id int64 3 7.01k | topic_id int64 1 50 | statement_medical stringclasses 50
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values | premise stringlengths 111 17k | NCT_title stringlengths 18 299 | NCT_id stringlengths 11 11 | label stringclasses 2
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5,151 | 39 | A 55-year-old white woman comes for a routine checkup. She has no significant medical history and does not use tobacco, alcohol, or illicit drugs. The patient's only medication is an over-the-counter multivitamin. Family history is notable for a hip fracture in her mother. Blood pressure is 130/80 mm Hg and pulse i... | I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse w... | Inclusion Criteria:
i) osteopenic postmenopausal Caucasian women following Dmab treatment ii) assignment to
treatment with alendronate in an effervescent tablet formulation following Dmab
discontinuation
Exclusion Criteria:
i) secondary osteoporosis; ii) diseases that could af... | Alendronate in an Weekly Effervescent Tablet Formulation Following Denosumab Discontinuation | NCT04338529 | Contradiction |
1,720 | 10 | A 19-year-old girl comes to the clinic due to a left wrist mass. She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns. Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient n... | I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penli... | Inclusion Criteria:
- men and women, aged 18-55 years
- who are able to read and write
- who are able to give voluntary written informed consent
- have no current uncontrolled medical condition such as neurological, cardiovascular,
endocrine, renal, liver, or... | Test-retest Reproducibility of [11C]PHNO PET Using the Constant Infusion Paradigm | NCT01699607 | Entailment |
4,693 | 35 | A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles. The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days. She is sexually active with her husband and... | I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of ... | Inclusion Criteria:
- Premenopausal (defined by having had menstruation the last six month)
- If amenorrhea with levonorgestrel intrauterine device, the woman should be < 45 years
old
- Hysterectomy planned due to a benign condition
- Hysterectomy does not re... | Validation of the Adenomyosis Calculator | NCT04135118 | Entailment |
1,301 | 7 | A 3-year-old girl is brought to the clinic by her parents for assessment of her short stature. Physical examination reveals short limbs and a relatively large head. She has a flat nasal bridge and a small midface. The girl's father exhibits similar physical features; however, her mother looks normal. The genetic testin... | I just brought my little 3-year-old girl to the clinic to have her checked up by the doctor. I was worried sick because she was smaller than her classmates. The lovely doctor performed a physical exam and she told me that she has short limbs and a larger head. My girl also has a flat nasal bridge and a small midface. M... | Inclusion Criteria:
1. Must have completed Study 111-206 on investigational treatment (BMN 111 or placebo).
2. Parent(s) or guardian(s) are willing and able to provide written, signed informed
consent after the nature of the study has been explained and prior to performance of
... | An Extension Study to Evaluate Safety and Efficacy of BMN 111 in Children With Achondroplasia | NCT03989947 | Contradiction |
6,029 | 44 | A 48-year-old man comes to the office complaining of heartburn and acid reflux. He has taken over-the-counter antacids but sees no relief. Other medical history is unremarkable. The patient does not use tobacco, alcohol, or illicit drugs. Vital signs are within normal limits. BMI is 31 kg/m2. Physical examination... | I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old gu... | Inclusion Criteria:
The patients to be included will be outpatients who meet all of the following criteria. No
specific gender is asked.
<For the observation period>
1. Patients who have "heartburn" 2 days a week or more for consecutive weeks during 3
weeks prior to pre... | A Comparative Study on the Efficacy and Safety of E3810 in Patients With Non-erosive Gastroesophageal Reflux Disease | NCT00165646 | Entailment |
3,956 | 30 | A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 chi... | I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 year... | Inclusion Criteria:
- Able to provide written informed consent to participate in the study
- Willing and able to comply with all study requirements and instructions of the site
study staff
- Male or female, 40 years to 85 years old (inclusive)
- Must be ambul... | AP-003-A A Efficacy and Safety Study of Two Doses of Intra-Articular Injection of Ampion™ in Adults With Pain Due to Osteoarthritis of the Knee | NCT01839331 | Entailment |
5,149 | 39 | A 55-year-old white woman comes for a routine checkup. She has no significant medical history and does not use tobacco, alcohol, or illicit drugs. The patient's only medication is an over-the-counter multivitamin. Family history is notable for a hip fracture in her mother. Blood pressure is 130/80 mm Hg and pulse i... | I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse w... | Inclusion Criteria:
- Postmenopausal for ≥5 years (defined as no menses for at least 5 years or at least 5
years post bilateral oophorectomy).
- Prior or current treatment with oral bisphosphonate therapy (i.e., alendronate,
risedronate, ibandronate) for postmenopausal ... | Efficacy and Safety of Odanacatib in Postmenopausal Women Previously Treated With Oral Bisphosphonate (MK-0822-076) | NCT01803607 | Contradiction |
1,729 | 10 | A 19-year-old girl comes to the clinic due to a left wrist mass. She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns. Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient n... | I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penli... | Inclusion Criteria:
- No prior wrist or elbow injuries on the dominant side of his/her body
- Ability to complete study in one sitting of 90-120 minutes
- Between the ages of 18 years and 100 years
- Ability to follow directions and speak and read English
Exclusi... | A Comparison Study of Three Standard Elbow Wrist Hand Orthoses to Limit Forearm Rotation | NCT04130425 | Entailment |
5,140 | 39 | A 55-year-old white woman comes for a routine checkup. She has no significant medical history and does not use tobacco, alcohol, or illicit drugs. The patient's only medication is an over-the-counter multivitamin. Family history is notable for a hip fracture in her mother. Blood pressure is 130/80 mm Hg and pulse i... | I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse w... | Inclusion Criteria:
- recent proximal 2-segment humerus fracture (0-8 days post fracture)
- no surgical treatment at fractured site
- signed informed consent
- postmenopausal female and male patients aged 60 - 85 years
- established osteoporosis as defined by ... | Teriparatide for Fracture Repair in Humans | NCT02091492 | Contradiction |
4,060 | 30 | A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 chi... | I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 year... | Inclusion criteria:
Inclusion Criteria for OA patients:
Study participant will be recruited from rheumatology outpatient clinics and primary care:
1. fulfilling the American College of Rheumatology (ACR) criteria for the diagnosis of
knee osteoarthritis
2. male or fe... | Understanding Pain Perception in Osteoarthritis | NCT02603939 | Entailment |
3,192 | 23 | A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn. The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness. She also reports occasional joint pain. Medical history... | I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to t... | Inclusion Criteria:
- Confirmed diagnosis of moderate to severe dry eye associated with either
Graft-versus-host disease (GVHD), Sjogren syndrome, idiopathic dry eyes, or minimal
limbal cell deficiency
- A baseline Schirmer tear test (1) of less than 5 mm at 5 minutes w... | Senofilcon A Lenses in Moderate to Severe Dry Eye Disease | NCT04096898 | Entailment |
3,440 | 25 | A 50-year-old woman comes to the clinic with intermittent ear discharge and sense of hearing loss on her left ear. Past medical history is significant for obesity, hyperlipidemia, and diabetes mellitus. Her medications include Metformin, Atorvastatin and Vit D supplement. Vital signs are normal. BMI is 37. Otoscopy s... | I went to the clinic the other day because I had some fluid in my ear and I felt like I could not hear as well as I used to in my left ear. I'm a 50-year-old woman, and I have been obese for a while now. I have diabetes and cholesterol. I take some medication. I take metformin, atorvastatin, and vitamin D supplements. ... | Criteria Inclusion:
- age> 18 years,
- patients with type 2 diabetes mellitus diagnosis;
- able to express consent to the study.
Exclusion Criteria:
- Nobody
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
| New Patient Support Program in Type 2 Diabetes | NCT03752567 | Entailment |
5,986 | 44 | A 48-year-old man comes to the office complaining of heartburn and acid reflux. He has taken over-the-counter antacids but sees no relief. Other medical history is unremarkable. The patient does not use tobacco, alcohol, or illicit drugs. Vital signs are within normal limits. BMI is 31 kg/m2. Physical examination... | I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old gu... | Inclusion Criteria:
- All Adult patients with clinically diagnosed with Gastroesophageal Reflux Disease
(GERD) without alarm features (heartburn and acid regurgitation)
- Age more than 18 years at the time of written consent
- Those who provide written consent with their... | Effectiveness of Vonoprazan vs Omeprazole as Empiric Therapy for Gastroesophageal Reflux Disease (GERD) Patients Without Alarm Features | NCT04028466 | Entailment |
5,186 | 39 | A 55-year-old white woman comes for a routine checkup. She has no significant medical history and does not use tobacco, alcohol, or illicit drugs. The patient's only medication is an over-the-counter multivitamin. Family history is notable for a hip fracture in her mother. Blood pressure is 130/80 mm Hg and pulse i... | I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse w... | Inclusion Criteria:
- Patients with osteoporosis (T-score values below -2.5)
Exclusion Criteria:
- Patients with a history of tumors, ovariectomy, heart disease, renal failure, disc
prolapse, or any trauma to the back area
No condition on gender to be admitted to the trial.... | Effect of Class IV Laser Therapy and Pilates Exercises on Bone Density and Pain in Primary Osteoporosis: A Randomized Controlled Trial | NCT04646863 | Entailment |
3,909 | 30 | A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 chi... | I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 year... | Inclusion Criteria:
Patients diagnosed with knee OA according to the criteria of the American College of
Rheumatology (ACR), and were considered as stage 2 and 3 according to Kellgren-Lawrence
criteria.
Exclusion Criteria:
Exclusion criteria were previous knee surgery, maligna... | A Better Way to Decrease Knee Swelling in Patients With Knee Osteoarthritis | NCT03806322 | Entailment |
3,285 | 23 | A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn. The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness. She also reports occasional joint pain. Medical history... | I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to t... | Inclusion Criteria:
- IgG4-related disease patients or
- Sjogren syndrome patients or
- Healthy subjects
Exclusion Criteria:
- Presence of autoimmune or inflammatory associated disease
- Age less than 18 years
No condition on gender to be admitted to ... | Follicular Helper T Cells: Biological Marker and Involvement in the Physiopathology of the IgG4-related Disease | NCT02899039 | Entailment |
6,525 | 48 | A 20-year-old man comes to the emergency due to bleeding after a tooth extraction. The bleeding has persisted for approximately 30 minutes despite constant direct pressure. He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family histo... | I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove... | Inclusion Criteria:
1. Have a diagnosis of hemophilia A or B with inhibitors.
2. Be 12 - 65 years of age inclusive
3. Be capable of understanding and willing to comply with the conditions of the protocol
or have a legal guardian who is capable of understanding and complying... | SEVENFACT® for Bleeding Events in Hemophilia With Inhibitors | NCT04647227 | Contradiction |
2,987 | 22 | A 15-year-old boy with mild intellectual disability is brought to the office by his parents for a routine physical examination. The boy is going to a school for students with learning disabilities. The patient was adopted, and his immunizations are up to date. Review of the patient's medical records is notable for c... | My husband and I brought our 15-year-old son to the clinic for his routine exam. My son is going to school for special needs students. We adopted him a few years ago. His vaccinations are up to date. He already passed some chromosome testing and they found that he has a fragile X syndrome. The doctor told us that it co... | Inclusion Criteria:
- Known or suspected allergy to fish with either positive specific s-IgE or skin prick
test to one or more fish species
- Either positive specific s-IgE or spin prick test to one or more fish species and
never eaten fish.
Exclusion Criteria:... | Allergy Against Different Species of Fish in Children and Adolescents Allergic to Fish | NCT02365168 | Contradiction |
1,026 | 4 | A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes. The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief. Past medical history is notable for hypertension and hypercholesteremia. ... | I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tyl... | Inclusion Criteria:
Patients must elicit 3 of the 6 symptoms to be included:
- forty five years of age and over.
- stiffness for less than thirty minutes;
- crepitus;
- bony tenderness;
- bony enlargement;
- no palpable joint warmth.
... | Mixed Methods Assessment of Exercises for Knee OA | NCT02734342 | Entailment |
1,646 | 10 | A 19-year-old girl comes to the clinic due to a left wrist mass. She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns. Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient n... | I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penli... | Inclusion Criteria:
- ages 18-60 years old
- Control group: normal, healthy volunteers
- Amputee group: unilateral, transradial myoelectric prosthesis users
Exclusion Criteria:
- elderly > 60
- children < 18
- pregnant women
- ... | Study of Compensatory Motion While Using an Upper Limb Prosthesis | NCT00417352 | Entailment |
6,706 | 48 | A 20-year-old man comes to the emergency due to bleeding after a tooth extraction. The bleeding has persisted for approximately 30 minutes despite constant direct pressure. He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family histo... | I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove... | Inclusion Criteria:
- Age: 18 to 75 years
- Gender: No restriction
- Subjects must require a single-rooted tooth extraction (Tooth deemed as periodontally
and/or restoratively hopeless) in the maxillary anterior region (first premolar to
first premolar)
... | Periodontal Phenotype Study (Tooth Extraction) | NCT02668289 | Contradiction |
150 | 1 | A 19-year-old male came to clinic with some sexual concern. He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates. On physical examination, there is some pubic hair and poo... | I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me sm... | Inclusion Criteria:
- Male sex
- Age between 18 and 45 years
- Acquired HH forms
- HH after neurosurgery for tumors (i.e. pituitary adenoma, including prolactinoma,
craniopharyngioma, germinomas, meningiomas, gliomas, and astrocytomas). Infiltrative
... | Rec-LH PD and Safety Profile in Hypogonadotropic Hypogonadism Men | NCT04189133 | Entailment |
2,558 | 19 | A 7-year-old girl is brought to the emergency department by her parents for generalized rash. The mother reports that she was playing outside wearing a skirt and felt a sharp pain in her arm while seating on a mat, plying with her doll. Her mother suspects that something had stung her. The patient's blood pressure ... | I just brought my seven-year-old girl to the ER because she just developed a terrible rash. My little girl was playing outside and she was wearing a lovely little skirt and all of a sudden. She felt like a really sharp pain in her arm. She was sitting on a mat playing with her doll. I think that something stung her. Th... | Inclusion Criteria:
- Children aged 1 day to 18 years presenting to the ED.
Exclusion Criteria:
1. Serious medical condition requiring emergent medical care or resuscitation
2. Parental refusal to participate in the study
No condition on gender to be admitted to the trial.
Acc... | The Effect of Medical Clowns on Blood Pressure Measurement in Children Presenting to the Emergency Department | NCT03143088 | Entailment |
3,604 | 28 | A 23-year-old woman comes to the emergency department with a history of nosebleeds lasting for 1 hour. She has a history of heavy menses as well as occasional gum bleeding following dental procedures. Her mother also has a history of menorrhagia. Laboratory tests reveal increased bleeding time and slightly increased pa... | I had to rush to the ER because of a non-stop nosebleed that had been on for 1 hour. As a 23-year-old, I always had heavy periods, and sometimes, my gums would bleed after going to the dentist or brushing my teeth. I thought that it was not very alarming since my mom also had heavy periods. I did some lab tests that sh... | Inclusion Criteria:
- Young women aged 12 to 25 years living in Beni-Suef city of Egypt. the urban
Metropolitan of Beni-Suef City was classified according to the socioeconomic level of
its quarters to low, middle, and high levels. Out of each level, one quarter was
sel... | Prevalence of Female Circumcision Among Young Women in Beni-Suef, Egypt | NCT03381612 | Entailment |
6,461 | 47 | A 41-year-old woman comes to the dermatology clinic complaining of facial redness, especially on her forehead and cheeks. She noticed that the redness gets worse in the summer and after sun exposure. She is otherwise healthy. On physical examination, she has multiple papules and pustules present on her forehead, cheeks... | I'm 41, married with 2 lovely kids who are 5 and 9 years old. I have an IUD and I don't want to have more kids. I don't smoke or drink alcohol. I had to go to the dermatology clinic because I had terrible redness on my face, especially on my forehead and cheeks. It got worse in the summer and after being under the sun.... | Inclusion Criteria:
- Have persistent facial erythema on the cheeks of at least moderate severity.
- Women must not be able to bear children
Exclusion Criteria:
- Have more than 12 inflammatory lesions on the face
- Previous treatment of facial skin with lasers o... | Safety, Tolerability and Efficacy of BFH772 in Rosacea Patients | NCT01449591 | Entailment |
5,034 | 38 | A 60-year-old man comes to the clinic complaining of hand tremor that started few months ago. It is most bothering when he wants to drink from a glass or pour from a bottle. He does not smoke, but drinks occasionally. He recently started consuming more alcohol as his tremor subsides somewhat when he drinks small amoun... | I'm only a 60 years old man but I already suffer from shaky hands. It started a few months ago, and it really bothers me when I want to pour myself a glass or even while drinking. I don't smoke, but I drink alcohol from time to time. To be honest, I've been drinking a little more lately since it helps me with the shaki... | Inclusion Criteria:
- Clinical diagnosis of Parkinson's Disease
- Presence of PD-related tremor
- Currently using Cannabis for management of tremor
- Obtaining Cannabis in accordance with Washington State law
- Willing to log activities and experiences
... | Cannabis and Parkinson's Disease Tremor: A Natural History Study | NCT02028858 | Entailment |
2,217 | 14 | A 39-year-old man comes to the emergency department with an acute onset of severe left toe pain. The toe is red and exhibits swelling. The patient is not febrile, and does not remember any recent trauma. Medical history is not significant except for the similar attacks and the diagnosis of gouty arthritis. His medicat... | I'm a 39-year-old man and got admitted to the ER after an unbearable pain in my left toe. My toe was red and terribly swollen. I was still standing on my feet, not febrile and I don't remember hitting my head or anything. I don't have any special medical history, but I had been diagnosed with gout before. I take Lopuri... | Inclusion Criteria:
- (123 items and 1 item from 4-7 are met simultaneously) :
1. Meet the 2015 ACR/EULAR classification diagnostic criteria for gout
2. Acute gouty arthritis
3. Age ≥18
4. Repeated attacks and prolonged pain (more than 1 month)... | Treatment of Refractory Gout With ACTH or Methylprednisolone | NCT04808856 | Contradiction |
1,054 | 5 | A 23-year-old man comes to the emergency department following an episode of syncope. He was working out when he felt dizzy and passed out without head injury. He has had 3 other episodes of light-headedness over the last year, all happening during physical activity. He never had this experience while resting. He has ... | I'm 23, and I got admitted to the ER because I fainted all of a sudden. I was in the gym, working out, when all of a sudden, I just got dizzy and passed out. Hopefully, I didn't hit my head. It's not my first time having that kind of dizziness at the gym, never when I'm chilling at home tho. I don't have any special me... | Inclusion Criteria:
- Subjects with heart failure and at the age of 18 (inclusive) to 80 (exclusive)
- Subjects with NYHA Class II-IV with dyspnea
- Subjects with left ventricular ejection fraction (LVEF) of 40 percent or below on the
echocardiogram
- Eligibl... | A Prospective, Open-labeled, Multi-centric Trial in Subjects With Systolic Heart Failure to Evaluate Bisoprolol Treatment for the Effects on Surrogate Markers of Heart Failure in Korea | NCT01074307 | Contradiction |
428 | 2 | A 32-year-old woman comes to the hospital with vaginal spotting. Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with ... | I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing... | Inclusion Criteria:
- Woman is between 18 and 40 years of age
- Has intact uterus and ovaries
- Has regular menstrual cycles of 25-35 days duration
- Able to comply with the protocol, including frequent blood sampling, and lives within
the catchment area of t... | A Phase 2, Dose-finding, Cross-over Study to Evaluate the Effect of a NES/E2 Transdermal Gel Delivery on Ovulation Suppression in Normal Ovulating Women | NCT00796133 | Contradiction |
3,739 | 30 | A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 chi... | I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 year... | Inclusion Criteria:
- Radiographic evidence of knee OA on a standing AP X-ray
- Bilateral knee pain for at least 3 months with pain of at least moderate intensity
every day or almost every day
Exclusion Criteria:
- Non-ambulatory, or severely impaired mobility (... | Osteopuncture for Osteoarthritis-Associated Knee Pain & Disability | NCT00417313 | Contradiction |
5,271 | 39 | A 55-year-old white woman comes for a routine checkup. She has no significant medical history and does not use tobacco, alcohol, or illicit drugs. The patient's only medication is an over-the-counter multivitamin. Family history is notable for a hip fracture in her mother. Blood pressure is 130/80 mm Hg and pulse i... | I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse w... | Inclusion Criteria:
- postmenopausal women with ages range from 50 to 60 years
Exclusion Criteria:
- participation in sports
- vertebrobasillar insufficiency
- poor diet
Female
Subject must be at least 50 Years old.
Subject must be at most 60 Years | Relationships Among Body Mass Index, Body Balance and Bone Mineral Density in Postmenopausal Women | NCT03280693 | Entailment |
6,707 | 48 | A 20-year-old man comes to the emergency due to bleeding after a tooth extraction. The bleeding has persisted for approximately 30 minutes despite constant direct pressure. He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family histo... | I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove... | Inclusion Criteria:
- a single tooth to be extracted for endodontic failure, fractures, root caries or
resorption in the maxillary and mandibular area from second premolar to second
premolar
- patient in good systemic health, with no contraindication for oral surgical
... | Soft and Hard Tissue Changes After Immediate Single-tooth Replacement | NCT03784430 | Contradiction |
2,457 | 16 | A 39-year-old woman comes to the clinic complaining of arthralgias and nodules on her legs. She has no fever or other skin rashes. The prior medical condition is unremarkable, and she takes no medications. On physical examination, there is moderate hepatomegaly. The lesions on her legs are tender and present predomin... | I'm just a 39-year-old young woman but lately I have noticed some underlying cysts on my legs and my joints were hurting so much. I don't have a fever. I don't have rashes. My medical history is totally clean and I don't take any medication. When I went to the clinic they did a physical examination where they found tha... | Inclusion Criteria:
- diagnosed sarcoidosis according to WASOG/ATS/ERS guidelines
Exclusion Criteria:
- not being able to walk
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
| Muscle Strength and Exercise Capacity in Sarcoidosis Patients | NCT00854672 | Entailment |
5,711 | 42 | A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively. On physical examination, the patient's height is in the 5th percentile of her age. Other findings include low-set ears, a high arched palate... | I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a we... | Inclusion Criteria:
- All patients who receive easypod GH of age 1-14 years will be approached for consent
to participate in the study. Patients may have any valid cause for short stature.
These may include children with
- isolated growth hormone deficiency
-... | Web-based Adherence Information Integrated Nurse-led Monitoring Clinic | NCT04244123 | Entailment |
6,857 | 50 | A 70-year-old man comes to the office accompanied by his wife. The patient has experienced progressive memory loss over the last years. He needs help with some of his routine activities, such as paying bills. The patient's wife says, "He used to be such an independent person, but now he needs help with many things, ... | I am a 70-year-old man, and I paid a visit to the doctor with my wife the other day. I noticed that I tend to forget small things and that my memory has decreased over the past few years. I even ask my wife to help me out with my daily routine. I used to be the one paying the bills, but now she has to give me a hand. M... | Inclusion Criteria:
- AD diagnosis or AD with CVD according the criteria of National Institute on Aging and the
Alzheimer's Association workgroup and the National Institute of Neurological and
Communicative Disorders and Stroke and the Alzheimer's Disease and Related Disorders
Associati... | The Predictive Factors of Good Clinical Response to Cholinesterase Inhibitors in Alzheimer Disease and Mixed Dementia | NCT02187276 | Contradiction |
3,237 | 23 | A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn. The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness. She also reports occasional joint pain. Medical history... | I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to t... | Inclusion Criteria:
- primary or scondary Sjogren's syndrome
Exclusion Criteria:
- allergy to milk derivatives previous intake of antifungals
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 30 Years old.
Subjec... | Probiotics as a Prophylaxis to Prevent Clinical Manifestations of Oral Candidosis in Patients With Sjogren's Syndrome | NCT03840538 | Entailment |
6,221 | 46 | The patient is a 38-year-old man with cough and body ache that started 3 days ago. He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within n... | I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my tem... | Inclusion Criteria:
- Documented COVID-19 infection (either performed on site or documented external report)
- Age ≥ 18
Arm A:
- Admission to an intensive care unit at MSK (M-11) and/or receiving mechanical
ventilation
- Absolute lymphocyte count ≤ 1... | A Study of N-acetylcysteine in Patients With COVID-19 Infection | NCT04374461 | Contradiction |
654 | 3 | A 51-year-old man comes to the office complaining of fatigue and some sexual problems including lack of libido. The patient doesn't smoke or use any illicit drug. Blood pressure is 120/80 mm Hg and pulse is 70/min. Oxygen saturation is 99% on room air. BMI is 24 kg/m2. Skin examination shows increased pigmentation.... | I am 51 years old and I just came back from the doctor's office. I'm sick and tired of being that exhausted, reaching the point where me and my lovely wife are not touching each other anymore! I'm not smoking or doing drugs! My blood pressure was 120/80 mm Hg, and pulse was 70/min and my oxygen saturation 99%. My BMI i... | Inclusion Criteria:
1. Age >18 years
2. Previous clinical diagnosis of heart failure with current New York Heart Association
(NYHA) Class II-IV symptoms LVEF≤0.40 within 2 years prior to consent, and ≥3 months
after a major change in cardiac status (i.e. CABG or CRT).
... | Oral Iron Repletion Effects On Oxygen Uptake in Heart Failure | NCT02188784 | Contradiction |
5,787 | 43 | A 27-year-old woman comes to the dermatology clinic with skin rash and oral ulcers. The rashes are mildly itchy. The patient has no other medical conditions and takes no medications. Vital signs are normal. On examination, there are pink papules symmetrically distributed over the anterior surfaces of the shins and a... | I went to the dermatologist because I had rashes on my skin and ulcers in my mouth. The rashes were not that itchy. I don't get it! I'm 27, I don't take medication, nor I don't have any other illnesses. My vitals were normal. My doc told me there were pink spots on the back of my throat. I'm heterosexual and have been ... | Inclusion Criteria:
- DSM-IV diagnosis of nicotine dependence with psychological dependence
- Smokes at least 15 cigarettes per day for the three months prior to enrollment
- Currently not seeking treatment for nicotine dependence
- Medically healthy on the basis of physi... | The Effects of Memantine and Bupropion on Acute, Reinforcing, and Conditioned Effects of Cigarettes - 1 | NCT00136747 | Contradiction |
3,206 | 23 | A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn. The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness. She also reports occasional joint pain. Medical history... | I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to t... | - INCLUSION CRITERIA:
1. Diagnosis of primary Sjogren s syndrome based on American-European Consensus
Group Sjogren s syndrome classification criteria or healthy volunteers.
2. Both genders and all minorities.
3. Age at entry at least 18 and less than 6... | Evaluation of the Role of the Autonomic Nervous System in Sj(SqrRoot)(Delta)Gren s Syndrome | NCT00565526 | Entailment |
2,831 | 21 | A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year. Over the last few months, he has also noticed weakness in the right upper extremity. BP is 120/75, PR is 80 and temperature is 37 C. Reflex... | I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rat... | Inclusion Criteria:
- ALS
- FVC >=50%
- Abnormality in upper and/or lower extremity motor function
- Not pregnant
- Disease duration <5 years
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at... | Clinical Trial of Creatine in Amyotrophic Lateral Sclerosis | NCT00005766 | Entailment |
6,157 | 46 | The patient is a 38-year-old man with cough and body ache that started 3 days ago. He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within n... | I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my tem... | Inclusion Criteria:
- Hospitalized at the Kantonsspital Winterthur (KSW) due to COVID-19 infection
(laboratory-confirmed),
- with or without mechanically assisted ventilation
- being at risk to obtain severe illness caused by the COVID-19*
- in... | Quality of Life and Physical Performance After Novel Coronavirus Infection (COVID-19); | NCT04375709 | Contradiction |
6,394 | 46 | The patient is a 38-year-old man with cough and body ache that started 3 days ago. He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within n... | I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my tem... | Inclusion Criteria:
1. Age 18 and older.
2. Symptoms suggestive of Covid-19 infection (fever, cough, chest discomfort or loss of
smell/taste).
3. Covid-19 screening done.
4. Ambulatory without assistive devices (such as cane or walker).
5. Access to PT... | Home-Based Covid-19 Rehabilitation Program | NCT04406532 | Entailment |
432 | 2 | A 32-year-old woman comes to the hospital with vaginal spotting. Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with ... | I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing... | Inclusion Criteria:
- pregnant women between 20-40 years. Pregnancy between 6-10 weeks. single intrauterine
spontaneous pregnancy. vaginal bleeding or bloody vaginal discharge with or without
pelvic pain for patients with threatened miscarriage.
Exclusion Criteria:
... | Value of CA125 and Yolk Sac Morphology in Prediction of Pregnancy Outcome in Threatened Miscarriage | NCT03320213 | Contradiction |
3,718 | 30 | A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 chi... | I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 year... | Inclusion Criteria:
Subjects will include those for whom a discontinuation trial of NSAIDs is most appropriate:
1) Veterans with knee pain despite NSAID use and/or 2) Veterans at relatively higher risk
of NSAID toxicity 55-59 as ascertained by meeting 1 or more of the following 4 criteria:
... | Discontinuing NSAIDs in Veterans With Knee Osteoarthritis | NCT01799213 | Contradiction |
5,193 | 39 | A 55-year-old white woman comes for a routine checkup. She has no significant medical history and does not use tobacco, alcohol, or illicit drugs. The patient's only medication is an over-the-counter multivitamin. Family history is notable for a hip fracture in her mother. Blood pressure is 130/80 mm Hg and pulse i... | I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse w... | Inclusion Criteria:
1. Subject is willing to provide written informed consent.
2. Ambulatory woman between the age of 50 and 85 years, inclusive.
3. The subject has a BMD absolute value consistent with a T-score<-2.5 and >-4.0 at
either the lumbar spine or total hip
... | Efficacy and Safety of QL1206 in the Treatment of Postmenopausal Osteoporosis With High Fracture Risk | NCT04128163 | Entailment |
2,006 | 11 | A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that show... | I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and m... | Inclusion Criteria:
1. Histologically confirmed adenocarcinoma of the stomach or gastro-oesophageal junction
with inoperable locally advanced or recurrent and/or metastatic disease not amenable
to curative therapy.
2. Measurable disease, according to the Response Evaluati... | Docetaxel, Oxaliplatin, Capecitabine, Bevacizumab and Trastuzumab in Patients With Locally Advanced or Metastatic Gastric Cancer | NCT01359397 | Entailment |
1,095 | 5 | A 23-year-old man comes to the emergency department following an episode of syncope. He was working out when he felt dizzy and passed out without head injury. He has had 3 other episodes of light-headedness over the last year, all happening during physical activity. He never had this experience while resting. He has ... | I'm 23, and I got admitted to the ER because I fainted all of a sudden. I was in the gym, working out, when all of a sudden, I just got dizzy and passed out. Hopefully, I didn't hit my head. It's not my first time having that kind of dizziness at the gym, never when I'm chilling at home tho. I don't have any special me... | Inclusion Criteria for participants with moderate-to-high anxiety to undergo drug
intervention:
- Willing and able to provide written, signed consent after the nature of the study has
been explained, and prior to any research-related procedures.
Age is > or = 18 and < or = 79 y... | Anxiety-mediated Impairments in Large Elastic Artery Function and the Autonomic Nervous System | NCT03109795 | Contradiction |
3,987 | 30 | A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 chi... | I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 year... | Inclusion Criteria:
- Male patients or female patients of non-childbearing potential Age between 40 to 75
years (both inclusive).
- Body weight > 40 kg, body mass index (BMI) < 40 kg/m2.
- Diagnosed for knee osteoarthritis based on clinical and radiological criteria of t... | A Study to Assess Efficacy and Safety of GLPG1972/S201086 in Patients With Knee Osteoarthritis | NCT03595618 | Entailment |
5,008 | 38 | A 60-year-old man comes to the clinic complaining of hand tremor that started few months ago. It is most bothering when he wants to drink from a glass or pour from a bottle. He does not smoke, but drinks occasionally. He recently started consuming more alcohol as his tremor subsides somewhat when he drinks small amoun... | I'm only a 60 years old man but I already suffer from shaky hands. It started a few months ago, and it really bothers me when I want to pour myself a glass or even while drinking. I don't smoke, but I drink alcohol from time to time. To be honest, I've been drinking a little more lately since it helps me with the shaki... | Inclusion Criteria:
- Parkinson´s disease patients according to UK Parkinson´s Disease Brain Bank Criteria
- Essential Tremor Patients according to Movement Disorder´s diagnosis consensus
criteria.
- Healthy Volunteers: paired with PD patients by age and gender.
... | Imaging in the Diagnosis of Parkinson's Disease and Essential Tremor | NCT01446939 | Entailment |
1,016 | 4 | A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes. The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief. Past medical history is notable for hypertension and hypercholesteremia. ... | I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tyl... | Inclusion Criteria:
1. Report of knee pain of at least 2/10 per NPRS (0---10 scale) for >3 months
2. Report of at least 3 of the following per Altman et al. (1986)
- Over 50 Years of age
- Less than 30 minutes of morning stiffness
- Crepitus on ac... | Dry Needling Versus Conventional Physical Therapy in Patients With Knee Osteoarthritis | NCT02373631 | Entailment |
556 | 2 | A 32-year-old woman comes to the hospital with vaginal spotting. Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with ... | I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing... | Inclusion Criteria:
- women with poor ovarian response candidate for ICSI
- women with spontaneous normal menstrual cycle
- normal uterine cavity
Exclusion Criteria:
- women with ovarian cysts
- endometriosis
- hydrosalpinx
- e... | Comparative Study Between Single Versus Dual Trigger for Poor Responders in GnRH-antagonist ICSI Cycles | NCT04008966 | Contradiction |
3,910 | 30 | A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 chi... | I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 year... | Inclusion Criteria:
1. Diagnosis of KOA;
2. Age 40-75 years;
3. KL (Kellgren-Lawrence) grade Ⅱ or Ⅲ in recent 3 months;
4. NRS score of pain at least more than 4 points;
5. Single/bilateral knee pain, duration of more than 6 month; If the patient has KOA on
... | Chinese Tuina Therapy for Treatment of Knee Osteoarthritis | NCT03966248 | Entailment |
4,599 | 35 | A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles. The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days. She is sexually active with her husband and... | I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of ... | Inclusion Criteria:
- General good health (by volunteer history and per investigator judgment) without any
clinically significant systemic disease (including, but not limited to significant
liver disease/hepatitis, gastrointestinal disease, kidney disease, thyroid disease,
... | Exploratory Pharmacodynamic Study of Tenofovir-Based Products | NCT02722343 | Entailment |
751 | 4 | A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes. The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief. Past medical history is notable for hypertension and hypercholesteremia. ... | I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tyl... | Inclusion Criteria:
To be considered eligible for enrollment into the study, subjects must;
- Be able to give written informed consent.
- Be female and between 18 and 65 years of age.
- Be a non-pregnant female.
- Be in generally good health as determined by the ... | A Study to Determine if Aquamin Modulates Inflammatory Biomarkers in the Blood of Osteoarthritis and Healthy Subjects | NCT01321281 | Contradiction |
2,347 | 15 | An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity m... | I brought my 8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weak... | Inclusion Criteria:
1. Duchenne muscular dystrophy resulting from a mutation correctable by treatment with
PRO045 confirmed by a state-of-the-art DNA diagnostic technique covering all DMD gene
exons, including but not limited to MLPA (Multiplex Ligation-dependent Probe
... | Phase IIb Study of PRO045 in Subjects With Duchenne Muscular Dystrophy | NCT01826474 | Entailment |
2,007 | 11 | A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that show... | I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and m... | Inclusion Criteria:
- Patients must have histologically or cytologically confirmed diagnosis of
adenocarcinoma of the stomach, gastroesophageal junction, or lower third of the
esophagus, AJCC stage II-IIIB (gastric) or IIA-IVA (esophageal). M1a disease will be
included... | Perioperative Panitumumab and Epirubicin, Oxaliplatin and Xeloda (EOX) in Patients With Gastroesophageal Adenocarcinoma | NCT00667420 | Entailment |
1,684 | 10 | A 19-year-old girl comes to the clinic due to a left wrist mass. She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns. Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient n... | I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penli... | Inclusion Criteria:
- Signed informed consent executed prior to protocol screening assessments;
- Men or women 18 to 65 years of age, inclusive (Women may be surgically sterile via
tubal ligation, bilateral oophorectomy or hysterectomy or who are postmenopausal for
>1 y... | PK Study Comparing Metformin Eicosapentaenoate to a Combined Dose of Metformin Hydrochloride and Ethyl Ester EPA | NCT02113163 | Entailment |
4,177 | 32 | A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia. The patient is sexually active with his wife and does not use any contraception methods. They have been trying to conceive for the past year with no success. The patient has a past medical history of recurrent p... | I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet ... | Inclusion Criteria:
- Subject must have the ability to understand and provide written informed consent
- Adult subjects 18 up to 50 years of age
- Subject must be willing and able to comply with study procedures and duration
- Subject is a non-smoker or who has not smoked... | Accuracy Assessment of Beddr Oximeter | NCT03710993 | Contradiction |
104 | 1 | A 19-year-old male came to clinic with some sexual concern. He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates. On physical examination, there is some pubic hair and poo... | I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me sm... | Inclusion Criteria:
- Female volunteers in early to mid-puberty (i.e., late Tanner I [estradiol level > 20
pg/mL], Tanner II, or Tanner III)
- Premenarcheal
Exclusion Criteria:
- Pregnancy
- Inability to comprehend what will be done during the study ... | Suppression of Daytime and Nighttime Luteinizing Hormone Frequency by Progesterone | NCT01428089 | Contradiction |
4,696 | 35 | A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles. The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days. She is sexually active with her husband and... | I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of ... | Inclusion Criteria:
- Non descent uterus with benign gynaecological conditions
Exclusion Criteria:
- Uterine size > 20 weeks
- Minilaparotomy was contraindicated in patients where severe adhesions might exist eg -
- Endometriosis
- Previous ... | Comparative Study of LAVH and Minilaparotomy Hysterectomy | NCT03548831 | Entailment |
1,053 | 5 | A 23-year-old man comes to the emergency department following an episode of syncope. He was working out when he felt dizzy and passed out without head injury. He has had 3 other episodes of light-headedness over the last year, all happening during physical activity. He never had this experience while resting. He has ... | I'm 23, and I got admitted to the ER because I fainted all of a sudden. I was in the gym, working out, when all of a sudden, I just got dizzy and passed out. Hopefully, I didn't hit my head. It's not my first time having that kind of dizziness at the gym, never when I'm chilling at home tho. I don't have any special me... | Inclusion Criteria:
- Overweight or obesity (BMI> 25 Kg/m2)
Exclusion Criteria:
- Any kind of drug
- Hypertension
- Endocrine diseases (diabetes mellitus, hypo or hyperthyroidism, hypopituitarism,
etc.),
- Chronic inflammatory diseases
... | Relationship Between Skeletal Muscle Mass and Interventricular Septum Thickness in Apparently Healthy Overweight and Obese Subjects | NCT04264091 | Contradiction |
2,959 | 21 | A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year. Over the last few months, he has also noticed weakness in the right upper extremity. BP is 120/75, PR is 80 and temperature is 37 C. Reflex... | I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rat... | Inclusion Criteria:
- Diagnosed with Amyotrophic lateral sclerosis (ALS)
Exclusion Criteria:
- Late stage ALS
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
| Muscle Training of Patients With Amyotrophic Lateral Sclerosis (ALS) | NCT01504009 | Entailment |
1,485 | 9 | A 67-year-old woman comes to the clinic due to recent episode of choking, dysphagia, and cough. Her other medical problems include hypertension, dyslipidemia, and osteoarthritis. She does not smoke or use alcohol. She lives with her husband and she is able to do her own daily activities. She used to teach elementary ... | I'm a 67-year-old lady, and I went to the clinic due to nonstop choking, difficulty swallowing, and coughing. I also suffer from hypertension, cholesterol, and osteoarthritis. I do not smoke or drink alcohol. I live with my husband, and we are independent retired elementary school teachers. During the exam, my blood pr... | Inclusion Criteria:
- Any patient with spontaneous or iatrogenic esophageal wall defect
Exclusion Criteria:
- None
No condition on gender to be admitted to the trial.
| Endoscopic Management of Esophageal Wall Defects | NCT04571541 | Entailment |
5,166 | 39 | A 55-year-old white woman comes for a routine checkup. She has no significant medical history and does not use tobacco, alcohol, or illicit drugs. The patient's only medication is an over-the-counter multivitamin. Family history is notable for a hip fracture in her mother. Blood pressure is 130/80 mm Hg and pulse i... | I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse w... | Inclusion Criteria:
- Person is a women with osteoporosis who is unwilling or unable to take other
treatments for osteoporosis
Exclusion Criteria:
- Person has had a previous fracture
- Person has rheumatoid arthritis. Person has has certain types of cancer
... | Proof of Concept (Bone Resorption/Bone Mineral Density) Study (0429-005) | NCT00533650 | Contradiction |
2,145 | 14 | A 39-year-old man comes to the emergency department with an acute onset of severe left toe pain. The toe is red and exhibits swelling. The patient is not febrile, and does not remember any recent trauma. Medical history is not significant except for the similar attacks and the diagnosis of gouty arthritis. His medicat... | I'm a 39-year-old man and got admitted to the ER after an unbearable pain in my left toe. My toe was red and terribly swollen. I was still standing on my feet, not febrile and I don't remember hitting my head or anything. I don't have any special medical history, but I had been diagnosed with gout before. I take Lopuri... | Inclusion Criteria:
1. Willing and able to give informed consent.
2. Willing and able to comply with the prescribed treatment protocol and evaluations for
the duration of the trial.
3. Adult men or women ≥18 and <80 years of age.
4. Uncontrolled gout, defined as ... | A Phase 4, Open-label Study of KRYSTEXXA® (Pegloticase) Co-administered With Methotrexate (MTX) in Patients With Uncontrolled Gout (FORWARD OL) | NCT04762498 | Contradiction |
2,334 | 15 | An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity m... | I brought my 8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weak... | INCLUSION CRITERIA
- Informed consent is obtained from the parent/ legal guardian
- The participant is aged between 2 months and 50 years
- The diagnosis of DMD is genetically confirmed by CENTOGENE
EXCLUSION CRITERIA
- Informed consent is not obtained from the p... | Biomarker for Duchenne Muscular Dystrophy | NCT02994030 | Entailment |
3,144 | 23 | A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn. The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness. She also reports occasional joint pain. Medical history... | I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to t... | Inclusion Criteria:
- Dry eye symptoms OSDI score 20 or higher
- Dryness, burning or foreign body sensation moderate or higher
Exclusion Criteria:
- Severe eye diseases
- Known allergy to any of the ingredients of the product
- Laser surgery of eyes d... | Effects of a Moisturizing Product on Dry Eye and Skin | NCT02683382 | Contradiction |
4,765 | 36 | A 47-year-old woman comes to the clinic complaining of dizziness. She also has occasional nausea and ringing in her right ear. The patient also has difficulty hearing while holding her phone to the left ear, although hearing in her right ear is normal. The dizziness improves spontaneously, and she feels fine between... | The other day, I had to go to the clinic due to severe dizziness. I'm 47 years old, and I've been suffering from nausea and ringing in my right ear. I also have difficulty hearing in my left ear while I hold my phone, even if my hearing in my right ear is normal. The dizziness just gets me all of a sudden but I don't h... | Inclusion Criteria:
1. Adults 40 years and older
2. English as primary language
3. Diagnosis of multisensory losses, presbystasis, bilateral vestibulopathy, central
vascular insufficiency, small vessel circulatory disease, generalized imbalance, and
idiopathic ... | Trental for the Treatment of Vertigo/Dizziness/Imbalance | NCT02592863 | Entailment |
4,884 | 37 | A 47-year-old man comes to the office due to weight gain and fatigue. He is not able to lift heavy objects or climb stairs. Family history is positive for DM type 2 and HTN in his father. Blood pressure is 165/90 mm Hg and pulse is 85/min. On physical examination, there is symmetric proximal muscle weakness of the u... | I'm a 47-year-old man. I went to the clinic because I had been gaining weight and had increased fatigue over the past few weeks. I was not able to lift heavy objects or even climb the stairs. My dad was diagnosed with type 2 diabetes and high blood pressure. During the exam, they took my blood pressure, which was 165/9... | INCLUSION CRITERIA:
SONICS STUDY COMPLETERS:
Completed the final SONICS visit (M12) and have demonstrated maintenance of clinical
response on a stable Therapeutic Dose of levoketoconazole for at least 12 weeks prior to
study entry.
ALL OTHERS:
- Confirmed newly dia... | A Study to Assess the Safety and Efficacy of Levoketoconazole in the Treatment of Endogenous Cushing's Syndrome. | NCT03277690 | Entailment |
1,173 | 6 | A 61-year-old man comes to the clinic due to nonproductive cough and progressive dyspnea. The patient's medical conditions include hypertension, hypercholesteremia and peptic ulcer disease. He smokes 2 packs of cigarettes daily for the past 30 years. On examination, there are decreased breath sounds and percussive d... | I am 61 and I had to go to the clinic because I couldn't stop coughing and I experienced some breath shortness. I suffer from hypertension and cholesterol and I also have a stomach ulcer. I should admit that I've been smoking 2 packs of cigarettes every day for the past 30 years. My doctor told me that my breath in my ... | Inclusion Criteria:
1. Referral to interventional pulmonary services for diagnostic transbronchial cryobiopsy
for diffuse parenchymal lung disease.
2. Transbronchial cryobiopsy is determined to be appropriately indicated as determined by
consulting interventional pulmonol... | CrYobiopsy With Radial UltraSound Guidance | NCT03506295 | Contradiction |
421 | 2 | A 32-year-old woman comes to the hospital with vaginal spotting. Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with ... | I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing... | Inclusion Criteria:
- 18 < age < 45 year old
- Thick irregular endometrium >12 mm on trans-vaginal ultrasound
Exclusion Criteria:
- Endometritis
- Cervical opening > 1 cm
- Uterine abnormalities
- Contraindication to Misoprostol treatment
... | Management of RPOC After Induced Abortion | NCT04685694 | Contradiction |
3,173 | 23 | A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn. The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness. She also reports occasional joint pain. Medical history... | I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to t... | Inclusion Criteria:
1. Diagnosis of primary Sjögren's Syndrome based on 2016 American College of
Rheumatology-EULAR criteria
2. ESSDAI total score ≥ 6 during screening, with at least 6 points scored within the 7
following domains: constitutional, lymphadenopathy, glandula... | Efficacy and Safety of S95011 in Primary Sjögren's Syndrome Patients | NCT04605978 | Entailment |
6,477 | 47 | A 41-year-old woman comes to the dermatology clinic complaining of facial redness, especially on her forehead and cheeks. She noticed that the redness gets worse in the summer and after sun exposure. She is otherwise healthy. On physical examination, she has multiple papules and pustules present on her forehead, cheeks... | I'm 41, married with 2 lovely kids who are 5 and 9 years old. I have an IUD and I don't want to have more kids. I don't smoke or drink alcohol. I had to go to the dermatology clinic because I had terrible redness on my face, especially on my forehead and cheeks. It got worse in the summer and after being under the sun.... | Inclusion Criteria:
Male and female 18 to 99 years of age. Chronic skin conditions (including but not limited
to atopic dermatitis, contact dermatitis, hidradenitis suppurativa, and psoriasis) with at
least one active skin lesion Healthy skin (defined no clinical evidence or diagnosis of
... | Linking Epidermal Barrier Function With Anti-Oxidant Defense Mechanisms in Skin Conditions | NCT03198390 | Entailment |
383 | 2 | A 32-year-old woman comes to the hospital with vaginal spotting. Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with ... | I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing... | Inclusion Criteria:
- Adult patients on the general wards in need of treatment by the MET team.
Exclusion Criteria:
- age (<18 years),
- pregnancy:
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18... | The Use of a Point-of-care Thoracic Ultrasound Protocol for Hospital Medical Emergency Teams | NCT03214809 | Contradiction |
6,822 | 48 | A 20-year-old man comes to the emergency due to bleeding after a tooth extraction. The bleeding has persisted for approximately 30 minutes despite constant direct pressure. He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family histo... | I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove... | Inclusion Criteria:
1. Be able to understand the purpose and risks of the study and provide signed and dated
informed consent and authorization to use protected health information (PHI) in
accordance with national and local privacy regulations;
2. Be male and ≥18 years of... | Gene Therapy for Chinese Hemophilia A | NCT04728841 | Entailment |
1,250 | 6 | A 61-year-old man comes to the clinic due to nonproductive cough and progressive dyspnea. The patient's medical conditions include hypertension, hypercholesteremia and peptic ulcer disease. He smokes 2 packs of cigarettes daily for the past 30 years. On examination, there are decreased breath sounds and percussive d... | I am 61 and I had to go to the clinic because I couldn't stop coughing and I experienced some breath shortness. I suffer from hypertension and cholesterol and I also have a stomach ulcer. I should admit that I've been smoking 2 packs of cigarettes every day for the past 30 years. My doctor told me that my breath in my ... | Inclusion Criteria:
- Patients with exudative pleural effusion
Exclusion Criteria:
- Patients without pleural effusion
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 20 Years old.
Subject must be at most 85 Ye... | Safety of Thoracoscopy in Patients With High Risk | NCT01193439 | Entailment |
1,069 | 5 | A 23-year-old man comes to the emergency department following an episode of syncope. He was working out when he felt dizzy and passed out without head injury. He has had 3 other episodes of light-headedness over the last year, all happening during physical activity. He never had this experience while resting. He has ... | I'm 23, and I got admitted to the ER because I fainted all of a sudden. I was in the gym, working out, when all of a sudden, I just got dizzy and passed out. Hopefully, I didn't hit my head. It's not my first time having that kind of dizziness at the gym, never when I'm chilling at home tho. I don't have any special me... | Inclusion Criteria:
- Age > = 16 yrs
- Acute syncope presentation to MAU or A+E
- 2 or more unexplained syncopes within the past 24 months including index episode
- Normal baseline ECG
- Absence of co - existing pathology requiring admission
Exclusion... | Eastbourne Syncope Assessment Study II | NCT00517023 | Contradiction |
4,894 | 38 | A 60-year-old man comes to the clinic complaining of hand tremor that started few months ago. It is most bothering when he wants to drink from a glass or pour from a bottle. He does not smoke, but drinks occasionally. He recently started consuming more alcohol as his tremor subsides somewhat when he drinks small amoun... | I'm only a 60 years old man but I already suffer from shaky hands. It started a few months ago, and it really bothers me when I want to pour myself a glass or even while drinking. I don't smoke, but I drink alcohol from time to time. To be honest, I've been drinking a little more lately since it helps me with the shaki... | Inclusion Criteria:
- Patients suffering from a head tremor without (isolated) or with associated
- tremor in any other body parts.
- The HT must be troublesome for the patients (TRS 2 for the head tremor
- severity item).
- Patients never treated with botulin... | Evaluation of Botulinum Toxin Injection Efficacy in the Treatment of Head Essential Tremor | NCT02555982 | Contradiction |
1,025 | 4 | A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes. The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief. Past medical history is notable for hypertension and hypercholesteremia. ... | I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tyl... | Inclusion Criteria:
- Men and women diagnosed with multiple arthritis (including CMC OA of the thumb) with
comorbidities (metabolic syndrome, i.e., OA and overweight / obesity, and/or
hyperglycemia, and/or dyslipidemia, and/or hyperuricemia, and/or hypertension).
- CMC ... | Saline Lavage X Saline Lavage and Osteonil® Mini in Rizarthritis | NCT03089723 | Entailment |
1,169 | 6 | A 61-year-old man comes to the clinic due to nonproductive cough and progressive dyspnea. The patient's medical conditions include hypertension, hypercholesteremia and peptic ulcer disease. He smokes 2 packs of cigarettes daily for the past 30 years. On examination, there are decreased breath sounds and percussive d... | I am 61 and I had to go to the clinic because I couldn't stop coughing and I experienced some breath shortness. I suffer from hypertension and cholesterol and I also have a stomach ulcer. I should admit that I've been smoking 2 packs of cigarettes every day for the past 30 years. My doctor told me that my breath in my ... | Inclusion Criteria:
- Patients scheduled for a CT-guided lung or upper abdomen biopsy (including lesions in
the liver, pancreas, stomach, kidneys, adrenals, spleen, or in the peritoneum at or
above the level of the kidneys) on the SMH-CT-3M scanner when either Dr. Carlson or
... | Optical Breath-hold Control System for Image-guided Procedures | NCT01062789 | Contradiction |
6,245 | 46 | The patient is a 38-year-old man with cough and body ache that started 3 days ago. He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within n... | I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my tem... | Inclusion Criteria:
- Positive COVID-19
Exclusion Criteria:
- Incomplete medical records, degrade CT images because of patient tachypnea and motions
artifacts, also unremarkable CT scans.
No condition on gender to be admitted to the trial.
| Egyptian Initial Experience About 2019 Novel Corona Virus: Study of 48 Patients in Alexandria-Egypt Using Chest CT | NCT04382469 | Contradiction |
3,301 | 24 | A 4-year-old boy comes to the office for the follow up of his confirmed oculocutaneous albinism. The patient was born at 38 weeks gestation with no complications. Vital signs are normal. Weight and height are at the 50th percentile. On examination, iris transillumination is present, and there are no apparent foveae... | I brought my four-year-old son to his follow-up consultation for his albinism. All his hair is white, even lashes and eyebrows. My baby was born at 38 weeks pregnant with no complications whatsoever. During the consultations his vitals were normal and now his weight and height are at the 50th percentile. The doctor did... | Inclusion Criteria:
- Minor and adult patient.
- Patient presenting a clinical diagnosis of incomplete form of albinism with presence
of at least 2 signs of ocular albinism among which nystagmus, low vision, foveal
hypoplasia, retinal hypopigmentation, translucent iride... | NGS Panel of Incomplete Forms of Ocular Albinism | NCT04495218 | Contradiction |
2,595 | 20 | A 49-year-old man comes to the office because of the bulging in his groin. Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases. His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications... | I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to... | Inclusion Criteria:
1. Men or women ≥ 18 years of age and able to give their own consent.
2. The subject is able and willing to comply with study procedures and a signed and dated
informed consent is obtained.
3. The subject has a complex ventral hernia
4. The su... | A Prospective Case Series Evaluating Surgimend Mp® In Patients Undergoing Complex Abdominal Hernia Repair | NCT03450473 | Contradiction |
6,233 | 46 | The patient is a 38-year-old man with cough and body ache that started 3 days ago. He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within n... | I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my tem... | Inclusion Criteria:
- COVID 19 confirmed patients.
Exclusion Criteria:
- <18 years
- Pregnant women
- Asymptomatic and normal x-ray findings subjects
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must ... | Predicting Death and ICU Admission in COVID-19 Patients in ED | NCT04371562 | Contradiction |
1,770 | 11 | A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that show... | I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and m... | Inclusion Criteria:
- Age of 18 ~ 75, with a elementary-school diploma or higher, should be able to read and
write Korean
- One who meet Rome III FD criteria* and has been suffering from FD for the last 3
months with symptom onset at least 6 months prior to diagnosis
... | Effect of Acupuncture on Patients With Functional Dyspepsia: a Multi-center, Randomized, Waitlist-controlled Trial | NCT01921504 | Contradiction |
4,141 | 32 | A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia. The patient is sexually active with his wife and does not use any contraception methods. They have been trying to conceive for the past year with no success. The patient has a past medical history of recurrent p... | I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet ... | Inclusion Criteria:
- according to the consensus of domestic experts, combined with the guidelines for the
management of adult bronchiectasis published by the European Respiratory Society in
2017;
- male or female, aged 18-70 years;
- being in the stable sta... | A Series of N-of-1 Trials of Traditional Chinese Medicine Based on Bayesian Method | NCT04601792 | Contradiction |
1,150 | 5 | A 23-year-old man comes to the emergency department following an episode of syncope. He was working out when he felt dizzy and passed out without head injury. He has had 3 other episodes of light-headedness over the last year, all happening during physical activity. He never had this experience while resting. He has ... | I'm 23, and I got admitted to the ER because I fainted all of a sudden. I was in the gym, working out, when all of a sudden, I just got dizzy and passed out. Hopefully, I didn't hit my head. It's not my first time having that kind of dizziness at the gym, never when I'm chilling at home tho. I don't have any special me... | Inclusion Criteria:
- Male and female patients aged 18 - 80 years old
- Diagnosed HCM defined by the presence of unexplained left-ventricular hypertrophy with
end-diastolic wall thickness ≥ 15 mm on 2D echocardiography or wall thickness between
13 and 15 mm along with a... | High Intensity Exercise for Increasing Fitness in Patients With Hypertrophic Cardiomyopathy | NCT03335332 | Entailment |
3,012 | 22 | A 15-year-old boy with mild intellectual disability is brought to the office by his parents for a routine physical examination. The boy is going to a school for students with learning disabilities. The patient was adopted, and his immunizations are up to date. Review of the patient's medical records is notable for c... | My husband and I brought our 15-year-old son to the clinic for his routine exam. My son is going to school for special needs students. We adopted him a few years ago. His vaccinations are up to date. He already passed some chromosome testing and they found that he has a fragile X syndrome. The doctor told us that it co... | Inclusion Criteria:
- Molecular diagnosis of Fragile X syndrome (FXS)
- Males and females aged 12 to 60 years.
- Study participants must understand and accept experimental procedures and assent to
participate in the study signing an informed consent.
- Parent... | "Using Epigallocatechin Gallate (EGCG) and Cognitive Training to Modulate Cognitive Performance in Patients With Fragile X Syndrome" (TESFX) | NCT01855971 | Contradiction |
6,875 | 50 | A 70-year-old man comes to the office accompanied by his wife. The patient has experienced progressive memory loss over the last years. He needs help with some of his routine activities, such as paying bills. The patient's wife says, "He used to be such an independent person, but now he needs help with many things, ... | I am a 70-year-old man, and I paid a visit to the doctor with my wife the other day. I noticed that I tend to forget small things and that my memory has decreased over the past few years. I even ask my wife to help me out with my daily routine. I used to be the one paying the bills, but now she has to give me a hand. M... | Inclusion Criteria:
- 1. Men and women aged 55-85 years
- 2. Diagnosis of possible or probable Alzheimer disease according to NIA-AA 2011
criteria.
- 3. Global Deterioration Scale Stadium 5-6 / 15-5 Mini-mental State examination
- 4. The patient is living wit... | ATP in Alzheimer Disease | NCT02279511 | Contradiction |
1,805 | 11 | A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that show... | I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and m... | Inclusion Criteria:
Primary registration
- Person having intact stomach after treatment of early gastric cancer or gastric
adenoma
- Person whose treated gastric cancer histological type is intestinal type.
- Person whose treated gastric cancer or gastric adenom... | Reversal of Preneoplastic Metaplasia in the Stomach With MEK Inhibitor | NCT04454476 | Contradiction |
2,932 | 21 | A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year. Over the last few months, he has also noticed weakness in the right upper extremity. BP is 120/75, PR is 80 and temperature is 37 C. Reflex... | I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rat... | Inclusion Criteria:
- Caucasian male or female out-patients;
- aged 18 to 75 years inclusive;
- diagnosis of "probable" or "definite" amyotrophic lateral sclerosis according to the
El Escorial revised criteria (1);
- first symptoms of ALS by no more than 1.5 ... | Efficacy and Tolerability of Tauroursodeoxycholic Acid in Amyotrophic Lateral Sclerosis | NCT00877604 | Entailment |
6,881 | 50 | A 70-year-old man comes to the office accompanied by his wife. The patient has experienced progressive memory loss over the last years. He needs help with some of his routine activities, such as paying bills. The patient's wife says, "He used to be such an independent person, but now he needs help with many things, ... | I am a 70-year-old man, and I paid a visit to the doctor with my wife the other day. I noticed that I tend to forget small things and that my memory has decreased over the past few years. I even ask my wife to help me out with my daily routine. I used to be the one paying the bills, but now she has to give me a hand. M... | Inclusion Criteria:
- Fluent in English or Spanish
- Diagnosis of aMCI by Petersen criteria or probable AD by National Institute of
Neurological and Communicative Diseases and Stroke/Alzheimer's Disease and Related
Disorders Association (NINCDS-ADRDA) criteria
... | The Study of Nasal Insulin in the Fight Against Forgetfulness (SNIFF) | NCT01767909 | Contradiction |
4,040 | 30 | A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 chi... | I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 year... | Inclusion Criteria:
- Men and women diagnosed with primary osteoarthritis of the knee,
- Classified as stages I to III of Kelgreen and Lawrence (KL), ie any degree of
gonarthritis without obliteration of the joint space.
- With indication for clinical treatment of OA.
... | Project Arthritis Recovering Quality of Life by Means Education II (PARQVE II) | NCT02335034 | Entailment |
3,388 | 25 | A 50-year-old woman comes to the clinic with intermittent ear discharge and sense of hearing loss on her left ear. Past medical history is significant for obesity, hyperlipidemia, and diabetes mellitus. Her medications include Metformin, Atorvastatin and Vit D supplement. Vital signs are normal. BMI is 37. Otoscopy s... | I went to the clinic the other day because I had some fluid in my ear and I felt like I could not hear as well as I used to in my left ear. I'm a 50-year-old woman, and I have been obese for a while now. I have diabetes and cholesterol. I take some medication. I take metformin, atorvastatin, and vitamin D supplements. ... | Inclusion Criteria:
- Bilateral hearing loss equal or higher than 40 decibels
- Age 65 years old or more
- Agree to be included in the study
- Have a relative to go to the intervention with the subject
Exclusion Criteria:
- Severe organic brain impair... | Assessment of the ACE Program for Rehabilitation in Hearing Loss | NCT01846676 | Contradiction |
1,101 | 5 | A 23-year-old man comes to the emergency department following an episode of syncope. He was working out when he felt dizzy and passed out without head injury. He has had 3 other episodes of light-headedness over the last year, all happening during physical activity. He never had this experience while resting. He has ... | I'm 23, and I got admitted to the ER because I fainted all of a sudden. I was in the gym, working out, when all of a sudden, I just got dizzy and passed out. Hopefully, I didn't hit my head. It's not my first time having that kind of dizziness at the gym, never when I'm chilling at home tho. I don't have any special me... | Inclusion Criteria:
- Patient is 18 years and older has a clinical diagnosis of hypertrophic cardiomyopathy.
- Patient scheduled for clinically-indicated myomectomy.
- Patient has a negative family history of hypertrophic cardiomyopathy
- Patient is willing to receive res... | Genomic Sequencing in Patients With HCM Undergoing Septal Myectomy | NCT03043209 | Entailment |
397 | 2 | A 32-year-old woman comes to the hospital with vaginal spotting. Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with ... | I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing... | Inclusion Criteria:
- Ability to understand and provide a written informed consent.
- Healthy adult females between 18 and 50 years of age. Included in this group are women
with the following conditions, not currently receiving drug treatment:
- Excessive menstrual ... | Determination of the Lowest, Safe and Effective Dose of Proellex | NCT01187043 | Contradiction |
4,811 | 36 | A 47-year-old woman comes to the clinic complaining of dizziness. She also has occasional nausea and ringing in her right ear. The patient also has difficulty hearing while holding her phone to the left ear, although hearing in her right ear is normal. The dizziness improves spontaneously, and she feels fine between... | The other day, I had to go to the clinic due to severe dizziness. I'm 47 years old, and I've been suffering from nausea and ringing in my right ear. I also have difficulty hearing in my left ear while I hold my phone, even if my hearing in my right ear is normal. The dizziness just gets me all of a sudden but I don't h... | Inclusion Criteria:
- Male or female patients 18 years of age and older
- Patients with vestibular vertigo of known or unknown origin
- Patients who are willing and able to provide written informed consent
Exclusion Criteria:
- Patients with any condition which, ... | To Study the Characteristics of Different Types of Vertigo in Patients Attending the Ear Nose & Throat (ENT) Clinics. | NCT02213120 | Entailment |
5,416 | 40 | A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction. Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration. The patient has heavy menstrual cycles each month. She has no other medical problems and takes no medications... | I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical c... | Inclusion Criteria:
- Women 18 years or older in generally good health with a diagnosis of heavy menstrual
bleeding without organic pathology, requesting contraception
- Willingness to use barrier contraception (e.g., condoms) from screening to study
completion
... | Study of a 4-phasic Oral Contraceptive for the Treatment of Heavy Menstrual Bleeding | NCT01638923 | Entailment |
5,927 | 44 | A 48-year-old man comes to the office complaining of heartburn and acid reflux. He has taken over-the-counter antacids but sees no relief. Other medical history is unremarkable. The patient does not use tobacco, alcohol, or illicit drugs. Vital signs are within normal limits. BMI is 31 kg/m2. Physical examination... | I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old gu... | Inclusion Criteria:
- Pregnant women gestational age less than 36 weeks with heartburn
Exclusion Criteria:
- Having medical disease that contraindicated to use study drug
- Allergic to alginate-based reflux suppressant and magnesium-aluminium antacid gel
Female
Accepts Healt... | Alginate-based Reflux Suppressant and Magnesium-aluminium Antacid Gel for Treatment of Heartburn in Pregnancy | NCT02470117 | Contradiction |
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