LiteFold/InterPro · Datasets at Hugging Face

IPR011440

11,440

Domain of unknown function DUF1543

DUF1543

Domain

1,705

false

This domain is found as 1-2 copies in a small family of proteins of unknown function.

[]

0

[ "PFAM" ]

[ "PF07566" ]

[ "DUF1543" ]

[ 1705 ]

1

[]

0

[ "2qsd" ]

1

[]

0

[]

0

null

[ "Bacteria", "Orpheovirus IHUMI-LCC2", "Pararge aegeria aegeria", "metagenomes" ]

[ 1682, 1, 1, 21 ]

4

[]

0

true

Domain

Domain of unknown function DUF1543

DUF1543

5

IPR011442

11,442

TAF6, C-terminal HEAT repeat domain

TAF6_C

Domain

6,087

false

This is the C-terminal domain of the TAF6 subunit of the general transcription factor TFIID. The crystal structure reveals the presence of five conserved HEAT repeats. This region is necessary for the complexing together of the subunits TAF5, TAF6 and TAF9 [ , ].

[ "GO:0006367" ]

[ "transcription initiation at RNA polymerase II promoter" ]

[ "biological_process" ]

1

[ "PFAM", "CDD" ]

[ "PF07571", "cd08050" ]

[ "TAF6_C", "TAF6C" ]

[ 6083, 5901 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-DME-674695", "R-DME-6804756", "R-DME-6807505", "R-DME-73776", "R-DME-73779", "R-DME-75953", "R-DME-76042", "R-HSA-167161", "R-HSA-167162", "R-HSA-167172", "R-HSA-3214847", "R-HSA-674695", "R-HSA-6804756", "R-HSA-6807505", "R-HSA-73776", "R-HSA-73779", "R-HSA-75953", "R-HSA-76042...

[ "REACTOME:R-DME-674695", "REACTOME:R-DME-6804756", "REACTOME:R-DME-6807505", "REACTOME:R-DME-73776", "REACTOME:R-DME-73779", "REACTOME:R-DME-75953", "REACTOME:R-DME-76042", "REACTOME:R-HSA-167161", "REACTOME:R-HSA-167162", "REACTOME:R-HSA-167172", "REACTOME:R-HSA-3214847", "REACTOME:R-HSA-6746...

44

[ "4atg", "5fur", "6hqa", "6mzc", "6mzd", "6mzl", "6mzm", "6t9i", "6t9k", "6tb4", "6tbm", "7edx", "7eg7", "7eg8", "7eg9", "7ega", "7egb", "7egc", "7egd", "7ege", "7egf", "7egg", "7egh", "7egi", "7egj", "7ena", "7enc", "7ktr", "8gxq", "8gxs", "8h7g", "8wak"...

39

[ "PUB00075536", "PUB00099783" ]

[ "22696218", "29485702" ]

[ "TFIID TAF6-TAF9 complex formation involves the HEAT repeat-containing C-terminal domain of TAF6 and is modulated by TAF5 protein.", "Mutational analysis of TAF6 revealed the essential requirement of the histone-fold domain and the HEAT repeat domain for transcriptional activation." ]

[ 2012, 2018 ]

2

[]

0

null

[ "Eukaryota", "bird metagenome" ]

[ 6086, 1 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 13, 5, 8, 8, 12, 7, 1, 2, 8, 1, 1, 9 ]

12

true

Domain

TAF6, C-terminal HEAT repeat domain

TAF6_C

8

IPR011443

11,443

Domain of unknown function DUF1547

DUF1547

Domain

112

false

This domain appears to be found only in a small family of Chlamydia species [ ]. It is usually found repeated. This domain can be found in translocated actin-recruiting phosphoprotein (Tarp) from Chlamydia trachomatis serovar L2. Tarp appears to initiate or participate in signalling events that regulate the actin recru...

[]

0

[ "PFAM" ]

[ "PF07577" ]

[ "DUF1547" ]

[ 112 ]

1

[]

0

[]

0

[ "PUB00075564", "PUB00097825" ]

[ "15199184", "22506068" ]

[ "A chlamydial type III translocated protein is tyrosine-phosphorylated at the site of entry and associated with recruitment of actin.", "The Chlamydia psittaci genome: a comparative analysis of intracellular pathogens." ]

[ 2004, 2012 ]

2

[]

0

null

[ "Chlamydia" ]

[ 112 ]

1

[]

0

true

Domain

Domain of unknown function DUF1547

DUF1547

8

IPR011444

11,444

Domain of unknown function DUF1549

DUF1549

Domain

8,589

false

The function is not known. It is found associated with . It is also found associated with the Planctomycete cytochrome C domain .

[]

0

[ "PFAM" ]

[ "PF07583" ]

[ "PSCyt2" ]

[ 8589 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 3, 8219, 42, 325 ]

4

[]

0

true

Domain

Domain of unknown function DUF1549

DUF1549

5

IPR011446

11,446

Putative beta barrel porin-7

BBP7

Family

560

false

This is a family of putative β barrel porin-7 BBP7 proteins identified initially in Rhodopirellula baltica including .

[]

0

[ "PFAM" ]

[ "PF07585" ]

[ "BBP7" ]

[ 560 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "ecological metagenomes" ]

[ 557, 3 ]

2

[]

0

true

Family

Putative beta barrel porin-7

BBP7

9

IPR011447

11,447

Protein of unknown function DUF1552

DUF1552

Family

3,323

false

This is a family of uncharacterised proteins first identified in the Planctomycete Rhodopirellula baltica.

[]

0

[ "PFAM" ]

[ "PF07586" ]

[ "HXXSHH" ]

[ 3323 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 3068, 8, 247 ]

3

[]

0

true

Family

Protein of unknown function DUF1552

DUF1552

6

IPR011448

11,448

Domain of unknown function DUF1554

DUF1554

Domain

953

false

This is a domain that occurs in 1-2 copies in a family of proteins identified in Leptospira interrogans and other bacteria. The function of the proteins is not known.

[]

0

[ "PFAM" ]

[ "PF07588" ]

[ "DUF1554" ]

[ 953 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Sar", "marine metagenome" ]

[ 945, 7, 1 ]

3

[]

0

true

Domain

Domain of unknown function DUF1554

DUF1554

4

IPR011457

11,457

Protein of unknown function DUF1563

DUF1563

Family

107

false

This family of proteins is functionally uncharacterised.

[]

0

[ "PFAM" ]

[ "PF07599" ]

[ "DUF1563" ]

[ 107 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Caenorhabditis remanei" ]

[ 105, 2 ]

2

[]

0

true

Family

Protein of unknown function DUF1563

DUF1563

5

IPR011458

11,458

Protein of unknown function DUF1564

DUF1564

Family

1,555

false

This is a family of paralogous proteins in Leptospiraceae. One of them (e.g. ) have been annotated as possible CopG-like transcriptional regulators (see ).

[]

0

[ "PFAM" ]

[ "PF07600" ]

[ "DUF1564" ]

[ 1555 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Leptospiraceae" ]

[ 1555 ]

1

[]

0

true

Family

Protein of unknown function DUF1564

DUF1564

3

IPR011460

11,460

Lcl, C-terminal

Lcl_C

Domain

5,944

false

This domain, previously known as DUF1566, is found C-terminal in the Legionella collagen-like protein (Lcl) and related proteins mainly from bacteria. Lcl is an extracellular peripheral membrane protein that recognises sulphated glycosaminoglycans (GAGs) on the surface of eukaryotic cells, but also stimulates bacterial...

[]

0

[ "PFAM" ]

[ "PF07603" ]

[ "Lcl_C" ]

[ 5944 ]

1

[]

0

[ "8q4e", "8qk8" ]

2

[ "PUB00155456" ]

[ "38106198" ]

[ "The <i>Legionella</i> collagen-like protein employs a unique binding mechanism for the recognition of host glycosaminoglycans." ]

[ 2023 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Caudoviricetes", "Eukaryota", "unclassified sequences" ]

[ 20, 5585, 5, 23, 311 ]

5

[]

0

true

Domain

Lcl, C-terminal

Lcl_C

9

IPR011463

11,463

Protein of unknown function DUF1569

DUF1569

Family

2,484

false

This entry represents a family of hypothetical proteins identified in Rhodopirellula baltica and other bacteria.

[]

0

[ "PFAM" ]

[ "PF07606" ]

[ "DUF1569" ]

[ 2484 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "ecological metagenomes" ]

[ 2464, 9, 11 ]

3

[]

0

true

Family

Protein of unknown function DUF1569

DUF1569

8

IPR011464

11,464

Domain of unknown function DUF1570

DUF1570

Domain

718

false

This entry represents hypothetical proteins confined to bacteria.

[]

0

[ "PFAM" ]

[ "PF07607" ]

[ "DUF1570" ]

[ 718 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Cladocopium goreaui", "ecological metagenomes" ]

[ 703, 1, 14 ]

3

[]

0

true

Domain

Domain of unknown function DUF1570

DUF1570

1

IPR011465

11,465

Protein of unknown function DUF1571

DUF1571

Family

883

false

This is a family of paralogous proteins found in Planctomycetacia and Betaproteobacteria.

[]

0

[ "PFAM" ]

[ "PF07608" ]

[ "DUF1571" ]

[ 883 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Durusdinium trenchii", "ecological metagenomes" ]

[ 873, 1, 9 ]

3

[]

0

true

Family

Protein of unknown function DUF1571

DUF1571

1

IPR011466

11,466

Protein of unknown function DUF1572

DUF1572

Family

3,038

false

This protein represents proteins with unknown function found in several diverse bacteria.

[]

0

[ "PFAM" ]

[ "PF07609" ]

[ "DUF1572" ]

[ 3038 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "ecological metagenomes", "miscellaneous Crenarchaeota group-15 archaeon DG-45" ]

[ 3022, 15, 1 ]

3

[]

0

true

Family

Protein of unknown function DUF1572

DUF1572

9

IPR011467

11,467

Protein of unknown function DUF1573

DUF1573

Domain

8,528

false

These hypothetical proteins from bacteria, such as Rhodopirellula baltica, Bacteroides thetaiotaomicron and Porphyromonas gingivalis, share a region of conserved sequence towards their N termini.

[]

0

[ "PFAM" ]

[ "PF07610" ]

[ "DUF1573" ]

[ 8528 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified Caudoviricetes", "unclassified sequences", "uncultured haloarchaeon" ]

[ 8357, 10, 3, 157, 1 ]

5

[]

0

true

Domain

Protein of unknown function DUF1573

DUF1573

5

IPR011468

11,468

Protein of unknown function DUF1574

DUF1574

Family

758

false

This is a family of hypothetical proteins found in Leptospira interrogans and other bacteria.

[]

0

[ "PFAM" ]

[ "PF07611" ]

[ "DUF1574" ]

[ 758 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "marine metagenome" ]

[ 756, 2 ]

2

[]

0

true

Family

Protein of unknown function DUF1574

DUF1574

1

IPR011470

11,470

Protein of unknown function DUF1576

DUF1576

Family

772

false

This small family has no known function. Their sequences frequently contain conserved glycine and aromatic residues.

[]

0

[ "PFAM" ]

[ "PF07613" ]

[ "DUF1576" ]

[ 772 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Methanobacteriota", "bioreactor metagenome" ]

[ 756, 3, 13 ]

3

[]

0

true

Family

Protein of unknown function DUF1576

DUF1576

4

IPR011471

11,471

Protein of unknown function DUF1577

DUF1577

Family

640

false

This is a family of hypothetical proteins found in Leptospiraceae.

[]

0

[ "PFAM" ]

[ "PF07614" ]

[ "DUF1577" ]

[ 640 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "marine sediment metagenome" ]

[ 638, 2 ]

2

[]

0

true

Family

Protein of unknown function DUF1577

DUF1577

9

IPR011473

11,473

Protein of unknown function DUF1579

DUF1579

Family

2,176

false

This is a family of paralogous hypothetical proteins identified in Rhodopirellula baltica that also has members in Gloeobacter violaceus, Rhizobium meliloti and Agrobacterium tumefaciens, amongst others.

[]

0

[ "PFAM" ]

[ "PF07617" ]

[ "DUF1579" ]

[ 2176 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Methanomicrobia", "ecological metagenomes" ]

[ 2155, 4, 5, 12 ]

4

[]

0

true

Family

Protein of unknown function DUF1579

DUF1579

5

IPR011474

11,474

Protein of unknown function DUF1580

DUF1580

Family

166

false

This is a family of short hypothetical proteins found in Rhodopirellula baltica.

[]

0

[ "PFAM" ]

[ "PF07618" ]

[ "DUF1580" ]

[ 166 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Eukaryota", "Pseudomonadati", "marine sediment metagenome", "uncultured Caudovirales phage" ]

[ 2, 162, 1, 1 ]

4

[]

0

true

Family

Protein of unknown function DUF1580

DUF1580

6

IPR011475

11,475

Domain of unknown function DUF1583

DUF1583

Domain

131

false

This entry represents a domain mainly found in bacterial proteins from Planctomycetia. Many of the Rhodopirellula baltica hypothetical proteins that have this domain also match .

[]

0

[ "PFAM" ]

[ "PF07622" ]

[ "DUF1583" ]

[ 131 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Durusdinium trenchii", "marine sediment metagenome" ]

[ 129, 1, 1 ]

3

[]

0

true

Domain

Domain of unknown function DUF1583

DUF1583

7

IPR011476

11,476

Protein of unknown function DUF1582

DUF1582

Family

19

false

This is a family of hypothetical proteins found in Rhodopirellula.

[]

0

[ "PFAM" ]

[ "PF07621" ]

[ "DUF1582" ]

[ 19 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Rhodopirellula" ]

[ 19 ]

1

[]

0

true

Family

Protein of unknown function DUF1582

DUF1582

9

IPR011478

11,478

Domain of unknown function DUF1585

DUF1585

Domain

2,907

false

This entry represents a conserved region at the C terminus of a family of cytochrome-like proteins found in bacteria such as Rhodopirellula baltica and Solibacter usitatus. These proteins also contain , , and .

[]

0

[ "PFAM" ]

[ "PF07624" ]

[ "PSD2" ]

[ 2907 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "ecological metagenomes" ]

[ 2773, 6, 128 ]

3

[]

0

true

Domain

Domain of unknown function DUF1585

DUF1585

4

IPR011480

11,480

Protein of unknown function DUF1589

DUF1589

Family

27

false

This is a family of short hypothetical proteins found in Rhodopirellula baltica.

[]

0

[ "PFAM" ]

[ "PF07628" ]

[ "DUF1589" ]

[ 27 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria" ]

[ 27 ]

1

[]

0

true

Family

Protein of unknown function DUF1589

DUF1589

4

IPR011483

11,483

Cellulose-binding Sde182, nucleoside hydrolase-like domain

Sde182_NH-like

Domain

3,382

false

This entry represents a Rossmann-related domain found in bacterial and fungal proteins, including Cellulose-binding protein from Saccharophagus degradans ( ). This protein, which seems to have capacity to bind plant carbohydrates, contain carbohydrate-binding modules (CBMs) together with a C-terminal domain of unknown ...

[]

0

[ "PFAM" ]

[ "PF07632" ]

[ "Sde182_NH-like" ]

[ 3382 ]

1

[]

0

[ "2yhg" ]

1

[ "PUB00100688" ]

[ "21905122" ]

[ "Ab initio phasing of a nucleoside hydrolase-related hypothetical protein from Saccharophagus degradans that is associated with carbohydrate metabolism." ]

[ 2011 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "Halobacteriales", "metagenomes" ]

[ 1822, 1545, 2, 13 ]

4

[]

0

true

Domain

Cellulose-binding Sde182, nucleoside hydrolase-like domain

Sde182_NH-like

4

IPR011486

11,486

Putative beta-barrel porin-2, OmpL-like bbp2

BBP2

Family

4,340

false

BBP2 is a family of putative porin proteins that are likely to be outer membrane β-barrel proteins porins.

[]

0

[ "PFAM" ]

[ "PF07642" ]

[ "BBP2" ]

[ 4340 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 4260, 8, 72 ]

3

[]

0

true

Family

Putative beta-barrel porin-2, OmpL-like bbp2

BBP2

4

IPR011491

11,491

Flagellar hook protein FlgE, D2 domain

FlgE_D2

Domain

10,910

false

This domain is found in several bacterial FlgE flagellar hook proteins [ ]. The flagellar hook is a short, curved, extracellular structure located between the basal body and the filament [ ].

[]

0

[ "PFAM" ]

[ "PF07559" ]

[ "FlgE_D2" ]

[ 10910 ]

1

[ "GP" ]

[ "GenProp0882" ]

[ "GP:GenProp0882" ]

1

[ "1wlg", "2bgy", "2bgz", "3a69", "5ay6", "5az4", "5jxl", "6jzt", "6k3i", "6k9q", "6kfk", "6ndt", "6ndv", "6ndw", "6ndx", "7cbm", "7cgb", "7cgo", "7e80", "7e82", "8wki", "8wkk", "8wl2", "8wlp", "8wlq", "8wlt", "8wo5", "8woe", "8z5u", "8z5y", "8z5z", "8z60"...

33

[ "PUB00076716", "PUB00076717" ]

[ "23749974", "10869084" ]

[ "Length control of the flagellar hook in a temperature-sensitive flgE mutant of Salmonella enterica serovar Typhimurium.", "The flagellar hook protein, FlgE, of Salmonella enterica serovar typhimurium is posttranscriptionally regulated in response to the stage of flagellar assembly." ]

[ 2013, 2000 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "Myoviridae sp. ct2AC8", "unclassified sequences" ]

[ 10760, 30, 1, 119 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Domain

Flagellar hook protein FlgE, D2 domain

FlgE_D2

9

IPR011492

11,492

Non-structural protein NS3-like, DEAD-box helicase, flavivirus

Flavi_DEAD

Domain

37,323

false

The non-structural protein NS3 from flavivirus is a bifunctional protein that contains an N-terminal protease ( ) and a C-terminal helicase domains that plays an essential role in viral polyprotein processing and genome replication. The N-terminal domain is a chymotrypsin-like serine protease, which is responsible for ...

[ "GO:0004386", "GO:0005524" ]

[ "helicase activity", "ATP binding" ]

[ "molecular_function", "molecular_function" ]

2

[ "PFAM" ]

[ "PF07652" ]

[ "Flavi_DEAD" ]

[ 37323 ]

1

[ "EC", "EC", "EC", "EC", "EC", "EC", "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "REACTOME", "REACTOME" ]

[ "2.1.1.56", "2.1.1.57", "2.7.7.48", "3.4.21", "3.4.21.91", "3.6.1.15", "3.6.4.13", "PWY-6545", "PWY-7184", "PWY-7185", "PWY-7198", "PWY-7210", "PWY-7375", "PWY-7379", "R-HSA-5621480", "R-HSA-8854214" ]

[ "EC:2.1.1.56", "EC:2.1.1.57", "EC:2.7.7.48", "EC:3.4.21", "EC:3.4.21.91", "EC:3.6.1.15", "EC:3.6.4.13", "METACYC:PWY-6545", "METACYC:PWY-7184", "METACYC:PWY-7185", "METACYC:PWY-7198", "METACYC:PWY-7210", "METACYC:PWY-7375", "METACYC:PWY-7379", "REACTOME:R-HSA-5621480", "REACTOME:R-HSA-...

16

[ "1a1v", "1cu1", "1hei", "1yks", "2bhr", "2bmf", "2f55", "2jlq", "2jlr", "2jls", "2jlu", "2jlv", "2jlw", "2jlx", "2jly", "2jlz", "2qeq", "2v6i", "2v6j", "2v8o", "2vbc", "2whx", "2wv9", "2wzq", "2z83", "2zjo", "3kqh", "3kqk", "3kql", "3kqn", "3kqu", "3o8b"...

161

[ "PUB00103480" ]

[ "30951555" ]

[ "Supramolecular arrangement of the full-length Zika virus NS5." ]

[ 2019 ]

1

[ "IPR014001" ]

[]

1

0

1

[ "Clostridium aciditolerans", "Ecdysozoa", "Viruses", "bird metagenome" ]

[ 1, 14, 37307, 1 ]

4

[]

0

true

Domain

Non-structural protein NS3-like, DEAD-box helicase, flavivirus

Flavi_DEAD

2

IPR011493

11,493

GLUG

Domain

2,629

false

This domain is found in the IgA1-specific metalloendopeptidases, which attach to the cell wall peptidoglycan by an amide bond [ ]. IgA1 protease selectively cleaves human IgA1 and is likely to be a pathogenicity factor in some pathogens including Giardia spp [ ]. This domain is also found in various other contexts, inc...

[]

0

[ "PFAM" ]

[ "PF07581" ]

[ "Glug" ]

[ 2629 ]

1

[]

0

[ "6xja", "6xjb", "7jgj", "7uvk", "7uvl" ]

5

[ "PUB00014733", "PUB00014734" ]

[ "8926055", "12841855" ]

[ "Characterization of the Streptococcus pneumoniae immunoglobulin A1 protease gene (iga) and its translation product.", "The three extra-cellular zinc metalloproteinases of Streptococcus pneumoniae have a different impact on virulence in mice." ]

[ 1996, 2003 ]

2

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "metagenomes" ]

[ 240, 2288, 14, 87 ]

4

[ "Arabidopsis thaliana" ]

[ 1 ]

1

true

Domain

GLUG

1

IPR011494

11,494

Protein HIRA-like, C-terminal

HIRA-like_C

Domain

5,045

false

This entry represents a domain found at the C-terminal end of the HIRA proteins, which mediates homooligomerization [ ]. The Hira proteins are found in a range of eukaryotes and are implicated in the assembly of repressive chromatin, including Hir1/2 from yeast and the orthologue from human, HIRA (also known as TUP1-li...

[ "GO:0006338", "GO:0006355" ]

[ "chromatin remodeling", "regulation of DNA-templated transcription" ]

[ "biological_process", "biological_process" ]

2

[ "PFAM" ]

[ "PF07569" ]

[ "Hira" ]

[ 5045 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-CEL-2559584", "R-HSA-2559584", "R-HSA-9821993", "R-MMU-2559584", "R-SCE-2559584" ]

[ "REACTOME:R-CEL-2559584", "REACTOME:R-HSA-2559584", "REACTOME:R-HSA-9821993", "REACTOME:R-MMU-2559584", "REACTOME:R-SCE-2559584" ]

5

[ "5yje", "8gha", "8ghl", "8ghm", "8ghn" ]

5

[ "PUB00019699", "PUB00043990", "PUB00077872", "PUB00103531", "PUB00103532", "PUB00103806" ]

[ "8681138", "16980972", "14718166", "15621527", "12370293", "30082790" ]

[ "Structural Organization of the WD repeat protein-encoding gene HIRA in the DiGeorge syndrome critical region of human chromosome 22.", "Structure of a human ASF1a-HIRA complex and insights into specificity of histone chaperone complex assembly.", "Histone H3.1 and H3.3 complexes mediate nucleosome assembly pat...

[ 1996, 2006, 2004, 2005, 2002, 2018 ]

6

[]

0

null

[ "Eukaryota" ]

[ 5045 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 5, 2, 1, 1, 4, 1, 1, 1, 6, 2, 2, 13 ]

12

true

Domain

Protein HIRA-like, C-terminal

HIRA-like_C

8

IPR011495

11,495

Signal transduction histidine kinase, subgroup 2, dimerisation and phosphoacceptor domain

Sig_transdc_His_kin_sub2_dim/P

Domain

19,021

false

This is the dimerisation and phosphoacceptor domain of a subfamily of histidine kinases. It shares sequence similarity with and . It is usually found adjacent to a C-terminal ATPase domain ( ). This domain is found in a wide range of bacteria and also several archaea. Two-component signal transduction systems enable ba...

[]

0

[ "PFAM" ]

[ "PF07568" ]

[ "HisKA_2" ]

[ 19021 ]

1

[ "EC", "GP" ]

[ "2.7.13.3", "GenProp0292" ]

[ "EC:2.7.13.3", "GP:GenProp0292" ]

2

[ "4r39", "4r3a" ]

2

[ "PUB00000966", "PUB00007866", "PUB00010651", "PUB00011096", "PUB00013246", "PUB00013247", "PUB00013562", "PUB00013563", "PUB00020801", "PUB00042804", "PUB00042805", "PUB00042806", "PUB00042807" ]

[ "9989504", "11406410", "12372152", "10966457", "8868347", "10426948", "8029829", "1482126", "11145881", "16176121", "18076326", "11934609", "11489844" ]

[ "Structure of CheA, a signal-transducing histidine kinase.", "Histidine kinases and response regulator proteins in two-component signaling systems.", "Histidine protein kinases: key signal transducers outside the animal kingdom.", "Two-component signal transduction.", "Protein aspartate phosphatases control...

[ 1999, 2001, 2002, 2000, 1996, 1999, 1994, 1992, 2000, 2005, 2007, 2002, 2001 ]

13

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "metagenomes" ]

[ 1491, 17187, 8, 335 ]

4

[]

0

true

Domain

Signal transduction histidine kinase, subgroup 2, dimerisation and phosphoacceptor domain

Sig_transdc_His_kin_sub2_dim/P

7

IPR011496

11,496

Beta-N-acetylglucosaminidase, catalytic domain

O-GlcNAcase_cat

Domain

6,586

false

This entry represents the catalytic domain found at the N-terminal of the human protein O-GlcNAcase (OGA), O-GlcNAcase BT_4395 from Bacteroides thetaiotaomicron, Hyaluronoglucosaminidase from Clostridium perfringens (NagH) and similar sequences from eukaryotes and bacteria. OGA and BT_4395 cleave GlcNAc but not GalNAc ...

[]

0

[ "PFAM", "PROFILE" ]

[ "PF07555", "PS52009" ]

[ "NAGidase", "GH84" ]

[ 6560, 6572 ]

2

[ "EC", "GP", "METACYC" ]

[ "3.2.1.169", "GenProp1442", "PWY-7437" ]

[ "EC:3.2.1.169", "GP:GenProp1442", "METACYC:PWY-7437" ]

3

[ "2cbi", "2cbj", "2chn", "2cho", "2j47", "2j4g", "2j62", "2jiw", "2v5c", "2v5d", "2vur", "2vvn", "2vvs", "2w4x", "2w66", "2w67", "2wb5", "2wca", "2wzh", "2wzi", "2x0h", "2x0y", "2xj7", "2xm1", "2xm2", "2xpk", "2xsa", "2xsb", "2ydq", "2ydr", "2yds", "4ais"...

82

[ "PUB00014736", "PUB00039957", "PUB00040021", "PUB00152858", "PUB00152859", "PUB00152860", "PUB00153252", "PUB00153253", "PUB00153254" ]

[ "8177218", "16541109", "16565725", "11148210", "28319083", "28346405", "16533067", "26491011", "31701135" ]

[ "Molecular genetic analysis of the nagH gene encoding a hyaluronidase of Clostridium perfringens.", "Structural insights into the mechanism and inhibition of eukaryotic O-GlcNAc hydrolysis.", "Structure and mechanism of a bacterial beta-glucosaminidase having O-GlcNAcase activity.", "Dynamic O-glycosylation o...

[ 1994, 2006, 2006, 2001, 2017, 2017, 2006, 2015, 2019 ]

9

[]

0

null

[ "Bacteria", "Eukaryota", "Thermoproteota", "unclassified sequences" ]

[ 3068, 3445, 4, 69 ]

4

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 4, 5, 1, 3, 4, 5 ]

6

true

Domain

Beta-N-acetylglucosaminidase, catalytic domain

O-GlcNAcase_cat

3

IPR011498

11,498

Kelch repeat type 2

Kelch_2

Repeat

6,632

false

Kelch is a 50-residue motif, named after the Drosophila mutant in which it was first identified [ ]. This sequence motif represents one β-sheet blade, and several of these repeats can associate to form a β-propeller. For instance, the motif appears 6 times in Drosophila egg-chamber regulatory protein (also known as rin...

[ "GO:0005515" ]

[ "protein binding" ]

[ "molecular_function" ]

1

[ "PFAM" ]

[ "PF07646" ]

[ "Kelch_2" ]

[ 6632 ]

1

[]

0

[ "5lqi", "5lxz", "7kzm", "7kzn", "8glv", "8voj", "8vpq", "8vrt", "9dtg", "9dtq", "9g43", "9g8h", "9ggl", "9ggm", "9ggn", "9i2c" ]

16

[ "PUB00000885", "PUB00003079", "PUB00003094", "PUB00003318", "PUB00003324", "PUB00004093" ]

[ "8453663", "7822422", "7593276", "8126718", "8182749", "2002850" ]

[ "kelch encodes a component of intercellular bridges in Drosophila egg chambers.", "Sequence and domain organization of scruin, an actin-cross-linking protein in the acrosomal process of Limulus sperm.", "beta-Scruin, a homologue of the actin crosslinking protein scruin, is localized to the acrosomal vesicle of ...

[ 1993, 1995, 1995, 1994, 1994, 1991 ]

6

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 627, 5999, 6 ]

3

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Zea mays" ]

[ 41, 4, 1, 2, 3, 10, 6, 1, 28 ]

9

true

Repeat

Kelch repeat type 2

Kelch_2

9

IPR011499

11,499

Lipid A biosynthesis, N-terminal

Lipid_A_biosynth_N

Domain

2,493

false

This domain is found at the N terminus of a group of Chlamydial lipid A biosynthesis proteins. It is also found by itself in a family of proteins of unknown function.

[ "GO:0008915", "GO:0009245" ]

[ "lipid-A-disaccharide synthase activity", "lipid A biosynthetic process" ]

[ "molecular_function", "biological_process" ]

2

[ "PFAM", "SMART" ]

[ "PF07578", "SM01259" ]

[ "LAB_N", "LAB_N" ]

[ 2483, 2483 ]

2

[ "EC", "METACYC", "METACYC", "METACYC" ]

[ "2.4.1.182", "PWY-8073", "PWY-8245", "PWY-8283" ]

[ "EC:2.4.1.182", "METACYC:PWY-8073", "METACYC:PWY-8245", "METACYC:PWY-8283" ]

4

[]

0

[]

0

[]

0

null

[ "Bacteria", "Knufia peltigerae", "Thermococcus", "unclassified sequences" ]

[ 2448, 1, 3, 41 ]

4

[]

0

true

Domain

Lipid A biosynthesis, N-terminal

Lipid_A_biosynth_N

6

IPR011500

11,500

GPCR, family 3, nine cysteines domain

GPCR_3_9-Cys_dom

Domain

32,348

false

G protein-coupled receptors (GPCRs) constitute a vast protein family that encompasses a wide range of functions, including various autocrine, paracrine and endocrine processes. They show considerable diversity at the sequence level, on the basis of which they can be separated into distinct groups [ ]. The term clan can...

[ "GO:0004930", "GO:0007186" ]

[ "G protein-coupled receptor activity", "G protein-coupled receptor signaling pathway" ]

[ "molecular_function", "biological_process" ]

2

[ "PFAM" ]

[ "PF07562" ]

[ "NCD3G" ]

[ 32348 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-416476", "R-BTA-418594", "R-BTA-420499", "R-CEL-418594", "R-CEL-420499", "R-DRE-416476", "R-DRE-420499", "R-HSA-416476", "R-HSA-418594", "R-HSA-420499", "R-HSA-6794361", "R-HSA-9717207", "R-MMU-416476", "R-MMU-418594", "R-MMU-420499", "R-MMU-6794361", "R-MMU-9717207", "R-RNO...

[ "REACTOME:R-BTA-416476", "REACTOME:R-BTA-418594", "REACTOME:R-BTA-420499", "REACTOME:R-CEL-418594", "REACTOME:R-CEL-420499", "REACTOME:R-DRE-416476", "REACTOME:R-DRE-420499", "REACTOME:R-HSA-416476", "REACTOME:R-HSA-418594", "REACTOME:R-HSA-420499", "REACTOME:R-HSA-6794361", "REACTOME:R-HSA-97...

25

[ "2e4u", "2e4v", "2e4w", "2e4x", "2e4y", "5k5s", "5k5t", "5kzn", "5kzq", "6n4x", "6n4y", "6n50", "6n51", "6n52", "7dd5", "7dd6", "7dd7", "7dgd", "7dge", "7dtt", "7dtu", "7dtv", "7dtw", "7e6t", "7e6u", "7e9g", "7e9h", "7epa", "7epb", "7epc", "7epd", "7fd8"...

121

[ "PUB00004161", "PUB00004309", "PUB00004961", "PUB00007343", "PUB00036049", "PUB00036050", "PUB00053635", "PUB00063577", "PUB00063578", "PUB00063579", "PUB00063580", "PUB00063816" ]

[ "8255296", "1309649", "8170923", "9292726", "17266540", "10773016", "12679517", "8081729", "15914470", "18948278", "16753280", "23020293" ]

[ "Cloning and characterization of an extracellular Ca(2+)-sensing receptor from bovine parathyroid.", "A family of metabotropic glutamate receptors.", "Fingerprinting G-protein-coupled receptors.", "A new multigene family of putative pheromone receptors.", "Structure, pharmacology and therapeutic prospects o...

[ 1993, 1992, 1994, 1997, 2007, 2000, 2003, 1994, 2005, 2009, 2006, 2013 ]

12

[]

0

null

[ "Eukaryota" ]

[ 32348 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 11, 137, 7, 51, 299, 195 ]

6

true

Domain

GPCR, family 3, nine cysteines domain

GPCR_3_9-Cys_dom

9

IPR011501

11,501

Nucleolar complex-associated protein 3, N-terminal

Noc3_N

Domain

4,502

false

This entry represents the N-terminal domain of the nucleolar complex-associated protein (Noc3), which is conserved in eukaryotes and plays essential roles in replication and rRNA processing in Saccharomyces cerevisiae [ ].

[]

0

[ "PFAM" ]

[ "PF07540" ]

[ "NOC3p" ]

[ 4502 ]

1

[]

0

[ "6elz", "6em5", "7nac", "7nad", "7ohr", "7r6k", "7r72", "7r7a", "8esq", "8esr", "8fkv", "8fkw", "8fkx", "8fky", "8i9v", "8i9w", "8i9x", "8i9y", "8i9z", "8ia0", "8v87" ]

21

[ "PUB00014737" ]

[ "12110182" ]

[ "Noc3p, a bHLH protein, plays an integral role in the initiation of DNA replication in budding yeast." ]

[ 2002 ]

1

[]

0

null

[ "Eukaryota" ]

[ 4502 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 5, 1, 1, 1, 3, 1, 1, 2, 3, 1, 1, 6 ]

12

true

Domain

Nucleolar complex-associated protein 3, N-terminal

Noc3_N

3

IPR011502

11,502

Nucleoporin Nup85-like

Nucleoporin_Nup85

Family

5,026

false

This is a family of nucleoporins conserved from yeast to human. Nup85 Nucleoporin is an essential component of the nuclear pore complex (NPC) that seems to be required for NPC assembly and maintenance. As part of the NPC Nup107-160 subcomplex plays a role in RNA export and in tethering NUP98/Nup98 and NUP153 to the nuc...

[]

0

[ "PFAM", "PANTHER" ]

[ "PF07575", "PTHR13373" ]

[ "Nucleopor_Nup85", "" ]

[ 4931, 4881 ]

2

[ "GP", "GP", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACT...

[ "GenProp2037", "GenProp2043", "R-BTA-141444", "R-BTA-159227", "R-BTA-159230", "R-BTA-159231", "R-BTA-159236", "R-BTA-170822", "R-BTA-191859", "R-BTA-2467813", "R-BTA-2500257", "R-BTA-3108214", "R-BTA-3232142", "R-BTA-3301854", "R-BTA-3371453", "R-BTA-4085377", "R-BTA-4551638", "R-B...

[ "GP:GenProp2037", "GP:GenProp2043", "REACTOME:R-BTA-141444", "REACTOME:R-BTA-159227", "REACTOME:R-BTA-159230", "REACTOME:R-BTA-159231", "REACTOME:R-BTA-159236", "REACTOME:R-BTA-170822", "REACTOME:R-BTA-191859", "REACTOME:R-BTA-2467813", "REACTOME:R-BTA-2500257", "REACTOME:R-BTA-3108214", "RE...

146

[ "3ewe", "3f3f", "3f3g", "3f3p", "4xmm", "4xmn", "4ycz", "5a9q", "6lk8", "6x08", "7fik", "7n84", "7n9f", "7peq", "7r5j", "7r5k", "7tbi", "7tbj", "7tbk", "7tbl", "7tbm", "7tdz", "7vci", "7vop", "7wb4", "8tie", "9hcj", "9sob" ]

28

[ "PUB00051815", "PUB00053585", "PUB00053586", "PUB00053587" ]

[ "18974315", "15995708", "12718872", "16807356" ]

[ "Structural evidence for common ancestry of the nuclear pore complex and vesicle coats.", "Pivotal function for cytoplasmic protein FROUNT in CCR2-mediated monocyte chemotaxis.", "Removal of a single pore subcomplex results in vertebrate nuclei devoid of nuclear pores.", "The Nup107-160 nucleoporin complex is...

[ 2008, 2005, 2003, 2006 ]

4

[]

0

null

[ "Clostridium putrefaciens", "Eukaryota" ]

[ 1, 5025 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 3, 1, 1, 8, 16, 3, 1, 5, 7, 1, 1, 13 ]

12

true

Family

Nucleoporin Nup85-like

Nucleoporin_Nup85

6

IPR011505

11,505

Peptidase M26, C-terminal domain

Peptidase_M26_C_dom

Domain

1,328

false

Over 70 metallopeptidase families have been identified to date. In these enzymes a divalent cation, which is usually zinc but may be cobalt, manganese or copper, activates the water molecule. The metal ion is held in place by amino acid ligands, usually three in number. In some families of co-catalytic metallopeptidase...

[ "GO:0004222", "GO:0008270", "GO:0005576", "GO:0005618" ]

[ "metalloendopeptidase activity", "zinc ion binding", "extracellular region", "cell wall" ]

[ "molecular_function", "molecular_function", "cellular_component", "cellular_component" ]

4

[ "PFAM" ]

[ "PF07580" ]

[ "Peptidase_M26_C" ]

[ 1328 ]

1

[ "EC" ]

[ "3.4.24" ]

[ "EC:3.4.24" ]

1

[ "6xja", "6xjb", "7jgj", "7uvk", "7uvl" ]

5

[ "PUB00003579", "PUB00014734", "PUB00036030" ]

[ "7674922", "12841855", "12933834" ]

[ "Evolutionary families of metallopeptidases.", "The three extra-cellular zinc metalloproteinases of Streptococcus pneumoniae have a different impact on virulence in mice.", "ZmpB, a novel virulence factor of Streptococcus pneumoniae that induces tumor necrosis factor alpha production in the respiratory tract." ...

[ 1995, 2003, 2003 ]

3

[]

0

null

[ "Bacteria" ]

[ 1328 ]

1

[]

0

true

Domain

Peptidase M26, C-terminal domain

Peptidase_M26_C_dom

4

IPR011506

11,506

Planctomycete extracellular

Planctomycete_extracellular

Domain

166

false

This motif is conserved at the N terminus of several Rhodopirellula baltica proteins predicted to be extracellular.

[]

0

[ "PFAM" ]

[ "PF07595" ]

[ "Planc_extracel" ]

[ 166 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Planctomycetia", "marine sediment metagenome" ]

[ 165, 1 ]

2

[]

0

true

Domain

Planctomycete extracellular

Planctomycete_extracellular

1

IPR011508

11,508

RSD-2, N-terminal

RSD-2_N

Domain

56

false

This domain is found in three copies at the N terminus of the Caenorhabditis elegans RSD-2 protein. RSD-2 (RNAi spreading defective) is involved in systemic RNAi [ ]. Mutations in the rsd-2 gene do not affect somatic genes but only germline expressed genes [ ].

[]

0

[ "PFAM" ]

[ "PF07547" ]

[ "RSD-2" ]

[ 56 ]

1

[]

0

[]

0

[ "PUB00014738" ]

[ "14738731" ]

[ "Genes required for systemic RNA interference in Caenorhabditis elegans." ]

[ 2004 ]

1

[]

0

null

[ "Caenorhabditis" ]

[ 56 ]

1

[ "Caenorhabditis elegans" ]

[ 5 ]

1

true

Domain

RSD-2, N-terminal

RSD-2_N

1

IPR011509

11,509

RtxA toxin

RtxA_toxin

Repeat

357

false

This short repeat is found in the RtxA toxin family [ ].

[]

0

[ "PFAM" ]

[ "PF07634" ]

[ "RtxA" ]

[ 357 ]

1

[]

0

[]

0

[ "PUB00014739" ]

[ "9927695" ]

[ "Identification of a vibrio cholerae RTX toxin gene cluster that is tightly linked to the cholera toxin prophage." ]

[ 1999 ]

1

[]

0

null

[ "Eukaryota", "Pseudomonadota" ]

[ 4, 353 ]

2

[]

0

true

Repeat

RtxA toxin

RtxA_toxin

1

IPR011513

11,513

Non-structural maintenance of chromosomes element 1

Nse1

Family

4,319

false

Saccharomyces cerevisiae Nse1 ( ) forms part of a complex with SMC5-SMC6. This non-structural maintenance of chromosomes (SMC) complex plays an essential role in genomic stability, being involved in DNA repair and DNA metabolism [ , ]. It is conserved in eukaryotes from yeast to human. Nse1 acts in a DNA repair pathway...

[ "GO:0006281", "GO:0030915" ]

[ "DNA repair", "Smc5-Smc6 complex" ]

[ "biological_process", "cellular_component" ]

2

[ "PFAM", "PANTHER" ]

[ "PF07574", "PTHR20973" ]

[ "SMC_Nse1", "" ]

[ 4092, 4227 ]

2

[ "EC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "2.3.2.27", "PWY-7511", "R-HSA-3108214", "R-MMU-3108214", "R-RNO-3108214", "R-SCE-3108214", "R-SPO-3108214" ]

[ "EC:2.3.2.27", "METACYC:PWY-7511", "REACTOME:R-HSA-3108214", "REACTOME:R-MMU-3108214", "REACTOME:R-RNO-3108214", "REACTOME:R-SCE-3108214", "REACTOME:R-SPO-3108214" ]

7

[ "2ct0", "5hvq", "5wy5", "7dg2", "7qcd", "7tve", "7ymd", "7yqh", "8hqs", "8i13", "8wjn" ]

11

[ "PUB00014740", "PUB00014741" ]

[ "12966087", "11927594" ]

[ "Novel essential DNA repair proteins Nse1 and Nse2 are subunits of the fission yeast Smc5-Smc6 complex.", "Identification of a novel non-structural maintenance of chromosomes (SMC) component of the SMC5-SMC6 complex involved in DNA repair." ]

[ 2003, 2002 ]

2

[]

0

null

[ "Eukaryota", "Streptomyces glaucosporus", "marine sediment metagenome" ]

[ 4317, 1, 1 ]

3

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 4, 1, 4, 2, 7, 3, 1, 6, 4, 1, 1, 7 ]

12

true

Family

Non-structural maintenance of chromosomes element 1

Nse1

4

IPR011514

11,514

Secretin, N-terminal

Secretin_N_2

Domain

2,882

false

This is a short domain found in bacterial type II/III secretory system proteins. The architecture of these proteins suggests that this family may be functionally analogous to .

[ "GO:0009297", "GO:0019867" ]

[ "pilus assembly", "outer membrane" ]

[ "biological_process", "cellular_component" ]

2

[ "PFAM" ]

[ "PF07655" ]

[ "Secretin_N_2" ]

[ 2882 ]

1

[]

0

[ "9u5s" ]

1

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Plasmid R64", "metagenomes" ]

[ 2825, 9, 1, 47 ]

4

[]

0

true

Domain

Secretin, N-terminal

Secretin_N_2

9

IPR011515

11,515

Shugoshin, C-terminal

Shugoshin_C

Domain

4,334

false

This entry represents the C-terminal domain of Shugoshin (Sgo1) kinetochore-attachment proteins. Shugoshin has a conserved coiled-coil N-terminal domain and a highly conserved C-terminal basic region ( ). Shugoshin is a crucial target of Bub1 kinase that plays a central role in chromosome cohesion during mitosis and me...

[ "GO:0045132", "GO:0000775", "GO:0005634" ]

[ "meiotic chromosome segregation", "chromosome, centromeric region", "nucleus" ]

[ "biological_process", "cellular_component", "cellular_component" ]

3

[ "PFAM" ]

[ "PF07557" ]

[ "Shugoshin_C" ]

[ 4334 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-141444", "R-HSA-2467813", "R-HSA-2500257", "R-HSA-5663220", "R-HSA-68877", "R-HSA-69273", "R-HSA-9648025", "R-MMU-141444", "R-MMU-2467813", "R-MMU-2500257", "R-MMU-5663220", "R-MMU-68877", "R-MMU-69273", "R-MMU-9648025" ]

[ "REACTOME:R-HSA-141444", "REACTOME:R-HSA-2467813", "REACTOME:R-HSA-2500257", "REACTOME:R-HSA-5663220", "REACTOME:R-HSA-68877", "REACTOME:R-HSA-69273", "REACTOME:R-HSA-9648025", "REACTOME:R-MMU-141444", "REACTOME:R-MMU-2467813", "REACTOME:R-MMU-2500257", "REACTOME:R-MMU-5663220", "REACTOME:R-MM...

14

[]

0

[ "PUB00014798", "PUB00044772", "PUB00044773", "PUB00044774" ]

[ "14730319", "18987869", "16687935", "17322402" ]

[ "The conserved kinetochore protein shugoshin protects centromeric cohesion during meiosis.", "Shugoshin regulates cohesion by driving relocalization of PP2A in Xenopus extracts.", "Human Shugoshin mediates kinetochore-driven formation of kinetochore microtubules.", "Shugoshin enables tension-generating attach...

[ 2004, 2008, 2006, 2007 ]

4

[]

0

null

[ "Eukaryota" ]

[ 4334 ]

1

[ "Arabidopsis thaliana", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "...

[ 9, 3, 2, 2, 1, 1, 6, 2, 1, 2, 15 ]

11

true

Domain

Shugoshin, C-terminal

Shugoshin_C

7

IPR011516

11,516

Shugoshin, N-terminal coiled-coil domain

Shugoshin_N

Domain

1,406

false

This entry represents the N-terminal domain of Shugoshin (Sgo1) kinetochore-attachment proteins. Shugoshin has this conserved coiled-coil N-terminal domain and a highly conserved C-terminal basic region ( ). Shugoshin is a crucial target of Bub1 kinase that plays a central role in chromosome cohesion during mitosis and...

[]

0

[ "PFAM" ]

[ "PF07558" ]

[ "Shugoshin_N" ]

[ 1406 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-141444", "R-HSA-2467813", "R-HSA-2500257", "R-HSA-5663220", "R-HSA-68877", "R-HSA-69273", "R-HSA-9648025", "R-MMU-141444", "R-MMU-2467813", "R-MMU-2500257", "R-MMU-5663220", "R-MMU-68877", "R-MMU-69273", "R-MMU-9648025" ]

[ "REACTOME:R-HSA-141444", "REACTOME:R-HSA-2467813", "REACTOME:R-HSA-2500257", "REACTOME:R-HSA-5663220", "REACTOME:R-HSA-68877", "REACTOME:R-HSA-69273", "REACTOME:R-HSA-9648025", "REACTOME:R-MMU-141444", "REACTOME:R-MMU-2467813", "REACTOME:R-MMU-2500257", "REACTOME:R-MMU-5663220", "REACTOME:R-MM...

14

[]

0

[ "PUB00014798", "PUB00044772", "PUB00044773", "PUB00044774" ]

[ "14730319", "18987869", "16687935", "17322402" ]

[ "The conserved kinetochore protein shugoshin protects centromeric cohesion during meiosis.", "Shugoshin regulates cohesion by driving relocalization of PP2A in Xenopus extracts.", "Human Shugoshin mediates kinetochore-driven formation of kinetochore microtubules.", "Shugoshin enables tension-generating attach...

[ 2004, 2008, 2006, 2007 ]

4

[]

0

null

[ "Eukaryota" ]

[ 1406 ]

1

[ "Caenorhabditis elegans", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 2484...

[ 1, 10, 3, 1, 1, 1, 1, 2 ]

8

true

Domain

Shugoshin, N-terminal coiled-coil domain

Shugoshin_N

2

IPR011517

11,517

RNA polymerase sigma-70 ECF-like

RNA_pol_sigma70_ECF-like

Family

2,550

false

This entry represents a group of sigma factors that are able to regulate extra cellular function (ECF) [ ]. Eubacteria display considerable genetic diversity between ECF-sigma factors, but all retain two features: the ability to respond to extra-cytoplasmic functions; and regulation by anti-sigma and anti-anti-sigma fa...

[]

0

[ "NCBIFAM" ]

[ "TIGR02999" ]

[ "Sig-70_X6" ]

[ 2550 ]

1

[]

0

[]

0

[ "PUB00000061", "PUB00002181", "PUB00004340", "PUB00014743", "PUB00016691", "PUB00088319" ]

[ "3052291", "1597408", "3092189", "12073657", "15374527", "25596450" ]

[ "Structure and function of bacterial sigma factors.", "The sigma 70 family: sequence conservation and evolutionary relationships.", "Sigma factors from E. coli, B. subtilis, phage SP01, and phage T4 are homologous proteins.", "The extracytoplasmic function (ECF) sigma factors.", "The extracytoplasmic functi...

[ 1988, 1992, 1986, 2002, 2004, 2015 ]

6

[ "IPR039425" ]

[]

1

0

1

[ "Bacteria", "Eukaryota", "unclassified sequences", "uncultured marine thaumarchaeote AD1000_01_F04" ]

[ 2523, 9, 17, 1 ]

4

[]

0

true

Family

RNA polymerase sigma-70 ECF-like

RNA_pol_sigma70_ECF-like

8

IPR011518

11,518

Transposase, Rhodopirellula-type

Transposase_36

Family

2,214

false

These transposases are found in the planctomycete Rhodopirellula baltica, the cyanobacterium Nostoc, and the Gram-positive bacterium Streptomyces.

[]

0

[ "PFAM" ]

[ "PF07592" ]

[ "DDE_Tnp_ISAZ013" ]

[ 2214 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria", "metagenomes" ]

[ 117, 1769, 328 ]

3

[]

0

true

Family

Transposase, Rhodopirellula-type

Transposase_36

3

IPR011519

11,519

ASPIC/UnbV

UnbV_ASPIC

Domain

10,743

false

This conserved domain is found associated with in many bacterial proteins. It is also found associated with in several eukaryotic integrin-like proteins (e.g. human ASPIC ) and in several other bacterial proteins [ ]. ASPIC, also known as cartilage acidic protein-1 (CRTAC1), is a secreted glycoprotein with roles in dev...

[]

0

[ "PFAM" ]

[ "PF07593" ]

[ "UnbV_ASPIC" ]

[ 10743 ]

1

[]

0

[ "9etn" ]

1

[ "PUB00014744", "PUB00162466" ]

[ "12536216", "39029889" ]

[ "A genomics-guided approach for discovering and expressing cryptic metabolic pathways.", "CRTAC1 has a Compact β-propeller-TTR Core Stabilized by Potassium Ions." ]

[ 2003, 2024 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "Methanobacteriota", "unclassified sequences" ]

[ 8437, 1923, 126, 257 ]

4

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 14, 3, 2, 5 ]

4

true

Domain

ASPIC/UnbV

UnbV_ASPIC

6

IPR011520

11,520

Vestigial family

Vg_fam

Family

3,568

false

The mammalian TEF and the Drosophila scalloped genes belong to a conserved family of transcriptional factors that possesses a TEA/ATTS DNA-binding domain. Transcriptional activation by these proteins likely requires interactions with specific coactivators. In Drosophila, Vestigial (Vg) has a short 25 aa motif necessary...

[ "GO:0006355", "GO:0005634" ]

[ "regulation of DNA-templated transcription", "nucleus" ]

[ "biological_process", "cellular_component" ]

2

[ "PFAM", "PANTHER" ]

[ "PF07545", "PTHR15950" ]

[ "Vg_Tdu", "" ]

[ 3493, 3510 ]

2

[]

0

[ "5z2q", "6y20" ]

2

[ "PUB00007975", "PUB00067650", "PUB00100081", "PUB00100082" ]

[ "10518497", "15140898", "12376544", "22632831" ]

[ "TONDU (TDU), a novel human protein related to the product of vestigial (vg) gene of Drosophila melanogaster interacts with vertebrate TEF factors and substitutes for Vg function in wing formation.", "Vgl-4, a novel member of the vestigial-like family of transcription cofactors, regulates alpha1-adrenergic activa...

[ 1999, 2004, 2002, 2012 ]

4

[]

0

null

[ "Eumetazoa" ]

[ 3568 ]

1

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 9, 2, 5, 10, 4 ]

5

true

Family

Vestigial family

Vg_fam

5

IPR011521

11,521

YTV

Repeat

423

false

This entry represents several repeats of a sequence whose core contains the residues YTV which are found in hypothetical proteins from Planctomycetes.

[]

0

[ "PFAM" ]

[ "PF07639" ]

[ "YTV" ]

[ 423 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Methanosarcina vacuolata Z-761", "ecological metagenomes" ]

[ 415, 3, 1, 4 ]

4

[]

0

true

Repeat

YTV

3

IPR011522

11,522

Thiamin/hydroxymethyl pyrimidine-binding YkoF, putative

Thiamin/HMP-bd_put_YkoF

Domain

1,154

false

This entry represents YkoF-related proteins. YkoF is involved in the hydroxymethyl pyrimidine (HMP) salvage pathway [ ]. The domain is found in pairs in these proteins.

[]

0

[ "PFAM" ]

[ "PF07615" ]

[ "Ykof" ]

[ 1154 ]

1

[]

0

[ "1s7h", "1s99", "1sbr" ]

3

[ "PUB00027817" ]

[ "15451668" ]

[ "The structure and ligand binding properties of the B. subtilis YkoF gene product, a member of a novel family of thiamin/HMP-binding proteins." ]

[ 2004 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "ecological metagenomes" ]

[ 1134, 15, 5 ]

3

[]

0

true

Domain

Thiamin/hydroxymethyl pyrimidine-binding YkoF, putative

Thiamin/HMP-bd_put_YkoF

7

IPR011524

11,524

SARAH domain

SARAH_dom

Domain

11,093

false

The SARAH (Sav/Rassf/Hpo) domain is found at the C terminus in three classes of eukaryotic tumour suppressors that give the domain its name. In the Sav (Salvador) and Hpo (Hippo) families, the SARAH domain mediates signal transduction from Hpo via the Sav scaffolding protein to the downstream component Wts (Warts); the...

[ "GO:0007165" ]

[ "signal transduction" ]

[ "biological_process" ]

1

[ "PFAM", "PROFILE" ]

[ "PF16517", "PS50951" ]

[ "Nore1-SARAH", "SARAH" ]

[ 6432, 10985 ]

2

[ "PROSITEDOC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "PDOC50951", "R-BTA-2028269", "R-CEL-2028269", "R-DME-2028269", "R-DME-390089", "R-DME-390098", "R-DME-390150", "R-DME-451806", "R-DRE-2028269", "R-HSA-2028269", "R-MMU-2028269", "R-RNO-2028269", "R-XTR-2028269" ]

[ "PROSITEDOC:PDOC50951", "REACTOME:R-BTA-2028269", "REACTOME:R-CEL-2028269", "REACTOME:R-DME-2028269", "REACTOME:R-DME-390089", "REACTOME:R-DME-390098", "REACTOME:R-DME-390150", "REACTOME:R-DME-451806", "REACTOME:R-DRE-2028269", "REACTOME:R-HSA-2028269", "REACTOME:R-MMU-2028269", "REACTOME:R-RN...

13

[ "2jo8", "2ymy", "3wws", "4hkd", "4l0n", "4lgd", "4nr2", "4oh8", "4oh9", "5xcq", "5xcr", "5xcs", "5xct", "5xcu", "5xcv", "5xcx", "6ao5", "6bn1", "6lcs", "6lz4", "7cea", "7ceb", "7cec", "7dkj", "7km6", "7nwl", "7x91", "8hyl", "8iqp", "8iqq", "8iqr", "8iqs"...

37

[ "PUB00014752", "PUB00097384" ]

[ "14654011", "29519817" ]

[ "A novel interaction motif, SARAH, connects three classes of tumor suppressor.", "Salvador has an extended SARAH domain that mediates binding to Hippo kinase." ]

[ 2003, 2018 ]

2

[]

[ "IPR024205", "IPR049787" ]

0

2

0

[ "Eukaryota", "Pedosphaera parvula (strain Ellin514)", "Saccharolobus islandicus", "anaerobic digester metagenome" ]

[ 11081, 1, 10, 1 ]

4

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 3, 26, 6, 26, 16, 32 ]

6

true

Domain

SARAH domain

SARAH_dom

8

IPR011527

11,527

ABC transporter type 1, transmembrane domain

ABC1_TM_dom

Domain

437,543

false

This entry represents the transmembrane domain in cases where the TMD and ABC region are found in the same protein, and corresponds to ABC type 1 from Transporter Classification Database . ABC transporters minimally contain two conserved regions: a highly conserved ATP binding cassette (ABC) and a less conserved transm...

[ "GO:0005524", "GO:0140359", "GO:0055085", "GO:0016020" ]

[ "ATP binding", "ABC-type transporter activity", "transmembrane transport", "membrane" ]

[ "molecular_function", "molecular_function", "biological_process", "cellular_component" ]

4

[ "PFAM", "PFAM", "PFAM", "PROFILE" ]

[ "PF00664", "PF06472", "PF13748", "PS50929" ]

[ "ABC_membrane", "ABC_membrane_2", "ABC_membrane_3", "ABC_TM1F" ]

[ 390869, 21182, 685, 431972 ]

4

[ "PROSITEDOC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACT...

[ "PDOC00364", "R-BTA-1660661", "R-BTA-189483", "R-BTA-2142691", "R-BTA-382556", "R-BTA-9707564", "R-BTA-9753281", "R-BTA-9758890", "R-CEL-1369007", "R-CEL-159418", "R-CEL-189483", "R-CEL-2142845", "R-CEL-382556", "R-CEL-9748787", "R-CEL-9749641", "R-CEL-9753281", "R-CEL-9754706", "R...

[ "PROSITEDOC:PDOC00364", "REACTOME:R-BTA-1660661", "REACTOME:R-BTA-189483", "REACTOME:R-BTA-2142691", "REACTOME:R-BTA-382556", "REACTOME:R-BTA-9707564", "REACTOME:R-BTA-9753281", "REACTOME:R-BTA-9758890", "REACTOME:R-CEL-1369007", "REACTOME:R-CEL-159418", "REACTOME:R-CEL-189483", "REACTOME:R-CE...

232

[ "2hyd", "2onj", "3b5w", "3b5x", "3b5y", "3b5z", "3b60", "3g5u", "3g60", "3g61", "3qf4", "3wme", "3wmf", "3wmg", "3zdq", "4a82", "4ayt", "4ayw", "4ayx", "4f4c", "4ksb", "4ksc", "4ksd", "4lsg", "4m1m", "4m2s", "4m2t", "4mrn", "4mrp", "4mrr", "4mrs", "4mrv"...

568

[ "PUB00014769", "PUB00014770", "PUB00017894", "PUB00043654" ]

[ "9873074", "10529352", "11421269", "11421270" ]

[ "Getting in or out: early segregation between importers and exporters in the evolution of ATP-binding cassette (ABC) transporters.", "ABC-ATPases, adaptable energy generators fuelling transmembrane movement of a variety of molecules in organisms from bacteria to humans.", "ABC transporters: physiology, structur...

[ 1999, 1999, 2001, 2001 ]

4

[]

[ "IPR030240", "IPR030254", "IPR044726", "IPR044746", "IPR047083", "IPR047957" ]

0

6

0

[ "Archaea", "Bacteria", "Eukaryota", "Plasmid pAD1", "Viruses", "unclassified sequences" ]

[ 1580, 270453, 162774, 1, 16, 2719 ]

6

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus",...

[ 258, 58, 133, 177, 7, 245, 93, 22, 199, 154, 12, 9, 386 ]

13

true

Domain

ABC transporter type 1, transmembrane domain

ABC1_TM_dom

6

IPR011528

11,528

Nuclease-related domain, NERD

NERD

Domain

17,655

false

The nuclease-related domain (NERD) is found in a broad range of bacterial, as well as single archaeal and plant proteins. Most NERD-containing proteins have a single domain, sometimes with additional (predicted) transmembrane helices. In a few instances, proteins containing NERD domains have additional domains (mostly ...

[]

0

[ "PFAM", "PROFILE" ]

[ "PF08378", "PS50965" ]

[ "NERD", "NERD" ]

[ 17270, 11476 ]

2

[ "PROSITEDOC" ]

[ "PDOC50965" ]

[ "PROSITEDOC:PDOC50965" ]

1

[ "2mfq" ]

1

[ "PUB00014771" ]

[ "15055202" ]

[ "NERD: a DNA processing-related domain present in the anthrax virulence plasmid, pXO1." ]

[ 2004 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 171, 16329, 966, 8, 181 ]

5

[ "Arabidopsis thaliana", "Danio rerio", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 6, 2, 3, 4 ]

4

true

Domain

Nuclease-related domain, NERD

NERD

2

IPR011529

11,529

Glutamate 5-kinase

Glu_5kinase

Family

24,190

false

L-glutamate 5-phosphotransferase, (gamma-glutamyl kinase, proB, ), catalyzes the first step in proline biosynthesis ATP + L-glutamate = ADP + L-glutamate 5-phosphate. the product of which rapidly cyclizes to 5-oxoproline and phosphate.

[ "GO:0004349", "GO:0055129", "GO:0005737" ]

[ "glutamate 5-kinase activity", "L-proline biosynthetic process", "cytoplasm" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PIRSF" ]

[ "PIRSF000729" ]

[ "GK" ]

[ 24190 ]

1

[ "EC", "METACYC" ]

[ "2.7.2.11", "PWY-6922" ]

[ "EC:2.7.2.11", "METACYC:PWY-6922" ]

2

[ "2ako", "2j5t", "2j5v", "2w21", "4q1t", "8zpj", "8zpr", "8zri" ]

8

[]

0

[ "IPR005715" ]

[]

1

0

1

[ "Archaea", "Bacteria", "Eukaryota", "Hyperionvirus sp.", "unclassified sequences" ]

[ 273, 21820, 1669, 1, 427 ]

5

[ "Escherichia coli (strain K12)", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)", "Zea mays" ]

[ 1, 1, 2, 1, 2 ]

5

true

Family

Glutamate 5-kinase

Glu_5kinase

7

IPR011530

11,530

Ribosomal RNA adenine dimethylase

rRNA_adenine_dimethylase

Family

33,199

false

The bacterial enzyme KsgA catalyses the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases in 16S rRNA. This enzyme and the resulting modified adenosine bases appear to be conserved in all species of eubacteria, eukaryotes, and archaea, and in eukaryotic or...

[ "GO:0000179", "GO:0006364" ]

[ "rRNA (adenine-N6,N6-)-dimethyltransferase activity", "rRNA processing" ]

[ "molecular_function", "biological_process" ]

2

[ "HAMAP", "NCBIFAM" ]

[ "MF_00607", "TIGR00755" ]

[ "16SrRNA_methyltr_A", "ksgA" ]

[ 27478, 33097 ]

2

[ "EC", "EC", "GP", "REACTOME", "REACTOME", "REACTOME" ]

[ "2.1.1", "2.1.1.182", "GenProp0802", "R-HSA-2151201", "R-HSA-6790901", "R-HSA-6793080" ]

[ "EC:2.1.1", "EC:2.1.1.182", "GP:GenProp0802", "REACTOME:R-HSA-2151201", "REACTOME:R-HSA-6790901", "REACTOME:R-HSA-6793080" ]

6

[ "1qyr", "1zq9", "2h1r", "3ftc", "3ftd", "3fte", "3ftf", "3fut", "3fuu", "3fuv", "3fuw", "3fux", "3fyc", "3fyd", "3grr", "3gru", "3grv", "3gry", "3r9x", "3tpz", "3tqs", "3uzu", "4adv", "4gc5", "4gc9", "4jxj", "6aax", "6ajk", "6ifs", "6ift", "6ifv", "6ifw"...

82

[ "PUB00014820", "PUB00072555", "PUB00101503", "PUB00101504", "PUB00101505" ]

[ "15136037", "23804760", "4336392", "4329247", "6575236" ]

[ "Crystal structure of KsgA, a universally conserved rRNA adenine dimethyltransferase in Escherichia coli.", "Structural basis for S-adenosylmethionine binding and methyltransferase activity by mitochondrial transcription factor B1.", "Mechanism of kasugamycin resistance in Escherichia coli.", "Change in methy...

[ 2004, 2013, 1972, 1971, 1983 ]

5

[ "IPR001737" ]

[]

1

0

1

[ "Archaea", "Bacteria", "Eukaryota", "unclassified Caudoviricetes", "unclassified sequences" ]

[ 788, 25261, 6633, 2, 515 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus",...

[ 12, 2, 6, 2, 1, 10, 3, 1, 5, 6, 1, 1, 10 ]

13

true

Family

Ribosomal RNA adenine dimethylase

rRNA_adenine_dimethylase

2

IPR011531

11,531

Bicarbonate transporter-like, transmembrane domain

HCO3_transpt-like_TM_dom

Domain

32,990

false

Bicarbonate (HCO 3 - ) transport mechanisms are the principal regulators of pH in animal cells. Such transport also plays a vital role in acid-base movements in the stomach, pancreas, intestine, kidney, reproductive organs and the central nervous system. Functional studies have suggested four different HCO 3 - transpor...

[ "GO:0006820", "GO:0016020" ]

[ "monoatomic anion transport", "membrane" ]

[ "biological_process", "cellular_component" ]

2

[ "PFAM" ]

[ "PF00955" ]

[ "HCO3_cotransp" ]

[ 32990 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-425381", "R-HSA-1237044", "R-HSA-1247673", "R-HSA-425381", "R-HSA-5619050", "R-HSA-5619054", "R-HSA-9013405", "R-HSA-9013406", "R-HSA-9013407", "R-HSA-9013409", "R-HSA-9035034", "R-HSA-9925563", "R-MMU-1237044", "R-MMU-1247673", "R-MMU-425381", "R-MMU-9013405", "R-MMU-9013406"...

[ "REACTOME:R-BTA-425381", "REACTOME:R-HSA-1237044", "REACTOME:R-HSA-1247673", "REACTOME:R-HSA-425381", "REACTOME:R-HSA-5619050", "REACTOME:R-HSA-5619054", "REACTOME:R-HSA-9013405", "REACTOME:R-HSA-9013406", "REACTOME:R-HSA-9013407", "REACTOME:R-HSA-9013409", "REACTOME:R-HSA-9035034", "REACTOME:...

26

[ "1bh7", "1bnx", "1bzk", "4yzf", "5l25", "5sv9", "6caa", "7rtm", "7tvz", "7tw0", "7tw1", "7tw2", "7tw3", "7tw5", "7tw6", "7ty4", "7ty6", "7ty7", "7ty8", "7tya", "7uz3", "7uzu", "7uzv", "7v07", "7v0k", "7v0m", "7v0t", "7v0u", "7v0y", "7v19", "7x1g", "7x1h"...

74

[ "PUB00005997", "PUB00006023", "PUB00018713", "PUB00028060", "PUB00099836", "PUB00099837", "PUB00099847", "PUB00099848", "PUB00099849", "PUB00099850", "PUB00099852", "PUB00099858" ]

[ "2289848", "9235899", "9261985", "12447444", "17459946", "24121512", "27601653", "26542571", "27717063", "29438259", "29500354", "27449211" ]

[ "Molecular biology of the anion exchanger gene family.", "Cloning and functional expression of a human kidney Na+:HCO3- cotransporter.", "The electrogenic Na/HCO3 cotransporter.", "Arabidopsis boron transporter for xylem loading.", "Transport and regulatory characteristics of the yeast bicarbonate transport...

[ 1990, 1997, 1997, 2002, 2007, 2013, 2016, 2015, 2017, 2018, 2018, 2016 ]

12

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 47, 32940, 3 ]

3

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 33, 14, 138, 22, 56, 75, 2, 15, 71, 1, 1, 60 ]

12

true

Domain

Bicarbonate transporter-like, transmembrane domain

HCO3_transpt-like_TM_dom

6

IPR011532

11,532

Sec-independent protein translocase TatC, archaeal

TatC_arc

Family

50

false

This entry represents the TatC translocase component of the Sec-independent protein translocation system in archaeal species. This system is responsible for translocation of folded proteins, often with bound cofactors across the periplasmic membrane [ ].

[]

0

[ "NCBIFAM" ]

[ "TIGR01912" ]

[ "TatC-Arch" ]

[ 50 ]

1

[ "GP" ]

[ "GenProp0127" ]

[ "GP:GenProp0127" ]

1

[]

0

[ "PUB00013758" ]

[ "12634324" ]

[ "Moving folded proteins across the bacterial cell membrane." ]

[ 2003 ]

1

[ "IPR002033" ]

[]

1

0

1

[ "Archaea", "Tropheryma whipplei (strain Twist)" ]

[ 49, 1 ]

2

[]

0

true

Family

Sec-independent protein translocase TatC, archaeal

TatC_arc

5

IPR011534

11,534

Aspartate-semialdehyde dehydrogenase, gamma-type

Asp_ADH_gamma-type

Family

5,926

false

Bacteria, plants and fungi metabolise aspartic acid to produce four amino acids -lysine, threonine, methionine and isoleucine -in a series of reactions known as the aspartate pathway. Additionally, several important metabolic intermediates are produced by these reactions, such as diaminopimelic acid, an essential compo...

[ "GO:0004073", "GO:0050661", "GO:0009088", "GO:0009089", "GO:0009097" ]

[ "aspartate-semialdehyde dehydrogenase activity", "NADP binding", "L-threonine biosynthetic process", "L-lysine biosynthetic process via diaminopimelate", "isoleucine biosynthetic process" ]

[ "molecular_function", "molecular_function", "biological_process", "biological_process", "biological_process" ]

5

[ "NCBIFAM" ]

[ "TIGR01745" ]

[ "asd_gamma" ]

[ 5926 ]

1

[ "EC", "GP", "GP", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC" ]

[ "1.2.1.11", "GenProp0160", "GenProp1553", "PWY-2941", "PWY-2942", "PWY-5097", "PWY-6160", "PWY-6559", "PWY-6562", "PWY-7153", "PWY-7977", "PWY-8088", "PWY-8179", "PWY-8296" ]

[ "EC:1.2.1.11", "GP:GenProp0160", "GP:GenProp1553", "METACYC:PWY-2941", "METACYC:PWY-2942", "METACYC:PWY-5097", "METACYC:PWY-6160", "METACYC:PWY-6559", "METACYC:PWY-6562", "METACYC:PWY-7153", "METACYC:PWY-7977", "METACYC:PWY-8088", "METACYC:PWY-8179", "METACYC:PWY-8296" ]

14

[ "1brm", "1gl3", "1mb4", "1mc4", "1nwc", "1nwh", "1nx6", "1oza", "1pqp", "1pqu", "1pr3", "1ps8", "1pu2", "1q2x", "1t4b", "1t4d", "1ta4", "1tb4", "3pzr", "3q0e", "3uw3", "4r5m", "4woj", "5bnt", "6bac", "7skb", "7tcm" ]

27

[ "PUB00029242", "PUB00029661", "PUB00034672", "PUB00034673", "PUB00034674", "PUB00034675" ]

[ "14559965", "15272161", "11352712", "1673060", "15388927", "16225889" ]

[ "Capture of an intermediate in the catalytic cycle of L-aspartate-beta-semialdehyde dehydrogenase.", "The role of substrate-binding groups in the mechanism of aspartate-beta-semialdehyde dehydrogenase.", "The central enzymes of the aspartate family of amino acid biosynthesis.", "Chemical and kinetic mechanism...

[ 2003, 2004, 2001, 1991, 2004, 2005 ]

6

[ "IPR012080" ]

[]

1

0

1

[ "Bacteria", "Candidatus Iainarchaeum sp.", "Eukaryota", "unclassified sequences" ]

[ 5872, 1, 13, 40 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Aspartate-semialdehyde dehydrogenase, gamma-type

Asp_ADH_gamma-type

4

IPR011536

11,536

Ferredoxin 2Fe-2S type, proteobacteria

Fdx_isc

Family

4,634

false

At least three types of Fe-S cluster-biosynthesis systems are known: NIF, ISC and SUF [ ]. This family consists of proteobacterial ferredoxins associated with and essential to the ISC (iron-sulfur cluster) system of 2Fe-2S cluster assembly [ ]. This family is closely related to (but excludes) eukaryotic (mitochondrial)...

[ "GO:0009055", "GO:0051537" ]

[ "electron transfer activity", "2 iron, 2 sulfur cluster binding" ]

[ "molecular_function", "molecular_function" ]

2

[ "NCBIFAM" ]

[ "TIGR02007" ]

[ "fdx_isc" ]

[ 4634 ]

1

[ "GP" ]

[ "GenProp0138" ]

[ "GP:GenProp0138" ]

1

[ "1i7h", "3ah7" ]

2

[ "PUB00028656", "PUB00068839" ]

[ "11551196", "15952888" ]

[ "Crystal structure of Escherichia coli Fdx, an adrenodoxin-type ferredoxin involved in the assembly of iron-sulfur clusters.", "Structure, function, and formation of biological iron-sulfur clusters." ]

[ 2001, 2005 ]

2

[ "IPR001055" ]

[]

1

0

1

[ "Bacteria", "Opisthokonta", "unclassified sequences" ]

[ 4573, 5, 56 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Ferredoxin 2Fe-2S type, proteobacteria

Fdx_isc

7

IPR011537

11,537

NADH ubiquinone oxidoreductase, F subunit

NADH-UbQ_OxRdtase_suF

Family

17,080

false

This entry describes the F subunit of complexes that resemble NADH-quinone oxidoreductases. The electron acceptor is a quinone, ubiquinone, in mitochondria and most bacteria, including Escherichia coli, where the recommended gene symbol is nuoF. This family does not have any members in chloroplast or cyanobacteria, whe...

[ "GO:0010181", "GO:0051287", "GO:0051539" ]

[ "FMN binding", "NAD binding", "4 iron, 4 sulfur cluster binding" ]

[ "molecular_function", "molecular_function", "molecular_function" ]

3

[ "NCBIFAM" ]

[ "TIGR01959" ]

[ "nuoF_fam" ]

[ 17080 ]

1

[ "EC", "GP", "GP", "GP", "GP", "GP", "GP", "GP", "GP", "GP", "GP", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "7.1.1.-", "GenProp0135", "GenProp1198", "GenProp1230", "GenProp1254", "GenProp1341", "GenProp1537", "GenProp1583", "GenProp1608", "GenProp1637", "GenProp1751", "R-DDI-6799198", "R-DDI-9837999", "R-HSA-611105", "R-HSA-6799198", "R-HSA-9837999", "R-MMU-611105", "R-MMU-6799198", "R...

[ "EC:7.1.1.-", "GP:GenProp0135", "GP:GenProp1198", "GP:GenProp1230", "GP:GenProp1254", "GP:GenProp1341", "GP:GenProp1537", "GP:GenProp1583", "GP:GenProp1608", "GP:GenProp1637", "GP:GenProp1751", "REACTOME:R-DDI-6799198", "REACTOME:R-DDI-9837999", "REACTOME:R-HSA-611105", "REACTOME:R-HSA-6...

19

[ "2fug", "2ybb", "3i9v", "3iam", "3ias", "3m9s", "4hea", "5gpn", "5gup", "5lc5", "5ldw", "5ldx", "5lnk", "5o31", "5xtb", "5xtd", "5xth", "5xti", "6g2j", "6g72", "6gcs", "6i0d", "6i1p", "6q8o", "6q8w", "6q8x", "6q9d", "6qa9", "6qbx", "6qc2", "6qc3", "6qc4"...

313

[ "PUB00005074", "PUB00043561", "PUB00045437" ]

[ "1470679", "10940377", "18394423" ]

[ "The NADH:ubiquinone oxidoreductase (complex I) of respiratory chains.", "The respiratory complex I of bacteria, archaea and eukarya and its module common with membrane-bound multisubunit hydrogenases.", "Assembly of the Escherichia coli NADH:ubiquinone oxidoreductase (complex I)." ]

[ 1992, 2000, 2008 ]

3

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 12720, 4136, 224 ]

3

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus",...

[ 2, 1, 1, 4, 1, 4, 3, 1, 3, 2, 8 ]

11

true

Family

NADH ubiquinone oxidoreductase, F subunit

NADH-UbQ_OxRdtase_suF

5

IPR011538

11,538

NADH-ubiquinone oxidoreductase 51kDa subunit, FMN-binding domain

Nuo51_FMN-bd

Domain

42,289

false

This entry represents the FMN-binding domain of NADH-ubiquinone oxidoreductase 51kDa subunit from NADH:ubiquinone oxidoreductase. Among the many polypeptide subunits that make up complex I, there is one with a molecular weight of 51kDa (in mammals), which is the second largest subunit of complex I [ ]. The 51kDa subuni...

[]

0

[ "PFAM" ]

[ "PF01512" ]

[ "Complex1_51K" ]

[ 42289 ]

1

[ "GP", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "GenProp0135", "R-DDI-6799198", "R-DDI-9837999", "R-HSA-611105", "R-HSA-6799198", "R-HSA-9837999", "R-MMU-611105", "R-MMU-6799198", "R-MMU-9837999", "R-SPO-9837999" ]

[ "GP:GenProp0135", "REACTOME:R-DDI-6799198", "REACTOME:R-DDI-9837999", "REACTOME:R-HSA-611105", "REACTOME:R-HSA-6799198", "REACTOME:R-HSA-9837999", "REACTOME:R-MMU-611105", "REACTOME:R-MMU-6799198", "REACTOME:R-MMU-9837999", "REACTOME:R-SPO-9837999" ]

10

[ "2fug", "2ybb", "3i9v", "3iam", "3ias", "3m9s", "4hea", "5gpn", "5gup", "5lc5", "5ldw", "5ldx", "5lnk", "5o31", "5xf9", "5xfa", "5xtb", "5xtd", "5xth", "5xti", "6g2j", "6g72", "6gcs", "6hl2", "6hl3", "6hl4", "6hla", "6hli", "6hlj", "6hlm", "6i0d", "6i1p"...

389

[ "PUB00001392", "PUB00005074", "PUB00040815", "PUB00043561", "PUB00045437", "PUB00071848" ]

[ "2029890", "1470679", "16469879", "10940377", "18394423", "12600193" ]

[ "The respiratory-chain NADH dehydrogenase (complex I) of mitochondria.", "The NADH:ubiquinone oxidoreductase (complex I) of respiratory chains.", "Structure of the hydrophilic domain of respiratory complex I from Thermus thermophilus.", "The respiratory complex I of bacteria, archaea and eukarya and its modul...

[ 1991, 1992, 2006, 2000, 2008, 2003 ]

6

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 358, 35959, 4954, 1018 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus",...

[ 2, 1, 1, 8, 2, 13, 7, 1, 5, 4, 1, 10 ]

12

true

Domain

NADH-ubiquinone oxidoreductase 51kDa subunit, FMN-binding domain

Nuo51_FMN-bd

5

IPR011539

11,539

Rel homology domain, DNA-binding domain

RHD_DNA_bind_dom

Domain

16,269

false

The Rel homology domain (RHD) is found in a family of eukaryotic transcription factors, which includes NF-kappaB, Dorsal, Relish, NFAT, among others. The RHD is composed of two structural domains that grip the DNA in the major groove: the N-terminal DNA binding domain and the C-terminal domain, which has an immunoglobu...

[ "GO:0003677", "GO:0003700", "GO:0006355" ]

[ "DNA binding", "DNA-binding transcription factor activity", "regulation of DNA-templated transcription" ]

[ "molecular_function", "molecular_function", "biological_process" ]

3

[ "PFAM", "PROFILE" ]

[ "PF00554", "PS50254" ]

[ "RHD_DNA_bind", "REL_2" ]

[ 15680, 16224 ]

2

[ "PROSITEDOC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACT...

[ "PDOC00924", "R-CFA-1169091", "R-CFA-1810476", "R-CFA-193692", "R-CFA-202424", "R-CFA-209560", "R-CFA-2871837", "R-CFA-3134963", "R-CFA-3214841", "R-CFA-445989", "R-CFA-448706", "R-CFA-5607764", "R-CFA-5621575", "R-CFA-5684264", "R-CFA-6798695", "R-CFA-9020702", "R-CFA-933542", "R-...

[ "PROSITEDOC:PDOC00924", "REACTOME:R-CFA-1169091", "REACTOME:R-CFA-1810476", "REACTOME:R-CFA-193692", "REACTOME:R-CFA-202424", "REACTOME:R-CFA-209560", "REACTOME:R-CFA-2871837", "REACTOME:R-CFA-3134963", "REACTOME:R-CFA-3214841", "REACTOME:R-CFA-445989", "REACTOME:R-CFA-448706", "REACTOME:R-CFA...

124

[ "1a02", "1a3q", "1a66", "1bvo", "1gji", "1ikn", "1imh", "1le5", "1le9", "1lei", "1nfa", "1nfi", "1nfk", "1ooa", "1owr", "1p7h", "1pzu", "1ram", "1s9k", "1svc", "1vkx", "2as5", "2i9t", "2o61", "2o93", "2ram", "2v2t", "3do7", "3gut", "3qrf", "5u01", "5zmc"...

48

[ "PUB00004201", "PUB00016328", "PUB00016329", "PUB00049544" ]

[ "7830764", "9794820", "15516339", "17869269" ]

[ "Structure of the NF-kappa B p50 homodimer bound to DNA.", "Combinatorial transcription factors.", "cis-acting, element-specific transcriptional activity of differentially phosphorylated nuclear factor-kappa B.", "X-ray structure of a NF-kappaB p50/RelB/DNA complex reveals assembly of multiple dimers on tande...

[ 1995, 1998, 2005, 2007 ]

4

[]

[ "IPR015646", "IPR030495", "IPR030496", "IPR030497", "IPR030503", "IPR042845" ]

0

6

0

[ "Bacteria", "Eukaryota", "Methanofollis fontis", "Viruses" ]

[ 36, 16228, 1, 4 ]

4

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 68, 16, 62, 73, 54 ]

5

true

Domain

Rel homology domain, DNA-binding domain

RHD_DNA_bind_dom

7

IPR011540

11,540

AbgT, Proteobacteria

AbgT_Proteobac

Family

353

false

AbgT catalyzes the concentration-dependent uptake of p-aminobenzoyl-glutamate (PABA-GLU) into cells. This allows accumulation of PABA-GLU to a concentration enabling AbgAB to catalyze cleavage into p-aminobenzoate and glutamate [ ]. This entry represents a clade of AbgT proteins from Proteobacteria.

[ "GO:0015558", "GO:1902604" ]

[ "secondary active p-aminobenzoyl-glutamate transmembrane transporter activity", "p-aminobenzoyl-glutamate transmembrane transport" ]

[ "molecular_function", "biological_process" ]

2

[ "NCBIFAM" ]

[ "TIGR00819" ]

[ "ydaH" ]

[ 353 ]

1

[]

0

[ "4r1i" ]

1

[ "PUB00060288" ]

[ "17307853" ]

[ "Escherichia coli abg genes enable uptake and cleavage of the folate catabolite p-aminobenzoyl-glutamate." ]

[ 2007 ]

1

[ "IPR004697" ]

[]

1

0

1

[ "Pseudomonadota" ]

[ 353 ]

1

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

AbgT, Proteobacteria

AbgT_Proteobac

6

IPR011541

11,541

Nickel/cobalt transporter, high-affinity

Ni/Co_transpt_high_affinity

Family

14,415

false

High affinity nickel transporters are involved in the incorporation of nickel into H2-uptake hydrogenase [ , ] and urease [ ] enzymes and are essential for the expression of catalytically active hydrogenase and urease. Ion uptake is dependent on proton motive force. HoxN in Ralstonia eutropha (Alcaligenes eutrophus) is...

[ "GO:0015099", "GO:0035444", "GO:0005886" ]

[ "nickel cation transmembrane transporter activity", "nickel cation transmembrane transport", "plasma membrane" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PFAM" ]

[ "PF03824" ]

[ "NicO" ]

[ 14415 ]

1

[]

0

[]

0

[ "PUB00014814", "PUB00014815", "PUB00014816", "PUB00014817", "PUB00072950" ]

[ "7934894", "7651142", "8197192", "8288539", "17120142" ]

[ "A topological model for the high-affinity nickel transporter of Alcaligenes eutrophus.", "Helicobacter pylori nickel-transport gene nixA: synthesis of catalytically active urease in Escherichia coli independent of growth conditions.", "Bacterial genes involved in incorporation of nickel into a hydrogenase enzy...

[ 1994, 1995, 1994, 1994, 2007 ]

5

[]

[ "IPR004688" ]

0

1

0

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 124, 12593, 1557, 141 ]

4

[ "Escherichia coli (strain K12)", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 1, 1 ]

3

true

Family

Nickel/cobalt transporter, high-affinity

Ni/Co_transpt_high_affinity

9

IPR011542

11,542

SUF system FeS cluster assembly, SufD

SUF_FeS_clus_asmbl_SufD

Family

17,136

false

Iron-sulphur (FeS) clusters are important cofactors for numerous proteins involved in electron transfer, in redox and non-redox catalysis, in gene regulation, and as sensors of oxygen and iron. These functions depend on the various FeS cluster prosthetic groups, the most common being [2Fe-2S] and [4Fe-4S] [ ]. FeS clus...

[ "GO:0016226" ]

[ "iron-sulfur cluster assembly" ]

[ "biological_process" ]

1

[ "NCBIFAM" ]

[ "TIGR01981" ]

[ "sufD" ]

[ 17136 ]

1

[ "GP", "GP" ]

[ "GenProp0137", "GenProp1192" ]

[ "GP:GenProp0137", "GP:GenProp1192" ]

2

[ "1vh4", "2zu0", "5awf", "5awg" ]

4

[ "PUB00003442", "PUB00028014", "PUB00035635", "PUB00035636", "PUB00035637", "PUB00035638", "PUB00035639", "PUB00035640" ]

[ "8875867", "11498000", "16221578", "16211402", "16843540", "15937904", "17350000", "15278785" ]

[ "A modular domain of NifU, a nitrogen fixation cluster protein, is highly conserved in evolution.", "Incorporation of iron-sulphur clusters in membrane-bound proteins.", "How Escherichia coli and Saccharomyces cerevisiae build Fe/S proteins.", "Mechanisms of iron-sulfur cluster assembly: the SUF machinery.", ...

[ 1996, 2001, 2005, 2005, 2006, 2005, 2007, 2004 ]

8

[ "IPR055346" ]

[]

1

0

1

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 386, 16054, 384, 312 ]

4

[ "Arabidopsis thaliana", "Escherichia coli (strain K12)" ]

[ 5, 1 ]

2

true

Family

SUF system FeS cluster assembly, SufD

SUF_FeS_clus_asmbl_SufD

9

IPR011543

11,543

Restriction endonuclease, type II, BglI

Restrct_endonuc_II_BglI

Domain

23

false

This entry represents the structural domain of restriction endonuclease BglI [ ]. BglI recognises GCCNNNNNGGC and cleave after N-4.

[]

0

[ "PFAM" ]

[ "PF14562" ]

[ "Endonuc_BglI" ]

[ 23 ]

1

[]

0

[ "1dmu" ]

1

[ "PUB00028367" ]

[ "9736624" ]

[ "Crystal structure of restriction endonuclease BglI bound to its interrupted DNA recognition sequence." ]

[ 1998 ]

1

[]

0

null

[ "Bacteria", "freshwater metagenome" ]

[ 22, 1 ]

2

[]

0

true

Domain

Restriction endonuclease, type II, BglI

Restrct_endonuc_II_BglI

8

IPR011545

11,545

DEAD/DEAH-box helicase domain

DEAD/DEAH_box_helicase_dom

Domain

592,899

false

This entry represents the DNA-binding domain at the N-terminal in DEAD/DEAH box helicase and related proteins. This domain also contains motif III (S-A-T) which was proposed to participate in linking ATPase and helicase activities. DEAD-box and DEAH-box RNA helicases are essential enzymes involved in the unwinding of n...

[ "GO:0003676", "GO:0005524" ]

[ "nucleic acid binding", "ATP binding" ]

[ "molecular_function", "molecular_function" ]

2

[ "PFAM" ]

[ "PF00270" ]

[ "DEAD" ]

[ 592899 ]

1

[ "EC", "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACT...

[ "3.6.4", "3.6.4.13", "R-BTA-1169408", "R-BTA-156827", "R-BTA-159236", "R-BTA-1810476", "R-BTA-3134963", "R-BTA-429947", "R-BTA-6791226", "R-BTA-72163", "R-BTA-72187", "R-BTA-72649", "R-BTA-72702", "R-BTA-73856", "R-BTA-9013418", "R-BTA-975957", "R-BTA-9833482", "R-CEL-1169408", "...

[ "EC:3.6.4", "EC:3.6.4.13", "REACTOME:R-BTA-1169408", "REACTOME:R-BTA-156827", "REACTOME:R-BTA-159236", "REACTOME:R-BTA-1810476", "REACTOME:R-BTA-3134963", "REACTOME:R-BTA-429947", "REACTOME:R-BTA-6791226", "REACTOME:R-BTA-72163", "REACTOME:R-BTA-72187", "REACTOME:R-BTA-72649", "REACTOME:R-BT...

266

[ "1fuu", "1gku", "1gl9", "1gm5", "1hv8", "1oyw", "1oyy", "1q0u", "1qde", "1qva", "1s2m", "1t6n", "1vec", "1wp9", "1wrb", "1xti", "1xtj", "1xtk", "2db3", "2eyq", "2g9n", "2gxq", "2gxs", "2gxu", "2hxy", "2hyi", "2i4i", "2j0q", "2j0s", "2j0u", "2kbe", "2oxc"...

726

[ "PUB00033620", "PUB00054674", "PUB00094062" ]

[ "11545728", "20941364", "16935882" ]

[ "DExD/H box RNA helicases: from generic motors to specific dissociation functions.", "Comparative structural analysis of human DEAD-box RNA helicases.", "DExD/H box RNA helicases: multifunctional proteins with important roles in transcriptional regulation." ]

[ 2001, 2010, 2006 ]

3

[ "IPR014001" ]

[ "IPR033517", "IPR044113", "IPR044447", "IPR044728", "IPR044742", "IPR044756", "IPR044763", "IPR044764", "IPR044765", "IPR044773", "IPR049614" ]

1

11

0

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 7175, 278665, 297226, 5205, 4628 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus",...

[ 486, 73, 234, 180, 16, 420, 229, 46, 237, 272, 58, 44, 883 ]

13

true

Domain

DEAD/DEAH-box helicase domain

DEAD/DEAH_box_helicase_dom

2

IPR011546

11,546

Peptidase M41, FtsH extracellular

Pept_M41_FtsH_extracell

Domain

38,068

false

This domain is found in the FtsH family of proteins that include FtsH a membrane-bound ATP-dependent protease universally conserved in prokaryotes [ ]. The FtsH peptidases, which belong to MEROPS peptidase family M41 (clan MA(E)), efficiently degrade proteins that have a low thermodynamic stability - e.g. they lack rob...

[ "GO:0004176", "GO:0004222", "GO:0005524", "GO:0008270", "GO:0016020" ]

[ "ATP-dependent peptidase activity", "metalloendopeptidase activity", "ATP binding", "zinc ion binding", "membrane" ]

[ "molecular_function", "molecular_function", "molecular_function", "molecular_function", "cellular_component" ]

5

[ "PFAM" ]

[ "PF06480" ]

[ "FtsH_ext" ]

[ 38068 ]

1

[ "EC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "3.4.24.-", "PWY-8119", "R-BTA-8949664", "R-BTA-9837999", "R-CEL-8949664", "R-CEL-9837999", "R-HSA-8949664", "R-HSA-9837999", "R-MMU-8949664", "R-MMU-9837999", "R-RNO-8949664", "R-RNO-9837999", "R-SCE-9837999", "R-SPO-9837999" ]

[ "EC:3.4.24.-", "METACYC:PWY-8119", "REACTOME:R-BTA-8949664", "REACTOME:R-BTA-9837999", "REACTOME:R-CEL-8949664", "REACTOME:R-CEL-9837999", "REACTOME:R-HSA-8949664", "REACTOME:R-HSA-9837999", "REACTOME:R-MMU-8949664", "REACTOME:R-MMU-9837999", "REACTOME:R-RNO-8949664", "REACTOME:R-RNO-9837999",...

14

[ "2lna", "2muy", "4m8a", "4q0f", "4v0b", "7tdo", "7vhp", "7vhq", "7wi3", "7wi4", "9cz2" ]

11

[ "PUB00003579", "PUB00012628", "PUB00012629" ]

[ "7674922", "12667449", "12732516" ]

[ "Evolutionary families of metallopeptidases.", "Lack of a robust unfoldase activity confers a unique level of substrate specificity to the universal AAA protease FtsH.", "The ftsH gene of the wine bacterium Oenococcus oeni is involved in protection against environmental stress." ]

[ 1995, 2003, 2003 ]

3

[]

0

null

[ "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 27422, 10167, 3, 476 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus",...

[ 28, 1, 3, 5, 1, 31, 9, 1, 10, 13, 2, 1, 27 ]

13

true

Domain

Peptidase M41, FtsH extracellular

Pept_M41_FtsH_extracell

7

IPR011547

11,547

SLC26A/SulP transporter domain

SLC26A/SulP_dom

Domain

83,848

false

null

[ "GO:0016020" ]

[ "membrane" ]

[ "cellular_component" ]

1

[ "PFAM" ]

[ "PF00916" ]

[ "Sulfate_transp" ]

[ 83848 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-174362", "R-BTA-427601", "R-CEL-174362", "R-CEL-427601", "R-HSA-174362", "R-HSA-3560792", "R-HSA-427601", "R-HSA-5619046", "R-HSA-5619085", "R-HSA-9662361", "R-MMU-174362", "R-MMU-427601", "R-RNO-174362", "R-RNO-427601", "R-SCE-174362", "R-SCE-427601", "R-SPO-174362", "R-SPO...

[ "REACTOME:R-BTA-174362", "REACTOME:R-BTA-427601", "REACTOME:R-CEL-174362", "REACTOME:R-CEL-427601", "REACTOME:R-HSA-174362", "REACTOME:R-HSA-3560792", "REACTOME:R-HSA-427601", "REACTOME:R-HSA-5619046", "REACTOME:R-HSA-5619085", "REACTOME:R-HSA-9662361", "REACTOME:R-MMU-174362", "REACTOME:R-MMU...

19

[ "5da0", "5iof", "6ki1", "6rtc", "6rtf", "7ch1", "7lgu", "7lgw", "7lh2", "7lh3", "7lhv", "7s8x", "7s9a", "7s9b", "7s9c", "7s9d", "7s9e", "7sun", "7v73", "7v74", "7v75", "7wk1", "7wk7", "7wl2", "7wl7", "7wl8", "7wl9", "7wla", "7wlb", "7wle", "7xlm", "7xuh"...

59

[ "PUB00003771", "PUB00005419", "PUB00018267" ]

[ "7616962", "8140616", "10662676" ]

[ "Isolation of a cDNA from Saccharomyces cerevisiae that encodes a high affinity sulphate transporter at the plasma membrane.", "Similarities between a soybean nodulin, Neurospora crassa sulphate permease II and a putative human tumour suppressor.", "The STAS domain - a link between anion transporters and antisi...

[ 1995, 1994, 2000 ]

3

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Sym plasmid", "unclassified sequences", "uncultured Caudovirales phage" ]

[ 174, 44131, 39035, 1, 506, 1 ]

6

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus",...

[ 74, 15, 27, 16, 1, 50, 37, 4, 51, 40, 4, 4, 65 ]

13

true

Domain

SLC26A/SulP transporter domain

SLC26A/SulP_dom

9

IPR011548

11,548

3-hydroxyisobutyrate dehydrogenase

HIBADH

Family

10,137

false

3-hydroxyisobutyrate dehydrogenase is an enzyme that catalyzes the NAD+-dependent oxidation of 3-hydroxyisobutyrate to methylmalonate semialdehyde of the valine catabolism pathway. In Pseudomonas aeruginosa, 3-hydroxyisobutyrate dehydrogenase (mmsB) is co-induced with methylmalonate-semialdehyde dehydrogenase (mmsA) wh...

[ "GO:0008442", "GO:0051287" ]

[ "3-hydroxyisobutyrate dehydrogenase activity", "NAD binding" ]

[ "molecular_function", "molecular_function" ]

2

[ "NCBIFAM" ]

[ "TIGR01692" ]

[ "HIBADH" ]

[ 10137 ]

1

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "1.1.1.31", "R-BTA-70895", "R-CEL-70895", "R-DDI-70895", "R-DME-70895", "R-HSA-70895", "R-MMU-70895", "R-RNO-70895" ]

[ "EC:1.1.1.31", "REACTOME:R-BTA-70895", "REACTOME:R-CEL-70895", "REACTOME:R-DDI-70895", "REACTOME:R-DME-70895", "REACTOME:R-HSA-70895", "REACTOME:R-MMU-70895", "REACTOME:R-RNO-70895" ]

8

[ "2gf2", "2i9p", "3obb", "3q3c", "5y8g", "5y8h", "5y8i", "5y8j", "5y8k", "5y8l", "5y8m", "5y8n", "5y8o", "5y8p" ]

14

[ "PUB00002541", "PUB00002721", "PUB00013462" ]

[ "2647728", "1339433", "8766712" ]

[ "Cloning and sequence analysis of a cDNA for 3-hydroxyisobutyrate dehydrogenase. Evidence for its evolutionary relationship to other pyridine nucleotide-dependent dehydrogenases.", "Characterization of the mmsAB operon of Pseudomonas aeruginosa PAO encoding methylmalonate-semialdehyde dehydrogenase and 3-hydroxyi...

[ 1989, 1992, 1996 ]

3

[ "IPR015815" ]

[]

1

0

1

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 7223, 2876, 38 ]

3

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 5, 1, 2, 1, 3, 2, 1, 3, 4, 3 ]

10

true

Family

3-hydroxyisobutyrate dehydrogenase

HIBADH

7

IPR011549

11,549

Riboflavin-specific deaminase, C-terminal

RibD_C

Domain

15,027

false

Eubacterial riboflavin-specific deaminases have a zinc-binding domain, , toward the N terminus and this domain toward the C terminus. Yeast HTP reductase, a riboflavin-biosynthetic enzyme, and several archaeal proteins related to riboflavin biosynthesis consist only of this domain and lack the zinc-binding domain.

[ "GO:0008703", "GO:0050661", "GO:0009231" ]

[ "5-amino-6-(5-phosphoribosylamino)uracil reductase activity", "NADP binding", "riboflavin biosynthetic process" ]

[ "molecular_function", "molecular_function", "biological_process" ]

3

[ "NCBIFAM" ]

[ "TIGR00227" ]

[ "ribD_Cterm" ]

[ 15027 ]

1

[ "EC" ]

[ "1.1.1" ]

[ "EC:1.1.1" ]

1

[ "2azn", "2b3z", "2d5n", "2g6v", "2o7p", "2obc", "3ex8", "3zpc", "3zpg", "4g3m", "4ha7", "4ha9", "5xux", "5xv0", "5xv2", "5xv5", "6p8c", "8dq9", "8dqb", "8dqc" ]

20

[]

0

[ "IPR002734" ]

[]

1

0

1

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 767, 13225, 840, 195 ]

4

[ "Arabidopsis thaliana", "Escherichia coli (strain K12)", "Oryza sativa subsp. japonica", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Zea mays" ]

[ 6, 1, 5, 1, 5 ]

5

true

Domain

Riboflavin-specific deaminase, C-terminal

RibD_C

9

IPR011551

11,551

NTP pyrophosphohydrolase MazG

NTP_PyrPHydrolase_MazG

Family

20,227

false

MazG hydrolyses all canonical nucleoside and deoxyribonucleoside triphosphates as well as mutagenic dUTP and 8-oxo-dGTP, converting them to the corresponding nucleoside monophosphates and diphosphate. The enzyme is required to maintain mycobacterial capacity to respond to oxidative stress through degradation of oxidati...

[]

0

[ "PANTHER", "NCBIFAM" ]

[ "PTHR30522", "TIGR00444" ]

[ "", "mazG" ]

[ 20225, 16215 ]

2

[ "EC" ]

[ "3.6.1.8" ]

[ "EC:3.6.1.8" ]

1

[ "2yxh", "3cra", "3crc", "7yh5" ]

4

[ "PUB00013554", "PUB00051103", "PUB00078110", "PUB00078111" ]

[ "12657645", "18353782", "16390452", "20529853" ]

[ "Thermotoga maritima MazG protein has both nucleoside triphosphate pyrophosphohydrolase and pyrophosphatase activities.", "Crystal structure of Escherichia coli MazG, the regulator of nutritional stress response.", "MazG -- a regulator of programmed cell death in Escherichia coli.", "Mycobacterial MazG is a n...

[ 2003, 2008, 2006, 2010 ]

4

[]

[ "IPR024180" ]

0

1

0

[ "Archaea", "Bacteria", "Eukaryota", "Siphoviridae sp. ctPAi1", "unclassified sequences" ]

[ 4, 19641, 62, 1, 519 ]

5

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

NTP pyrophosphohydrolase MazG

NTP_PyrPHydrolase_MazG

3

IPR011552

11,552

Tellurite resistance protein TehA/malic acid transport protein

TehA/Mae1

Family

1,071

false

This entry includes TehA from Escherichia coli and Malic acid transport protein (Mae1) from Schizosaccharomyces pombe. TehA has been implicated in resistance to tellurite [ ]. It has proflavin and ethidium efflux activity [ ]. Mae1 functions in the uptake of malate and other dicarboxylates by a proton symport mechanism...

[ "GO:0016020" ]

[ "membrane" ]

[ "cellular_component" ]

1

[ "NCBIFAM" ]

[ "TIGR00816" ]

[ "tdt" ]

[ 1071 ]

1

[]

0

[ "3m71", "3m72", "3m73", "3m74", "3m75", "3m76", "3m77", "3m78", "3m7b", "3m7c", "3m7e", "3m7l", "4ycr", "8en9", "8vi2", "8vi3", "8vi4", "8vi5" ]

18

[ "PUB00017439", "PUB00062355" ]

[ "8169225", "9021204" ]

[ "Location of a potassium tellurite resistance operon (tehA tehB) within the terminus of Escherichia coli K-12.", "Expression of Escherichia coli TehA gives resistance to antiseptics and disinfectants similar to that conferred by multidrug resistance efflux pumps." ]

[ 1994, 1997 ]

2

[ "IPR004695" ]

[ "IPR039264" ]

1

0

[ "Bacteria", "Methanobacteriota", "Opisthokonta" ]

[ 1022, 42, 7 ]

3

[ "Escherichia coli (strain K12)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 1 ]

2

true

Family

Tellurite resistance protein TehA/malic acid transport protein

TehA/Mae1

9

IPR011553

11,553

Translocation protein Sec62, ascomycota

Sec62_asco

Family

1,643

false

Members of the NSCC2 family have been sequenced from various fungal and animal species including Saccharomyces cerevisiae, Drosophila melanogaster and Homo sapiens. These proteins are the Sec62 proteins, believed to be associated with the Sec61 and Sec63 constituents of the general protein secretary systems of yeast mi...

[ "GO:0015031", "GO:0005789" ]

[ "protein transport", "endoplasmic reticulum membrane" ]

[ "biological_process", "cellular_component" ]

2

[ "NCBIFAM" ]

[ "TIGR00869" ]

[ "sec62" ]

[ 1643 ]

1

[]

0

[ "6zzz", "7aft", "7kal", "7kam" ]

4

[]

0

[ "IPR004728" ]

[]

1

0

1

[ "Eukaryota" ]

[ 1643 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 1, 1 ]

3

true

Family

Translocation protein Sec62, ascomycota

Sec62_asco

5

IPR011555

11,555

V-ATPase proteolipid subunit C, eukaryotic

ATPase_proteolipid_su_C_euk

Family

9,231

false

Transmembrane ATPases are membrane-bound enzyme complexes/ion transporters that use ATP hydrolysis to drive the transport of protons across a membrane. Some transmembrane ATPases also work in reverse, harnessing the energy from a proton gradient, using the flux of ions across the membrane via the ATPase proton channel ...

[ "GO:0046961", "GO:1902600", "GO:0033179" ]

[ "proton-transporting ATPase activity, rotational mechanism", "proton transmembrane transport", "proton-transporting V-type ATPase, V0 domain" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "NCBIFAM" ]

[ "TIGR01100" ]

[ "V_ATP_synt_C" ]

[ 9231 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-CEL-1222556", "R-CEL-6798695", "R-CEL-77387", "R-CEL-917977", "R-CEL-9639288", "R-CEL-983712", "R-DDI-1222556", "R-DDI-6798695", "R-DDI-77387", "R-DDI-917977", "R-DDI-9639288", "R-DME-1222556", "R-DME-6798695", "R-DME-77387", "R-DME-917977", "R-DME-9639288", "R-DME-983712", "R-H...

[ "REACTOME:R-CEL-1222556", "REACTOME:R-CEL-6798695", "REACTOME:R-CEL-77387", "REACTOME:R-CEL-917977", "REACTOME:R-CEL-9639288", "REACTOME:R-CEL-983712", "REACTOME:R-DDI-1222556", "REACTOME:R-DDI-6798695", "REACTOME:R-DDI-77387", "REACTOME:R-DDI-917977", "REACTOME:R-DDI-9639288", "REACTOME:R-DME...

46

[ "3j9t", "3j9u", "3j9v", "5tj5", "5vox", "5voy", "5voz", "6c6l", "6m0r", "6m0s", "6o7t", "6o7u", "6o7v", "6o7w", "6o7x", "6pe4", "6pe5", "6vq6", "6vq7", "6vq8", "6vqc", "6vqg", "6vqh", "6wlw", "6wm2", "6wm3", "6wm4", "6xbw", "6xby", "7fda", "7fdb", "7fdc"...

75

[ "PUB00020603", "PUB00020604", "PUB00020608", "PUB00020609", "PUB00020629", "PUB00020631", "PUB00068786", "PUB00068787", "PUB00068788", "PUB00068789" ]

[ "15473999", "15078220", "15907459", "15629643", "15951435", "14635779", "20450191", "18937357", "1385979", "9741106" ]

[ "The evolution of A-, F-, and V-type ATP synthases and ATPases: reversals in function and changes in the H+/ATP coupling ratio.", "Mechanisms of ATPases--a multi-disciplinary approach.", "A new view of an old pore.", "A structural model of the vacuolar ATPase from transmission electron microscopy.", "Cystei...

[ 2004, 2004, 2005, 2005, 2005, 2003, 2010, 2008, 1992, 1998 ]

10

[ "IPR000245" ]

[]

1

0

1

[ "Eukaryota" ]

[ 9231 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 13, 3, 2, 8, 2, 6, 2, 11, 5, 2, 2, 30 ]

12

true

Family

V-ATPase proteolipid subunit C, eukaryotic

ATPase_proteolipid_su_C_euk

9

IPR011556

11,556

Glutamate--cysteine ligase, plant-type

Glut_cys_lig_pln_type

Family

4,289

false

These sequences represent one of two highly dissimilar forms of glutamate--cysteine ligase (gamma-glutamylcysteine synthetase), an enzyme of glutathione biosynthesis. The other group is represented by . This form is found in plants (with a probable transit peptide), root nodule and other bacteria, but not Escherichia c...

[ "GO:0004357", "GO:0006750" ]

[ "glutamate-cysteine ligase activity", "glutathione biosynthetic process" ]

[ "molecular_function", "biological_process" ]

2

[ "NCBIFAM" ]

[ "TIGR01436" ]

[ "glu_cys_lig_pln" ]

[ 4289 ]

1

[ "EC", "GP", "GP", "METACYC", "METACYC", "METACYC" ]

[ "6.3.2.2", "GenProp0030", "GenProp1359", "PWY-6840", "PWY-7255", "PWY-8043" ]

[ "EC:6.3.2.2", "GP:GenProp0030", "GP:GenProp1359", "METACYC:PWY-6840", "METACYC:PWY-7255", "METACYC:PWY-8043" ]

6

[ "2gwc", "2gwd", "6gmo" ]

3

[ "PUB00060032", "PUB00095251" ]

[ "20420449", "26774486" ]

[ "In vitro reconstitution of Mycobacterial ergothioneine biosynthesis.", "Ergothioneine Maintains Redox and Bioenergetic Homeostasis Essential for Drug Susceptibility and Virulence of Mycobacterium tuberculosis." ]

[ 2010, 2016 ]

2

[ "IPR035434" ]

[]

1

0

1

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 3370, 894, 25 ]

3

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 5, 4, 8 ]

3

true

Family

Glutamate--cysteine ligase, plant-type

Glut_cys_lig_pln_type

4

IPR011557

11,557

DNA gyrase, subunit B

GyrB

Family

26,507

false

Topoisomerase II (called gyrase in bacteria) primarily introduces negative supercoils into DNA. In bacteria, topoisomerase II consists of two polypeptide subunits, gyrA and gyrB, which form a heterotetramer: (BA)2. In most eukaryotes, topoisomerase II consists of a single polypeptide, where the N-and C-terminal regions...

[ "GO:0003677", "GO:0003918", "GO:0005524", "GO:0006265", "GO:0005694" ]

[ "DNA binding", "DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity", "ATP binding", "DNA topological change", "chromosome" ]

[ "molecular_function", "molecular_function", "molecular_function", "biological_process", "cellular_component" ]

5

[ "HAMAP", "NCBIFAM" ]

[ "MF_01898", "TIGR01059" ]

[ "GyrB", "gyrB" ]

[ 25296, 26264 ]

2

[ "EC", "GP", "GP", "REACTOME", "REACTOME" ]

[ "5.6.2.2", "GenProp0699", "GenProp1178", "R-HSA-9638771", "R-HSA-9913143" ]

[ "EC:5.6.2.2", "GP:GenProp0699", "GP:GenProp1178", "REACTOME:R-HSA-9638771", "REACTOME:R-HSA-9913143" ]

5

[ "6gau", "6gav", "6rks", "6rku", "6rkv", "6rkw", "7z9c", "7z9g", "7z9k", "7z9m", "8qdx", "8qqi", "8qqs", "8qqu", "8s7k", "8s7o", "9gbv", "9ggq" ]

18

[ "PUB00005437", "PUB00016842", "PUB00020793", "PUB00020794", "PUB00020795", "PUB00020803" ]

[ "7770916", "11395412", "12596227", "12042765", "7980433", "8982450" ]

[ "The mechanisms of DNA topoisomerases.", "DNA topoisomerases: structure, function, and mechanism.", "Phylogenomics of type II DNA topoisomerases.", "Cellular roles of DNA topoisomerases: a molecular perspective.", "Structure and function of type II DNA topoisomerases.", "Bacterial diversity based on type ...

[ 1995, 2001, 2003, 2002, 1994, 1996 ]

6

[ "IPR000565" ]

[]

1

0

1

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 513, 25156, 531, 307 ]

4

[ "Arabidopsis thaliana", "Escherichia coli (strain K12)", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 8, 1, 2, 1 ]

4

true

Family

DNA gyrase, subunit B

GyrB

5

IPR011559

11,559

Initiation factor 2B alpha/beta/delta

Initiation_fac_2B_a/b/d

Family

14,393

false

This family describes part of the eukaryotic translation initiation factor 2B superfamily. It includes eukaryotic translation initiation factor 2B (eIF-2B) subunits 1 and 2 (alpha and beta) and related proteins. Members of this branch of the family are predominantly uncharacterised with respect to function and are foun...

[]

0

[ "NCBIFAM" ]

[ "TIGR00524" ]

[ "eIF-2B_rel" ]

[ 14393 ]

1

[ "EC", "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "5.3.1", "5.3.1.23", "PWY-4361", "PWY-7174", "PWY-8130", "PWY-8131", "PWY-8132", "R-CEL-1237112", "R-DME-1237112", "R-DRE-1237112", "R-HSA-1237112", "R-MMU-1237112", "R-RNO-1237112", "R-SCE-1237112", "R-SPO-1237112", "R-XTR-1237112" ]

[ "EC:5.3.1", "EC:5.3.1.23", "METACYC:PWY-4361", "METACYC:PWY-7174", "METACYC:PWY-8130", "METACYC:PWY-8131", "METACYC:PWY-8132", "REACTOME:R-CEL-1237112", "REACTOME:R-DME-1237112", "REACTOME:R-DRE-1237112", "REACTOME:R-HSA-1237112", "REACTOME:R-MMU-1237112", "REACTOME:R-RNO-1237112", "REACTO...

16

[ "1t5o", "1t9k", "1w2w", "2a0u", "2yrf", "2yvk", "3a11", "3a9c", "3vm6", "4ldq", "4ldr", "5yfj", "5yfs", "5yft", "5yfu", "5yfv", "5yfw", "5yfx", "5yg5", "5yg6", "5yg7", "5yg8", "5yg9", "5yga", "6a34", "6a35" ]

26

[ "PUB00016714", "PUB00016716" ]

[ "15215245", "14551435" ]

[ "Crystal structure of yeast Ypr118w, a methylthioribose-1-phosphate isomerase related to regulatory eIF2B subunits.", "A functional link between RuBisCO-like protein of Bacillus and photosynthetic RuBisCO." ]

[ 2004, 2003 ]

2

[ "IPR000649" ]

[ "IPR005250", "IPR005251" ]

1

2

0

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 1010, 9405, 3706, 272 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 5, 1, 1, 1, 1, 2, 1, 2, 5, 1, 1, 4 ]

12

true

Family

Initiation factor 2B alpha/beta/delta

Initiation_fac_2B_a/b/d

5

IPR011564

11,564

Telomeric single stranded DNA binding POT1/Cdc13

Telomer_end-bd_POT1/Cdc13

Domain

4,698

false

This domain binds single stranded telomeric DNA and adopts an OB fold [ ]. It includes the proteins POT1 and Cdc13 which have been shown to regulate telomere length, replication and capping [ , , ]. POT1 is one component of the shelterin complex that protects telomere-ends from attack by DNA-repair mechanisms [ , ].

[ "GO:0003677", "GO:0000723", "GO:0000781" ]

[ "DNA binding", "telomere maintenance", "chromosome, telomeric region" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PFAM", "SMART" ]

[ "PF02765", "SM00976" ]

[ "POT1", "Telo_bind" ]

[ 4549, 4115 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-GGA-418124", "R-HSA-110328", "R-HSA-110329", "R-HSA-110330", "R-HSA-110331", "R-HSA-1221632", "R-HSA-171306", "R-HSA-171319", "R-HSA-174411", "R-HSA-174414", "R-HSA-174417", "R-HSA-174430", "R-HSA-174437", "R-HSA-2559586", "R-HSA-9670095", "R-MMU-110330", "R-MMU-110331", "R-MMU-...

[ "REACTOME:R-GGA-418124", "REACTOME:R-HSA-110328", "REACTOME:R-HSA-110329", "REACTOME:R-HSA-110330", "REACTOME:R-HSA-110331", "REACTOME:R-HSA-1221632", "REACTOME:R-HSA-171306", "REACTOME:R-HSA-171319", "REACTOME:R-HSA-174411", "REACTOME:R-HSA-174414", "REACTOME:R-HSA-174417", "REACTOME:R-HSA-17...

26

[ "1jb7", "1k8g", "1kix", "1kxl", "1otc", "1pa6", "1ph1", "1ph2", "1ph3", "1ph4", "1ph5", "1ph6", "1ph7", "1ph8", "1ph9", "1phj", "1qzg", "1qzh", "1s40", "1xjv", "2i0q", "3kjo", "3kjp", "6bwy", "6lbr", "7cuh", "7qxb", "7qxs", "8sh0", "8sh1", "8soj", "8sok"...

32

[ "PUB00026858", "PUB00053824", "PUB00053825", "PUB00053826", "PUB00066756", "PUB00066757" ]

[ "11935027", "11230149", "18066078", "16943437", "1239117", "19228335" ]

[ "Conserved structure for single-stranded telomeric DNA recognition.", "Cdc13 both positively and negatively regulates telomere replication.", "Pot1 and cell cycle progression cooperate in telomere length regulation.", "Vertebrate POT1 restricts G-overhang length and prevents activation of a telomeric DNA dama...

[ 2002, 2001, 2008, 2006, 1975, 2009 ]

6

[]

0

null

[ "Eukaryota" ]

[ 4698 ]

1

[ "Arabidopsis thaliana", "Danio rerio", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (st...

[ 15, 28, 9, 7, 2, 3, 7, 1, 1, 14 ]

10

true

Domain

Telomeric single stranded DNA binding POT1/Cdc13

Telomer_end-bd_POT1/Cdc13

8

IPR011566

11,566

Ubiquinone biosynthesis protein Coq7

Ubq_synth_Coq7

Family

8,757

false

Coq7 (also known as Clk-1 and CAT5) is a di-iron carboxylate protein occurring in both prokaryotes and eukaryotes that is essential for ubiquinone biosynthesis [ , ]. It has been implicated in the ageing process as mutations in the Caenorhabditis elegans gene lead to increased lifespan [ ]. Coq7 is a membrane-bound pro...

[ "GO:0004497", "GO:0006744" ]

[ "monooxygenase activity", "ubiquinone biosynthetic process" ]

[ "molecular_function", "biological_process" ]

2

[ "HAMAP", "PFAM", "PANTHER", "CDD" ]

[ "MF_01658", "PF03232", "PTHR11237", "cd01042" ]

[ "COQ7", "COQ7", "", "DMQH" ]

[ 7508, 8756, 8466, 8026 ]

4

[ "EC", "GP", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "1.14.99.60", "GenProp0136", "PWY-5855", "PWY-5856", "PWY-5857", "PWY-5870", "PWY-5871", "PWY-5872", "PWY-5873", "PWY-6708", "PWY-7230", "R-CEL-2142789", "R-DDI-2142789", "R-HSA-2142789", "R-MMU-2142789", "R-RNO-2142789", "R-SCE-2142789", "R-SPO-2142789" ]

[ "EC:1.14.99.60", "GP:GenProp0136", "METACYC:PWY-5855", "METACYC:PWY-5856", "METACYC:PWY-5857", "METACYC:PWY-5870", "METACYC:PWY-5871", "METACYC:PWY-5872", "METACYC:PWY-5873", "METACYC:PWY-6708", "METACYC:PWY-7230", "REACTOME:R-CEL-2142789", "REACTOME:R-DDI-2142789", "REACTOME:R-HSA-2142789...

18

[ "7ssp", "7sss" ]

2

[ "PUB00054991", "PUB00054992", "PUB00054993", "PUB00054994", "PUB00054995" ]

[ "8621692", "9823893", "9020081", "11435415", "20923139" ]

[ "The COQ7 gene encodes a protein in saccharomyces cerevisiae necessary for ubiquinone biosynthesis.", "The genome sequence of Rickettsia prowazekii and the origin of mitochondria.", "Structural and functional conservation of the Caenorhabditis elegans timing gene clk-1.", "A new member of the family of di-iro...

[ 1996, 1998, 1997, 2001, 2010 ]

5

[]

[ "IPR047809" ]

0

1

0

[ "Bacteria", "Eukaryota", "Halorubrum tibetense", "unclassified sequences" ]

[ 4981, 3673, 1, 102 ]

4

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strai...

[ 1, 1, 2, 8, 4, 1, 3, 1, 1 ]

9

true

Family

Ubiquinone biosynthesis protein Coq7

Ubq_synth_Coq7

9

IPR011576

11,576

Pyridoxamine 5'-phosphate oxidase, N-terminal

Pyridox_Oxase_N

Domain

84,045

false

Pyridoxamine 5'-phosphate oxidase (PNPOx; ) is a FMN flavoprotein that catalyses the oxidation of pyridoxamine-5-P (PMP) and pyridoxine-5-P (PNP) to pyridoxal-5-P (PLP). This reaction serves as the terminal step in the de novo biosynthesis of PLP in Escherichia coli and as a part of the salvage pathway of this coenzyme...

[]

0

[ "PFAM" ]

[ "PF01243" ]

[ "PNPOx_N" ]

[ 84045 ]

1

[ "EC", "METACYC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "1.4.3.5", "PWY-7204", "PWY-7282", "R-BTA-964975", "R-CEL-964975", "R-DDI-964975", "R-HSA-964975", "R-MMU-964975", "R-RNO-964975", "R-SCE-964975", "R-SPO-964975" ]

[ "EC:1.4.3.5", "METACYC:PWY-7204", "METACYC:PWY-7282", "REACTOME:R-BTA-964975", "REACTOME:R-CEL-964975", "REACTOME:R-DDI-964975", "REACTOME:R-HSA-964975", "REACTOME:R-MMU-964975", "REACTOME:R-RNO-964975", "REACTOME:R-SCE-964975", "REACTOME:R-SPO-964975" ]

11

[ "1axj", "1ci0", "1dnl", "1flm", "1g76", "1g77", "1g78", "1g79", "1jnw", "1nrg", "1rfe", "1t9m", "1ty9", "1vl7", "1w9a", "1wli", "1wlk", "1wv4", "1xxo", "1y30", "2a2j", "2aq6", "2arz", "2asf", "2e83", "2fhq", "2hhz", "2hq7", "2htd", "2iab", "2ig6", "3a20"...

69

[ "PUB00016342", "PUB00016343", "PUB00024258", "PUB00055044", "PUB00081964", "PUB00155384", "PUB00155385" ]

[ "12824491", "12686112", "10903950", "20675471", "26327315", "38284493", "23897464" ]

[ "Structure and properties of recombinant human pyridoxine 5'-phosphate oxidase.", "Structure and mechanism of Escherichia coli pyridoxine 5'-phosphate oxidase.", "X-ray structure of Escherichia coli pyridoxine 5'-phosphate oxidase complexed with FMN at 1.8 A resolution.", "Unexpected abundance of coenzyme F(4...

[ 2003, 2003, 2000, 2010, 2015, 2024, 2013 ]

7

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Pleetrevirus", "unclassified sequences" ]

[ 1414, 74822, 6734, 2, 1073 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus",...

[ 6, 1, 1, 4, 1, 6, 1, 2, 8, 2, 2, 2, 13 ]

13

true

Domain

Pyridoxamine 5'-phosphate oxidase, N-terminal

Pyridox_Oxase_N

9

IPR011577

11,577

Cytochrome b561, bacterial/Ni-hydrogenase

Cyt_b561_bac/Ni-Hgenase

Domain

43,963

false

Cytochrome b561 is an integral membrane and electron transport protein, that binds two haem groups non-covalently. This domain is also found in a number of nickel-dependent hydrogenase subunits which are also B-type cytochromes that interact with quinones and anchor the hydrogenase to the membrane. This domain is found...

[ "GO:0009055", "GO:0016020" ]

[ "electron transfer activity", "membrane" ]

[ "molecular_function", "cellular_component" ]

2

[ "PFAM" ]

[ "PF01292" ]

[ "Ni_hydr_CYTB" ]

[ 43963 ]

1

[]

0

[ "1kqf", "1kqg", "4gd3", "5oc0", "6g94" ]

5

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Myoviridae sp. ctGBP5", "unclassified sequences" ]

[ 195, 43126, 184, 1, 457 ]

5

[ "Escherichia coli (strain K12)" ]

[ 7 ]

1

true

Domain

Cytochrome b561, bacterial/Ni-hydrogenase

Cyt_b561_bac/Ni-Hgenase

6

IPR011579

11,579

ATPase domain

ATPase_dom

Domain

6,591

false

This domain contains a conserved P-loop motif that is involved in binding ATP [ ].

[ "GO:0005524" ]

[ "ATP binding" ]

[ "molecular_function" ]

1

[ "PFAM" ]

[ "PF01637" ]

[ "ATPase_2" ]

[ 6591 ]

1

[]

0

[ "2fna", "2qen" ]

2

[ "PUB00016655" ]

[ "9045616" ]

[ "Evidence for a family of archaeal ATPases." ]

[ 1997 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 2039, 3940, 480, 3, 129 ]

5

[ "Mus musculus" ]

[ 1 ]

1

true

Domain

ATPase domain

ATPase_dom

9

IPR011583

11,583

Chitinase II/V-like, catalytic domain

Chitinase_II/V-like_cat

Domain

64,151

false

This entry represents the catalytic domain of a group of proteins from the glycoside hydrolase, family 18 . Members of this family belong to the chitinase class II/V and IDGF (Imaginal disk growth factor) groups, which includes chitinase, chitodextrinase and the killer toxin of Kluyveromyces lactis (Yeast) (Candida sph...

[ "GO:0008061" ]

[ "chitin binding" ]

[ "molecular_function" ]

1

[ "SMART" ]

[ "SM00636" ]

[ "Glyco_18" ]

[ 64151 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-114608", "R-CEL-189085", "R-CEL-6798695", "R-DDI-114608", "R-DME-189085", "R-DME-6798695", "R-DRE-114608", "R-HSA-114608", "R-HSA-189085", "R-HSA-2534343", "R-HSA-6798695", "R-MMU-114608", "R-MMU-189085", "R-MMU-2534343", "R-MMU-6798695", "R-PFA-189085", "R-PFA-6798695", "R-...

[ "REACTOME:R-BTA-114608", "REACTOME:R-CEL-189085", "REACTOME:R-CEL-6798695", "REACTOME:R-DDI-114608", "REACTOME:R-DME-189085", "REACTOME:R-DME-6798695", "REACTOME:R-DRE-114608", "REACTOME:R-HSA-114608", "REACTOME:R-HSA-189085", "REACTOME:R-HSA-2534343", "REACTOME:R-HSA-6798695", "REACTOME:R-MMU...

23

[ "1ctn", "1d2k", "1e15", "1e6n", "1e6p", "1e6r", "1e6z", "1e9l", "1edq", "1ehn", "1eib", "1ffq", "1ffr", "1goi", "1gpf", "1guv", "1h0g", "1h0i", "1hjv", "1hjw", "1hjx", "1hki", "1hkj", "1hkk", "1hkm", "1itx", "1jnd", "1jne", "1k9t", "1kfw", "1lg1", "1lg2"...

343

[ "PUB00004870", "PUB00005266", "PUB00084156", "PUB00095662" ]

[ "7624375", "8535779", "22550243", "16776685" ]

[ "Conserved catalytic machinery and the prediction of a common fold for several families of glycosyl hydrolases.", "Structures and mechanisms of glycosyl hydrolases.", "Chitinase-like proteins in lung injury, repair, and metastasis.", "The chitinase allergens Der p 15 and Der p 18 from Dermatophagoides pterony...

[ 1995, 1995, 2012, 2006 ]

4

[ "IPR001223" ]

[ "IPR041704", "IPR047898" ]

1

2

0

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 131, 25647, 37953, 197, 223 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 52, 31, 45, 44, 35, 22, 8, 7, 36, 1, 12 ]

11

true

Domain

Chitinase II/V-like, catalytic domain

Chitinase_II/V-like_cat

5

IPR011584

11,584

Green fluorescent protein-related

GFP-related

Family

930

false

The green fluorescent protein (GFP) is found in the jellyfish (Aequorea victoria), and functions as an energy-transfer acceptor. It fluoresces in vivo upon receiving energy from the Ca 2+ -activated photoprotein aequorin. The protein absorbs light maximally at 395 nm and exhibits a smaller absorbance peak at 470 nm. Th...

[ "GO:0008218" ]

[ "bioluminescence" ]

[ "biological_process" ]

1

[ "PFAM" ]

[ "PF01353" ]

[ "GFP" ]

[ 930 ]

1

[]

0

[ "1b9c", "1bfp", "1c4f", "1cv7", "1ema", "1emb", "1emc", "1eme", "1emf", "1emg", "1emk", "1eml", "1emm", "1f09", "1f0b", "1g7k", "1gfl", "1ggx", "1h6r", "1hcj", "1huy", "1jby", "1jbz", "1jc0", "1jc1", "1kp5", "1kyp", "1kyr", "1kys", "1mou", "1mov", "1myw"...

1,352

[ "PUB00020644", "PUB00020645" ]

[ "12325128", "10852900" ]

[ "Family of the green fluorescent protein: journey to the end of the rainbow.", "Natural animal coloration can Be determined by a nonfluorescent green fluorescent protein homolog." ]

[ 2002, 2000 ]

2

[]

[ "IPR000786" ]

0

1

0

[ "Bacteria", "Eukaryota", "Viruses" ]

[ 29, 878, 23 ]

3

[ "Homo sapiens" ]

[ 1 ]

1

true

Family

Green fluorescent protein-related

GFP-related

7

IPR011589

11,589

MJ1127-like

Family

724

false

This entry represents Uncharacterized protein MJ1127 and proteins that are related to a large superfamily of metalloenzymes [ ]. It shares protein sequence similarity with TatD, which is a DNase that is also part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characte...

[]

0

[ "PIRSF", "PANTHER" ]

[ "PIRSF004961", "PTHR42206" ]

[ "UCP004961_TatD", "" ]

[ 649, 724 ]

2

[]

0

[]

0

[ "PUB00004994", "PUB00007123", "PUB00056814" ]

[ "9144792", "10747959", "19343049" ]

[ "An evolutionary treasure: unification of a broad set of amidohydrolases related to urease.", "TatD is a cytoplasmic protein with DNase activity. No requirement for TatD family proteins in sec-independent protein export.", "TatD is a central component of a Tat translocon-initiated quality control system for exp...

[ 1997, 2000, 2009 ]

3

[ "IPR001130" ]

[]

1

0

1

[ "Archaea", "unclassified sequences", "uncultured Rhodobacterales bacterium HF0010_04M21" ]

[ 702, 21, 1 ]

3

[]

0

true

Family

MJ1127-like

8

IPR011590

11,590

Transcription elongation factor Spt5, archaeal

Spt5_arc

Family

969

false

Transcription elongation factor Spt5 is composed of a NusG N-terminal (NGN) domain and a KOW domain, similar to bacterial NusG [ ]. It forms heterodimer with Spt4 and stimulates transcription elongation [ ]. Its NGN domain closes the RNAP active centre cleft to lock nucleic acids and render the elongation complex stabl...

[ "GO:0003746" ]

[ "translation elongation factor activity" ]

[ "molecular_function" ]

1

[ "HAMAP", "NCBIFAM" ]

[ "MF_00950", "TIGR00405" ]

[ "Spt5_arch", "KOW_elon_Spt5" ]

[ 881, 968 ]

2

[]

0

[ "3ewg", "3lpe", "3p8b", "3qqc", "4zn1", "4zn3", "8oki", "8p2i", "9bct", "9bcu" ]

10

[ "PUB00068843", "PUB00068844" ]

[ "21386817", "21187417" ]

[ "Architecture of the RNA polymerase-Spt4/5 complex and basis of universal transcription processivity.", "RNA polymerase and transcription elongation factor Spt4/5 complex structure." ]

[ 2011, 2011 ]

2

[]

0

null

[ "Archaea", "Bacteria", "ecological metagenomes" ]

[ 931, 4, 34 ]

3

[]

0

true

Family

Transcription elongation factor Spt5, archaeal

Spt5_arc

3

IPR011598

11,598

Myc-type, basic helix-loop-helix (bHLH) domain

bHLH_dom

Domain

262,657

false

null

[ "GO:0046983" ]

[ "protein dimerization activity" ]

[ "molecular_function" ]

1

[ "PFAM", "PFAM", "PFAM", "PFAM", "PROFILE", "SMART" ]

[ "PF00010", "PF23171", "PF23173", "PF23176", "PS50888", "SM00353" ]

[ "HLH", "bHLH_HIF1A", "bHLH_SAC51", "bHLH_LHW", "BHLH", "HLH" ]

[ 216638, 10109, 4949, 3405, 259767, 231408 ]

6

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-525793", "R-BTA-5689880", "R-BTA-8866911", "R-BTA-9018519", "R-BTA-9824585", "R-CEL-1234158", "R-CEL-1234176", "R-CEL-163358", "R-CEL-1655829", "R-CEL-191273", "R-CEL-3232118", "R-CEL-525793", "R-CEL-5689880", "R-CEL-8951664", "R-CEL-9768919", "R-CEL-9824594", "R-CEL-9856649",...

[ "REACTOME:R-BTA-525793", "REACTOME:R-BTA-5689880", "REACTOME:R-BTA-8866911", "REACTOME:R-BTA-9018519", "REACTOME:R-BTA-9824585", "REACTOME:R-CEL-1234158", "REACTOME:R-CEL-1234176", "REACTOME:R-CEL-163358", "REACTOME:R-CEL-1655829", "REACTOME:R-CEL-191273", "REACTOME:R-CEL-3232118", "REACTOME:R...

235

[ "1a0a", "1am9", "1an2", "1an4", "1hlo", "1mdy", "1nkp", "1nlw", "1r05", "1ukl", "2lfh", "2mh3", "2ql2", "2ypa", "2ypb", "3u5v", "4ath", "4ati", "4atk", "4aya", "4f3l", "4h10", "4zp4", "4zph", "4zpk", "4zpr", "4zqd", "5eyo", "5gnj", "5i4z", "5i50", "5nj8"...

107

[ "PUB00000825", "PUB00000846", "PUB00001514", "PUB00004457", "PUB00078281", "PUB00107570", "PUB00107571" ]

[ "2493990", "2175254", "1521738", "8139914", "17626058", "11292861", "11566883" ]

[ "A new DNA binding and dimerization motif in immunoglobulin enhancer binding, daughterless, MyoD, and myc proteins.", "CeMyoD accumulation defines the body wall muscle cell fate during C. elegans embryogenesis.", "Function of the c-Myc oncoprotein.", "The expression pattern of Id4, a novel dominant negative h...

[ 1989, 1990, 1992, 1994, 2007, 2001, 2001 ]

7

[]

[ "IPR015789", "IPR024098", "IPR024100", "IPR032644", "IPR032655", "IPR032656", "IPR032657", "IPR032658", "IPR032659", "IPR032660", "IPR032661", "IPR033348", "IPR039092", "IPR040106", "IPR045239", "IPR045896", "IPR047093", "IPR047094", "IPR047206", "IPR047265", "IPR048064", "...

0

26

0

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "metagenomes" ]

[ 2, 22, 262595, 33, 5 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 779, 44, 419, 148, 349, 334, 14, 462, 404, 8, 4, 961 ]

12

true

Domain

Myc-type, basic helix-loop-helix (bHLH) domain

bHLH_dom

3

IPR011599

11,599

Prefoldin alpha subunit, archaea-type

PFD_alpha_archaea

Family

5,257

false

Prefoldin (PFD) is a chaperone that interacts exclusively with type II chaperonins, hetero-oligomers lacking an obligate co-chaperonin that are found only in eukaryotes (chaperonin-containing T-complex polypeptide-1 (CCT)) and archaea. Eukaryotic PFD is a multi-subunit complex containing six polypeptides in the molecul...

[ "GO:0051082", "GO:0006457", "GO:0016272" ]

[ "unfolded protein binding", "protein folding", "prefoldin complex" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "HAMAP", "PANTHER" ]

[ "MF_00308", "PTHR12674" ]

[ "PfdA", "" ]

[ 1489, 5061 ]

2

[ "GP", "REACTOME" ]

[ "GenProp0246", "R-HSA-389957" ]

[ "GP:GenProp0246", "REACTOME:R-HSA-389957" ]

2

[ "1fxk", "2zdi", "6nr8", "6nr9", "6nrb", "6nrc", "6nrd", "6vy1", "7wu7" ]

9

[ "PUB00013187", "PUB00013306" ]

[ "12456645", "11106732" ]

[ "Structure of eukaryotic prefoldin and of its complexes with unfolded actin and the cytosolic chaperonin CCT.", "Structure of the molecular chaperone prefoldin: unique interaction of multiple coiled coil tentacles with unfolded proteins." ]

[ 2002, 2000 ]

2

[ "IPR004127" ]

[]

1

0

1

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 885, 11, 4331, 30 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 2, 2, 2, 2, 3, 7, 1, 6, 6, 2, 1, 4 ]

12

true

Family

Prefoldin alpha subunit, archaea-type

PFD_alpha_archaea

8

IPR011600

11,600

Peptidase C14, caspase domain

Pept_C14_caspase

Domain

58,977

false

This domain can be found in caspases (MEROPS family C12A) and metacaspases (MEROPS family C14B). Metacaspases adopt a caspase fold, with active site loops arranged similarly as other caspases [ ]. Caspases (Cysteine-dependent ASPartyl-specific proteASE) are cysteine peptidases [ ]. They are tightly regulated proteins t...

[ "GO:0004197", "GO:0006508" ]

[ "cysteine-type endopeptidase activity", "proteolysis" ]

[ "molecular_function", "biological_process" ]

2

[ "PFAM" ]

[ "PF00656" ]

[ "Peptidase_C14" ]

[ 58977 ]

1

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", ...

[ "3.4.22", "R-BTA-5620971", "R-CEL-111465", "R-CEL-140342", "R-CEL-198323", "R-CEL-2028269", "R-CEL-264870", "R-CEL-351906", "R-CEL-418889", "R-CEL-5357905", "R-DME-111458", "R-DME-111459", "R-DME-111465", "R-DME-111469", "R-DME-140342", "R-DME-198323", "R-DME-2028269", "R-DME-21439...

[ "EC:3.4.22", "REACTOME:R-BTA-5620971", "REACTOME:R-CEL-111465", "REACTOME:R-CEL-140342", "REACTOME:R-CEL-198323", "REACTOME:R-CEL-2028269", "REACTOME:R-CEL-264870", "REACTOME:R-CEL-351906", "REACTOME:R-CEL-418889", "REACTOME:R-CEL-5357905", "REACTOME:R-DME-111458", "REACTOME:R-DME-111459", "...

153

[ "1bmq", "1cp3", "1f1j", "1f9e", "1gfw", "1gqf", "1i3o", "1i4e", "1i4o", "1i51", "1ibc", "1ice", "1jxq", "1k86", "1k88", "1kmc", "1m72", "1nme", "1nmq", "1nms", "1nw9", "1pau", "1pyo", "1qdu", "1qtn", "1qx3", "1re1", "1rhj", "1rhk", "1rhm", "1rhq", "1rhr"...

358

[ "PUB00011704", "PUB00014747", "PUB00014748", "PUB00015006", "PUB00015008", "PUB00066781", "PUB00066782", "PUB00066783", "PUB00066784", "PUB00066785", "PUB00066787" ]

[ "11517925", "15077141", "15066636", "10578171", "10872455", "22761449", "23522353", "17998208", "18355456", "23506317", "21949125" ]

[ "Evolutionary lines of cysteine peptidases.", "Caspase activation - stepping on the gas or releasing the brakes? Lessons from humans and flies.", "Death without caspases, caspases without death.", "Caspase structure, proteolytic substrates, and function during apoptotic cell death.", "Mammalian caspases: st...

[ 2001, 2004, 2004, 1999, 1999, 2012, 2013, 2008, 2008, 2013, 2011 ]

11

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 61, 16836, 41747, 58, 275 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 35, 6, 62, 12, 62, 42, 4, 30, 54, 1, 1, 54 ]

12

true

Domain

Peptidase C14, caspase domain

Pept_C14_caspase

7

IPR011601

11,601

UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal

MurB_C

Domain

27,731

false

This entry represents a C-terminal conserved region of UDP-N-acetylenolpyruvoylglucosamine reductase , which is also called UDP-N-acetylmuramate dehydrogenase. The C-terminal domain is involved in substrate binding [ ]. It is a part of the pathway for the biosynthesis of the UDP-N-acetylmuramoyl-pentapeptide, which is ...

[ "GO:0008762" ]

[ "UDP-N-acetylmuramate dehydrogenase activity" ]

[ "molecular_function" ]

1

[ "PFAM" ]

[ "PF02873" ]

[ "MurB_C" ]

[ 27731 ]

1

[ "EC", "METACYC", "METACYC", "METACYC" ]

[ "1.3.1.98", "PWY-6386", "PWY-6387", "PWY-7953" ]

[ "EC:1.3.1.98", "METACYC:PWY-6386", "METACYC:PWY-6387", "METACYC:PWY-7953" ]

4

[ "1hsk", "1mbb", "1mbt", "1uxy", "2gqt", "2gqu", "2mbr", "2q85", "3i99", "3tx1", "4jay", "4jb1", "4pyt", "5jzx", "7or2", "7orz", "7osq", "9dtk" ]

18

[ "PUB00037181" ]

[ "8634262" ]

[ "(E)-enolbutyryl-UDP-N-acetylglucosamine as a mechanistic probe of UDP-N-acetylenolpyruvylglucosamine reductase (MurB)." ]

[ 1996 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 10, 26780, 380, 561 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Domain

UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal

MurB_C

4

IPR011602

11,602

Type II pantothenate kinase, bacterial

Type_II_PanK_bac

Family

738

false

Pantothenate kinase (PanK or CoaA) catalyses the first step of the universal five step coenzyme A (CoA) biosynthesis pathway. Three distinct types of pantothenate kinase enzymes have been identified: type I PanK enzymes are typified by the E. coli CoaA protein; type II enzymes are primarily found in eukaryotic organism...

[ "GO:0004594", "GO:0005524", "GO:0015937" ]

[ "pantothenate kinase activity", "ATP binding", "coenzyme A biosynthetic process" ]

[ "molecular_function", "molecular_function", "biological_process" ]

3

[ "HAMAP", "PIRSF" ]

[ "MF_01273", "PIRSF036940" ]

[ "Pantothen_kinase_2", "PanK_bac_aCoA" ]

[ 222, 738 ]

2

[ "EC", "METACYC" ]

[ "2.7.1.33", "PWY-3961" ]

[ "EC:2.7.1.33", "METACYC:PWY-3961" ]

2

[ "2ews", "4m7x", "4m7y", "4nb4", "5elz", "5jic", "6avp", "6awg", "6awh", "6awi", "6awj", "6ebv" ]

12

[ "PUB00067857" ]

[ "8186650" ]

[ "Method for measuring tetraethyl lead and total lead in organic solvents." ]

[ 1994 ]

1

[ "IPR004567" ]

[]

1

0

1

[ "Bacteria", "Eukaryota", "Methanohalarchaeum thermophilum", "ecological metagenomes" ]

[ 729, 3, 1, 5 ]

4

[]

0

true

Family

Type II pantothenate kinase, bacterial

Type_II_PanK_bac

7

IPR011603

11,603

2-oxoglutarate dehydrogenase E1 component

2oxoglutarate_DH_E1

Family

32,830

false

2-oxoglutarate dehydrogenase is a key enzyme in the TCA cycle, converting 2-oxoglutarate, coenzyme A and NAD(+) to succinyl-CoA, NADH and carbon dioxide [ ]. This activity of this enzyme is tightly regulated and it is a major determinant of the metabolic flux through the TCA cycle. This enzyme is composed of multiple c...

[ "GO:0016624", "GO:0030976" ]

[ "oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor", "thiamine pyrophosphate binding" ]

[ "molecular_function", "molecular_function" ]

2

[ "PIRSF", "PANTHER", "NCBIFAM" ]

[ "PIRSF000157", "PTHR23152", "TIGR00239" ]

[ "Oxoglu_dh_E1", "", "2oxo_dh_E1" ]

[ 27978, 32827, 28373 ]

3

[ "EC", "GP", "GP", "GP", "GP", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME",...

[ "1.2.4.2", "GenProp0630", "GenProp1348", "GenProp1487", "GenProp1693", "PWY-5084", "R-BTA-6783984", "R-BTA-9837999", "R-BTA-9853506", "R-CEL-6783984", "R-CEL-9837999", "R-CEL-9853506", "R-CEL-9858328", "R-DDI-6783984", "R-DDI-9837999", "R-DDI-9853506", "R-DDI-9858328", "R-DME-98583...

[ "EC:1.2.4.2", "GP:GenProp0630", "GP:GenProp1348", "GP:GenProp1487", "GP:GenProp1693", "METACYC:PWY-5084", "REACTOME:R-BTA-6783984", "REACTOME:R-BTA-9837999", "REACTOME:R-BTA-9853506", "REACTOME:R-CEL-6783984", "REACTOME:R-CEL-9837999", "REACTOME:R-CEL-9853506", "REACTOME:R-CEL-9858328", "R...

37

[ "2jgd", "2xt6", "2xta", "2y0p", "2yic", "2yid", "3zhq", "3zhr", "3zhs", "3zht", "3zhu", "3zhv", "5rvw", "5rvx", "5rvy", "5rvz", "5rw0", "5rw1", "6i2q", "6i2r", "6i2s", "6km9", "6kma", "6r29", "6r2a", "6r2b", "6r2c", "6r2d", "6sy1", "6u3j", "6vef", "7wgr"...

40

[ "PUB00033922", "PUB00033923" ]

[ "16321804", "9278141" ]

[ "Alpha-ketoglutarate dehydrogenase: a target and generator of oxidative stress.", "2-Oxo acid dehydrogenase multienzyme complexes. The central role of the lipoyl domain." ]

[ 2005, 1997 ]

2

[]

[ "IPR023784" ]

0

1

0

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 19174, 13185, 471 ]

3

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus",...

[ 13, 4, 17, 11, 1, 18, 7, 1, 8, 16, 1, 1, 57 ]

13

true

Family

2-oxoglutarate dehydrogenase E1 component

2oxoglutarate_DH_E1

4

IPR011604

11,604

PD-(D/E)XK endonuclease-like domain superfamily

PDDEXK-like_dom_sf

Homologous_superfamily

102,463

false

This entry represent a PD-(D/E)XK endonuclease-like domain superfamily [ ]. PD-(D/E)XK nucleases constitute a large and highly diverse superfamily of enzymes that display little sequence similarity. However, they share a common core fold and a few critical active site residues [ ]. This domain can be found at the C ter...

[]

0

[ "CATHGENE3D" ]

[ "G3DSA:3.90.320.10" ]

[ "" ]

[ 102463 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-174437", "R-BTA-5685938", "R-BTA-5685942", "R-BTA-5693568", "R-BTA-5693579", "R-BTA-5693607", "R-BTA-5693616", "R-BTA-6804756", "R-BTA-69166", "R-BTA-69473", "R-GGA-5685938", "R-GGA-5685942", "R-GGA-5693568", "R-GGA-5693579", "R-GGA-5693607", "R-GGA-5693616", "R-HSA-174437", ...

[ "REACTOME:R-BTA-174437", "REACTOME:R-BTA-5685938", "REACTOME:R-BTA-5685942", "REACTOME:R-BTA-5693568", "REACTOME:R-BTA-5693579", "REACTOME:R-BTA-5693607", "REACTOME:R-BTA-5693616", "REACTOME:R-BTA-6804756", "REACTOME:R-BTA-69166", "REACTOME:R-BTA-69473", "REACTOME:R-GGA-5685938", "REACTOME:R-G...

56

[ "1avq", "1w36", "3h4r", "3k70", "3k93", "3l0a", "3slp", "3sm4", "3syy", "3sz4", "3sz5", "3u44", "3u4q", "4ceh", "4cei", "4cej", "4ic1", "4r5q", "4wuz", "5ean", "5eaw", "5eax", "5ld2", "5mbv", "5yet", "5yeu", "5zyt", "5zyu", "5zyv", "5zyw", "6m9k", "6ppj"...

62

[ "PUB00020736", "PUB00028199", "PUB00033616", "PUB00044133", "PUB00088340", "PUB00088341", "PUB00153687" ]

[ "15972856", "9295273", "15538360", "17584917", "17570399", "10617645", "15256582" ]

[ "Identification of novel restriction endonuclease-like fold families among hypothetical proteins.", "Toroidal structure of lambda-exonuclease.", "Crystal structure of RecBCD enzyme reveals a machine for processing DNA breaks.", "Realm of PD-(D/E)XK nuclease superfamily revisited: detection of novel families w...

[ 2005, 1997, 2004, 2007, 2007, 2000, 2004 ]

7

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 3001, 75104, 16782, 4383, 3193 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus",...

[ 17, 2, 11, 5, 3, 10, 4, 3, 10, 10, 1, 1, 23 ]

13

true

Homologous_superfamily

PD-(D/E)XK endonuclease-like domain superfamily

PDDEXK-like_dom_sf

7

IPR011605

11,605

NusB antitermination factor

NusB_fam

Family

25,432

false

The NusB protein is involved in the regulation of rRNA biosynthesis by transcriptional antitermination. The antitermination proteins of Escherichia coli are recruited in the replication cycle of Bacteriophage lambda, where they play an important role in switching from the lysogenic to the lytic cycle. The solution stru...

[ "GO:0006353" ]

[ "DNA-templated transcription termination" ]

[ "biological_process" ]

1

[ "HAMAP", "PANTHER", "NCBIFAM" ]

[ "MF_00073", "PTHR11078", "TIGR01951" ]

[ "NusB", "", "nusB" ]

[ 21500, 25110, 24276 ]

3

[ "GP" ]

[ "GenProp0132" ]

[ "GP:GenProp0132" ]

1

[ "1ey1", "1eyv", "1tzt", "1tzu", "1tzv", "1tzw", "1tzx", "2jr0", "3d3b", "3d3c", "3imq", "3r2c", "3r2d", "4eya", "5lm7", "5ms0", "6ckq", "6gov", "6tqn", "6tqo" ]

20

[ "PUB00001316" ]

[ "9670024" ]

[ "Solution structure of the antitermination protein NusB of Escherichia coli: a novel all-helical fold for an RNA-binding protein." ]

[ 1998 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "candidate division MSBL1 archaeon SCGC-AAA382N08", "unclassified sequences" ]

[ 24230, 659, 1, 542 ]

4

[ "Arabidopsis thaliana", "Escherichia coli (strain K12)", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 5, 1, 4, 14 ]

4

true

Family

NusB antitermination factor

NusB_fam

5

IPR011606

11,606

Branched-chain amino acid transport, permease

Brnchd-chn_aa_trnsp_permease

Family

21,434

false

This entry includes some uncharacterised bacterial proteins and the branched-chain amino acid transport protein AzlC encoded by azlC gene, which is part of the azl operon, involved in branched-chain amino acid transport [ ]. AzlCD is a bipartite histidine exporter consisting of AzlC and AzlD subunits [ ]. Overexpressio...

[]

0

[ "PANTHER" ]

[ "PTHR34979" ]

[ "" ]

[ 21434 ]

1

[]

0

[]

0

[ "PUB00011254", "PUB00152867" ]

[ "9287000", "36377869" ]

[ "An lrp-like gene of Bacillus subtilis involved in branched-chain amino acid transport.", "How To Deal with Toxic Amino Acids: the Bipartite AzlCD Complex Exports Histidine in <i>Bacillus subtilis</i>." ]

[ 1997, 2022 ]

2

[]

[ "IPR004471" ]

0

1

0

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 436, 20718, 10, 270 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Branched-chain amino acid transport, permease

Brnchd-chn_aa_trnsp_permease

9

IPR011607

11,607

Methylglyoxal synthase-like domain

MGS-like_dom

Domain

72,569

false

Methylglyoxal synthase (MGS, ), which catalyses the conversion of dihydroxyacetone phosphate (DHAP) to methylglyoxal (MG) and inorganic phosphate, has been found in many organisms, including enteric bacteria, some gram-positive bacteria, a number of archaebacteria, several yeast species and goat liver [ , ]. The main c...

[]

0

[ "PFAM", "PROFILE", "SMART" ]

[ "PF02142", "PS51855", "SM00851" ]

[ "MGS", "MGS", "MGS" ]

[ 69763, 72252, 69617 ]

3

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-73817", "R-CEL-500753", "R-DDI-500753", "R-DDI-73817", "R-DME-500753", "R-GGA-419140", "R-HSA-500753", "R-HSA-70635", "R-HSA-73817", "R-HSA-9725370", "R-MMU-500753", "R-MMU-70635", "R-MMU-73817", "R-RNO-70635", "R-RNO-73817", "R-SCE-500753", "R-SCE-70635", "R-SCE-73817", "...

[ "REACTOME:R-BTA-73817", "REACTOME:R-CEL-500753", "REACTOME:R-DDI-500753", "REACTOME:R-DDI-73817", "REACTOME:R-DME-500753", "REACTOME:R-GGA-419140", "REACTOME:R-HSA-500753", "REACTOME:R-HSA-70635", "REACTOME:R-HSA-73817", "REACTOME:R-HSA-9725370", "REACTOME:R-MMU-500753", "REACTOME:R-MMU-70635"...

21

[ "1a9x", "1b93", "1bxr", "1c30", "1c3o", "1ce8", "1cs0", "1egh", "1g8m", "1ik4", "1jdb", "1kee", "1m6v", "1m9n", "1oz0", "1p4r", "1pkx", "1pl0", "1s89", "1s8a", "1t36", "1thz", "1vmd", "1wo8", "1zcz", "2b1g", "2b1i", "2iu0", "2iu3", "2x8w", "2xw6", "2yvq"...

48

[ "PUB00007868", "PUB00015023", "PUB00022443", "PUB00094782", "PUB00094783", "PUB00094784" ]

[ "10089390", "10526357", "14756553", "23592737", "29063699", "10388730" ]

[ "The structure of carbamoyl phosphate synthetase determined to 2.1 A resolution.", "Structure classification-based assessment of CASP3 predictions for the fold recognition targets.", "Structural insights into the human and avian IMP cyclohydrolase mechanism via crystal structures with the bound XMP inhibitor.",...

[ 1999, 1999, 2004, 2013, 2017, 1999 ]

6

[]

[ "IPR033937" ]

0

1

0

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 991, 57264, 13005, 10, 1299 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus",...

[ 11, 2, 6, 4, 3, 15, 8, 3, 6, 15, 4, 3, 17 ]

13

true

Domain

Methylglyoxal synthase-like domain

MGS-like_dom

1

IPR011608

11,608

PRD domain

PRD

Domain

32,555

false

Transcriptional antiterminators and activators containing phosphoenolpyruvate: sugar phosphotransferase system (PTS) regulation domains (PRDs) form a class of bacterial regulatory proteins whose activity is modulated by phosphorylation. These regulators stimulate the expression of genes and operons involved in carbohyd...

[ "GO:0006355" ]

[ "regulation of DNA-templated transcription" ]

[ "biological_process" ]

1

[ "PFAM", "PROFILE" ]

[ "PF00874", "PS51372" ]

[ "PRD", "PRD_2" ]

[ 30561, 32422 ]

2

[]

0

[ "1h99", "1tlv", "3gwh", "3nuf", "3rio", "3ufe", "4r6i", "6twr", "9atx" ]

9

[ "PUB00002205", "PUB00002306", "PUB00015024", "PUB00015025", "PUB00015026", "PUB00031497", "PUB00043695", "PUB00043696" ]

[ "1732212", "9045813", "11751049", "11733988", "11447120", "15699035", "9202047", "9663674" ]

[ "Nucleotide sequences of the arb genes, which control beta-glucoside utilization in Erwinia chrysanthemi: comparison with the Escherichia coli bgl operon and evidence for a new beta-glycohydrolase family including enzymes from eubacteria, archeabacteria, and humans.", "The lac operon of Lactobacillus casei contai...

[ 1992, 1997, 2001, 2001, 2001, 2005, 1997, 1998 ]

8

[]

0

null

[ "Bacteria", "Eukaryota", "Methanothermobacter tenebrarum", "metagenomes" ]

[ 32437, 34, 1, 83 ]

4

[ "Escherichia coli (strain K12)" ]

[ 3 ]

1

true

Domain

PRD domain

PRD

6

IPR011610

11,610

S-adenosyl-L-methionine-dependent methyltransferase ML2640-like

SAM_mthyl_Trfase_ML2640-like

Family

11,365

false

This family represents a set of probable methyltransferases, including ML2640 from Mycobacterium leprae, which has SAM-methyltransferase activity [ ].

[ "GO:0008168" ]

[ "methyltransferase activity" ]

[ "molecular_function" ]

1

[ "NCBIFAM" ]

[ "TIGR00027" ]

[ "mthyl_TIGR00027" ]

[ 11365 ]

1

[ "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC"...

[ "2.1.1.-", "PWY-1061", "PWY-2083", "PWY-3542", "PWY-4021", "PWY-4161", "PWY-4202", "PWY-5059", "PWY-5105", "PWY-5301", "PWY-5305", "PWY-5479", "PWY-5665", "PWY-5729", "PWY-5748", "PWY-5765", "PWY-5773", "PWY-5846", "PWY-5883", "PWY-5975", "PWY-5987", "PWY-601", "PWY-6045"...

[ "EC:2.1.1.-", "METACYC:PWY-1061", "METACYC:PWY-2083", "METACYC:PWY-3542", "METACYC:PWY-4021", "METACYC:PWY-4161", "METACYC:PWY-4202", "METACYC:PWY-5059", "METACYC:PWY-5105", "METACYC:PWY-5301", "METACYC:PWY-5305", "METACYC:PWY-5479", "METACYC:PWY-5665", "METACYC:PWY-5729", "METACYC:PWY-5...

146

[ "2ckd", "2uyo", "2uyq", "6id6" ]

4

[ "PUB00047192" ]

[ "17660248" ]

[ "The crystal structure of M. leprae ML2640c defines a large family of putative S-adenosylmethionine-dependent methyltransferases in mycobacteria." ]

[ 2007 ]

1

[ "IPR007213" ]

[]

1

0

1

[ "Bacteria", "Eukaryota", "Methanobacteriota", "unclassified sequences" ]

[ 10212, 1006, 93, 54 ]

4

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 5, 2, 2 ]

3

true

Family

S-adenosyl-L-methionine-dependent methyltransferase ML2640-like

SAM_mthyl_Trfase_ML2640-like

8