id int64 3 7.01k | topic_id int64 1 50 | statement_medical stringclasses 50
values | statement_pol stringclasses 50
values | premise stringlengths 111 17k | NCT_title stringlengths 18 299 | NCT_id stringlengths 11 11 | label stringclasses 2
values |
|---|---|---|---|---|---|---|---|
4,138 | 32 | A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia. The patient is sexually active with his wife and does not use any contraception methods. They have been trying to conceive for the past year with no success. The patient has a past medical history of recurrent p... | I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet ... | Inclusion Criteria:
- Non-smokers (<10 pack year history and no active smoking in the past year);
- Diagnosis of cystic fibrosis via standard sweat chloride/phenotypic
features/genotyping
- Able to reproducibly perform lung function testing and have an FEV1 >30% of predi... | 19F MRI of Ventilation in Subjects With Cystic Fibrosis Undergoing Treatment for Pulmonary Exacerbation | NCT03497117 | Contradiction |
1,991 | 11 | A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that show... | I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and m... | DISEASE CHARACTERISTICS:
- Histologically confirmed gastric adenocarcinoma, including type II or type III
adenocarcinoma of the esophagogastric junction
- Stage III disease
- T3 or T4 and/or N2
- No stage IV disease
... | S-1 and Cisplatin in Treating Patients Who Are Undergoing Surgery for Stage III Stomach Cancer | NCT00182611 | Entailment |
6,516 | 48 | A 20-year-old man comes to the emergency due to bleeding after a tooth extraction. The bleeding has persisted for approximately 30 minutes despite constant direct pressure. He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family histo... | I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove... | Inclusion Criteria:
1. Subjects must have participated in the "GreenGene™ F_P3", (with Eudra CT number
2012-001445-40) or a pediatric study with GreenGene™ F
2. Have ≥50 previous exposure days to GreenGene™ F, as documented in the subject's
medical records.
3. ... | Safety and Efficacy Extension Study of GreenGene™ F in Previously Treated Patients Diagnosed With Severe Hemophilia A | NCT02027779 | Contradiction |
2,022 | 11 | A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that show... | I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and m... | - INCLUSION CRITERIA:
Initial Enrollment:
-An individual who harbors a pathogenic, or likely pathogenic, CDH1 germline variant.
Note: individuals with CDH1 variant classified as any of the following are not eligible:
- variant of uncertain significance
- benign
... | Phase II Randomized Trial of Bethesda Protocol Compared to Cambridge Method for Detection of Early Stage Gastric Cancer in CDH1 Mutation Carriers | NCT04535414 | Entailment |
2,908 | 21 | A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year. Over the last few months, he has also noticed weakness in the right upper extremity. BP is 120/75, PR is 80 and temperature is 37 C. Reflex... | I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rat... | Inclusion Criteria:
- A clinical diagnosis of possible, laboratory-supported probable, probable or definite
ALS, according to modified EL Escorial criteria
- FVC greater or equal to 60% at the screening visit
- Symptom onset within 5 years
- 21 to 85 years of... | Combination Therapy Selection Trial in Amyotrophic Lateral Sclerosis | NCT00355576 | Entailment |
2,141 | 14 | A 39-year-old man comes to the emergency department with an acute onset of severe left toe pain. The toe is red and exhibits swelling. The patient is not febrile, and does not remember any recent trauma. Medical history is not significant except for the similar attacks and the diagnosis of gouty arthritis. His medicat... | I'm a 39-year-old man and got admitted to the ER after an unbearable pain in my left toe. My toe was red and terribly swollen. I was still standing on my feet, not febrile and I don't remember hitting my head or anything. I don't have any special medical history, but I had been diagnosed with gout before. I take Lopuri... | Inclusion Criteria:
- Subject is able to understand the study procedures, the risks involved and willing to
provide written informed consent before the first study related activity.
- Subject meets the diagnosis of gout as per the American Rheumatism Association
Criteri... | Combining Lesinurad With Allopurinol in Inadequate Responders | NCT01510158 | Contradiction |
1,555 | 10 | A 19-year-old girl comes to the clinic due to a left wrist mass. She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns. Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient n... | I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penli... | Inclusion criteria:
- Age ≥ 18 years
- No significant non-invasive systolic blood pressure difference between left arm and
right arm (difference <20mmHg in systolic arterial pressure)
- Patient requires continuous monitoring of diastolic and systolic blood pressure
... | Validation of the Aktiia SA PulseWatch OBPM Device at the Wrist Against Invasive Blood Pressure Measurements | NCT03837769 | Contradiction |
2,418 | 15 | An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity m... | I brought my 8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weak... | Inclusion Criteria:
- Completion of blinded study drug treatment in the previous Phase 2b study
(PTC124-GD-007-DMD).
- Ability to provide written informed consent (parental/guardian consent if
applicable)/assent (if less than [<]18 years of age).
- In partic... | Phase 2B Extension Study of Ataluren (PTC124) in Duchenne/Becker Muscular Dystrophy (DMD/BMD) | NCT00847379 | Entailment |
1,977 | 11 | A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that show... | I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and m... | Inclusion Criteria:
patients scheduled to upper digestive endoscopy for diagnostic purposes due to complaints
of epigastric burning.
Exclusion Criteria:
American Society of Anesthesiologists (ASA) score above II, diabetes mellitus, pregnancy,
renal or hepatic failure, gastroes... | Residual Gastric Volume After the Ingestion of a Beverage Containing Carbohydrates Plus Whey Protein | NCT01828645 | Entailment |
114 | 1 | A 19-year-old male came to clinic with some sexual concern. He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates. On physical examination, there is some pubic hair and poo... | I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me sm... | Inclusion Criteria for first group:
1. Patients with testosterone deficiency (total testosterone< 277 ng/dL [9.6 nmol/L])
measured between 7-10 am, and with one or more symptoms and signs suggestive of
androgen deficiency as mainly determined by history.
- Reduced s... | Autonomic Manifestations of Testosterone Deficiency in Men | NCT02715713 | Contradiction |
4,432 | 34 | A 17-year-old male comes to the office due to several months of right elbow pain. The pain is worse with activity and limits his workouts and activities. He has tried over-the-counter medications with limited relief. Medical history is notable for eczema, and current medications include a topical hydrocortisone oint... | I'm 17, and I had to go to the doctor because I've been suffering from my right elbow for several months. The pain is even worse when I do sports and it kind of limits me for my workouts and activities. I tried over-the-counter medications but it didn't work much. I had eczema before and my medication is ointments that... | Inclusion Criteria:
- males >18 yr and < 70 yr
- BMI < 38
- chronic lateral epicondylitis (symptomatic > 3 mo)
- pain on provocation >/- 4 on 11 point scale
Exclusion Criteria:
- patients on other pain medications
- bilateral elbow pain
... | Phase II Dose-Ranging Study of OrthoDerm Patch for Patients With Tennis Elbow | NCT00447928 | Contradiction |
4,497 | 35 | A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles. The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days. She is sexually active with her husband and... | I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of ... | Inclusion Criteria:
Patients who are presenting for gynecologic visits or well-woman examinations who still
have an intact uterus and are between the ages of 18 and 51 years, have abnormal uterine
bleeding, and can read and write in English.
Exclusion Criteria:
- Women who ... | HMB- Data Collection Methods | NCT02001324 | Contradiction |
5,980 | 44 | A 48-year-old man comes to the office complaining of heartburn and acid reflux. He has taken over-the-counter antacids but sees no relief. Other medical history is unremarkable. The patient does not use tobacco, alcohol, or illicit drugs. Vital signs are within normal limits. BMI is 31 kg/m2. Physical examination... | I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old gu... | Inclusion Criteria:
1. Gender:Male or female.
2. Age: from 20 y/o to 75 y/o.
3. The diagnosis is Gastroesophageal Reflux Disease.
4. With the symptoms of heartburn or acid regurgitation.
5. After explaining thoroughly the whole research purpose or process, the clie... | Randomized, Double Blind, Placebo Control Trial to Evaluate the Efficacy of Wu-Chu-Yu Tang on Gastroesophageal Reflux Disease (GERD) | NCT01822106 | Entailment |
6,183 | 46 | The patient is a 38-year-old man with cough and body ache that started 3 days ago. He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within n... | I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my tem... | Phase 2a:
Inclusion Criteria:
1. Willing and able to provide written informed consent prior to performing study
procedures
2. Male or female ≥ 18 years and ≤ 85 years
3. Hospitalized for COVID-19
4. Positive SARS-CoV-2 RT-PCR in any body specimen (nasoph... | Study to Evaluate the Safety and Efficacy of XAV-19 in Patients With COVID-19 Induced Moderate Pneumonia | NCT04453384 | Contradiction |
2,661 | 20 | A 49-year-old man comes to the office because of the bulging in his groin. Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases. His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications... | I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to... | Inclusion Criteria:
- Elective surgery
- Males and females
- Adults over 18
- All primitive inguinal hernia
Exclusion Criteria:
- Emergency surgery
- Impossibility to complete the follow-up
- Patients with acquired immunodefici... | Study on Ultrapro vs Polypropylene: Early Results From a Multicentric Experience in Surgery for Hernia | NCT02666040 | Entailment |
676 | 3 | A 51-year-old man comes to the office complaining of fatigue and some sexual problems including lack of libido. The patient doesn't smoke or use any illicit drug. Blood pressure is 120/80 mm Hg and pulse is 70/min. Oxygen saturation is 99% on room air. BMI is 24 kg/m2. Skin examination shows increased pigmentation.... | I am 51 years old and I just came back from the doctor's office. I'm sick and tired of being that exhausted, reaching the point where me and my lovely wife are not touching each other anymore! I'm not smoking or doing drugs! My blood pressure was 120/80 mm Hg, and pulse was 70/min and my oxygen saturation 99%. My BMI i... | Inclusion Criteria:
- patients for study are > 50 years of age,
- on chronic hemodialysis for at least one year,
- with serum ferritin levels > 2000 ng/ml and TSAT > 30%.
Exclusion Criteria:
- malignancies,
- any active infection requiring systemic an... | Assessment of Iron Deposition in Major Organs of Hemodialysis Patients | NCT01169961 | Contradiction |
2,301 | 15 | An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity m... | I brought my 8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weak... | Inclusion Criteria:
- age over 10 years
- neuromuscular disease documented by genetic testing or by muscle biopsy
- not able to walk 10 meters without support
- capable of sitting upright in a wheelchair for at least 3 hours
- subject affiliated to a social se... | Continuous Measurement of the Activity for Clinical Evaluation at Home, for Non-ambulant Neuromuscular Patients | NCT01611597 | Contradiction |
1,997 | 11 | A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that show... | I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and m... | Inclusion Criteria:
1. Lower age limit of research subjects 18 years old and upper age limit of 75 years old.
2. Histologically proven primary gastric adenocarcinoma (Diagnostic biopsies must be
collected within 12 months prior to enrollment).
3. Written informed consent fr... | Comparation of Endoscopic Biopsy and Postoperative Specimen for the Molecular Diagnosis of Gastric Cancer | NCT04809025 | Entailment |
4,986 | 38 | A 60-year-old man comes to the clinic complaining of hand tremor that started few months ago. It is most bothering when he wants to drink from a glass or pour from a bottle. He does not smoke, but drinks occasionally. He recently started consuming more alcohol as his tremor subsides somewhat when he drinks small amoun... | I'm only a 60 years old man but I already suffer from shaky hands. It started a few months ago, and it really bothers me when I want to pour myself a glass or even while drinking. I don't smoke, but I drink alcohol from time to time. To be honest, I've been drinking a little more lately since it helps me with the shaki... | Inclusion Criteria:
- Diagnosed with ET by a Movement Disorder Neurologist.
- Tremors that improve with alcohol.
- Ability to abstain from drinking alcohol or caffeine for at least 2 days before both
the screening and fMRI visits
- Over the age of 21.
... | Functional Imaging of Tremor Circuits and Mechanisms of Treatment Response | NCT02495883 | Entailment |
3,607 | 28 | A 23-year-old woman comes to the emergency department with a history of nosebleeds lasting for 1 hour. She has a history of heavy menses as well as occasional gum bleeding following dental procedures. Her mother also has a history of menorrhagia. Laboratory tests reveal increased bleeding time and slightly increased pa... | I had to rush to the ER because of a non-stop nosebleed that had been on for 1 hour. As a 23-year-old, I always had heavy periods, and sometimes, my gums would bleed after going to the dentist or brushing my teeth. I thought that it was not very alarming since my mom also had heavy periods. I did some lab tests that sh... | Inclusion Criteria:
Routine control patients receiving and not receiving oral anticoagulant therapy
Exclusion Criteria:
Hemolytic and/or lipemic samples were excluded.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
| Differences in Coagulation Test Kits | NCT01109667 | Entailment |
4,385 | 33 | A 20-year-old man comes to the clinic for his routine checkup. The patient wears glasses for myopia and takes no medications. Vital signs are normal. On physical examination, the patient is tall with long upper extremities and fingers. The face appears narrow with down-slanted palpebral fissures, flattened malar bon... | I'm a 20-year-old guy, working as a driver and I went to the clinic for my routine checkup. I have myopia, so I wear glasses and I don't take any other medications. My vitals were normal. I also did a physical exam, and I was told that I have long legs, arms, and fingers. They also told me that my face is quite narrow,... | Inclusion Criteria:
1. Subjects must conform to the diagnostic criteria for MFS;
2. Subjects must be between 12 and 25 years;
3. Subjects must have technically suitable echocardiographic windows to obtain the images
needed to calculate the biophysical properties listed as o... | Losartan Versus Atenolol for the Treatment of Marfan Syndrome | NCT00593710 | Entailment |
3,772 | 30 | A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 chi... | I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 year... | Inclusion Criteria:
- Diagnosis of primary inflammatory knee osteoarthritis of the target joint defined by a
knee osteoarthritis according to the American College of Rheumatology (ACR)
classification and a score ≥ 2 according to the classification of Kellgren and
Lawre... | Safety and Efficacy of a Lipiodol Emulsion for the Embolization of Hypervascularizations in Patients With Knee Pain (LipioJoint1) | NCT04733092 | Entailment |
4,266 | 32 | A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia. The patient is sexually active with his wife and does not use any contraception methods. They have been trying to conceive for the past year with no success. The patient has a past medical history of recurrent p... | I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet ... | Inclusion Criteria:
- Male patient presenting infertility status
Exclusion Criteria:
- none
Male
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
| Sperm Parameters and Sexual Quality of Life | NCT03971786 | Entailment |
1,479 | 9 | A 67-year-old woman comes to the clinic due to recent episode of choking, dysphagia, and cough. Her other medical problems include hypertension, dyslipidemia, and osteoarthritis. She does not smoke or use alcohol. She lives with her husband and she is able to do her own daily activities. She used to teach elementary ... | I'm a 67-year-old lady, and I went to the clinic due to nonstop choking, difficulty swallowing, and coughing. I also suffer from hypertension, cholesterol, and osteoarthritis. I do not smoke or drink alcohol. I live with my husband, and we are independent retired elementary school teachers. During the exam, my blood pr... | Inclusion Criteria:
- Patient has been diagnosed with mild to moderate hypertension (SDBP 95-115 mm Hg)
- Patient has no medical problems or treatments that might effect their blood pressure
Exclusion Criteria:
- Pregnant or lactating females
- Patient has second... | A Study to Investigate the Antihypertensive Efficacy of MK0954 | NCT00887250 | Entailment |
1,092 | 5 | A 23-year-old man comes to the emergency department following an episode of syncope. He was working out when he felt dizzy and passed out without head injury. He has had 3 other episodes of light-headedness over the last year, all happening during physical activity. He never had this experience while resting. He has ... | I'm 23, and I got admitted to the ER because I fainted all of a sudden. I was in the gym, working out, when all of a sudden, I just got dizzy and passed out. Hopefully, I didn't hit my head. It's not my first time having that kind of dizziness at the gym, never when I'm chilling at home tho. I don't have any special me... | Inclusion Criteria:
- above 35 weeks pregnancy
- diabetic mothers
- single intrauterine pregnancy
Exclusion Criteria:
- any other medical disorder
Female
No healthy subjects accepted to join the trial.
Subject must be at least 20 Years old.
Subject must be at mos... | Interventricular Cardiac Septal Thickness in Fetus of Diabetic Mother Correlated to Postnatal Outcome | NCT02136602 | Contradiction |
4,927 | 38 | A 60-year-old man comes to the clinic complaining of hand tremor that started few months ago. It is most bothering when he wants to drink from a glass or pour from a bottle. He does not smoke, but drinks occasionally. He recently started consuming more alcohol as his tremor subsides somewhat when he drinks small amoun... | I'm only a 60 years old man but I already suffer from shaky hands. It started a few months ago, and it really bothers me when I want to pour myself a glass or even while drinking. I don't smoke, but I drink alcohol from time to time. To be honest, I've been drinking a little more lately since it helps me with the shaki... | Inclusion Criteria:
1. Subjects who:
1. previously underwent Exablate thalamotomy for their essential tremor in a
clinical study or in a commercial procedure at least 9 months prior to enrolling
in this study for contralateral Exablate thalamotomy
... | Staged Bilateral Exablate Treatment of Medication Refractory Essential Tremor | NCT03465761 | Entailment |
477 | 2 | A 32-year-old woman comes to the hospital with vaginal spotting. Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with ... | I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing... | Inclusion Criteria:
- singleton intrauterine pregnancy.
- gestational age less than 10 weeks
- history of previous cesarean section(one or more)
Exclusion Criteria:
- negative fetal pole pulsation.
- any condition distorting uterine cavity i.e uterine... | Relation of Implantation Site to Placental Site in Presence or Absence of Cesarean Section Scar | NCT03208842 | Contradiction |
2,412 | 15 | An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity m... | I brought my 8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weak... | Ambulant children age 5-10 years with an established diagnosis of Duchenne Muscular
Dystrophy
Male
No healthy subjects accepted to join the trial.
Subject must be at least 5 Years old.
Subject must be at most 10 Years | A Multicenter Randomized Placebo-Controlled Double-Blind Study to Assess Efficacy and Safety of Glutamine and Creatine Monohydrate in Duchenne Muscular Dystrophy (DMD) | NCT00018109 | Entailment |
1,636 | 10 | A 19-year-old girl comes to the clinic due to a left wrist mass. She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns. Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient n... | I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penli... | Inclusion Criteria:
1. Parental Informed Consent for enrollment in the CHAMPS! CAMP and accompanying research
sessions,
2. Personal assent for participation in the workshop and research sessions.
3. Age 14 to 19 years old ;
4. Affiliation with youth serving organ... | Louisville Teen Pregnancy Prevention Project | NCT01411878 | Entailment |
4,532 | 35 | A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles. The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days. She is sexually active with her husband and... | I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of ... | Inclusion Criteria:
- Healthy women, aged 18-<40 years who wish to use a combined hormonal contraceptive.
- Women not intending to become pregnant for 13 months.
- Intact uterus and both ovaries.
- Prior history of regular menstrual cycles of 28 ± 7 days when not using ho... | Study of the Safety, Efficacy and Cycle Control of a Contraceptive Vaginal Ring | NCT00455156 | Contradiction |
2,944 | 21 | A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year. Over the last few months, he has also noticed weakness in the right upper extremity. BP is 120/75, PR is 80 and temperature is 37 C. Reflex... | I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rat... | PATIENTS:
Inclusion Criteria:
1. ALS diagnosis (possible, probable, or definite) in the past year
2. Expresses distress (4+) on Distress Thermometer, or symptoms of anxiety or depression
(VAS scales)
3. Speaks English
4. Able and willing to give informed... | Coping Effectiveness Training for ALS | NCT01583205 | Entailment |
216 | 1 | A 19-year-old male came to clinic with some sexual concern. He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates. On physical examination, there is some pubic hair and poo... | I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me sm... | Inclusion Criteria:
- Voluntarily sign and date the study consent form(s), which have been approved by an
Institutional Review Board (IRB). Written consent must be obtained prior to the
initiation of any study procedures.
- Male between 18 and 75 years of age.
... | Testopel ® vs. Generic Testosterone Pellets. | NCT04523480 | Entailment |
4,762 | 36 | A 47-year-old woman comes to the clinic complaining of dizziness. She also has occasional nausea and ringing in her right ear. The patient also has difficulty hearing while holding her phone to the left ear, although hearing in her right ear is normal. The dizziness improves spontaneously, and she feels fine between... | The other day, I had to go to the clinic due to severe dizziness. I'm 47 years old, and I've been suffering from nausea and ringing in my right ear. I also have difficulty hearing in my left ear while I hold my phone, even if my hearing in my right ear is normal. The dizziness just gets me all of a sudden but I don't h... | Inclusion Criteria per protocol and informed consent:
- Diagnosis of tinnitus established through a history and physical exam or review of
records.
- Subjects 19-89 years of age
- Tinnitus present for at least 6 months and severe enough to seek medical attention
... | Effect of rTMS on Resting State Brain Activity in Tinnitus | NCT00926237 | Entailment |
6,364 | 46 | The patient is a 38-year-old man with cough and body ache that started 3 days ago. He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within n... | I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my tem... | Inclusion Criteria:
- • Male or female over 18 years of age at the time of enrollment
- Current symptoms of COVID-19 ; fever alone or fever and at least one of the
following symptoms need to be present
- Dry cough
- Sore throat
... | Comparison of the Efficacy of Rapid Tests to Identify COVID-19 Infection (CATCh COVID-19) | NCT04372004 | Entailment |
1,259 | 6 | A 61-year-old man comes to the clinic due to nonproductive cough and progressive dyspnea. The patient's medical conditions include hypertension, hypercholesteremia and peptic ulcer disease. He smokes 2 packs of cigarettes daily for the past 30 years. On examination, there are decreased breath sounds and percussive d... | I am 61 and I had to go to the clinic because I couldn't stop coughing and I experienced some breath shortness. I suffer from hypertension and cholesterol and I also have a stomach ulcer. I should admit that I've been smoking 2 packs of cigarettes every day for the past 30 years. My doctor told me that my breath in my ... | Inclusion Criteria:
TRAINING SET INCLUSION CRITERIA
- Subjects able to understand and sign Informed Consent;
- Males or females >18 years of age;
- Have a pleural effusion of known or unknown origin;
- Scheduled for a diagnostic and/or therapeutic procedure to re... | Multiple Biomarkers in Undiagnosed Pleural Effusion | NCT00316134 | Entailment |
2,629 | 20 | A 49-year-old man comes to the office because of the bulging in his groin. Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases. His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications... | I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to... | Inclusion Criteria:
- inguinal hernia
Exclusion Criteria:
- emergency surgery for incarcerated hernia
- femoral hernia
- recurrent inguinal hernia after laparoscopic inguinal hernia repair
No condition on gender to be admitted to the trial.
No healthy subjects ac... | Prone-position CT for Diagnosing Inguinal Hernia | NCT02939443 | Entailment |
5,273 | 39 | A 55-year-old white woman comes for a routine checkup. She has no significant medical history and does not use tobacco, alcohol, or illicit drugs. The patient's only medication is an over-the-counter multivitamin. Family history is notable for a hip fracture in her mother. Blood pressure is 130/80 mm Hg and pulse i... | I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse w... | Inclusion Criteria:
- older than 18 years old
- having an osteoporosis treatment
- following a Therapeutical Education for Patient
Exclusion Criteria:
- opposition for anonymised data gathering
No condition on gender to be admitted to the trial.
No healthy subjec... | Physician-Pharmacist Collaboration for Osteoporotic Patient Follow-up | NCT02892188 | Entailment |
3,350 | 25 | A 50-year-old woman comes to the clinic with intermittent ear discharge and sense of hearing loss on her left ear. Past medical history is significant for obesity, hyperlipidemia, and diabetes mellitus. Her medications include Metformin, Atorvastatin and Vit D supplement. Vital signs are normal. BMI is 37. Otoscopy s... | I went to the clinic the other day because I had some fluid in my ear and I felt like I could not hear as well as I used to in my left ear. I'm a 50-year-old woman, and I have been obese for a while now. I have diabetes and cholesterol. I take some medication. I take metformin, atorvastatin, and vitamin D supplements. ... | Inclusion Criteria:
1. Subject states that he/she has type 2 diabetes (as evidenced by use of oral
hypoglycemic medication for at least two months).
2. Subject is between 18 and 75 years of age, inclusive.
3. Subject is a male or a non-pregnant, non-lactating female, at lea... | Comparison of Nutritional Products for People With Type 2 Diabetes | NCT00797069 | Contradiction |
188 | 1 | A 19-year-old male came to clinic with some sexual concern. He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates. On physical examination, there is some pubic hair and poo... | I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me sm... | Inclusion Criteria:
- All boys identified in the period from January 1990 to February 2013
Exclusion Criteria:
- Misclassified (other diagnoses)
- Insufficient data
- Lost to follow up
Male
No healthy subjects accepted to join the trial.
Subject must be at least ... | Delayed Puberty in Boys; Clinical and Biochemical Characteristics and Effect of Testosterone Treatment | NCT02034487 | Entailment |
181 | 1 | A 19-year-old male came to clinic with some sexual concern. He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates. On physical examination, there is some pubic hair and poo... | I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me sm... | Inclusion Criteria: Serum testosterone concentration < 300ng/dL Absence of a pituitary or
hypothalamic mass lesions, Presence of gonadotropin response to GnRH, -
Exclusion Criteria: Previous androgen treatment, diabetes mellitus, arterial hypertension
other hormone deficiencies
-
Male
... | The Effects of Gonadotropin Replacement Therapy in Patients With Hypogonadism | NCT02042638 | Entailment |
5,666 | 42 | A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively. On physical examination, the patient's height is in the 5th percentile of her age. Other findings include low-set ears, a high arched palate... | I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a we... | Inclusion Criteria:
- Bone age of at least 15 years for girls or at least 16 years for boys within 6 months
of obtaining the DXA scan
- Previous enrollment in the NCGS core study, 85-036
- Tanner Stage 4 or greater
- Either spontaneous or induced puberty
... | Bone Mineral Density (BMD) in Adolescents With Growth Hormone Deficiency (GHD) | NCT00097526 | Contradiction |
4,639 | 35 | A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles. The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days. She is sexually active with her husband and... | I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of ... | Inclusion Criteria:
1. Age 21 through 45 years (inclusive) at Screening
2. Able and willing to provide written informed consent
3. Able and willing to comply with all study procedure requirements, including, clinical
and laboratory assessments, vaginal and rectal examinatio... | Tenofovir Levels Following Local Application of Tenofovir Reduced-Glycerin 1% Gel | NCT01768962 | Entailment |
3,334 | 25 | A 50-year-old woman comes to the clinic with intermittent ear discharge and sense of hearing loss on her left ear. Past medical history is significant for obesity, hyperlipidemia, and diabetes mellitus. Her medications include Metformin, Atorvastatin and Vit D supplement. Vital signs are normal. BMI is 37. Otoscopy s... | I went to the clinic the other day because I had some fluid in my ear and I felt like I could not hear as well as I used to in my left ear. I'm a 50-year-old woman, and I have been obese for a while now. I have diabetes and cholesterol. I take some medication. I take metformin, atorvastatin, and vitamin D supplements. ... | Inclusion Criteria:
- 18 years of age or older
- Undergo any type of surgeries under general anesthesia in UCI Medical Center
- Mechanically ventilated during surgery
- Arterial line placement is preferred but not required
- Agree to sign the consent and HIPAA... | Comparing Pleth Variability Index (PVI) Measurements at Different Sensing Locations | NCT02124551 | Contradiction |
6,038 | 44 | A 48-year-old man comes to the office complaining of heartburn and acid reflux. He has taken over-the-counter antacids but sees no relief. Other medical history is unremarkable. The patient does not use tobacco, alcohol, or illicit drugs. Vital signs are within normal limits. BMI is 31 kg/m2. Physical examination... | I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old gu... | Inclusion Criteria:
- Patient is an ambulatory, community-dwelling male or nonpregnant female and is at
least 18 years old at the Screening Visit. Lactating females must agree not to
breastfeed.
- Patient has a diagnosis of GERD and reports experiencing GERD symptoms (h... | A Trial of IW-3718 for 8 Weeks in Patients With Symptomatic Gastroesophageal Reflux Disease (GERD) | NCT02637557 | Entailment |
3,785 | 30 | A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 chi... | I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 year... | Inclusion Criteria:
- Knee pain attributed to osteoarthritis for at least 1 year.
- Meet American College of Rheumatology clinical or clinical plus x-ray criteria for
knee osteoarthritis
- Have at least a moderate pain rating on at least one of the five Western
... | Tidal Lavage in Knee Osteoarthritis | NCT00000424 | Entailment |
1,367 | 8 | A 7-month-old boy is brought to emergency by his parents due to irritability and inability to defecate for the past 3 days. The patient has had constipation and discomfort with bowel movements since birth. His symptoms worsened after eating semi-solid foods. Vital signs are normal. Abdominal examination shows diste... | My baby boy just turned 7 months old but my wife and I cannot get a hold of him! He has not been able to poop for 3 days! My poor little thing has been having constipation and bowel problems since birth. But since he ate some semi-solid food it has just been worse! The doctor said his vitals are normal but his belly is... | Inclusion Criteria:
- out-patients children with diagnosis of functional constipation or have faecal
impaction on medical history and physical examination
Exclusion Criteria:
- children with organic causes for defecation disorders, such as Hirschsprung disease,
... | Efficacy and Tolerability of PEG-only Laxative for Fecal Impaction and Chronic Constipation in Children | NCT01592734 | Contradiction |
5,436 | 40 | A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction. Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration. The patient has heavy menstrual cycles each month. She has no other medical problems and takes no medications... | I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical c... | Inclusion Criteria:
- Referred to study by gynecologist or internist/family practitioner with diagnosis of
menorrhagia or referred by self through community advertising or networking
- Prospective pictorial chart scores of menses >100
- Negative pelvic exam and Pap smear... | Treatment and Management of Women With Bleeding Disorders | NCT00111215 | Entailment |
1,349 | 7 | A 3-year-old girl is brought to the clinic by her parents for assessment of her short stature. Physical examination reveals short limbs and a relatively large head. She has a flat nasal bridge and a small midface. The girl's father exhibits similar physical features; however, her mother looks normal. The genetic testin... | I just brought my little 3-year-old girl to the clinic to have her checked up by the doctor. I was worried sick because she was smaller than her classmates. The lovely doctor performed a physical exam and she told me that she has short limbs and a larger head. My girl also has a flat nasal bridge and a small midface. M... | Inclusion Criteria:
1. Written informed consent is obtained from the children's parent(s) / legal guardian(s)
before any study-related activity is carried out
2. The child is able to provide written informed assent, where this is required according
to national legislation... | Observational Study Investigating Clinical & Anthropometric Characteristics of Children With Achondroplasia. | NCT03794609 | Entailment |
4,008 | 30 | A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 chi... | I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 year... | Inclusion Criteria:
- Subject has been diagnosed, according to American College of Rheumatology guidelines,
with osteoarthritis of the hip or knee and requires non-steroidal anti-inflammatory
drugs (NSAIDs) to control their osteoarthritis pain and have access to a touch-tone
... | Study Of "Continuous Use" Of Celecoxib Vs. "Usual or Intermittent Use" | NCT00139776 | Entailment |
341 | 2 | A 32-year-old woman comes to the hospital with vaginal spotting. Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with ... | I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing... | Inclusion Criteria:
1. Be in good general overall health with no chronic medical conditions that result in
periodic exacerbations that require significant medical care.
2. Between 18 and 40 years inclusive at the enrollment visit.
3. Weight ≥ 80 kg.
4. Have regul... | Study Comparing Emergency Contraception Effectiveness in Women Who Weight ≥ 80 kg | NCT03537768 | Contradiction |
2,393 | 15 | An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity m... | I brought my 8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weak... | Inclusion Criteria:
- Beyond 2 years old
- Diagnosis with Duchenne Muscular Dystrophy, and female carriers, genotypically
confirmed
- Diagnosis should be supported by muscle biopsy, if no genetic confirmation.
Exclusion Criteria:
- Presence of other ... | A Registered Cohort Study on Duchenne Muscular Dystrophy | NCT04012671 | Entailment |
2,361 | 15 | An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity m... | I brought my 8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weak... | Inclusion Criteria:
- Patient hospitalized in one of the ICU departments or Continuing Medical or Surgical
Care Units of the Rennes University Hospital for less than 3 months, and presenting
muscle weakness of the lower limbs with a MRC motor test on the main muscle segments
... | VERARE_2 Efficacy of the Observation of Virtual Motor Actions for the Improvement of Gait in Patients With ICU-weakness | NCT04713345 | Entailment |
4,012 | 30 | A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 chi... | I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 year... | Inclusion Criteria:
1. Males or females 18 years of age or older
2. Diagnosis of OA of the knee by a combination of clinical and radiographic findings
3. OA of the knee with Kellgren and Lawrence radiographic classification (Grade 2-4
inclusive) confirmed by posterior-anter... | Efficacy of Amniotic Suspension Allograft in Patients With Osteoarthritis of the Knee | NCT04636229 | Entailment |
2,185 | 14 | A 39-year-old man comes to the emergency department with an acute onset of severe left toe pain. The toe is red and exhibits swelling. The patient is not febrile, and does not remember any recent trauma. Medical history is not significant except for the similar attacks and the diagnosis of gouty arthritis. His medicat... | I'm a 39-year-old man and got admitted to the ER after an unbearable pain in my left toe. My toe was red and terribly swollen. I was still standing on my feet, not febrile and I don't remember hitting my head or anything. I don't have any special medical history, but I had been diagnosed with gout before. I take Lopuri... | Inclusion Criteria:
1. Male, aged 18 ~45 years old;
2. In accordance with the gout classification criteria of the American Rheumatic Society
in 1977 or ACR/EULAR (European Alliance against Rheumatism) in 2015 ;
3. Willing to receive uric acid-lowering drugs regularly for at... | The Influence of Urate-lowering Therapy on Sperm Quality of Male Gouty Patients：A Prospective Cohort Study | NCT04213534 | Contradiction |
4,727 | 35 | A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles. The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days. She is sexually active with her husband and... | I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of ... | Inclusion Criteria:
1. Age group (35-70 years old).
2. Women consenting to have a total laparoscopic hysterectomy.
Exclusion Criteria:
1. Patients with relative contraindication to general anesthesia (e.g. chronic liver cell
failure)(All laparoscopic procedures are... | Uterine Artery Ligation at Origin in Total Laparscopic Hystrectomy | NCT04808583 | Entailment |
5,480 | 41 | A 61-year-old man comes to the emergency department complaining of an acute vision disturbance. He had an episode of vision disturbance in the right eye that occurred suddenly and resolved spontaneously in 15 minutes. He also has right jaw pain while chewing. He also complains of fatigue and hip muscle aches over the ... | I’m a 61-year-old man and I came to the ER because I had a sudden episode where I couldn’t see out of my right eye. It only lasted about 15 minutes and went away on its own but it really scared me. I’ve also been having pain in my right jaw when I chew. For the past few months I’ve felt really tired and noticed my hips... | Inclusion Criteria:
- Confirmed diagnosis of GCA and having a diagnosis of LV-GCA confirmed by imaging
(PET/CT)
- Informed consent to the local GCA cohort BARK
- Followed for GCA treatment in the outpatient department.
Exclusion Criteria:
- Known hyp... | Longitudinal Imaging in Patients With Large Vessel Vasculitis to Predict Further Disease Course | NCT04204876 | Contradiction |
1,102 | 5 | A 23-year-old man comes to the emergency department following an episode of syncope. He was working out when he felt dizzy and passed out without head injury. He has had 3 other episodes of light-headedness over the last year, all happening during physical activity. He never had this experience while resting. He has ... | I'm 23, and I got admitted to the ER because I fainted all of a sudden. I was in the gym, working out, when all of a sudden, I just got dizzy and passed out. Hopefully, I didn't hit my head. It's not my first time having that kind of dizziness at the gym, never when I'm chilling at home tho. I don't have any special me... | INCLUSION CRITERIA:
Patients of either gender, aged 18-85 years.
Symptomatic patients receiving clinically indicated evaluation for cardiomyopathy and found
to have obstructive HCM.
LV outflow tract gradient greater than 30 mm Hg at rest by echocardiography or cardiac
catheter... | Alcohol Septal Ablation in Obstructive Hypertrophic Cardiomyopathy: A Pilot Study | NCT00035386 | Entailment |
5,938 | 44 | A 48-year-old man comes to the office complaining of heartburn and acid reflux. He has taken over-the-counter antacids but sees no relief. Other medical history is unremarkable. The patient does not use tobacco, alcohol, or illicit drugs. Vital signs are within normal limits. BMI is 31 kg/m2. Physical examination... | I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old gu... | Inclusion Criteria:
- Adults, 18-59 years old
- moderate heartburn at least 3 days/week
- males and non-pregnant/non-lactating females
- Complete relief while using a PPI or only some relief of symptoms while on a PPI
Exclusion Criteria:
- erosive eso... | Do Acid Sensing Ion Channels Contribute to Heartburn? | NCT01095133 | Contradiction |
4,946 | 38 | A 60-year-old man comes to the clinic complaining of hand tremor that started few months ago. It is most bothering when he wants to drink from a glass or pour from a bottle. He does not smoke, but drinks occasionally. He recently started consuming more alcohol as his tremor subsides somewhat when he drinks small amoun... | I'm only a 60 years old man but I already suffer from shaky hands. It started a few months ago, and it really bothers me when I want to pour myself a glass or even while drinking. I don't smoke, but I drink alcohol from time to time. To be honest, I've been drinking a little more lately since it helps me with the shaki... | Inclusion Criteria:
- Must be ≥22 years of age
- Competent and willing to provide written, informed consent to participate in the study
- A diagnosis of essential tremor as confirmed from clinical history and examination by
a movement disorder neurologist
- A... | Prospective Study for Symptomatic Relief of ET With Cala Therapy | NCT03597100 | Entailment |
2,435 | 16 | A 39-year-old woman comes to the clinic complaining of arthralgias and nodules on her legs. She has no fever or other skin rashes. The prior medical condition is unremarkable, and she takes no medications. On physical examination, there is moderate hepatomegaly. The lesions on her legs are tender and present predomin... | I'm just a 39-year-old young woman but lately I have noticed some underlying cysts on my legs and my joints were hurting so much. I don't have a fever. I don't have rashes. My medical history is totally clean and I don't take any medication. When I went to the clinic they did a physical examination where they found tha... | Inclusion Criteria:
- Patients with suspected pulmonary sarcoidosis stage I/ II
- Age > 18 years
- Both males and females
- Written informed consent is obtained.
Exclusion Criteria:
- Patients with obvious other organ involvement of sarcoidosis where ... | Trial for the Diagnosis of Sarcoidosis | NCT00872612 | Contradiction |
3,643 | 28 | A 23-year-old woman comes to the emergency department with a history of nosebleeds lasting for 1 hour. She has a history of heavy menses as well as occasional gum bleeding following dental procedures. Her mother also has a history of menorrhagia. Laboratory tests reveal increased bleeding time and slightly increased pa... | I had to rush to the ER because of a non-stop nosebleed that had been on for 1 hour. As a 23-year-old, I always had heavy periods, and sometimes, my gums would bleed after going to the dentist or brushing my teeth. I thought that it was not very alarming since my mom also had heavy periods. I did some lab tests that sh... | Inclusion Criteria:
- all adult patients visiting the emergency department or urgent care clinic at any one
of the six participating sites during the allocated one month time period
Exclusion Criteria:
- those who do not meet inclusion criteria
No condition on gender to be ... | ED Overcrowding Validation Study | NCT02754245 | Entailment |
5,263 | 39 | A 55-year-old white woman comes for a routine checkup. She has no significant medical history and does not use tobacco, alcohol, or illicit drugs. The patient's only medication is an over-the-counter multivitamin. Family history is notable for a hip fracture in her mother. Blood pressure is 130/80 mm Hg and pulse i... | I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse w... | Inclusion Criteria:
- Informed consent obtained before any trial-related activities
- Postmenopausal women and male aged 50 years or old
- Osteoporosis by DXA or fragility fracture history
- Osteopenia with more than one osteoporotic risk factors
Exclusion Criter... | Intervention Study of Drugs in Patients Osteopenia and Osteoporosis | NCT04719572 | Entailment |
3,874 | 30 | A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 chi... | I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 year... | Inclusion Criteria:
- Painful, or predominantly unilateral painful, knee osteoarthritis of any etiology
- Knee without clinical signs of intra-articular effusion
- Kellgren score ≥ II on X-ray
- WOMAC pain sub-score ≥ 5 in the month preceding the inclusion visit
... | Trial Comparing Botulin Toxin Versus Hyaluronic Acid by Intra-articular Injection for the Treatment of Painful Knee Osteoarthritis | NCT02832713 | Entailment |
5,761 | 43 | A 27-year-old woman comes to the dermatology clinic with skin rash and oral ulcers. The rashes are mildly itchy. The patient has no other medical conditions and takes no medications. Vital signs are normal. On examination, there are pink papules symmetrically distributed over the anterior surfaces of the shins and a... | I went to the dermatologist because I had rashes on my skin and ulcers in my mouth. The rashes were not that itchy. I don't get it! I'm 27, I don't take medication, nor I don't have any other illnesses. My vitals were normal. My doc told me there were pink spots on the back of my throat. I'm heterosexual and have been ... | Inclusion Criteria:
1. Biopsy-proven diagnosis of OLP as per WHO histological criteria* with no evidence of
epithelial dysplasia or malignancy.
2. Presence of painful oral symptoms associated to OLP, with minimum severity of pain
being 3 or more, on a 0-10 numeric pain ra... | The Clinical and Biological Effects Of The Use Of Probiotic VSL#3 In Patients With Oral Lichen Planus | NCT03052179 | Contradiction |
2,231 | 14 | A 39-year-old man comes to the emergency department with an acute onset of severe left toe pain. The toe is red and exhibits swelling. The patient is not febrile, and does not remember any recent trauma. Medical history is not significant except for the similar attacks and the diagnosis of gouty arthritis. His medicat... | I'm a 39-year-old man and got admitted to the ER after an unbearable pain in my left toe. My toe was red and terribly swollen. I was still standing on my feet, not febrile and I don't remember hitting my head or anything. I don't have any special medical history, but I had been diagnosed with gout before. I take Lopuri... | Inclusion Criteria:
Patients (> 18 years old) with gout flare defined by following items :
- Identification of sodium urate crystals in synovial fluid analysis
- Or gout flare diagnosis according to Nijmegen criteria (score > 8/13)
- Man (2 pts)
- Histo... | Relation Between Blood Concentration of Colchicine and Response to Colchicine Treatment in Gout Flare | NCT03933007 | Entailment |
1,862 | 11 | A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that show... | I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and m... | Inclusion Criteria:
- Patients with gastric intestinal metaplasia and/or gastric cancer
- Healthy controls
Exclusion Criteria:
- Metabolic syndrome and its components
- IBD
- Autoimmune diseases
- Otherwise tumours
No condition on gender t... | Microbiome Analysis in Gastric Intestinal Metaplasia and in Gastric Cancer and Subtypes Correlation | NCT04365946 | Entailment |
1,354 | 7 | A 3-year-old girl is brought to the clinic by her parents for assessment of her short stature. Physical examination reveals short limbs and a relatively large head. She has a flat nasal bridge and a small midface. The girl's father exhibits similar physical features; however, her mother looks normal. The genetic testin... | I just brought my little 3-year-old girl to the clinic to have her checked up by the doctor. I was worried sick because she was smaller than her classmates. The lovely doctor performed a physical exam and she told me that she has short limbs and a larger head. My girl also has a flat nasal bridge and a small midface. M... | Inclusion Criteria:
- Molecular or clinical diagnosis of achondroplasia (as confirmed by physical exam
and/or radiograph review by the PI, one of the co-PIs or other qualified clinical
geneticists)
- Subjects must have been seen for a clinical genetics visit at Johns Ho... | Achondroplasia Natural History Multicenter Clinical Study | NCT02597881 | Entailment |
612 | 2 | A 32-year-old woman comes to the hospital with vaginal spotting. Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with ... | I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing... | Inclusion Criteria:
- Correctly diagnosed with recurrent miscarriages
Exclusion Criteria:
- Known course of the condition
Female
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 45 Years | Description of the Uterine Cavity in Patients With Recurrent Miscarriages | NCT02746588 | Entailment |
1,378 | 8 | A 7-month-old boy is brought to emergency by his parents due to irritability and inability to defecate for the past 3 days. The patient has had constipation and discomfort with bowel movements since birth. His symptoms worsened after eating semi-solid foods. Vital signs are normal. Abdominal examination shows diste... | My baby boy just turned 7 months old but my wife and I cannot get a hold of him! He has not been able to poop for 3 days! My poor little thing has been having constipation and bowel problems since birth. But since he ate some semi-solid food it has just been worse! The doctor said his vitals are normal but his belly is... | Inclusion Criteria:
- Children with Idiopathic constipation
Exclusion Criteria:
- Hirschsprung's disease or Anorectal malformations
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 2 Years old.
Subject must be a... | Botulinum Toxin Injection Versus Anal Myectomy in Management of Idiopathic Constipation | NCT02361749 | Contradiction |
5,677 | 42 | A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively. On physical examination, the patient's height is in the 5th percentile of her age. Other findings include low-set ears, a high arched palate... | I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a we... | Inclusion Criteria:
The study was conducted in children attending 5th and 6th grade in all 20 public schools of
the Municipality of Puente Alto, Santiago, Chile. All students were invited to participate
in the study. Parents or their representatives signed an informed consent form and
b... | Metabolic Syndrome in Children and Adolescents | NCT03203863 | Contradiction |
5,489 | 41 | A 61-year-old man comes to the emergency department complaining of an acute vision disturbance. He had an episode of vision disturbance in the right eye that occurred suddenly and resolved spontaneously in 15 minutes. He also has right jaw pain while chewing. He also complains of fatigue and hip muscle aches over the ... | I’m a 61-year-old man and I came to the ER because I had a sudden episode where I couldn’t see out of my right eye. It only lasted about 15 minutes and went away on its own but it really scared me. I’ve also been having pain in my right jaw when I chew. For the past few months I’ve felt really tired and noticed my hips... | Inclusion Criteria:
1. Diagnosis of Giant Cell Arteritis (GCA) defined by the following Revised GCA Diagnosis
Criteria:
- Age ≥50 years.
- History of Erythrocyte Sedimentation Rate (ESR) ≥ 50 mm/hour or C-Reactive
Protein (CRP) ≥ 10 mg/L.
... | Baricitinib in Relapsing Giant Cell Arteritis | NCT03026504 | Contradiction |
6,462 | 47 | A 41-year-old woman comes to the dermatology clinic complaining of facial redness, especially on her forehead and cheeks. She noticed that the redness gets worse in the summer and after sun exposure. She is otherwise healthy. On physical examination, she has multiple papules and pustules present on her forehead, cheeks... | I'm 41, married with 2 lovely kids who are 5 and 9 years old. I have an IUD and I don't want to have more kids. I don't smoke or drink alcohol. I had to go to the dermatology clinic because I had terrible redness on my face, especially on my forehead and cheeks. It got worse in the summer and after being under the sun.... | Key Inclusion Criteria:
1. Male or female who is at least 18 years of age or older.
2. A clinical diagnosis of facial rosacea.
3. A Clinician Erythema Assessment (CEA) score of greater than or equal to 3 at Screening
and at Baseline/Day 1 (prior to the study drug applicatio... | Phase 3 Efficacy and Safety Study of CD07805/47 Topical Gel in Subjects With Facial Erythema of Rosacea | NCT01789775 | Entailment |
5,083 | 39 | A 55-year-old white woman comes for a routine checkup. She has no significant medical history and does not use tobacco, alcohol, or illicit drugs. The patient's only medication is an over-the-counter multivitamin. Family history is notable for a hip fracture in her mother. Blood pressure is 130/80 mm Hg and pulse i... | I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse w... | Inclusion Criteria:
- Postmenopausal women 45 years or older. No period for at least two years.
- History of back pain that started at least 2 months prior to the initial visit (likely
due to spinal bone fracture determined by investigator).
- Minimum of one moderate spi... | Effect of Teriparatide Compared to Risedronate on Back Pain in Women With a Spine Fracture Caused by Osteoporosis | NCT00343252 | Contradiction |
3,273 | 23 | A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn. The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness. She also reports occasional joint pain. Medical history... | I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to t... | Inclusion Criteria:
- Suspected or confirmed Sjogren's syndrome
- 18+ years of age
Exclusion Criteria:
- Any condition that in the opinion of the investigator may confound study results or
cause concerns for safety
No condition on gender to be admitted to the tr... | Corneal Nerve Structure in Sjogren's | NCT03203382 | Entailment |
2,376 | 15 | An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity m... | I brought my 8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weak... | Inclusion Criteria:
- Boys aged 8 to 18 years with DMD/BMD confirmed genetically or by muscle biopsy
- Informed consent
Exclusion Criteria:
- Other clinically significant concomitant disease states (e.g., renal failure)
- Inability to follow the procedures of the... | Cardiac Involvement in Patients With Duchenne/Becker Muscular Dystrophy | NCT02470962 | Entailment |
6,590 | 48 | A 20-year-old man comes to the emergency due to bleeding after a tooth extraction. The bleeding has persisted for approximately 30 minutes despite constant direct pressure. He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family histo... | I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove... | Inclusion Criteria:
- Males, age 18 to 65 years
- Subjects with Severe hemophilia A with a documented plasma FVIII level of <1%
- ≥ 150 exposure days with FVIII concentrate(s) as supported by medical records
Exclusion Criteria:
- Evidence of current or ... | Single Dose Study in Subjects With Severe Hemophilia A Comparing Pharmacokinetic Parameters for BAY81-8973 and Advate | NCT02483208 | Contradiction |
4,751 | 36 | A 47-year-old woman comes to the clinic complaining of dizziness. She also has occasional nausea and ringing in her right ear. The patient also has difficulty hearing while holding her phone to the left ear, although hearing in her right ear is normal. The dizziness improves spontaneously, and she feels fine between... | The other day, I had to go to the clinic due to severe dizziness. I'm 47 years old, and I've been suffering from nausea and ringing in my right ear. I also have difficulty hearing in my left ear while I hold my phone, even if my hearing in my right ear is normal. The dizziness just gets me all of a sudden but I don't h... | Inclusion Criteria:
1. Adults aged between 18 to 70 years old;
2. Diagnosed with unilateral ISSNHL according to the National Institute for Deafness and
Communication Disorders (NICDC) criteria30: a decrease in hearing of ≥30 decibels
(dB), affecting at least 3 consecutive... | Vestibular Prognosis Assessment of ISSNHL With Vestibular Dysfunction Treated With Oral or Intratympanic Glucocorticoids | NCT03974867 | Entailment |
3,316 | 24 | A 4-year-old boy comes to the office for the follow up of his confirmed oculocutaneous albinism. The patient was born at 38 weeks gestation with no complications. Vital signs are normal. Weight and height are at the 50th percentile. On examination, iris transillumination is present, and there are no apparent foveae... | I brought my four-year-old son to his follow-up consultation for his albinism. All his hair is white, even lashes and eyebrows. My baby was born at 38 weeks pregnant with no complications whatsoever. During the consultations his vitals were normal and now his weight and height are at the 50th percentile. The doctor did... | Inclusion Criteria:
- Confirmed diagnosis of ONH (Diagnosis will be confirmed by ocular fundus
photography.Disc-macula distance 0.35 or below. In eyes without ONH, the DD/DM ratio
is greater than 0.3581.)
- Ages 2-10 years
- Ability to ambulate independently... | Biological Clock Dysfunction in Optic Nerve Hypoplasia | NCT00825591 | Entailment |
882 | 4 | A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes. The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief. Past medical history is notable for hypertension and hypercholesteremia. ... | I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tyl... | Inclusion Criteria:
Subjects with a clinical definition of knee OA using NICE guidelines:
- Age ≥ 45
- Walking related joint pain in the last week that averages ≥ 4 on 11-point numeric
rating scale, where 0 = no pain and 10 = worst pain possible
- History of kne... | Effectiveness of a Walking Intervention on Impact Loading and Pain | NCT04148807 | Entailment |
5,004 | 38 | A 60-year-old man comes to the clinic complaining of hand tremor that started few months ago. It is most bothering when he wants to drink from a glass or pour from a bottle. He does not smoke, but drinks occasionally. He recently started consuming more alcohol as his tremor subsides somewhat when he drinks small amoun... | I'm only a 60 years old man but I already suffer from shaky hands. It started a few months ago, and it really bothers me when I want to pour myself a glass or even while drinking. I don't smoke, but I drink alcohol from time to time. To be honest, I've been drinking a little more lately since it helps me with the shaki... | Inclusion Criteria:
- Patients in good general health
- Definite ET based on the TRIG diagnostic criteria
- Patients must have tremor affecting both upper extremities and at least 1 upper
extremity must have a postural or action/intention tremor that is rated from 2
... | A Proof of Concept Study of the Effectiveness of Carisbamate in the Treatment of Essential Tremor | NCT00524056 | Entailment |
2,547 | 18 | A 2-year-old boy is brought to the office by his parents due to a rash that started 1 week ago. A similar red, itchy rash on the cheeks, trunk, and arms has occurred intermittently since infancy. The patient has had a few upper respiratory infections but no major illnesses. Vaccinations are up to date, and he takes ... | I just brought my two-year-old son to the doctor's office because he had a rash for like one week. His rash was on the cheeks, the trunk, and his arms. He already had this before, and it keeps coming back from time to time to time. In the past, he had some respiratory infections but he has never been this sick. His vac... | Inclusion Criteria:
- Patient with AD, defined according to the criteria of the United Kingdom Working Party
: AD should be diagnosed when a child has an itchy skin condition plus three or more
of the following: Protocol EDU DA RC15_0035 Version n°4 du 15/09/16 Page 28 sur 44
... | A Multicenter Randomized Control Trial in Children With Moderate to Severe Atopic Dermatitis to Assess the Benefit of a Nurse-led One-to-one Education Program in Addition to Standard Care Compared to Standard Care Alone on the Long Term Control of Disease Severity at 6 Months | NCT02634905 | Entailment |
2,851 | 21 | A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year. Over the last few months, he has also noticed weakness in the right upper extremity. BP is 120/75, PR is 80 and temperature is 37 C. Reflex... | I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rat... | Inclusion Criteria:
- Patients with a diagnosis of probable, laboratory-supported probable, or definite
amyotrophic lateral sclerosis according to the El Escorial revised criteria
- Disease duration ≤ 24 months
- Disease progression in the past 3 months
- Sco... | Rehabilitative Trial With tDCS in Amyotrophic Lateral Sclerosis | NCT03293394 | Entailment |
4,064 | 30 | A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 chi... | I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 year... | Inclusion Criteria:
- Both males and females
- Patients with age 45-65 years
- Patients with knee OA of grade II or III according to Kellgren-Lawrence grade.
- Pain intensity ranging between> 5 measured by Numeric Pain Rating Scale.
- Patients who had minimum ... | Low Level Laser Therapy in Knee Osteoarthritis | NCT04682171 | Entailment |
3,626 | 28 | A 23-year-old woman comes to the emergency department with a history of nosebleeds lasting for 1 hour. She has a history of heavy menses as well as occasional gum bleeding following dental procedures. Her mother also has a history of menorrhagia. Laboratory tests reveal increased bleeding time and slightly increased pa... | I had to rush to the ER because of a non-stop nosebleed that had been on for 1 hour. As a 23-year-old, I always had heavy periods, and sometimes, my gums would bleed after going to the dentist or brushing my teeth. I thought that it was not very alarming since my mom also had heavy periods. I did some lab tests that sh... | Inclusion Criteria:
- All patients that visit the ED during one of the two periods of recruitment, monday to
friday between 8:30am and 4:30pm, will be screened for inclusion. We chose this time
interval as they correspond to period that can be exposed to a cross checking, which
... | Cross Checking to Reduce Adverse Events in the Emergency Department | NCT02356926 | Entailment |
1,209 | 6 | A 61-year-old man comes to the clinic due to nonproductive cough and progressive dyspnea. The patient's medical conditions include hypertension, hypercholesteremia and peptic ulcer disease. He smokes 2 packs of cigarettes daily for the past 30 years. On examination, there are decreased breath sounds and percussive d... | I am 61 and I had to go to the clinic because I couldn't stop coughing and I experienced some breath shortness. I suffer from hypertension and cholesterol and I also have a stomach ulcer. I should admit that I've been smoking 2 packs of cigarettes every day for the past 30 years. My doctor told me that my breath in my ... | Inclusion Criteria:
- Age greater than or equal to 18 years old
- Diagnosis of a paramalignant pleural effusion (defined as a recurrent pleural effusion
directly caused by malignancy with known thoracic involvement)
- Estimated life expectancy greater than 3 months
... | Talc Outpatient Pleurodesis With Indwelling Catheter | NCT03973957 | Entailment |
760 | 4 | A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes. The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief. Past medical history is notable for hypertension and hypercholesteremia. ... | I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tyl... | Inclusion Criteria:
- were 18 years of age or older, reported unilateral ankle pain for at least 6 months
and had either reported no significant benefit from conservative treatment (rest,
physical therapy, orthoses or pain medications etc.) or were unable to tolerate side
... | Efficacy of 3 Weekly Injections of Hyaluronate in Patients With Ankle Osteoarthritis | NCT00918736 | Contradiction |
1,045 | 5 | A 23-year-old man comes to the emergency department following an episode of syncope. He was working out when he felt dizzy and passed out without head injury. He has had 3 other episodes of light-headedness over the last year, all happening during physical activity. He never had this experience while resting. He has ... | I'm 23, and I got admitted to the ER because I fainted all of a sudden. I was in the gym, working out, when all of a sudden, I just got dizzy and passed out. Hopefully, I didn't hit my head. It's not my first time having that kind of dizziness at the gym, never when I'm chilling at home tho. I don't have any special me... | Inclusion Criteria:
- Male or Female over 75 years-old
- Emergency consult resulting on an hospitalization in the geriatric service or in the
internal medicine service
- Hospitalised in the Centre Hospitalier Intercommunal de Toulon for syncope, presenting
t... | Prevalence Rate of Pulmonary Embolism Among Not Anticoagulated Patients | NCT03525535 | Contradiction |
6,358 | 46 | The patient is a 38-year-old man with cough and body ache that started 3 days ago. He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within n... | I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my tem... | Inclusion Criteria:
- Confirmed diagnosis of COVID19 virus infection (buffer/BAL/positive IgG serology)
- Age >18 years
- Able to express informed consent to participate in the study
Exclusion Criteria:
- patients unable to express consent,
- patients... | Registry of Coronavirus Complications - CORRELATION WITH GLYCOMIC PROFILE | NCT04788433 | Entailment |
4,265 | 32 | A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia. The patient is sexually active with his wife and does not use any contraception methods. They have been trying to conceive for the past year with no success. The patient has a past medical history of recurrent p... | I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet ... | Inclusion Criteria:
- Have no clinically relevant abnormalities
- Non smoker
Exclusion Criteria:
- Have or had a history of clinically significant, severe, progressive, or uncontrolled
renal, hepatic, hematological, gastrointestinal, endocrine, pulmonary, cardia... | A Study of the Pharmacokinetics of Ustekinumab in Chinese Male Subjects | NCT01081704 | Entailment |
6,602 | 48 | A 20-year-old man comes to the emergency due to bleeding after a tooth extraction. The bleeding has persisted for approximately 30 minutes despite constant direct pressure. He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family histo... | I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove... | Inclusion Criteria:
- Males with severe congenital hemophilia A or B defined as <1% FVIII or <2% FIX
concentration by measurement at the time of screening or from reliable prior
documentation (e.g., measurement in other clinical Bayer trials, or diagnostic genetic
test... | A Study to Assess Pharmacokinetics and Pharmacodynamics Following Administration of BAY1093884 in Patients With Severe Hemophilia | NCT03481946 | Contradiction |
5,982 | 44 | A 48-year-old man comes to the office complaining of heartburn and acid reflux. He has taken over-the-counter antacids but sees no relief. Other medical history is unremarkable. The patient does not use tobacco, alcohol, or illicit drugs. Vital signs are within normal limits. BMI is 31 kg/m2. Physical examination... | I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old gu... | Inclusion Criteria:
1. Experiencing heartburn at least 2 days per week over the past month.
2. Having heartburn that responds to heartburn medication.
3. Be willing to discontinue the use of heartburn treatment for 7 days prior to inclusion
in the study.
Exclusion ... | Efficacy/Safety of Lansoprazole in Patients With Frequent Heartburn | NCT00389948 | Entailment |
3,069 | 22 | A 15-year-old boy with mild intellectual disability is brought to the office by his parents for a routine physical examination. The boy is going to a school for students with learning disabilities. The patient was adopted, and his immunizations are up to date. Review of the patient's medical records is notable for c... | My husband and I brought our 15-year-old son to the clinic for his routine exam. My son is going to school for special needs students. We adopted him a few years ago. His vaccinations are up to date. He already passed some chromosome testing and they found that he has a fragile X syndrome. The doctor told us that it co... | Inclusion Criteria for Individuals with Intellectual Disabilities:
- Participants will have an age range between 2 and 17.11 years of age inclusive
- Male or female
- Diagnosis of an intellectual disability based on the fourth edition of the Diagnostic
and Statistical Ma... | Pivotal Response Treatment for Individuals With Intellectual Disabilities | NCT01988623 | Entailment |
2,195 | 14 | A 39-year-old man comes to the emergency department with an acute onset of severe left toe pain. The toe is red and exhibits swelling. The patient is not febrile, and does not remember any recent trauma. Medical history is not significant except for the similar attacks and the diagnosis of gouty arthritis. His medicat... | I'm a 39-year-old man and got admitted to the ER after an unbearable pain in my left toe. My toe was red and terribly swollen. I was still standing on my feet, not febrile and I don't remember hitting my head or anything. I don't have any special medical history, but I had been diagnosed with gout before. I take Lopuri... | Inclusion Criteria:
- Subjects must present with confirmed diagnosis of gout, meeting the American College
of Rheumatology (ACR) 1977 preliminary criteria for the classification of acute
arthritis of primary gout
- Subjects must have experienced at least one (1) acute g... | Bucillamine for the Treatment of Acute Gout Flare in Subjects With Moderate to Severe Gout | NCT02330796 | Contradiction |
6,106 | 46 | The patient is a 38-year-old man with cough and body ache that started 3 days ago. He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within n... | I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my tem... | Inclusion Criteria:
- adults with COVID19 (proven by polymerase chain reaction, or with strong clinical
suspicion based on clinical features and/or radiodiagnostics)
Exclusion Criteria:
- minors
No condition on gender to be admitted to the trial.
No healthy subjects accepte... | COVID-19 Resuscitation Plans and Decisions on Escalation and Limitation of Treatment | NCT04743232 | Contradiction |
4,079 | 31 | A 25-year-old woman comes to the clinic with her roommate. The roommate says that the patient has twice fallen asleep while they were talking. The patient has regularly fallen asleep in the afternoon while reading or watching television but typically feels refreshed after a brief nap. She also reveals that she somet... | I brought my roommate to the clinic because she kept falling asleep when we were having a conversation. We're both 25 and usually healthy girls. She usually takes a nap in the afternoon while reading or watching TV, but usually, she is quite energetic afterward. She told me that she sometimes hears a voice before falli... | Inclusion Criteria:
---
Exclusion Criteria:
Participants with a history of neurological disorders or of sleep disorders will be
excluded.
Participants who do not believe they would be able to fall asleep in the lab will be
excluded.
Participants with severe a... | Reactivating Specific Memories During Sleep in Conjunction With a Suppression Context | NCT04702750 | Contradiction |
2,474 | 16 | A 39-year-old woman comes to the clinic complaining of arthralgias and nodules on her legs. She has no fever or other skin rashes. The prior medical condition is unremarkable, and she takes no medications. On physical examination, there is moderate hepatomegaly. The lesions on her legs are tender and present predomin... | I'm just a 39-year-old young woman but lately I have noticed some underlying cysts on my legs and my joints were hurting so much. I don't have a fever. I don't have rashes. My medical history is totally clean and I don't take any medication. When I went to the clinic they did a physical examination where they found tha... | Inclusion Criteria:
- 18 years old or older
- Diagnosis of cutaneous sarcoidosis or granuloma annulare with supportive skin biopsies
in which other causes of granulomas (infectious, foreign body) have been ruled out
- Patients with either: Cutaneous Sarcoidosis Activity ... | Open-label Trial of Tofacitinib in Cutaneous Sarcoidosis and Granuloma Annulare | NCT03910543 | Entailment |
6,324 | 46 | The patient is a 38-year-old man with cough and body ache that started 3 days ago. He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within n... | I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my tem... | Inclusion Criteria:
- Patient with COVID-19 confirmed by positive RT-PCR or considered as probable by the
in-charge physician,
- ≥18 years old,
- Not requiring respiratory assistance and/or other intensive care
- Not subject to a limitation of active therapeu... | Point Of Care UltraSonography for Risk-stratification of COVID-19 Patients | NCT04338100 | Entailment |
3,544 | 26 | A 33-year-old woman comes to clinic complaining of progressive fatigue, decreased appetite, and 11-lb weight loss in the past 2 months. She uses levothyroxine because of the previously diagnosed Hashimoto disease. She has no other medical conditions and does not use tobacco, alcohol, or illicit drugs. Physical examin... | I went to the clinic because I was really suffering from fatigue and decreased appetite and I also lost 11 pounds over the past two months. I'm just 33 years old so that's not normal, especially for a woman. I take levothyroxine because I have been diagnosed with Hashimoto disease. I don't have any other medical condit... | Inclusion Criteria:
- Male or female patients ≥ 18years of age with Primary Adrenal Insufficiency (Addison's
disease) confirmed on biochemical testing.
- Male or female patients ≥ 18years of age with ACTH deficiency defined by a stimulated
peak cortisol in response to i... | Optimising Steroid Replacement in Patients With Adrenal Insufficiency | NCT03282487 | Entailment |
325 | 2 | A 32-year-old woman comes to the hospital with vaginal spotting. Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with ... | I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing... | Inclusion criteria
- age<40 years,
- first ICSI cycle,
- third day FSH< 10 mIU/mL,
- serum E2 level on day of hCG administration <4,000 pg/mL,
- number of ova obtained >15
Exclusion Criteria:
- age 40 years or more,
- basal FSH... | Is Adding E2 to P4 Luteal Support In High Responder Long Gn-RH Agonist ICSI Cycles Detrimental to Outcome? RCT | NCT01790282 | Contradiction |
5,381 | 40 | A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction. Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration. The patient has heavy menstrual cycles each month. She has no other medical problems and takes no medications... | I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical c... | Inclusion Criteria:
- New subjects undergoing evaluation for the diagnosis of VWD determined to have a
VWF:Ag or VWF: RCo < 50 IU/dl and or a VWF:RCo/VWF:Ag of <0.7. Also subjects will be
included if Type 2 N VWD is clinically suspected
Exclusion Criteria:
- Th... | Investigating a Von Willebrand Factor (VWF) Functional Screening Assay for Assigning the Phenotypic Variants of Von Willebrand Disease (VWD) | NCT02466789 | Entailment |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.