MaIlz/replace_102 · Datasets at Hugging Face

prompt stringlengths 120 209	completion stringlengths 15 103	input_smiles stringlengths 14 103	output_smiles stringlengths 15 103	task_id int64 102 102	winner_action dict
Can you make molecule CC(C)(C)c1ccc2occ(CC(=O)Nc3ccccc3F)c2c1 less soluble in water? The output molecule should be similar to the input molecule.	CC(C)(C)c1ccc2occ(CCC(CO)=Nc3ccccc3F)c2c1	CC(C)(C)c1ccc2occ(CC(=O)Nc3ccccc3F)c2c1	CC(C)(C)c1ccc2occ(CCC(CO)=Nc3ccccc3F)c2c1	102	{ "fragment_index": 0, "new_substring": "C&CC=&CO", "old_substring": "C7C4=O" }
Can you make molecule CC(C)(C)c1ccc2occ(CC(=O)Nc3ccccc3F)c2c1 less soluble in water? The output molecule should be similar to the input molecule.	C/C(Cc1coc2ccc(C(C)(C)C)cc12)=N/ONc1ccccc1F	CC(C)(C)c1ccc2occ(CC(=O)Nc3ccccc3F)c2c1	C/C(Cc1coc2ccc(C(C)(C)C)cc12)=N/ONc1ccccc1F	102	{ "fragment_index": 0, "new_substring": "C/C(C&)=N/O&", "old_substring": "C7C4=O" }
Can you make molecule CC(C)(C)c1ccc2occ(CC(=O)Nc3ccccc3F)c2c1 less soluble in water? The output molecule should be similar to the input molecule.	CCC(CC)(C(=O)CNc1ccccc1F)c1coc2ccc(C(C)(C)C)cc12	CC(C)(C)c1ccc2occ(CC(=O)Nc3ccccc3F)c2c1	CCC(CC)(C(=O)CNc1ccccc1F)c1coc2ccc(C(C)(C)C)cc12	102	{ "fragment_index": 0, "new_substring": "CCC&(CC)C(=O)C&", "old_substring": "C7C4=O" }
Can you make molecule CC(C)(C)c1ccc2occ(CC(=O)Nc3ccccc3F)c2c1 less soluble in water? The output molecule should be similar to the input molecule.	CC(C)(C)c1ccc2occ(SSC(=O)Nc3ccccc3F)c2c1	CC(C)(C)c1ccc2occ(CC(=O)Nc3ccccc3F)c2c1	CC(C)(C)c1ccc2occ(SSC(=O)Nc3ccccc3F)c2c1	102	{ "fragment_index": 0, "new_substring": "S&SC&=O", "old_substring": "C7C4=O" }
Can you make molecule CC(C)(C)c1ccc2occ(CC(=O)Nc3ccccc3F)c2c1 less soluble in water? The output molecule should be similar to the input molecule.	CCC(CC)(C(=O)CCNc1ccccc1F)c1coc2ccc(C(C)(C)C)cc12	CC(C)(C)c1ccc2occ(CC(=O)Nc3ccccc3F)c2c1	CCC(CC)(C(=O)CCNc1ccccc1F)c1coc2ccc(C(C)(C)C)cc12	102	{ "fragment_index": 0, "new_substring": "CCC&(CC)C(=O)CC&", "old_substring": "C7C4=O" }
Can you make molecule C[C@@H]1CC(Nc2cncc(-c3nncn3C)c2)C[C@@H](C)C1 less soluble in water? The output molecule should be similar to the input molecule.	Cc1nnsc1-c1cncc(NC2C[C@@H](C)C[C@H](C)C2)c1	C[C@@H]1CC(Nc2cncc(-c3nncn3C)c2)C[C@@H](C)C1	Cc1nnsc1-c1cncc(NC2C[C@@H](C)C[C@H](C)C2)c1	102	{ "fragment_index": 0, "new_substring": "c1&snnc1C", "old_substring": "c16nncn1C" }
Can you make molecule C[C@@H]1CC(Nc2cncc(-c3nncn3C)c2)C[C@@H](C)C1 less soluble in water? The output molecule should be similar to the input molecule.	Cc1nonc1-c1cncc(NC2C[C@@H](C)C[C@H](C)C2)c1	C[C@@H]1CC(Nc2cncc(-c3nncn3C)c2)C[C@@H](C)C1	Cc1nonc1-c1cncc(NC2C[C@@H](C)C[C@H](C)C2)c1	102	{ "fragment_index": 0, "new_substring": "c1&nonc1C", "old_substring": "c16nncn1C" }
Can you make molecule C[C@@H]1CC(Nc2cncc(-c3nncn3C)c2)C[C@@H](C)C1 less soluble in water? The output molecule should be similar to the input molecule.	C[C@@H]1CC(Nc2cncc(-c3nnsc3Cl)c2)C[C@@H](C)C1	C[C@@H]1CC(Nc2cncc(-c3nncn3C)c2)C[C@@H](C)C1	C[C@@H]1CC(Nc2cncc(-c3nnsc3Cl)c2)C[C@@H](C)C1	102	{ "fragment_index": 0, "new_substring": "c1&nnsc1Cl", "old_substring": "c16nncn1C" }
Can you make molecule C[C@@H]1CC(Nc2cncc(-c3nncn3C)c2)C[C@@H](C)C1 less soluble in water? The output molecule should be similar to the input molecule.	C[C@@H]1CC(Nc2cncc(-c3nsnc3Cl)c2)C[C@@H](C)C1	C[C@@H]1CC(Nc2cncc(-c3nncn3C)c2)C[C@@H](C)C1	C[C@@H]1CC(Nc2cncc(-c3nsnc3Cl)c2)C[C@@H](C)C1	102	{ "fragment_index": 0, "new_substring": "c1&nsnc1Cl", "old_substring": "c16nncn1C" }
Can you make molecule C[C@@H]1CC(Nc2cncc(-c3nncn3C)c2)C[C@@H](C)C1 less soluble in water? The output molecule should be similar to the input molecule.	C[C@@H]1CC(Nc2cncc(-c3nnc4n3CCCS4)c2)C[C@@H](C)C1	C[C@@H]1CC(Nc2cncc(-c3nncn3C)c2)C[C@@H](C)C1	C[C@@H]1CC(Nc2cncc(-c3nnc4n3CCCS4)c2)C[C@@H](C)C1	102	{ "fragment_index": 0, "new_substring": "c1&nnc2n1CCCS2", "old_substring": "c16nncn1C" }
Can you make molecule N#Cc1ccc(-c2ccc(O[C@@H](C(=O)N3CCCC3)c3ccccc3)cc2)cc1 less soluble in water? The output molecule should be similar to the input molecule.	N#Cc1ccc(-c2ccc(O[C@@H]3C[C@](c4ccccc4)(N4CCCC4)CCO3)cc2)cc1	N#Cc1ccc(-c2ccc(O[C@@H](C(=O)N3CCCC3)c3ccccc3)cc2)cc1	N#Cc1ccc(-c2ccc(O[C@@H]3C[C@](c4ccccc4)(N4CCCC4)CCO3)cc2)cc1	102	{ "fragment_index": 0, "new_substring": "[C@@H]1&C[C@]&&CCO1", "old_substring": "[C@@H]57C4=O" }
Can you make molecule N#Cc1ccc(-c2ccc(O[C@@H](C(=O)N3CCCC3)c3ccccc3)cc2)cc1 less soluble in water? The output molecule should be similar to the input molecule.	N#Cc1ccc(-c2ccc(O[C@@H]3CCC[C@](c4ccccc4)(N4CCCC4)C3)cc2)cc1	N#Cc1ccc(-c2ccc(O[C@@H](C(=O)N3CCCC3)c3ccccc3)cc2)cc1	N#Cc1ccc(-c2ccc(O[C@@H]3CCC[C@](c4ccccc4)(N4CCCC4)C3)cc2)cc1	102	{ "fragment_index": 0, "new_substring": "[C@@H]1&CCC[C@]&&C1", "old_substring": "[C@@H]57C4=O" }
Can you make molecule N#Cc1ccc(-c2ccc(O[C@@H](C(=O)N3CCCC3)c3ccccc3)cc2)cc1 less soluble in water? The output molecule should be similar to the input molecule.	N#Cc1ccc(-c2ccc(O[C@@H]3CC[C@H](c4ccccc4)N3N3CCCC3)cc2)cc1	N#Cc1ccc(-c2ccc(O[C@@H](C(=O)N3CCCC3)c3ccccc3)cc2)cc1	N#Cc1ccc(-c2ccc(O[C@@H]3CC[C@H](c4ccccc4)N3N3CCCC3)cc2)cc1	102	{ "fragment_index": 0, "new_substring": "[C@@H]1&CC[C@H]&N1&", "old_substring": "[C@@H]57C4=O" }
Can you make molecule N#Cc1ccc(-c2ccc(O[C@@H](C(=O)N3CCCC3)c3ccccc3)cc2)cc1 less soluble in water? The output molecule should be similar to the input molecule.	N#Cc1ccc(-c2ccc(OCC[C@H](Cc3ccccc3)C(=O)N3CCCC3)cc2)cc1	N#Cc1ccc(-c2ccc(O[C@@H](C(=O)N3CCCC3)c3ccccc3)cc2)cc1	N#Cc1ccc(-c2ccc(OCC[C@H](Cc3ccccc3)C(=O)N3CCCC3)cc2)cc1	102	{ "fragment_index": 0, "new_substring": "C&C[C@H](C&)C&=O", "old_substring": "[C@@H]57C4=O" }
Can you make molecule N#Cc1ccc(-c2ccc(O[C@@H](C(=O)N3CCCC3)c3ccccc3)cc2)cc1 less soluble in water? The output molecule should be similar to the input molecule.	N#Cc1ccc(-c2ccc(O[C@H]3CC[C@](c4ccccc4)(N4CCCC4)C3)cc2)cc1	N#Cc1ccc(-c2ccc(O[C@@H](C(=O)N3CCCC3)c3ccccc3)cc2)cc1	N#Cc1ccc(-c2ccc(O[C@H]3CC[C@](c4ccccc4)(N4CCCC4)C3)cc2)cc1	102	{ "fragment_index": 0, "new_substring": "[C@H]1&CC[C@]&&C1", "old_substring": "[C@@H]57C4=O" }
Can you make molecule CCOC(=O)[C@@H]1CCCN(C(=O)c2nc(-c3ccc(C)cc3)n3c2CCCCC3)C1 less soluble in water? The output molecule should be similar to the input molecule.	CCOC(=O)[C@@H]1N=NC=C1CCC(=O)c1nc(-c2ccc(C)cc2)n2c1CCCCC2	CCOC(=O)[C@@H]1CCCN(C(=O)c2nc(-c3ccc(C)cc3)n3c2CCCCC3)C1	CCOC(=O)[C@@H]1N=NC=C1CCC(=O)c1nc(-c2ccc(C)cc2)n2c1CCCCC2	102	{ "fragment_index": 0, "new_substring": "[C@@H]1&N=NC=C1CC&", "old_substring": "[C@@H]18CCCN5C1" }
Can you make molecule CCOC(=O)[C@@H]1CCCN(C(=O)c2nc(-c3ccc(C)cc3)n3c2CCCCC3)C1 less soluble in water? The output molecule should be similar to the input molecule.	CCOC(=O)[C@@H]1CC[C@@H](C(=O)c2nc(-c3ccc(C)cc3)n3c2CCCCC3)C1	CCOC(=O)[C@@H]1CCCN(C(=O)c2nc(-c3ccc(C)cc3)n3c2CCCCC3)C1	CCOC(=O)[C@@H]1CC[C@@H](C(=O)c2nc(-c3ccc(C)cc3)n3c2CCCCC3)C1	102	{ "fragment_index": 0, "new_substring": "[C@@H]1&CC[C@@H]&C1", "old_substring": "[C@@H]18CCCN5C1" }
Can you make molecule CCOC(=O)[C@@H]1CCCN(C(=O)c2nc(-c3ccc(C)cc3)n3c2CCCCC3)C1 less soluble in water? The output molecule should be similar to the input molecule.	CCOC(=O)[C@H]1C(CC(=O)c2nc(-c3ccc(C)cc3)n3c2CCCCC3)=CN=C1C	CCOC(=O)[C@@H]1CCCN(C(=O)c2nc(-c3ccc(C)cc3)n3c2CCCCC3)C1	CCOC(=O)[C@H]1C(CC(=O)c2nc(-c3ccc(C)cc3)n3c2CCCCC3)=CN=C1C	102	{ "fragment_index": 0, "new_substring": "[C@H]1&C(C&)=CN=C1C", "old_substring": "[C@@H]18CCCN5C1" }
Can you make molecule CCOC(=O)[C@@H]1CCCN(C(=O)c2nc(-c3ccc(C)cc3)n3c2CCCCC3)C1 less soluble in water? The output molecule should be similar to the input molecule.	CCOC(=O)[C@H](CCl)CCCC(=O)c1nc(-c2ccc(C)cc2)n2c1CCCCC2	CCOC(=O)[C@@H]1CCCN(C(=O)c2nc(-c3ccc(C)cc3)n3c2CCCCC3)C1	CCOC(=O)[C@H](CCl)CCCC(=O)c1nc(-c2ccc(C)cc2)n2c1CCCCC2	102	{ "fragment_index": 0, "new_substring": "[C@@H]&(CCl)CCC&", "old_substring": "[C@@H]18CCCN5C1" }
Can you make molecule CCOC(=O)[C@@H]1CCCN(C(=O)c2nc(-c3ccc(C)cc3)n3c2CCCCC3)C1 less soluble in water? The output molecule should be similar to the input molecule.	CCOC(=O)[C@H]1C=C[C@H](C(=O)c2nc(-c3ccc(C)cc3)n3c2CCCCC3)C1	CCOC(=O)[C@@H]1CCCN(C(=O)c2nc(-c3ccc(C)cc3)n3c2CCCCC3)C1	CCOC(=O)[C@H]1C=C[C@H](C(=O)c2nc(-c3ccc(C)cc3)n3c2CCCCC3)C1	102	{ "fragment_index": 0, "new_substring": "[C@H]1&C=C[C@H]&C1", "old_substring": "[C@@H]18CCCN5C1" }
Can you make molecule N#CC1=C(SCC(=O)Nc2cccc(Cl)c2)N=C([O-])[C@H](C#N)C12CCCCC2 less soluble in water? The output molecule should be similar to the input molecule.	N#CC1=C(SCCC(CO)=Nc2cccc(Cl)c2)N=C([O-])[C@H](C#N)C12CCCCC2	N#CC1=C(SCC(=O)Nc2cccc(Cl)c2)N=C([O-])[C@H](C#N)C12CCCCC2	N#CC1=C(SCCC(CO)=Nc2cccc(Cl)c2)N=C([O-])[C@H](C#N)C12CCCCC2	102	{ "fragment_index": 0, "new_substring": "C&CC=&CO", "old_substring": "C4C3=O" }
Can you make molecule N#CC1=C(SCC(=O)Nc2cccc(Cl)c2)N=C([O-])[C@H](C#N)C12CCCCC2 less soluble in water? The output molecule should be similar to the input molecule.	C/C(CSC1=C(C#N)C2(CCCCC2)[C@@H](C#N)C([O-])=N1)=N/ONc1cccc(Cl)c1	N#CC1=C(SCC(=O)Nc2cccc(Cl)c2)N=C([O-])[C@H](C#N)C12CCCCC2	C/C(CSC1=C(C#N)C2(CCCCC2)[C@@H](C#N)C([O-])=N1)=N/ONc1cccc(Cl)c1	102	{ "fragment_index": 0, "new_substring": "C/C(C&)=N/O&", "old_substring": "C4C3=O" }
Can you make molecule N#CC1=C(SCC(=O)Nc2cccc(Cl)c2)N=C([O-])[C@H](C#N)C12CCCCC2 less soluble in water? The output molecule should be similar to the input molecule.	CCC(CC)(SC1=C(C#N)C2(CCCCC2)[C@@H](C#N)C([O-])=N1)C(=O)CNc1cccc(Cl)c1	N#CC1=C(SCC(=O)Nc2cccc(Cl)c2)N=C([O-])[C@H](C#N)C12CCCCC2	CCC(CC)(SC1=C(C#N)C2(CCCCC2)[C@@H](C#N)C([O-])=N1)C(=O)CNc1cccc(Cl)c1	102	{ "fragment_index": 0, "new_substring": "CCC&(CC)C(=O)C&", "old_substring": "C4C3=O" }
Can you make molecule N#CC1=C(SCC(=O)Nc2cccc(Cl)c2)N=C([O-])[C@H](C#N)C12CCCCC2 less soluble in water? The output molecule should be similar to the input molecule.	N#CC1=C(SSSC(=O)Nc2cccc(Cl)c2)N=C([O-])[C@H](C#N)C12CCCCC2	N#CC1=C(SCC(=O)Nc2cccc(Cl)c2)N=C([O-])[C@H](C#N)C12CCCCC2	N#CC1=C(SSSC(=O)Nc2cccc(Cl)c2)N=C([O-])[C@H](C#N)C12CCCCC2	102	{ "fragment_index": 0, "new_substring": "S&SC&=O", "old_substring": "C4C3=O" }
Can you make molecule N#CC1=C(SCC(=O)Nc2cccc(Cl)c2)N=C([O-])[C@H](C#N)C12CCCCC2 less soluble in water? The output molecule should be similar to the input molecule.	CCC(CC)(SC1=C(C#N)C2(CCCCC2)[C@@H](C#N)C([O-])=N1)C(=O)CCNc1cccc(Cl)c1	N#CC1=C(SCC(=O)Nc2cccc(Cl)c2)N=C([O-])[C@H](C#N)C12CCCCC2	CCC(CC)(SC1=C(C#N)C2(CCCCC2)[C@@H](C#N)C([O-])=N1)C(=O)CCNc1cccc(Cl)c1	102	{ "fragment_index": 0, "new_substring": "CCC&(CC)C(=O)CC&", "old_substring": "C4C3=O" }
Can you make molecule CC[NH+](CC)[C@](C)(CC)[C@H](O)c1cscc1Br less soluble in water? The output molecule should be similar to the input molecule.	CC[NH+](C1(C)Cc2ccccc2C1)[C@](C)(CC)[C@H](O)c1cscc1Br	CC[NH+](CC)[C@](C)(CC)[C@H](O)c1cscc1Br	CC[NH+](C1(C)Cc2ccccc2C1)[C@](C)(CC)[C@H](O)c1cscc1Br	102	{ "fragment_index": 0, "new_substring": "CC1&Cc2ccccc2C1", "old_substring": "CC2" }
Can you make molecule CC[NH+](CC)[C@](C)(CC)[C@H](O)c1cscc1Br less soluble in water? The output molecule should be similar to the input molecule.	CC[NH+](C1=CC2=CC=C2OC(C)(C)C1)[C@](C)(CC)[C@H](O)c1cscc1Br	CC[NH+](CC)[C@](C)(CC)[C@H](O)c1cscc1Br	CC[NH+](C1=CC2=CC=C2OC(C)(C)C1)[C@](C)(CC)[C@H](O)c1cscc1Br	102	{ "fragment_index": 0, "new_substring": "CC1(C)Cc2cc&ccc2O1", "old_substring": "CC2" }
Can you make molecule CC[NH+](CC)[C@](C)(CC)[C@H](O)c1cscc1Br less soluble in water? The output molecule should be similar to the input molecule.	CC[NH+](N1CC(C)(C)Oc2ccccc21)[C@](C)(CC)[C@H](O)c1cscc1Br	CC[NH+](CC)[C@](C)(CC)[C@H](O)c1cscc1Br	CC[NH+](N1CC(C)(C)Oc2ccccc21)[C@](C)(CC)[C@H](O)c1cscc1Br	102	{ "fragment_index": 0, "new_substring": "CC1(C)CN&c2ccccc2O1", "old_substring": "CC2" }
Can you make molecule CC[NH+](CC)[C@](C)(CC)[C@H](O)c1cscc1Br less soluble in water? The output molecule should be similar to the input molecule.	CC[NH+](N1CC(C)(C)Sc2ccccc21)[C@](C)(CC)[C@H](O)c1cscc1Br	CC[NH+](CC)[C@](C)(CC)[C@H](O)c1cscc1Br	CC[NH+](N1CC(C)(C)Sc2ccccc21)[C@](C)(CC)[C@H](O)c1cscc1Br	102	{ "fragment_index": 0, "new_substring": "CC1(C)CN&c2ccccc2S1", "old_substring": "CC2" }
Can you make molecule CC[NH+](CC)[C@](C)(CC)[C@H](O)c1cscc1Br less soluble in water? The output molecule should be similar to the input molecule.	CC[NH+](C1C2CCC1CC2)[C@](C)(CC)[C@H](O)c1cscc1Br	CC[NH+](CC)[C@](C)(CC)[C@H](O)c1cscc1Br	CC[NH+](C1C2CCC1CC2)[C@](C)(CC)[C@H](O)c1cscc1Br	102	{ "fragment_index": 0, "new_substring": "C1&C2CCC1CC2", "old_substring": "CC2" }
Can you make molecule COc1ccc(C(=O)N(C)[C@@H](C)C/C(N)=N/O)cc1O less soluble in water? The output molecule should be similar to the input molecule.	COc1ccc(C(=O)c2nc(C#N)c([C@@H](C)C/C(N)=N/O)o2)cc1O	COc1ccc(C(=O)N(C)[C@@H](C)C/C(N)=N/O)cc1O	COc1ccc(C(=O)c2nc(C#N)c([C@@H](C)C/C(N)=N/O)o2)cc1O	102	{ "fragment_index": 0, "new_substring": "N#Cc1nc&oc1&", "old_substring": "N24C" }
Can you make molecule COc1ccc(C(=O)N(C)[C@@H](C)C/C(N)=N/O)cc1O less soluble in water? The output molecule should be similar to the input molecule.	COc1ccc(C(=O)c2cc(C#N)c([C@@H](C)C/C(N)=N/O)s2)cc1O	COc1ccc(C(=O)N(C)[C@@H](C)C/C(N)=N/O)cc1O	COc1ccc(C(=O)c2cc(C#N)c([C@@H](C)C/C(N)=N/O)s2)cc1O	102	{ "fragment_index": 0, "new_substring": "N#Cc1cc&sc1&", "old_substring": "N24C" }
Can you make molecule COc1ccc(C(=O)N(C)[C@@H](C)C/C(N)=N/O)cc1O less soluble in water? The output molecule should be similar to the input molecule.	COc1ccc(C(=O)c2ccc([C@@H](C)C/C(N)=N/O)c(C#N)c2)cc1O	COc1ccc(C(=O)N(C)[C@@H](C)C/C(N)=N/O)cc1O	COc1ccc(C(=O)c2ccc([C@@H](C)C/C(N)=N/O)c(C#N)c2)cc1O	102	{ "fragment_index": 0, "new_substring": "N#Cc1cc&ccc1&", "old_substring": "N24C" }
Can you make molecule COc1ccc(C(=O)N(C)[C@@H](C)C/C(N)=N/O)cc1O less soluble in water? The output molecule should be similar to the input molecule.	COc1ccc(C(=O)ON=C2CCN([C@@H](C)C/C(N)=N/O)CC2)cc1O	COc1ccc(C(=O)N(C)[C@@H](C)C/C(N)=N/O)cc1O	COc1ccc(C(=O)ON=C2CCN([C@@H](C)C/C(N)=N/O)CC2)cc1O	102	{ "fragment_index": 0, "new_substring": "O&N=C1CCN&CC1", "old_substring": "N24C" }
Can you make molecule COc1ccc(C(=O)N(C)[C@@H](C)C/C(N)=N/O)cc1O less soluble in water? The output molecule should be similar to the input molecule.	COc1ccc(C(=O)c2cnc(C#N)c([C@@H](C)C/C(N)=N/O)c2)cc1O	COc1ccc(C(=O)N(C)[C@@H](C)C/C(N)=N/O)cc1O	COc1ccc(C(=O)c2cnc(C#N)c([C@@H](C)C/C(N)=N/O)c2)cc1O	102	{ "fragment_index": 0, "new_substring": "N#Cc1ncc&cc1&", "old_substring": "N24C" }
Can you make molecule O=C(Nc1nc[nH]n1)c1cccnc1Nc1cccc(F)c1 less soluble in water? The output molecule should be similar to the input molecule.	O=C1C2=CC=CC2=C(Nc2nc[nH]n2)CCN1c1cccnc1Nc1cccc(F)c1	O=C(Nc1nc[nH]n1)c1cccnc1Nc1cccc(F)c1	O=C1C2=CC=CC2=C(Nc2nc[nH]n2)CCN1c1cccnc1Nc1cccc(F)c1	102	{ "fragment_index": 0, "new_substring": "O=C1c2cccc&c2CCN1&", "old_substring": "O=C26" }
Can you make molecule O=C(Nc1nc[nH]n1)c1cccnc1Nc1cccc(F)c1 less soluble in water? The output molecule should be similar to the input molecule.	O=Cc1c(Nc2nc[nH]n2)cc(-c2cccnc2Nc2cccc(F)c2)ccc2oc1-2	O=C(Nc1nc[nH]n1)c1cccnc1Nc1cccc(F)c1	O=Cc1c(Nc2nc[nH]n2)cc(-c2cccnc2Nc2cccc(F)c2)ccc2oc1-2	102	{ "fragment_index": 0, "new_substring": "O=Cc1c&oc2ccc&cc12", "old_substring": "O=C26" }
Can you make molecule O=C(Nc1nc[nH]n1)c1cccnc1Nc1cccc(F)c1 less soluble in water? The output molecule should be similar to the input molecule.	O=C(/C=C/Sc1cccnc1Nc1cccc(F)c1)Nc1nc[nH]n1	O=C(Nc1nc[nH]n1)c1cccnc1Nc1cccc(F)c1	O=C(/C=C/Sc1cccnc1Nc1cccc(F)c1)Nc1nc[nH]n1	102	{ "fragment_index": 0, "new_substring": "O=C&/C=C/S&", "old_substring": "O=C26" }
Can you make molecule O=C(Nc1nc[nH]n1)c1cccnc1Nc1cccc(F)c1 less soluble in water? The output molecule should be similar to the input molecule.	O=Cc1sc(Nc2nc[nH]n2)nc1-c1cccnc1Nc1cccc(F)c1	O=C(Nc1nc[nH]n1)c1cccnc1Nc1cccc(F)c1	O=Cc1sc(Nc2nc[nH]n2)nc1-c1cccnc1Nc1cccc(F)c1	102	{ "fragment_index": 0, "new_substring": "O=Cc1sc&nc1&", "old_substring": "O=C26" }
Can you make molecule O=C(Nc1nc[nH]n1)c1cccnc1Nc1cccc(F)c1 less soluble in water? The output molecule should be similar to the input molecule.	O=Cc1nc(Nc2nc[nH]n2)sc1-c1cccnc1Nc1cccc(F)c1	O=C(Nc1nc[nH]n1)c1cccnc1Nc1cccc(F)c1	O=Cc1nc(Nc2nc[nH]n2)sc1-c1cccnc1Nc1cccc(F)c1	102	{ "fragment_index": 0, "new_substring": "O=Cc1nc&sc1&", "old_substring": "O=C26" }
Can you make molecule C[C@@H]1CN(C(=O)c2cc(Br)cn2C)CC[C@H]1[NH3+] less soluble in water? The output molecule should be similar to the input molecule.	C[C@@H]1CN(C(=O)c2cc(Br)cnc2Cl)CC[C@H]1[NH3+]	C[C@@H]1CN(C(=O)c2cc(Br)cn2C)CC[C@H]1[NH3+]	C[C@@H]1CN(C(=O)c2cc(Br)cnc2Cl)CC[C@H]1[NH3+]	102	{ "fragment_index": 0, "new_substring": "c1&cc(Br)cnc1Cl", "old_substring": "c14cc(Br)cn1C" }
Can you make molecule C[C@@H]1CN(C(=O)c2cc(Br)cn2C)CC[C@H]1[NH3+] less soluble in water? The output molecule should be similar to the input molecule.	C[C@@H]1CN(C(=O)c2cc(Br)ccc2Cl)CC[C@H]1[NH3+]	C[C@@H]1CN(C(=O)c2cc(Br)cn2C)CC[C@H]1[NH3+]	C[C@@H]1CN(C(=O)c2cc(Br)ccc2Cl)CC[C@H]1[NH3+]	102	{ "fragment_index": 0, "new_substring": "c1&cc(Br)ccc1Cl", "old_substring": "c14cc(Br)cn1C" }
Can you make molecule C[C@@H]1CN(C(=O)c2cc(Br)cn2C)CC[C@H]1[NH3+] less soluble in water? The output molecule should be similar to the input molecule.	C[C@@H]1CN(C(=O)c2cc(Br)ccc2I)CC[C@H]1[NH3+]	C[C@@H]1CN(C(=O)c2cc(Br)cn2C)CC[C@H]1[NH3+]	C[C@@H]1CN(C(=O)c2cc(Br)ccc2I)CC[C@H]1[NH3+]	102	{ "fragment_index": 0, "new_substring": "c1&cc(Br)ccc1I", "old_substring": "c14cc(Br)cn1C" }
Can you make molecule C[C@@H]1CN(C(=O)c2cc(Br)cn2C)CC[C@H]1[NH3+] less soluble in water? The output molecule should be similar to the input molecule.	C[C@@H]1CN(C(=O)c2cc(I)cnc2Cl)CC[C@H]1[NH3+]	C[C@@H]1CN(C(=O)c2cc(Br)cn2C)CC[C@H]1[NH3+]	C[C@@H]1CN(C(=O)c2cc(I)cnc2Cl)CC[C@H]1[NH3+]	102	{ "fragment_index": 0, "new_substring": "c1&cc(I)cnc1Cl", "old_substring": "c14cc(Br)cn1C" }
Can you make molecule C[C@@H]1CN(C(=O)c2cc(Br)cn2C)CC[C@H]1[NH3+] less soluble in water? The output molecule should be similar to the input molecule.	C[C@@H]1CN(C(=O)c2scc(Br)c2Br)CC[C@H]1[NH3+]	C[C@@H]1CN(C(=O)c2cc(Br)cn2C)CC[C@H]1[NH3+]	C[C@@H]1CN(C(=O)c2scc(Br)c2Br)CC[C@H]1[NH3+]	102	{ "fragment_index": 0, "new_substring": "c1&scc(Br)c1Br", "old_substring": "c14cc(Br)cn1C" }
Can you make molecule CCOc1ccc(OCC)c([C@H]2C(C#N)=C(N)N(c3ccccc3C(F)(F)F)C3=C2C(=O)CCC3)c1 less soluble in water? The output molecule should be similar to the input molecule.	CCOc1ccc(OCC)c([C@H]2C(C#N)=C(N)N(c3ccccc3SC(F)(F)F)C3=C2C(=O)CCC3)c1	CCOc1ccc(OCC)c([C@H]2C(C#N)=C(N)N(c3ccccc3C(F)(F)F)C3=C2C(=O)CCC3)c1	CCOc1ccc(OCC)c([C@H]2C(C#N)=C(N)N(c3ccccc3SC(F)(F)F)C3=C2C(=O)CCC3)c1	102	{ "fragment_index": 0, "new_substring": "S&C(F)(F)F", "old_substring": "C9(F)(F)F" }
Can you make molecule CCOc1ccc(OCC)c([C@H]2C(C#N)=C(N)N(c3ccccc3C(F)(F)F)C3=C2C(=O)CCC3)c1 less soluble in water? The output molecule should be similar to the input molecule.	CCOc1ccc(OCC)c([C@H]2C(C#N)=C(N)N(c3ccccc3CCCC(F)(F)F)C3=C2C(=O)CCC3)c1	CCOc1ccc(OCC)c([C@H]2C(C#N)=C(N)N(c3ccccc3C(F)(F)F)C3=C2C(=O)CCC3)c1	CCOc1ccc(OCC)c([C@H]2C(C#N)=C(N)N(c3ccccc3CCCC(F)(F)F)C3=C2C(=O)CCC3)c1	102	{ "fragment_index": 0, "new_substring": "C&CCC(F)(F)F", "old_substring": "C9(F)(F)F" }
Can you make molecule CCOc1ccc(OCC)c([C@H]2C(C#N)=C(N)N(c3ccccc3C(F)(F)F)C3=C2C(=O)CCC3)c1 less soluble in water? The output molecule should be similar to the input molecule.	CCOc1ccc(OCC)c([C@H]2C(C#N)=C(N)N(c3ccccc3CCCCC(F)(F)F)C3=C2C(=O)CCC3)c1	CCOc1ccc(OCC)c([C@H]2C(C#N)=C(N)N(c3ccccc3C(F)(F)F)C3=C2C(=O)CCC3)c1	CCOc1ccc(OCC)c([C@H]2C(C#N)=C(N)N(c3ccccc3CCCCC(F)(F)F)C3=C2C(=O)CCC3)c1	102	{ "fragment_index": 0, "new_substring": "C&CCCC(F)(F)F", "old_substring": "C9(F)(F)F" }
Can you make molecule CCOc1ccc(OCC)c([C@H]2C(C#N)=C(N)N(c3ccccc3C(F)(F)F)C3=C2C(=O)CCC3)c1 less soluble in water? The output molecule should be similar to the input molecule.	CCOc1ccc(OCC)c([C@H]2C(C#N)=C(N)N(c3ccccc3C(F)(F)C(F)(F)F)C3=C2C(=O)CCC3)c1	CCOc1ccc(OCC)c([C@H]2C(C#N)=C(N)N(c3ccccc3C(F)(F)F)C3=C2C(=O)CCC3)c1	CCOc1ccc(OCC)c([C@H]2C(C#N)=C(N)N(c3ccccc3C(F)(F)C(F)(F)F)C3=C2C(=O)CCC3)c1	102	{ "fragment_index": 0, "new_substring": "C&(F)(F)C(F)(F)F", "old_substring": "C9(F)(F)F" }
Can you make molecule CCOc1ccc(OCC)c([C@H]2C(C#N)=C(N)N(c3ccccc3C(F)(F)F)C3=C2C(=O)CCC3)c1 less soluble in water? The output molecule should be similar to the input molecule.	CCOc1ccc(OCC)c([C@H]2C(C#N)=C(N)N(c3ccccc3CC(F)(F)C(F)(F)F)C3=C2C(=O)CCC3)c1	CCOc1ccc(OCC)c([C@H]2C(C#N)=C(N)N(c3ccccc3C(F)(F)F)C3=C2C(=O)CCC3)c1	CCOc1ccc(OCC)c([C@H]2C(C#N)=C(N)N(c3ccccc3CC(F)(F)C(F)(F)F)C3=C2C(=O)CCC3)c1	102	{ "fragment_index": 0, "new_substring": "C&C(F)(F)C(F)(F)F", "old_substring": "C9(F)(F)F" }
Can you make molecule Cc1ccc2nc(S[C@H](C)C(=O)NC3CCC(C)CC3)n(C)c(=O)c2c1 less soluble in water? The output molecule should be similar to the input molecule.	Cc1ccc2nc(SCS[C@H](C)C(=O)NC3CCC(C)CC3)n(C)c(=O)c2c1	Cc1ccc2nc(S[C@H](C)C(=O)NC3CCC(C)CC3)n(C)c(=O)c2c1	Cc1ccc2nc(SCS[C@H](C)C(=O)NC3CCC(C)CC3)n(C)c(=O)c2c1	102	{ "fragment_index": 0, "new_substring": "S&CS&", "old_substring": "S57" }
Can you make molecule Cc1ccc2nc(S[C@H](C)C(=O)NC3CCC(C)CC3)n(C)c(=O)c2c1 less soluble in water? The output molecule should be similar to the input molecule.	Cc1ccc2nc(-c3ccc4c(c3)N([C@H](C)C(=O)NC3CCC(C)CC3)CCS4)n(C)c(=O)c2c1	Cc1ccc2nc(S[C@H](C)C(=O)NC3CCC(C)CC3)n(C)c(=O)c2c1	Cc1ccc2nc(-c3ccc4c(c3)N([C@H](C)C(=O)NC3CCC(C)CC3)CCS4)n(C)c(=O)c2c1	102	{ "fragment_index": 0, "new_substring": "N1&CCSc2ccc&cc21", "old_substring": "S57" }
Can you make molecule Cc1ccc2nc(S[C@H](C)C(=O)NC3CCC(C)CC3)n(C)c(=O)c2c1 less soluble in water? The output molecule should be similar to the input molecule.	Cc1ccc2nc(C(Cl)(Cl)[S@+]([O-])C[C@H](C)C(=O)NC3CCC(C)CC3)n(C)c(=O)c2c1	Cc1ccc2nc(S[C@H](C)C(=O)NC3CCC(C)CC3)n(C)c(=O)c2c1	Cc1ccc2nc(C(Cl)(Cl)[S@+]([O-])C[C@H](C)C(=O)NC3CCC(C)CC3)n(C)c(=O)c2c1	102	{ "fragment_index": 0, "new_substring": "O=[S@](C&)C&(Cl)Cl", "old_substring": "S57" }
Can you make molecule Cc1ccc2nc(S[C@H](C)C(=O)NC3CCC(C)CC3)n(C)c(=O)c2c1 less soluble in water? The output molecule should be similar to the input molecule.	Cc1ccc2nc(N/C(C#N)=C(\Cl)S[C@H](C)C(=O)NC3CCC(C)CC3)n(C)c(=O)c2c1	Cc1ccc2nc(S[C@H](C)C(=O)NC3CCC(C)CC3)n(C)c(=O)c2c1	Cc1ccc2nc(N/C(C#N)=C(\Cl)S[C@H](C)C(=O)NC3CCC(C)CC3)n(C)c(=O)c2c1	102	{ "fragment_index": 0, "new_substring": "S&/C(Cl)=C(\\C#N)N&", "old_substring": "S57" }
Can you make molecule Cc1ccc2nc(S[C@H](C)C(=O)NC3CCC(C)CC3)n(C)c(=O)c2c1 less soluble in water? The output molecule should be similar to the input molecule.	Cc1ccc2nc(-n3c(=S)n([C@H](C)C(=O)NC4CCC(C)CC4)c4ccccc43)n(C)c(=O)c2c1	Cc1ccc2nc(S[C@H](C)C(=O)NC3CCC(C)CC3)n(C)c(=O)c2c1	Cc1ccc2nc(-n3c(=S)n([C@H](C)C(=O)NC4CCC(C)CC4)c4ccccc43)n(C)c(=O)c2c1	102	{ "fragment_index": 0, "new_substring": "n1&c(=S)n&c2ccccc21", "old_substring": "S57" }
Can you make molecule O=C(N1CCc2c(F)ccc(F)c2C1)C1(O)Cc2ccccc2C1 less soluble in water? The output molecule should be similar to the input molecule.	O=C(C1OCc2ccccc2CO1)N1CCc2c(F)ccc(F)c2C1	O=C(N1CCc2c(F)ccc(F)c2C1)C1(O)Cc2ccccc2C1	O=C(C1OCc2ccccc2CO1)N1CCc2c(F)ccc(F)c2C1	102	{ "fragment_index": 0, "new_substring": "C1&OCc2ccccc2CO1", "old_substring": "C14(O)Cc2ccccc2C1" }
Can you make molecule O=C(N1CCc2c(F)ccc(F)c2C1)C1(O)Cc2ccccc2C1 less soluble in water? The output molecule should be similar to the input molecule.	CC1(C(=O)N2CCc3c(F)ccc(F)c3C2)Cc2ccccc2C1	O=C(N1CCc2c(F)ccc(F)c2C1)C1(O)Cc2ccccc2C1	CC1(C(=O)N2CCc3c(F)ccc(F)c3C2)Cc2ccccc2C1	102	{ "fragment_index": 0, "new_substring": "CC1&Cc2ccccc2C1", "old_substring": "C14(O)Cc2ccccc2C1" }
Can you make molecule O=C(N1CCc2c(F)ccc(F)c2C1)C1(O)Cc2ccccc2C1 less soluble in water? The output molecule should be similar to the input molecule.	O=C(CN1CCc2ccccc2CC1)N1CCc2c(F)ccc(F)c2C1	O=C(N1CCc2c(F)ccc(F)c2C1)C1(O)Cc2ccccc2C1	O=C(CN1CCc2ccccc2CC1)N1CCc2c(F)ccc(F)c2C1	102	{ "fragment_index": 0, "new_substring": "C&N1CCc2ccccc2CC1", "old_substring": "C14(O)Cc2ccccc2C1" }
Can you make molecule O=C(N1CCc2c(F)ccc(F)c2C1)C1(O)Cc2ccccc2C1 less soluble in water? The output molecule should be similar to the input molecule.	O=C(N1CCOc2ccccc2C1)N1CCc2c(F)ccc(F)c2C1	O=C(N1CCc2c(F)ccc(F)c2C1)C1(O)Cc2ccccc2C1	O=C(N1CCOc2ccccc2C1)N1CCc2c(F)ccc(F)c2C1	102	{ "fragment_index": 0, "new_substring": "N1&CCOc2ccccc2C1", "old_substring": "C14(O)Cc2ccccc2C1" }
Can you make molecule O=C(N1CCc2c(F)ccc(F)c2C1)C1(O)Cc2ccccc2C1 less soluble in water? The output molecule should be similar to the input molecule.	O=C(N1CCc2ccccc2C1)N1CCc2c(F)ccc(F)c2C1	O=C(N1CCc2c(F)ccc(F)c2C1)C1(O)Cc2ccccc2C1	O=C(N1CCc2ccccc2C1)N1CCc2c(F)ccc(F)c2C1	102	{ "fragment_index": 0, "new_substring": "N1&CCc2ccccc2C1", "old_substring": "C14(O)Cc2ccccc2C1" }
Can you make molecule Cc1ccccc1C(=O)N1CCC2(CC1)C[C@H](c1ccccc1)C(=O)N2C less soluble in water? The output molecule should be similar to the input molecule.	Cc1ccccc1C(=O)N1CCC2(CC1)C[C@H](c1ccccc1Cl)C(=O)N2C	Cc1ccccc1C(=O)N1CCC2(CC1)C[C@H](c1ccccc1)C(=O)N2C	Cc1ccccc1C(=O)N1CCC2(CC1)C[C@H](c1ccccc1Cl)C(=O)N2C	102	{ "fragment_index": 0, "new_substring": "c1&ccccc1Cl", "old_substring": "c15ccccc1" }
Can you make molecule Cc1ccccc1C(=O)N1CCC2(CC1)C[C@H](c1ccccc1)C(=O)N2C less soluble in water? The output molecule should be similar to the input molecule.	Cc1ccccc1C(=O)N1CCC2(CC1)C[C@H](c1ccc(I)cc1)C(=O)N2C	Cc1ccccc1C(=O)N1CCC2(CC1)C[C@H](c1ccccc1)C(=O)N2C	Cc1ccccc1C(=O)N1CCC2(CC1)C[C@H](c1ccc(I)cc1)C(=O)N2C	102	{ "fragment_index": 0, "new_substring": "c1&ccc(I)cc1", "old_substring": "c15ccccc1" }
Can you make molecule Cc1ccccc1C(=O)N1CCC2(CC1)C[C@H](c1ccccc1)C(=O)N2C less soluble in water? The output molecule should be similar to the input molecule.	Cc1ccc([C@H]2CC3(CCN(C(=O)c4ccccc4C)CC3)N(C)C2=O)cc1I	Cc1ccccc1C(=O)N1CCC2(CC1)C[C@H](c1ccccc1)C(=O)N2C	Cc1ccc([C@H]2CC3(CCN(C(=O)c4ccccc4C)CC3)N(C)C2=O)cc1I	102	{ "fragment_index": 0, "new_substring": "Cc1ccc&cc1I", "old_substring": "c15ccccc1" }
Can you make molecule Cc1ccccc1C(=O)N1CCC2(CC1)C[C@H](c1ccccc1)C(=O)N2C less soluble in water? The output molecule should be similar to the input molecule.	Cc1ccccc1C(=O)N1CCC2(CC1)C[C@H](c1cccc(Br)c1)C(=O)N2C	Cc1ccccc1C(=O)N1CCC2(CC1)C[C@H](c1ccccc1)C(=O)N2C	Cc1ccccc1C(=O)N1CCC2(CC1)C[C@H](c1cccc(Br)c1)C(=O)N2C	102	{ "fragment_index": 0, "new_substring": "Brc1cccc&c1", "old_substring": "c15ccccc1" }
Can you make molecule Cc1ccccc1C(=O)N1CCC2(CC1)C[C@H](c1ccccc1)C(=O)N2C less soluble in water? The output molecule should be similar to the input molecule.	Cc1ccccc1C(=O)N1CCC2(CC1)C[C@H](c1cccc(C)c1C)C(=O)N2C	Cc1ccccc1C(=O)N1CCC2(CC1)C[C@H](c1ccccc1)C(=O)N2C	Cc1ccccc1C(=O)N1CCC2(CC1)C[C@H](c1cccc(C)c1C)C(=O)N2C	102	{ "fragment_index": 0, "new_substring": "c1&cccc(C)c1C", "old_substring": "c15ccccc1" }
Can you make molecule CCCc1cc(NC(=O)CN2C(=O)NC3(CCC(C)CC3)C2=O)n(C)n1 less soluble in water? The output molecule should be similar to the input molecule.	CC1CCC2(CC1)NC(=O)N(CC(=O)Nc1cc(C3CC(C)C3)nn1C)C2=O	CCCc1cc(NC(=O)CN2C(=O)NC3(CCC(C)CC3)C2=O)n(C)n1	CC1CCC2(CC1)NC(=O)N(CC(=O)Nc1cc(C3CC(C)C3)nn1C)C2=O	102	{ "fragment_index": 0, "new_substring": "CC1CC&C1", "old_substring": "CCC7" }
Can you make molecule CCCc1cc(NC(=O)CN2C(=O)NC3(CCC(C)CC3)C2=O)n(C)n1 less soluble in water? The output molecule should be similar to the input molecule.	CC(C)CCc1cc(NC(=O)CN2C(=O)NC3(CCC(C)CC3)C2=O)n(C)n1	CCCc1cc(NC(=O)CN2C(=O)NC3(CCC(C)CC3)C2=O)n(C)n1	CC(C)CCc1cc(NC(=O)CN2C(=O)NC3(CCC(C)CC3)C2=O)n(C)n1	102	{ "fragment_index": 0, "new_substring": "CC(C)CC&", "old_substring": "CCC7" }
Can you make molecule CCCc1cc(NC(=O)CN2C(=O)NC3(CCC(C)CC3)C2=O)n(C)n1 less soluble in water? The output molecule should be similar to the input molecule.	CC1CCC2(CC1)NC(=O)N(CC(=O)Nc1cc(CCCCBr)nn1C)C2=O	CCCc1cc(NC(=O)CN2C(=O)NC3(CCC(C)CC3)C2=O)n(C)n1	CC1CCC2(CC1)NC(=O)N(CC(=O)Nc1cc(CCCCBr)nn1C)C2=O	102	{ "fragment_index": 0, "new_substring": "C&CCCBr", "old_substring": "CCC7" }
Can you make molecule CCCc1cc(NC(=O)CN2C(=O)NC3(CCC(C)CC3)C2=O)n(C)n1 less soluble in water? The output molecule should be similar to the input molecule.	C=CCCCc1cc(NC(=O)CN2C(=O)NC3(CCC(C)CC3)C2=O)n(C)n1	CCCc1cc(NC(=O)CN2C(=O)NC3(CCC(C)CC3)C2=O)n(C)n1	C=CCCCc1cc(NC(=O)CN2C(=O)NC3(CCC(C)CC3)C2=O)n(C)n1	102	{ "fragment_index": 0, "new_substring": "C=CCCC&", "old_substring": "CCC7" }
Can you make molecule CCCc1cc(NC(=O)CN2C(=O)NC3(CCC(C)CC3)C2=O)n(C)n1 less soluble in water? The output molecule should be similar to the input molecule.	CC1CCC2(CC1)NC(=O)N(CC(=O)Nc1cc(CCCCCl)nn1C)C2=O	CCCc1cc(NC(=O)CN2C(=O)NC3(CCC(C)CC3)C2=O)n(C)n1	CC1CCC2(CC1)NC(=O)N(CC(=O)Nc1cc(CCCCCl)nn1C)C2=O	102	{ "fragment_index": 0, "new_substring": "C&CCCCl", "old_substring": "CCC7" }
Can you make molecule CC(C)Cc1nc(SCC(=O)NC[C@@H]2CCCO2)c2c(=O)n(C)c(=O)n(C)c2n1 less soluble in water? The output molecule should be similar to the input molecule.	CC(C)Cc1nc(SCC(=O)NC[C@@H]2CCSC2)c2c(=O)n(C)c(=O)n(C)c2n1	CC(C)Cc1nc(SCC(=O)NC[C@@H]2CCCO2)c2c(=O)n(C)c(=O)n(C)c2n1	CC(C)Cc1nc(SCC(=O)NC[C@@H]2CCSC2)c2c(=O)n(C)c(=O)n(C)c2n1	102	{ "fragment_index": 0, "new_substring": "[C@@H]1&CCSC1", "old_substring": "[C@@H]16CCCO1" }
Can you make molecule CC(C)Cc1nc(SCC(=O)NC[C@@H]2CCCO2)c2c(=O)n(C)c(=O)n(C)c2n1 less soluble in water? The output molecule should be similar to the input molecule.	CC(C)Cc1nc(SCC(=O)NC[C@@H]2C=CCC2)c2c(=O)n(C)c(=O)n(C)c2n1	CC(C)Cc1nc(SCC(=O)NC[C@@H]2CCCO2)c2c(=O)n(C)c(=O)n(C)c2n1	CC(C)Cc1nc(SCC(=O)NC[C@@H]2C=CCC2)c2c(=O)n(C)c(=O)n(C)c2n1	102	{ "fragment_index": 0, "new_substring": "[C@@H]1&C=CCC1", "old_substring": "[C@@H]16CCCO1" }
Can you make molecule CC(C)Cc1nc(SCC(=O)NC[C@@H]2CCCO2)c2c(=O)n(C)c(=O)n(C)c2n1 less soluble in water? The output molecule should be similar to the input molecule.	CC(C)Cc1nc(SCC(=O)NC[C@@H]2CCCSC2)c2c(=O)n(C)c(=O)n(C)c2n1	CC(C)Cc1nc(SCC(=O)NC[C@@H]2CCCO2)c2c(=O)n(C)c(=O)n(C)c2n1	CC(C)Cc1nc(SCC(=O)NC[C@@H]2CCCSC2)c2c(=O)n(C)c(=O)n(C)c2n1	102	{ "fragment_index": 0, "new_substring": "[C@@H]1&CCCSC1", "old_substring": "[C@@H]16CCCO1" }
Can you make molecule CC(C)Cc1nc(SCC(=O)NC[C@@H]2CCCO2)c2c(=O)n(C)c(=O)n(C)c2n1 less soluble in water? The output molecule should be similar to the input molecule.	CC(C)Cc1nc(SCC(=O)NC[C@H]2CCCOCC2)c2c(=O)n(C)c(=O)n(C)c2n1	CC(C)Cc1nc(SCC(=O)NC[C@@H]2CCCO2)c2c(=O)n(C)c(=O)n(C)c2n1	CC(C)Cc1nc(SCC(=O)NC[C@H]2CCCOCC2)c2c(=O)n(C)c(=O)n(C)c2n1	102	{ "fragment_index": 0, "new_substring": "[C@H]1&CCCOCC1", "old_substring": "[C@@H]16CCCO1" }
Can you make molecule CC(C)Cc1nc(SCC(=O)NC[C@@H]2CCCO2)c2c(=O)n(C)c(=O)n(C)c2n1 less soluble in water? The output molecule should be similar to the input molecule.	CC(C)Cc1nc(SCC(=O)NC[C@@H]2CCCO[C@H]2C)c2c(=O)n(C)c(=O)n(C)c2n1	CC(C)Cc1nc(SCC(=O)NC[C@@H]2CCCO2)c2c(=O)n(C)c(=O)n(C)c2n1	CC(C)Cc1nc(SCC(=O)NC[C@@H]2CCCO[C@H]2C)c2c(=O)n(C)c(=O)n(C)c2n1	102	{ "fragment_index": 0, "new_substring": "[C@@H]1&CCCO[C@H]1C", "old_substring": "[C@@H]16CCCO1" }
Can you make molecule Cc1ccc(CNC(=O)c2ccccc2NC(=O)[C@@H]2CC(=O)N(c3ccc(C)cc3)C2)cc1 less soluble in water? The output molecule should be similar to the input molecule.	Cc1ccc(CNC(=O)c2ccccc2NC(=O)[C@H]2CNC(=O)C2)cc1.Cc1cccc(Cl)c1	Cc1ccc(CNC(=O)c2ccccc2NC(=O)[C@@H]2CC(=O)N(c3ccc(C)cc3)C2)cc1	Cc1ccc(CNC(=O)c2ccccc2NC(=O)[C@H]2CNC(=O)C2)cc1.Cc1cccc(Cl)c1	102	{ "fragment_index": 0, "new_substring": "c1&ccc(C)cc1Cl", "old_substring": "c1%11ccc(C)cc1" }
Can you make molecule Cc1ccc(CNC(=O)c2ccccc2NC(=O)[C@@H]2CC(=O)N(c3ccc(C)cc3)C2)cc1 less soluble in water? The output molecule should be similar to the input molecule.	Cc1ccc(CNC(=O)c2ccccc2NC(=O)[C@H]2CNC(=O)C2)cc1.Clc1cccc(I)c1	Cc1ccc(CNC(=O)c2ccccc2NC(=O)[C@@H]2CC(=O)N(c3ccc(C)cc3)C2)cc1	Cc1ccc(CNC(=O)c2ccccc2NC(=O)[C@H]2CNC(=O)C2)cc1.Clc1cccc(I)c1	102	{ "fragment_index": 0, "new_substring": "c1&ccc(Cl)cc1I", "old_substring": "c1%11ccc(C)cc1" }
Can you make molecule Cc1ccc(CNC(=O)c2ccccc2NC(=O)[C@@H]2CC(=O)N(c3ccc(C)cc3)C2)cc1 less soluble in water? The output molecule should be similar to the input molecule.	Cc1ccc(CNC(=O)c2ccccc2NC(=O)[C@H]2CNC(=O)C2)cc1.Ic1ccccc1	Cc1ccc(CNC(=O)c2ccccc2NC(=O)[C@@H]2CC(=O)N(c3ccc(C)cc3)C2)cc1	Cc1ccc(CNC(=O)c2ccccc2NC(=O)[C@H]2CNC(=O)C2)cc1.Ic1ccccc1	102	{ "fragment_index": 0, "new_substring": "c1&ccc(I)cc1", "old_substring": "c1%11ccc(C)cc1" }
Can you make molecule Cc1ccc(CNC(=O)c2ccccc2NC(=O)[C@@H]2CC(=O)N(c3ccc(C)cc3)C2)cc1 less soluble in water? The output molecule should be similar to the input molecule.	Cc1ccc(CNC(=O)c2ccccc2NC(=O)[C@H]2CNC(=O)C2)cc1.Clc1cccc(Br)c1	Cc1ccc(CNC(=O)c2ccccc2NC(=O)[C@@H]2CC(=O)N(c3ccc(C)cc3)C2)cc1	Cc1ccc(CNC(=O)c2ccccc2NC(=O)[C@H]2CNC(=O)C2)cc1.Clc1cccc(Br)c1	102	{ "fragment_index": 0, "new_substring": "c1&ccc(Cl)cc1Br", "old_substring": "c1%11ccc(C)cc1" }
Can you make molecule Cc1ccc(CNC(=O)c2ccccc2NC(=O)[C@@H]2CC(=O)N(c3ccc(C)cc3)C2)cc1 less soluble in water? The output molecule should be similar to the input molecule.	Cc1ccc(CNC(=O)c2ccccc2NC(=O)[C@H]2CNC(=O)C2)cc1.Fc1cccc(I)c1	Cc1ccc(CNC(=O)c2ccccc2NC(=O)[C@@H]2CC(=O)N(c3ccc(C)cc3)C2)cc1	Cc1ccc(CNC(=O)c2ccccc2NC(=O)[C@H]2CNC(=O)C2)cc1.Fc1cccc(I)c1	102	{ "fragment_index": 0, "new_substring": "c1&ccc(I)cc1F", "old_substring": "c1%11ccc(C)cc1" }
Can you make molecule CCCCC(=O)NC(=S)Nc1ccccc1C(=O)N1CCOCC1 less soluble in water? The output molecule should be similar to the input molecule.	CCCCC(=O)NC(=N)Sc1ccccc1C(=O)N1CCOCC1	CCCCC(=O)NC(=S)Nc1ccccc1C(=O)N1CCOCC1	CCCCC(=O)NC(=N)Sc1ccccc1C(=O)N1CCOCC1	102	{ "fragment_index": 0, "new_substring": "N&C(=N)S&", "old_substring": "N2C(=S)N4" }
Can you make molecule CCCCC(=O)NC(=S)Nc1ccccc1C(=O)N1CCOCC1 less soluble in water? The output molecule should be similar to the input molecule.	CCCCC(=O)SC(=S)Nc1ccccc1C(=O)N1CCOCC1	CCCCC(=O)NC(=S)Nc1ccccc1C(=O)N1CCOCC1	CCCCC(=O)SC(=S)Nc1ccccc1C(=O)N1CCOCC1	102	{ "fragment_index": 0, "new_substring": "S&C(=S)N&", "old_substring": "N2C(=S)N4" }
Can you make molecule CCCCC(=O)NC(=S)Nc1ccccc1C(=O)N1CCOCC1 less soluble in water? The output molecule should be similar to the input molecule.	CCCCC(=O)NC(=S)N1CCC(c2ccccc2C(=O)N2CCOCC2)CC1	CCCCC(=O)NC(=S)Nc1ccccc1C(=O)N1CCOCC1	CCCCC(=O)NC(=S)N1CCC(c2ccccc2C(=O)N2CCOCC2)CC1	102	{ "fragment_index": 0, "new_substring": "N&C(=S)N1CCC&CC1", "old_substring": "N2C(=S)N4" }
Can you make molecule CCCCC(=O)NC(=S)Nc1ccccc1C(=O)N1CCOCC1 less soluble in water? The output molecule should be similar to the input molecule.	CCCCC(=O)NC(=S)N1CC[C@H](c2ccccc2C(=O)N2CCOCC2)C1	CCCCC(=O)NC(=S)Nc1ccccc1C(=O)N1CCOCC1	CCCCC(=O)NC(=S)N1CC[C@H](c2ccccc2C(=O)N2CCOCC2)C1	102	{ "fragment_index": 0, "new_substring": "N&C(=S)N1CC[C@H]&C1", "old_substring": "N2C(=S)N4" }
Can you make molecule CCCCC(=O)NC(=S)Nc1ccccc1C(=O)N1CCOCC1 less soluble in water? The output molecule should be similar to the input molecule.	CCCCC(=O)NC(=S)NN=C1CCC(c2ccccc2C(=O)N2CCOCC2)CC1	CCCCC(=O)NC(=S)Nc1ccccc1C(=O)N1CCOCC1	CCCCC(=O)NC(=S)NN=C1CCC(c2ccccc2C(=O)N2CCOCC2)CC1	102	{ "fragment_index": 0, "new_substring": "N&C(=S)NN=C1CCC&CC1", "old_substring": "N2C(=S)N4" }
Can you make molecule Cc1c(NC(=O)CSc2nc3sc4c(c3c(=O)[nH]2)CCCC4)c(=O)n(-c2ccccc2)n1C less soluble in water? The output molecule should be similar to the input molecule.	Cc1c(NSC(=O)CSc2nc3sc4c(c3c(=O)[nH]2)CCCC4)c(=O)n(-c2ccccc2)n1C	Cc1c(NC(=O)CSc2nc3sc4c(c3c(=O)[nH]2)CCCC4)c(=O)n(-c2ccccc2)n1C	Cc1c(NSC(=O)CSc2nc3sc4c(c3c(=O)[nH]2)CCCC4)c(=O)n(-c2ccccc2)n1C	102	{ "fragment_index": 0, "new_substring": "S&C(=O)C&", "old_substring": "C5(=O)C6" }
Can you make molecule Cc1c(NC(=O)CSc2nc3sc4c(c3c(=O)[nH]2)CCCC4)c(=O)n(-c2ccccc2)n1C less soluble in water? The output molecule should be similar to the input molecule.	Cc1c(NC(=O)CCCC(=O)Sc2nc3sc4c(c3c(=O)[nH]2)CCCC4)c(=O)n(-c2ccccc2)n1C	Cc1c(NC(=O)CSc2nc3sc4c(c3c(=O)[nH]2)CCCC4)c(=O)n(-c2ccccc2)n1C	Cc1c(NC(=O)CCCC(=O)Sc2nc3sc4c(c3c(=O)[nH]2)CCCC4)c(=O)n(-c2ccccc2)n1C	102	{ "fragment_index": 0, "new_substring": "C&(=O)CCCC&=O", "old_substring": "C5(=O)C6" }
Can you make molecule Cc1c(NC(=O)CSc2nc3sc4c(c3c(=O)[nH]2)CCCC4)c(=O)n(-c2ccccc2)n1C less soluble in water? The output molecule should be similar to the input molecule.	Cc1c(NC(=O)CC(C)(C)Sc2nc3sc4c(c3c(=O)[nH]2)CCCC4)c(=O)n(-c2ccccc2)n1C	Cc1c(NC(=O)CSc2nc3sc4c(c3c(=O)[nH]2)CCCC4)c(=O)n(-c2ccccc2)n1C	Cc1c(NC(=O)CC(C)(C)Sc2nc3sc4c(c3c(=O)[nH]2)CCCC4)c(=O)n(-c2ccccc2)n1C	102	{ "fragment_index": 0, "new_substring": "C&(=O)CC&(C)C", "old_substring": "C5(=O)C6" }
Can you make molecule Cc1c(NC(=O)CSc2nc3sc4c(c3c(=O)[nH]2)CCCC4)c(=O)n(-c2ccccc2)n1C less soluble in water? The output molecule should be similar to the input molecule.	Cc1c(NC[S@+]([O-])CCCSc2nc3sc4c(c3c(=O)[nH]2)CCCC4)c(=O)n(-c2ccccc2)n1C	Cc1c(NC(=O)CSc2nc3sc4c(c3c(=O)[nH]2)CCCC4)c(=O)n(-c2ccccc2)n1C	Cc1c(NC[S@+]([O-])CCCSc2nc3sc4c(c3c(=O)[nH]2)CCCC4)c(=O)n(-c2ccccc2)n1C	102	{ "fragment_index": 0, "new_substring": "C&[S@](=O)CCC&", "old_substring": "C5(=O)C6" }
Can you make molecule Cc1c(NC(=O)CSc2nc3sc4c(c3c(=O)[nH]2)CCCC4)c(=O)n(-c2ccccc2)n1C less soluble in water? The output molecule should be similar to the input molecule.	Cc1c(NC(=O)CCC(C)(C)Sc2nc3sc4c(c3c(=O)[nH]2)CCCC4)c(=O)n(-c2ccccc2)n1C	Cc1c(NC(=O)CSc2nc3sc4c(c3c(=O)[nH]2)CCCC4)c(=O)n(-c2ccccc2)n1C	Cc1c(NC(=O)CCC(C)(C)Sc2nc3sc4c(c3c(=O)[nH]2)CCCC4)c(=O)n(-c2ccccc2)n1C	102	{ "fragment_index": 0, "new_substring": "C&(=O)CCC&(C)C", "old_substring": "C5(=O)C6" }
Can you make molecule CC(C)[C@@H](Oc1cccc(Cl)c1)C(=O)N1CCC(n2cccn2)CC1 less soluble in water? The output molecule should be similar to the input molecule.	CC(C)[C@@H](Oc1cccc(Cl)c1)C(=O)N1CCC(n2cc(I)cn2)CC1	CC(C)[C@@H](Oc1cccc(Cl)c1)C(=O)N1CCC(n2cccn2)CC1	CC(C)[C@@H](Oc1cccc(Cl)c1)C(=O)N1CCC(n2cc(I)cn2)CC1	102	{ "fragment_index": 0, "new_substring": "n1&cc(I)cn1", "old_substring": "n16cccn1" }
Can you make molecule CC(C)[C@@H](Oc1cccc(Cl)c1)C(=O)N1CCC(n2cccn2)CC1 less soluble in water? The output molecule should be similar to the input molecule.	C=Cn1cc(C2CCN(C(=O)[C@H](Oc3cccc(Cl)c3)C(C)C)CC2)cn1	CC(C)[C@@H](Oc1cccc(Cl)c1)C(=O)N1CCC(n2cccn2)CC1	C=Cn1cc(C2CCN(C(=O)[C@H](Oc3cccc(Cl)c3)C(C)C)CC2)cn1	102	{ "fragment_index": 0, "new_substring": "C=Cn1cc&cn1", "old_substring": "n16cccn1" }
Can you make molecule CC(C)[C@@H](Oc1cccc(Cl)c1)C(=O)N1CCC(n2cccn2)CC1 less soluble in water? The output molecule should be similar to the input molecule.	Cc1cn(C2CCN(C(=O)[C@H](Oc3cccc(Cl)c3)C(C)C)CC2)nc1I	CC(C)[C@@H](Oc1cccc(Cl)c1)C(=O)N1CCC(n2cccn2)CC1	Cc1cn(C2CCN(C(=O)[C@H](Oc3cccc(Cl)c3)C(C)C)CC2)nc1I	102	{ "fragment_index": 0, "new_substring": "n1&cc(C)c(I)n1", "old_substring": "n16cccn1" }
Can you make molecule CC(C)[C@@H](Oc1cccc(Cl)c1)C(=O)N1CCC(n2cccn2)CC1 less soluble in water? The output molecule should be similar to the input molecule.	CC(C)[C@@H](Oc1cccc(Cl)c1)C(=O)N1CCC(n2ccsc2=O)CC1	CC(C)[C@@H](Oc1cccc(Cl)c1)C(=O)N1CCC(n2cccn2)CC1	CC(C)[C@@H](Oc1cccc(Cl)c1)C(=O)N1CCC(n2ccsc2=O)CC1	102	{ "fragment_index": 0, "new_substring": "n1&ccsc1=O", "old_substring": "n16cccn1" }
Can you make molecule CC(C)[C@@H](Oc1cccc(Cl)c1)C(=O)N1CCC(n2cccn2)CC1 less soluble in water? The output molecule should be similar to the input molecule.	Cc1cc(C)n(C2CCN(C(=O)[C@H](Oc3cccc(Cl)c3)C(C)C)CC2)n1	CC(C)[C@@H](Oc1cccc(Cl)c1)C(=O)N1CCC(n2cccn2)CC1	Cc1cc(C)n(C2CCN(C(=O)[C@H](Oc3cccc(Cl)c3)C(C)C)CC2)n1	102	{ "fragment_index": 0, "new_substring": "n1&nc(C)cc1C", "old_substring": "n16cccn1" }
Can you make molecule CCN(CC)C(=O)C[C@@H](C)[NH2+][C@H](C)c1cccc(F)c1F less soluble in water? The output molecule should be similar to the input molecule.	CCN(CC)C(=O)C[C@H]([NH2+][C@H](C)c1cccc(F)c1F)C(C)C	CCN(CC)C(=O)C[C@@H](C)[NH2+][C@H](C)c1cccc(F)c1F	CCN(CC)C(=O)C[C@H]([NH2+][C@H](C)c1cccc(F)c1F)C(C)C	102	{ "fragment_index": 0, "new_substring": "C&(=O)C[C@H]&C(C)C", "old_substring": "C2(=O)C[C@H]5C" }
Can you make molecule CCN(CC)C(=O)C[C@@H](C)[NH2+][C@H](C)c1cccc(F)c1F less soluble in water? The output molecule should be similar to the input molecule.	CCN(CC)CC[C@H](Cl)[NH2+][C@H](C)c1cccc(F)c1F	CCN(CC)C(=O)C[C@@H](C)[NH2+][C@H](C)c1cccc(F)c1F	CCN(CC)CC[C@H](Cl)[NH2+][C@H](C)c1cccc(F)c1F	102	{ "fragment_index": 0, "new_substring": "C&C[C@@H]&Cl", "old_substring": "C2(=O)C[C@H]5C" }
Can you make molecule CCN(CC)C(=O)C[C@@H](C)[NH2+][C@H](C)c1cccc(F)c1F less soluble in water? The output molecule should be similar to the input molecule.	CCN(CC)[C@@H](CC[NH2+][C@H](C)c1cccc(F)c1F)C(C)C	CCN(CC)C(=O)C[C@@H](C)[NH2+][C@H](C)c1cccc(F)c1F	CCN(CC)[C@@H](CC[NH2+][C@H](C)c1cccc(F)c1F)C(C)C	102	{ "fragment_index": 0, "new_substring": "CC(C)[C@@H]&CC&", "old_substring": "C2(=O)C[C@H]5C" }
Can you make molecule CCN(CC)C(=O)C[C@@H](C)[NH2+][C@H](C)c1cccc(F)c1F less soluble in water? The output molecule should be similar to the input molecule.	CCN(CC)C(=O)CCC(C)(C)[NH2+][C@H](C)c1cccc(F)c1F	CCN(CC)C(=O)C[C@@H](C)[NH2+][C@H](C)c1cccc(F)c1F	CCN(CC)C(=O)CCC(C)(C)[NH2+][C@H](C)c1cccc(F)c1F	102	{ "fragment_index": 0, "new_substring": "C&(=O)CCC&(C)C", "old_substring": "C2(=O)C[C@H]5C" }
Can you make molecule CCN(CC)C(=O)C[C@@H](C)[NH2+][C@H](C)c1cccc(F)c1F less soluble in water? The output molecule should be similar to the input molecule.	CCN(CC)CC[C@H](Br)C[NH2+][C@H](C)c1cccc(F)c1F	CCN(CC)C(=O)C[C@@H](C)[NH2+][C@H](C)c1cccc(F)c1F	CCN(CC)CC[C@H](Br)C[NH2+][C@H](C)c1cccc(F)c1F	102	{ "fragment_index": 0, "new_substring": "C&C[C@H](Br)C&", "old_substring": "C2(=O)C[C@H]5C" }

Can you make molecule CC(C)(C)c1ccc2occ(CC(=O)Nc3ccccc3F)c2c1 less soluble in water? The output molecule should be similar to the input molecule.

CC(C)(C)c1ccc2occ(CCC(CO)=Nc3ccccc3F)c2c1

CC(C)(C)c1ccc2occ(CC(=O)Nc3ccccc3F)c2c1

CC(C)(C)c1ccc2occ(CCC(CO)=Nc3ccccc3F)c2c1

102

{ "fragment_index": 0, "new_substring": "C&CC=&CO", "old_substring": "C7C4=O" }

Can you make molecule CC(C)(C)c1ccc2occ(CC(=O)Nc3ccccc3F)c2c1 less soluble in water? The output molecule should be similar to the input molecule.

C/C(Cc1coc2ccc(C(C)(C)C)cc12)=N/ONc1ccccc1F

CC(C)(C)c1ccc2occ(CC(=O)Nc3ccccc3F)c2c1

C/C(Cc1coc2ccc(C(C)(C)C)cc12)=N/ONc1ccccc1F

102

{ "fragment_index": 0, "new_substring": "C/C(C&)=N/O&", "old_substring": "C7C4=O" }

Can you make molecule CC(C)(C)c1ccc2occ(CC(=O)Nc3ccccc3F)c2c1 less soluble in water? The output molecule should be similar to the input molecule.

CCC(CC)(C(=O)CNc1ccccc1F)c1coc2ccc(C(C)(C)C)cc12

CC(C)(C)c1ccc2occ(CC(=O)Nc3ccccc3F)c2c1

CCC(CC)(C(=O)CNc1ccccc1F)c1coc2ccc(C(C)(C)C)cc12

102

{ "fragment_index": 0, "new_substring": "CCC&(CC)C(=O)C&", "old_substring": "C7C4=O" }

Can you make molecule CC(C)(C)c1ccc2occ(CC(=O)Nc3ccccc3F)c2c1 less soluble in water? The output molecule should be similar to the input molecule.

CC(C)(C)c1ccc2occ(SSC(=O)Nc3ccccc3F)c2c1

CC(C)(C)c1ccc2occ(CC(=O)Nc3ccccc3F)c2c1

CC(C)(C)c1ccc2occ(SSC(=O)Nc3ccccc3F)c2c1

102

{ "fragment_index": 0, "new_substring": "S&SC&=O", "old_substring": "C7C4=O" }

Can you make molecule CC(C)(C)c1ccc2occ(CC(=O)Nc3ccccc3F)c2c1 less soluble in water? The output molecule should be similar to the input molecule.

CCC(CC)(C(=O)CCNc1ccccc1F)c1coc2ccc(C(C)(C)C)cc12

CC(C)(C)c1ccc2occ(CC(=O)Nc3ccccc3F)c2c1

CCC(CC)(C(=O)CCNc1ccccc1F)c1coc2ccc(C(C)(C)C)cc12

102

{ "fragment_index": 0, "new_substring": "CCC&(CC)C(=O)CC&", "old_substring": "C7C4=O" }

Can you make molecule C[C@@H]1CC(Nc2cncc(-c3nncn3C)c2)C[C@@H](C)C1 less soluble in water? The output molecule should be similar to the input molecule.

Cc1nnsc1-c1cncc(NC2C[C@@H](C)C[C@H](C)C2)c1

C[C@@H]1CC(Nc2cncc(-c3nncn3C)c2)C[C@@H](C)C1

Cc1nnsc1-c1cncc(NC2C[C@@H](C)C[C@H](C)C2)c1

102

{ "fragment_index": 0, "new_substring": "c1&snnc1C", "old_substring": "c16nncn1C" }

Can you make molecule C[C@@H]1CC(Nc2cncc(-c3nncn3C)c2)C[C@@H](C)C1 less soluble in water? The output molecule should be similar to the input molecule.

Cc1nonc1-c1cncc(NC2C[C@@H](C)C[C@H](C)C2)c1

C[C@@H]1CC(Nc2cncc(-c3nncn3C)c2)C[C@@H](C)C1

Cc1nonc1-c1cncc(NC2C[C@@H](C)C[C@H](C)C2)c1

102

{ "fragment_index": 0, "new_substring": "c1&nonc1C", "old_substring": "c16nncn1C" }

Can you make molecule C[C@@H]1CC(Nc2cncc(-c3nncn3C)c2)C[C@@H](C)C1 less soluble in water? The output molecule should be similar to the input molecule.

C[C@@H]1CC(Nc2cncc(-c3nnsc3Cl)c2)C[C@@H](C)C1

C[C@@H]1CC(Nc2cncc(-c3nncn3C)c2)C[C@@H](C)C1

C[C@@H]1CC(Nc2cncc(-c3nnsc3Cl)c2)C[C@@H](C)C1

102

{ "fragment_index": 0, "new_substring": "c1&nnsc1Cl", "old_substring": "c16nncn1C" }

Can you make molecule C[C@@H]1CC(Nc2cncc(-c3nncn3C)c2)C[C@@H](C)C1 less soluble in water? The output molecule should be similar to the input molecule.

C[C@@H]1CC(Nc2cncc(-c3nsnc3Cl)c2)C[C@@H](C)C1

C[C@@H]1CC(Nc2cncc(-c3nncn3C)c2)C[C@@H](C)C1

C[C@@H]1CC(Nc2cncc(-c3nsnc3Cl)c2)C[C@@H](C)C1

102

{ "fragment_index": 0, "new_substring": "c1&nsnc1Cl", "old_substring": "c16nncn1C" }

Can you make molecule C[C@@H]1CC(Nc2cncc(-c3nncn3C)c2)C[C@@H](C)C1 less soluble in water? The output molecule should be similar to the input molecule.

C[C@@H]1CC(Nc2cncc(-c3nnc4n3CCCS4)c2)C[C@@H](C)C1

C[C@@H]1CC(Nc2cncc(-c3nncn3C)c2)C[C@@H](C)C1

C[C@@H]1CC(Nc2cncc(-c3nnc4n3CCCS4)c2)C[C@@H](C)C1

102

{ "fragment_index": 0, "new_substring": "c1&nnc2n1CCCS2", "old_substring": "c16nncn1C" }

Can you make molecule N#Cc1ccc(-c2ccc(O[C@@H](C(=O)N3CCCC3)c3ccccc3)cc2)cc1 less soluble in water? The output molecule should be similar to the input molecule.

N#Cc1ccc(-c2ccc(O[C@@H]3C[C@](c4ccccc4)(N4CCCC4)CCO3)cc2)cc1

N#Cc1ccc(-c2ccc(O[C@@H](C(=O)N3CCCC3)c3ccccc3)cc2)cc1

N#Cc1ccc(-c2ccc(O[C@@H]3C[C@](c4ccccc4)(N4CCCC4)CCO3)cc2)cc1

102

{ "fragment_index": 0, "new_substring": "[C@@H]1&C[C@]&&CCO1", "old_substring": "[C@@H]57C4=O" }

Can you make molecule N#Cc1ccc(-c2ccc(O[C@@H](C(=O)N3CCCC3)c3ccccc3)cc2)cc1 less soluble in water? The output molecule should be similar to the input molecule.

N#Cc1ccc(-c2ccc(O[C@@H]3CCC[C@](c4ccccc4)(N4CCCC4)C3)cc2)cc1

N#Cc1ccc(-c2ccc(O[C@@H](C(=O)N3CCCC3)c3ccccc3)cc2)cc1

N#Cc1ccc(-c2ccc(O[C@@H]3CCC[C@](c4ccccc4)(N4CCCC4)C3)cc2)cc1

102

{ "fragment_index": 0, "new_substring": "[C@@H]1&CCC[C@]&&C1", "old_substring": "[C@@H]57C4=O" }

Can you make molecule N#Cc1ccc(-c2ccc(O[C@@H](C(=O)N3CCCC3)c3ccccc3)cc2)cc1 less soluble in water? The output molecule should be similar to the input molecule.

N#Cc1ccc(-c2ccc(O[C@@H]3CC[C@H](c4ccccc4)N3N3CCCC3)cc2)cc1

N#Cc1ccc(-c2ccc(O[C@@H](C(=O)N3CCCC3)c3ccccc3)cc2)cc1

N#Cc1ccc(-c2ccc(O[C@@H]3CC[C@H](c4ccccc4)N3N3CCCC3)cc2)cc1

102

{ "fragment_index": 0, "new_substring": "[C@@H]1&CC[C@H]&N1&", "old_substring": "[C@@H]57C4=O" }

Can you make molecule N#Cc1ccc(-c2ccc(O[C@@H](C(=O)N3CCCC3)c3ccccc3)cc2)cc1 less soluble in water? The output molecule should be similar to the input molecule.

N#Cc1ccc(-c2ccc(OCC[C@H](Cc3ccccc3)C(=O)N3CCCC3)cc2)cc1

N#Cc1ccc(-c2ccc(O[C@@H](C(=O)N3CCCC3)c3ccccc3)cc2)cc1

N#Cc1ccc(-c2ccc(OCC[C@H](Cc3ccccc3)C(=O)N3CCCC3)cc2)cc1

102

{ "fragment_index": 0, "new_substring": "C&C[C@H](C&)C&=O", "old_substring": "[C@@H]57C4=O" }

Can you make molecule N#Cc1ccc(-c2ccc(O[C@@H](C(=O)N3CCCC3)c3ccccc3)cc2)cc1 less soluble in water? The output molecule should be similar to the input molecule.

N#Cc1ccc(-c2ccc(O[C@H]3CC[C@](c4ccccc4)(N4CCCC4)C3)cc2)cc1

N#Cc1ccc(-c2ccc(O[C@@H](C(=O)N3CCCC3)c3ccccc3)cc2)cc1

N#Cc1ccc(-c2ccc(O[C@H]3CC[C@](c4ccccc4)(N4CCCC4)C3)cc2)cc1

102

{ "fragment_index": 0, "new_substring": "[C@H]1&CC[C@]&&C1", "old_substring": "[C@@H]57C4=O" }

Can you make molecule CCOC(=O)[C@@H]1CCCN(C(=O)c2nc(-c3ccc(C)cc3)n3c2CCCCC3)C1 less soluble in water? The output molecule should be similar to the input molecule.

CCOC(=O)[C@@H]1N=NC=C1CCC(=O)c1nc(-c2ccc(C)cc2)n2c1CCCCC2

CCOC(=O)[C@@H]1CCCN(C(=O)c2nc(-c3ccc(C)cc3)n3c2CCCCC3)C1

CCOC(=O)[C@@H]1N=NC=C1CCC(=O)c1nc(-c2ccc(C)cc2)n2c1CCCCC2

102

{ "fragment_index": 0, "new_substring": "[C@@H]1&N=NC=C1CC&", "old_substring": "[C@@H]18CCCN5C1" }

Can you make molecule CCOC(=O)[C@@H]1CCCN(C(=O)c2nc(-c3ccc(C)cc3)n3c2CCCCC3)C1 less soluble in water? The output molecule should be similar to the input molecule.

CCOC(=O)[C@@H]1CC[C@@H](C(=O)c2nc(-c3ccc(C)cc3)n3c2CCCCC3)C1

CCOC(=O)[C@@H]1CCCN(C(=O)c2nc(-c3ccc(C)cc3)n3c2CCCCC3)C1

CCOC(=O)[C@@H]1CC[C@@H](C(=O)c2nc(-c3ccc(C)cc3)n3c2CCCCC3)C1

102

{ "fragment_index": 0, "new_substring": "[C@@H]1&CC[C@@H]&C1", "old_substring": "[C@@H]18CCCN5C1" }

Can you make molecule CCOC(=O)[C@@H]1CCCN(C(=O)c2nc(-c3ccc(C)cc3)n3c2CCCCC3)C1 less soluble in water? The output molecule should be similar to the input molecule.

CCOC(=O)[C@H]1C(CC(=O)c2nc(-c3ccc(C)cc3)n3c2CCCCC3)=CN=C1C

CCOC(=O)[C@@H]1CCCN(C(=O)c2nc(-c3ccc(C)cc3)n3c2CCCCC3)C1

CCOC(=O)[C@H]1C(CC(=O)c2nc(-c3ccc(C)cc3)n3c2CCCCC3)=CN=C1C

102

{ "fragment_index": 0, "new_substring": "[C@H]1&C(C&)=CN=C1C", "old_substring": "[C@@H]18CCCN5C1" }

Can you make molecule CCOC(=O)[C@@H]1CCCN(C(=O)c2nc(-c3ccc(C)cc3)n3c2CCCCC3)C1 less soluble in water? The output molecule should be similar to the input molecule.

CCOC(=O)[C@H](CCl)CCCC(=O)c1nc(-c2ccc(C)cc2)n2c1CCCCC2

CCOC(=O)[C@@H]1CCCN(C(=O)c2nc(-c3ccc(C)cc3)n3c2CCCCC3)C1

CCOC(=O)[C@H](CCl)CCCC(=O)c1nc(-c2ccc(C)cc2)n2c1CCCCC2

102

{ "fragment_index": 0, "new_substring": "[C@@H]&(CCl)CCC&", "old_substring": "[C@@H]18CCCN5C1" }

Can you make molecule CCOC(=O)[C@@H]1CCCN(C(=O)c2nc(-c3ccc(C)cc3)n3c2CCCCC3)C1 less soluble in water? The output molecule should be similar to the input molecule.

CCOC(=O)[C@H]1C=C[C@H](C(=O)c2nc(-c3ccc(C)cc3)n3c2CCCCC3)C1

CCOC(=O)[C@@H]1CCCN(C(=O)c2nc(-c3ccc(C)cc3)n3c2CCCCC3)C1

CCOC(=O)[C@H]1C=C[C@H](C(=O)c2nc(-c3ccc(C)cc3)n3c2CCCCC3)C1

102

{ "fragment_index": 0, "new_substring": "[C@H]1&C=C[C@H]&C1", "old_substring": "[C@@H]18CCCN5C1" }

Can you make molecule N#CC1=C(SCC(=O)Nc2cccc(Cl)c2)N=C([O-])[C@H](C#N)C12CCCCC2 less soluble in water? The output molecule should be similar to the input molecule.

N#CC1=C(SCCC(CO)=Nc2cccc(Cl)c2)N=C([O-])[C@H](C#N)C12CCCCC2

N#CC1=C(SCC(=O)Nc2cccc(Cl)c2)N=C([O-])[C@H](C#N)C12CCCCC2

N#CC1=C(SCCC(CO)=Nc2cccc(Cl)c2)N=C([O-])[C@H](C#N)C12CCCCC2

102

{ "fragment_index": 0, "new_substring": "C&CC=&CO", "old_substring": "C4C3=O" }

Can you make molecule N#CC1=C(SCC(=O)Nc2cccc(Cl)c2)N=C([O-])[C@H](C#N)C12CCCCC2 less soluble in water? The output molecule should be similar to the input molecule.

C/C(CSC1=C(C#N)C2(CCCCC2)[C@@H](C#N)C([O-])=N1)=N/ONc1cccc(Cl)c1

N#CC1=C(SCC(=O)Nc2cccc(Cl)c2)N=C([O-])[C@H](C#N)C12CCCCC2

C/C(CSC1=C(C#N)C2(CCCCC2)[C@@H](C#N)C([O-])=N1)=N/ONc1cccc(Cl)c1

102

{ "fragment_index": 0, "new_substring": "C/C(C&)=N/O&", "old_substring": "C4C3=O" }

Can you make molecule N#CC1=C(SCC(=O)Nc2cccc(Cl)c2)N=C([O-])[C@H](C#N)C12CCCCC2 less soluble in water? The output molecule should be similar to the input molecule.

CCC(CC)(SC1=C(C#N)C2(CCCCC2)[C@@H](C#N)C([O-])=N1)C(=O)CNc1cccc(Cl)c1

N#CC1=C(SCC(=O)Nc2cccc(Cl)c2)N=C([O-])[C@H](C#N)C12CCCCC2

CCC(CC)(SC1=C(C#N)C2(CCCCC2)[C@@H](C#N)C([O-])=N1)C(=O)CNc1cccc(Cl)c1

102

{ "fragment_index": 0, "new_substring": "CCC&(CC)C(=O)C&", "old_substring": "C4C3=O" }

Can you make molecule N#CC1=C(SCC(=O)Nc2cccc(Cl)c2)N=C([O-])[C@H](C#N)C12CCCCC2 less soluble in water? The output molecule should be similar to the input molecule.

N#CC1=C(SSSC(=O)Nc2cccc(Cl)c2)N=C([O-])[C@H](C#N)C12CCCCC2

N#CC1=C(SCC(=O)Nc2cccc(Cl)c2)N=C([O-])[C@H](C#N)C12CCCCC2

N#CC1=C(SSSC(=O)Nc2cccc(Cl)c2)N=C([O-])[C@H](C#N)C12CCCCC2

102

{ "fragment_index": 0, "new_substring": "S&SC&=O", "old_substring": "C4C3=O" }

Can you make molecule N#CC1=C(SCC(=O)Nc2cccc(Cl)c2)N=C([O-])[C@H](C#N)C12CCCCC2 less soluble in water? The output molecule should be similar to the input molecule.

CCC(CC)(SC1=C(C#N)C2(CCCCC2)[C@@H](C#N)C([O-])=N1)C(=O)CCNc1cccc(Cl)c1

N#CC1=C(SCC(=O)Nc2cccc(Cl)c2)N=C([O-])[C@H](C#N)C12CCCCC2

CCC(CC)(SC1=C(C#N)C2(CCCCC2)[C@@H](C#N)C([O-])=N1)C(=O)CCNc1cccc(Cl)c1

102

{ "fragment_index": 0, "new_substring": "CCC&(CC)C(=O)CC&", "old_substring": "C4C3=O" }

Can you make molecule CC[NH+](CC)[C@](C)(CC)[C@H](O)c1cscc1Br less soluble in water? The output molecule should be similar to the input molecule.

CC[NH+](C1(C)Cc2ccccc2C1)[C@](C)(CC)[C@H](O)c1cscc1Br

CC[NH+](CC)[C@](C)(CC)[C@H](O)c1cscc1Br

CC[NH+](C1(C)Cc2ccccc2C1)[C@](C)(CC)[C@H](O)c1cscc1Br

102

{ "fragment_index": 0, "new_substring": "CC1&Cc2ccccc2C1", "old_substring": "CC2" }

Can you make molecule CC[NH+](CC)[C@](C)(CC)[C@H](O)c1cscc1Br less soluble in water? The output molecule should be similar to the input molecule.

CC[NH+](C1=CC2=CC=C2OC(C)(C)C1)[C@](C)(CC)[C@H](O)c1cscc1Br

CC[NH+](CC)[C@](C)(CC)[C@H](O)c1cscc1Br

CC[NH+](C1=CC2=CC=C2OC(C)(C)C1)[C@](C)(CC)[C@H](O)c1cscc1Br

102

{ "fragment_index": 0, "new_substring": "CC1(C)Cc2cc&ccc2O1", "old_substring": "CC2" }

Can you make molecule CC[NH+](CC)[C@](C)(CC)[C@H](O)c1cscc1Br less soluble in water? The output molecule should be similar to the input molecule.

CC[NH+](N1CC(C)(C)Oc2ccccc21)[C@](C)(CC)[C@H](O)c1cscc1Br

CC[NH+](CC)[C@](C)(CC)[C@H](O)c1cscc1Br

CC[NH+](N1CC(C)(C)Oc2ccccc21)[C@](C)(CC)[C@H](O)c1cscc1Br

102

{ "fragment_index": 0, "new_substring": "CC1(C)CN&c2ccccc2O1", "old_substring": "CC2" }

Can you make molecule CC[NH+](CC)[C@](C)(CC)[C@H](O)c1cscc1Br less soluble in water? The output molecule should be similar to the input molecule.

CC[NH+](N1CC(C)(C)Sc2ccccc21)[C@](C)(CC)[C@H](O)c1cscc1Br

CC[NH+](CC)[C@](C)(CC)[C@H](O)c1cscc1Br

CC[NH+](N1CC(C)(C)Sc2ccccc21)[C@](C)(CC)[C@H](O)c1cscc1Br

102

{ "fragment_index": 0, "new_substring": "CC1(C)CN&c2ccccc2S1", "old_substring": "CC2" }

Can you make molecule CC[NH+](CC)[C@](C)(CC)[C@H](O)c1cscc1Br less soluble in water? The output molecule should be similar to the input molecule.

CC[NH+](C1C2CCC1CC2)[C@](C)(CC)[C@H](O)c1cscc1Br

CC[NH+](CC)[C@](C)(CC)[C@H](O)c1cscc1Br

CC[NH+](C1C2CCC1CC2)[C@](C)(CC)[C@H](O)c1cscc1Br

102

{ "fragment_index": 0, "new_substring": "C1&C2CCC1CC2", "old_substring": "CC2" }

Can you make molecule COc1ccc(C(=O)N(C)[C@@H](C)C/C(N)=N/O)cc1O less soluble in water? The output molecule should be similar to the input molecule.

COc1ccc(C(=O)c2nc(C#N)c([C@@H](C)C/C(N)=N/O)o2)cc1O

COc1ccc(C(=O)N(C)[C@@H](C)C/C(N)=N/O)cc1O

COc1ccc(C(=O)c2nc(C#N)c([C@@H](C)C/C(N)=N/O)o2)cc1O

102

{ "fragment_index": 0, "new_substring": "N#Cc1nc&oc1&", "old_substring": "N24C" }

Can you make molecule COc1ccc(C(=O)N(C)[C@@H](C)C/C(N)=N/O)cc1O less soluble in water? The output molecule should be similar to the input molecule.

COc1ccc(C(=O)c2cc(C#N)c([C@@H](C)C/C(N)=N/O)s2)cc1O

COc1ccc(C(=O)N(C)[C@@H](C)C/C(N)=N/O)cc1O

COc1ccc(C(=O)c2cc(C#N)c([C@@H](C)C/C(N)=N/O)s2)cc1O

102

{ "fragment_index": 0, "new_substring": "N#Cc1cc&sc1&", "old_substring": "N24C" }

Can you make molecule COc1ccc(C(=O)N(C)[C@@H](C)C/C(N)=N/O)cc1O less soluble in water? The output molecule should be similar to the input molecule.

COc1ccc(C(=O)c2ccc([C@@H](C)C/C(N)=N/O)c(C#N)c2)cc1O

COc1ccc(C(=O)N(C)[C@@H](C)C/C(N)=N/O)cc1O

COc1ccc(C(=O)c2ccc([C@@H](C)C/C(N)=N/O)c(C#N)c2)cc1O

102

{ "fragment_index": 0, "new_substring": "N#Cc1cc&ccc1&", "old_substring": "N24C" }

Can you make molecule COc1ccc(C(=O)N(C)[C@@H](C)C/C(N)=N/O)cc1O less soluble in water? The output molecule should be similar to the input molecule.

COc1ccc(C(=O)ON=C2CCN([C@@H](C)C/C(N)=N/O)CC2)cc1O

COc1ccc(C(=O)N(C)[C@@H](C)C/C(N)=N/O)cc1O

COc1ccc(C(=O)ON=C2CCN([C@@H](C)C/C(N)=N/O)CC2)cc1O

102

{ "fragment_index": 0, "new_substring": "O&N=C1CCN&CC1", "old_substring": "N24C" }

Can you make molecule COc1ccc(C(=O)N(C)[C@@H](C)C/C(N)=N/O)cc1O less soluble in water? The output molecule should be similar to the input molecule.

COc1ccc(C(=O)c2cnc(C#N)c([C@@H](C)C/C(N)=N/O)c2)cc1O

COc1ccc(C(=O)N(C)[C@@H](C)C/C(N)=N/O)cc1O

COc1ccc(C(=O)c2cnc(C#N)c([C@@H](C)C/C(N)=N/O)c2)cc1O

102

{ "fragment_index": 0, "new_substring": "N#Cc1ncc&cc1&", "old_substring": "N24C" }

Can you make molecule O=C(Nc1nc[nH]n1)c1cccnc1Nc1cccc(F)c1 less soluble in water? The output molecule should be similar to the input molecule.

O=C1C2=CC=CC2=C(Nc2nc[nH]n2)CCN1c1cccnc1Nc1cccc(F)c1

O=C(Nc1nc[nH]n1)c1cccnc1Nc1cccc(F)c1

O=C1C2=CC=CC2=C(Nc2nc[nH]n2)CCN1c1cccnc1Nc1cccc(F)c1

102

{ "fragment_index": 0, "new_substring": "O=C1c2cccc&c2CCN1&", "old_substring": "O=C26" }

Can you make molecule O=C(Nc1nc[nH]n1)c1cccnc1Nc1cccc(F)c1 less soluble in water? The output molecule should be similar to the input molecule.

O=Cc1c(Nc2nc[nH]n2)cc(-c2cccnc2Nc2cccc(F)c2)ccc2oc1-2

O=C(Nc1nc[nH]n1)c1cccnc1Nc1cccc(F)c1

O=Cc1c(Nc2nc[nH]n2)cc(-c2cccnc2Nc2cccc(F)c2)ccc2oc1-2

102

{ "fragment_index": 0, "new_substring": "O=Cc1c&oc2ccc&cc12", "old_substring": "O=C26" }

Can you make molecule O=C(Nc1nc[nH]n1)c1cccnc1Nc1cccc(F)c1 less soluble in water? The output molecule should be similar to the input molecule.

O=C(/C=C/Sc1cccnc1Nc1cccc(F)c1)Nc1nc[nH]n1

O=C(Nc1nc[nH]n1)c1cccnc1Nc1cccc(F)c1

O=C(/C=C/Sc1cccnc1Nc1cccc(F)c1)Nc1nc[nH]n1

102

{ "fragment_index": 0, "new_substring": "O=C&/C=C/S&", "old_substring": "O=C26" }

Can you make molecule O=C(Nc1nc[nH]n1)c1cccnc1Nc1cccc(F)c1 less soluble in water? The output molecule should be similar to the input molecule.

O=Cc1sc(Nc2nc[nH]n2)nc1-c1cccnc1Nc1cccc(F)c1

O=C(Nc1nc[nH]n1)c1cccnc1Nc1cccc(F)c1

O=Cc1sc(Nc2nc[nH]n2)nc1-c1cccnc1Nc1cccc(F)c1

102

{ "fragment_index": 0, "new_substring": "O=Cc1sc&nc1&", "old_substring": "O=C26" }

Can you make molecule O=C(Nc1nc[nH]n1)c1cccnc1Nc1cccc(F)c1 less soluble in water? The output molecule should be similar to the input molecule.

O=Cc1nc(Nc2nc[nH]n2)sc1-c1cccnc1Nc1cccc(F)c1

O=C(Nc1nc[nH]n1)c1cccnc1Nc1cccc(F)c1

O=Cc1nc(Nc2nc[nH]n2)sc1-c1cccnc1Nc1cccc(F)c1

102

{ "fragment_index": 0, "new_substring": "O=Cc1nc&sc1&", "old_substring": "O=C26" }

Can you make molecule C[C@@H]1CN(C(=O)c2cc(Br)cn2C)CC[C@H]1[NH3+] less soluble in water? The output molecule should be similar to the input molecule.

C[C@@H]1CN(C(=O)c2cc(Br)cnc2Cl)CC[C@H]1[NH3+]

C[C@@H]1CN(C(=O)c2cc(Br)cn2C)CC[C@H]1[NH3+]

C[C@@H]1CN(C(=O)c2cc(Br)cnc2Cl)CC[C@H]1[NH3+]

102

{ "fragment_index": 0, "new_substring": "c1&cc(Br)cnc1Cl", "old_substring": "c14cc(Br)cn1C" }

Can you make molecule C[C@@H]1CN(C(=O)c2cc(Br)cn2C)CC[C@H]1[NH3+] less soluble in water? The output molecule should be similar to the input molecule.

C[C@@H]1CN(C(=O)c2cc(Br)ccc2Cl)CC[C@H]1[NH3+]

C[C@@H]1CN(C(=O)c2cc(Br)cn2C)CC[C@H]1[NH3+]

C[C@@H]1CN(C(=O)c2cc(Br)ccc2Cl)CC[C@H]1[NH3+]

102

{ "fragment_index": 0, "new_substring": "c1&cc(Br)ccc1Cl", "old_substring": "c14cc(Br)cn1C" }

Can you make molecule C[C@@H]1CN(C(=O)c2cc(Br)cn2C)CC[C@H]1[NH3+] less soluble in water? The output molecule should be similar to the input molecule.

C[C@@H]1CN(C(=O)c2cc(Br)ccc2I)CC[C@H]1[NH3+]

C[C@@H]1CN(C(=O)c2cc(Br)cn2C)CC[C@H]1[NH3+]

C[C@@H]1CN(C(=O)c2cc(Br)ccc2I)CC[C@H]1[NH3+]

102

{ "fragment_index": 0, "new_substring": "c1&cc(Br)ccc1I", "old_substring": "c14cc(Br)cn1C" }

Can you make molecule C[C@@H]1CN(C(=O)c2cc(Br)cn2C)CC[C@H]1[NH3+] less soluble in water? The output molecule should be similar to the input molecule.

C[C@@H]1CN(C(=O)c2cc(I)cnc2Cl)CC[C@H]1[NH3+]

C[C@@H]1CN(C(=O)c2cc(Br)cn2C)CC[C@H]1[NH3+]

C[C@@H]1CN(C(=O)c2cc(I)cnc2Cl)CC[C@H]1[NH3+]

102

{ "fragment_index": 0, "new_substring": "c1&cc(I)cnc1Cl", "old_substring": "c14cc(Br)cn1C" }

Can you make molecule C[C@@H]1CN(C(=O)c2cc(Br)cn2C)CC[C@H]1[NH3+] less soluble in water? The output molecule should be similar to the input molecule.

C[C@@H]1CN(C(=O)c2scc(Br)c2Br)CC[C@H]1[NH3+]

C[C@@H]1CN(C(=O)c2cc(Br)cn2C)CC[C@H]1[NH3+]

C[C@@H]1CN(C(=O)c2scc(Br)c2Br)CC[C@H]1[NH3+]

102

{ "fragment_index": 0, "new_substring": "c1&scc(Br)c1Br", "old_substring": "c14cc(Br)cn1C" }

Can you make molecule CCOc1ccc(OCC)c([C@H]2C(C#N)=C(N)N(c3ccccc3C(F)(F)F)C3=C2C(=O)CCC3)c1 less soluble in water? The output molecule should be similar to the input molecule.

CCOc1ccc(OCC)c([C@H]2C(C#N)=C(N)N(c3ccccc3SC(F)(F)F)C3=C2C(=O)CCC3)c1

CCOc1ccc(OCC)c([C@H]2C(C#N)=C(N)N(c3ccccc3C(F)(F)F)C3=C2C(=O)CCC3)c1

CCOc1ccc(OCC)c([C@H]2C(C#N)=C(N)N(c3ccccc3SC(F)(F)F)C3=C2C(=O)CCC3)c1

102

{ "fragment_index": 0, "new_substring": "S&C(F)(F)F", "old_substring": "C9(F)(F)F" }

Can you make molecule CCOc1ccc(OCC)c([C@H]2C(C#N)=C(N)N(c3ccccc3C(F)(F)F)C3=C2C(=O)CCC3)c1 less soluble in water? The output molecule should be similar to the input molecule.

CCOc1ccc(OCC)c([C@H]2C(C#N)=C(N)N(c3ccccc3CCCC(F)(F)F)C3=C2C(=O)CCC3)c1

CCOc1ccc(OCC)c([C@H]2C(C#N)=C(N)N(c3ccccc3C(F)(F)F)C3=C2C(=O)CCC3)c1

CCOc1ccc(OCC)c([C@H]2C(C#N)=C(N)N(c3ccccc3CCCC(F)(F)F)C3=C2C(=O)CCC3)c1

102

{ "fragment_index": 0, "new_substring": "C&CCC(F)(F)F", "old_substring": "C9(F)(F)F" }

Can you make molecule CCOc1ccc(OCC)c([C@H]2C(C#N)=C(N)N(c3ccccc3C(F)(F)F)C3=C2C(=O)CCC3)c1 less soluble in water? The output molecule should be similar to the input molecule.

CCOc1ccc(OCC)c([C@H]2C(C#N)=C(N)N(c3ccccc3CCCCC(F)(F)F)C3=C2C(=O)CCC3)c1

CCOc1ccc(OCC)c([C@H]2C(C#N)=C(N)N(c3ccccc3C(F)(F)F)C3=C2C(=O)CCC3)c1

CCOc1ccc(OCC)c([C@H]2C(C#N)=C(N)N(c3ccccc3CCCCC(F)(F)F)C3=C2C(=O)CCC3)c1

102

{ "fragment_index": 0, "new_substring": "C&CCCC(F)(F)F", "old_substring": "C9(F)(F)F" }

Can you make molecule CCOc1ccc(OCC)c([C@H]2C(C#N)=C(N)N(c3ccccc3C(F)(F)F)C3=C2C(=O)CCC3)c1 less soluble in water? The output molecule should be similar to the input molecule.

CCOc1ccc(OCC)c([C@H]2C(C#N)=C(N)N(c3ccccc3C(F)(F)C(F)(F)F)C3=C2C(=O)CCC3)c1

CCOc1ccc(OCC)c([C@H]2C(C#N)=C(N)N(c3ccccc3C(F)(F)F)C3=C2C(=O)CCC3)c1

CCOc1ccc(OCC)c([C@H]2C(C#N)=C(N)N(c3ccccc3C(F)(F)C(F)(F)F)C3=C2C(=O)CCC3)c1

102

{ "fragment_index": 0, "new_substring": "C&(F)(F)C(F)(F)F", "old_substring": "C9(F)(F)F" }

Can you make molecule CCOc1ccc(OCC)c([C@H]2C(C#N)=C(N)N(c3ccccc3C(F)(F)F)C3=C2C(=O)CCC3)c1 less soluble in water? The output molecule should be similar to the input molecule.

CCOc1ccc(OCC)c([C@H]2C(C#N)=C(N)N(c3ccccc3CC(F)(F)C(F)(F)F)C3=C2C(=O)CCC3)c1

CCOc1ccc(OCC)c([C@H]2C(C#N)=C(N)N(c3ccccc3C(F)(F)F)C3=C2C(=O)CCC3)c1

CCOc1ccc(OCC)c([C@H]2C(C#N)=C(N)N(c3ccccc3CC(F)(F)C(F)(F)F)C3=C2C(=O)CCC3)c1

102

{ "fragment_index": 0, "new_substring": "C&C(F)(F)C(F)(F)F", "old_substring": "C9(F)(F)F" }

Can you make molecule Cc1ccc2nc(S[C@H](C)C(=O)NC3CCC(C)CC3)n(C)c(=O)c2c1 less soluble in water? The output molecule should be similar to the input molecule.

Cc1ccc2nc(SCS[C@H](C)C(=O)NC3CCC(C)CC3)n(C)c(=O)c2c1

Cc1ccc2nc(S[C@H](C)C(=O)NC3CCC(C)CC3)n(C)c(=O)c2c1

Cc1ccc2nc(SCS[C@H](C)C(=O)NC3CCC(C)CC3)n(C)c(=O)c2c1

102

{ "fragment_index": 0, "new_substring": "S&CS&", "old_substring": "S57" }

Can you make molecule Cc1ccc2nc(S[C@H](C)C(=O)NC3CCC(C)CC3)n(C)c(=O)c2c1 less soluble in water? The output molecule should be similar to the input molecule.

Cc1ccc2nc(-c3ccc4c(c3)N([C@H](C)C(=O)NC3CCC(C)CC3)CCS4)n(C)c(=O)c2c1

Cc1ccc2nc(S[C@H](C)C(=O)NC3CCC(C)CC3)n(C)c(=O)c2c1

Cc1ccc2nc(-c3ccc4c(c3)N([C@H](C)C(=O)NC3CCC(C)CC3)CCS4)n(C)c(=O)c2c1

102

{ "fragment_index": 0, "new_substring": "N1&CCSc2ccc&cc21", "old_substring": "S57" }

Can you make molecule Cc1ccc2nc(S[C@H](C)C(=O)NC3CCC(C)CC3)n(C)c(=O)c2c1 less soluble in water? The output molecule should be similar to the input molecule.

Cc1ccc2nc(C(Cl)(Cl)[S@+]([O-])C[C@H](C)C(=O)NC3CCC(C)CC3)n(C)c(=O)c2c1

Cc1ccc2nc(S[C@H](C)C(=O)NC3CCC(C)CC3)n(C)c(=O)c2c1

Cc1ccc2nc(C(Cl)(Cl)[S@+]([O-])C[C@H](C)C(=O)NC3CCC(C)CC3)n(C)c(=O)c2c1

102

{ "fragment_index": 0, "new_substring": "O=[S@](C&)C&(Cl)Cl", "old_substring": "S57" }

Can you make molecule Cc1ccc2nc(S[C@H](C)C(=O)NC3CCC(C)CC3)n(C)c(=O)c2c1 less soluble in water? The output molecule should be similar to the input molecule.

Cc1ccc2nc(N/C(C#N)=C(\Cl)S[C@H](C)C(=O)NC3CCC(C)CC3)n(C)c(=O)c2c1

Cc1ccc2nc(S[C@H](C)C(=O)NC3CCC(C)CC3)n(C)c(=O)c2c1

Cc1ccc2nc(N/C(C#N)=C(\Cl)S[C@H](C)C(=O)NC3CCC(C)CC3)n(C)c(=O)c2c1

102

{ "fragment_index": 0, "new_substring": "S&/C(Cl)=C(\\C#N)N&", "old_substring": "S57" }

Can you make molecule Cc1ccc2nc(S[C@H](C)C(=O)NC3CCC(C)CC3)n(C)c(=O)c2c1 less soluble in water? The output molecule should be similar to the input molecule.

Cc1ccc2nc(-n3c(=S)n([C@H](C)C(=O)NC4CCC(C)CC4)c4ccccc43)n(C)c(=O)c2c1

Cc1ccc2nc(S[C@H](C)C(=O)NC3CCC(C)CC3)n(C)c(=O)c2c1

Cc1ccc2nc(-n3c(=S)n([C@H](C)C(=O)NC4CCC(C)CC4)c4ccccc43)n(C)c(=O)c2c1

102

{ "fragment_index": 0, "new_substring": "n1&c(=S)n&c2ccccc21", "old_substring": "S57" }

Can you make molecule O=C(N1CCc2c(F)ccc(F)c2C1)C1(O)Cc2ccccc2C1 less soluble in water? The output molecule should be similar to the input molecule.

O=C(C1OCc2ccccc2CO1)N1CCc2c(F)ccc(F)c2C1

O=C(N1CCc2c(F)ccc(F)c2C1)C1(O)Cc2ccccc2C1

O=C(C1OCc2ccccc2CO1)N1CCc2c(F)ccc(F)c2C1

102

{ "fragment_index": 0, "new_substring": "C1&OCc2ccccc2CO1", "old_substring": "C14(O)Cc2ccccc2C1" }

Can you make molecule O=C(N1CCc2c(F)ccc(F)c2C1)C1(O)Cc2ccccc2C1 less soluble in water? The output molecule should be similar to the input molecule.

CC1(C(=O)N2CCc3c(F)ccc(F)c3C2)Cc2ccccc2C1

O=C(N1CCc2c(F)ccc(F)c2C1)C1(O)Cc2ccccc2C1

CC1(C(=O)N2CCc3c(F)ccc(F)c3C2)Cc2ccccc2C1

102

{ "fragment_index": 0, "new_substring": "CC1&Cc2ccccc2C1", "old_substring": "C14(O)Cc2ccccc2C1" }

Can you make molecule O=C(N1CCc2c(F)ccc(F)c2C1)C1(O)Cc2ccccc2C1 less soluble in water? The output molecule should be similar to the input molecule.

O=C(CN1CCc2ccccc2CC1)N1CCc2c(F)ccc(F)c2C1

O=C(N1CCc2c(F)ccc(F)c2C1)C1(O)Cc2ccccc2C1

O=C(CN1CCc2ccccc2CC1)N1CCc2c(F)ccc(F)c2C1

102

{ "fragment_index": 0, "new_substring": "C&N1CCc2ccccc2CC1", "old_substring": "C14(O)Cc2ccccc2C1" }

Can you make molecule O=C(N1CCc2c(F)ccc(F)c2C1)C1(O)Cc2ccccc2C1 less soluble in water? The output molecule should be similar to the input molecule.

O=C(N1CCOc2ccccc2C1)N1CCc2c(F)ccc(F)c2C1

O=C(N1CCc2c(F)ccc(F)c2C1)C1(O)Cc2ccccc2C1

O=C(N1CCOc2ccccc2C1)N1CCc2c(F)ccc(F)c2C1

102

{ "fragment_index": 0, "new_substring": "N1&CCOc2ccccc2C1", "old_substring": "C14(O)Cc2ccccc2C1" }

Can you make molecule O=C(N1CCc2c(F)ccc(F)c2C1)C1(O)Cc2ccccc2C1 less soluble in water? The output molecule should be similar to the input molecule.

O=C(N1CCc2ccccc2C1)N1CCc2c(F)ccc(F)c2C1

O=C(N1CCc2c(F)ccc(F)c2C1)C1(O)Cc2ccccc2C1

O=C(N1CCc2ccccc2C1)N1CCc2c(F)ccc(F)c2C1

102

{ "fragment_index": 0, "new_substring": "N1&CCc2ccccc2C1", "old_substring": "C14(O)Cc2ccccc2C1" }

Can you make molecule Cc1ccccc1C(=O)N1CCC2(CC1)C[C@H](c1ccccc1)C(=O)N2C less soluble in water? The output molecule should be similar to the input molecule.

Cc1ccccc1C(=O)N1CCC2(CC1)C[C@H](c1ccccc1Cl)C(=O)N2C

Cc1ccccc1C(=O)N1CCC2(CC1)C[C@H](c1ccccc1)C(=O)N2C

Cc1ccccc1C(=O)N1CCC2(CC1)C[C@H](c1ccccc1Cl)C(=O)N2C

102

{ "fragment_index": 0, "new_substring": "c1&ccccc1Cl", "old_substring": "c15ccccc1" }

Can you make molecule Cc1ccccc1C(=O)N1CCC2(CC1)C[C@H](c1ccccc1)C(=O)N2C less soluble in water? The output molecule should be similar to the input molecule.

Cc1ccccc1C(=O)N1CCC2(CC1)C[C@H](c1ccc(I)cc1)C(=O)N2C

Cc1ccccc1C(=O)N1CCC2(CC1)C[C@H](c1ccccc1)C(=O)N2C

Cc1ccccc1C(=O)N1CCC2(CC1)C[C@H](c1ccc(I)cc1)C(=O)N2C

102

{ "fragment_index": 0, "new_substring": "c1&ccc(I)cc1", "old_substring": "c15ccccc1" }

Can you make molecule Cc1ccccc1C(=O)N1CCC2(CC1)C[C@H](c1ccccc1)C(=O)N2C less soluble in water? The output molecule should be similar to the input molecule.

Cc1ccc([C@H]2CC3(CCN(C(=O)c4ccccc4C)CC3)N(C)C2=O)cc1I

Cc1ccccc1C(=O)N1CCC2(CC1)C[C@H](c1ccccc1)C(=O)N2C

Cc1ccc([C@H]2CC3(CCN(C(=O)c4ccccc4C)CC3)N(C)C2=O)cc1I

102

{ "fragment_index": 0, "new_substring": "Cc1ccc&cc1I", "old_substring": "c15ccccc1" }

Can you make molecule Cc1ccccc1C(=O)N1CCC2(CC1)C[C@H](c1ccccc1)C(=O)N2C less soluble in water? The output molecule should be similar to the input molecule.

Cc1ccccc1C(=O)N1CCC2(CC1)C[C@H](c1cccc(Br)c1)C(=O)N2C

Cc1ccccc1C(=O)N1CCC2(CC1)C[C@H](c1ccccc1)C(=O)N2C

Cc1ccccc1C(=O)N1CCC2(CC1)C[C@H](c1cccc(Br)c1)C(=O)N2C

102

{ "fragment_index": 0, "new_substring": "Brc1cccc&c1", "old_substring": "c15ccccc1" }

Can you make molecule Cc1ccccc1C(=O)N1CCC2(CC1)C[C@H](c1ccccc1)C(=O)N2C less soluble in water? The output molecule should be similar to the input molecule.

Cc1ccccc1C(=O)N1CCC2(CC1)C[C@H](c1cccc(C)c1C)C(=O)N2C

Cc1ccccc1C(=O)N1CCC2(CC1)C[C@H](c1ccccc1)C(=O)N2C

Cc1ccccc1C(=O)N1CCC2(CC1)C[C@H](c1cccc(C)c1C)C(=O)N2C

102

{ "fragment_index": 0, "new_substring": "c1&cccc(C)c1C", "old_substring": "c15ccccc1" }

Can you make molecule CCCc1cc(NC(=O)CN2C(=O)NC3(CCC(C)CC3)C2=O)n(C)n1 less soluble in water? The output molecule should be similar to the input molecule.

CC1CCC2(CC1)NC(=O)N(CC(=O)Nc1cc(C3CC(C)C3)nn1C)C2=O

CCCc1cc(NC(=O)CN2C(=O)NC3(CCC(C)CC3)C2=O)n(C)n1

CC1CCC2(CC1)NC(=O)N(CC(=O)Nc1cc(C3CC(C)C3)nn1C)C2=O

102

{ "fragment_index": 0, "new_substring": "CC1CC&C1", "old_substring": "CCC7" }

Can you make molecule CCCc1cc(NC(=O)CN2C(=O)NC3(CCC(C)CC3)C2=O)n(C)n1 less soluble in water? The output molecule should be similar to the input molecule.

CC(C)CCc1cc(NC(=O)CN2C(=O)NC3(CCC(C)CC3)C2=O)n(C)n1

CCCc1cc(NC(=O)CN2C(=O)NC3(CCC(C)CC3)C2=O)n(C)n1

CC(C)CCc1cc(NC(=O)CN2C(=O)NC3(CCC(C)CC3)C2=O)n(C)n1

102

{ "fragment_index": 0, "new_substring": "CC(C)CC&", "old_substring": "CCC7" }

Can you make molecule CCCc1cc(NC(=O)CN2C(=O)NC3(CCC(C)CC3)C2=O)n(C)n1 less soluble in water? The output molecule should be similar to the input molecule.

CC1CCC2(CC1)NC(=O)N(CC(=O)Nc1cc(CCCCBr)nn1C)C2=O

CCCc1cc(NC(=O)CN2C(=O)NC3(CCC(C)CC3)C2=O)n(C)n1

CC1CCC2(CC1)NC(=O)N(CC(=O)Nc1cc(CCCCBr)nn1C)C2=O

102

{ "fragment_index": 0, "new_substring": "C&CCCBr", "old_substring": "CCC7" }

Can you make molecule CCCc1cc(NC(=O)CN2C(=O)NC3(CCC(C)CC3)C2=O)n(C)n1 less soluble in water? The output molecule should be similar to the input molecule.

C=CCCCc1cc(NC(=O)CN2C(=O)NC3(CCC(C)CC3)C2=O)n(C)n1

CCCc1cc(NC(=O)CN2C(=O)NC3(CCC(C)CC3)C2=O)n(C)n1

C=CCCCc1cc(NC(=O)CN2C(=O)NC3(CCC(C)CC3)C2=O)n(C)n1

102

{ "fragment_index": 0, "new_substring": "C=CCCC&", "old_substring": "CCC7" }

Can you make molecule CCCc1cc(NC(=O)CN2C(=O)NC3(CCC(C)CC3)C2=O)n(C)n1 less soluble in water? The output molecule should be similar to the input molecule.

CC1CCC2(CC1)NC(=O)N(CC(=O)Nc1cc(CCCCCl)nn1C)C2=O

CCCc1cc(NC(=O)CN2C(=O)NC3(CCC(C)CC3)C2=O)n(C)n1

CC1CCC2(CC1)NC(=O)N(CC(=O)Nc1cc(CCCCCl)nn1C)C2=O

102

{ "fragment_index": 0, "new_substring": "C&CCCCl", "old_substring": "CCC7" }

Can you make molecule CC(C)Cc1nc(SCC(=O)NC[C@@H]2CCCO2)c2c(=O)n(C)c(=O)n(C)c2n1 less soluble in water? The output molecule should be similar to the input molecule.

CC(C)Cc1nc(SCC(=O)NC[C@@H]2CCSC2)c2c(=O)n(C)c(=O)n(C)c2n1

CC(C)Cc1nc(SCC(=O)NC[C@@H]2CCCO2)c2c(=O)n(C)c(=O)n(C)c2n1

CC(C)Cc1nc(SCC(=O)NC[C@@H]2CCSC2)c2c(=O)n(C)c(=O)n(C)c2n1

102

{ "fragment_index": 0, "new_substring": "[C@@H]1&CCSC1", "old_substring": "[C@@H]16CCCO1" }

Can you make molecule CC(C)Cc1nc(SCC(=O)NC[C@@H]2CCCO2)c2c(=O)n(C)c(=O)n(C)c2n1 less soluble in water? The output molecule should be similar to the input molecule.

CC(C)Cc1nc(SCC(=O)NC[C@@H]2C=CCC2)c2c(=O)n(C)c(=O)n(C)c2n1

CC(C)Cc1nc(SCC(=O)NC[C@@H]2CCCO2)c2c(=O)n(C)c(=O)n(C)c2n1

CC(C)Cc1nc(SCC(=O)NC[C@@H]2C=CCC2)c2c(=O)n(C)c(=O)n(C)c2n1

102

{ "fragment_index": 0, "new_substring": "[C@@H]1&C=CCC1", "old_substring": "[C@@H]16CCCO1" }

Can you make molecule CC(C)Cc1nc(SCC(=O)NC[C@@H]2CCCO2)c2c(=O)n(C)c(=O)n(C)c2n1 less soluble in water? The output molecule should be similar to the input molecule.

CC(C)Cc1nc(SCC(=O)NC[C@@H]2CCCSC2)c2c(=O)n(C)c(=O)n(C)c2n1

CC(C)Cc1nc(SCC(=O)NC[C@@H]2CCCO2)c2c(=O)n(C)c(=O)n(C)c2n1

CC(C)Cc1nc(SCC(=O)NC[C@@H]2CCCSC2)c2c(=O)n(C)c(=O)n(C)c2n1

102

{ "fragment_index": 0, "new_substring": "[C@@H]1&CCCSC1", "old_substring": "[C@@H]16CCCO1" }

Can you make molecule CC(C)Cc1nc(SCC(=O)NC[C@@H]2CCCO2)c2c(=O)n(C)c(=O)n(C)c2n1 less soluble in water? The output molecule should be similar to the input molecule.

CC(C)Cc1nc(SCC(=O)NC[C@H]2CCCOCC2)c2c(=O)n(C)c(=O)n(C)c2n1

CC(C)Cc1nc(SCC(=O)NC[C@@H]2CCCO2)c2c(=O)n(C)c(=O)n(C)c2n1

CC(C)Cc1nc(SCC(=O)NC[C@H]2CCCOCC2)c2c(=O)n(C)c(=O)n(C)c2n1

102

{ "fragment_index": 0, "new_substring": "[C@H]1&CCCOCC1", "old_substring": "[C@@H]16CCCO1" }

Can you make molecule CC(C)Cc1nc(SCC(=O)NC[C@@H]2CCCO2)c2c(=O)n(C)c(=O)n(C)c2n1 less soluble in water? The output molecule should be similar to the input molecule.

CC(C)Cc1nc(SCC(=O)NC[C@@H]2CCCO[C@H]2C)c2c(=O)n(C)c(=O)n(C)c2n1

CC(C)Cc1nc(SCC(=O)NC[C@@H]2CCCO2)c2c(=O)n(C)c(=O)n(C)c2n1

CC(C)Cc1nc(SCC(=O)NC[C@@H]2CCCO[C@H]2C)c2c(=O)n(C)c(=O)n(C)c2n1

102

{ "fragment_index": 0, "new_substring": "[C@@H]1&CCCO[C@H]1C", "old_substring": "[C@@H]16CCCO1" }

Can you make molecule Cc1ccc(CNC(=O)c2ccccc2NC(=O)[C@@H]2CC(=O)N(c3ccc(C)cc3)C2)cc1 less soluble in water? The output molecule should be similar to the input molecule.

Cc1ccc(CNC(=O)c2ccccc2NC(=O)[C@H]2CNC(=O)C2)cc1.Cc1cccc(Cl)c1

Cc1ccc(CNC(=O)c2ccccc2NC(=O)[C@@H]2CC(=O)N(c3ccc(C)cc3)C2)cc1

Cc1ccc(CNC(=O)c2ccccc2NC(=O)[C@H]2CNC(=O)C2)cc1.Cc1cccc(Cl)c1

102

{ "fragment_index": 0, "new_substring": "c1&ccc(C)cc1Cl", "old_substring": "c1%11ccc(C)cc1" }

Can you make molecule Cc1ccc(CNC(=O)c2ccccc2NC(=O)[C@@H]2CC(=O)N(c3ccc(C)cc3)C2)cc1 less soluble in water? The output molecule should be similar to the input molecule.

Cc1ccc(CNC(=O)c2ccccc2NC(=O)[C@H]2CNC(=O)C2)cc1.Clc1cccc(I)c1

Cc1ccc(CNC(=O)c2ccccc2NC(=O)[C@@H]2CC(=O)N(c3ccc(C)cc3)C2)cc1

Cc1ccc(CNC(=O)c2ccccc2NC(=O)[C@H]2CNC(=O)C2)cc1.Clc1cccc(I)c1

102

{ "fragment_index": 0, "new_substring": "c1&ccc(Cl)cc1I", "old_substring": "c1%11ccc(C)cc1" }

Can you make molecule Cc1ccc(CNC(=O)c2ccccc2NC(=O)[C@@H]2CC(=O)N(c3ccc(C)cc3)C2)cc1 less soluble in water? The output molecule should be similar to the input molecule.

Cc1ccc(CNC(=O)c2ccccc2NC(=O)[C@H]2CNC(=O)C2)cc1.Ic1ccccc1

Cc1ccc(CNC(=O)c2ccccc2NC(=O)[C@@H]2CC(=O)N(c3ccc(C)cc3)C2)cc1

Cc1ccc(CNC(=O)c2ccccc2NC(=O)[C@H]2CNC(=O)C2)cc1.Ic1ccccc1

102

{ "fragment_index": 0, "new_substring": "c1&ccc(I)cc1", "old_substring": "c1%11ccc(C)cc1" }

Can you make molecule Cc1ccc(CNC(=O)c2ccccc2NC(=O)[C@@H]2CC(=O)N(c3ccc(C)cc3)C2)cc1 less soluble in water? The output molecule should be similar to the input molecule.

Cc1ccc(CNC(=O)c2ccccc2NC(=O)[C@H]2CNC(=O)C2)cc1.Clc1cccc(Br)c1

Cc1ccc(CNC(=O)c2ccccc2NC(=O)[C@@H]2CC(=O)N(c3ccc(C)cc3)C2)cc1

Cc1ccc(CNC(=O)c2ccccc2NC(=O)[C@H]2CNC(=O)C2)cc1.Clc1cccc(Br)c1

102

{ "fragment_index": 0, "new_substring": "c1&ccc(Cl)cc1Br", "old_substring": "c1%11ccc(C)cc1" }

Can you make molecule Cc1ccc(CNC(=O)c2ccccc2NC(=O)[C@@H]2CC(=O)N(c3ccc(C)cc3)C2)cc1 less soluble in water? The output molecule should be similar to the input molecule.

Cc1ccc(CNC(=O)c2ccccc2NC(=O)[C@H]2CNC(=O)C2)cc1.Fc1cccc(I)c1

Cc1ccc(CNC(=O)c2ccccc2NC(=O)[C@@H]2CC(=O)N(c3ccc(C)cc3)C2)cc1

Cc1ccc(CNC(=O)c2ccccc2NC(=O)[C@H]2CNC(=O)C2)cc1.Fc1cccc(I)c1

102

{ "fragment_index": 0, "new_substring": "c1&ccc(I)cc1F", "old_substring": "c1%11ccc(C)cc1" }

Can you make molecule CCCCC(=O)NC(=S)Nc1ccccc1C(=O)N1CCOCC1 less soluble in water? The output molecule should be similar to the input molecule.

CCCCC(=O)NC(=N)Sc1ccccc1C(=O)N1CCOCC1

CCCCC(=O)NC(=S)Nc1ccccc1C(=O)N1CCOCC1

CCCCC(=O)NC(=N)Sc1ccccc1C(=O)N1CCOCC1

102

{ "fragment_index": 0, "new_substring": "N&C(=N)S&", "old_substring": "N2C(=S)N4" }

Can you make molecule CCCCC(=O)NC(=S)Nc1ccccc1C(=O)N1CCOCC1 less soluble in water? The output molecule should be similar to the input molecule.

CCCCC(=O)SC(=S)Nc1ccccc1C(=O)N1CCOCC1

CCCCC(=O)NC(=S)Nc1ccccc1C(=O)N1CCOCC1

CCCCC(=O)SC(=S)Nc1ccccc1C(=O)N1CCOCC1

102

{ "fragment_index": 0, "new_substring": "S&C(=S)N&", "old_substring": "N2C(=S)N4" }

Can you make molecule CCCCC(=O)NC(=S)Nc1ccccc1C(=O)N1CCOCC1 less soluble in water? The output molecule should be similar to the input molecule.

CCCCC(=O)NC(=S)N1CCC(c2ccccc2C(=O)N2CCOCC2)CC1

CCCCC(=O)NC(=S)Nc1ccccc1C(=O)N1CCOCC1

CCCCC(=O)NC(=S)N1CCC(c2ccccc2C(=O)N2CCOCC2)CC1

102

{ "fragment_index": 0, "new_substring": "N&C(=S)N1CCC&CC1", "old_substring": "N2C(=S)N4" }

Can you make molecule CCCCC(=O)NC(=S)Nc1ccccc1C(=O)N1CCOCC1 less soluble in water? The output molecule should be similar to the input molecule.

CCCCC(=O)NC(=S)N1CC[C@H](c2ccccc2C(=O)N2CCOCC2)C1

CCCCC(=O)NC(=S)Nc1ccccc1C(=O)N1CCOCC1

CCCCC(=O)NC(=S)N1CC[C@H](c2ccccc2C(=O)N2CCOCC2)C1

102

{ "fragment_index": 0, "new_substring": "N&C(=S)N1CC[C@H]&C1", "old_substring": "N2C(=S)N4" }

Can you make molecule CCCCC(=O)NC(=S)Nc1ccccc1C(=O)N1CCOCC1 less soluble in water? The output molecule should be similar to the input molecule.

CCCCC(=O)NC(=S)NN=C1CCC(c2ccccc2C(=O)N2CCOCC2)CC1

CCCCC(=O)NC(=S)Nc1ccccc1C(=O)N1CCOCC1

CCCCC(=O)NC(=S)NN=C1CCC(c2ccccc2C(=O)N2CCOCC2)CC1

102

{ "fragment_index": 0, "new_substring": "N&C(=S)NN=C1CCC&CC1", "old_substring": "N2C(=S)N4" }

Can you make molecule Cc1c(NC(=O)CSc2nc3sc4c(c3c(=O)[nH]2)CCCC4)c(=O)n(-c2ccccc2)n1C less soluble in water? The output molecule should be similar to the input molecule.

Cc1c(NSC(=O)CSc2nc3sc4c(c3c(=O)[nH]2)CCCC4)c(=O)n(-c2ccccc2)n1C

Cc1c(NC(=O)CSc2nc3sc4c(c3c(=O)[nH]2)CCCC4)c(=O)n(-c2ccccc2)n1C

Cc1c(NSC(=O)CSc2nc3sc4c(c3c(=O)[nH]2)CCCC4)c(=O)n(-c2ccccc2)n1C

102

{ "fragment_index": 0, "new_substring": "S&C(=O)C&", "old_substring": "C5(=O)C6" }

Can you make molecule Cc1c(NC(=O)CSc2nc3sc4c(c3c(=O)[nH]2)CCCC4)c(=O)n(-c2ccccc2)n1C less soluble in water? The output molecule should be similar to the input molecule.

Cc1c(NC(=O)CCCC(=O)Sc2nc3sc4c(c3c(=O)[nH]2)CCCC4)c(=O)n(-c2ccccc2)n1C

Cc1c(NC(=O)CSc2nc3sc4c(c3c(=O)[nH]2)CCCC4)c(=O)n(-c2ccccc2)n1C

Cc1c(NC(=O)CCCC(=O)Sc2nc3sc4c(c3c(=O)[nH]2)CCCC4)c(=O)n(-c2ccccc2)n1C

102

{ "fragment_index": 0, "new_substring": "C&(=O)CCCC&=O", "old_substring": "C5(=O)C6" }

Can you make molecule Cc1c(NC(=O)CSc2nc3sc4c(c3c(=O)[nH]2)CCCC4)c(=O)n(-c2ccccc2)n1C less soluble in water? The output molecule should be similar to the input molecule.

Cc1c(NC(=O)CC(C)(C)Sc2nc3sc4c(c3c(=O)[nH]2)CCCC4)c(=O)n(-c2ccccc2)n1C

Cc1c(NC(=O)CSc2nc3sc4c(c3c(=O)[nH]2)CCCC4)c(=O)n(-c2ccccc2)n1C

Cc1c(NC(=O)CC(C)(C)Sc2nc3sc4c(c3c(=O)[nH]2)CCCC4)c(=O)n(-c2ccccc2)n1C

102

{ "fragment_index": 0, "new_substring": "C&(=O)CC&(C)C", "old_substring": "C5(=O)C6" }

Can you make molecule Cc1c(NC(=O)CSc2nc3sc4c(c3c(=O)[nH]2)CCCC4)c(=O)n(-c2ccccc2)n1C less soluble in water? The output molecule should be similar to the input molecule.

Cc1c(NC[S@+]([O-])CCCSc2nc3sc4c(c3c(=O)[nH]2)CCCC4)c(=O)n(-c2ccccc2)n1C

Cc1c(NC(=O)CSc2nc3sc4c(c3c(=O)[nH]2)CCCC4)c(=O)n(-c2ccccc2)n1C

Cc1c(NC[S@+]([O-])CCCSc2nc3sc4c(c3c(=O)[nH]2)CCCC4)c(=O)n(-c2ccccc2)n1C

102

{ "fragment_index": 0, "new_substring": "C&[S@](=O)CCC&", "old_substring": "C5(=O)C6" }

Can you make molecule Cc1c(NC(=O)CSc2nc3sc4c(c3c(=O)[nH]2)CCCC4)c(=O)n(-c2ccccc2)n1C less soluble in water? The output molecule should be similar to the input molecule.

Cc1c(NC(=O)CCC(C)(C)Sc2nc3sc4c(c3c(=O)[nH]2)CCCC4)c(=O)n(-c2ccccc2)n1C

Cc1c(NC(=O)CSc2nc3sc4c(c3c(=O)[nH]2)CCCC4)c(=O)n(-c2ccccc2)n1C

Cc1c(NC(=O)CCC(C)(C)Sc2nc3sc4c(c3c(=O)[nH]2)CCCC4)c(=O)n(-c2ccccc2)n1C

102

{ "fragment_index": 0, "new_substring": "C&(=O)CCC&(C)C", "old_substring": "C5(=O)C6" }

Can you make molecule CC(C)[C@@H](Oc1cccc(Cl)c1)C(=O)N1CCC(n2cccn2)CC1 less soluble in water? The output molecule should be similar to the input molecule.

CC(C)[C@@H](Oc1cccc(Cl)c1)C(=O)N1CCC(n2cc(I)cn2)CC1

CC(C)[C@@H](Oc1cccc(Cl)c1)C(=O)N1CCC(n2cccn2)CC1

CC(C)[C@@H](Oc1cccc(Cl)c1)C(=O)N1CCC(n2cc(I)cn2)CC1

102

{ "fragment_index": 0, "new_substring": "n1&cc(I)cn1", "old_substring": "n16cccn1" }

Can you make molecule CC(C)[C@@H](Oc1cccc(Cl)c1)C(=O)N1CCC(n2cccn2)CC1 less soluble in water? The output molecule should be similar to the input molecule.

C=Cn1cc(C2CCN(C(=O)[C@H](Oc3cccc(Cl)c3)C(C)C)CC2)cn1

CC(C)[C@@H](Oc1cccc(Cl)c1)C(=O)N1CCC(n2cccn2)CC1

C=Cn1cc(C2CCN(C(=O)[C@H](Oc3cccc(Cl)c3)C(C)C)CC2)cn1

102

{ "fragment_index": 0, "new_substring": "C=Cn1cc&cn1", "old_substring": "n16cccn1" }

Can you make molecule CC(C)[C@@H](Oc1cccc(Cl)c1)C(=O)N1CCC(n2cccn2)CC1 less soluble in water? The output molecule should be similar to the input molecule.

Cc1cn(C2CCN(C(=O)[C@H](Oc3cccc(Cl)c3)C(C)C)CC2)nc1I

CC(C)[C@@H](Oc1cccc(Cl)c1)C(=O)N1CCC(n2cccn2)CC1

Cc1cn(C2CCN(C(=O)[C@H](Oc3cccc(Cl)c3)C(C)C)CC2)nc1I

102

{ "fragment_index": 0, "new_substring": "n1&cc(C)c(I)n1", "old_substring": "n16cccn1" }

Can you make molecule CC(C)[C@@H](Oc1cccc(Cl)c1)C(=O)N1CCC(n2cccn2)CC1 less soluble in water? The output molecule should be similar to the input molecule.

CC(C)[C@@H](Oc1cccc(Cl)c1)C(=O)N1CCC(n2ccsc2=O)CC1

CC(C)[C@@H](Oc1cccc(Cl)c1)C(=O)N1CCC(n2cccn2)CC1

CC(C)[C@@H](Oc1cccc(Cl)c1)C(=O)N1CCC(n2ccsc2=O)CC1

102

{ "fragment_index": 0, "new_substring": "n1&ccsc1=O", "old_substring": "n16cccn1" }

Can you make molecule CC(C)[C@@H](Oc1cccc(Cl)c1)C(=O)N1CCC(n2cccn2)CC1 less soluble in water? The output molecule should be similar to the input molecule.

Cc1cc(C)n(C2CCN(C(=O)[C@H](Oc3cccc(Cl)c3)C(C)C)CC2)n1

CC(C)[C@@H](Oc1cccc(Cl)c1)C(=O)N1CCC(n2cccn2)CC1

Cc1cc(C)n(C2CCN(C(=O)[C@H](Oc3cccc(Cl)c3)C(C)C)CC2)n1

102

{ "fragment_index": 0, "new_substring": "n1&nc(C)cc1C", "old_substring": "n16cccn1" }

Can you make molecule CCN(CC)C(=O)C[C@@H](C)[NH2+][C@H](C)c1cccc(F)c1F less soluble in water? The output molecule should be similar to the input molecule.

CCN(CC)C(=O)C[C@H]([NH2+][C@H](C)c1cccc(F)c1F)C(C)C

CCN(CC)C(=O)C[C@@H](C)[NH2+][C@H](C)c1cccc(F)c1F

CCN(CC)C(=O)C[C@H]([NH2+][C@H](C)c1cccc(F)c1F)C(C)C

102

{ "fragment_index": 0, "new_substring": "C&(=O)C[C@H]&C(C)C", "old_substring": "C2(=O)C[C@H]5C" }

Can you make molecule CCN(CC)C(=O)C[C@@H](C)[NH2+][C@H](C)c1cccc(F)c1F less soluble in water? The output molecule should be similar to the input molecule.

CCN(CC)CC[C@H](Cl)[NH2+][C@H](C)c1cccc(F)c1F

CCN(CC)C(=O)C[C@@H](C)[NH2+][C@H](C)c1cccc(F)c1F

CCN(CC)CC[C@H](Cl)[NH2+][C@H](C)c1cccc(F)c1F

102

{ "fragment_index": 0, "new_substring": "C&C[C@@H]&Cl", "old_substring": "C2(=O)C[C@H]5C" }

Can you make molecule CCN(CC)C(=O)C[C@@H](C)[NH2+][C@H](C)c1cccc(F)c1F less soluble in water? The output molecule should be similar to the input molecule.

CCN(CC)[C@@H](CC[NH2+][C@H](C)c1cccc(F)c1F)C(C)C

CCN(CC)C(=O)C[C@@H](C)[NH2+][C@H](C)c1cccc(F)c1F

CCN(CC)[C@@H](CC[NH2+][C@H](C)c1cccc(F)c1F)C(C)C

102

{ "fragment_index": 0, "new_substring": "CC(C)[C@@H]&CC&", "old_substring": "C2(=O)C[C@H]5C" }

Can you make molecule CCN(CC)C(=O)C[C@@H](C)[NH2+][C@H](C)c1cccc(F)c1F less soluble in water? The output molecule should be similar to the input molecule.

CCN(CC)C(=O)CCC(C)(C)[NH2+][C@H](C)c1cccc(F)c1F

CCN(CC)C(=O)C[C@@H](C)[NH2+][C@H](C)c1cccc(F)c1F

CCN(CC)C(=O)CCC(C)(C)[NH2+][C@H](C)c1cccc(F)c1F

102

{ "fragment_index": 0, "new_substring": "C&(=O)CCC&(C)C", "old_substring": "C2(=O)C[C@H]5C" }

Can you make molecule CCN(CC)C(=O)C[C@@H](C)[NH2+][C@H](C)c1cccc(F)c1F less soluble in water? The output molecule should be similar to the input molecule.

CCN(CC)CC[C@H](Br)C[NH2+][C@H](C)c1cccc(F)c1F

CCN(CC)C(=O)C[C@@H](C)[NH2+][C@H](C)c1cccc(F)c1F

CCN(CC)CC[C@H](Br)C[NH2+][C@H](C)c1cccc(F)c1F

102

{ "fragment_index": 0, "new_substring": "C&C[C@H](Br)C&", "old_substring": "C2(=O)C[C@H]5C" }

Datasets:

MaIlz
/

replace_102

Dataset Card for "replace_102"