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values | premise stringlengths 111 17k | NCT_title stringlengths 18 299 | NCT_id stringlengths 11 11 | label stringclasses 2
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4,376 | 33 | A 20-year-old man comes to the clinic for his routine checkup. The patient wears glasses for myopia and takes no medications. Vital signs are normal. On physical examination, the patient is tall with long upper extremities and fingers. The face appears narrow with down-slanted palpebral fissures, flattened malar bon... | I'm a 20-year-old guy, working as a driver and I went to the clinic for my routine checkup. I have myopia, so I wear glasses and I don't take any other medications. My vitals were normal. I also did a physical exam, and I was told that I have long legs, arms, and fingers. They also told me that my face is quite narrow,... | Inclusion criteria : adult ;
Exclusion criteria : temporomandibular disorders (TMD symptom questionnaire)
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
| Condylar Inclination Recorded With Modjaw® Device. | NCT04694040 | Entailment |
3,119 | 23 | A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn. The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness. She also reports occasional joint pain. Medical history... | I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to t... | Inclusion Criteria:
1. Provide written informed consent
2. Male or female subjects aged 18 to 80 years, inclusive
3. Have a history of dry eye disease (DED) in both eyes
4. Be on stable regimens of other needed medications
5. Have a BCVA of +0.7 or better as assess... | Evaluation of P-321 Ophthalmic Solution Compared to Placebo in Subjects With Dry Eye Disease | NCT02831387 | Contradiction |
645 | 3 | A 51-year-old man comes to the office complaining of fatigue and some sexual problems including lack of libido. The patient doesn't smoke or use any illicit drug. Blood pressure is 120/80 mm Hg and pulse is 70/min. Oxygen saturation is 99% on room air. BMI is 24 kg/m2. Skin examination shows increased pigmentation.... | I am 51 years old and I just came back from the doctor's office. I'm sick and tired of being that exhausted, reaching the point where me and my lovely wife are not touching each other anymore! I'm not smoking or doing drugs! My blood pressure was 120/80 mm Hg, and pulse was 70/min and my oxygen saturation 99%. My BMI i... | Inclusion Criteria for patients:
- Man or woman older than 18 years
- Subject having a liver iron overload greater than or equal to 100 umol /g dry liver
weight, confirmed by MRI (done performed with body antenna and complete deactivation
of the surface antenna) and / o... | Analysis of the Modulation of Serum Hepcidin Level in Response to Iron Oral Intake: Potential Interest for the Differential Diagnosis Between Ferroportin Disease and Dysmetabolic Hepatosiderosis. | NCT01949467 | Contradiction |
3,569 | 27 | A 31-year-old woman comes to the office due to 3 days of rash on her left arm. The lesion is mildly pruritic but not painful. She is otherwise healthy and occasionally takes ibuprofen during the first few days of her menstrual period. Temperature is 37 C, blood pressure is 110/75 mm Hg, and pulse is 95/min. The lesi... | I went to the clinic because I had a rash on my left arm for three days, and the lesion started to be putrid, but it was not painful. I'm a 31-year-old healthy woman and the only medication I use is ibuprofen when I get my periods. They took my temperature, which turned out to be 37°C and took my blood pressure which w... | - INCLUSION CRITERIA:
- Clinical diagnosis of suspected, confirmed, or probable LB or other TBD per CDC case
definitions.
- Has not received antibiotic therapy for tick-borne disease for more than 2 weeks.
- Age >=18 years.
- Able to provide informed consent... | Evaluation and Follow-up of People With Tick-borne Diseases | NCT04318925 | Entailment |
6,895 | 50 | A 70-year-old man comes to the office accompanied by his wife. The patient has experienced progressive memory loss over the last years. He needs help with some of his routine activities, such as paying bills. The patient's wife says, "He used to be such an independent person, but now he needs help with many things, ... | I am a 70-year-old man, and I paid a visit to the doctor with my wife the other day. I noticed that I tend to forget small things and that my memory has decreased over the past few years. I even ask my wife to help me out with my daily routine. I used to be the one paying the bills, but now she has to give me a hand. M... | Inclusion Criteria:
- Existence of a probable Alzheimer's disease (AD) according to the NIAA criteria
(McKhann et al., 2011) with a Mini Mental State Examination (MMSE) greater than or
equal to 20 (threshold defined in order not to include certain participants whose
co... | ARIADE : Augmented Reality for Improving Autonomy in Dementia | NCT04742465 | Entailment |
3,027 | 22 | A 15-year-old boy with mild intellectual disability is brought to the office by his parents for a routine physical examination. The boy is going to a school for students with learning disabilities. The patient was adopted, and his immunizations are up to date. Review of the patient's medical records is notable for c... | My husband and I brought our 15-year-old son to the clinic for his routine exam. My son is going to school for special needs students. We adopted him a few years ago. His vaccinations are up to date. He already passed some chromosome testing and they found that he has a fragile X syndrome. The doctor told us that it co... | Inclusion Criteria:
1. Successfully completed all scheduled visits of the previous protocol ( 22002,
209FX301, or 209FX302).
2. A parent,LAR, or caregiver must be willing and able to accompany the subject to all
study visits, participate in phone calls, complete study ass... | An Open Label Extension Study in Subjects With Fragile X Syndrome | NCT01555333 | Entailment |
1,421 | 9 | A 67-year-old woman comes to the clinic due to recent episode of choking, dysphagia, and cough. Her other medical problems include hypertension, dyslipidemia, and osteoarthritis. She does not smoke or use alcohol. She lives with her husband and she is able to do her own daily activities. She used to teach elementary ... | I'm a 67-year-old lady, and I went to the clinic due to nonstop choking, difficulty swallowing, and coughing. I also suffer from hypertension, cholesterol, and osteoarthritis. I do not smoke or drink alcohol. I live with my husband, and we are independent retired elementary school teachers. During the exam, my blood pr... | Inclusion Criteria:
- Male or Female adults, 18 years or over
- Essential Hypertension with mean SBP (systolic blood pressure) ≥ 140 mm Hg or mean DBP
(diastolic blood pressure) ≥ 90 mm Hg* when blood pressure is measured at Visit 1(week
-2) and at Visit 2(week 0).
... | LAAS (Losartan Anti-Atherosclerosis Study)(0954-330)(COMPLETED) | NCT00496834 | Contradiction |
3,008 | 22 | A 15-year-old boy with mild intellectual disability is brought to the office by his parents for a routine physical examination. The boy is going to a school for students with learning disabilities. The patient was adopted, and his immunizations are up to date. Review of the patient's medical records is notable for c... | My husband and I brought our 15-year-old son to the clinic for his routine exam. My son is going to school for special needs students. We adopted him a few years ago. His vaccinations are up to date. He already passed some chromosome testing and they found that he has a fragile X syndrome. The doctor told us that it co... | Inclusion Criteria:
- Fragile X Syndrome
Exclusion Criteria:
- Current or past SSRI treatment
- Current or past MAOI (monoamine oxidase inhibitor ) treatment
- Serious co-morbid medical disorder affecting brain function and behavior (not
including fr... | Trial of Sertraline to Treat Children With Fragile X Syndrome | NCT01474746 | Contradiction |
61 | 1 | A 19-year-old male came to clinic with some sexual concern. He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates. On physical examination, there is some pubic hair and poo... | I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me sm... | Inclusion Criteria:
1. ED complaint ongoing for over 3 months;
2. Age comprise between 45 and 80 years old;
3. Had a stable heterosexual relationship for more than 3 months and anticipates having
the same partner for all the study
4. Has not responded adequately ... | Co-Administering Testosterone With PDE5 Inhibitors in ED Patients Non Responders to PDE5 Inhibitors Alone | NCT00244023 | Contradiction |
904 | 4 | A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes. The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief. Past medical history is notable for hypertension and hypercholesteremia. ... | I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tyl... | Inclusion Criteria:
- Subjects who are capable of giving written informed consent, which includes compliance
with the requirements and restrictions listed in the consent form.
- Ambulatory non pregnant females and males 40-<80 years of age.
- Subjects who withdraw pain m... | Efficacy Study of "Go On" in Magnetic Resonance Imaging (MRI) Improvement in Osteoarthritis (OA) Knee | NCT00750724 | Entailment |
3,196 | 23 | A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn. The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness. She also reports occasional joint pain. Medical history... | I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to t... | Inclusion Criteria:
- Dry eye patients with Sjögren's syndrome
- Corneal and conjunctival damage
Exclusion Criteria:
- Severe ophthalmic disorder
- Punctal plugs or surgery for occlusion of the lacrimal puncta
No condition on gender to be admitted to the trial.
... | A Long-term Study of KCT-0809 in Dry Eye Patients With Sjögren's Syndrome | NCT02503163 | Entailment |
555 | 2 | A 32-year-old woman comes to the hospital with vaginal spotting. Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with ... | I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing... | Inclusion Criteria:
- Females aged 18 to 42 years with regular menstrual cycles of 26-34 days
- Undergoing ovarian stimulation for IVF/ICSI & PGS.
- Receiving recombinant FSH for stimulation
- hCG 5000iu IM as trigger injection for oocyte maturation.
- Ovarian... | A Proof of Concept Study of Serum Progesterone Levels for IVF/ICSI Following HCG Trigger for Oocyte Maturation | NCT04417569 | Contradiction |
4,692 | 35 | A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles. The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days. She is sexually active with her husband and... | I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of ... | Inclusion Criteria:
1. Age 18 through 45 years (inclusive) at screening
2. Able and willing to provide written informed consent to be screened for and enrolled
in the study
3. Able and willing to provide adequate locator information at screening
4. HIV-uninfected... | Vaginal Antibody Safety Trial: Safety Study of Monoclonal Antibodies to Reduce the Vaginal Transmission of Herpes Simplex Virus (HSV) and Human Immunodeficiency Virus (HIV) | NCT02579083 | Entailment |
6,100 | 46 | The patient is a 38-year-old man with cough and body ache that started 3 days ago. He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within n... | I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my tem... | Inclusion Criteria:
- All consecutive patients with mild to moderate COVID-19 infection
- Age >18 years,
- Clinical diagnosis of COVID19 infection
- Patients should present fever, cough and myalgia and weakness and radiological
findings of pneumonia.
... | Baricitinib in Symptomatic Patients Infected by COVID-19: an Open-label, Pilot Study. | NCT04320277 | Contradiction |
6,166 | 46 | The patient is a 38-year-old man with cough and body ache that started 3 days ago. He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within n... | I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my tem... | Inclusion Criteria:
- Residents of participating nursing home - who benefited from a rapid diagnostic
orientation serological test for COVID-19 - having given their agreement
- All staff members (doctors, nurses, health executives, caregivers, physiotherapists,
ASH, str... | COVID-19 Prevalence in UNIVI Geriatric Institutions: Epidemiological Study of Immunological Status With Rapid Serological Tests | NCT04790994 | Contradiction |
2,072 | 12 | A 47-year-old man comes to the office for routine checkup. He is complaining of chronic cough and occasional but progressive dyspnea. Other medical conditions include hypertension and osteoarthritis. The patient smokes a pack of cigarettes daily and does not use alcohol or illicit drugs. He used to be a construction... | I'm a 47-year-old former construction worker. I'm a man and I smoke a pack of cigs a day but I don't drink or do drugs. I went to my routine checkup because I've been coughing so much lately. I also had shortness of breath and it got worse over time. I already suffer from hypertension and osteoarthritis. My doctor foun... | Inclusion Criteria:
- 45 and 79 years of age.
- Clinical symptoms of IPF for at least 3 months.
- Forced vital capacity (FVC) between 50 to 90% of the predicted value.
- DLco at least 35% of the predicted value.
- PaO2 > 55 mm Hg while breathing ambient air at... | Azathioprine and Prednisone in the Treatment of Idiopathic Pulmonary Fibrosis | NCT00518310 | Entailment |
2,585 | 20 | A 49-year-old man comes to the office because of the bulging in his groin. Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases. His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications... | I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to... | - Inclusion criteria:
1. Patients who underwent elective inguinal hernia repair (will consider the hernia
size).
2. Age from 18-70. (70 with no other comorbiditeis)
3. Their ASA score 1,2 or 3 (American Society of Anesthesia)
4. General ... | Effect of Ultra-Sound Guided Pre-emptive Nerve Block on Post-operative Pain Following Open Inguinal Hernia Repair. | NCT04792164 | Contradiction |
956 | 4 | A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes. The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief. Past medical history is notable for hypertension and hypercholesteremia. ... | I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tyl... | Inclusion Criteria:
- Patients who have symptomatic basal joint arthritis.
- Patients who are capable of providing informed consent
Exclusion Criteria:
- Patients younger than 18 years old at the time of enrollment
- Patients with neuromuscular disease affecting ... | Basal Joint Arthritis Prospective | NCT01376024 | Entailment |
3,791 | 30 | A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 chi... | I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 year... | Inclusion criteria:
- Subjects diagnosed with primary Osteoarthritis of the knee.
- Have at least 3 months in symptom duration prior to screening visit.
- Regular user of a prescribed non-steroidal anti-inflammatory drug (NSAID) or selective
cyclo-oxygenase II (COX2) inh... | Effectiveness Of Single Doses Of Ibuprofen In Patients With Osteoarthritis Of The Knee | NCT00372801 | Entailment |
2,748 | 20 | A 49-year-old man comes to the office because of the bulging in his groin. Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases. His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications... | I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to... | Inclusion Criteria:
- Subjects scheduled for laparoscopic unilateral inguinal hernia repair
- ASA 1 or2.
- Age >18 years.
Exclusion Criteria:
- Pregnancy or lactating
- Allergy to NAC
- History of chronic pain
- Use of opioids ... | Pilot Study: Postoperative Pain Reduction by Pre Emptive N-Acetylcysteine | NCT03354572 | Entailment |
142 | 1 | A 19-year-old male came to clinic with some sexual concern. He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates. On physical examination, there is some pubic hair and poo... | I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me sm... | - ELIGIBILITY CRITERIA FOR IGD PATIENTS:
INCLUSION CRITERIA:
Males or females with clinical findings consistent with IGD who are greater than or equal
to 18 years old and treated with hormone replacement therapy for IGD at the full adult
replacement dose for at least 3 months. Clinica... | Psychological Outcomes in Isolated GnRH Deficiency | NCT02356172 | Contradiction |
2,047 | 12 | A 47-year-old man comes to the office for routine checkup. He is complaining of chronic cough and occasional but progressive dyspnea. Other medical conditions include hypertension and osteoarthritis. The patient smokes a pack of cigarettes daily and does not use alcohol or illicit drugs. He used to be a construction... | I'm a 47-year-old former construction worker. I'm a man and I smoke a pack of cigs a day but I don't drink or do drugs. I went to my routine checkup because I've been coughing so much lately. I also had shortness of breath and it got worse over time. I already suffer from hypertension and osteoarthritis. My doctor foun... | Inclusion Criteria:
- The only subjects to be included in this study are those diagnosed with Idiopathic
Pulmonary Fibrosis with diagnosis based on the criteria published by the American
Thoracic Society in the International Consensus Statement.
1. Exclusion of othe... | Clinical Trial of Low Dose Oral Interferon Alpha in Idiopathic Pulmonary Fibrosis | NCT01442779 | Contradiction |
6,487 | 47 | A 41-year-old woman comes to the dermatology clinic complaining of facial redness, especially on her forehead and cheeks. She noticed that the redness gets worse in the summer and after sun exposure. She is otherwise healthy. On physical examination, she has multiple papules and pustules present on her forehead, cheeks... | I'm 41, married with 2 lovely kids who are 5 and 9 years old. I have an IUD and I don't want to have more kids. I don't smoke or drink alcohol. I had to go to the dermatology clinic because I had terrible redness on my face, especially on my forehead and cheeks. It got worse in the summer and after being under the sun.... | Inclusion Criteria:
- A diagnosis of papulopustular rosacea
- Grade 3 or 4 on the 5-point Investigator Global Assessment scale
- Presence of telangiectasia
Exclusion Criteria:
- steroid rosacea or subtype 3 (phymatous rosacea)
- clinically significant... | A 21 Day Pharmacokinetics Study in Papulopustular Rosacea | NCT02028286 | Entailment |
6,124 | 46 | The patient is a 38-year-old man with cough and body ache that started 3 days ago. He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within n... | I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my tem... | Inclusion Criteria:
- Clinical, radiological and PCR positive COVID-19 diagnosis
Exclusion Criteria:
- less than 18 years old
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at mos... | Prognostic Factors in Patients Admitted to an Urban Teaching Hospital With COVID-19 Infection | NCT04484545 | Contradiction |
1,832 | 11 | A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that show... | I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and m... | Inclusion Criteria:
- In principle, all patients treated for gastrointestinal tumors will be included (only
with the permission (informed consent) of the patient)
Exclusion Criteria:
- In case of a known contraindication for MRI (eg pacemaker), the patient will not be
... | Whole Body Diffusion MRI for Non-invasive Lesion Detection and Therapy Follow-up: Study With Patients With Gastro-intestinal Tumors | NCT01224990 | Entailment |
6,026 | 44 | A 48-year-old man comes to the office complaining of heartburn and acid reflux. He has taken over-the-counter antacids but sees no relief. Other medical history is unremarkable. The patient does not use tobacco, alcohol, or illicit drugs. Vital signs are within normal limits. BMI is 31 kg/m2. Physical examination... | I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old gu... | Inclusion Criteria:
1. Heartburn on at least 2 days of the past 7 days prior to screening, with or without a
history of EE or a documented diagnosis of GERD within 6 months prior to screening,
with or without a history of EE.
2. Body mass index (BMI) of ≥18.5 and ≤35 kg/m... | An Open, Randomized, Two Way Crossover Study Comparing the Effect of 20mg Esomeprazole Administered Orally and Intravenously as a 15 Minute Infusion on Basal and Pentagastrin-Stimulated Acid Output in Subjects With Symptoms of Gastroesophageal Reflux Disease (GERD) | NCT00629564 | Entailment |
588 | 2 | A 32-year-old woman comes to the hospital with vaginal spotting. Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with ... | I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing... | Inclusion Criteria:
- Women undergoing a frozen thawed embryo transfer cycle with poor endometrial response
to estrogen (< 7 mm) after at least two standard preparation protocols, of which one
was canceled due to thin endometrium
Exclusion Criteria:
- none
Fema... | Platelet-Rich Protein and the Endometrium | NCT02973555 | Entailment |
3,259 | 23 | A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn. The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness. She also reports occasional joint pain. Medical history... | I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to t... | Inclusion Criteria:
- Male or female patient ≥ 18 years
- Primary sjögren syndrome according of age to 2002 or 2016 classification criteria
Exclusion Criteria:
- Secondary sjögren syndrome
No condition on gender to be admitted to the trial.
No healthy subjects accepted to jo... | Ultrasound Abnormalities of the Salivary Glands in Primary Sjögren's Syndrome According to the Duration of the Disease | NCT04212572 | Entailment |
4,833 | 37 | A 47-year-old man comes to the office due to weight gain and fatigue. He is not able to lift heavy objects or climb stairs. Family history is positive for DM type 2 and HTN in his father. Blood pressure is 165/90 mm Hg and pulse is 85/min. On physical examination, there is symmetric proximal muscle weakness of the u... | I'm a 47-year-old man. I went to the clinic because I had been gaining weight and had increased fatigue over the past few weeks. I was not able to lift heavy objects or even climb the stairs. My dad was diagnosed with type 2 diabetes and high blood pressure. During the exam, they took my blood pressure, which was 165/9... | Inclusion Criteria:
Individuals eligible for enrollment into this study are adult male and non-pregnant female
adult patients who:
- Are at least 18 years of age
- Have a confirmed diagnosis of endogenous hypercortisolemia caused by ACTH dependent or
ACTH independen... | A Study of the Efficacy and Safety of CORLUX in the Treatment of Endogenous Cushing's Syndrome | NCT00569582 | Contradiction |
6,280 | 46 | The patient is a 38-year-old man with cough and body ache that started 3 days ago. He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within n... | I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my tem... | Inclusion Criteria:
- Patients over 18 years of age
- Of both sexes
- Confirmed case of Covid-19 (by RT-PCR) and CT less than 32 in the E
- That they go to the ER service due to COVID symptoms, and that they voluntarily agree
to participate in the study by wr... | Outpatient Treatment With CoVid-19 With Prexablu | NCT04619290 | Entailment |
6,398 | 46 | The patient is a 38-year-old man with cough and body ache that started 3 days ago. He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within n... | I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my tem... | Inclusion Criteria:
- Patient (of all ages) with symptoms compatible with infection by Covid-19 treated at the
GHPSJ or in one of the establishments in the Paris Plaisance hospital city.
Exclusion Criteria:
- Asymptomatic patient
- Patient objecting to the use of their ... | Become of Patients Infected or Suspected of Being Infected by Covid-19 and Supported by the GHPSJ and the Establishments of the Paris Plaisance Hospital City | NCT04365530 | Entailment |
4,317 | 32 | A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia. The patient is sexually active with his wife and does not use any contraception methods. They have been trying to conceive for the past year with no success. The patient has a past medical history of recurrent p... | I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet ... | Inclusion Criteria:
- Male or female with confirmed diagnosis of CF based on consensus criteria
- Aged 19 years or older
- Stable clinical status
- Pre-bronchodilator FEV1.0 between 30% and 90% predicted
- Body mass index between 16 and 30 kg/m2
- ... | CF Bronchodilation | NCT03522831 | Entailment |
993 | 4 | A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes. The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief. Past medical history is notable for hypertension and hypercholesteremia. ... | I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tyl... | Inclusion Criteria:
- Eligible patients are those aged 40 years or older who are diagnosed with KOA and have
signed the informed consent.
- The diagnosis of KOA will follow the diagnostic criteria according to the Chinese
Guidelines for the Medical Management of Osteoar... | A Pilot Trial of Acupuncture for Knee Osteoarthritis With Differential Functional Status of Acupoints | NCT03008668 | Entailment |
2,268 | 15 | An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity m... | I brought my 8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weak... | Inclusion Criteria:
- Written consent/assent by patient and/or legal guardian as per regional and/or
Institutional Review Board (IRB)/Independent Ethics Committee (IEC) requirements
- Diagnosis of DMD based on a clinical phenotype with increased serum creatine kinase
(C... | Phase III Study of Edasalonexent in Boys With Duchenne Muscular Dystrophy | NCT03703882 | Contradiction |
5,503 | 41 | A 61-year-old man comes to the emergency department complaining of an acute vision disturbance. He had an episode of vision disturbance in the right eye that occurred suddenly and resolved spontaneously in 15 minutes. He also has right jaw pain while chewing. He also complains of fatigue and hip muscle aches over the ... | I’m a 61-year-old man and I came to the ER because I had a sudden episode where I couldn’t see out of my right eye. It only lasted about 15 minutes and went away on its own but it really scared me. I’ve also been having pain in my right jaw when I chew. For the past few months I’ve felt really tired and noticed my hips... | Inclusion criteria :
- Diagnosis of giant cell arteritis (GCA) according to European League Against
Rheumatism/American College of Rheumatology classification criteria.
- New onset active disease or refractory active disease.
- At least one of the symptoms of GCA within ... | Evaluation of Efficacy and Safety of Sarilumab in Patients With GCA | NCT03600805 | Entailment |
1,886 | 11 | A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that show... | I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and m... | - INCLUSION CRITERIA:
Two groups of symptomatic patients aged 40 to 70 years old, who are long term residents of
a high gastric cancer risk area:
- Approximately 1300 patients who need upper endoscopy (examination of the lining of the
stomach with a flexible tube).
... | Gastric Cancer Precursor Lesions (GCPL) Study | NCT03188406 | Entailment |
4,843 | 37 | A 47-year-old man comes to the office due to weight gain and fatigue. He is not able to lift heavy objects or climb stairs. Family history is positive for DM type 2 and HTN in his father. Blood pressure is 165/90 mm Hg and pulse is 85/min. On physical examination, there is symmetric proximal muscle weakness of the u... | I'm a 47-year-old man. I went to the clinic because I had been gaining weight and had increased fatigue over the past few weeks. I was not able to lift heavy objects or even climb the stairs. My dad was diagnosed with type 2 diabetes and high blood pressure. During the exam, they took my blood pressure, which was 165/9... | Inclusion Criteria:
- Are at least 18 years of age.
- Have a presumptive diagnosis of Cushing's disease (Cushing's syndrome due to an ACTH
secreting pituitary tumor).
- Have previously had pituitary surgery and/or pituitary radiation with the intent of
curin... | A Study to Confirm Recurrent or Persistent Cushing's Syndrome in Patients With Signs or Symptoms of Hypercortisolemia | NCT00796783 | Contradiction |
6,842 | 49 | A 50-year-old woman comes to the clinic complaining of difficulty swallowing both liquids and solid foods, as well as occasional cough while eating. She also has difficulty lifting her arms above her head and getting up from a chair. The weakness seems to get worse gradually. The patient has no prior medical problems ... | I had to go to the clinic because of difficulty swallowing all kinds of food, liquid and solid. I also sometimes cough when I eat my dinner. At only 50 year old, I had some difficulties lifting up my arms and getting up from a chair! And it's only getting worse! I never had any medical issues in the past and I'm not un... | Inclusion Criteria:
- History of dysphagia necessitating a dynamic fluoroscopic swallow study
- Age > 18 years
- Ability to complete a comprehensive dynamic fluoroscopic swallow study
- Ability to provide informed consent for study participation
Exclusion Criteri... | Evaluation of Two Different Thickening Products in Patients With Dysphagia | NCT01651975 | Entailment |
2,481 | 17 | A 67-year-old man comes to the clinic with slowly worsening vision in both eyes. He is not able to drive at night, as the symptoms are worse at night. His pupils are normal in diameter both in the light and darkness. Other medical history is unremarkable. Ocular examination shows loss of the red reflex and blurry vis... | I am a 67 years-old man, and I haven't been able to drive at night due to my vision getting worse. My vision is not the best in general, but night makes it even worse. The ophthalmologist told me that my pupils were normal. However, I have slow reflexes and blurry vision. My acuity test came back with 50/100 vision in ... | Inclusion Criteria:
- No significant supplementary carotenoids within last 10 weeks. Without significant
media opacity, cataract or congenital / acquired retinal disease other than atrophic
AMD or diabetic retinopathy. Minimum 20/25 to enroll.
Exclusion Criteria:
... | "Night Vision and Carotenoids" | NCT04741763 | Entailment |
6,641 | 48 | A 20-year-old man comes to the emergency due to bleeding after a tooth extraction. The bleeding has persisted for approximately 30 minutes despite constant direct pressure. He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family histo... | I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove... | Inclusion Criteria:
- Severe Haemophilia A (FVIII:C < 1%)
- Male patients >= 18 years of age
- Previous treatment with a FVIII concentrate for at least 150 EDs
- Good documentation regarding dosing and bleeding frequency in the 6 months preceding
study start
... | Assess the Efficacy and Safety of Personalized Prophylaxis Human-cl rhFVIII in Patients With Severe Haemophilia A | NCT02256917 | Contradiction |
606 | 2 | A 32-year-old woman comes to the hospital with vaginal spotting. Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with ... | I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing... | Inclusion Criteria:
- Primary or secondary infertility due to:
- Ovulatory dysfunction
- Mild male infertility
- Unexplained infertility
- Endometrium < 6 mm at time of hCG during previous treatment with clomiphene citrate
- Age 18-35
Excl... | Tamoxifen Compared With Clomiphene Citrate for Women Who Had Thin Endometrium Women Under Clomiphene in a Previous Cycle | NCT00449514 | Entailment |
2,433 | 16 | A 39-year-old woman comes to the clinic complaining of arthralgias and nodules on her legs. She has no fever or other skin rashes. The prior medical condition is unremarkable, and she takes no medications. On physical examination, there is moderate hepatomegaly. The lesions on her legs are tender and present predomin... | I'm just a 39-year-old young woman but lately I have noticed some underlying cysts on my legs and my joints were hurting so much. I don't have a fever. I don't have rashes. My medical history is totally clean and I don't take any medication. When I went to the clinic they did a physical examination where they found tha... | Inclusion Criteria: Patients meeting all the following criteria will be eligible for
inclusion in the study:
- Age group of 18 to 75 years
- Clinicoradiological suspicion of sarcoidosis where EBUS-TBNA is being planned
- Enlarged hilar and mediastinal lymph nodes >10 mm (any ... | A Study Evaluating the Diagnostic Yield and Safety of the ProCore vs Conventional EBUS-TBNA Needle in Subjects With Suspected Sarcoidosis | NCT03656003 | Contradiction |
2,708 | 20 | A 49-year-old man comes to the office because of the bulging in his groin. Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases. His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications... | I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to... | Inclusion Criteria:
- unilateral groin hernia
- planned laparoscopic inguinal or femoral herniorrhaphy
- ASA I-III
- fluent Danish
Exclusion Criteria:
- converting to open operation
- low compliance
- daily use of morphine or s... | Fibrin Glue Versus Tacked Fixation in Groin Hernia Repair (TAPP) | NCT01000116 | Entailment |
1,661 | 10 | A 19-year-old girl comes to the clinic due to a left wrist mass. She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns. Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient n... | I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penli... | Inclusion Criteria:
INCLUSION CRITERIA:
- Subjects will be over 18 years of age.
- Healthy life-time non-smokers
Exclusion Criteria:
- Presence of airflow obstruction (COPD, asthma, bronchiectasis)
- Other concomitant inflammatory pulmonary disorders
... | Evaluation of Acute and Subacute Effects of Nicotine Free Electronic Cigarette(NCFE) Vapors | NCT02585791 | Entailment |
3,903 | 30 | A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 chi... | I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 year... | Inclusion Criteria:
- with clinical and radiological hip or knee OA confirmed by a physician,
- whatever their status regarding flare of OA. The intention of the Flare-OA tool is not
to detect current flare only, but also a flare that may have occurred before the
encoun... | Self-assessment of Flare in Osteoarthritis of Lower Limbs | NCT02892058 | Entailment |
1,590 | 10 | A 19-year-old girl comes to the clinic due to a left wrist mass. She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns. Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient n... | I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penli... | Inclusion Criteria:
- Patients who have a pre-existing intra-arterial blood pressure (A-Line) line for
standard care
- Patients that are ≥18 years of age.
Exclusion Criteria:
- Body habitus that precludes patients from wearing a device on their wrist
... | Wrist Worn Blood Pressure Measurement | NCT03919136 | Contradiction |
1,515 | 9 | A 67-year-old woman comes to the clinic due to recent episode of choking, dysphagia, and cough. Her other medical problems include hypertension, dyslipidemia, and osteoarthritis. She does not smoke or use alcohol. She lives with her husband and she is able to do her own daily activities. She used to teach elementary ... | I'm a 67-year-old lady, and I went to the clinic due to nonstop choking, difficulty swallowing, and coughing. I also suffer from hypertension, cholesterol, and osteoarthritis. I do not smoke or drink alcohol. I live with my husband, and we are independent retired elementary school teachers. During the exam, my blood pr... | Inclusion Criteria:
- Men/Women, 40 or older, diagnosed with hip or knee Osteoarthritis.
- Hypertensive patient with treated and controlled essential hypertension.
- Must receive at least one antihypertensive treatment from the following drug classes:
Diuretic, Angiotens... | A Study to Assess the Effects of Naproxcinod and Naproxen on Blood Pressure Measurements in Osteoarthritis Patients With Controlled High Blood Pressure | NCT00662610 | Entailment |
1,008 | 4 | A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes. The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief. Past medical history is notable for hypertension and hypercholesteremia. ... | I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tyl... | Inclusion Criteria:
- Self-reported joint pain with a minimum pain rating of 3/10 for at least the past 30
days
- Recreationally active (2 or more days per week)
- Not obese (BMI < 30kg/m2)
Exclusion Criteria:
- Tobacco users/Smokers
- Al... | Yeahhh Baby! Ointment on Hip and/or Knee Pain in Men and Women | NCT04764552 | Entailment |
2,149 | 14 | A 39-year-old man comes to the emergency department with an acute onset of severe left toe pain. The toe is red and exhibits swelling. The patient is not febrile, and does not remember any recent trauma. Medical history is not significant except for the similar attacks and the diagnosis of gouty arthritis. His medicat... | I'm a 39-year-old man and got admitted to the ER after an unbearable pain in my left toe. My toe was red and terribly swollen. I was still standing on my feet, not febrile and I don't remember hitting my head or anything. I don't have any special medical history, but I had been diagnosed with gout before. I take Lopuri... | Inclusion Criteria:
Age 18-65 years old those who are willing to accept assessment and sign informed consent.
Under the normal purine diet, two fasting blood uric acid levels on different days:
420umol/l <blood uric acid <540 umol/l (male), 360 umol/l <blood uric acid <540 umol/l
(fema... | Effects of Barley Green in Patients With Hyperuricemia | NCT04438486 | Contradiction |
4,628 | 35 | A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles. The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days. She is sexually active with her husband and... | I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of ... | Inclusion Criteria:
- Assigned female sex at birth
- Note: Participants who are female at birth, who now identify as male, will not be
excluded so long as they are not on female-to-male transition therapy.
- Age 18 through 45 years (inclusive) at Screening, ver... | Pharmacokinetic and Safety Study of a 90 Day Intravaginal Ring Containing Tenofovir | NCT03670355 | Entailment |
5,685 | 42 | A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively. On physical examination, the patient's height is in the 5th percentile of her age. Other findings include low-set ears, a high arched palate... | I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a we... | Inclusion Criteria:
- Children with overweight and not obese according to the definitions developed by Cole et
al (4). It implies that we include children with the following age specific BMI Inclusion
criteria
- 9 years = AGE < 9 years, 6 months AND 19,0< BMI<23,0
- 9 ye... | Treatment of Overweight in Children on Distance | NCT02720302 | Entailment |
4,840 | 37 | A 47-year-old man comes to the office due to weight gain and fatigue. He is not able to lift heavy objects or climb stairs. Family history is positive for DM type 2 and HTN in his father. Blood pressure is 165/90 mm Hg and pulse is 85/min. On physical examination, there is symmetric proximal muscle weakness of the u... | I'm a 47-year-old man. I went to the clinic because I had been gaining weight and had increased fatigue over the past few weeks. I was not able to lift heavy objects or even climb the stairs. My dad was diagnosed with type 2 diabetes and high blood pressure. During the exam, they took my blood pressure, which was 165/9... | - INCLUSION CRITERIA:
Subjects will be included if they have ALL of the three following criteria:
1. Hypercortisolism from Cushing's syndrome caused by ACTH ectopic secretion
AND
2. Glycemic disorder that is considered to be caused or worsened by the hypercortisolism
... | Prospective, Open-Label, Multicenter, International Study of Mifepristone for Symptomatic Treatment of Cushing's Syndrome Caused by Ectopic Adrenal Corticotrophin Hormone (ACTH) Secretion | NCT00422201 | Contradiction |
2,211 | 14 | A 39-year-old man comes to the emergency department with an acute onset of severe left toe pain. The toe is red and exhibits swelling. The patient is not febrile, and does not remember any recent trauma. Medical history is not significant except for the similar attacks and the diagnosis of gouty arthritis. His medicat... | I'm a 39-year-old man and got admitted to the ER after an unbearable pain in my left toe. My toe was red and terribly swollen. I was still standing on my feet, not febrile and I don't remember hitting my head or anything. I don't have any special medical history, but I had been diagnosed with gout before. I take Lopuri... | Inclusion Criteria:
Three or more outpatient/ED visits in a 24-month period prior to selection for study with
one of these primary visit diagnoses:
- Gouty arthropathy
- Gout, unspecified
- Gout with other specified manifestations
- Tophaceous gout of ear... | Evaluating the Effectiveness of a Chronic Disease Management Program for Gout | NCT01568879 | Contradiction |
2,694 | 20 | A 49-year-old man comes to the office because of the bulging in his groin. Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases. His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications... | I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to... | Inclusion Criteria:
- 18 years old suffering unilateral,
- non -recurrent,
- un-complicated inguinal hernia.
Exclusion Criteria:
- previous abdominal or pelvic surgery,
- unfit with laparoscopic surgery,
- those with ascites,
- ... | Short Term Outcome of Laparoscopic Trans-abdominal Preperitoneal Inguinal Hernia Repair Without Mesh Fixation | NCT04532983 | Entailment |
5,467 | 40 | A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction. Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration. The patient has heavy menstrual cycles each month. She has no other medical problems and takes no medications... | I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical c... | Inclusion Criteria:
- Male or female;
- Age 18-75 years;
- vWD-2b - confirmed diagnosis, or;
- TTP Remission - prior episode(s) of primary acute TTP, or;
- Acute TTP - any episode, first or relapse, with presence of all of the following:
1. Mic... | ARC1779 Injection in Patients With Von Willebrand Factor-Related Platelet Function Disorders | NCT00632242 | Entailment |
4,264 | 32 | A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia. The patient is sexually active with his wife and does not use any contraception methods. They have been trying to conceive for the past year with no success. The patient has a past medical history of recurrent p... | I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet ... | Inclusion Criteria
1. Caucasian males defined as persons of a European or Latin American descent
2. Healthy male 30 to 55 years inclusive at the time of informed consent
3. Body mass index (BMI) of 18 to 32 kg/m2 at Screening
4. Subjects must have had a successful vasectomy (... | An Study to Determine the Bioavailability of E2609 Tablets Compared to Capsules and the Effect of Food on Absorption | NCT01716897 | Entailment |
5,719 | 42 | A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively. On physical examination, the patient's height is in the 5th percentile of her age. Other findings include low-set ears, a high arched palate... | I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a we... | Inclusion Criteria:
- Before starting treatment, the child is diagnosed as GHD according to medical
history,clinical symptoms and signs, GH provocation tests and imaging examinators and
other examinators.
- According to the height statistical data of Chinese children's ... | Clinical Study of Pegylated Somatropin to Treat Children Growth Hormone Deficiency | NCT02908958 | Entailment |
1,269 | 6 | A 61-year-old man comes to the clinic due to nonproductive cough and progressive dyspnea. The patient's medical conditions include hypertension, hypercholesteremia and peptic ulcer disease. He smokes 2 packs of cigarettes daily for the past 30 years. On examination, there are decreased breath sounds and percussive d... | I am 61 and I had to go to the clinic because I couldn't stop coughing and I experienced some breath shortness. I suffer from hypertension and cholesterol and I also have a stomach ulcer. I should admit that I've been smoking 2 packs of cigarettes every day for the past 30 years. My doctor told me that my breath in my ... | DISEASE CHARACTERISTICS: Histologically confirmed malignant mesothelioma of the pleura not
amenable to curative surgery Must be radiologically accessible Unidimensionally or
bidimensionally measurable disease Pleural effusions or positive bone scan not considered
measurable No brain metastases
... | Cisplatin With or Without Pemetrexed Disodium in Treating Patients With Malignant Mesothelioma of the Pleura That Cannot be Removed by Surgery | NCT00005636 | Entailment |
591 | 2 | A 32-year-old woman comes to the hospital with vaginal spotting. Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with ... | I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing... | Inclusion Criteria:
- have a positive serum or urine beta-human chorionic gonadotropin (hCG)
- estimated gestational age (EGA) of less than 20 weeks
- complaint of pelvic pain and/or vaginal bleeding
Exclusion Criteria:
- prior known documentation of an intrauter... | A Randomized Prospective Analysis of Time to Diagnosis and Length of Stay of Emergency Department Pelvic Ultrasonography | NCT02268877 | Entailment |
2,770 | 20 | A 49-year-old man comes to the office because of the bulging in his groin. Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases. His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications... | I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to... | Inclusion Criteria:
- male
- age: 18 - 65
- planned inguinal hernia repair using synthetic implant
- BMI range: 20-35 kg / m2
- written informed consent
Exclusion Criteria:
- prior midline laparotomy
- contraindications for gen... | Lichtenstein Versus TAPP and TEP in Groin Hernioplasty | NCT02928146 | Entailment |
1,034 | 4 | A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes. The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief. Past medical history is notable for hypertension and hypercholesteremia. ... | I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tyl... | Inclusion Criteria:
- Age ≥ 18 years
- Symptomatic HOA according to the American College of Rheumatology criteria
- Erosive HOA according to hand radiographs performed in routine practice showing ≥1
erosive digital joint based on Verbruggen-Veys scoring definition
... | Auricular Vagus Nerve Stimulation in Painful and Inflammatory Erosive Hand Osteoarthritis | NCT04520516 | Entailment |
1,732 | 10 | A 19-year-old girl comes to the clinic due to a left wrist mass. She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns. Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient n... | I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penli... | Inclusion Criteria:
- Hong Kong Chinese
- Computer users (computer usage >2hours/day)
- Spherical-equivalent refractive errors between plano and -9.00D and cylindrical power
≤2.50D
Exclusion Criteria:
- Anyone with visual acuity worse than 0 logMAR, ... | Effects of Wearing Progressive Addition Lens on Working Distance and Refractive Status in Adult Computer Users | NCT02775396 | Entailment |
3,683 | 29 | A 57-year-old man comes to the emergency department due to constipation. His last bowel movement was 2 days ago. He complains of spending about 30 minutes once attempting to defecate. He also has lower back pain. There is no history of trauma. The pain is not relieved with over-the-counter pain medications. His vita... | I'm a 57 year-old-man, and I had to go to the ER because I couldn't go defecate. My last trip to the toilet was 2 days ago, and I tried too many times, during 30 min, to get my poop to get out. I also have terrible lower back pain. The doctor did not notice any trauma. I tried to get the pain away using over-the-counte... | Inclusion Criteria:
1. Ability to give informed consent
2. Able to complete online or paper questionnaire.
3. Patients admitted to the regional neurosurgical unit, Western General Hospital,
Edinburgh with suspected cauda equina syndrome for an MRI scan. Demographic data fro... | BLB Study Back or Leg Pain and Bladder Symptoms Study | NCT03325374 | Entailment |
872 | 4 | A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes. The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief. Past medical history is notable for hypertension and hypercholesteremia. ... | I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tyl... | Inclusion Criteria:
- Aged 45 years and onward.
- Clinical diagnosis of knee arthritis with complaints of knee pain for 3-6 months,
early morning stiffness <30 minutes, crepitus, bony tenderness, and no palpable warmth
and radiographically established osteoarthritis (at... | Effects of Internet / Web-based Exercises on the Population With Knee Arthritis | NCT03545048 | Entailment |
3,380 | 25 | A 50-year-old woman comes to the clinic with intermittent ear discharge and sense of hearing loss on her left ear. Past medical history is significant for obesity, hyperlipidemia, and diabetes mellitus. Her medications include Metformin, Atorvastatin and Vit D supplement. Vital signs are normal. BMI is 37. Otoscopy s... | I went to the clinic the other day because I had some fluid in my ear and I felt like I could not hear as well as I used to in my left ear. I'm a 50-year-old woman, and I have been obese for a while now. I have diabetes and cholesterol. I take some medication. I take metformin, atorvastatin, and vitamin D supplements. ... | Inclusion Criteria:
- BMI 28-35
Exclusion Criteria:
- Severe disease
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 40 Years old.
Subject must be at most 65 Years | Dietary Advice on Prescription in Kungsbacka | NCT01385930 | Contradiction |
3,492 | 25 | A 50-year-old woman comes to the clinic with intermittent ear discharge and sense of hearing loss on her left ear. Past medical history is significant for obesity, hyperlipidemia, and diabetes mellitus. Her medications include Metformin, Atorvastatin and Vit D supplement. Vital signs are normal. BMI is 37. Otoscopy s... | I went to the clinic the other day because I had some fluid in my ear and I felt like I could not hear as well as I used to in my left ear. I'm a 50-year-old woman, and I have been obese for a while now. I have diabetes and cholesterol. I take some medication. I take metformin, atorvastatin, and vitamin D supplements. ... | Inclusion Criteria:
- Age 25-75 years old
- BMI between 25 and 42
Exclusion Criteria:
- Severe diseases
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 25 Years old.
Subject must be at most 75 Years | Severe Insulin Resistance in Patients With Type 2 Diabetes | NCT00654056 | Entailment |
988 | 4 | A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes. The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief. Past medical history is notable for hypertension and hypercholesteremia. ... | I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tyl... | Inclusion Criteria:
- Healthy men and women that have joint discomfort (WOMAC score >20)
Exclusion Criteria:
- Consumption of pharmacological treatments on an ongoing basis that may affect joint
mobility (chondroprotectors, corticoids and/or interarticular therapy or
... | Evaluation of a Combination of Plant Extracts (BSL_EP028) on Joint Mobility | NCT04029792 | Entailment |
2,265 | 15 | An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity m... | I brought my 8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weak... | Inclusion Criteria:
- Having a Duchenne Muscular Dystrophy diagnosis by a practicing physician,
- Between the ages of 8-16 years,
- Having lost ambulation ability,
- Brooke Upper Extremity Functional Classification (1-5)
- To have motivation and co-operation w... | Investigation Of Factors Affecting Hand Functions in Nonambulatory Patients With Duchenne Muscular Dystrophy | NCT03521271 | Contradiction |
2,271 | 15 | An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity m... | I brought my 8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weak... | Inclusion Criteria:
- Individuals diagnosed with DMD confirmed by molecular method and / or by protein
expression of skeletal muscle.
- Individuals undergoing clinical follow-up at the outpatient clinic for neuromuscular
diseases at the Federal University of São Paulo (... | Heart Rate Variability in Individuals With Duchenne Muscular Dystrophy | NCT04740554 | Contradiction |
3,652 | 28 | A 23-year-old woman comes to the emergency department with a history of nosebleeds lasting for 1 hour. She has a history of heavy menses as well as occasional gum bleeding following dental procedures. Her mother also has a history of menorrhagia. Laboratory tests reveal increased bleeding time and slightly increased pa... | I had to rush to the ER because of a non-stop nosebleed that had been on for 1 hour. As a 23-year-old, I always had heavy periods, and sometimes, my gums would bleed after going to the dentist or brushing my teeth. I thought that it was not very alarming since my mom also had heavy periods. I did some lab tests that sh... | Inclusion Criteria:
- Triaged as stage 3 or more (less acute)
Exclusion Criteria:
- Triaged as stage 2 or less (more acute), AND arriving for purposes of
forensic/criminal evaluations
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join t... | Subcutaneous Recombinant Human Hyaluronidase: Workflow Analysis and Emergency Department Design | NCT01020513 | Entailment |
4,622 | 35 | A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles. The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days. She is sexually active with her husband and... | I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of ... | Inclusion Criteria:
- adenomyosis
- request for contraception
- resident in the nearby vicinity to make the follow-up easy and feasible
Exclusion Criteria:
- history of ectopic pregnancy
- puerperal sepsis
- pelvic inflammatory disease
... | Levonorgestrel Intrauterine System and Adenomyosis | NCT03104309 | Entailment |
6,953 | 50 | A 70-year-old man comes to the office accompanied by his wife. The patient has experienced progressive memory loss over the last years. He needs help with some of his routine activities, such as paying bills. The patient's wife says, "He used to be such an independent person, but now he needs help with many things, ... | I am a 70-year-old man, and I paid a visit to the doctor with my wife the other day. I noticed that I tend to forget small things and that my memory has decreased over the past few years. I even ask my wife to help me out with my daily routine. I used to be the one paying the bills, but now she has to give me a hand. M... | Inclusion Criteria:
- patient suffering from mild to moderately severe Alzheimer's disease patients (MMSE 11
to 26)
- in community dwelling
- with an informal caregiver (person living with the patient or providing care 3 times a
week or 8 hours per week)
... | Impact of Therapeutic Educational Programme on the Alzheimer's Disease Affected Patient's Quality of Life | NCT01796314 | Entailment |
4,263 | 32 | A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia. The patient is sexually active with his wife and does not use any contraception methods. They have been trying to conceive for the past year with no success. The patient has a past medical history of recurrent p... | I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet ... | - INCLUSION CRITERIA:
1. 18 to 45 years of age, either male or female
2. Employees or non-employees are eligible
3. Normal screening examination:
1. history and physical examination, nonsmoker, no concurrent medications
includi... | Effects of Endotoxin in Normal Human Volunteers | NCT00001303 | Entailment |
6,263 | 46 | The patient is a 38-year-old man with cough and body ache that started 3 days ago. He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within n... | I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my tem... | Inclusion Criteria:
- Patients admitted to the hospital with symptoms of fever, sore throat, cough, nasal
congestion and/or dyspnea who were tested positive for SARS-CoV-2 by PCR
Exclusion Criteria:
- Patients of high clinical suspicion for COVID-19 with only one negative P... | Cardiovascular Manifestations of COVID-19 | NCT04335630 | Contradiction |
4,640 | 35 | A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles. The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days. She is sexually active with her husband and... | I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of ... | Inclusion Criteria:
- Healthy women aged 18 to 49 years
- Regular (21- to 35- day) menstrual cycles for the 3-month period preceding visit 1
- Must be sexually active and at risk for becoming pregnant.
Exclusion Criteria:
- Planned use of any other form of birth ... | Study Evaluating Levonorgestrel and Ethinyl Estradiol for Oral Contraception | NCT00245921 | Entailment |
3,002 | 22 | A 15-year-old boy with mild intellectual disability is brought to the office by his parents for a routine physical examination. The boy is going to a school for students with learning disabilities. The patient was adopted, and his immunizations are up to date. Review of the patient's medical records is notable for c... | My husband and I brought our 15-year-old son to the clinic for his routine exam. My son is going to school for special needs students. We adopted him a few years ago. His vaccinations are up to date. He already passed some chromosome testing and they found that he has a fragile X syndrome. The doctor told us that it co... | Inclusion Criteria:
- Abnormal phenotype: intellectual disability and/or multiple congenital anomalies.
- Post-natal cases
- ABCR diagnosed by standard karyotype, including reciprocal translocation, inversion,
insertion and Complex Chromosomal Rearrangement (CCR).
... | Apparently Balanced Chromosomal Translocation/ Next-generation Sequencing/ Intellectual Disability | NCT02451761 | Contradiction |
4,358 | 33 | A 20-year-old man comes to the clinic for his routine checkup. The patient wears glasses for myopia and takes no medications. Vital signs are normal. On physical examination, the patient is tall with long upper extremities and fingers. The face appears narrow with down-slanted palpebral fissures, flattened malar bon... | I'm a 20-year-old guy, working as a driver and I went to the clinic for my routine checkup. I have myopia, so I wear glasses and I don't take any other medications. My vitals were normal. I also did a physical exam, and I was told that I have long legs, arms, and fingers. They also told me that my face is quite narrow,... | Inclusion Criteria:
- healthy, 18 to 35 year old man or woman.
Exclusion Criteria:
- smoker
- pregnancy
- taking part in other research.
- followed a weight loss diet in the previous 6 months.
- history of gastrointestinal, endocrine, card... | The Effect of a Carbohydrate Drink on Cognitive Function and Exercise Performance | NCT02045342 | Entailment |
6,291 | 46 | The patient is a 38-year-old man with cough and body ache that started 3 days ago. He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within n... | I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my tem... | Inclusion Criteria:
- Patients with Covid 19 PCR (+) results
Exclusion Criteria:
- Cancer Patients
- Patients with known immunodeficiency
- Pregnancy
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years ... | Immune Cell Subgroups in Covid 19 Patients | NCT04531319 | Entailment |
3,920 | 30 | A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 chi... | I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 year... | Inclusion Criteria:
- Patient who met criteria (functional Class I-III in the hip or knee) for
osteoarthritis for at least 3 months before enrollment
- Patient who had moderate to severe chronic pain despite regular use and stable doses
of an NSAID (nonsteroidal anti-in... | An Effectiveness, Safety and Quality of Life Measures With Hydromorphone HCL, Dilaudid CR (Controlled Release) | NCT00399048 | Entailment |
4,244 | 32 | A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia. The patient is sexually active with his wife and does not use any contraception methods. They have been trying to conceive for the past year with no success. The patient has a past medical history of recurrent p... | I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet ... | Inclusion Criteria:
1. Males or females 7 years of age or older and able to perform pulmonary function
testing
2. Confirmed diagnosis of CF by the 1997 CF Consensus Conference criteria and followed by
the VCU or EVMS CF clinic
3. Presence of PA in 2 lower respi... | Aztreonam Aerosol to Treat Cystic Fibrosis Nasal Disease | NCT02730793 | Entailment |
3,878 | 30 | A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 chi... | I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 year... | Inclusion Criteria:
- Osteoarthritis of the knee
Exclusion Criteria:
- Other rheumatic disease, such as rheumatoid arthritis
- Active gastrointestinal ulcer during the last year
- Known allergy to analgesic drugs
- Other protocol defined inclusion/exc... | Efficacy and Safety of Diclofenac Sodium Gel (DSG) in Knee Osteoarthritis | NCT00426621 | Entailment |
5,324 | 40 | A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction. Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration. The patient has heavy menstrual cycles each month. She has no other medical problems and takes no medications... | I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical c... | Inclusion Criteria:
- Age between 35-49 years with regular heavy menstrual bleeding
- menstrual loss requiring more than 5 Pads/tampons per day
- menstrual cycle longer than 6 days
Exclusion Criteria:
- Organic causes of menorrhagia
- History of renal... | Trial of Homeopathy on Management of Menorrhagia | NCT01460043 | Contradiction |
1,362 | 8 | A 7-month-old boy is brought to emergency by his parents due to irritability and inability to defecate for the past 3 days. The patient has had constipation and discomfort with bowel movements since birth. His symptoms worsened after eating semi-solid foods. Vital signs are normal. Abdominal examination shows diste... | My baby boy just turned 7 months old but my wife and I cannot get a hold of him! He has not been able to poop for 3 days! My poor little thing has been having constipation and bowel problems since birth. But since he ate some semi-solid food it has just been worse! The doctor said his vitals are normal but his belly is... | Inclusion Criteria:
- Constipation
- Parental agreement
Exclusion Criteria:
- after surgery on lower gastrointestinal tract
- diagnosis of inflammatory bowel disease
- diagnosis of other disorder that may affect anorectum function
- parent... | 3D High Resolution Manometry and Balloon Expulsion Test in Diagnosis of Dyssynergic Defecation in Children | NCT02812836 | Contradiction |
2,976 | 22 | A 15-year-old boy with mild intellectual disability is brought to the office by his parents for a routine physical examination. The boy is going to a school for students with learning disabilities. The patient was adopted, and his immunizations are up to date. Review of the patient's medical records is notable for c... | My husband and I brought our 15-year-old son to the clinic for his routine exam. My son is going to school for special needs students. We adopted him a few years ago. His vaccinations are up to date. He already passed some chromosome testing and they found that he has a fragile X syndrome. The doctor told us that it co... | Inclusion Criteria:
- Patients with severe intellectual disability (IQ <35 ) or moderate (IQ <50) isolated
or syndromic presentation but undiagnosed . The diagnosis is established during
genetic counseling of a 6 CHU interregion
- Lack of family history ( parents). We a... | Inter-regional Project of the Great Western Exploration Approach for Exome Molecular Causes Severe Intellectual Disability Isolated or Syndromic | NCT02136849 | Contradiction |
1,440 | 9 | A 67-year-old woman comes to the clinic due to recent episode of choking, dysphagia, and cough. Her other medical problems include hypertension, dyslipidemia, and osteoarthritis. She does not smoke or use alcohol. She lives with her husband and she is able to do her own daily activities. She used to teach elementary ... | I'm a 67-year-old lady, and I went to the clinic due to nonstop choking, difficulty swallowing, and coughing. I also suffer from hypertension, cholesterol, and osteoarthritis. I do not smoke or drink alcohol. I live with my husband, and we are independent retired elementary school teachers. During the exam, my blood pr... | - INCLUSION CRITERIA FOR NORMAL VOLUNTEERS:
The normal volunteers will be without cardiac, pulmonary, neurological, otolaryngological,
psychiatric or speech, swallowing and hearing problems as determined by medical history and
examination by a physician.
EXCLUSION CRITERIA: SUBJECTS:
... | Electrical Muscle Stimulation to Aid Swallowing in Dysphagia | NCT00001936 | Contradiction |
3,524 | 26 | A 33-year-old woman comes to clinic complaining of progressive fatigue, decreased appetite, and 11-lb weight loss in the past 2 months. She uses levothyroxine because of the previously diagnosed Hashimoto disease. She has no other medical conditions and does not use tobacco, alcohol, or illicit drugs. Physical examin... | I went to the clinic because I was really suffering from fatigue and decreased appetite and I also lost 11 pounds over the past two months. I'm just 33 years old so that's not normal, especially for a woman. I take levothyroxine because I have been diagnosed with Hashimoto disease. I don't have any other medical condit... | Inclusion Criteria:
- Primary adrenal insufficiency under standard glucocorticoid replacement therapy due to
autoimmune adrenalitis or bilateral adrenalectomy (disease duration at least 12
months),
- age ≥ 18 years,
- Patient´s written informed consent,
... | Pharmacokinetics of Hydrocortisone After Subcutaneous Administration in Chronic Adrenal Insufficiency | NCT01450930 | Contradiction |
5,325 | 40 | A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction. Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration. The patient has heavy menstrual cycles each month. She has no other medical problems and takes no medications... | I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical c... | Inclusion Criteria:
- Any patient who had history of arecanut chewing habit with clinical manifestations of
OSMF.
- Patients who had arecanut chewing habit history of more than 1 year and had no
clinical symptoms of OSMF.
- Healthy human volunteers who are i... | Epithelial Mesenchymal Transition Markers in OSMF | NCT03732872 | Contradiction |
2,668 | 20 | A 49-year-old man comes to the office because of the bulging in his groin. Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases. His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications... | I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to... | Inclusion Criteria:
- Male patients
- Aged more than 18 years
- Primary inguinal hernia
Exclusion Criteria:
- Inguinoscrotal hernia
Male
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
| Comparison of Mesh Fixation Wit Cyanoacrylate vs Suture in Inguinal Hernia Surgery | NCT02197585 | Entailment |
2,666 | 20 | A 49-year-old man comes to the office because of the bulging in his groin. Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases. His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications... | I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to... | Inclusion Criteria:
- Clinical diagnosis of Inguinal Hernia
Exclusion Criteria:
- Cancer
- Pregnancy
- Chronic liver diseases
- Previous abdominal surgery history
- Femoral hernia
- Bilateral inguinal hernia
- Weight l... | Nutrition and Constipation at Inguinal Hernia Patients | NCT03937739 | Entailment |
4,710 | 35 | A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles. The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days. She is sexually active with her husband and... | I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of ... | Inclusion Criteria:
1. Good general health
2. Aged 18-44 years, inclusive, at the enrollment visit
3. Intact uterus with at least one ovary
4. Serum progesterone value ≥ 3 ng/mL at the Screening Visit (V0-P)
5. Pap test within the last 12 months or undergo a Pap te... | A Phase I Study to Evaluate the PK and PD of a Single Injection of Levonorgestrel Butanoate for Female Contraception | NCT02173808 | Entailment |
6,032 | 44 | A 48-year-old man comes to the office complaining of heartburn and acid reflux. He has taken over-the-counter antacids but sees no relief. Other medical history is unremarkable. The patient does not use tobacco, alcohol, or illicit drugs. Vital signs are within normal limits. BMI is 31 kg/m2. Physical examination... | I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old gu... | Inclusion Criteria:
- Adults ages 18-90
- Patients with heartburn and no hiatal hernia undergoing clinically indicated endoscopy
- Patients with heartburn and a hiatal hernia > 3cm undergoing clinically indicated
endoscopy
- Patients undergoing clinically ind... | [Impedance Measurement for Non-Erosive Reflux Disease | NCT02997527 | Entailment |
731 | 4 | A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes. The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief. Past medical history is notable for hypertension and hypercholesteremia. ... | I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tyl... | Inclusion Criteria:
1. Postmenopausal women aged over 18 with stage I-III breast cancer undergoing treatment
at the Lombardi Cancer Center.
2. Presence of hand pain
3. No active signs of ongoing malignant disease
Exclusion Criteria:
1. Known autoimmune d... | A Case Control Study to Define Clinical, Immunologic and Radiographic Features of the Aromatase Inhibitor Arthralgia Syndrome | NCT00890058 | Contradiction |
6,217 | 46 | The patient is a 38-year-old man with cough and body ache that started 3 days ago. He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within n... | I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my tem... | Inclusion Criteria:
1. Age between 18 and 60 years.
2. Health care worker in the front line of care of suspected or confirmed cases of
COVID-19.
3. Negative IgM antibodies.
Exclusion Criteria:
1. Being a participant in another trial with another drug.
... | Primary Prevention of Infection by COVID-19 in Health Providers | NCT04420260 | Contradiction |
5,657 | 42 | A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively. On physical examination, the patient's height is in the 5th percentile of her age. Other findings include low-set ears, a high arched palate... | I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a we... | Inclusion Criteria:
- Coming from the Lisbon region;
- A BMI ≥ p85 for gender and age;
- Attending the Clinic for the first time;
- Accepted to be enrolled.
Exclusion Criteria:
- Major pathologies (other than obesity or its related comorbidities);
... | Physical Activity Consultation in the Management of Adolescent Overweight | NCT02941770 | Contradiction |
1,431 | 9 | A 67-year-old woman comes to the clinic due to recent episode of choking, dysphagia, and cough. Her other medical problems include hypertension, dyslipidemia, and osteoarthritis. She does not smoke or use alcohol. She lives with her husband and she is able to do her own daily activities. She used to teach elementary ... | I'm a 67-year-old lady, and I went to the clinic due to nonstop choking, difficulty swallowing, and coughing. I also suffer from hypertension, cholesterol, and osteoarthritis. I do not smoke or drink alcohol. I live with my husband, and we are independent retired elementary school teachers. During the exam, my blood pr... | Inclusion Criteria:
- Age: 65-80 years
- Systolic blood pressure between 130-139 mmHg and diastolic blood pressure lower than
90 mmHg
- Non smoking
- Normal Body-Mass-Index (BMI): 18.5-24.9 kg·m-2
- Normal Lung Function
- Willing to ad... | Respiratory Muscle Training and Intermittent Hypoxia: Additive Health Effects? | NCT03313284 | Contradiction |
3,262 | 23 | A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn. The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness. She also reports occasional joint pain. Medical history... | I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to t... | Inclusion Criteria:
- Male or female
- More than 18 years old
- Consulting in Doppler unit for sicca syndrome or suspicion of Sjögren syndrome
- Consent agreement
Exclusion Criteria:
- No consent agreement
- No sicca symptoms
No condition ... | Ultrasound Elastography of Salivary Glands | NCT02994797 | Entailment |
9 | 1 | A 19-year-old male came to clinic with some sexual concern. He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates. On physical examination, there is some pubic hair and poo... | I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me sm... | - INCLUSION CRITERIA:
1. Men age 65 years or older
2. Serum testosterone level less than or equal to 350 ng/dl
3. Subject is able to complete an informed consent
EXCLUSION CRITERIA:
1. History of Stroke
2. History of Dementia
3. ... | The Effects of Aromatase Inhibition and Testosterone Replacement in Sex Steroids, Pituitary Hormones, Markers of Bone Turnover, Muscle Strength, and Cognition in Older Men | NCT00104572 | Contradiction |
4,577 | 35 | A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles. The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days. She is sexually active with her husband and... | I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of ... | Inclusion Criteria
To enroll into the clinical trial, potential subjects must:
1. Be healthy women, who are sexually active, at risk for pregnancy and desiring
contraception.
2. Be within the age range of 18 through 40 years inclusive at enrollment.
3. Have a negat... | A Multicenter, Open-Label, Non-Comparative Study of the Safety and Contraceptive Efficacy of the Woman's Condom | NCT01223313 | Contradiction |
886 | 4 | A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes. The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief. Past medical history is notable for hypertension and hypercholesteremia. ... | I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tyl... | Inclusion Criteria:
- Knee pain and minimum three of the following
- >50 years
- morning stiffness < 30 min
- crepitation
- bone tenderness
- bone osteophytes
- absence of inflammation
Exclusion Criteria:
- Other ca... | Variable Resistance Training in Patients With Osteoarthrosis of the Knee | NCT03722277 | Entailment |
4,824 | 37 | A 47-year-old man comes to the office due to weight gain and fatigue. He is not able to lift heavy objects or climb stairs. Family history is positive for DM type 2 and HTN in his father. Blood pressure is 165/90 mm Hg and pulse is 85/min. On physical examination, there is symmetric proximal muscle weakness of the u... | I'm a 47-year-old man. I went to the clinic because I had been gaining weight and had increased fatigue over the past few weeks. I was not able to lift heavy objects or even climb the stairs. My dad was diagnosed with type 2 diabetes and high blood pressure. During the exam, they took my blood pressure, which was 165/9... | Inclusion Criteria:
Inclusion Criteria
1. Patient is a recipient of a first cadaveric kidney, or a kidney living donor
mismatched (at least one mismatch.)
2. Patient is a minimum of 18 years of age at the time of transplant.
3. Patient has type 2 non-insulin depend... | Immunosuppression Impact on the Metabolic Control of Kidney Transplant With Pre-Existing Type 2 Diabetes (DM) | NCT00296296 | Contradiction |
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