id int64 3 7.01k | topic_id int64 1 50 | statement_medical stringclasses 50
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values | premise stringlengths 111 17k | NCT_title stringlengths 18 299 | NCT_id stringlengths 11 11 | label stringclasses 2
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5,291 | 39 | A 55-year-old white woman comes for a routine checkup. She has no significant medical history and does not use tobacco, alcohol, or illicit drugs. The patient's only medication is an over-the-counter multivitamin. Family history is notable for a hip fracture in her mother. Blood pressure is 130/80 mm Hg and pulse i... | I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse w... | Inclusion Criteria:
- Age > 18 years
- Presence of:
- at least one and at most two acute VCF (< 6 weeks) at levels caudate to T4, confirmed
with physical examination and radiographic imaging
- if timing of the fracture is unclear, the following criteria are r... | Vertebroplasty In The Treatment Of Acute Fracture Trial - The VITTA Trial | NCT02370628 | Entailment |
3,038 | 22 | A 15-year-old boy with mild intellectual disability is brought to the office by his parents for a routine physical examination. The boy is going to a school for students with learning disabilities. The patient was adopted, and his immunizations are up to date. Review of the patient's medical records is notable for c... | My husband and I brought our 15-year-old son to the clinic for his routine exam. My son is going to school for special needs students. We adopted him a few years ago. His vaccinations are up to date. He already passed some chromosome testing and they found that he has a fragile X syndrome. The doctor told us that it co... | Inclusion Criteria:
- Diagnosis of mile to moderate IDD as determined by a Community Service Provider
operating in Kansas under the auspices of a Community Developmental Disability
Organization (CDDO)
- Able to understand and give informed consent
- If there... | Weight Loss and Maintenance for Individuals With Intellectual Developmental Disabilities (IDD) | NCT01724905 | Entailment |
133 | 1 | A 19-year-old male came to clinic with some sexual concern. He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates. On physical examination, there is some pubic hair and poo... | I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me sm... | Inclusion Criteria:
- Total testosterone level <10.4 nanomoles per liter (nmol/L) [300 nanograms per
deciliter (ng/dL)] at screening
- Presents with 1 or more of the following symptom(s) of ejaculatory dysfunction:
delayed ejaculation, anejaculation, decreased force of ... | A Study of Ejaculatory Dysfunction in Men With Low Testosterone Levels | NCT01419236 | Contradiction |
3,001 | 22 | A 15-year-old boy with mild intellectual disability is brought to the office by his parents for a routine physical examination. The boy is going to a school for students with learning disabilities. The patient was adopted, and his immunizations are up to date. Review of the patient's medical records is notable for c... | My husband and I brought our 15-year-old son to the clinic for his routine exam. My son is going to school for special needs students. We adopted him a few years ago. His vaccinations are up to date. He already passed some chromosome testing and they found that he has a fragile X syndrome. The doctor told us that it co... | Inclusion Criteria:
- Male between the ages of 16-50 years old at the time of consent
- Diagnosis of full mutation FXS.
- Stable on any psychoactive medication for at least 4 weeks before receiving study
drug, including antidepressants, stimulants, antipsychotics, and mo... | Metformin in Patients With Fragile X | NCT04141163 | Contradiction |
732 | 4 | A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes. The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief. Past medical history is notable for hypertension and hypercholesteremia. ... | I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tyl... | Inclusion Criteria:
- Candidates must meet ALL of the following:
1. Voluntary signature of the Institutional Review Board/Research Ethics Board
approved Informed Consent,
2. Male or female subjects between the ages of 30 to 75 years,
3. Body ... | Subchondroplasty® Knee RCT | NCT03112200 | Contradiction |
1,728 | 10 | A 19-year-old girl comes to the clinic due to a left wrist mass. She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns. Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient n... | I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penli... | Inclusion Criteria:
- Speaking the Dutch language
Exclusion Criteria:
- No serious cognitive impairments
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
| Basic Care Revisited_Communication for Patient Participation | NCT02401919 | Entailment |
6,241 | 46 | The patient is a 38-year-old man with cough and body ache that started 3 days ago. He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within n... | I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my tem... | Inclusion Criteria:
- 1. Adults ≥18 years old requiring hospital admission for COVID-19
2. COVID-19 confirmed by either*:
- A positive swab (using RT-PCR)
- OR based on a high level of clinical probability confirmed by the presence of typical
symptoms and compatibl... | The CASCADE Study - Measures of Complement Activation and Inflammation in Patients With Covid-19 | NCT04453527 | Contradiction |
2,129 | 13 | A 24-year-old man comes to the office complaining of infertility. He and his wife have been trying to conceive for the last 18 months. Medical records of his wife showed no abnormalities. The patient doesn't smoke and takes no medications. Height is 185 cm and weight is 77 kg. Heart and lung sounds are normal. Th... | I'm only a 24 year old man but I’m already struggling with infertility. I went to a clinic with my wife the other day because we've been trying to have a baby for at least 18 months. The medical records of my wife are totally normal. For me I don't smoke or take any medication. I'm 185 cm and 77 kg. Everything was norm... | Inclusion Criteria:
- infertile males
Exclusion Criteria:
- suergery
Male
No healthy subjects accepted to join the trial.
Subject must be at least 15 Years old.
Subject must be at most 60 Years | Semen Analysis and Insight Into Male Infertility | NCT04178954 | Entailment |
6,937 | 50 | A 70-year-old man comes to the office accompanied by his wife. The patient has experienced progressive memory loss over the last years. He needs help with some of his routine activities, such as paying bills. The patient's wife says, "He used to be such an independent person, but now he needs help with many things, ... | I am a 70-year-old man, and I paid a visit to the doctor with my wife the other day. I noticed that I tend to forget small things and that my memory has decreased over the past few years. I even ask my wife to help me out with my daily routine. I used to be the one paying the bills, but now she has to give me a hand. M... | Inclusion Criteria:
- Capable of giving signed informed consent which includes compliance with the
requirements and restrictions listed in the informed consent form and protocol. If the
subject is incapable of giving or signing informed consent, the subject must have a
... | Safety of SNK01 in Subjects With Mild Cognitive Impairment (MCI) and Alzheimer's Disease | NCT04678453 | Entailment |
2,699 | 20 | A 49-year-old man comes to the office because of the bulging in his groin. Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases. His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications... | I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to... | Inclusion Criteria:
- Unilateral primary inguinal hernia presenting for repair
Exclusion Criteria:
- Recurrent repairs
- Females
- Bilateral repairs
- Repairs done with other operative procedures
Male
Accepts Healthy Volunteers
Subject must be at leas... | The Economic Impact of Four Varieties of Mesh Inguinal Hernia Repair- a Double-Blinded, Prospective, Randomized Trial | NCT00416364 | Entailment |
4,649 | 35 | A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles. The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days. She is sexually active with her husband and... | I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of ... | Inclusion Criteria:
laparoscopic assisted vaginal hysterectomy leiomyoma adenomyosis-
Exclusion Criteria:
other types of operations other types of gynecological disease-
Female
No healthy subjects accepted to join the trial.
Subject must be at least 21 Years old.
Subject must be at most 80 Ye... | Health-Related QoL Among Women Receiving Hysterectomy in NTUH | NCT00155870 | Entailment |
124 | 1 | A 19-year-old male came to clinic with some sexual concern. He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates. On physical examination, there is some pubic hair and poo... | I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me sm... | Inclusion Criteria:
- Age: 50 or older
- Total Testosterone <=280 ng/dl
- Subsyndromal depressive disorder: either dysthymia or minor depression (per DSM IV and
DSM IV appendix)
Exclusion Criteria:
- PSA >=3.0
- Klinefelter's syndrome
... | The Effect of Testosterone on Mood and Quality of Life | NCT00202462 | Contradiction |
5,617 | 42 | A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively. On physical examination, the patient's height is in the 5th percentile of her age. Other findings include low-set ears, a high arched palate... | I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a we... | Inclusion Criteria:
- Chronological Age ≥ 3.0 years and ≤ 10.0 (girls) and ≤ 11.0 (boys).
- Pre-pubertal status: Absent breast development in girls, testicular volume < 4.0 mL in
boys.
- Diagnosis of GHD as documented by two or more GH stimulation test results ≤ 10.0
... | Versartis Long-Acting Growth Hormone in Children Compared to Daily rhGH | NCT02339090 | Contradiction |
6,854 | 49 | A 50-year-old woman comes to the clinic complaining of difficulty swallowing both liquids and solid foods, as well as occasional cough while eating. She also has difficulty lifting her arms above her head and getting up from a chair. The weakness seems to get worse gradually. The patient has no prior medical problems ... | I had to go to the clinic because of difficulty swallowing all kinds of food, liquid and solid. I also sometimes cough when I eat my dinner. At only 50 year old, I had some difficulties lifting up my arms and getting up from a chair! And it's only getting worse! I never had any medical issues in the past and I'm not un... | Patients age greater than or equal to 18 years.
Patients with a diagnosis of definite or probable dermatomyositis by criteria of Bohan et.
al., with either active rash typical of dermatomyositis, history of rash typical of
dermatomyositis, or Gottron's papules.
Patients with a manual m... | Safety and Effectiveness of h5G1.1-mAb for Dermatomyositis | NCT00005571 | Entailment |
2,704 | 20 | A 49-year-old man comes to the office because of the bulging in his groin. Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases. His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications... | I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to... | Inclusion Criteria:
- Inguinal hernia
Exclusion Criteria:
- Recurrences, child
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 16 Years old.
Subject must be at most 90 Years | A New Approach in Inguinal Hernia Repair: Double Repair. A Prospective, Randomized, Controlled Clinical Trial | NCT01003509 | Entailment |
3,645 | 28 | A 23-year-old woman comes to the emergency department with a history of nosebleeds lasting for 1 hour. She has a history of heavy menses as well as occasional gum bleeding following dental procedures. Her mother also has a history of menorrhagia. Laboratory tests reveal increased bleeding time and slightly increased pa... | I had to rush to the ER because of a non-stop nosebleed that had been on for 1 hour. As a 23-year-old, I always had heavy periods, and sometimes, my gums would bleed after going to the dentist or brushing my teeth. I thought that it was not very alarming since my mom also had heavy periods. I did some lab tests that sh... | Inclusion Criteria:
- Patients and healthy volunteers with non-opposition to participate in the evaluation
- Healthy volunteers : from 18 years to 70 years
- Patients : minimum age limit 18 years - no maximum age limit
Exclusion Criteria:
- Healthy volonteers wit... | Determination of Fibrin Activity in Plasma on STA-R® Prototype | NCT02856789 | Entailment |
2,636 | 20 | A 49-year-old man comes to the office because of the bulging in his groin. Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases. His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications... | I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to... | Inclusion Criteria:
- 18-80 years old male patients, with a symptomatic inguinal hernia that can be
diagnosed by clinical examination. Primary and unilateral hernia. The operation
performed at a day surgery unit.
Exclusion Criteria:
- female
- bilat... | Inguinal Hernia Operation and Postoperative Pain | NCT03734224 | Entailment |
6,401 | 46 | The patient is a 38-year-old man with cough and body ache that started 3 days ago. He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within n... | I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my tem... | Inclusion Criteria:
- COVID-19 cases
- Oxygen saturation > 93%
- Age >18 years
Exclusion Criteria:
- Patients <18 years,
- patients with Oxygen saturation < 93%, patients with
- Diabetes mellitus or
- heart failure,
... | Clarithromycin Versus Azithromycin in Treatment of Mild COVID-19 Infection | NCT04622891 | Entailment |
1,032 | 4 | A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes. The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief. Past medical history is notable for hypertension and hypercholesteremia. ... | I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tyl... | Inclusion Criteria:
- Age 45 to 80 years old, inclusive
- Clinical diagnosis of osteoarthritis in one target knee based on the following
American College of Rheumatology (ACR) criteria:
1. Knee Pain
2. At least 1 of 3:
- Age > 50... | Study of OLT1177 Gel to Treat Moderate to Severe OA Knee Pain | NCT02104050 | Entailment |
5,869 | 44 | A 48-year-old man comes to the office complaining of heartburn and acid reflux. He has taken over-the-counter antacids but sees no relief. Other medical history is unremarkable. The patient does not use tobacco, alcohol, or illicit drugs. Vital signs are within normal limits. BMI is 31 kg/m2. Physical examination... | I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old gu... | Key Inclusion Criteria:
1. Patient seeks consultation for lack of satisfactory symptom response to once daily
PPIs.
2. Age≥ 21 years old.
3. Abnormal distal esophageal pH determined by total % time pH <4 or DeMeester Score.
Testing to be completed off GERD medi... | The CALIBER Study Randomized Controlled Trial of LINX Versus Double-Dose Proton Pump Inhibitor Therapy for Reflux Disease | NCT02505945 | Contradiction |
2,058 | 12 | A 47-year-old man comes to the office for routine checkup. He is complaining of chronic cough and occasional but progressive dyspnea. Other medical conditions include hypertension and osteoarthritis. The patient smokes a pack of cigarettes daily and does not use alcohol or illicit drugs. He used to be a construction... | I'm a 47-year-old former construction worker. I'm a man and I smoke a pack of cigs a day but I don't drink or do drugs. I went to my routine checkup because I've been coughing so much lately. I also had shortness of breath and it got worse over time. I already suffer from hypertension and osteoarthritis. My doctor foun... | Inclusion Criteria:
- IPF patients diagnosed by multidisciplinary discussion
Exclusion Criteria:
- Other interstitial lung diseases except for IPF
- connective tissue disease-related ILD
- exposure-related ILD
No condition on gender to be admitted to the trial.
N... | Korean Idiopathic Pulmonary Fibrosis Registry | NCT04160715 | Contradiction |
72 | 1 | A 19-year-old male came to clinic with some sexual concern. He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates. On physical examination, there is some pubic hair and poo... | I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me sm... | DISEASE CHARACTERISTICS:
- Newly diagnosed high-grade glioma, including the following subtypes:
- Anaplastic astrocytoma
- Anaplastic oligodendroglioma
- Glioblastoma multiforme
- Requires dexamethasone at a dose of > 4 mg/day to control symptom... | Testosterone Gel in Preventing Weakness Caused by Steroid Therapy in Men With Glioma | NCT00631137 | Contradiction |
3,838 | 30 | A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 chi... | I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 year... | Inclusion Criteria:
- Patients referred from a general practitioner in the North Denmark Region to the
orthopaedic clinic at Aalborg University Hospital
- Patients with painful OA in hip- or knee joint.
Exclusion Criteria:
- Patients unable to answer the questio... | RCT Measuring the Effect of the ERVIN Software | NCT04332055 | Entailment |
5,739 | 43 | A 27-year-old woman comes to the dermatology clinic with skin rash and oral ulcers. The rashes are mildly itchy. The patient has no other medical conditions and takes no medications. Vital signs are normal. On examination, there are pink papules symmetrically distributed over the anterior surfaces of the shins and a... | I went to the dermatologist because I had rashes on my skin and ulcers in my mouth. The rashes were not that itchy. I don't get it! I'm 27, I don't take medication, nor I don't have any other illnesses. My vitals were normal. My doc told me there were pink spots on the back of my throat. I'm heterosexual and have been ... | Inclusion Criteria:
- Is a male or a non-pregnant, non-lactating female.
- Has a history and clinical presentation consistent with a diagnosis of Behçet's
Disease and meets International Study Group criteria (Appendix B).
- Has a history of oral ulcers for at least 12 mo... | Low Dose Interferon Alpha Treatment for Oral Ulcers of Behcet's Disease | NCT00483184 | Contradiction |
3,120 | 23 | A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn. The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness. She also reports occasional joint pain. Medical history... | I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to t... | Inclusion Criteria:
- Patients with vernal keratoconjunctivitis,
- mild or moderate : clinical score >3 and <= 14, calculated from 4 major symptoms
(itching, tearing, photophobia, foreign body sensation) and 6 major clinical signs
(conjunctival erythema, conjunctival ch... | Study of the Clinical and Biological Efficacity of NAAXIA SINE® in Vernal Keratoconjunctivitis | NCT00357019 | Contradiction |
1,902 | 11 | A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that show... | I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and m... | Inclusion Criteria:
1. Age: more than 18 years old;
2. Histologically confirmed advanced or metastatic adenocarcinoma of gastric cancer(AGC)
, including adenocarcinoma of the gastroesophageal junction;
3. At least one measurable and evaluable disease based on response evalu... | Clinical Trial of Apatinib Reverses Chemotherapy-Resistance of Patients With Advanced Gastric Cancer | NCT02697838 | Entailment |
5,087 | 39 | A 55-year-old white woman comes for a routine checkup. She has no significant medical history and does not use tobacco, alcohol, or illicit drugs. The patient's only medication is an over-the-counter multivitamin. Family history is notable for a hip fracture in her mother. Blood pressure is 130/80 mm Hg and pulse i... | I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse w... | Inclusion Criteria:
- women with osteoporosis (T score lower than -2.5)
- women whom had suffered from non specific low back pain for the last 3 months or more.
Exclusion Criteria:
- history of operations in the spine
- history of cancer or neurologic disease
... | Comparison of a Weight Bearing and a Non-weight Bearing Protocol on Osteoporotic Women With Chronic Low Back Pain | NCT03747289 | Contradiction |
3,712 | 30 | A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 chi... | I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 year... | Inclusion Criteria:
- 50 years old or older with knee osteoarthritis
- knee pain without joint effusion confirmed by ultrasonography
Exclusion Criteria:
- the presence of knee joint effusion determined using US
- a history of knee injury or surgery
- ... | Effects of Joint Effusion on Quadriceps Muscle | NCT01314820 | Contradiction |
4,289 | 32 | A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia. The patient is sexually active with his wife and does not use any contraception methods. They have been trying to conceive for the past year with no success. The patient has a past medical history of recurrent p... | I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet ... | Inclusion Criteria:
- Signed informed consent available before any study specific tests or procedures are
performed
- Patients must be at least 18 years of age at time of inclusion (i.e. upon signature of
informed consent)
- Patient diagnosed with Cystic Fib... | Early Signs of Efficacy Study With Riociguat in Adult Homozygous Delta F508 Cystic Fibrosis Patients | NCT02170025 | Entailment |
6,741 | 48 | A 20-year-old man comes to the emergency due to bleeding after a tooth extraction. The bleeding has persisted for approximately 30 minutes despite constant direct pressure. He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family histo... | I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove... | Inclusion Criteria:
- Patients in different age groups with superficial soft tissue lesions
Exclusion Criteria:
- If the patient undergo previous operations at the same mass that could change the
criteria of that mass or if the mass is recurrent at the same site.
No conditi... | Doppler Ultrasound in Characterization of Superficial Soft Tissue Masses | NCT03171857 | Contradiction |
2,318 | 15 | An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity m... | I brought my 8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weak... | DMD Subject Inclusion Criteria
- Affected subjects must be male and between the ages of 2 and 30
- Affected subjects between the ages of 2 and 4 must have a diagnosis of DMD confirmed
by at least one the following OR have an older male sibling that meet at least one of
... | Longitudinal Study of the Natural History of Duchenne Muscular Dystrophy (DMD) | NCT00468832 | Entailment |
4,874 | 37 | A 47-year-old man comes to the office due to weight gain and fatigue. He is not able to lift heavy objects or climb stairs. Family history is positive for DM type 2 and HTN in his father. Blood pressure is 165/90 mm Hg and pulse is 85/min. On physical examination, there is symmetric proximal muscle weakness of the u... | I'm a 47-year-old man. I went to the clinic because I had been gaining weight and had increased fatigue over the past few weeks. I was not able to lift heavy objects or even climb the stairs. My dad was diagnosed with type 2 diabetes and high blood pressure. During the exam, they took my blood pressure, which was 165/9... | Inclusion Criteria:
- The patient is under consultation in the department of metabolic and endocrine
disorders at the CHU Nimes for diagnosis or follow-up of hypercortisol assessment
- The patient must be a member or beneficiary of a health insurance plan
Exclusion Criteria... | Discriminant Capacity and Thresholds of Salivary Cortisol in Chemiluminescence in the Diagnosis of Hypercorticisms | NCT03974789 | Entailment |
830 | 4 | A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes. The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief. Past medical history is notable for hypertension and hypercholesteremia. ... | I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tyl... | Key Inclusion Criteria:
1. A clinical diagnosis of Osteoarthritis (OA) of the knee or hip based on the American
College of Rheumatology criteria with radiologic evidence of OA (K-L score ≥2 for the
index joint) at the screening visit
2. Moderate-to-severe pain in the inde... | To Assess the Patients' Ability to Self-Administer Fasinumab | NCT03491904 | Entailment |
3,934 | 30 | A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 chi... | I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 year... | Inclusion Criteria:
1. Males or Females 40 years and older
2. According to the clinical diagnosis standard of the American College of Rheumatology
(ACR), someone, diagnosed as a single/both sides of osteoarthritis, who corresponds to
over 3 conditions of followings.
... | Clinical Trial of YY1201 for Treatment of Osteoarthritis of the Knee | NCT02554552 | Entailment |
6,724 | 48 | A 20-year-old man comes to the emergency due to bleeding after a tooth extraction. The bleeding has persisted for approximately 30 minutes despite constant direct pressure. He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family histo... | I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove... | Inclusion Criteria:
- Severe hemophilia A (< 1% FVIII)
- 30-45 years of age
- Previously treated subject (> 100 Exposure days to any FVIII)
- On-demand therapy with any FVIII
Exclusion Criteria:
- No history of inhibitor
- No planned elect... | BAY14-2222 Prophylaxis and Joint Function Improvement (Adults) | NCT00586521 | Contradiction |
2,477 | 17 | A 67-year-old man comes to the clinic with slowly worsening vision in both eyes. He is not able to drive at night, as the symptoms are worse at night. His pupils are normal in diameter both in the light and darkness. Other medical history is unremarkable. Ocular examination shows loss of the red reflex and blurry vis... | I am a 67 years-old man, and I haven't been able to drive at night due to my vision getting worse. My vision is not the best in general, but night makes it even worse. The ophthalmologist told me that my pupils were normal. However, I have slow reflexes and blurry vision. My acuity test came back with 50/100 vision in ... | Inclusion Criteria:
- Have normal vision
- Are far-sighted or near-sighted
- Have no eye diseases Subjects aged 18 and over, who have refractive errors ranging
from +5.0 to -5.0 and/or who have eye disease will be included in the study.
No condition on gender to be admit... | Comprehensive Evaluation of Visual Function | NCT00894192 | Contradiction |
3,531 | 26 | A 33-year-old woman comes to clinic complaining of progressive fatigue, decreased appetite, and 11-lb weight loss in the past 2 months. She uses levothyroxine because of the previously diagnosed Hashimoto disease. She has no other medical conditions and does not use tobacco, alcohol, or illicit drugs. Physical examin... | I went to the clinic because I was really suffering from fatigue and decreased appetite and I also lost 11 pounds over the past two months. I'm just 33 years old so that's not normal, especially for a woman. I take levothyroxine because I have been diagnosed with Hashimoto disease. I don't have any other medical condit... | Inclusion Criteria:
- Primary or secondary adrenal insufficiency, Healthy matched controls, acute or
unstable health conditions age 18 or older
Exclusion Criteria:
- Diabetes, Tertiary adrenal insufficiency
No condition on gender to be admitted to the trial.
Accepts Healthy... | Circadian Function and Cardio-metabolic Risk in Adrenal Insufficiency | NCT03000231 | Entailment |
5,916 | 44 | A 48-year-old man comes to the office complaining of heartburn and acid reflux. He has taken over-the-counter antacids but sees no relief. Other medical history is unremarkable. The patient does not use tobacco, alcohol, or illicit drugs. Vital signs are within normal limits. BMI is 31 kg/m2. Physical examination... | I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old gu... | Inclusion Criteria:
1. Male or Female aged ≥ 20 years
2. Reflux esophagitis with erosion or ulceration confirmed by endoscopic exam.
3. Refractory reflux esophagitis to PPIs standard treatment as follows
1. Ongoing heartburn symptom with or without these GERD-related sym... | The Study to Evaluate Efficacy and Safety of Newrabell® Tab.(Rabeprazole Sodium) 10mg b.i.d in Refractory GERD | NCT01860482 | Contradiction |
4,116 | 32 | A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia. The patient is sexually active with his wife and does not use any contraception methods. They have been trying to conceive for the past year with no success. The patient has a past medical history of recurrent p... | I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet ... | Inclusion Criteria:
- Females age < 42 with an indication for IVF
- Females with lowest AMH level 1.2 ng/mL or higher
- Females with FSH < 13 mIU/mL
- Sperm obtained via Surgical retrieval (any type) for IVF only
- Use of comprehensive chromosome screening (CC... | Fresh Vs Frozen Surgical Sperm in IVF | NCT03361982 | Contradiction |
3,986 | 30 | A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 chi... | I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 year... | Inclusion Criteria:
[Visit 1, 2 Inclusion Criteria]
1. Males or Females 40 years and older
2. According to the clinical diagnosis standard of the American College of Rheumatology
(ACR), someone, diagnosed as a single/both sides of osteoarthritis, who corresponds to
... | Clinical Trial of YYD302 (Phase3) for Treatment of Osteoarthritis of the Knee | NCT03561779 | Entailment |
337 | 2 | A 32-year-old woman comes to the hospital with vaginal spotting. Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with ... | I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing... | Inclusion Criteria:
- Age of women <43 years at the time of stimulated IVF
- Replacing early cleavage embryos or blastocysts after thawing
Exclusion Criteria:
- Requiring hormonal replacement cycles
- Use of donor oocytes or embryos
- Undergoing preim... | Oral Dydrogesterone as Luteal Phase Support in Natural Cycle FET | NCT03859921 | Contradiction |
3,950 | 30 | A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 chi... | I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 year... | Inclusion Criteria:
- Patients > 18 years with diagnosis of OA or RA according to the criteria of the
American College of Rheumatology (ACR).
Exclusion Criteria:
- Patients with precedents of fractures; carrying patients of chronic diseases who limit
them in th... | Mexican Initiative of Patients With Osteoarthritis and Rheumatoid Arthritis (IMPACTAR) | NCT02124031 | Entailment |
5,361 | 40 | A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction. Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration. The patient has heavy menstrual cycles each month. She has no other medical problems and takes no medications... | I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical c... | Inclusion Criteria:
- Signed informed consent
- Age 18 years or older
- Absence of significant medical conditions
- Patients with healthy or effectually treated periodontal conditions
- Candidate for single tooth replacement in the anterior maxilla
Ex... | Dimensional Soft and Hard Tissue Alterations Following Single Tooth Extraction in the Anterior Maxilla - A Prospective Clinical Study | NCT02403700 | Contradiction |
727 | 4 | A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes. The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief. Past medical history is notable for hypertension and hypercholesteremia. ... | I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tyl... | Inclusion Criteria:
- Subject has been taking an NSAID at least 15 of the past 30 days for index knee pain
- Grades 2 or 3 OA as defined by the Kellgren and Lawrence Grading System of the medial
tibiofemoral joint (joint space narrowing in the medial compartment > lateral
... | Measuring Gait And Self-Reported Pain In Patients With Osteoarthritis Of The Knee Using Placebo/Oxycodone/Celecoxib. | NCT00484718 | Contradiction |
4,689 | 35 | A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles. The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days. She is sexually active with her husband and... | I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of ... | Inclusion Criteria:
1. 18 years of age or older
2. Pelvic pain and/or abnormal uterine bleeding. (this is specific for Arm. 1 of this
study)
3. If you have had or are scheduled to have both a pelvic MRI (magnetic resonance
imaging) and a pelvic ultrasound with ... | What Are we Missing? Diagnosing Uterine Adenomyosis Using Ultrasound Elastography | NCT01992718 | Entailment |
6,168 | 46 | The patient is a 38-year-old man with cough and body ache that started 3 days ago. He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within n... | I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my tem... | Inclusion Criteria:
- Covid-19 patient admitted to the infectious unit
Exclusion Criteria:
- patients who do not agree to sign informed consent, or participating in other studies.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject... | Monitoring COVID-19 Patients' Lung Fluid Using Impedance Technique | NCT04406493 | Contradiction |
6,433 | 47 | A 41-year-old woman comes to the dermatology clinic complaining of facial redness, especially on her forehead and cheeks. She noticed that the redness gets worse in the summer and after sun exposure. She is otherwise healthy. On physical examination, she has multiple papules and pustules present on her forehead, cheeks... | I'm 41, married with 2 lovely kids who are 5 and 9 years old. I have an IUD and I don't want to have more kids. I don't smoke or drink alcohol. I had to go to the dermatology clinic because I had terrible redness on my face, especially on my forehead and cheeks. It got worse in the summer and after being under the sun.... | Inclusion Criteria:
- 18 years or older
- Skin types I, II, III
- No previous laser or IPL treatment for the condition
Exclusion Criteria:
- Younger than 18 years old
- Skin types IV, V, or VI
- Pregnant or lactating women
- Pr... | Pulsed Dye Laser and Intense Pulsed Light (IPL) for the Treatment of Telangiectasia and Skin Redness | NCT00206921 | Entailment |
1,857 | 11 | A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that show... | I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and m... | Inclusion Criteria:
- Adult females and males over 45 years of age with dyspeptic symptoms (epigastric pain,
bloating and epigastric discomfort)
Exclusion Criteria:
- Patients who require surgery or immediate follow-up treatment for major symptoms,
including he... | Gastropanel for Gastric Atrophy and Cancer Risk Assessment | NCT02114411 | Entailment |
1,905 | 11 | A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that show... | I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and m... | Inclusion Criteria:
- diagnostic gastroscopy, age over 18, danish speaking,
Exclusion Criteria:
- use of beta blocking or any other heart rate modulating drug, antithyroid drugs
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject m... | Stress Response Using Thin and Standard Size Endoscopy. | NCT00273130 | Entailment |
1,120 | 5 | A 23-year-old man comes to the emergency department following an episode of syncope. He was working out when he felt dizzy and passed out without head injury. He has had 3 other episodes of light-headedness over the last year, all happening during physical activity. He never had this experience while resting. He has ... | I'm 23, and I got admitted to the ER because I fainted all of a sudden. I was in the gym, working out, when all of a sudden, I just got dizzy and passed out. Hopefully, I didn't hit my head. It's not my first time having that kind of dizziness at the gym, never when I'm chilling at home tho. I don't have any special me... | Inclusion Criteria:
- Patients' selection criteria and enrollment plan:
We will enroll subjects from either cardiovascular clinics or inpatients from the National
Cheng Kung University Hospital from 2018 to 2021 after the signature of inform consent from
patients and their families.... | Artificial Intelligence With Deep Learning and Genes on Cardiovascular Disease | NCT03877614 | Entailment |
1,117 | 5 | A 23-year-old man comes to the emergency department following an episode of syncope. He was working out when he felt dizzy and passed out without head injury. He has had 3 other episodes of light-headedness over the last year, all happening during physical activity. He never had this experience while resting. He has ... | I'm 23, and I got admitted to the ER because I fainted all of a sudden. I was in the gym, working out, when all of a sudden, I just got dizzy and passed out. Hopefully, I didn't hit my head. It's not my first time having that kind of dizziness at the gym, never when I'm chilling at home tho. I don't have any special me... | Inclusion Criteria:
- Patients with a typical or atypical hypertrophic cardiomyopathy (HCM) confirmed by
imaging modalities (echo and MRI) and/or genetic tests or a relative history of HCM
- Left ventricular obstruction during exercise on treadmill (above 50 mmHg)
- Posi... | Hypertrophic Cardiomyopathy Symptom Release by BX1514M | NCT02590809 | Entailment |
6,179 | 46 | The patient is a 38-year-old man with cough and body ache that started 3 days ago. He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within n... | I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my tem... | Inclusion Criteria:
1. Ambulatory male or female outpatients ≥ 50 years of age who have laboratory-confirmed
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection as determined
by qualitative PCR (reverse transcriptase (RT)-PCR), or other commercial or public
... | A Study to Evaluate the Safety and Efficacy of C19-IG 20% in SARS-CoV-2 Infected Asymptomatic Ambulatory Outpatients | NCT04847141 | Contradiction |
626 | 3 | A 51-year-old man comes to the office complaining of fatigue and some sexual problems including lack of libido. The patient doesn't smoke or use any illicit drug. Blood pressure is 120/80 mm Hg and pulse is 70/min. Oxygen saturation is 99% on room air. BMI is 24 kg/m2. Skin examination shows increased pigmentation.... | I am 51 years old and I just came back from the doctor's office. I'm sick and tired of being that exhausted, reaching the point where me and my lovely wife are not touching each other anymore! I'm not smoking or doing drugs! My blood pressure was 120/80 mm Hg, and pulse was 70/min and my oxygen saturation 99%. My BMI i... | Inclusion Criteria:
- adult patients of > or equal 18 years
- genetic hemochromatosis
- undergoing a therapeutic blood withdrawal
- health insured
- non-obese (body mass index <30Kg/m²)
Exclusion Criteria:
- pregnancy
- transth... | Respiratory Variations For Assessing Blood Withdrawal | NCT03066414 | Contradiction |
1,311 | 7 | A 3-year-old girl is brought to the clinic by her parents for assessment of her short stature. Physical examination reveals short limbs and a relatively large head. She has a flat nasal bridge and a small midface. The girl's father exhibits similar physical features; however, her mother looks normal. The genetic testin... | I just brought my little 3-year-old girl to the clinic to have her checked up by the doctor. I was worried sick because she was smaller than her classmates. The lovely doctor performed a physical exam and she told me that she has short limbs and a larger head. My girl also has a flat nasal bridge and a small midface. M... | Inclusion Criteria:
- Children and adolescents with Noonan's syndrome with a height < -2 SD and no
progressive cardiopathy
Exclusion Criteria:
- Age < 3 years
- Height ≥ -2 SD
The above information is not intended to contain all considerations relevant ... | Effect of MAXOMAT ® on the Growth of Small Children to NOONAN's Syndrome | NCT00452725 | Contradiction |
6,801 | 48 | A 20-year-old man comes to the emergency due to bleeding after a tooth extraction. The bleeding has persisted for approximately 30 minutes despite constant direct pressure. He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family histo... | I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove... | Inclusion Criteria:
- Ability to provide written informed consent
- Age ≥18 years
- Presence of a nonsense mutation as the sole disease-causing mutation in the FVIII or
FIX gene
- At least 20 prior treatments with FVIII or FIX concentrates
- Willi... | Study of Ataluren (PTC124) in Hemophilia A and B | NCT00947193 | Entailment |
6,712 | 48 | A 20-year-old man comes to the emergency due to bleeding after a tooth extraction. The bleeding has persisted for approximately 30 minutes despite constant direct pressure. He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family histo... | I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove... | Inclusion Criteria:
1. All children ages 6 months - 18 years with hemophilia A or B
2. Hemophilia subjects with and without a history of hemarthroses including target joints
( joint of interest) and joints without documented bleeds( control joints)
3. Hemophilia subjects wi... | Ultrasonography in Hemophilic Joint Disease and Serum Markers | NCT02634918 | Contradiction |
5,315 | 39 | A 55-year-old white woman comes for a routine checkup. She has no significant medical history and does not use tobacco, alcohol, or illicit drugs. The patient's only medication is an over-the-counter multivitamin. Family history is notable for a hip fracture in her mother. Blood pressure is 130/80 mm Hg and pulse i... | I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse w... | Inclusion Criteria:
- Healthy ambulatory postmenopausal (≥ 5 years) women from 50 to 85 years of age
(inclusive) with a diagnosis of osteoporosis
- The women are to have a bone mineral density (BMD) T score ≤ -2.5 and > -5.0 at the
lumbar spine or hip (femoral neck) by ... | Study to Evaluate the Safety and Efficacy of BA058 (Abaloparatide) for Prevention of Fracture in Postmenopausal Women | NCT01343004 | Entailment |
5,671 | 42 | A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively. On physical examination, the patient's height is in the 5th percentile of her age. Other findings include low-set ears, a high arched palate... | I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a we... | Inclusion Criteria:
- Body Mass Index ≥ 25 - ≤ 34.9 kg/m2.
- Waist Circumference ≥ 80 cms.
- Non-smoker.
- BP ≤ 140/90 mm Hg
- FBS ≤ 125 mg/dl
- Hb ≥ 11 g/ dl
- Can abstain from strenuous exercise and alcohol for at least 48 hours.
... | Aerobic Fitness in Overweight and Obese Individuals | NCT03854786 | Contradiction |
422 | 2 | A 32-year-old woman comes to the hospital with vaginal spotting. Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with ... | I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing... | Inclusion Criteria:
- 1) Between 18 and 49 years of age (at screening), inclusive.
- 2) Willing and able to provide written informed consent.
- 3) Healthy, based on medical history, vital signs, physical examination, urinalysis,
laboratory evaluations for genital infecti... | Study to Evaluate the Safety of Griffithsin in a Carrageenan Gel in Healthy Women | NCT02875119 | Contradiction |
1,779 | 11 | A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that show... | I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and m... | Inclusion Criteria:
Patients undergoing upper endoscopy Motivation to participate in the study Signed consent
Exclusion Criteria:
Known gastric cancer Unwillingness or inability to co-operate
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at lea... | Surveillance of Patients With Precancerous Lesions of the Stomach | NCT03250091 | Contradiction |
5,275 | 39 | A 55-year-old white woman comes for a routine checkup. She has no significant medical history and does not use tobacco, alcohol, or illicit drugs. The patient's only medication is an over-the-counter multivitamin. Family history is notable for a hip fracture in her mother. Blood pressure is 130/80 mm Hg and pulse i... | I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse w... | Inclusion Criteria:
- Postmenopausal women between the ages of 46 and 80（cessation of menses for 12 months
for any reason）
- Subjects with osteoporosis diagnosed according to the World Health Organization (WHO)
criteria：they had a BMD T-score of -2.5 or less at the spin... | Generic Zoledronic Acid Versus Original Zoledronic Acid in Postmenopausal Osteoporotic Women | NCT03158246 | Entailment |
5,608 | 42 | A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively. On physical examination, the patient's height is in the 5th percentile of her age. Other findings include low-set ears, a high arched palate... | I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a we... | Inclusion Criteria:
- Women treated in an endocrinology centre specialising in hyperandrogenism at the
university hospital of University Federal of Minas Gerais (Belo Horizonte, Minas
Gerais, Brazil)
- The patients were of reproductive age (range: 18-45 years)
... | Predictive Equations for Resting Energy Expenditure | NCT02435888 | Contradiction |
1,323 | 7 | A 3-year-old girl is brought to the clinic by her parents for assessment of her short stature. Physical examination reveals short limbs and a relatively large head. She has a flat nasal bridge and a small midface. The girl's father exhibits similar physical features; however, her mother looks normal. The genetic testin... | I just brought my little 3-year-old girl to the clinic to have her checked up by the doctor. I was worried sick because she was smaller than her classmates. The lovely doctor performed a physical exam and she told me that she has short limbs and a larger head. My girl also has a flat nasal bridge and a small midface. M... | Inclusion Criteria:
- Histologically or cytologically confirmed solid tumor malignancy that is advanced or
metastatic (Stage IIIB or IV) or is surgically unresectable.
- Radiographically measurable disease (per RECIST v1.1 or RANO for primary brain
tumors).
-... | Efficacy and Safety of Pemigatinib in Participants With Solid Tumors With FGFR Mutations or Translocations (FIGHT-208) | NCT04003623 | Contradiction |
1,535 | 10 | A 19-year-old girl comes to the clinic due to a left wrist mass. She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns. Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient n... | I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penli... | Inclusion Criteria:
- children with moderate to severe asthma living in homes with non EPA-certified
woodstove used for heating.
Exclusion Criteria:
-
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 1... | Indoor Woodsmoke PM and Asthma | NCT00807183 | Contradiction |
4,796 | 36 | A 47-year-old woman comes to the clinic complaining of dizziness. She also has occasional nausea and ringing in her right ear. The patient also has difficulty hearing while holding her phone to the left ear, although hearing in her right ear is normal. The dizziness improves spontaneously, and she feels fine between... | The other day, I had to go to the clinic due to severe dizziness. I'm 47 years old, and I've been suffering from nausea and ringing in my right ear. I also have difficulty hearing in my left ear while I hold my phone, even if my hearing in my right ear is normal. The dizziness just gets me all of a sudden but I don't h... | Inclusion Criteria:
- The patient suffering from vertigo and dizziness for at least 1 month and
- The ability to walk independently or do their routine tasks will be included in the
study.
- Patients should be capable to complete the questionnaire without any help.
... | Translation of Dizziness Handicap Inventory Scale Into Local Languages of Pakistan | NCT04849078 | Entailment |
753 | 4 | A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes. The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief. Past medical history is notable for hypertension and hypercholesteremia. ... | I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tyl... | Inclusion criteria:
- Age 70+
- Fall in the last 12 months before screening (with or without a fracture)
- Living at home (community-dwelling)
- Men or women
- Mobile with or without walking aid - have to be able to use public transportation to
at... | Zurich Disability Prevention Trial | NCT01017354 | Contradiction |
5,686 | 42 | A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively. On physical examination, the patient's height is in the 5th percentile of her age. Other findings include low-set ears, a high arched palate... | I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a we... | Inclusion Criteria:
- Diagnosed with Turner's Syndrome through chromosome analysis
- The chronological age: 2≤AGE≤12
- The yearly growth rate should be less than 6cm; the bone age should be equal or less
than 12; the height ≤ 10th percentile for the heights of their agem... | A Clinical Study to Assess the Efficacy and Safety of DA-3002 | NCT01813630 | Entailment |
3,393 | 25 | A 50-year-old woman comes to the clinic with intermittent ear discharge and sense of hearing loss on her left ear. Past medical history is significant for obesity, hyperlipidemia, and diabetes mellitus. Her medications include Metformin, Atorvastatin and Vit D supplement. Vital signs are normal. BMI is 37. Otoscopy s... | I went to the clinic the other day because I had some fluid in my ear and I felt like I could not hear as well as I used to in my left ear. I'm a 50-year-old woman, and I have been obese for a while now. I have diabetes and cholesterol. I take some medication. I take metformin, atorvastatin, and vitamin D supplements. ... | Inclusion Criteria:
- Sensorineural hearing loss
- Veteran-adult onset of hearing
- English as first language
- Eligible for VA issued hearing aids
- Eligible to receive care at one of the three participating VA sites: Nashville,
Tennessee, Mounta... | Evaluation of Open-canal Behind-the-Ear Hearing Aids and Traditional In-the-ear Hearing Aids. | NCT00727909 | Contradiction |
5,812 | 44 | A 48-year-old man comes to the office complaining of heartburn and acid reflux. He has taken over-the-counter antacids but sees no relief. Other medical history is unremarkable. The patient does not use tobacco, alcohol, or illicit drugs. Vital signs are within normal limits. BMI is 31 kg/m2. Physical examination... | I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old gu... | Main Inclusion Criteria:
- Patients who completed ALTANA Pharma study BY1023/FK3006 (long-term clinical trial
regarding efficacy and tolerability of Pantoprazole in patients not responding to
treatment with H2-receptor antagonists or omeprazole)
- Written informed conse... | Long-term Pantoprazole Trial in Patients With Symptoms of Chronic Acid Peptic Complaints (BY1023/VMG-708) | NCT00261300 | Contradiction |
3,671 | 29 | A 57-year-old man comes to the emergency department due to constipation. His last bowel movement was 2 days ago. He complains of spending about 30 minutes once attempting to defecate. He also has lower back pain. There is no history of trauma. The pain is not relieved with over-the-counter pain medications. His vita... | I'm a 57 year-old-man, and I had to go to the ER because I couldn't go defecate. My last trip to the toilet was 2 days ago, and I tried too many times, during 30 min, to get my poop to get out. I also have terrible lower back pain. The doctor did not notice any trauma. I tried to get the pain away using over-the-counte... | Inclusion Criteria:
- At Visit 1 (study entry) patients must have a medical history and physical and
neurological examinations that support a clinical diagnosis of acute low back pain
that is felt down to the lower leg below the knee with the onset no longer than 30
da... | NUCYNTA (Tapentadol Immediate Release) Versus Oxycodone Immediate Release in the Treatment of Acute Low Back Pain | NCT00986180 | Contradiction |
194 | 1 | A 19-year-old male came to clinic with some sexual concern. He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates. On physical examination, there is some pubic hair and poo... | I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me sm... | Inclusion Criteria:
- Men aged 18-35 years
- Ability to understand verbal or written instructions/testing materials in English
- Physically active (as determined by accelerometry and review of a physical activity
log)
- Not taking any prescription medications... | Trial of Testosterone Undecanoate for Optimizing Performance During Military Operations | NCT04120363 | Entailment |
4,378 | 33 | A 20-year-old man comes to the clinic for his routine checkup. The patient wears glasses for myopia and takes no medications. Vital signs are normal. On physical examination, the patient is tall with long upper extremities and fingers. The face appears narrow with down-slanted palpebral fissures, flattened malar bon... | I'm a 20-year-old guy, working as a driver and I went to the clinic for my routine checkup. I have myopia, so I wear glasses and I don't take any other medications. My vitals were normal. I also did a physical exam, and I was told that I have long legs, arms, and fingers. They also told me that my face is quite narrow,... | Inclusion Criteria:
- >18 years old
- Able to read and understand the English language
Exclusion Criteria:
- Significant corneal scarring
- Taking medications that cause miosis (pupil constriction)
- Patients with no light perception
- Pat... | The Oscillation of Crystalline and Intraocular Lenses | NCT04274634 | Entailment |
3,908 | 30 | A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 chi... | I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 year... | Inclusion Criteria:
- have the ability to give informed consent
- be 45 years or over
- have complaints of knee pain for 3-6 months with or without radiographically
established OA (K/L scale score ≥ 1)
- have complaints of knee pain for 3-6 months with or wit... | Molecular Pathways Involved in Knee Pain | NCT04443452 | Entailment |
246 | 2 | A 32-year-old woman comes to the hospital with vaginal spotting. Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with ... | I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing... | Inclusion Criteria:
1. Age 18 through 35 years (inclusive) at screening
2. Non-pregnant women in general good health as determined by the site clinician
3. Premenopausal with history of regular menstrual cycles (regular cycles defined as
occurring every 21-35 days when not ... | Expression of IFN-epsilon in the Female Reproductive Tract | NCT02416154 | Contradiction |
2,020 | 11 | A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that show... | I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and m... | Cases of non-metastatic gastric adenocarcinoma (nmGaC) were defined as patients with
microscopically-confirmed first primary invasive adenocarcinoma of the stomach
(International Classification of Diseases for Oncology, Third Edition (ICD-O-3) code: C16)
without distant metastasis. Only those wh... | Long-term Heart-specific Mortality in the Presence of Competing Risks Among Patients With Non-metastatic Gastric Adenocarcinoma Undergoing Resection and Chemotherapy | NCT04820569 | Entailment |
2,248 | 14 | A 39-year-old man comes to the emergency department with an acute onset of severe left toe pain. The toe is red and exhibits swelling. The patient is not febrile, and does not remember any recent trauma. Medical history is not significant except for the similar attacks and the diagnosis of gouty arthritis. His medicat... | I'm a 39-year-old man and got admitted to the ER after an unbearable pain in my left toe. My toe was red and terribly swollen. I was still standing on my feet, not febrile and I don't remember hitting my head or anything. I don't have any special medical history, but I had been diagnosed with gout before. I take Lopuri... | Inclusion Criteria:
- Self-reported arthritis or chronic joint symptoms
- Currently exercising less than 3 times per week
- Plan to be in community for at least 1 year
- Physician release for participation in physical activity
Exclusion Criteria:
- Pr... | Evaluation of the Active Living Every Day Exercise Program for People With Arthritis | NCT00146367 | Entailment |
37 | 1 | A 19-year-old male came to clinic with some sexual concern. He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates. On physical examination, there is some pubic hair and poo... | I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me sm... | Inclusion Criteria:
- Men with primary or secondary hypogonadism and a serum morning (0900 h ± 30 minutes)
testosterone levels >100 ng/dl and ≤ 300 ng/dL.
- Normal Otolaryngological nasal endoscopy examination.
- Normal prostate examination (no palpable prostatic mass), ... | Efficacy of an Intranasal Testosterone Product | NCT01252745 | Contradiction |
2,099 | 12 | A 47-year-old man comes to the office for routine checkup. He is complaining of chronic cough and occasional but progressive dyspnea. Other medical conditions include hypertension and osteoarthritis. The patient smokes a pack of cigarettes daily and does not use alcohol or illicit drugs. He used to be a construction... | I'm a 47-year-old former construction worker. I'm a man and I smoke a pack of cigs a day but I don't drink or do drugs. I went to my routine checkup because I've been coughing so much lately. I also had shortness of breath and it got worse over time. I already suffer from hypertension and osteoarthritis. My doctor foun... | Inclusion Criteria:
1. Understand and voluntarily sign an informed consent form.
2. >18 and < 75 years old at the time of signing the informed consent form.
3. Able to adhere to the study visit schedule and other protocol requirements.
4. Have a diagnosis of Idiopathic Pulmon... | Pomalidomide for Cough in Patients With Idiopathic Pulmonary Fibrosis | NCT01135199 | Entailment |
5,831 | 44 | A 48-year-old man comes to the office complaining of heartburn and acid reflux. He has taken over-the-counter antacids but sees no relief. Other medical history is unremarkable. The patient does not use tobacco, alcohol, or illicit drugs. Vital signs are within normal limits. BMI is 31 kg/m2. Physical examination... | I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old gu... | Inclusion Criteria:
- 18 years and above
- Attending the medical office and reporting symptoms suggestive of upper
gastrointestinal tract symptoms such as heartburn/regurgitation, abdominal pain,
bloating, belching and nausea/vomiting.
Exclusion Criteria:
... | Prevalence of Gastroesophageal Reflux Disease (GERD) in Patients With Upper Gastrointestinal Tract Symptoms in Egypt | NCT01635959 | Contradiction |
6,911 | 50 | A 70-year-old man comes to the office accompanied by his wife. The patient has experienced progressive memory loss over the last years. He needs help with some of his routine activities, such as paying bills. The patient's wife says, "He used to be such an independent person, but now he needs help with many things, ... | I am a 70-year-old man, and I paid a visit to the doctor with my wife the other day. I noticed that I tend to forget small things and that my memory has decreased over the past few years. I even ask my wife to help me out with my daily routine. I used to be the one paying the bills, but now she has to give me a hand. M... | Inclusion Criteria:
1. Patient and/or study partner (relative) must provide a signed and dated Informed
Consent form prior to any study procedures which will be discussed with the Study
Coordinator.
2. Provision of a letter from the Neurologist/Psychiatrist/Internal Medic... | Study of IGC-AD1 in Subjects With Dementia Due to Alzheimer's Disease | NCT04749563 | Entailment |
894 | 4 | A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes. The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief. Past medical history is notable for hypertension and hypercholesteremia. ... | I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tyl... | Inclusion Criteria:
- Patients with unilateral or bilateral knee OA.
- Subjects of 50 years or above
- palpable bony enlargement
- Crepitus on knee motion
- morning stiffness for less than 30 minutes
- Kellgren and Lawrence scale: Grade 1-3
... | Hip Joint Mobilizations and Strength Training in Patients With Knee OA Osteoarthritis | NCT04769531 | Entailment |
3,076 | 22 | A 15-year-old boy with mild intellectual disability is brought to the office by his parents for a routine physical examination. The boy is going to a school for students with learning disabilities. The patient was adopted, and his immunizations are up to date. Review of the patient's medical records is notable for c... | My husband and I brought our 15-year-old son to the clinic for his routine exam. My son is going to school for special needs students. We adopted him a few years ago. His vaccinations are up to date. He already passed some chromosome testing and they found that he has a fragile X syndrome. The doctor told us that it co... | Inclusion Criteria:1. Confirmed genetic diagnosis of fragile X syndrome
2. Age e 14
3. Verbal IQ e 60 Exclusion Criteria:1. Currently taking any anticholinergic medications,
tricyclic antidepressant medications, or diphenhydramine.
2. Presence of cardiac disease or bradycardia (< 60 b... | An Open-Label Trial of Donepezil in Fragile X Syndrome | NCT00220584 | Entailment |
6,252 | 46 | The patient is a 38-year-old man with cough and body ache that started 3 days ago. He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within n... | I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my tem... | Inclusion Criteria:
1. Adult 18 years-old and older.
2. Person in employment (on fixed-term or permanent contracts) since (at least) March
17th, 2020, the date of national implementation of containment measures in response to
the COVID-19 pandemic.
3. Signed in... | Serological Response to SARS-Cov-2 Virus in Personnel of the Institut Bergonié in the Context of the COVID-19 Pandemic | NCT04426006 | Contradiction |
6,582 | 48 | A 20-year-old man comes to the emergency due to bleeding after a tooth extraction. The bleeding has persisted for approximately 30 minutes despite constant direct pressure. He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family histo... | I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove... | Inclusion criteria :
For participants rolling over into Arm A
- Participants who have completed the studies EFC16923, EFC16925, Arm B or Arm C of the
current study, or any other potential BIVV001 study.
- Male or Female For participants new to BIVV001 (Arm B and C)
... | Long-term Safety and Efficacy of Efanesoctocog Alfa (BIVV001) in Previously Treated Patients With Hemophilia A | NCT04644575 | Contradiction |
2,854 | 21 | A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year. Over the last few months, he has also noticed weakness in the right upper extremity. BP is 120/75, PR is 80 and temperature is 37 C. Reflex... | I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rat... | Inclusion Criteria:
1. Able to comprehend and willing to sign an Informed Consent Form (ICF)
2. Males or females 18 years of age or older
3. A diagnosis of familial or sporadic ALS (defined as meeting the possible,
laboratory-supported probable, probable, or definite criter... | Dose Titration Study to Test Safety and Effects of CK-2017357 in Patients With Amyotrophic Lateral Sclerosis (ALS) | NCT01486849 | Entailment |
2,541 | 18 | A 2-year-old boy is brought to the office by his parents due to a rash that started 1 week ago. A similar red, itchy rash on the cheeks, trunk, and arms has occurred intermittently since infancy. The patient has had a few upper respiratory infections but no major illnesses. Vaccinations are up to date, and he takes ... | I just brought my two-year-old son to the doctor's office because he had a rash for like one week. His rash was on the cheeks, the trunk, and his arms. He already had this before, and it keeps coming back from time to time to time. In the past, he had some respiratory infections but he has never been this sick. His vac... | Inclusion Criteria
1. Pediatric out-patients diagnosed with AD aged 2 to 15 years at the time of written
informed consent. Diagnosis for AD should be made in accordance with the "Guidelines
for Management of Atopic Dermatitis" by the Japanese Dermatological Association.
2... | A Phase 1/2 Study of E6005 in Pediatric Subjects With Atopic Dermatitis | NCT02094235 | Entailment |
6,987 | 50 | A 70-year-old man comes to the office accompanied by his wife. The patient has experienced progressive memory loss over the last years. He needs help with some of his routine activities, such as paying bills. The patient's wife says, "He used to be such an independent person, but now he needs help with many things, ... | I am a 70-year-old man, and I paid a visit to the doctor with my wife the other day. I noticed that I tend to forget small things and that my memory has decreased over the past few years. I even ask my wife to help me out with my daily routine. I used to be the one paying the bills, but now she has to give me a hand. M... | Inclusion Criteria:
- Patients fulfilling the National Institute on Aging and the Alzheimer's Association
diagnostic criteria of probable AD dementia or the NINDS-AIREN (National Institute of
Neurological Disorders and Stroke and Association Internationale pour la Recherché et
... | Good Rate of Clinical Response to Cholinesterase Inhibitors in Alzheimer's Disease After Three Months of Treatment | NCT02007291 | Entailment |
987 | 4 | A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes. The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief. Past medical history is notable for hypertension and hypercholesteremia. ... | I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tyl... | Inclusion Criteria:
- Active complaint of knee pain
- Diagnosis of knee osteoarthritis according to X-ray
- Morning stiffness of less than 30 minutes AND/OR crepitus in active movement
- Ability to read Hebrew
Exclusion Criteria:
- Previous participat... | Integrated Treatment Program for Osteoarthritis of the Knee | NCT02200107 | Entailment |
1,747 | 11 | A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that show... | I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and m... | DISEASE CHARACTERISTICS:
- Diagnosis of cancer with developing febrile neutropenia
- Neutropenia defined as an absolute granulocyte count of less than 1,000/mm^3,
expected to fall to less than 500/mm^3 within 24 hours, secondary to
administration of chemo... | Moxifloxacin Compared With Ciprofloxacin/Amoxicillin in Treating Fever and Neutropenia in Patients With Cancer | NCT00062231 | Contradiction |
202 | 1 | A 19-year-old male came to clinic with some sexual concern. He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates. On physical examination, there is some pubic hair and poo... | I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me sm... | Inclusion Criteria:
- Healthy males between the ages of 18 and 65 years of age exhibiting morning
testosterone ≤350 ng/dL.
- All clinical laboratory tests within normal ranges (any clinically significant
deviation of laboratory results will require approval of sponsor)
... | The Effect on Androxal Versus Androgel on Morning Testosterone in Men With Secondary Hypogonadism (Low Testosterone) | NCT01386606 | Entailment |
5,462 | 40 | A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction. Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration. The patient has heavy menstrual cycles each month. She has no other medical problems and takes no medications... | I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical c... | Inclusion Criteria:
- Women aged 18 to 35 years.
- Women who have freely chosen a low-dose LNG-IUS for the first time as contraceptive
method and it has been successfully inserted previously to invite the woman to
participate in the study.
- Women capable of... | The Aim of This Study is to Estimate the Discontinuation Rate of Low-dose Levonorgestrel-releasing Intrauterine System Due to Self-reported Unacceptable Menstrual Bleeding Pattern in Spanish Women Who Are Using it for the First Time How Intrauterine System for Long Acting Contraception | NCT04785950 | Entailment |
1,242 | 6 | A 61-year-old man comes to the clinic due to nonproductive cough and progressive dyspnea. The patient's medical conditions include hypertension, hypercholesteremia and peptic ulcer disease. He smokes 2 packs of cigarettes daily for the past 30 years. On examination, there are decreased breath sounds and percussive d... | I am 61 and I had to go to the clinic because I couldn't stop coughing and I experienced some breath shortness. I suffer from hypertension and cholesterol and I also have a stomach ulcer. I should admit that I've been smoking 2 packs of cigarettes every day for the past 30 years. My doctor told me that my breath in my ... | Inclusion Criteria:
- male or female subjects 18 years or older
- documented diagnoses of hypertension and of hypercholesterolemia or current therapy
for these conditions
- uncontrolled hypertension (SBP >140 mmHg or DBP >90 mmHg) or cholesterol levels above
... | STITCH2 (Simplified Therapeutic Intervention to Control Hypertension and Hypercholesterolemia) | NCT00637078 | Entailment |
3,568 | 27 | A 31-year-old woman comes to the office due to 3 days of rash on her left arm. The lesion is mildly pruritic but not painful. She is otherwise healthy and occasionally takes ibuprofen during the first few days of her menstrual period. Temperature is 37 C, blood pressure is 110/75 mm Hg, and pulse is 95/min. The lesi... | I went to the clinic because I had a rash on my left arm for three days, and the lesion started to be putrid, but it was not painful. I'm a 31-year-old healthy woman and the only medication I use is ibuprofen when I get my periods. They took my temperature, which turned out to be 37°C and took my blood pressure which w... | Inclusion Criteria:
- erythema migrans in patients > 18 years
Exclusion Criteria:
- pregnancy or lactation
- taking antibiotic with antiborrelial activity within 10 days
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subje... | Cytokines and Chemokines in Erythema Migrans | NCT02147249 | Entailment |
5,968 | 44 | A 48-year-old man comes to the office complaining of heartburn and acid reflux. He has taken over-the-counter antacids but sees no relief. Other medical history is unremarkable. The patient does not use tobacco, alcohol, or illicit drugs. Vital signs are within normal limits. BMI is 31 kg/m2. Physical examination... | I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old gu... | Inclusion Criteria:
- Patient aged from18-50 years who have been diagnosed to have gastric reflux by
gastroenterology departement before the start of treatment, and they also have
sinonasal symptoms.
Exclusion Criteria:
- Pregnant
- Significant nasa... | Gastric Reflux and Sinonasal Symptoms | NCT04105894 | Contradiction |
5,113 | 39 | A 55-year-old white woman comes for a routine checkup. She has no significant medical history and does not use tobacco, alcohol, or illicit drugs. The patient's only medication is an over-the-counter multivitamin. Family history is notable for a hip fracture in her mother. Blood pressure is 130/80 mm Hg and pulse i... | I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse w... | Inclusion Criteria:
- Postmenopausal women (postmenopausal for at least two years)
- Men above 50 years
- Treatment for at least two years with denosumab
- Last denosumab injection less than five months ago
Exclusion Criteria:
- Low-energy vertebral f... | Treatment With Zoledronic Acid Subsequent to Denosumab in Osteoporosis | NCT03087851 | Contradiction |
5,539 | 41 | A 61-year-old man comes to the emergency department complaining of an acute vision disturbance. He had an episode of vision disturbance in the right eye that occurred suddenly and resolved spontaneously in 15 minutes. He also has right jaw pain while chewing. He also complains of fatigue and hip muscle aches over the ... | I’m a 61-year-old man and I came to the ER because I had a sudden episode where I couldn’t see out of my right eye. It only lasted about 15 minutes and went away on its own but it really scared me. I’ve also been having pain in my right jaw when I chew. For the past few months I’ve felt really tired and noticed my hips... | Inclusion Criteria:
- giant celle arteritis with at least 3 ACR criteria including a disgnostic temporal
artery biopsy
- corticosteroid treatment since less than 1 month
- age less than 85 years
- signed informed consent
Exclusion Criteria:
... | Hydroxychloroquine in Giant Cell Arteritis | NCT00430807 | Entailment |
473 | 2 | A 32-year-old woman comes to the hospital with vaginal spotting. Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with ... | I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing... | - INCLUSION CRITERIA:
All pregnant subjects will be recruited under informed consent at Hutzel Hospital. The
study population for both arms of this protocol will involve pregnant women between the
ages of 15 years-old and older at Hutzel Hospital. The ethnic backgrounds are estimated to
... | Early Pregnancy Evaluation by Three-Dimensional Ultrasound | NCT00342290 | Contradiction |
459 | 2 | A 32-year-old woman comes to the hospital with vaginal spotting. Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with ... | I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing... | Inclusion Criteria:
- has regular menstrual cycle (24 to 35 days)
- is at low risk of pregnancy (ie, sterilized, in exclusively same-sex partnership, in
monogamous relationship with vasectomized partner, or using non-hormonal IUD)
- is in good general health as determine... | Study to Evaluate Suppression of Ovulation and Pharmacokinetics of Medroxyprogesterone Acetate Following Administration of TV-46046 in Women With Ovulatory Cycle | NCT02817464 | Contradiction |
6,506 | 47 | A 41-year-old woman comes to the dermatology clinic complaining of facial redness, especially on her forehead and cheeks. She noticed that the redness gets worse in the summer and after sun exposure. She is otherwise healthy. On physical examination, she has multiple papules and pustules present on her forehead, cheeks... | I'm 41, married with 2 lovely kids who are 5 and 9 years old. I have an IUD and I don't want to have more kids. I don't smoke or drink alcohol. I had to go to the dermatology clinic because I had terrible redness on my face, especially on my forehead and cheeks. It got worse in the summer and after being under the sun.... | Inclusion Criteria:
1. Male or female subjects ≥18 years of age at the time of consent.
2. Subjects do not have any medical conditions, other than rosacea, that in the opinion
of the investigator, put the subject at unacceptable risk or could interfere with
study assessme... | Topical Minocycline Gel for Inflammatory Lesions of Papulopustular Rosacea | NCT03667222 | Entailment |
5,897 | 44 | A 48-year-old man comes to the office complaining of heartburn and acid reflux. He has taken over-the-counter antacids but sees no relief. Other medical history is unremarkable. The patient does not use tobacco, alcohol, or illicit drugs. Vital signs are within normal limits. BMI is 31 kg/m2. Physical examination... | I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old gu... | Inclusion Criteria:
- Adults between 19 and 75 years old based on the date of written agreement
- Those who have been diagnosed with erosive gastroesophageal reflux disease(EGRD) of LA
Grade A-D on the upper gastrointestinal endoscopy
- Those who experienced symptoms of ... | Clinical Trial to Evaluate the Safety and Efficacy of JP-1366 in Patients With Erosive Gastroesophageal Reflux Disease | NCT04282954 | Contradiction |
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