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values | premise stringlengths 111 17k | NCT_title stringlengths 18 299 | NCT_id stringlengths 11 11 | label stringclasses 2
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5,791 | 43 | A 27-year-old woman comes to the dermatology clinic with skin rash and oral ulcers. The rashes are mildly itchy. The patient has no other medical conditions and takes no medications. Vital signs are normal. On examination, there are pink papules symmetrically distributed over the anterior surfaces of the shins and a... | I went to the dermatologist because I had rashes on my skin and ulcers in my mouth. The rashes were not that itchy. I don't get it! I'm 27, I don't take medication, nor I don't have any other illnesses. My vitals were normal. My doc told me there were pink spots on the back of my throat. I'm heterosexual and have been ... | Inclusion Criteria:
1. Not having an active disease
2. Be between the ages of 18 and 45
3. Not using antibiotics in the last two weeks
4. Do not use inhaler treatments
5. Not to have an oral or salivary gland disease
6. One week after menstrual bleeding ... | Effect of Oral pH Changes on Smoking Desire | NCT04032236 | Contradiction |
634 | 3 | A 51-year-old man comes to the office complaining of fatigue and some sexual problems including lack of libido. The patient doesn't smoke or use any illicit drug. Blood pressure is 120/80 mm Hg and pulse is 70/min. Oxygen saturation is 99% on room air. BMI is 24 kg/m2. Skin examination shows increased pigmentation.... | I am 51 years old and I just came back from the doctor's office. I'm sick and tired of being that exhausted, reaching the point where me and my lovely wife are not touching each other anymore! I'm not smoking or doing drugs! My blood pressure was 120/80 mm Hg, and pulse was 70/min and my oxygen saturation 99%. My BMI i... | Inclusion Criteria:
- Patients with hemochromatosis, aged > 30 years, C282Y- homozygote, with serum-ferritin
=/> 1000 µg/L
- Patients aged > 18 years with verified low-risk or intermediate-1 risk of
myelodysplastic syndrome, with normal cytogenetics and serum-ferritin >... | Treatment of Iron Overload With Deferasirox (Exjade) in Hereditary Hemochromatosis and Myelodysplastic Syndrome | NCT01892644 | Contradiction |
957 | 4 | A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes. The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief. Past medical history is notable for hypertension and hypercholesteremia. ... | I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tyl... | Inclusion Criteria:
1. Written informed consent (IRB/IEC specific) has been obtained prior to initiation of
any protocol required procedures.
2. Male or female between 40 and 75 years of age. Females of childbearing potential must
have a negative urine pregnancy test at s... | A Single Center 2-way Crossover Study to Investigate the Mechanism of Action of Etoricoxib in Subjects With Osteoarthritis Knee Pain | NCT01619150 | Entailment |
5,355 | 40 | A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction. Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration. The patient has heavy menstrual cycles each month. She has no other medical problems and takes no medications... | I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical c... | Inclusion Criteria:
- Participants are female and have a uterus
- Participants are between the ages of 18 and 51 years at the time of consent
- Participants have heavy menstrual bleeding as evidenced by their symptoms of
subjective increased bleeding volume and desire to... | Quality of Life Outcomes for Ulipristal Acetate and Tranexamic Acid in the Management of Heavy Menstrual Bleeding | NCT03027973 | Contradiction |
1,768 | 11 | A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that show... | I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and m... | Inclusion Criteria:
- FD diagnosis by ROME IV criteria (one or more of bothersome symptoms like postprandial
fullness, early satiation, epigastric pain, and epigastric burning. It must include
criteria for postprandial distress syndrome and epigastric pain syndrome for the last
... | Multi-dimensional Clinical and Pathophysiological Profiles of Patients With Functional Dyspepsia and Effect of Gut Microbiota Manipulation Using Rifaximin for Its Treatment | NCT04302402 | Contradiction |
6,230 | 46 | The patient is a 38-year-old man with cough and body ache that started 3 days ago. He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within n... | I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my tem... | Inclusion Criteria:
- · Confirmed diagnosis of COVID-19 infection using a positive RT-PCR or a positive IgG
antibody test prior to or during hospitalization or,
· With a negative COVID-19 RT-PCR test but with symptoms of possible COVID-19
infection and:
- ... | The Evaluation of Hemostasis in Hospitalized COVID-19 Patients | NCT04493307 | Contradiction |
5,864 | 44 | A 48-year-old man comes to the office complaining of heartburn and acid reflux. He has taken over-the-counter antacids but sees no relief. Other medical history is unremarkable. The patient does not use tobacco, alcohol, or illicit drugs. Vital signs are within normal limits. BMI is 31 kg/m2. Physical examination... | I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old gu... | Inclusion Criteria:
- 19≤ age ≤ 75
- Esophago-Gastro-Duodenoscopy LA classification ≥ grade A
- Patients experienced heartburn or acid regurgitation within 7 days of screening day
- Patients understood the consents and purpose of this trial and signed consent form
... | Efficacy and Safety of HIP1601 Capsule | NCT04080726 | Contradiction |
3,852 | 30 | A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 chi... | I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 year... | Inclusion Criteria:
1. Patients suffered from chronic unilateral knee pain for more than 4 months and with
roentgenogram degenerative findings of grades 3 and 4 on the Kellgren-Lawrence
Classification of Osteoarthritis scale (meaning moderate to severe degrees of knee OA)
... | High Frequency Intensive Autologous PRP Injection and Genicular Nerve Blocks in Treating Knee Osteoarthritis | NCT04088045 | Entailment |
5,745 | 43 | A 27-year-old woman comes to the dermatology clinic with skin rash and oral ulcers. The rashes are mildly itchy. The patient has no other medical conditions and takes no medications. Vital signs are normal. On examination, there are pink papules symmetrically distributed over the anterior surfaces of the shins and a... | I went to the dermatologist because I had rashes on my skin and ulcers in my mouth. The rashes were not that itchy. I don't get it! I'm 27, I don't take medication, nor I don't have any other illnesses. My vitals were normal. My doc told me there were pink spots on the back of my throat. I'm heterosexual and have been ... | Inclusion Criteria:
- patients diagnosed with Behcet's Disease according to International Criteria for BD.
- patients with active oral ulcers.
- patients free from any visible oral lesions other than the oral ulcers of BD.
- patients who agreed to take the supplied interv... | Diode Laser Versus Topical Corticosteroids in Management of Oral Ulcers in Behcet's Disease | NCT03771768 | Contradiction |
4,713 | 35 | A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles. The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days. She is sexually active with her husband and... | I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of ... | Inclusion Criteria:
- The entire population of Manitoba is considered for inclusion.
Exclusion Criteria:
- Individuals less than or equal to 6 months of age;
- Having less than one year of insurance coverage before the enrolment period;
- Not registered with MH d... | A Database Study to Estimate the Risk of Multiple Sclerosis Following Vaccination With Arepanrix™ in Manitoba, Canada | NCT02367222 | Entailment |
5,966 | 44 | A 48-year-old man comes to the office complaining of heartburn and acid reflux. He has taken over-the-counter antacids but sees no relief. Other medical history is unremarkable. The patient does not use tobacco, alcohol, or illicit drugs. Vital signs are within normal limits. BMI is 31 kg/m2. Physical examination... | I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old gu... | Inclusion Criteria:
- Gastro-oesophageal reflux unresponsive to medical treatment, or those who had serious
complications (e.g. apnoea, aspiration pneumonia, oesophagitis)
Exclusion Criteria:
- Patients who had previous anti-reflux surgery, previous open abdominal surgery, ... | Comparison of Laparoscopic Nissen Versus Thal Fundoplication in Children | NCT01027975 | Contradiction |
6,171 | 46 | The patient is a 38-year-old man with cough and body ache that started 3 days ago. He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within n... | I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my tem... | Inclusion Criteria:
1. Male and female hospitalized patients between 45 and 80 years of age at time of
consent.
2. Clinical and laboratory diagnosis of COVID-19 infection. Patients must be positive for
the SARS-CoV-2 by Real-Time Reverse Transcriptase (RT)-PCR
... | LSALT Peptide vs. Placebo to Prevent ARDS and Acute Kidney Injury in Patients Infected With SARS-CoV-2 (COVID-19) | NCT04402957 | Contradiction |
1,157 | 6 | A 61-year-old man comes to the clinic due to nonproductive cough and progressive dyspnea. The patient's medical conditions include hypertension, hypercholesteremia and peptic ulcer disease. He smokes 2 packs of cigarettes daily for the past 30 years. On examination, there are decreased breath sounds and percussive d... | I am 61 and I had to go to the clinic because I couldn't stop coughing and I experienced some breath shortness. I suffer from hypertension and cholesterol and I also have a stomach ulcer. I should admit that I've been smoking 2 packs of cigarettes every day for the past 30 years. My doctor told me that my breath in my ... | Inclusion Criteria:
- Histologically or cytologically confirmed non-small cell lung cancer (NSCLC)
- Stage IIIB (with pleural effusion) or IV disease
- Measurable disease
- At least 1 lesion ≥ 2.0 cm by conventional techniques OR ≥ 1.0 cm by spiral CT
... | CCI-779 in Treating Patients With Stage IIIB (With Pleural Effusion) or Stage IV Non-Small Cell Lung Cancer | NCT00079235 | Contradiction |
903 | 4 | A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes. The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief. Past medical history is notable for hypertension and hypercholesteremia. ... | I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tyl... | Inclusion Criteria:
- Participants aged 40 years or older and diagnosed with mild or moderate knee
osteoarthritis(KOA) are eligible to participate in the study
- The following criteria are used for diagnosis of KOA:
- refractory knee pain for most days in the last m... | Acupuncture Treatment for Knee Osteoarthritis With Sensitive Acupoints and Tender Points | NCT03299439 | Entailment |
1,841 | 11 | A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that show... | I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and m... | Inclusion Criteria:
1. locally advanced (>T1) and/or nodal positive (N+) histologically proven adenocarcinoma
of the esophagogastreal junction (AEG I-III) or the stomach without distant metastases
(M0) and without infiltration of adjacent structures and organs
2. no previ... | 5-FU, Leucovorin, Oxaliplatin and Docetaxel (FLOT) Versus Epirubicin, Cisplatin and 5-FU (ECF) in Patients With Locally Advanced, Resectable Gastric Cancer | NCT01216644 | Entailment |
121 | 1 | A 19-year-old male came to clinic with some sexual concern. He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates. On physical examination, there is some pubic hair and poo... | I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me sm... | Inclusion Criteria:
- Diagnosed with hypogonadotropic hypogonadism, either congenital or acquired
- Have low circulating levels of testosterone
- Have low circulating levels of gonadotropins (follicle stimulating hormone [FSH];
luteinizing hormone)
- Presence... | A Study of the Efficacy and Safety of Corifollitropin Alfa (MK-8962) in Combination With Human Chorionic Gonadotropin (hCG) in Adult Men With Hypogonadotropic Hypogonadism (HH) (P07937) | NCT01709331 | Contradiction |
5,614 | 42 | A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively. On physical examination, the patient's height is in the 5th percentile of her age. Other findings include low-set ears, a high arched palate... | I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a we... | Inclusion Criteria:
- Before starting treatment, according to the medical history, clinical symptoms and
signs, GH stimulation test and imaging examination, patients are diagnosed as GHD.
- According to the height statistical data of Chinese children's physique development in
... | Phase IV Clinical Study of Pegylated Somatropin (PEG Somatropin) to Treat Growth Hormone Deficiency Children | NCT02314676 | Contradiction |
484 | 2 | A 32-year-old woman comes to the hospital with vaginal spotting. Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with ... | I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing... | Inclusion Criteria:
For All Females:
- Ages 18-45 years of age
- Able to provide written informed consent
- Normal Pap smear at screening or documentation of such within six months prior
- Regular monthly menses or amenorrhea due to hormonal contraceptive use
... | Study of UC-781 Vaginal Microbicide | NCT00132444 | Contradiction |
3,826 | 30 | A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 chi... | I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 year... | Inclusion Criteria:
Knee Osteoarthritis Subjects
1. Male or female 18-60 years of age
2. Confirmed diagnosis of knee osteoarthritis based on clinical and radiographic findings
3. Unilateral chronic knee pain >4 months
4. Imaging findings consistent with mild-moderate... | Impact of Mesenchymal Stem Cells in Knee Osteoarthritis | NCT03477942 | Entailment |
951 | 4 | A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes. The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief. Past medical history is notable for hypertension and hypercholesteremia. ... | I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tyl... | Inclusion Criteria:
- Clinical and radiographic diagnosis of osteoarthritis of the hand.
- Hand symptoms such as pain, aching and stiffness present across the prior six months.
- Willingness to use only Tylenol to relieve hand symptoms during the study.
- Primary spoken l... | Study of the Use of Laser Light to Treat Osteoarthritis of the Hand. | NCT00254111 | Entailment |
535 | 2 | A 32-year-old woman comes to the hospital with vaginal spotting. Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with ... | I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing... | Inclusion Criteria:
- women with thin endometrium
Exclusion Criteria:
- serum positive hepatitis B and C women
Female
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 40 Years | Use of Platelet Rich Plasma (PRP) for Improving Thin Endometrium | NCT03166345 | Contradiction |
2,785 | 20 | A 49-year-old man comes to the office because of the bulging in his groin. Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases. His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications... | I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to... | Inclusion Criteria:
- Patients scheduled for elective, inguinal hernia repair
- 18 years or older
- Male gender
- ASA physical classification system 1-3
- Informed consent
Exclusion Criteria:
- Patients with recurrent hernia, except patien... | Comparing Pain After Laparoscopic Hernia Repair Using Two Different Types of Mesh Fixation | NCT02467140 | Entailment |
3,026 | 22 | A 15-year-old boy with mild intellectual disability is brought to the office by his parents for a routine physical examination. The boy is going to a school for students with learning disabilities. The patient was adopted, and his immunizations are up to date. Review of the patient's medical records is notable for c... | My husband and I brought our 15-year-old son to the clinic for his routine exam. My son is going to school for special needs students. We adopted him a few years ago. His vaccinations are up to date. He already passed some chromosome testing and they found that he has a fragile X syndrome. The doctor told us that it co... | Inclusion Criteria:
1. A diagnosis of moderate IDD
2. Mobility independence
3. No secondary diagnosis of autism, nor sensory disabilities such as blindness or
deafness
4. Students had been studying at the school for at least one year prior to data
co... | Collaborative Consultation for Participation Among Students With IDD | NCT02797639 | Entailment |
6,492 | 47 | A 41-year-old woman comes to the dermatology clinic complaining of facial redness, especially on her forehead and cheeks. She noticed that the redness gets worse in the summer and after sun exposure. She is otherwise healthy. On physical examination, she has multiple papules and pustules present on her forehead, cheeks... | I'm 41, married with 2 lovely kids who are 5 and 9 years old. I have an IUD and I don't want to have more kids. I don't smoke or drink alcohol. I had to go to the dermatology clinic because I had terrible redness on my face, especially on my forehead and cheeks. It got worse in the summer and after being under the sun.... | Inclusion Criteria:
- Subjects who had provided written informed consent to participate in the study.
- Male or non-pregnant female aged ≥ 18 years with a clinical diagnosis of moderate to
severe facial rosacea, defined as the presence of: i. At least twelve and not more
... | Study to Evaluate the Safety and Efficacy of Topical Minocycline Gel in Patients With Papulopustular Rosacea | NCT03263273 | Entailment |
3,386 | 25 | A 50-year-old woman comes to the clinic with intermittent ear discharge and sense of hearing loss on her left ear. Past medical history is significant for obesity, hyperlipidemia, and diabetes mellitus. Her medications include Metformin, Atorvastatin and Vit D supplement. Vital signs are normal. BMI is 37. Otoscopy s... | I went to the clinic the other day because I had some fluid in my ear and I felt like I could not hear as well as I used to in my left ear. I'm a 50-year-old woman, and I have been obese for a while now. I have diabetes and cholesterol. I take some medication. I take metformin, atorvastatin, and vitamin D supplements. ... | Inclusion Criteria:
1. Controlled Type n Diabetes Mellitus (HbAlc <9%)
2. Baseline levels ofLDL-C >100 mg/dL
3. HDL-C <40 mg/dL
4. Triglycerides :::200mg/dL and :::500mg/dL
5. ALT and AST levels :::30%above the ULN with no active liver disease and CK :::50%above
... | Diabetes and Combined Lipid Therapy Regimen (DIACOR) Study | NCT00309712 | Contradiction |
1,984 | 11 | A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that show... | I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and m... | Inclusion Criteria:
- presenting for upper endoscopy for gastric indications
- gastric indications include upper abdominal pain dyspepsia abnormal gastric imaging
iron deficiency anemia gastric ulcer management of GI blood loss without active
bleeding reflux weight loss... | Narrow Band Imaging for Gastric Neoplasia | NCT02197351 | Entailment |
3,327 | 25 | A 50-year-old woman comes to the clinic with intermittent ear discharge and sense of hearing loss on her left ear. Past medical history is significant for obesity, hyperlipidemia, and diabetes mellitus. Her medications include Metformin, Atorvastatin and Vit D supplement. Vital signs are normal. BMI is 37. Otoscopy s... | I went to the clinic the other day because I had some fluid in my ear and I felt like I could not hear as well as I used to in my left ear. I'm a 50-year-old woman, and I have been obese for a while now. I have diabetes and cholesterol. I take some medication. I take metformin, atorvastatin, and vitamin D supplements. ... | Inclusion Criteria:
1. Adult aged 18-65 years.
2. Established diagnosis of stable sensorineural hearing loss (no changes of 10 dB or
more at any frequency) by standard audiometric measures for >6 months.
3. Documented medical history consistent with hearing loss being cause... | FX-322 in Sensorineural Hearing Loss | NCT03616223 | Contradiction |
2,235 | 14 | A 39-year-old man comes to the emergency department with an acute onset of severe left toe pain. The toe is red and exhibits swelling. The patient is not febrile, and does not remember any recent trauma. Medical history is not significant except for the similar attacks and the diagnosis of gouty arthritis. His medicat... | I'm a 39-year-old man and got admitted to the ER after an unbearable pain in my left toe. My toe was red and terribly swollen. I was still standing on my feet, not febrile and I don't remember hitting my head or anything. I don't have any special medical history, but I had been diagnosed with gout before. I take Lopuri... | Inclusion Criteria:
- Signed Informed consent
- Patient meeting the American College of Rheumatology/ European League Against
Rheumatism (ACR/EULAR) 2015 gout classification criteria
- History of ≥1 self-reported flares of gouty arthritis within 12 months
- C... | A Study to Evaluate Efficacy and Safety of Anakinra in the Treatment of Acute Gouty Arthritis | NCT03002974 | Entailment |
6,229 | 46 | The patient is a 38-year-old man with cough and body ache that started 3 days ago. He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within n... | I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my tem... | Inclusion Criteria:
1. Ages 18-75
2. Must be able to read and write in English or Spanish
3. Must be willing to try rapid COVID-19 test and self-collect a nasal swab sample in
both nostrils
4. Must be one of the following:
- Currently experiencin... | A Study To Evaluate The Performance of the Lucira Health All-In-One COVID-19 Test Kit vs Hologic Panther Fusion | NCT04720794 | Contradiction |
3,142 | 23 | A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn. The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness. She also reports occasional joint pain. Medical history... | I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to t... | Inclusion Criteria:
- Patients with type 2 diabetes mellitus suffering from xerostomia.
- Patients aged between 35 and 50 years old.
- Glycated hemoglobin less than 7% (28) .
- Duration of diabetes mellitus not less than 4 years and not more than 8 years.
Exclusi... | Malic Acid in Treatment of Xerostomia | NCT04756986 | Contradiction |
1,825 | 11 | A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that show... | I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and m... | Inclusion Criteria:
1. Age: 18 to75 years old;
2. Pathologically diagnosed with advanced gastric cancer (including adenocarcinoma of the
gastroesophageal junction) with measurable metastases outside the stomach (measuring ≥
10mm on spiral CT scan, satisfying the criteria ... | Study of Apatinib Tablets in the Treatment of Advanced or Metastatic Gastric Cancer | NCT02426034 | Entailment |
3,736 | 30 | A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 chi... | I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 year... | Inclusion Criteria:
- Patients of either sex with primary osteoarthritis of one or both knees fulfilling
diagnostic criteria for osteoarthritis knee laid down by American College of
Rheumatology.
- Patients also had to have a Kellgren-Lawrence (radiologic criterion) sco... | Electro-Acupuncture Treatment in Patients With Osteoarthritis Of The Knee (EATOAK) | NCT02299713 | Contradiction |
4,084 | 31 | A 25-year-old woman comes to the clinic with her roommate. The roommate says that the patient has twice fallen asleep while they were talking. The patient has regularly fallen asleep in the afternoon while reading or watching television but typically feels refreshed after a brief nap. She also reveals that she somet... | I brought my roommate to the clinic because she kept falling asleep when we were having a conversation. We're both 25 and usually healthy girls. She usually takes a nap in the afternoon while reading or watching TV, but usually, she is quite energetic afterward. She told me that she sometimes hears a voice before falli... | Inclusion Criteria:
- Patients that have a scheduled office visit with their primary care physician.
- Patients have to be Kaiser Permanente members
Exclusion Criteria:
- Non-English speaking patients unable to understand English to complete the surveys.
No condition on gend... | Validating the Use of a Subjectively Reported Sleep Vital Sign | NCT03018912 | Entailment |
5,622 | 42 | A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively. On physical examination, the patient's height is in the 5th percentile of her age. Other findings include low-set ears, a high arched palate... | I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a we... | Inclusion Criteria:
- Girls 10 through 14 years of age who are in good general health and have a BMI in the
85th to 95th percentile or greater than the 95th percentile
- Availability of a parent or guardian to ensure the child attends all monthly clinic
visits and who w... | Mood and Behavior Changes Among Overweight Adolescent Females | NCT00127374 | Contradiction |
4,021 | 30 | A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 chi... | I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 year... | Inclusion Criteria:
1. Primary osteoarthritis of the knee
2. Radiologic evidence of OA of the knee
3. On stable pain therapy with an oral or topical NSAID or acetaminophen
4. Experience a "moderate flare" of pain following washout of stable pain therapy
5. Able to ... | Exploratory Study of PENNSAID Gel to Treat Symptoms of Knee Osteoarthritis | NCT01119898 | Entailment |
1,445 | 9 | A 67-year-old woman comes to the clinic due to recent episode of choking, dysphagia, and cough. Her other medical problems include hypertension, dyslipidemia, and osteoarthritis. She does not smoke or use alcohol. She lives with her husband and she is able to do her own daily activities. She used to teach elementary ... | I'm a 67-year-old lady, and I went to the clinic due to nonstop choking, difficulty swallowing, and coughing. I also suffer from hypertension, cholesterol, and osteoarthritis. I do not smoke or drink alcohol. I live with my husband, and we are independent retired elementary school teachers. During the exam, my blood pr... | Inclusion Criteria:
- Patients with post-acute dysphagia (lesion occurring at least six weeks prior,
approximately),
- remaining in inpatient care for at least one month after the first moment of data
collection,
- 18 years of age or older,
- rec... | Poster on Dysphagia-specific Food Procedures: Usability and Impact | NCT03820791 | Contradiction |
3,555 | 26 | A 33-year-old woman comes to clinic complaining of progressive fatigue, decreased appetite, and 11-lb weight loss in the past 2 months. She uses levothyroxine because of the previously diagnosed Hashimoto disease. She has no other medical conditions and does not use tobacco, alcohol, or illicit drugs. Physical examin... | I went to the clinic because I was really suffering from fatigue and decreased appetite and I also lost 11 pounds over the past two months. I'm just 33 years old so that's not normal, especially for a woman. I take levothyroxine because I have been diagnosed with Hashimoto disease. I don't have any other medical condit... | Inclusion Criteria:
- Diagnosis of Addison's disease and/or diabetes mellitus type I or healthy control with
normal adrenal function and normal glucose regulation
- Age ≥ 18 years
- Ability to comply with the study protocol
- Capability to perform spiroergome... | Counterregulatory Hormone Production in Adrenal Insufficiency and Diabetes Type I | NCT01452893 | Entailment |
2,723 | 20 | A 49-year-old man comes to the office because of the bulging in his groin. Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases. His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications... | I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to... | Inclusion Criteria:
- surgeon determined need for inguinal hernia repair
Exclusion Criteria:
- < 18 years of age
- > 99 years of age
- medical indication for open repair
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the ... | Laparoscopic Versus Robot-assisted Inguinal Hernia Repair: A Single Institution Randomized Controlled Trial | NCT03133533 | Entailment |
3,039 | 22 | A 15-year-old boy with mild intellectual disability is brought to the office by his parents for a routine physical examination. The boy is going to a school for students with learning disabilities. The patient was adopted, and his immunizations are up to date. Review of the patient's medical records is notable for c... | My husband and I brought our 15-year-old son to the clinic for his routine exam. My son is going to school for special needs students. We adopted him a few years ago. His vaccinations are up to date. He already passed some chromosome testing and they found that he has a fragile X syndrome. The doctor told us that it co... | Inclusion Criteria:
- Subject has Fragile X syndrome with a molecular genetic confirmation of the full FMR1
mutation (>200 CGG repeats) or the other loss of function mutations of the FMR1 gene
(SNVs and deletions of the gene).
- Subject is a male or non-pregnant, non-la... | A Trial of Metformin in Individuals With Fragile X Syndrome (Met) | NCT03862950 | Entailment |
2,584 | 20 | A 49-year-old man comes to the office because of the bulging in his groin. Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases. His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications... | I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to... | Inclusion Criteria:
- occult inguinal or ventral hernia diagnosed in laparoscopic surgery
Exclusion Criteria:
- clinically diagnosed inguinal or ventral hernia
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18... | Follow-up of Symptomless Inguinal and Ventral Hernias | NCT04683367 | Contradiction |
5,841 | 44 | A 48-year-old man comes to the office complaining of heartburn and acid reflux. He has taken over-the-counter antacids but sees no relief. Other medical history is unremarkable. The patient does not use tobacco, alcohol, or illicit drugs. Vital signs are within normal limits. BMI is 31 kg/m2. Physical examination... | I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old gu... | Inclusion Criteria:
- Subject must be at least 18 years of age and at least the minimum Age of Majority
according to applicable State or Country Law and must be less than 75 years of age,
with a life expectancy > 3 years
- Subject is a suitable surgical candidate, i.e. ... | LINX Reflux Management System Clinical Study Protocol | NCT00776997 | Contradiction |
1,939 | 11 | A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that show... | I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and m... | Inclusion Criteria:
1. Patients with histologically documented gastric carcinoma (diffuse/intestinal
histotype) eligibile for R0.
1. Presurgical or intraoperative stage T3-T4 N0-N+ primary tumour (TNM 8 th).
2. Urgent presentation: perforation without purulent gen... | Prophylactic Surgery Plus HIPEC With CO2 in Patients Affected by Gastric Carcinoma.GOETH Study | NCT03917173 | Entailment |
5,189 | 39 | A 55-year-old white woman comes for a routine checkup. She has no significant medical history and does not use tobacco, alcohol, or illicit drugs. The patient's only medication is an over-the-counter multivitamin. Family history is notable for a hip fracture in her mother. Blood pressure is 130/80 mm Hg and pulse i... | I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse w... | Inclusion Criteria:
1. Fully informed, understood, voluntary participate, and the patient himself or guardian
agree to sign the written informed consent and patient be able to comply with the
protocol;
2. Aged from 50 years to 85 years, inclusive;
3. Spontaneou... | Clinical Efficacy and Safety Comparative Study Between CMAB807 Injection and Prolia® . | NCT04591275 | Entailment |
5,687 | 42 | A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively. On physical examination, the patient's height is in the 5th percentile of her age. Other findings include low-set ears, a high arched palate... | I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a we... | Inclusion Criteria:
All participants participating in GeNeSIS must be enrolled in the core study. Participants
for whom written consent to release information is provided may enter the core study if
they meet any of the following inclusion guidelines:
- Treatment with Humatrope for ... | Observational Study of Somatropin Treatment in Children | NCT01088412 | Entailment |
4,308 | 32 | A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia. The patient is sexually active with his wife and does not use any contraception methods. They have been trying to conceive for the past year with no success. The patient has a past medical history of recurrent p... | I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet ... | INCLUSION CRITERIA:
CF patients:
- Patient's written informed consent obtained prior to any study-related procedure;
- Male or female patient ≥ 18 years old with a confirmed historical diagnosis of cystic
fibrosis;
- Ability to provide a spontaneous sputum sampl... | A Clinical Study to Investigate Safety, Tolerability and Distribution of CHF 6333 After One or After Repeated Inhalation in Patients With Cystic Fibrosis (CF) and in Patients With Non Cystic Fibrosis (NCFB) Bronchiectasis | NCT04010799 | Entailment |
6,816 | 48 | A 20-year-old man comes to the emergency due to bleeding after a tooth extraction. The bleeding has persisted for approximately 30 minutes despite constant direct pressure. He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family histo... | I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove... | Inclusion Criteria:
- Patients (12-60 yr. old) with severe HA under FVIII concentrates prophylaxis will be
selected at the Haemostasis and Thrombosis Center of the Fondazione Policlinico
Universitario "A. Gemelli", IRCCS, Rome, Italy (FPG) and at the satellite site at the
... | PHYSICAL ACTIVITY AND FVIII CLEARANCE: RELEVANCE FOR PERSONALIZED THERAPY IN SEVERE HAEMOPHILIA A (PHYSEMO) | NCT04303936 | Entailment |
1,382 | 8 | A 7-month-old boy is brought to emergency by his parents due to irritability and inability to defecate for the past 3 days. The patient has had constipation and discomfort with bowel movements since birth. His symptoms worsened after eating semi-solid foods. Vital signs are normal. Abdominal examination shows diste... | My baby boy just turned 7 months old but my wife and I cannot get a hold of him! He has not been able to poop for 3 days! My poor little thing has been having constipation and bowel problems since birth. But since he ate some semi-solid food it has just been worse! The doctor said his vitals are normal but his belly is... | Inclusion Criteria:
- Hard or firm stools for 2 or less per week
- Age are from newborn to 3 years old
Exclusion Criteria:
- Children>3 years of age
- Patients presented severe inflammation or malnutrition, unconsciousness or perforation
of intestine... | A New Scoring System Improves Diagnostic Accuracy of Intestinal Dysganglionosis --a Prospective Study | NCT02216994 | Entailment |
394 | 2 | A 32-year-old woman comes to the hospital with vaginal spotting. Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with ... | I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing... | Inclusion Criteria:
- 1. Hysteroscopy examination confirms intrauterine adhesions, II -III according to the
American Fertility Society (AFS) classification of uterine adhesions;
- 2. Regular Menstrual cycles and menstruation is normal before abortion or curettage;
- 3. H... | Human Amniotic Epithelial Cells for Asherman's Syndrome | NCT03223454 | Contradiction |
3,277 | 23 | A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn. The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness. She also reports occasional joint pain. Medical history... | I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to t... | Inclusion Criteria:
- ability to understand and provide informed consent
- general good health male and female adults, were 20 years or older
- no pregnant woman
- had six caines-free maxillary anterior teeth without restorations on the labial
surfaces
... | Clinical Study to Evaluate of The Whitening Efficacy and Safety of REMEWHITE | NCT00978861 | Entailment |
941 | 4 | A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes. The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief. Past medical history is notable for hypertension and hypercholesteremia. ... | I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tyl... | Inclusion Criteria:
- symptomatic knee osteoarthritis according to the American College of Rheumatology
criteria for the classification and reporting of OA of the knee joint,
- predominance of self-reported pain over the medial aspect of the knee,
- radiographic evidence... | The Inclination of the Proximal Tibiofibular Joint Surface and Medial Compartment Knee Osteoarthritis | NCT03147495 | Entailment |
762 | 4 | A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes. The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief. Past medical history is notable for hypertension and hypercholesteremia. ... | I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tyl... | Inclusion Criteria:
- MMSE>21
- Chronic knee pain (VAS score>5)
- Right dominant
- Unilateral knee pain
Exclusion Criteria:
- Pain characteristics such as the presence of a rheumatologic disease other than knee
osteoarthritis, lumbar radi... | Effects of Action Observation Therapy on Pain and Brain Hemodynamics in Patients With Knee Osteoarthritis | NCT03792165 | Contradiction |
3,682 | 29 | A 57-year-old man comes to the emergency department due to constipation. His last bowel movement was 2 days ago. He complains of spending about 30 minutes once attempting to defecate. He also has lower back pain. There is no history of trauma. The pain is not relieved with over-the-counter pain medications. His vita... | I'm a 57 year-old-man, and I had to go to the ER because I couldn't go defecate. My last trip to the toilet was 2 days ago, and I tried too many times, during 30 min, to get my poop to get out. I also have terrible lower back pain. The doctor did not notice any trauma. I tried to get the pain away using over-the-counte... | Inclusion Criteria:
- The patient (or his/her guardian/parent/person-of-trust) was correctly informed about
the study
- A participating ER doctor has requested an imaging exam for the patient during one of
the trial observation periods (ie the "before" period or the "af... | Referral Guidelines for Imaging Exams: Impact on Exam Relevance and Associated Delays | NCT01785368 | Entailment |
5,626 | 42 | A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively. On physical examination, the patient's height is in the 5th percentile of her age. Other findings include low-set ears, a high arched palate... | I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a we... | - INCLUSION CRITERIA:
Girls with Turner syndrome will qualify to participate in this study if they meet the
following criteria:
Karyotype diagnosis compatible with Turner syndrome.
No treatment with estrogen, androgen or growth hormone exceeding twelve months, and no
treatmen... | The Effects of Hormones in Growth Hormone-Treated Girls With Turner Syndrome | NCT00001343 | Contradiction |
5,045 | 38 | A 60-year-old man comes to the clinic complaining of hand tremor that started few months ago. It is most bothering when he wants to drink from a glass or pour from a bottle. He does not smoke, but drinks occasionally. He recently started consuming more alcohol as his tremor subsides somewhat when he drinks small amoun... | I'm only a 60 years old man but I already suffer from shaky hands. It started a few months ago, and it really bothers me when I want to pour myself a glass or even while drinking. I don't smoke, but I drink alcohol from time to time. To be honest, I've been drinking a little more lately since it helps me with the shaki... | Inclusion Criteria:
- Patients must be ≥ 18 years
- The patient has a primary diagnosis of ET or ET plus confirmed by a movement disorder
neurologist;
- The patient previously underwent a GK thalamotomy (> 12 months ago);
- The tremor on the untreated side ne... | Bilateral Essential Tremor Treatment With Gamma Knife | NCT04748640 | Entailment |
4,323 | 32 | A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia. The patient is sexually active with his wife and does not use any contraception methods. They have been trying to conceive for the past year with no success. The patient has a past medical history of recurrent p... | I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet ... | Inclusion Criteria:
- Ability to produce semen sample
Exclusion Criteria:
- Cognitive impairment
- Inadequate language skills for informed consent
Male
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 60 Years | Modern Analyses of the Semen in Evaluating Male Fertility and Treatment Options of Male Infertility | NCT02932865 | Entailment |
3,467 | 25 | A 50-year-old woman comes to the clinic with intermittent ear discharge and sense of hearing loss on her left ear. Past medical history is significant for obesity, hyperlipidemia, and diabetes mellitus. Her medications include Metformin, Atorvastatin and Vit D supplement. Vital signs are normal. BMI is 37. Otoscopy s... | I went to the clinic the other day because I had some fluid in my ear and I felt like I could not hear as well as I used to in my left ear. I'm a 50-year-old woman, and I have been obese for a while now. I have diabetes and cholesterol. I take some medication. I take metformin, atorvastatin, and vitamin D supplements. ... | Inclusion Criteria:
1. Signed informed consent
2. Males or females aged 18 to 75 years. Female patients must be non-fertile. To be
considered as non-fertile, females must fulfil the following:
- Non-nursing and non-pregnant 12 months prior to enrolment
... | LDL-Cholesterol Lowering Effect of KB2115 as Add on to Statin | NCT00593047 | Entailment |
5,656 | 42 | A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively. On physical examination, the patient's height is in the 5th percentile of her age. Other findings include low-set ears, a high arched palate... | I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a we... | - INCLUSION CRITERIA:
Subjects will qualify for the overweight group for the dose-establishing studies 1 and 2
and main study) if they meet the following criteria:
1. Good general health.
2. Age greater than or equal to 7 and less than 15 years.
3. Tanner stage I, II o... | Free Fatty Acids, Body Weight, and Growth Hormones Secretion in Children | NCT01237041 | Contradiction |
2,700 | 20 | A 49-year-old man comes to the office because of the bulging in his groin. Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases. His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications... | I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to... | Inclusion Criteria:
- 50 patients selected and operated by the PI.
Exclusion Criteria:
- patients under the age of 18
- pregnancy
- BMI > 35
- recurrent groin hernia
- no Informed Consent
No condition on gender to be admitted to the trial.... | Robotic Utility for Surgical Treatment of Groin Hernias | NCT02975401 | Entailment |
2,546 | 18 | A 2-year-old boy is brought to the office by his parents due to a rash that started 1 week ago. A similar red, itchy rash on the cheeks, trunk, and arms has occurred intermittently since infancy. The patient has had a few upper respiratory infections but no major illnesses. Vaccinations are up to date, and he takes ... | I just brought my two-year-old son to the doctor's office because he had a rash for like one week. His rash was on the cheeks, the trunk, and his arms. He already had this before, and it keeps coming back from time to time to time. In the past, he had some respiratory infections but he has never been this sick. His vac... | Inclusion Criteria:
- Children aged 6-36 months
- diagnosis of Atopic Dermatitis according to SCORAD index
Exclusion Criteria
- Age < 6 months
- age > 36 months,
- skin infections,
- ichthyosis,
- food allergies,
- ... | Probiotic Lactobacillus Rhamnosus GG for Pediatric Atopic Dermatitis | NCT03863418 | Entailment |
2,630 | 20 | A 49-year-old man comes to the office because of the bulging in his groin. Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases. His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications... | I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to... | Inclusion Criteria:
- elective repair for a primary unilateral inguinal hernia OR
- elective repair for a recurrent unilateral inguinal hernia after non-mesh repair
Exclusion Criteria:
Male
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
| Evaluation of Mesh Integration and Mesh Contraction After Open Preperitoneal Inguinal Hernia Repair Using a Memory Ring Containing Device | NCT01622712 | Entailment |
2,294 | 15 | An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity m... | I brought my 8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weak... | Inclusion Criteria:
- diagnosis of DMD.
Exclusion Criteria:
- presence disorders in cognitive function that would prevent comprehension of the
experimental instruction.
Male
Accepts Healthy Volunteers
Subject must be at least 9 Years old.
Subject must be at most 34 Years | Analysis of a Virtual Reality Task in Patients With Duchenne Muscular Dystrophy | NCT02891434 | Contradiction |
1,411 | 9 | A 67-year-old woman comes to the clinic due to recent episode of choking, dysphagia, and cough. Her other medical problems include hypertension, dyslipidemia, and osteoarthritis. She does not smoke or use alcohol. She lives with her husband and she is able to do her own daily activities. She used to teach elementary ... | I'm a 67-year-old lady, and I went to the clinic due to nonstop choking, difficulty swallowing, and coughing. I also suffer from hypertension, cholesterol, and osteoarthritis. I do not smoke or drink alcohol. I live with my husband, and we are independent retired elementary school teachers. During the exam, my blood pr... | Inclusion Criteria:
1. Patients with a mean sitting systolic blood pressure (MSSBP) ≥ 140 mmHg measured on
selected arms after run-in period
2. Lipid levels measured after run-in period were:
- Group 1: hypertension + dyslipidemia only → fasting LDL-C ≥ 160 mg / dL
... | Clinical Trial to Evaluate the Efficacy and Safety of CKD-333 Tablet | NCT03583905 | Contradiction |
3,884 | 30 | A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 chi... | I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 year... | Inclusion Criteria:
- Ages 30-60
- Knee pain
- Radiographically confirmed knee osteoarthritis
Exclusion Criteria:
- Medical conditions contraindicating moderate aerobic exercise as determined through
prescreening questions, ie: heart condition, asthm... | Reaching Exercise Goals: Comparison of Exercise Means in Patients With Knee Osteoarthritis | NCT01359124 | Entailment |
5,872 | 44 | A 48-year-old man comes to the office complaining of heartburn and acid reflux. He has taken over-the-counter antacids but sees no relief. Other medical history is unremarkable. The patient does not use tobacco, alcohol, or illicit drugs. Vital signs are within normal limits. BMI is 31 kg/m2. Physical examination... | I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old gu... | Inclusion Criteria:
1. Any patient deemed a candidate for Sleeve Gastrectomy.
2. Age 18 years or older.
3. Body Mass Index equal or greater to 40 without comorbidities OR Body Mass Index equal
or greater than 35 with at least one obesity co-morbidity.
Exclusion Cri... | Hiatal Interrogation in Sleeve Gastrectomy | NCT03527810 | Contradiction |
3,998 | 30 | A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 chi... | I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 year... | Inclusion Criteria:
- Osteoarthritis of the knee requiring the therapy with non-steroidal anti-inflammatory
drugs (NSAIDs)
Exclusion Criteria:
none
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
| Study to Assess the Efficacy and Safety of Meloxicam vs. Diclofenac SR in Patients With Osteoarthritis of the Knee | NCT02183129 | Entailment |
3,325 | 25 | A 50-year-old woman comes to the clinic with intermittent ear discharge and sense of hearing loss on her left ear. Past medical history is significant for obesity, hyperlipidemia, and diabetes mellitus. Her medications include Metformin, Atorvastatin and Vit D supplement. Vital signs are normal. BMI is 37. Otoscopy s... | I went to the clinic the other day because I had some fluid in my ear and I felt like I could not hear as well as I used to in my left ear. I'm a 50-year-old woman, and I have been obese for a while now. I have diabetes and cholesterol. I take some medication. I take metformin, atorvastatin, and vitamin D supplements. ... | Inclusion Criteria:
Aims 1 and 2:
- Adult English speaking patients who are experienced users of Bone Anchored Implants
(BAIs) for the indication of either single sided deafness or conductive hearing loss.
- Experienced will be defined as greater than 6 months of device use... | Adhear Bone Conduction System | NCT03533686 | Contradiction |
4,886 | 37 | A 47-year-old man comes to the office due to weight gain and fatigue. He is not able to lift heavy objects or climb stairs. Family history is positive for DM type 2 and HTN in his father. Blood pressure is 165/90 mm Hg and pulse is 85/min. On physical examination, there is symmetric proximal muscle weakness of the u... | I'm a 47-year-old man. I went to the clinic because I had been gaining weight and had increased fatigue over the past few weeks. I was not able to lift heavy objects or even climb the stairs. My dad was diagnosed with type 2 diabetes and high blood pressure. During the exam, they took my blood pressure, which was 165/9... | Inclusion Criteria:
- ≥ 18 years of age.
- Has a documented diagnosis of ACTH-dependent, endogenous Cushing's syndrome and is
scheduled for curative surgery.
- Must be able to comprehend and sign an approved Informed Consent Form (ICF) and other
applicable s... | Biomarker Expression in Patients With ACTH-Dependent Cushing's Syndrome Before and After Surgery | NCT02922257 | Entailment |
1,956 | 11 | A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that show... | I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and m... | Inclusion Criteria:
- Participants must have unresectable or metastatic solid malignancy that is
histologically or cytologically confirmed to be one of the tumor types listed below:
- CRC
- Gastric adenocarcinoma
- GEJ adenocarcinoma
... | Tucatinib Plus Trastuzumab and Oxaliplatin-based Chemotherapy for HER2+ Gastrointestinal Cancers | NCT04430738 | Entailment |
5,566 | 42 | A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively. On physical examination, the patient's height is in the 5th percentile of her age. Other findings include low-set ears, a high arched palate... | I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a we... | Inclusion Criteria:
- To be included in the short stature group, subjects must have had short stature,
defined height less than -2 SD for gender and age or an abnormal growth velocity for
gender and age).
- To be included in the failure-to-thrive group, subjects must ha... | Ghrelin Levels in Children With Poor Growth | NCT01070173 | Contradiction |
6,746 | 48 | A 20-year-old man comes to the emergency due to bleeding after a tooth extraction. The bleeding has persisted for approximately 30 minutes despite constant direct pressure. He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family histo... | I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove... | Inclusion Criteria:
- Males or females >= 18 years of age.
- A diagnosis of hemophilia A, moderate (FVIII:C 0.01-0.04 U/ml) or mild (FVIII:C >=
0.05 U/ml); or a diagnosis of VWD, defined by a low VWF:RCo and past bleeding history.
- For those with VWD, an inability to us... | Efficacy and Safety of IL-11 in DDAVP Unresponsive | NCT00994929 | Contradiction |
6,337 | 46 | The patient is a 38-year-old man with cough and body ache that started 3 days ago. He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within n... | I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my tem... | Inclusion Criteria:
- The participant is a patient at TUKHS or has agreed to participate in a study approved
by the KUMC Human Research Protection Program (HRPP).
- The participant has a diagnosis of COVID-19 confirmed by COVID-19 PCR.
- Patient is 18 years of age or old... | COVID-19 Biorepository | NCT04568148 | Entailment |
3,574 | 27 | A 31-year-old woman comes to the office due to 3 days of rash on her left arm. The lesion is mildly pruritic but not painful. She is otherwise healthy and occasionally takes ibuprofen during the first few days of her menstrual period. Temperature is 37 C, blood pressure is 110/75 mm Hg, and pulse is 95/min. The lesi... | I went to the clinic because I had a rash on my left arm for three days, and the lesion started to be putrid, but it was not painful. I'm a 31-year-old healthy woman and the only medication I use is ibuprofen when I get my periods. They took my temperature, which turned out to be 37°C and took my blood pressure which w... | Inclusion Criteria:
- Clinical diagnosis of Erythema migrans
- Over the age of 18
- Signing an concent form after information in writing
Exclusion Criteria:
- Allergic to any of the three drugs in the study
- Under the age of 18
- Pregnanc... | Comparing 3 Antibiotic Regimes for Erythema Migrans in General Practice | NCT01368341 | Entailment |
5,308 | 39 | A 55-year-old white woman comes for a routine checkup. She has no significant medical history and does not use tobacco, alcohol, or illicit drugs. The patient's only medication is an over-the-counter multivitamin. Family history is notable for a hip fracture in her mother. Blood pressure is 130/80 mm Hg and pulse i... | I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse w... | Inclusion Criteria:
- History of fragility fracture OR
- High risk for fractures OR
- Very low BMD (T-score ≤ -2.5) OR
- Failed or intolerant to bisphosphonates
- Baseline serum levels of calcium, urate, ALP, PTH, creatinine and 25-hydroxyvitamin D
... | Teriparatide (PTH) and Bone Strength in Postmenopausal Women | NCT01155245 | Entailment |
3,139 | 23 | A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn. The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness. She also reports occasional joint pain. Medical history... | I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to t... | Inclusion Criteria:
- Males and females aged 21 to 55 years, diagnosed with primary or secondary Sjögren's
syndrome.
- Patients with a complaint of dry mouth based upon difficulty in speaking, swallowing,
a sensation of mouth or throat dryness, lip or tongue dryness, or... | Study of NGX267 Oral Capsules in Patients With Xerostomia Associated With Sjorgren's Syndrome | NCT00637793 | Contradiction |
3,805 | 30 | A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 chi... | I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 year... | Inclusion Criteria:
- - Both gender (female and male) patients
- Age between 40 - 60
- Knee osteoarthritis Grade I & II on Kellgren and Lawrence (K/L) criteria
- Prediagnosed case of knee OA as per the American College of Rheumatology (ACR).
Exclusion Criteria:
... | Mulligan Manual Therapy and Trunk Stabilization Exercises Versus Isometric Knee Strengthening on Knee Osteoarthritis | NCT04099017 | Entailment |
6,567 | 48 | A 20-year-old man comes to the emergency due to bleeding after a tooth extraction. The bleeding has persisted for approximately 30 minutes despite constant direct pressure. He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family histo... | I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove... | Inclusion Criteria:
- Aged 6 to 18 years
- Participants do not perform regular physical activity and sports.
- For hemophilia group who developed hemophilic arthropathy in at least one of the lower
limb joints due to severe hemophilia (total lower limb hemophilia joint h... | Evaluation of Static Postural Balance in Children With Hemophilia and Its Relationship With Joint Health | NCT04406519 | Contradiction |
5,158 | 39 | A 55-year-old white woman comes for a routine checkup. She has no significant medical history and does not use tobacco, alcohol, or illicit drugs. The patient's only medication is an over-the-counter multivitamin. Family history is notable for a hip fracture in her mother. Blood pressure is 130/80 mm Hg and pulse i... | I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse w... | Inclusion Criteria:
- Females, ages 45-65 years and post menopausal, as defined by a history of amenorrhea
for a minimum of 24 months and a serum FSH (follicle-stimulating hormone)
concentration of 25 mIU/mL (milli-International unit per milliliter) and negative
pregna... | Micromechanical Modeling Using Low Magnitude Mechanical Stimulation | NCT01921517 | Contradiction |
2,939 | 21 | A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year. Over the last few months, he has also noticed weakness in the right upper extremity. BP is 120/75, PR is 80 and temperature is 37 C. Reflex... | I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rat... | Inclusion Criteria:
1. ALS diagnosed as possible, laboratory supported probable, probable, or definite as
defined by revised El Escorial criteria.
2. ALSFRS-R Aggregate score of 37 or greater
3. No more than 24 months from diagnosis.
4. Able and willing to give i... | Multiple Doses of AT-1501-A201 in Adults With ALS | NCT04322149 | Entailment |
4,753 | 36 | A 47-year-old woman comes to the clinic complaining of dizziness. She also has occasional nausea and ringing in her right ear. The patient also has difficulty hearing while holding her phone to the left ear, although hearing in her right ear is normal. The dizziness improves spontaneously, and she feels fine between... | The other day, I had to go to the clinic due to severe dizziness. I'm 47 years old, and I've been suffering from nausea and ringing in my right ear. I also have difficulty hearing in my left ear while I hold my phone, even if my hearing in my right ear is normal. The dizziness just gets me all of a sudden but I don't h... | Inclusion Criteria:
- Patients diagnosed as Meniere's patients according to the 1995 AAO-HNS criteria are
included into this study.
Exclusion Criteria:
- Patients refused our prepared four kinds of treatments are excluded from this study.
No condition on gender to be admitt... | Stress Management Therapy for Meniere's Disease | NCT01099046 | Entailment |
6,496 | 47 | A 41-year-old woman comes to the dermatology clinic complaining of facial redness, especially on her forehead and cheeks. She noticed that the redness gets worse in the summer and after sun exposure. She is otherwise healthy. On physical examination, she has multiple papules and pustules present on her forehead, cheeks... | I'm 41, married with 2 lovely kids who are 5 and 9 years old. I have an IUD and I don't want to have more kids. I don't smoke or drink alcohol. I had to go to the dermatology clinic because I had terrible redness on my face, especially on my forehead and cheeks. It got worse in the summer and after being under the sun.... | Inclusion Criteria:
- Clinical diagnosis of moderate to severe rosacea, defined as the presence of at least
moderate erythema with telangiectasia and a minimum of two inflammatory lesions
Exclusion Criteria:
- Individuals with active symptoms of allergy (mild active seasona... | Assess the Ability of MetroGel 1% to Deliver Moisture to Facial Skin After a Single Application | NCT00436527 | Entailment |
3,774 | 30 | A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 chi... | I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 year... | Inclusion Criteria:
1. Subject has granted written informed consent.
2. Subject is at least 18 years of age.
3. Subject has knee pain with radiographic evidence of osteoarthritis in at least one
knee (including an x-ray within the previous 2 years).
4. Subject's ... | Osteoarthritis Knee Pain Relief Study of 0.25% 920-CGS-200 | NCT03124407 | Entailment |
3,521 | 26 | A 33-year-old woman comes to clinic complaining of progressive fatigue, decreased appetite, and 11-lb weight loss in the past 2 months. She uses levothyroxine because of the previously diagnosed Hashimoto disease. She has no other medical conditions and does not use tobacco, alcohol, or illicit drugs. Physical examin... | I went to the clinic because I was really suffering from fatigue and decreased appetite and I also lost 11 pounds over the past two months. I'm just 33 years old so that's not normal, especially for a woman. I take levothyroxine because I have been diagnosed with Hashimoto disease. I don't have any other medical condit... | Inclusion Criteria:
- Female patients with chronic primary adrenal insufficiency due to autoimmune
adrenalitis or bilateral adrenalectomy (disease duration at least 6 months)
- Age ≥ 18 years
- Patient´s written informed consent
- Ability to comply with the p... | Vaginal Prednisone Administration for Prevention of Adrenal Crisis | NCT02689960 | Contradiction |
6,838 | 49 | A 50-year-old woman comes to the clinic complaining of difficulty swallowing both liquids and solid foods, as well as occasional cough while eating. She also has difficulty lifting her arms above her head and getting up from a chair. The weakness seems to get worse gradually. The patient has no prior medical problems ... | I had to go to the clinic because of difficulty swallowing all kinds of food, liquid and solid. I also sometimes cough when I eat my dinner. At only 50 year old, I had some difficulties lifting up my arms and getting up from a chair! And it's only getting worse! I never had any medical issues in the past and I'm not un... | Inclusion Criteria:
- Has a diagnosis of polymyositis (PM)/ dermatomyositis (DM) made or confirmed by a
physician (such as a rheumatologist, neurologist, or dermatologist) experienced in
treatment of PM/DM at least 6 weeks prior to first dose of the study drug
- Has PM ... | A Study of Ustekinumab in Participants With Active Polymyositis and Dermatomyositis Who Have Not Adequately Responded to One or More Standard-of-care Treatments | NCT03981744 | Contradiction |
800 | 4 | A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes. The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief. Past medical history is notable for hypertension and hypercholesteremia. ... | I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tyl... | Key Inclusion criteria:
• Osteoarthritis of the hand
Key Exclusion Criteria:
- Other rheumatic disease, such as rheumatoid arthritis
- Active gastrointestinal ulcer during the last year
- Known allergy to analgesic drugs
No condition on gender to be admitted to the ... | Efficacy and Safety of Diclofenac Sodium Gel in Hand Osteoarthritis | NCT00171652 | Entailment |
6,142 | 46 | The patient is a 38-year-old man with cough and body ache that started 3 days ago. He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within n... | I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my tem... | Inclusion Criteria:
- Diagnosis of acute leukemia according to WHO criteria 2016 ≤ 5 years
- Diagnosis of a proven or probable SARS-CoV-2 infection according to the following
criteria:
1. Proven infection: positive Polymerase Chain Reaction (PCR) regardless of the
... | Multicentric Registry of Patients With Acute Leukemia Infected by COVID-19 | NCT04452604 | Contradiction |
3,699 | 30 | A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 chi... | I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 year... | Inclusion Criteria:
- All patients that are sent for knee MRI
- Patients over the age of 50 years old
- All patients will sign an informed consent for the study prior to the PET MRI
- Unilateral or Bilateral knee pain
- All patients were ambulatory pre-operati... | PET MRI for Evaluation of Knee Osteoarthritis in Patients With Bilateral Knee OA | NCT03174080 | Contradiction |
3,149 | 23 | A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn. The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness. She also reports occasional joint pain. Medical history... | I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to t... | Inclusion Criteria:
1. All recruited patients should be diagnosed with Sjogren's syndrome alone or in
association with other autoimmune conditions (rheumatic or not) based on their
rheumatologist opinion or have clinical and serological/imaging features which in the
opi... | Paediatric Sjögren Syndrome Cohort Study and Repository (PaedSSCoRe) | NCT04762108 | Contradiction |
1,896 | 11 | A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that show... | I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and m... | Inclusion Criteria:
- Patients age older than 18 years (including 18 years old);
- The primary lesion is located in the upper or middle third of the stomach, including
Siewert II type and Siewert III type adenocarcinoma of the esophagogastric junction;
- Pathologically c... | Laparoscopic Spleen-Preserving No. 10 Lymph Node Dissection for AGC | NCT03708783 | Entailment |
119 | 1 | A 19-year-old male came to clinic with some sexual concern. He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates. On physical examination, there is some pubic hair and poo... | I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me sm... | Inclusion Criteria:
- Men 60-80 years old
- Serum-testosterone levels <11.0 nmol/l
- Signed informed consent.
Exclusion Criteria:
- Prostate cancer
- Breast cancer
- Liver tumor/cancer
- Unstable angina
- Untreated ... | Older Men and Testosterone | NCT00119483 | Contradiction |
5,470 | 40 | A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction. Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration. The patient has heavy menstrual cycles each month. She has no other medical problems and takes no medications... | I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical c... | Inclusion Criteria:
- Male and female of any age, including infants, children, adolescent and adults
- Informed Consent obtained (parents should sign for patients < 18 y.o.)
- Previous Diagnosis of VWD3 (VWF Antigen: undetectable or <5 U/dL)
- Detailed information on inhe... | Type 3 Von Willebrand International Registries Inhibitor Prospective Study | NCT02460458 | Entailment |
5,365 | 40 | A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction. Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration. The patient has heavy menstrual cycles each month. She has no other medical problems and takes no medications... | I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical c... | Inclusion Criteria:
- Male and female subjects between 0 and <12 years of age
- Diagnosed with VWD Type 1, 2A, or 3
- Desmopressin acetate (DDAVP) treatment is ineffective, contraindicated, or not
available for subject
- von Willebrand factor: ristocetin cofa... | Study of Biostate® in Children With Von Willebrand Disease | NCT01213446 | Contradiction |
3,505 | 26 | A 33-year-old woman comes to clinic complaining of progressive fatigue, decreased appetite, and 11-lb weight loss in the past 2 months. She uses levothyroxine because of the previously diagnosed Hashimoto disease. She has no other medical conditions and does not use tobacco, alcohol, or illicit drugs. Physical examin... | I went to the clinic because I was really suffering from fatigue and decreased appetite and I also lost 11 pounds over the past two months. I'm just 33 years old so that's not normal, especially for a woman. I take levothyroxine because I have been diagnosed with Hashimoto disease. I don't have any other medical condit... | Inclusion Criteria:
- patients with Addison's disease
Exclusion Criteria:
- Type 1 diabetes
- malignant disease
- pregnant women
- cardiac disease
- lung disease
- neuromuscular diseases
- pharmacological treatment ... | Effect of Cortisol on Physical Exertion in Patients With Primary Adrenal Failure | NCT01847690 | Contradiction |
3,507 | 26 | A 33-year-old woman comes to clinic complaining of progressive fatigue, decreased appetite, and 11-lb weight loss in the past 2 months. She uses levothyroxine because of the previously diagnosed Hashimoto disease. She has no other medical conditions and does not use tobacco, alcohol, or illicit drugs. Physical examin... | I went to the clinic because I was really suffering from fatigue and decreased appetite and I also lost 11 pounds over the past two months. I'm just 33 years old so that's not normal, especially for a woman. I take levothyroxine because I have been diagnosed with Hashimoto disease. I don't have any other medical condit... | Inclusion Criteria:
- Volunteers will be in self-proclaimed good health
- Volunteers will be free of illness on the day of testing
- Volunteers will not be taking drug therapy.
- Patients will be free of intercurrent illness on the day of testing
- Patients wi... | Determination of Method-specific Normal Cortisol and Adrenal Hormone Responses to the Short Synacthen Test | NCT00851942 | Contradiction |
4,703 | 35 | A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles. The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days. She is sexually active with her husband and... | I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of ... | Inclusion Criteria:
- dysmenorrhea
- dyspareunia
- non cyclic lower abdominal pain
- hypermenorrhea
- menometrorrhaghia
- pain while compressing the Uterus during gyn exam
- Patient wants to participate
- Patient will receiv... | Diagnosis of Adenomyosis Using Ultrasound, Elastography and MRI | NCT04665414 | Entailment |
3,639 | 28 | A 23-year-old woman comes to the emergency department with a history of nosebleeds lasting for 1 hour. She has a history of heavy menses as well as occasional gum bleeding following dental procedures. Her mother also has a history of menorrhagia. Laboratory tests reveal increased bleeding time and slightly increased pa... | I had to rush to the ER because of a non-stop nosebleed that had been on for 1 hour. As a 23-year-old, I always had heavy periods, and sometimes, my gums would bleed after going to the dentist or brushing my teeth. I thought that it was not very alarming since my mom also had heavy periods. I did some lab tests that sh... | Inclusion Criteria:
- Patient with bleeding history sent to the Hemophilia Treatment Center in Dijon or
Nantes University Hospital with abnormal bleeding score (>3 in men and >5 in women
- Patient who has provided a signed consent to participate at this study and for blood
... | Performance Evaluation of Von Willebrand:Collagen-Binding Assays to Diagnose Von Willebrand Factor Deficiency in Patients With Increased Risk of Bleeding | NCT02792205 | Entailment |
3,588 | 28 | A 23-year-old woman comes to the emergency department with a history of nosebleeds lasting for 1 hour. She has a history of heavy menses as well as occasional gum bleeding following dental procedures. Her mother also has a history of menorrhagia. Laboratory tests reveal increased bleeding time and slightly increased pa... | I had to rush to the ER because of a non-stop nosebleed that had been on for 1 hour. As a 23-year-old, I always had heavy periods, and sometimes, my gums would bleed after going to the dentist or brushing my teeth. I thought that it was not very alarming since my mom also had heavy periods. I did some lab tests that sh... | Inclusion Criteria:
- Women with menorrhagia
- 18-49 years of age
- Regularly occurring menstrual periods
Exclusion Criteria:
- History or presence of clinically significant disease or abnormalities that may
confound the study
- History o... | Efficacy and Safety of XP12B in Women With Menorrhagia | NCT00401193 | Contradiction |
6,267 | 46 | The patient is a 38-year-old man with cough and body ache that started 3 days ago. He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within n... | I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my tem... | Subject Inclusion Criteria:
An individual must meet the criteria below to be eligible.
- Individual is Illumina US personnel (eg, employee, contractor, consultant) and was
invited to participate in the study.
- Individual is 18 years or older at the time of consent.
... | Evaluation of the COVIDSeq Test in Saliva Specimens From COVID-19 Asymptomatic Illumina Personnel | NCT04561089 | Contradiction |
5,775 | 43 | A 27-year-old woman comes to the dermatology clinic with skin rash and oral ulcers. The rashes are mildly itchy. The patient has no other medical conditions and takes no medications. Vital signs are normal. On examination, there are pink papules symmetrically distributed over the anterior surfaces of the shins and a... | I went to the dermatologist because I had rashes on my skin and ulcers in my mouth. The rashes were not that itchy. I don't get it! I'm 27, I don't take medication, nor I don't have any other illnesses. My vitals were normal. My doc told me there were pink spots on the back of my throat. I'm heterosexual and have been ... | Inclusion Criteria:
- Biopsy confirmed symptomatic oral lichen planus: WHO histological criteria in
combination with clinical appearance will be used for diagnosis
- Patients who had symptoms such as burning sensation, pain
- Patients not on any immunosuppressive or immu... | Efficacy of Purslane in Treatment of Oral Lichen Planus | NCT00746772 | Contradiction |
5,917 | 44 | A 48-year-old man comes to the office complaining of heartburn and acid reflux. He has taken over-the-counter antacids but sees no relief. Other medical history is unremarkable. The patient does not use tobacco, alcohol, or illicit drugs. Vital signs are within normal limits. BMI is 31 kg/m2. Physical examination... | I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old gu... | Inclusion Criteria:
1. Patients with typical symptoms of GERD with symptomatic response to PPI therapy for ≥
3 months
2. Hill's grade II and III of the gastroesophageal junction
3. One of the following abnormalities in the objective assessment 3.1. Excessive acid
... | Antireflux Mucosectomy (ARMS) for Treatment of Gastroesophageal Reflux | NCT04194723 | Contradiction |
2,834 | 21 | A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year. Over the last few months, he has also noticed weakness in the right upper extremity. BP is 120/75, PR is 80 and temperature is 37 C. Reflex... | I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rat... | Inclusion Criteria:
- ALS diagnosed patients according to Airlie House criteria
- treated with riluzole
- respiratory quotient (RQ) of patients in indirect calorimetry (IC) should be in
between 0.7 and 0.87
Exclusion Criteria:
-
No condition on gender t... | Resting Energy Expenditure Equations in Amyotrophic Lateral Sclerosis, Creation of a ALS-specific Equation | NCT03378375 | Entailment |
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