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3,777 | 30 | A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 chi... | I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 year... | Inclusion Criteria:
- Male or female aged 40 to 85 years with a clinical diagnosis of OA of the target knee
according to the American College of Rheumatology (ACR) criteria, including:
- Symptoms for at least 6 months prior to screening, AND
- Knee pain in the target kne... | A 4-week Study to Evaluate the Efficacy and Safety of HP-5000 in Subjects With Knee Osteoarthritis | NCT03277066 | Entailment |
5,072 | 39 | A 55-year-old white woman comes for a routine checkup. She has no significant medical history and does not use tobacco, alcohol, or illicit drugs. The patient's only medication is an over-the-counter multivitamin. Family history is notable for a hip fracture in her mother. Blood pressure is 130/80 mm Hg and pulse i... | I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse w... | Inclusion Criteria:
Inclusion criteria for both groups:
- Women > 65 y: 2 groups
Inclusion criteria for Osteoporosis group (Alzheimer and non-Alzheimer):
- Osteoporotic femoral neck fracture requiring hip remplacement and fullfilling WHO
definition of osteoporosis.... | Autophagy and Pathological Aging | NCT03175874 | Contradiction |
3,130 | 23 | A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn. The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness. She also reports occasional joint pain. Medical history... | I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to t... | Inclusion Criteria:
1. Subject age is between 40 and 65 years old.
2. Corneal fluorescein staining present in at least one/five sectors of at least one
cornea
3. At least one question out of 6 questions on dry eye symptom present often or all the
time.
... | Trial to Compare the Efficacy of Systane Ultra and Refresh Drop in the Treatment of Dry Eye in Asian Eyes | NCT00796926 | Contradiction |
5,513 | 41 | A 61-year-old man comes to the emergency department complaining of an acute vision disturbance. He had an episode of vision disturbance in the right eye that occurred suddenly and resolved spontaneously in 15 minutes. He also has right jaw pain while chewing. He also complains of fatigue and hip muscle aches over the ... | I’m a 61-year-old man and I came to the ER because I had a sudden episode where I couldn’t see out of my right eye. It only lasted about 15 minutes and went away on its own but it really scared me. I’ve also been having pain in my right jaw when I chew. For the past few months I’ve felt really tired and noticed my hips... | Inclusion Criteria:
- Diagnosis of GCA classified according to age >/=50 years; history of ESR >/=50 mm/hr
or history of CRP >/=2.45 mg/dL; and at least one of the following: unequivocal
cranial symptoms of GCA or symptoms of polymyalgia rheumatica [PMR]; and at least one
... | An Efficacy and Safety Study of Tocilizumab (RoActemra/Actemra) in Participants With Giant Cell Arteritis (GCA) | NCT01791153 | Entailment |
6,377 | 46 | The patient is a 38-year-old man with cough and body ache that started 3 days ago. He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within n... | I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my tem... | A. Inclusion Criteria:
1. Minimum 18 - 80 years of age
2. Clinical Diagnosis of COVID 19 with RT-PCR test for SARS-CoV-2 (If a patient is
COVID19 positive based on Antigen test, they can participate in the trial while
awaiting result form PCR test with Ct-value)
... | Efficacy of Favipiravir in Treatment of Mild & Moderate COVID-19 Infection in Nepal | NCT04694612 | Entailment |
1,498 | 9 | A 67-year-old woman comes to the clinic due to recent episode of choking, dysphagia, and cough. Her other medical problems include hypertension, dyslipidemia, and osteoarthritis. She does not smoke or use alcohol. She lives with her husband and she is able to do her own daily activities. She used to teach elementary ... | I'm a 67-year-old lady, and I went to the clinic due to nonstop choking, difficulty swallowing, and coughing. I also suffer from hypertension, cholesterol, and osteoarthritis. I do not smoke or drink alcohol. I live with my husband, and we are independent retired elementary school teachers. During the exam, my blood pr... | Inclusion Criteria:
- Subject 19 years old and more
- Subject who understands the purpose of the study and signs with informed consent form
- Subject with chronic disease (hypertension, diabetes, dyslipidemia)
- Subject with more than one Poor Disease Control Indicator
... | The Effectiveness of Smart Health Management Program for Patients With Chronic Illness | NCT03294044 | Entailment |
4,170 | 32 | A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia. The patient is sexually active with his wife and does not use any contraception methods. They have been trying to conceive for the past year with no success. The patient has a past medical history of recurrent p... | I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet ... | Inclusion Criteria:
1. Subject is at least 18 years of age.
2. Subject is cooperative and capable of following instructions.
3. Healthy subjects:
1. Never smokers.
2. No known history of respiratory, cardiovascular, hepatic, renal or metabolic
... | Measurement and Evaluation of Total Lung Capacity (TLC) in the Field of Pulmonary Functional Testing (PFT) | NCT01952431 | Contradiction |
5,472 | 40 | A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction. Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration. The patient has heavy menstrual cycles each month. She has no other medical problems and takes no medications... | I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical c... | Inclusion Criteria:
- Patients referred for VWD diagnosis or previously diagnosed with VWD
Exclusion Criteria:
- Patients with other bleeding disorders
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
| Update in VWD Laboratory Diagnosis | NCT03896997 | Entailment |
4,204 | 32 | A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia. The patient is sexually active with his wife and does not use any contraception methods. They have been trying to conceive for the past year with no success. The patient has a past medical history of recurrent p... | I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet ... | Inclusion Criteria:
- Diarrhea
- constipation
Exclusion Criteria:
- Shock
- Sepsis
- Past history with GI tract surgery
- Immunodeficiency
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at le... | Effect of Probiotics on Intestinal Bacterial Population and Immune Modulation | NCT00763399 | Contradiction |
5,709 | 42 | A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively. On physical examination, the patient's height is in the 5th percentile of her age. Other findings include low-set ears, a high arched palate... | I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a we... | Inclusion Criteria:
Participants be included if they are overweight or obese (BMI≥85th %ile) and aged 8-14
years.
Exclusion Criteria:
Participants will be excluded if they 1) are currently taking any medications known to
affect weight or appetite (e.g., antidepressants, steroi... | Ecological Momentary Assessment of Eating Behavior in Overweight Youth | NCT02585518 | Entailment |
4,631 | 35 | A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles. The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days. She is sexually active with her husband and... | I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of ... | Inclusion Criteria:
- Female with persistent (>3months) cyclical period pain associated with menstruation
(defined as 5 or more on VAS).
- Able to give written, Informed consent
- Able to wear device and keep up-to-date records of use
- Agrees to attend follo... | Pulsed Electromagnetic Field Treatment for Painful Periods | NCT03394547 | Entailment |
3,423 | 25 | A 50-year-old woman comes to the clinic with intermittent ear discharge and sense of hearing loss on her left ear. Past medical history is significant for obesity, hyperlipidemia, and diabetes mellitus. Her medications include Metformin, Atorvastatin and Vit D supplement. Vital signs are normal. BMI is 37. Otoscopy s... | I went to the clinic the other day because I had some fluid in my ear and I felt like I could not hear as well as I used to in my left ear. I'm a 50-year-old woman, and I have been obese for a while now. I have diabetes and cholesterol. I take some medication. I take metformin, atorvastatin, and vitamin D supplements. ... | Inclusion Criteria:
- Type 2 Diabetes Mellitus
- BMI more than 25
Exclusion Criteria:
- Type 1 diabetes
- pancreatic diabetes
- presence of concomitant endocrinal disorder
- non-overweight type 2 diabetes
- type 2 diabetes with... | Metformin in Overweight Type 2 Diabetes Mellitus | NCT00922194 | Entailment |
2,263 | 15 | An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity m... | I brought my 8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weak... | Inclusion Criteria:
1. Participant must be a person with DMD who is 11 years or older or The parent/legal
guardian of a person with DMD who is under the age of 18 years.
2. Confirmed diagnosis of DMD with written proof of disease provided
3. Resident of the U.S.
... | Your Voice; Impact of Duchenne Muscular Dystrophy (DMD) on the Lives of Families | NCT03680365 | Contradiction |
4,579 | 35 | A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles. The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days. She is sexually active with her husband and... | I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of ... | Inclusion Criteria:
- symptomatic adenomyosis
- irregular menstrual bleeding and dysmenorrhea .
Exclusion Criteria:
- asymptomatic patients -
- non-lactating patient
- not desire for pregnancy
- no hormonal treatment more than 6 month even... | Role of Dienogest in the Treatment of Patient With Symptomatic Adenomyosis | NCT03654144 | Contradiction |
4,373 | 33 | A 20-year-old man comes to the clinic for his routine checkup. The patient wears glasses for myopia and takes no medications. Vital signs are normal. On physical examination, the patient is tall with long upper extremities and fingers. The face appears narrow with down-slanted palpebral fissures, flattened malar bon... | I'm a 20-year-old guy, working as a driver and I went to the clinic for my routine checkup. I have myopia, so I wear glasses and I don't take any other medications. My vitals were normal. I also did a physical exam, and I was told that I have long legs, arms, and fingers. They also told me that my face is quite narrow,... | Inclusion Criteria: To be in the study, the participant must meet the following criteria
1. Diagnosis of hereditary aortopathy based upon:
- Confirmation of a disease causing mutation in a known aortopathy disorder OR
- Confirmation of disease based on published clinical cri... | Micro RNAs as a Marker of Aortic Aneurysm in Hereditary Aortopathy Syndromes | NCT02213484 | Entailment |
4,773 | 36 | A 47-year-old woman comes to the clinic complaining of dizziness. She also has occasional nausea and ringing in her right ear. The patient also has difficulty hearing while holding her phone to the left ear, although hearing in her right ear is normal. The dizziness improves spontaneously, and she feels fine between... | The other day, I had to go to the clinic due to severe dizziness. I'm 47 years old, and I've been suffering from nausea and ringing in my right ear. I also have difficulty hearing in my left ear while I hold my phone, even if my hearing in my right ear is normal. The dizziness just gets me all of a sudden but I don't h... | Inclusion Criteria:
- mature (above 18 years old) patients that suffer tinnitus (unilateral/bilateral) with
sensorineural hearing loss
Exclusion Criteria:
- patients that are treated for tinnitus( psychological treatment, hearing aid)
- drugs that affect the CNS... | Treating Tinnitus Using Eutectic Mixture of Local Anesthetics (EMLA) 5% Cream | NCT02266160 | Entailment |
638 | 3 | A 51-year-old man comes to the office complaining of fatigue and some sexual problems including lack of libido. The patient doesn't smoke or use any illicit drug. Blood pressure is 120/80 mm Hg and pulse is 70/min. Oxygen saturation is 99% on room air. BMI is 24 kg/m2. Skin examination shows increased pigmentation.... | I am 51 years old and I just came back from the doctor's office. I'm sick and tired of being that exhausted, reaching the point where me and my lovely wife are not touching each other anymore! I'm not smoking or doing drugs! My blood pressure was 120/80 mm Hg, and pulse was 70/min and my oxygen saturation 99%. My BMI i... | Inclusion Criteria:
- Body mass index between 18 et 25 Kg/m²
- Non smoker
- No swallowing disorders
- Normal clinical exam
- Normal ECG
- Normal values for routine biological tests : serum iron, transferrin saturation,,
hemogram ferrit... | Effect of Curcumin on Iron Metabolism in Healthy Volunteer | NCT01489592 | Contradiction |
1,602 | 10 | A 19-year-old girl comes to the clinic due to a left wrist mass. She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns. Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient n... | I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penli... | Inclusion Criteria:
- no participation in a similar study 2-weeks prior
- may be post-menopausal or have had a hysterectomy
- if sexually active, and of child bearing potential, subjects using adequate
non-barrier method of birth control
- free from any vagin... | A Single-Center, Clinical Study to Evaluate the Safety of a New Personal Lubricant in Healthy Female Subjects | NCT02737852 | Contradiction |
2,343 | 15 | An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity m... | I brought my 8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weak... | Inclusion Criteria:
- Subject has a diagnosis of Duchenne muscular dystrophy (DMD) (confirmed by Central
Genetic Counselor) defined as a clinical picture consistent with typical DMD and 1 of
the following:
- Dystrophin immunofluorescence and/or Western blot showing... | A Study to Assess the Safety, Tolerability and Preliminary Efficacy of ASP0367 (MA-0211) in Pediatric Male Participants With Duchenne Muscular Dystrophy (DMD) | NCT04184882 | Entailment |
843 | 4 | A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes. The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief. Past medical history is notable for hypertension and hypercholesteremia. ... | I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tyl... | Inclusion Criteria:
- Male or Female between the ages of 45 years or older
- Ultrasonography scale of 0-3 for grading of primary Knee OA of the knee(s)
- Pain perceived as a minimum of 3/10 on a 0-10 pain scale with 24 hours of the each
visit
- No phobia of e... | The Effects of Transcutaneous Electrical Nerve Stimulation on People With Knee Osteoarthritis (OA) and or Chronic Pain | NCT04084236 | Entailment |
3,871 | 30 | A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 chi... | I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 year... | Inclusion Criteria:
- Primary Knee osteoarthritis (ACR criteria)
- VAS for knee pain between 3 and 7
- No changes the NSAID intake or physical activity in the previous 3 months
Exclusion Criteria:
- Symptomatic heart or pulmonary disease
- Severe syst... | Effectiveness of Cane in Osteoarthritis (OA) Patients | NCT00698412 | Entailment |
2,832 | 21 | A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year. Over the last few months, he has also noticed weakness in the right upper extremity. BP is 120/75, PR is 80 and temperature is 37 C. Reflex... | I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rat... | Inclusion Criteria:
- patients > 18 years-old
- ALS certain or probable
- vital capacity (respiratory) > 70 %
- under riluzole
Exclusion Criteria:
- ALS in family
- other conditions affected survival and QoL
- cognitive impairm... | Effects of Gastrostomy on Amyotrophic Lateral Sclerosis | NCT00337402 | Entailment |
2,576 | 20 | A 49-year-old man comes to the office because of the bulging in his groin. Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases. His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications... | I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to... | Inclusion Criteria:
- Adult ( more than 18 years old) patients with chronic pain after groin hernia surgery,
and pain related impairment of everyday function. The pain should have occurred after
previous open surgery.
- The patient should be able to locate to a specific... | Selective Neurectomy and Mesh Removal for Chronic Postherniotomy Pain | NCT00627289 | Contradiction |
2,769 | 20 | A 49-year-old man comes to the office because of the bulging in his groin. Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases. His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications... | I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to... | Inclusion Criteria:
ASA I-III patients undergoing inguinal hernia repair with a mesh
age between 18 and 75 years old
ability to read and write greek
-
Exclusion Criteria:
- Inability to consent to the study
- BMI >40kg/m2
- Skin infection ... | Transversus Abdominis Plane Block and Inguinal Hernia Repair | NCT02030223 | Entailment |
2,466 | 16 | A 39-year-old woman comes to the clinic complaining of arthralgias and nodules on her legs. She has no fever or other skin rashes. The prior medical condition is unremarkable, and she takes no medications. On physical examination, there is moderate hepatomegaly. The lesions on her legs are tender and present predomin... | I'm just a 39-year-old young woman but lately I have noticed some underlying cysts on my legs and my joints were hurting so much. I don't have a fever. I don't have rashes. My medical history is totally clean and I don't take any medication. When I went to the clinic they did a physical examination where they found tha... | Inclusion Criteria:
1. Male or Female aged over 18
2. Diagnosed with sarcoidosis by either; biopsy confirming non-caseating granulomas
consistent with sarcoidosis, or multi-disciplinary interstitial lung disease meeting
diagnosis of sarcoidosis.
3. Ambulatory p... | A Comparison of Accelerometers for Measuring Daily Activity in Sarcoid | NCT02626897 | Entailment |
5,561 | 42 | A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively. On physical examination, the patient's height is in the 5th percentile of her age. Other findings include low-set ears, a high arched palate... | I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a we... | PROTOCOL ENTRY CRITERIA:
Turner's syndrome-compatible karyotype No Y material in peripheral karyotype Bone age no
greater than 11 years --Prior/Concurrent Therapy-- No more than 12 months of prior
estrogen, androgen, or growth hormone
Female
No healthy subjects accepted to join the trial.
Subje... | Oxandrolone Compared With a Placebo on Growth Rate in Girls With Growth Hormone-Treated Turner's Syndrome | NCT00004275 | Contradiction |
5,793 | 43 | A 27-year-old woman comes to the dermatology clinic with skin rash and oral ulcers. The rashes are mildly itchy. The patient has no other medical conditions and takes no medications. Vital signs are normal. On examination, there are pink papules symmetrically distributed over the anterior surfaces of the shins and a... | I went to the dermatologist because I had rashes on my skin and ulcers in my mouth. The rashes were not that itchy. I don't get it! I'm 27, I don't take medication, nor I don't have any other illnesses. My vitals were normal. My doc told me there were pink spots on the back of my throat. I'm heterosexual and have been ... | Inclusion Criteria:
- greater than or equal to age 18 (as NRT is not FDA approved for adolescents)
- self-report smoking cigarettes
- positive cotinine test
- motivated to quit
- own a smart phone, laptop, desktop, or tablet computer
- able to join... | The Positively Quit Trial for Smoking Cessation | NCT04449458 | Contradiction |
5,231 | 39 | A 55-year-old white woman comes for a routine checkup. She has no significant medical history and does not use tobacco, alcohol, or illicit drugs. The patient's only medication is an over-the-counter multivitamin. Family history is notable for a hip fracture in her mother. Blood pressure is 130/80 mm Hg and pulse i... | I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse w... | Inclusion Criteria:
- : patients with back pain who have been referred to the North of England regional back
pain service who consent to take part in the study
Exclusion Criteria:
- Exclusion criteria are patients with red flag indicators where immediate referral to
... | A Comparison of Two Self-management Programmes for Patients With Back Pain | NCT03791164 | Entailment |
425 | 2 | A 32-year-old woman comes to the hospital with vaginal spotting. Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with ... | I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing... | Inclusion Criteria:
- Body mass index (BMI) 18-30 kg / m2
- Patent tubes
- Regular cycles (26-35 days)
- FSH levels on day 3 of cycle (<10 mIU / ml)
- Estradiol levels on day 3 of cycle (<60 pg / ml)
- Progesterone levels the day of hCG (> 1 ng / m... | IUI Schedule in Cases of High Progesterone | NCT02447588 | Contradiction |
3,172 | 23 | A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn. The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness. She also reports occasional joint pain. Medical history... | I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to t... | Inclusion Criteria:
- Subject is female between the ages of 18 and 49 years (at lease 21 subjects) or 50-60
years (no more than 9 subjects);
- Subject is using adequate non-barrier method of birth control [established us of
hormonal methods of contraception (oral, injec... | A Single-Center, Clinical Study to Evaluate the Safety of a Non-Fragranced Personal Lubricant in Healthy Female Subjects | NCT02320227 | Entailment |
6,015 | 44 | A 48-year-old man comes to the office complaining of heartburn and acid reflux. He has taken over-the-counter antacids but sees no relief. Other medical history is unremarkable. The patient does not use tobacco, alcohol, or illicit drugs. Vital signs are within normal limits. BMI is 31 kg/m2. Physical examination... | I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old gu... | Inclusion Criteria:
- Adult candidates who are in overall good health but who suffer from the symptoms of
indigestion.
- Participants will be deemed to be in good health if they do not report any of the
existing medical conditions asked about in the screening questionna... | Upset Stomach Relief for Mild and Moderate Indigestion and Heartburn | NCT04153552 | Entailment |
3,906 | 30 | A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 chi... | I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 year... | Inclusion Criteria:
- Clinical
- 19-75 years of age (inclusive)
- Symptomatic OA (1 of the following: pain, stiffness, or swelling)
- Evidence of grade I, II or III OA on radiographic images according to
Kellgren-Lawrence grading scale.
... | A Study Comparing Viscosupplementation and Corticosteroid Injections for Knee Osteoarthritis | NCT01132677 | Entailment |
3,614 | 28 | A 23-year-old woman comes to the emergency department with a history of nosebleeds lasting for 1 hour. She has a history of heavy menses as well as occasional gum bleeding following dental procedures. Her mother also has a history of menorrhagia. Laboratory tests reveal increased bleeding time and slightly increased pa... | I had to rush to the ER because of a non-stop nosebleed that had been on for 1 hour. As a 23-year-old, I always had heavy periods, and sometimes, my gums would bleed after going to the dentist or brushing my teeth. I thought that it was not very alarming since my mom also had heavy periods. I did some lab tests that sh... | Inclusion Criteria:
- adults
- consultation during the early stages of care
- leaving after consultation
- agrees to participate in the study
Exclusion Criteria:
- minor patients
- permanently off care
- hospitalized patients
... | the Observance of Emergency Exit Treatments During the Stay of Care at the Exit of Reims Emergencies | NCT03836534 | Entailment |
2,930 | 21 | A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year. Over the last few months, he has also noticed weakness in the right upper extremity. BP is 120/75, PR is 80 and temperature is 37 C. Reflex... | I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rat... | Inclusion Criteria:
1. Patients ≥18 years and who have provided written informed consent to participate in
the study
2. Prior to trial entry patients will have a definite diagnosis of ALS according to El
Escorial Criteria. All patients will demonstrate either:
... | A Safety and Tolerability Study of ILB in Patients With Amyothrophic Lateral Sclerosis (ALS) | NCT03705390 | Entailment |
2,693 | 20 | A 49-year-old man comes to the office because of the bulging in his groin. Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases. His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications... | I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to... | Inclusion Criteria:
- Healthy males 18-80 years
- Primary inguinal unilateral hernia
Exclusion Criteria:
- Recurrent hernia
- Bilateral, scrotal or femoral hernia
- BMI above 35
Male
No healthy subjects accepted to join the trial.
Subject must be at l... | Effect of Suture for Mesh Fixation in Lichtenstein Hernia Repair | NCT00815698 | Entailment |
2,646 | 20 | A 49-year-old man comes to the office because of the bulging in his groin. Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases. His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications... | I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to... | Inclusion Criteria:
- Patients presenting for outpatient inguinal hernia repair without significant medical
comorbidities
- Patients who consent to participating and willing to wear device for designated time
period per protocol
Exclusion Criteria:
-... | Objective Measure of Recovery After Outpatient Surgery | NCT02616406 | Entailment |
2,468 | 16 | A 39-year-old woman comes to the clinic complaining of arthralgias and nodules on her legs. She has no fever or other skin rashes. The prior medical condition is unremarkable, and she takes no medications. On physical examination, there is moderate hepatomegaly. The lesions on her legs are tender and present predomin... | I'm just a 39-year-old young woman but lately I have noticed some underlying cysts on my legs and my joints were hurting so much. I don't have a fever. I don't have rashes. My medical history is totally clean and I don't take any medication. When I went to the clinic they did a physical examination where they found tha... | Inclusion Criteria:
- Subject is willing and able to give informed consent.
- Subject is willing and able to participate in the study as an outpatient and is
willing to comply with study requirements.
- Subject is 18 years of age or older.
- Subject has a dia... | Efficacy Study of Humira in the Treatment of Cutaneous Sarcoidosis | NCT00731757 | Entailment |
4,254 | 32 | A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia. The patient is sexually active with his wife and does not use any contraception methods. They have been trying to conceive for the past year with no success. The patient has a past medical history of recurrent p... | I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet ... | Major Inclusion Criteria: The following are major inclusion criteria:
1. A diagnosis of azoospermia after semen analysis.
2. Indication to proceed with testicular sperm extraction (TESE or microTESE) based on a
urologic evaluation.
3. Presence of round spermatids from testi... | Round Spermatid Injection Protocol | NCT04053309 | Entailment |
1,563 | 10 | A 19-year-old girl comes to the clinic due to a left wrist mass. She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns. Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient n... | I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penli... | Inclusion Criteria:
- Age > 18 Y.O.
- Have smoked Water-pipe at least once before.
Exclusion Criteria:
- Breast feeding Women.
- S/P Bacterial Or Viral infection, Last 2 weeks
- P.O. Steroids
- Water-pipe smoking, last 24 hours
... | Evaluation of the Acute Effect of Water-Pipe Smoking on the Respiratory System | NCT01157832 | Contradiction |
5,093 | 39 | A 55-year-old white woman comes for a routine checkup. She has no significant medical history and does not use tobacco, alcohol, or illicit drugs. The patient's only medication is an over-the-counter multivitamin. Family history is notable for a hip fracture in her mother. Blood pressure is 130/80 mm Hg and pulse i... | I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse w... | Inclusion Criteria:
- Ambulatory, postmenopausal women.
- A minimum of either one moderate or two mild atraumatic vertebral fractures, and a
minimum of seven evaluable nonfractured vertebrae.
- Hip BMD or lumbar spine BMD measurement at least 1.0 standard deviation (SD) ... | Effects of Teriparatide in the Treatment of Postmenopausal Women With Osteoporosis | NCT00670501 | Contradiction |
862 | 4 | A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes. The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief. Past medical history is notable for hypertension and hypercholesteremia. ... | I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tyl... | Inclusion criteria:
1. A history of knee joint pain for greater than 6 months.
2. Medial or lateral tibiofemoral joint line tenderness.
3. Unilateral knee pain 6/10 or greater, on average, on the visual analog scale (VAS),
that interferes with function most days per week.
... | Is Botox Effective in Relieving Pain From Knee Osteoarthritis? | NCT00279903 | Entailment |
4,396 | 33 | A 20-year-old man comes to the clinic for his routine checkup. The patient wears glasses for myopia and takes no medications. Vital signs are normal. On physical examination, the patient is tall with long upper extremities and fingers. The face appears narrow with down-slanted palpebral fissures, flattened malar bon... | I'm a 20-year-old guy, working as a driver and I went to the clinic for my routine checkup. I have myopia, so I wear glasses and I don't take any other medications. My vitals were normal. I also did a physical exam, and I was told that I have long legs, arms, and fingers. They also told me that my face is quite narrow,... | Inclusion Criteria:
- Is at least 17 years of age and has full legal capacity to volunteer;
- Has had a self-reported oculo-visual examination in the last two years;
- Has read, understood, and signed the information consent letter;
- Is willing and able to follow instruc... | Comparison of Somofilcon A Daily Disposable Test Contact Lens and Somofilcon A Daily Disposable Control Contact Lens | NCT03372551 | Entailment |
2,364 | 15 | An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity m... | I brought my 8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weak... | Inclusion Criteria:
- Parents/caregivers of youth between ages 6 and 17 with a primary diagnosis of Duchenne
muscular dystrophy (DMD) who lives at home .
- Access to a smart-phone or computer and internet for the weekly web-based sessions, as
well as uploading of the Ac... | Sleep Intervention in Young Boys With Duchenne Muscular Dystrophy | NCT04529707 | Entailment |
4,854 | 37 | A 47-year-old man comes to the office due to weight gain and fatigue. He is not able to lift heavy objects or climb stairs. Family history is positive for DM type 2 and HTN in his father. Blood pressure is 165/90 mm Hg and pulse is 85/min. On physical examination, there is symmetric proximal muscle weakness of the u... | I'm a 47-year-old man. I went to the clinic because I had been gaining weight and had increased fatigue over the past few weeks. I was not able to lift heavy objects or even climb the stairs. My dad was diagnosed with type 2 diabetes and high blood pressure. During the exam, they took my blood pressure, which was 165/9... | Inclusion Criteria:
- Patients with confirmed Cushing's syndrome [i.e. ectopic corticotropin syndrome,
adrenal adenoma, adrenal carcinoma, ACTH-Independent Macronodular Adrenal Hyperplasia
(AIMAH), or Primary Pigmented Nodular Adrenal Dysplasia (PPNAD)]
- For patients o... | Study of Efficacy and Safety of Osilodrostat in Cushing's Syndrome | NCT02468193 | Entailment |
2,604 | 20 | A 49-year-old man comes to the office because of the bulging in his groin. Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases. His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications... | I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to... | Inclusion Criteria:
- Patients undergoing elective primary unilateral open tension-free mesh inguinal hernia
repair
Exclusion Criteria:
- Inability to consent to the study
- BMI more than 40
- Skin infection near injection site
- Chronic ... | Comparison of TAP (Transversus Abdominis Plane) and Ilioinguinal/Iliohypogastric Nerve Block for Analgesia of Open Inguinal Herniorrhaphy | NCT01429480 | Contradiction |
1,484 | 9 | A 67-year-old woman comes to the clinic due to recent episode of choking, dysphagia, and cough. Her other medical problems include hypertension, dyslipidemia, and osteoarthritis. She does not smoke or use alcohol. She lives with her husband and she is able to do her own daily activities. She used to teach elementary ... | I'm a 67-year-old lady, and I went to the clinic due to nonstop choking, difficulty swallowing, and coughing. I also suffer from hypertension, cholesterol, and osteoarthritis. I do not smoke or drink alcohol. I live with my husband, and we are independent retired elementary school teachers. During the exam, my blood pr... | Inclusion Criteria:
- Pathological Group
- Must have dysphagia as diagnosed by a licensed and certified otolaryngologist,
gastroenterologist, or speech-language pathologist AND must have a dysphagia
treatment plan that includes one of the following primar... | Rehabilitation Manometry Study | NCT04130867 | Entailment |
178 | 1 | A 19-year-old male came to clinic with some sexual concern. He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates. On physical examination, there is some pubic hair and poo... | I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me sm... | Inclusion Criteria:
- Patients older than 18 years old and younger than 70 years.
- To have diagnosis of erectile dysfunction by IIEF. Qualification less than 46 points
and/or GAQ with Answer "NO".
- Patients with Inform consent letter signed.
- Patients with... | Treatment of Erectile Dysfunction in Hypogonadal Men With Testosterone Undecanoate | NCT00555087 | Entailment |
2,404 | 15 | An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity m... | I brought my 8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weak... | Inclusion Criteria:
- Patients with conclusive DMD diagnosis
- Written consent
- Able to perform physical exercise and answer questions
Exclusion Criteria:
- Lack of consent
- Cognitive disabled unable to answer questionnaire, understand instructions,... | Regular Physical Exercise in Duchenne Muscular Dystrophy | NCT03963453 | Entailment |
199 | 1 | A 19-year-old male came to clinic with some sexual concern. He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates. On physical examination, there is some pubic hair and poo... | I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me sm... | Inclusion Criteria:
- Male
- Age 18-65
- Morning serum testosterone (T) <300 ng/dL on two occasions
Exclusion Criteria:
- Significant intercurrent disease
- Abnormal prostate digital rectal exam, elevated PSA, AUA symptom score >15 or history
... | Study to Determine the Effect of Food on the Absorption of an Oral Testosterone Undecanoate Formulation | NCT00924612 | Entailment |
2,444 | 16 | A 39-year-old woman comes to the clinic complaining of arthralgias and nodules on her legs. She has no fever or other skin rashes. The prior medical condition is unremarkable, and she takes no medications. On physical examination, there is moderate hepatomegaly. The lesions on her legs are tender and present predomin... | I'm just a 39-year-old young woman but lately I have noticed some underlying cysts on my legs and my joints were hurting so much. I don't have a fever. I don't have rashes. My medical history is totally clean and I don't take any medication. When I went to the clinic they did a physical examination where they found tha... | Inclusion Criteria:
1. Subject is > 18 years of age.
2. Subject must have moderate to severe cutaneous sarcoidosis with chronic indurated
lesions (papules, nodules, and/or plaques), which histopathologically show
non-caseating granulomas with negative special stains for m... | A Study of Adalimumab to Treat Sarcoidosis of the Skin | NCT00274352 | Entailment |
2,432 | 16 | A 39-year-old woman comes to the clinic complaining of arthralgias and nodules on her legs. She has no fever or other skin rashes. The prior medical condition is unremarkable, and she takes no medications. On physical examination, there is moderate hepatomegaly. The lesions on her legs are tender and present predomin... | I'm just a 39-year-old young woman but lately I have noticed some underlying cysts on my legs and my joints were hurting so much. I don't have a fever. I don't have rashes. My medical history is totally clean and I don't take any medication. When I went to the clinic they did a physical examination where they found tha... | Inclusion Criteria:
- Clinical and radiologic suspicion of sarcoidosis stage I (mediastinal or hilar
lymphadenopathy) or stage II (lymphadenopathy and interparenchymal abnormalities)
- Indication for tissue verification of noncaseating granuloma's
- Provision of a writte... | EBUS vs EUS-B for Diagnosing Sarcoidosis | NCT02540694 | Contradiction |
6,160 | 46 | The patient is a 38-year-old man with cough and body ache that started 3 days ago. He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within n... | I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my tem... | Inclusion Criteria:
- Men and women over 18 and under 65.
- Household contact with a confirmed case of COVID-19 by PCR for Sars-CoV-2.
- Initiate study medication within 4 days from the last close contact with the index
case.
- The patient must not present sy... | Efficacy and Safety of Nitazoxanide for Post Exposure Prophylaxis of COVID-19 in Household Contacts | NCT04788407 | Contradiction |
4,403 | 34 | A 17-year-old male comes to the office due to several months of right elbow pain. The pain is worse with activity and limits his workouts and activities. He has tried over-the-counter medications with limited relief. Medical history is notable for eczema, and current medications include a topical hydrocortisone oint... | I'm 17, and I had to go to the doctor because I've been suffering from my right elbow for several months. The pain is even worse when I do sports and it kind of limits me for my workouts and activities. I tried over-the-counter medications but it didn't work much. I had eczema before and my medication is ointments that... | Inclusion Criteria:
- Must have pain at lateral elbow (lateral epicondylitis) for at least six months
- Pain must not come from trauma
- Painful palpation of the lateral epicondyle
- At least one out of two positive test: Cozen's, Mill's
Exclusion Criteria:
... | Does Adding Cryostimulation to Conservative Care Help in Managing Chronic Lateral Epicondylitis? a Pilote Study | NCT02308514 | Contradiction |
6,949 | 50 | A 70-year-old man comes to the office accompanied by his wife. The patient has experienced progressive memory loss over the last years. He needs help with some of his routine activities, such as paying bills. The patient's wife says, "He used to be such an independent person, but now he needs help with many things, ... | I am a 70-year-old man, and I paid a visit to the doctor with my wife the other day. I noticed that I tend to forget small things and that my memory has decreased over the past few years. I even ask my wife to help me out with my daily routine. I used to be the one paying the bills, but now she has to give me a hand. M... | Key Inclusion Criteria:
- Age 55 to 85 years
- Mild-to-moderate AD dementia subjects, MMSE 14-24, CDR 1 or 2 at the Screening visit
- Clinical diagnosis of dementia, due probably to AD, by Revised National Institute on
Aging-Alzheimer's Association criteria (McKhann, 201... | A Translational Study of ATH-1017 in Mild to Moderate Alzheimer's Disease | NCT04491006 | Entailment |
1,749 | 11 | A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that show... | I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and m... | Inclusion Criteria:
1. histologically or cytologically confirmed diagnosis of gastric adenocarcinoma or
gastroesophageal junction adenoca (i.e. an adenocarcinoma with > 50% extension in the
stomach)
2. patients must present with stage IV disease not amenable to surgery, r... | Trial of XP (Capecitabine/CDDP) Simvastatin in Advanced Gastric Cancer Patients | NCT01099085 | Contradiction |
851 | 4 | A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes. The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief. Past medical history is notable for hypertension and hypercholesteremia. ... | I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tyl... | Inclusion Criteria:
Or at least two of criteria 2-6 established by the American College of Rheumatology (ACR):
1. Kellgren and Lawrence (K/L) grade ≥II
2. morning stiffness <30 min in duration
3. crepitus on movement of the knee joint
4. bony tenderness at the knee j... | The Effects of Joint Effusion on Proprioception | NCT01060215 | Entailment |
6,690 | 48 | A 20-year-old man comes to the emergency due to bleeding after a tooth extraction. The bleeding has persisted for approximately 30 minutes despite constant direct pressure. He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family histo... | I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove... | Inclusion Criteria:
- Patients diagnosed with hemophilia A and B
- Patients adults (over 18 years)
- Patients diagnosed with hemophilic arthropathy of the elbow (by clinical assessment
with the Hemophilia Joint Health Score)
- Patients pn prophylactic treatme... | Fascial Therapy in Elbow Hemophilic Arthropathy | NCT03009591 | Contradiction |
4,361 | 33 | A 20-year-old man comes to the clinic for his routine checkup. The patient wears glasses for myopia and takes no medications. Vital signs are normal. On physical examination, the patient is tall with long upper extremities and fingers. The face appears narrow with down-slanted palpebral fissures, flattened malar bon... | I'm a 20-year-old guy, working as a driver and I went to the clinic for my routine checkup. I have myopia, so I wear glasses and I don't take any other medications. My vitals were normal. I also did a physical exam, and I was told that I have long legs, arms, and fingers. They also told me that my face is quite narrow,... | Myopic volunteers, ages 20 to 35, who had not worn contact lenses were eligible to
participate in the study if they were free of ocular disease, were in good physical health,
and were not taking systemic medications that could have ocular side effects. In addition,
eligibility was limited to per... | The Berkeley Orthokeratology Study | NCT00000123 | Entailment |
227 | 2 | A 32-year-old woman comes to the hospital with vaginal spotting. Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with ... | I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing... | Inclusion Criteria:
1. Age: between 35 and 40 years of age,
2. Physiological menstrual cycles (24-35 day cycle),
3. Normal endocrine function (normal PRL and TSH, FSH ≤ 15 IU / ml),
4. Transvaginal ultrasound (TVS) without pathological findings,
5. Free personal me... | Low-dose HCG as an Adjunct to Ovarian Stimulation in Subfertile Women Undergoing ART | NCT03423537 | Contradiction |
2,130 | 13 | A 24-year-old man comes to the office complaining of infertility. He and his wife have been trying to conceive for the last 18 months. Medical records of his wife showed no abnormalities. The patient doesn't smoke and takes no medications. Height is 185 cm and weight is 77 kg. Heart and lung sounds are normal. Th... | I'm only a 24 year old man but I’m already struggling with infertility. I went to a clinic with my wife the other day because we've been trying to have a baby for at least 18 months. The medical records of my wife are totally normal. For me I don't smoke or take any medication. I'm 185 cm and 77 kg. Everything was norm... | Inclusion Criteria:
- Ability to produce semen sample
Exclusion Criteria:
- Cognitive impairment
- Inadequate language skills for informed consent
Male
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 60 Years | Modern Analyses of the Semen in Evaluating Male Fertility and Treatment Options of Male Infertility | NCT02932865 | Entailment |
6,198 | 46 | The patient is a 38-year-old man with cough and body ache that started 3 days ago. He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within n... | I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my tem... | Inclusion Criteria:
- Patients with IBD +/- flare +/- COVID 19 positivity
Exclusion Criteria:
- Patients below 16
- Patient with inactive IBD
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 16 Years old.
Subject must be... | PREPARE-IBD: Physician Responses to Disease Flares and Patient Adaptation in Relation to Events in Inflammatory Bowel Disease During COVID-19 Pandemic | NCT04410484 | Contradiction |
249 | 2 | A 32-year-old woman comes to the hospital with vaginal spotting. Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with ... | I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing... | Inclusion Criteria:
1. Subject is informed and has been given ample time and opportunity to think about
his/her participation and has given his/her written informed consent
2. Subject is ≥18 years of age
3. Subject's health status: individual is considered to be healthy (hy... | A Single Center Study to Demonstrate the Safety and Performance of Lifelight® First Software Application | NCT03998098 | Contradiction |
1,683 | 10 | A 19-year-old girl comes to the clinic due to a left wrist mass. She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns. Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient n... | I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penli... | Inclusion Criteria:
- above 12 years old
Exclusion Criteria:
- unclear Korotkoff sounds
- wrist circumference outside of the designated range (13.5-23 cm)
- arrhythmias
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be... | Validation of Wrist Type Oscillometric Blood Pressure Monitorings | NCT04633785 | Entailment |
1,968 | 11 | A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that show... | I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and m... | Inclusion Criteria:
- Patients who have the indication for upper gastrointestinal endoscopy
Exclusion Criteria:
- Cannot be in prone position
- The endoscopist deny the assigned position in any reason.
No condition on gender to be admitted to the trial.
No healthy subjects a... | Position of EGD in Droplet Spreading | NCT04329013 | Entailment |
2,118 | 13 | A 24-year-old man comes to the office complaining of infertility. He and his wife have been trying to conceive for the last 18 months. Medical records of his wife showed no abnormalities. The patient doesn't smoke and takes no medications. Height is 185 cm and weight is 77 kg. Heart and lung sounds are normal. Th... | I'm only a 24 year old man but I’m already struggling with infertility. I went to a clinic with my wife the other day because we've been trying to have a baby for at least 18 months. The medical records of my wife are totally normal. For me I don't smoke or take any medication. I'm 185 cm and 77 kg. Everything was norm... | Inclusion Criteria:
- Participant must have a body mass index (BMI; weight in kg divided by the square of
height in meters) between 18.0 and 30.0 kilogram per square meter kg/m^2, extremes
included, and a body weight not less than 50.0 kg, extremes included
- Participan... | A Study to Assess the Relative Bioavailability of JNJ64041575 Administered as 2 Different New Concept Formulations (Oral Suspension and Tablet) Compared to Their Respective Current Formulations, and to Assess the Effect of Food on the Pharmacokinetics of the 2 New Concept Formulations | NCT03010059 | Contradiction |
3,430 | 25 | A 50-year-old woman comes to the clinic with intermittent ear discharge and sense of hearing loss on her left ear. Past medical history is significant for obesity, hyperlipidemia, and diabetes mellitus. Her medications include Metformin, Atorvastatin and Vit D supplement. Vital signs are normal. BMI is 37. Otoscopy s... | I went to the clinic the other day because I had some fluid in my ear and I felt like I could not hear as well as I used to in my left ear. I'm a 50-year-old woman, and I have been obese for a while now. I have diabetes and cholesterol. I take some medication. I take metformin, atorvastatin, and vitamin D supplements. ... | Inclusion Criteria:
1. Male and female subjects between the ages of 18 to 55.
2. BMI between 30 to 50 kg/m2. Subjects with BMI ≥ 35 to 50 kg/m2 inclusive, and subjects
with a BMI of 30.0 to 34.9 kg/m2 are required to have one or more of the following
obesity-related co-mo... | A Study of the TransPyloric Shuttle™ (TPS™) for Weight Reduction in Obese Subjects | NCT01386905 | Entailment |
3,930 | 30 | A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 chi... | I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 year... | Inclusion Criteria:
- Participants who have suffered from knee osteoarthritis at least for one year and meet
the criteria of American College of Rheumatology
- Participants who are taking stable dose of meloxicam 7.5 milligram (mg) or 15 mg daily
or aceclofenac 100 mg t... | A Comparative Study of Tramadol Hydrochloride Plus Acetaminophen Tablets Maintenance Versus Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) Maintenance in Participants With Knee Osteoarthritis | NCT00635349 | Entailment |
2,713 | 20 | A 49-year-old man comes to the office because of the bulging in his groin. Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases. His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications... | I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to... | Inclusion Criteria:
- Male
- Age 30-70 years referred to hospital with a primary inguinal hernia.
Exclusion Criteria:
- Recurrent hernia
- Scrotal or bilateral hernia
- Previous lower abdominal surgery
- Unable to participate in follow up
... | Randomized Multicentre Study Comparing TEP With Lichtenstein Repair for Primary Inguinal Hernia | NCT00568269 | Entailment |
1,546 | 10 | A 19-year-old girl comes to the clinic due to a left wrist mass. She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns. Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient n... | I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penli... | Inclusion Criteria:
Inclusion criteria for the adolescent include:
- age between 13- to 17-years, inclusive
- resident of one of the three parishes in and around Kingston, Jamaica (the study area)
- plan to reside in the "study area" for the next 12 months
- able... | Development and Testing of a Jamaican Mother-daughter HIV Risk-reduction Program | NCT03411577 | Contradiction |
6,312 | 46 | The patient is a 38-year-old man with cough and body ache that started 3 days ago. He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within n... | I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my tem... | Inclusion Criteria:
1. Written documentation of SARS-CoV-2 infection confirmed by a validated test.
2. Presence of greater than or equal to ≥1 of the following COVID-19-related symptoms
indicating mild disease: fever (temperature ≥100.4), anosmia (loss of taste or smell),
... | A Study of LAM-002A for the Prevention of Progression of COVID-19 | NCT04446377 | Entailment |
2,839 | 21 | A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year. Over the last few months, he has also noticed weakness in the right upper extremity. BP is 120/75, PR is 80 and temperature is 37 C. Reflex... | I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rat... | Inclusion Criteria:
- aged 18 years and older
- patients diagnosed with amyotrophic lateral sclerosis or other neurodegenerative
disease, and healthy controls
Exclusion Criteria:
- Subjects with acute bacterial infection of the GI tract
- Subjects on... | Establishment of a Human Tissue Bank for Studying the Microbial Etiology of Neurodegenerative Diseases | NCT01954875 | Entailment |
5,429 | 40 | A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction. Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration. The patient has heavy menstrual cycles each month. She has no other medical problems and takes no medications... | I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical c... | Inclusion Criteria:
- Women aged 18-50 years having regular menstrual cycles
- Women willing to collect all sanitary protection for 6 cycles
- Women with no contraindications to use of combined hormonal contraception
- Women not using any hormonal contraception or any tre... | A New Treatment Option for Heavy Menstrual Bleeding | NCT01715025 | Entailment |
335 | 2 | A 32-year-old woman comes to the hospital with vaginal spotting. Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with ... | I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing... | Inclusion Criteria:
- Women post-menopausal with abnormal uterine bleeding, ultrasound with thick
endometrial distorted
Exclusion Criteria:
- Women with uterine malformations
- Women with mental retardation
- Women underwent pelvic radiotherapy
Femal... | Clinical Trial of Hysteroscopy in Postmenopausal Women to Compare Techniques | NCT01376934 | Contradiction |
4,477 | 34 | A 17-year-old male comes to the office due to several months of right elbow pain. The pain is worse with activity and limits his workouts and activities. He has tried over-the-counter medications with limited relief. Medical history is notable for eczema, and current medications include a topical hydrocortisone oint... | I'm 17, and I had to go to the doctor because I've been suffering from my right elbow for several months. The pain is even worse when I do sports and it kind of limits me for my workouts and activities. I tried over-the-counter medications but it didn't work much. I had eczema before and my medication is ointments that... | Individuals who meet all of the following criteria are eligible for enrollment into the
study:
Inclusion Criteria:
- Adult between 18-45 years of age
- Pain over the lateral humeral epicondyle provoked by at least two of the following:
gripping, palpation, stretchin... | Clinical and Ultrasonographic Results of Intratissue Percutaneous Electrolysis in Lateral Epicondylitis | NCT02085928 | Entailment |
5,230 | 39 | A 55-year-old white woman comes for a routine checkup. She has no significant medical history and does not use tobacco, alcohol, or illicit drugs. The patient's only medication is an over-the-counter multivitamin. Family history is notable for a hip fracture in her mother. Blood pressure is 130/80 mm Hg and pulse i... | I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse w... | Inclusion Criteria:
- 20 to 79 residents in urban Beijing, China.
Exclusion Criteria:
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 20 Years old.
Subject must be at most 79 Years | Prevalence and Predictors of Osteoporosis in the Beijing's Urban Population | NCT01476150 | Entailment |
5,347 | 40 | A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction. Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration. The patient has heavy menstrual cycles each month. She has no other medical problems and takes no medications... | I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical c... | Inclusion Criteria:
- Female at least 30 years of age who is premenopausal and for whom childbearing is
complete.
- Excessive menstrual bleeding documented by a diary score of at least 150.
- Have documented 3 months failed medical therapy or either a) contraindicated fo... | Uterine Balloon Treatment for Heavy Period Bleeding. | NCT00215618 | Contradiction |
4,168 | 32 | A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia. The patient is sexually active with his wife and does not use any contraception methods. They have been trying to conceive for the past year with no success. The patient has a past medical history of recurrent p... | I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet ... | Inclusion Criteria:
General and Demographic Criteria:
- Age of 18 to 40 years
- Access to a participating HVTN clinical research site (CRS) and willingness to be
followed for the planned duration of the study
- Ability and willingness to provide informed consent... | Evaluating the Safety and Immunogenicity of ALVAC-HIV and MF59®- or AS01B-adjuvanted Bivalent Subtype C gp120 in Healthy, HIV-uninfected Adult Participants | NCT03122223 | Contradiction |
5,713 | 42 | A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively. On physical examination, the patient's height is in the 5th percentile of her age. Other findings include low-set ears, a high arched palate... | I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a we... | Inclusion Criteria:
- short stature children aged 2 years or more
- children with GHD,TS, CRF, SGA or ISS
- written informed consent from the person, person's parent or legal guardian
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
... | Long-term Safety and Effectiveness of Growth Hormone With GHD, TS, CRF, SGA , ISS and PWS in Children | NCT01604395 | Entailment |
1,407 | 9 | A 67-year-old woman comes to the clinic due to recent episode of choking, dysphagia, and cough. Her other medical problems include hypertension, dyslipidemia, and osteoarthritis. She does not smoke or use alcohol. She lives with her husband and she is able to do her own daily activities. She used to teach elementary ... | I'm a 67-year-old lady, and I went to the clinic due to nonstop choking, difficulty swallowing, and coughing. I also suffer from hypertension, cholesterol, and osteoarthritis. I do not smoke or drink alcohol. I live with my husband, and we are independent retired elementary school teachers. During the exam, my blood pr... | Inclusion Criteria
1. Sex: Male and Female; similar proportion of each preferred.
2. Age: At least 18 years.
3. Weight: BMI (Body Mass Index) less than or equal to 30.
4. Qualifying subjects must be in good health and physical condition as determined by
medical h... | Dexmethylphenidate Hydrochloride Tablets Under Non-Fasting Conditions | NCT00829673 | Contradiction |
8 | 1 | A 19-year-old male came to clinic with some sexual concern. He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates. On physical examination, there is some pubic hair and poo... | I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me sm... | Inclusion Criteria:
- Healthy males between 18 and 50 years of age.
- Ambulatory, physically active, but not in competitive sports.
- Eugonadal: Normal Serum Testosterone (300-1100 nmol/L).
- Normal LH
- Normal FSH
- Able and willing to comply with... | The Role of 5-alpha Reductase in Mediating Testosterone Actions | NCT00493987 | Contradiction |
6,770 | 48 | A 20-year-old man comes to the emergency due to bleeding after a tooth extraction. The bleeding has persisted for approximately 30 minutes despite constant direct pressure. He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family histo... | I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove... | Inclusion Criteria:
- Male patients
- Severe Hemophilia A (FVIII:C <1%)
- No previous treatment with FVIII concentrates or other blood products containing FVIII
Exclusion Criteria:
- Diagnosis with a coagulation disorder other than Hemophilia A
- Seve... | Human Cell Line-derived Recombinant Factor VIII (Human-cl-rhFVIII) in Previously Untreated Patients | NCT01712438 | Entailment |
6,348 | 46 | The patient is a 38-year-old man with cough and body ache that started 3 days ago. He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within n... | I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my tem... | Inclusion Criteria:
- Confirmed diagnosis of COVID-19 disease.
Exclusion Criteria:
- The patients were excluded patients <18 years age and without confirmed diagnosis of
disease.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be ... | Role of Lymphocyte Subsets and Laboratory Measurements in COVID-19 Disease | NCT04779359 | Entailment |
4,245 | 32 | A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia. The patient is sexually active with his wife and does not use any contraception methods. They have been trying to conceive for the past year with no success. The patient has a past medical history of recurrent p... | I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet ... | Inclusion Criteria:
- Non-smoking, male or female, age ≥18 years and ≤55 years old at the time of informed
consent (note: to be considered non-smokers, participants must have discontinued
smoking for at least 4 weeks before dosing)
- Body mass index (BMI) ≥18 and <32 ki... | Study to Assess the Safety, Tolerability, and Pharmacokinetics of E2730 | NCT03054194 | Entailment |
2,194 | 14 | A 39-year-old man comes to the emergency department with an acute onset of severe left toe pain. The toe is red and exhibits swelling. The patient is not febrile, and does not remember any recent trauma. Medical history is not significant except for the similar attacks and the diagnosis of gouty arthritis. His medicat... | I'm a 39-year-old man and got admitted to the ER after an unbearable pain in my left toe. My toe was red and terribly swollen. I was still standing on my feet, not febrile and I don't remember hitting my head or anything. I don't have any special medical history, but I had been diagnosed with gout before. I take Lopuri... | Inclusion Criteria:
1. Adult (age 21-75 inclusive) men and women of non child bearing potential with
established or symptomatic gout which is defined as having at least ONE of any of the
3 following factors:
1. ≥ 1 tophus
2. 1 gout flare within the la... | Multi-Dose Safety/Pharmacodynamic Study of SEL-212/SEL-037 in Subjects With Symptomatic Gout & Elevated Blood Uric Acid | NCT02959918 | Contradiction |
6,535 | 48 | A 20-year-old man comes to the emergency due to bleeding after a tooth extraction. The bleeding has persisted for approximately 30 minutes despite constant direct pressure. He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family histo... | I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove... | Inclusion Criteria
-Adult subjects who participated in prior intrahepatic AAV2-hFIX16 gene transfer studies
Exclusion Criteria
- Subjects who will not consent for study
- Subjects who the investigators believe are not capable of performing endpoints of the
study
Ma... | LTFU for Gene Transfer Subjects With Hemophilia B | NCT00515710 | Contradiction |
748 | 4 | A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes. The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief. Past medical history is notable for hypertension and hypercholesteremia. ... | I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tyl... | Inclusion Criteria: • 40-60 years of age paients will be included in this study
- BMI (25.1±4.2) kg/m2
- Subjects with stiffness and knee pain
- Subjects with objection of pain in knee joint that was aggravated by performing 2 or
more of the following functional activiti... | Effect of Biomechanical Correction in Medial Tibiofemoral Joint Osteoarthritis | NCT04324931 | Contradiction |
4,711 | 35 | A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles. The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days. She is sexually active with her husband and... | I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of ... | Inclusion Criteria:
1. 18 years of age or older with a history of receptive vaginal intercourse.
2. HIV negative by EIA within 28 days of enrollment.
3. Understand and agree to local STI reporting requirements.
4. Able and willing to provide written informed consent to take p... | PK/PD of Single Dose Dapivirine Vaginal Film | NCT01924091 | Entailment |
5,276 | 39 | A 55-year-old white woman comes for a routine checkup. She has no significant medical history and does not use tobacco, alcohol, or illicit drugs. The patient's only medication is an over-the-counter multivitamin. Family history is notable for a hip fracture in her mother. Blood pressure is 130/80 mm Hg and pulse i... | I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse w... | Inclusion Criteria:
For inclusion in the study, subjects must fulfil the following criteria:
1. Willing and able to give written informed consent for participation in the study.
2. Healthy women in early post-menopausal phase (at least two [2] years but a maximum of
12 years ... | Efficacy of a Probiotic Product on Bone Mineral Density (BMD) in Healthy Women in Early Post-menopausal Phase | NCT02722980 | Entailment |
1,959 | 11 | A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that show... | I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and m... | - INCLUSION CRITERIA:
- Patients must have histologically or cytologically confirmed gastric adenocarcinoma or
gastroesophageal junction (Siewert I-III) adenocarcinoma confirmed by the Laboratory
of Pathology, NCI
- Must have received systemic chemotherapy, minimum 3 m... | Heated Intraperitoneal Chemotherapy and Gastrectomy for Gastric Cancer With Positive Peritoneal Cytology | NCT03092518 | Entailment |
253 | 2 | A 32-year-old woman comes to the hospital with vaginal spotting. Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with ... | I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing... | Inclusion Criteria:
- Infertile women who were indicated for IUI cycles
- bilateral tubal patency
- at least one follicle ≥ 18mm in diameter on the day of trigger, and
- men with more than five millions total motile sperm after preparation.
- Only the first cy... | GnRH Agonist Versus hCG Trigger in Ovulation Induction With Intrauterine Insemination. | NCT03825445 | Contradiction |
3,211 | 23 | A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn. The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness. She also reports occasional joint pain. Medical history... | I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to t... | Inclusion Criteria:
- Weighs at least 40 kg (88.2 lbs)
- Meets European criteria proposed by the American-European Consensus Group for primary
Sjogren's syndrome
- Has 1 or more of the following symptoms of Sjogren's syndrome: fatigue; joint pain;
peripheral... | Anti-CD20 Antibody Therapy for Sjogren's Syndrome | NCT00101829 | Entailment |
6,872 | 50 | A 70-year-old man comes to the office accompanied by his wife. The patient has experienced progressive memory loss over the last years. He needs help with some of his routine activities, such as paying bills. The patient's wife says, "He used to be such an independent person, but now he needs help with many things, ... | I am a 70-year-old man, and I paid a visit to the doctor with my wife the other day. I noticed that I tend to forget small things and that my memory has decreased over the past few years. I even ask my wife to help me out with my daily routine. I used to be the one paying the bills, but now she has to give me a hand. M... | Exclusion criteria for AD will be:
- frontotemporal dementia;
- behavioural variant of frontotemporal dementia;
- vascular dementia;
- extra-pyramidal syndromes;
- reversible dementias (including pseudodementia of depression);
- Lewy body dementia.... | Sustainable Method for Alzheimer's Prediction | NCT03654911 | Contradiction |
4,140 | 32 | A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia. The patient is sexually active with his wife and does not use any contraception methods. They have been trying to conceive for the past year with no success. The patient has a past medical history of recurrent p... | I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet ... | Inclusion Criteria:
1. Patients who have provided written informed consent for participation in this study
2. Male and female patients aged at least 40 years at the time of enrolment who are given
diagnosis of COPD by a physician*1
3. Patients whose respiratory function tes... | The Study for Evaluating Factors Relating to Daily Step Counts and Physical Activity in Japanese Patients With COPD. | NCT03642613 | Contradiction |
501 | 2 | A 32-year-old woman comes to the hospital with vaginal spotting. Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with ... | I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing... | Inclusion Criteria:
1. Between 18-40 years of age at the time of study initiation; 1.1 Enrollment will be
targeted for 225 subjects aged 18-35 (for safety and effectiveness analyses) and an
additional 25 subjects aged 36-40 (for safety only) (note: all subjects will be
... | Evaluation of the Efficacy and Safety of LevoCept | NCT02882191 | Contradiction |
518 | 2 | A 32-year-old woman comes to the hospital with vaginal spotting. Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with ... | I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing... | Inclusion Criteria:
- Patients with unexplained infertility
- Age between 18 - 37 years
- Period of infertility > 1 year
- Patent Fallopian tubes detected by hysterosalpingography and/or laparoscopy
- Normal basal luteinizing hormone (LH), follicle stimulating... | Extended Letrozole Regimen Versus Clomiphene Citrate for Superovulation in Patients With Unexplained Infertility Undergoing Intrauterine Insemination | NCT01232075 | Contradiction |
4,433 | 34 | A 17-year-old male comes to the office due to several months of right elbow pain. The pain is worse with activity and limits his workouts and activities. He has tried over-the-counter medications with limited relief. Medical history is notable for eczema, and current medications include a topical hydrocortisone oint... | I'm 17, and I had to go to the doctor because I've been suffering from my right elbow for several months. The pain is even worse when I do sports and it kind of limits me for my workouts and activities. I tried over-the-counter medications but it didn't work much. I had eczema before and my medication is ointments that... | Inclusion Criteria:
- Subjects with clinical diagnosis of tennis elbow within the last 3 months
- Subjects both male and female, aged 18-60 years (both inclusive)
- Subjects who are willing to give informed consent and adhere to the study protocol
Exclusion Criteria:
... | A Study to Determine Safety & Efficacy of Autologous Human Platelet Lysate in Lateral Epicondylitis (Tennis Elbow) | NCT01668862 | Contradiction |
6,671 | 48 | A 20-year-old man comes to the emergency due to bleeding after a tooth extraction. The bleeding has persisted for approximately 30 minutes despite constant direct pressure. He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family histo... | I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove... | Inclusion Criteria:
PTPs:
- Males of any age who have been diagnosed with severe congenital hemophilia A (FVIII
activity levels < 1%) and who participated in a previous CSL-sponsored clinical study
with rVIII-SingleChain.
- Males 0 to <65 years age who have bee... | An Open-label Safety and Efficacy Study of Recombinant FVIII in Patients With Severe Hemophilia A | NCT02172950 | Contradiction |
900 | 4 | A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes. The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief. Past medical history is notable for hypertension and hypercholesteremia. ... | I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tyl... | Inclusion Criteria:
- Ambulatory (able to walk unassisted, the use of a crutch or a walking stick (only one)
is allowed if already used at screening but should be avoided during the study up to
the 6-month follow-up visit)
- Diagnosed with primary knee OA, fulfilling th... | Phase III Study on the Safety and Efficacy of a Single Intra-articular Administration of JTA-004 in Symptomatic Knee Osteoarthritis | NCT04333160 | Entailment |
1,709 | 10 | A 19-year-old girl comes to the clinic due to a left wrist mass. She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns. Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient n... | I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penli... | 1. Men and women, aged 18 to 50 years. Women of non-childbearing potential may be
included.
2. Body mass index in the range of 18 to 30 kg/meter squared and body weight equal to or
greater than 50 kg.
3. Healthy as determined by the investigator on the basis of medical hi... | Study Evaluating the Pharmacokinetics of the Potential Drug Interaction Between CYP2C9 Inhibitor and Substrate | NCT00369304 | Entailment |
3,072 | 22 | A 15-year-old boy with mild intellectual disability is brought to the office by his parents for a routine physical examination. The boy is going to a school for students with learning disabilities. The patient was adopted, and his immunizations are up to date. Review of the patient's medical records is notable for c... | My husband and I brought our 15-year-old son to the clinic for his routine exam. My son is going to school for special needs students. We adopted him a few years ago. His vaccinations are up to date. He already passed some chromosome testing and they found that he has a fragile X syndrome. The doctor told us that it co... | Inclusion Criteria:
- Subject has previously been identified through molecular testing at Esoterix Genetic
Laboratories as a Fragile X intermediate, premutation (carrier) or full mutation
(affected).
- In the opinion of the subject's physician, the subject is medically ... | Validation of Saliva in the Esoterix Genetic Laboratories Fragile X Assay | NCT01616589 | Entailment |
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