
] | [
"12914674"
] | [
"Application of comparative genomics in the identification and analysis of novel families of membrane-associated receptors in bacteria."
] | [
2003
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"unclassified sequences",
"uncultured Caudovirales phage"
] | [
10041,
3,
65,
1
] | 4 | [] | [] | 0 | true | Domain | 7TM-DISM receptor, extracellular domain, type 2 | 7TM-DISM receptor, extracellular domain, type 2 | 7TMR_DISM_rcpt_extracell_dom2 | 3 |
IPR011623 | 11,623 | 7TM-DISM receptor, extracellular domain, type 1 | 7TMR_DISM_rcpt_extracell_dom1 | Domain | 16,741 | false | false | This entry represents the transmembrane region of the 7TM-DISM (7TM Receptors with Diverse Intracellular Signalling Modules) [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF07695"
] | [
"7TMR-DISM_7TM"
] | [
16741
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00015215"
] | [
"12914674"
] | [
"Application of comparative genomics in the identification and analysis of novel families of membrane-associated receptors in bacteria."
] | [
2003
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"unclassified sequences",
"uncultured Caudovirales phage"
] | [
16619,
5,
116,
1
] | 4 | [
"Oryza sativa subsp. japonica"
] | [
1
] | 1 | true | Domain | 7TM-DISM receptor, extracellular domain, type 1 | 7TM-DISM receptor, extracellular domain, type 1 | 7TMR_DISM_rcpt_extracell_dom1 | 1 |
IPR011625 | 11,625 | Alpha-2-macroglobulin, bait region domain | A2M_N_BRD | Domain | 29,209 | false | false | Alpha-2-macroglobulins (A2Ms) are plasma proteins that trap and inhibit a broad range of proteases and are major components of the eukaryotic innate immune system [ ]. However, A2M-like proteins were identified in pathogenic invasive bacteria and species that colonize higher eukaryotes. In human A2Ms, this domain encom... | [] | [] | [] | 0 | [
"PFAM",
"SMART"
] | [
"PF07703",
"SM01359"
] | [
"A2M_BRD",
"A2M_N_2"
] | [
28996,
28239
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-173736",
"R-BTA-174577",
"R-BTA-198933",
"R-BTA-375276",
"R-BTA-381426",
"R-BTA-418594",
"R-BTA-6798695",
"R-BTA-8957275",
"R-BTA-977606",
"R-HSA-114608",
"R-HSA-140837",
"R-HSA-1474228",
"R-HSA-163125",
"R-HSA-166663",
"R-HSA-166665",
"R-HSA-173736",
"R-HSA-174577",
"R-HSA-... | [
"REACTOME:R-BTA-173736",
"REACTOME:R-BTA-174577",
"REACTOME:R-BTA-198933",
"REACTOME:R-BTA-375276",
"REACTOME:R-BTA-381426",
"REACTOME:R-BTA-418594",
"REACTOME:R-BTA-6798695",
"REACTOME:R-BTA-8957275",
"REACTOME:R-BTA-977606",
"REACTOME:R-HSA-114608",
"REACTOME:R-HSA-140837",
"REACTOME:R-HSA-1... | 57 | [
"2a73",
"2a74",
"2i07",
"2ice",
"2icf",
"2pn5",
"2qki",
"2wii",
"2win",
"2xwb",
"2xwj",
"3cu7",
"3frp",
"3g6j",
"3hrz",
"3hs0",
"3kls",
"3km9",
"3l3o",
"3l5n",
"3nms",
"3ohx",
"3prx",
"3pvm",
"3t4a",
"4a5w",
"4d94",
"4e0s",
"4lnv",
"4rtd",
"4u48",
"4u4j"... | 108 | [
"PUB00059352",
"PUB00091001",
"PUB00100415"
] | [
"22290936",
"25221932",
"34970276"
] | [
"The Crystal Structure of Human α(2) -Macroglobulin Reveals a Unique Molecular Cage.",
"Structure of a bacterial α2-macroglobulin reveals mimicry of eukaryotic innate immunity.",
"Alpha-2-Macroglobulin in Inflammation, Immunity and Infections."
] | [
2012,
2014,
2021
] | 3 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
21,
10710,
18398,
80
] | 4 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
101,
142,
2,
37,
23,
50
] | 7 | true | Domain | Alpha-2-macroglobulin, bait region domain | Alpha-2-macroglobulin, bait region domain | A2M_N_BRD | 7 |
IPR011626 | 11,626 | Alpha-macroglobulin-like, TED domain | Alpha-macroglobulin_TED | Domain | 26,156 | false | false | This entry corresponds to the TED domain of the complement components such as C3, C4 and C5 [ ]. This domain contains a short highly conserved region of proteinase-binding alpha-macro-globulins contains the cysteine and a glutamine of a thiol-ester bond that is cleaved at the moment of proteinase binding, and mediates ... | [
"GO:0005615"
] | [
"extracellular space"
] | [
"cellular_component"
] | 1 | [
"PFAM"
] | [
"PF07678"
] | [
"TED_complement"
] | [
26156
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-173736",
"R-BTA-174577",
"R-BTA-198933",
"R-BTA-375276",
"R-BTA-381426",
"R-BTA-418594",
"R-BTA-6798695",
"R-BTA-8957275",
"R-BTA-977606",
"R-HSA-114608",
"R-HSA-140837",
"R-HSA-1474228",
"R-HSA-163125",
"R-HSA-166663",
"R-HSA-166665",
"R-HSA-173736",
"R-HSA-174577",
"R-HSA-... | [
"REACTOME:R-BTA-173736",
"REACTOME:R-BTA-174577",
"REACTOME:R-BTA-198933",
"REACTOME:R-BTA-375276",
"REACTOME:R-BTA-381426",
"REACTOME:R-BTA-418594",
"REACTOME:R-BTA-6798695",
"REACTOME:R-BTA-8957275",
"REACTOME:R-BTA-977606",
"REACTOME:R-HSA-114608",
"REACTOME:R-HSA-140837",
"REACTOME:R-HSA-1... | 57 | [
"1c3d",
"1ghq",
"1hzf",
"1qqf",
"1qsj",
"1w2s",
"2a73",
"2gox",
"2i07",
"2icf",
"2noj",
"2pn5",
"2wii",
"2win",
"2wy7",
"2wy8",
"2xqw",
"2xwb",
"2xwj",
"3cu7",
"3d5r",
"3d5s",
"3g6j",
"3kls",
"3km9",
"3l5n",
"3oed",
"3oxu",
"3prx",
"3pvm",
"3rj3",
"4a5w"... | 123 | [
"PUB00011876",
"PUB00019076",
"PUB00019077",
"PUB00019078",
"PUB00100415"
] | [
"11106161",
"10625650",
"11387479",
"10825534",
"34970276"
] | [
"Structure of a rat alpha 1-macroglobulin receptor-binding domain dimer.",
"NMR solution structure of the receptor binding domain of human alpha(2)-macroglobulin.",
"Structure of complement receptor 2 in complex with its C3d ligand.",
"Structure at 1.44 A resolution of an N-terminally truncated form of the ra... | [
2000,
2000,
2001,
2000,
2021
] | 5 | [] | [
"IPR041813"
] | 0 | 1 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"Megaviridae environmental sample",
"metagenomes"
] | [
47,
5752,
20292,
1,
64
] | 5 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
112,
82,
1,
40,
26,
53
] | 7 | true | Domain | Alpha-macroglobulin-like, TED domain | Alpha-macroglobulin-like, TED domain | Alpha-macroglobulin_TED | 9 |
IPR011628 | 11,628 | Cleaved adhesin | Cleaved_adhesin | Domain | 1,210 | false | false | This conserved region is found in a group of haemagglutinins and peptidases, e.g. , that, in Porphyromonas gingivalis (Bacteroides gingivalis), form components of the major extracellular virulence complex RgpA-Kgp - a mixture of proteinases and adhesins [ ]. These domains are cleaved from the original polyprotein and f... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF07675"
] | [
"Cleaved_Adhesin"
] | [
1210
] | 1 | [] | [] | [] | 0 | [
"3km5",
"3m1h",
"4itc"
] | 3 | [
"PUB00015190",
"PUB00015224"
] | [
"9245829",
"10858222"
] | [
"A cell-associated protein complex of Porphyromonas gingivalis W50 composed of Arg- and Lys-specific cysteine proteinases and adhesins.",
"RgpA-Kgp peptide-based immunogens provide protection against Porphyromonas gingivalis challenge in a murine lesion model."
] | [
1997,
2000
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
1181,
7,
22
] | 3 | [] | [] | 0 | true | Domain | Cleaved adhesin | Cleaved adhesin | Cleaved_adhesin | 8 |
IPR011630 | 11,630 | Nucleotide modification associated domain 1 | DUF1599 | Domain | 2,750 | false | false | This entry represents an α helical domain with conserved polar residues suggestive of enzymatic function. The domain is associated with the 5-hydroxymethyl uridine synthase and is predicted to play a role in modified base biosynthesis pathways [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF07659"
] | [
"DUF1599"
] | [
2750
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00091053"
] | [
"23814188"
] | [
"Computational identification of novel biochemical systems involved in oxidation, glycosylation and other complex modifications of bases in DNA."
] | [
2013
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Methanobacteriota",
"Viruses",
"metagenomes"
] | [
2548,
4,
7,
85,
106
] | 5 | [] | [] | 0 | true | Domain | Nucleotide modification associated domain 1 | Nucleotide modification associated domain 1 | DUF1599 | 4 |
IPR011631 | 11,631 | Protein of unknown function DUF1600 | DUF1600 | Family | 59 | false | false | These proteins appear to be specific to Mycoplasma species. They are of unknown function. | [] | [] | [] | 0 | [
"PFAM",
"PIRSF"
] | [
"PF07667",
"PIRSF006834"
] | [
"DUF1600",
"UCP006834"
] | [
59,
31
] | 2 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Mycoplasmatota"
] | [
59
] | 1 | [] | [] | 0 | true | Family | Protein of unknown function DUF1600 | Protein of unknown function DUF1600 | DUF1600 | 4 |
IPR011632 | 11,632 | Domain of unknown function DUF1601 | DUF1601 | Domain | 197 | false | false | This domain of unknown function is found repeated in a number of proteins. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF07671"
] | [
"DUF1601"
] | [
197
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Methanospirillum",
"Pseudomonadota"
] | [
153,
2,
42
] | 3 | [] | [] | 0 | true | Domain | Domain of unknown function DUF1601 | Domain of unknown function DUF1601 | DUF1601 | 4 |
IPR011635 | 11,635 | CARDB domain | CARDB | Domain | 7,667 | false | false | This entry represents a CARDB (cell adhesion related domain found in bacteria) domain contained in bacterial and archaeal proteins. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF07705"
] | [
"CARDB"
] | [
7667
] | 1 | [] | [] | [] | 0 | [
"2kl6",
"2kut",
"2l0d",
"2m8x",
"3idu"
] | 5 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Haloarcula vallismortis tailed virus 1",
"unclassified sequences"
] | [
2397,
4901,
54,
1,
314
] | 5 | [] | [] | 0 | true | Domain | CARDB domain | CARDB domain | CARDB | 9 |
IPR011636 | 11,636 | Thiosulphate:quinone oxidoreductase small subunit DoxA | DoxA | Domain | 741 | false | false | Thiosulphate:quinone oxidoreductase (TQO) catalyses one of the early steps in elemental sulphur oxidation. A novel TQO enzyme was purified from the thermo-acidophilic archaeon Acidianus ambivalens and shown to consist of a large subunit (DoxD) and a smaller subunit (DoxA). The DoxD- and DoxA-like two subunits are fused... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF07680"
] | [
"DoxA"
] | [
741
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Ceratobasidium theobromae",
"ecological metagenomes"
] | [
83,
648,
1,
9
] | 4 | [] | [] | 0 | true | Domain | Thiosulphate:quinone oxidoreductase small subunit DoxA | Thiosulphate:quinone oxidoreductase small subunit DoxA | DoxA | 2 |
IPR011638 | 11,638 | Sorbitol phosphotransferase enzyme II, C-terminal | PTS_EIIBC_GUT_C | Domain | 2,508 | false | false | The Gut family consists only of glucitol-specific permeases, but these occur both in Gram-negative and Gram-positive bacteria. Escherichia coli contains IIA protein, IIC protein and IIBC protein. This entry represents the C-terminal conserved region of the IIBC component. | [
"GO:0008982",
"GO:0009401",
"GO:0016020"
] | [
"protein-N(PI)-phosphohistidine-sugar phosphotransferase activity",
"phosphoenolpyruvate-dependent sugar phosphotransferase system",
"membrane"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PFAM"
] | [
"PF07663"
] | [
"EIIBC-GUT_C"
] | [
2508
] | 1 | [
"EC"
] | [
"2.7.1.198"
] | [
"EC:2.7.1.198"
] | 1 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Trichuris trichiura",
"metagenomes"
] | [
2498,
1,
9
] | 3 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Domain | Sorbitol phosphotransferase enzyme II, C-terminal | Sorbitol phosphotransferase enzyme II, C-terminal | PTS_EIIBC_GUT_C | 1 |
IPR011639 | 11,639 | Type II methyltransferase M.TaqI-like domain | MethylTrfase_TaqI-like_dom | Domain | 17,508 | false | false | This entry contains restriction modification methylases, including Type II methyltransferase M.TaqI from Thermus aquaticus. This protein is a gamma subtype methylase that recognises the double-stranded sequence 5'-TCGA-3', methylates A-4 on both strands and protects the DNA from cleavage by the TaqI endonuclease [ ]. | [
"GO:0006304"
] | [
"DNA modification"
] | [
"biological_process"
] | 1 | [
"PFAM"
] | [
"PF07669"
] | [
"Eco57I"
] | [
17508
] | 1 | [
"EC"
] | [
"2.1.1.72"
] | [
"EC:2.1.1.72"
] | 1 | [
"1aqi",
"1aqj",
"1g38",
"2adm",
"2ibs",
"2ibt",
"2ih2",
"2ih4",
"2ih5",
"2jg3",
"2np6",
"2np7",
"7lni",
"7lnj",
"7lt5",
"7qw5",
"7qw6",
"7qw7",
"7qw8",
"7rfk",
"7rfl",
"7rfm",
"7rfn",
"8c45",
"8cxs",
"8cxt",
"8cxu",
"8cxv",
"8cxw",
"8cxx",
"8cxy",
"8cxz"... | 48 | [
"PUB00019493",
"PUB00035709",
"PUB00035710",
"PUB00151915"
] | [
"1334261",
"15134658",
"11124947",
"2827113"
] | [
"Cloning and sequence analysis of the genes coding for Eco57I type IV restriction-modification enzymes.",
"Crystallization and preliminary crystallographic studies of a bifunctional restriction endonuclease Eco57I.",
"Mutational analysis of two putative catalytic motifs of the type IV restriction endonuclease E... | [
1992,
2004,
2001,
1987
] | 4 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
1003,
15630,
178,
115,
582
] | 5 | [] | [] | 0 | true | Domain | Type II methyltransferase M.TaqI-like domain | Type II methyltransferase M.TaqI-like domain | MethylTrfase_TaqI-like_dom | 4 |
IPR011641 | 11,641 | Tyrosine-protein kinase ephrin type A/B receptor-like | Tyr-kin_ephrin_A/B_rcpt-like | Domain | 28,805 | false | false | This entry represents a domain found in various ephrin type A and B receptors, which have tyrosine kinase activity. Protein phosphorylation, which plays a key role in most cellular activities, is a reversible process mediated by protein kinases and phosphoprotein phosphatases. Protein kinases catalyse the transfer of t... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF07699"
] | [
"Ephrin_rec_like"
] | [
28805
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-DRE-5362798",
"R-GGA-2682334",
"R-GGA-3928663",
"R-GGA-3928665",
"R-HSA-1474228",
"R-HSA-2682334",
"R-HSA-2892247",
"R-HSA-373760",
"R-HSA-3928662",
"R-HSA-3928663",
"R-HSA-3928664",
"R-HSA-3928665",
"R-HSA-5362798",
"R-MMU-1474228",
"R-MMU-2682334",
"R-MMU-3928662",
"R-MMU-392866... | [
"REACTOME:R-DRE-5362798",
"REACTOME:R-GGA-2682334",
"REACTOME:R-GGA-3928663",
"REACTOME:R-GGA-3928665",
"REACTOME:R-HSA-1474228",
"REACTOME:R-HSA-2682334",
"REACTOME:R-HSA-2892247",
"REACTOME:R-HSA-373760",
"REACTOME:R-HSA-3928662",
"REACTOME:R-HSA-3928663",
"REACTOME:R-HSA-3928664",
"REACTOME... | 25 | [
"4bk4",
"4bk5",
"4bka",
"4bkf",
"4m4p",
"4m4r",
"6scj",
"7b75",
"7k7j",
"7n4y",
"7qtq",
"7s7k",
"8tx1",
"8txb",
"8txc",
"8wa2",
"9b4h"
] | 17 | [
"PUB00005115",
"PUB00015362",
"PUB00020114",
"PUB00034898",
"PUB00034899",
"PUB00052410",
"PUB00052411",
"PUB00052412"
] | [
"3291115",
"12368087",
"12471243",
"15078142",
"15320712",
"19275641",
"16700535",
"15845350"
] | [
"The protein kinase family: conserved features and deduced phylogeny of the catalytic domains.",
"Evolution of protein kinase signaling from yeast to man.",
"The protein kinase complement of the human genome.",
"High-throughput structural biology in drug discovery: protein kinases.",
"Creating chemical dive... | [
1988,
2002,
2002,
2004,
2004,
2009,
2006,
2005
] | 8 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Methanobacteriati",
"Pyramimonas orientalis virus 01B",
"metagenomes"
] | [
14,
28768,
15,
1,
7
] | 5 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
4,
77,
3,
50,
43,
51
] | 6 | true | Domain | Tyrosine-protein kinase ephrin type A/B receptor-like | Tyrosine-protein kinase ephrin type A/B receptor-like | Tyr-kin_ephrin_A/B_rcpt-like | 6 |
IPR011642 | 11,642 | Nucleoside transporter/FeoB GTPase, Gate domain | Gate_dom | Domain | 55,071 | false | false | This domain is responsible for determining nucleoside specificity in the human sodium/nucleoside cotransporter proteins CNT1 and CNT2 (e.g. ) [ ]. In the FeoB proteins (e.g. ), which are believed to be Fe 2+ transporters, it includes the membrane pore region, so the function of this domain is likely to be more general ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF07670"
] | [
"Gate"
] | [
55071
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-83936",
"R-HSA-9638482",
"R-HSA-9748787",
"R-HSA-9755088",
"R-MMU-83936",
"R-MMU-9748787",
"R-MMU-9755088",
"R-RNO-83936",
"R-RNO-9748787",
"R-RNO-9755088"
] | [
"REACTOME:R-HSA-83936",
"REACTOME:R-HSA-9638482",
"REACTOME:R-HSA-9748787",
"REACTOME:R-HSA-9755088",
"REACTOME:R-MMU-83936",
"REACTOME:R-MMU-9748787",
"REACTOME:R-MMU-9755088",
"REACTOME:R-RNO-83936",
"REACTOME:R-RNO-9748787",
"REACTOME:R-RNO-9755088"
] | 10 | [
"3tij",
"4pb1",
"4pb2",
"4pd5",
"4pd6",
"4pd7",
"4pd8",
"4pd9",
"4pda",
"5l24",
"5l26",
"5l27",
"5l2a",
"5l2b",
"5u9w",
"6ksw",
"8tz1",
"8tz2",
"8tz3",
"8tz4",
"8tz5",
"8tz6",
"8tz7",
"8tz8",
"8tz9",
"8tza",
"8tzd"
] | 27 | [
"PUB00015192",
"PUB00015207"
] | [
"10455109",
"12781516"
] | [
"Identification of amino acid residues responsible for the pyrimidine and purine nucleoside specificities of human concentrative Na(+) nucleoside cotransporters hCNT1 and hCNT2.",
"Is the bacterial ferrous iron transporter FeoB a living fossil?"
] | [
1999,
2003
] | 2 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified Caudoviricetes",
"unclassified sequences"
] | [
935,
48214,
5216,
2,
704
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus"
] | [
1,
2,
4,
5,
6,
9,
5,
1,
15
] | 9 | true | Domain | Nucleoside transporter/FeoB GTPase, Gate domain | Nucleoside transporter/FeoB GTPase, Gate domain | Gate_dom | 9 |
IPR011644 | 11,644 | Heme NO-binding | Heme_NO-bd | Domain | 9,449 | false | false | The HNOB (Haem NO Binding) domain is a predominantly α-helical domain and binds heme via a covalent linkage to histidine [ ]. This domain is found in soluble guanylate cyclases, which are nitric oxide-responsive signaling proteins. It is predicted to function as a haem-dependent sensor for gaseous ligands and to transd... | [
"GO:0020037"
] | [
"heme binding"
] | [
"molecular_function"
] | 1 | [
"PFAM"
] | [
"PF07700"
] | [
"HNOB"
] | [
9449
] | 1 | [
"EC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"4.6.1.2",
"R-BTA-445355",
"R-CFA-445355",
"R-DME-445355",
"R-HSA-392154",
"R-HSA-445355",
"R-MMU-445355",
"R-RNO-445355"
] | [
"EC:4.6.1.2",
"REACTOME:R-BTA-445355",
"REACTOME:R-CFA-445355",
"REACTOME:R-DME-445355",
"REACTOME:R-HSA-392154",
"REACTOME:R-HSA-445355",
"REACTOME:R-MMU-445355",
"REACTOME:R-RNO-445355"
] | 8 | [
"1u4h",
"1u55",
"1u56",
"1xbn",
"2kii",
"2kil",
"2o09",
"2o0c",
"2o0g",
"3eee",
"3iqb",
"3l6j",
"3lah",
"3lai",
"3m0b",
"3nvr",
"3nvu",
"3sj5",
"3tf0",
"3tf1",
"3tf8",
"3tf9",
"3tfa",
"3tfd",
"3tfe",
"3tff",
"3tfg",
"4fdk",
"4iae",
"4iah",
"4iam",
"4it2"... | 69 | [
"PUB00019713",
"PUB00032379"
] | [
"12590654",
"15472039"
] | [
"Ancient conserved domains shared by animal soluble guanylyl cyclases and bacterial signaling proteins.",
"Femtomolar sensitivity of a NO sensor from Clostridium botulinum."
] | [
2003,
2004
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Stenosarchaea group",
"ecological metagenomes"
] | [
2727,
6599,
103,
20
] | 4 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
9,
8,
10,
10,
10,
24
] | 6 | true | Domain | Heme NO-binding | Heme NO-binding | Heme_NO-bd | 3 |
IPR011646 | 11,646 | KAP family P-loop domain | KAP_P-loop | Domain | 13,208 | false | false | The KAP (after Kidins220/ARMS and PifA) family of predicted NTPases are sporadically distributed across a wide phylogenetic range in bacteria and in animals. Many of the prokaryotic KAP NTPases are encoded in plasmids and tend to undergo disruption to form pseudogenes. A unique feature of all eukaryotic and certain bac... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF07693"
] | [
"KAP_NTPase"
] | [
13208
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-DRE-170984",
"R-DRE-9696270",
"R-DRE-9696273",
"R-HSA-170984",
"R-HSA-9696270",
"R-HSA-9696273",
"R-RNO-170984",
"R-RNO-9696270",
"R-RNO-9696273"
] | [
"REACTOME:R-DRE-170984",
"REACTOME:R-DRE-9696270",
"REACTOME:R-DRE-9696273",
"REACTOME:R-HSA-170984",
"REACTOME:R-HSA-9696270",
"REACTOME:R-HSA-9696273",
"REACTOME:R-RNO-170984",
"REACTOME:R-RNO-9696270",
"REACTOME:R-RNO-9696273"
] | 9 | [
"8fnu"
] | 1 | [
"PUB00015187"
] | [
"15128444"
] | [
"A novel family of P-loop NTPases with an unusual phyletic distribution and transmembrane segments inserted within the NTPase domain."
] | [
2004
] | 1 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"metagenomes"
] | [
155,
7689,
5239,
7,
118
] | 5 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
8,
20,
17,
1,
18,
12,
19
] | 7 | true | Domain | KAP family P-loop domain | KAP family P-loop domain | KAP_P-loop | 2 |
IPR011648 | 11,648 | Circadian clock oscillator protein KaiA | Circadian_clock_KaiA | Family | 380 | false | false | KaiA is a component of the the KaiABC oscillator complex, which constitutes the main circadian regulator in cyanobacteria [ ]. The kaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction. In the complex, KaiA enhance... | [
"GO:0006468",
"GO:0007623"
] | [
"protein phosphorylation",
"circadian rhythm"
] | [
"biological_process",
"biological_process"
] | 2 | [
"SMART"
] | [
"SM01247"
] | [
"KaiA"
] | [
380
] | 1 | [] | [] | [] | 0 | [
"1m2e",
"1m2f",
"1q6a",
"1q6b",
"1r5q",
"1r8j",
"1suy",
"1sv1",
"1v2z",
"4g86",
"5c5e",
"5jwr",
"5n8y"
] | 13 | [
"PUB00014089",
"PUB00015216",
"PUB00031979",
"PUB00103685",
"PUB00103686",
"PUB00103687"
] | [
"12438647",
"15071498",
"15170179",
"28302852",
"17717528",
"17916691"
] | [
"Structure and function from the circadian clock protein KaiA of Synechococcus elongatus: a potential clock input mechanism.",
"Anabaena circadian clock proteins KaiA and KaiB reveal a potential common binding site to their partner KaiC.",
"Crystal structure of the C-terminal clock-oscillator domain of the cyan... | [
2002,
2004,
2004,
2017,
2007,
2007
] | 6 | [] | [] | 0 | 0 | null | [
"Bacteria"
] | [
380
] | 1 | [] | [] | 0 | true | Family | Circadian clock oscillator protein KaiA | Circadian clock oscillator protein KaiA | Circadian_clock_KaiA | 1 |
IPR011650 | 11,650 | Peptidase M20, dimerisation domain | Peptidase_M20_dimer | Domain | 204,057 | false | false | This domain consists of 4 β-strands and two α-helices which make up the dimerisation surface of members of the MEROPS peptidase family M20 [ ]. This family includes a range of zinc exopeptidases: carboxypeptidases, dipeptidases and specialised aminopeptidases [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF07687"
] | [
"M20_dimer"
] | [
204057
] | 1 | [
"EC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
... | [
"3.5.1",
"R-BTA-174403",
"R-BTA-9753281",
"R-DDI-5423646",
"R-DDI-9673163",
"R-DDI-9753281",
"R-DRE-9673163",
"R-HSA-174403",
"R-HSA-5423646",
"R-HSA-5579007",
"R-HSA-9673163",
"R-HSA-9753281",
"R-MMU-174403",
"R-MMU-5423646",
"R-MMU-9673163",
"R-MMU-9753281",
"R-RNO-174403",
"R-RN... | [
"EC:3.5.1",
"REACTOME:R-BTA-174403",
"REACTOME:R-BTA-9753281",
"REACTOME:R-DDI-5423646",
"REACTOME:R-DDI-9673163",
"REACTOME:R-DDI-9753281",
"REACTOME:R-DRE-9673163",
"REACTOME:R-HSA-174403",
"REACTOME:R-HSA-5423646",
"REACTOME:R-HSA-5579007",
"REACTOME:R-HSA-9673163",
"REACTOME:R-HSA-9753281"... | 28 | [
"1cg2",
"1fno",
"1r3n",
"1r43",
"1vgy",
"1vix",
"1xmb",
"1ysj",
"2f7v",
"2f8h",
"2pok",
"2q43",
"2qyv",
"2rb7",
"2v8d",
"2v8g",
"2v8h",
"2v8v",
"2vl1",
"2zof",
"2zog",
"3ct9",
"3dlj",
"3gb0",
"3ic1",
"3ife",
"3io1",
"3isz",
"3mru",
"3n5f",
"3pfe",
"3pfo"... | 73 | [
"PUB00003579",
"PUB00015203"
] | [
"7674922",
"9083113"
] | [
"Evolutionary families of metallopeptidases.",
"Crystal structure of carboxypeptidase G2, a bacterial enzyme with applications in cancer therapy."
] | [
1995,
1997
] | 2 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
3805,
167633,
30344,
4,
2271
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
48,
8,
11,
12,
7,
18,
11,
5,
26,
19,
4,
3,
35
] | 13 | true | Domain | Peptidase M20, dimerisation domain | Peptidase M20, dimerisation domain | Peptidase_M20_dimer | 5 |
IPR011651 | 11,651 | Notch ligand, N-terminal domain | Notch_ligand_N | Domain | 7,906 | false | false | This entry represents a region of conserved sequence at the N terminus of several Notch ligand proteins, including Delta-like protein 1 (DLL1), 4 (DLL4) and Protein jagged-1. It plays a role in lipid binding [ , , ]. | [
"GO:0007219",
"GO:0007275",
"GO:0016020"
] | [
"Notch signaling pathway",
"multicellular organism development",
"membrane"
] | [
"biological_process",
"biological_process",
"cellular_component"
] | 3 | [
"PFAM"
] | [
"PF07657"
] | [
"MNNL"
] | [
7906
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-DME-1912420",
"R-DME-2979096",
"R-DME-9013700",
"R-DME-9604323",
"R-DRE-2979096",
"R-HSA-2122948",
"R-HSA-2644606",
"R-HSA-2660826",
"R-HSA-2691232",
"R-HSA-2894862",
"R-HSA-2979096",
"R-HSA-8941856",
"R-HSA-9013149",
"R-HSA-9013423",
"R-HSA-9013507",
"R-HSA-9013700",
"R-HSA-90227... | [
"REACTOME:R-DME-1912420",
"REACTOME:R-DME-2979096",
"REACTOME:R-DME-9013700",
"REACTOME:R-DME-9604323",
"REACTOME:R-DRE-2979096",
"REACTOME:R-HSA-2122948",
"REACTOME:R-HSA-2644606",
"REACTOME:R-HSA-2660826",
"REACTOME:R-HSA-2691232",
"REACTOME:R-HSA-2894862",
"REACTOME:R-HSA-2979096",
"REACTOM... | 29 | [
"4cbz",
"4cc0",
"4cc1",
"4xbm",
"4xl1",
"4xlw",
"5mvx",
"5mw5",
"5mw7",
"5mwf",
"5uk5",
"7alk",
"7alt"
] | 13 | [
"PUB00075562",
"PUB00075563",
"PUB00101181"
] | [
"25715738",
"25700513",
"24239355"
] | [
"Notch ligand delta-like1: X-ray crystal structure and binding affinity.",
"Structural biology. Structural basis for Notch1 engagement of Delta-like 4.",
"Structural analysis uncovers lipid-binding properties of Notch ligands."
] | [
2015,
2015,
2013
] | 3 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
7906
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
20,
3,
11,
8,
23
] | 5 | true | Domain | Notch ligand, N-terminal domain | Notch ligand, N-terminal domain | Notch_ligand_N | 9 |
IPR011652 | 11,652 | MORN variant | MORN_2 | Repeat | 9,853 | false | false | This entry represents an apparent variant of the repeat. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF07661"
] | [
"MORN_2"
] | [
9853
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Stenosarchaea group",
"Viruses",
"unclassified sequences"
] | [
9271,
36,
2,
61,
483
] | 5 | [] | [] | 0 | true | Repeat | MORN variant | MORN variant | MORN_2 | 2 |
IPR011653 | 11,653 | Lipoprotein protein 35 | Lipoprotein_p35 | Family | 79 | false | false | This group of paralogous proteins identified in Mycoplasma penetrans includes homologues of lipoprotein p35 [ ]. | [
"GO:0016020"
] | [
"membrane"
] | [
"cellular_component"
] | 1 | [
"PFAM"
] | [
"PF07668"
] | [
"MpPF1"
] | [
79
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00015196"
] | [
"12466555"
] | [
"The complete genomic sequence of Mycoplasma penetrans, an intracellular bacterial pathogen in humans."
] | [
2002
] | 1 | [] | [] | 0 | 0 | null | [
"Malacoplasma"
] | [
79
] | 1 | [] | [] | 0 | true | Family | Lipoprotein protein 35 | Lipoprotein protein 35 | Lipoprotein_p35 | 4 |
IPR011655 | 11,655 | M penetrans paralogue 26 | MpPF26 | Family | 758 | false | false | These proteins include those ascribed to M penetrans paralogue family 26 in [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF07666"
] | [
"MpPF26"
] | [
758
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00015196"
] | [
"12466555"
] | [
"The complete genomic sequence of Mycoplasma penetrans, an intracellular bacterial pathogen in humans."
] | [
2002
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"ecological metagenomes"
] | [
752,
6
] | 2 | [] | [] | 0 | true | Family | M penetrans paralogue 26 | M penetrans paralogue 26 | MpPF26 | 9 |
IPR011656 | 11,656 | Notch, NODP domain | Notch_NODP_dom | Domain | 5,501 | false | false | NOTCH signalling plays a fundamental role during a great number of developmental processes in multicellular animals [ ]. NOD and NODP represent a region present in many NOTCH proteins and NOTCH homologues in multiple species such as NOTCH2 and NOTCH3, LIN12, SC1 and TAN1. The role of the NOD and NODP domains remains to... | [
"GO:0007219",
"GO:0007275",
"GO:0030154",
"GO:0016020"
] | [
"Notch signaling pathway",
"multicellular organism development",
"cell differentiation",
"membrane"
] | [
"biological_process",
"biological_process",
"biological_process",
"cellular_component"
] | 4 | [
"PFAM",
"SMART"
] | [
"PF07684",
"SM01339"
] | [
"NODP",
"NODP"
] | [
5484,
5371
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-CEL-1912420",
"R-CEL-9013700",
"R-CEL-9604323",
"R-HSA-1912399",
"R-HSA-1912408",
"R-HSA-1912420",
"R-HSA-210744",
"R-HSA-2122947",
"R-HSA-2122948",
"R-HSA-2197563",
"R-HSA-2644606",
"R-HSA-2644607",
"R-HSA-2660826",
"R-HSA-2691232",
"R-HSA-2894862",
"R-HSA-2979096",
"R-HSA-350054... | [
"REACTOME:R-CEL-1912420",
"REACTOME:R-CEL-9013700",
"REACTOME:R-CEL-9604323",
"REACTOME:R-HSA-1912399",
"REACTOME:R-HSA-1912408",
"REACTOME:R-HSA-1912420",
"REACTOME:R-HSA-210744",
"REACTOME:R-HSA-2122947",
"REACTOME:R-HSA-2122948",
"REACTOME:R-HSA-2197563",
"REACTOME:R-HSA-2644606",
"REACTOME... | 48 | [
"2oo4",
"3eto",
"3i08",
"3l95",
"4zlp",
"5czv",
"5czx",
"6xsw",
"7abv"
] | 9 | [
"PUB00013432"
] | [
"10221902"
] | [
"Notch signaling: cell fate control and signal integration in development."
] | [
1999
] | 1 | [] | [] | 0 | 0 | null | [
"Eumetazoa",
"Feline leukemia virus"
] | [
5497,
4
] | 2 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
9,
3,
34,
6,
20
] | 6 | true | Domain | Notch, NODP domain | Notch, NODP domain | Notch_NODP_dom | 6 |
IPR011657 | 11,657 | Concentrative nucleoside transporter C-terminal domain | CNT_C_dom | Domain | 18,770 | false | false | The concentrative nucleoside transporter (CNT) (TC 2.A.41) family includes , which is a purine-specific Na + -nucleoside cotransporter localised to the bile canalicular membrane [ ]. It also includes , a Na + -dependent nucleoside transporter selective for pyrimidine nucleosides and adenosine, which also transports the... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF07662"
] | [
"Nucleos_tra2_C"
] | [
18770
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-83936",
"R-HSA-9748787",
"R-HSA-9755088",
"R-MMU-83936",
"R-MMU-9748787",
"R-MMU-9755088",
"R-RNO-83936",
"R-RNO-9748787",
"R-RNO-9755088"
] | [
"REACTOME:R-HSA-83936",
"REACTOME:R-HSA-9748787",
"REACTOME:R-HSA-9755088",
"REACTOME:R-MMU-83936",
"REACTOME:R-MMU-9748787",
"REACTOME:R-MMU-9755088",
"REACTOME:R-RNO-83936",
"REACTOME:R-RNO-9748787",
"REACTOME:R-RNO-9755088"
] | 9 | [
"3tij",
"4pb1",
"4pb2",
"4pd5",
"4pd6",
"4pd7",
"4pd8",
"4pd9",
"4pda",
"5l24",
"5l26",
"5l27",
"5l2a",
"5l2b",
"5u9w",
"6ksw",
"8tz1",
"8tz2",
"8tz3",
"8tz4",
"8tz5",
"8tz6",
"8tz7",
"8tz8",
"8tz9",
"8tza",
"8tzd"
] | 27 | [
"PUB00002855",
"PUB00002907"
] | [
"8027026",
"7775409"
] | [
"Cloning and functional expression of a complementary DNA encoding a mammalian nucleoside transport protein.",
"Primary structure and functional expression of a cDNA encoding the bile canalicular, purine-specific Na(+)-nucleoside cotransporter."
] | [
1994,
1995
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Musca hytrovirus(isolate Musca domestica/United States/Boucias/-)",
"metagenomes"
] | [
12937,
5723,
1,
109
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus"
] | [
1,
4,
4,
5,
3,
9,
5,
1,
15
] | 9 | true | Domain | Concentrative nucleoside transporter C-terminal domain | Concentrative nucleoside transporter C-terminal domain | CNT_C_dom | 1 |
IPR011658 | 11,658 | PA14 domain | PA14_dom | Domain | 22,828 | false | false | The PA14 domain forms an insert in bacterial beta-glucosidases, other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins and bacterial toxins, including anthrax protective antigen (PA). The domain also occurs in a Dictyostelium pre-spore cell-inducing factor Psi and in fibrocystin, the mammalian pr... | [] | [] | [] | 0 | [
"PFAM",
"SMART"
] | [
"PF07691",
"SM00758"
] | [
"PA14",
"PA14"
] | [
21341,
18783
] | 2 | [
"REACTOME"
] | [
"R-HSA-5210891"
] | [
"REACTOME:R-HSA-5210891"
] | 1 | [
"1acc",
"1t6b",
"2j42",
"2xjp",
"2xjq",
"2xjr",
"2xjs",
"2xjt",
"2xju",
"2xjv",
"2xvg",
"2xvk",
"2xvl",
"3abz",
"3ac0",
"3mhz",
"3q8a",
"3q8b",
"3q8c",
"3q8e",
"3q8f",
"3tew",
"3tex",
"3tey",
"3tez",
"4ahw",
"4ahx",
"4ahy",
"4ahz",
"4ai0",
"4ai1",
"4ai2"... | 74 | [
"PUB00017237"
] | [
"15236739"
] | [
"The PA14 domain, a conserved all-beta domain in bacterial toxins, enzymes, adhesins and signaling molecules."
] | [
2004
] | 1 | [
"IPR037524"
] | [] | 1 | 0 | 1 | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
62,
13425,
9121,
20,
200
] | 5 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
10,
6,
6,
1,
8,
7,
1
] | 7 | true | Domain | PA14 domain | PA14 domain | PA14_dom | 8 |
IPR011659 | 11,659 | WD40-like beta-propeller | WD40 | Repeat | 61,978 | false | false | This region appears to be related to the repeat. This model is likely to miss copies within a sequence. WD-40 repeats (also known as WD or beta-transducin repeats) are short ~40 amino acid motifs, often terminating in a Trp-Asp (W-D) dipeptide. WD40 repeats usually assume a 7-8 bladed β-propeller fold, but proteins hav... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF07676"
] | [
"PD40"
] | [
61978
] | 1 | [] | [] | [] | 0 | [
"1c5k",
"1crz",
"2gop",
"2hqs",
"2ivz",
"2ojh",
"2w8b",
"3iax",
"4hxe",
"4hxf",
"4hxg",
"4jml",
"4pwz",
"4r40",
"5yzm",
"5yzn",
"5yzo",
"6igp",
"6igq",
"6igr",
"6ikg",
"6pnv",
"7mx5",
"7nst",
"7nsu",
"8wt1"
] | 26 | [
"PUB00005491",
"PUB00015237",
"PUB00094364"
] | [
"10322433",
"11814058",
"30069656"
] | [
"The WD repeat: a common architecture for diverse functions.",
"WD-repeat proteins: structure characteristics, biological function, and their involvement in human diseases.",
"WD40 Repeat Proteins: Signalling Scaffold with Diverse Functions."
] | [
1999,
2001,
2018
] | 3 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
1015,
54847,
4830,
2,
1284
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Escherichia coli (strain K12)",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
13,
5,
2,
1,
15,
11
] | 6 | true | Repeat | WD40-like beta-propeller | WD40-like beta-propeller | WD40 | 5 |
IPR011660 | 11,660 | Antitoxin VapB-like | VapB-like | Family | 2,336 | false | false | This entry includes a group of antitoxins, including vapB from Mycobacterium smegmatis. VapB is an antitoxin component of a type II toxin-antitoxin (TA) module that controls growth via inhibition of translation [ , ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF07704"
] | [
"PSK_trans_fac"
] | [
2336
] | 1 | [] | [] | [] | 0 | [
"4xgq",
"4xgr"
] | 2 | [
"PUB00084344",
"PUB00084345"
] | [
"19445953",
"25047537"
] | [
"The vapBC operon from Mycobacterium smegmatis is an autoregulated toxin-antitoxin module that controls growth via inhibition of translation.",
"VapC from the leptospiral VapBC toxin-antitoxin module displays ribonuclease activity on the initiator tRNA."
] | [
2009,
2014
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Geodia barretti",
"metagenomes"
] | [
2307,
3,
26
] | 3 | [] | [] | 0 | true | Family | Antitoxin VapB-like | Antitoxin VapB-like | VapB-like | 1 |
IPR011661 | 11,661 | Sulphur oxygenase reductase | S_Oase_red | Family | 85 | false | false | The crystal structure of the sulphur oxygenase/reductase (SOR) of the thermo-acidophilic archaeon Acidianus ambivalens has been determined to 1.7-A resolution [ ]. Twenty-four monomers form a large hollow sphere enclosing a positively charged nanocompartment. Apolar channels provide access for linear sulphur species. A... | [] | [] | [] | 0 | [
"NCBIFAM",
"PFAM"
] | [
"NF047630",
"PF07682"
] | [
"SulOxRed",
"SOR"
] | [
37,
85
] | 2 | [] | [] | [] | 0 | [
"2cb2",
"2yav",
"2yaw",
"2yax",
"3bxv",
"6m35",
"6m3x",
"6qjc",
"6qka",
"6qkm",
"6qmv",
"6qne",
"6qo0",
"6qpa",
"7x9w"
] | 15 | [
"PUB00020358",
"PUB00027805",
"PUB00047174"
] | [
"15030315",
"16484493",
"1522063"
] | [
"The sulphur oxygenase reductase from Acidianus ambivalens is a multimeric protein containing a low-potential mononuclear non-haem iron centre.",
"X-ray Structure of a self-compartmentalizing sulfur cycle metalloenzyme.",
"Molecular characterization of the sor gene, which encodes the sulfur oxygenase/reductase ... | [
2004,
2006,
1992
] | 3 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"marine sediment metagenome"
] | [
26,
58,
1
] | 3 | [] | [] | 0 | true | Family | Sulphur oxygenase reductase | Sulphur oxygenase reductase | S_Oase_red | 3 |
IPR011662 | 11,662 | Secretin/TonB, short N-terminal domain | Secretin/TonB_short_N | Domain | 40,657 | false | false | This is a short domain found at the N terminus of the Secretins of the bacterial type II/III secretory system, as well as the TonB-dependent receptor proteins. These proteins are involved in TonB-dependent active uptake of selective substrates. | [
"GO:0019867"
] | [
"outer membrane"
] | [
"cellular_component"
] | 1 | [
"PFAM",
"SMART"
] | [
"PF07660",
"SM00965"
] | [
"STN",
"STN"
] | [
28888,
38063
] | 2 | [
"REACTOME"
] | [
"R-HSA-9638482"
] | [
"REACTOME:R-HSA-9638482"
] | 1 | [
"1kmo",
"1kmp",
"1pnz",
"1po0",
"1po3",
"1zzv",
"2a02",
"2d1u",
"2iah",
"2m5j",
"2o5p",
"2w16",
"2w6t",
"2w6u",
"2w75",
"2w76",
"2w77",
"2w78",
"3csl",
"3csn",
"3ddr",
"3jc8",
"3jc9",
"4ar0",
"4av2",
"5c58",
"5odw",
"6i97",
"6ovk",
"6ovm",
"6ve2",
"6ve3"... | 42 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Siphoviridae sp. ctfeV1",
"unclassified sequences"
] | [
40072,
46,
1,
538
] | 4 | [
"Escherichia coli (strain K12)"
] | [
2
] | 1 | true | Domain | Secretin/TonB, short N-terminal domain | Secretin/TonB, short N-terminal domain | Secretin/TonB_short_N | 1 |
IPR011663 | 11,663 | UbiC transcription regulator-associated | UTRA | Domain | 75,302 | false | false | The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain that has a similar fold to [ ]. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules (sugar phosphates and urocanate, [ , ]. Proteins containing this domain include the... | [
"GO:0003677",
"GO:0006355"
] | [
"DNA binding",
"regulation of DNA-templated transcription"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PFAM",
"SMART"
] | [
"PF07702",
"SM00866"
] | [
"UTRA",
"UTRA"
] | [
75254,
73656
] | 2 | [] | [] | [] | 0 | [
"2fa1",
"2ikk",
"2ogg",
"2ooi",
"2p19",
"2pkh",
"2ra5",
"2wv0",
"3bwg",
"3cnv",
"3ddv",
"3edp",
"3eet",
"3f8l",
"3f8m",
"3hfi",
"3l5z",
"3lhe",
"4u0v",
"4u0w",
"4wwc",
"4zs8",
"4zsb",
"4zsi",
"4zsk"
] | 25 | [
"PUB00015204",
"PUB00067926",
"PUB00099685"
] | [
"12757941",
"2203754",
"34424339"
] | [
"HutC/FarR-like bacterial transcription factors of the GntR family contain a small molecule-binding domain of the chorismate lyase fold.",
"Nucleotide sequence of the gene encoding the repressor for the histidine utilization genes of Klebsiella aerogenes.",
"A catalogue of signal molecules that interact with se... | [
2003,
1990,
2021
] | 3 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Streptomyces phage ZL12",
"unclassified sequences"
] | [
5,
74905,
30,
1,
361
] | 5 | [
"Escherichia coli (strain K12)"
] | [
6
] | 1 | true | Domain | UbiC transcription regulator-associated | UbiC transcription regulator-associated | UTRA | 4 |
IPR011664 | 11,664 | Abortive infection system protein AbiD/AbiF-like | Abi_system_AbiD/AbiF-like | Family | 6,039 | false | false | Bacteria have numerous mechanisms to resist bacteriophage infection. While most are based on preventing infection in the first place, the abortive infection (Abi) systems provide protection by the abortion of an existing phage infection [ ]. Typically, these Abi systems target a crucial step of phage multiplication suc... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF07751"
] | [
"Abi_2"
] | [
6039
] | 1 | [] | [] | [] | 0 | [
"8vz6"
] | 1 | [
"PUB00015191",
"PUB00015230",
"PUB00015231",
"PUB00056243"
] | [
"8534099",
"7601849",
"7601848",
"20348932"
] | [
"Cloning and DNA sequence analysis of two abortive infection phage resistance determinants from the lactococcal plasmid pNP40.",
"Phage operon involved in sensitivity to the Lactococcus lactis abortive infection mechanism AbiD1.",
"Characterization of the lactococcal abiD1 gene coding for phage abortive infecti... | [
1995,
1995,
1995,
2010
] | 4 | [] | [
"IPR017034"
] | 0 | 1 | 0 | [
"Bacteria",
"Eukaryota",
"Methanosarcinaceae",
"Viruses",
"unclassified sequences"
] | [
5942,
5,
16,
31,
45
] | 5 | [] | [] | 0 | true | Family | Abortive infection system protein AbiD/AbiF-like | Abortive infection system protein AbiD/AbiF-like | Abi_system_AbiD/AbiF-like | 2 |
IPR011665 | 11,665 | Brf1, TBP-binding domain | BRF1_TBP-bd_dom | Domain | 5,681 | false | false | In budding yeasts, Brf1 forms the TFIIIB complex with TATA-binding protein (TBP) and Bdp1 [ ]. The TFIIIB complex can be recruited to the Pol III promoters and form an exceptionally kinetically stable TFIIIB-DNA complex, which then recruits the Pol III enzymatic complex and helps maintain it for multiple transcription ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF07741"
] | [
"BRF1"
] | [
5681
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-749476",
"R-HSA-76061",
"R-HSA-76066",
"R-MMU-76061",
"R-MMU-76066",
"R-SCE-76066",
"R-SPO-76061",
"R-SPO-76066"
] | [
"REACTOME:R-HSA-749476",
"REACTOME:R-HSA-76061",
"REACTOME:R-HSA-76066",
"REACTOME:R-MMU-76061",
"REACTOME:R-MMU-76066",
"REACTOME:R-SCE-76066",
"REACTOME:R-SPO-76061",
"REACTOME:R-SPO-76066"
] | 8 | [
"1ngm",
"6cnb",
"6cnc",
"6cnd",
"6cnf",
"6eu0",
"6f40",
"6f41",
"6f42",
"6f44",
"7q5b",
"8ffz"
] | 12 | [
"PUB00015234",
"PUB00070391",
"PUB00070392"
] | [
"12660736",
"24277937",
"24336746"
] | [
"Crystal structure of a transcription factor IIIB core interface ternary complex.",
"Mapping the protein interaction network for TFIIB-related factor Brf1 in the RNA polymerase III preinitiation complex.",
"Intergenic transcriptional interference is blocked by RNA polymerase III transcription factor TFIIIB in S... | [
2003,
2014,
2014
] | 3 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
5681
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
29,
2,
7,
3,
3,
3,
1,
2,
3,
1,
1,
38
] | 12 | true | Domain | Brf1, TBP-binding domain | Brf1, TBP-binding domain | BRF1_TBP-bd_dom | 4 |
IPR011666 | 11,666 | G patch domain-containing protein, N-terminal | DUF1604 | Domain | 4,150 | false | false | This domain is found at the N-terminal of several eukaryotic RNA processing proteins, including Arabidopsis TGH, which is involved in microRNA (miRNA) and small interfering RNA (siRNA) biogenesis [ ]. | [
"GO:0006397"
] | [
"mRNA processing"
] | [
"biological_process"
] | 1 | [
"PFAM"
] | [
"PF07713"
] | [
"DUF1604"
] | [
4150
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-CEL-72163",
"R-DME-72163",
"R-HSA-72163",
"R-MMU-72163",
"R-SPO-72163"
] | [
"REACTOME:R-CEL-72163",
"REACTOME:R-DME-72163",
"REACTOME:R-HSA-72163",
"REACTOME:R-MMU-72163",
"REACTOME:R-SPO-72163"
] | 5 | [
"9esh",
"9esi",
"9l5s",
"9l5t"
] | 4 | [
"PUB00077126"
] | [
"22802657"
] | [
"Regulation of miRNA abundance by RNA binding protein TOUGH in Arabidopsis."
] | [
2012
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
4150
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Schizosaccharomyces pombe (stra... | [
5,
1,
2,
1,
4,
4,
1,
1,
6,
1,
6
] | 11 | true | Domain | G patch domain-containing protein, N-terminal | G patch domain-containing protein, N-terminal | DUF1604 | 2 |
IPR011667 | 11,667 | Uncharacterised protein family UPF0329 | UPF0329 | Family | 93 | false | false | This region is found in a number of hypothetical proteins thought to be expressed by the eukaryote Encephalitozoon cuniculi, an obligate intracellular microsporidial parasite. The proteins are approximately 200 residues long. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF07753"
] | [
"DUF1609"
] | [
93
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Candidatus Cardinium hertigii",
"Microsporidia"
] | [
3,
90
] | 2 | [] | [] | 0 | true | Family | Uncharacterised protein family UPF0329 | Uncharacterised protein family UPF0329 | UPF0329 | 7 |
IPR011668 | 11,668 | Ribosomal protein aS21, zinc-binding pocket | Ribosomal_aS21_ZBP | Domain | 779 | false | false | This entry represents ribosomal protein aS21, an archaea-specific component of the small ribosomal subunit (SSU). The protein was first characterised as HVO_2753 (Small CPxCG-related zinc finger protein) from Haloferax volcanii [ ] and has been identified in ribosome structures from Pyrococcus abyssi [ ] and Pyrobaculu... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF07754"
] | [
"HVO_2753_ZBP"
] | [
779
] | 1 | [] | [] | [] | 0 | [
"6skf",
"6skg",
"6sw9",
"6swc",
"6swd",
"6th6",
"6tmf",
"6ydh",
"7zag",
"7zah",
"7zai",
"7zhg",
"9e71",
"9e7f",
"9fhl",
"9fny",
"9fnz",
"9fo0",
"9fra",
"9frk",
"9frl",
"9fs6",
"9fs8",
"9fsf",
"9fy0",
"9o17",
"9qf4",
"9qf5",
"9qf6"
] | 29 | [
"PUB00096940",
"PUB00114374",
"PUB00161688",
"PUB00161770"
] | [
"32905660",
"32029867",
"32555463",
"40676158"
] | [
"Biological functions, genetic and biochemical characterization, and NMR structure determination of the small zinc finger protein HVO_2753 from Haloferax volcanii.",
"Cryo-EM study of an archaeal 30S initiation complex gives insights into evolution of translation initiation.",
"Dynamic RNA acetylation revealed ... | [
2020,
2020,
2020,
2025
] | 4 | [] | [] | 0 | 0 | null | [
"Archaea",
"ecological metagenomes"
] | [
772,
7
] | 2 | [] | [] | 0 | true | Domain | Ribosomal protein aS21, zinc-binding pocket | Ribosomal protein aS21, zinc-binding pocket | Ribosomal_aS21_ZBP | 5 |
IPR011669 | 11,669 | D-glutamate N-acetyltransferase-like | DgcN-like | Family | 3,624 | false | false | This entry represents a group of prokaryotic proteins that includes from Tritonibacter scottomollicae (DgcN), an N-acetyltransferase responsible for N-acetylation of D-Glutamate, an essential component of bacterial peptidoglycans. DgcN consists of an N-terminal Rossman-like domain , with four β-strands composing a hydr... | [] | [] | [] | 0 | [
"PIRSF",
"PANTHER"
] | [
"PIRSF026760",
"PTHR40690"
] | [
"UCP026760",
""
] | [
3435,
3624
] | 2 | [] | [] | [] | 0 | [
"2g0t",
"2obn",
"7xrj"
] | 3 | [
"PUB00103733"
] | [
"36690779"
] | [
"Novel D-glutamate catabolic pathway in marine Proteobacteria and halophilic archaea."
] | [
2023
] | 1 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Caudoviricetes",
"Opisthokonta",
"metagenomes"
] | [
510,
3016,
10,
3,
85
] | 5 | [] | [] | 0 | true | Family | D-glutamate N-acetyltransferase-like | D-glutamate N-acetyltransferase-like | DgcN-like | 9 |
IPR011670 | 11,670 | Domain of unknown function DUF1612 | DUF1612 | Domain | 1,063 | false | false | This entry represents a domain of unknown function found in a group of proteins mainly from alphaproteobacteria. Many members of this group are known to associate symbiotically with plants. Moreover, the majority are coded for by plasmids, which in many cases are known to confer on the organism the ability to interact ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF07756"
] | [
"DUF1612"
] | [
1063
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00004254",
"PUB00015202"
] | [
"9163424",
"12271122"
] | [
"Molecular basis of symbiosis between Rhizobium and legumes.",
"The Brucella suis genome reveals fundamental similarities between animal and plant pathogens and symbionts."
] | [
1997,
2002
] | 2 | [] | [] | 0 | 0 | null | [
"Alphaproteobacteria",
"Eukaryota"
] | [
1060,
3
] | 2 | [] | [] | 0 | true | Domain | Domain of unknown function DUF1612 | Domain of unknown function DUF1612 | DUF1612 | 2 |
IPR011672 | 11,672 | Protein of unknown function DUF1614 | DUF1614 | Family | 917 | false | false | This is a family of sequences coming from hypothetical proteins found in both bacterial and archaeal species. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF07758"
] | [
"DUF1614"
] | [
917
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
341,
545,
2,
29
] | 4 | [] | [] | 0 | true | Family | Protein of unknown function DUF1614 | Protein of unknown function DUF1614 | DUF1614 | 6 |
IPR011673 | 11,673 | Protein of unknown function DUF1615 | DUF1615 | Family | 2,954 | false | false | This is a family of proteins of unknown function expressed by various bacterial species. Some members of this family (e.g. , ) are thought to be lipoproteins. Another member of this family ( ) is thought to be involved in photosynthesis [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF07759"
] | [
"DUF1615"
] | [
2954
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00015226"
] | [
"10976061"
] | [
"Molecular evidence for the early evolution of photosynthesis."
] | [
2000
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Beauveria bassiana D1-5",
"metagenomes"
] | [
2949,
1,
4
] | 3 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Protein of unknown function DUF1615 | Protein of unknown function DUF1615 | DUF1615 | 1 |
IPR011674 | 11,674 | Domain of unknown function DUF1616 | DUF1616 | Domain | 1,418 | false | false | This is a group of sequences from hypothetical archaeal and bacterial proteins. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF07760"
] | [
"DUF1616"
] | [
1418
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"ecological metagenomes"
] | [
1286,
77,
55
] | 3 | [] | [] | 0 | true | Domain | Domain of unknown function DUF1616 | Domain of unknown function DUF1616 | DUF1616 | 7 |
IPR011676 | 11,676 | Domain of unknown function DUF1618 | DUF1618 | Domain | 6,096 | false | false | The proteins of this entry are mainly hypothetical proteins expressed by Oryza sativa. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF07762"
] | [
"DUF1618"
] | [
6096
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Mesangiospermae"
] | [
6096
] | 1 | [
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
348,
79
] | 2 | true | Domain | Domain of unknown function DUF1618 | Domain of unknown function DUF1618 | DUF1618 | 2 |
IPR011677 | 11,677 | Tectonic-1-3 domain | TCTN1-3_dom | Domain | 3,804 | false | false | This is a conserved domain found in tectonic proteins (TCTN1/2/3) which contains a Cys rich N-terminal region. Although its function is currently unknown (this domain is also found as DUF1619), studies in TCTN2 suggest that it is indispensable for normal functions [ , ]. These proteins form a complex required for hedge... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF07773"
] | [
"TCTN_DUF1619"
] | [
3804
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-5620912",
"R-MMU-5620912",
"R-RNO-5620912"
] | [
"REACTOME:R-HSA-5620912",
"REACTOME:R-MMU-5620912",
"REACTOME:R-RNO-5620912"
] | 3 | [] | 0 | [
"PUB00069722",
"PUB00097826",
"PUB00097827",
"PUB00160606"
] | [
"22179047",
"29866362",
"27770015",
"37704658"
] | [
"A ciliopathy complex at the transition zone protects the cilia as a privileged membrane domain.",
"Super-Resolution Imaging Reveals TCTN2 Depletion-Induced IFT88 Lumen Leakage and Ciliary Weakening.",
"Open Sesame: How Transition Fibers and the Transition Zone Control Ciliary Composition.",
"The tectonic com... | [
2012,
2018,
2017,
2023
] | 4 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
3804
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
6,
1,
23,
6,
11
] | 5 | true | Domain | Tectonic-1-3 domain | Tectonic-1-3 domain | TCTN1-3_dom | 8 |
IPR011678 | 11,678 | ER membrane protein complex subunit 1, C-terminal | EMC1_C | Domain | 5,541 | false | false | This entry represents the second β-propeller domain found at the C-terminal of ER membrane protein complex subunit 1. ER membrane protein complex subunit 1 (EMC1) is a component of the endoplasmic reticulum membrane protein complex (EMC, composed of EMC1, EMC2, EMC3, EMC4, EMC5 and EMC6) that enables the energy-indepen... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF07774"
] | [
"EMC1_C"
] | [
5541
] | 1 | [] | [] | [] | 0 | [
"6wb9",
"6ww7",
"7ado",
"7adp",
"7kra",
"7ktx",
"8eoi",
"8j0n",
"8j0o",
"8s9s",
"9c7v"
] | 11 | [
"PUB00061987",
"PUB00096678",
"PUB00096681",
"PUB00096682"
] | [
"19325107",
"30415835",
"32459176",
"32439656"
] | [
"Comprehensive characterization of genes required for protein folding in the endoplasmic reticulum.",
"EMC Is Required to Initiate Accurate Membrane Protein Topogenesis.",
"The architecture of EMC reveals a path for membrane protein insertion.",
"Structural basis for membrane insertion by the human ER membran... | [
2009,
2018,
2020,
2020
] | 4 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
5541
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
5,
1,
3,
4,
7,
2,
1,
4,
4,
1,
1,
25
] | 12 | true | Domain | ER membrane protein complex subunit 1, C-terminal | ER membrane protein complex subunit 1, C-terminal | EMC1_C | 9 |
IPR011679 | 11,679 | Endoplasmic reticulum resident protein 29, C-terminal | ERp29_C | Domain | 4,214 | false | false | ERp29 (also known as ERp28 and ERp31) is a ubiquitously expressed endoplasmic reticulum protein found in mammals [ ]. This protein has an N-terminal thioredoxin-like domain, which is homologous to the domain of human protein disulphide isomerase (PDI). ERp29 may help mediate the chaperone function of PDI. The C-termina... | [
"GO:0005783"
] | [
"endoplasmic reticulum"
] | [
"cellular_component"
] | 1 | [
"PFAM",
"CDD"
] | [
"PF07749",
"cd00238"
] | [
"ERp29",
"ERp29c"
] | [
4211,
3510
] | 2 | [] | [] | [] | 0 | [
"1g7d",
"1ovn",
"2c0e",
"2c0f",
"2c0g",
"2c1y",
"2m66",
"2qc7",
"5v8z",
"5v90",
"6o6i"
] | 11 | [
"PUB00014099",
"PUB00015222",
"PUB00029610"
] | [
"11435111",
"11884402",
"12941941"
] | [
"Thioredoxin fold as homodimerization module in the putative chaperone ERp29: NMR structures of the domains and experimental model of the 51 kDa dimer.",
"Identification of ERp29, an endoplasmic reticulum lumenal protein, as a new member of the thyroglobulin folding complex.",
"Crystal structure and functional ... | [
2001,
2002,
2003
] | 3 | [] | [] | 0 | 0 | null | [
"Clostridium tetani",
"Eukaryota"
] | [
2,
4212
] | 2 | [
"Arabidopsis thaliana",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)",
"Zea mays"
] | [
6,
2,
3,
1,
1,
3,
3,
1,
41
] | 9 | true | Domain | Endoplasmic reticulum resident protein 29, C-terminal | Endoplasmic reticulum resident protein 29, C-terminal | ERp29_C | 5 |
IPR011680 | 11,680 | Fasciculation and elongation protein zeta, FEZ | FEZ | Family | 3,798 | false | false | The first member of the FEZ (fasciculation and elongation protein zeta) family identified was unc-76, from C. elegans. The protein is necessary for normal axon fasciculation and is required for axon-axon interactions [ ]. Later, two human homologues, FEZ1 and FEZ2, were identified [ ]. FEZ1 and FEZ2 interact with PKCze... | [] | [] | [] | 0 | [
"PFAM",
"PANTHER"
] | [
"PF07763",
"PTHR12394"
] | [
"FEZ",
""
] | [
3700,
3760
] | 2 | [] | [] | [] | 0 | [] | 0 | [
"PUB00015197",
"PUB00015198",
"PUB00066959"
] | [
"14697253",
"9096408",
"8401577"
] | [
"Identification of a tissue-non-specific homologue of axonal fasciculation and elongation protein zeta-1.",
"The Caenorhabditis elegans gene unc-76 and its human homologs define a new gene family involved in axonal outgrowth and fasciculation.",
"dbEST--database for \"expressed sequence tags\"."
] | [
2004,
1997,
1993
] | 3 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
3798
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
9,
6,
3,
17,
15,
16
] | 6 | true | Family | Fasciculation and elongation protein zeta, FEZ | Fasciculation and elongation protein zeta, FEZ | FEZ | 5 |
IPR011681 | 11,681 | GcrA cell cycle regulator | GcrA | Family | 3,766 | false | false | GcrA, together with CtrA (see and ), form a master cell cycle regulator. These bacterial regulators are involved in controlling the progression and asymmetric polar morphogenesis [ ]. During this process, there are temporal and spatial variations in the concentrations of GcrA and CtrA. The variation in concentration pr... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF07750"
] | [
"GcrA"
] | [
3766
] | 1 | [] | [] | [] | 0 | [
"5yiu",
"5yiv",
"5yiw",
"5yix",
"5z7i",
"7ye1",
"7ye2"
] | 7 | [
"PUB00015220"
] | [
"15087506"
] | [
"Oscillating global regulators control the genetic circuit driving a bacterial cell cycle."
] | [
2004
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Opisthokonta",
"Viruses",
"unclassified sequences"
] | [
3637,
3,
75,
51
] | 4 | [] | [] | 0 | true | Family | GcrA cell cycle regulator | GcrA cell cycle regulator | GcrA | 3 |
IPR011682 | 11,682 | Glycosyl hydrolase family 38, C-terminal | Glyco_hydro_38_C | Domain | 26,160 | false | false | Glycoside hydrolase family 38 comprises enzymes with only one known activity; alpha-mannosidase ( ) ( ). This domain is found at the C terminus of glycosyl hydrolases from family 38. O-Glycosyl hydrolases ( ) are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or betw... | [
"GO:0004559",
"GO:0006013"
] | [
"alpha-mannosidase activity",
"mannose metabolic process"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PFAM"
] | [
"PF07748"
] | [
"Glyco_hydro_38C"
] | [
26160
] | 1 | [
"EC",
"GP",
"GP",
"GP",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"3.2.1.24",
"GenProp1299",
"GenProp1444",
"GenProp1524",
"R-BTA-6798695",
"R-BTA-8853383",
"R-DDI-6798695",
"R-DDI-8853383",
"R-DME-975578",
"R-HSA-6798695",
"R-HSA-6811438",
"R-HSA-8853383",
"R-HSA-9694548",
"R-HSA-975578",
"R-MMU-6798695",
"R-MMU-8853383",
"R-MMU-975578",
"R-RNO-... | [
"EC:3.2.1.24",
"GP:GenProp1299",
"GP:GenProp1444",
"GP:GenProp1524",
"REACTOME:R-BTA-6798695",
"REACTOME:R-BTA-8853383",
"REACTOME:R-DDI-6798695",
"REACTOME:R-DDI-8853383",
"REACTOME:R-DME-975578",
"REACTOME:R-HSA-6798695",
"REACTOME:R-HSA-6811438",
"REACTOME:R-HSA-8853383",
"REACTOME:R-HSA-... | 21 | [
"1hty",
"1hww",
"1hxk",
"1o7d",
"1ps3",
"1qwn",
"1qwu",
"1qx1",
"1r33",
"1r34",
"1tqs",
"1tqt",
"1tqu",
"1tqv",
"1tqw",
"2alw",
"2f18",
"2f1a",
"2f1b",
"2f7o",
"2f7p",
"2f7q",
"2f7r",
"2fyv",
"2ow6",
"2ow7",
"2wyh",
"2wyi",
"3blb",
"3bub",
"3bud",
"3bui"... | 84 | [
"PUB00004870",
"PUB00005266"
] | [
"7624375",
"8535779"
] | [
"Conserved catalytic machinery and the prediction of a common fold for several families of glycosyl hydrolases.",
"Structures and mechanisms of glycosyl hydrolases."
] | [
1995,
1995
] | 2 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Siphoviridae sp. ctBLh2",
"unclassified sequences"
] | [
114,
9933,
15997,
1,
115
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
29,
4,
20,
17,
1,
26,
19,
1,
15,
25,
1,
1,
44
] | 13 | true | Domain | Glycosyl hydrolase family 38, C-terminal | Glycosyl hydrolase family 38, C-terminal | Glyco_hydro_38_C | 7 |
IPR011683 | 11,683 | Glycosyl hydrolase family 53 | Glyco_hydro_53 | Family | 6,133 | false | false | O-Glycosyl hydrolases ( ) are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycosyl hydrolases, based on sequence similarity, has led to the definition of 85 different families [ ,... | [
"GO:0015926"
] | [
"glucosidase activity"
] | [
"molecular_function"
] | 1 | [
"PFAM",
"PANTHER"
] | [
"PF07745",
"PTHR34983"
] | [
"Glyco_hydro_53",
""
] | [
6130,
5973
] | 2 | [
"EC"
] | [
"3.2.1.89"
] | [
"EC:3.2.1.89"
] | 1 | [
"1fhl",
"1fob",
"1hjq",
"1hjs",
"1hju",
"1r8l",
"1ur0",
"1ur4",
"2ccr",
"2gft",
"2j74",
"4bf7",
"6gp5",
"6gpa",
"6q3r",
"7osk",
"9fli"
] | 17 | [
"PUB00004870",
"PUB00005266",
"PUB00015221",
"PUB00096634"
] | [
"7624375",
"8535779",
"12484750",
"27501980"
] | [
"Conserved catalytic machinery and the prediction of a common fold for several families of glycosyl hydrolases.",
"Structures and mechanisms of glycosyl hydrolases.",
"Aspergillus aculeatus beta-1,4-galactanase: substrate recognition and relations to other glycoside hydrolases in clan GH-A.",
"Role of the gan... | [
1995,
1995,
2002,
2016
] | 4 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
7,
4530,
1561,
35
] | 4 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)"
] | [
1
] | 1 | true | Family | Glycosyl hydrolase family 53 | Glycosyl hydrolase family 53 | Glyco_hydro_53 | 3 |
IPR011684 | 11,684 | Protein Networked (NET), actin-binding (NAB) domain | NAB | Domain | 7,620 | false | false | This entry represents the NAB domain found in the Networked proteins. The Networked (NET) proteins are a superfamily of plant-specific actin-binding proteins which localise simultaneously to the actin cytoskeleton and specific membrane compartments and are suggested to couple these membranes to the actin cytoskeleton i... | [
"GO:0003779"
] | [
"actin binding"
] | [
"molecular_function"
] | 1 | [
"PFAM",
"PROFILE"
] | [
"PF07765",
"PS51774"
] | [
"KIP1",
"NAB"
] | [
7086,
7570
] | 2 | [] | [] | [] | 0 | [] | 0 | [
"PUB00062155",
"PUB00077736"
] | [
"22840520",
"24926301"
] | [
"A superfamily of actin-binding proteins at the actin-membrane nexus of higher plants.",
"The evolution of the actin binding NET superfamily."
] | [
2012,
2014
] | 2 | [] | [] | 0 | 0 | null | [
"Streptophyta"
] | [
7620
] | 1 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
80,
39,
109
] | 3 | true | Domain | Protein Networked (NET), actin-binding (NAB) domain | Protein Networked (NET), actin-binding (NAB) domain | NAB | 5 |
IPR011686 | 11,686 | Omega transcriptional repressor | Omega_repress | Domain | 261 | false | false | The omega transcriptional repressor regulates expression of genes involved in copy number control and stable maintenance of plasmids. The omega protein belongs to the structural superfamily of MetJ/Arc repressors featuring a ribbon-helix-helix DNA-binding motif with the β-ribbon located in and recognising the major gro... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF07764"
] | [
"Omega_Repress"
] | [
261
] | 1 | [] | [] | [] | 0 | [
"1irq",
"2bnw",
"2bnz",
"2cax"
] | 4 | [
"PUB00014024"
] | [
"11733997"
] | [
"Crystal structure of omega transcriptional repressor encoded by Streptococcus pyogenes plasmid pSM19035 at 1.5 A resolution."
] | [
2001
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"plasmids"
] | [
258,
3
] | 2 | [] | [] | 0 | true | Domain | Omega transcriptional repressor | Omega transcriptional repressor | Omega_repress | 5 |
IPR011687 | 11,687 | Ribosome biogenesis protein Nop53/GLTSCR2 | Nop53/GLTSCR2 | Family | 4,417 | false | false | This entry includes glioma tumour suppressor candidate region gene 2 protein (GSCR2) from humans and ribosome biogenesis protein Nop53 from budding yeasts. GSCR2 bears similarity to the glioma tumour suppressor candidate region gene 2 protein (p60) [ ]. Nop53 is a nucleolar protein that is involved in biogenesis of the... | [] | [] | [] | 0 | [
"PFAM",
"PIRSF",
"PANTHER"
] | [
"PF07767",
"PIRSF017302",
"PTHR14211"
] | [
"Nop53",
"Gltscr2",
""
] | [
4394,
3647,
4292
] | 3 | [] | [] | [] | 0 | [
"3jct",
"5ooq",
"6m62",
"6ylx",
"6yly",
"7btb",
"7ohq",
"7u0h",
"7uoo",
"7uqb",
"7uqz",
"7v08",
"8fkz",
"8fl2",
"8fl3",
"8fl4",
"8fl6",
"8fl7",
"8fla",
"8flb",
"8fld",
"8fle",
"8ine",
"8inf",
"8ipx",
"8ipy",
"8ir3",
"8pv1",
"8pv3",
"8pv4",
"8pv6",
"8pv7"... | 34 | [
"PUB00014564",
"PUB00019936",
"PUB00073499"
] | [
"10708517",
"15686447",
"16128814"
] | [
"A transcript map of the chromosome 19q-arm glioma tumor suppressor region.",
"Nop53p is a novel nucleolar 60S ribosomal subunit biogenesis protein.",
"Nop53p, an essential nucleolar protein that interacts with Nop17p and Nip7p, is required for pre-rRNA processing in Saccharomyces cerevisiae."
] | [
2000,
2005,
2005
] | 3 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"bird metagenome"
] | [
4416,
1
] | 2 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
9,
1,
2,
1,
14,
5,
1,
4,
6,
1,
1,
10
] | 12 | true | Family | Ribosome biogenesis protein Nop53/GLTSCR2 | Ribosome biogenesis protein Nop53/GLTSCR2 | Nop53/GLTSCR2 | 4 |
IPR011688 | 11,688 | PVL Orf50 family | PVL_Orf50 | Family | 284 | false | false | This is a family of sequences, found in both bacteria and bacteriophages, whose function is not currently known. It includes Orf50 from the Staphylococcus phage PVL [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF07768"
] | [
"PVL_ORF50"
] | [
284
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00056597"
] | [
"9666077"
] | [
"Complete nucleotide sequence and molecular characterization of the temperate staphylococcal bacteriophage phiPVL carrying Panton-Valentine leukocidin genes."
] | [
1998
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Viruses",
"human gut metagenome"
] | [
150,
133,
1
] | 3 | [] | [] | 0 | true | Family | PVL Orf50 family | PVL Orf50 family | PVL_Orf50 | 9 |
IPR011689 | 11,689 | PaRep2b | PaRep2b | Domain | 168 | false | false | This is a group of proteins, expressed in the crenarchaeon Pyrobaculum aerophilum, whose members are variable in length and level of conservation. The presence of numerous frameshifts and internal stop codons in multiple alignments are thought to indicate that most family members are no longer functional [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF07775"
] | [
"PaRep2b"
] | [
168
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00015213"
] | [
"11792869"
] | [
"Genome sequence of the hyperthermophilic crenarchaeon Pyrobaculum aerophilum."
] | [
2002
] | 1 | [] | [] | 0 | 0 | null | [
"Archaea",
"Flagellimonas profundi"
] | [
167,
1
] | 2 | [] | [] | 0 | true | Domain | PaRep2b | PaRep2b | PaRep2b | 9 |
IPR011690 | 11,690 | Phosphate-starvation-induced PsiF repeat | P_starv_induced_PsiF | Repeat | 2,901 | false | false | This region is approximately 35 residues long. It is found repeated in a number of putative phosphate starvation-inducible proteins expressed by various bacterial species. PsiF ( ) is known to be an example of such phosphate starvation-inducible proteins [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF07769"
] | [
"PsiF_repeat"
] | [
2901
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00015199"
] | [
"2160940"
] | [
"Identification of phosphate starvation-inducible genes in Escherichia coli K-12 by DNA sequence analysis of psi::lacZ(Mu d1) transcriptional fusions."
] | [
1990
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Opisthokonta",
"metagenomes"
] | [
2885,
5,
11
] | 3 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Repeat | Phosphate-starvation-induced PsiF repeat | Phosphate-starvation-induced PsiF repeat | P_starv_induced_PsiF | 4 |
IPR011691 | 11,691 | Vesicle transport protein SFT2 | Vesicle_transpt_SFT2 | Family | 9,082 | false | false | Sft2 is a non-essential membrane protein that localizes to a late-Golgi compartment and is involved in vesicle fusion with the Golgi complex [ , ]. It is thought to interact with Sed5, a yeast t-SNARE protein that plays a role in ER-Golgi and intra-Golgi vesicular transport [ , ]. Sft2 and related proteins are found in... | [
"GO:0016192",
"GO:0016020"
] | [
"vesicle-mediated transport",
"membrane"
] | [
"biological_process",
"cellular_component"
] | 2 | [
"PANTHER"
] | [
"PTHR23137"
] | [
""
] | [
9082
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00009891",
"PUB00015208",
"PUB00087251",
"PUB00087253"
] | [
"10406798",
"7596416",
"9725919",
"28927260"
] | [
"Got1p and Sft2p: membrane proteins involved in traffic to the Golgi complex.",
"A SNARE-like protein required for traffic through the Golgi complex.",
"The dynamics of golgi protein traffic visualized in living yeast cells.",
"The Roles of the SNARE Protein Sed5 in Autophagy in Saccharomyces cerevisiae."
] | [
1999,
1995,
1998,
2017
] | 4 | [
"IPR007305"
] | [] | 1 | 0 | 1 | [
"Eukaryota",
"Klosneuvirinae",
"marine metagenome"
] | [
9076,
4,
2
] | 3 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
15,
5,
4,
6,
4,
5,
1,
10,
13,
1,
1,
23
] | 12 | true | Family | Vesicle transport protein SFT2 | Vesicle transport protein SFT2 | Vesicle_transpt_SFT2 | 3 |
IPR011692 | 11,692 | Stress up-regulated Nod 19 | Stress_up-reg_Nod19 | Family | 2,246 | false | false | This family of plant proteins have been implicated in nodule development [ ] in the legume Medicago truncatula (Barrel medic). MtN-19 was shown by Northern blot to be induced during nodulation [ ]. The molecular function of these proteins is unknown. | [] | [] | [] | 0 | [
"PFAM",
"PANTHER"
] | [
"PF07712",
"PTHR33390"
] | [
"SURNod19",
""
] | [
2242,
2078
] | 2 | [] | [] | [] | 0 | [] | 0 | [
"PUB00007493"
] | [
"8634476"
] | [
"Use of a subtractive hybridization approach to identify new Medicago truncatula genes induced during root nodule development."
] | [
1996
] | 1 | [] | [] | 0 | 0 | null | [
"Actinomycetota",
"Eukaryota",
"freshwater metagenome"
] | [
29,
2214,
3
] | 3 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
7,
2,
6
] | 3 | true | Family | Stress up-regulated Nod 19 | Stress up-regulated Nod 19 | Stress_up-reg_Nod19 | 3 |
IPR011694 | 11,694 | Ixonnexin-like | Ixonnexin-like | Family | 551 | false | false | This entry represents a group of proteins from arachnides, including Ixonnexin from the deer tick Ixodes scapularis [ ] and other peptides derived from a salivary gland cDNA library of this organism [ ]. Also present are peptides from a related tick species, Ixodes ricinus (Sheep tick). Members of this family are chara... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF07771"
] | [
"TSGP1"
] | [
551
] | 1 | [] | [] | [] | 0 | [
"7ne8"
] | 1 | [
"PUB00015212",
"PUB00154965"
] | [
"12177149",
"29555911"
] | [
"Exploring the sialome of the tick Ixodes scapularis.",
"Ixonnexin from Tick Saliva Promotes Fibrinolysis by Interacting with Plasminogen and Tissue-Type Plasminogen Activator, and Prevents Arterial Thrombosis."
] | [
2002,
2018
] | 2 | [] | [] | 0 | 0 | null | [
"Opisthokonta"
] | [
551
] | 1 | [] | [] | 0 | true | Family | Ixonnexin-like | Ixonnexin-like | Ixonnexin-like | 2 |
IPR011695 | 11,695 | Tash protein, PEST motif | Tash_PEST_motif | Conserved_site | 129 | false | false | The PEST motif is found in one or more copies in Tash AT-hook proteins from Theileria annulata. Tash proteins are transported to the host nucleus and are thought to be involved in pathogenesis [ ]. The PEST motif is often found in conjunction with the ( ), whose function is unknown. These repeats may be part of the PES... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF07708"
] | [
"Tash_PEST"
] | [
129
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00015193",
"PUB00015194"
] | [
"15075278",
"11683409"
] | [
"A Theileria annulata DNA binding protein localized to the host cell nucleus alters the phenotype of a bovine macrophage cell line.",
"Characterisation of a cluster of genes encoding Theileria annulata AT hook DNA-binding proteins and evidence for localisation to the host cell nucleus."
] | [
2004,
2001
] | 2 | [] | [] | 0 | 0 | null | [
"Theileria"
] | [
129
] | 1 | [] | [] | 0 | true | Conserved_site | Tash protein, PEST motif | Tash protein, PEST motif | Tash_PEST_motif | 2 |
IPR011696 | 11,696 | Huwentoxin-1 family | Huwentoxin-1 | Family | 254 | false | false | This entry describes huwentoxins, the endoparasitoid wasp peptide Teratocyte protein CftICK-IV, which has immununosuppressive and insecticidal activities [ ] and related proteins. Huwentoxins function as ion-channel inhibitors. Omega-Grammotoxin SIA is a VSCC antagonist that inhibits neuronal N- and P-type VSCC respons... | [
"GO:0008200",
"GO:0005576"
] | [
"ion channel inhibitor activity",
"extracellular region"
] | [
"molecular_function",
"cellular_component"
] | 2 | [
"PFAM"
] | [
"PF07740"
] | [
"Toxin_12"
] | [
254
] | 1 | [] | [] | [] | 0 | [
"1d1h",
"1emx",
"1koz",
"1la4",
"1s6x",
"2a2v",
"2mxm",
"2n1n",
"3j5q",
"5t4r",
"6v6t",
"8cjq",
"8cjs",
"8cjt",
"8fey",
"9ep7"
] | 16 | [
"PUB00017227",
"PUB00028940",
"PUB00057515",
"PUB00057516",
"PUB00096648",
"PUB00097926",
"PUB00152807"
] | [
"12827284",
"12228241",
"8394998",
"20189991",
"32826759",
"30784059",
"36434808"
] | [
"Isolation and characterization of hainantoxin-IV, a novel antagonist of tetrodotoxin-sensitive sodium channels from the Chinese bird spider Selenocosmia hainana.",
"Function and solution structure of huwentoxin-IV, a potent neuronal tetrodotoxin (TTX)-sensitive sodium channel antagonist from Chinese bird spider ... | [
2003,
2002,
1993,
2010,
2020,
2019,
2023
] | 7 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"marine sediment metagenome"
] | [
3,
250,
1
] | 3 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)"
] | [
1
] | 1 | true | Family | Huwentoxin-1 family | Huwentoxin-1 family | Huwentoxin-1 | 8 |
IPR011697 | 11,697 | Peptidase C26 | Peptidase_C26 | Family | 23,115 | false | false | These peptidases have gamma-glutamyl hydrolase activity; that is they catalyse the cleavage of the gamma-glutamyl bond in poly-gamma-glutamyl substrates. They are structurally related to , but contain extensions in four loops and at the C terminus [ ]. They belong to MEROPS peptidase family C26 (gamma-glutamyl hydrolas... | [
"GO:0016787"
] | [
"hydrolase activity"
] | [
"molecular_function"
] | 1 | [
"PFAM"
] | [
"PF07722"
] | [
"Peptidase_C26"
] | [
23115
] | 1 | [
"GP",
"GP",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"GenProp1279",
"GenProp1434",
"R-BTA-6798695",
"R-DDI-6798695",
"R-HSA-6798695",
"R-MMU-6798695",
"R-RNO-6798695"
] | [
"GP:GenProp1279",
"GP:GenProp1434",
"REACTOME:R-BTA-6798695",
"REACTOME:R-DDI-6798695",
"REACTOME:R-HSA-6798695",
"REACTOME:R-MMU-6798695",
"REACTOME:R-RNO-6798695"
] | 7 | [
"1l9x",
"3fij",
"4l7q",
"4l8f",
"4l8w",
"4l8y",
"4l95",
"6vtv",
"7d4r",
"7d50",
"7d53"
] | 11 | [
"PUB00011704",
"PUB00015219",
"PUB00020025",
"PUB00030423",
"PUB00076953"
] | [
"11517925",
"11953431",
"9891971",
"14725770",
"7044372"
] | [
"Evolutionary lines of cysteine peptidases.",
"Three-dimensional structure of human gamma -glutamyl hydrolase. A class I glatamine amidotransferase adapted for a complex substate.",
"Identification of the active site of legumain links it to caspases, clostripain and gingipains in a new clan of cysteine endopept... | [
2001,
2002,
1998,
2004,
1982
] | 5 | [] | [
"IPR015527",
"IPR044668"
] | 0 | 2 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
72,
18013,
4666,
14,
350
] | 5 | [
"Arabidopsis thaliana",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)",
"Zea mays"
] | [
30,
5,
3,
2,
6,
3,
5,
2,
1,
15
] | 10 | true | Family | Peptidase C26 | Peptidase C26 | Peptidase_C26 | 9 |
IPR011698 | 11,698 | CobB/CobQ-like glutamine amidotransferase | GATase_3 | Domain | 35,117 | false | false | This group of enzymes was suggested to be related to the MinD family of ATPases involved in regulation of cell division in bacteria and archaea [ ]. Further sequence analysis suggests a model for the interaction of CobB and CobQ with their respective substrates [ ]. CobB and CobQ were also found to contain unusual Tria... | [
"GO:0003824"
] | [
"catalytic activity"
] | [
"molecular_function"
] | 1 | [
"PFAM"
] | [
"PF07685"
] | [
"GATase_3"
] | [
35117
] | 1 | [] | [] | [] | 0 | [
"5n9m",
"6fqb",
"6gs2",
"6h5e",
"7q8e",
"9sq9",
"9sqj"
] | 7 | [
"PUB00015238"
] | [
"10966576"
] | [
"The synthetase domains of cobalamin biosynthesis amidotransferases cobB and cobQ belong to a new family of ATP-dependent amidoligases, related to dethiobiotin synthetase."
] | [
2000
] | 1 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
1690,
32867,
176,
384
] | 4 | [] | [] | 0 | true | Domain | CobB/CobQ-like glutamine amidotransferase | CobB/CobQ-like glutamine amidotransferase | GATase_3 | 4 |
IPR011699 | 11,699 | Mycoplasma MFS transporter | MFS_Mycoplasma | Family | 128 | false | false | These proteins share some similarity with members of the Major Facilitator Superfamily (MFS). | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF07672"
] | [
"MFS_Mycoplasma"
] | [
128
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Vespula germanica"
] | [
127,
1
] | 2 | [] | [] | 0 | true | Family | Mycoplasma MFS transporter | Mycoplasma MFS transporter | MFS_Mycoplasma | 2 |
IPR011703 | 11,703 | ATPase, AAA-3 | ATPase_AAA-3 | Domain | 43,383 | false | false | This entry includes some of the AAA proteins not detected by the model. AAA ATPases form a large, functionally diverse protein family belonging to the AAA+ superfamily of ring-shaped P-loop NTPases, which exert their activity through the energy-dependent unfolding of macromolecules. AAA ATPases contain a P-loop NTPase ... | [
"GO:0005524",
"GO:0016887"
] | [
"ATP binding",
"ATP hydrolysis activity"
] | [
"molecular_function",
"molecular_function"
] | 2 | [
"PFAM"
] | [
"PF07726"
] | [
"AAA_3"
] | [
43383
] | 1 | [] | [] | [] | 0 | [
"2r44"
] | 1 | [
"PUB00014778",
"PUB00014779"
] | [
"15037234",
"15037233"
] | [
"Evolutionary history and higher order classification of AAA+ ATPases.",
"Phylogenetic analysis of AAA proteins."
] | [
2004,
2004
] | 2 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Caudoviricetes",
"Eukaryota",
"unclassified sequences"
] | [
1773,
40863,
3,
102,
642
] | 5 | [] | [] | 0 | true | Domain | ATPase, AAA-3 | ATPase, AAA-3 | ATPase_AAA-3 | 4 |
IPR011704 | 11,704 | ATPase, dynein-related, AAA domain | ATPase_dyneun-rel_AAA | Domain | 54,663 | false | false | The ATPases Associated to a variety of cellular Activities (AAA) are a family distinguished by a highly conserved module of 230 amino acids [ ]. The highly conserved nature of this module across taxa suggests that it has a key cellular role. Members of the family are involved in diverse cellular functions including gen... | [
"GO:0005524",
"GO:0016887"
] | [
"ATP binding",
"ATP hydrolysis activity"
] | [
"molecular_function",
"molecular_function"
] | 2 | [
"PFAM"
] | [
"PF07728"
] | [
"AAA_5"
] | [
54663
] | 1 | [] | [] | [] | 0 | [
"5c3c",
"5jcs",
"6hyp",
"6hz4",
"6hz5",
"6hz6",
"6hz7",
"6hz8",
"6hz9",
"6i26",
"6i27",
"6l1q",
"6or5",
"6or6",
"6orb",
"6ut3",
"6ut4",
"6ut5",
"6ut6",
"6ut7",
"6ut8",
"6ylf",
"6ylh",
"7vsr"
] | 24 | [
"PUB00000729",
"PUB00005841"
] | [
"7646486",
"9927482"
] | [
"A 200-amino acid ATPase module in search of a basic function.",
"AAA+: A class of chaperone-like ATPases associated with the assembly, operation, and disassembly of protein complexes."
] | [
1995,
1999
] | 2 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
1134,
41442,
10821,
480,
786
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
8,
3,
3,
10,
2,
4,
6,
1,
2,
7,
1,
1,
7
] | 13 | true | Domain | ATPase, dynein-related, AAA domain | ATPase, dynein-related, AAA domain | ATPase_dyneun-rel_AAA | 3 |
IPR011705 | 11,705 | BTB/Kelch-associated | BACK | Domain | 93,146 | false | false | This domain is found associated with BTB/POZ domain ( ) and Kelch repeats ( ). BTB (broad-complex, tramtrack and bric a brac) is a Kelch related domain, also known as the POZ domain [ ]. BTB proteins are divided into subgroups depending on what domain lies at the C terminus. Despite the divergence in sequences, the BTB... | [] | [] | [] | 0 | [
"PFAM",
"SMART"
] | [
"PF07707",
"SM00875"
] | [
"BACK",
"BACK"
] | [
92415,
82990
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-114608",
"R-BTA-8951664",
"R-BTA-983168",
"R-DDI-114608",
"R-DDI-8951664",
"R-DDI-983168",
"R-DME-8951664",
"R-DME-983168",
"R-DRE-114608",
"R-DRE-4641258",
"R-DRE-5689880",
"R-DRE-8951664",
"R-DRE-9755511",
"R-DRE-983168",
"R-GGA-8951664",
"R-GGA-983168",
"R-HSA-114608",
"R... | [
"REACTOME:R-BTA-114608",
"REACTOME:R-BTA-8951664",
"REACTOME:R-BTA-983168",
"REACTOME:R-DDI-114608",
"REACTOME:R-DDI-8951664",
"REACTOME:R-DDI-983168",
"REACTOME:R-DME-8951664",
"REACTOME:R-DME-983168",
"REACTOME:R-DRE-114608",
"REACTOME:R-DRE-4641258",
"REACTOME:R-DRE-5689880",
"REACTOME:R-DR... | 43 | [
"2eqx",
"3hve",
"3i3n",
"4ap2",
"4apf",
"4hxi",
"6i2m",
"6wcq",
"8gq6",
"8h33",
"8h34",
"8h35",
"8h36",
"8h37",
"8h38",
"8h3a",
"8h3f",
"8h3r",
"8k8t",
"8khp",
"8voj",
"8vpq",
"8vrt",
"8w4j",
"9dtg",
"9dtq",
"9ggl",
"9ggm",
"9ggn",
"9i2c",
"9ijj"
] | 31 | [
"PUB00019197",
"PUB00033636",
"PUB00043340"
] | [
"15544948",
"16207353",
"16582008"
] | [
"The BACK domain in BTB-kelch proteins.",
"Sequence and structural analysis of BTB domain proteins.",
"The aryl hydrocarbon receptor signaling pathway is modified through interactions with a Kelch protein."
] | [
2004,
2005,
2006
] | 3 | [] | [
"IPR030568",
"IPR030575",
"IPR030579",
"IPR030582",
"IPR030609",
"IPR042950",
"IPR047027",
"IPR047028",
"IPR047030",
"IPR047060",
"IPR047062",
"IPR047067",
"IPR047068",
"IPR047069",
"IPR047071",
"IPR047074",
"IPR047097",
"IPR047098",
"IPR047931",
"IPR047936",
"IPR049737"
] | 0 | 21 | 0 | [
"Eukaryota",
"Nucleocytoviricota",
"metagenomes"
] | [
92555,
589,
2
] | 3 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
25,
22,
183,
61,
173,
140,
8,
190,
31
] | 9 | true | Domain | BTB/Kelch-associated | BTB/Kelch-associated | BACK | 4 |
IPR011706 | 11,706 | Multicopper oxidase, C-terminal | Cu-oxidase_C | Domain | 86,951 | false | false | This entry represents the C-terminal domain of multicopper oxidase and related proteins some of which have lost the ability to bind copper. Copper is one of the most prevalent transition metals in living organisms and its biological function is intimately related to its redox properties. Since free copper is toxic, eve... | [
"GO:0005507",
"GO:0016491"
] | [
"copper ion binding",
"oxidoreductase activity"
] | [
"molecular_function",
"molecular_function"
] | 2 | [
"PFAM"
] | [
"PF07731"
] | [
"Cu-oxidase_2"
] | [
86951
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-HSA-114608",
"R-HSA-140837",
"R-HSA-140875",
"R-HSA-163841",
"R-HSA-204005",
"R-HSA-381426",
"R-HSA-425410",
"R-HSA-5619049",
"R-HSA-5619060",
"R-HSA-5655799",
"R-HSA-5694530",
"R-HSA-8957275",
"R-HSA-917937",
"R-HSA-9672383",
"R-HSA-9672387",
"R-HSA-9672391",
"R-HSA-9672393",
"... | [
"REACTOME:R-HSA-114608",
"REACTOME:R-HSA-140837",
"REACTOME:R-HSA-140875",
"REACTOME:R-HSA-163841",
"REACTOME:R-HSA-204005",
"REACTOME:R-HSA-381426",
"REACTOME:R-HSA-425410",
"REACTOME:R-HSA-5619049",
"REACTOME:R-HSA-5619060",
"REACTOME:R-HSA-5655799",
"REACTOME:R-HSA-5694530",
"REACTOME:R-HSA... | 36 | [
"1a65",
"1aoz",
"1aso",
"1asp",
"1asq",
"1gsk",
"1gw0",
"1gyc",
"1hfu",
"1kcw",
"1kv7",
"1kya",
"1n68",
"1of0",
"1pf3",
"1v10",
"1w6l",
"1w6w",
"1w8e",
"1zpu",
"2bhf",
"2fqd",
"2fqe",
"2fqf",
"2fqg",
"2h5u",
"2hrg",
"2hrh",
"2hzh",
"2ih8",
"2ih9",
"2j5w"... | 364 | [
"PUB00000062",
"PUB00000901",
"PUB00001382",
"PUB00001602",
"PUB00011817",
"PUB00035911",
"PUB00035912",
"PUB00035913",
"PUB00101322",
"PUB00101323",
"PUB00101324"
] | [
"3052293",
"8293473",
"2404764",
"1995346",
"11867755",
"14572631",
"11041837",
"16234932",
"35079912",
"9413439",
"35175277"
] | [
"Cofactor proteins in the assembly and expression of blood clotting enzyme complexes.",
"The FET3 gene of S. cerevisiae encodes a multicopper oxidase required for ferrous iron uptake.",
"The blue oxidases, ascorbate oxidase, laccase and ceruloplasmin. Modelling and structural relationships.",
"A structure-der... | [
1988,
1994,
1990,
1991,
2002,
2003,
2000,
2005,
2022,
1997,
2022
] | 11 | [] | [
"IPR034267",
"IPR034275",
"IPR034279",
"IPR034289",
"IPR035666"
] | 0 | 5 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"Mimiviridae",
"unclassified sequences"
] | [
681,
29907,
56074,
5,
284
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
191,
2,
6,
16,
2,
19,
12,
11,
105,
16,
3,
1,
180
] | 13 | true | Domain | Multicopper oxidase, C-terminal | Multicopper oxidase, C-terminal | Cu-oxidase_C | 9 |
IPR011707 | 11,707 | Multicopper oxidase-like, N-terminal | Cu-oxidase-like_N | Domain | 92,015 | false | false | This entry represents the N-terminal domain (or coupled binuclear) of multicopper oxidase. Copper is one of the most prevalent transition metals in living organisms and its biological function is intimately related to its redox properties. Since free copper is toxic, even at very low concentrations, its homeostasis in ... | [
"GO:0005507"
] | [
"copper ion binding"
] | [
"molecular_function"
] | 1 | [
"PFAM"
] | [
"PF07732"
] | [
"Cu-oxidase_3"
] | [
92015
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-HSA-114608",
"R-HSA-140837",
"R-HSA-140875",
"R-HSA-163841",
"R-HSA-204005",
"R-HSA-381426",
"R-HSA-425410",
"R-HSA-5619049",
"R-HSA-5619060",
"R-HSA-5655799",
"R-HSA-5694530",
"R-HSA-8957275",
"R-HSA-917937",
"R-HSA-9672383",
"R-HSA-9672387",
"R-HSA-9672391",
"R-HSA-9672393",
"... | [
"REACTOME:R-HSA-114608",
"REACTOME:R-HSA-140837",
"REACTOME:R-HSA-140875",
"REACTOME:R-HSA-163841",
"REACTOME:R-HSA-204005",
"REACTOME:R-HSA-381426",
"REACTOME:R-HSA-425410",
"REACTOME:R-HSA-5619049",
"REACTOME:R-HSA-5619060",
"REACTOME:R-HSA-5655799",
"REACTOME:R-HSA-5694530",
"REACTOME:R-HSA... | 36 | [
"1a65",
"1aoz",
"1aq8",
"1as6",
"1as7",
"1as8",
"1aso",
"1asp",
"1asq",
"1bq5",
"1et5",
"1et7",
"1et8",
"1gs6",
"1gs7",
"1gs8",
"1gsk",
"1gw0",
"1gyc",
"1hau",
"1haw",
"1hfu",
"1j9q",
"1j9r",
"1j9s",
"1j9t",
"1kbv",
"1kbw",
"1kcb",
"1kcw",
"1kv7",
"1kya"... | 622 | [
"PUB00000062",
"PUB00000901",
"PUB00001382",
"PUB00001602",
"PUB00011817",
"PUB00035911",
"PUB00035912",
"PUB00035913",
"PUB00101322",
"PUB00101323",
"PUB00101324"
] | [
"3052293",
"8293473",
"2404764",
"1995346",
"11867755",
"14572631",
"11041837",
"16234932",
"35079912",
"9413439",
"35175277"
] | [
"Cofactor proteins in the assembly and expression of blood clotting enzyme complexes.",
"The FET3 gene of S. cerevisiae encodes a multicopper oxidase required for ferrous iron uptake.",
"The blue oxidases, ascorbate oxidase, laccase and ceruloplasmin. Modelling and structural relationships.",
"A structure-der... | [
1988,
1994,
1990,
1991,
2002,
2003,
2000,
2005,
2022,
1997,
2022
] | 11 | [] | [
"IPR034259",
"IPR034273",
"IPR034284",
"IPR034288",
"IPR048236"
] | 0 | 5 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified Klosneuvirinae",
"unclassified sequences"
] | [
1266,
32279,
58140,
4,
326
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
168,
1,
5,
14,
2,
30,
19,
11,
105,
19,
3,
1,
162
] | 13 | true | Domain | Multicopper oxidase-like, N-terminal | Multicopper oxidase-like, N-terminal | Cu-oxidase-like_N | 5 |
IPR011708 | 11,708 | Bacterial DNA polymerase III, alpha subunit, NTPase domain | DNA_pol3_alpha_NTPase_dom | Domain | 49,636 | false | false | This is a conserved region found in the the DNA polymerase III alpha subunit, ( ). DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The alpha chain is the DNA polymerase [ ]. | [
"GO:0008408",
"GO:0006260"
] | [
"3'-5' exonuclease activity",
"DNA replication"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PFAM"
] | [
"PF07733"
] | [
"DNA_pol3_alpha"
] | [
49636
] | 1 | [
"EC"
] | [
"2.7.7.7"
] | [
"EC:2.7.7.7"
] | 1 | [
"2hnh",
"2hpi",
"2hpm",
"2hqa",
"3e0d",
"3f2b",
"3f2c",
"3f2d",
"4iqj",
"4jom",
"5fku",
"5fkv",
"5fkw",
"5lew",
"5m1s",
"7pu7",
"9qpc",
"9qrl",
"9qrn"
] | 19 | [
"PUB00019430"
] | [
"9685491"
] | [
"Phosphoesterase domains associated with DNA polymerases of diverse origins."
] | [
1998
] | 1 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
5,
47862,
183,
543,
1043
] | 5 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Domain | Bacterial DNA polymerase III, alpha subunit, NTPase domain | Bacterial DNA polymerase III, alpha subunit, NTPase domain | DNA_pol3_alpha_NTPase_dom | 3 |
IPR011709 | 11,709 | DEAD-box helicase, OB fold | DEAD-box_helicase_OB_fold | Domain | 66,649 | false | false | This domain is found towards the C terminus of the DEAD-box helicases ( ). In these helicases it is apparently always found in association with . There do seem to be a couple of instances where it occurs by itself - e.g. . This C-terminal domain of the yeast helicase contains an oligonucleotide/oligosaccharide-binding ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF07717"
] | [
"OB_NTP_bind"
] | [
66649
] | 1 | [
"EC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
... | [
"3.6.4.13",
"R-BTA-159236",
"R-BTA-1810476",
"R-BTA-3134963",
"R-BTA-72163",
"R-BTA-72187",
"R-BTA-73856",
"R-BTA-9833482",
"R-CEL-159236",
"R-CEL-3134963",
"R-CEL-6791226",
"R-CEL-72163",
"R-CEL-72187",
"R-CEL-73856",
"R-CEL-9833482",
"R-DDI-72163",
"R-DME-1810476",
"R-DME-3134963... | [
"EC:3.6.4.13",
"REACTOME:R-BTA-159236",
"REACTOME:R-BTA-1810476",
"REACTOME:R-BTA-3134963",
"REACTOME:R-BTA-72163",
"REACTOME:R-BTA-72187",
"REACTOME:R-BTA-73856",
"REACTOME:R-BTA-9833482",
"REACTOME:R-CEL-159236",
"REACTOME:R-CEL-3134963",
"REACTOME:R-CEL-6791226",
"REACTOME:R-CEL-72163",
"... | 41 | [
"2xau",
"3i4u",
"3kx2",
"5aor",
"5d0u",
"5gm6",
"5i8q",
"5jpt",
"5lj5",
"5lqw",
"5lta",
"5ltj",
"5ltk",
"5mq0",
"5mqf",
"5n8r",
"5n8s",
"5n8u",
"5n8z",
"5n90",
"5n94",
"5n96",
"5n98",
"5n9a",
"5n9d",
"5n9e",
"5n9f",
"5vha",
"5vhc",
"5vhd",
"5vhe",
"5wsg"... | 156 | [
"PUB00064170",
"PUB00092307"
] | [
"23096351",
"20512115"
] | [
"Structural analysis of the C-terminal domain of the spliceosomal helicase Prp22.",
"Prp43p contains a processive helicase structural architecture with a specific regulatory domain."
] | [
2012,
2010
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
12185,
54377,
87
] | 3 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
106,
13,
47,
44,
1,
56,
43,
9,
49,
57,
7,
9,
134
] | 13 | true | Domain | DEAD-box helicase, OB fold | DEAD-box helicase, OB fold | DEAD-box_helicase_OB_fold | 2 |
IPR011710 | 11,710 | Coatomer beta subunit, C-terminal | Coatomer_bsu_C | Domain | 5,184 | false | false | This entry represents the C-terminal domain of the beta subunit from coatomer proteins (Beta-coat proteins). The C-terminal domain probably adapts the function of the N-terminal domain. Coatomer protein complex I (COPI)-coated vesicles are involved in transport between the endoplasmic reticulum and the Golgi but also p... | [
"GO:0005198",
"GO:0006886",
"GO:0016192",
"GO:0030126"
] | [
"structural molecule activity",
"intracellular protein transport",
"vesicle-mediated transport",
"COPI vesicle coat"
] | [
"molecular_function",
"biological_process",
"biological_process",
"cellular_component"
] | 4 | [
"PFAM"
] | [
"PF07718"
] | [
"Coatamer_beta_C"
] | [
5184
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-6798695",
"R-BTA-6807878",
"R-BTA-6811434",
"R-DDI-6798695",
"R-DDI-6807878",
"R-DDI-6811434",
"R-DME-6798695",
"R-DME-6807878",
"R-DME-6811434",
"R-DRE-6798695",
"R-DRE-6807878",
"R-DRE-6811434",
"R-GGA-6798695",
"R-GGA-6807878",
"R-GGA-6811434",
"R-HSA-6798695",
"R-HSA-68078... | [
"REACTOME:R-BTA-6798695",
"REACTOME:R-BTA-6807878",
"REACTOME:R-BTA-6811434",
"REACTOME:R-DDI-6798695",
"REACTOME:R-DDI-6807878",
"REACTOME:R-DDI-6811434",
"REACTOME:R-DME-6798695",
"REACTOME:R-DME-6807878",
"REACTOME:R-DME-6811434",
"REACTOME:R-DRE-6798695",
"REACTOME:R-DRE-6807878",
"REACTOM... | 30 | [
"5a1u",
"5a1v",
"5a1w",
"5a1x",
"5a1y",
"5nzr",
"5nzs",
"5nzt",
"5nzu",
"5nzv",
"9qpq"
] | 11 | [
"PUB00030524",
"PUB00033346",
"PUB00035767",
"PUB00035768",
"PUB00035769",
"PUB00100149",
"PUB00103198"
] | [
"14690497",
"12893528",
"11208122",
"17041781",
"15261670",
"26160949",
"28621666"
] | [
"Gamma-COP appendage domain - structure and function.",
"ER-to-Golgi transport: COP I and COP II function (Review).",
"Traffic COPs of the early secretory pathway.",
"COPI-mediated transport.",
"COP and clathrin-coated vesicle budding: different pathways, common approaches.",
"VESICULAR TRANSPORT. A struc... | [
2004,
2003,
2000,
2006,
2004,
2015,
2017
] | 7 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
5184
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
6,
1,
1,
1,
1,
1,
1,
5,
3,
1,
1,
22
] | 12 | true | Domain | Coatomer beta subunit, C-terminal | Coatomer beta subunit, C-terminal | Coatomer_bsu_C | 7 |
IPR011711 | 11,711 | GntR, C-terminal | GntR_C | Domain | 188,279 | false | false | Many bacterial transcription regulation proteins bind DNA through a helix-turn-helix (HTH) motif, which can be classified into subfamilies on the basis of sequence similarities. The HTH GntR family has many members distributed among diverse bacterial groups that regulate various biological processes. It was named GntR ... | [] | [] | [] | 0 | [
"PFAM",
"SMART"
] | [
"PF07729",
"SM00895"
] | [
"FCD",
"FCD"
] | [
188177,
180594
] | 2 | [] | [] | [] | 0 | [
"2di3",
"2hs5",
"3c7j",
"3fms",
"3ihu",
"3sxk",
"3sxm",
"3sxy",
"3sxz",
"4p9f",
"5tpm",
"6az6",
"6ep3",
"6on4",
"6wfq",
"6wg7",
"6z74",
"6za0",
"6za3",
"6za7",
"6zab",
"7c7e",
"7u5q",
"7xp0",
"7xp1",
"9isw",
"9jpj",
"9jpk",
"9jpl",
"9vkn"
] | 30 | [
"PUB00001726",
"PUB00015265"
] | [
"2060763",
"11756427"
] | [
"A new family of bacterial regulatory proteins.",
"Subdivision of the helix-turn-helix GntR family of bacterial regulators in the FadR, HutC, MocR, and YtrA subfamilies."
] | [
1991,
2002
] | 2 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Sym plasmid",
"unclassified sequences"
] | [
51,
186826,
121,
1,
1280
] | 5 | [
"Arabidopsis thaliana",
"Escherichia coli (strain K12)"
] | [
1,
12
] | 2 | true | Domain | GntR, C-terminal | GntR, C-terminal | GntR_C | 4 |
IPR011712 | 11,712 | Signal transduction histidine kinase, subgroup 3, dimerisation and phosphoacceptor domain | Sig_transdc_His_kin_sub3_dim/P | Domain | 143,997 | false | false | This entry represents the dimerisation and phosphoacceptor domain of a sub-family of histidine kinases. It shares sequence similarity with and . Two-component signal transduction systems enable bacteria to sense, respond, and adapt to a wide range of environments, stressors, and growth conditions [ ]. Some bacteria can... | [
"GO:0000155",
"GO:0046983",
"GO:0000160",
"GO:0016020"
] | [
"phosphorelay sensor kinase activity",
"protein dimerization activity",
"phosphorelay signal transduction system",
"membrane"
] | [
"molecular_function",
"molecular_function",
"biological_process",
"cellular_component"
] | 4 | [
"PFAM"
] | [
"PF07730"
] | [
"HisKA_3"
] | [
143997
] | 1 | [
"EC"
] | [
"2.7.13.3"
] | [
"EC:2.7.13.3"
] | 1 | [
"3ehf",
"3ehh",
"3ehj",
"3gie",
"3gif",
"3gig",
"5iuj",
"5iuk",
"5iul",
"5ium",
"7ssi",
"7ssj"
] | 12 | [
"PUB00000966",
"PUB00007866",
"PUB00010651",
"PUB00011096",
"PUB00013246",
"PUB00013247",
"PUB00013562",
"PUB00013563",
"PUB00020801",
"PUB00042804",
"PUB00042805",
"PUB00042806",
"PUB00042807"
] | [
"9989504",
"11406410",
"12372152",
"10966457",
"8868347",
"10426948",
"8029829",
"1482126",
"11145881",
"16176121",
"18076326",
"11934609",
"11489844"
] | [
"Structure of CheA, a signal-transducing histidine kinase.",
"Histidine kinases and response regulator proteins in two-component signaling systems.",
"Histidine protein kinases: key signal transducers outside the animal kingdom.",
"Two-component signal transduction.",
"Protein aspartate phosphatases control... | [
1999,
2001,
2002,
2000,
1996,
1999,
1994,
1992,
2000,
2005,
2007,
2002,
2001
] | 13 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Siphoviridae sp. ctBLh2",
"unclassified sequences"
] | [
143159,
50,
1,
787
] | 4 | [
"Escherichia coli (strain K12)"
] | [
3
] | 1 | true | Domain | Signal transduction histidine kinase, subgroup 3, dimerisation and phosphoacceptor domain | Signal transduction histidine kinase, subgroup 3, dimerisation and phosphoacceptor domain | Sig_transdc_His_kin_sub3_dim/P | 1 |
IPR011713 | 11,713 | Leucine-rich repeat 3 | Leu-rich_rpt_3 | Repeat | 7,780 | false | false | Leucine-rich repeats (LRR) consist of 2-45 motifs of 20-30 amino acids in length that generally folds into an arc or horseshoe shape [ ]. LRRs occur in proteins ranging from viruses to eukaryotes, and appear to provide a structural framework for the formation of protein-protein interactions [ , ].Proteins containing LR... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF07725"
] | [
"LRR_3"
] | [
7780
] | 1 | [
"EC",
"METACYC"
] | [
"3.2.2.6",
"PWY-5381"
] | [
"EC:3.2.2.6",
"METACYC:PWY-5381"
] | 2 | [
"7crb",
"7crc",
"7dfv"
] | 3 | [
"PUB00001625",
"PUB00001898",
"PUB00007147",
"PUB00007148",
"PUB00017058",
"PUB00094376"
] | [
"1657640",
"2176636",
"11751054",
"11967365",
"14747988",
"21606681"
] | [
"A leucine-rich repeat peptide derived from the Drosophila Toll receptor forms extended filaments with a beta-sheet structure.",
"slit: an extracellular protein necessary for development of midline glia and commissural axon pathways contains both EGF and LRR domains.",
"The leucine-rich repeat as a protein reco... | [
1991,
1990,
2001,
2002,
2004,
2011
] | 6 | [] | [] | 0 | 0 | null | [
"Mesangiospermae"
] | [
7780
] | 1 | [
"Arabidopsis thaliana"
] | [
836
] | 1 | true | Repeat | Leucine-rich repeat 3 | Leucine-rich repeat 3 | Leu-rich_rpt_3 | 2 |
IPR011714 | 11,714 | Seven residue repeat | Seve_residue_repeat | Repeat | 34 | false | false | This repeat is found in some Plasmodium and Theileria proteins. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF07709"
] | [
"SRR"
] | [
34
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacillati",
"Eukaryota",
"viral metagenome"
] | [
3,
30,
1
] | 3 | [] | [] | 0 | true | Repeat | Seven residue repeat | Seven residue repeat | Seve_residue_repeat | 4 |
IPR011715 | 11,715 | Tyrosine aminotransferase ubiquitination region | Tyr_aminoTrfase_ubiquitination | Conserved_site | 673 | false | false | This region contains a probable site of ubiquitination that ensures rapid degradation of tyrosine aminotransferase in rats. The half life of the enzyme in vivo is about 2-4 hours. The enzyme contains at least 2 phosphorylation sites including CAPK at Ser29 and, at the other end of the protein, a casein kinase II site a... | [
"GO:0004838",
"GO:0030170",
"GO:0009074"
] | [
"L-tyrosine-2-oxoglutarate transaminase activity",
"pyridoxal phosphate binding",
"aromatic amino acid family catabolic process"
] | [
"molecular_function",
"molecular_function",
"biological_process"
] | 3 | [
"PFAM"
] | [
"PF07706"
] | [
"TAT_ubiq"
] | [
673
] | 1 | [
"EC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"2.6.1.5",
"R-BTA-8963684",
"R-HSA-8963684",
"R-MMU-8963684",
"R-RNO-8963684"
] | [
"EC:2.6.1.5",
"REACTOME:R-BTA-8963684",
"REACTOME:R-HSA-8963684",
"REACTOME:R-MMU-8963684",
"REACTOME:R-RNO-8963684"
] | 5 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Euteleostomi"
] | [
673
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
4,
3,
5
] | 3 | true | Conserved_site | Tyrosine aminotransferase ubiquitination region | Tyrosine aminotransferase ubiquitination region | Tyr_aminoTrfase_ubiquitination | 3 |
IPR011716 | 11,716 | Tetratricopeptide TPR-3 | TPR-3 | Repeat | 1,570 | false | false | This entry includes tetratricopeptide-like repeats found in the LcrH/SycD-like chaperones [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF07720"
] | [
"TPR_3"
] | [
1570
] | 1 | [] | [] | [] | 0 | [
"2vgx",
"2vgy",
"3gyz",
"3gz1",
"3gz2",
"3ks2",
"4am9",
"4nrh",
"6scb",
"7axy",
"7ayw",
"7azv",
"7b1u",
"7nhw",
"7nl8",
"7nrg",
"7o04",
"7o6s",
"7owv",
"7p42",
"7pe0",
"7pef",
"8j9c",
"8j9d",
"8qh6"
] | 25 | [
"PUB00015206"
] | [
"12799000"
] | [
"Tetratricopeptide-like repeats in type-III-secretion chaperones and regulators."
] | [
2003
] | 1 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
11,
1387,
163,
9
] | 4 | [
"Escherichia coli (strain K12)",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Zea mays"
] | [
1,
1,
1
] | 3 | true | Repeat | Tetratricopeptide TPR-3 | Tetratricopeptide TPR-3 | TPR-3 | 2 |
IPR011717 | 11,717 | Tetratricopeptide TPR-4 | TPR-4 | Repeat | 4,924 | false | false | This entry includes tetratricopeptide-like repeats not detected by the , and models. The tetratricopeptide repeat (TPR) motif is a protein-protein interaction module found in multiple copies in a number of functionally different proteins that facilitates specific interactions with a partner protein(s) [ ]. | [
"GO:0042802"
] | [
"identical protein binding"
] | [
"molecular_function"
] | 1 | [
"PFAM"
] | [
"PF07721"
] | [
"TPR_4"
] | [
4924
] | 1 | [] | [] | [] | 0 | [
"8fwd",
"9k7u"
] | 2 | [
"PUB00015447"
] | [
"10517866"
] | [
"The tetratricopeptide repeat: a structural motif mediating protein-protein interactions."
] | [
1999
] | 1 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"ecological metagenomes"
] | [
24,
4090,
757,
53
] | 4 | [
"Zea mays"
] | [
3
] | 1 | true | Repeat | Tetratricopeptide TPR-4 | Tetratricopeptide TPR-4 | TPR-4 | 7 |
IPR011718 | 11,718 | Glutamate--cysteine ligase GshA | GshA | Family | 1,625 | false | false | This entry represents a rare family of glutamate--cysteine ligases, demonstrated first in Thiobacillus ferrooxidans and present in a few other Proteobacteria [ ]. It is the first of two enzymes for glutathione biosynthesis. It is also called gamma-glutamylcysteine synthetase. | [] | [] | [] | 0 | [
"PFAM",
"NCBIFAM"
] | [
"PF08886",
"TIGR02049"
] | [
"GshA",
"gshA_ferroox"
] | [
1625,
1579
] | 2 | [
"GP"
] | [
"GenProp0030"
] | [
"GP:GenProp0030"
] | 1 | [
"3k1t"
] | 1 | [
"PUB00015299"
] | [
"8828222"
] | [
"The gene for gamma-glutamylcysteine synthetase from Thiobacillus ferrooxidans has low homology to its Escherichia coli equivalent and is linked to the gene for citrate synthase."
] | [
1996
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"environmental samples",
"unclassified sequences"
] | [
1574,
13,
3,
35
] | 4 | [] | [] | 0 | true | Family | Glutamate--cysteine ligase GshA | Glutamate--cysteine ligase GshA | GshA | 3 |
IPR011719 | 11,719 | Conserved hypothetical protein CHP02058 | CHP02058 | Family | 2,106 | false | false | This family consists of few members, broadly distributed. It occurs so far in several Firmicutes (twice in Oceanobacillus), one Cyanobacterium, one alpha Proteobacterium, and (with a long prefix) in plants. The function is unknown. The alignment includes a perfectly conserved motif GxGxDxHG near the N terminus. | [] | [] | [] | 0 | [
"PFAM",
"PANTHER",
"NCBIFAM"
] | [
"PF09585",
"PTHR34784",
"TIGR02058"
] | [
"Lin0512_fam",
"",
"lin0512_fam"
] | [
2100,
2049,
1853
] | 3 | [] | [] | [] | 0 | [
"3c8l"
] | 1 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"ecological metagenomes"
] | [
9,
1337,
727,
33
] | 4 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
10,
4,
3
] | 3 | true | Family | Conserved hypothetical protein CHP02058 | Conserved hypothetical protein CHP02058 | CHP02058 | 9 |
IPR011720 | 11,720 | Thr operon leader peptide | Thr_lead_pept | Family | 643 | false | false | This family consists of examples of the threonine biosynthesis (Thr) operon leader peptide, also called the Thr operon attenuator. The small gene for this peptide is often missed in genome annotation. It should be looked for in genomes of the proteobacteria, immediately upstream of genes for threonine biosynthesis, typ... | [
"GO:0009088",
"GO:0031554",
"GO:0031556"
] | [
"L-threonine biosynthetic process",
"regulation of termination of DNA-templated transcription",
"transcriptional attenuation by ribosome"
] | [
"biological_process",
"biological_process",
"biological_process"
] | 3 | [
"HAMAP",
"PFAM",
"NCBIFAM"
] | [
"MF_01907",
"PF08254",
"TIGR02077"
] | [
"Leader_Thr",
"Leader_Thr",
"thr_lead_pep"
] | [
540,
578,
624
] | 3 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"human gut metagenome"
] | [
642,
1
] | 2 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Thr operon leader peptide | Thr operon leader peptide | Thr_lead_pept | 3 |
IPR011721 | 11,721 | Conserved hypothetical protein CHP02096 | CHP02096 | Family | 1,712 | false | false | This entry represents proteins, which are about 135 amino acids in length and largely restricted to the Proteobacteria. This family and a delta5-3-ketosteroid isomerase from Pseudomonas testosteroni appear homologous, especially toward their respective N-termini. Members, therefore, probably are enzymes [ , ]. | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"TIGR02096"
] | [
""
] | [
1712
] | 1 | [] | [] | [] | 0 | [
"3f7x",
"3f8h",
"3i0y"
] | 3 | [
"PUB00032196",
"PUB00151023"
] | [
"15819891",
"29750129"
] | [
"Small exterior hydrophobic cluster contributes to conformational stability and steroid binding in ketosteroid isomerase from Pseudomonas putida biotype B.",
"Engineering the \"Missing Link\" in Biosynthetic (-)-Menthol Production: Bacterial Isopulegone Isomerase."
] | [
2005,
2018
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"ecological metagenomes"
] | [
1709,
3
] | 2 | [] | [] | 0 | true | Family | Conserved hypothetical protein CHP02096 | Conserved hypothetical protein CHP02096 | CHP02096 | 1 |
IPR011722 | 11,722 | Hemimethylated DNA-binding domain | Hemimethylated_DNA-bd_dom | Domain | 10,117 | false | false | Heat shock protein HspQ, also known as YccV, is an Escherichia coli hemimethylated DNA binding protein which has been shown to regulate dnaA gene expression [ , ]. This entry represents a YccV-like hemimethylated DNA binding domain that can also be found in longer eukaryotic proteins, such as F-box only protein 21 from... | [
"GO:0003677"
] | [
"DNA binding"
] | [
"molecular_function"
] | 1 | [
"PFAM",
"SMART",
"NCBIFAM"
] | [
"PF08755",
"SM00992",
"TIGR02097"
] | [
"YccV-like",
"YccV-like",
"yccV"
] | [
9736,
9858,
7298
] | 3 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-8951664",
"R-HSA-983168",
"R-MMU-8951664",
"R-MMU-983168"
] | [
"REACTOME:R-HSA-8951664",
"REACTOME:R-HSA-983168",
"REACTOME:R-MMU-8951664",
"REACTOME:R-MMU-983168"
] | 4 | [
"5ycq",
"6z9c",
"6zlx"
] | 3 | [
"PUB00015300",
"PUB00104944"
] | [
"12700277",
"28575662"
] | [
"Isolation of a new hemimethylated DNA binding protein which regulates dnaA gene expression.",
"HspQ Functions as a Unique Specificity-Enhancing Factor for the AAA+ Lon Protease."
] | [
2003,
2017
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
3634,
6409,
74
] | 3 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
9,
2,
3,
2,
1,
8,
4,
1,
5,
4,
1
] | 11 | true | Domain | Hemimethylated DNA-binding domain | Hemimethylated DNA-binding domain | Hemimethylated_DNA-bd_dom | 5 |
IPR011723 | 11,723 | Zinc finger/thioredoxin putative | Znf/thioredoxin_put | Domain | 6,598 | false | false | This entry represents a region, which contains a CXXCX(19)CXXC motif, is usually found at the N terminus of prokaryotic proteins. One partially characterised gene, agmX, is among a large set in Myxococcus whose interruption affects adventurous gliding motility [ ]. This domain is predicted to adopt a fold typical for z... | [] | [] | [] | 0 | [
"PFAM",
"PFAM",
"NCBIFAM"
] | [
"PF13717",
"PF13719",
"TIGR02098"
] | [
"Zn_ribbon_4",
"Zn_ribbon_5",
"MJ0042_CXXC"
] | [
3412,
2351,
6381
] | 3 | [] | [] | [] | 0 | [
"2nb9",
"7zok"
] | 2 | [
"PUB00014077",
"PUB00015301",
"PUB00035804",
"PUB00035805",
"PUB00035806",
"PUB00035807",
"PUB00035812"
] | [
"12665246",
"12828649",
"17210253",
"15963892",
"15718139",
"10529348",
"11179890"
] | [
"Zinc fingers--folds for many occasions.",
"Identification of genes required for adventurous gliding motility in Myxococcus xanthus with the transposable element mariner.",
"Sticky fingers: zinc-fingers as protein-recognition motifs.",
"Multiple modes of RNA recognition by zinc finger proteins.",
"Zinc fing... | [
2002,
2003,
2007,
2005,
2005,
1999,
2001
] | 7 | [] | [] | 0 | 0 | null | [
"Alphaspiravirus yamagawaense",
"Archaea",
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
1,
17,
6387,
81,
112
] | 5 | [] | [] | 0 | true | Domain | Zinc finger/thioredoxin putative | Zinc finger/thioredoxin putative | Znf/thioredoxin_put | 3 |
IPR011724 | 11,724 | Cyd operon protein YbgT | Cyd_oper_YbgT | Family | 3,992 | false | false | This entry describes a very small (as short as 33 amino acids) protein of unknown function, essentially always found in an operon with CydAB, subunits of the cytochrome d terminal oxidase [ ]. It begins with an aromatic motif MWYFXW and appears to contain a membrane-spanning helix. This protein appears to be restricted... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"TIGR02106"
] | [
"cyd_oper_ybgT"
] | [
3992
] | 1 | [
"GP",
"GP",
"GP",
"GP",
"GP",
"GP"
] | [
"GenProp0617",
"GenProp1141",
"GenProp1269",
"GenProp1373",
"GenProp1515",
"GenProp1608"
] | [
"GP:GenProp0617",
"GP:GenProp1141",
"GP:GenProp1269",
"GP:GenProp1373",
"GP:GenProp1515",
"GP:GenProp1608"
] | 6 | [
"6rko",
"6rx4"
] | 2 | [
"PUB00015302"
] | [
"9068659"
] | [
"Characterization of the tol-pal and cyd region of Escherichia coli K-12: transcript analysis and identification of two new proteins encoded by the cyd operon."
] | [
1997
] | 1 | [
"IPR012994"
] | [] | 1 | 0 | 1 | [
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
3972,
2,
18
] | 3 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Cyd operon protein YbgT | Cyd operon protein YbgT | Cyd_oper_YbgT | 3 |
IPR011725 | 11,725 | Coenzyme PQQ biosynthesis protein A | PQQ_synth_PqqA | Family | 2,791 | false | false | This entry describes a very small protein, coenzyme PQQ biosynthesis protein A, which is smaller than 25 amino acids in many species. It is proposed to serve as a peptide precursor of coenzyme pyrrolo-quinoline-quinone (PQQ), with Glu and Tyr of a conserved motif Glu-Xxx-Xxx-Xxx-Tyr becoming part of the product [ ]. | [
"GO:0018189"
] | [
"pyrroloquinoline quinone biosynthetic process"
] | [
"biological_process"
] | 1 | [
"HAMAP",
"PFAM",
"NCBIFAM"
] | [
"MF_00656",
"PF08042",
"TIGR02107"
] | [
"PQQ_syn_PqqA",
"PqqA",
"PQQ_syn_pqqA"
] | [
1829,
2619,
2769
] | 3 | [
"GP"
] | [
"GenProp0170"
] | [
"GP:GenProp0170"
] | 1 | [] | 0 | [
"PUB00015303"
] | [
"9467911"
] | [
"pqqA is not required for biosynthesis of pyrroloquinoline quinone in Methylobacterium extorquens AM1."
] | [
1998
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Laccaria fraterna",
"ecological metagenomes",
"uncultured Caudovirales phage"
] | [
2784,
1,
5,
1
] | 4 | [] | [] | 0 | true | Family | Coenzyme PQQ biosynthesis protein A | Coenzyme PQQ biosynthesis protein A | PQQ_synth_PqqA | 8 |
IPR011726 | 11,726 | K+ transporting P-type ATPase, F subunit | KdpF | Family | 6,877 | false | false | This entry represents the F subunit (KdpF) of a P-type K+ translocating ATPase (Kdp) in archaea and bacteria. KdpF is a very small integral membrane peptide. The kdpABC operon of Escherichia coli codes for the high affinity K+ translocating Kdp complex [ , ]. KdpF is found upstream of the KdpA subunit ( ). Because of i... | [
"GO:0008556",
"GO:0043462",
"GO:0005886"
] | [
"P-type potassium transmembrane transporter activity",
"regulation of ATP-dependent activity",
"plasma membrane"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PFAM",
"NCBIFAM"
] | [
"PF09604",
"TIGR02115"
] | [
"Potass_KdpF",
"potass_kdpF"
] | [
6851,
5300
] | 2 | [
"GP"
] | [
"GenProp0172"
] | [
"GP:GenProp0172"
] | 1 | [
"5mrw",
"6hra",
"6hrb",
"7bgy",
"7bh1",
"7bh2",
"7lc3",
"7lc6",
"7nnl",
"7nnp",
"7zrd",
"7zre",
"7zrg",
"7zrh",
"7zri",
"7zrj",
"7zrk",
"7zrl",
"7zrm",
"9oc4"
] | 20 | [
"PUB00009724",
"PUB00020603",
"PUB00020604",
"PUB00060972",
"PUB00068786",
"PUB00068787",
"PUB00068788",
"PUB00068789"
] | [
"10608856",
"15473999",
"15078220",
"9789555",
"20450191",
"18937357",
"1385979",
"9741106"
] | [
"The KdpF subunit is part of the K(+)-translocating Kdp complex of Escherichia coli and is responsible for stabilization of the complex in vitro.",
"The evolution of A-, F-, and V-type ATP synthases and ATPases: reversals in function and changes in the H+/ATP coupling ratio.",
"Mechanisms of ATPases--a multi-di... | [
1999,
2004,
2004,
1998,
2010,
2008,
1992,
1998
] | 8 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Methanobacteriati",
"metagenomes"
] | [
6851,
6,
20
] | 3 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | K+ transporting P-type ATPase, F subunit | K+ transporting P-type ATPase, F subunit | KdpF | 7 |
IPR011727 | 11,727 | Conserved hypothetical protein CHP02117 | CHP02117 | Family | 2,788 | false | false | This conserved hypothetical protein of unknown function is predominantly found in proteobacteria. Its function is unknown and its genome context is not well-conserved. It is found amid urease genes in at least one species. | [] | [] | [] | 0 | [
"PFAM",
"NCBIFAM"
] | [
"PF09601",
"TIGR02117"
] | [
"DUF2459",
"chp_urease_rgn"
] | [
2788,
2034
] | 2 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Rhabditida",
"unclassified sequences"
] | [
2759,
2,
27
] | 3 | [] | [] | 0 | true | Family | Conserved hypothetical protein CHP02117 | Conserved hypothetical protein CHP02117 | CHP02117 | 1 |
IPR011728 | 11,728 | Polyhydroxyalkanoic acid inclusion protein PhaP | PhaP_Bmeg | Family | 273 | false | false | This entry describes a protein found in polyhydroxyalkanoic acid (PHA) gene regions and incorporated into PHA inclusions in Bacillus cereus and Bacillus megaterium. The role of the protein may include amino acid storage [ ]. | [] | [] | [] | 0 | [
"PFAM",
"NCBIFAM"
] | [
"PF09602",
"TIGR02131"
] | [
"PhaP_Bmeg",
"phaP_Bmeg"
] | [
273,
169
] | 2 | [
"GP"
] | [
"GenProp0055"
] | [
"GP:GenProp0055"
] | 1 | [] | 0 | [
"PUB00015304"
] | [
"9882674"
] | [
"Polyhydroxyalkanoate inclusion body-associated proteins and coding region in Bacillus megaterium."
] | [
1999
] | 1 | [] | [] | 0 | 0 | null | [
"Bacillota"
] | [
273
] | 1 | [] | [] | 0 | true | Family | Polyhydroxyalkanoic acid inclusion protein PhaP | Polyhydroxyalkanoic acid inclusion protein PhaP | PhaP_Bmeg | 1 |
IPR011729 | 11,729 | Polyhydroxyalkanoic acid synthase, PhaR subunit | PhaR_Bmeg_synth | Family | 199 | false | false | This entry describes a protein, PhaR, localized to polyhydroxyalkanoic acid (PHA) inclusion granules in Bacillus cereus and related species. PhaR is required for PHA biosynthesis along with PhaC and may be a regulatory subunit [ ]. | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"TIGR02132"
] | [
"phaR_Bmeg"
] | [
199
] | 1 | [
"GP"
] | [
"GenProp0055"
] | [
"GP:GenProp0055"
] | 1 | [] | 0 | [
"PUB00013497"
] | [
"11418564"
] | [
"PhaC and PhaR are required for polyhydroxyalkanoic acid synthase activity in Bacillus megaterium."
] | [
2001
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria"
] | [
199
] | 1 | [] | [] | 0 | true | Family | Polyhydroxyalkanoic acid synthase, PhaR subunit | Polyhydroxyalkanoic acid synthase, PhaR subunit | PhaR_Bmeg_synth | 9 |
IPR011732 | 11,732 | Mycoplasma virulence, signal domain | Mycoplasma_virulence_signal | Domain | 84 | false | false | This entry represents the N-terminal region of a family of large, virulence-associated proteins in Mycoplasma arthritidis and smaller proteins in Mycoplasma capricolum. It includes a probable signal sequence or signal anchor, which, in most instances, has four consecutive Lys residues before the hydrophobic stretch. | [] | [] | [] | 0 | [
"PFAM",
"NCBIFAM"
] | [
"PF09610",
"TIGR02184"
] | [
"Myco_arth_vir_N",
"Myco_arth_vir_N"
] | [
78,
74
] | 2 | [] | [] | [] | 0 | [
"7adk",
"7adm"
] | 2 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria"
] | [
84
] | 1 | [] | [] | 0 | true | Domain | Mycoplasma virulence, signal domain | Mycoplasma virulence, signal domain | Mycoplasma_virulence_signal | 2 |
IPR011733 | 11,733 | Conserved hypothetical CHP02185, integral membrane | CHP02185_IM | Family | 3,013 | false | false | This family consists of strongly hydrophobic proteins about 190 amino acids in length with a strongly basic motif near the C terminus. If is found in rather few species, but in paralogous families of 12 members in the oral pathogenic spirochaete Treponema denticola and 2 in Streptococcus pneumoniae (strain ATCC BAA-255... | [] | [] | [] | 0 | [
"PFAM",
"NCBIFAM"
] | [
"PF09605",
"TIGR02185"
] | [
"Trep_Strep",
"Trep_Strep"
] | [
3013,
2820
] | 2 | [
"GP"
] | [
"GenProp1094"
] | [
"GP:GenProp1094"
] | 1 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Methanobacteriaceae",
"metagenomes"
] | [
2969,
21,
23
] | 3 | [] | [] | 0 | true | Family | Conserved hypothetical CHP02185, integral membrane | Conserved hypothetical CHP02185, integral membrane | CHP02185_IM | 1 |
IPR011735 | 11,735 | WlaTC/HtrL glycosyltransferase | WlaTC/HtrL_glycosyltransf | Family | 1,239 | false | false | This family includes HtrL (also known as YibB) in Escherichia coli, where its gene is found in a region of LPS core biosynthesis genes [ ]. Homologues are found in Shigella flexneri, Campylobacter jejuni, and some eukaryotic species, such as Caenorhabditis elegans. WlaTC from Campylobacter jejuni, is involved in lipool... | [] | [] | [] | 0 | [
"PFAM",
"NCBIFAM"
] | [
"PF09612",
"TIGR02192"
] | [
"HtrL_YibB",
"HtrL_YibB"
] | [
1239,
299
] | 2 | [] | [] | [] | 0 | [] | 0 | [
"PUB00015305",
"PUB00102307"
] | [
"8157607",
"22445818"
] | [
"Molecular analysis of the rfaD gene, for heptose synthesis, and the rfaF gene, for heptose transfer, in lipopolysaccharide synthesis in Salmonella typhimurium.",
"The role of WlaRG, WlaTB and WlaTC in lipooligosaccharide synthesis by Campylobacter jejuni strain 81116."
] | [
1994,
2012
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Viruses",
"metagenomes"
] | [
401,
691,
15,
132
] | 4 | [
"Caenorhabditis elegans",
"Escherichia coli (strain K12)"
] | [
1,
1
] | 2 | true | Family | WlaTC/HtrL glycosyltransferase | WlaTC/HtrL glycosyltransferase | WlaTC/HtrL_glycosyltransf | 2 |
IPR011736 | 11,736 | Ehrlichia tandem repeat | Ehrlichia_tandem_rpt | Repeat | 12 | false | false | This entry represents 77 residues of an 80 amino acid (240 nucleotide) tandem repeat, found in a variable number of copies in an immunodominant outer membrane protein of Ehrlichia chaffeensis, a tick-borne obligate intracellular pathogen [ ]. | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"TIGR02202"
] | [
"Ehrlichia_rpt"
] | [
12
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00013006"
] | [
"12496165"
] | [
"Molecular heterogeneity of Ehrlichia chaffeensis isolates determined by sequence analysis of the 28-kilodalton outer membrane protein genes and other regions of the genome."
] | [
2003
] | 1 | [] | [] | 0 | 0 | null | [
"Ehrlichia chaffeensis"
] | [
12
] | 1 | [] | [] | 0 | true | Repeat | Ehrlichia tandem repeat | Ehrlichia tandem repeat | Ehrlichia_tandem_rpt | 7 |
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