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1,455 | 9 | A 67-year-old woman comes to the clinic due to recent episode of choking, dysphagia, and cough. Her other medical problems include hypertension, dyslipidemia, and osteoarthritis. She does not smoke or use alcohol. She lives with her husband and she is able to do her own daily activities. She used to teach elementary ... | I'm a 67-year-old lady, and I went to the clinic due to nonstop choking, difficulty swallowing, and coughing. I also suffer from hypertension, cholesterol, and osteoarthritis. I do not smoke or drink alcohol. I live with my husband, and we are independent retired elementary school teachers. During the exam, my blood pr... | Inclusion Criteria:
- Normal Volunteers:
- Older than 55 years of age
- No history of voice, swallowing, reflux, or progressive neurologic disease
affecting the swallowing mechanism.
- A normal self-administered dysphagia questionnaire (EA... | The Effect of Food Taste, Temperature, and Viscosity on Swallowing Efficiency | NCT01270204 | Entailment |
1,919 | 11 | A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that show... | I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and m... | Inclusion Criteria:
1. Signed and dated informed consent;
2. Pathologically confirmed advanced gastric adenocarcinoma (including Gastroesophageal
junction adenocarcinoma) with measurable lesions outside stomach (RECIST 1.1)
3. Advanced stomach cancer patients who have faile... | Study of Anlotinib in Patients With Gastric Cancer(ALTER0503) | NCT02461407 | Entailment |
3,370 | 25 | A 50-year-old woman comes to the clinic with intermittent ear discharge and sense of hearing loss on her left ear. Past medical history is significant for obesity, hyperlipidemia, and diabetes mellitus. Her medications include Metformin, Atorvastatin and Vit D supplement. Vital signs are normal. BMI is 37. Otoscopy s... | I went to the clinic the other day because I had some fluid in my ear and I felt like I could not hear as well as I used to in my left ear. I'm a 50-year-old woman, and I have been obese for a while now. I have diabetes and cholesterol. I take some medication. I take metformin, atorvastatin, and vitamin D supplements. ... | Inclusion Criteria:
- Patients diagnosed with Sudden Sensorineural Hearing Loss, treated using
intra-tympanic injection of steroids to the middle ear
Exclusion Criteria:
- Patients with abnormal sense of taste
- Middle or inner ear anomaly
- Eustachi... | The Effect of Patient's Position After Intra-tympanic Injection on the Amount of Fluid in the Middle Ear | NCT04449848 | Contradiction |
4,777 | 36 | A 47-year-old woman comes to the clinic complaining of dizziness. She also has occasional nausea and ringing in her right ear. The patient also has difficulty hearing while holding her phone to the left ear, although hearing in her right ear is normal. The dizziness improves spontaneously, and she feels fine between... | The other day, I had to go to the clinic due to severe dizziness. I'm 47 years old, and I've been suffering from nausea and ringing in my right ear. I also have difficulty hearing in my left ear while I hold my phone, even if my hearing in my right ear is normal. The dizziness just gets me all of a sudden but I don't h... | Inclusion criteria:
Adult (18 years and older) ED patients with all of the following (all determined
pre-randomization):
VESTIBULAR SYMPTOMS: presenting symptom of "vertigo" OR "dizziness" OR "unsteadiness" (as
defined by consensus expert definitions in the International Classification... | Acute Video-oculography for Vertigo in Emergency Rooms for Rapid Triage (AVERT) | NCT02483429 | Entailment |
267 | 2 | A 32-year-old woman comes to the hospital with vaginal spotting. Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with ... | I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing... | Inclusion Criteria:
- Age 18-49 years
- General good health
- Does not want to be pregnant
- History of regular monthly menstrual cycles (±3 days)
- Missed menses of 1 to 10 days as verified by report of last menstrual period
- Sexual activity in t... | Assessing Use Of Mifepristone After Progestin Priming For Use As "Missed Period Pills" | NCT04676776 | Contradiction |
2,252 | 14 | A 39-year-old man comes to the emergency department with an acute onset of severe left toe pain. The toe is red and exhibits swelling. The patient is not febrile, and does not remember any recent trauma. Medical history is not significant except for the similar attacks and the diagnosis of gouty arthritis. His medicat... | I'm a 39-year-old man and got admitted to the ER after an unbearable pain in my left toe. My toe was red and terribly swollen. I was still standing on my feet, not febrile and I don't remember hitting my head or anything. I don't have any special medical history, but I had been diagnosed with gout before. I take Lopuri... | Inclusion Criteria:
- People with gouty arthritis in the knee or ankle or metatarsophalangeal or
metacarpophalangeal or olecranon bursa or wrist
- Participants were Indonesian nationals aged ≥18 years
- They had visited a clinic of the Public CHS of Tomohon City
... | The Relationship Between Cold Water Immersion and the Progression in Gout Arthritis | NCT04587544 | Entailment |
2,601 | 20 | A 49-year-old man comes to the office because of the bulging in his groin. Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases. His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications... | I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to... | Inclusion Criteria:
- Adult patients
- Underwent uni-or bilateral groin hernia repair in the period March 2015 - March 2020
- Groin hernia repair via robotic assisted laparoscopy or open surgery
- History of abdominal prostatectomy before the groin hernia repair
... | Repair of Groin Hernias After Abdominal Prostatectomy With Robotic TAPP | NCT04718597 | Contradiction |
3,500 | 26 | A 33-year-old woman comes to clinic complaining of progressive fatigue, decreased appetite, and 11-lb weight loss in the past 2 months. She uses levothyroxine because of the previously diagnosed Hashimoto disease. She has no other medical conditions and does not use tobacco, alcohol, or illicit drugs. Physical examin... | I went to the clinic because I was really suffering from fatigue and decreased appetite and I also lost 11 pounds over the past two months. I'm just 33 years old so that's not normal, especially for a woman. I take levothyroxine because I have been diagnosed with Hashimoto disease. I don't have any other medical condit... | Inclusion Criteria:
- Age ≥18 years
- Documented chronic adrenal insufficiency
- Established corticosteroid replacement therapy
- Written informed consent
Exclusion Criteria:
- Age <18 years
No condition on gender to be admitted to the trial.
Subject mu... | Management of Adrenal Emergency in Germany | NCT03426332 | Contradiction |
2,382 | 15 | An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity m... | I brought my 8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weak... | - ELIGIBILITY CRITERIA:
This study will include healthy males and females who are over four years of age. The study
will involve healthy volunteers having normal lower extremity strength profiles and healthy
volunteers with impaired ankle joint plantarflexion strength. For this project, the te... | Gait Adaptations to Passive Dynamic Ankle-Foot Orthosis Use | NCT00115401 | Entailment |
679 | 3 | A 51-year-old man comes to the office complaining of fatigue and some sexual problems including lack of libido. The patient doesn't smoke or use any illicit drug. Blood pressure is 120/80 mm Hg and pulse is 70/min. Oxygen saturation is 99% on room air. BMI is 24 kg/m2. Skin examination shows increased pigmentation.... | I am 51 years old and I just came back from the doctor's office. I'm sick and tired of being that exhausted, reaching the point where me and my lovely wife are not touching each other anymore! I'm not smoking or doing drugs! My blood pressure was 120/80 mm Hg, and pulse was 70/min and my oxygen saturation 99%. My BMI i... | Inclusion Criteria:
- Men and women aged 18 and older
- Confirmed diagnosis of HFE-related hereditary hemochromatosis with prior genotype
testing
- Documented stable phlebotomy for ≥ 6 months
- Screening hemoglobin >11.5 g/dL
- Documented evidence... | PTG-300 in Subjects With Hereditary Hemochromatosis | NCT04202965 | Entailment |
6,733 | 48 | A 20-year-old man comes to the emergency due to bleeding after a tooth extraction. The bleeding has persisted for approximately 30 minutes despite constant direct pressure. He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family histo... | I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove... | Key Inclusion Criteria:
- Have severe hemophilia A, defined as <1 IU/dL (<1%) endogenous FVIII as determined by
one-stage clotting assay from the central laboratory at Screening.
- Previously treated subject, defined as having at least 150 documented prior exposure
days... | Pharmacokinetics and Safety of rFVIIIFc Manufactured at 15,000 L (15K) Scale | NCT02502149 | Contradiction |
4,229 | 32 | A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia. The patient is sexually active with his wife and does not use any contraception methods. They have been trying to conceive for the past year with no success. The patient has a past medical history of recurrent p... | I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet ... | Inclusion Criteria:
-Male patients diagnosed with azoospermia and severe oligozoospermia.
Exclusion Criteria:
1. Klinefelter Syndrome ;
2. Structural chromosome aberrations；
3. Obstructive anspermia;
4. Male infertility caused by endocrine factors;
... | Detection of Microdeletions in the Azoospermia Factor (AZF) Regions in Infertile Male Patients | NCT03497728 | Contradiction |
6,996 | 50 | A 70-year-old man comes to the office accompanied by his wife. The patient has experienced progressive memory loss over the last years. He needs help with some of his routine activities, such as paying bills. The patient's wife says, "He used to be such an independent person, but now he needs help with many things, ... | I am a 70-year-old man, and I paid a visit to the doctor with my wife the other day. I noticed that I tend to forget small things and that my memory has decreased over the past few years. I even ask my wife to help me out with my daily routine. I used to be the one paying the bills, but now she has to give me a hand. M... | Participants will be classified as either Alzheimer's disease(AD) group, mild cognitive
impairment(MCI) group, elderly normal controls or young normal controls. Specific inclusion
criteria for each group is described below.
[Inclusion criteria: AD]
- Age : 55 - 90
- Clin... | Korean Brain Aging Study for Early Diagnosis and Prediction of Alzheimer's Disease | NCT02137460 | Entailment |
6,913 | 50 | A 70-year-old man comes to the office accompanied by his wife. The patient has experienced progressive memory loss over the last years. He needs help with some of his routine activities, such as paying bills. The patient's wife says, "He used to be such an independent person, but now he needs help with many things, ... | I am a 70-year-old man, and I paid a visit to the doctor with my wife the other day. I noticed that I tend to forget small things and that my memory has decreased over the past few years. I even ask my wife to help me out with my daily routine. I used to be the one paying the bills, but now she has to give me a hand. M... | Inclusion Criteria:
- Alzheimers disease according to (National Institute of Neurological and Communicative
Disorders and Stroke and the Alzheimer's Disease and Related Disorders Association).
- The cognitive impairment and decline must be documented by cognitive /
neur... | Transcranial Direct Current Stimulation (tDCS) as a Cognitive Enhancer for Patients With Alzheimers Disease | NCT02518412 | Entailment |
3,114 | 23 | A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn. The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness. She also reports occasional joint pain. Medical history... | I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to t... | General inclusion criteria for all subjects will include:
- Ages 50 to 89 years
- Capacity to give informed consent.
- Self-reported literacy (i.e. a "Yes" answer to the question "Have you learned how to
read?")
Additional inclusion criteria for the dry eye grou... | Effects of Sustained Reading on the Ocular Surface | NCT02031172 | Contradiction |
6,909 | 50 | A 70-year-old man comes to the office accompanied by his wife. The patient has experienced progressive memory loss over the last years. He needs help with some of his routine activities, such as paying bills. The patient's wife says, "He used to be such an independent person, but now he needs help with many things, ... | I am a 70-year-old man, and I paid a visit to the doctor with my wife the other day. I noticed that I tend to forget small things and that my memory has decreased over the past few years. I even ask my wife to help me out with my daily routine. I used to be the one paying the bills, but now she has to give me a hand. M... | Patient's inclusion criteria:
- Aged 65 and over
- AD or mixed dementia (DSM IV TR criteria), documented by a neuropsychological
assessment and a brain imaging
- Living at home
- Having a caregiver (more than 2 visits per week)
- Agreement for the... | Alzheimer Disease : Rehabilitation's Intervention at Home | NCT01689948 | Entailment |
4,511 | 35 | A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles. The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days. She is sexually active with her husband and... | I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of ... | Inclusion Criteria:
- Women with regular menses
- Adenomyosis diagnosed via transvaginal ultrasound
- With severe dysmenorrhea (VAS ≥ 7) and/or menorrhea (pictorial chart scores >100)
- Duration of placement > 12 months
- Size of uterus by physical examination... | Levonorgestrel-releasing Intrauterine System for the Treatment of Symptomatic Adenomyosis | NCT03027648 | Contradiction |
1,168 | 6 | A 61-year-old man comes to the clinic due to nonproductive cough and progressive dyspnea. The patient's medical conditions include hypertension, hypercholesteremia and peptic ulcer disease. He smokes 2 packs of cigarettes daily for the past 30 years. On examination, there are decreased breath sounds and percussive d... | I am 61 and I had to go to the clinic because I couldn't stop coughing and I experienced some breath shortness. I suffer from hypertension and cholesterol and I also have a stomach ulcer. I should admit that I've been smoking 2 packs of cigarettes every day for the past 30 years. My doctor told me that my breath in my ... | Inclusion Criteria:
- 1. Unilateral moderate or massive exudative pleural effusion patients. 2. Undiagnosed
pleural effusion after simple pleural fluid aspiration, cytology or blind (closed) pleural
biopsy using Abram's needle.
3. Age>18 years old
Exclusion Criteria:
... | Role of Cryobiopsy in Diagnosis of Pleural Effusion | NCT03828903 | Contradiction |
6,577 | 48 | A 20-year-old man comes to the emergency due to bleeding after a tooth extraction. The bleeding has persisted for approximately 30 minutes despite constant direct pressure. He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family histo... | I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove... | Inclusion Criteria:
- Complete physical and mental health, with no confounding history of systemic disease
and/or use of special local or systemic drugs
- No allergic reactions recorded in patient history
- Having primary molar teeth in one jaw, having deep caries and vi... | Clinical and Radiographic Evaluation in Pulpotomy of Primary Molars Using Protooth Vs. MTA | NCT04710160 | Contradiction |
3,117 | 23 | A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn. The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness. She also reports occasional joint pain. Medical history... | I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to t... | Inclusion Criteria:
- Nulliparous and primiparous
Exclusion Criteria:
- in G1 (nulliparous) were UI, neurological diseases, previous pelvic surgeries,
diabetes, smoking and cognitive difficulties. In G2 (primiparas), the same criteria
were used including women wit... | Pelvic Floor Muscle Function in Nulliparous and Primiparous. | NCT01315769 | Contradiction |
739 | 4 | A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes. The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief. Past medical history is notable for hypertension and hypercholesteremia. ... | I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tyl... | Inclusion Criteria:
- Individuals diagnosed with knee osteoarthritis II-III level according to the results
of radiological evaluation by Kellgren and Lawrence
- Individuals aged between 40 and 65 years
- Individuals who have pain in his/her either of the knees in 3 month... | The Validity, Reliability and Responsiveness of the Fullerton Advanced Balance Scale in Osteoarthritis | NCT03728387 | Contradiction |
2,577 | 20 | A 49-year-old man comes to the office because of the bulging in his groin. Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases. His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications... | I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to... | Inclusion Criteria:
- Groin pain (unilateral or bilateral) for at least 4 months. In this way, patients with
temporary symptoms will be excluded from undergoing unnecessary surgery.
- Tenderness over pubic tubercle or superficial inguinal ring.
Exclusion Criteria:
... | A Randomised, Blinded Study on Laparoscopic Mesh Reinforcement for Chronic Groin Pain | NCT00934388 | Contradiction |
2,037 | 11 | A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that show... | I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and m... | Inclusion Criteria:
- gastric cancer
Exclusion Criteria:
- for group III constituted gastric cancer associated with severe gastrointestinal
obstruction
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at lea... | Perioperative Immunonutrition, Phagocytic and Bactericidal Activity of Blood Platelets in Gastric Cancer Patients | NCT01704664 | Entailment |
476 | 2 | A 32-year-old woman comes to the hospital with vaginal spotting. Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with ... | I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing... | Inclusion Criteria:
1. women of childbearing age from 20 to 50 years old
2. with or without menstrual changes:
1. menostaxis (longer than 7 days)
2. shortened menstrual cycles(less than 23 days)
3. menorrhagia(more than twice as much as usual)
... | Dydrogesterone in the Treatment of Endometrial Polyps | NCT03790215 | Contradiction |
1,666 | 10 | A 19-year-old girl comes to the clinic due to a left wrist mass. She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns. Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient n... | I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penli... | Inclusion Criteria:
1. Provided written informed consent to participating in the trial.
2. Caucasian, female or male, and aged 18 years to 55 years, inclusive.
3. Body mass index between 18.5 kg/m2 and 30 kg/m2, inclusive, with a lower body weight
limit of 50 kg.
... | Evaluation of the Antihyperalgesic Effect of Tapentadol in Two Human Experimental Models | NCT01615510 | Entailment |
5,147 | 39 | A 55-year-old white woman comes for a routine checkup. She has no significant medical history and does not use tobacco, alcohol, or illicit drugs. The patient's only medication is an over-the-counter multivitamin. Family history is notable for a hip fracture in her mother. Blood pressure is 130/80 mm Hg and pulse i... | I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse w... | Inclusion Criteria:
- Diagnosis of severe osteoporosis
- Non-response to anti-osteoporotic treatment for over 2 years
- Normal hematology function
- Ability to provide a written, dated, and signed informed consent prior to any study
related procedure, and to ... | Phase 2a Study on Intravenous Infusion of Autologous Osteoblastic Cells in Severe Osteoporosis | NCT02061995 | Contradiction |
2,439 | 16 | A 39-year-old woman comes to the clinic complaining of arthralgias and nodules on her legs. She has no fever or other skin rashes. The prior medical condition is unremarkable, and she takes no medications. On physical examination, there is moderate hepatomegaly. The lesions on her legs are tender and present predomin... | I'm just a 39-year-old young woman but lately I have noticed some underlying cysts on my legs and my joints were hurting so much. I don't have a fever. I don't have rashes. My medical history is totally clean and I don't take any medication. When I went to the clinic they did a physical examination where they found tha... | Inclusion Criteria:
1. Males or females, of any race, between 18 and 85 years of age, inclusive
2. Able to provide written informed consent
3. Clinician diagnosis of sarcoidosis
4. Treatment-naïve or receiving immunomodulatory therapy.
Exclusion Criteria:
1.... | Exploring the Immunology of Sarcoidosis | NCT04637165 | Entailment |
22 | 1 | A 19-year-old male came to clinic with some sexual concern. He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates. On physical examination, there is some pubic hair and poo... | I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me sm... | Inclusion Criteria:
- Cancer survivors who have received chemotherapy and/or radiation therapy for their
cancer and are now in remission for at least one year
- Non-hormone-dependent cancer, including most solid tumors, lymphomas and leukemias
- Age: 18-50 years
... | Improving Patient-Important Outcomes With Testosterone Replacement in Hypogonadal Men With a Prior History of Cancer | NCT04049331 | Contradiction |
5,397 | 40 | A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction. Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration. The patient has heavy menstrual cycles each month. She has no other medical problems and takes no medications... | I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical c... | Inclusion Criteria:
- Male or female patients;
- ≥ 16 to ≤ 75 years of age;
- Diagnosis of VWD-2B according to national expert guidelines for the USA [1] and Europe
[2] based on medical history and findings from a matrix of laboratory assays which may
includ... | A Study of the Pharmacokinetics, Pharmacodynamics, and Safety of ARC1779 Injection in Patients With Von Willebrand Disease Type 2B | NCT00694785 | Entailment |
5,960 | 44 | A 48-year-old man comes to the office complaining of heartburn and acid reflux. He has taken over-the-counter antacids but sees no relief. Other medical history is unremarkable. The patient does not use tobacco, alcohol, or illicit drugs. Vital signs are within normal limits. BMI is 31 kg/m2. Physical examination... | I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old gu... | Inclusion Criteria:
- Laparoscopic sleeve gastrectomy (LSG) for obesity >12 months prior to proposed device
implantation date.
- Patient is a surgical candidate, i.e. is able to undergo general anesthesia and
laparoscopic surgery.
- Documented pathologic eso... | RELIEF Europe Study | NCT02762487 | Contradiction |
520 | 2 | A 32-year-old woman comes to the hospital with vaginal spotting. Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with ... | I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing... | Inclusion Criteria:
- • Inclusion criteria of study group (1&2):
1. Women with primary or secondary infertility for more than 1 year due to
unexplained infertility (normal regular menstrual cycles and normal pelvic
examination, evidence of ovulation by TV/... | Assessment of Endometrial Thickness & Subendometrial Perfusion by 3D Power Doppler in Women With Unexplained Infertility and PCOS. | NCT03397693 | Contradiction |
3,118 | 23 | A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn. The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness. She also reports occasional joint pain. Medical history... | I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to t... | Inclusion criteria:
- Age ≥ 18 years
- Normal ophthalmic findings except dry eye disease
- Ametropy ≤ 6 diopters
- Chronic dry eye defined as longer than six months since diagnosis
- OSDI ≥ 22
- Conjunctival Hyperemia ≥ Grade 3 (Efron Scale)
... | Clinical Efficacy of Topical Hydrocortisone 0.335% (Softacort®) in Patients With Chronic Dry Eye Disease and Associated Ocular Surface Inflammation | NCT03907865 | Contradiction |
6,774 | 48 | A 20-year-old man comes to the emergency due to bleeding after a tooth extraction. The bleeding has persisted for approximately 30 minutes despite constant direct pressure. He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family histo... | I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove... | Inclusion Criteria:
- congenital Hemophilia A and B patients more than 18 years old
Exclusion Criteria:
- All hemophilia patient less than 18 years old
- Patients with other bleeding disorders
- Patients with other comorbidities that can affect joint function as ... | Quality of Life in Hemophilia by Clinical Scoring System (FISH)Score | NCT04102046 | Entailment |
100 | 1 | A 19-year-old male came to clinic with some sexual concern. He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates. On physical examination, there is some pubic hair and poo... | I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me sm... | Inclusion Criteria
- General good health and capable of undergoing strength testing
- Normal testosterone (300-1100 ng/dL), LH, and FSH levels
Exclusion Criteria
- Currently participating in competitive sports
- Mental state that would preclude complete understan... | The Effect of 5-Alpha Reductase on Testosterone in Men | NCT00070733 | Contradiction |
3,185 | 23 | A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn. The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness. She also reports occasional joint pain. Medical history... | I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to t... | Selection of subjects for the study will be restricted to the pool of NIDCR patients
already participating in protocol 84-D-0056, Evaluation and Treatment of Salivary
Dysfunction.
INCLUSION CRITERIA
A. Salivary Flow = 0.1ml/min pooled unstimulated; and
B. A diagnosis of SS (pr... | Study of Oral Bacteria in Patients With Dry Mouth | NCT00048685 | Entailment |
2,345 | 15 | An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity m... | I brought my 8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weak... | Inclusion Criteria:
- Diagnosed with Duchenne Muscle Dystrophy
- No injuries and no neurological or orthopedic surgery in the last 6 months
- No other systemic or orthopedic / neurological disorders to prevent exercise
Exclusion Criteria:
-
Male
No healthy subjects ... | The Effects of Trunk Exercises on Upper Extremity and Respiratory Functions in DMD | NCT04669847 | Entailment |
5,090 | 39 | A 55-year-old white woman comes for a routine checkup. She has no significant medical history and does not use tobacco, alcohol, or illicit drugs. The patient's only medication is an over-the-counter multivitamin. Family history is notable for a hip fracture in her mother. Blood pressure is 130/80 mm Hg and pulse i... | I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse w... | Inclusion Criteria:
Postmenopausal women who meet at least one of the following bone mineral density (BMD) and
fracture criteria:
- BMD T-score at the total hip or femoral neck of ≤ -2.50 and EITHER:
- at least 1 moderate (semiquantitative grade [SQ]2) or severe (SQ3) verte... | Study to Determine the Efficacy and Safety of Romosozumab in the Treatment of Postmenopausal Women With Osteoporosis | NCT01631214 | Contradiction |
6,065 | 44 | A 48-year-old man comes to the office complaining of heartburn and acid reflux. He has taken over-the-counter antacids but sees no relief. Other medical history is unremarkable. The patient does not use tobacco, alcohol, or illicit drugs. Vital signs are within normal limits. BMI is 31 kg/m2. Physical examination... | I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old gu... | Inclusion Criteria:
- Heartburn (defined as a feeling of burning or pain, rising from the epigastrium or
lower part of the chest up towards the neck) with or without regurgitation
- Patients must have had episodes of heartburn with or without regurgitation for 3
months ... | A Study to Compare the Number of Patients With Gastro-Oesophageal Reflux Disease (GORD) Achieving Heartburn and Regurgitation Symptom Resolution After Treatment With Either Rabeprazole Sodium 20mg, Esomeprazole 20mg or Esomeprazole 40mg | NCT00464308 | Entailment |
6,667 | 48 | A 20-year-old man comes to the emergency due to bleeding after a tooth extraction. The bleeding has persisted for approximately 30 minutes despite constant direct pressure. He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family histo... | I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove... | Inclusion Criteria:
- Adult or child with Clinical diagnosis of severe hemophilia A (FVIII activity < 1%)
with or without inhibitor
- Clinical indication to emicizumab therapy
Exclusion Criteria:
- Refusal to give informed consent
- acquired hemophil... | UPLC-MS/MS Monitoring of Emicizumab Therapy | NCT04472169 | Contradiction |
3,087 | 22 | A 15-year-old boy with mild intellectual disability is brought to the office by his parents for a routine physical examination. The boy is going to a school for students with learning disabilities. The patient was adopted, and his immunizations are up to date. Review of the patient's medical records is notable for c... | My husband and I brought our 15-year-old son to the clinic for his routine exam. My son is going to school for special needs students. We adopted him a few years ago. His vaccinations are up to date. He already passed some chromosome testing and they found that he has a fragile X syndrome. The doctor told us that it co... | Inclusion Criteria:
- Patients born between 1990 and 2005, have been cared by Dr Schlumberger in 2014 in the
center of language and learning disorders at Raymond Poincaré hospital;
- With severe learning disorders: deficiency in school work, need at least one medical
ap... | Learning and Executive Function Disorders in Children and Psychosis Risk at Adult-age | NCT04280367 | Entailment |
4,968 | 38 | A 60-year-old man comes to the clinic complaining of hand tremor that started few months ago. It is most bothering when he wants to drink from a glass or pour from a bottle. He does not smoke, but drinks occasionally. He recently started consuming more alcohol as his tremor subsides somewhat when he drinks small amoun... | I'm only a 60 years old man but I already suffer from shaky hands. It started a few months ago, and it really bothers me when I want to pour myself a glass or even while drinking. I don't smoke, but I drink alcohol from time to time. To be honest, I've been drinking a little more lately since it helps me with the shaki... | Inclusion Criteria:
1. Dopa responsiveness
2. Minimum disease duration of 5 years.
3. Diagnosis of idiopathic Parkinsons disease
4. Patients with intractable Essential Tremors.
5. Patients with intractable dystonia
Exclusion Criteria:
1. Signifi... | DBS in the Treatment of Intractable Movement Disorders | NCT03562403 | Entailment |
3,222 | 23 | A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn. The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness. She also reports occasional joint pain. Medical history... | I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to t... | Inclusion Criteria:
- A diagnosis of primary Sjogren's syndrome according to the revised American-European
Consensus Group (AECG) criteria
- ESSDAI score greater than or equal to (>/=) 5
- ESSPRI score >/=5
- Elevated serum titers of anti-Sjogren's-syndrome-r... | A Study to Assess the Efficacy of RO5459072 in Participants With Primary Sjogren's Syndrome | NCT02701985 | Entailment |
609 | 2 | A 32-year-old woman comes to the hospital with vaginal spotting. Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with ... | I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing... | Inclusion Criteria:
- Confirmed diagnosis of missed miscarriage on pelvic ultrasound
- Gestational age ≤ 13 weeks
Exclusion Criteria:
- Patients who opted for surgical or expectant management.
- Patients with co-morbidity
Female
Accepts Healthy Volunteers
Subject... | Comparison of Vaginal Versus Sublingual Misoprostol in the Treatment of First Trimester Missed Miscarriage | NCT04604366 | Entailment |
1,740 | 10 | A 19-year-old girl comes to the clinic due to a left wrist mass. She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns. Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient n... | I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penli... | Inclusion Criteria:
- Patients in different age groups with superficial soft tissue lesions
Exclusion Criteria:
- If the patient undergo previous operations at the same mass that could change the
criteria of that mass or if the mass is recurrent at the same site.
No conditi... | Doppler Ultrasound in Characterization of Superficial Soft Tissue Masses | NCT03171857 | Entailment |
2,660 | 20 | A 49-year-old man comes to the office because of the bulging in his groin. Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases. His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications... | I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to... | Inclusion Criteria:
- Adult (>18 years)
- Male
- Primary unilateral groin hernia
- Ability to use pain scales
Exclusion Criteria:
- Neurological disease
- Diabetes with late stage complications
Male
No healthy subjects accepted to join the... | Predisposing Factors for Chronic Postherniotomy Pain | NCT00649142 | Entailment |
5,299 | 39 | A 55-year-old white woman comes for a routine checkup. She has no significant medical history and does not use tobacco, alcohol, or illicit drugs. The patient's only medication is an over-the-counter multivitamin. Family history is notable for a hip fracture in her mother. Blood pressure is 130/80 mm Hg and pulse i... | I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse w... | Inclusion Criteria: healthy women ages 55 and older who were at least four years
postmenopausal living independently in a nine-county rural area of Nebraska
-
Exclusion Criteria:
1) chronic kidney disease, 2) Paget's metabolic bone disease, and 3) history of cancer
except for ... | Calcium and Vitamin D Malnutrition in Elderly Women | NCT00352170 | Entailment |
6,684 | 48 | A 20-year-old man comes to the emergency due to bleeding after a tooth extraction. The bleeding has persisted for approximately 30 minutes despite constant direct pressure. He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family histo... | I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove... | Inclusion Criteria:
- Patient of the Hemophilia Treatment Center at OHSU
- Male
- Aged 4 years, 0 months to 21 years, 11 months
- Diagnosis of bleeding disorder
Exclusion Criteria:
- Acute bleed or injury in the last two weeks that prevents activity
... | Motor Proficiency of People With Bleeding Disorders Using the BOT-2 (TM) | NCT02279199 | Contradiction |
3,096 | 22 | A 15-year-old boy with mild intellectual disability is brought to the office by his parents for a routine physical examination. The boy is going to a school for students with learning disabilities. The patient was adopted, and his immunizations are up to date. Review of the patient's medical records is notable for c... | My husband and I brought our 15-year-old son to the clinic for his routine exam. My son is going to school for special needs students. We adopted him a few years ago. His vaccinations are up to date. He already passed some chromosome testing and they found that he has a fragile X syndrome. The doctor told us that it co... | Inclusion Criteria:
- Patients with FXS as confirmed by genetic testing
Exclusion Criteria:
- none
- Other protocol-defined inclusion/exclusion criteria may apply
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
| EXPLAIN -FragilE X Registry: An exPlorative Longitudinal Study for chAracterIzation, Treatment Pathways and patieNt-related Outcomes | NCT01711606 | Entailment |
347 | 2 | A 32-year-old woman comes to the hospital with vaginal spotting. Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with ... | I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing... | Inclusion Criteria:
- Infertile female age 20-35 years
- Previous Failed one ICSI trial
- normal basal hormonal profile [FSH, LH] 3-10 mIU/ml and 1.8-8.5 mIU/ml respectively,
--normal endometrial cavity
- patent tubes
- normal Husband semen analys... | Physical Endometrial Manipulation and Its Effect on ICSI | NCT03345251 | Contradiction |
3,040 | 22 | A 15-year-old boy with mild intellectual disability is brought to the office by his parents for a routine physical examination. The boy is going to a school for students with learning disabilities. The patient was adopted, and his immunizations are up to date. Review of the patient's medical records is notable for c... | My husband and I brought our 15-year-old son to the clinic for his routine exam. My son is going to school for special needs students. We adopted him a few years ago. His vaccinations are up to date. He already passed some chromosome testing and they found that he has a fragile X syndrome. The doctor told us that it co... | Inclusion Criteria:
- fragile X full mutation
- normal or corrected vision
- English or Spanish speaking
- ability to pass three-span items following completion of a Cogmed training session at
baseline
- parental agreement to maintain adherence to... | Cognitive Training for Fragile X Syndrome | NCT02747394 | Entailment |
5,255 | 39 | A 55-year-old white woman comes for a routine checkup. She has no significant medical history and does not use tobacco, alcohol, or illicit drugs. The patient's only medication is an over-the-counter multivitamin. Family history is notable for a hip fracture in her mother. Blood pressure is 130/80 mm Hg and pulse i... | I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse w... | Inclusion:
- Informed consent: Subject is willing and able to provide written informed consent.
- Menopausal status: Ambulatory female aged < 80 years at screening and >5 years
postmenopausal.
- T-Score: A subject with either no or only one prevalent vertebral fracture i... | A Phase II Study Evaluating SB-751689 in Post-Menopausal Women With Osteoporosis. | NCT00471237 | Entailment |
4,205 | 32 | A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia. The patient is sexually active with his wife and does not use any contraception methods. They have been trying to conceive for the past year with no success. The patient has a past medical history of recurrent p... | I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet ... | Inclusion Criteria:
- Male or female aged 18 to 75 years.
- Confirmed diagnosis of a persistent cough.
- Leicester Cough Questionnaire score of ≤ 17 at baseline.
- FEV ≥ 70% of predicted normal, at screening. See protocol Appendix 4 for formula for
calculatin... | Study of the Safety and Effectiveness of BC1036 Capsules to Treat Frequent Long-Term Cough | NCT01656668 | Contradiction |
6,896 | 50 | A 70-year-old man comes to the office accompanied by his wife. The patient has experienced progressive memory loss over the last years. He needs help with some of his routine activities, such as paying bills. The patient's wife says, "He used to be such an independent person, but now he needs help with many things, ... | I am a 70-year-old man, and I paid a visit to the doctor with my wife the other day. I noticed that I tend to forget small things and that my memory has decreased over the past few years. I even ask my wife to help me out with my daily routine. I used to be the one paying the bills, but now she has to give me a hand. M... | Inclusion Criteria:
Three groups of participants are sought to take part in the survey:
- 70 primary caregivers(current or former) of persons with AD, or related memory
disorders
- 70 adult children and siblings of people with AD or related memory disorders
- 70... | Alzheimer's Disease Treatment and Illness Perceptions Survey (TIPS) II | NCT00059410 | Entailment |
1,394 | 8 | A 7-month-old boy is brought to emergency by his parents due to irritability and inability to defecate for the past 3 days. The patient has had constipation and discomfort with bowel movements since birth. His symptoms worsened after eating semi-solid foods. Vital signs are normal. Abdominal examination shows diste... | My baby boy just turned 7 months old but my wife and I cannot get a hold of him! He has not been able to poop for 3 days! My poor little thing has been having constipation and bowel problems since birth. But since he ate some semi-solid food it has just been worse! The doctor said his vitals are normal but his belly is... | Inclusion Criteria:
1. Children aged 0-2 years.
2. Clinical diagnosis with Hirschsprung's disease who requires surgery;
Exclusion Criteria:
1. Complicated with severe complications such as enterocolitis associated with
Hirschsprung disease;
2. History of... | Nutrition Support for Hirschsprung Disease | NCT04598841 | Entailment |
42 | 1 | A 19-year-old male came to clinic with some sexual concern. He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates. On physical examination, there is some pubic hair and poo... | I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me sm... | Inclusion Criteria:
- Male Veterans with low total testosterone (<300 ng/dl) as defined by the Endocrine
Society, who are between 40-75 years of age.
- These patients must be ambulatory; and be willing and able to provide written informed
consent.
Exclusion Cri... | CYP19A1 (Cytochrome P450 Family 19 Subfamily A Member 1) Gene and Pharmacogenetics of Response to Testosterone Therapy | NCT01378299 | Contradiction |
2,824 | 21 | A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year. Over the last few months, he has also noticed weakness in the right upper extremity. BP is 120/75, PR is 80 and temperature is 37 C. Reflex... | I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rat... | - INCLUSION CRITERIA:
Research patients will be studied under this protocol if they fulfill the following
criteria:
Have an identifiable neuromuscular disorder that may be suitable for a specific current or
future protocol;
Present a diagnostic puzzle in spite of the previous... | Diagnostic Evaluation of Patients With Neuromuscular Disease | NCT00015470 | Entailment |
6,924 | 50 | A 70-year-old man comes to the office accompanied by his wife. The patient has experienced progressive memory loss over the last years. He needs help with some of his routine activities, such as paying bills. The patient's wife says, "He used to be such an independent person, but now he needs help with many things, ... | I am a 70-year-old man, and I paid a visit to the doctor with my wife the other day. I noticed that I tend to forget small things and that my memory has decreased over the past few years. I even ask my wife to help me out with my daily routine. I used to be the one paying the bills, but now she has to give me a hand. M... | Inclusion Criteria:
- Between 55 and 90 years of age
- Study partner to accompany patient to all clinic visits for the duration of the
protocol
- Memory complaint by patient and/or study partner
- Abnormal memory function score on Wechsler Memory Scale (adjus... | Evaluation of a Computerized Complex Instrumental Activities of Daily Living Marker (NMI) | NCT02843529 | Entailment |
6,637 | 48 | A 20-year-old man comes to the emergency due to bleeding after a tooth extraction. The bleeding has persisted for approximately 30 minutes despite constant direct pressure. He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family histo... | I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove... | Inclusion Criteria:
- History of moderate or severe congenital hemophilia A or B with or without inhibitors
to Factor VIII (FVIII) or Factor IX (FIX)
- Male subjects 18-65 years of age inclusive
- Able to dismiss factor replacement therapy during the course of the study ... | Study of FVIIa Variant BAY86-6150 (B0189) in Subjects With Moderate or Severe Hemophilia Types A or B With or Without Inhibitors | NCT01921855 | Contradiction |
4,576 | 35 | A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles. The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days. She is sexually active with her husband and... | I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of ... | Inclusion Criteria:
- The inclusion criteria for RIF group were: unexplained repeated implantation failure
(RIF) is defined as the absence of a gestational sac on ultrasound at 5 or more weeks
after embryo transfer (ET) after 3 embryo transfers with high quality embryos or after
... | Transcriptomic Profile of Endometrium in Different Histological Dating of Natural Cycle | NCT03222830 | Contradiction |
3,670 | 29 | A 57-year-old man comes to the emergency department due to constipation. His last bowel movement was 2 days ago. He complains of spending about 30 minutes once attempting to defecate. He also has lower back pain. There is no history of trauma. The pain is not relieved with over-the-counter pain medications. His vita... | I'm a 57 year-old-man, and I had to go to the ER because I couldn't go defecate. My last trip to the toilet was 2 days ago, and I tried too many times, during 30 min, to get my poop to get out. I also have terrible lower back pain. The doctor did not notice any trauma. I tried to get the pain away using over-the-counte... | Inclusion Criteria:
- Must have Informed Consent Signed
- Lumbar Disc Herniations under 5mm without Sequestered Fragments
- Lumbar Disc Bulging
- Lumbar Degenerative Disc Disease (mild and moderate severity)
- Non-pregnant Females and Males suffering from Chro... | A Comparative Study: Non-Surgical Spinal Decompression and Spinal Manipulative Therapy- Utilizing a Quantifiable Musculoskeletal Functional Assessment Risk Analysis Tool (MSDR®) in Patients With Chronic Low Back Pain | NCT00732394 | Contradiction |
2,522 | 18 | A 2-year-old boy is brought to the office by his parents due to a rash that started 1 week ago. A similar red, itchy rash on the cheeks, trunk, and arms has occurred intermittently since infancy. The patient has had a few upper respiratory infections but no major illnesses. Vaccinations are up to date, and he takes ... | I just brought my two-year-old son to the doctor's office because he had a rash for like one week. His rash was on the cheeks, the trunk, and his arms. He already had this before, and it keeps coming back from time to time to time. In the past, he had some respiratory infections but he has never been this sick. His vac... | Inclusion Criteria:
- AD diagnosis by dermatologist or allergist based on Hanifin and Rajka criteria
- 5% or more treatable body surface area involvement
- baseline Investigator's Static Assessment (ISGA) score of mild (2) or moderate (3)
- patient on stable regimens (con... | Response of Children With Atopic Dermatitis (Eczema) to Eucrisa | NCT04023084 | Entailment |
1,348 | 7 | A 3-year-old girl is brought to the clinic by her parents for assessment of her short stature. Physical examination reveals short limbs and a relatively large head. She has a flat nasal bridge and a small midface. The girl's father exhibits similar physical features; however, her mother looks normal. The genetic testin... | I just brought my little 3-year-old girl to the clinic to have her checked up by the doctor. I was worried sick because she was smaller than her classmates. The lovely doctor performed a physical exam and she told me that she has short limbs and a larger head. My girl also has a flat nasal bridge and a small midface. M... | Inclusion Criteria:
1. Diagnosis: Suspicion of genetic disease. (Only one of the following criteria is
required.) [1.1] Family member(s) with similar phenotype OR [1.2] At least two
affected organ systems OR [1.3] One affected organ system that is known to be
associated... | Mutation Exploration in Non-acquired, Genetic Disorders and Its Impact on Health Economy and Life Quality | NCT02380729 | Entailment |
4,242 | 32 | A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia. The patient is sexually active with his wife and does not use any contraception methods. They have been trying to conceive for the past year with no success. The patient has a past medical history of recurrent p... | I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet ... | Inclusion Criteria:
- Eligible couples are those undergoing ICSI due to azoospermia with testicular biopsy
positive for sperm (either fresh or cryopreserved) following testicular sperm
extraction (TESE) or aspiration (TESA).
Exclusion Criteria:
- Cases with fem... | Laser Assisted Sperm Selection of Viable Immotile Testicular Sperm in Azoospermic Infertile Men | NCT04675164 | Entailment |
5,749 | 43 | A 27-year-old woman comes to the dermatology clinic with skin rash and oral ulcers. The rashes are mildly itchy. The patient has no other medical conditions and takes no medications. Vital signs are normal. On examination, there are pink papules symmetrically distributed over the anterior surfaces of the shins and a... | I went to the dermatologist because I had rashes on my skin and ulcers in my mouth. The rashes were not that itchy. I don't get it! I'm 27, I don't take medication, nor I don't have any other illnesses. My vitals were normal. My doc told me there were pink spots on the back of my throat. I'm heterosexual and have been ... | Inclusion Criteria:
Each participant must meet all of the following inclusion criteria to participate in this
study:
1. Must be 18 years or older at time of consent.
2. Patients must have clinically active OLP that is being considered for systemic
therapy; and an oral... | Apremilast - Oral Lichen Planus Trial | NCT03836885 | Contradiction |
1,399 | 9 | A 67-year-old woman comes to the clinic due to recent episode of choking, dysphagia, and cough. Her other medical problems include hypertension, dyslipidemia, and osteoarthritis. She does not smoke or use alcohol. She lives with her husband and she is able to do her own daily activities. She used to teach elementary ... | I'm a 67-year-old lady, and I went to the clinic due to nonstop choking, difficulty swallowing, and coughing. I also suffer from hypertension, cholesterol, and osteoarthritis. I do not smoke or drink alcohol. I live with my husband, and we are independent retired elementary school teachers. During the exam, my blood pr... | Inclusion Criteria:
- Documented resistant hypertension (RH). In the absence of a specific RH diagnosis,
individuals being treated for two or more weeks with 3 antihypertensive medications of
different classes, including a diuretic if tolerated, with clinic SBP ≥ 130 mm Hg or
... | Lifestyle Interventions in Treatment-Resistant Hypertension | NCT02342808 | Contradiction |
2,112 | 12 | A 47-year-old man comes to the office for routine checkup. He is complaining of chronic cough and occasional but progressive dyspnea. Other medical conditions include hypertension and osteoarthritis. The patient smokes a pack of cigarettes daily and does not use alcohol or illicit drugs. He used to be a construction... | I'm a 47-year-old former construction worker. I'm a man and I smoke a pack of cigs a day but I don't drink or do drugs. I went to my routine checkup because I've been coughing so much lately. I also had shortness of breath and it got worse over time. I already suffer from hypertension and osteoarthritis. My doctor foun... | Inclusion Criteria:
- Chest radiograph or computed tomography scan of the thorax (within 5 years of
Screening/Visit 1 and after the onset of chronic cough) not demonstrating any
abnormality considered to be significantly contributing to the chronic cough or any
other c... | A Study of Gefapixant (MK-7264) in Adult Participants With Chronic Cough (MK-7264-030) | NCT03449147 | Entailment |
1,029 | 4 | A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes. The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief. Past medical history is notable for hypertension and hypercholesteremia. ... | I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tyl... | Inclusion Criteria:
- OA in at least one hand as defined by ACR Criteria (nodal enlargement in two or more
of 10 defined joints, CMC-1, MCP=1, PIPs and DIPs).
- Hand pain duration greater than one year.
- History of NSAID use for hand pain on at least one occasion during... | The Analgesic Activity of a Topical Formulation in Patients With Osteoarthritis of the Hands | NCT02485145 | Entailment |
4,775 | 36 | A 47-year-old woman comes to the clinic complaining of dizziness. She also has occasional nausea and ringing in her right ear. The patient also has difficulty hearing while holding her phone to the left ear, although hearing in her right ear is normal. The dizziness improves spontaneously, and she feels fine between... | The other day, I had to go to the clinic due to severe dizziness. I'm 47 years old, and I've been suffering from nausea and ringing in my right ear. I also have difficulty hearing in my left ear while I hold my phone, even if my hearing in my right ear is normal. The dizziness just gets me all of a sudden but I don't h... | Inclusion Criteria:
- Patients with subjective, chronic tinnitus
Exclusion Criteria:
- Enrollment in other tinnitus treatments simultaneously at the time of the intervention
No condition on gender to be admitted to the trial.
Subject must be at least 18 Years old.
| Internet-delivered Group Counseling for Chronic Tinnitus | NCT04382807 | Entailment |
3,497 | 25 | A 50-year-old woman comes to the clinic with intermittent ear discharge and sense of hearing loss on her left ear. Past medical history is significant for obesity, hyperlipidemia, and diabetes mellitus. Her medications include Metformin, Atorvastatin and Vit D supplement. Vital signs are normal. BMI is 37. Otoscopy s... | I went to the clinic the other day because I had some fluid in my ear and I felt like I could not hear as well as I used to in my left ear. I'm a 50-year-old woman, and I have been obese for a while now. I have diabetes and cholesterol. I take some medication. I take metformin, atorvastatin, and vitamin D supplements. ... | Inclusion Criteria:
- 18-50 years old
- at least one intact and effusion-free middle ear
Exclusion Criteria:
- bilateral otitis media
- unable to remain relaxed and quiet for up to 2 hours
No condition on gender to be admitted to the trial.
Accepts Healthy Volunt... | Gas Supply, Demand and Middle Ear Gas Balance: Specific Aim 3c | NCT00422851 | Entailment |
1,322 | 7 | A 3-year-old girl is brought to the clinic by her parents for assessment of her short stature. Physical examination reveals short limbs and a relatively large head. She has a flat nasal bridge and a small midface. The girl's father exhibits similar physical features; however, her mother looks normal. The genetic testin... | I just brought my little 3-year-old girl to the clinic to have her checked up by the doctor. I was worried sick because she was smaller than her classmates. The lovely doctor performed a physical exam and she told me that she has short limbs and a larger head. My girl also has a flat nasal bridge and a small midface. M... | Inclusion Criteria:
- Diagnosis of ACH, confirmed by genetic testing
- Age 0 to < 60 months at study entry (Day 1)
- At least 6-month period of pretreatment growth assessment in Study 111-901 immediately
before study entry (cohort 1 & 2) or at least 3 months of observati... | A Clinical Trial to Evaluate the Safety and Efficacy of BMN 111 in Infants and Young Children With Achondroplasia | NCT03583697 | Contradiction |
167 | 1 | A 19-year-old male came to clinic with some sexual concern. He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates. On physical examination, there is some pubic hair and poo... | I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me sm... | Inclusion Criteria
1. Male patients >= 18 years of age
2. Hypogonadism not previously treated with testosterone
3. Testosterone deficiency confirmed clinically and biochemically
4. Being prescribed AndroGel® 1% in accordance with the local summary of product
char... | ESPRIT Study in Hypogonadal Men | NCT01143818 | Entailment |
5,958 | 44 | A 48-year-old man comes to the office complaining of heartburn and acid reflux. He has taken over-the-counter antacids but sees no relief. Other medical history is unremarkable. The patient does not use tobacco, alcohol, or illicit drugs. Vital signs are within normal limits. BMI is 31 kg/m2. Physical examination... | I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old gu... | Inclusion Criteria:
1. Patients with typical reflux symptoms (heartburn and/or acid regurgitation) validated
by standard questionnaire GerdQ.16
2. Aged from 18 to 70 years old.
3. Willing to receive H. pylori eradication therapy.
Exclusion Criteria:
1. S... | Symptom Assessment for GERD Patients Receiving H. Pylori Eradication | NCT01249482 | Contradiction |
2,492 | 17 | A 67-year-old man comes to the clinic with slowly worsening vision in both eyes. He is not able to drive at night, as the symptoms are worse at night. His pupils are normal in diameter both in the light and darkness. Other medical history is unremarkable. Ocular examination shows loss of the red reflex and blurry vis... | I am a 67 years-old man, and I haven't been able to drive at night due to my vision getting worse. My vision is not the best in general, but night makes it even worse. The ophthalmologist told me that my pupils were normal. However, I have slow reflexes and blurry vision. My acuity test came back with 50/100 vision in ... | Inclusion Criteria:
- Older adults living independently;
- medical approval.
Exclusion Criteria:
- Non-smokers;
- Non-morbidly obese;
- No history of severe hypertension;
- No history of falls;
- No orthopaedic, neurological, p... | Study of the Long-term Effects of Exercise on Heath Indicators in Older People | NCT01874132 | Entailment |
1,761 | 11 | A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that show... | I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and m... | Inclusion Criteria:
1. Males and females 18 to 55 years of age.
2. In good general health as confirmed by a medical history and physical exam, vital
signs*, and screening laboratories conducted no more than 30 days prior to study
injection administration.
*T... | Phase 1 Clinical Trial of Single-Vial ID93 + GLA-SE in Healthy Adults | NCT03722472 | Contradiction |
1,446 | 9 | A 67-year-old woman comes to the clinic due to recent episode of choking, dysphagia, and cough. Her other medical problems include hypertension, dyslipidemia, and osteoarthritis. She does not smoke or use alcohol. She lives with her husband and she is able to do her own daily activities. She used to teach elementary ... | I'm a 67-year-old lady, and I went to the clinic due to nonstop choking, difficulty swallowing, and coughing. I also suffer from hypertension, cholesterol, and osteoarthritis. I do not smoke or drink alcohol. I live with my husband, and we are independent retired elementary school teachers. During the exam, my blood pr... | Inclusion Criteria:
- Treated or untreated subjects with concurrent hypertension and dyslipidemia with BP
and LDL-C not at target according to governing guidelines
Exclusion Criteria:
- High liver enzymes
No condition on gender to be admitted to the trial.
No healthy subjec... | Open Label Study To Assess The Effectiveness Of Amlodipine-Atorvastatin Combination In Hypertension And Dyslipidemia. | NCT00174304 | Contradiction |
6,658 | 48 | A 20-year-old man comes to the emergency due to bleeding after a tooth extraction. The bleeding has persisted for approximately 30 minutes despite constant direct pressure. He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family histo... | I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove... | Key Inclusion Criteria:
- Severe hemophilia A defined as <1 IU/dL (<1%) endogenous FVIII
- Male <12 years of age and weight ≥13 kg
- History of at least 50 documented prior exposure days to FVIII
- No current, or history of, inhibitor development to FVIII
Key Exc... | Study to Evaluate the Safety, Efficacy, and Pharmacokinetics of Recombinant Coagulation Factor VIII Fc Fusion Protein (rFVIIIFc) in Previously Treated Pediatric Subjects With Hemophilia A | NCT01458106 | Contradiction |
5,712 | 42 | A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively. On physical examination, the patient's height is in the 5th percentile of her age. Other findings include low-set ears, a high arched palate... | I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a we... | Inclusion Criteria:
- Ages 6-9 regardless of BMI status
Exclusion Criteria:
- non-English-speaking
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 6 Years old.
Subject must be at most 9 Years | BMI Study for Children Ages 6-9 Years and Parents | NCT02421822 | Entailment |
4,487 | 35 | A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles. The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days. She is sexually active with her husband and... | I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of ... | Inclusion Criteria:
1. Comply with all study procedures, sign, initial and date back, of their own free will,
the IC;
2. Women aged between 18 and 35 years, regardless of race and class;
3. Make use of safe non-hormonal method of contraception such as tubal ligation,
... | Evaluation of Ciclo 21® Effect (Levonorgestrel + Ethinyl Estradiol) Compared to Nordette®. | NCT01480778 | Contradiction |
3,512 | 26 | A 33-year-old woman comes to clinic complaining of progressive fatigue, decreased appetite, and 11-lb weight loss in the past 2 months. She uses levothyroxine because of the previously diagnosed Hashimoto disease. She has no other medical conditions and does not use tobacco, alcohol, or illicit drugs. Physical examin... | I went to the clinic because I was really suffering from fatigue and decreased appetite and I also lost 11 pounds over the past two months. I'm just 33 years old so that's not normal, especially for a woman. I take levothyroxine because I have been diagnosed with Hashimoto disease. I don't have any other medical condit... | Inclusion Criteria:
- healthy participants of both sexes
- aged 18-70 year
Exclusion Criteria:
- any clinical suspicion of hypoadrenalism, or any active medical condition or treatment
that might alter blood cortisol levels
- pregnant women and patien... | Standardized 1µg Adrenocorticotropic Hormone Stimulation Test, and Salivary Cortisol Concentration During the Test | NCT02413944 | Contradiction |
1,021 | 4 | A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes. The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief. Past medical history is notable for hypertension and hypercholesteremia. ... | I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tyl... | Inclusion Criteria:
- Osteoarthritis of the hip or knee for a minimum of six months duration requiring
treatment with either an analgesic or anti-inflammatory agent on a regular basis
(greater than or equal to three days/week) for at least three months
- History of oste... | A Safety and Effectiveness Study of Acetaminophen (4000 mg/Day) and Naproxen (750 mg/Day) in the Treatment of Osteoarthritis of the Hip or Knee | NCT00240773 | Entailment |
3,441 | 25 | A 50-year-old woman comes to the clinic with intermittent ear discharge and sense of hearing loss on her left ear. Past medical history is significant for obesity, hyperlipidemia, and diabetes mellitus. Her medications include Metformin, Atorvastatin and Vit D supplement. Vital signs are normal. BMI is 37. Otoscopy s... | I went to the clinic the other day because I had some fluid in my ear and I felt like I could not hear as well as I used to in my left ear. I'm a 50-year-old woman, and I have been obese for a while now. I have diabetes and cholesterol. I take some medication. I take metformin, atorvastatin, and vitamin D supplements. ... | Inclusion Criteria:
- Have a body mass index (BMI) between 27 to 45 kilograms per meter squared (kg/m²),
inclusive at screening
- For nondiabetic subjects: as determined by medical history, physical examination, and
safety assessments at screening
- For part... | A Study to Measure Stomach Emptying in Overweight Non-diabetic and Diabetic Participants Using Tirzepatide | NCT04407234 | Entailment |
4,137 | 32 | A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia. The patient is sexually active with his wife and does not use any contraception methods. They have been trying to conceive for the past year with no success. The patient has a past medical history of recurrent p... | I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet ... | Stakeholders (players, coaches, caregivers, club administrators) of all youth teams (13-17
years) in two community handball clubs will be eligible for participation.
Inclusion Criteria:
- Players: ages 13-17 years and training ≥2 times/week in a team
- Coaches: leading ≥1 traini... | Implementation of the I-PROTECT Model | NCT04481958 | Contradiction |
4,790 | 36 | A 47-year-old woman comes to the clinic complaining of dizziness. She also has occasional nausea and ringing in her right ear. The patient also has difficulty hearing while holding her phone to the left ear, although hearing in her right ear is normal. The dizziness improves spontaneously, and she feels fine between... | The other day, I had to go to the clinic due to severe dizziness. I'm 47 years old, and I've been suffering from nausea and ringing in my right ear. I also have difficulty hearing in my left ear while I hold my phone, even if my hearing in my right ear is normal. The dizziness just gets me all of a sudden but I don't h... | Inclusion Criteria:
Patients with significant tinnitus
Exclusion Criteria:
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
| Evaluation of Treatment Methods for Clinically Significant Tinnitus | NCT00013390 | Entailment |
3,678 | 29 | A 57-year-old man comes to the emergency department due to constipation. His last bowel movement was 2 days ago. He complains of spending about 30 minutes once attempting to defecate. He also has lower back pain. There is no history of trauma. The pain is not relieved with over-the-counter pain medications. His vita... | I'm a 57 year-old-man, and I had to go to the ER because I couldn't go defecate. My last trip to the toilet was 2 days ago, and I tried too many times, during 30 min, to get my poop to get out. I also have terrible lower back pain. The doctor did not notice any trauma. I tried to get the pain away using over-the-counte... | Inclusion Criteria:
Spinal cord injury with bowel & bladder problems
Exclusion Criteria:
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
| Electrical Control of Bladder in Spinal Cord Injury Patients | NCT00011570 | Entailment |
6,539 | 48 | A 20-year-old man comes to the emergency due to bleeding after a tooth extraction. The bleeding has persisted for approximately 30 minutes despite constant direct pressure. He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family histo... | I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove... | Inclusion Criteria:
- Male subjects less than 12 years of age with a documented history of severe hemophilia
A (FVIII:C less than 1%).
- Subjects who are less than 6 years of age must have had at least 50 Exposure Days
(EDs) to prior FVIII products (including blood prod... | Study Evaluating Safety And Efficacy Of Moroctocog Alfa (AF-CC) In Previously Treated Hemophilia A Patients | NCT00914459 | Contradiction |
5,433 | 40 | A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction. Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration. The patient has heavy menstrual cycles each month. She has no other medical problems and takes no medications... | I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical c... | Inclusion Criteria:
- Females of reproductive age who experience monthly menstrual bleedings
- Female Hemophilia A or B carrier (heterozygote, lyonized or Turner's Syndrome)
- FVIII or FIX activity ≤60% at time of the study
- Baseline Pictorial Bleeding Assessment Chart >... | Extended Half Life Factor (EHF) Products For Heavy Menstrual Bleeding in Hemophilia Carriers | NCT03272568 | Entailment |
1,950 | 11 | A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that show... | I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and m... | 1. Required Tumor Parameters
1.1 Patients must have histologically diagnosed adenocarcinoma of the stomach or
gastroesophageal junction. Adenocarcinomas of the esophagus that are not involving the
gastroesophageal junction are not eligible.
1.2 Patients must have ha... | Chemotherapy and Radiation Therapy After Surgery in Treating Patients With Stomach or Esophageal Cancer | NCT00052910 | Entailment |
4,657 | 35 | A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles. The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days. She is sexually active with her husband and... | I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of ... | Inclusion Criteria:
- Aged 18 years of age and over
- Regular menstrual cycles (23-35 days in length)-
Exclusion Criteria:
- Taking any hormonal medications
- Taking any medications that may affect heart rate
- Known heart condition or use of a pacema... | Heart Rate Variability During the Menstrual Cycle | NCT04382001 | Entailment |
3,980 | 30 | A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 chi... | I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 year... | Inclusion Criteria:
- 40 year-old and above
- Diagnosed with unilateral or bilateral knee OA
Exclusion Criteria:
- Patients with current or previous knee surgeries
- Inflammatory arthritis's (rheumatoid arthritis, gout, etc.)
- Alzheimer disease
... | The Effect Of Pulsed Electromagnetic Field And Progressive Resistance Exercise On Knee Osteoarthritis | NCT04106986 | Entailment |
972 | 4 | A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes. The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief. Past medical history is notable for hypertension and hypercholesteremia. ... | I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tyl... | Inclusion Criteria:
- Diagnosis of hand OA, according to the criteria of the American College of
Rheumatology (ACR) (Altman et al., 1990) with involvement of proximal and / or distal
IP joints
- More than 40 years old
- Visual analog scale of pain (VAS of 0-... | Hand Ultrasonography: Clinical and Functional Correlation in Symptomatic Osteoarthritis (OA) | NCT02324192 | Entailment |
513 | 2 | A 32-year-old woman comes to the hospital with vaginal spotting. Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with ... | I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing... | Inclusion Criteria:
- Should be a female subject justifying an In Vitro Fertilization/Embryo transfer
(IVF)/ET treatment
- Should be between 36th and 42nd birthday (both included) at the time of the
randomization visit
- Have early follicular phase (day 2-4)... | A Trial to Compare the Efficacy and Safety of Ovarian Stimulation With GONAL-f® and Luveris® Starting on Day 1 Versus Day 6 in Women Undergoing Assisted Reproductive Technique | NCT01497197 | Contradiction |
6,274 | 46 | The patient is a 38-year-old man with cough and body ache that started 3 days ago. He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within n... | I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my tem... | Inclusion Criteria:
- Having been diagnosed with COVID-19,
- Having been diagnosed in the last 1 week,
- Being between the ages of 18-70,
- Patients who continue to be followed at home
Exclusion Criteria:
- Hospitalization patients
- Havin... | Telerehabilitation for Patients Diagnosed With Coronavirus | NCT04346927 | Entailment |
6,177 | 46 | The patient is a 38-year-old man with cough and body ache that started 3 days ago. He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within n... | I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my tem... | Inclusion Criteria:
- Healthy workers asymptomatic for SARS-CoV-2
- Ability to consent with the study and its procedures
- Age above 18 years old
- Full time employee on site at least 3 full working days a week
- Working in a shared office/lab/manufacturing en... | A Study to Assess the Feasibility of Screening for SARS-CoV-2 Among Healthy Workers | NCT04405466 | Contradiction |
5,086 | 39 | A 55-year-old white woman comes for a routine checkup. She has no significant medical history and does not use tobacco, alcohol, or illicit drugs. The patient's only medication is an over-the-counter multivitamin. Family history is notable for a hip fracture in her mother. Blood pressure is 130/80 mm Hg and pulse i... | I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse w... | Inclusion Criteria:
- Subject is willing and able to provide written informed consent.
- Of Chinese origin - defined as being born in China, having four ethnic Chinese
grandparents.
- Ambulatory woman between the age of 60 and 90 years, inclusive.
- The subje... | Denosumab China Phase III Study | NCT02014467 | Contradiction |
6,742 | 48 | A 20-year-old man comes to the emergency due to bleeding after a tooth extraction. The bleeding has persisted for approximately 30 minutes despite constant direct pressure. He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family histo... | I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove... | Inclusion Criteria:
- Healthy adult patients with one or more teeth to be extracted, from premolar to
premolar
Exclusion Criteria:
- Heavy smokers (more than 10 cig per day)
- Current Pregnant patients
- History of malignancy
- History of... | Healing of Post-ext Sites Using Bovine Bone Mineral: a CBCT and Histologic RCCT | NCT01800149 | Contradiction |
6,154 | 46 | The patient is a 38-year-old man with cough and body ache that started 3 days ago. He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within n... | I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my tem... | Inclusion Criteria:
- Participants must be at high-risk for Coronavirus disease 2019 (COVID-19) disease
progression by fulfilling at least one of the following criteria at screening:
- Presence of chronic pulmonary disease, chronic obstructive pulmonary disease
... | A Trial to Evaluate Safety and Efficacy of Rivaroxaban (COVID-19) | NCT04504032 | Contradiction |
3,495 | 25 | A 50-year-old woman comes to the clinic with intermittent ear discharge and sense of hearing loss on her left ear. Past medical history is significant for obesity, hyperlipidemia, and diabetes mellitus. Her medications include Metformin, Atorvastatin and Vit D supplement. Vital signs are normal. BMI is 37. Otoscopy s... | I went to the clinic the other day because I had some fluid in my ear and I felt like I could not hear as well as I used to in my left ear. I'm a 50-year-old woman, and I have been obese for a while now. I have diabetes and cholesterol. I take some medication. I take metformin, atorvastatin, and vitamin D supplements. ... | Inclusion Criteria:
- Patient requires tympanic membrane closure.
Exclusion Criteria:
- Life expectancy < 12 months
- Known sensitivity to porcine material
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
| Biodesign® Otologic Repair Graft | NCT04635228 | Entailment |
6,661 | 48 | A 20-year-old man comes to the emergency due to bleeding after a tooth extraction. The bleeding has persisted for approximately 30 minutes despite constant direct pressure. He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family histo... | I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove... | Inclusion Criteria:
- Subjects with moderate hemophilia A (baseline factor VIII activity 1-5%) or severe
hemophilia A (baseline factor VIII activity <1%) on prophylactic standard half-life
FVIII infusions OR subjects with moderate or severe hemophilia A who have not started
... | POCUS: Hemostatic Potential and Joint Health in Patients With Severe Hemophilia A on Novel Replacement Therapies | NCT04690322 | Contradiction |
3,457 | 25 | A 50-year-old woman comes to the clinic with intermittent ear discharge and sense of hearing loss on her left ear. Past medical history is significant for obesity, hyperlipidemia, and diabetes mellitus. Her medications include Metformin, Atorvastatin and Vit D supplement. Vital signs are normal. BMI is 37. Otoscopy s... | I went to the clinic the other day because I had some fluid in my ear and I felt like I could not hear as well as I used to in my left ear. I'm a 50-year-old woman, and I have been obese for a while now. I have diabetes and cholesterol. I take some medication. I take metformin, atorvastatin, and vitamin D supplements. ... | Inclusion Criteria:
- Only adult participants ≥ 18 years
- Informed consent form as documented by signature
- Ability to fill in a questionnaire conscientious
- Healthy outer ear (Pinna and ear canal, w/o previous surgical procedures)
Exclusion Criteria:
... | Benchmark Ear Impression Techniques | NCT03303183 | Entailment |
4,575 | 35 | A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles. The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days. She is sexually active with her husband and... | I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of ... | Inclusion Criteria:
- the ages of 18-30,
- being nulliparous,
- having a VAS score of 2 and higher,
- not having a systemic or chronic disease
- not using hormonal contraceptives.
Exclusion Criteria:
- using forms of analgesic and alternat... | Heat Application on Depression, Anxiety, Menstrual Attitude and Dysmenorrhea | NCT04572555 | Contradiction |
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